U.S. patent number 3,660,033 [Application Number 04/861,728] was granted by the patent office on 1972-05-02 for disposable specimen collection and analysis bag.
Invention is credited to Leroy L. Schwartz.
United States Patent |
3,660,033 |
Schwartz |
May 2, 1972 |
DISPOSABLE SPECIMEN COLLECTION AND ANALYSIS BAG
Abstract
A flexible sealed bag for containing and analyzing a specimen,
comprising: an entrance; a first reservoir, communicating with the
entrance, which receives specimen through the entrance; manually
actuatable sealing means between the entrance and the reservoir;
with a solid specimen, a liquid solvent in the reservoir into which
the specimen becomes mixed; a narrow channel connecting the
reservoir with an analysis chamber for permitting liquid in the
reservoir to pass into the analysis chamber; the channel from
reservoir to analysis chamber including manually actuatable sealing
means for closing off the channel after adequate liquid has passed
from the reservoir into the analysis chamber; the analysis chamber
already holding a substance for reacting with the liquid
transferred thereto; whereby a liquid specimen is divided into two
parts, the part in the reservoir and the part in the analysis
chamber.
Inventors: |
Schwartz; Leroy L.
(Eltingville, Staten Island, NY) |
Family
ID: |
25336595 |
Appl.
No.: |
04/861,728 |
Filed: |
September 29, 1969 |
Current U.S.
Class: |
436/174;
128/DIG.24; 206/219; 422/944; 600/580; 422/417 |
Current CPC
Class: |
B01L
3/505 (20130101); A61F 5/443 (20130101); A61F
5/4404 (20130101); Y10S 128/24 (20130101); Y10T
436/25 (20150115) |
Current International
Class: |
A61F
5/443 (20060101); A61F 5/44 (20060101); B01L
3/00 (20060101); G01m 001/18 (); G01m 021/24 ();
B65d 075/12 () |
Field of
Search: |
;23/230,232,253,254
;128/2,272 ;206/47A,47R ;229/56,62.5 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Wolk; Morris O.
Assistant Examiner: Katz; Elliott A.
Claims
I claim:
1. A self-contained, integral, disposable analysis bag for
permitting at least one analysis procedure to be performed on a
portion of a single specimen while another portion of that specimen
is isolated and stored, comprising,
a specimen entrance into said bag;
a reservoir, large enough to store a significant quantity of the
specimen, communicating with said entrance for receiving, holding
and storing specimen entering through said entrance;
a reaction chamber having within it a substance for reacting with
specimen entering said chamber; said chamber communicating with
said reservoir through a channel;
said channel including channel sealing means which may be actuated
to seal said channel, thereby separating all material in said
reservoir from all material in said chamber;
whereby a first portion of a specimen may pass into said chamber to
react with the substance therein and a second portion of the same
specimen may be held in the reservoir to be separately used as
needed.
2. The specimen analysis bag of claim 1, wherein
said bag, said channel and said channel sealing means are comprised
of such material and are so dimensioned that said bag may be
readily severed at the vicinity of said channel sealing means to
separate said reservoir from said reaction chamber.
3. The specimen analysis bag of claim 1 further comprising,
reservoir sealing means between said reservoir and said bag
entrance, said sealing means being actuatable to seal said
reservoir, thereby preventing entry into and exit of material from
said reservoir.
4. The specimen analysis bag of claim 3 further comprising,
adhering means around said entrance for adhering said entrance to a
source of specimen to permit gathering of specimen.
5. The specimen analysis bag of claim 1, wherein
said bag is comprised of flexible material such that manipulating
said bag displaces said bag and the material in it.
6. The specimen analysis bag of claim 5, wherein
the substance with which the specimen is to react in said reaction
chamber is stored in capsule means in said chamber; said capsule
means normally holding the substance so it is out of contact with
specimen in said chamber; said capsule means being operatable upon
to cause release of the reaction substance from said capsule means
such that the substance may react with the specimen in said
chamber.
7. The specimen analysis bag of claim 1, wherein
said reaction chamber is sub-divided into a plurality of separated
chambers, each having within it a substance for reacting with
specimen entering that said separate chamber; all of said separate
chambers communicating with said reservoir through a channel means;
said channel means including channel sealing means which may be
actuated to seal each said separate chamber from said reservoir and
from each other said separate chamber.
8. The specimen analysis bag of claim 7, wherein said separate
chambers are each isolated from one another and each includes a
separate channel communicating with said reservoir; each said
channel being provided with said sealing means.
9. The specimen analysis bag of claim 1, wherein the specimen is in
solid form,
said reservoir containing a receptacle holding solvent for the
solid specimen, whereby when solvent exits from said receptacle, it
dissolves the specimen.
10. The specimen analysis bag of claim 9, wherein said solvent
receptacle is sealed and is adapted to be opened to permit solvent
to exit therefrom by manipulation of said receptacle.
11. A method for performing at least two separate procedures on a
specimen, including the steps of,
placing a substance intended to react with the specimen in one
section of a flexible bag;
placing a specimen in another section of the bag;
transferring a first portion of the specimen from the latter
section to the former section of the bag;
sealing the bag in a manner which traps the first portion of the
specimen in the one section of the bag;
further sealing the bag in a manner which traps the second portion
of the specimen in the other section of the bag to be out of
contact with the substance which is to react with the specimen so
as to preserve the second portion for different use than the first
portion;
operating upon the first section of the bag to bring about a
reaction between the substance designed to react with the specimen
and the first specimen portion.
12. The method for performing at least two separate procedures on a
specimen of claim 11, including the additional step of severing the
bag between the sealed section thereof in which the substance to
react with the specimen is located and the other sealed section,
thereby to form two separate sealed receptacles holding
specimen.
13. The method for performing at least two separate procedures on a
specimen of claim 11, wherein the specimen is a solid specimen and
including the further steps of placing a solvent for the solid
specimen in the other section of the bag prior to placing the
specimen in that other bag section and dissolving the specimen in
the solvent before transferring the specimen to the one section of
the bag.
Description
This invention relates to a container in which a portion of a
liquid specimen, of a gaseous specimen or of a solid specimen that
has been dissolved in liquid, is stored and another portion of the
specimen is reacted with another substance, and particularly
relates to such a container comprising a flexible bag which is used
in the collection and analysis of body fluids such as urine.
It may be desired to react a liquid, or gaseous, collectively
referred to as fluid, or solid specimen with another substance. If
this reaction is inconclusive or indicates a situation meriting
further investigation, it may be desirable to have additional
specimen available for a subsequent reaction or analysis. However,
specimens may sometimes be available only on infrequent occasions.
For example, in the analysis of body fluids, such as urine,
specimens are not readily obtained and it is desirable to use one
specimen for all tests to be performed. Furthermore, it may be
desirable to perform a number of separate analysis procedures in a
single specimen.
The most common specimen collection apparatus is a simple single
chamber collection vessel which holds all of the specimen collected
from a single source. Different operations are performed on
different portions of the specimen after the specimen has been
parceled out to separate containers.
Collecting a specimen in a single container and then transferring
portions of the collected specimen to different containers for
different reaction procedures creates the possibilities of mix-up
in identification of specimens, and of contamination from the air
and from the use of a multiplicity of containers. Thus, it is most
desirable to limit the number of specimen containers, while
remaining able to perform all necessary reaction procedures and
while ensuring that there is a sufficient quantity of specimen left
over for subsequent reactions.
In other prior art specimen collection apparatus, a specimen is
divided among a number of separate chambers in a single specimen
receiving vessel. It is also known to seal off the chambers of the
vessel from each other after division of the specimen. It is
conventional to thereafter add additional substances to at least
one chamber of the vessel to bring about a particular reaction. It
is also known to permit transfer between the chambers in such a
vessel.
The prior art does not show means for providing an accurate
uncontaminated reaction with one portion of a fluid or solid
specimen while providing a container for holding another portion of
the specimen for future or other use. Also, the prior art does not
teach the provision of a substance to react with a portion of the
specimen, which reacting substance is held in a manner which
prevents contamination of the portion of the specimen not involved
in the initial reaction. The prior art contemplates the addition to
the vessel of a substance to react with a portion of the specimen
only after the specimen has been placed in the analysis vessel.
Furthermore, the prior art does not show simple means for forming a
single specimen containing vessel into at least two chambers and
for then permitting separation of the vessel into its separate
chambers so that the chamber, on whose contents a reaction is not
immediately to be performed, can be stored at a location remote
from the specimen portion on which a reaction is being performed.
Additionally, the prior art teaches the provision of reusable, and
thus specimen contaminating, vessels rather than single use
disposable vessels.
The present invention overcomes the foregoing drawbacks of the
prior art by providing a disposable, flexible, sealed specimen
collecting bag having at least two chambers. The specimen entrance
communicates with a reservoir for storage of some of the specimen.
A sealing means may be provided between the entrance to the bag and
the reservoir to permit the reservoir to be completely sealed off
at one end from the entrance to the bag.
When the specimen is a solid specimen, the reservoir is provided
with a solvent which mixes with and holds the solid specimen to
make it thereafter a liquid specimen. The solvent may be held in a
sealed container within the reservoir, which container may be
opened by appropriate manipulation of the reservoir portion of the
flexible bag. The present invention may also be used with a solid
specimen that is permitted to remain in its solid, e.g. powdery,
state until it is finally reacted with a reaction substance, as
described below.
When the specimen is gaseous, the construction of a bag in
accordance with the present invention would be substantially the
same as for a liquid specimen, except that the various entrances,
channels, seals and reaction substances described herein would have
to be designed for receiving, passing and blocking the flow of a
gas and for reacting with the gas.
The reservoir of the specimen collecting bag communicates through a
narrow channel with a reaction chamber in which a reaction is to
occur between a specimen and a reaction substance that has already
been placed in the chamber. The channel between the reservoir and
the reaction chamber is provided with preferably manually
actuatable sealing means which permits the channel to be open so
that the specimen might pass from the reservoir to the reaction
chamber and which is actuatable so as to seal the channel after
there has been adequate specimen transfer. With the channel sealed,
there are now two separate portions of specimen. The specimen
within the reaction chamber can be reacted with another substance
while the portion of the specimen in the reservoir will not be
affected by this reaction and, therefore, is available if
subsequently needed. The reaction between the specimen and the
substance to be reacted with the specimen takes place in the
reaction chamber within the bag itself.
With the bag just described, it is possible for an operator in the
field to do an immediate test on a portion of a specimen while the
remainder of the specimen remains available for later use, if
needed. For example, a nurse can do an analysis of a urine specimen
immediately after the specimen is taken, e.g. at a patient's
bedside, before the specimen changes in its characteristics. The
specimen portion in the reservoir is available should further
testing be required. Previously, a nurse or attendant had to take a
specimen to a laboratory for analysis, and there was no way of
accurately determining either the time interval between the taking
of the specimen and its analysis or the original condition of the
specimen when taken.
Should it be desirable, once the reaction chamber has been sealed
off from the reservoir, these two portions of the bag might be
separated, with the specimen holding reservoir being stored for
other or future use while a reaction is being carried out on the
specimen portion held in the reaction chamber should the specimen
contain a continuously changing substance e.g. a bacteria culture
in a urine specimen, and should it be desired to measure that
continuously changing substance at a particular instant of time,
while a reaction is being performed on the specimen portion in the
reaction chamber, the reservoir can be stored in a manner which
prevents further changing, e.g. urine would be kept refrigerated.
In the prior art, when a portion of a specimen is tested, the
remainder, if any, usually cannot readily be held in a manner that
prevents continuing change in the substance being tested in the
specimen. Thus, the provision of a readily sealable, severable, and
storable reservoir as part of the specimen receiving vessel aids in
the testing of certain changing specimens. This has the added
benefit of avoiding the need for obtaining a new supply of specimen
from the original specimen source, should further testing be
required. Thus, for example, a person would only have to supply a
single urine specimen to have a bacteria culture therein analyzed
and reanalyzed later.
It is contemplated that at the time of manufacture of the bag, the
reaction chamber will be provided with a charge of the substance
that is to be reacted with the specimen after the specimen is
received by the bag. For example, the reaction substance might be
stored in a sealed receptacle in the reaction chamber. The seal on
the receptacle could be broken after the reaction chamber has been
sealed off from the reservoir. Alternatively, the substance to
react with the specimen might mix so slowly with the specimen
itself that the reaction chamber could be sealed off before any of
such substance would improperly migrate into the reservoir. Other
ways of keeping the substance to be reacted with the specimen in
the reaction chamber and for preventing it from exiting from said
chamber into the reservoir should be apparent to those skilled in
the art.
The provision of delayed release reaction substance receptacles
permits simultaneous accurate analyses of a multiplicity of samples
taken at different times. It also permits a reaction to be delayed
until a changing specimen has attained the state at which it is to
be tested.
As an example of these benefits, a specimen, once collected, may
have to be incubated for a fixed period to bring it to a state at
which it is to be analyzed, e.g. bacteria may take 4 hours to
develop to a particular concentration. When each specimen is taken,
a portion of it can be transferred from the bag reservoir to the
bag reaction chamber. All seals are closed and the bag is
immediately refrigerated. All bags collected over a period of time
can have the sealed reservoir simultaneously removed and again
stored in the refrigerator. The sealed reaction chambers can then
be incubated all at one time under conditions that are readily
controlled. Then the reaction substance receptacles can all be
manipulated to release their contents and bring about the desired
reaction in each bag. Because the reaction substance receptacles
can hold their contents for a prolonged period, no premature
reactions occur.
With the bag of the present invention, since the specimen is all
transferred directly into a single bag, since the reaction on the
first portion of the specimen takes place in that bag, since the
substance to be reacted with the specimen has previously been
provided in the bag and, therefore, might be placed in there under
sterile conditions to prevent contamination, since a second portion
of the specimen may be stored in a reservoir that is sealed off
from the first portion of the specimen which is being reacted with
another substance in the reaction chamber, since the bag is
disposable after one use and is not reusable, and since there can
be a minimal number of transfers of specimen to different
containers, the specimen will not be contaminated, there is little
likelihood of loss of a portion of a specimen due to accident and
there is little likelihood of mix-up or misidentifications of
specimens.
The reaction chamber of the present invention is described as being
only a single chamber. It is within the contemplation of the
invention, however, to provide a plurality of reaction chambers,
arranged in series one after the other, or in parallel with each
communicating directly with the reservoir through its own separate
channel. If the reaction chambers are arranged in series, they are
joined by channels, each containing a separate sealing means. If
they are connected in parallel, channel means connect each of the
chambers and each is filled and sealed off in the manner described
above for a single reaction chamber.
The present invention will be described in connection with a body
fluid collection and analysis bag and particularly a urine
collection and diagnostic bag. It is to be understood that the
present invention may be used in conjunction with any fluid or
solid specimen and with any reaction that is performed on any
specimen.
Accordingly, it is a primary object of the present invention to be
able to divide a single fluid or solid specimen into a number of
separate portions each to be treated in a different way.
It is a further object of the present invention to provide a single
bag in which a first portion of a specimen can be reacted with
another substance and in which a second portion of the specimen can
be stored for future and other use.
It is another object of the present invention to minimize
contamination of a specimen.
It is another object of the present invention to minimize the
chances of a specimen being lost or mixed up.
These and other objects of the present invention will become
apparent from the following description of the accompanying
drawings in which:
FIG. 1 is a front view of a bag designed in accordance with the
present invention;
FIG. 2 is a fragmentary view of a bag having a reaction substance
in an alternate form;
FIG. 3 shows an alternate form of top for a bag designed in
accordance with the present invention;
FIG. 4 is a view in the direction of arrows 4 of FIG. 3;
FIG. 5 is a view in the direction of FIG. 3 with the bag being
open;
FIG. 6 is a view in the direction of arrows 6 in FIG. 3;
FIG. 7 is a view of an alternate embodiment of a bag designed in
accordance with the teachings of the present invention; and
FIG. 8 is a front view of a bag designed in accordance with the
present invention for use with solid samples.
Referring to the Figures, and particularly FIG. 1, bag 10 is a
sealed, flexible vessel which is comprised of a material, e.g.
conventional polyethylene plastic, that is inert to the liquid
specimen, to the substance to be reacted therewith and to the
reaction product. The bag is flexible to permit manual actuation of
bag sealing means and/or solvent or reaction substance retaining
means, described below, and to permit manipulation of reaction
substances, as described below. However, the bag need not be
flexible, so long as it has the qualities described below.
Sealed bag 10 has an entrance 11 for permitting urine to enter the
bag. Where the urine specimens are being taken from young children,
it is often difficult to obtain the specimen when it is desired to
collect it. Accordingly, entrance 11 is surrounded with a band of
adhesive material 12 which would adhere to the body of the child to
hold the bag in place until the specimen is provided. From entrance
11, the urine passes through an entrance chamber 14, past reservoir
sealing means 16 and into reservoir 18.
After sufficient liquid specimen has passed into and through, as
described further below, reservoir 18, it is frequently desirable
to seal off the reservoir from the bag entrance, thereby to prevent
specimen from improperly exiting from the reservoir and to prevent
contamination of the specimen in the reservoir. A conventional
sealing means 16 seals off entry portion 14 from reservoir 18. For
example, sealing means 16 might comprise a band of adhesive around
the interior wall of the bag. To actuate the sealing means, the
flexible bag is manipulated and the adhesive band is squeezed shut
and adheres to itself.
Reservoir 18 is merely a container for holding liquid specimen.
Channel 20 connects reservoir 18 with reaction chamber 22, to be
described further below. Channel 20 is defined by a block 24 of
impermeable material through which the channel passes. Channel 20
has cross-sectional dimensions such that liquid specimen would not
readily pass through it. Thus, after sealing means 16 has sealed
off reservoir 18 from entry chamber 14, then bag 10, and
specifically reservoir 18, is manipulated so that some of the
liquid within the reservoir is forced through channel 20 into
chamber 22. By manipulating only reservoir 18, specimen flows only
into chamber 22 and not back into reservoir 18, thereby preventing
contamination of the contents of reservoir 18 with any of the
materials within reaction chamber 22.
The dimensions of the reaction chamber 22 portion of bag 10 may be
so chosen that chamber 22, when filled with specimen, is holding a
predetermined volume of liquid specimen. Thus, when the specimen in
chamber 22 is reacted with a reaction substance already within the
chamber, both a qualitative and a quantitative analysis of the
reaction with the liquid specimen in the reaction chamber 22 can be
performed.
Channel 20 is also provided with a manually actuatable sealing
means for enabling the channel to be sealed after sufficient
specimen has been transferred into chamber 22. If the material of
plug 24 is sufficiently flexible to permit it, the walls of channel
20 may be coated with an inert adhesive which adheres to itself
when the walls of the channel are squeezed together. Alternatively,
other sealing means known in the art may be used. The sealing means
prevents undesired back transfer. Furthermore, should it be desired
to separate the reaction chamber 22 from the reservoir 18, the
sealing means seals off the chamber to prevent leakage.
When bag 10 is being manufactured or prior to its being put into
use, and especially prior to the entry of liquid specimen, a
substance to react with the liquid specimen is placed in the
reaction chamber 22 section of bag 10. In FIG. 1, a block 26 of
reaction material is illustrated. The block of particular volume
holds a predetermined quantity of reagent to react with the urine.
Tests for urine and reagents to react with urine are well known in
the art. See for example, "Screening Tests for Bacteria", by T. G.
Sacks and J. H. Abramson, The Journal of the American Medical
Association, Vol. 201, No. 1, July 3, 1967, p. 79, et. seq. Block
26 of reagent would be soluble in the urine or would be in a
condition where it readily mixes with the urine. Various
alternative forms for the reaction substance in chamber 22 may be
used. For example, the chamber may be holding a pool of reagent in
liquid form which reacts with the urine specimen as it enters the
chamber from reservoir 18.
In FIG. 2, the reaction substance or reagent is held in a number of
separate hollow capsules 28 which are insoluble in and impervious
to the reaction substance and to the liquid specimen. The
dimensions of the reagent capsules are such that they will not fit
through channel 20 so that they remain within chamber 22. After
channel 20 has been sealed as described above, chamber 22 is
manipulated to squeeze and burst capsules 28, thereby releasing the
reagent or reaction substance in the reaction chamber 22, so that
it can mix with the specimen which has been transferred into
chamber 22.
Alternatively, capsules 28 can be soluble in the urine at a rate
sufficiently slow that reagent is now allowed to escape from the
capsules until chamber 22 has received the desired charge of
specimen from reservoir 18 and been sealed off.
Other techniques for storing reagent in reaction chamber 22 so that
it will be available when specimen is finally transferred to this
chamber are apparent to one skilled in the art.
Since the reagent is supplied prior to use of the bag, once the
reagent is exhausted after one use of the bad, the bag is disposed
of. This nonreusability feature minimizes specimen
contamination.
At any time after specimen is in both reservoir 18 and reaction
chamber 22, should it be desired to separate the reservoir from the
reaction chamber, so that reservoir 18 might be stored, e.g. under
refrigeration, while a reaction takes place in the reaction chamber
22, plug 24 and sealed channel 20 may be cut through along
predetermined cutting path 30 by conventional cutting means thereby
separating sealed chamber 22 from sealed reservoir 18. Bag 10 may
be weakened along path 30 to facilitate separation. If the test
performed in reaction chamber 22 shows a particular result, e.g.
the presence of an undesired bacteria, the still sterile urine in
reservoir 18 may be subjected to further bacterial testing. Also,
should anything unforeseen damage reaction chamber 22 or the
quality and purity of the specimen therein, the portion of the
specimen still in reservoir 18 is available for repeat testing
using the same reaction substances.
Once reservoir 18 is sealed off at sealing means 16, bag entrance
11 and entry portion 14 are no longer necessary and the bag may be
cut off along predetermined cutting path 32 above the sealing means
16 thereby eliminating unnecessary material and providing a compact
reservoir 18. Bag 10 may also be weakened along path 32 to
facilitate separation.
In FIGS. 3-6 is shown an alternate entrance for a bag 40. Since bag
40 could be the same as the bag 10 in all other respects, only the
entrance to bag 40 is described. Entrance 42 opens across the
entire top of bag 40. Resilient sealing rib 44 along one side of
thickened resilient cuff 43 and depression 45 along the opposite
side of cuff 43 engage one another and cooperate to hold entrance
42 shut, as shown in FIG. 3. Pressure on the ends 46 of cuff 43
causes the cuff to bow into a rounded opening. Release of this
pressure will permit entrance 42 to again close.
FIG. 7 shows a bag 50 which is comprised of the same elements as
bag 10 except for the reaction chamber means. Sealing means 52
seals off the inlet end of reservoir 54, which reservoir has the
qualities of reservoir 18. Reaction chamber means 56 includes a
plurality of reaction chambers 58, 60, 62, 64, each of which is
sealed off and isolated from its neighboring reaction chamber by
intermediate walls 66.
Reaction chamber 58 will be described in detail, it being
understood that the other chambers are substantially identical.
Chamber 58 has a plug 68 of the same type as plug 24. Plug 68 has a
channel 70 passing through it, which channel is of the same type as
channel 20 and which channel is provided with a sealing means of
the type provided in channel 20. Positioned within the reaction
chamber 58 is a reaction substance 72, similar to that in bag 10.
Before a reaction occurs within an individual reaction chamber, the
channel into that chamber should be sealed off in the manner
described above, thereby isolating the chamber completely from the
reservoir 54 and from the other chambers. Once an individual
reaction chamber is isolated from the others and from the
reservoir, it is effectively the same as reaction chamber 22.
With the provision of a plurality of reaction chambers, rather than
just one, a number of separate tests can be performed
simultaneously on a single specimen, while a separate portion of
that specimen is stored for other or later use in the separate
sealed reservoir 54.
As with the reaction chamber 22, the reaction chambers 58-64 may be
separated from the reservoir 54 by cutting across the bag 50 along
predetermined cutting path 73 through the sealing plugs into each
reaction chamber. Also, if the walls 68 between neighboring
reaction chambers are made thick enough, it would be possible to
separate neighboring chambers by cutting along the dividing
wall.
In the event that the specimen is in the form of a solid, rather
than in the form of a liquid, the embodiments of the present
invention which are shown in FIGS. 1-7 may still be employed. If
the solid specimen is already in particles that are sufficiently
small to fit through the entrance to the bag and through the
channel or channels leading into the reaction chamber or chambers,
then, as with the liquid specimen, a portion of the solid specimen
is stored in the reservoir and a portion of the specimen passes
into the reaction chamber to be reacted with a reaction substance
or reagent stored in the chamber. The reaction substance would have
to be in a form which would mix with, dissolve and react with the
solid specimen so as to provide a measurable reaction.
Should the solid specimen be in particles too large to be properly
stored, passed through the channels of the bag or reacted with a
reaction substance, or should it be desirable to store and work
with a specimen that has been placed in liquid form, then the
modified bad 80 of FIG. 8 would be used.
Bag 80 has an entrance (not shown) and a reservoir entrance sealing
means 82 both of the type described above. Within the reservoir 84
is positioned a solvent holding receptacle 86, which may be a
freely movable solvent filled bubble or a bubble that is secured to
the interior wall of the reservoir. Usually, the receptacle 86
would be sealed to prevent leakage of reagent out of the bag 80
before the reservoir has been sealed at 82. The solvent in
receptacle 86 would be any conventional solvent, e.g. water or
alcohol, which is adapted to dissolve and mix with the solid
substance to be analyzed. Once dissolved in liquid solvent, the
solid specimen becomes identical to a liquid specimen provided for
storage and reaction and the treatment of this now liquid specimen
would be the same as described above. The remaining structure of
bag 80 is illustrated as being similar to that shown in FIG. 2,
and, therefore, it will not be described. Structures in FIG. 8 that
are described with respect to FIG. 2 are correspondingly numbered
to FIG. 2 with prime (') numbers.
For gaseous specimens, a modified bag structure of FIGS. 1-7 could
be used. The modifications would be in the size of the bag
entrance, the width of the channel between the reservoir and the
reaction chamber, the type of sealing means used in the bag and the
type of reaction substance, e.g. a material to absorb gas, used in
reaction chamber. The necessary modifications should now be
apparent to one skilled in the art.
There has just been described a novel bag for receiving and holding
a single fluid or solid specimen, and for permitting a reaction to
be performed on a portion of that specimen which is isolated from a
second portion of that specimen which second portion is held in a
sterile storage reservoir until that second portion is
required.
Although preferred embodiments of this novel invention have been
described, many variations and modifications will now be apparent
to those skilled in the art. Therefore, this invention is to be
limited, not by the specific disclosure herein, but only by the
appended claims.
* * * * *