U.S. patent number 3,657,744 [Application Number 05/035,815] was granted by the patent office on 1972-04-25 for method for fixing prosthetic implants in a living body.
This patent grant is currently assigned to The Regents of the University of Minnesota. Invention is credited to Robert A. Ersek.
United States Patent |
3,657,744 |
Ersek |
April 25, 1972 |
METHOD FOR FIXING PROSTHETIC IMPLANTS IN A LIVING BODY
Abstract
A device and method for facilitating the rapid positive fixation
of implanted prosthetic members in a living body. The device
comprises a tubular sleeve of deformable material to which the
prosthetic member is secured and which is capable of being expanded
radially into intimate engagement with surrounding tissue. The
fixation device and prosthetic member, such as heart valve, vessel
graft, etc., are prepared by assembly prior to surgery. The
assembly may be rapidly introduced into the transplant situs during
surgery and secured in place by expansion of the deformable sleeve
by use of an expansion tool.
Inventors: |
Ersek; Robert A. (St. Louis
Park, MN) |
Assignee: |
The Regents of the University of
Minnesota (Minneapolis, MN)
|
Family
ID: |
21884932 |
Appl.
No.: |
05/035,815 |
Filed: |
May 8, 1970 |
Current U.S.
Class: |
128/898; 606/153;
623/902 |
Current CPC
Class: |
A61B
17/11 (20130101); A61F 2/954 (20130101); A61F
2/07 (20130101); A61F 2/89 (20130101); A61F
2002/075 (20130101); A61F 2/856 (20130101); A61F
2220/0075 (20130101); A61F 2002/061 (20130101); A61F
2/9517 (20200501); A61F 2/90 (20130101); Y10S
623/902 (20130101); A61F 2002/065 (20130101); A61F
2/2412 (20130101) |
Current International
Class: |
A61B
17/11 (20060101); A61F 2/06 (20060101); A61B
17/03 (20060101); A61F 2/24 (20060101); A61f
001/22 (); A61f 001/24 () |
Field of
Search: |
;128/334R,334C,341,343,348 ;3/1,DIG.1,DIG.3 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
Primary Examiner: Gaudet; Richard A.
Assistant Examiner: Frinks; Ronald L.
Claims
The embodiments of the invention in which an exclusive property or
privilege is claimed are defined as follows:
1. A method for rapidly and positively fixing an inplanted
prosthetic device in a living body which comprises:
A. securing the prosthetic device to be implanted to at least one
openwork tubular sleeve of non-toxic deformable material compatible
with body fluids and capable of being expanded radially, said
sleeve being of a diameter corresponding to the prosthetic member
to be implanted and adapted for attachment to the prosthetic
member, and including a plurality of longitudinally extending
ribbon-like undulating portions disposed angularly with respect to
the perimeter of said sleeve and interconnected to define a
plurality of staggered closely spaced apertures,
B. introducing the sleeve and prosthetic device into a prepared
transplant situs, and
C. expanding the sleeve radially outwardly against the tissue walls
of said situs and forcing the undulating ribbon-like portions of
the sleeve into intimate engagement therewith, whereby the tissue
may grow through and around the sleeve to cover the same.
2. A method according to claim 1 further characterized in that:
A. said prosthetic device to be implanted is a vessel graft,
B. said openwork sleeve is inserted partially and secured in each
end of said vessel graft leaving an exposed portion of sleeve
extending therefrom,
C. said graft is provided with a longitudinal opening to receive a
sleeve expanding tool;
D. said prosthetic device and sleeves are joined to the host
vessels to be grafted by introduction of the exposed portions of
said sleeves into the severed host vessels, and
E. the sleeves are expanded radially outwardly into intimate
engagement with the walls of said vessels and said graft.
3. A method according to claim 1 further characterized in that:
A. said prosthetic device to be implanted is a heart valve,
B. said valve is secured within one end of said sleeve,
C. said sleeve and valve are introduced into the situs of the
defective valve to be replaced, and
D. said sleeve is expanded into engagement with the surrounding
tissue.
Description
This invention relates to a device and method for the rapid
positive fixation of implanted prosthetic members in a living
being. Many thousands of implants of prosthetic members, either
artificial members or homografts or grafts from other animal
species are made annually. Vessel grafts and heart valve implants
are becoming commonplace. Transplantation of large organs such as
the heart, lungs, liver, etc. is taking place in ever increasing
numbers.
The fixation device according to the present invention comprises a
tubular sleeve of deformable material to which the prosthetic
member is secured and which is capable of being expanded radially
into intimate engagement with the tissue surrounding the implant
situs. It has been found through animal experimentation that the
implant may be made rapidly and positively, without fear of
dislodgment or leakage. When formed of a compatible material, the
fixation device is well tolerated by the body and becomes
completely covered by tissue leaving no exposed surface for the
formation of clots and thrombi.
According to the prior art, artificial heart valves are installed
by the careful placing of a plurality of stitches around the rim of
tissue that will house the valve. These stitches are passed through
a suture ring around the outside of the heart valve. The valve to
be implanted is held outside of the heart 6 or 8 inches and each
stitch is brought up through the suture ring while the valve is
still so held. When the sewing is finished, the valve stands some
distance above the heart and has 20 or 30 sutures going down to the
tissue where it will finally rest. The sutures are held tight and
the heart valve is slid down them into place and each suture is
then individually tied. This process takes 30 to 45 minutes in the
best hands and from an hour to an hour and one-half in the less
then best.
In the case of the transplantation of a graft valve from another
patient or from an animal, sewing takes more than an hour. Although
excellent results have been reported with these transplanted
valves, few surgeons are using them today because of the great time
that must be taken to sew them in. Valve installation takes place
while the patient is on an artificial heart-lung machine and every
minute is very important.
One form of prior art heart valve is available wherein a caged ball
valve is provided in its outer rim with a plurality of radially
extending teeth which by screw means are caused to engage the
aortic wall. Such valves, though expensive, are satisfactory where
there is a very tight initial fit and where the aortic wall is of
uniform consistency and size, conditions which cannot always be
depended upon to exist. Accordingly, problems have arisen relating
to aortic incompetence due to blood flow working its way between
the prosthesis and the aortic wall in the many instances where no
positive fixation is achieved by the tooth members.
The device of the present invention permits instant and positive
fixation of heart valves, vessel grafts and other prosthetic
members. The valve or other prosthetic member is prepared for
implantation by attachment to the openwork sleeve. The valve and
its skirt composed of the sleeve is assembled on an expanding tool
device. This assembly can be quickly and easily forced into place
and the tubular sleeve expanded to hold the valve or other member
in place. This is done in a small fraction of the time required for
other transplants so that in many instances use of the heart-lung
machine is not required. The fixation sleeve expands so that a snug
fit is assured regardless of the size, shape or consistency of the
tissue wall at the implantation situs. Since the sleeve becomes
incorporated into the tissue wall, no foreign material is left in
contact with the blood, as opposed to prior art devices.
The invention is illustrated by the accompanying drawings in
which:
FIG. 1 is a schematic view showing three stages of the grafting of
an artificial bifurcation vessel graft utilizing the fixation
device according to the present invention;
FIG. 2 is a perspective schematic view of one modified form of
prosthetic fixation device;
FIG. 3 is a perspective view of another modification;
FIG. 4 is a perspective view of a further modification;
FIG. 5 is a schematic representation of a portion of the perimeter
of any one of the devices of the preceding FIGS., as seen in
transverse section;
FIG. 6 is an elevation of one form of expanding tool which may be
utilized with the fixation device;
FIG. 7 is a fragmentary elevation of the operating end of the
expanding tool showing the tool in expanded condition;
FIG. 8 is a perspective elevational view with the upper half of the
fixation device in section, and showing the fixation device with a
heart valve attached for implantation; and
FIG. 9 is a top plan view of the assembly of FIG. 8.
Referring to the drawings, and particularly to FIG. 1, there is
shown schematically one manner in which the prosthesis fixation
device according to the present invention is used. This use is
illustrated with respect to the implantation of an artificial
bifurcated aortic Dacron graft, indicated generally at 10, between
the severed aorta 11, shown with a Satinsky clamp preventing flow,
and the common iliac arteries 13 and 14. A completed joint is shown
between the artery 13 and one branch 15 of the artificial vessel
transplant. The ends of the artery and prosthesis are in butting
relation held by an expanded fixation sleeve, indicated generally
at 16, within the host-prosthesis junction. A similar sleeve 16 is
shown partially within the branch 17 of the prosthesis 10 about to
be connected to the artery 14.
The manner in which the junction is made is shown with respect to
the severed end of the aorta 11. An expandable sleeve fixation
device 16 is shown extending from the end of the artificial vessel
graft 10 with about half of its length engaging the inside wall of
the graft. The head of an expander tool, indicated generally at 18,
whose tubular barrel 19 extends through a slit 20 in the graft, is
positioned within the sleeve. A tapered tip 21 placed on the end of
the expanding tool facilitates entry of the assembled graft, tool
and fixation device 16 into the aorta. When in place, with the ends
of aorta 11 and graft 10 butting, the sleeve is expanded by
operation of the expanding tool to force the fenestrations of the
sleeve into the wall of the aorta to achieve a leak-proof union and
forcing the walls of the sleeve into tighter engagement with the
inside wall of the graft 10.
After the sleeve is expanded, the tool is withdrawn. A smaller
headed tool is inserted through slit 20 from the opposite direction
to within the fixation device 16 of lesser diameter for connection
with artery 14. The exposed end of sleeve 16 is inserted into the
lumen of the artery 14 and the sleeve is expanded to make the
joint. The tool is withdrawn, slit 20 is clamped shut and clamp 12
is removed to permit resumption of blood flow. The entire
transplant can be made in a matter of a very few minutes to the
point of restoration of the blood supply. The longitudinal slit in
the graft may then be sewn closed at leisure in confidence that the
blood is being supplied distal to the graft site.
The tubular sleeve 16 is made of deformable material such that it
retains its expanded dimensions after expansion in place. It is
formed from a non-toxic material compatible with blood and other
body fluids, such as stainless steel. Its walls desirably have a
large percentage of open area so as to permit proliferation of the
intima of the vessels through the openings and over the intervening
strand-like or ribbon-like members. Preferably the openwork sleeve
is formed from so-called "expanded metal" sheeting which is
produced by forming a series of staggered parallel slits in an
impervious metal sheet and then stretching the sheet in a direction
perpendicular to the slits to open the slits into apertures and
expand the metal sheet in that direction while contracting it
slightly in the opposite direction. The stretching operation by
which the metal sheet is expanded imparts a twist or bend to the
undulating flat ribbon-like portions 22 of the metal sheet
separating the diamond-shaped apertures 23 which are generally
uniformly sized and distributed. This twisting or bending of the
metal members 22 between adjacent apertures imparts an angle or
direction to the apertures themselves and to the ribbon-like
members.
The expanded metal sheeting is desirably not flattened prior to
forming into a sleeve. The result, as seen schematically in FIG. 5,
is that the ribbon-like portions 22 of the sleeve extend angularly
relative to the perimeter of the sleeve providing a multitude of
narrow projecting edges which embed themselves into the tissue wall
upon expansion of the sleeve. After being formed with the members
22 extending generally longitudinally, the sleeve is desirably spot
welded to form a longitudinal seam. The tubular sleeve may be
circular, oval, or polygonal (hexagonal, octagonal or the like) in
cross-section. The cross-sectional area may be uniform along the
length of the sleeve or it may vary, giving the sleeve generally a
barrel shape or that of a truncated cone. The edges may be cuffed
if desired or simply smoothed to facilitate entry. The sleeve may
easily be expanded by about 50 percent beyond its original
diameter. The sleeves are formed to be a size appropriate for the
implant being made. The strands 22 and apertures 23 are sized
proportionately.
Because of the twisted relation of the ribbon-like portions of the
sleeve, protrusion of the vessel lining is facilitated with the
result that very little metal is actually in contact with the blood
stream. Experimentally it has been determined that within a few
seconds a fine clot layer is laid down over the stainless steel
struts forming a physiological bridge from the islands of intima
where the vessel lining protrudes through the apertures in the
sleeve.
Instead of metal, the tubular fixation sleeve may be formed from
other natural or synthetic materials having the requisite
properties and characteristics permitting the sleeve to be expanded
into secure attachment with surrounding tissue. Desirably the
material is one which is capable of being absorbed over an extended
period of time by the tissue to which the sleeve is attached. A
number of such absorbable materials are known.
In the form of fixation device shown in FIG. 2, sleeve 16A is
provided with a plurality of circular holes 24 (which are of larger
area than apertures 23) punched through the openwork wall around
the sleeve adjacent one end to allow for the ostia of the coronary
arteries.
In FIG. 3, a modified form of sleeve 16B is provided with a
plurality of relatively large rectangular openings 25 extending
longitudinally to permit exposure of wide areas around the coronary
artery ostia. This form of fixation device is intended for the
implantation of heart valves. The valve is hung with its
commissures secured along the upper and lower ring portions 26 and
27, respectively, whose widths are about one-eighth to one-fourth
the length of the sleeve.
In FIG. 4, the fixation device includes a plurality of longitudinal
wire struts 28 separating two expandable and relatively narrow
metal mesh ring sections 29 and 30. A three-pronged commissure
valve is inserted in the upper expandable ring section 29 and
secured to the bottom mesh ring 30 circumferentially.
A variety of expanding devices may be used to set the fixation
devices in place. One form of such tool is shown in FIG. 6. The
device includes a pistol-grip handle 31 and a trigger-like
operating lever 32 pivoted therein. An elongated tubular barrel 19
extends out from the handle means. A concentric rod 33 extends
through the handle 31 and barrel 19 terminating in a fitting 34
beyond the muzzle end of barrel 19 at its forward tip. Expansion
means, comprised of a pair of resilient rings 35, each held between
a pair of washers 36 and held spaced apart by a rigid spacer ring
37, are disposed between the muzzle end of barrel 19 and tip
fitting 33. Operation of the lever 32 by gripping and squeezing to
move it toward the handle causes rod 33 to shorten its exposed
length in relation to barrel 19 such that squeezing force causes
the resilient rings to decrease their longitudinal dimensions.
Being non-compressible, they expand radially outwardly increasing
their lateral dimensions, as shown in FIG. 7. In this way, a
predictable dependable amount of expansion can be achieved. The
breech end of rod 33 is threaded and fitted with a knurled knob 38.
The heel 39 of operating lever 32 bearing against a spacer tube 40,
which in turn bears against knob 38, causes the relative movement
between barrel 19 and rod 33. Alternatively, force may be exerted
simply by rotation of knob 38 and adjustment of the at-rest force
exerted upon the expansion rings may be made. One, two or more
expandable rings 35 may be used. The pattern of expansion can be
predetermined as desired by selection of appropriate spacing
between those rings.
When used for the installation of artificial vessel grafts made of
Dacron, Teflon or similar artificial materials, the fixation sleeve
is attached to the vessel graft some time prior to surgery and a
longitudinal slit is made in the middle of the graft for the
introduction of the expansion tool. At the time of surgery, the
ends of the vessel to be grafted are secured through simple stay
stitches or small clamps so that the fixation sleeve can be
introduced thereto. The expander tool is in place in one of the
sleeves at the time of introduction. This sleeve is then expanded
in situ and the expander tool is removed through the longitudinal
slit, turned around and used to expand the fixation sleeve at the
other end and again removed. The longitudinal slit is clamped and
the clamps or stitches securing the vessels to be grafted are
removed to restore the blood flow. Very rapid fixation of vessel
grafts is thus possible.
In FIG. 8 there is shown an aortic heart valve 45 in place in a
fixation sleeve 16. The rim of valve 45 adjacent the cusps 46 is
attached by sutures 47 to the sleeve near one end. A segment of the
donor aorta 48 is attached by sutures 49 near the other end of
sleeve 16. The opening 50 in the aorta wall for a coronary artery
can be matched with the corresponding opening in the wall of the
donee aorta.
When used for the fixation of heart valves, whether a transplant or
artificial, the valve is secured within the fixation sleeve prior
to surgery and the sleeve is assembled in the expansion tool. Then,
at the time of surgery, the sleeve is rapidly expanded into place
and the tool withdrawn. When used for implantation of heart valves
in the aortic position, a total introduction time of only a few
minutes is necessary. This means that an aortic valve may be placed
without use of a heart-lung machine. Inflow of blood into the heart
is occluded by placing clamps across the appropriate vessels. A
longitudinal slit (aortotomy) is placed in the aorta just a few
centimeters above where it begins. This slit is opened and the
existing defective valve is removed. The new valve housed in the
expandable sleeve is then placed in position and the sleeve is
expanded in one stroke of the expanding tool. The expansion tool is
then removed through the aortic slit and a clamp placed over it,
thus allowing the restoration of blood flow so that only a few
minutes total introduction time is required. The aortotomy can then
be repaired at leisure after the heart has taken over its pumping
function.
It is apparent that many modifications and variations of this
invention as hereinbefore set forth may be made without departing
from the spirit and scope thereof. The specific embodiments
described are given by way of example only and the invention is
limited only by the terms of the appended claims.
* * * * *