U.S. patent number 3,655,985 [Application Number 04/826,224] was granted by the patent office on 1972-04-11 for radiation-shielding receptacle for a bottle for receiving a radioactive eluate.
This patent grant is currently assigned to Mallinckrodt Chemical Works. Invention is credited to James L. Brown, Donald T. Himebaugh, James R. Montgomery.
United States Patent |
3,655,985 |
Brown , et al. |
April 11, 1972 |
RADIATION-SHIELDING RECEPTACLE FOR A BOTTLE FOR RECEIVING A
RADIOACTIVE ELUATE
Abstract
A radiation-shielding receptacle for holding a glass bottle for
receiving the eluate from the elution of a radioactive material is
disclosed. The receptacle includes a hollow cylindric body of
nontransparent radiation-shielding material having a window opening
in its wall. A first end closure of radiation-shielding material is
provided at one end of the body and a second end closure of
radiation-shielding material is provided at the other end of the
body. The second end closure has a central opening therein smaller
than the internal diameter of the body and of a size so that the
mouth of a bottle positioned in the body is exposed to receive the
eluate. An insert of substantially transparent radiation-shielding
material is secured in and fills the window opening so that the
eluate in a bottle in the body may be viewed from the outside. The
thickness of the body and the thickness of the insert are
sufficient to provide a substantial amount of shielding against
radioactive emission from the eluate.
Inventors: |
Brown; James L. (St. Louis
County, MO), Himebaugh; Donald T. (Ballwin, MO),
Montgomery; James R. (St. Louis County, MO) |
Assignee: |
Mallinckrodt Chemical Works
(St. Louis, MO)
|
Family
ID: |
25246015 |
Appl.
No.: |
04/826,224 |
Filed: |
May 20, 1969 |
Current U.S.
Class: |
250/506.1; 600/5;
976/DIG.350; 206/459.1 |
Current CPC
Class: |
G21F
5/015 (20130101) |
Current International
Class: |
G21F
5/015 (20060101); G21F 5/00 (20060101); G21f
005/00 () |
Field of
Search: |
;250/16S,18WS,72 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Lawrence; James W.
Assistant Examiner: Frome; Morton J.
Claims
What is claimed is:
1. A radiation-shielding receptacle for holding a transparent
vessel having a neck for receiving the eluate from the elution of a
radioactive material, said receptacle comprising a hollow body of
nontransparent radiation-shielding material having upper and lower
end closures of radiation-shielding material, one of said end
closures being removably attached to said body, the upper end
closure having a central opening therein smaller than the internal
cross section of the body and extending completely through said
upper end closure for receiving the neck of the vessel with the
neck extending upwardly out of the receptacle through said opening
for access to the mouth of the vessel for the elution operation,
the wall of said body having an elongate window opening therein
extending in the direction of the height of the body, and an insert
of substantially transparent radiation-shielding material in said
window opening for viewing of the eluate in a vessel in the
receptacle while shielding against radioactive emission from the
eluate.
2. A radiation-shielding receptacle as set forth in claim 1 wherein
the lower end closure is removably attached to the body.
3. A radiation-shielding receptacle as set forth in claim 2 wherein
the body is of hollow cylindric form and the lower end closure is
threaded in the lower end of the body.
4. A radiation-shielding receptacle as set forth in claim 3 wherein
the upper end closure is constituted by an integral inwardly
directed annular flange at the upper end of the body.
5. A radiation-shielding receptacle as set forth in claim 4 wherein
the body is made of lead and has an internally threaded ring of a
harder metal than lead secured therein at its lower end, and the
lower end closure comprises a plug of lead having an externally
threaded ring of a harder metal than lead secured therearound and
threaded in the internally threaded ring.
6. A radiation-shielding receptacle as set forth in claim 5 wherein
the plug has a flange extending outwardly below the externally
threaded ring.
7. A radiation-shielding receptacle as set forth in claim 1 having
a removable cover of radiation-shielding material overlying the
upper end closure.
8. A radiation-shielding receptacle as set forth in claim 1 for
holding a glass bottle having a neck wherein the opening in the
upper end closure is larger than the neck and the height of the
receptacle is such that the neck extends upwardly through the
opening.
9. A radiation-shielding receptacle as set forth in claim 8 wherein
the body is of hollow cylindric form, the upper end closure is
constituted by an integral inwardly directed annular flange at the
upper end of the body, and the lower end closure is constituted by
a plug threaded in the lower end of the body.
10. A radiation-shielding receptacle as set forth in claim 9
wherein the window opening is constituted by a slot extending down
from the upper end of the body terminating short of the lower end
of the body.
11. A radiation-shielding receptacle as set forth in claim 10
wherein the body and closures are made of lead, and the insert is
made of lead glass.
12. A radiation-shielding receptacle as set forth in claim 11
wherein the insert is thicker than the wall of the body.
13. A radiation-shielding receptacle as set forth in claim 12
having a cover of radiation-shielding material for the upper end of
the receptacle, the latter having an annular rib around the central
opening therein and the cover having a recess for receiving the rib
and the upper end of the neck of the bottle.
Description
BACKGROUND OF THE INVENTION
This invention relates to the containerization of radioactive
isotope solutions and more particularly to the containerization
under sterile conditions of such solutions obtained as the eluate
in a radioisotope generator.
The invention is particularly concerned with the preparation and
packaging, in a sterile system, of a solution of a daughter
radioisotope, such as technetium-99m, generated from a parent
radioisotope such as molybdenum-99. Conventionally, the preparation
of a daughter radioisotope from a parent radioisotope is carried
out by solvent extraction using a generator containing the parent
radioisotope on an ion exchange medium or other medium, such as
alumina, having a high adsorptive capacity for the parent
radioisotope but a low adsorptive capacity for the daughter
radioisotope. The desired daughter radioisotope is eluted by
washing with a suitable solvent or eluant such as a sterile,
pyrogen-free isotonic saline solution. The resultant eluate
containing the daughter radioisotope in the form of a dissolved
salt is useful as a diagnostic agent and is adapted for intravenous
administration.
The generator containing the parent radioisotope adsorption medium
for eluting the daughter radioisotope is frequently referred to in
the art as a "cow" and the elution of the daughter radioisotope
therefrom is generally referred to in the art as "milking the
cow."
Some daughter radioisotopes widely used in medical diagnosis have
relatively short half lives, e.g., 6 hours, and it is important
that they be generated or prepared shortly before use in a
hospital, clinic or other place of usage. Thus, there is need for
apparatus to generate and containerize the eluate under sterile
conditions once a day in a hospital or clinic. This must be under
conditions wherein the user of the apparatus is afforded maximum
protection against radioactive emission from the generator. The
apparatus must also be relatively simple and easy to use so that
hospital technicians, rather than highly trained experts, can
perform the operation.
Conventionally, the eluate is received in a vessel (e.g., a glass
bottle) which is inserted in a lead cup or a cup of other shielding
material. In such an arrangement, it is difficult for the operator
of the equipment to tell exactly when the vessel has received the
desired amount of eluate. Sometimes, the vessel is filled and then
placed in the shielded cup. In this case, the technician can
observe the level of the eluate in the vessel as it fills, but
there is a resultant radiation hazard until the vessel is placed
within the shielded cup.
Accordingly, the prior-art arrangement has not been wholly
satisfactory because of the difficulty in filling the vessel with
eluate to a desired level without undesirable radiation leakage.
Since the decay characteristics of most of the parent-daughter
radioisotope combinations presently in large-scale use require that
the generator or cow be milked daily, the use of the prior-art
techniques and devices undesirably involve daily exposure of the
operator to radioactivity during the milking operation.
SUMMARY OF THE INVENTION
It is an object of the instant invention to provide an improved
receptacle for holding the vessel for receiving the eluate which
will minimize the radiation hazards and at the same time permit the
level of the eluate to be observed so that the vessel can be filled
to the desired level. Desirably, the apparatus will also minimize
operator handling and exposure. The apparatus is also easy and
economical to use.
The invention involves a radiation-shielding receptacle for holding
a substantially transparent vessel for receiving the eluate from
the elution of a radioactive material which comprises a hollow body
of nontransparent radiation-shielding material having a window
opening in its wall. A first end closure of radiation-shielding
material is provided at one end of the body, and a second end
closure of radiation-shielding material is provided at the other
end of the body. The second end closure has a central opening
therein so that the mouth of a vessel positioned in the body is
exposed to receive the eluate. An insert of substantially
transparent radiation-shielding material is secured in and fills
the window opening so that the eluate in a vessel in the body may
be viewed from the outside. The thickness of the body and the
thickness of the insert are sufficient to provide a substantial
amount of shielding against radioactive emission from the eluate
for the user. The second end closure desirably is an integral part
of the body, with the result that the vessel is inserted into the
body from the other end. In this case, the first end closure is
conveniently threaded into the body or is detachably secured in
some other manner. If desired, a cover or lid of
radiation-shielding material adapted for placement over the second
end closure may be used so as to provide shielding for the opening
in the second end closure and so that the mouth of the vessel
positioned in the body may also be shielded. Other objects and
features will be in part apparent and in part pointed out
hereinafter.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a view in elevation of a receptacle made according to the
invention, showing a cover therefor raised from the receptacle;
FIG. 2 is a plan view of the receptacle on line 2--2 of FIG. 1;
FIG. 3 is a bottom plan of a cover, taken on line 3--3 of FIG.
1;
FIG. 4 is a vertical cross section of a receptacle, showing a
bottle in place therein;
FIG. 5 is a horizontal section on line 5--5 of FIG. 6; and
FIG. 6 is a view in elevation of a receptacle with the cover in
place.
Corresponding reference characters indicate corresponding parts
throughout the several views of the drawings.
DESCRIPTION OF THE PREFERRED EMBODIMENT
Referring to the drawings, a radiation-shielding receptacle made
according to this invention is shown to comprise a hollow cylindric
body 1. This has an elongate window opening or slot 3 extending
through its wall in the direction of its height. Body 1 is made of
an appropriate radiation-shielding material such as lead. A first
end closure or cap 5 of radiation-shielding material, for example,
the same material as the cylinder, is provided at one end (the
lower end) of the body. As illustrated, the first cap 5 is a plug,
e.g., of lead threaded in the lower end of the body. If the
materials are very soft, as is lead, externally threaded ring
insert 25 and internally threaded ring insert 27 of harder material
such as steel can be used to provide the mating threads for
threading the cap 5 into body 1. The inserts 25 and 27 can be
attached to body 1 and to cap 5, respectively, in any appropriate
manner. The plug has a flange 29 extending outwardly below the
internally threaded ring insert 27.
A second end closure or cap 7 of radiation-shielding material is
provided at the other end (the upper end) of body 1. The second cap
7 has a centrally disposed opening 9 therein smaller than the
internal diameter of the body 1 and of a size so that the neck 21
and mouth 23 of a vessel 11 positioned in body 1 can protrude
through opening 9 so that mouth 23 is exposed to receive the
eluate. Second cap 7 is shown as integral with the body 1. This can
be conveniently done by making second cap 7 and cylinder 1 as a
one-piece casting so that the second end closure is constituted by
an integral inwardly directed annular flange at the upper end of
the body. In this arrangement, the substantially transparent vessel
11 has to be inserted into the body 1 from the lower end, which is
then closed by first cap 5.
The vessel 11 is generally a glass bottle having calibration marks
on the side thereof to indicate the amount of eluate therein. An
insert 13 of substantially transparent radiation-shielding material
such as a lead glass is secured in and fills the window opening or
slot 3. The vessel 11, the eluate therein and the calibration marks
thereon may be viewed from the outside of body 1 through window
insert 13. The thickness of the insert 13 and the thickness of the
body 1 desirably are sufficient to provide a substantial amount of
radiation shielding for the user. Normally window insert 13 will
have a thickness greater than the thickness of the wall of body
1.
In the embodiment shown in the drawings, the second cap 7 has an
annular rib or ridge 15 extending upwardly therefrom. Desirably,
the ridge is of a sufficient height to extend beyond the neck 21
and mouth 23 of a vessel 11 positioned in cylinder 1. A lid or
cover 17, having a recess 19 therein of a size sufficient to
completely receive ridge 15, is provided to be positioned on top of
second cap 7. When cover 17 is in position, the top of body 1,
including the neck 21 and mouth 23 of the vessel 11 positioned
therein, is covered. Cover 17 desirably is formed of the same
radiation-shielding material as is body 1, and is of a thickness
sufficient to provide a substantial amount of radiation shielding
for the user of the equipment.
In accordance with the instant invention, the vessel 11 can be
inserted in the body 1 and the bottom closed before the milking
operation commences. The shielded vessel can then be positioned to
receive the eluate. The level of the eluate can be observed at all
times through the insert 13 in the wall of the body. When the
operation is completed, it is not necessary to handle the vessel at
all. Rather, it can be transported in the radiation-shielding
receptacle where needed. If desired, the cover 17 may be applied to
the body to provide still further radiation shielding because of
the possibility of some emission of radiation from the exposed
mouth and neck of the vessel 11. The lower closure 5 is made
removable for ready shielded transfer of the vessel 11 from the
body 1 to an assay shield such as shown in the copending coassigned
application of Lloyd G. Struttman, Ser. No. 658,788, filed Aug. 7,
1967, issued as U.S. Pat. 3,506,832 Apr. 14, 1970, by allowing the
vessel to slide out of the body 1 into the assay shield.
In view of the above, it will be seen that the several objects of
the invention are achieved and other advantageous results
attained.
As various changes could be made in the above constructions without
departing from the scope of the invention, it is intended that all
matter contained in the above description or shown in the
accompanying drawings shall be interpreted as illustrative and not
in a limiting sense.
* * * * *