U.S. patent number 3,653,385 [Application Number 05/082,366] was granted by the patent office on 1972-04-04 for production of focal brain lesions by inductive heating.
Invention is credited to Charles Burton.
United States Patent |
3,653,385 |
Burton |
April 4, 1972 |
PRODUCTION OF FOCAL BRAIN LESIONS BY INDUCTIVE HEATING
Abstract
A metallic pellet or seed is physically implanted into the brain
in a position where a brain lesion is to be produced. The seed is
composed of a metallic alloy of predetermined composition capable
of being inductively heated by radio frequency energy. By virtue of
the composition of the alloy, the seed reaches but does not exceed
a predetermined temperature, and the desired size and degree of
lesion is controlled as a function of time during which the radio
frequency field is in operation.
Inventors: |
Burton; Charles (Gladwyn,
PA) |
Family
ID: |
22170754 |
Appl.
No.: |
05/082,366 |
Filed: |
October 20, 1970 |
Current U.S.
Class: |
606/27; 600/2;
607/113; 600/10 |
Current CPC
Class: |
A61N
1/406 (20130101); A61F 2250/0001 (20130101) |
Current International
Class: |
A61F
2/02 (20060101); A61N 1/40 (20060101); A61b
017/36 (); A61n 003/00 () |
Field of
Search: |
;128/1R,1.2,1.3,303.1,303.12,303.17,362,404,410 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Pace; Channing L.
Claims
I claim:
1. In the method of producing a lesion in living brain tissue by
inserting a thermoseed into the tissue in the area where the lesion
is required, and subjecting said thermoseed to an externally
produced radio frequency field, the improvement comprising:
implanting in living brain tissue an electroseed formed of a
metallic alloy having a physiologic Curie point of approximately
238.degree. F. as measured in an albumin standard solution, and
utilizing this implant to produce coagulative lesions in brain
tissue in a temperature range of 110.degree. through 212.degree.
F.
2. As a new article of manufacture, a brain implant for producing
coagulative lesions composed of a metallic alloy, said alloy
comprising at least 18 percent nickel by weight and the balance
selected from the group consisting of chromium, palladium iron and
copper and having a Curie point in air between 250.degree. and
300.degree. F.
3. A brain implant in accordance with claim 2, composed of an alloy
comprising 18 to 24 percent by weight of nickel.
4. An electroseed in accordance with claim 2, composed of an alloy
consisting of approximately 78.7 percent palladium by weight, and
the balance nickel.
Description
This invention relates generally to the known art of radio
frequency thermo-coagulation of human tissue, and more particularly
to improved means and methods of thermo-coagulative
neurosurgery.
BACKGROUND OF THE INVENTION
With the advent of modern neurosurgery, the surgeon has gained
access to the depths of the brain. In the past few decades, a great
effort has been expended in the attempt to find a safe and
effective means for producing controllable subcortical lesions. The
need for this is as great as the spectrum of disease potentially
amendable to such therapy. Such conditions include movement
disorders, of which Parkinson's Disease is an example, intractable
pain, focal epilepsy, various vascular malformations, and certain
cancers, such as those arising from the breast and prostate, where
palliation may be achieved by hypophysectomy.
Many imaginative lesion-producing techniques have been developed,
but so far none has been entirely satisfactory. Most of the systems
developed have necessitated physical connections from an external
energy source to a probe or electrode, which could not remain in
place over a period of time without the risk of infection. The
major disadvantage of other systems, such as proton beam radiation,
focused ultrasonics, lies in their destruction of normal brain
tissue as well as that in the target area.
Induction heating is a well-established industrial method which
permits the rapid and clean through-heating, melting, or precise
surface hardening of metals by an external alternating
electromagnetic field. This field induces currents in the metal
eddy which are opposed by the resistance of the metal, resulting in
the generation of internal heat. A second effect adding to the
dissipation of energy as heat is the induction of hysteresis loops
for the alternation of the magnetic poles within the metal. No
physical contact between the source of electromagnetic energy and
the metal is required.
In the present state of the art, it is known that if a small piece
of appropriate metal is implanted into the brain, and the head then
introduced into an electromagnetic induction field of radio
frequency, the implanted metal can be heated at a frequency and
power level innocuous to the body and brain tissue. In addition, it
is known that the heating can be accomplished in increments over a
period of time, as required to achieve the desired lesion.
A typical utilization of the known art involves the use of an
industrial induction generator operating in the 300-400kc/s range
with a plate power input of up to 23kw is modified for medical
application, to include an elliptical single-turn one-fourth inch
by one-half inch water-cooled copper coil, so that human heads can
be accommodated. The induction coil current flow is approximately
500 amperes. Insulation of the coil is required to prevent radio
frequency burns, and a suitable plastic resin compound is utilized
for this purpose and applied in dip coats.
In the industrial use of induction heating, in which the mass of
metal is large and lies in close approximation to the coil, the
efficiency of the system approximates 60 percent, owing to a
relatively efficient "coupling". In neurosurgical applications, the
efficiency of the system ranges from 0.1 percent to 0.001 percent
because of the small mass of the implant and its distance from the
coil.
When an alternating current is induced in metal, the unique
properties of induction heating apply. One of these properties is
the skin-effect phenomenon where the current flow and heating are
concentrated near the surface of the metal and fall off
exponentially toward the center. This skin-effect is enhanced at
higher frequencies. In a 300-400 kc/s range, an intense, fast, and
localized heat pattern can be produced. This frequency, at the
power level used, is innocuous to living tissue. In the evaluation
of lesions in over 200 experimental animals and 12 human beings,
there has been no observable effect of the RF induction field on
anything other than the implant.
The ideal metallic implant, which can be termed an electroseed,
must be composed of a material that will heat well, but neither
react nor cause reaction in brain tissue, and be of suitable size
and shape for surgical implantation. It is known that some
intracerebral missile fragments tend to migrate through the brain
over a period of time, but in the case of electroseeds, this
behavior does not occur. Unheated electroseeds have been observed
to remain in position after follow-up periods as long as two years.
After the production of a lesion, pathologic examination reveals
that the electroseeds are quite anchored by surrounding
thermo-coagulated protein.
Subcortical implantation is a simple surgical procedure which is
usually performed under local anesthesia through a small twist
drill hole in the skull. A No. 14 gauge needle is guided "freehand"
or by stereotaxis to the target area. The needle stylet extends
beyond the distal end of the needle so that when it is withdrawn, a
tissue defect is created. Needle position is verified by polaroid
X-ray films or by a fluoroscopic image intensification unit. Air
may be injected into the ventricular system to serve as a point of
reference. The electroseed is then dropped into the needle and
extended from the distal end thereof into the preformed tissue
defect.
Following a survey of ferromagnetic metals, iron was found to be
the most readily available material for an electroseed. Carbon
steels have excellent heating properties, but caused too much
tissue reaction. Although this reaction could be alleviated by
coatings of teflon enamel or gold, the possibility remains of
scratching the protective coating during the implantation. Even
alloy steels with a chromium content of over 11 percent (stainless
steels) undergo a typical rusting reaction if the oxide coat is
disturbed or not allowed to form. The most satisfactory material
known in the prior art is type 430 stainless steel having a
chromium content of 17 percent. Heating properties have been
enhanced by pot annealing the steel at a temperature of
1,600.degree. F. with very slow cooling. Because the electroseed is
implanted by extrusion through a needle, it requires a cylindrical
or spherical configuration. Experimentation has indicated that
solid cylinders with length-to-diameter ratios greater than unity
heat more rapidly than spheres, hollow cylinders, or cylinders
composed of rolled foil.
In the determination of electroseed parameters related to maximal
heating in a radio frequency induction field, the fundamental
assumption was made that an electroseed heating in air would bear a
constant relationship to one heating in-vivo. Prior to clinical
experimentation on human beings, electroseeds have been tested in
dummy heads constructed of plastic and filled with gelatin. Heating
of the implanted seeds is accomplished by placing the head within
the RF-induction coil.
It is known that brain neurons are quite heat sensitive, and that
point of contact temperatures over 120.degree. F. destroy the
cells. It is therefore essential to produce lesions at contact
temperatures high enough to destroy the neurons and coagulate
protein, but not so high as to cause liquification of brain tissue.
Unfortunately, it is not possible in the present state of the art
to accurately predict lesion size and shape, although it is
possible to gradually increase the lesion size until the desired
clinical result is obtained. In this fashion, patients with
intractable pain and motion disorders have been successfully
treated.
Several factors influence heat production in the electroseed.
Theoretical calculations indicate that the rate of heat generation
in electroseeds increases with the diameter of the same under all
conditions investigated. The rate of heating increases linearly
with the length of the electroseed in the practical range of from
0.5 to 1.0cm. There is a consistent increase in the rate of heat
generation with increase in magnetic permeability of the metal
comprising the electroseed. The rate of heating may increase or
decrease with an increase in resistivity, depending upon the
combination of other parameters, such as permeability, radius and
frequency. Although one might expect that increasing hysteresis
loop area would increase electroseed heating, it has been found
that following pot annealing with its concomitant decreased
hysteresis loop, heating is enhanced. Hysteresis heating is not as
significant as that due to eddy currents.
Experimental in-air determinations of electroseed heating in regard
to angular orientation of the plane of the coil and radial position
in the coil, have been made. It has been determined that heating
rate is maximum when the long axis of the electroseed is at an
angle of 90.degree. to the plane of the coil, and degrades rapidly
to 0.degree. at which time heat production is nil.
BRIEF DESCRIPTION OF THE PRESENT INVENTION
One of the principal problems encountered in the practice of the
above described therapy is the obtaining of accurate control of the
degree of and extent of the coagulation produced in tissue being
treated. Since the degree of coagulation obtained is a function of
the degree of heat produced by the electroseed, and the amount of
time for which the heat is transmitted to the area to be
coagulated, it is apparent that the electroseed ideally should be
capable of maintaining a reasonably fixed temperature over a
substantial period of time, once it has been initially heated from
body temperature. Where this is not the case, the heat produced by
the electroseed over a given period of time is not only a function
of the radio frequency energy supplied and the amount of time over
which the energy is supplied, but also a function of how long the
seed is heated for a given exposure.
Type 430 stainless steel has been the material used in the past,
being the most satisfactory material known. However, it continues
to heat with increased power to approximately 2,000.degree. F. in
air. The ideal temperature for producing coagulation varies between
150.degree. to 200.degree. F. Since the degree of "coupling"
between the radio frequency generator and the thermoseed is less
than 1 percent, it will be readily appreciated that controlling the
heat of the thermoseed by regulating power supplied by the radio
frequency generator is extremely difficult to do in practice.
It is, therefore, among the principal objects of the present
invention to provide a thermoseed which will heat only to the
desired range in a surplus of radio frequency energy supplied.
Another object of the invention lies in the provision of an
improved thermoseed of the class described which will possess all
of the advantages of known stainless steel thermoseeds, and which
may be fabricated using known techniques.
A further object of the invention lies in the provision of an
improved thermoseed of the class described formed from alloys
having a predetermined Curie point within the desired range for
effecting coagulation.
In the drawings,
FIG. 1 is a graph showing the heating with time of electroseeds
formed from various alloys in air in the presence of excess radio
frequency power.
FIG. 2 is a graph showing the heating of type 430 stainless steel
in albumin.
FIG. 3 is a similar graph showing the heating of type 430 stainless
steel in rat cortex.
FIG. 4 is a similar graph showing the heating of type 430 stainless
steel in cat cortex with normal blood flow.
FIG. 5 is a graph showing the heating of a palladium nickel alloy
in albumin.
FIG. 6 is a similar graph showing the heating of the same alloy in
rat cortex with no blood flow.
FIG. 7 is a similar graph showing the same palladium-nickel alloy
heated in cat cortex with normal blood flow.
FIG. 8 is a similar graph showing the heating of a copper nickel
alloy in albumin.
FIG. 9 is a similar graph showing the heating of a nickel-chromium
alloy in albumin.
FIG. 10 is a similar graph showing the heating of a nickel-iron
alloy in albumin.
FIG. 11 is a similar graph showing a slightly different nickel-iron
alloy heated in albumin.
Referring to FIG. 1 in the drawing, it will be understood that the
illustrated examples are for purposes of illustration only, and not
to be construed as limiting with respect to the extent of the
present invention. It will be observed that when heated in air, the
Curie points of each alloy are reached within a range of 60 to 200
seconds after the supply of power is initiated, and in each case is
above 300.degree. F., or far in excess of the desired operative
temperature of 150.degree. to 200.degree. F. Although the initial
rise in temperature is relatively rapid, it will be apparent from a
consideration of the graph that the total amount of heat
transmitted for purposes of coagulation is much less during the
first 20 seconds than during the second 20 seconds in each case.
Excess operating temperature is reached in each case within the
first 20 seconds. The highest temperature reached is 400.degree.
F., with the copper-nickel alloy.
This performance can be contrasted with the showings in FIGS. 2 to
4 in the drawings. Type 430 stainless steel, the most widely used
of the known materials in the art, heats almost instantaneously to
800.degree. F., and within a minute reaches 1,500.degree. in
albumin, a protein material. Using the same material in rat cortex
and cat cortex, heats as high as 1,900.degree. are obtained within
3 minutes.
FIG. 5 illustrates a similar experiment substituting a thermoseed
formed of an alloy consisting of by weight 78.7 percent palladium,
and the remainder nickel. When immersed in albumin, the Curie
temperature of approximately 230.degree. F. is reached in 20
seconds, and the temperature remains substantially constant
thereafter, until 2 minutes has elapsed.
In FIG. 6, placing a thermoseed of this alloy in rat cortex with no
blood flow, results in a substantially constant Curie temperature
of 206.degree. F., a very usable value.
As seen in FIG. 7, in cat cortex, with normal blood flow, a still
more usable value of 203.degree. F. is obtained.
FIG. 8 illustrates the heating of a copper-nickel alloy thermoseed,
the copper forming 25.8 percent by weight of the alloy. It will be
observed that heating in this case to the Curie point requires 3
minutes, and a maximum of approximately 290.degree. is reached at
that point. However, because of the lack of flatness in the heating
curve, this alloy is less desirable than other alloys described
herein.
FIG. 9 illustrates a nickel-chromium alloy, in which nickel
comprises 93.75 percent by weight of the alloy. Here, the albumin
test reveals that the thermocoagulation temperature is reached
after approximately 1 minute, and the temperature continues to rise
relatively slowly thereafter until approximately 10 minutes, at
which point the temperature exhibits a marked drop.
FIG. 10 illustrates a nickel-iron alloy, nickel comprising 31.12
percent by weight of the alloy. Coagulation temperature is reached
in approximately 30 seconds, and maximum temperature is
approximately 300.degree., again in albumin, a sharp drop again
being exhibited after 5 minutes.
FIG. 11 illustrates a slightly modified nickel-iron alloy, in which
the nickel comprises 31.08 percent by weight. Here
thermocoagulation temperature in albumin is reached almost
instantaneously, and maximum temperature of approximately
330.degree. is reached after 9 minutes. However, the rise in
temperature is erratic, exhibiting heat loss between 3 and 4
minutes, and between 6 and 8 minutes over somewhat similar
patterns.
In the determination of electroseed parameters, related to maximal
heating in an RF-induction field, the fundamental assumption was
made that a given electroseed heating in air would bear a constant
relationship to one heating in-vivo. Early comparative in-air
testing was performed using a simple alcohol thermometer to record
temperature. The more precise determinations of variation in
heating in albumin and rat and cat cortex were performed using a 35
gauge spirally wound copper-constantan thermocouple connected to a
grass model 5 polygraph with a Model 5 P5C dc preamplifier. The
thermocouple itself was not heated by the RF field. Prior to
clinical experimentation on human beings, electroseeds were tested
in dummy heads constructed of plastic and filled with gelatin.
Thus, the pattern of heating of the alloys illustrated in FIGS. 8
through 11, inclusive, may be reasonably expected to be duplicated
at substantially lower temperatures in cortex, with reasonable
utility from the standpoint of obtaining relatively flat portions
of curves in the desired thermocoagulation temperature range. With
the temperature of the thermoseed maintained at a useable level,
the control of the formation of the lesion is more closely
regulated to the exposure time within the RF field, a value which
can be simply determined by stop-watch, and controlled by
interrupting the flow of current to the RF generator. Operating in
this manner, the RF generator may be allowed to supply an excess of
power to the thermoseed, and the presumption is made that the
thermoseed will very quickly be operating at its Curie point.
For practical and convenient testing, I have found that operating
the thermoseed in albumin maintained at 30.degree. C.
(78.75.degree. F.), a very close approximation can be made of its
behavior in brain cortex with normal blood flow. This may be
conveniently done by immersing a basin containing the albumin in a
temperature controlled bath. Comparing FIGS. 5, 6 and 7 in the
drawing, using a palladium-nickel alloy, it will be observed that
the Curie point in albumin is approximately 238.degree. F. The
Curie point in rat cortex with no blood flow is 206.degree. F., and
in cat cortex with normal blood flow is 203.degree. F. Thus, the
actual difference is approximately 30.degree. F., which can be
taken into account insofar as the predicted Curie temperature in
brain cortex with normal blood flow is concerned. This relationship
has been firmly established in multiple experiments and designates
the albumin standard as a basis for accurate determination of
thermoseed heating in brain tissue.
I wish it to be understood that I do not consider the invention
limited to the precise details shown and set forth in this
specification, for obvious modifications will occur to those
skilled in the art to which the invention pertains.
* * * * *