U.S. patent number 3,653,380 [Application Number 05/011,555] was granted by the patent office on 1972-04-04 for aerosol powder dosage dispensing device.
This patent grant is currently assigned to American Cyanamid Company. Invention is credited to Lloyd Frank Hansen.
United States Patent |
3,653,380 |
Hansen |
April 4, 1972 |
AEROSOL POWDER DOSAGE DISPENSING DEVICE
Abstract
A dispensing device is described with a mixing chamber in which
a dose of powder or other medicament is introduced through an
outlet for a human body cavity, such as a mouthpiece or a hollow
projection suitable for inserting in a nostril. A source of gas
under pressure, for example from an aerosol can, is introduced into
the chamber at an angle, and there is present in the chamber a
larger movable element, such as a steel ball, which vibrates and
breaks up the particles or aggregates. In one modification a half
capsule containing the dosage may be introduced into the chamber
and the capsule after emptying itself constitutes the moving
element.
Inventors: |
Hansen; Lloyd Frank (Campbell
Hall, NY) |
Assignee: |
American Cyanamid Company
(Stamford, CT)
|
Family
ID: |
21750906 |
Appl.
No.: |
05/011,555 |
Filed: |
February 16, 1970 |
Current U.S.
Class: |
128/203.15 |
Current CPC
Class: |
A61M
13/00 (20130101); A61M 15/0031 (20140204); A61M
15/00 (20130101); A61M 15/0028 (20130101); A61M
15/0008 (20140204); A61M 2205/8225 (20130101); A61M
2202/064 (20130101) |
Current International
Class: |
A61M
13/00 (20060101); A61M 15/00 (20060101); A61m
013/00 (); A61m 011/00 (); A61l 013/00 () |
Field of
Search: |
;128/265,266,201,203,206
;239/142,143,DIG.5,307 ;222/193 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Gaudet; Richard A.
Assistant Examiner: McGowan; J. C.
Claims
I claim:
1. A dispenser for dispensing single doses of finely divided
powdered medicament for oral use, comprising
a mouthpiece and an integral housing, a converging funnel-shaped
entrance in the housing leading to the mouthpiece,
a conical screen element fitting into said entrance,
a plug with a conical end introducible into the housing from the
end opposite the mouthpiece and provided with sealing means,
whereby a medicament chamber of predetermined size is formed by
introducing the plug a predetermined distance into said
housing,
at least one movable ball in the medicament chamber, which ball
vibrates or spins when gas pressure is introduced, whereby
turbulence results,
pressure means for introducing gas into the chamber at an angle to
the chamber,
and an extension on the housing at right angles to the mouthpiece
axis and shaped to receive gas from said pressure means, which
extension and housing is provided with a plurality of conduits to
the medicament chamber, one of larger cross-section than the
others, the conduits being positioned so that gas flowing through
them produces streams which contact each other in the chamber.
2. A dispensing device according to claim 1 in which one of the
conduits is of greater cross-section than the other so that a
larger volume of gas through the larger is struck by a smaller
volume of gas through the smaller opening, thereby agitating said
ball and inducing high turbulence, and both conduits are about
tangential to the housing.
Description
BACKGROUND OF THE INVENTION
A number of medicaments are introduced either orally or nasally.
For instance, there are a number of nasal inhalators and there are
also some devices for introducing finely divided medicament into
the oral cavity and thence on into the respiratory system. In the
past there were two general types. The nasal inhalator had a
medicament chamber, openings to the atmosphere, and of course a
projecting hollow member which was introduced into the nostril. On
inhaling, air was sucked into the chamber, picked up medicament,
which in some cases was liquid and other cases was sublimed from
crystals. The type of dispenser for introducing finely divided
medicament into the oral cavity not only had a different shaped
mouthpiece but usually had a container feeding into a venturi tube
through which air or a gas flowed, picking up the medicament.
Where there was no reason to measure the dose accurately, these
types of dispensers were quite satisfactory and are used on a large
scale, particularly the nasal inhalators. However, for many
purposes it is desireable to introduce a definitely measured dose,
and this was difficult or impossible with the devices which were
used in the past. It is with improved dispensing devices which can
dispense accurately measured doses that the present invention
deals.
SUMMARY OF THE INVENTION
The present invention departs from prior designs in several
important respects. First, there is a medicament chamber into which
gas or air under pressure is introduced at an angle to create
turbulence so that all of the dosage introduced into the chamber is
carried on into the human body cavity, e.g., nose or mouth, and
thence on into the respiratory system.
Another important feature of the present invention is that in the
medicament chamber there is present a loose element, such as a
steel ball or, in another modification, half of the shell of a
capsule carrying a dosage of medicament. These movable elements
vibrate, collide with the medicament being atomized, and prevent
formation of or break up any coarser materials such as coarser
aggregates of a powdered medicament. Also, adhering of medicament
to the walls of the dispensing chamber is greatly reduced and for
the most part completely eliminated.
The present invention, therefore, permits discharging a finely
divided spray of liquids of solid particles from an accurately
predetermined dosage either into the nose or mouth or similar body
cavity. No problem of over dosage is presented, which was a problem
with the dispensers used in the past; and so even with medicaments
which in excessive amounts have undesirable effects, complete
safety is assured.
In general, the principles of the present invention can be
incorporated into two somewhat different shaped devices. In one
device, which is particularly usable with finely divided solid
medicaments for oral use, a chamber is formed with a plug and
sealer and a funnel-shaped entrance to a mouthpiece. Preferably a
conical screen is also provided further to assure that larger
aggregates are not dispensed. Gas under pressure is then introduced
into the chamber substantially at right angles. High turbulence
results, and if there is present a steel ball or other element
which can vibrate and move, thorough and complete breaking up of
aggregates results and the exactly predetermined dose is introduced
in the best form. In a preferred modification of this type of
dispenser, the gas under pressure is introduced through two
openings which direct a large volume of lower velocity gas directly
into the chamber and a smaller volume of higher velocity gas into
another part of the chamber to increase the turbulence.
The second general type of dispenser of the present invention at
first glance appears somewhat similar to a nasal inhalator.
However, the air passages are sealed up and a tube or conduit
carries gas under pressure into a side of the mixing chamber. As
the gas comes in at an angle, there is high turbulence and a very
thorough distribution of the medicament results. The medicament is
ordinarily introduced in a half of a capsule, the capsule half
vibrating violently, which results in complete emptying of
medicament dose and also breaks up larger aggregates.
In the second type of dispenser referred to above, ordinarily the
conduit enters at an angle which is not quite a right angle,
whereas in the first type described above the gas is usually
introduced at right angles to the flow through the mouthpiece. The
particular angle is not critical so long as it is a sufficient
angle to produce a high degree of turbulence. While it is
theoretically possible to introduce liquids or suspensions in
either type of dispenser, a liquid is much more readily introduced
in the second type, so that the first type is primarily effective
for medicament in the form of finely divided solids, although the
invention is not strictly limited thereto and even in this type it
is possible to introduce liquids although less readily than in the
second type.
Reference has been made to introducing the medicament into the
respiratory system. This is the most important field for the
present invention, but it is possible to introduce small doses of
medicament into the nasal passages in the second type of dispenser
without their being driven into the lungs. Also, while the nose and
mouth are the cavities in which the dispensers of the present
invention are primarily used, other bodily cavities can also
receive accurately predetermined dosages of finely divided
medicament; and therefore, in its broader aspects the present
invention is not strictly limited to dispensers to be used in oral
or nasal use.
The nature of the gas under pressure actually forms no part of the
present invention. However, it is desirable to form the gas
introducing tube to the mixing chamber so that it can be pressed on
the discharge valve of an ordinary aerosol container which contains
a volatile liquid or gas, such as Freon, of suitable boiling point.
This permits a very compact and readily portable package and may be
considered as the preferred form of use of the invention. It should
be understood that when the dispenser is pressed onto the discharge
valve of an aerosol can it should be pressed for a short but still
sufficient time to assure that the full dosage of medicament in the
dispensing chamber is ejected into the desired body cavity. This
presents no problem as an exact time measurement is not needed.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a cross-section through a dispensing chamber for oral
use;
FIGS. 2, 3 and 4 show separate elements of the dispenser, FIG. 4
being an exploded view of all of the elements;
FIG. 5 shows the elements of FIG. 4 assembled and connection to an
aerosol container;
FIG. 6 is a cross-section through a nasal inhalator of the prior
art, and
FIG. 7 is a similar cross-section through a nasal inhalator of the
present invention.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
FIGS. 1 to 5 relate to a dispenser for oral use. The dispenser has
a housing 1 forming part of a medicament chamber, with a mouthpiece
2 and a funnel-shaped inlet 3 to the mouthpiece in the housing 1. A
chamber is formed by a plug 5 with a conical end and a sealing
O-ring 7. There is also provided a conical screen 4, which can be
seen in the exploded view in FIG. 4 and in the assembled view in
FIG. 5.
The chamber is assembled by first introducing the conical screen 4,
which is slightly larger at its base than the internal diameter of
the housing 1. This conical screen is introduced with its apex into
the throat of the mouthpiece 2, as can be seen best in FIG. 5. A
steel ball 6 is then introduced and the plug 5 inserted to a depth
to produce a chamber of the desired dimensions. Chambers of various
dimensions can be produced with the same equipment by varying the
distance that the plug 5 is inserted into the housing 1. It will be
seen that the dispensing chamber is between the conical end of the
plug 5 and the screen 4.
In use a dose of medicament, for example finely powdered
medicament, is introduced through the mouthpiece, the housing 1
being held so that the mouthpiece points up. The finely divided
medicament passes through the screen 4 and, if necessary, some
tapping of the instrument may be used in order to be sure that all
of the medicament enters the chamber. Then an extension 8 on the
housing 1 with a central conduit 9 is pushed onto the valve
mechanism 10 of a conventional aerosol container, as is shown in
FIG. 5. This container is of somewhat simplified design as it is
not required that it contain material to be sprayed.
When pressed down on the valve, the Freon gas in the container
flows into the chamber through two openings, which can be seen in
the cross-section view of FIG. 1. Opening 12 is the larger one and
opening 13 is the smaller one. Most of the Freon enters through the
larger opening 12 and because of the size of the opening has
relatively low velocity. A smaller portion at much higher velocity
enters through the opening 13 and the two streams of gas strike
each other and further enhance the turbulence. The steel ball 6
vibrates and bounces around, which assures further fineness of
subdivision and also breaks up any larger aggregates of the powder
so that everything is blown out through the screen 4 and the
mouthpiece 2 and the whole of the predetermined dosage is
introduced. A single steel ball 6 is shown, but, of course, more
than one may be present and they may be made of other
materials.
FIGS. 6 and 7 show nasal inhalators. In FIG. 6 the inhalator 14,
with a hollow extension 15 which goes into the nostril,
communicates with a medicament chamber 16. The element 15 is
screwed onto a boss on the inhalator 14 or can be a friction fit in
the conventional manner. When the inhalator is introduced into a
nostril and the patient inhales, air flows in through the tubes 17
and a portion of the medicament in the chamber 16 is introduced
into the nostril. This type of inhalator is very satisfactory where
an accurately predetermined dose is not needed and can be used many
times where materials such as sublimable anticongestants are
present. However, exact predetermined dosage cannot be
provided.
FIG. 7 shows the present invention, in which the openings 17 are
completely eliminated and a tube 19, which at its other end
attaches to the valve of the aerosol can enters into the chamber 16
at a right angle. In use the nasal portion 15 is removed by
unscrewing at 18, or removing it when it is a friction fit, and a
half capsule 20 is introduced into the medicament chamber. The
inhalator element 15 is then fastened on by screwing or by friction
fit and the tube 19 is brought into contact with the valve 10 of an
aerosol can, as is shown for the other form of dispenser in FIG. 5.
The blast of Freon enters at an angle, causes high turbulence in
the chamber 15, which is further advanced by the vibration and
spinning of the half capsule 20, resulting in complete emptying
thereof and in further turbulence, so that the whole dose is
introduced into the nostril.
While in the type shown in FIGS. 1 to 5 it is usually preferable to
introduce the exact dosage through the mouthpiece, it is, of
course, possible to remove the plug 5 and introduce a half capsule
as in FIG. 7 into the chamber, replacing the plug and proceeding
then as has been described above in connection with FIGS. 1 to
5.
* * * * *