U.S. patent number 3,650,276 [Application Number 04/810,167] was granted by the patent office on 1972-03-21 for method and apparatus, including a flexible electrode, for the electric neurostimulation of the neurogenic bladder.
This patent grant is currently assigned to Institutul DeMedicina Si Farmacie. Invention is credited to Theodor Burghele, Mihai Demetrescw, Vasile Ichim.
United States Patent |
3,650,276 |
Burghele , et al. |
March 21, 1972 |
**Please see images for:
( Certificate of Correction ) ** |
METHOD AND APPARATUS, INCLUDING A FLEXIBLE ELECTRODE, FOR THE
ELECTRIC NEUROSTIMULATION OF THE NEUROGENIC BLADDER
Abstract
A method for artificial voiding of the bladder involves the
introduction of electrodes onto the motor nerves of the bladder,
and placing on the anterior wall of the sacrum a receiver means for
producing an electric current within such electrodes when excited
by an electromagnetic field, and periodically applying an electric
and an electromagnetic field from the exterior of the body to said
receiver means to induce voiding of the bladder.
Inventors: |
Burghele; Theodor (Bucharest,
RU), Ichim; Vasile (Bucharest, RU),
Demetrescw; Mihai (Bucharest, RU) |
Assignee: |
Institutul DeMedicina Si
Farmacie (Bucharest, RU)
|
Family
ID: |
5729398 |
Appl.
No.: |
04/810,167 |
Filed: |
March 25, 1969 |
Current U.S.
Class: |
607/27; 607/40;
607/61; 607/72 |
Current CPC
Class: |
A61N
1/36007 (20130101); A61F 2/0036 (20130101); A61N
1/05 (20130101); A61N 1/3787 (20130101); A61N
1/0551 (20130101) |
Current International
Class: |
A61F
2/00 (20060101); A61N 1/375 (20060101); A61N
1/36 (20060101); A61N 1/378 (20060101); A61N
1/05 (20060101); A61N 1/372 (20060101); A61n
001/36 () |
Field of
Search: |
;128/418,419,421,422 |
References Cited
[Referenced By]
U.S. Patent Documents
|
|
|
3421511 |
January 1969 |
Schwartz et al. |
|
Other References
Burghele et al., Rumanian Medical Review, Vol. 3, No. 1 1959, pp.
48-51.
|
Primary Examiner: Kamm; William E.
Claims
We claim:
1. A method for artificial voiding of the bladder comprising
(a) surgically introducing electrodes onto the motor nerves for the
bladder, (b) surgically placing on the anterior wall of the sacrum
receiver means for the producing of an electric current in the
electrodes when excited by an electromagnetic field and attaching
said receiver means to the electrode to apply the current thereto,
(c) generating an electromagnetic field, and (d) periodically
applying the electromagnetic field to the receiver means to excite
the same and induce voiding of the bladder.
2. The method of claim 1 wherein in said step of attaching,
electric current is applied to said electrodes in rectangular
pulses of 5 to 10 milliamperes lasting for up to approximately 7
milliseconds at a rate of approximately 15 - 20 pulses per
second.
3. The method of claim 2 wherein in said step of applying, the
electromagnetic field is applied at a frequency of 300 kHz. and of
an intensity to penetrate the body to a depth of approximately 15
cm.
4. The method of claim 3, wherein the step of introducing
electrodes includes the step of folding over a bladder motor nerve
the foil of an electrode having two platinum wires attached to a
foil of insulating material tolerated by the body and covered with
a similar insulating foil on two ends of each wire to leave a
central area of each wire uncovered, the foil being folded over the
nerve to bring the uncovered region of the wires into contact with
the nerve.
5. An electrode for applying electrical stimulation to nerves,
comprising, in combination:
a. a foil of flexible insulating material tolerated by the human
body,
b. a pair of wires attached to one surface of said foil,
c. a first piece of similar insulating material attached to the
foil to cover the two wires at one end of the foil, and
d. a second piece of insulating material attached to the other end
of the foil to cover the two wires at the other end of the foil and
leave the central region of both wires uncovered.
6. The combination defined in claim 5 in which said insulating
material is polyethylene.
7. The combination defined in claim 6 in which said wires are
platinum.
8. Apparatus for inducing artificial voiding of the bladder
comprising, in combination:
a. means for emitting outside of a human body an electromagnetic
field having a high power of penetration into the human body, and
having an oscillator supplying oscillations with a frequency of 300
kHz., a generator producing rectangular impulses in the range of 5
to 10 milliamperes, at a frequency in the range of 15 to 20 Hz.,
and having a duration of 7 milliseconds, modulator means for
modulating the signal supplied by said oscillator as a function of
the rectangular impulses produced by said generator, a power
amplifier that receives and amplifies a signal from said modulator,
and inductor which receives a signal from said modulator, and
antenna means inductively coupled to said inductor for producing
the electromagnetic field;
b. A pair of electrical wires of a material tolerated by the human
body;
c. Receiver means for producing an electric current when stimulated
by electromagnetic radiation, and being of a size to fit between
the sacrum and the bladder of a human body and adapted to be
mounted on the anterior wall of the sacrum, and being covered with
a material tolerated by the human body, said resonant circuit
having a coil with a tap; a first capacitor connected across said
coil, detector means connected to the tap of said coil and to one
of said electrical wires, the other of said electrical wires being
connected to said coil and a second capacitor connected between
said electrical wires to form a filter circuit; and
d. electrodes mounted on said wires and adapted to be attached to
pelvic nerves for applying electrical stimulation to the nerves,
each electrode comprising, in combination:
i. a foil of flexible insulating material tolerated by the human
body,
ii. a pair of wires attached to one surface of said foil,
iii. a first piece of similar insulating material attached to the
foil to cover the two wires at one end of the foil, and
iv. a second piece of insulating material attached to the other end
of the foil to cover the two wires at the other end of the foil and
leave the central region of both wires uncovered.
9. The combination defined in claim 8 in which said detector means
has a germanium diode.
10. The combination defined in claim 8 in which said receiver means
is covered with polyethylene and said electric wires are made of
platinum material.
Description
The invention relates to a method and an apparatus for the electric
neurostimulation from a distance of the neurogenic bladder
following spinal cord injuries as well as other affections of the
nervous system.
Several methods of treatment of urine retention as a consequence of
spinal cord injuries and of other affections of the nervous system
are known:
A. The intermittent catheter drainage which, on one side presents
the disadvantage of urinary tract infection with all its
complications ( calculosis, pyelonephritis, uremia) and on the
other side the impossibility of being applied in all cases (
urethral strictures, rupture of the urethra, and so on).
B. The permanent catheter drainage, which represents a yet greater
danger of infection, compromising of the muscular and elastic
tissue of the bladder, uremia, etc.
C. Cystostomy, nearly abandoned, which besides the danger of
infection delays the recovering of the bladder reflex and creates a
great inconvenience for the patient.
D. Another direct electric stimulation of the bladder muscle is
known, which consists in its stimulation with electrodes of
stainless steel wires or disks fixed on the bladder wall,
electrodes which are bound to a receiver surgically applied under
the skin, and started by an external transmitter with small power
of penetrability.
On account of the high electromotor tension induced, up to 40
volts, this method presents the disadvantage of producing pain
during the stimulation, contractions of the lower extremities and
abdomen muscles, burns and scars at the stimulation site as well as
perforations of the bladder wall, the interruption of the
conductors by motion, all drawbacks that counterindicate or limit
the possibility of applying this method.
The method, according to the invention, eliminates the above
mentioned disadvantages in that, in order to avoid the catheter
drainage, infections, complications and the drawbacks resulting
from the application of electric stimuli, on the bladder muscle,
the electric stimulation of the bladder motor nerves in man is
applied, by using a receiver surgically introduced onto the
anterior wall of the sacrum, provided with two bipolar electrodes,
one for each pelvic nerve, the electrodes being fixed on these
nerves, which receive from the receiver rectangular stimuli having
variable parameters, comprised between 5 and 10 ma., an
electromotor tension of about 2.5 volts, a frequency of 15 - 20
impulses and a stimulus duration up to 7 ms., the stimulus being
introduced into the receiver by an electromagnetic field, produced
by the antenna of an external transmitter.
The apparatus according to the above method consists of an external
inductor, the antenna of which produces an electromagnetic field
with great power of penetrability into the body and which exerts an
influence on a receiver previously placed onto the anterior wall of
the sacrum, composed of an oscillating circuit accorded with the
frequency of the external inductor, the secondary circuit of which
in feeding a detector ( a germanium diode) the current being
filtered by means of a capacitor and applied at the electrode
terminals, electrodes which are wrapped around the nerves.
The application of the invention is illustrated in the following
example in relation to FIGS. 1,2,3,4 and 5, which represent:
FIG. 1 is a schematic block diagram of apparatus according to the
present invention.
FIG. 2 is a schematic diagram showing in greater detail the
inductor and receiver of FIG. 1.
FIG. 3 is a detail of the position of the receiver and electrodes
in the body.
FIG. 4 is a schematic detail of the electrodes and of their
position on the pelvic nerves.
FIG. 5 is a detail of folding of the electrode on the pelvic
nerves.
According to the invention, the apparatus emitting electromagnetic
waves, is composed of a generator G (FIG. 1), which produces
rectangular impulses with the following characteristic: 5 - 10 ma.,
15 impulses per second, and a duration of 7 ms.
The generator G, by means of a modulator M, modulates an electric
current with a frequency of 300 kHz., oscillations supplied by an
oscillator O. Having been amplified by the amplifier P, the
electric current reaches an inductor I, the resonant circuit of
which produces by means of an exterior antenna A (FIG. 2), an
electromagnetic field H with great power of penetrability into the
body.
The electromagnetic field H exerts an influence on a receiver R,
previously fixed on the anterior wall of the sacrum, composed of an
resonant circuit LC.sub.1 (FIG. 2), accorded with the frequency of
the exterior inductor, the secondary circuit of which feeds a
detector D (germanium diode), the current being then filtered by
means of a capacitor C.sub.2 and applied at the electrode terminals
E.
The application of the method consists in:
dissection of the pelvic nerves (1) (FIGS. 4 and 5), on which are
applied the bipolar electrodes (2), composed of two foils (3) and
(4) (FIGS. 4 and 5), made of plastics, for instance polyethylene,
the external foil (3) being continuous and the interior one (4)
being interrupted in the central zone for an adequate distance, two
platinum wires (5) being introduced between the foils, so that by
folding (FIG. 5) an intimate contact with the pelvic nerves surface
(1) is obtained, in this way the electrode being sewed in two
points.
The receiver R (FIG. 3) is located on the anterior wall of the
sacrum S, retroperitoneally, the pelvic nerves (1) receiving
electric stimuli from the electrodes (2) during all the period of
time in which the antenna is situated parallel to the receiver and
in the area where the receiver is included.
These stimuli, transmitted to the pelvic nerves (1), produce the
contraction and voiding of the bladder V (FIG. 3).
Some clinical cases are reported further, in which the electric
neurostimulation of the pelvic nerves, according to the invention,
was applied in cases of spinal cord injuries.
Case 1. Patient with accidental fracture of the spine at the level
of the X.sup.th and XI.sup.th thoracic vertebrae. Because of
paraplegia with urine retention, drainage with catheter indwelling
is carried on. After 3 weeks from the accident, the receiver for
the neurostimulation of the bladder is surgically applied, the
catheter being taken off.
The artificial voiding of the bladder by neurostimulation is
performed; the bladder voids without residue and the urine is
sterile on culture.
Case 2. Spinal cord injury with fracture at the level of VIIIth
thoracic vertebra. Catheter drainage of the bladder is first and
subsequent urinary infection results. After 4 weeks, at the
withdrawing of the catheter, the urine retention persists.
The artificial voiding of the bladder by electric neurostimulation
is performed. The urine becomes clear and sterile. After 2 months,
good results are obtained by voiding with neurostimulation.
Case 3. Urinary infection is present due to permanent catheter
drainage in a patient with spinal cord injury and spinal cord
section at the level of the VIth thoracic vertebra.
Receiver and neurostimulation, with complete bladder voiding are
applied, the clearing and sterilization of the urine being
obtained.
The contraction of the paralyzed bladder as a result of spinal cord
injuries or other affections of the nervous system is performed,
according to the invention, by electric stimulation with a
receiver, insulated with polyethylene, surgically introduced into
the body and connected with bipolar electrodes which are placed on
the pelvic nerves of the bladder.
The receiver is put in action, sending electric stimuli to the
pelvic nerves, at the moment when the antenna of an external
transmitting apparatus is brought nearer to the zone where the
receiver is included.
The voiding of the bladder by electric stimulation of its motor
nerves allows the avoiding of the catheter drainage which presents
the danger of urinary tract infection with all its subsequent
complications.
It will be understood that the above description of the present
invention is susceptible to various modifications, changes and
adaptations, and the same are intended to be comprehended within
the meaning and range of equivalents of the appended claims.
* * * * *