U.S. patent number 3,634,924 [Application Number 05/029,889] was granted by the patent office on 1972-01-18 for method of making multilumen balloon catheter.
This patent grant is currently assigned to American Hospital Supply Corporation. Invention is credited to Bruce D. Bett, Lawrence W. Blake, Clement E. Lieber.
United States Patent |
3,634,924 |
Blake , et al. |
January 18, 1972 |
METHOD OF MAKING MULTILUMEN BALLOON CATHETER
Abstract
A multilumen tube is extruded from a thermoplastic material
having a memory characteristic. An end portion of the tube is
heated sufficiently to soften the plastic and permit the end
portion to be drawn out to a reduced diameter. A pair of metal
ferrules is placed on the reduced end portion in predetermined
positions spaced a short distance apart. Then the reduced portion
is heated in relaxed condition causing it to reexpand and lock the
ferrules in place. Balloon inflation openings are formed
communicating with one of the lumens. A sleeve of balloon material
is secured by bindings over the ferrules. In one embodiment the
tube is limp and the balloon is utilized as a sail to flow carry
the catheter through a vein into and through the heart and into the
pulmonary artery.
Inventors: |
Blake; Lawrence W. (Huntington
Beach, CA), Bett; Bruce D. (Dana Point, CA), Lieber;
Clement E. (Yorba Linda, CA) |
Assignee: |
American Hospital Supply
Corporation (Evanston, IL)
|
Family
ID: |
21851418 |
Appl.
No.: |
05/029,889 |
Filed: |
April 20, 1970 |
Current U.S.
Class: |
29/447; 264/230;
604/103 |
Current CPC
Class: |
A61M
25/1034 (20130101); Y10T 29/49865 (20150115); A61M
2025/1065 (20130101) |
Current International
Class: |
A61M
25/00 (20060101); B23p 011/02 () |
Field of
Search: |
;29/447,157 ;264/230
;128/348,349B |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Moon; Charlie T.
Claims
Having now described our invention and in what manner the same may
be used, what we claim as new and desire to protect by Letters
Patent is:
1. The method of making a balloon catheter comprising providing a
catheter tube of a thermoplastic material having a memory
characteristic and containing a balloon inflation lumen, applying
heat to an end portion of said tube sufficient to soften said
material, drawing out and elongating said softened portion to
shrink its diameter, applying a pair of rigid ferrules over said
shrunken portion, applying heat to said shrunken portion to
reexpand its diameter and lock said ferrules on said tube, forming
a balloon inflation opening in said material communicating with
said lumen, applying a sleeve of elastic balloon material over said
reexpanded portion, and binding said balloon material to said
ferrules.
2. The method of claim 1 including the step of forming said tube
initially by extrusion.
3. The method of claim 1 including the step of applying a rotary
cutter to said tube to form said balloon inflation opening.
4. The method of claim 1 wherein said tube has a through flow lumen
in addition to said balloon inflation lumen.
5. The method of claim 1 including the step of plugging the distal
end of said balloon inflation lumen.
6. The method of claim 5 including the step of die-forming a
contoured tip on said tube.
7. The method of claim 1 wherein said softening heat is applied by
hot water.
8. The method of claim 1 wherein said reexpanding heat is applied
by radiant energy.
Description
BACKGROUND OF THE INVENTION
This invention relates to multilumen balloon catheters and is
particularly concerned with a new and improved method for making
such catheters and with an improved flow-directed catheter.
In catheters which are very small in diameter the balloon cannot be
formed by a dipping process as are the balloons on the larger
drainage catheters. The most satisfactory balloon construction has
proved to be a very thin elastic sleeve secured at its ends to the
catheter tube by windings of fine thread. There is a tendency,
however for the plastic in the thin wall sections of a small tube
to yield and creep under the pressure of the windings, choking off
the lumens in the tube. This makes it difficult to construct a
multilumen catheter of small enough size to pass freely through
small arteries and veins and especially when the catheter tube is
soft and limp as in the case of a flow-directed catheter.
Objects of the invention are, therefore, to provide an improved
multilumen balloon catheter, to provide an improved and economical
method for making such a catheter, to provide improved flow
capacity in small multilumen catheters, to provide an improved
support for the balloon windings, and to provide an improved
flow-directed catheter.
SUMMARY OF THE INVENTION
In the present construction, multilumen catheter tubes are
economically produced by extrusion of a thermoplastic material
having a memory characteristic. The novel process steps comprise
heating an end portion of the tube sufficiently to permit drawing
out said portion of the tube to reduced diameter, applying a pair
of metal ferrules over the reduced diameter portion of the tube,
heating said end portion of the tube sufficiently to reexpand the
tube and lock the metal ferrules in place, applying an elastic
sleeve-type of balloon and binding end portions of the balloon over
the metal ferrules.
The plastic material under the ferrules is thus not subject to the
binding pressure and does not yield or creep causing constriction
of the lumens. Catheters of very small size may be made in this
manner and the method is of particular advantage in making
flow-directed catheters having a soft and limp tube.
The invention will be better understood and additional objects and
advantages will become apparent from the following description of
the preferred embodiments illustrated in the accompanying drawings.
Various changes may be made, however, in the details of
construction and arrangement of parts and in the details of the
method and all such modifications within the scope of the appended
claims are included in the invention. The present catheters are not
limited to use in veins and arteries but may also be used in the
biliary system and elsewhere as will be understood by persons
skilled in the art.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a schematic illustration of the first step in the method
of the invention;
FIG. 2 illustrates a second step;
FIG. 3 illustrates a third step;
FIG. 4 illustrates a fourth step;
FIG. 5 illustrates the final step;
FIG. 6 is a longitudinal sectional view of the completed catheter
tip;
FIG. 7 is a view on the line 7--7 in FIG. 6;
FIG. 8 is a view on the line 8--8 in FIG. 6; and
FIG. 9 is a longitudinal sectional view of a flow-directed catheter
embodying the invention.
DESCRIPTION OF THE PREFERRED EMBODIMENT
Tube 10 is formed as an extrusion of a suitable thermoplastic
material having a memory characteristic such as polyvinyl chloride.
This extrusion contains a large through lumen 11 of approximately
semicircular shape in cross section as shown in FIG. 7 and a small
circular balloon inflation lumen 12. The extrusion is cut off to
the desired length and the end portion which is to receive the
balloon is heated with hot water 13 as shown in FIG. 1. The heated
and softened portion of the tube is then drawn by pulling in
opposite direction with the fingers as indicated by arrows 14,
causing the softened portion 15 to neck down to reduced diameter.
This drawing step does not impair the integrity of the lumens 11
and 12.
After the drawing step, end portion 16 is cut off as shown in FIG.
2 and a pair of rigid ferrules 20 and 21 of suitable material such
as stainless steel is placed on necked portion 15. These ferrules
are placed in appropriate positions for the balloon windings and
the necked portion of the tube is reexpanded by heating with heat
lamp 22 as shown in FIG. 3. In this reexpansion step, utilizing the
memory characteristic of the plastic, necked portion 15 returns to
its original diameter forming shoulders 25 which securely lock the
ferrules 20 and 21 in place in indentations in the tube. The
ferrules preferably have an outside diameter slightly less than the
original diameter of the extrusion.
The memory characteristic referred to is the result of crystalline
structures set up within some of the polymer chains. When such
material is heated under tension, these chains tend to untangle and
straighten out. As long as the yield point is not exceeded, i.e.,
the chains are not broken, the material will return to its original
form if reheated and not constrained. One of the advantages of
polyvinyl chloride for the present purpose is that it will undergo
a great deal of elongation before reaching its yield point.
The reexpansion step in FIG. 3 also restores the lumens 11 and 12
to approximately original size. A cylindrical plug 26 of suitable
material such as polyvinyl chloride is secured in lumen 12 by a
solvent bonding material. This plug is of sufficient length to
extend from the cut end 27 of the tube to a point a short distance
on the proximal side of ferrule 21.
Then a round wire 30 is inserted temporarily in lumen 11 as
indicated in FIG. 4 and a tapered tip 31 is formed on the end of
the tube by a heated die. The heat of the die causes the outer end
portion of plug 26 to lose its identity and merge into the material
of the tube as indicated by broken lines at 32 in FIG. 6. When the
tip-forming operation is completed, wire 30 is removed leaving a
round opening 11a at the end of lumen 11. In the tip forming
operation wire 30 is held in concentric axial position within the
tube so that opening 11a will be in the center of the tube.
A plurality of balloon inflation openings 33 are formed
intersecting the lumen 12 and an elastic balloon sleeve 35 is
pulled over the tube. The ends of the balloon sleeve are secured by
windings 40 of suitable material such as Dacron thread overlying
the ferrules 20 and 21 as shown in FIG. 5. These ferrules provide a
solid backing for the windings whereby the lumens 11 and 12 are not
constricted regardless of the tightness of the windings. Windings
40 may be substantially contained within the indentations in the
tube created by the ferrules whereby the balloon portion of the
catheter has approximately the same diameter as the rest of tube
10.
In use, the catheter is passed through a vein or artery or other
body lumen until the tip reaches the area under investigation. The
proximal end of the catheter tube, not shown, is equipped with the
usual fittings providing fluid connections with the lumens 11 and
12. The introduction of balloon inflation fluid under pressure into
lumen 12 expands the balloon 35 sufficiently to occlude the body
lumen. Lumen 11 may be utilized for injection of therapeutic or
diagnostic agents, sampling of a body fluid or pressure
monitoring.
The extrusion may contain more than two lumens and a second balloon
may be applied to the tube in the same manner on the proximal side
of balloon 35 if desired.
FIG. 9 shows a highly flexible catheter embodying the invention for
introduction percutaneously into a peripheral vein for flow guide
catheterization of systemic veins, the right heart and pulmonary
vessels. Tube 50 is extruded from a suitable thermoplastic material
having a memory characteristic, such as soft polyvinyl chloride.
The method steps essentially as shown in FIGS. 1 to 5 are utilized
for application of the two rigid ferrules 51 and 52 of a suitable
material such as stainless steel. The catheter tube has a balloon
inflation lumen 53 and a through flow lumen 54, the tube being
flexible to the extent of being completely limp.
For application of the ferrules, the distal end portion of the tube
is heated and drawn out to shrink its diameter as shown in FIG. 1
and the ferrules applied as shown in FIG. 2. The heating step in
FIG. 3 utilizes the memory characteristic of the plastic to
reexpand the tube, forming shoulders 55 which lock the ferrules in
place in indentations in the tube. A longitudinal balloon inflation
slit 56 intersecting the lumen 53 is formed by a rotary cutter. The
end of lumen 53 is closed by a plug 57 and a contoured tip 58 is
die formed on the end of the tube as described in connection with
FIG. 4. Ferrule 52 is positioned very close to the end of the tube
for a reason which will presently appear.
The distal end of balloon 60 is everted under Dacron winding 61
overlying ferrule 52 and winding 62 overlying ferrule 51 is applied
to the proximal end of the balloon as shown. When the balloon is
inflated it assumes the shape as shown in broken lines at 60a
having a fold forming an annular bulge at 65 which preferably
projects beyond and, in any event, forms a guard around the tip end
58 of the catheter tube. Tip 58 is contained in a dimple in the end
of the balloon.
A second balloon may also be provided, if desired, spaced a short
distance in a proximal direction from the balloon 60 and inflated
from lumen 53 or from a second balloon inflation lumen. In such
case, four ferrules would be applied as shown in FIG. 2 instead of
two ferrules. The tube 50 may also include additional lumens 54.
When there are two balloons, there may be an additional lumen
having an external port opening between the two balloons. There may
also be a still further lumen having an external port opening on
the proximal side of the second balloon, if desired.
Balloon 60 acts as a sail to transport appropriate sensor devices
in the catheter into the central circulation. The balloon forms a
blunt body which is subjected to the drag force of the blood
flowing past it, causing the balloon to pull the catheter along
with it. For example, with the balloon deflated, the catheter may
be inserted into an ante-cubital or other peripheral vein. When the
balloon is inflated, it will flow carry the catheter through the
right heart chambers and into the smaller radicals of the pulmonary
artery so that pulmonary capillary wedge pressure may be measured.
If the balloon is deflated at this point, pulmonary arterial
pressures are measured; when the balloon is inflated, wedge
pressure is again seen. The catheter is allowed to advance to the
desired destination. Thus, the catheter in FIG. 9 may be used for
pressure monitoring, blood sampling or infusion without fluoroscopy
and with a minimal hazard to the patient. The field of use is in no
way limited, however, to the particular example described.
When the balloon 60 is inflated, the annular bulge 65 prevents
point contact of the tip of the catheter tube with the heart or
artery wall. The presence of the balloon around the tip of the
catheter alters the catheter system from one with a point force to
one with forces dispersed over a surface. This markedly reduces the
incidence and significance of ventricular extra-systoles which are
occasioned by the pressure of a catheter tip on the endocardial and
the subendocardial tissues. This is of critical importance in the
management of seriously ill patients in whom an arrhythmia, even of
transient duration, may prove to be fatal.
* * * * *