U.S. patent number 3,615,236 [Application Number 04/808,095] was granted by the patent office on 1971-10-26 for apparatus for automatic chemical analyses.
This patent grant is currently assigned to Bodenseewerk Perkin-Elmer & Co. GmbH. Invention is credited to Rolf Tamm.
United States Patent |
3,615,236 |
Tamm |
October 26, 1971 |
APPARATUS FOR AUTOMATIC CHEMICAL ANALYSES
Abstract
Automatic chemical analyses apparatus includes a known turntable
carrying a circumferentially arranged large series of (radial
arrays of) reaction vessels, into each of which a sample is placed,
and at other rotational positions of the turntable various
"sample-treating" means are located (including means for adding
reagents, means for sucking off all or part of the sample, stirring
means for mixing the various contents of the vessels, and the
like). The present apparatus includes a generally circular mounting
plate, above the turntable and slidable on a stationary vertical
guiding column (coaxial with the rotation axis of the turntable).
At various circumferential positions along the mounting plate
periphery, secondary radially extending projection plates, carrying
the various different sample-treating devices are removably
attached. Moving the entire mounting plate assembly up and down
causes the various sample-treating devices to enter into and
"clear" the various reaction vessels in the turntable. Certain
additional devices, which are always utilized at a fixed point in
the turntable cycle (e.g., means for placing samples in each of the
vessels in a particular radial array) may be positioned in between
the various peripherially attached secondary projections, without
causing any problems of physical interference, since the mounting
plate and its projections do not rotate, but only the underlying
turntable with its reaction vessels. The various peripherially
attached secondary "projections" may be disconnected and moved to
different circumferential positions on the main-mounting plate (or
projections carrying different sample-treating devices interchanged
in an analogous manner), thereby affording great versatility as to
the different types and timing of steps of analyses performed by
the described apparatus.
Inventors: |
Tamm; Rolf (N/A, DT) |
Assignee: |
GmbH; Bodenseewerk Perkin-Elmer
& Co. (DT)
|
Family
ID: |
6978507 |
Appl.
No.: |
04/808,095 |
Filed: |
March 18, 1969 |
Foreign Application Priority Data
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|
|
|
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Mar 19, 1968 [DT] |
|
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B 75 061/42 GBM |
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Current U.S.
Class: |
422/64;
73/864.23; 73/864.91; 141/130 |
Current CPC
Class: |
G01N
35/025 (20130101); F23B 2700/01 (20130101); G01N
2035/0458 (20130101) |
Current International
Class: |
G01N
35/02 (20060101); G01N 001/00 (); G01N
001/14 () |
Field of
Search: |
;23/1,1.5,1.6
;73/425.4,425.6 ;141/130 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Wolk; Morris O.
Assistant Examiner: Serwin; R. E.
Claims
I claim:
1. In an apparatus for automatically carrying out chemical analyses
of the type comprising a rotatable turntable accommodating a
plurality of series of circumferentially arranged reaction vessels
being in the form of a circle which is concentric to the circle of
each other circumferential series, and sample-treating means
adapted to enter into the various reaction vessels in at least two
different circumferential series from above, the improvement
comprising:
a mounting plate comprising a circular portion, concentric with all
said circumferential series of reaction vessels, for carrying said
sample-treating means;
a central hub portion attached to said mounting plate;
a stationary vertical guide column for movably supporting said hub
portion of said mounting plate, so as to movably guide said
mounting plate above said turntable in a vertical direction;
and means for causing vertical movement of said mounting plate and
its hub portion relative to said stationary guide column;
whereby said mounting plate and said various sample-treating means
carried thereby may be raised and lowered relative to said
turntable when said turntable is rotated to different
circumferential positions, so that said sample-treating means may
enter into and be moved out of said various reaction vessels
regardless of the particular position on said circular portion of
said mounting plate at which any said sample-treating means is
carried.
2. An improved apparatus according to claim 1, in which:
said mounting plate comprises a central part surrounding said hub,
said part having a circular exterior peripheral edge which
comprises said circular portion;
said exterior circular portion comprises, at a plurality of
peripheral locations, releasable attaching means;
at least one generally plate-shaped radial projection is provided,
comprising connection means operatively cooperating with said
releasable attaching means, so as to be attachable to said exterior
circular portion of said mounting plate at any one of said
plurality of peripheral locations;
and each said plate-shaped radial projection carries at least one
said sample-treating means adapted to engage simultaneously at
least two reaction vessels in different circumferential series;
whereby said sample-treating means may be placed at appropriate
circumferential angular locations of said mounting plate and
cooperate with at least one reaction vessel in each of any two of
said peripheral series.
3. In an apparatus for automatically carrying chemical analyses of
the type comprising a rotatable turntable accommodating
circumferentially arranged reaction vessels, and sample-treating
means adapted to enter into the various reaction vessels from
above, the improvement comprising:
a mounting plate for carrying said sample-treating means;
a central hub portion attached to said mounting plate;
a stationary vertical guide column for movably supporting said hub
portion of said mounting plate, so as to movably guide said
mounting plate above said turntable in a vertical direction;
and means for causing vertical movement of said mounting plate and
its hub portion relative to said stationary guide column, to raise
and lower said sample-treating means relative to said turntable so
that said sample-treating means may enter into and be moved out of
said various reaction vessels;
said stationary vertical guide column having a regular
even-numbered polygonal horizontal cross section;
and said hub portion carries at least three pairs of vertically
superposed rollers, each pair offset from each other by an angle so
as to abuttingly engage regularly distributed different flat side
surfaces of said vertical guide column;
whereby said hub and its rigidly attached mounting plate is
constrained from any movement in the horizontal plane, but can
freely move in the vertical direction relative to said polygonal
cross section, vertical guide column.
4. An improved apparatus according to claim 3, in which:
said regular even-numbered polygonal cross section is
hexagonal;
and said rollers comprise three superposed pairs, each pair being
offset with respect to each other by 120.degree.;
whereby each alternate or second surface of said hexagonal cross
section, vertical guide column is engaged by one pair of said
rollers.
5. An improved apparatus according to claim 3 in which:
a vertical toothed rack is rigidly attached to said hub
portion;
a rotatable gear meshes with said toothed rack;
a driving worm drive is provided;
and means are provided for operatively connecting said worm drive
to said rotatable gear;
whereby operation of said worm drive will cause rotation of said
gear, thereby raising or lowering said mounting plate.
6. An improved apparatus according to claim 5, in which:
said operatively connecting means comprises a releasable connection
of such construction that axial movement of said gear disconnects
said worm drive from said gear;
whereby said mounting plate may be manually raised independently of
said worm drive upon failure of said drive after such disconnecting
axial movement of said gear.
7. An improved apparatus according to claim 5, in which:
switch-actuating cams are rigidly attached to said hub portion of
said mounting plate;
and relatively stationary limit switches are engaged by said cams
in the various raised and lowered positions of said mounting
plate;
whereby the extent of vertical travel of said mounting plate is
controlled by said various limit switches.
Description
The present invention relates to apparatus for automatically
carrying out chemical analyses comprising a turntable accommodating
reaction vessels and sample-treating means adapted to be immersed
into the reaction vessels from above.
In this connection the sample-treating means may be for instance,
pipettes for sucking off or conducting the sample liquid, means for
admixing reagents or even means for agitating the sample substance.
These sample-treating means, during the working phase thereof, must
enter into the reaction vessels and then be fully withdrawn from
the reaction vessels during the advance movement of the turntable.
With prior art apparatus of the type indicated the sample-treating
means are individually movable and controllable. For a plurality of
different sample-treating means such as become necessary for
instance, when simultaneously carrying out several types of
analyses in serial operation on one turntable, this will lead to
constructional problems which are practically impossible to
solve.
It is the object of the present invention to provide a simple
constructional solution for the control of a plurality of upwardly
and downwardly movable sample-treating means for automatic
analytical apparatus operating with a turntable of the type
previously mentioned.
According to the present innovation this object is attained by
providing that above the turntable there is arranged a mounting
plate on which the various sample-treating means are mounted and
which is movably guided by its central hub on a guide column in a
vertical direction and is upwardly and downwardly movable in
synchronization with the turntable.
It is particularly advantageous if the mounting plate has a
circular central portion to which plate-shaped radial projections,
accommodating the sample-treating means, are attachable at
different circumferential angular positions by means of detachable
locking devices.
Then, by circumferentially displacing the projections relative the
angular position of the sample-treating means mounted on each may
be changed in a simple manner and therewith the moment of their
becoming effective in the respective analysis cycle. In the spaces
between these radial projections, further sample-treating means
independent of the mounting plate, such as, for instance, sample
supply or dosing pumps for distributing sample liquid from one
sample vessel into several reaction vessels arranged in a radial
array, may be arranged, without their operation colliding (i.e.
interfering) with the functioning of the upwardly and downwardly
movable mounting plate.
An embodiment of the present innovation will be hereinafter
described with reference to the accompanying drawings, in
which:
FIG. 1 shows a top view, partly in section, of an analytical
apparatus according to the invention;
FIG. 2 shows a side view of the apparatus, also partly in section,
and partly broken away.
The analytical apparatus (see FIG. 2) includes a turntable 1 having
inserted therein circumferentially sample and reaction vessels 2 in
radial arrays in a well-known manner. The turntable 1 constitutes a
ring with a downwardly projecting rim 3. In the rim 3 there are
supported rollers 4 with which the turntable 1 runs on a radial
flange 5 of a stationary housing wall 6.
For supporting various sample-treating means there is provided a
mounting plate 7 being upwardly and downwardly movably guided by
its sleeve-shaped hub 8 on a central guide column 17. The mounting
plate 7 has a circular central portion 9 to which plate-shaped
radial projections 10 are attachable at different angular (i.e.
circumferential) positions by means of detachable locking devices
11. These radial projections 10 carry the various sample-treating
means, which may, for instance, be suction pipes 12 which are
mounted to the radial projections 10 by means of fastening elements
13 (see FIG. 1). From the suction pipes hoses 14 extend. Further
pipes 15 and hoses 16 may be used to flush the reaction vessels
after the sample has been sucked off.
Changing the apparatus for adaption to different analytical objects
may readily be accomplished by locking the radial projections 10 at
another position on the circumference of the central portion 9. The
angular position of the various projections with their own
particular sample-treating means mounted thereon determines the
moment in the analysis cycle, at which the respective
sample-treating means become effective. The mounting plate 7 with
the projections 10 does not rotate, and the turntable 1 rotates
with periodically alternating speed or stepwise underneath this
mounting plate about a common central axis.
In the periods of low speed or periods of inoperation of the
turntable 1 the whole mounting plate executes a vertical (downward)
stroke movement. Thereby, the sample-treating means are inserted
into the respective reaction vessels disposed underneath at that
moment. When the sample-treating means have fulfilled their
function, the mounting plate will be raised, thereby completely to
withdraw the sample-treating means from the reaction vessels so
that the sample-treating means will not impede onward rotation of
the turntable 1. Thereafter, the turntable 1 may be moved one step
further, so that the respective next following radial array of
reaction vessels 2 is moved underneath the sample-treating
means.
The central guide column 17 is of substantially hexagonal cross
section. It is surrounded by the hub 8. The hub 8 has provided
therein three pairs of superposed rollers 18, 19, respectively
offset with respect to each other by 120.degree.. These rollers
each abut one side surface of the guide column 17. Thereby, the hub
8 with the mounting plate 7 is vertically movably guided on the
guide column 17. As can be seen from FIG. 2, the hub 8 may be
raised up into the position shown in dotted lines.
This raising and lowering of the hub 8 with the mounting plate 7 is
effected via a vertical tooth rack 20 rigidly mounted to the hub 8
(see FIG. 1). This tooth rack is in mesh with a gear 21. The gear
is driven via a worm wheel 22 and a worm 23, by means of a coupling
comprised of a radial pin 24 on the shaft of the worm wheel 22 and
an axial pin 25 at the gear 21. The gear 21 is axially
disengageable against the action of springs 26, without getting out
of mesh with the tooth rack 20. By axial disengagement of the gear
21, the coupling 24, 25 may be released, thereby rendering possible
manual raising of the mounting plate after release of the coupling
(also manually) in the event of failure of current or other failure
which interrupts the drive via the worm wheel 22 and the worm 23.
Control of the vertical extent of travel of the mounting plate is
effected by limit switches 27, 28, 29 actuated by cams 30 on the
hub 8.
Attachment of the radial projections 10 to the central portion 9 of
the mounting plate 7 is effected by locking devices 11, as best
seen in FIG. 2. The central portion 9 has a peripheral groove 31.
Below the groove the central portion projects outwardly as at
32.
The projection 10 is inserted into the groove by means of an
integral tongue 33 thereof, having a bore 34 therein. In a
corresponding bore of the central portion 9 there is disposed a
drop-in ball 35 being under the influence of a leaf spring 36. This
drop-in ball engages into the bore 34 and acts on that edge of bore
34, shown on the left in FIG. 2. Thereby, the spring-urged ball 35
tends to draw the tongue 33 of the projection 10 leftwardly, thus
towards the central portion 9. The correct circumferential angular
position of the projections 10 is ensured by semicircular guide
members 37 which are provided around the total circumference of the
central portion 9 and cooperate with corresponding quadrant-shaped
recesses 38 on the inner side of the projections 10 in order to
align the projections 10. In the spaces between the projections 10,
a sample dosing and distributing pump, for instance, as indicated
at 39 in FIG. 2, may be separately movably mounted, both radially
and upwardly and downwardly, as schematically indicated by the
arrows directly above element 39.
* * * * *