U.S. patent number 3,613,879 [Application Number 04/851,166] was granted by the patent office on 1971-10-19 for suture packaging.
This patent grant is currently assigned to Philip Morris Incorporated. Invention is credited to Mern S. Kemble.
United States Patent |
3,613,879 |
Kemble |
October 19, 1971 |
SUTURE PACKAGING
Abstract
A package for sutures which are contained under conditions of
complete sterilization is disclosed with a method for in-line
sterilization packaging of the objects on mass production basis.
The package includes a hermetically sealed inner packet in which
the suture material is received and which has at least initially, a
sterilizing gas confined therein, the inner packet in turn being
received in an outer packet of the same general construction as the
inner packet and which also is hermetically sealed and initially
has a sterilizing gas confined therein. The package is made by
filling the inner packet blister with the suture material, then
tacking a lid onto the blister and confining the inner packet in a
vacuum chamber to remove air from the inner packet. Sterilizing gas
is then admitted to the chamber for killing any bacteria on the
suture material. The lid is then sealed to an associated blister
while still in the chamber so that a quantity of the sterilizing
gas is captured within the sealed inner packet. The sealed inner
packet is then removed from the vacuum chamber and placed in an
outer packet blister and a closure lid tacked in place on the
blister. The outer packet is then subjected to the same
sterilization and packaging procedures as the inner packet.
Inventors: |
Kemble; Mern S. (Deerfield,
OH) |
Assignee: |
Philip Morris Incorporated (New
York, NY)
|
Family
ID: |
25310118 |
Appl.
No.: |
04/851,166 |
Filed: |
August 19, 1969 |
Current U.S.
Class: |
206/210; 206/438;
206/524.8; 206/223; 206/467 |
Current CPC
Class: |
A61B
17/06133 (20130101); B65D 75/32 (20130101); B65D
75/326 (20130101); A61F 15/001 (20130101); B65D
2575/3245 (20130101) |
Current International
Class: |
A61F
15/00 (20060101); A61B 17/06 (20060101); B65D
75/28 (20060101); B65D 75/32 (20060101); A61i
017/02 () |
Field of
Search: |
;206/43,46PV,46SG,46ST,56A,56AA,56AB,63.2,63.3,45.34,78B |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
|
|
|
|
|
|
|
810,664 |
|
Mar 1959 |
|
GB |
|
878,913 |
|
Oct 1961 |
|
GB |
|
1,457,812 |
|
Nov 1966 |
|
FR |
|
Primary Examiner: Leclair; Joseph R.
Assistant Examiner: Lipman; Steven E.
Claims
I claim:
1. A package for a sterile surgical object comprising an inner
packet including a blister in which the surgical object is
received, and a closure lid covering said blister and secured
thereto in condition of substantially hermetic heat sealing along a
continuous path, and
an outer packet, said outer packet comprising a blister in which
the sealed inner packet is received, and a closure lid covering
said outer blister and secured thereto in condition of
substantially heremetic heat sealing along a continuous path,
said closure lids each comprising a sheet of a foil of a metal
including a layer of plastic material covering thereon to permit
heat sealing of said lids to said blisters,
the blisters of said inner and outer packets being generally
similarly shaped relatively rigidized boxlike transparent
structures of thermoplastic material each having a deep main body
and encircling flanges outstanding from the main bodies thereof,
said flanges providing surfaces to which said closure lids are
secured, a length of each closure lid along a portion thereof which
is coextensive with an end flange of its associated blister being
left unsealed to thereby provide tab means for initiating peelably
removing said closure lids from said blisters,
said inner packet being received in inverted position in the
blister of said outer packet, the closure lid of said inner packet
being of a length in excess of that of its associated blister, such
excess length being folded up and over an edge of said blister to
provide a grasping tab with which said inner packet can be grasped
for removing same from said outer packet,
both said inner and outer packets containing a sterilizing gas
mixture of ethylene oxide and an inert gas under positive pressure
up to one p.s.i.g.,
the condition of heat sealing with which the closure lids of both
said packets are secured to their associated blisters being
effective to substantially retard the rate of gas inflow and
outflow from said packets, said condition of sealing being further
characterized by allowing for readily peelably removing said lids
from said blisters.
Description
BACKGROUND OF THE INVENTION
It is known to package sterile surgical objects, as for example,
suture material in sterilized packages which include an outer
sealed package component enclosing a sterile, fully sealed inner
package component enclosing a sterile, fully sealed inner package
component, the latter in turn containing the surgical object. It is
also known to confine in the inner component of a plural component
package along with a surgical object, a sterilizing medium or agent
such as a tubing solution to effect complete sterilization of the
surgical object within the package over a period of time, the
tubing solution in some instances remaining in the sealed inner
package component until the package is opened preliminary to using
the surgical object. Such packages however generally embody
features of package construction which make it difficult to confine
a sterilizing gas within both the inner and outer package
components so that such gas can provide for at least some initial
post packaging period, a total package sterilization during
post-packaging storage nor do such packages or manufacturing
techniques as are known allow for modern in-line sterilization
packaging of surgical objects in bulk or continuous mass production
basis.
The present invention on the other hand overcomes the
above-mentioned shortcomings of prior art surgical object packaging
and is characterized by its suitability for high speed, reliable
in-line sterilization packaging. In addition to providing a new and
improved method of packaging surgical objects, the present
invention provides an improved package for sterilized surgical
objects.
SUMMARY OF THE INVENTION
In accordance with the present invention an improved package for
sterile surgical objects is provided which includes a completely
sealed inner packet in which the surgical object is received and an
outer packet in which the sealed inner packet is received. The
surgical object can be any of a variety of such objects which are
required to be rendered and maintained sterile until the time of
use by the surgeon, one such object, for example, being suture
material. The inner packet providing enclosure structure for the
surgical object includes a boxlike bottom or blister having depth,
width and length dimensions sufficient to accommodate the surgical
object and also having a continuous encircling flange extending
outwardly of the blister body to serve as a surface to which a
peelably removable lid can be heat sealed to provide a
substantially hermetic seal of the inner packet. The inner packet
lid preferably comprises a flexible sheet of metallic foil coated
on one broad face with a layer of a plastic material adapted to
provide means for effecting heat sealing of the lid to the blister.
The inner packet lid can be of somewhat greater length than its
associated blister to allow for folding of such excess length over
and under a projecting end flange portion of the blister,
preferably along one transverse edge of the blister and being
provided as a tab means for the purpose of readily grasping the
inner packet to remove it from the outer packet and also to readily
initiate peeling away of the lid to expose the surgical object. The
outer packet preferably is of substantially identical construction
with the inner packet but is of sufficiently larger dimensions to
house or receive the inner packet. The outer packet comprises a
boxlike bottom or blister provided with a continuous encircling
flange and adapted to receive therein in inverted position, a
sealed inner packet. The outer packet also is provided with a lid
secured in substantially hermetically heat-sealed condition to the
flanges of the outer packet blister. Both the inner and outer
packets at least initially have a sterilizing gas confined therein
which functions during at least some of the period of
post-packaging storage and handling of the package to insure the
sterile condition of the surgical object. To open the package, the
outer packet lid is peeled off its associated blister to expose the
sterile inner packet. The inner packet then can be grasped by the
tab means of its lid and removed from outer packet blister
whereupon the inner packet lid can be peeled off its associated
blister to expose the surgical object for use by the surgeon.
According to the present invention, in-line mass production
packaging of surgical objects can be carried out. For this purpose
a continuous stock of upright laid inner packet blisters are
advanced to a station at which they are each filled with a surgical
object, after which lids are positioned on the flanges of the
blisters and are tack sealed to such flanges at a number of points
only so that fluid access to the inner packet is possible. The
filled inner packets are then advanced in succession into a vacuum
chamber and subjected to a condition of vacuum so as to withdraw
air from the interior of the chamber and inner packet. The vacuum
is then broken by admitting sterilizing gas under positive pressure
only slightly above atmospheric pressure, the sterilizing gas
serving to initiate killing any bacterial agency in or on the
surgical object or the interior of the inner packet. The inner
packet lid is then completely heat sealed to its associated blister
flanges while still in the chamber and while subjected to the
presence of the sterilizing gas and with the consequence that a
quantity of the sterilizing gas becomes captured within the inner
packet. The completely sealed inner packets are then removed from
the chamber and advanced to another station whereat they are
inserted in inverted position in outer packet blisters. The outer
packet lids are then tack-sealed to the associated blisters after
which the packages are advanced in succession into a vacuum chamber
and exposed to a condition of vacuum. Sterilizing gas is then
admitted to the chamber to initiate killing bacterial agency on the
exterior of the inner packet and interior of the outer packet
following which the outer packet lids are completely sealed to
their blisters in the same manner attending sealing of the inner
packets.
The invention accordingly comprises the several steps and the
relation of one or more of such steps with respect to the others as
will be exemplified in the process to be described as well as the
features of construction, combination of elements and arrangement
of parts exemplified in the construction hereinafter set forth and
the scope of the invention will be indicated in the claims.
BRIEF DESCRIPTION OF THE DRAWINGS
A fuller understanding of the nature and objects of the invention
will be had from the following detailed description taken in
conjunction with the accompanying drawings in which:
FIG. 1 is a perspective view of a sterilized suture package
constructed in accordance with the principles of the present
invention, the peelably removable lid of the outer packet being
shown partly removed.
FIG. 2 is a plan view of the suture package shown in FIG. 1,
showing the peelably removable lid almost completely stripped off
from the outer packet blister.
FIG. 3 is a longitudinal sectional view of the sterilized suture
package shown in FIGS. 1 and 2 as taken along the line III--III in
FIG. 2, the removable lid of the outer packet being shown in its
fully sealed position of closure on its associated blister.
FIG. 4 is a perspective view of the inner packet in which coiled
suture material is contained, the inner packet being shown in its
sealed condition with the pull tab of the lid with which initiation
of peeling of the packet lid is effected being shown folded under a
projecting flange portion of its associated blister.
FIG. 5 is a block diagram of the several steps involved in
continuous or bulk packaging operations with which suture packages
of the present invention can be made.
Throughout the description, like reference numerals are used to
denote like parts in the drawing.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
The present invention provides an improved package for sterile
surgical objects as well as a method of in-line sterilization of
such packages on mass production basis. Although "sterile surgical
objects" will be exemplified herein by way of example as being
suture material and the packaging of the same, it will be
understood that the present invention has broader application being
useful for packaging objects of wide description wherein the basic
consideration is establishment and maintenance of a totally
sterilized package. In the following description, the construction
of the improved package for sterile surgical objects will be
discussed first.
As can be noted from the accompanying drawings and with particular
reference to FIGS. 1 and 3, the package 10 it will be noted is
comprised of two major components, a substantially hermetically
sealed inner packet 12 in which is received the surgical object 14,
and a substantially hermetically sealed outer packet 16 in which
the inner packet 12 is received. The surgical object 14 is shown by
way of example as being a coil of suture material wound on a card
support and including the usual suturing needle. The inner packet
12 and outer packet 16 preferably are substantially identical in
construction differing essentially only as to size. The outer
packet 16 includes a boxlike bottom section or blister 18 which is
a shaped, relatively rigidized structure and preferably made from a
transparent plastic material and which is provided with
outstanding, encircling flanges 20, the latter being of
comparatively greater dimension along one transverse edge as at 22
for a purpose which shall appear. The outer packet 16 also includes
a closure member or lid 24 which is generally coextensive with the
plan expanse of its associated blister and which is comprised of a
layer of metallic foil 26 coated at its underface with a layer of a
thermoplastic material 28, the latter being provided to enable
effecting a heat seal of the lid 24 to the flanges of the blister
18, the heat seal being along a continuous encircling course, the
pattern of which may be best seen as denoted by the seal line 30 in
FIGS. 1 and 2 and the seal connections 30' in FIG. 3. The quality
of the heat seal is such as to provide a substantially hermetic
seal closure of the outer packet. As used herein, a substantially
hermetic seal is intended to mean a condition of seal which
substantially retards for a period of time, e.g., 1 week to 10
days, the rate of dissipation of sterilizing gas under pressure
from the sealed packets. As can be noted from FIGS. 1-3 an end
portion of the lid 24 is not sealed to the blister flange along
edge area 22 so that convenient digital access is available for
peelably removing the lid from the blister when opening the
package.
As was indicated earlier, the outer packet 16 receives the inner
packet 12. The inner packet 12 in turn receives and contains the
surgical object 14. The inner packet 12 as can be noted from FIGS.
3 and 4 and like outer packet 16, includes a boxlike bottom or
blister 32 and a flexible closure lid 34, the blister 32 being
provided with flanges in the same manner as blister 18 to serve as
surfaces to which the closure lid 34 can be heat sealed. However,
closure lid 34 has a somewhat greater length than blister 32 so
that such excess length can be folded around and under one
transverse flange of blister 32 to thereby provide tab means 36 for
grasping the inner packet 12 when removing it from the outer packet
and also for initiating peeling off of the lid 34 from blister 32.
As can be seen in FIG. 3, the inner packet 12 preferably is
received in inverted position in the outer packet 16 so that the
lid thereof which can be marked with identifying indicia can be
viewed readily.
The package 10 when sealed is completely sterilized and during post
packaging storage and handling remains so with respect to the
interior of the outer packet and both the exterior and interior of
the inner packet. That this condition of sterilization obtains is
due, inter alia, to the hermetic seal of each packet and to the
presence of sterilizing gas within each packet. While the
sterilizing gas is initially confined with each packet at some
positive pressure above atmospheric and preferably not greater than
1 p.s.i.g., it will dissipate from the packages at a very slow rate
due to the character of the heat seal. Moreover, the character of
the heat seal is such as to function as a filter to prevent the
incursion of bacterial agency media and hence the package retains
its sterile quality although the sterilizing gas may have long been
dissipated therefrom. The sterilizing gas can be any known gaseous
medium suited for the intended purpose. A mixture of ethylene oxide
and inert gas such as carbon dioxide or freon gas in percentages of
about 12 percent ethylene oxide and 88 percent inert gas is a
particularly effective sterilizing gas.
To open package 10, the user first peels off lid 24 from outer
packet 16 in the manner shown in FIGS. 1 and 2. The inner packet 12
is then removed from blister 18 by grasping the inner packet 12 at
tab means 36. The inner packet is then opened in the same manner to
expose the surgical object 14 which can be removed directly by the
surgeon without having been touched by any other person or object
which could be a cause of contamination.
Description now will be given of the improved method by which
sterile surgical objects can be packaged in an in-line or bulk
sterilization process, for which purposes continuing reference is
made to FIG. 5. The present invention as has been stated earlier
provides that suture packages can be made most readily on mass
production basis. The apparatus with which such packages can be
made can be of known construction provided it is capable of
performing the functions now to be described. A continuous supply
of individual surgical objects are, at an appropriate loading
station, laid in inner packet blisters. The inner packet blisters
if the operation is to be a bulk sterilization can be formed as a
plurality of such blisters, e.g., ten in a sheet. The filled
upright arranged inner packet blisters then have their associated
closure lids positioned thereon as they advance along the
production line and the lids are tack sealed to the blisters. The
inner packets are then advanced in successive order or bulk
quantity into a suitable conditioning chamber and a vacuum is drawn
in the chamber to subject the inner packets to a condition of
vacuum as so to withdraw air from both the chamber and the interior
of the inner packets. The degree of vacuum can vary from about 1 to
about 29 in. Hg., a particularly preferred operating range being
5-29 in. Hg. As soon as the vacuum in the chamber has pulled down
to the desired level, it is broken by admitting a flow of
sterilizing gas under positive pressure into the chamber. The
sterilizing gas can be any one of a number of such sterilizing
agents as are known, a particularly suitable gas for this purpose
being a mixture of ethylene oxide and an inert gas such as carbon
dioxide or freon in proportions of about 12 percent of the former
and 88 percent of the latter with the gas pressure being varied
depending upon the requirements of the packaging. However, for the
package shown in FIGS. 1-4, a pressure of about 1 p.s.i.g. is
particularly suitable. As soon as the sterilizing gas invests the
inner packets it immediately initiates killing of any bacterial
agency in or on the inner packets and the surgical objects. As soon
as the requisite pressure of sterilizing gas is reached within the
chamber, the inner packets are then completely sealed by heat
sealing the closure lids to the flanges of the associated blisters,
such heat sealing being effected within the chamber with the gas
pressure being maintained until sealing is completed.
The sealed inner packets are then removed in succession from the
chamber and advanced to a station at which they are placed in
inverted position in outer packet blisters and whereupon lids are
tack sealed to the outer packet blisters, the respective sealed
inner packets of course will at this point if they are made in bulk
be separated from the base sheet. Similarly if the operation is a
bulk one, the individual sealed inner packets may be received in
the outer packet blisters while the latter are still joined in bulk
from a single formed sheet. The filled but yet unsealed outer
packets are then advanced into a chamber and subjected to the
vacuum-treating gas exposure and lid sealing in the same manner as
applicable to the inner packets. The thus finished package is
completely sterilized on the inside of the outer packet and both
the inside and outside of the inner packet. Moreover, both the
inner and outer packets are filled with sterilizing gas which is
retained for an initial period in the respective packets during
post-packaging periods and dissipated only slowly therefrom due to
the heat seal connection of the closure lids to the blisters which
is effective to substantially retard the rate of gas inflow or
outflow from the packets.
It will be thus seen that the objects set forth above, among those
made apparent from the preceding description, are efficiently
attained, and since certain changes can be made in the above
construction and different embodiments of the invention could be
made without departing from the scope thereof, it is intended that
all matter contained in the above description or shown in the
accompanying drawing shall be interpreted as illustrative and not
in a limiting sense.
* * * * *