U.S. patent number 3,604,594 [Application Number 04/830,289] was granted by the patent office on 1971-09-14 for pressure pumping system with sealed pressure container.
This patent grant is currently assigned to Technicon Corporation. Invention is credited to Jack Isreeli, Aaron Kassel.
United States Patent |
3,604,594 |
Isreeli , et al. |
September 14, 1971 |
PRESSURE PUMPING SYSTEM WITH SEALED PRESSURE CONTAINER
Abstract
New and improved pressure pumping system with sealed pressure
container is provided and comprises means to supply the fluid to be
pumped to said sealed pressure container from a substantially open,
nonpressurized source thereof, and means to pressurize said sealed
pressure container to pump said fluid therefrom. Means are
additionally provided to maintain the level of said fluid within
said sealed pressurized container substantially within a
predetermined range.
Inventors: |
Isreeli; Jack (Mamaroneck,
NY), Kassel; Aaron (Brooklyn, NY) |
Assignee: |
Technicon Corporation
(Tarrytown, NY)
|
Family
ID: |
25256681 |
Appl.
No.: |
04/830,289 |
Filed: |
June 4, 1969 |
Current U.S.
Class: |
222/64 |
Current CPC
Class: |
G01N
35/08 (20130101) |
Current International
Class: |
G01N
35/08 (20060101); B67d 005/08 () |
Field of
Search: |
;222/64,67,68,56,129.1 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Tollberg; Stanley H.
Claims
While we have shown and described the preferred embodiment of our
invention, it will be understood that the invention may be embodied
otherwise than as herein specifically illustrated or described, and
that certain changes in the form and arrangement of parts and in
the specific manner of practicing the invention may be made without
departing from the underlying idea or principles of this invention
within the scope of the appended claims.
1. A pressure-pumping system for the pumping of a fluid therefrom
at substantially constant flow rate comprising, a pressure
container having fluid inlet means and fluid outlet means,
respectively, means to supply said fluid to said container through
said fluid inlet means, means to pressurize said container at
substantially constant pressure to pump said fluid therefrom
through said fluid outlet means at substantially constant flow
rate, means operative in response to the level of said fluid within
said pressure container to control said fluid supply means and
maintain said fluid level within a predetermined range within said
pressure container, said fluid supply means comprising a container
of said fluid, and said fluid supply means and said means to
pressurize said pressure container comprising pump means having
inlet means extending into communication with said container of
said fluid and outlet means extending into communication with said
pressure container, fluid directing means disposed in said pump
inlet means and operative in a first condition thereof to direct
air into said pump inlet means for pressurization of said pressure
container by said pump means, and operative in a second condition
thereof to direct said fluid from said fluid container into said
pump inlet means for supply by said pump means to said pressure
container, means operatively connecting said means to control the
level of said fluid in said pressure container with said
fluid-directing means to operate the latter between said first and
second conditions thereof in accordance with said fluid level in
said pressure container, and means operatively associated with said
pressure container to prevent the pressure therein from exceeding a
predetermined maximum.
2. A pressure pumping system as in claim 1 wherein, said container
of said fluid is open to atmospheric pressure.
3. A pressure pumping system as in claim 1 wherein, said pump means
are continuously operable during operation of the system.
4. A pressure pumping system as in claim 3 wherein, said container
of said fluid is open to atmospheric pressure.
5. A pressure pumping system as in claim 1 further comprising, high
fluid flow-resistance means of predetermined internal flow diameter
and length connected in said pressure container outlet means, and
temperature control means operatively associated therewith for
maintaining the temperature of said fluid flowing therethrough at a
substantially constant level.
6. A pump system for an analytical conduit means, which analytical
conduit means has a continuous flow and relatively low fluid flow
resistance, and which resistance is subject to variation, for
transmitting fluids, including liquid, therethrough, at a
substantially constant rate of flow despite any such variation in
resistance, comprising: a sealed container for liquid to be pumped
having an outlet, means for supplying gas to said container to pass
liquid therefrom along said outlet, a liquid reservoir open to
atmospheric pressure, liquid supply means coupled to and between
said reservoir and said container, a conduit for receiving said
liquid from said container coupled to and between said outlet and
said analytical conduit means and having a high-resistance coil
crating a high resistance to fluid flow therein, and temperature
control means for maintaining said coil at a substantially constant
temperature for precluding variations in the viscosity of said
liquid passing therethrough, whereby the rate of flow along said
analytical conduit means is maintained substantially constant.
7. A pump system as defined in claim 6, wherein: said means for
supplying gas to said container comprises a pressurized container
of said gas.
8. A pump system as defined in claim 6 wherein: said means for
supplying gas to said container and said liquid supply means
comprise a pump alternately operable to pump gas and liquid to said
container.
Description
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to a new and improved pressure pumping
system with sealed pressure container and, more specifically, to
such system as is particularly adaptable for use in automatic,
sequentially operable blood sample analysis means.
2. Background of the Invention
Although pressure pumping systems are known as described in greater
detail hereinbelow for the supply of liquids in the nature of
suitable color-producing reagents to automatic, sequentially
operable constant flow rate blood sample analysis systems in the
nature, for example, of those disclosed in U.S. Pat. No. 3,241,432
issued March 22, 1968 to Dr. Leonard T. Skeggs, et al., it may be
understood that certain significant problems do arise in such use
of the said prior art pressure pumping systems. More specifically,
it may be understood that such prior art systems rely upon covered,
pressurized reagent containers of relatively low reagent capacity
to give rise to the problem, in the event that the said containers
are not properly recovered after replenishment of the reagent
supply therewithin, of hazardous leakage of highly pressurized
reagent with resultant loss of the requisite substantially constant
system reagent flow rate. In addition, and since the said
relatively low capacity reagent containers are pressurized, it may
be understood that the requisite periodic replenishment of the
reagent supply therein will, of course, require correspondingly
periodic system shutdown with resultant undesirable loss in system
operating time.
OBJECTS OF THE INVENTION
It is, accordingly, an object of this invention to provide a new
and improved pressure pumping system with sealed pressure container
wherein the container for the fluid to be pumped at substantially
constant flow rate is a sealed pressure container.
Another object of this invention is the provision of a pressure
pumping system as above wherein the supply container for the fluid
to be pumped is a substantially open, nonpressurized container, the
supply of the fluid in which may be periodically and conveniently
replenished without effect upon system operation.
Another object of this invention is the provision of a pressure
pumping system as above which includes means for automatically
controlling, in noncritical manner, the level of said fluid within
said sealed pressure container.
A further object of this invention is the provision of a pressure
pumping system as above which requires the use of only readily
available components of proven dependability in the fabrication
thereof to accordingly provide for long periods of satisfactory,
maintenance-free system operation.
A further object of this invention is the provision of a pressure
pumping system as above which, in one form thereof, is complete
within itself and does not require any external source of system
pressurization.
A still further object of this invention is the provision of a
pressure pumping system as above which is particularly, though not
exclusively, adapted for use in the in the supply of liquids in the
nature of suitable color-producing reagents at substantially
constant flow rate to automatic, sequentially operable blood sample
analysis systems.
SUMMARY OF THE INVENTION
As currently preferred, the new and improved pressure-pumping
system of the invention comprises a sealed pressure container
having fluid inlet and outlet means. Pump means are provided to
supply the fluid to be pumped from a substantially open,
nonpressurized container thereof through said inlet means to said
sealed pressure container, and means are provided to pressurize the
latter at substantially constant pressure to pump said fluid
therefrom through said outlet means. Fluid level control means are
provided with said sealed pressure container and are operative to
control said pump means in accordance with the level of said fluid
in said sealed pressure container to maintain the latter within a
predetermined range. In a first form of the invention, said
container pressurization means take the form of an independent
source of a suitably pressurized, distinct fluid which is connected
to said sealed pressure container, while in a second form of the
invention, said pressurization means take the form of said pump
means, and fluid-directing means which are operatively associated
therewith and with said fluid level control means and which are
operable to enable pressurization of said sealed pressure container
by said pump means.
BRIEF DESCRIPTION OF THE DRAWINGS
The above and other objects and advantages of this invention are
believed made clear by the following detailed description thereof
taken in conjunction with the accompanying drawings wherein:
FIG. 1 is a schematic flow diagram of a pressure-pumping system
constructed and operative in accordance with the principles of the
prior art;
FIG. 2 is a flow diagram of a first form of a pressure-pumping
system constructed and operative in accordance with the teachings
of this invention; and
FIG. 3 is a schematic flow diagram of a second form of a
pressure-pumping system constructed and operative in accordance
with the teachings of this invention.
BRIEF DESCRIPTION OF THE PRIOR ART
A pressure-pumping system constructed and operative in accordance
with the principles of the prior art for use in fluid analysis
system is indicated generally at 10 and may, for example, take the
form of that shown and described in the copending application Ser.
No. 712,431 of Edward B. M. DeJong filed Mar. 12, 1968 and assigned
to the assignee hereof.
More specifically, the pressure-pumping system 10 comprises a tank
12 of a suitably inert gas at suitable pressure, as for example
nitrogen at 2,200 p.s.i. connected as shown through suitable
pressure regulator means 14 to a branched conduit or manifold 16 to
maintain the latter at a substantially constant pressure in the
order, for example, of 66.8 cm. Hg.
Flasks 18 and 20, including screw-on covers 22 and 24,
respectively, are provided and may be understood to respectively
contain liquids in the nature, for example, of color-producing
reagents for use in the fluid analysis system in the event the
latter is constituted by a blood sample analysis system as
discussed hereinabove, and the respective interiors of the said
flasks are connected as shown by relatively short inlet conduits 26
and 28 to the branched conduit 16.
An outlet conduit 30 connects the interior of flask 18 to the inlet
of a high flow resistance coil 32, and a conduit 34 connects the
outlet of the coil as indicated to the fluid analysis system. In
like manner, an outlet conduit 36 connects the interior of flask 20
to the inlet of a high flow-resistance coil 38, and a conduit 40
connects the outlet of the coil as indicated to the fluid analysis
system.
For use in a representative blood sample analysis system, the
respective internal diameters of the high flow-resistance coils 32
and 38 are made relatively small on the order, for example, of
0.010 inch or 0.25 mm., while the respective lengths thereof are
made relatively long on the order, for example, of 210 inches for
liquids, to provide the desired high flow impedance and attendant,
relatively low flow rates. In addition, the respective high flow
resistance coils 32 and 38 would be disposed in a temperature
control bath as indicated in dashed lines at 42 which operates at a
suitable temperature as, for example, 37.degree. C. to maintain the
liquids passing through the said coils at substantially constant
viscosity. If desired, the respective flasks 18 and 20, and the
respective entireties of the outlet conduits 30 and 36 may also be
disposed in the said temperatures control baths.
In operation, the gas from container 12 will pressurize the
respective interiors of flasks 18 and 20 to force the liquids
therefrom through the respective high flow-resistance coils 32 and
38 and therefrom, through conduits 34 and 40 at predetermined,
substantially constant flow rates.
The flow rates of the liquids through the respective high
flow-resistance coils 32 and 38 are determined by the
Hagen/Poiseuille equation:
Q=.DELTA.P.pi.D.sup.4 /128 uL wherein:
Q is the flow rate;
.DELTA.P is the pressure drop across the coil;
D is the internal coil diameter;
u is the viscosity of liquid; and
L is the effective length of the coil.
Since the respective flasks 18 and 20 are, of course, highly
pressurized during system operation, it may be understood that any
failure to properly retighten the respective covers 22 and 24
thereof on the part of the system operator after replenishment of
the supplies of reagents therein, as has in fact been observed to
occur, will, of course, result in the hazardous leakage of highly
pressurized reagent therefrom with attendant loss of the requisite
constant reagent flow rate and resultant total system disability.
Too, it may be understood that since the said flasks are, of
necessity, of somewhat limited capacity, the respective reagent
supplies therein must, of course, being periodically replenished
and, since the system is pressurized, such reagent supply
replenishment will require system shutdown with attendant
undesirable loss in system operating time.
DETAILED DESCRIPTION OF THE INVENTION
Referring now to FIG. 2, a first form of a new and improved
pressure-pumping system with sealed pressure container constructed
and operative in accordance with the teachings of this invention
for use, for example, in the supply of suitable color-producing
reagents at substantially constant flow rate to automatic,
sequentially operable blood sample analysis systems as discussed
hereinabove with regard to said U.S. Pat. No. 3,241,432, is
indicated generally at 44 and maybe seen to comprise an open
reagent supply container 46.
A pump which may take any suitable form is indicated at 48, and the
same includes a pump inlet conduit 50 which extends as shown into
the lower portion of the reagent supply container 46.
A pressure container is indicated at 52 and the pump outlet conduit
54 extends thereinto as shown to enable the pumping of reagent from
tee reagent supply container 46 to the pressure container 52 as
should be obvious.
A container of a suitably pressurized and chemically inert gas in
the nature, for example, of nitrogen at 2,200 p.s.i. is indicated
at 56 and is connected as shown through suitable pressure regulator
means 58 and conduit 60 to the interior of the pressure container
52 to suitably pressurize the latter.
An outlet conduit 26 extends as shown from the lower portion of the
pressure container 52 to without the latter and a high
flow-resistance coil 64 is connected as shown in the said outlet
conduit. Preferably, a substantial portion of the outlet conduit
62, and the entire extent of the high flow-resistance coil 64, are
immersed as shown in temperature control bath means 66 to maintain
the temperature of the reagent flowing therethrough substantially
constant and, in conjunction with the viscosity of the reagent, the
pressure in the pressure container 52, and the respective length
and internal diameter of the high flow-resistance coil 64, maintain
the reagent flow rate through the said coil substantially constant
for delivery therefrom to the blood sample analysis system as
indicated by the arrow in the drawings.
Liquid level control means are indicated schematically at 68, and
may be understood to be cooperatively associated as depicted with
the pressure container 52, and with the pump 48 as indicated by the
control line 70 extending therebetween, respectively, in such
manner as to be operative to control the level of reagent in the
said pressure container through suitable control of the operation
of the said pump. More specifically, it may be understood that the
said liquid level control means may take any suitable form in the
nature, for example, of photoelectric or float operated switch
means, which are in turn operative to energize and deenergize the
pump 48 in accordance with the reagent level in the pressure
container 52 to substantially maintain the said reagent level at a
predetermined point or within a predetermined range in the said
container.
Referring now to the form of the pressure pumping system with
sealed pressure container of the invention as indicated generally
at 72 in FIG. 3, it may be understood that the same incorporates
many of the components of the system form of FIG. 2 and that the
said components are identified by the same reference numerals in
each of the said FIGURES.
In the system form 72 and FIG. 3, however, the pump 48 is
continuously operable, and a three way valve is indicated at 74 and
is disposed as shown in the pump inlet conduit 50 to control
reagent flow therethrough. More specifically, the three way valve
74 may be seen to include a valve port 76 which is in communication
with the atmosphere, and the said valve may be understood to be
operative, in a first position thereof, to connect valve port 76 to
the pump inlet conduit 50 with resultant pumping of air rather than
reagent into the pressure container 52, and to be operative, in a
second position thereof, to close valve port 76 and enable the
pumping of reagent from the reagent supply container 46 to the
pressure container 52.
Preferably, the three way valve 74 is operated between said first
and second positions thereof by a valve-operating solenoid as
indicated at 78, and it may be understood that the said
valve-operating solenoid is in turn controlled from the liquid
level control means 68 through control line 70 in such manner that
the said valve will be moved to said second position thereof only
when the reagent level in the pressure container 68 falls below
said predetermined point to thus enable replenishment of the
reagent supply in pressure container 52 by pump 48.
Alternatively, or that is to say with the three way valve 74 in
said first position thereof, it may be understood that operation of
the pump 52 and thus eliminate the need for the separate
pressurization means 56, 58 and 60 of the system form 44 of FIG.
2.
A pressure relief valve 80 is provided as shown in the upper wall
of the pressure container 52 to control the pressure to which the
same is pressurized by the pump 48 when the three way valve 78 is
in said first position thereof.
OPERATION
In the operation of the system form 44 of FIG. 2, the
pressurization of the pressure container 52 at substantially
constant pressure from the pressurization means 56, 58 and 60 will
be effective to force reagent therefrom for flow at substantially
constant flow rate to the blood sample analysis system through
outlet conduit 62 and high flow-resistance coil 64.
As soon as the level of the reagent within the pressure container
52 falls below a predetermined point as established by the location
and/or arrangement of the liquid level control means 68 relative to
the said pressure container, it may be understood that the said
control means will be effective to energize pump 48 to replenish
the supply of reagent in the pressure container 52 from open
reagent supply container 46. Once such reagent replenishment has
been effected to the extent necessary to return the reagent level
within the pressure container 52 to or above said predetermined
point, the liquid level control means 68 will be effective to
deenergize the pump 48 and maintain the same deenergized until
reagent replenishment within the pressure container 52 is again
required.
The operation of the system form 72 of FIG. 3 is generally similar
to that of the system 44 of FIG. 2 with the exception that, in the
former, the pump 48 is continuously operable and functions to both
periodically replenish the supply of reagent within the pressure
container 52 as well as to pressurize the latter for reagent
pumping purposes at constant flow rate to the connected blood
sample analysis system.
More specifically, with regard to the operation of the system form
72 of FIG. 3, it may be understood that with the reagent level at
or above the predetermined point in the pressure container 52, the
liquid level control means 68 will be effective to operate
valve-operating solenoid 78 to place three way valve 74 in said
first position thereof to enable pump 48 to pump air through valve
port 76 into the pressure container 52 to pressurize the latter to
the predetermined pressure as established by the setting of
pressure relief valve 80.
Alternatively, once the level of reagent in pressure container 52
falls below said predetermined point, it may be understood that the
liquid level control means 68 will be effective to operate
valve-operating solenoid 78 to place three way valve 74 in said
second position thereof to enable the pumping of reagent by pump 48
from the open reagent supply container 46 to the pressure container
52 to suitably replenish the reagent supply within the latter.
Of particular interest, and advantage, with regard to both of the
pumping system forms 44 and 72 is the fact that the height or head
of the reagent supply within the pressure container 52 is by no
means critical to constant pressure and reagent flow rate system
pumping operation and thus need not be precisely controlled, to in
turn render unnecessary the use of liquid control means with
particularly precise operating characteristics and attendant high
cost. More specifically, it may be understood that the total
additional pressure drop provided by this reagent supply head
within the pressure container 52, and/or the variation in such
total additional pressure drop as would accompany even a relatively
large variation in reagent supply level, would be so small when
compared to the overall system pumping pressure as to have no
discernible effect upon reagent flow rate from the system, and this
may be understood to be especially valid for proposed pumping
systems wherein the total volume of the pressure container 52 is 50
ml. Too, and with specific regard to the pumping system form 44 of
FIG. 2, it may be understood that the discharge pressure of pump 48
is by no means critical since the said pump functions solely to
periodically replenish the reagent supply within pressure container
52.
In addition, it is believed clear that both system forms of this
invention function to completely eliminate the very significant
problems of hazardous, high pressure reagent leakage with resultant
loss of the requisite pumping system constant flow rate, and the
need for periodic system shutdown for reagent replenishment, which
problems are attendant the use of capped reagent containers in the
nature of those indicated at 18 and 20 in the depiction of a prior
art pressure-pumping system of FIG. 1. More specifically, since
pressure container 52 of the system of this invention is preferably
a factory-sealed container, it may be understood that reagent
leakage therefrom would be most improbable, while the periodic
replenishment of the reagent supply in the open reagent supply
container 46 may, of course, be conveniently periodically effected
without requiring system shutdown.
Although as described hereinabove, the liquid level control means
68 are set forth to be operative immediately in response to a
reagent level at a predetermined point in the pressure container
52, it may be understood that suitable timer means may, of course,
be operatively associated with said liquid level control means in
conventional manner to delay the operation thereof to a
predetermined extent and prevent "hunting."
Too, although the new and improved pressure-pumping system with
sealed pressure container of the invention has been disclosed for
use in the pumping of a reagent at constant flow rate to a blood
sample analysis system, it is believed clear that the system of the
invention is suitable for a wide variety of other and different
fluid pumping applications.
* * * * *