U.S. patent number 3,598,127 [Application Number 04/735,022] was granted by the patent office on 1971-08-10 for catheter having antibacterial substance therein provided with means permitting slow release of said substance.
Invention is credited to James G. Wepsic.
United States Patent |
3,598,127 |
Wepsic |
August 10, 1971 |
CATHETER HAVING ANTIBACTERIAL SUBSTANCE THEREIN PROVIDED WITH MEANS
PERMITTING SLOW RELEASE OF SAID SUBSTANCE
Abstract
A catheter has an inner tube of nonpermeable rubber formed with
V-shaped grooves extending along its length on the outside carrying
antibacterial agents permeable through polysiloxane rubber that
surrounds the V-shaped grooves. The antibacterial agents are
permeable through the polysiloxane rubber. Upon diffusion through
the polysiloxane layer the antibacterial agents help prevent
infection caused by bacteria moving up the tube toward the bladder
or other organ into which the catheter tube leads.
Inventors: |
Wepsic; James G. (Boston,
MA) |
Family
ID: |
24954026 |
Appl.
No.: |
04/735,022 |
Filed: |
June 6, 1968 |
Current U.S.
Class: |
604/265;
424/422 |
Current CPC
Class: |
A61M
25/00 (20130101); A61L 29/16 (20130101); A61M
2025/0056 (20130101); A61L 2300/404 (20130101) |
Current International
Class: |
A61L
29/16 (20060101); A61L 29/00 (20060101); A61M
25/00 (20060101); A61m 025/00 () |
Field of
Search: |
;128/348--351,325,343,214.4,260,DIG.21 ;3/1 ;138/118,137,138
;424/16,19--23 ;239/36,145 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
Other References
Dow Corning Bulletin Vol. 10, No. 1 January, 1968 pg. 1
128/Silicone DIG. .
Dow Corning Bulletin Vol. 8, No. 1, January 1966, pg. 1
128/Silicone DIG..
|
Primary Examiner: Truluck; Dalton L.
Claims
What I claim is:
1. A catheter containing an antibacterial substance for insertion
into the body comprising an elongate outer hollow tube permeable to
an antibacterial substance for slowly dispensing said antibacterial
substance therethrough after insertion into the body,
an elongate inner tube coextensive with and concentric within said
outer tube immediately adjacent thereto and made of material
substantially nonpermeable to said antibacterial substance,
and means containing said antibacterial substance positioned on the
outside of said inner tube immediately adjacent to the inside of
said outer tube.
2. A catheter tube in accordance with claim 1 wherein said outer
tube is made of polysiloxane rubber.
3. A catheter tube in accordance with claim 2 wherein said
antibacterial substance comprises a substance in the group
comprising neomycin, bacitracin, sulfa, mandelamine, zepheran,
hexachloraphine, and furadantoin.
4. A catheter tube in accordance with claim 1 wherein said outer
tube is made of polysiloxane rubber and said inner tube is made of
rubber nonpermeable to said antibacterial substance.
5. A catheter tube in accordance with claim 1 wherein said means
containing said antibacterial substance comprises at least one
longitudinal groove formed in said inner tube immediately adjacent
to said outer tube,
said antibacterial substance residing in said at least one
groove.
6. A catheter tube in accordance with claim 4 wherein said
antibacterial substance comprises a substance from the group
comprising neomycin, bacitracin, sulfa, mandelamine, zepheran,
hexachloraphine, and furadantoin.
Description
BACKGROUND OF THE INVENTION
The present invention relates in general to catheters and more
particularly concerns a novel catheter for reducing chance of
infection developing in an organ, such as the bladder, to which a
catheter tube leads from the outside of a patient.
It is known that bacterial count increases where a catheter enters
the body. Thus, the presence of a catheter, often essential during
the treatment of patients with certain conditions, increases the
chances of the patient developing an internal infection. One
possible approach toward reducing the chances of infection is to
continuously have an attendant sponge the area where the catheter
enters the body with an antibacterial agent. The shortage of
personnel in hospitals makes this approach impractical.
Accordingly, it is an important object of this invention to reduce
the chance of bacteria entering the body where a catheter is
inserted.
It is another object of the invention to achieve the preceding
object with a technique that requires negligible attention.
It is another object of the invention to achieve the preceding
object over relatively long periods of time.
It is another object of the invention to achieve the preceding
objects with a structure that is relatively easy and inexpensive to
fabricate and does not appreciably increase the outside diameter of
the catheter.
SUMMARY OF THE INVENTION
According to the invention, first means defines a hollow tube made
of material that is impermeable to bacterial agents, such as rubber
surrounded by means defining an outer layer of material permeable
to an antibacterial agent between the first and second means.
Typically, the second material is polysiloxane rubber. Typical
antibacterial substances suitable for use include neomycin,
bacitracin, sulfa, mandelamine, zepheran, hexachloraphine, and
furadantoin.
Other features, objects and advantages of the invention will become
apparent from the following specification when read in connection
with the accompanying drawing in which:
BRIEF DESCRIPTION OF THE DRAWING
FIG. 1 is a side view of a portion of a catheter according to the
invention with the outer layer in section; and
FIG. 2 is a sectional view through section 2-2 of FIG. 1.
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
With reference now to the drawing and more particularly FIGS. 1 and
2 thereof a catheter tube according to the invention comprises an
inner layer of nonpermeable rubber 11 that defines a hollow fluid
passage 12 through which fluids may be withdrawn from the patient.
Inner rubber tube 11 may be formed with a number of V-shaped
grooves 13--18, each filled with an antibacterial substance having
the property that the permeability of the substance through
polysiloxane rubber is much greater than through the nonpermeable
rubber of inner tube 11. Examples of such antibacterial substances
are neomycin, bacitracin, sulfa, mandelamine, zepheran,
hexachloraphine, and furadantoin. The antibacterial substance in
the V-shaped grooves is then sealed by an outer tube 21 of
polysiloxane rubber sold under the trade name Silastic.
The following tests have been conducted: First, to demonstrate that
antibacterial agents will go through layer 21 of polysiloxane
rubber, Silastic capsules constructed of hollow Silastic tubing
were sealed at each end to enclose the above-identified
antibacterial substances inside respective ones of the capsules
while control capsules were not filled with antibacterial
substances. The filled capsules along with the control capsules
were placed in separate tubes of saline. After a 7-day
equilibration, small samples of the fluid were placed on pieces of
filter paper. These pieces were then placed on blood-agar culture
plates which previously has been innoculated with bacteria
(bacteria obtained from urine of patients with infections). No
inhibition of bacterial growth occurred around the control discs
while a zone of inhibition appeared around the neomycin disc. These
tests demonstrate that antibacterial agent passed through the
Silastic membrane of the capsule in concentrations great enough
inhibit bacterial growth. Thus, apart from its utility as a
catheter, the invention has independent utility for slowly
dispensing antibacterial substance into a region adjacent the
outside of the Silastic tubing to inhibit the growth of
bacteria.
The second experiment was similar to the first except that thin
slices of the wall of the capsules were placed on the
bacteria-innoculated plates. Similar inhibition occurred indicating
that the Silastic membrane was able to hold the drug, much like a
sponge holds water, and then diffuse it from its surface.
There has been described a novel antibacterial substance dispenser,
in one form a catheter for reducing infection and/or inhibiting
bacteria growth over a long period of time without attention at
relatively low cost with a simple structure that negligibly, if at
all, increases the diameter of the catheter tube when embodied in
that form. It is evident that those skilled in the art may now make
numerous uses and modifications of and departures from the specific
embodiments described herein without departing from the inventive
concepts. For example, the V-shaped grooves could be omitted and
the catheter comprise a nonpermeable rubber inner tube surrounded
by a Silastic outer tube that is permeated with antibacterial agent
introduced by soaking such a tube in an antibacterial substance
until the Silastic outer tube absorbs enough substance to provide
the desired degree of bacterial inhibition over the desired length
of time. Other antibacterial substances and tube materials may be
employed so long as the relationship between the antibacterial
substance, inner tube and outer tube is such that the inner tube is
substantially nonpermeable to the antibacterial substance and the
outer tube is substantially permeable to the antibacterial
substance. Therefore, the invention is to be construed as embracing
each and every novel feature and novel combination of features
present in or possessed by the apparatus and techniques herein
disclosed and limited solely by the spirit and scope of the
appended claims.
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