U.S. patent number 3,590,815 [Application Number 04/789,551] was granted by the patent office on 1971-07-06 for portable mechanical ventricular assistance device.
Invention is credited to Peter Schiff.
United States Patent |
3,590,815 |
Schiff |
July 6, 1971 |
PORTABLE MECHANICAL VENTRICULAR ASSISTANCE DEVICE
Abstract
A portable mechanical ventricular assistance device including a
ventricular assistor cup designed to receive the ventricles of the
heart. The cup assembly is comprised of a rigid shell having a
configuration generally conforming to the surface configuration of
the heart ventricles and a flexible liner which is caused to
contract and expand about the heart ventricles to effect the
pumping action. The heart ventricles are retained within the cup by
a substantially sustained negative pressure while the pumping
action is produced by the application of alternating positive and
negative pressure pulses to the cup. Both the sustained negative
pressure and the positive and negative pressure pulses are
generated by a hand pump assembly which includes a manually
operable handle connected through a piston rod to a reciprocating
piston mounted within the cylinder of the pump. The piston
effectively divides the cylinder into two chambers, one of which is
coupled through a conduit to provide the sustained negative
pressure to the cup. The remaining chamber is coupled through a
second conduit to the ventricle assistor cup to provide for the
alternating positive and negative pressure pulses. Suitable
adjustable relief valves are provided in each of the conduits to
regulate the pressure levels and the positive or negative pressure
directed to the cup.
Inventors: |
Schiff; Peter (Lambertville,
NJ) |
Family
ID: |
25147955 |
Appl.
No.: |
04/789,551 |
Filed: |
January 7, 1969 |
Current U.S.
Class: |
601/153 |
Current CPC
Class: |
A61M
60/43 (20210101); A61M 60/268 (20210101); A61M
60/122 (20210101); A61M 60/40 (20210101) |
Current International
Class: |
A61M
1/10 (20060101); A61h 007/00 () |
Field of
Search: |
;128/24,24.2,64,67 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Trapp; L. W.
Claims
I claim:
1. A portable mechanical ventricular assistance device
comprising:
a ventricular assistor cup assembly including a rigid cup having an
interior configuration adapted to receive the ventricles of the
heart;
a flexible liner mounted within said cup having a first opening for
receiving the ventricles of the heart; a first port positioned at
the apex of the cup opposite the first opening, and a second port
positioned intermediate the first opening and the first port;
said flexible liner being sealed to the interior surface of said
cup along a first marginal portion adjacent to and surrounding said
first opening and along a second marginal portion adjacent to and
surrounding said first opening and along a second marginal portion
adjacent to and surrounding said first ports;
A first-sustained negative pressure conduit having a first end
coupled to said first port;
a second pulsed positive and negative pressure line having a first
end coupled to said second port;
reciprocating pump means having first and second outputs each
capable of developing positive and negative pressure pulses during
reciprocation of said pump;
said first and second outputs being respectively coupled to the
second ends of said first and second conduits;
valve means coupled in said first conduit for coupling only
negative pressure pulses to said first port.
2. The device of claim 1 further comprising first and second relief
valve means connected to said second conduit for limiting the
maximum positive and negative pressure pulses delivered to said
second port.
3. The device of claim 1 further comprising first relief valve
means coupled to said first conduit for limiting the negative
pressure pulses delivered to said first port to a predetermined
threshold level; and second one-way valve means for releasing
positive pressure pulses injected into said first conduit to the
atmosphere.
4. The device of claim 1 further comprising a liquid trap coupled
between said first conduit and said first port for preventing the
flow of any liquid toward said pump means.
5. The device of claim 1 wherein said pump means is comprised of a
cylinder containing a reciprocally mounted double-acting piston
dividing said cylinder into first and second chambers;
said first and second outputs communicating respectively with said
first and second chambers.
6. The device of claim 1 wherein said pump means is comprised of a
cylinder having a collapsible bellows-type wall;
said first and second outputs communicating with the interior of
said cylinder.
7. The device of claim 1 wherein said pump means is comprised of a
cylinder having a collapsible bellows-type wall;
a barrier wall in said cylinder dividing said cylinder into first
and second chambers;
said first and second outputs respectively communicating with the
interiors of said first and second chambers.
Description
The present invention relates to circulatory sustaining devices,
and more particularly to a novel portable mechanical ventricular
assistance device for sustaining the pumping action of a heart.
Numerous devices have been developed to either sustain the
circulatory function of a patient, or, alternatively, to sustain
the pumping action of a heart. All such devices may be classified
into two basic categories; namely, bypass systems and indirect
pumping systems. Devices falling into the category of bypass
systems are designed to bypass the flow of blood from the heart and
to maintain the pumping action otherwise performed by the heart
through mechanical or electromechanical devices. Devices falling
into the indirect pumping category are designed to assist the heart
in the performance of its pumping function. The present invention
falls into the latter category.
Devices classified in the former category are usually quite complex
in nature and rather large in size so as to limit their use to
operating rooms and effectively prohibit their use as a portable
device.
Devices developed up to the present which are classified in the
latter category are normally comprised of motor means for
developing the necessary pressure or vacuum levels and are further
comprised of electromechanical means for regulating the flow of the
necessary pressure levels to the heart pump. Such equipment is
likewise heavy in nature and large in size so as to prohibit its
use as a truly portable device.
Devices of the indirect type have been used with great success in
the fields of heart and organ transplants. When a potential cadaver
(donor), whose organ or organs are available for transplant
purposes, is to receive mechanical ventricular assitance, the
assistor system is rushed to him for the purpose of sustaining the
heart pumping action. Under present-day techniques and with
present-day device, in order to transport the cadaver to the
operating room, the assistor is temporarily disconnected, due to
the fact that it is too bulky and requires too much electrical
power to perform the circulatory function during the time in which
the donor is being moved. The period during which the assistor
device is disconnected may thus have a harmful effect upon the
organ or organs to be transplanted.
The device of the present invention, which is designed to be truly
portable and to be simple to connect and operate, is extremely
advantageous for use during the period of time in which the donor
is being moved from one location to another, as well as for other
emergency situations.
The present invention is comprised of a ventricular assistor cup
assembly having a rigid outer shell of a configuration
substantially conforming to the surface configuration of the heart
ventricles. The cup contains a flexible liner capable of expanding
and contracting about the heart ventricles to perform assistive
pumping action.
The cup is provided with a first large opening for receiving the
heart ventricles. A second opening provided at the apex of the cup
receives the sustained negative pressure necessary to retain the
ventricles within the cup assembly. A third opening provided in the
cup along the surface thereof and intermediate the first and second
openings is designed to receive the pulsatile pressures of
alternating positive and negative pressure pulses which cause the
contraction and expansion of the flexible liner about the heart
ventricles.
All of the above-mentioned pressures are provided through the use
of a single portable pump assembly having a first handle adapted to
receive and position the operator's foot for holding the pump
steady during operation. A second manually operable handle is
provided for driving a reciprocating piston mounted within the pump
cylinder. The piston effectively divides the pump cylinder into
first and second chambers, each of which is coupled through an
associated conduit to the sustained negative pressure opening and
the pulsatile pressure opening, respectively. Adjustable relief
valves are provided in the pulsatile pressure conduit to control
the pressure (or vacuum) level of the pulse injected into the
pulsatile pressure conduit. Similar adjustable relief vales are
provided in the sustained negative pressure conduit for controlling
the level of negative pressure and for bypassing positive pressure
pulses from reaching the assistor cup assembly. An additional
one-way valve assembly is provided in the sustained negative
pressure conduit to prevent positive pressure pulses from reaching
the assistor cup assembly and to maintain the negative pressure
developed in the cup during the application of positive pressure
pulses to the sustained negative pressure line.
The simplicity and portability of the system make it extremely
advantageous for use in a variety of applications, especially those
of an emergency nature. The portable system described herein may be
easily and rapidly substituted for conventional assemblies in
moving donors from one location to another, or may be used in
emergency situations to sustain the circulatory function until such
time as the patient is moved to a hospital.
It is, therefore, one object of the present invention to provide a
nevel portable mechanical ventricular assistance device.
Still another object of the present invention is to provide a novel
pump assembly for use with ventricular assistor cup assemblies, and
the like, which is capable of developing a sustained pressure at a
first output thereof and which is capable of developing a pulsatile
pressure of alternating positive and negative pressure pulses at
the second output thereof.
Yet a further object of the present invention is to provide a novel
pump assembly for use with ventricular assistor cup assemblies, and
the like, which is capable of developing a sustained pressure at a
first output thereof and which is capable of developing a pulsatile
pressure of alternating positive and negative pressure pulses at
the second output thereof, whereby the pressure levels of the
sustained and alternating pressure pulses are made adjustable
through the use of adjustable valve means associated with each of
the hand pump outputs.
These as well as other objects of the present invention will become
apparent when reading the accompanying description and drawings in
which:
FIG. 1 shows a diagrammatic view partially sectionalized of the
pump assembly of the present invention as applied to a ventricular
assistor cup assembly.
FIGS. 2a and 2b are schematic diagrams showing alternative
embodiments for the pump portions of the assembly.
The device of the present invention is comprised of a hand pump
assembly 10 for use in operating a ventricular assistor cup
assembly 20.
The ventricular assistor cup assembly is described in greater
detail in copending application (M-6019) Ser. No. 785,652, filed
Dec. 20, 1968 and assigned to the assignee of the present
invention, which description is incorporated herein by reference
thereto. For this reason, a detailed description of the assistor
cup assembly will be omitted from this application for purposes of
simplicity. For purposes of understanding the present invention it
is sufficient to understand that the assistor cup assembly 20 is
comprised of a rigid cup 21 having a first large opening 22 for
receiving the ventricles of the heart; a second opening 23 arranged
at the apex of the cup for receiving a sustained negative pressure
line; and a third opening 24 for receiving a pulsatile pressure
line. The interior of the cup is provided with a flexible liner 25
secured at 26 and 27 by suitable adhesive means, for example, near
the apex opening 23 and the large opening 22, respectively. The
liner 25 is mounted within and sealed to cup 21 in such a manner as
to form a hollow interior space whose only opening is opening 24
which receives the pulsatile pressure line. The injection of
positive pressure into this hollow interior space causes the
contraction of liner 25 which, in turn, contracts the ventricles of
the heart embraced by the liner. Injection of a negative pressure
pulse returns the liner 25 substantially to the position shown in
FIG. 1 to allow for expansion of the heart ventricles. This
operation is continuously repeated to assist the heart in
sustaining its pumping function. The apex opening 23 receives the
substantially sustained negative pressure to retain the ventricles
within the cup throughout the entire pumping operation and
independently of the pulsatile pressure applied to opening 24.
The portable pump assembly 10 for use with the ventricular assistor
cup assembly 20 is comprised of a cylinder 13 having secured at one
exterior end thereof a handle 12. The cylinder contains a
reciprocating piston 14 of the double-acting piston type. Piston 14
is coupled through a piston rod 15 to an exterior mounted handle
11. The opening provided for piston rod 15 at the upper end of
cylinder 13 may be provided with a suitable seal such as an O-ring
16 to prevent the escape of compressed air from the cylinder.
Piston 14 effectively divides the cylinder into first and second
piston chambers 17 and 18.
Upper chamber 17 is provided with an opening 18 for receiving a
sustained negative pressure conduit 31 which couples chamber 17
through a liquid trap 32 and conduit 33 to the opening 23 provided
in the apex of assistor cup 21.
Lower chamber 18 is provided with an opening 34 for receiving a
conduit 35 coupling the chamber to the pulsatile pressure opening
24 in cup 21.
Suitable valve means are provided in the conduits connecting the
assistor cup to the pump assembly for regulating the pressure level
and pressure direction of pressure pulses injected into each of the
lines. The conduit 31 is provided with a first one-way valve
assembly 36 which may, for example, be comprised of first and
second spaced annular rings 37 and 38 arranged in the interior of
conduit 31. A spherical member or ball 39 is normally urged against
annular-shaped ring 38 by a bias spring 40 secured at one end to
annular disc 37 and having its opposite end bearing against ball
39.
Similar one-way valve assemblies 41 and 46 are arranged at spaced
intervals along conduit 31 to perform functions which will be more
fully described.
In a like manner, positive and negative relief valve assemblies 53
and 58 are arranged at spaced intervals along the surface of
conduit 35 for functions to be more fully described.
The upper piston chamber 17 provides the sustained negative
pressure for the ventricular assistor cup which is obtained on the
"down" stroke of piston 14. Let it be assumed that the piston 14 is
positioned near the top of cylinder 13 and is moved vertically
downward in the direction shown by arrow A. A negative pressure or
vacuum is developed in chamber 17. Due to the pressure differential
across the right-hand and left-hand sides of one-way valve 36, ball
39 is caused to unseal the opening in ring 38, allowing this
negative pressure (i.e., vacuum) state to communicate with the apex
opening 23 in cup 21.
The relief valve assembly 46 is adjusted to cause ball 49 to unseal
the opening in ring 50 when the negative pressure in conduit 31 is
greater than a predetermined threshold level. The relief valve 46
thus automatically controls the maximum negative pressure applied
to the assistor cup. The maximum negative pressure may be made
adjustable by providing suitable means for adjusting the bias
applied to ball 49 by bias spring 48. A suitable filter member 51
is secured between ring 50 and ring 52 to filter out dust or any
other unwanted particles carried by the air entering into the
system when valve 46 opens.
The negative pressure applied to the assistor cup is sustained
until the piston 14 reaches the bottom of its stroke. On the "up"
stroke, i.e., when the piston moves from the bottom of its stroke
upward in the direction shown by arrow B, one-way valve 36 is
sealed to prevent positive pressure from passing the valve and
communicating with the assistor cup. The sealing of valve 36 during
the entire "up" stroke also acts to maintain the negative pressure
in assistor cup 20 until the next "down" stroke. One-way valve 41
releases the pressure being developed in upper chamber 17 during
the upward stroke by having its ball 42 moved downwardly against
the force of bias spring 43 to unseal the opening in annular-shaped
ring 44. The negative pressure developed in conduit 31 during a
"down" stroke of piston 14 is thus sustained during the"up" stroke
of piston 14. The liquid trap 32 traps any liquid passing from cup
assembly 20 toward the sustained negative conduit 31.
Lower piston chamber 18 operates in much the same manner as upper
chamber 17 except that both positive and negative pulsatile
pressures are applied to cup opening 24 by line 35. For this
reason, conduit 35 is provided with two relief valves, one for
positive pressure 53 and one for negative pressure 58.
During an "up" stroke of piston 14, i.e., when piston 14 moves in
the direction of arrow B, a negative pressure or vacuum is
developed in conduit 35 and is coupled to cup opening 24, causing
the flexible liner 25 to move from a contracted position to the
relaxed position shown in dotted line fashion in FIG. 1. If this
negative pressure exceeds a predetermined threshold level, the ball
59 of relief valve 58 will move downward against the force of
biasing spring 60 to unseal the opening in ring 61, thereby
automatically controlling the maximum negative pressure which may
be developed in conduit 35.
During a "down" stroke of position 14, i.e., when the piston moves
from its uppermost position downward in the direction shown by
arrow A, a positive pressure is developed in lower piston chamber
18, causing a positive pressure pulse to be injected into opening
24 of the ventricular cup assembly. This causes the flexible liner
25 to contract the ventricles of the heart encircled by the liner.
If the positive pressure injected into conduit 35 exceeds a
predetermined threshold level, ball 54 of relief valve 53 will be
caused to move upwardly against the force of bias spring 55 to
relieve the excess positive pressure developed in conduit 35. The
relief valves 53 and 58 thereby automatically control the positive
and negative pressure pulses delivered to the ventricular cup
assembly 20. Suitable adjustable means may be provided in both the
positive and negative relief valve assemblies 53 and 58,
respectively, to adjust the force of the biasing springs an thereby
calibrate the maximum positive and negative pressure levels. The
relief valves further limit the pressures as necessary for full
strokes, regardless of the ventricular cup-pumping displacement.
The negative relief valve assembly is provided with a filter 63 to
filter out any unwanted particles or other material which may be in
the atmosphere against entering into the system with the air
entering through the relief valve assembly 58 whenever it is caused
to open.
The pump may be operated by one person in a variety of ways. One
preferred manner of operating the pump is to place one foot through
the opening formed by stationary handle 12 and operating the
movable handle 11 in a reciprocating fashion by grasping and moving
handle 11 with either one or both hands. Alternatively, each of the
handles 11 and 12 may be grasped by one hand, and the pump may be
operated in a reciprocating fashion in this manner. Obviously, if
desired, two persons may operate the pump, but the simplicity of
operation and size of the pump does not necessitate such
alternative operation.
FIGS. 2a and 2b show alternative arrangements for the pump assembly
of FIG. 1. Considering FIG. 2a, the pump arrangement 10' is a
bellows pump selectively expandable and contractable due to its
bellows arrangement 70. The interior of the bellows arrangement is
divided by a barrier wall 71 forming upper and lower chambers are
coupled to conduits 31 and 35 of FIG. 1 in the same manner as the
pump assembly shown in FIG. 1. Operation of the pump assembly of
FIG. 2a may be performed in the same manner as the device shown in
FIG. 1 by grasping the handles 11 and 12 and urging them
alternatively together and apart to create the positive and
negative pressure phases occurring during each reciprocating
cycle.
FIG.2b shows an alternative pump assembly 10" having a bellows
assembly 70 comprised of a single internal chamber 72 having
openings 73 and 74 for communicating with the conduits 31 and 35 of
FIG. 1. In operation, the handles 11 and 12 are alternately urged
toward one another and apart from one another to create positive
and negative pressures within the internal chamber 72 to provide
the positive and negative pressure signals in conduit 35 while
providing only a sustained negative pressure signal in conduit
31.
When using the double-acting piston type of FIG. 1, it is possible
to develop sustained negative pressure in conduit 31 during both
the "up" and "down" stroke by coupling an additional conduit near
the bottom of cylinder 13 which is provided with valve assemblies
substantially identical to the assemblies 36, 41 and 46. This
additional conduit may be coupled into conduit 31 as shown by
dotted line 31'. Thus, each stroke, whether "up" or "down", of the
piston will contribute to sustaining the negative pressure in the
assistor cup assembly. This alternative embodiment may be used in
cases where the pump assembly is capable of providing a sufficient
negative pressure pulse for operating the flexible liner 25 and for
simultaneously sustaining the negative pressure maintained at the
opening 23 of the assistor cup assembly.
It can be seen from the foregoing description that the present
invention provides a novel portable pump assembly especially
advantageous for use with ventricular assistor cup assemblies to
maintain and sustain the pumping operation of the heart by
providing an independent sustained negative pressure (vacuum) at
one output thereof and by providing alternating positive and
negative pressure pulses at a second output thereof for performing
the functions necessary in the operation of such a ventricular cup
assembly. It should be obvious that various modifications may be
made in the pump assembly without departing from the scope of the
invention. For example, a one-way valve of the type shown in
conduit 31 may be provided in conduit 35 for providing sustained
negative pressures in each of the outputs developed by the pump for
such applications in which negative pressures of this type might be
required. The negative pressure values obtained may be adjusted to
be of different values through simple adjustment of the valves. As
a further modification, the one-way valves provided within each of
the conduits 31 and 35 may be reversed in direction of operation so
as to provide a first output for generating a positive sustained
pressure and a second output for generating a sustained negative
pressure. As still another alternative, the one-way valve assembly
36 provided in conduit 31 may be omitted to provide a pump having
two outputs, each of which is capable of providing alternating
positive and negative pressures wherein each of the positive and
negative pressures developed by each of the outputs may be set at
any predetermined threshold levels, depending upon the needs of the
user. In addition, the single cylinder having a double-acting
piston may be replaced by two cylinders each having a reciprocating
piston. The cylinders may be placed side-by-side and arranged to be
reciprocated by a single operating handle.
The assemblies of the figures may be operated by mechanical or
electromechanical means, if desired. For example, a motor M may
drive a reciprocating arm A through shaft S which is coupled to
handle 11 of FIG. 1. A rotary to reciprocating motion device D
converts the rotation of the shaft S into reciprocating movement.
Alternatively, a relay R having a reciprocating armature RA may be
alternately energized and deenergized to reciprocate up and down
(for example) to impart reciprocating movement to the piston rod 15
(for example). The down stroke may be imparted by energizing the
relay driving its armature downward. Deenergization of relay R will
cause the upstroke under control of a biassing spring (not
shown).
Although this invention has been described with respect to
particular embodiments, it should be understood that many
variations and modifications will now be obvious to those skilled
in the art, and, therefore, the scope of this invention is limited
not by the specific disclosure herein, but only by the appended
claims.
* * * * *