U.S. patent number 3,564,256 [Application Number 04/642,968] was granted by the patent office on 1971-02-16 for radioisotope generator of the mother-daughter type having quick-detachable members.
This patent grant is currently assigned to U.S. Philips Corporation. Invention is credited to Jan Jacob Arlman, Dirk Nonhebel.
United States Patent |
3,564,256 |
Arlman , et al. |
February 16, 1971 |
**Please see images for:
( Certificate of Correction ) ** |
RADIOISOTOPE GENERATOR OF THE MOTHER-DAUGHTER TYPE HAVING
QUICK-DETACHABLE MEMBERS
Abstract
A device is disclosed for obtaining fluids containing
radioactive constituents particularly suitable for medical
purposes. The device includes a holder for a substance having
radioactive constituents and which is providing at the upper and
lower ends with a portion of a quick-coupling member. In operation
a vessel for a flushing liquid is connected with the upper coupling
portion and the vessel for the fluid to be collected is connected
with the lower coupling member portion to facilitate washing of the
holder and collection of the fluid from the holder while avoiding
contamination of the fluid in the holder.
Inventors: |
Arlman; Jan Jacob (Amsterdam,
NL), Nonhebel; Dirk (Amsterdam, NL) |
Assignee: |
U.S. Philips Corporation (New
York, NY)
|
Family
ID: |
19796780 |
Appl.
No.: |
04/642,968 |
Filed: |
June 1, 1967 |
Foreign Application Priority Data
Current U.S.
Class: |
250/432R;
250/432PD; 976/DIG.374 |
Current CPC
Class: |
A61M
5/00 (20130101); F16L 29/005 (20130101); G21G
4/08 (20130101); A61J 1/06 (20130101); G21F
7/068 (20130101); G21G 1/0005 (20130101); A61J
1/2096 (20130101); A61J 1/2013 (20150501); A61J
1/2086 (20150501); A61J 1/201 (20150501); A61J
1/2065 (20150501) |
Current International
Class: |
A61J
1/06 (20060101); G21F 7/06 (20060101); G21G
4/08 (20060101); A61M 5/00 (20060101); F16L
29/00 (20060101); G21F 7/00 (20060101); G21G
4/00 (20060101); A61J 1/00 (20060101); G21h
005/00 () |
Field of
Search: |
;250/106,T,108 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Borchelt; Archie R.
Claims
We claim:
1. A device for obtaining fluids containing radioactive
constituents particularly suitable for medical purposes comprising
a detachable holder closed at its upper and lower end by a
pierceable wall, a pair of interfitting box-shaped members
surrounding said holder, each of said box-shaped members having a
prolongation which is provided with a first part of a
quick-coupling means, said first part for each prolongation
carrying a hollow needle which protrudes into said pierceable wall
during operation of said device, a vessel for containing washing
fluid having a second part of said quick-coupling means to be
connected with the first part of said quick-coupling means at the
upper side of the holder, and a vessel for the fluid to be
collected having a second part of said quick-coupling means at the
lower side of the holder.
2. A device as claimed in claim 1 in which each vessel has a
substantially cylindrical shape and accommodates a moveable
piston.
3. A device as claimed in claim 2, in which characterized in that
the vessel for the washing fluid and the vessel for collecting the
product are formed each by the body of a syringe in which a piston
is adapted to move.
Description
The invention relates to a device comprising a detachable holder
for a substance having radioactive constituents, into which holder,
in operation, a washing fluid is introduced at the upper end, while
a fluid containing radioactive constituents, particularly suitable
for medical purposes is obtained from the lower end of said holder
and collected in a vessel.
In such a device the holder may contain a radioactive mother
substance bound, for example, to an ion exchanger, for instance
molybdenum-99 or germanium-68, which decays with time by radiation
into a radioactive daughter substance having a shorter half-value
period than the mother substance, for example, Technicium-99m or
gallium-68. These daughter substances suitable for various medical
purposes. They may be injected as liquid suspensions into the blood
vessels of the human body, where they provide by their radiation
measurable data about physical procedures and conditions of body
organs.
By washing the contents of the holder with a flush which carries
along the daughter substance, the desired product of the device,
formed by a fluid having the daughter substance is obtained.
A known device of this kind comprises a holder with the mother
substance, also termed the generator, which holder is open at the
bottom and whose closure at the top is removed for introducing the
washing fluid. Beneath the holder an open vessel is arranged. In
operation the holder and the vessel of that device are usually
screened at least partly, for example by a lead jacket. During the
washing operation, that is to say, when the flush is poured in and
the product is collected, the upper end and the lower end of the
holder and also the collecting vessel remain open. This known
device has the advantage that it allows quick manipulation, which
is important for avoiding a noxious effect of the radiation on the
operator or persons standing by. This advantage is particularly
appreciated in preparing the device for operation, for example,
when the generator is taken out of its packing and introduced into
the device and during the washing operation itself.
The product of the device, the fluid containing the
daughter-substance or eluate, has to fulfill, because of its
medical use, the requirements of being sterile and pyrogen-free.
The known device has the disadvantage that it cannot fulfill this
requirement without the need for further steps. Since the holder
and the collecting vessel are open during the washing operation,
infecting substances are freely accessible to the product. It is
therefore necessary to subject the product of this known device to
a sterilizing treatment before use. This may be particularly
disadvantageous, when the half-value period of the radioactive
product is only little longer than the period of time required for
sterilization. It is even not possible to use for medical purposes
the radioactivity of the eluates obtained by the known device, if
these eluates have a half-value period approximately equal to or
shorter than the required period of sterilization.
The invention has for its object to provide a device for obtaining
fluids containing radioactive constituents particularly suitable
for medical purposes, by which the disadvantages of the known
device described can be avoided and the said advantages are
maintained. A device of the kind set forth according to the
invention is characterized in that the holder is provided at the
upper end and at the lower end with a portion of a quick-coupling
member, while in operation a vessel for the flushing liquid is
connected with the upper coupling member portion and the vessel for
the fluid to be collected is connected with the lower coupling
member portion.
By employing quick coupling members the advantage of easy and rapid
operation of the device according to the invention is maintained. A
further advantage of the device according to the invention consists
in that during washing the holder and the vessels communicate with
each other, so that the fluids and the contents of the holder are
not accessible for particles from the environments. This means
that, it being assumed that the conventional steps are taken such
as the use of presterilized, pyrogen-free washing fluid, vessels
and coupling members, the device can provide from a sterile,
pyrogen-free generator a sterile and pyrogen-free product directly
suitable for medical use. Subsequent sterilization of the product
may be dispensed with. Even daughter substances having a very short
half-value period may be employed.
One embodiment of the device according to the invention is
characterized in that a portion of the holder coupling member is
formed by a pierceable wall portion of the holder and a coupling
portion that can be connected herewith is formed by a hollow
needle. The pierceable wall portion may be formed by a rubber plug,
arranged on the holder, for example, of glass and sealed at the
edge by a flanged capsule. The needle may be an injection needle.
These parts are known from the medical apparatus technology. By
said parts a quick-coupling can be established in a very simple
manner between the holder and a vessel. Other kinds of
quick-coupling members may, of course, be employed, such as those
known for the detachable connection of an injection needle with the
body of an injection syringe.
The possibility of ready manipulation, especially of the
radioactive parts of the device is improved in a further embodiment
which is characterized in that a coupling portion adapted to be
connected with a coupling portion of the holder is fastened to the
end wall of an approximately box-shaped element, which is open at
one end and surrounds the holder at least partly with small
clearance in the operation of the device. The box-shaped element,
previously sterilized in the conventional manner, may be fastened
in or inserted into the device (for example through an opening of a
lead jacket), after which the generator can be simply inserted into
this element, while at the same time the connection of the coupling
concerned can be rapidly established. The device according to the
invention may be furthermore characterized in that in operation the
holder is surrounded by two box-shaped elements, which surround the
holder with a slight amount of clearance and fit one in the other
and, if any, in a screening jacket of the device, each element
having a coupling portion adapted to be connected with a coupling
portion of the holder. It is thus possible to connect the two sides
of the holder rapidly with the elements, while the second
box-shaped element is slipped onto the first element like a
lid.
An advantageous embodiment of the device according to the invention
is characterized in that a connection between a vessel and a
coupling portion adapted to be connected with a holder coupling
includes a further detachable coupling member, a first portion of
which is fastened to the vessel and a second portion to the
coupling portion adapted to be connected with the holder. It is
thus possible to handle a vessel and a box-shaped element as
separate parts. They may therefore be sterilized separately, but
the particular advantage of this embodiment resides in that the
sterile quick connections of the holder once established need not
be interrupted for the whole lifetime of the mother substance.
During this period of time, in which the generator may be
repeatedly washed, the box-shaped elements, if provided, remain in
the device, while the vessels for the washing fluid and the product
can be replaced according to need after each washing operation or
more frequently.
A further connection between a quick-coupling member for the holder
and a vessel may be established by means of a readily sterilizable
coupling member, preferably a quick-coupling member known from the
medical instrument technology. In a further advantageous embodiment
the device according to the invention is characterized in that a
coupling portion fastened to a vessel is formed by a pierceable
wall portion of the vessel, while the coupling portion to be
connected therewith is formed by a hollow needle. For withdrawing
the air from the vessel a second hollow needle may be pierced
through said wall portion of the vessel.
In a further advantageous device embodying the invention the vessel
need not be freed of air. This embodiment is characterized in that
the vessel is substantially cylindrical and accommodates a movable
piston. When using such a vessel both beneath and above the holder,
that is to say both for the washing fluid and for the product, the
vessel and the holder of the resultant device form a closed system,
into which no air need be introduced above the washing fluid and
from which no air need be removed from the collecting vessel. This
device approaches therefore very closely the ideal of a perfectly
sterile product.
A vessel with a piston may be formed by the body of a medical
syringe.
The invention will be described more fully with reference to the
drawing, which shows a device according to the invention in a
diagrammatic sectional view.
In the position shown the device is provided with the holder having
the substance containing radioactive constituents and the vessels
for the washing fluid and the product to be collected.
The holder 1 of the device may contain a radioactive mother
substance, such as molybdenum-99 or germanium-68, bound to an ion
exchanger, formed for example by given resins or aluminum oxide.
The binder and the mother substance are designated by 2; they are
provided in the holder 1 above a filter 3. The holder 1, which is
cylindrical in this embodiment, may be made of glass and has an
opening at the upper and the lower ends, closed by rubber plugs 4.
The edges of the plugs 4 are furthermore sealed by flanged capsules
5, which leave the center of the plugs 4 uncovered.
In the position shown the holder 1 is surrounded by two box-shaped
elements 6 fitting one in the other and around the holder with a
small clearance. The cylindrical elements 6 are open at one end and
have a prolongation 8 at the end walls 7 at the opposite ends. The
ends of the prolongations 8 have a portion 9 of a mechanical
quick-coupling member which by means of a screw thread is
detachable. The portions 9 form at the same time the settings for
the hollow needles 10, which may be soldered in said portions
9.
The vessels 11 and 12 comprise each a cylindrical body 13, for
example, of glass, to which rings 14 are cemented. The lids 15 join
the rings 14. The other ends of the vessels 11 and 12 are closed by
lids 16. Through openings in the lids 15 emerge the piston rods 17
of the pistons 18. The lids 16 comprise the portions 19 of a
mechanical quick-coupling member, which are attached in the
position shown to said portions 9 of said coupling member. The
vessel 11 contains a washing fluid 20, which may be a physiological
salt solution.
The holder 1 and the elements 6 are largely surrounded by a
screening jacket 21, for example, of lead. Through the screening
jacket 21 bolts 22 are taken for clamping the elements 6 in the
jacket 21. The jacket 21 is closed at the upper end by lids 23, for
example, of lead. The vessel 12 for collecting the radioactive
fluid is surrounded by a screening formed by a cylindrical jacket
24, cut into halves in the longitudinal direction, these halves
being held in place by a tube 25, slipped around them and closed by
a lid 26. The jacket 24, the tube 25 and the lid 26 may also be
made of lead. The vessels 11 and 12 may be formed by conventional
medical syringes of adequate capacities, for example 30 or 50
mls.
The screening jacket 21 bears on a support 27, having an upper
plate 28, columns 29 and a base plate 30.
The device is operated as follows. The holder, closed by the plugs
5, is introduced into the sterilized lower elements 6, arranged
previously in the jacket 21, while the lower plug is pierced by the
lower needle 10. The lower coupling portion 9 may be closed by a
suitable plug. The upper element 6 with its needle 10 and the
coupling portion 9 is arranged in place, after which the lids 23
are arranged. The two plugs 5 of the holder 1 are then pierced by
the needles 10. Also the upper coupling portion 9 may be closed by
a fitting plug. The elements 6 can be fixed in place by means of
the bolts 22.
Then after removal of the closing plugs from the coupling portions
9 and/or 19, if any, the vessels 12 and 11 are connected; the
vessel 12 in the empty state while the piston 18 of this vessel is
in the upper position and the vessel 11, filled with the washing
fluid 20 beneath the piston 18 of this vessel. By force of
gravitation the washing operation starts. If desired, a slight
pressure may be exerted on the upper piston rod 17, for example, by
means of a weight. Particularly the piston 18 of the vessel 11 has
to be readily movable in the cylinder of this vessel.
The fluid 20 flows through the holder 1, while the radioactive
mother substance remains bound to the binder, but the radioactive
eluate is carried along downwards through the filter 3 to the
collecting vessel 12.
The vessels 11 and 12 and the holder 1 form, during the washing
operation, a closed system into which no air is allowed to enter
and from which no air need be withdrawn. In this manner such a
sterile, pyrogen-free fluid with a radioactive daughter substance
is collected in the vessel 12 that subsequent sterilization is no
longer required.
In the device shown, embodying the invention holders 31 with two
quick-coupling portions 32 are fastened to the upper plate 28 of
the stand 27. With the portions 32 may be connected for example at
one end a filled vessel 12 and at the other end syringe bodies of
smaller volumes to be filled in order of succession from said
vessel.
The drawing shows diagrammatically only one embodiment of the
invention. As a matter of course, many other embodiments of the
invention differing from the construction and details of the
embodiment shown are possible.
* * * * *