U.S. patent number 3,557,795 [Application Number 04/738,146] was granted by the patent office on 1971-01-26 for suture provided with wound healing coating.
This patent grant is currently assigned to Edward Weck & Company, Inc.. Invention is credited to Winfred Hirsch.
United States Patent |
3,557,795 |
Hirsch |
January 26, 1971 |
SUTURE PROVIDED WITH WOUND HEALING COATING
Abstract
Sutures coated with a wound-healing, nontoxic metal, such as
aluminum or magnesium, are described as are methods for coating
sutures with such material.
Inventors: |
Hirsch; Winfred (Plainview,
NY) |
Assignee: |
Edward Weck & Company, Inc.
(Long Island City, NY)
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Family
ID: |
24966766 |
Appl.
No.: |
04/738,146 |
Filed: |
June 19, 1968 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
Issue Date |
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531768 |
Mar 4, 1966 |
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Current U.S.
Class: |
606/228; 428/375;
623/66.1; 428/332; 427/2.31 |
Current CPC
Class: |
A61L
17/005 (20130101); A61B 17/06166 (20130101); A61L
2300/102 (20130101); A61L 2300/412 (20130101); A61L
2300/606 (20130101); Y10T 428/2933 (20150115); Y10T
428/26 (20150115) |
Current International
Class: |
A61L
17/00 (20060101); A61B 17/06 (20060101); A61l
017/00 () |
Field of
Search: |
;128/335.5 ;161/175,176
;117/31,160,130.8 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
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375,482 |
|
May 1923 |
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DT |
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231,037 |
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Mar 1925 |
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GB |
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Other References
Kraissl - Surgery Gyne. & Obstet. - May 1936 pp. 417--423
128-335.5.
|
Primary Examiner: Truluck; Dalton L.
Parent Case Text
CROSS REFERENCES
This is a continuation-in-part of application Ser. No. 531,768
filed Mar. 4, 1966, for SUTURES AND LIGATURES ADAPTED FOR THE
ACCELERATION OF WOUND HEALING, and now abandoned.
Claims
I claim:
1. A surgical suture useful for accelerating the healing of wounds
by beneficial fibrotic reaction with the tissues surrounding such
wounds, said suture comprising:
an elongated core of surgical suture material; and
a coating on said core of a different material, said coating
extending over a substantial portion of the surface of said core,
said coating material being selected from the group consisting of
substantially pure aluminum and substantially pure magnesium.
2. A suture material according to claim 1 wherein said coating has
a thickness of between about 6 and 40 microns.
3. A suture material according to claim 2 wherein said coating
comprises aluminum.
4. A suture material according to claim 2 wherein said coating
comprises magnesium.
5. A suture component according to claim 3 wherein said suture
component comprises a nonabsorbable suture.
6. A suture material according to claim 5 wherein said
nonabsorbable suture component comprises Dacron and said aluminum
coating has a thickness of between 10 to 20 microns.
7. A suture material according to claim 2 wherein said suture
component comprises an absorbable suture and said coating comprises
aluminum.
8. A suture material according to claim 5 wherein said
nonabsorbable suture component comprises stainless steel.
9. A surgical material for use in a patient as ligatures and as
sutures for closing wounds, said surgical material comprising:
an elongated core of surgical suture material; and
a coating on said core of a different material, said coating
extending over a substantial portion of the surface of said core,
said coating material being selected from the group consisting of
substantially pure aluminum and substantially pure magnesium; said
coating being adapted to beneficially chemically react with the
tissues in the vicinity of said surgical material, said coating
being of such thickness as to increase the rate of fibrosis in said
tissues at a controlled rate, said coating being dissipated by said
chemical reaction and the residual fibrotic reaction due to said
coating materials ceasing when said coating has been completely
dissipated.
10. The combination according to claim 9 wherein said coating
comprises pure aluminum.
11. The combination according to claim 10 wherein said suture
component comprises a nonabsorbable material which can be left as a
supporting element for the wound tissues after said coating has
been completely dissipated.
12. The combination according to claim 11 wherein said aluminum
coating has a thickness of between about 6 to 40 microns.
13. A suture component and coating according to claim 7 wherein
said suture component is resorbable in the wound and said coating
protects said component against resorption until said coating has
been dissipated.
14. A suture component and coating according to claim 11 wherein
said coating comprises pure aluminum between about 10 to 20 microns
in thickness.
Description
BACKGROUND OF THE INVENTION
This invention relates to absorbable and nonabsorbable sutures for
closing wounds. In order for a material to be satisfactory as a
suture, it must be nontoxic and noncarcinogenic, have tissue
acceptance and be flexible yet strong enough to meet United States
Pharmacopeia (USP) standards even when tied in a surgical knot.
Naturally, it must also be sterilizable, be able to hold surgical
knots without slipping and have only a limited stretchability so
that under tension it does not exceed the stretch prescribed by USP
standards. In addition, it is desirable to have the suture add
something to the compendium of surgical materials already available
for use as sutures. Finally, it is desirable to have the suture
somehow contribute to the healing of the wound in which it is
used.
These last characteristics are the ones to which this invention
pertains. It has recently been discovered that pure aluminum (i.e.,
aluminum that is 99.9999 percent pure) accelerates wound healing by
an electrochemical reaction between the metal and the surrounding
tissues. The same effect is also achieved with pure magnesium,
although magnesium's wound-healing ability is not as great.
Monofilament sutures of either of these materials are not
practical, however, because they are too brittle and cannot meet
the knot-pull tensile strength requirements of the USP
specifications for monofilament sutures. In the second place, since
both aluminum and magnesium react with the surrounding tissues,
they undergo a chemical transformation and dissipate during the
wound-healing process and thus weaken the suture and lessen its
ability to keep the wound closed.
SUMMARY OF THE INVENTION
I have discovered that both these undesirable characteristics can
be overcome by providing a suture which is coated with a
wound-healing metal such as aluminum or magnesium. The core os such
a suture is preferably Dacron, nylon, polyester fiber or stainless
steel, though any other suitable suture material such as cotton,
silk, catgut (plain or chromicized), collagen (plain or
chromicized) or any other organic, inorganic, metallic or synthetic
material which lends itself to usage as a suture can also be used.
The core can be a standard monofilament suture or it can be a
twisted or braided suture made of any of these materials. Using
aluminum as a coating not only helps heal the wound faster, it
gives the advantage that the strength of the suture is not lessened
as the aluminum dissipates in the wound. On an absorbable suture
the aluminum or magnesium coating also acts as a temporary barrier
between the tissue cells and the absorbable material, thus
increasing the suture's useful life in the wound. The coating
should be as pure as possible because its wound-healing ability
diminishes with the number and amount of alloying materials in the
metal as well as with the number and amount of contaminants it
contains. Neither of these materials should comprise over 5 percent
impurities. Aluminum that is 99.9999 percent pure is preferred,
though if it contains 0.76 percent magnesium and less than 0.0009
percent of any other component, the coating is quite satisfactory.
Oxidation of the coating also reduces its activity and its
wound-healing ability. To give a suture the desired wound-healing
characteristic, the coating should be of the appropriate thickness.
A principal advantage of using either of these materials, and this
is particularly true of aluminum, is that it enables the fibrotic
reaction in wound healing to proceed at a controlled,
faster-than-ordinary rate. Thus, by controlling the thickness of
the coating, it is possible to insure that when it is healed there
will be no residual fibrotic reaction in the wound due to the
presence of the coating material. I have found that a thickness
from between about 6 to 40 microns is useful in achieving this
result with the range of about 10 to 20 microns being preferred in
order that the reactive coating material be substantially
completely dissipated from the suture core by the time the wound is
healed.
The coating process includes cleaning the suture core by any known
chemical or other process. When Dacron, nylon, silk or certain
other suture materials are used, it is also necessary to render
them dimensionally stable by thermosetting them in a known manner
at a temperature which is at least 10.degree. F. higher than any
temperature at which they are likely to be subjected later. Then
all suture materials are bombarded over their entire surface with
negatively charged particles under high vacuum with the result that
they become negatively charged. This should be done in a thin
atmosphere of pure nitrogen or one of the inert gases to prevent
oxidation. By then vaporizing the aluminum, the vapor is attracted
to and condensed on the suture material with a strong bond.
Vaporization of the aluminum can be accomplished by any convenient
known technique, such as by heating tungsten filaments over which
strips of aluminum are twisted or hung, or by using a laser beam or
by induction heating. If the filament method is used, the
vaporization should take place at as low a temperature as possible
to avoid vaporizing tungsten particles which would also be
deposited on the suture material and which are toxic to the
tissues. When sufficient aluminum has been vaporized and deposited
on the core material, the vacuum is broken and the coating process
is over. I have also discovered that (whether the core material is
bombarded before deposition or not) all the aluminum or magnesium
must be deposited on the core in a single session without breaking
the vacuum. Once the vacuum is broken, even if more wound-healing
metal is later deposited on the suture using a second vacuum, for
some reason the first or undercoating material appears to have lost
most of its wound-healing or reactive ability. Thus, the suture's
wound-healing ability will depend almost entirely on the thickness
of its second or last coating. To improve the adherence of the
wound-healing coating on metallic sutures, it is useful to minutely
etch the surface of the suture before subjecting it to the
bombardment treatment.
Further, other and additional aspects of the invention will appear
from the following description, the novel features of which will be
particularly pointed out in the appended claims.
BRIEF DESCRIPTION OF THE DRAWING VIEWS
FIG. 1 is a schematic perspective view of a vacuum chamber which
can be used to coat a suture in accordance with the invention.
FIG. 2 is a vertical elevation in cross section of the chamber of
FIG. 1.
FIG. 3 is a perspective view of a portion of the tungsten heating
element frame shown in FIG. 2.
FIG. 4 is a perspective view of a portion of the rotatable suture
rack frame shown in FIG. 2.
FIG. 5 is a vertical elevation view in cross section of another
kind of vacuum chamber usable in coating the suture core.
FIG. 6 is a plan view of the vacuum chamber of FIG. 5.
FIG. 7 is a cross section view of a coated Dacron suture according
to the invention.
DETAILED DESCRIPTION
Referring now more particularly to the drawings, the process of
coating Dacron core material with aluminum is begun by
thermosetting or dimensionally stabilizing the material in a known
manner by bringing it up to a temperature of between
300.degree.--360.degree. F. under a tension which can vary from
5--25 percent of its breaking tension depending on the residual
stretch to be left in the material. Certain other materials, such
as nylon or silk, must also be thermally set in this manner using
other known temperatures and tensions.
Then the suture must be cleaned to remove all reactive constituents
or substances from its surface. This can be done using standard
ultrasonic cleaning techniques for sutures or by subjecting it to
multiple washings in neutral nonreactive clean (USP) water.
Stainless steel sutures are usually cleaned in toluene. When the
material is clean, it is placed in a vacuum chamber 10 having one
open line 12 connected to a source of vacuum (not shown) and
another open line 14 connected to a source of nitrogen (not shown).
In operation the chamber is preferably drawn down to a high vacuum
of about 4 .times. 10.sup.-8 microns and is then filled with
nitrogen after which the vacuum is again drawn down to about 4
.times. 10.sup.-8 microns. Lower vacuums down to 3 .times.
10.sup.-4 microns can also be used, but the higher the vacuum the
better the deposition and the lower the vaporizing temperature will
be. By refilling the chamber this way, it is purged of air and all
its contaminants and contaminating influences and is filled with a
thin atmosphere which inhibits oxidation so the deposition process
can be carried out effectively and easily. When a stainless steel
suture is being coated, it is helpful if it can be heated while the
deposition is taking place because I have found that such heating
improves the bond between the coating and the suture.
In carrying out the process, with all suture materials it is
important that to the extent possible the entire surface of the
material be exposed not only to the conditioning step in which the
surface is treated to insure adequate bonding of the coating but
also that it face directly and be exposed on all sides to the
source of the metal being deposited on it. This can be accomplished
by rotating the material in the chamber 10. As seen in FIGS. 1--4,
chamber 10 includes a fixed cylinder 16 separated from the
cylindrical wall 18 of the chamber by a plurality of mounts 20.
Inside cylinder 16 is a cage 17 which can be rotated by a gear 22
rigidly connected to it about its central axis by means of a collar
24. A spider bearing 26 rotatably supports the collar along the
axis of the cylinder. Cage 17 includes an idler gear 19 at one end
and a driven gear 21 at its opposite end and the two gears are
connected to each other by a plurality of rods 23. Gear 21 is
releasably fixed to collar 24. A pinion gear 28 powered by shaft 30
driven by a motor 32 drives gear 22 to rotate collar 24 and thus
gear 21. Motor 32 is shown schematically outside the chamber in
FIG. 1.
Surrounding cage 17 there is a frame assembly 34 for carrying and
rotating the Dacron or other material to be coated. Inside the cage
is a nonrotating framework 36 for carrying and vaporizing the
aluminum to be deposited on the material.
Assembly 34 preferably includes four rack units 35 each of which
includes two frames 38 separated from each other but rigidly
mounted coaxially on a rotatable shaft 40. Each frame has a
plurality of fingers 41 protruding from its edges to enable the
Dacron 42 to be strung back and forth between opposing fingers on
the other frame on the shaft. The racks are independent but lie
parallel and 90.degree. apart from each other in a pair of rims 44
in which each shaft 40 is rotatably mounted (see FIG. 2). Mounted
on opposite ends of each shaft 40 beyond rims 44 is a gear 46 which
meshes either with idler gear 19 or driven gear 21 so that when the
cage rotates each rack unit 35 rotates about its shaft 40 in the
same direction. At the same time the whole assembly 34 rotates
about the central axis of the cylinder. Thus, when the cage
rotates, each of the racks 35 moves around the cylinder in addition
to rotating about the axis of its shaft 40.
The aluminum is supplied to the Dacron or other material on these
racks by a heater framework 36 mounted inside cage 17 between a cup
48 at one end and a mounting block 50 at the other. Framework 36
includes four heater racks 52 each of which includes four or more
tungsten filaments 60 on which are placed or twisted the strips of
aluminum 62 which are to be vaporized. These racks are mounted
parallel each other and 90.degree. apart on a pair of frames 54 at
opposite ends of each rack and frames 54 are rigidly mounted
coaxially on a shaft 56. One end of the shaft is mounted in cup 48
and the other end extends through gears 21 and 22 and collar 24 to
mounting block 50 in the rear of the chamber. The end of the shaft
in the mounting block has a rectangular cross section 58 to prevent
the shaft and the framework from rotating. Cup 48 is mounted
coaxial with assembly 34 on one side of gear 19 which has one end
of a stub shaft 64 fixedly mounted on its opposite side. The other
end of stub shaft 64 is journaled in a spider 68, the radial tips
of which are releasably attached to the forward end of cylinder 16.
In operation, cage 17 rotates at one speed, suture racks 35 rotate
around their shafts 40 driving assembly 34 around the cylinder in
the same direction but at a slower speed than the cage. Heater
racks 52, framework 36 and spider 68 remain stationary. In this way
all the surfaces of the Dacron or other material are brought close
to the source of the aluminum vapor.
A door 72 is provided to close the open front end of the chamber
and is equipped with conventional means for sealing the chamber
against air leaks when a vacuum is drawn. A conventional spark gap
unit 74 is also provided in the chamber to detect the presence of
substantial amounts of free metal in the chamber during deposition
of the metal. The chamber also includes a known device 76 for
bombarding the material mounted on racks 35 with negatively charged
particles such as electrons. The device is shown schematically in
FIG. 2 and is connected to a control (not shown) outside the
chamber by wires 70. Preferably the device produces a stream of
electrons accelerated through a potential of 25,000--30,000 volts
for at least 5 minutes, while the racks 35 are rotating to insure
that all the surfaces of the Dacron have been bombarded and become
negatively charged.
After the Dacron has undergone this conditioning treatment, the
aluminum deposition begins. In the device shown in FIGS. 1--4 in
the drawings, this is accomplished by energizing one of the
tungsten filaments on each rack 52 at a time. Under a vacuum,
aluminum vaporizes into positively charged particles at
temperatures ranging from 800.degree. to 1500.degree. F. The
precise temperature depends on the purity of the aluminum and the
extent of the vacuum. Electrical controls (not shown) are provided
outside the chamber to insure that the temperature of the filaments
doesn't get too hot. As soon as all the aluminum that will vaporize
from these filaments at the desired temperature has been given off,
the filaments are turned off. The existence of this condition is
detected by observing the spark gap unit to see when the residual
amount of free aluminum in the atmosphere within the chamber is not
sufficiently concentrated to conduct electricity across the gap of
the unit. When this occurs, the condition has been reached, and
after the first set has been turned off, another set of filaments
is energized to vaporize additional aluminum. This sequence is
followed again and again until all the filaments in the chamber
have been energized and no more aluminum can be vaporized at the
desired temperature. The aluminum particles are initially attracted
to the suture because of the potential difference between them; and
while the deposition process is going on, the cage, racks, gears,
frames and assemblies are rotating to expose as much of the surface
of the suture material as possible and to get it as close as
possible to the vaporized aluminum source. Wiring 78, shown
schematically in FIGS. 1 and 2, connects the filaments with the
controls (not shown) and permits them to be selectively
energized.
When the deposition is finished, the vacuum is released and the
coated suture is removed from the chamber by removing cylinder 16
along guide tracks 80 (see FIG. 1).
As seen in FIGS. 5 and 6, the Dacron or other suitable suture core
material need not be wound between fingers on spaced apart frames,
as in FIGS. 2 and 4, but can be stored on spools 110 which can be
stacked one on top of the other and fixed to a rotating shaft 112
driven by a motor 114 in the base 102 of a different kind of vacuum
chamber. This type of chamber comprises a metal bell jar 100 which
is releasably sealable to the base which has a vacuum line 104 and
a nitrogen-purging line 106 opening within the jar. The chamber
also includes a known electron bombardment device 108 shown
schematically, a known spark gap unit 120 and a supply of aluminum
for vaporization as in the first type chamber. Though the aluminum
supply shown in FIGS. 5 and 6 comprises strips 122 of aluminum
placed or twisted on tungsten filaments 124, it should be realized
that the supply could comprise an aluminum bar which is vaporizable
by a laser beam or by induction heating. The essential difference
between this type chamber and that shown in FIGS. 1--4 is that here
there has to be at least one takeup spool and one feed spool in the
chamber. As shown in FIG. 6, there are two stacks of each type,
reference character 110a referring to the feed spools and 110b to
the takeup spools. The suture material 116 is threaded from spools
110a over and through a set of three idler rollers 118 to spools
110b in such a way that all surfaces of the material can be
directly exposed to the source of vaporized aluminum by rotating
the spools so as to transfer the material from one spool to
another. Then, by rotating the spools, all the suture material may
be bombarded and coated with aluminum. The finished product has a
cross section like that shown in FIG. 7 in which 126 is the suture
core and 128 the coating.
If desired, a nonabsorbable coated suture according to this
invention can be left in the body as a supporting element even
after the coating has been dissipated. It is still useful in
strengthening the tissues around the location of the healed wound
even after the coating is gone.
It will be understood that various changes in the details,
materials, steps and arrangements of parts, which have been herein
described and illustrated in order to explain the nature of the
invention, may be made by those skilled in the art within the
principle and scope of the invention as expressed in the
claims.
* * * * *