U.S. patent number 3,760,969 [Application Number 05/179,413] was granted by the patent office on 1973-09-25 for container closure.
This patent grant is currently assigned to Takeda Chemical Industries, Ltd.. Invention is credited to Masahiko Fujita, Osamu Kawahara, Yoshiharu Matsukura, Mamoru Sakagami, Tsugio Shimamoto.
United States Patent |
3,760,969 |
Shimamoto , et al. |
September 25, 1973 |
CONTAINER CLOSURE
Abstract
A container closure member adapted to sealably close an access
opening of a glass bottle for solutions, which has a leg-like
portion sealingly situated in the access opening. This closure
member comprises a rubber covering plug formed with an annular
protrusion and a shaped form of synthetic resin formed with an
annular groove and firmly contacted with the covering plug with its
annular groove receiving therein the annular protrusion of the
covering plug. The diameter of the shaped form is smaller than that
of a flange of the storage vessel, but larger than that of the
access opening so that a tight contact between the closure member
and the storage vessel can be advantageously ensured.
Inventors: |
Shimamoto; Tsugio (Takarazuka,
JA), Fujita; Masahiko (Suita, JA),
Matsukura; Yoshiharu (Higashiosaka, JA), Kawahara;
Osamu (Nara, JA), Sakagami; Mamoru (Gojo,
JA) |
Assignee: |
Takeda Chemical Industries,
Ltd. (Higashi-ku, Osaka, JA)
|
Family
ID: |
13735394 |
Appl.
No.: |
05/179,413 |
Filed: |
September 10, 1971 |
Foreign Application Priority Data
|
|
|
|
|
Sep 16, 1970 [JA] |
|
|
45/81043 |
|
Current U.S.
Class: |
215/247;
215/DIG.3; 215/274; 215/364 |
Current CPC
Class: |
B29C
45/14 (20130101); A61J 1/1406 (20130101); B65D
51/002 (20130101); A61J 1/1468 (20150501); B29L
2031/565 (20130101); B29C 43/18 (20130101); A61M
2207/00 (20130101); B29C 2043/3444 (20130101); Y10S
215/03 (20130101); B29L 2031/7544 (20130101) |
Current International
Class: |
B29C
45/14 (20060101); A61J 1/00 (20060101); B65D
51/00 (20060101); B29C 43/18 (20060101); B65d
039/00 () |
Field of
Search: |
;215/37R,38R,40,48,DIG.3 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
Primary Examiner: Norton; Donald F.
Claims
What is claimed is:
1. A container for medical injection solutions comprising a storage
vessel with a defined access opening and a closure member, said
closure member comprising a form composed of a thin film of a
fluorocarbon resin and capable of sealably closing said opening and
formed with an annular recessed portion adapted to be situated in
said opening when said form is sealably covering said opening, a
rubber covering plug pierceable by a hypodermic needle and formed
with an annular protrusion adapted to be received in said annular
recessed portion of said form, said annular protrusion being
inwardly recessed at a position adjacent to the point at which said
protrusion is integrally connected with the remainder of said
covering plug, whereby a recessed annular gap can be obtained
between the outer peripheral surface of said annular recessed
portion and the inner surface of said vessel defining said access
opening when said closure member sealably closes said opening, the
maximum outside diameter of said form being smaller than that of
said covering plug, but larger than the diameter of said opening,
whereby the remaining annular surface of said covering plug which
is defined by the difference between the diameters of said covering
plug and said form directly contacts a flange of said storage
vessel positioned adjacent to said opening in a tight manner, and
sealing means for sealingly securing said closure member to said
storage vessel and overlying the periphery of said covering
plug.
2. A container as claimed in claim 1 wherein the surface of said
form which contacts said covering plug and the surface of said plug
which contacts said form are rough so that a relatively firm
contact therebetween can be obtained without necessitating the use
of any adhesive agent.
3. A container as claimed in claim 1 wherein said annular
protrusion of said covering plug has its inside peripheral surface
flared in the direction away from the access opening of the storage
vessel.
4. A container as claimed in claim 7 wherein said fluorocarbon
resin is selected from the group consisting of a
trifluorochloroethylene polymer, a tetrafluoroethylene polymer and
a tetrafluoroethylene-hexafluoropropylene copolymer.
Description
The present invention relates to an improved closure member for
solution containers and, more particularly, to a pierceable closure
member for medicine bottles and a method of forming the same.
In any country where the medical administration is more or less
advanced, standards for medical supplies are naturally strict with
few exceptions to the quality of a closure member for containers
containing therein medical injection solutions or other valuable
medical solutions. In other words, the closure member of the type
above referred to should have a relatively higher quality so that
the valuable solution contained therein cannot be contaminated by
material and/or additives employed to manufacture such closure
member. Once the closure member closing a medical container such as
vial or the like contaminates the solution contained therein in
such a way that material and/or additives employed to manufacture
such closure member has been desolved into the solution and/or that
some of the additives have been adsorb to a surface portion of the
closure member accessible to the solution, some or all of the
characteristics, for example, the potency, the colour and the pH,
of the solution will be degraded.
To avoid the above mentioned disadvantages, various proposals have
heretofore been made to improve the closure member of the type
above referred to. Of which, a closure member coated in part or in
whole with a film of chemically stable material, for example,
tetrafluoroethylene polymer or Teflon [Du Pont's Reg. trademark]
has largely been accepted because of its chemical performance
superior to that afforded by any other coating materials.
However, the famous saying, "So many men, so many minds," may apply
even among the closure members of different structures heretofore
proposed which are coated in part or in whole with a film of the
chemically stable material.
Of them, exemplary types of the closure member are such as
disclosed in the U.S. Pat. Nos. 3,198,368 and 3,552,591, of which a
common feature resides in the employment of a disc-like film of
Teflon that is contacted with the relevant surface of a rubber
covering or backing member during the process of vulcanization of
the latter. More specifically, the first numbered U.S. patent is
directed to a closure member apparently designed such that the
Teflon disc of a diameter substantially equal to that of the rubber
backing is contacted with one whole surface of the rubber backing
which is adapted to cover the opening of a solution container,
whereas the second numbered U.S. patent is such that, although the
Teflon disc has a diameter smaller than that of the rubber covering
member, but larger than that of the opening of a solution container
to be closed thereby, so as to contact a substantially central
portion of the relevant surface of the rubber covering member, the
rubber covering member is provided at its outer periphery or rim
with a downwardly extending annular ridge engageable with the
bevel-shaped upper peripheral edge of the flange formed around a
neck portion of the solution container.
So long as the closure member is in the form of flat structure such
as disclosed in the first numbered U.S. patent, it has been found
that a substantially central portion of the closure member has a
tendency to be depressed inwardly or outwardly of the solution
container during the metal ring sealing operation in which a metal
ring is sealed over the periphery of the closure member under
relatively higher pressure to insure tight contact between said
closure member and the container opening. Once the central portion
of the closure member is depressed inwardly or outwardly as
hereinbefore described, airtightness at the contact area between
the closure member and the container opening will be lost to an
extent that air or the valuable solution in the container is
permitted to penetrate into or leak out of the container,
respectively. This is true in the case where the rubber backing
member is lined with the Teflon disc covering the whole surface
thereof, in view of the fact that Teflon or a similar hard material
has been well recognized as unable to adapt itself sufficiently to
unevennesses of such a solution container made of glass, metal or
other hard material unless otherwise at least a portion of the
container accessible with the closure member is precisely
polished.
In this respect, the closure member as disclosed in the second
numbered U.S. patent has many advantages over that disclosed in the
first numbered U.S. patent. However, this closure member of the
second numbered U.S. patent is very complicated so that the
container of special construction nust be provided to enable the
closure member to exhibit its excellent performance. In other
words, for this closure member, the existing container forming
equipment must be remodeled, or otherwise new container forming
equipment must be provided for manufacturing the container of which
the flange at the neck portion can accommodate the closure member
such as disclosed in the second numbered U.S. patent. This closure
member is similarly in the form of substantially flat structure
and, to avoid the depression at the central portion thereof, an
annular groove is also formed on the relevant surface of the
closure member at a position slightly spaced from the outermost rim
or periphery of said closure member. In this arrangement, while the
Teflon disc of a diameter larger than that of the container opening
is covered over the central portion of the closure member with its
peripheral edge slightly bent inwardly of the annular groove, the
remaining portion of the closure member positioned between the
annular groove to the outermost rim is adapted to insure tight
contact between said closure member and the flange of the
container.
Although the labyrinth-like annular groove formed on the relevant
surface of the closure member is effective to prevent the central
portion thereof from being inwardly or outwardly depressed under
the influence of a relatively higher pressure usually applied
during the metal ring sealing operation, it is apparent that a
method of manufacturing the closure member of the above complicated
construction is complicated as well. Despite the fact that the
second numbered U.S. patent has also disclosed the method thereof
wherein a substantially circular rubber block having one surface
contacted with the Teflon disc of the diameter slightly larger than
that of the rubber block is vulcanized and compression-molded into
the resultant closure member in a molding machine, centering of the
rubber block with respect to a stationary die of the molding
machine is too difficult. For example, the die is provided with an
annular projection which complies with the annular groove of the
resultant closure member, the inside diameter of the annular
projection being smaller than the diameter of the Teflon disc.
Accordingly, prior to the compression force to be applied to the
rubber block by means of a movalve die of the molding machine, the
rubber block must be mounted on the stationary die in such a way
that the outermost peripheral edge of the Teflon disc contacted to
the rubber block should be psoitioned atop the annular projection.
This procedure is too difficult, or otherwise time-consuming, so
that mass production of the closure member will be hampered. The
reason for the diameter of the Teflon disc being larger than the
inside diameter of the annular projection of the stationary die is
because the peripheral edge of the Teflon disc should, when the
resultant closure member is completely formed, be slightly bent
inwardly of the annular groove of the closure member to ensure that
the Teflon disc is tightly engaged with the rubber covering member.
However, this is apparently of no significant assistance unless the
solution container, and hence the closure member, is of a
relatively larger size.
Accordingly, an essential object of the present invention is to
provide an improved pierceable closure member for solution
containers wherein the above mentioned disadvantages inherent in
the conventional closure member of this kind have substantially
been eliminated.
Another object of the present invention is to provide an improved
pierceable closure member for solution containers which prevents
the contamination of a valuable medical or other solution contained
in the container nor the loss of chemicals stored in said
container.
A further object of the present invention is to provide an improved
pierceable closure member for solution containers which prevents
the leakage of a valuable medical or other solution stored in the
container.
It is a related object of the present invention to provide a method
of manufacturing the improved closure member which satisfies the
above mentioned objects without any formation of pinholes in a
shaped form of synthetic resin used to contact the covering
plug.
According to the present invention, there is provided a container
for medical injection solutions comprising a storage vessel with a
defined access opening and a closure member adapted to tightly
close said access opening. The closure member is formed on one
surface adjacent to the access opening of the storage vessel
integrally with a leg-like structure adapted to sealably inserted
in the access opening, and includes a rubber covering plug formed
with an annular protrusion and a shaped form made from a film of
synthetic material and formed with an annular groove or recess in
which said annular protrusion is tightly situated, said annular
protrusion and said annular groove constituting the leg-like
portion of the closure member. The diameter of the shaped form is
smaller than that of the covering plug, but larger than the
diameter of the access opening so that a tight contact between the
closure member to the storage vessel can be ensured without any
possible occurrence of leakage of a solution contained in the
container.
Furthermore, in view of the provision of the leg-like portion in
the closure member according to the present invention, it can be
advantageously appreciated that the centering of the closure member
to the access opening of the storage vessel can be facilitated
without forcing one who handles the storage vessel to watch the
course of procesure.
In addition, according to the present invention, the shaped form is
firmly contacted with the covering plug to an extent that, even if
a needle is pierced through the closure member very often in a
violent manner, no detachment of the shaped form from the covering
plug takes place. To this end, one surface of the shaped form to be
contacted with the covering plug is roughened by the treatment with
a natrium containing solution to permit the raw rubber material for
the covering plug to compensate the roughness on the surface of the
shaped form during the molding operation.
According to another preferred embodiment of the present invention,
the leg-like portion of the closure member is inwardly ressed on
the outside periphery thereof at a position adjacent to the root
with the inside periphery being tapered in the direction opposite
to the access opening so that, in addition to the tight contact
between the covering plug and the storage vessel, another tight
contact can be obtained between a portion adjacent to the free end
of said leg-like portion of the closure member and the storage
vessel. Since the double contacts can be available, the tightness
of the container can be substantially improved.
The present invention also pertains to a method of manufacturing
the closure member wherein each closure member can be obtained by
molding and vulcanizing a raw rubber material in a cavity of a
molding machine which defines the shape of the resultant closure
member. In this method of the present invention, streams of raw
rubber material are directed to the outer peripheral edge of each
of the forms lying in the mold so that no warping of the peripheral
edge of the form will occur during the molding operation. Of
course, in view of the provision of the annular groove in the
shaped form, centering of the form with respect to the mold can be
easily performed without difficulty.
These and other objects and features of the present invention will
become apparent from the following description taken in connection
with preferred embodiments thereof with reference to the attached
drawings, in which;
FIG. 1 is a schematic longitudinal section of an upper portion of a
medicine bottle of which the opening is closed by a closure member
constructed in accordance with the present invention,
FIG. 2 is a similar view to FIG. 1, showing another preferred
embodiment of the present invention,
FIG. 3 is a schematic diagram showing a molding machine for
manufacturing the closure member shown in FIG. 1 and,
FIG. 4 is a schematic diagram showing a molding machine for
manufacturing the closure member shown in FIG. 2.
Referring now to FIG. 1, a solution container, for example, a
medicine bottle 1 made of glass or other rigid materials as have
been conventionally accepted and in cooperation with which the
present invention can be practically utilized has an opening or
mouth 2 defined by a neck portion 3, an uppermost portion of said
neck portion 3 being integrally formed with a flange 4 of suitable
thickness. In the condition shown in FIG. 1, the medicine bottle 1
is shown as having a closure member, generally indicated by 5 and
constructed in accordance with the teachings of the present
invention as will be mentioned later, fastened thereto so as to
tightly close the bottle opening 2 by means of a metal sealing ring
6 which is fitted over the periphery of the closure member 5 by the
customarily practiced metal ring sealing process.
The medicine bottle 1 having such closure member 5 may be of any
type, for example, a container for a medical injection solution, a
corrosive solution or other valuable solution which is to be used
in installments by repeatedly sticking the needle of a syringe
through the closure member 5 or to be stored for a fairly long
period of time.
The closure member 5 generally comprises a covering plug 7 made of
natural rubber or a synthetic rubber such as polyisoprene or
chloroprene and imparted with relatively higher elasticity,
strength and softness, and a form 8 made of a fluorocarbon resin
such as trifluorochloroethylene polymer, tetrafluoroethylene
polymer or tetrafluoroethylene hexafluoropropylene copolymer.
The covering plug 7 is integrally formed with an annular protrusion
7a of a height within the range of from 0.5 to 5 mm. which is
sealably engageable in the bottle opening 2 and with a shallow
recess 7b at a substantially central portion of the upper surface
of said covering plug 7, said shallow recess 7b being adapted to
define an area through which the needle or the like can be pierced.
This covering plug 7 of the above construction has the shape
substantially as shown, which can be obtained by an extrusion
molding process as will be mentioned later.
The form 8 of a thickness within the range of from 0.01 to 0.3 mm.,
preferably, 0.07 to 0.15 mm., is integrally formed with an annular
groove or recess 8a which coincides with the contour of the annular
protrusion 7a of the covering plug 7 for receiving therein said
protrusion 7a. This form can be obtained by heat-pressing a thin
film of a fluoro-carbon resin for about one minute under a
temperature of approximately 250.degree. and, thereafter, by
perforating the thin film thus heat-pressed to give such form
8.
The covering plug 7 and the form 8 are tightly contacted to each
other in such a way that the annular protrusion 7a of the covering
plug 7 is situated within the annular groove 8a of the form 8. Of
course, to ensure the tight contact therebetween, no adhesive agent
is employed, but the whole surface of the form 8 in contact with
the adjacent surface of the covering plug 7 has been treated with a
natrium containing solution to impart roughness on said surface of
said form 8, so that, during the formation of the closure member in
accordance with the method of the present invention, the roughness
on said surface of said form 8 can be substantially completely
filled up with raw rubber material employed to form the covering
plug 7. Once the rough surface of said form 8 is filled up with the
raw rubber material as hereinabove mentioned, it may be possibly
said that the tight contact between the covering plug 7 and the
form 8 takes place in a substantially similar manner as observed in
the formation of a blanket of snow on a steep mountainside or on
rough ground. Accordingly, even without the use of any adhesive
agent, a sufficiently acceptable contact between the covering plug
7 and the form 8 can be obtained which is more firm than that
afforded where no surface of the form to be contacted with the
covering plug 7 is treated with the natrium containing
solution.
However, it is to be noted that, to demonstrate the optimum
performance of the closure member of the present invention, the
diameter D of the form 8 should be smaller than the diameter d of
the flange 4 which defines the bottle opening 2 of the diameter as
indicated by d.sub.1, but larger than the diameter d.sub.1 of said
opening 2, so that an annular uncovered area 7c is provided on the
surface of the covering plug 7 at a position between the outermost
peripheral edge of the form 8 and the outermost peripheral edge of
the covering plug 7. This uncovered area 7c of the covering member
7 is adapted, when the closure member 5 is in position as shown, to
directly contact the relevant portion of the flange 4. In this
connection, the difference between the diameter d of the flange 4
and the diameter D of the form 8, namely, the distance between the
outermost peripheral edges of the flange 4 and the covering plug 7
is preferably within the range of from one thirds to two third
(one-third to two-thirds) of the difference between the diameter d
of the flange 4 and the diameter d.sub.1 of the bottle opening 2.
If the direct contact area between the covering plug 7 and the
bottle 1 or the bottle flange 4 is reduced in such a way that the
difference between the diameter d and the diameter D becomes
smaller than that of one-third of the difference between the
diameter d and the diameter d.sub.1, a sufficient fluid-tightness
can no longer be imparted between the closure member 5 and the
bottle 1. On the other hand, if said direct contact area is
increased in such a way that the difference between the diameters d
and D becomes larger than that of two-thirds of the difference
between the diameters d and d.sub.1, this may result in the
reduction of the difference between the diameters d.sub.1 and D,
namely, the reduction of the size of the peripheral edge of the
form 8, so that, when the metal sealing ring 6 is formed over the
periphery of the closure member 5, the form 8 will be no longer
satisfactorily suspended in position with its peripheral edge being
tightly sandwiched between the covering plug 7 and the bottle
flange 4 under the influence of pressure exerted by the metal
sealing ring 6.
Although in the embodiment shown in FIG. 1 the outside diameter of
the annular protrusion 7a of the covering plug 7 is substantially
equal to the diameter d.sub.1 of the bottle opening 2 so that the
whole outside peripheral surface of the protrusion 7a may contact
the inner peripheral surface of the neck portion 3 of the bottle 1,
a similar annular protrusion of the outside diameter slightly
larger than the diameter of the bottle opening may be utilized.
Referring now to FIG. 2, the annular protrusion 7'a integral with
the covering plug 7 is inwardly recessed at a position
substantially adjacent to the outside annular root of said
protrusion to give a recessed gap 9 while the inside peripheral
surface 7d of the protrusion 7'a is preferably tapered toward the
opposite, inside annular root of said protrusion to represent a
skirt-like shape. In other words, the outside diameter of the
protrusion 7'a at a position substantially adjacent to the outside
root thereof is smaller than that at a position where the
protrusion 7'a is to be indirectly contacted with the inner
peripheral surface of the neck portion 3 of the bottle 1 through
the form 8.
While the covering plug 7 having the annular protrusion 7'a is
formed into the shape as shown and hereinbefore described, the form
8 is correspondingly shaped so as to meet the contour of the
covering plug 7 and contacted to the latter in the same manner as
described in connection with the first preferred embodiment with
reference to FIG. 1. However, the size of the peripheral edge of
the form 8 of FIG. 2 which is suspended over the bottle flange 4 is
substantially the same as hereinbefore described. In other words,
the size of the peripheral edge of the form 8 of FIG. 2 is defined
by the difference between the diameter D of the form 8 and the
diameter d.sub.1 of the bottle opening 2.
The minimum outside diameter, as indicated by D.sub.1, of the form
8, which is slightly larger than the outside diameter of the
protrusion 7'a at a position substantially adjacent to the outside
root thereof, is, in view of the provision of the recessed gap 9,
smaller than the outside diameter, as indicated by D.sub.2, located
adjacent to the annular free end of said protrusion 7'a. The
outside diameter D.sub.2 may be substantially equal to or slightly
larger than the diameter d.sub.1 of the bottle opening 2. If the
diameter D.sub.2 is slightly larger than the diameter d.sub.1,
insertion of the closure member 5 or, more specifically, the
annular protrusion 7'a, in the bottle opening 2 causes said
protrusion to be compressed in the peripheral direction so that, in
addition to the tight contact between the covering plug 7 and the
bottle flange 4 through the uncovered area 7c, another tight
contact between the closure member 5 and the bottle 1 can be
advantageously obtained. This is because, as can be understood by
those skilled in the art, upon compression of the annular
protrusion 7'a, stress can be exerted about the annular free end of
said protrusion in the radial direction to an extent that the tight
contact can be ensured.
In any event, the size of the recessed gap 9 is such that the ratio
of the difference between the diameters D.sub.2 and D.sub.1 to the
diameter D.sub.2 is within the range of from one one-hundreth to
ten one-hundreths and the radius of rounding is within the range of
from 0.1 to 2.0 mm., preferably, 0.3 to 1.0 mm. This recessed gap 9
may be present or not present when the closure member 5 is inserted
in the bottle opening 2.
Furthermore, the provision of the recessed gap 9 is effective to
ensure the tight contact between the covering plug 7 and the form 8
in view of the fact that the skirt-like annular protrusion 7'a
situated in the annular groove 8a of the form 8 which meets the
contour of the protrusion 7'a carries said form 8 from the inside
of the latter. Accordingly, it is apparent that, even if the
surface of the form 8 has been insufficiently treated with the
natrium containing solution, a possible detachment of the form 8
from the covering plug 7 can be substantially completely
eliminated. Without the provision of this recessed gap 9, the
performance of the closure member shown in FIG. 2 is substantially
the same as that of FIG. 1, since a difference merely exists in the
construction of the inside peripheral surface of the annular
protrusion.
To manufacture the closure member of the construction shown in
either FIG. 1 or FIG. 2, a method thereof will be hereinafter
described with reference to FIGS. 3 and 4 wherein a molding machine
is schematically shown as including a female mold A, a male mold B
and a hydraulically operated ram C, all being separable from each
other.
The female mold A is provided at its depth with a plurality of
equally spaced annular groove 10, each of which corresponds to the
annular protrusion of the closure member 5 and having the shape
which meets the contour of the form 8 and thus the annular
protrusion. The male mold B is formed with a plurality of cavities
11 for determining the shape of the covering plug during the
molding operation, the number of which corresponds to that of the
annular grooves 10. Each cavity 11 is communicated with a pot-like
portion 12 formed in said male mold B for receiving therein a
substantial amount of raw rubber material, through a plurality of
passages 13 each having a diameter of the value within the range of
from 0.5 to 1 mm. and equally spaced with each other such that the
opening of each of said passages 13 facing to the cavity 11 is
positioned above the peripheral edge of the form 8. Slidably
received in said pot-like portion 12 of the male mold B is the ram
C adapted to be driven by a suitable cylinder device (not shown) in
a manner known to those skilled in the art. It is to be noted that
the molding machine shown is of a design effective to vulcanize the
raw rubber material during the molding operation.
To manufacture the closure member 5 of the present invention, a
plurality of the forms 8 that have been prefabricated with its
relevant surface treated with the natrium containing solution as
hereinbefore described are first placed on the female mold A with
the annular groove 8a of each of the forms 8 being received in the
corresponding one of the annular groove 10 of said female mold A.
Thereafter, the male mold B is tightly sealed with the female mold
A and a substantial amount of raw rubber material for the covering
plug 7 is subsequently filled in the pot-like portion 12 of the
male mold B. This supply of the raw rubber material may be made
manually or by means of a pumping device (not shown). The ram C is
then moved toward the male mold B so that the raw rubber material
in the pot-like portion 12 can be poured under pressure into the
cavities 11 through the passages 13 and then the annular grooves 8a
of the forms 8 and, thereafter, the raw rubber material contained
in the cavities 11 is subjected to vulcanization.
Upon completion of the vulcanization, the units A, B and C are
separated from each other and a plurality of the closure members 5
can be obtained by removing them from the male mold B.
It is to be noted that, since the opening of each of the passages
13 facing to the cavity 11 is designed so as to position above the
peripheral edge of the form 8, streams of the raw rubber material
under pressure pouring from the pot-like portion 12 into the cavity
11 through the passage 13 act to restrict the peripheral edge of
the form 8 from being warped.
Of course, the depth of each of the annular grooves 10 of the
female mold A is substantially equal to the height of the annular
protrusion 7a or 7'a.
The only difference between the molding machines shown in FIG. 3
and FIG. 4 resides in the shape of the annular groove 10 formed in
the female mold A. In other words, the machine shown in FIG. 3 is
adapted to manufacture the closure member shown in FIG. 1 while
that shown in FIG. 4 is adapted to manufacture the closure member
shown in FIG. 2. In either case, the most important feature of the
present invention resides in the location of the opening of each
passage 13 facing to the cavity 11 substantially as hereinbefore
described.
Furthermore, because of the provision of the annular protrusion in
the closure member, centering of the form 8 with respect to the
female mold A can be facilitated without any difficulty and the
displacement of the form 8 with respect to the covering plug 7 or
7' will never occur even during the molding operation.
To show the performance of the closure member of the present
invention, reference will be made to the following example which is
not intended to limit the present invention in any respect.
EXAMPLE
A film of tetrafluoroethylene copolymer, 0.13 mm. in thickness was
treated on its one surface with a halogen-eliminator containing
solution which had been prepared by mixing a solution containing
tetrahydrofuran and naphthalin with a dispersion containing natrium
or metallic natrium of the same mole as that of the naphthalin for
approximately 5 minutes. After this film had been washed with
aceton and then water and dried, the film was molded by means of a
press, heated up to 250.degree. and, after one minute, cooled down
to 180.degree., to give the molded form 8 of the shape
substantially are shown in FIG. 2. The dimensions of this form 8
including the radius of rounding of the recessed gap 9 are:
Diameter D 16.0 mm. Diameter D.sub.1 12.2 mm. Diameter D.sub.2 13.3
mm. Radius of Rounding 0.4 mm.
The form 8 thus obtained was placed on the female mold A shown in
FIG. 4 and, in accordance with the procedure as hereinbefore
described, the closure member, 19.0 mm. in diameter and 3.0 mm. in
thickness, having an annular protrusion of 1.87 mm. in height was
obtained. During the molding operation, vulcanization was carried
out under pressure at 160.degree. for ten minutes.
The composition of raw rubber material for the closure member thus
obtained are as follows:
Composition A Polyisoprene part 100 parts Zinc flower 5 parts
Sulphur 1.5 parts Benzothiazolyl disulfide 1 part Stearic acid 1
part Silica 30 parts Composition B Chloroprene 100 parts Zinc
flower 5 parts Magnesia 4 parts Ethylenethiourea 0.5 part;8c
Stearic acid 1 part Silica 30 parts
A number of glass vials each having a flange 4 of 19.0 mm. in
diameter d and an opening 2 of 13.0 mm. in diameter d.sub.1, the
opening of each of which is tightly closed with the closure member
of the above construction by means of the metal sealing ring 6,
were subjected to the following various tests:
Types of Test and Results
Extract-permeability Test: This is a test to determine to what
extent distilled water, contained in each glass vial at the rate of
5 ml. and heated up to 100.degree. for one hour, was contaminated
by the composition of the closure member. The result of this test
is expressed in the Table I in terms of UV adsorbance relative to
the specific wavelength employed.
Adsorption Test: This is a test to determine to what extent the
closure member adsorbs a specified compound of a solution of 5 ml.
contained in each glass vial. For this compound, 0.01 percent of
propylparaben and 0.1 percent of methylparaben were respectively
employed. In this example, each glass vial containing the solution
was allowed to stand for 30 days under room temperature, and the
degree of adsorption is expressed in the Table I in terms of
percentage.
Note: For comparision, each glass vial having the closure member
without the form 8 contacted to the covering plug 7 was also
subjected to the same tests. In addition, all of the glass vials
were tested in the inverted condition. ##SPC1##
From the foregoing, it now becomes clear that the closure member
constructed in accordance with the present invention is effective
to maintain the fluid tightness of the container without any
substantial influence on the solution contained in the container.
This fact is also supported by the tightness test, the results and
conditions of which are tabulated in Table II. However, it is to be
noted that each glass vial under the heading, "Comparision," had
its opening closed with a flat closure member comprising a rubber
layer and a Teflon [Du Pont's Reg. Trademark] layer, both having
the same diameter as that of the vial opening.
Although the present invention has been fully described in
conjunction with the preferred embodiments thereof, it is to be
noted that various changes and modifications are apparent to those
skilled in the art and, therefore, the present invention is not to
be limited thereby. Such changes and modifications, if they fall
within the scope of the present invention, should be construed as
constituting part of the present invention.
* * * * *