U.S. patent application number 17/592432 was filed with the patent office on 2022-05-19 for devices, systems and methods for improving scalp health.
The applicant listed for this patent is EDGE SYSTEMS LLC. Invention is credited to William Cohen, Roger Ignon, Ed F. Nicolas.
Application Number | 20220151861 17/592432 |
Document ID | / |
Family ID | |
Filed Date | 2022-05-19 |
United States Patent
Application |
20220151861 |
Kind Code |
A1 |
Ignon; Roger ; et
al. |
May 19, 2022 |
DEVICES, SYSTEMS AND METHODS FOR IMPROVING SCALP HEALTH
Abstract
According to some embodiments, a method of promoting hair growth
or hair stimulation in a subject comprises applying vacuum or
suction using a handpiece assembly along a targeted portion of the
subject's skin surface where hair growth or hair stimulation is
desired and providing at least one treatment material to said
targeted portion of the subject's skin surface, wherein the
application of vacuum or suction helps promote hair growth or
stimulate hair.
Inventors: |
Ignon; Roger; (Redondo
Beach, CA) ; Nicolas; Ed F.; (Signal Hill, CA)
; Cohen; William; (Los Alamitos, CA) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
EDGE SYSTEMS LLC |
Long Beach |
CA |
US |
|
|
Appl. No.: |
17/592432 |
Filed: |
February 3, 2022 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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15204939 |
Jul 7, 2016 |
11241357 |
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17592432 |
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62190243 |
Jul 8, 2015 |
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62320476 |
Apr 9, 2016 |
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International
Class: |
A61H 9/00 20060101
A61H009/00; A61H 7/00 20060101 A61H007/00; A61H 15/00 20060101
A61H015/00; A61H 15/02 20060101 A61H015/02; A61N 5/06 20060101
A61N005/06 |
Claims
1. A method of promoting hair growth or hair stimulation in a
subject, the method comprising: applying vacuum or suction using a
handpiece assembly along a targeted portion of the subject's skin
surface where hair growth or hair stimulation is desired; and
providing at least one treatment material to said targeted portion
of the subject's skin surface; wherein the application of vacuum or
suction helps promote hair growth or stimulate hair.
2. A method of promoting hair growth or hair stimulation in a
subject, the method comprising: applying positive pressure using a
handpiece assembly along a targeted portion of the subject's skin
surface where hair growth or hair stimulation is desired; and
providing at least one treatment material to said targeted portion
of the subject's skin surface; wherein the application of positive
pressure helps promote hair growth or stimulate hair.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS & INCORPORATION BY
REFERENCE
[0001] This application is a continuation application of U.S.
patent application Ser. No. 15/204,939, filed Jul. 7, 2016, which
claims priority to U.S. Provisional Patent Application No.
62/190,243, filed Jul. 8, 2015, and U.S. Provisional Patent
Application No. 62/320,476, filed Apr. 9, 2016. The entire contents
of each of the applications listed above are incorporated herein by
reference in their entireties.
[0002] The entireties of U.S. patent application Ser. No.
12/346,582, filed Dec. 30, 2008 and issued on Jan. 1, 2013 as U.S.
Pat. No. 8,343,116, U.S. patent application Ser. No. 11/392,348,
filed Mar. 29, 2006 and issued on Nov. 1, 2011 as U.S. Pat. No.
8,048,089, U.S. patent application Ser. No. 12/832,663, filed Jul.
8, 2010 and issued on Aug. 26, 2014 as U.S. Pat. No. 8,814,836,
International Patent Application No. PCT/US2014/024992, filed Mar.
12, 2014 and published on Sep. 25, 2014 as PCT Publ. No. WO
2014/151104 and International Patent Application No.
PCT/US2015/067531, filed Dec. 22, 2015 and published on Jun. 30,
2106 as PCT Publ. No. WO 2016/106396 are hereby incorporated by
reference herein and made a part of the present specification.
BACKGROUND
Field
[0003] This application relates generally to the promotion of hair
growth, and more specifically, to apparatuses, systems and methods
for facilitating hair growth by treatment of a subject's adjacent
skin tissue. The application also has applicability to any other
type of skin treatment procedure and other skin treatment devices
and systems.
SUMMARY
[0004] According to some embodiments, embodiments of the devices,
systems and methods disclosed herein have specific relevance to
treatment devices, systems and methods for the promotion of hair
growth and the preparation/treatment of skin in connection with
such hair growth. However, the features, advantages and other
characteristics disclosed herein may have direct or indirect
applicability in other applications, such as, for example, medical
devices and procedure, mechanical devices and non-skin treatment
devices and methods and/or the like. For example, the various
devices, systems and related methods described herein can be used
in other types of skin treatment procedures and protocols (non-hair
growth procedures), such as, e.g., for microdermabrasion of skin,
for treatment of acne, oily skin and other skin ailments and
conditions, for the removal of blackheads, sebum and/or other
substances from skin, for skin tightening, skin lightening,
anti-aging, anti-oxidant treatment and/or for any other type of
skin or tissue treatment.
[0005] According to some embodiments, devices, systems and methods
can be used to promote the growth of hair. For instance, one or
more fluids and/or other substances can be selectively delivered to
and/or into the scalp (e.g., at least partially into a subject's
skin tissue) to help stimulate hair follicle growth and/or
otherwise promote hair growth. As discussed in greater detail
herein, the delivery of such materials on and/or into a subject's
skin surface (e.g., scalp) can be facilitated with the assistance
one or more infusion or penetration features and methods. For
example, the delivery of the desired or required treatment
materials (e.g., growth factors) can be facilitated by use of one
or more of the following: use of suction or vacuum (e.g., to
stimulate blood flow), use of force, pressure and/or mechanical
agitation (e.g., mechanical pulsing using air delivery to a
targeted skin surface), use of needles or other tissue penetration
devices or tools, use of exfoliation or massaging to targeted skin
tissue, use of thermal conditioning (e.g., heating or cooling) of
the targeted skin tissue, use of energy delivery simultaneously
with the delivery of treatment materials (e.g., ultrasound, laser,
radiofrequency energy, microwave energy, electric current or
stimulation, iontophoresis, etc.), use of light (e.g., red light,
ultraviolet light, etc.), use of hair implants or other hair growth
systems, methods and/or technologies) and/or the like.
[0006] According to some embodiments, an engagement member or
shroud configured to be positioned along a distal end of a
handpiece assembly, the engagement member comprising a proximal end
configured to attach to a proximal component of a handpiece
assembly, a distal end configured to contact and engage with a skin
surface being treated, a body extending between the proximal end
and the distal end that is configured to accommodate for
irregularities and other contours along the skin surface being
treated, wherein the engagement member is flexible, and wherein the
engagement member is configured to facilitate capture of liquids
present along the skin surface being treated during use.
[0007] According to some embodiments, the engagement member or
shroud comprises a rubber or other elastomeric material (e.g.,
silicone rubber). In some embodiments, the engagement member
comprises at least one bellow or other collapsible member to
facilitate the maneuverability of the engagement member relative to
the skin surface being treated.
[0008] In some embodiments, the engagement member or shroud is
configured to couple to a tip of the handpiece assembly, wherein
the proximal end of the engagement member is configured to fixedly
or removably coupled to the tip. In some embodiments, the
engagement member or shroud is configured to couple to a main body
portion of the handpiece assembly, wherein the proximal end of the
engagement member is configured to fixedly or removably coupled to
the main body portion of the handpiece assembly.
[0009] According to some embodiments, a method of promoting hair
growth or hair stimulation in a subject comprises applying vacuum
or suction using a handpiece assembly along a targeted portion of
the subject's skin surface where hair growth or hair stimulation is
desired and providing at least one treatment material to said
targeted portion of the subject's skin surface, wherein the
application of vacuum or suction helps promote hair growth or
stimulate hair.
[0010] According to some embodiments, a method of promoting hair
growth or hair stimulation in a subject comprises applying positive
pressure using a handpiece assembly along a targeted portion of the
subject's skin surface where hair growth or hair stimulation is
desired and providing at least one treatment material to said
targeted portion of the subject's skin surface, wherein the
application of positive pressure helps promote hair growth or
stimulate hair.
[0011] According to some embodiments, the vacuum or suction is
applied continuously or intermittently. In some embodiments, the
vacuum or suction is applied intermittently using a pulsing device.
In one embodiment, the pulsing device is configured to create
alternating first and second pressure s along the subject's skin
surface, wherein the first pressure is greater than the second
pressure, and wherein the second pressure is a vacuum or suction.
In some embodiments, the first pressure is a positive pressure. In
some embodiments, the first pressure is a vacuum or suction.
[0012] According to some embodiments, a distal end of the handpiece
assembly is configured to contact the subject's skin surface. In
some embodiments, the distal end of the handpiece assembly
comprises a tip. In some embodiments, the tip is removable from a
proximal portion of the handpiece assembly. In one embodiment, the
tip comprises at least one suction port or opening through which
vacuum or suction is selectively applied.
[0013] According to some embodiments, the at least one treatment
material comprises one or more of the following: growth factors
(e.g., human-derived, non-human derived, liposome (courier)
chemically altered growth factors, etc.), amino acids (e.g.,
leucine, isoleucine, valine, etc.), antioxidants, minoxidil, other
antihypertensive vasodilators, finasteride, dutasteride,
ketoconazole, spironolactone, flutamide, catechin, epicatechin,
other phytochemicals, carnitine, rejuvaplex, copper peptides, other
hair growth-stimulating agents, other pharmaceuticals and
non-pharmaceuticals, plant-derived products, cleansing or
pre-cleansing shampoos, other cleansing or pre-cleansing solutions
(e.g., salicylic acid, GlySal.TM. (glycolic acid and salicylic acid
mix), other acids, etc.), and other natural and synthetic
materials. In some embodiments, the at least one treatment material
is contained in a bottle, said bottle being in fluid communication
with the handpiece assembly. In one embodiment, the at least one
treatment material is contained in a cartridge, said cartridge
being configured to secure to the handpiece assembly. In some
embodiments, the at least one treatment material is positioned on a
tip of the handpiece assembly, wherein the at least one treatment
material is configured to at least partially dissolve or release in
the presence of a liquid.
[0014] According to some embodiments, the application of vacuum or
suction helps promote blood flow at or near the targeted portion of
the subject's skin surface. In some embodiments, the method further
comprises at least partially exfoliating the skin surface of the
subject. In some embodiments, at least partially exfoliating the
skin surface of the subject comprises exfoliating using an abrasive
surface or member. In one embodiment, at least partially
exfoliating the skin surface of the subject comprises exfoliating
using a chemical exfoliating agent. In some embodiments, at least
partially exfoliating the skin surface of the subject precedes
providing at least one treatment material to said targeted portion
of the subject's skin surface. In some embodiments, the at least
one treatment material comprises a growth factor.
[0015] According to some embodiments, the method further comprises
providing a light treatment to the skin tissue. In some
embodiments, the light treatment comprises providing red or blue
light to the skin tissue. In one embodiment, the light treatment is
used to activate the at least one treatment material to facilitate
hair growth or stimulate hair.
[0016] According to some embodiments, the method additionally
comprises at least partially penetrating the skin surface of the
subject. In some embodiments, penetrating the skin surface of the
subject comprises using at least one needle assembly configured to
selectively penetrate skin tissue. In some embodiments, the at
least one needle assembly is configured to open up passages within
the skin of the subject, said passages leading to or near a
subject's follicles. In some embodiments, the at least one needle
assembly is coated or otherwise provided with at least one
treatment material. In one embodiment, the at least one needle
assembly comprises a plurality of hollow needles, wherein at least
one treatment material is configured to be delivered through
passages of the hollow needles.
[0017] According to some embodiments, the method further comprises
massaging or otherwise agitating the targeted portion of the
subject's skin surface to facilitate the delivery of the at least
one treatment material deeper into said skin surface. In some
embodiments, the massaging or agitating results in at least
partially opening pores along the subject's skin surface to
facilitate the passage of the at least one treatment materials
therethrough. In one embodiment, the massaging or agitating
comprises moving a handpiece comprising a surface with at least one
non-linear feature relative to said skin surface. In some
embodiments, the at least one non-linear feature comprises an
undulating yet smooth surface or feature.
[0018] According to some embodiments, the method additionally
comprises performing the procedure at or near a portion of skin
tissue that has received hair implants. In some embodiments, the
method further comprises implanting at least a plurality of hair
follicles at or near the portion of the skin tissue being
treated.
[0019] According to some embodiments, the method additionally
comprises heating or cooling the targeted portion of the subject's
skin surface being treated. In some embodiments, heating or cooling
the skin surface comprises using a separate thermally-conditioned
device (e.g., a thermoelectric device, Peltier element, etc.).
[0020] According to some embodiments, further comprises providing
energy to the targeted portion of the subject's skin surface to
enhance hair growth or hair stimulation. In some embodiments,
wherein the energy provided to the skin tissue comprises one or
more of the following: radiofrequency (RF) energy, microwave
energy, ultrasound energy, iontophoresis and laser.
BRIEF DESCRIPTION OF THE DRAWINGS
[0021] These and other features, aspects and advantages of the
present application are described with reference to drawings of
certain embodiments, which are intended to illustrate, but not to
limit, the present application and the inventions disclosed
therein. It is to be understood that these drawings are for the
purpose of illustrating the various concepts disclosed herein and
may not be to scale.
[0022] FIG. 1 illustrates a perspective view of a handpiece
assembly configured for use with skin treatment systems, including
those adapted to promote hair growth, according to one
embodiment;
[0023] FIG. 2 schematically illustrates a handpiece assembly being
in fluid communication with a fluid delivery system or manifold
system according to one embodiment;
[0024] FIGS. 3A-3E illustrate various views of a system comprising
air pulsing, according to one embodiment;
[0025] FIGS. 4A-4E illustrate various views of a system comprising
air pulsing and needle penetration, according to one
embodiment;
[0026] FIG. 5 illustrates a side view of a handpiece assembly
having an engagement member or shroud along its distal end;
[0027] FIGS. 6 and 7 illustrate the embodiment of FIG. 5 in two
different orientations during a skin treatment procedure;
[0028] FIG. 8 illustrates a frontal perspective view of the
engagement member and tip;
[0029] FIG. 9 illustrates a frontal perspective view of another
embodiment of an engagement member or shroud positioned along the
distal end of a handpiece assembly;
[0030] FIGS. 10A and 10B illustrate different embodiments of a
light wand device configured for use with a hair growth and/or
other skin treatment system;
[0031] FIGS. 11A and 11B illustrate a station for a thermal
conditioning system according to one embodiment;
[0032] FIGS. 12A and 12B illustrate different views of an assembly
comprising a rollerball for use with a treatment system according
to one embodiment;
[0033] FIG. 13 illustrates a perspective view of an assembly
comprising a wicking member for use with a treatment system
according to one embodiment;
[0034] FIG. 14 schematically illustrates a side view of an assembly
comprising a wicking or porous member for use with a treatment
system according to one embodiment; and
[0035] FIG. 15 schematically illustrates a side view of an assembly
comprising a wicking or porous member and a rollerball for use with
a treatment system according to one embodiment.
DETAILED DESCRIPTION
[0036] Although the various embodiments of the devices, systems and
methods disclosed herein have specific relevance to treatment
devices, systems and methods for the promotion of hair growth and
the preparation/treatment of skin in connection with such hair
growth, the features, advantages and other characteristics
disclosed herein may have direct or indirect applicability in other
applications, such as, for example, medical devices and procedure,
mechanical devices and non-skin treatment devices and methods
and/or the like. For example, the various devices, systems and
related methods described herein can be used in other types of skin
treatment procedures and protocols (non-hair growth procedures),
such as, e.g., for microdermabrasion of skin, for treatment of
acne, oily skin and other skin ailments and conditions, for the
removal of blackheads, sebum and/or other substances from skin, for
skin tightening, skin lightening, anti-aging, anti-oxidant
treatment and/or for any other type of skin or tissue
treatment.
[0037] According to some embodiments, devices, systems and methods
can be used to promote the growth of hair. For instance, one or
more fluids and/or other substances can be selectively delivered to
and/or into the scalp (e.g., at least partially into a subject's
skin tissue) to help stimulate hair follicle growth and/or
otherwise promote hair growth. As discussed in greater detail
herein, the delivery of such materials on and/or into a subject's
skin surface (e.g., scalp) can be facilitated with the assistance
one or more infusion or penetration features and methods. For
example, the delivery of the desired or required treatment
materials (e.g., growth factors) can be facilitated by use of one
or more of the following: use of suction or vacuum (e.g., to
stimulate blood flow), use of force, pressure and/or mechanical
agitation (e.g., mechanical pulsing using air delivery to a
targeted skin surface), use of needles or other tissue penetration
devices or tools, use of exfoliation or massaging to targeted skin
tissue, use of thermal conditioning (e.g., heating or cooling) of
the targeted skin tissue, use of energy delivery simultaneously
with the delivery of treatment materials (e.g., ultrasound, laser,
radiofrequency energy, microwave energy, electric current or
stimulation, iontophoresis, etc.), use of light (e.g., red light,
ultraviolet light, etc.), use of hair implants or other hair growth
systems, methods and/or technologies) and/or the like.
[0038] The various steps, technologies and/or other features
described herein can be used alone or in conjunction with one
another to effect a particular result, e.g., the promotion of hair
growth in a subject, the strengthening of existing or new hair in a
subject and/or the like. As noted above, the various devices,
systems and related methods described herein can be used in other
types of skin treatment procedures and protocols (non-hair growth
procedures), such as, e.g., for microdermabrasion of skin, for
treatment of acne, oily skin and other skin ailments and
conditions, for the removal of blackheads, sebum and/or other
substances from skin, for skin tightening, skin lightening,
anti-aging, anti-oxidant treatment and/or for any other type of
treatment.
Delivery of Treatment Fluids and/or Other Materials
[0039] In some embodiments, in order to promote hair growth in a
targeted portion of a subject skin (e.g., the subject's scalp), one
or more treatment fluids and/or other materials can be delivered
to, and preferably into (at least partially), a subject's skin
tissue. For example, in some arrangements, growth factors can be
delivered to the subject's skin surface. Growth factors can
include, among other things, human-derived growth factors (e.g.,
FGF9 and other fibroblast growth factors (FGF), human fibroblast
conditioned media and other fibroblast growth factors, epidermal
growth factor (EGF)-related ligands, transforming growth
factor-beta (TGF-beta), insulin-like growth factor (IGF),
hepatocyte growth factor/scatter factor (HGF/SF), platelet-derived
growth factor (PDGF), etc.), synthetic growth factors, liposome
(courier) chemically altered growth factors, other human-derived
and/or non-human derived growth factors and/or the like. In some
embodiments, the growth factors that are delivered to a subject's
skin tissue for hair growth purposes include, but are not limited
to, human growth factors, synthetic or laboratory-derived growth
factors and/or the like. In other embodiments, one or more other
substances can be delivered to the subject's skin, either in
addition to or in lieu of growth factors. For example, in some
embodiments, one or more of the following can be delivered to a
targeted area or portion of the subject's skin to help promote hair
growth: growth factors, amino acids (e.g., leucine, isoleucine,
valine, etc.), antioxidants, minoxidil, other antihypertensive
vasodilators, finasteride, dutasteride, ketoconazole,
spironolactone, flutamide, catechin, epicatechin, other
phytochemicals, carnitine, rejuvaplex, copper peptides, other hair
growth-stimulating agents, other pharmaceuticals and
non-pharmaceuticals, plant-derived products, cleansing or
pre-cleansing shampoos, other cleansing or pre-cleansing solutions
(e.g., salicylic acid, GlySal.TM. (glycolic acid and salicylic acid
mix), other acids, etc.), other natural and synthetic materials
and/or the like.
[0040] According to some embodiments, regardless of the exact
material(s) or substance(s) utilized or combination thereof, the
delivery of agents and/or other substances and materials can
advantageously assist with the growth of hair along a subject's
targeted skin surface. In some embodiments, the delivery of such
fluids and/or other materials can help improve the health of native
and/or translated hair, as desired or required.
[0041] By way of example, fluids and/or other materials can be
delivered to the targeted portion of a subject skin (e.g., the
subject's scalp) using a handpiece assembly identical or similar to
the one illustrated and discussed herein with reference to FIGS. 5
to 9. In other embodiments, any other device (e.g., handpiece
assembly) or method can be used to deliver one or more fluids to
targeted skin of a subject. In some arrangements, for instance, a
handpiece similar or identical to the one illustrated in FIG. 1
herein can be used.
[0042] FIG. 1 illustrates one embodiment of a handpiece assembly
100 configured for use with a skin treatment system. As shown in
FIG. 1, a handpiece assembly 100 can include a main body portion
110 configured to receive a tip 130 along its distal end 120. In
some embodiments, the tip 130 is removably attached to the distal
end of the main body portion 110. Alternatively, however, the tip
can be permanently attached to the main body portion 110, as
desired or required. The tip can include one or more abrasive
features, surfaces and/or the like that are configured to
selectively abrade skin when the handpiece assembly 100 is moved
relative to a subject's skin. For example, the tip can include one
or more posts, spiral members, other abrasive and/or sharp ridges
or features and/or the like. Therefore, the tip can be configured
to conduct the microdermabrasion of the targeted skin surface.
Additional details regarding possible tip options that can be
incorporated into any of the embodiments disclosed herein are
provided in U.S. patent application Ser. No. 11/392,348, filed on
Mar. 29, 2006 and issued as U.S. Pat. No. 8,048,089 on Nov. 1,
2011, the entirety of which is incorporated by reference herein and
made a part of the present application.
[0043] With continued reference to FIG. 1, the handpiece assembly
100 can be sized, shaped and otherwise configured to receive one or
more vials or cartridges 200. For example, as shown, the handpiece
assembly can include a recess or other opening into which a vial
200 can be placed and secured. Such vials or other containers 200
can include one or more fluids and/or other materials that can be
selectively delivered to the subject's skin surface during use in
order to promote hair growth.
[0044] In some embodiments, one or more materials can be
strategically embedded, impregnated, placed, stored and/or
otherwise disposed on one or more surfaces or areas of the tip or
other portion or component of the skin treatment system. Such
materials can comprise solids, semi-solids, other dried substances,
gels, concentrated solutions and/or the like. For example, such
materials can be provided in loose form (e.g., positioned on or
within a recess, other portion of the tip, within a cartridge or
other container, adhered to one or more surfaces, etc.), as a
tablet, capsule, pill, disc or other dissolvable solid, saturated
within a foam pad or other sponge-like material and/or the like.
Thus, in certain arrangements, water (e.g., distilled, tap water,
filtered, etc.), saline, other dilutants and/or other fluids which
are delivered to the tip can selectively dissolve, liquefy, melt,
soften, dilute or otherwise prepare the materials embedded,
impregnated and/or otherwise positioned on the tip, within a
cartridge or other container and/or on or within another portion or
component of a skin treatment system (e.g., handpiece assembly,
fluid line upstream of the handpiece assembly, etc.). Accordingly,
any desired hair growth materials or formulations can be
advantageously provided to the skin surface being treated, as
desired or required.
[0045] In addition, as illustrated in FIG. 1, the handpiece
assembly 100 can be connected to a vacuum. For example, the waste
conduit 180 of the handpiece assembly can be placed in fluid
communication with a suction or vacuum source (not shown) in order
to remove exfoliated skin, spent fluids, waste materials and/or
other substances away from the treatment surface. As noted above,
the handpiece assembly 100 can be configured to receive one or more
removable tips 130, which may be selected based upon the specific
procedure being performed, the desired result and/or any other
considerations. The distal portion 120 of the handpiece assembly
100 can include one or more O-rings 138 or other sealing members to
prevent undesirable leaks between the main body portion 110 and the
tip 130. Additional details regarding removable tips are provided
in U.S. patent application Ser. No. 12/832,663, filed on Jul. 8,
2010 and published as U.S. Publ. No. 2011/0082415 on Apr. 7, 2011,
the entirety of which is hereby incorporated by reference herein
(see, for example and without limitation, FIGS. 5B and 8A through
16B of the referenced application).
[0046] With continued reference to FIG. 1, the handpiece assembly
100 can be configured to receive one or more types of vials or
cartridges 200. For example, a vial 200 can include, without
limitation, a standard or non-standard vial, ampoule or any other
container. In some embodiments, hair growth agents and/or any other
treatment fluids or materials contained within the cartridge 200
can be drawn toward the tip 130 using one or more suction sources
(e.g., the vacuum source configured to remove waste materials from
the tip). In other embodiments, the fluids and/or other materials
contained within the cartridge (e.g., fluids and/or other materials
configured to promote and/or stimulate hair growth) gravity flow
toward the tip 130 or are conveyed with the help of a fluid
transfer device. The cartridge 200 can be selectively removed from
the handpiece assembly 100 when a desired volume or other amount of
serum or other material has been delivered to the tip 130.
[0047] In some embodiments, a vacuum in fluid communication with
the waste conduit 180 can be configured to remove waste materials
from the tip 130 and help deliver serums, other fluids and/or any
other materials from the vial or cartridge 200 to the tip 130. When
the tip 130 is positioned against the subject's skin, suction
created by the vacuum source can be transmitted to one or more
fluid channels or conduits of the handpiece assembly 100. Such a
suction force created within the corresponding channels or conduits
of the handpiece assembly can remain intact as long as the tip 130
is maintained against or substantially against the subject's skin.
Consequently, the suction force created by the vacuum source can be
transferred to one or more fluid delivery channels of the assembly
100, thereby transferring fluids and/or other materials from the
vial or other container toward the tip 130.
[0048] In some embodiments, serums, other fluids and/or other
materials can be delivered to the tip 130 (e.g., from a cartridge,
an external source, etc.) through one or more peripheral or other
non-centrally located channels, conduits and/or other lines or
fittings. For instance, in the handpiece assembly 100 illustrated
in FIG. 1, such fluids and/or other materials can be routed through
one or more internal channels of the assembly and/or waste conduits
of the tip. Thus, in some embodiments, one or more of the channels,
connectors and/or other hydraulic components may need to be
reconfigured to adequately place the non-centrally located delivery
openings of the tip in fluid communication with corresponding
delivery lines of the handpiece assembly 100.
[0049] According to certain embodiments, as illustrated in FIG. 2,
a vial, cartridge or other container 200 is placed in fluid
communication with a manifold system 400 that may comprise a
plurality of individual fluid conduits 410, 420, 430, 440. In turn,
one or more of these fluid conduits 410, 420, 430, 440 can be in
fluid communication with a separate container (not shown). For
example, in some embodiments, such fluid conduits can be in fluid
communication with containers of a tower system (see, e.g., FIGS.
9-11). In the illustrated embodiment, the individual fluid lines
410, 420, 430, 440 are in fluid communication with a main fluid
conduit 450, which connects to a nozzle 202 along a proximal end of
a vial or other container 200 secured within the handpiece assembly
100. One or more of the fluid conduits can comprise a valve 412,
422, 432, 442 or other flow control device or feature to
selectively regulate the transfer of fluids and/or other materials
(e.g., hair growth fluids and/or materials) to the handpiece
assembly 100. In the illustrated arrangement, the manifold system
400 comprises a total of four fluid branches. However, a system can
comprise more or fewer fluid branches (e.g., 1, 2, 3, 4, 5, 6, 7,
8, more than 8, etc.), as desired or required by a particular
application or use.
[0050] According to certain embodiments, one or more of the fluid
lines fluid conduits of the manifold system illustrated in FIG. 2
are configured to provide a serum, other treatment fluid and/or the
like, including fluids and materials that are adapted to promote
hair growth. Alternatively, however, one or more of the conduits
can be configured to receive water (e.g., distilled, tap water,
filtered, etc.), saline, other dilutants or dissolvents, other
fluids and/or the like to the handpiece assembly 100. As discussed
in greater detail herein, such fluids can be adapted to contact and
dissolve, dilute, liquefy, soften and/or otherwise mix with one or
more solids, gels and/or other materials positioned within or on
various surfaces or portions of the handpiece assembly 100 (e.g.,
tip). This can provide a convenient method of providing one or more
materials at the skin-tip interface and/or any other location where
such materials are desired or required.
Suction/Vacuum
[0051] In some arrangements, vacuum, suction or negative pressure
can be applied to a targeted skin surface (e.g., a subject's scalp)
to facilitate the transmission, infusion, diffusion and/or
progression of one or more treatment materials into skin surface,
to stimulate blood flow along or near the targeted skin surface
and/or to provide one or more other advantages or benefits.
Consequently, the effectiveness of a hair growth procedure and the
likelihood of success can be improved. Such vacuum can be applied
using a handpiece that is specially-designed to engage the skin and
provide such a vacuum force. For example, a handpiece that is
identical or similar to an embodiment disclosed in any of the
following applications can be used: U.S. patent application Ser.
No. 12/346,582, filed Dec. 30, 2008 and issued on Jan. 1, 2013 as
U.S. Pat. No. 8,343,116, U.S. patent application Ser. No.
11/392,348, filed Mar. 29, 2006 and issued on Nov. 1, 2011 as U.S.
Pat. No. 8,048,089, U.S. patent application Ser. No. 12/832,663,
filed Jul. 8, 2010 and issued on Aug. 26, 2014 as U.S. Pat. No.
8,814,836 and International Patent Application No.
PCT/US2014/024992, filed Mar. 12, 2014 and published on Sep. 25,
2014 as PCT Publ. No. WO 2014/151104. As noted herein, the
entireties of all of the foregoing are hereby incorporated herein.
The embodiments discussed herein with reference to FIGS. 1 and 2
provide example systems that utilize vacuum to assist in the
delivery of fluids and other treatment materials from one or more
containers (e.g., vials, bottles includes in a tower or manifold
system, etc.) to the skin interface.
[0052] The use of such handpieces and/or other devices or systems
can provide one or more benefits or advantages during a treatment
(e.g., hair growth promotion or strengthening) procedure. For
example, the delivery of suction or vacuum to the targeted skin
surface can facilitate blood flow to the targeted skin surface
(e.g., the superficial and/or deep layers or tissues at, near or
adjacent the targeted hair growth area). This can, in certain
circumstances, therapeutically benefit the targeted tissue to help
create an environment where the likelihood of hair growth can be
improved. In addition, the delivery of fluids and/or other
materials (e.g., growth factors, amino acids, antioxidants,
Minoxidil, other antihypertensive vasodilator agents, other hair
growth-stimulating agents, other natural or synthetic materials,
etc.) deeper into the targeted skin tissue can be further enhanced
by the use of vacuum or suction.
Pressure & Pulsing and Positive Pressure with Vacuum
[0053] In some embodiments, the infusion or transfer of fluids
within targeted skin tissue can be enhanced using the delivery of
pressure (e.g. the application of force, either constant or
intermittent) and/or mechanical pulsing of the tissue surface. For
example, a handpiece assembly and/or other device or system can be
used to deliver pulsed air to a targeted skin tissue of a subject
(e.g., the subject's scalp, other skin region where hair growth is
desired, etc.). In some embodiments, the use of pressure, pulsing
and/or similar technologies can assist with the delivery of
treatment fluids and/or substances deeper into skin tissue to
facilitate a treatment procedure (e.g., a hair growth promotion
protocol or method). In such arrangements, the use of mechanical
force (e.g., via pressure, pulsing, etc.) can help push or drive
treatment fluids and/or other substances delivered to or near the
tip of a handpiece or other device or system deeper into skin
tissue. In some embodiments, the ability to deliver at least a
portion of treatment fluid and/or other materials deeper into skin
tissue can facilitate the overall process and help promote health
and hair growth ability in such tissue.
[0054] According to some arrangements, a device or system that is
configured to deliver air at a desired pulse rate or frequency can
be used to help "drive" treatment fluids and/or other materials
deeper into a targeted skin surface (e.g., the subject's scalp).
Additional details regarding the use of pulsing (e.g., air-based
pulsing) are provided in International Patent Application No.
PCT/US2014/024992, filed Mar. 12, 2014 and published on Sep. 25,
2014 as PCT Publ. No. WO 2014/151104, the entirety of which is
hereby incorporated herein.
[0055] FIGS. 3A to 4E illustrate non-limiting embodiments of
handpiece assemblies that are configured to provide one or more
fluids and/or other treatment materials (e.g., hair growth
promoting agents) to a skin interface in conjunction with air
delivery (e.g., pulsing) and/or needling.
[0056] According to some embodiments, as discussed herein, the
effectiveness of performing a treatment procedure (e.g., hair
growth stimulation procedure) can be enhanced by the delivery of
mechanical agitation to the skin surface being treated. For
example, air or other fluid can be selectively pulsed or otherwise
delivered to the skin surface at the same time that exfoliation
and/or treatment fluid delivery occurs. In other embodiments, other
forms of mechanical energy (e.g., acoustic energy, needle
penetrations, etc.) can be used, either in lieu of or in addition
to fluid delivery. This can be conducted concurrently with a skin
treatment procedure and/or before or after a skin treatment
procedure as desired or required. As noted above, in some
embodiments, it may be beneficial to provide air or other fluid to
the skin surface being treated. The air can be delivered at a
particular flowrate, pressure, intensity, pulsing rate or frequency
and/or time duration to help achieve a particular effect on the
skin surface. For example, air or other fluid can be pulsed onto
the skin during, before and/or after a microdermabrasion procedure
to promote and facilitate the transfer of serums, other liquids
and/or other materials at least partially into the subject's skin
tissue. In some embodiments, air pulsing can comprise square wave
pulsing (e.g., having sequential air delivery and no air delivery
phases, one after another, etc.).
[0057] In some embodiments, air is delivered through the air
delivery passage in individual puffs. Accordingly, depending on
their volume, intensity, pressure and/or other properties, such
puffs can help exert an intermittent force along the subject's
skin. As noted above, such mechanical or pneumatic agitation of the
skin can provide one or more benefits. For example, the resulting
force or pressure on the skin can help drive serums, liquids and/or
other substances being delivered to the tip (e.g., via the fluid
delivery passage) deeper into the skin tissue. The repetitive
agitation created by the air puffs can also help loosen dirt, oils
and/or other unwanted materials from the pores along the skin
surface being treated.
[0058] A handpiece assembly configured to deliver air or other gas
during a skin treatment procedure can be configured to allow a user
to adjust the manner in which air is delivered through one or more
air delivery passages and/or the amount of negative pressure that
is applied by the vacuum source through the suction passage (e.g.,
or the amount negative pressure that is realized along the tip). In
some embodiments, the negative pressure within the suction passage
is sufficiently high to maintain contact between the subject's skin
and the peripheral and inner lips during use. This can help
maintain a steady and consistent flow of treatment fluids to the
working surface while a skin surface (e.g., a subject's scalp or
other skin region where hair growth is desired) is exfoliated or
otherwise treated. A sufficiently high vacuum along the tip can
also help ensure that the lips will not lose contact with the skin
surface as air is delivered (e.g. in puffs) to the skin
surface.
[0059] According to some embodiments, one or more needles or other
piercing members can be used to agitate and/or penetrate certain
areas or regions of the subject's skin, before, during or following
a microdermabrasion or other skin treatment procedure. The needles
or other penetrating members can be moved in and out of adjacent
skin tissue over a period of time. Consequently, a plurality of the
small diameter passages can be created in the targeted skin tissue,
at least temporarily. Such passages can allow serums, other
treatment agents and/or other substances that are delivered or
otherwise applied to the skin to be advantageously carried deeper
into the skin tissue.
[0060] FIGS. 3A-3E illustrate various views of another embodiment
of a skin treatment device 3200 comprising a main body 3210 and a
tip 3240 positioned along the distal end of the main body. In some
embodiments, the tip 3240 can be removably secured to the main body
3210. As illustrated in frontal view of FIG. 3B, the tip 3240 can
comprise an outer or peripheral lip 3260 that is configured to
contact the skin surface (e.g., a subject's scalp) when the device
3200 is properly positioned relative to the subject's skin. The tip
3240 can additionally include an interior lip or ridge 3252 that is
also configured to contact the skin surface being treated (e.g.,
simultaneously with the outer or peripheral lip or ridge 3260.
[0061] With continued reference to FIG. 3B, the generally annular
area defined between the outer and inner lips or ridges 3260, 3252
can include one or more openings or ports. For example, as shown,
the annular area can include one or more vacuum or suction ports
3242. In some embodiments, such ports 3242 comprise posts or other
members that extend above the bottom surface of the annular region.
As shown in FIG. 3B, the vacuum or suction ports 3241 can be
strategically positioned adjacent or near (e.g., immediately
surrounding) the inner ridge 3252. Such a configuration can assist
to maintain contact between the lips or ridges 3260, 3252 and the
subject's skin surface when the device 3200 is in use. The ability
to consistently and adequately maintain contact between the tip and
the subject's skin can be challenging when air or other fluid is
being pulsed through the central opening 3256 of the tip, during
use. As can be appreciated, the delivery of positive air pressure
during pulsing can urge the tip (e.g., especially the inner lip
3252 and surrounding structures) to lose contact with the skin
(e.g., the subject's scalp or other skin region where hair growth
is desired). Therefore, the system can be configured to provide
sufficient suction or vacuum along, near or adjacent the pulsing
port 3256 to ensure that proper skin contact is maintained during
use of the device. In other configurations, the suction ports or
openings 3242 can be flush, generally flush and/or recessed
relative to the bottom surface of the annular region of the tip.
Further, the shape, size, orientation, spacing, location, quantity
and/or other characteristics of the ports or openings 3242 can be
different than illustrated in FIG. 3B, as desired or required.
[0062] As illustrated in FIG. 3B, the annular region defined
between the two lips or ridges 3260, 3252 can also include one or
more fluid delivery ports 3246 and/or additional vacuum or suction
ports 3248. In one embodiment, as illustrated in FIG. 3B, a single
fluid delivery port 3246 is generally opposite of a vacuum or
suction port 3248, facilitating in the delivery of a treatment
fluid across a larger surface area of the skin being treated. In
other embodiments, the quantity, orientation, location, size, shape
and/or other details about fluid delivery ports and/or additional
suction ports can vary.
[0063] With continued reference to FIG. 3B, the region defined
within the interior of the inner lip 3252 includes an opening 3256
that is in fluid communication with one or more passages that
extend through an interior of the device 3200. As discussed in
greater detail herein, such an opening 3256 can be used to
selectively provide pulsed air or other fluid to the skin during a
treatment procedure.
[0064] As shown in FIGS. 3B and 3C, the pulsing opening 3256 of the
tip can be placed in fluid communication with a pulsing fluid
connector 3204 toward the distal or rear portion of the device 3200
(e.g., via one or more interior lumens, conduits or other
passages). Such a connector 3204 can be coupled to a pulsed air
source, either directly or indirectly, to selectively deliver air
to the tip and the skin surface at a desired frequency, duty cycle,
volume and/or the like. As discussed, the delivery of such pulsed
air or other fluid can assist with a deeper penetration of
treatment fluids into the skin surface, thereby enhancing a skin
treatment procedure (e.g., a hair growth procedure). For example,
in some embodiments, the mechanical agitation of the pulsing of air
can drive, push or otherwise force treatment fluids that have been
delivered to the skin surface deeper into the skin.
[0065] According to some embodiments, one or more parameters
related to the pulsing of air or gases in the device 3200 can be
adjusted by a user, as desired or required. For example, in some
embodiments, the high and low pressure levels during a pulsing
sequence can be modified. As noted above, the low pressure level
can be zero, positive or above zero, or negative or below zero
(e.g., with respect to atmospheric pressure). Thus, in some
embodiments, air is pulsed between positive and negative (e.g.,
suction) pressures during a specific cycle. In other embodiments,
both high and low pressure levels can be above atmospheric. Thus, a
pulsing cycle does not need to include a vacuum or suction phase.
In other embodiments, the low pressure level is zero or around
zero. These pulsing options can be applied to any embodiments
disclosed herein that are configured or can be configured to be
used with pulsed air delivery to the skin interface (e.g., for
improved serum penetration into the targeted skin surface, such as
a subject's scalp).
[0066] Although not illustrated in the embodiment of FIGS. 3A-3E, a
tip 3240 that is configured to permit the pulsing of air along a
skin interface can additionally comprise one or more abrading
members (e.g., posts, spiral, ridges, brushes, sharp edges,
roughened surfaces, etc.). Thus, in some embodiments, while the
device 3200 is activated (e.g., during the delivery of pulsed air
and/or during the maintenance of suction through corresponding
vacuum ports, etc.), the user can selectively translate or move the
tip of the device relative to the targeted skin surface to at least
partially abrade and/or otherwise treat the skin (e.g., scalp,
other skin region where hair growth is desired, etc.).
[0067] However, in other embodiments, the device 3200 comprises a
non-abrading tip 3240 for the purpose of driving serums and/or
other fluids deeper into the skin. This can be performed as part of
a preliminary, intermediate (e.g., secondary) or follow-up (e.g.,
tertiary) step in a treatment process or protocol, as desired or
required. For example, in some embodiments, such a non-abrading
device is used (and the corresponding method is utilized) following
an abrading or preparatory procedure, step or phase.
[0068] With continued reference to FIGS. 3A-3E, device 3200 can be
configured to be placed in fluid communication with one or more
serums and/or other treatment fluids contained in a cartridge C. As
shown, such a cartridge can be secured within a corresponding
recess of the handheld device 3200, which in the depicted
arrangement is located along the distal end of the device. In other
embodiments, however, the device can include a port along its
distal end (or along any other portion). Such a port (not shown in
the illustrated arrangement) can be placed in fluid communication
with a main fluid delivery line. In some embodiments, for example,
such a main fluid delivery line or conduit can be configured to
deliver serums and/or other fluids from a manifold system, such as
the one disclosed herein with reference to FIG. 2.
[0069] As shown in FIG. 3C, the handheld device 3200 can include
additional ports 3202, 3204 for connecting to a vacuum source
and/or a pulsed air source. Such fluid sources can be separate from
the treatment system or may be at least partially incorporated into
the system, as desired or required. In some embodiments, at a
minimum, the vacuum and pulsed air sources are in data
communication with a control module or other controller to permit a
user of the device to advantageously regulate the level of suction
and/or the level of pulsing during use.
[0070] According to some embodiments, the pulsed air concepts can
be combined with a movable needle assembly that is configured to
selectively penetrate skin. A system that combined needle
penetrations with pulsed air delivery can provide more enhanced
(e.g., deeper) infusion or penetration of serums and/or other
liquids being delivered to the skin surface being treated (e.g., a
subject's scalp). One embodiment of a combination needle
penetration and pulsed air delivery device 3300 is illustrated in
FIGS. 4A-4E. As discussed above with reference to FIGS. 3A-3E, the
device 3300 can include an inner lip or ridge 3352 and an outer lip
or ridge 3360. Such lips or ridges 3352, 3360 can be shaped, sized
and otherwise configured to contact a skin surface when tip 3340 of
the device 3300 is properly positioned against a subject.
[0071] With reference to front view of the tip in FIG. 4B, as with
other device embodiments disclosed herein, the area or space
extending between the inner and outer lips or ridges 3352, 3360 can
be configured to receive one or more treatment fluids when the
device is in use. For example, when the lips or ridges 3352, 3360
contact a skin surface and a vacuum or suction source is activated,
serum and/or other liquid from a fluid source (e.g., a cartridge C,
as illustrated in FIGS. 4A-4E, a main fluid conduit that is coupled
to a manifold system, etc.) can be delivered through one or more
fluid delivery ports 3346 located between the ridges 3352, 3360.
Spent fluid and/or other debris can be removed from the tip and the
skin/device interface through a vacuum opening 3348, which, in the
illustrated arrangement, is also located between the ridges 3352,
3360. As discussed above with reference to the device of FIGS.
3A-3E, the fluid delivery port 3346 and the suction or vacuum port
3348 can be spaced apart from each other by a desired separation
distance, which can help ensure that the serums and/or other fluids
that are delivered to the skin pass along at least a portion of the
tip before being removed. In some embodiments, this can provide for
longer contact time between the serums and/or other liquids and the
skin, which can result in a better treatment outcome.
[0072] With continued reference to FIG. 4B, the inner ridge or lip
3352 can include one or more openings or passages 3356 that are
adapted to provide pulsed air to the region defined by the ridge
3352. In the depicted embodiment, there are three separate openings
or opening sections 3356 contained within an interior of the inner
ridge or lip 3352. However, in other embodiments, the inner ridge
can include more or fewer openings or opening sections, as desired
or required. Pulsed air or other gas can be selectively provided
through such openings 3356 to create a desired puffing or
air-driven effect on the skin, as discussed in greater detail
herein with reference to other air pulsing arrangements. In some
embodiments, in order to maintain proper contact between the inner
and outer ridges 3352, 3360 and the skin surface of the subject
during use, one or more vacuum or suction ports 3342 can be
strategically positioned along or near the inner ridge. Thus, the
use of such suction can help prevent or reduce the likelihood of
disengagement between the inner ridge 3352 and the skin surface
being treated during use.
[0073] As shown in FIGS. 4A-4E, the device can additionally include
a movable needle assembly 3370 within an interior portion of the
tip 3340. In the illustrated embodiment, a single movable needle
assembly is positioned along a central portion of the tip (e.g.,
within an interior of the inner ridge or lip 3352. However, in
other embodiments, the size, shape, location, quantity and/or the
details regarding the movable needle assembly 3370 can vary, as
desired or required. The needle assembly can include a plurality of
needles 3372 that extent outwardly (e.g., in a distal
direction).
[0074] According to some embodiments, the needle assembly 3370 can
be configured to reciprocate between proximal and distal positions
during use. In some embodiments, the reciprocation or other
movement of the needle assembly 3370 is accomplished pneumatically
or mechanically. For example, in one embodiment, an air or other
fluid line is coupled, at least partially, with a receptacle or
housing in which the needle assembly 3370 is positioned. The
delivery of positive and/or negative fluid pressure relative to the
movable needle assembly 3370 (e.g., and/or a related receptacle or
housing) can be used to move the needle assembly 3370 in a desired
manner. In some embodiments, the movable needle assembly 3370 can
be spring loaded (e.g., using a spring or other resilient member or
assembly S located within the handpiece. Thus, in such
configurations, the needle assembly 3370 can be resiliently biased
in a retracted (or proximal) orientation by the spring or other
resilient force. The exertion of a pressure or force on the needle
assembly 3370 (e.g., using the selective delivery of air relative
to the assembly 3370) can help displace the needle assembly 3370
away from its resiliently retracted position to a more distal
orientation against the spring or biasing force. Once the force on
the movable needle assembly is terminated, the needle can assume
its retracted, proximal position.
[0075] According to some embodiments, the extent to which the
needle assembly is moved distally can be precisely controlled. For
example, the degree to which the needle assembly is advanced can
depend on the spring force of the spring or other resilient member,
the amount of force that is applied to the assembly 3370 and/or the
like. Accordingly, such parameters can help control the depth of
needle penetration into the scalp or other skin surface caused by
the needle assembly 3370. Depth of needle penetration and the
resulting effect on the subject's skin tissue (e.g., a subject's
scalp) can also be altered using other methods. For example, the
device 3300 can be provided to a user with a variety of tip
options, each of which has a different maximum penetration distance
(e.g., by varying the length, diameter, sharpness and/or other
characteristics of the needles 3372 included in the assembly 3370).
In some embodiments, the user is permitted to alter the maximum
needle penetration distance by manipulation the tip and/or needle
assembly. For example, in some embodiments, the height of the lips
or ridges can be adjusted. In other arrangements, the user can
change the orientation (e.g., depth) of the needle assembly within
the handpiece to effectively modify the penetration depth.
[0076] In some embodiments, a user presses a button or manipulates
one or more other controllers or features (e.g., switch, foot
pedal, etc.) to selectively deploy the needle assembly 3370
distally (e.g., toward the skin surface). For example, in a
pneumatically-controlled needle assembly configuration, the user
can press a button to permit pressurized air to enter into the
corresponding conduit of the handpiece so as to exert a force on
the needle assembly. As a result, the needle assembly can be moved
toward the skin. If sufficient force is applied to the needle
assembly, the needle assembly may move sufficiently far (e.g., in
the distal direction) to engage and at least penetrate an adjacent
skin surface of the subject.
[0077] In other embodiments, the manipulation of a button or other
controller can actuate a mechanically-generated force on the needle
assembly 3370 to move the assembly distally against a spring or
other resilient force. In yet other arrangements, the needle
assembly is not resiliently biased (e.g., does not include a spring
or other resilient member). For example, the movable assembly can
moved between a proximal and a distal position using a motor, gear
and/or the like. Regardless of the manner in which the needle
assembly is moved toward and away from the skin surface of the
subject, in some arrangements, the assembly can be moved along
several different proximal/distal positions. In some embodiments,
available positions can be distinct (e.g., only at certain
distances) or continuous (e.g., along any position between fully
retracted and fully extended), as desired or required.
[0078] In some embodiments, during use, the movable needle assembly
3370 can be actuated (e.g., to move distally to and through a skin
surface) only when the treatment device 3300 is not being
translated or moved relative to the subject's skin (e.g., a
subject's scalp). Such a method of using these devices can help
avoid undesirable harm to the subject. The use of needles to create
passages within the one or more layers of skin being treated can
provide additional benefits to the subject. For example, serums
and/or other fluids delivered and/or otherwise located along the
tip of the device can penetrate the subject's skin to a deeper
extent. Such advantages and benefits can be further enhanced by the
simultaneous air pulsing on the skin tissue.
[0079] As shown in FIG. 4C, the device 3300 can include additional
ports 3302, 3304, 3306 for connecting to a vacuum source (e.g., to
the suction port), an air supply line (e.g., to the movable needle
assembly; for selectively pneumatically actuating the assembly)
and/or a pulsed air source (e.g., for providing pulsed air to the
tip of the device). Such fluid sources can be separate from the
treatment system or may be at least partially incorporated into the
system, as desired or required. In some embodiments, at a minimum,
the vacuum, air supply and pulsed air sources are in data
communication with a control module or other controller to permit a
user of the device to advantageously regulate the level of suction,
position of the needle assembly and/or the level of pulsing during
use. In some embodiments, the button or other controller associate
with movement of the movable needle assembly can be coupled or
incorporated into a valve structure in order to regulate the
delivery of air or another gas to the assembly.
[0080] According to some embodiments, the needles 3372 of the
needle assembly 3370 can be solid or hollow. In some embodiments,
the needle diameter is 0.001-0.050 inches (e.g., 0.010 inches,
0.001-0.005, 0.005-0.010, 0.010-0.020, 0.020-0.030, 0.030-0.040,
0.040-0.050 inches, diameters between the foregoing ranges, etc.).
In other embodiments, the needle diameter is less than 0.001 inches
or greater than 0.050 inches (e.g., 0.050-0.060, 0.060-0.070,
0.070-0.080, 0.080-0.090, 0.090-0.100 inches, diameters between the
foregoing ranges, greater than 0.100 inches, etc.). In some
embodiments, the needle length is 0.05-5 mm (e.g., 0.5-2.5,
0.05-0.1, 0.1-0.2, 0.2-0.3, 0.3-0.4, 0.4-0.5, 0.5-0.6, 0.6-0.7,
0.7-0.8, 0.8-0.9, 0.9-1.0, 1-2, 2-3, 3-4, 4-5 mm, lengths between
the foregoing ranges, greater than 5 mm, etc.).
[0081] In any of the embodiments disclosed herein that incorporate
a needle assembly specially or any needle penetration technologies
generally, the needles can be solid and/or hollow. In some
embodiments, the needles can be configured to be selectively heated
or cooled. For example, in one embodiment, the needles can be
heated using resistive heating (e.g., via electrical energy,
radiofrequency energy, etc.), using vapor (e.g., hot vapor) or
similar techniques, thermoelectric devices and/or the like.
[0082] In any of the treatment embodiments disclosed herein, one or
more pulsing parameters can be modified to create a desired effect
on the subject's skin. For example, as noted above, the high and
low pulse pressures can be adjusted. Further, in some embodiments,
the duty cycle, frequency, air flowrate and/or other properties can
be modified, as desired or required. For example, the duty cycle
can be modified between 20 and 60% (e.g., 20-25, 25-30, 30-35,
35-40, 40-45, 45-50, 50-55, 55-60%, duty cycles between the
foregoing ranges, etc.). In other embodiments, the duty cycle for
the pulsed air system is greater than 60% (e.g., 60-70, 70-80,
80-90, 90-95%, duty cycles between the foregoing, greater than 95%,
etc.) or less than 20% (e.g., 0-5, 5-10, 10-15, 15-20%, duty cycles
between the foregoing ranges, etc.).
[0083] According to some embodiments, for any of the arrangements
disclosed herein, the frequency of the pulsed air can vary between
2 and 15 Hz (e.g., 2-3, 3-4, 4-5, 5-6, 6-7, 7-8, 8-9, 9-10, 10-11,
11-12, 12-13, 13-14, 14-15 Hz, frequencies between the foregoing
ranges, etc.). In other embodiments, however, the frequency of
pulsed air can be less than 2 Hz (e.g., 0-0.5, 0.5-1, 1-1.5, 1.5-2
Hz, frequencies between the foregoing ranges, etc.) or greater than
15 Hz (e.g., 15-20, 20-25, 25-30, 30-40, 40-50 Hz, frequencies
between the foregoing ranges, greater than 50 Hz, etc.).
[0084] In other embodiments, an air-based pressure or force along
the distal end of a handpiece or other device can be applied to
push at least a portion of a treatment fluid or other material
deeper into the skin surface. For example, a continuous delivery of
air, a hammering or other mechanical impact device and/or the like
can be used to help accomplish deeper infusion of fluids and/or
other materials into the skin, promote blood flow and/or provide
one or more other effects that may promote or otherwise facilitate
hair growth along the targeted skin tissue, as desired or
required.
[0085] In some embodiments, the pulsing (e.g., pneumatic,
mechanical, etc.) along a distal end of a handpiece or other system
can comprise alternating amounts of positive pressure (e.g.,
relative to atmospheric). Alternatively, the pulsing can include a
first stage where a positive pressure is created (e.g., by air
deliver, by mechanical or pneumatic impact, etc.) and a second
stage where a negative pressure (or vacuum) is created. Such first
and second stages can be alternates according to a desired or
required frequency, which may be adjustable by a user.
[0086] In other arrangements, a handpiece or other treatment device
or system is configured to simultaneously (as opposed to
sequentially, as described in the above embodiments) deliver both
positive and negative (vacuum) pressure to the skin interface. For
example, in some embodiments, the distal end or tip of a handpiece
assembly can be configured to separately create one or more
positive pressure zones and one or more negative pressure (or
vacuum) zones along its interface with the adjacent skin tissue of
the subject being treated. Additional details related to these
embodiments are disclosed in International Patent Application No.
PCT/US2014/024992, filed Mar. 12, 2014 and published on Sep. 25,
2014 as PCT Publ. No. WO 2014/151104, the entirety of which is
incorporated by reference herein.
Improved Handpiece Designs
[0087] In some embodiments, as illustrated in FIG. 5, a handpiece
assembly 2010 can include a flexible engagement member or shroud
2020 located along the distal end of the handpiece assembly 2010.
As shown in FIG. 5, the engagement member 2020 can be secured or
otherwise coupled to a tip 2016 that is configured to be removably
secured to the distal end of the main body portion 2012 of the
assembly 2010. In other embodiments, however, the engagement member
2020 and/or the tip 2016 can be fixedly secured to the main body
portion 2012 of the handpiece assembly 2010. In yet other
configurations, the engagement member 2020 can be sized, shaped and
otherwise adapted to be removably or fixedly coupled to the main
body portion 2010 (e.g., with or without a tip), as desired or
required. In several embodiments, the main body portion 2010, the
tip 2016 and/or the engagement member 2020 can form a unitary or
monolithic structure. For example, some or all of the various
components of the handpiece assembly 2010 can be combined into a
single component or structure.
[0088] Regardless of its exact structure and/or design, the
engagement member or shroud 2020 can be configured to engage a
portion of a subject' skin and at least temporarily seal thereto.
For example, in some embodiments, the engagement member 2020 can be
configured to engage one or more contoured portions of a subject's
scalp, face or other skin surface being treated. The engagement
member 2020 can comprise one or more materials and/or features or
configurations that facilitate the distal end of the engagement
member 2020 contacting and adapting to the targeted skin surface.
For example, the engagement member 2020 can comprises rubber (e.g.,
silicone rubber) and/or other elastomeric materials. As shown in
FIG. 5, the engagement member 2020 can include one or more bellows
or other portion, feature, component and/or configuration that is
adapted to facilitate deformation of the engagement member 2020
such that it can contact and engage a targeted skin surface of a
subject (e.g., a subject's scalp, face, etc.), as desired or
required.
[0089] With continued reference to FIG. 5, the engagement member
2020 can comprises one, two or more (e.g., 3, 4, 5, more than 5,
etc.) bellows or other collapsible members 2028. As noted herein,
the bellows or other collapsible members can be configured to
accommodate for a particular degree of irregularity along the
distal end (e.g., along the end that is configured to contact and
engage a subject's tissue, such as a scalp or face). In some
embodiments, however, as illustrated in FIG. 9, the engagement
member 2120 does not comprise any bellows or other collapsible
members. Further, the engagement member or shroud 2020 can be
configured to provide a desired level of rotation between the
adjacent main body portion 2012 of the handpiece 2010 during use.
In other words, in some arrangements, depending on the length and
flexibility of the engagement member 2020, the engagement member
2020 can permit angles between 0 and 70 degrees (e.g., 0-10, 10-20,
20-30, 30-40, 40-50, 50-60, 60-70 degrees, angles between the
foregoing ranges, etc.) between the longitudinal axis of the main
body portion 12 and an axis perpendicular to the skin surface being
treated (and thus, a plane forming the distal end of the engagement
member), when the handpiece assembly is in use.
[0090] FIGS. 6 and 7 illustrate an embodiment of a handpiece
assembly comprising an engagement member or a shroud 2020 being in
use. Specifically, these figures show the engagement member 2020
during two different stages of operation for a handpiece assembly
2010 that is configured to provide a pulsed stream of fluid (e.g.,
air) to the distal end and to also provide a vacuum or suction
force to the distal end. As depicted in FIG. 6, the engagement
member or shroud 2020 is in a normal state, wherein its bellows
2028 are in an expanded configuration. In FIG. 7, the bellows 2028
are compressed or collapsed relative to each other. As discussed
herein, such a collapse can be as a result of a vacuum force
delivered to the interior space defined by the engagement member
2020, due to the user pushing or urging the handpiece assembly 2010
toward the targeted skin surface S (e.g., the scalp or face of a
subject) and/or due to any other reason. According to some
embodiments, the engagement member or shroud 2020, due to, e.g.,
the bellows, the use of flexible materials and/or the like, can be
configured to collapse by 20 to 80% (e.g., 20-30, 30-40, 40-50,
50-60, 60-70, 70-80%, percentages between the foregoing, etc.) of
its normal expanded length during use, as desired or required.
[0091] According to some embodiments, the engagement member or
shroud 2020 can be configured to attach to existing handpiece tips.
However, in other embodiments, the engagement member 2020 is
configured to be provided together with the tip or is configured to
be provided with the main body portion of a handpiece assembly
(e.g., such that the handpiece assembly and the engagement member
2020 form a unitary or monolithic structure). Regardless of its
exact configuration and incorporation into the handpiece assembly,
the distal engagement member or shroud 2020 can advantageously
compensate for and adapt to variations in the shape of a person's
scalp (or other targeted skin surface, e.g., facial regions) and
for variations in targeted skin surface shapes between individuals
being treated.
[0092] As discussed herein, in the embodiment illustrated in FIG.
5, the engagement member 2020 can be a separate component that
attaches (e.g., fixedly or removably) to a tip 2016. In other
arrangements, however, the tip 2016 can be manufactured with the
engagement member or shroud 2020, such that the tip 2016 is
configured to form a unitary or monolithic structure with the
engagement member 2020. The engagement member or shroud 2020 can be
positioned or otherwise secured to any tips disclosed herein,
including tips that are described and illustrated in applications
that are incorporated by reference herein. For example, the
engagement member can be coupled to tips that include both fluid
delivery and suction ports, tips that include one or more abrasive
structures (e.g., spiral members, posts, etc.) or abrasive
surfaces, tips that are configured to provide air to the skin
surface being treated (e.g., in a pulsed or non-pulsed manner) in
addition to providing suction and fluid delivery to the skin
surface, tips with or without needles, tips that include treatment
materials (e.g., in solid, semi-solid, gel, other non-liquid forms,
etc.) along the tip, such that water or other liquid delivered or
otherwise present along the skin-tip interface will cause such
treatment materials to dissolve and be released to the skin
surface, etc. The tips from one or more of the following can be
used together with an engagement member or shroud: U.S. patent
application Ser. No. 12/346,582, filed Dec. 30, 2008 and issued on
Jan. 1, 2013 as U.S. Pat. No. 8,343,116, U.S. patent application
Ser. No. 11/392,348, filed Mar. 29, 2006 and issued on Nov. 1, 2011
as U.S. Pat. No. 8,048,089, U.S. patent application Ser. No.
12/832,663, filed Jul. 8, 2010 and issued on Aug. 26, 2014 as U.S.
Pat. No. 8,814,836 and International Patent Application No.
PCT/US2014/024992, filed Mar. 12, 2014 and published on Sep. 25,
2014 as PCT Publ. No. WO 2014/151104.
[0093] In embodiments where the engagement member or shroud 2020 is
secured (e.g., fixedly or removably) to the tip (or directly to the
main body portion or other component of the handpiece assembly),
the engagement member or shroud 2020 can be secured using one or
more attachment methods or devices. For example, the engagement
member 2020 can be secured to the tip, main body portion and/or any
other portion or component of the handpiece assembly 2010 using a
press fit or friction fit connection, adhesives, a threaded
connection, one or more fasteners, welding and/or the like, as
desired or required.
[0094] As noted above, the attachment can comprise one or more
soft, flexible materials (e.g., silicone rubber, foam, latex,
vinyl, other types of rubbers and/or elastomeric materials, other
natural and/or synthetic materials that are flexible, etc.) that
are configured to conform to the surface of the scalp or other
generally uneven or irregular skin surface being treated (e.g.,
facial skin tissue, neck, arms, legs, etc.). In some embodiments,
the distal end of the engagement member or shroud 2020 is
configured to form a seal between its peripheral member or portion
and the adjacent targeted skin surface during use.
[0095] FIG. 8 illustrates an interior view of the engagement member
or shroud 2020 that is secured to a tip configured to provide a
suction force and fluid delivery to the tip, as well as a separate
air stream to the tip (e.g., either in a pulsed or non-pulsed
manner). For example, such tips are discussed in greater detail in
U.S. Publ. No. 2014/0343574 (see, e.g., FIGS. 4 to 5C) and PCT
Publ. WO/2014/151104 (see, e.g., FIGS. 4 to 5C and FIGS. 22A to
23E), both of which are incorporated by reference herein and made
part of the present application.
[0096] In embodiments, such as the one illustrated in FIG. 8, the
handpiece assembly is configured to provide fluid delivery (e.g.,
water, other serums and treatment materials, etc.) to the skin
surface being treated, e.g., via one or more passages within and/or
exterior to the main body portion and/or any other component of the
assembly, as desired or required. As noted herein, the embodiment
of FIG. 8 is also configured to provide a separate air stream that
is configured to provide a force (e.g., continuously or
intermittently) to the skin surface being treated. In some
embodiments, such a stream of positive air pressure can facilitate
the movement of fluids delivered or otherwise located along the
skin surface being treated deeper into the tissue. Such techniques
that help deliver fluids deeper into skin tissue can facilitate a
skin treatment procedure and provide greater benefits to the
subject being treated.
[0097] In embodiments, such as the one illustrated in FIG. 8, where
a vacuum is created along the distal end of the handpiece assembly
(e.g., and thus, at least partially within an interior of the
engagement member or shroud 2020, the engagement member or shroud
2020 can be configured to constantly maintain a seal with adjacent
tissue during use. For example, such a seal can be maintained
despite the delivery of fluids to the skin surface, despite the
delivery of a separate air stratum to the skin surface, despite the
intermittent nature of the suction force created within the
interior of the engagement member 2020 and/or despite any other
factors or considerations. In other embodiments, however, the
engagement member or shroud 2020 is configured to intermittently
lose contact and lose the seal with the adjacent skin surface.
Regardless of the exact manner in which the handpiece assembly, the
engagement member or shroud 2020 and/or other components or
features of the system are configured, the use of an engagement
member or shroud 20 can facilitate making and maintaining contact
with a variety of skin surfaces (e.g., irrespective of the
irregularity of the skin surface). Relatedly, the engagement member
2020 can facilitate capturing and removing fluid from the skin
surface being treated, thereby providing for a neater, less messy
procedure.
[0098] As noted above, the engagement member or shroud can be
shorter (e.g., include fewer bellows or other collapsible members
than the embodiment of FIG. 5, or include no bellows or collapsible
members). Such an arrangement for the engagement member 2120 is
illustrated in FIG. 9. In some embodiments, such an engagement
member or shroud 2120 can be used where the irregularity of the
targeted scalp or other skin surface is reduced (e.g., the skin
surface is more planar). In some embodiments, a user may prefer to
use a shorter engagement member or shroud 120, such as the one
illustrated in FIG. 9, for one or more reasons, e.g., to provide
more directed control of the handpiece assembly vis-a-vis the skin
surface, to provide less clearance between the tip and the skin
surface and/or for any other reason or purpose, as desired or
required.
[0099] As noted above, the engagement member or shroud can be used
with any type of tip and/or in any type of skin treatment
procedure. For example, a handpiece assembly can be provided with
an engagement member or shroud for use in a hair growth procedure.
For example, the engagement member can facilitate the delivery of
hair growth agents deeper into the scalp, either before, during or
after one or more other hair growth procedures or steps (e.g., hair
transplant delivery, needling, abrasion, etc.). For example, in
some embodiments, the use of the engagement member or shroud can
help drive one or more treatment materials or other components
deeper into the scalp or other targeted surface. Such materials
and/or other components, include, without limitation, amino acids,
antioxidants, Minoxidil, other antihypertensive vasodilator agents,
other hair growth-stimulating agents, other natural or synthetic
hairgrowth materials, skin tightening agents, platelet-rich plasma
(PRP), exfoliation agents, peptides, bleaching agents, anti-acne
agents, human growth factors, cytokines, soluble collagen,
antioxidants, matrix proteins, Epicatechin, Catechin and/or other
phenols and/or other anti-oxidants, neurotoxins, serums, salicylic
acid, other anti-acne acids and materials, microcapsules, capsules,
other time-release products and substances, water (e.g., distilled,
tap water, filtered, etc.), saline, other dilution agents,
dilutants or dissolvents, vitamins, chemical exfoliation agents,
lotions, soothing agents, brightening or lightening agents,
peptides, peeling agents, acids, anesthetics, medicants, other
non-active or active compounds, other fluids or materials,
combination or mixtures thereof and/or any other substance from one
or more internal/external fluid sources.
[0100] However, the use of a handpiece assembly with a distal
engagement member or shroud 2020, 2120 can be used in any other
skin treatment procedures besides those targeting hair growth. For
example, engagement member-equipped handpiece assemblies can be
used for basic skin abrasion procedures (e.g., dermabrasion, with
or without fluid delivery), acne, skin lightening, skin tightening,
anti-aging, oily skin, lip repair/plumping, damaged skin,
blackhead/sebum removal or extraction and/or the like.
Delivery of Hair Growth Treatment Agents with Other Steps or
Procedures
[0101] As noted herein, the delivery of hair growth agents to and
into a subject's skin can be facilitated and/or supplemented by one
or more additional steps or procedures. Such steps or procedures
can be performed or used before, during and/or after the delivery
of fluids and/or other treatment materials to the targeted skin
surface, as desired or required.
[0102] In some arrangements, for example, treatment fluids and/or
other materials (e.g., amino acids, antioxidants, Minoxidil, other
antihypertensive vasodilator agents, other hair growth-stimulating
agents, other natural or synthetic materials and/or the like) are
delivered to the targeted skin surface where hair growth is desired
prior to, during and/or after exfoliation of skin. In some
configurations, the fluids and/or other materials are delivered to
the skin via a handpiece assembly (e.g., with the assistance of
vacuum or suction to deliver one or more treatment fluids and/or
other materials toward the tip or distal end of the handpiece
assembly). The tip or distal end of the handpiece assembly can be
configured to selectively abrade or exfoliate skin. For example,
one or more abrading structures or features (e.g., spiral members,
posts, other protruding members, abrasive discs or abrasive
surfaces, diamonds, etc.) can be positioned along a tip or another
portion along a distal end of the handpiece assembly. In some
embodiments, as the handpiece assembly is moved relative to the
targeted skin tissue, such abrading structures or features can
selectively abrade or exfoliate skin tissue. As noted, the abrasion
or exfoliation can facilitate the delivery of treatment fluids
and/or other materials that are configured to promote hair growth
deeper into the skin tissue, thereby enhancing the treatment
procedure and increasing the likelihood that the treatment fluids
and/or other materials will help to accomplish hair growth and/or
other benefits related to hair health (e.g., strengthening hair,
improving follicle viability, etc.).
[0103] Additional details regarding devices, systems and methods of
skin abrasion and/or exfoliation are disclosed in U.S. patent
application Ser. No. 12/346,582, filed Dec. 30, 2008 and issued on
Jan. 1, 2013 as U.S. Pat. No. 8,343,116, U.S. patent application
Ser. No. 11/392,348, filed Mar. 29, 2006 and issued on Nov. 1, 2011
as U.S. Pat. No. 8,048,089, U.S. patent application Ser. No.
12/832,663, filed Jul. 8, 2010 and issued on Aug. 26, 2014 as U.S.
Pat. No. 8,814,836 and International Patent Application No.
PCT/US2014/024992, filed Mar. 12, 2014 and published on Sep. 25,
2014 as PCT Publ. No. WO 2014/151104, the entireties of which are
incorporated by reference herein.
[0104] The delivery of hair growth agents to a targeted skin
surface accompanied by abrasion or exfoliation can comprise a
multi-step (e.g., two-step process, three-step, more than
three-step, etc.) process. For example, in some embodiments, a
first step of the process comprises abrading and/or exfoliating
skin tissue. During and/or following such abrading and/or
exfoliation step, as noted above, one or more treatment fluids
and/or other materials (e.g., amino acids, antioxidants, Minoxidil,
other antihypertensive vasodilator agents, other hair
growth-stimulating agents, other natural or synthetic materials
and/or the like) can be advantageously delivered to the tissue.
Such fluids and/or other materials can be configured to help
promote skin growth.
[0105] According to some embodiments, as a follow-up step to
abrasion/exfoliation and delivery of treatment fluids/other
materials, one or more additional steps or procedures can be
selectively performed. For instance, one or more light treatments
can be performed on the targeted skin tissue to further help
promote hair growth. Such light treatments can include, but are not
necessarily limited to, the delivery of red (e.g., infrared) light,
ultraviolet light and/or light of different frequencies and/or of
different types, as desired or required. The delivery of light to
skin can be beneficial for hair growth in one or more different
ways. For example, light can be used to directly provide treatment
to skin tissue. Alternatively, light can be used to activate or
otherwise alter the function of a material that has been delivered
to the skin. Embodiments of light-emitted wands that can be used in
such procedures are discussed in greater detail below with
reference to FIGS. 10A and 10B.
[0106] In some embodiments, one or more forms of light can be
applied to the skin of the subject, before, during or after a hair
growth or other skin treatment procedure. The type of light, its
intensity, power, frequency, wavelength, duration of exposure
and/or other properties can vary, as desired or required for a
particular application or use. In some embodiments, one or more
properties of the light source can be varied, during a procedure
and/or between procedures. In some embodiments, as illustrated in
FIGS. 10A and 10B, the light comprises one or more LEDs or other
illumination sources. As with other modalities disclosed herein,
the light can be incorporated or attached to a handpiece that is
being used for microdermabrasion. However, in other embodiments,
the light source is separate and distinct from a microdermabrasion
handpiece assembly.
[0107] In some embodiments, two or more different types of light
sources can be provided as options for the subject or the user
performing a procedure on the subject. For example, with reference
back to FIGS. 10A and 10B, one of the light wands 402 is configured
to emit blue light (e.g., light having a wavelength of
approximately 475 nm), while another light wand 404 is configured
to emit red light (e.g., light having a wavelength of approximately
650 nm). In some embodiments, the application of light in the "red"
wavelength range (e.g., 780 nanometer (nm) to 622 nm) can be
helpful to hair stimulation and/or hair growth, either with or
without one or more other treatment steps (e.g., delivery of fluids
and/or other treatment materials to and/or within skin tissue,
vacuum or positive air pressure, pulsing, needling, massaging,
dermabrasion, other mechanical or other types of agitation,
heating/cooling, etc.). One or more wands or other light sources
can be provided having other target colors. Any other color or
light can be emitted, as desired or required. For example, a single
light wand can be selected that is adjustable so to select an exact
wavelength of light (in addition to or in lieu of selecting
intensity, power and/or any other properties).
[0108] One or more light sources can be incorporated directly or
indirectly into any handpiece assembly disclosed herein that is
configured to perform a hair growth treatment procedure. For
example, an annular light can be positioned along or near (or
embedded partially within) the lip at the distal tip of a handheld
assembly (e.g., identical or similar to the ones discussed herein
with reference to FIGS. 5 to 9). In other embodiments, the light
can be removably mounted along an outside surface of the
assembly.
[0109] In some embodiments, the use of light is configured to
chemically or biochemically "activate" one or more treatment fluids
and/or other substances have been or are being delivered to the
skin surface of the subject. The activation of certain substances
can provide one or more therapeutic or otherwise beneficial
results. In other embodiments, the use of red, blue and/or other
light can provide one or more direct benefits to the targeted skin
tissue. In some embodiments, for example, red or blue light therapy
can be used to complement the promotion of hair growth.
[0110] In some embodiments, light can be used to heat and/or at
least partially modify or affect (e.g., at the cellular level) skin
and adjacent tissue of the subject. For example, heat-producing or
heat-inducing light source can be directed at the skin for a
specific time period, before, during or after a skin treatment
procedure (e.g., hair growth procedure with or without
microdermabrasion or skin agitation). Light sources can include
bulbs (e.g., incandescent, fluorescent, low-pressure sodium,
high-intensity discharge, etc.), LEDs, lasers and/or the like. As
discussed in greater detail below, heating of the skin can provide
one or more benefits to the subject. For example, heating of skin
tissue can enable the pores of the subject to open or dilate (e.g.,
allowing serums and/or other treatment fluids or substances to
penetrate deeper into the skin surface). Heating of the skin can
also increase blood circulation in the adjacent vessels (e.g., to
help improve healing and recovery following a treatment
procedure).
[0111] Additional details regarding light treatment are provided in
International Patent Application No. PCT/US2014/024992, filed Mar.
12, 2014 and published on Sep. 25, 2014 as PCT Publ. No. WO
2014/151104, the entirety of which is incorporated by reference
herein.
[0112] According to some embodiments, light treatment comprises
treatment with light (e.g., using a light therapy handpiece or
other device or system) that is configured to emit light at a
wavelength of 610 to 650 nanometer (nm), e.g., in the "red" range.
In other embodiments, light treatment comprises treatment with
light that is configured to emit light at a wavelength of 800 to
1,050 nm, e.g., in the infrared range. In other embodiments, light
treatment comprises treatment with light that is configured to emit
light at a wavelength of 410 to 425 nm, e.g., in the "blue" range.
In some embodiments, the power of the light provided to skin tissue
can be 40 to 120 Joules/per cm.sup.2. (e.g., 40-50, 50-60, 60-70,
70-80, 80-90, 90-100, 100-110, 110-120 Joules/cm.sup.2, power
levels between the foregoing, levels below 40 Joules/cm.sup.2 or
levels above 120 Joules/cm.sup.2, as desired or required.
[0113] In any light treatment embodiments, light can be emitted
using any source or configuration, including, without limitation,
one or more LEDs. In some embodiments, emitted light (at one or
more frequencies, wavelengths, power levels, etc.) can be
selectively provided to skin to promote hair growth and/or hair
stimulation, either alone or in combination with one or more
treatment steps. The use of light can also assist skin in one or
more other ways, such as helping with acne, anti-aging, wrinkles
and/or the like.
[0114] One or more additional treatment steps and/or devices can be
incorporated into a particular treatment procedure, as desired or
required. For example, one or more of the following can be used to
further enhance the likelihood of hair growth resulting from a
particular treatment procedure, either in lieu of or in addition to
skin abrasion/exfoliation and/or light treatment: other energy
delivery (e.g., radiofrequency (RF) energy, microwave energy,
ultrasound energy, laser, iontophoresis, etc.), thermal
conditioning (e.g., cooling and/or heating of tissue before, during
and/or after one or more other steps of a procedure), mechanical
agitation, massaging and/or the like.
[0115] In some embodiments, in order to enhance a hair growth
procedure, heat transfer can be provided to the targeted scalp or
other skin surface. For example, as discussed above, the use of
selective light delivery can help provide heat to a targeted skin
surface. Heat transfer can comprise either heating or cooling,
depending on the desired therapeutic effect, protocol and/or the
like. Embodiments of separate handheld devices that are configured
to heat or cool a targeted skin surface are discussed below with
reference to FIGS. 11A and 11B.
[0116] In some arrangements, exposing the skin to hot and/or cold
temperature can assist with various aspects associated with hair
growth and/or other skin treatment techniques and procedures. For
example, as discussed herein, heating skin can open the skin's
pores, thereby allowing serums, other treatment fluids or materials
and/or the like to enhance penetration and migration of such
materials into the skin. Further, cooling the skin can cause pores
to close, at least partially, allowing therapeutic fluids and/or
other materials that previously entered the pores to stay within
the skin for a longer time period.
[0117] In some embodiments, one or more devices (e.g., handheld
devices) can be used to conductively cool and/or heat skin, before,
during and/or after a skin treatment procedure (e.g., hair growth
promotion procedure). One embodiment of such a heating and cooling
system is illustrated in FIGS. 11A and 11B. As shown, the system
can include a thermal docking station 510. In some embodiments, the
docking station 510 comprises one or more wells, ports or openings
514, 518 for receiving and thermally recharging thermal
conditioning handheld assemblies 600.
[0118] With continued reference to FIGS. 11A and 11B, the thermal
recharging station 510 can be in thermal communication with one or
more heating and/or cooling devices (not shown). In some
embodiments, one or more thermoelectric devices (e.g., Peltier
devices) are positioned along the outside, the inside and/or within
the walls of the station 510. However, any other type of heating
and/or cooling device can be used. In some embodiments, thermal
conditioning devices are positioned along the exterior surfaces of
the docking station walls (e.g., as schematically represented by
circles 530, 532 in FIG. 11A). Regardless of the quantity, type,
location, spacing, orientation and/or configuration of the thermal
conditioning devices, the devices can be adapted to conductively
heat or cool adjacent portions of the station 510, including the
wells 514, 518 that receive the thermal handpiece assemblies
600.
[0119] In some embodiments, the station comprises one or more
thermally conductive materials, such as, for example, aluminum,
copper, other metal or alloys. As illustrated in FIG. 11B, one or
more of the wells 514, 518 can include a pin, rod or other
protruding member 516, 520. As discussed in greater detail below,
the thermal conditioning handheld assemblies 600 can include a
central opening. In some embodiments, the assemblies 600 are
generally hollow along their centerlines. Accordingly, the
assemblies 600 can be conveniently mounted or otherwise positioned
on the pins 516, 520 when being placed within the wells 514, 518 of
the station 510. Therefore, as illustrated in FIG. 11A, the pins
516, 520 can securely maintain the thermal handheld assemblies in a
generally vertical orientation when the assemblies are positioned
within the station 510 for thermal recharging.
[0120] When the thermoelectric devices and/or other heating and/or
cooling devices of the station are activated, the wells of the
station can be heated or cooled, in accordance with the desired
thermal conditioning effect of that station 510. In some
embodiments, if thermoelectric devices are used to heat or cool the
station 510, an additional station (not shown) can be positioned on
the opposite surface of the thermoelectric device so that the
additional station also undergoes heating or cooling (e.g., the
opposite thermal effect of the main station).
[0121] The assembly 600 can comprise an inner core and an outer
housing or shell. In some embodiments, the inner core comprises
copper, aluminum and/or any other high heat transfer material
(e.g., beryllium, other metals or alloys, etc.). In some
embodiments, the copper and/or other material can be coated (e.g.,
plated) with one or more layers of nickel, chrome and/or the like.
The outer housing can include ABS, Nylon and/or any other plastic
or other material with a relatively low thermal conductivity (e.g.,
to avoid excessively or uncomfortably hot or cold temperatures
being felt by a user who grasps and handles the assembly 600).
[0122] According to some embodiments, the thermal handheld assembly
600 includes an interior lumen or opening that extends completely
or partially through the assembly. The proximal end of the assembly
600 can be placed in fluid communication with a vacuum conduit, if
the assembly will be configured for suction. In such arrangements,
the conduit is placed in fluid communication with a vacuum or
negative pressure source. In some embodiments, however, the heating
or cooling system is configured to be used without suction.
[0123] The handheld assembly 600 can comprise a distal head. In the
illustrated embodiment, the head includes a circular or rounded
outer shape, having a generally smooth surface. In some
embodiments, the head comprises one or more openings that are in
fluid communication with the internal lumen or passage of the
assembly 600. In some embodiments, the head forms a unitary
structure with and is part of the core of the assembly 600. As
such, it advantageously comprises one or more high heat transfer
materials (e.g., copper) that can be heated or cooled relatively
quickly when placed within a well of the station 510.
[0124] Regardless of their exact shape, size, configuration and/or
other properties, the thermal handheld assemblies 600 can be used
to selectively heat or cool a subject's skin surface. As noted
above, in one embodiment, the surface to be treated (e.g., scalp,
other skin surface where hair growth is desired, etc.) can first be
heated to open the skin pores and/or provide one or more other
benefits. With the pores open, a fluid delivery process can be
performed, either with or without skin abrasion. Accordingly, any
hair growth serums, other treatment fluids and/or other substances
that are delivered to the working end of a skin treatment device
(e.g., along the skin surface that was previously heated), could
pass deeper and/or with greater ease into the open pores of the
skin. Following the treatment protocol (e.g., fluid delivery only,
fluid delivery with dermabrasion, etc.), the user can use a cold
thermal conditioning assembly 600 to cool the skin surface that was
treated. As a result of cooling the skin surface, the pores of the
skin can at least partially close, thereby trapping the potentially
beneficial serums and/or other components within the skin. Such a
treatment method can provide for a quicker recovery time, fewer
complications and/or one or more other benefits or advantages.
[0125] According to some embodiments, the level of heating or
cooling of the thermal assemblies 600 can be adjusted and
controlled (e.g., by modifying the duty cycle of the thermoelectric
devices or any other heating or cooling device that is thermally
conditioning the station 510). In some embodiments, a thermostat
and/or other temperature detection is used to ensure that the
operating temperature of the station 510 and the handheld
assemblies that the station is configured to heat do not reach
dangerous or uncomfortable extremes.
[0126] In other embodiments, a skin surface can be heated or cooled
using any other method or device. For example, skin can be heated
using any of the energy or other modalities discussed herein (e.g.,
RF, ultrasound, microwave, etc.). In one embodiment, the liquids,
serums and/or other treatment fluids delivered to the tip of a
microdermabrasion device (e.g., from a vial or cartridge, a bottle
of a manifold or tower system, etc.) can be heated or cooled before
it reaches the skin surface. Therefore, one or more heating or
cooling devices can be incorporated into the microdermabrasion
handheld device or the fluid system that is coupled to the handheld
device.
Rollerball/Porous Assemblies for Fluid/Treatment Material
Delivery
[0127] In some embodiments, the various treatment devices, systems
and/or methods disclosed herein can be used together with
alternative handheld assemblies and/or other devices or systems to
help deliver hair growth fluids and/or other materials to a
targeted skin region (e.g., a subject's scalp surface). Examples of
such devices and systems are discussed below with reference to
FIGS. 12A-15.
[0128] One embodiment of an assembly 900 comprising a rollerball
and configured to be used for hair growth procedures is illustrated
in FIGS. 12A and 12B. The depicted assembly 900 includes a
handpiece and a tip that are integrated into a single unitary or
monolithic structure 910. In some embodiments, such a combined
handpiece and tip can be configured to be disposable so it is
replaced between uses. According to some embodiments, the assembly
900 comprises a cartridge or other fluid source 940 that is
configured to secure to the combination handpiece/tip 910.
[0129] With continued reference to FIG. 12B, the distal end 942 of
the cartridge 940 can include a rollerball 944 that is routed
through an interior portion of the combination handpiece/tip 910
when the cartridge 940 is positioned therein. In some embodiments,
the rollerball 944 extends to or near the distal end of the
combination handpiece/tip 910 when the assembly 900 is ready for
use. Accordingly, as the assembly 900 is moved relative to a
subject's skin surface (e.g. scalp), the rollerball can at least
partially contact the skin surface being treated and rotate.
Rotation of the rollerball 944 can facilitate the transfer of fluid
and/or other contents of the cartridge 940 to the distal end of the
combination handpiece/tip 910, and thus, the skin surface.
[0130] As shown in FIGS. 12A and 12B, the proximal end 945 of the
cartridge 940 can include a closure member 946 that sealingly
encloses an interior of the cartridge 940. Thus, in some
embodiments, the interior of the cartridge 940 can be opened,
refilled and closed. However, in other arrangements, the cartridge
940 is configured to remain sealed at all times. Thus, is such
configurations, the cartridges are disposable after use. The above
disclosure regarding cartridges that can be opened and cartridges
that are configured to remain sealed can be applied to any of the
assembly arrangements disclosed herein or variations thereof.
[0131] In some embodiments, the cartridge 940 included in the
assembly 900 of FIGS. 12A and 12B can be re-used between sequential
treatment procedures (e.g., hair growth treatments). For example,
once the subject has completed a particular treatment session, the
subject can be permitted to take home any used cartridge or
cartridges (to the extent two or more different serums or other
treatment materials were used). Thus, the subject can bring the
unused cartridges to a subsequent treatment session, thereby
eliminating waste and reducing the overall expense of a procedure.
In some embodiments, the subject can be instructed to apply one or
more of the serums and/or other materials contained within the
corresponding unused cartridges 940 to his or her scalp or other
skin between office visits. Accordingly, in order to prevent
contamination of the cartridges and their internal contents, to
prevent evaporation, leaks or other loss of the internal contents
of the cartridges, to otherwise protect the cartridges (e.g., the
rollerball 944 located along the cartridge's distal end) and/or to
provide one or more additional benefits or advantages, a cap 950
can be used to protect the distal end 942 of a cartridge between
uses. The rollerball 944 can facilitate the application of fluid to
the subject's scalp or other skin surface where hair growth is
desired between office visits. For example, the use of a rollerball
can advantageously permit fluid to be delivered from the interior
of the cartridge 940 to the subject's skin surface without the use
of suction or a handpiece. Thus, the overall effectiveness of a
hair growth and/or other skin treatment procedure can be
advantageously enhanced by such embodiments.
[0132] In some embodiments, for example, two or more main hair
growth serums or materials can be used during a treatment
procedure. Thus, during a first visit to a professional, the
subject undergoes a two-step treatment procedure in which a first
formulation is first applied to the subject's skin surface (e.g.,
with or without the application of vacuum). As a follow-up step, a
second serum or other fluid or material is applied to the skin. In
some embodiments, as discussed herein, the user is then provided
with cartridges or other fluid containers. Such cartridges can be
advantageously returned to the professional for conducting a
follow-up procedure during a subsequent visit. In addition, the
subject can be instructed, in accordance with certain protocols, to
periodically apply one or more of these serums or fluids to his or
her skin between visits, as desired or required.
[0133] As noted herein, the combination handpiece/tip 910 included
in the assembly of FIGS. 12A and 12B can be disposable between uses
or sequential procedures. Thus, the use of such a disposable
portion can reduce the likelihood of the transfer of contamination
between subjects and/or procedures, thereby improving the overall
hygiene and safety of skin treatment procedures.
[0134] With continued reference to FIGS. 12A and 12B, the
combination handpiece/tip 910 can include a suction port or conduit
918 that is configured to be placed in fluid communication with a
vacuum source. In the illustrated embodiment, suction port 918
extends along an exterior of the handpiece/tip component 910 (e.g.,
at an angle); however, in other arrangements, the suction port or
conduit 918 can extend, at least partially or completely, within an
interior of the assembly 900, as desired or required. In yet other
embodiments, the assembly 900 is not configured to be placed in
fluid communication with a suction or vacuum source. Accordingly,
in such arrangements, the assembly need not have any suction or
vacuum ports, passages, conduits and/or other related components or
features.
[0135] In any of the embodiments disclosed herein, a rollerball or
similar feature along the distal end of a cartridge, handpiece
and/or tip can be replaced with one or more other features that to
help to selectively deliver fluid to the skin surface being treated
(e.g., from a reservoir of a cartridge or other container placed in
fluid communication with the system). For example, as illustrated
in the embodiment of FIG. 13, the rollerball can be replaced with a
wicking or other fluidly porous member 1044 along its distal
end.
[0136] With reference to FIG. 13, the distal end 1042 of the
cartridge 1040 can include a wicking member 1044. In some
embodiments, the rollerball 944 extends to or near the distal end
of the combination handpiece/tip when the assembly is ready for
use. Accordingly, as the assembly is moved relative to a subject's
skin surface (e.g., scalp, other skin region where hair growth is
desired, etc.), the wicking member 1044 can at least partially
contact the skin surface being treated and deliver fluid from the
fluid reservoir of the cartridge or other container 1040 to the
skin surface. The wicking member 1044 can comprise one or more
porous materials or features, such as, for example, foam, a porous
stone, sponge or other member, another material or member
comprising a porous or otherwise open or semi-open structure. In
some embodiments, the wicking or other porous member 1044 can be
saturated with the particular fluids contained within the reservoir
of the cartridge or other container member. Thus, the wicking
member 1044 can retain the necessary moisture level to selectively
deliver fluid to the skin surface treated, even when the level of
fluid within the cartridge or the other container 1040 is
relatively low.
[0137] With continued reference to FIG. 13, the wicking member 1044
can comprise one or more foams, thermoplastics and/or other
materials. The cross-sectional size of the wicking member can be
between 1/4 inch and 2 inches. In some embodiments, the wicking
member 1044 extends, at least partially, within the interior
reservoir of the cartridge or other container. The wicking member
1044 can include any cross-sectional shape, as desired or required,
such as, for example, circular, oval, square or other rectangular,
other polygonal (e.g., triangular, pentagonal, hexagonal,
octagonal, decagonal, etc.), irregular.
[0138] FIG. 14 schematically illustrates a skin treatment system
1000 similar to the system depicted in FIG. 13. As shown, the
system 1000 can include a cartridge or other container 1040
comprising a wicking or other porous structure 1044 along its
distal end. The wicking or other porous structure can include one
or more materials that are configured to at least partially absorb,
adsorb and/or otherwise retain a volume of liquid or other
material. As discussed herein, according to some embodiments, such
a wicking structure 1044 can be used to keep the distal end of the
cartridge 1040 at least partially moist for purposes of delivering
fluids and/or other materials to the subject's scalp and/or other
skin surface during a particular procedure (e.g., a hair growth
procedure).
[0139] According to some embodiments, the wicking or other porous
structure 1044 incorporated into any of the embodiments herein
(e.g., the distal end of a cartridge or other container, the
handpiece, the tip, etc.) can be used for one or more purposes. For
example, in some embodiments, the wicking material can be used to
perform one or more of the following functions: (i) to store one or
more materials within a portion of a skin treatment assembly (e.g.,
along a distal end of a cartridge, along a tip of an assembly,
along a handpiece, etc.); (ii) as a filter (e.g., for waste debris
leaving the skin surface being treated); (iii) for delivering
fluids and/or other materials to the skin surface being treated;
and/or the like. For example, in one embodiment, a wicking or other
porous material 1044 can include a treatment material (e.g., as a
liquid, gel, powder, etc.). Water or another dilution agent can
then be delivered to or near the wicking or porous member 1040 to
selectively release the materials stored within the wicking or
other porous member.
[0140] According to some embodiments, as schematically illustrated
in FIG. 15, a rollerball or other movable member 1146 can be
positioned along the distal end of a wicking or other porous member
or structure 1144. In such a system 1100, the wicking member 1144
and rollerball 1146 can be positioned along the distal end of a
cartridge 1140. Alternatively, as with other configurations
disclosed herein, the wicking member 1144 and/or the rollerball
1146 (or combination thereof) can be located along the handpiece,
the tip and/or any other location of the skin treatment assembly.
In such embodiments, the rollerball 1146 can be kept in fluid
communication with the fluid contained within the cartridge or
other container with the assistance of the wicking member or
structure. In other words, the proximal end of the rollerball can
be advantageously maintained moist with the assistance of the
wicking material.
[0141] Additional details regarding the use of rollerballs, wicking
members and/or other porous structures to deliver treatment fluids
and/or other materials to the scalp or other targeted skin surface
of a subject are provided in International Patent Application No.
PCT/US2015/067531, filed Dec. 22, 2015 and published on Jun. 30,
2016 as PCT Publ. No. WO 2016/067531, the entirety of which is
incorporated by reference herein.
Implants/Transplants
[0142] In some embodiments, the various treatment devices, systems
and/or methods disclosed herein can be used together with hair
implants to further enhance a hair growth or hair supplementation
procedure. For example, the delivery of certain fluids and/or other
materials to a targeted skin surface, the use of exfoliation or
abrasion steps, the delivery of light (e.g., infrared, ultraviolet,
etc.), the use of laser, the use of other energy modalities and/or
the like can be used to supplement a hair implant or hair
transplant procedure. The use of the various technologies described
herein (or referenced herein), or variations thereof, can further
improve the likelihood of success for a hair implant or hair
transplant procedure. By way of example, the selective delivery of
growth factors (e.g., especially in light of the ability to drive
or push such growth factors deeper into a portion of targeted
tissue) can bolster the health and viability of adjacent or
surrounding hair implants.
Massaging/Other Tip Details
[0143] In some embodiments, the targeted skin surface (e.g., scalp,
other skin area where hair growth is desired, etc.) can be massaged
or otherwise manipulated in conjunction with a hair growth
procedure or protocol. For example, in some arrangements, the scalp
or other targeted skin surface is massaged prior to and/or during
the delivery of one or more fluids, agents and/or other materials.
The messaging and/or other agitation of the scalp or other targeted
skin tissue of the subject can be accomplished manually and/or
using a device or system. For example, in some embodiments,
massaging of skin tissue can be accomplished using a handpiece
assembly (e.g., similar to any of the assemblies disclosed herein,
such as, for example, those illustrated in FIGS. 1 to 15). In some
embodiments, a massaging tip (e.g., a tip that is removably or
permanently attached to the distal end or tip of the handpiece
assembly) can be used to create the desired or required massaging
or agitation action. For instance, the tip can include one or more
undulations or other features (e.g., recesses, protrusions, etc.)
that, when moved against the adjacent skin tissue, can massage such
skin tissue. Such massaging action can be accomplished together
with or in lieu of abrasion, as desired or required. In some
embodiments, massaging of skin tissue can provide one or more
therapeutic benefits related to hair growth. The massaging can help
stimulate certain anatomical reactions that may assist with hair
growth. In some arrangements, massaging can help drive or move any
treatment fluids or other materials deeper into the scalp or other
targeted tissue.
[0144] In other embodiments, tips or other distal portions of a
handpiece assembly used in hair growth procedures can have include
one or more desired materials on or within their structure. As
discussed in greater detail herein, one or more materials can be
strategically embedded, impregnated, placed, stored and/or
otherwise disposed on one or more surfaces or areas of the tip or
other portion or component of the skin treatment system. Such
materials can comprise solids, semi-solids, other dried substances,
gels, concentrated solutions and/or the like. For example, such
materials can be provided in loose form (e.g., positioned on or
within a recess, other portion of the tip, within a cartridge or
other container, adhered to one or more surfaces, etc.), as a
tablet, capsule, pill, disc or other dissolvable solid, saturated
within a foam pad or other sponge-like material and/or the like.
Thus, in certain arrangements, water (e.g., distilled, tap water,
filtered, etc.), saline, other dilutants and/or other fluids which
are delivered to the tip can selectively dissolve, liquefy, melt,
soften, dilute or otherwise prepare the materials embedded,
impregnated and/or otherwise positioned on the tip, within a
cartridge or other container and/or on or within another portion or
component of a skin treatment system (e.g., handpiece assembly,
fluid line upstream of the handpiece assembly, etc.). Accordingly,
any desired hair growth materials or formulations can be
advantageously provided to the skin surface being treated, as
desired or required. Such materials can include, without
limitation, one or more of the following: growth factors (e.g.,
human-derived, non-human derived, liposome (courier) chemically
altered growth factors, etc.), amino acids (e.g., leucine,
isoleucine, valine, etc.), antioxidants, minoxidil, other
antihypertensive vasodilators, finasteride, dutasteride,
ketoconazole, spironolactone, flutamide, catechin, epicatechin,
other phytochemicals, carnitine, rejuvaplex, copper peptides, other
hair growth-stimulating agents, other pharmaceuticals and
non-pharmaceuticals, plant-derived products, cleansing or
pre-cleansing shampoos, other cleansing or pre-cleansing solutions
(e.g., salicylic acid, GlySal.TM. (glycolic acid and salicylic acid
mix), other acids, etc.), and other natural and synthetic
materials.
[0145] According to some embodiments, one or more treatment
materials can be applied to the targeted skin tissue (e.g., scalp)
using dabbing the skin tissue (e.g., manually) with one or more
treatment materials. Such dabbing action can be accomplished by
contacting and/or moving a tip or other discharge portion of a
fluid container (e.g., bottle, vial, etc.) relative to the targeted
tissue. In other embodiments, an applicator (e.g., swab, fabric,
other porous or absorbent member, etc.) can be used to deliver the
fluid to the skin tissue, as desired or required. Any other device
or method can also be used to deliver fluid and/or other treatment
material to the skin surface, including, without limitation,
spraying, misting, brush, roller, other dispenser and/or the
like.
Needling
[0146] In some embodiments, needles may be used to help the passage
of one or more treatment fluids and/or other materials deeper into
skin tissue. For example, the use of needles can create passages
within the targeted skin tissue to permit growth factors and/or
other fluids or materials to be delivered deeper into the skin.
Relatedly, such configurations can also assist in promoting the
passage of treatment fluids and/or other materials closer to any
hair follicles (e.g. including any follicles that result from a
hair implant or transplant procedure). The use of needling or
similar procedure that assists with the passage of fluids and/or
other materials through the skin can be used alone or in
conjunction with one or more techniques (e.g., abrasion,
exfoliation, energy delivery, laser, light treatment, pulsing,
other mechanical agitation, thermal treatment, etc.), as desired or
required. For example, needling can include the use of a
reciprocating needling assembly identical or similar to the one
discussed herein with reference to FIGS. 4A-4E. Additional details
regarding needling are provided in International Patent Application
No. PCT/US2014/024992, filed Mar. 12, 2014 and published on Sep.
25, 2014 as PCT Publ. No. WO 2014/151104, the entirety of which is
incorporated by reference herein.
[0147] With respect to needling embodiments, a needling step can be
used in advance of and/or after the delivery of growth factors
and/or other fluids or materials that are configured to promote
hair growth or stability. In some embodiments, the needles or other
members that are used to at least partially penetrate skin can be
coated and/or otherwise configured to comprise one or more
treatment fluids and/or other materials (e.g., growth factors).
Such coated needles can be solid or hollow, as desired or required
for a particular application or use. For example, such factors
and/or other materials can be disposed along one or more surfaces
(e.g., exposed surfaces) of the needles. In other embodiments, the
various treatment materials can be located along interior cavities
(e.g., interior of the needles, other recesses along or near the
needles, and/or the like) of the corresponding handpiece assembly
or other device or system. In some embodiments, such materials can
be provided on or near the needles in a solid, semi-sold, gel,
granular and/or other non-liquid form. In such configuration, the
various materials positioned on, along and/or near the needles or
similar members can be configured to at least partially dissolve
for release onto a targeted skin surface. The use of the
embodiments can further enhance the delivery of growth factors
and/or other materials deeper into skin tissue to help promote hair
growth and/or hair strengthening.
[0148] In other embodiments, needles are at least partially hollow
to permit the delivery of fluids and/or other treatment materials
(e.g., growth factors) therethrough. The use of such configurations
can assist with the efficient and selective delivery of precise
amounts of growth factors and/or other materials to and into the
targeted skin tissue surface. For example, in some arrangements,
the hollow portions of the needles are in fluid communication with
a reservoir to allow the user to delivery one or more fluids and/or
other materials at a desired flowrate, in accordance with a
particular application, protocol or treatment procedure.
[0149] In any needle embodiments discussed herein, or alternatives
thereof, needles that are used as part of a treatment procedure can
be coated with one or more treatment materials. As noted above,
treatment materials can include, without limitation, one or more of
the following: growth factors (e.g., human-derived, non-human
derived, liposome (courier) chemically altered growth factors,
etc.), amino acids (e.g., leucine, isoleucine, valine, etc.),
antioxidants, minoxidil, other antihypertensive vasodilators,
finasteride, dutasteride, ketoconazole, spironolactone, flutamide,
catechin, epicatechin, other phytochemicals, carnitine, rejuvaplex,
copper peptides, other hair growth-stimulating agents, other
pharmaceuticals and non-pharmaceuticals, plant-derived products,
cleansing or pre-cleansing shampoos, other cleansing or
pre-cleansing solutions (e.g., salicylic acid, GlySal.TM. (glycolic
acid and salicylic acid mix), other acids, etc.), other natural and
synthetic materials and/or the like. Such treatment materials can
be coated onto the needles (e.g., completely or at least
partially), otherwise deposited on the needles and/or the like. In
some embodiments, such materials can be provided as a gel, solid,
semi-solid and/or another form that can be dissolved or otherwise
released in the presence of water, saline and/or another
liquid.
Massaging/Undulating Embodiments for Enhanced Infusion
[0150] In some embodiments, a tip or other distal portion of a
treatment device or system (e.g., handpiece assembly or something
to secure to or near the distal end of a handpiece assembly) is
configured to massage or otherwise manipulate the skin tissue being
contacted without necessarily abrading skin tissue. For example, in
some embodiments, the tip or other distal portion of a handpiece
assembly can include non-linear or undulating portion(s) and/or
feature(s) that are configured to provide mechanical agitation
(e.g., with or without abrasion or exfoliation) when the handpiece
assembly or other device or system is moved relative to said skin
surface. In some embodiments, such massaging or pressure-inducing
feature(s) and/or other configuration(s) can help open pores and/or
otherwise facilities the penetration of treatment materials that
are delivered to the skin deeper into the skin. This can enhance a
treatment procedure, as the treatment materials can be "driven" or
moved deeper into the skin tissue (e.g., closer to the follicle
roots, closer to deeper portions of skin tissue, etc.) to further
promote hair growth/stimulation, scape or skin health and/or the
like.
Scalp Health/Other Indications
[0151] In some embodiments, the same or similar procedures
described herein, or equivalents thereof, can be used to treat
other ailments or conditions related to skin or hair. For example,
in some embodiments, the procedures can be used to improve the
health of a subject's scalp or other skin surface, to help treat or
otherwise improve a subject's conditions related to dandruff,
psoriasis, seborrheic dermatitis and/or the like.
[0152] To assist in the description of the disclosed embodiments,
words such as upward, upper, bottom, downward, lower, rear, front,
vertical, horizontal, upstream, downstream have been used above to
describe different embodiments and/or the accompanying figures. It
will be appreciated, however, that the different embodiments,
whether illustrated or not, can be located and oriented in a
variety of desired positions.
[0153] Although several embodiments and examples are disclosed
herein, the present application extends beyond the specifically
disclosed embodiments to other alternative embodiments and/or uses
of the inventions and modifications and equivalents thereof. It is
also contemplated that various combinations or subcombinations of
the specific features and aspects of the embodiments may be made
and still fall within the scope of the inventions. Accordingly, it
should be understood that various features and aspects of the
disclosed embodiments can be combine with or substituted for one
another in order to form varying modes of the disclosed inventions.
Thus, it is intended that the scope of the present inventions
herein disclosed should not be limited by the particular disclosed
embodiments described above, but should be determined only by a
fair reading of the claims that follow.
[0154] While the inventions are susceptible to various
modifications, and alternative forms, specific examples thereof
have been shown in the drawings and are herein described in detail.
It should be understood, however, that the inventions are not to be
limited to the particular forms or methods disclosed, but, to the
contrary, the inventions are to cover all modifications,
equivalents, and alternatives falling within the spirit and scope
of the various embodiments described and the appended claims. Any
methods disclosed herein need not be performed in the order
recited. The methods summarized above and set forth in further
detail below describe certain actions taken by a practitioner;
however, it should be understood that they can also include the
instruction of those actions by another party. The methods
summarized above and set forth in further detail below describe
certain actions taken by a user (e.g., a professional in some
instances); however, it should be understood that they can also
include the instruction of those actions by another party. Thus,
actions such as "moving a handpiece" or "delivering a fluid"
include "instructing moving a handpiece" and "instructing
delivering a fluid." The ranges disclosed herein also encompass any
and all overlap, sub-ranges, and combinations thereof. Language
such as "up to," "at least," "greater than," "less than,"
"between," and the like includes the number recited. Numbers
proceeded by a term such as "about" or "approximately" include the
recited numbers. For example, "about 10 mm" includes "10 mm." Terms
or phrases preceded by a term such as "substantially" include the
recited term or phrase. For example, "substantially parallel"
includes "parallel."
* * * * *