U.S. patent application number 17/505561 was filed with the patent office on 2022-04-21 for mutant chitinase with enhanced expression and activity. This patent application is currently assigned to The Regents of the University of California. The applicant listed for this patent is The Regents of the University of California, Washington University. Invention is credited to Benjamin Barad, James Fraser, Richard Locksley, Steven Van Dyken.
Application Number | 20220119790 17/505561 |
Document ID | / |
Family ID | |
Filed Date | 2022-04-21 |
United States Patent Application | 20220119790 |
Kind Code | A1 |
Barad; Benjamin ; et al. | April 21, 2022 |
Provided are engineered novel forms of the acidic mammalian chitinase having enhanced expression and having improved catalytic activity. The novel forms of the mammalian acidic chitinase comprise one or more amino acid substitutions, relative to the native sequence, that impart these improved properties. The novel proteins may be used therapeutically for the prevention and treatment of airway conditions associated with environmental chitin exposure and accumulation.
Inventors: | Barad; Benjamin; (San Diego, CA) ; Fraser; James; (San Francisco, CA) ; Van Dyken; Steven; (Saint Louis, MO) ; Locksley; Richard; (San Francisco, CA) | ||||||||||
Applicant: |
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Assignee: | The Regents of the University of
California Oakland CA Washtington University Saint Louis MO |
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Appl. No.: | 17/505561 | ||||||||||
Filed: | October 19, 2021 |
Application Number | Filing Date | Patent Number | ||
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63093777 | Oct 19, 2020 | |||
International Class: | C12N 9/42 20060101 C12N009/42 |
Sequence CWU 1
1
241476PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptide 1Met Thr Lys Leu Ile Leu Leu Thr Gly Leu Val
Leu Ile Leu Asn Leu1 5 10 15Gln Leu Gly Ser Ala Tyr Gln Leu Thr Cys
Tyr Phe Thr Asn Trp Ala 20 25 30Gln Tyr Arg Pro Gly Leu Gly Arg Phe
Met Pro Asp Asn Ile Asp Pro 35 40 45Cys Leu Cys Thr His Leu Ile Tyr
Ala Phe Ala Gly Arg Gln Asn Asn 50 55 60Glu Ile Thr Thr Ile Glu Trp
Asn Asp Val Thr Leu Tyr Gln Ala Phe65 70 75 80Asn Gly Leu Lys Asn
Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile 85 90 95Gly Gly Trp Asn
Phe Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr 100 105 110Pro Glu
Asn Arg Gln Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg 115 120
125Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser
130 135 140Arg Gly Ser Pro Pro Gln Asp Lys His Leu Phe Thr Val Leu
Val Gln145 150 155 160Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys
Gln Ile Asn Lys Pro 165 170 175Arg Leu Met Val Thr Ala Ala Val Ala
Ala Gly Ile Ser Asn Ile Gln 180 185 190Ser Gly Tyr Glu Ile Pro Gln
Leu Ser Gln Tyr Leu Asp Tyr Ile His 195 200 205Val Met Thr Tyr Asp
Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu 210 215 220Asn Ser Pro
Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Thr Tyr225 230 235
240Leu Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro
245 250 255Ala Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn
Phe Ile 260 265 270Leu Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro
Thr Ser Gly Ala 275 280 285Gly Pro Ala Gly Pro Tyr Ala Lys Glu Ser
Gly Ile Trp Ala Tyr Tyr 290 295 300Glu Ile Cys Thr Phe Leu Lys Asn
Gly Ala Thr Gln Gly Trp Asp Ala305 310 315 320Pro Gln Glu Val Pro
Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr 325 330 335Asp Asn Ile
Lys Ser Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn 340 345 350Lys
Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr 355 360
365Gly Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys
370 375 380Lys Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala
Gln Pro385 390 395 400Ile Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser
Gly Asn Gly Ser Gly 405 410 415Ser Ser Ser Ser Gly Gly Ser Ser Gly
Gly Ser Gly Phe Cys Ala Val 420 425 430Arg Ala Asn Gly Leu Tyr Pro
Val Ala Asn Asn Arg Asn Ala Phe Trp 435 440 445His Cys Val Asn Gly
Val Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu 450 455 460Val Phe Asp
Thr Ser Cys Asp Cys Cys Asn Trp Ala465 470 4752476PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
2Met Thr Lys Leu Ile Leu Leu Thr Gly Leu Val Leu Ile Leu Asn Leu1 5
10 15Gln Leu Gly Ser Ala Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp
Ala 20 25 30Gln Tyr Arg Pro Gly Leu Gly Arg Phe Met Pro Asp Asn Ile
Asp Pro 35 40 45Cys Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Arg
Gln Asn Asn 50 55 60Glu Ile Thr Thr Ile Glu Trp Asn Asp Val Thr Leu
Tyr Gln Ala Phe65 70 75 80Asn Gly Leu Lys Asn Lys Asn Ser Gln Leu
Lys Thr Leu Leu Ala Ile 85 90 95Gly Gly Trp Asn Phe Gly Thr Ala Pro
Phe Thr Ala Met Val Ser Thr 100 105 110Pro Glu Asn Arg Gln Thr Phe
Ile Thr Ser Val Ile Lys Phe Leu Arg 115 120 125Gln Tyr Glu Phe Asp
Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser 130 135 140Arg Gly Ser
Pro Pro Gln Asp Lys His Leu Phe Thr Val Leu Val Gln145 150 155
160Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro
165 170 175Arg Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn
Ile Gln 180 185 190Ser Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu
Asp Tyr Ile His 195 200 205Val Met Thr Tyr Asp Leu His Gly Ser Trp
Glu Gly Tyr Thr Gly Glu 210 215 220Asn Ser Pro Leu Tyr Lys Tyr Pro
Thr Asp Thr Gly Ser Asn Ala Tyr225 230 235 240Leu Asn Val Asp Tyr
Ala Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro 245 250 255Ala Glu Lys
Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile 260 265 270Leu
Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala 275 280
285Gly Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr
290 295 300Glu Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln Gly Trp
Asp Ala305 310 315 320Pro Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn
Val Trp Val Gly Tyr 325 330 335Asp Asn Ile Lys Ser Phe Asp Ile Lys
Ala Gln Trp Leu Lys His Asn 340 345 350Lys Phe Gly Gly Ala Met Val
Trp Ala Ile Asp Leu Asp Asp Phe Thr 355 360 365Gly Thr Phe Cys Asn
Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys 370 375 380Lys Ala Leu
Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro385 390 395
400Ile Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly
405 410 415Ser Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe Cys
Ala Val 420 425 430Arg Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg
Asn Ala Phe Trp 435 440 445His Cys Val Asn Gly Val Thr Tyr Gln Gln
Asn Cys Gln Ala Gly Leu 450 455 460Val Phe Asp Thr Ser Cys Asp Cys
Cys Asn Trp Ala465 470 4753476PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptide 3Met Thr Lys Leu Ile Leu
Leu Thr Gly Leu Val Leu Ile Leu Asn Leu1 5 10 15Gln Leu Gly Ser Ala
Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala 20 25 30Gln Tyr Arg Pro
Gly Leu Gly Arg Phe Met Pro Asp Asn Ile Asp Pro 35 40 45Cys Leu Cys
Thr His Leu Ile Tyr Ala Phe Ala Gly Arg Gln Asn Asn 50 55 60Glu Ile
Thr Thr Ile Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe65 70 75
80Asn Gly Leu Lys Asn Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile
85 90 95Gly Gly Trp Asn Phe Gly Thr Ala Pro Phe Thr Ala Met Val Ser
Thr 100 105 110Pro Glu Asn Arg Gln Thr Phe Ile Thr Ser Val Ile Lys
Phe Leu Arg 115 120 125Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp
Glu Tyr Pro Gly Ser 130 135 140Arg Gly Ser Pro Pro Gln Asp Lys His
Leu Phe Thr Val Leu Val Gln145 150 155 160Glu Met Arg Glu Ala Phe
Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro 165 170 175Arg Leu Met Val
Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln 180 185 190Ser Gly
Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His 195 200
205Val Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu
210 215 220Asn Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn
Thr Tyr225 230 235 240Leu Asn Val Asp Tyr Ala Met Asn Tyr Trp Lys
Asp Asn Gly Ala Pro 245 250 255Ala Glu Lys Leu Ile Val Gly Phe Pro
Thr Tyr Gly His Asn Phe Ile 260 265 270Leu Ser Asn Pro Ser Asn Thr
Gly Ile Gly Ala Pro Thr Ser Gly Ala 275 280 285Gly Pro Ala Gly Pro
Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr 290 295 300Glu Ile Cys
Thr Phe Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala305 310 315
320Pro Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr
325 330 335Asp Asn Ile Lys Ser Phe Asp Ile Lys Ala Gln Trp Leu Lys
His Asn 340 345 350Lys Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu
Asp Asp Phe Thr 355 360 365Gly Thr Phe Cys Asn Gln Gly Lys Phe Pro
Leu Ile Ser Thr Leu Lys 370 375 380Lys Ala Leu Gly Leu Gln Ser Ala
Ser Cys Thr Ala Pro Ala Gln Pro385 390 395 400Ile Glu Pro Ile Thr
Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly 405 410 415Ser Ser Ser
Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe Cys Ala Val 420 425 430Arg
Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg Asn Ala Phe Trp 435 440
445His Cys Val Asn Gly Val Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu
450 455 460Val Phe Asp Thr Ser Cys Asp Cys Cys Asn Trp Ala465 470
4754476PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptide 4Met Thr Lys Leu Ile Leu Leu Thr Gly Leu Val
Leu Ile Leu Asn Leu1 5 10 15Gln Leu Gly Ser Ala Tyr Gln Leu Thr Cys
Tyr Phe Thr Asn Trp Ala 20 25 30Gln Tyr Arg Pro Gly Leu Gly Arg Phe
Met Pro Asp Asp Ile Asp Pro 35 40 45Cys Leu Cys Thr His Leu Ile Tyr
Ala Phe Ala Gly Arg Gln Asn Asn 50 55 60Glu Ile Thr Thr Ile Glu Trp
Asn Asp Val Thr Leu Tyr Gln Ala Phe65 70 75 80Asn Gly Leu Lys Asn
Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile 85 90 95Gly Gly Trp Asn
Phe Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr 100 105 110Pro Glu
Asn Arg Gln Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg 115 120
125Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser
130 135 140Arg Gly Ser Pro Pro Gln Asp Lys His Leu Phe Thr Val Leu
Val Gln145 150 155 160Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys
Gln Ile Asn Lys Pro 165 170 175Arg Leu Met Val Thr Ala Ala Val Ala
Ala Gly Ile Ser Asn Ile Gln 180 185 190Ser Gly Tyr Glu Ile Pro Gln
Leu Ser Gln Tyr Leu Asp Tyr Ile His 195 200 205Val Met Thr Tyr Asp
Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu 210 215 220Asn Ser Pro
Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Thr Tyr225 230 235
240Leu Asn Val Asp Tyr Ala Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro
245 250 255Ala Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn
Phe Ile 260 265 270Leu Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro
Thr Ser Gly Ala 275 280 285Gly Pro Ala Gly Pro Tyr Ala Lys Glu Ser
Gly Ile Trp Ala Tyr Tyr 290 295 300Glu Ile Cys Thr Phe Leu Lys Asn
Gly Ala Thr Gln Gly Trp Asp Ala305 310 315 320Pro Gln Glu Val Pro
Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr 325 330 335Asp Asn Ile
Lys Ser Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn 340 345 350Lys
Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr 355 360
365Gly Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys
370 375 380Lys Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala
Gln Pro385 390 395 400Ile Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser
Gly Asn Gly Ser Gly 405 410 415Ser Ser Ser Ser Gly Gly Ser Ser Gly
Gly Ser Gly Phe Cys Ala Val 420 425 430Arg Ala Asn Gly Leu Tyr Pro
Val Ala Asn Asn Arg Asn Ala Phe Trp 435 440 445His Cys Val Asn Gly
Val Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu 450 455 460Val Phe Asp
Thr Ser Cys Asp Cys Cys Asn Trp Ala465 470 4755476PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
5Met Thr Lys Leu Ile Leu Leu Thr Gly Leu Val Leu Ile Leu Asn Leu1 5
10 15Gln Leu Gly Ser Ala Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp
Ala 20 25 30Gln Tyr Arg Pro Gly Leu Gly Arg Phe Met Pro Asp Asp Ile
Asn Pro 35 40 45Cys Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Arg
Gln Asn Asn 50 55 60Glu Ile Thr Thr Ile Glu Trp Asn Asp Val Thr Leu
Tyr Gln Ala Phe65 70 75 80Asn Gly Leu Lys Asn Lys Asn Ser Gln Leu
Lys Thr Leu Leu Ala Ile 85 90 95Gly Gly Trp Asn Phe Gly Thr Ala Pro
Phe Thr Ala Met Val Ser Thr 100 105 110Pro Glu Asn Arg Gln Thr Phe
Ile Thr Ser Val Ile Lys Phe Leu Arg 115 120 125Gln Tyr Glu Phe Asp
Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser 130 135 140Arg Gly Ser
Pro Pro Gln Asp Lys His Leu Phe Thr Val Leu Val Gln145 150 155
160Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro
165 170 175Arg Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn
Ile Gln 180 185 190Ser Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu
Asp Tyr Ile His 195 200 205Val Met Thr Tyr Asp Leu His Gly Ser Trp
Glu Gly Tyr Thr Gly Glu 210 215 220Asn Ser Pro Leu Tyr Lys Tyr Pro
Thr Asp Thr Gly Ser Asn Thr Tyr225 230 235 240Leu Asn Val Asp Tyr
Ala Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro 245 250 255Ala Glu Lys
Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile 260 265 270Leu
Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala 275 280
285Gly Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr
290 295 300Glu Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln Gly Trp
Asp Ala305 310 315 320Pro Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn
Val Trp Val Gly Tyr 325 330 335Asp Asn Ile Lys Ser Phe Asp Ile Lys
Ala Gln Trp Leu Lys His Asn 340 345 350Lys Phe Gly Gly Ala Met Val
Trp Ala Ile Asp Leu Asp Asp Phe Thr 355 360 365Gly Thr Phe Cys Asn
Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys 370 375 380Lys Ala Leu
Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro385 390 395
400Ile Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly
405 410 415Ser Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe Cys
Ala Val 420 425 430Arg Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg
Asn Ala Phe Trp 435 440 445His Cys Val Asn Gly Val Thr Tyr Gln Gln
Asn Cys Gln Ala Gly Leu 450 455 460Val Phe Asp Thr Ser Cys Asp Cys
Cys Asn Trp Ala465 470 4756476PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptide 6Met Thr Lys Leu Ile Leu
Leu Thr Gly Leu Val Leu Ile Leu Asn Leu1 5 10 15Gln Leu Gly Ser Ala
Tyr Gln Leu Thr Cys Tyr Phe
Thr Asn Trp Ala 20 25 30Gln Tyr Arg Pro Gly Leu Gly Arg Phe Met Pro
Asp Asp Ile Asn Pro 35 40 45Cys Leu Cys Thr His Leu Ile Tyr Ala Phe
Ala Gly Met Gln Asn Asn 50 55 60Glu Ile Thr Thr Ile Glu Trp Asn Asp
Val Thr Leu Tyr Gln Ala Phe65 70 75 80Asn Gly Leu Lys Asn Lys Asn
Ser Gln Leu Lys Thr Leu Leu Ala Ile 85 90 95Gly Gly Trp Asn Phe Gly
Thr Ala Pro Phe Thr Ala Met Val Ser Thr 100 105 110Pro Glu Asn Arg
Gln Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg 115 120 125Gln Tyr
Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser 130 135
140Arg Gly Ser Pro Pro Gln Asp Lys His Leu Phe Thr Val Leu Val
Gln145 150 155 160Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln
Ile Asn Lys Pro 165 170 175Arg Leu Met Val Thr Ala Ala Val Ala Ala
Gly Ile Ser Asn Ile Gln 180 185 190Ser Gly Tyr Glu Ile Pro Gln Leu
Ser Gln Tyr Leu Asp Tyr Ile His 195 200 205Val Met Thr Tyr Asp Leu
His Gly Ser Trp Glu Gly Tyr Thr Gly Glu 210 215 220Asn Ser Pro Leu
Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Thr Tyr225 230 235 240Leu
Asn Val Asp Tyr Ala Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro 245 250
255Ala Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile
260 265 270Leu Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro Thr Ser
Gly Ala 275 280 285Gly Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile
Trp Ala Tyr Tyr 290 295 300Glu Ile Cys Thr Phe Leu Lys Asn Gly Ala
Thr Gln Gly Trp Asp Ala305 310 315 320Pro Gln Glu Val Pro Tyr Ala
Tyr Gln Gly Asn Val Trp Val Gly Tyr 325 330 335Asp Asn Ile Lys Ser
Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn 340 345 350Lys Phe Gly
Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr 355 360 365Gly
Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys 370 375
380Lys Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln
Pro385 390 395 400Ile Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly
Asn Gly Ser Gly 405 410 415Ser Ser Ser Ser Gly Gly Ser Ser Gly Gly
Ser Gly Phe Cys Ala Val 420 425 430Arg Ala Asn Gly Leu Tyr Pro Val
Ala Asn Asn Arg Asn Ala Phe Trp 435 440 445His Cys Val Asn Gly Val
Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu 450 455 460Val Phe Asp Thr
Ser Cys Asp Cys Cys Asn Trp Ala465 470 4757455PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
7Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly1 5
10 15Leu Gly Arg Phe Met Pro Asp Asn Ile Asp Pro Cys Leu Cys Thr
His 20 25 30Leu Ile Tyr Ala Phe Ala Gly Arg Gln Asn Asn Glu Ile Thr
Thr Ile 35 40 45Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly
Leu Lys Asn 50 55 60Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly
Gly Trp Asn Phe65 70 75 80Gly Thr Ala Pro Phe Thr Ala Met Val Ser
Thr Pro Glu Asn Arg Gln 85 90 95Thr Phe Ile Thr Ser Val Ile Lys Phe
Leu Arg Gln Tyr Glu Phe Asp 100 105 110Gly Leu Asp Phe Asp Trp Glu
Tyr Pro Gly Ser Arg Gly Ser Pro Pro 115 120 125Gln Asp Lys His Leu
Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala 130 135 140Phe Glu Gln
Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met Val Thr145 150 155
160Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile
165 170 175Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val Met Thr
Tyr Asp 180 185 190Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn
Ser Pro Leu Tyr 195 200 205Lys Tyr Pro Thr Asp Thr Gly Ser Asn Thr
Tyr Leu Asn Val Asp Tyr 210 215 220Val Met Asn Tyr Trp Lys Asp Asn
Gly Ala Pro Ala Glu Lys Leu Ile225 230 235 240Val Gly Phe Pro Thr
Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser 245 250 255Asn Thr Gly
Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala Gly Pro 260 265 270Tyr
Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 275 280
285Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro
290 295 300Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Ile
Lys Ser305 310 315 320Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn
Lys Phe Gly Gly Ala 325 330 335Met Val Trp Ala Ile Asp Leu Asp Asp
Phe Thr Gly Thr Phe Cys Asn 340 345 350Gln Gly Lys Phe Pro Leu Ile
Ser Thr Leu Lys Lys Ala Leu Gly Leu 355 360 365Gln Ser Ala Ser Cys
Thr Ala Pro Ala Gln Pro Ile Glu Pro Ile Thr 370 375 380Ala Ala Pro
Ser Gly Ser Gly Asn Gly Ser Gly Ser Ser Ser Ser Gly385 390 395
400Gly Ser Ser Gly Gly Ser Gly Phe Cys Ala Val Arg Ala Asn Gly Leu
405 410 415Tyr Pro Val Ala Asn Asn Arg Asn Ala Phe Trp His Cys Val
Asn Gly 420 425 430Val Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu Val
Phe Asp Thr Ser 435 440 445Cys Asp Cys Cys Asn Trp Ala 450
4558455PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptide 8Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala
Gln Tyr Arg Pro Gly1 5 10 15Leu Gly Arg Phe Met Pro Asp Asn Ile Asp
Pro Cys Leu Cys Thr His 20 25 30Leu Ile Tyr Ala Phe Ala Gly Arg Gln
Asn Asn Glu Ile Thr Thr Ile 35 40 45Glu Trp Asn Asp Val Thr Leu Tyr
Gln Ala Phe Asn Gly Leu Lys Asn 50 55 60Lys Asn Ser Gln Leu Lys Thr
Leu Leu Ala Ile Gly Gly Trp Asn Phe65 70 75 80Gly Thr Ala Pro Phe
Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln 85 90 95Thr Phe Ile Thr
Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe Asp 100 105 110Gly Leu
Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly Ser Pro Pro 115 120
125Gln Asp Lys His Leu Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala
130 135 140Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met
Val Thr145 150 155 160Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln
Ser Gly Tyr Glu Ile 165 170 175Pro Gln Leu Ser Gln Tyr Leu Asp Tyr
Ile His Val Met Thr Tyr Asp 180 185 190Leu His Gly Ser Trp Glu Gly
Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 195 200 205Lys Tyr Pro Thr Asp
Thr Gly Ser Asn Ala Tyr Leu Asn Val Asp Tyr 210 215 220Ala Met Asn
Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys Leu Ile225 230 235
240Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser
245 250 255Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala
Gly Pro 260 265 270Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu
Ile Cys Thr Phe 275 280 285Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp
Ala Pro Gln Glu Val Pro 290 295 300Tyr Ala Tyr Gln Gly Asn Val Trp
Val Gly Tyr Asp Asn Ile Lys Ser305 310 315 320Phe Asp Ile Lys Ala
Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala 325 330 335Met Val Trp
Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe Cys Asn 340 345 350Gln
Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys Ala Leu Gly Leu 355 360
365Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro Ile Glu Pro Ile Thr
370 375 380Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly Ser Ser Ser
Ser Gly385 390 395 400Gly Ser Ser Gly Gly Ser Gly Phe Cys Ala Val
Arg Ala Asn Gly Leu 405 410 415Tyr Pro Val Ala Asn Asn Arg Asn Ala
Phe Trp His Cys Val Asn Gly 420 425 430Val Thr Tyr Gln Gln Asn Cys
Gln Ala Gly Leu Val Phe Asp Thr Ser 435 440 445Cys Asp Cys Cys Asn
Trp Ala 450 4559455PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptide 9Tyr Gln Leu Thr Cys Tyr Phe Thr Asn
Trp Ala Gln Tyr Arg Pro Gly1 5 10 15Leu Gly Arg Phe Met Pro Asp Asn
Ile Asp Pro Cys Leu Cys Thr His 20 25 30Leu Ile Tyr Ala Phe Ala Gly
Arg Gln Asn Asn Glu Ile Thr Thr Ile 35 40 45Glu Trp Asn Asp Val Thr
Leu Tyr Gln Ala Phe Asn Gly Leu Lys Asn 50 55 60Lys Asn Ser Gln Leu
Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe65 70 75 80Gly Thr Ala
Pro Phe Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln 85 90 95Thr Phe
Ile Thr Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe Asp 100 105
110Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly Ser Pro Pro
115 120 125Gln Asp Lys His Leu Phe Thr Val Leu Val Gln Glu Met Arg
Glu Ala 130 135 140Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg
Leu Met Val Thr145 150 155 160Ala Ala Val Ala Ala Gly Ile Ser Asn
Ile Gln Ser Gly Tyr Glu Ile 165 170 175Pro Gln Leu Ser Gln Tyr Leu
Asp Tyr Ile His Val Met Thr Tyr Asp 180 185 190Leu His Gly Ser Trp
Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 195 200 205Lys Tyr Pro
Thr Asp Thr Gly Ser Asn Thr Tyr Leu Asn Val Asp Tyr 210 215 220Ala
Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys Leu Ile225 230
235 240Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu Ser Asn Pro
Ser 245 250 255Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro
Ala Gly Pro 260 265 270Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr
Glu Ile Cys Thr Phe 275 280 285Leu Lys Asn Gly Ala Thr Gln Gly Trp
Asp Ala Pro Gln Glu Val Pro 290 295 300Tyr Ala Tyr Gln Gly Asn Val
Trp Val Gly Tyr Asp Asn Ile Lys Ser305 310 315 320Phe Asp Ile Lys
Ala Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala 325 330 335Met Val
Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe Cys Asn 340 345
350Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys Ala Leu Gly Leu
355 360 365Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro Ile Glu Pro
Ile Thr 370 375 380Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly Ser
Ser Ser Ser Gly385 390 395 400Gly Ser Ser Gly Gly Ser Gly Phe Cys
Ala Val Arg Ala Asn Gly Leu 405 410 415Tyr Pro Val Ala Asn Asn Arg
Asn Ala Phe Trp His Cys Val Asn Gly 420 425 430Val Thr Tyr Gln Gln
Asn Cys Gln Ala Gly Leu Val Phe Asp Thr Ser 435 440 445Cys Asp Cys
Cys Asn Trp Ala 450 45510455PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptide 10Tyr Gln Leu Thr Cys Tyr
Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly1 5 10 15Leu Gly Arg Phe Met
Pro Asp Asp Ile Asp Pro Cys Leu Cys Thr His 20 25 30Leu Ile Tyr Ala
Phe Ala Gly Arg Gln Asn Asn Glu Ile Thr Thr Ile 35 40 45Glu Trp Asn
Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly Leu Lys Asn 50 55 60Lys Asn
Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe65 70 75
80Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln
85 90 95Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe
Asp 100 105 110Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly
Ser Pro Pro 115 120 125Gln Asp Lys His Leu Phe Thr Val Leu Val Gln
Glu Met Arg Glu Ala 130 135 140Phe Glu Gln Glu Ala Lys Gln Ile Asn
Lys Pro Arg Leu Met Val Thr145 150 155 160Ala Ala Val Ala Ala Gly
Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile 165 170 175Pro Gln Leu Ser
Gln Tyr Leu Asp Tyr Ile His Val Met Thr Tyr Asp 180 185 190Leu His
Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 195 200
205Lys Tyr Pro Thr Asp Thr Gly Ser Asn Thr Tyr Leu Asn Val Asp Tyr
210 215 220Ala Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys
Leu Ile225 230 235 240Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile
Leu Ser Asn Pro Ser 245 250 255Asn Thr Gly Ile Gly Ala Pro Thr Ser
Gly Ala Gly Pro Ala Gly Pro 260 265 270Tyr Ala Lys Glu Ser Gly Ile
Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 275 280 285Leu Lys Asn Gly Ala
Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro 290 295 300Tyr Ala Tyr
Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Ile Lys Ser305 310 315
320Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala
325 330 335Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe
Cys Asn 340 345 350Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys
Ala Leu Gly Leu 355 360 365Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln
Pro Ile Glu Pro Ile Thr 370 375 380Ala Ala Pro Ser Gly Ser Gly Asn
Gly Ser Gly Ser Ser Ser Ser Gly385 390 395 400Gly Ser Ser Gly Gly
Ser Gly Phe Cys Ala Val Arg Ala Asn Gly Leu 405 410 415Tyr Pro Val
Ala Asn Asn Arg Asn Ala Phe Trp His Cys Val Asn Gly 420 425 430Val
Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu Val Phe Asp Thr Ser 435 440
445Cys Asp Cys Cys Asn Trp Ala 450 45511455PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
11Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly1
5 10 15Leu Gly Arg Phe Met Pro Asp Asp Ile Asn Pro Cys Leu Cys Thr
His 20 25 30Leu Ile Tyr Ala Phe Ala Gly Arg Gln Asn Asn Glu Ile Thr
Thr Ile 35 40 45Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly
Leu Lys Asn 50 55 60Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly
Gly Trp Asn Phe65 70 75 80Gly Thr Ala Pro Phe Thr Ala Met Val Ser
Thr Pro Glu Asn Arg Gln 85 90 95Thr Phe Ile Thr Ser Val Ile Lys Phe
Leu Arg Gln Tyr Glu Phe Asp 100 105 110Gly Leu Asp Phe Asp Trp Glu
Tyr Pro Gly Ser Arg Gly Ser Pro Pro 115 120 125Gln Asp Lys His Leu
Phe Thr Val Leu Val Gln Glu Met Arg
Glu Ala 130 135 140Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg
Leu Met Val Thr145 150 155 160Ala Ala Val Ala Ala Gly Ile Ser Asn
Ile Gln Ser Gly Tyr Glu Ile 165 170 175Pro Gln Leu Ser Gln Tyr Leu
Asp Tyr Ile His Val Met Thr Tyr Asp 180 185 190Leu His Gly Ser Trp
Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 195 200 205Lys Tyr Pro
Thr Asp Thr Gly Ser Asn Thr Tyr Leu Asn Val Asp Tyr 210 215 220Ala
Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys Leu Ile225 230
235 240Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu Ser Asn Pro
Ser 245 250 255Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro
Ala Gly Pro 260 265 270Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr
Glu Ile Cys Thr Phe 275 280 285Leu Lys Asn Gly Ala Thr Gln Gly Trp
Asp Ala Pro Gln Glu Val Pro 290 295 300Tyr Ala Tyr Gln Gly Asn Val
Trp Val Gly Tyr Asp Asn Ile Lys Ser305 310 315 320Phe Asp Ile Lys
Ala Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala 325 330 335Met Val
Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe Cys Asn 340 345
350Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys Ala Leu Gly Leu
355 360 365Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro Ile Glu Pro
Ile Thr 370 375 380Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly Ser
Ser Ser Ser Gly385 390 395 400Gly Ser Ser Gly Gly Ser Gly Phe Cys
Ala Val Arg Ala Asn Gly Leu 405 410 415Tyr Pro Val Ala Asn Asn Arg
Asn Ala Phe Trp His Cys Val Asn Gly 420 425 430Val Thr Tyr Gln Gln
Asn Cys Gln Ala Gly Leu Val Phe Asp Thr Ser 435 440 445Cys Asp Cys
Cys Asn Trp Ala 450 45512455PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptide 12Tyr Gln Leu Thr Cys Tyr
Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly1 5 10 15Leu Gly Arg Phe Met
Pro Asp Asp Ile Asn Pro Cys Leu Cys Thr His 20 25 30Leu Ile Tyr Ala
Phe Ala Gly Met Gln Asn Asn Glu Ile Thr Thr Ile 35 40 45Glu Trp Asn
Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly Leu Lys Asn 50 55 60Lys Asn
Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe65 70 75
80Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln
85 90 95Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe
Asp 100 105 110Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly
Ser Pro Pro 115 120 125Gln Asp Lys His Leu Phe Thr Val Leu Val Gln
Glu Met Arg Glu Ala 130 135 140Phe Glu Gln Glu Ala Lys Gln Ile Asn
Lys Pro Arg Leu Met Val Thr145 150 155 160Ala Ala Val Ala Ala Gly
Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile 165 170 175Pro Gln Leu Ser
Gln Tyr Leu Asp Tyr Ile His Val Met Thr Tyr Asp 180 185 190Leu His
Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 195 200
205Lys Tyr Pro Thr Asp Thr Gly Ser Asn Thr Tyr Leu Asn Val Asp Tyr
210 215 220Ala Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys
Leu Ile225 230 235 240Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile
Leu Ser Asn Pro Ser 245 250 255Asn Thr Gly Ile Gly Ala Pro Thr Ser
Gly Ala Gly Pro Ala Gly Pro 260 265 270Tyr Ala Lys Glu Ser Gly Ile
Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 275 280 285Leu Lys Asn Gly Ala
Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro 290 295 300Tyr Ala Tyr
Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Ile Lys Ser305 310 315
320Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala
325 330 335Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe
Cys Asn 340 345 350Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys
Ala Leu Gly Leu 355 360 365Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln
Pro Ile Glu Pro Ile Thr 370 375 380Ala Ala Pro Ser Gly Ser Gly Asn
Gly Ser Gly Ser Ser Ser Ser Gly385 390 395 400Gly Ser Ser Gly Gly
Ser Gly Phe Cys Ala Val Arg Ala Asn Gly Leu 405 410 415Tyr Pro Val
Ala Asn Asn Arg Asn Ala Phe Trp His Cys Val Asn Gly 420 425 430Val
Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu Val Phe Asp Thr Ser 435 440
445Cys Asp Cys Cys Asn Trp Ala 450 45513387PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
13Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly1
5 10 15Leu Gly Arg Phe Met Pro Asp Asn Ile Asp Pro Cys Leu Cys Thr
His 20 25 30Leu Ile Tyr Ala Phe Ala Gly Arg Gln Asn Asn Glu Ile Thr
Thr Ile 35 40 45Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly
Leu Lys Asn 50 55 60Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly
Gly Trp Asn Phe65 70 75 80Gly Thr Ala Pro Phe Thr Ala Met Val Ser
Thr Pro Glu Asn Arg Gln 85 90 95Thr Phe Ile Thr Ser Val Ile Lys Phe
Leu Arg Gln Tyr Glu Phe Asp 100 105 110Gly Leu Asp Phe Asp Trp Glu
Tyr Pro Gly Ser Arg Gly Ser Pro Pro 115 120 125Gln Asp Lys His Leu
Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala 130 135 140Phe Glu Gln
Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met Val Thr145 150 155
160Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile
165 170 175Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val Met Thr
Tyr Asp 180 185 190Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn
Ser Pro Leu Tyr 195 200 205Lys Tyr Pro Thr Asp Thr Gly Ser Asn Thr
Tyr Leu Asn Val Asp Tyr 210 215 220Val Met Asn Tyr Trp Lys Asp Asn
Gly Ala Pro Ala Glu Lys Leu Ile225 230 235 240Val Gly Phe Pro Thr
Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser 245 250 255Asn Thr Gly
Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala Gly Pro 260 265 270Tyr
Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 275 280
285Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro
290 295 300Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Ile
Lys Ser305 310 315 320Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn
Lys Phe Gly Gly Ala 325 330 335Met Val Trp Ala Ile Asp Leu Asp Asp
Phe Thr Gly Thr Phe Cys Asn 340 345 350Gln Gly Lys Phe Pro Leu Ile
Ser Thr Leu Lys Lys Ala Leu Gly Leu 355 360 365Gln Ser Ala Ser Cys
Thr Ala Pro Ala Gln Pro Ile Glu Pro Ile Thr 370 375 380Ala Ala
Pro38514387PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptide 14Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala
Gln Tyr Arg Pro Gly1 5 10 15Leu Gly Arg Phe Met Pro Asp Asn Ile Asp
Pro Cys Leu Cys Thr His 20 25 30Leu Ile Tyr Ala Phe Ala Gly Arg Gln
Asn Asn Glu Ile Thr Thr Ile 35 40 45Glu Trp Asn Asp Val Thr Leu Tyr
Gln Ala Phe Asn Gly Leu Lys Asn 50 55 60Lys Asn Ser Gln Leu Lys Thr
Leu Leu Ala Ile Gly Gly Trp Asn Phe65 70 75 80Gly Thr Ala Pro Phe
Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln 85 90 95Thr Phe Ile Thr
Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe Asp 100 105 110Gly Leu
Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly Ser Pro Pro 115 120
125Gln Asp Lys His Leu Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala
130 135 140Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met
Val Thr145 150 155 160Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln
Ser Gly Tyr Glu Ile 165 170 175Pro Gln Leu Ser Gln Tyr Leu Asp Tyr
Ile His Val Met Thr Tyr Asp 180 185 190Leu His Gly Ser Trp Glu Gly
Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 195 200 205Lys Tyr Pro Thr Asp
Thr Gly Ser Asn Ala Tyr Leu Asn Val Asp Tyr 210 215 220Ala Met Asn
Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys Leu Ile225 230 235
240Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser
245 250 255Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala
Gly Pro 260 265 270Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu
Ile Cys Thr Phe 275 280 285Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp
Ala Pro Gln Glu Val Pro 290 295 300Tyr Ala Tyr Gln Gly Asn Val Trp
Val Gly Tyr Asp Asn Ile Lys Ser305 310 315 320Phe Asp Ile Lys Ala
Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala 325 330 335Met Val Trp
Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe Cys Asn 340 345 350Gln
Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys Ala Leu Gly Leu 355 360
365Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro Ile Glu Pro Ile Thr
370 375 380Ala Ala Pro38515387PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptide 15Tyr Gln Leu Thr Cys Tyr
Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly1 5 10 15Leu Gly Arg Phe Met
Pro Asp Asn Ile Asp Pro Cys Leu Cys Thr His 20 25 30Leu Ile Tyr Ala
Phe Ala Gly Arg Gln Asn Asn Glu Ile Thr Thr Ile 35 40 45Glu Trp Asn
Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly Leu Lys Asn 50 55 60Lys Asn
Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe65 70 75
80Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln
85 90 95Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe
Asp 100 105 110Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly
Ser Pro Pro 115 120 125Gln Asp Lys His Leu Phe Thr Val Leu Val Gln
Glu Met Arg Glu Ala 130 135 140Phe Glu Gln Glu Ala Lys Gln Ile Asn
Lys Pro Arg Leu Met Val Thr145 150 155 160Ala Ala Val Ala Ala Gly
Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile 165 170 175Pro Gln Leu Ser
Gln Tyr Leu Asp Tyr Ile His Val Met Thr Tyr Asp 180 185 190Leu His
Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 195 200
205Lys Tyr Pro Thr Asp Thr Gly Ser Asn Thr Tyr Leu Asn Val Asp Tyr
210 215 220Ala Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys
Leu Ile225 230 235 240Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile
Leu Ser Asn Pro Ser 245 250 255Asn Thr Gly Ile Gly Ala Pro Thr Ser
Gly Ala Gly Pro Ala Gly Pro 260 265 270Tyr Ala Lys Glu Ser Gly Ile
Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 275 280 285Leu Lys Asn Gly Ala
Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro 290 295 300Tyr Ala Tyr
Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Ile Lys Ser305 310 315
320Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala
325 330 335Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe
Cys Asn 340 345 350Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys
Ala Leu Gly Leu 355 360 365Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln
Pro Ile Glu Pro Ile Thr 370 375 380Ala Ala Pro38516387PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
16Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly1
5 10 15Leu Gly Arg Phe Met Pro Asp Asp Ile Asp Pro Cys Leu Cys Thr
His 20 25 30Leu Ile Tyr Ala Phe Ala Gly Arg Gln Asn Asn Glu Ile Thr
Thr Ile 35 40 45Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly
Leu Lys Asn 50 55 60Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly
Gly Trp Asn Phe65 70 75 80Gly Thr Ala Pro Phe Thr Ala Met Val Ser
Thr Pro Glu Asn Arg Gln 85 90 95Thr Phe Ile Thr Ser Val Ile Lys Phe
Leu Arg Gln Tyr Glu Phe Asp 100 105 110Gly Leu Asp Phe Asp Trp Glu
Tyr Pro Gly Ser Arg Gly Ser Pro Pro 115 120 125Gln Asp Lys His Leu
Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala 130 135 140Phe Glu Gln
Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met Val Thr145 150 155
160Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile
165 170 175Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val Met Thr
Tyr Asp 180 185 190Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn
Ser Pro Leu Tyr 195 200 205Lys Tyr Pro Thr Asp Thr Gly Ser Asn Thr
Tyr Leu Asn Val Asp Tyr 210 215 220Ala Met Asn Tyr Trp Lys Asp Asn
Gly Ala Pro Ala Glu Lys Leu Ile225 230 235 240Val Gly Phe Pro Thr
Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser 245 250 255Asn Thr Gly
Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala Gly Pro 260 265 270Tyr
Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 275 280
285Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro
290 295 300Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Ile
Lys Ser305 310 315 320Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn
Lys Phe Gly Gly Ala 325 330 335Met Val Trp Ala Ile Asp Leu Asp Asp
Phe Thr Gly Thr Phe Cys Asn 340 345 350Gln Gly Lys Phe Pro Leu Ile
Ser Thr Leu Lys Lys Ala Leu Gly Leu 355 360 365Gln Ser Ala Ser Cys
Thr Ala Pro Ala Gln Pro Ile Glu Pro Ile Thr 370 375 380Ala Ala
Pro38517387PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptide 17Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala
Gln Tyr Arg Pro Gly1 5 10 15Leu Gly Arg Phe Met Pro Asp Asp Ile Asn
Pro Cys Leu Cys Thr His 20 25 30Leu Ile Tyr Ala Phe Ala Gly Arg Gln
Asn Asn Glu Ile Thr Thr Ile 35 40 45Glu Trp Asn Asp Val Thr Leu Tyr
Gln Ala Phe Asn Gly Leu Lys Asn 50 55 60Lys Asn Ser Gln Leu Lys Thr
Leu Leu Ala Ile Gly Gly Trp Asn Phe65 70 75 80Gly Thr Ala Pro
Phe
Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln 85 90 95Thr Phe Ile Thr
Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe Asp 100 105 110Gly Leu
Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly Ser Pro Pro 115 120
125Gln Asp Lys His Leu Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala
130 135 140Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met
Val Thr145 150 155 160Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln
Ser Gly Tyr Glu Ile 165 170 175Pro Gln Leu Ser Gln Tyr Leu Asp Tyr
Ile His Val Met Thr Tyr Asp 180 185 190Leu His Gly Ser Trp Glu Gly
Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 195 200 205Lys Tyr Pro Thr Asp
Thr Gly Ser Asn Thr Tyr Leu Asn Val Asp Tyr 210 215 220Ala Met Asn
Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys Leu Ile225 230 235
240Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser
245 250 255Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala
Gly Pro 260 265 270Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu
Ile Cys Thr Phe 275 280 285Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp
Ala Pro Gln Glu Val Pro 290 295 300Tyr Ala Tyr Gln Gly Asn Val Trp
Val Gly Tyr Asp Asn Ile Lys Ser305 310 315 320Phe Asp Ile Lys Ala
Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala 325 330 335Met Val Trp
Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe Cys Asn 340 345 350Gln
Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys Ala Leu Gly Leu 355 360
365Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro Ile Glu Pro Ile Thr
370 375 380Ala Ala Pro38518387PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptide 18Tyr Gln Leu Thr Cys Tyr
Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly1 5 10 15Leu Gly Arg Phe Met
Pro Asp Asp Ile Asn Pro Cys Leu Cys Thr His 20 25 30Leu Ile Tyr Ala
Phe Ala Gly Met Gln Asn Asn Glu Ile Thr Thr Ile 35 40 45Glu Trp Asn
Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly Leu Lys Asn 50 55 60Lys Asn
Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe65 70 75
80Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln
85 90 95Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe
Asp 100 105 110Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly
Ser Pro Pro 115 120 125Gln Asp Lys His Leu Phe Thr Val Leu Val Gln
Glu Met Arg Glu Ala 130 135 140Phe Glu Gln Glu Ala Lys Gln Ile Asn
Lys Pro Arg Leu Met Val Thr145 150 155 160Ala Ala Val Ala Ala Gly
Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile 165 170 175Pro Gln Leu Ser
Gln Tyr Leu Asp Tyr Ile His Val Met Thr Tyr Asp 180 185 190Leu His
Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 195 200
205Lys Tyr Pro Thr Asp Thr Gly Ser Asn Thr Tyr Leu Asn Val Asp Tyr
210 215 220Ala Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys
Leu Ile225 230 235 240Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile
Leu Ser Asn Pro Ser 245 250 255Asn Thr Gly Ile Gly Ala Pro Thr Ser
Gly Ala Gly Pro Ala Gly Pro 260 265 270Tyr Ala Lys Glu Ser Gly Ile
Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 275 280 285Leu Lys Asn Gly Ala
Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro 290 295 300Tyr Ala Tyr
Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Ile Lys Ser305 310 315
320Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala
325 330 335Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe
Cys Asn 340 345 350Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys
Ala Leu Gly Leu 355 360 365Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln
Pro Ile Glu Pro Ile Thr 370 375 380Ala Ala Pro38519377PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
19Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly1
5 10 15Leu Gly Arg Phe Met Pro Asp Asn Ile Asp Pro Cys Leu Cys Thr
His 20 25 30Leu Ile Tyr Ala Phe Ala Gly Arg Gln Asn Asn Glu Ile Thr
Thr Ile 35 40 45Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly
Leu Lys Asn 50 55 60Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly
Gly Trp Asn Phe65 70 75 80Gly Thr Ala Pro Phe Thr Ala Met Val Ser
Thr Pro Glu Asn Arg Gln 85 90 95Thr Phe Ile Thr Ser Val Ile Lys Phe
Leu Arg Gln Tyr Glu Phe Asp 100 105 110Gly Leu Asp Phe Asp Trp Glu
Tyr Pro Gly Ser Arg Gly Ser Pro Pro 115 120 125Gln Asp Lys His Leu
Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala 130 135 140Phe Glu Gln
Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met Val Thr145 150 155
160Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile
165 170 175Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val Met Thr
Tyr Asp 180 185 190Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn
Ser Pro Leu Tyr 195 200 205Lys Tyr Pro Thr Asp Thr Gly Ser Asn Thr
Tyr Leu Asn Val Asp Tyr 210 215 220Val Met Asn Tyr Trp Lys Asp Asn
Gly Ala Pro Ala Glu Lys Leu Ile225 230 235 240Val Gly Phe Pro Thr
Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser 245 250 255Asn Thr Gly
Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala Gly Pro 260 265 270Tyr
Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 275 280
285Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro
290 295 300Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Ile
Lys Ser305 310 315 320Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn
Lys Phe Gly Gly Ala 325 330 335Met Val Trp Ala Ile Asp Leu Asp Asp
Phe Thr Gly Thr Phe Cys Asn 340 345 350Gln Gly Lys Phe Pro Leu Ile
Ser Thr Leu Lys Lys Ala Leu Gly Leu 355 360 365Gln Ser Ala Ser Cys
Thr Ala Pro Ala 370 37520377PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptide 20Tyr Gln Leu Thr Cys Tyr
Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly1 5 10 15Leu Gly Arg Phe Met
Pro Asp Asn Ile Asp Pro Cys Leu Cys Thr His 20 25 30Leu Ile Tyr Ala
Phe Ala Gly Arg Gln Asn Asn Glu Ile Thr Thr Ile 35 40 45Glu Trp Asn
Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly Leu Lys Asn 50 55 60Lys Asn
Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe65 70 75
80Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln
85 90 95Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe
Asp 100 105 110Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly
Ser Pro Pro 115 120 125Gln Asp Lys His Leu Phe Thr Val Leu Val Gln
Glu Met Arg Glu Ala 130 135 140Phe Glu Gln Glu Ala Lys Gln Ile Asn
Lys Pro Arg Leu Met Val Thr145 150 155 160Ala Ala Val Ala Ala Gly
Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile 165 170 175Pro Gln Leu Ser
Gln Tyr Leu Asp Tyr Ile His Val Met Thr Tyr Asp 180 185 190Leu His
Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 195 200
205Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr Leu Asn Val Asp Tyr
210 215 220Ala Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys
Leu Ile225 230 235 240Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile
Leu Ser Asn Pro Ser 245 250 255Asn Thr Gly Ile Gly Ala Pro Thr Ser
Gly Ala Gly Pro Ala Gly Pro 260 265 270Tyr Ala Lys Glu Ser Gly Ile
Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 275 280 285Leu Lys Asn Gly Ala
Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro 290 295 300Tyr Ala Tyr
Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Ile Lys Ser305 310 315
320Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala
325 330 335Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe
Cys Asn 340 345 350Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys
Ala Leu Gly Leu 355 360 365Gln Ser Ala Ser Cys Thr Ala Pro Ala 370
37521377PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptide 21Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala
Gln Tyr Arg Pro Gly1 5 10 15Leu Gly Arg Phe Met Pro Asp Asn Ile Asp
Pro Cys Leu Cys Thr His 20 25 30Leu Ile Tyr Ala Phe Ala Gly Arg Gln
Asn Asn Glu Ile Thr Thr Ile 35 40 45Glu Trp Asn Asp Val Thr Leu Tyr
Gln Ala Phe Asn Gly Leu Lys Asn 50 55 60Lys Asn Ser Gln Leu Lys Thr
Leu Leu Ala Ile Gly Gly Trp Asn Phe65 70 75 80Gly Thr Ala Pro Phe
Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln 85 90 95Thr Phe Ile Thr
Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe Asp 100 105 110Gly Leu
Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly Ser Pro Pro 115 120
125Gln Asp Lys His Leu Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala
130 135 140Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met
Val Thr145 150 155 160Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln
Ser Gly Tyr Glu Ile 165 170 175Pro Gln Leu Ser Gln Tyr Leu Asp Tyr
Ile His Val Met Thr Tyr Asp 180 185 190Leu His Gly Ser Trp Glu Gly
Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 195 200 205Lys Tyr Pro Thr Asp
Thr Gly Ser Asn Thr Tyr Leu Asn Val Asp Tyr 210 215 220Ala Met Asn
Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys Leu Ile225 230 235
240Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser
245 250 255Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala
Gly Pro 260 265 270Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu
Ile Cys Thr Phe 275 280 285Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp
Ala Pro Gln Glu Val Pro 290 295 300Tyr Ala Tyr Gln Gly Asn Val Trp
Val Gly Tyr Asp Asn Ile Lys Ser305 310 315 320Phe Asp Ile Lys Ala
Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala 325 330 335Met Val Trp
Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe Cys Asn 340 345 350Gln
Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys Ala Leu Gly Leu 355 360
365Gln Ser Ala Ser Cys Thr Ala Pro Ala 370 37522377PRTArtificial
SequenceDescription of Artificial Sequence Synthetic polypeptide
22Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly1
5 10 15Leu Gly Arg Phe Met Pro Asp Asp Ile Asp Pro Cys Leu Cys Thr
His 20 25 30Leu Ile Tyr Ala Phe Ala Gly Arg Gln Asn Asn Glu Ile Thr
Thr Ile 35 40 45Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly
Leu Lys Asn 50 55 60Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly
Gly Trp Asn Phe65 70 75 80Gly Thr Ala Pro Phe Thr Ala Met Val Ser
Thr Pro Glu Asn Arg Gln 85 90 95Thr Phe Ile Thr Ser Val Ile Lys Phe
Leu Arg Gln Tyr Glu Phe Asp 100 105 110Gly Leu Asp Phe Asp Trp Glu
Tyr Pro Gly Ser Arg Gly Ser Pro Pro 115 120 125Gln Asp Lys His Leu
Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala 130 135 140Phe Glu Gln
Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met Val Thr145 150 155
160Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile
165 170 175Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His Val Met Thr
Tyr Asp 180 185 190Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn
Ser Pro Leu Tyr 195 200 205Lys Tyr Pro Thr Asp Thr Gly Ser Asn Thr
Tyr Leu Asn Val Asp Tyr 210 215 220Ala Met Asn Tyr Trp Lys Asp Asn
Gly Ala Pro Ala Glu Lys Leu Ile225 230 235 240Val Gly Phe Pro Thr
Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser 245 250 255Asn Thr Gly
Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala Gly Pro 260 265 270Tyr
Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 275 280
285Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro
290 295 300Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Ile
Lys Ser305 310 315 320Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn
Lys Phe Gly Gly Ala 325 330 335Met Val Trp Ala Ile Asp Leu Asp Asp
Phe Thr Gly Thr Phe Cys Asn 340 345 350Gln Gly Lys Phe Pro Leu Ile
Ser Thr Leu Lys Lys Ala Leu Gly Leu 355 360 365Gln Ser Ala Ser Cys
Thr Ala Pro Ala 370 37523377PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptide 23Tyr Gln Leu Thr Cys Tyr
Phe Thr Asn Trp Ala Gln Tyr Arg Pro Gly1 5 10 15Leu Gly Arg Phe Met
Pro Asp Asp Ile Asn Pro Cys Leu Cys Thr His 20 25 30Leu Ile Tyr Ala
Phe Ala Gly Arg Gln Asn Asn Glu Ile Thr Thr Ile 35 40 45Glu Trp Asn
Asp Val Thr Leu Tyr Gln Ala Phe Asn Gly Leu Lys Asn 50 55 60Lys Asn
Ser Gln Leu Lys Thr Leu Leu Ala Ile Gly Gly Trp Asn Phe65 70 75
80Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln
85 90 95Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe
Asp 100 105 110Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly
Ser Pro Pro 115 120 125Gln Asp Lys His Leu Phe Thr Val Leu Val Gln
Glu Met Arg Glu Ala 130 135 140Phe Glu Gln Glu Ala Lys Gln Ile Asn
Lys Pro Arg Leu Met Val Thr145 150 155 160Ala Ala Val Ala Ala Gly
Ile Ser Asn Ile Gln Ser Gly Tyr Glu Ile 165 170 175Pro Gln Leu Ser
Gln Tyr Leu Asp Tyr Ile His Val Met Thr Tyr Asp 180 185 190Leu His
Gly Ser Trp Glu Gly Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 195
200 205Lys Tyr Pro Thr Asp Thr Gly Ser Asn Thr Tyr Leu Asn Val Asp
Tyr 210 215 220Ala Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu
Lys Leu Ile225 230 235 240Val Gly Phe Pro Thr Tyr Gly His Asn Phe
Ile Leu Ser Asn Pro Ser 245 250 255Asn Thr Gly Ile Gly Ala Pro Thr
Ser Gly Ala Gly Pro Ala Gly Pro 260 265 270Tyr Ala Lys Glu Ser Gly
Ile Trp Ala Tyr Tyr Glu Ile Cys Thr Phe 275 280 285Leu Lys Asn Gly
Ala Thr Gln Gly Trp Asp Ala Pro Gln Glu Val Pro 290 295 300Tyr Ala
Tyr Gln Gly Asn Val Trp Val Gly Tyr Asp Asn Ile Lys Ser305 310 315
320Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala
325 330 335Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe
Cys Asn 340 345 350Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys
Ala Leu Gly Leu 355 360 365Gln Ser Ala Ser Cys Thr Ala Pro Ala 370
37524377PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptide 24Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala
Gln Tyr Arg Pro Gly1 5 10 15Leu Gly Arg Phe Met Pro Asp Asp Ile Asn
Pro Cys Leu Cys Thr His 20 25 30Leu Ile Tyr Ala Phe Ala Gly Met Gln
Asn Asn Glu Ile Thr Thr Ile 35 40 45Glu Trp Asn Asp Val Thr Leu Tyr
Gln Ala Phe Asn Gly Leu Lys Asn 50 55 60Lys Asn Ser Gln Leu Lys Thr
Leu Leu Ala Ile Gly Gly Trp Asn Phe65 70 75 80Gly Thr Ala Pro Phe
Thr Ala Met Val Ser Thr Pro Glu Asn Arg Gln 85 90 95Thr Phe Ile Thr
Ser Val Ile Lys Phe Leu Arg Gln Tyr Glu Phe Asp 100 105 110Gly Leu
Asp Phe Asp Trp Glu Tyr Pro Gly Ser Arg Gly Ser Pro Pro 115 120
125Gln Asp Lys His Leu Phe Thr Val Leu Val Gln Glu Met Arg Glu Ala
130 135 140Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro Arg Leu Met
Val Thr145 150 155 160Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln
Ser Gly Tyr Glu Ile 165 170 175Pro Gln Leu Ser Gln Tyr Leu Asp Tyr
Ile His Val Met Thr Tyr Asp 180 185 190Leu His Gly Ser Trp Glu Gly
Tyr Thr Gly Glu Asn Ser Pro Leu Tyr 195 200 205Lys Tyr Pro Thr Asp
Thr Gly Ser Asn Thr Tyr Leu Asn Val Asp Tyr 210 215 220Ala Met Asn
Tyr Trp Lys Asp Asn Gly Ala Pro Ala Glu Lys Leu Ile225 230 235
240Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile Leu Ser Asn Pro Ser
245 250 255Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala Gly Pro Ala
Gly Pro 260 265 270Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr Glu
Ile Cys Thr Phe 275 280 285Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp
Ala Pro Gln Glu Val Pro 290 295 300Tyr Ala Tyr Gln Gly Asn Val Trp
Val Gly Tyr Asp Asn Ile Lys Ser305 310 315 320Phe Asp Ile Lys Ala
Gln Trp Leu Lys His Asn Lys Phe Gly Gly Ala 325 330 335Met Val Trp
Ala Ile Asp Leu Asp Asp Phe Thr Gly Thr Phe Cys Asn 340 345 350Gln
Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys Lys Ala Leu Gly Leu 355 360
365Gln Ser Ala Ser Cys Thr Ala Pro Ala 370 375
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