U.S. patent application number 17/351527 was filed with the patent office on 2022-03-24 for red blood cell targeted factor viii and method of using the same. The applicant listed for this patent is Bayer HealthCare LLC. Invention is credited to Peter Bringmann, Alan Brooks, Richard Feldman, Jian-Ming GU, Shaun Lippow, Shujun Yuan.
Application Number | 20220089685 17/351527 |
Document ID | / |
Family ID | 1000006004191 |
Filed Date | 2022-03-24 |
United States Patent Application | 20220089685 |
Kind Code | A1 |
Brooks; Alan ; et al. | March 24, 2022 |
Targeted Factor VIII molecules comprising a Factor VIII linked with at least one domain that specifically binds to a membrane protein on a red blood cell is provided. The disclosed targeted coagulation factors prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.
Inventors: | Brooks; Alan; (Clayton, CA) ; Feldman; Richard; (El Cerrito, CA) ; GU; Jian-Ming; (Lafayette, CA) ; Lippow; Shaun; (San Carlos, CA) ; Yuan; Shujun; (Daly City, CA) ; Bringmann; Peter; (Concord, CA) | ||||||||||
Applicant: |
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Family ID: | 1000006004191 | ||||||||||
Appl. No.: | 17/351527 | ||||||||||
Filed: | June 18, 2021 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
16349794 | May 14, 2019 | 11104718 | ||
PCT/US2017/061509 | Nov 14, 2017 | |||
17351527 | ||||
62422600 | Nov 16, 2016 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | C07K 2317/34 20130101; A61K 2039/505 20130101; C07K 2317/565 20130101; C07K 2317/33 20130101; C07K 14/755 20130101; C07K 2317/94 20130101; C07K 16/2896 20130101; C07K 2319/50 20130101; C07K 2317/24 20130101; C07K 2317/55 20130101; A61P 7/04 20180101; C07K 2319/33 20130101; C07K 2317/92 20130101; C07K 2317/567 20130101; C07K 2317/622 20130101; C07K 2317/64 20130101; C07K 2317/76 20130101; C07K 2319/30 20130101 |
International Class: | C07K 14/755 20060101 C07K014/755; A61P 7/04 20060101 A61P007/04; C07K 16/28 20060101 C07K016/28 |
Sequence CWU 1
1
13312351PRTHomo Sapiens 1Met Gln Ile Glu Leu Ser Thr Cys Phe Phe
Leu Cys Leu Leu Arg Phe1 5 10 15Cys Phe Ser Ala Thr Arg Arg Tyr Tyr
Leu Gly Ala Val Glu Leu Ser 20 25 30Trp Asp Tyr Met Gln Ser Asp Leu
Gly Glu Leu Pro Val Asp Ala Arg 35 40 45Phe Pro Pro Arg Val Pro Lys
Ser Phe Pro Phe Asn Thr Ser Val Val 50 55 60Tyr Lys Lys Thr Leu Phe
Val Glu Phe Thr Val His Leu Phe Asn Ile65 70 75 80Ala Lys Pro Arg
Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 85 90 95Ala Glu Val
Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 100 105 110His
Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 115 120
125Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp
130 135 140Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln
Val Leu145 150 155 160Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu
Cys Leu Thr Tyr Ser 165 170 175Tyr Leu Ser His Val Asp Leu Val Lys
Asp Leu Asn Ser Gly Leu Ile 180 185 190Gly Ala Leu Leu Val Cys Arg
Glu Gly Ser Leu Ala Lys Glu Lys Thr 195 200 205Gln Thr Leu His Lys
Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 210 215 220Lys Ser Trp
His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp225 230 235
240Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr
245 250 255Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys
Ser Val 260 265 270Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu
Val His Ser Ile 275 280 285Phe Leu Glu Gly His Thr Phe Leu Val Arg
Asn His Arg Gln Ala Ser 290 295 300Leu Glu Ile Ser Pro Ile Thr Phe
Leu Thr Ala Gln Thr Leu Leu Met305 310 315 320Asp Leu Gly Gln Phe
Leu Leu Phe Cys His Ile Ser Ser His Gln His 325 330 335Asp Gly Met
Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 340 345 350Gln
Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 355 360
365Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser
370 375 380Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro
Lys Thr385 390 395 400Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp
Trp Asp Tyr Ala Pro 405 410 415Leu Val Leu Ala Pro Asp Asp Arg Ser
Tyr Lys Ser Gln Tyr Leu Asn 420 425 430Asn Gly Pro Gln Arg Ile Gly
Arg Lys Tyr Lys Lys Val Arg Phe Met 435 440 445Ala Tyr Thr Asp Glu
Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 450 455 460Ser Gly Ile
Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu465 470 475
480Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro
485 490 495His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu
Pro Lys 500 505 510Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro
Gly Glu Ile Phe 515 520 525Lys Tyr Lys Trp Thr Val Thr Val Glu Asp
Gly Pro Thr Lys Ser Asp 530 535 540Pro Arg Cys Leu Thr Arg Tyr Tyr
Ser Ser Phe Val Asn Met Glu Arg545 550 555 560Asp Leu Ala Ser Gly
Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 565 570 575Ser Val Asp
Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 580 585 590Ile
Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 595 600
605Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp
610 615 620Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly
Tyr Val625 630 635 640Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His
Glu Val Ala Tyr Trp 645 650 655Tyr Ile Leu Ser Ile Gly Ala Gln Thr
Asp Phe Leu Ser Val Phe Phe 660 665 670Ser Gly Tyr Thr Phe Lys His
Lys Met Val Tyr Glu Asp Thr Leu Thr 675 680 685Leu Phe Pro Phe Ser
Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 690 695 700Gly Leu Trp
Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly705 710 715
720Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp
725 730 735Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu
Ser Lys 740 745 750Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn
Ser Arg His Pro 755 760 765Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr
Thr Ile Pro Glu Asn Asp 770 775 780Ile Glu Lys Thr Asp Pro Trp Phe
Ala His Arg Thr Pro Met Pro Lys785 790 795 800Ile Gln Asn Val Ser
Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 805 810 815Pro Thr Pro
His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 820 825 830Glu
Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 835 840
845Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly
850 855 860Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu
Asn Glu865 870 875 880Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys
Lys Leu Asp Phe Lys 885 890 895Val Ser Ser Thr Ser Asn Asn Leu Ile
Ser Thr Ile Pro Ser Asp Asn 900 905 910Leu Ala Ala Gly Thr Asp Asn
Thr Ser Ser Leu Gly Pro Pro Ser Met 915 920 925Pro Val His Tyr Asp
Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 930 935 940Ser Ser Pro
Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu945 950 955
960Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu
965 970 975Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg
Leu Phe 980 985 990Lys Gly Lys Arg Ala His Gly Pro Ala Leu Leu Thr
Lys Asp Asn Ala 995 1000 1005Leu Phe Lys Val Ser Ile Ser Leu Leu
Lys Thr Asn Lys Thr Ser 1010 1015 1020Asn Asn Ser Ala Thr Asn Arg
Lys Thr His Ile Asp Gly Pro Ser 1025 1030 1035Leu Leu Ile Glu Asn
Ser Pro Ser Val Trp Gln Asn Ile Leu Glu 1040 1045 1050Ser Asp Thr
Glu Phe Lys Lys Val Thr Pro Leu Ile His Asp Arg 1055 1060 1065Met
Leu Met Asp Lys Asn Ala Thr Ala Leu Arg Leu Asn His Met 1070 1075
1080Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met Val Gln Gln
1085 1090 1095Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro
Asp Met 1100 1105 1110Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser
Ala Arg Trp Ile 1115 1120 1125Gln Arg Thr His Gly Lys Asn Ser Leu
Asn Ser Gly Gln Gly Pro 1130 1135 1140Ser Pro Lys Gln Leu Val Ser
Leu Gly Pro Glu Lys Ser Val Glu 1145 1150 1155Gly Gln Asn Phe Leu
Ser Glu Lys Asn Lys Val Val Val Gly Lys 1160 1165 1170Gly Glu Phe
Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro 1175 1180 1185Ser
Ser Arg Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu 1190 1195
1200Asn Asn Thr His Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu
1205 1210 1215Lys Lys Glu Thr Leu Ile Gln Glu Asn Val Val Leu Pro
Gln Ile 1220 1225 1230His Thr Val Thr Gly Thr Lys Asn Phe Met Lys
Asn Leu Phe Leu 1235 1240 1245Leu Ser Thr Arg Gln Asn Val Glu Gly
Ser Tyr Glu Gly Ala Tyr 1250 1255 1260Ala Pro Val Leu Gln Asp Phe
Arg Ser Leu Asn Asp Ser Thr Asn 1265 1270 1275Arg Thr Lys Lys His
Thr Ala His Phe Ser Lys Lys Gly Glu Glu 1280 1285 1290Glu Asn Leu
Glu Gly Leu Gly Asn Gln Thr Lys Gln Ile Val Glu 1295 1300 1305Lys
Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn Thr Ser Gln Gln 1310 1315
1320Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys Gln Phe Arg
1325 1330 1335Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile
Val Asp 1340 1345 1350Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys
His Leu Thr Pro 1355 1360 1365Ser Thr Leu Thr Gln Ile Asp Tyr Asn
Glu Lys Glu Lys Gly Ala 1370 1375 1380Ile Thr Gln Ser Pro Leu Ser
Asp Cys Leu Thr Arg Ser His Ser 1385 1390 1395Ile Pro Gln Ala Asn
Arg Ser Pro Leu Pro Ile Ala Lys Val Ser 1400 1405 1410Ser Phe Pro
Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe 1415 1420 1425Gln
Asp Asn Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys 1430 1435
1440Asp Ser Gly Val Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys
1445 1450 1455Lys Asn Asn Leu Ser Leu Ala Ile Leu Thr Leu Glu Met
Thr Gly 1460 1465 1470Asp Gln Arg Glu Val Gly Ser Leu Gly Thr Ser
Ala Thr Asn Ser 1475 1480 1485Val Thr Tyr Lys Lys Val Glu Asn Thr
Val Leu Pro Lys Pro Asp 1490 1495 1500Leu Pro Lys Thr Ser Gly Lys
Val Glu Leu Leu Pro Lys Val His 1505 1510 1515Ile Tyr Gln Lys Asp
Leu Phe Pro Thr Glu Thr Ser Asn Gly Ser 1520 1525 1530Pro Gly His
Leu Asp Leu Val Glu Gly Ser Leu Leu Gln Gly Thr 1535 1540 1545Glu
Gly Ala Ile Lys Trp Asn Glu Ala Asn Arg Pro Gly Lys Val 1550 1555
1560Pro Phe Leu Arg Val Ala Thr Glu Ser Ser Ala Lys Thr Pro Ser
1565 1570 1575Lys Leu Leu Asp Pro Leu Ala Trp Asp Asn His Tyr Gly
Thr Gln 1580 1585 1590Ile Pro Lys Glu Glu Trp Lys Ser Gln Glu Lys
Ser Pro Glu Lys 1595 1600 1605Thr Ala Phe Lys Lys Lys Asp Thr Ile
Leu Ser Leu Asn Ala Cys 1610 1615 1620Glu Ser Asn His Ala Ile Ala
Ala Ile Asn Glu Gly Gln Asn Lys 1625 1630 1635Pro Glu Ile Glu Val
Thr Trp Ala Lys Gln Gly Arg Thr Glu Arg 1640 1645 1650Leu Cys Ser
Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu 1655 1660 1665Ile
Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr 1670 1675
1680Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile
1685 1690 1695Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln
Lys Lys 1700 1705 1710Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg
Leu Trp Asp Tyr 1715 1720 1725Gly Met Ser Ser Ser Pro His Val Leu
Arg Asn Arg Ala Gln Ser 1730 1735 1740Gly Ser Val Pro Gln Phe Lys
Lys Val Val Phe Gln Glu Phe Thr 1745 1750 1755Asp Gly Ser Phe Thr
Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu 1760 1765 1770His Leu Gly
Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp 1775 1780 1785Asn
Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser 1790 1795
1800Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly
1805 1810 1815Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr
Lys Thr 1820 1825 1830Tyr Phe Trp Lys Val Gln His His Met Ala Pro
Thr Lys Asp Glu 1835 1840 1845Phe Asp Cys Lys Ala Trp Ala Tyr Phe
Ser Asp Val Asp Leu Glu 1850 1855 1860Lys Asp Val His Ser Gly Leu
Ile Gly Pro Leu Leu Val Cys His 1865 1870 1875Thr Asn Thr Leu Asn
Pro Ala His Gly Arg Gln Val Thr Val Gln 1880 1885 1890Glu Phe Ala
Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp 1895 1900 1905Tyr
Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn 1910 1915
1920Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His
1925 1930 1935Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu
Val Met 1940 1945 1950Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu
Ser Met Gly Ser 1955 1960 1965Asn Glu Asn Ile His Ser Ile His Phe
Ser Gly His Val Phe Thr 1970 1975 1980Val Arg Lys Lys Glu Glu Tyr
Lys Met Ala Leu Tyr Asn Leu Tyr 1985 1990 1995Pro Gly Val Phe Glu
Thr Val Glu Met Leu Pro Ser Lys Ala Gly 2000 2005 2010Ile Trp Arg
Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly 2015 2020 2025Met
Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro 2030 2035
2040Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala
2045 2050 2055Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg
Leu His 2060 2065 2070Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys
Glu Pro Phe Ser 2075 2080 2085Trp Ile Lys Val Asp Leu Leu Ala Pro
Met Ile Ile His Gly Ile 2090 2095 2100Lys Thr Gln Gly Ala Arg Gln
Lys Phe Ser Ser Leu Tyr Ile Ser 2105 2110 2115Gln Phe Ile Ile Met
Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr 2120 2125 2130Tyr Arg Gly
Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn 2135 2140 2145Val
Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile 2150 2155
2160Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg
2165 2170 2175Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn
Ser Cys 2180 2185 2190Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile
Ser Asp Ala Gln 2195 2200 2205Ile Thr Ala Ser Ser Tyr Phe Thr Asn
Met Phe Ala Thr Trp Ser 2210 2215 2220Pro Ser Lys Ala Arg Leu His
Leu Gln Gly Arg Ser Asn Ala Trp 2225 2230 2235Arg Pro Gln Val Asn
Asn Pro Lys Glu Trp Leu Gln Val Asp Phe 2240 2245 2250Gln Lys Thr
Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys 2255 2260 2265Ser
Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser 2270 2275
2280Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys
2285 2290 2295Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro
Val Val 2300 2305 2310Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr
Leu Arg Ile His 2315 2320 2325Pro Gln Ser Trp Val His Gln Ile Ala
Leu Arg Met Glu Val Leu 2330 2335 2340Gly Cys Glu Ala Gln Asp Leu
Tyr 2345 235022332PRTHomo Sapiens 2Ala Thr Arg Arg Tyr Tyr Leu Gly
Ala Val Glu Leu Ser Trp Asp Tyr1 5 10 15Met Gln Ser Asp Leu Gly Glu
Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25 30Arg Val Pro Lys Ser Phe
Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 35 40 45Thr Leu Phe Val Glu
Phe Thr Val His Leu Phe Asn Ile Ala Lys Pro 50 55 60Arg Pro Pro Trp
Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val65 70 75 80Tyr Asp
Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 85 90
95Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala
100 105 110Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp
Lys Val 115 120 125Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val
Leu Lys Glu Asn 130 135 140Gly Pro Met Ala Ser Asp Pro Leu Cys Leu
Thr Tyr Ser Tyr Leu Ser145 150 155 160His Val Asp Leu Val Lys Asp
Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170 175Leu Val Cys Arg Glu
Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 180 185 190His Lys Phe
Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 195 200 205His
Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 210 215
220Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn
Arg225 230 235 240Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser
Val Tyr Trp His 245 250 255Val Ile Gly Met Gly Thr Thr Pro Glu Val
His Ser Ile Phe Leu Glu 260 265 270Gly His Thr Phe Leu Val Arg Asn
His Arg Gln Ala Ser Leu Glu Ile 275 280 285Ser Pro Ile Thr Phe Leu
Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295 300Gln Phe Leu Leu
Phe Cys His Ile Ser Ser His Gln His Asp Gly Met305 310 315 320Glu
Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 325 330
335Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp
340 345 350Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro
Ser Phe 355 360 365Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys
Thr Trp Val His 370 375 380Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp
Tyr Ala Pro Leu Val Leu385 390 395 400Ala Pro Asp Asp Arg Ser Tyr
Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410 415Gln Arg Ile Gly Arg
Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 420 425 430Asp Glu Thr
Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 435 440 445Leu
Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 450 455
460Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly
Ile465 470 475 480Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro
Lys Gly Val Lys 485 490 495His Leu Lys Asp Phe Pro Ile Leu Pro Gly
Glu Ile Phe Lys Tyr Lys 500 505 510Trp Thr Val Thr Val Glu Asp Gly
Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525Leu Thr Arg Tyr Tyr Ser
Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535 540Ser Gly Leu Ile
Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp545 550 555 560Gln
Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 565 570
575Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln
580 585 590Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro
Glu Phe 595 600 605Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr
Val Phe Asp Ser 610 615 620Leu Gln Leu Ser Val Cys Leu His Glu Val
Ala Tyr Trp Tyr Ile Leu625 630 635 640Ser Ile Gly Ala Gln Thr Asp
Phe Leu Ser Val Phe Phe Ser Gly Tyr 645 650 655Thr Phe Lys His Lys
Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 660 665 670Phe Ser Gly
Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 675 680 685Ile
Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 690 695
700Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr
Glu705 710 715 720Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser
Lys Asn Asn Ala 725 730 735Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser
Arg His Pro Ser Thr Arg 740 745 750Gln Lys Gln Phe Asn Ala Thr Thr
Ile Pro Glu Asn Asp Ile Glu Lys 755 760 765Thr Asp Pro Trp Phe Ala
His Arg Thr Pro Met Pro Lys Ile Gln Asn 770 775 780Val Ser Ser Ser
Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro785 790 795 800His
Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 805 810
815Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser
820 825 830Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp
Met Val 835 840 845Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn
Glu Lys Leu Gly 850 855 860Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu
Asp Phe Lys Val Ser Ser865 870 875 880Thr Ser Asn Asn Leu Ile Ser
Thr Ile Pro Ser Asp Asn Leu Ala Ala 885 890 895Gly Thr Asp Asn Thr
Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 900 905 910Tyr Asp Ser
Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 915 920 925Leu
Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 930 935
940Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser
Trp945 950 955 960Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu
Phe Lys Gly Lys 965 970 975Arg Ala His Gly Pro Ala Leu Leu Thr Lys
Asp Asn Ala Leu Phe Lys 980 985 990Val Ser Ile Ser Leu Leu Lys Thr
Asn Lys Thr Ser Asn Asn Ser Ala 995 1000 1005Thr Asn Arg Lys Thr
His Ile Asp Gly Pro Ser Leu Leu Ile Glu 1010 1015 1020Asn Ser Pro
Ser Val Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu 1025 1030 1035Phe
Lys Lys Val Thr Pro Leu Ile His Asp Arg Met Leu Met Asp 1040 1045
1050Lys Asn Ala Thr Ala Leu Arg Leu Asn His Met Ser Asn Lys Thr
1055 1060 1065Thr Ser Ser Lys Asn Met Glu Met Val Gln Gln Lys Lys
Glu Gly 1070 1075 1080Pro Ile Pro Pro Asp Ala Gln Asn Pro Asp Met
Ser Phe Phe Lys 1085 1090 1095Met Leu Phe Leu Pro Glu Ser Ala Arg
Trp Ile Gln Arg Thr His 1100 1105 1110Gly Lys Asn Ser Leu Asn Ser
Gly Gln Gly Pro Ser Pro Lys Gln 1115 1120 1125Leu Val Ser Leu Gly
Pro Glu Lys Ser Val Glu Gly Gln Asn Phe 1130 1135 1140Leu Ser Glu
Lys Asn Lys Val Val Val Gly Lys Gly Glu Phe Thr 1145 1150 1155Lys
Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg Asn 1160 1165
1170Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His
1175 1180 1185Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys
Glu Thr 1190 1195 1200Leu Ile Gln Glu Asn Val Val Leu Pro Gln Ile
His Thr Val Thr 1205 1210 1215Gly Thr Lys Asn Phe Met Lys Asn Leu
Phe Leu Leu Ser Thr Arg 1220 1225 1230Gln Asn Val Glu Gly Ser Tyr
Glu Gly Ala Tyr Ala Pro Val Leu 1235 1240 1245Gln Asp Phe Arg Ser
Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys 1250 1255 1260His Thr Ala
His Phe Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu 1265 1270 1275Gly
Leu Gly Asn Gln Thr Lys Gln Ile Val Glu Lys Tyr Ala Cys 1280 1285
1290Thr Thr Arg Ile Ser Pro Asn Thr Ser Gln Gln Asn Phe Val Thr
1295 1300 1305Gln Arg Ser Lys Arg Ala Leu Lys Gln Phe Arg Leu Pro
Leu Glu 1310 1315 1320Glu Thr Glu Leu Glu Lys Arg Ile Ile Val Asp
Asp Thr Ser Thr 1325 1330 1335Gln Trp Ser Lys Asn Met Lys His Leu
Thr Pro Ser Thr Leu Thr 1340 1345 1350Gln Ile Asp Tyr Asn Glu Lys
Glu Lys Gly Ala Ile Thr Gln Ser 1355 1360 1365Pro Leu Ser Asp Cys
Leu Thr Arg Ser His Ser Ile Pro Gln Ala 1370 1375 1380Asn Arg Ser
Pro Leu Pro Ile Ala Lys Val Ser Ser Phe Pro Ser 1385 1390 1395Ile
Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn Ser 1400 1405
1410Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val
1415 1420 1425Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn
Asn Leu 1430 1435 1440Ser Leu Ala Ile Leu Thr Leu Glu Met Thr Gly
Asp Gln Arg Glu 1445 1450 1455Val Gly Ser Leu Gly Thr Ser Ala Thr
Asn Ser Val Thr Tyr Lys 1460 1465 1470Lys Val Glu Asn Thr Val Leu
Pro Lys Pro Asp Leu Pro Lys Thr 1475 1480 1485Ser Gly Lys Val Glu
Leu Leu Pro Lys Val His Ile Tyr Gln Lys 1490 1495 1500Asp Leu Phe
Pro Thr Glu Thr Ser Asn Gly Ser Pro Gly His Leu 1505 1510 1515Asp
Leu Val Glu Gly Ser Leu Leu Gln Gly Thr Glu Gly Ala Ile 1520 1525
1530Lys Trp Asn Glu Ala Asn Arg Pro Gly Lys Val Pro Phe Leu Arg
1535 1540 1545Val Ala Thr Glu Ser Ser Ala Lys Thr Pro Ser Lys Leu
Leu Asp 1550 1555 1560Pro Leu Ala Trp Asp Asn His Tyr Gly Thr Gln
Ile Pro Lys Glu 1565 1570 1575Glu Trp Lys Ser Gln Glu Lys Ser Pro
Glu Lys Thr Ala Phe Lys 1580 1585 1590Lys Lys Asp Thr Ile Leu Ser
Leu Asn Ala Cys Glu Ser Asn His 1595 1600 1605Ala Ile Ala Ala Ile
Asn Glu Gly Gln Asn Lys Pro Glu Ile Glu 1610 1615 1620Val Thr Trp
Ala Lys Gln Gly Arg Thr Glu Arg Leu Cys Ser Gln 1625 1630 1635Asn
Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 1640 1645
1650Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile
1655 1660 1665Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp
Glu Asp 1670 1675 1680Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys
Thr Arg His Tyr 1685 1690 1695Phe Ile Ala Ala Val Glu Arg Leu Trp
Asp Tyr Gly Met Ser Ser 1700 1705 1710Ser Pro His Val Leu Arg Asn
Arg Ala Gln Ser Gly Ser Val Pro 1715 1720 1725Gln Phe Lys Lys Val
Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 1730 1735 1740Thr Gln Pro
Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 1745 1750 1755Leu
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val 1760 1765
1770Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser
1775 1780 1785Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu
Pro Arg 1790 1795 1800Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr
Tyr Phe Trp Lys 1805 1810 1815Val Gln His His Met Ala Pro Thr Lys
Asp Glu Phe Asp Cys Lys 1820 1825 1830Ala Trp Ala Tyr Phe Ser Asp
Val Asp Leu Glu Lys Asp Val His 1835 1840 1845Ser Gly Leu Ile Gly
Pro Leu Leu Val Cys His Thr Asn Thr Leu 1850 1855 1860Asn Pro Ala
His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu 1865 1870 1875Phe
Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu 1880 1885
1890Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu
1895 1900 1905Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile
Asn Gly 1910 1915 1920Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met
Ala Gln Asp Gln 1925 1930 1935Arg Ile Arg Trp Tyr Leu Leu Ser Met
Gly Ser Asn Glu Asn Ile 1940 1945 1950His Ser Ile His Phe Ser Gly
His Val Phe Thr Val Arg Lys Lys 1955 1960 1965Glu Glu Tyr Lys Met
Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 1970 1975 1980Glu Thr Val
Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val 1985 1990 1995Glu
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu 2000 2005
2010Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala
2015 2020 2025Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly
Gln Tyr 2030 2035 2040Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His
Tyr Ser Gly Ser 2045 2050 2055Ile Asn Ala Trp Ser Thr Lys Glu Pro
Phe Ser Trp Ile Lys Val 2060 2065 2070Asp Leu Leu Ala Pro Met Ile
Ile His Gly Ile Lys Thr Gln Gly 2075 2080 2085Ala Arg Gln Lys Phe
Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile 2090 2095 2100Met Tyr Ser
Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn 2105 2110 2115Ser
Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser 2120 2125
2130Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr
2135 2140 2145Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr
Leu Arg 2150 2155 2160Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys
Ser Met Pro Leu 2165 2170 2175Gly Met Glu Ser Lys Ala Ile Ser Asp
Ala Gln Ile Thr Ala Ser 2180 2185 2190Ser Tyr Phe Thr Asn Met Phe
Ala Thr Trp Ser Pro Ser Lys Ala 2195 2200 2205Arg Leu His Leu Gln
Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 2210 2215 2220Asn Asn Pro
Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met 2225 2230 2235Lys
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr 2240 2245
2250Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly
2255 2260 2265His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys
Val Phe 2270 2275 2280Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val
Asn Ser Leu Asp 2285 2290 2295Pro Pro Leu Leu Thr Arg Tyr Leu Arg
Ile His Pro Gln Ser Trp 2300 2305 2310Val His Gln Ile Ala Leu Arg
Met Glu Val Leu Gly Cys Glu Ala 2315 2320 2325Gln Asp Leu Tyr
233031457PRTArtificial SequenceSynthetic Sequence 3Met Gln Ile Glu
Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe1 5 10 15Cys Phe Ser
Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 20 25 30Trp Asp
Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 35 40 45Phe
Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 50 55
60Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Val His Leu Phe Asn Ile65
70 75 80Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile
Gln 85 90 95Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met
Ala Ser 100 105 110His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr
Trp Lys Ala Ser 115 120 125Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser
Gln Arg Glu Lys Glu Asp 130 135 140Asp Lys Val Phe Pro Gly Gly Ser
His Thr Tyr Val Trp Gln Val Leu145 150 155 160Lys Glu Asn Gly Pro
Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 165 170 175Tyr Leu Ser
His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 180 185 190Gly
Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 195 200
205Gln Thr Leu His
Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 210 215 220Lys Ser
Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp225 230 235
240Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr
245 250 255Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys
Ser Val 260 265 270Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu
Val His Ser Ile 275 280 285Phe Leu Glu Gly His Thr Phe Leu Val Arg
Asn His Arg Gln Ala Ser 290 295 300Leu Glu Ile Ser Pro Ile Thr Phe
Leu Thr Ala Gln Thr Leu Leu Met305 310 315 320Asp Leu Gly Gln Phe
Leu Leu Phe Cys His Ile Ser Ser His Gln His 325 330 335Asp Gly Met
Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 340 345 350Gln
Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 355 360
365Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser
370 375 380Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro
Lys Thr385 390 395 400Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp
Trp Asp Tyr Ala Pro 405 410 415Leu Val Leu Ala Pro Asp Asp Arg Ser
Tyr Lys Ser Gln Tyr Leu Asn 420 425 430Asn Gly Pro Gln Arg Ile Gly
Arg Lys Tyr Lys Lys Val Arg Phe Met 435 440 445Ala Tyr Thr Asp Glu
Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 450 455 460Ser Gly Ile
Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu465 470 475
480Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro
485 490 495His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu
Pro Lys 500 505 510Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro
Gly Glu Ile Phe 515 520 525Lys Tyr Lys Trp Thr Val Thr Val Glu Asp
Gly Pro Thr Lys Ser Asp 530 535 540Pro Arg Cys Leu Thr Arg Tyr Tyr
Ser Ser Phe Val Asn Met Glu Arg545 550 555 560Asp Leu Ala Ser Gly
Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 565 570 575Ser Val Asp
Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 580 585 590Ile
Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 595 600
605Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp
610 615 620Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly
Tyr Val625 630 635 640Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His
Glu Val Ala Tyr Trp 645 650 655Tyr Ile Leu Ser Ile Gly Ala Gln Thr
Asp Phe Leu Ser Val Phe Phe 660 665 670Ser Gly Tyr Thr Phe Lys His
Lys Met Val Tyr Glu Asp Thr Leu Thr 675 680 685Leu Phe Pro Phe Ser
Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 690 695 700Gly Leu Trp
Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly705 710 715
720Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp
725 730 735Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu
Ser Lys 740 745 750Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn
Pro Pro Val Leu 755 760 765Lys Arg His Gln Arg Glu Ile Thr Arg Thr
Thr Leu Gln Ser Asp Gln 770 775 780Glu Glu Ile Asp Tyr Asp Asp Thr
Ile Ser Val Glu Met Lys Lys Glu785 790 795 800Asp Phe Asp Ile Tyr
Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 805 810 815Gln Lys Lys
Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 820 825 830Asp
Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 835 840
845Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr
850 855 860Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn
Glu His865 870 875 880Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu
Val Glu Asp Asn Ile 885 890 895Met Val Thr Phe Arg Asn Gln Ala Ser
Arg Pro Tyr Ser Phe Tyr Ser 900 905 910Ser Leu Ile Ser Tyr Glu Glu
Asp Gln Arg Gln Gly Ala Glu Pro Arg 915 920 925Lys Asn Phe Val Lys
Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 930 935 940Gln His His
Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp945 950 955
960Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu
965 970 975Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro
Ala His 980 985 990Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe
Phe Thr Ile Phe 995 1000 1005Asp Glu Thr Lys Ser Trp Tyr Phe Thr
Glu Asn Met Glu Arg Asn 1010 1015 1020Cys Arg Ala Pro Cys Asn Ile
Gln Met Glu Asp Pro Thr Phe Lys 1025 1030 1035Glu Asn Tyr Arg Phe
His Ala Ile Asn Gly Tyr Ile Met Asp Thr 1040 1045 1050Leu Pro Gly
Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr 1055 1060 1065Leu
Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe 1070 1075
1080Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met
1085 1090 1095Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val
Glu Met 1100 1105 1110Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu
Cys Leu Ile Gly 1115 1120 1125Glu His Leu His Ala Gly Met Ser Thr
Leu Phe Leu Val Tyr Ser 1130 1135 1140Asn Lys Cys Gln Thr Pro Leu
Gly Met Ala Ser Gly His Ile Arg 1145 1150 1155Asp Phe Gln Ile Thr
Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro 1160 1165 1170Lys Leu Ala
Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 1175 1180 1185Thr
Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro 1190 1195
1200Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe
1205 1210 1215Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser
Leu Asp 1220 1225 1230Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser
Thr Gly Thr Leu 1235 1240 1245Met Val Phe Phe Gly Asn Val Asp Ser
Ser Gly Ile Lys His Asn 1250 1255 1260Ile Phe Asn Pro Pro Ile Ile
Ala Arg Tyr Ile Arg Leu His Pro 1265 1270 1275Thr His Tyr Ser Ile
Arg Ser Thr Leu Arg Met Glu Leu Met Gly 1280 1285 1290Cys Asp Leu
Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys 1295 1300 1305Ala
Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn 1310 1315
1320Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln
1325 1330 1335Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro
Lys Glu 1340 1345 1350Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys
Val Thr Gly Val 1355 1360 1365Thr Thr Gln Gly Val Lys Ser Leu Leu
Thr Ser Met Tyr Val Lys 1370 1375 1380Glu Phe Leu Ile Ser Ser Ser
Gln Asp Gly His Gln Trp Thr Leu 1385 1390 1395Phe Phe Gln Asn Gly
Lys Val Lys Val Phe Gln Gly Asn Gln Asp 1400 1405 1410Ser Phe Thr
Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 1415 1420 1425Arg
Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala 1430 1435
1440Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 1445
1450 145541438PRTArtificial SequenceBDD Factor VIII 4Ala Thr Arg
Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1 5 10 15Met Gln
Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25 30Arg
Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 35 40
45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro
50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu
Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser
His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala
Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu
Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser His Thr Tyr
Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met Ala Ser Asp
Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155 160His Val Asp
Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170 175Leu
Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 180 185
190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp
195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala
Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly
Tyr Val Asn Arg225 230 235 240Ser Leu Pro Gly Leu Ile Gly Cys His
Arg Lys Ser Val Tyr Trp His 245 250 255Val Ile Gly Met Gly Thr Thr
Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270Gly His Thr Phe Leu
Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285Ser Pro Ile
Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295 300Gln
Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met305 310
315 320Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu
Arg 325 330 335Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp
Leu Thr Asp 340 345 350Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp
Asn Ser Pro Ser Phe 355 360 365Ile Gln Ile Arg Ser Val Ala Lys Lys
His Pro Lys Thr Trp Val His 370 375 380Tyr Ile Ala Ala Glu Glu Glu
Asp Trp Asp Tyr Ala Pro Leu Val Leu385 390 395 400Ala Pro Asp Asp
Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410 415Gln Arg
Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 420 425
430Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile
435 440 445Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu
Ile Ile 450 455 460Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr
Pro His Gly Ile465 470 475 480Thr Asp Val Arg Pro Leu Tyr Ser Arg
Arg Leu Pro Lys Gly Val Lys 485 490 495His Leu Lys Asp Phe Pro Ile
Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510Trp Thr Val Thr Val
Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525Leu Thr Arg
Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535 540Ser
Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp545 550
555 560Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu
Phe 565 570 575Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu
Asn Ile Gln 580 585 590Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu
Glu Asp Pro Glu Phe 595 600 605Gln Ala Ser Asn Ile Met His Ser Ile
Asn Gly Tyr Val Phe Asp Ser 610 615 620Leu Gln Leu Ser Val Cys Leu
His Glu Val Ala Tyr Trp Tyr Ile Leu625 630 635 640Ser Ile Gly Ala
Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 645 650 655Thr Phe
Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 660 665
670Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp
675 680 685Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met
Thr Ala 690 695 700Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly
Asp Tyr Tyr Glu705 710 715 720Asp Ser Tyr Glu Asp Ile Ser Ala Tyr
Leu Leu Ser Lys Asn Asn Ala 725 730 735Ile Glu Pro Arg Ser Phe Ser
Gln Asn Pro Pro Val Leu Lys Arg His 740 745 750Gln Arg Glu Ile Thr
Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 755 760 765Asp Tyr Asp
Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 770 775 780Ile
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys785 790
795 800Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr
Gly 805 810 815Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln
Ser Gly Ser 820 825 830Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu
Phe Thr Asp Gly Ser 835 840 845Phe Thr Gln Pro Leu Tyr Arg Gly Glu
Leu Asn Glu His Leu Gly Leu 850 855 860Leu Gly Pro Tyr Ile Arg Ala
Glu Val Glu Asp Asn Ile Met Val Thr865 870 875 880Phe Arg Asn Gln
Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 885 890 895Ser Tyr
Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 900 905
910Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His
915 920 925Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala
Tyr Phe 930 935 940Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly
Leu Ile Gly Pro945 950 955 960Leu Leu Val Cys His Thr Asn Thr Leu
Asn Pro Ala His Gly Arg Gln 965 970 975Val Thr Val Gln Glu Phe Ala
Leu Phe Phe Thr Ile Phe Asp Glu Thr 980 985 990Lys Ser Trp Tyr Phe
Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro 995 1000 1005Cys Asn
Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg 1010 1015
1020Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu
1025 1030 1035Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu
Ser Met 1040 1045 1050Gly Ser Asn Glu Asn Ile His Ser Ile His Phe
Ser Gly His Val 1055 1060 1065Phe Thr Val Arg Lys Lys Glu Glu Tyr
Lys Met Ala Leu Tyr Asn 1070 1075 1080Leu Tyr Pro Gly Val Phe Glu
Thr Val Glu Met Leu Pro Ser Lys 1085 1090 1095Ala Gly Ile Trp Arg
Val Glu Cys Leu Ile Gly Glu His Leu His 1100 1105 1110Ala Gly Met
Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln 1115 1120 1125Thr
Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile 1130 1135
1140Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg
1145 1150 1155Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys
Glu Pro 1160 1165 1170Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro
Met Ile Ile His 1175 1180 1185Gly Ile Lys Thr Gln Gly Ala Arg Gln
Lys Phe Ser Ser Leu Tyr 1190 1195 1200Ile Ser Gln Phe Ile Ile Met
Tyr Ser Leu Asp
Gly Lys Lys Trp 1205 1210 1215Gln Thr Tyr Arg Gly Asn Ser Thr Gly
Thr Leu Met Val Phe Phe 1220 1225 1230Gly Asn Val Asp Ser Ser Gly
Ile Lys His Asn Ile Phe Asn Pro 1235 1240 1245Pro Ile Ile Ala Arg
Tyr Ile Arg Leu His Pro Thr His Tyr Ser 1250 1255 1260Ile Arg Ser
Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn 1265 1270 1275Ser
Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp 1280 1285
1290Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr
1295 1300 1305Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg
Ser Asn 1310 1315 1320Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu
Trp Leu Gln Val 1325 1330 1335Asp Phe Gln Lys Thr Met Lys Val Thr
Gly Val Thr Thr Gln Gly 1340 1345 1350Val Lys Ser Leu Leu Thr Ser
Met Tyr Val Lys Glu Phe Leu Ile 1355 1360 1365Ser Ser Ser Gln Asp
Gly His Gln Trp Thr Leu Phe Phe Gln Asn 1370 1375 1380Gly Lys Val
Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro 1385 1390 1395Val
Val Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg 1400 1405
1410Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu
1415 1420 1425Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 1430
1435572PRTArtificial SequenceExtracellular Region of GPA 5Leu Ser
Thr Thr Glu Val Ala Met His Thr Ser Thr Ser Ser Ser Val1 5 10 15Thr
Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His Lys Arg Asp 20 25
30Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu Ile Ser Val
35 40 45Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg Val Gln
Leu 50 55 60Ala His His Phe Ser Glu Pro Glu65 706484PRTArtificial
SequenceSynthetic Sequence 6Met Glu Trp Ser Trp Val Phe Leu Phe Phe
Leu Ser Val Thr Thr Gly1 5 10 15Val His Ser Arg Val Gln Leu Gln Gln
Ser Gly Ala Glu Leu Ala Arg 20 25 30Pro Gly Ala Ser Val Lys Met Ser
Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45Thr Thr Tyr Thr Ile His Trp
Val Lys Gln Lys Thr Gly Gln Gly Leu 50 55 60Glu Trp Ile Gly Tyr Ile
Asn Pro Ser Ser Asp Tyr Thr Arg Tyr Asn65 70 75 80Pro Lys Phe Lys
Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 85 90 95Thr Ala Tyr
Met Lys Leu Asn Ser Leu Ala Ser Asp Asp Ser Ala Val 100 105 110Tyr
Tyr Cys Gln Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr 115 120
125Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
130 135 140Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Pro Ile
Met Ser145 150 155 160Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys
Ser Ala Ala Ser Ser 165 170 175Val Ser Tyr Ile Tyr Trp Phe Gln Gln
Lys Pro Gly Thr Ser Pro Lys 180 185 190Leu Trp Ile Tyr Ser Thr Ser
Thr Leu Pro Ser Gly Val Pro Thr Arg 195 200 205Phe Ser Gly Ser Gly
Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 210 215 220Met Glu Ala
Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser225 230 235
240Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Arg Gly Gly
245 250 255Gly Gly Ala Gly Gly Gly Gly Cys Lys Pro Cys Ile Cys Thr
Val Pro 260 265 270Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro
Lys Asp Val Leu 275 280 285Thr Ile Thr Leu Thr Pro Lys Val Thr Cys
Val Val Val Asp Ile Ser 290 295 300Lys Asp Asp Pro Glu Val Gln Phe
Ser Trp Phe Val Asp Asp Val Glu305 310 315 320Val His Thr Ala Gln
Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 325 330 335Phe Arg Ser
Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 340 345 350Gly
Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 355 360
365Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln
370 375 380Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp
Lys Val385 390 395 400Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro
Glu Asp Ile Thr Val 405 410 415Glu Trp Gln Trp Asn Gly Gln Pro Ala
Glu Asn Tyr Lys Asn Thr Gln 420 425 430Pro Ile Met Asp Thr Asp Gly
Ser Tyr Phe Val Tyr Ser Lys Leu Asn 435 440 445Val Gln Lys Ser Asn
Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 450 455 460Leu His Glu
Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His465 470 475
480Ser Pro Gly Lys7484PRTArtificial SequenceSynthetic Sequence 7Met
Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly1 5 10
15Val His Ser Arg Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg
20 25 30Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr
Phe 35 40 45Thr Asn Tyr Ala Met His Trp Val Lys Gln Arg Pro Gly Gln
Gly Leu 50 55 60Glu Trp Ile Gly Tyr Ile Asn Pro Lys Ser Asp Asn Thr
Asn Tyr Asn65 70 75 80Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr
Asp Lys Ser Ser Ala 85 90 95Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr
Ser Asp Asp Ser Ala Val 100 105 110Tyr Tyr Cys Gln Thr Gly Thr Arg
Asp Tyr Trp Gly Gln Gly Thr Thr 115 120 125Leu Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 130 135 140Gly Gly Gly Ser
His Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser145 150 155 160Ala
Ser Pro Gly Glu Lys Val Thr Ile Phe Cys Ser Ala Ser Ser Ser 165 170
175Ile Thr Tyr Val Tyr Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys
180 185 190Leu Trp Ile Tyr Ser Thr Ser Ser Leu Pro Ser Gly Val Pro
Ala Arg 195 200 205Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu
Thr Ile Ser Arg 210 215 220Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr
Cys His Gln Arg Asn Ser225 230 235 240Tyr Pro Phe Thr Phe Gly Ser
Gly Thr Lys Leu Glu Ile Lys Gly Gly 245 250 255Gly Gly Ala Gly Gly
Gly Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 260 265 270Glu Val Ser
Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 275 280 285Thr
Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 290 295
300Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val
Glu305 310 315 320Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln
Phe Asn Ser Thr 325 330 335Phe Arg Ser Val Ser Glu Leu Pro Ile Met
His Gln Asp Trp Leu Asn 340 345 350Gly Lys Glu Phe Lys Cys Arg Val
Asn Ser Ala Ala Phe Pro Ala Pro 355 360 365Ile Glu Lys Thr Ile Ser
Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 370 375 380Val Tyr Thr Ile
Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val385 390 395 400Ser
Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 405 410
415Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln
420 425 430Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys
Leu Asn 435 440 445Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe
Thr Cys Ser Val 450 455 460Leu His Glu Gly Leu His Asn His His Thr
Glu Lys Ser Leu Ser His465 470 475 480Ser Pro Gly
Lys8489PRTArtificial SequenceSynthetic Sequence 8Met Glu Trp Ser
Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly1 5 10 15Val His Ser
Arg Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 20 25 30Pro Gly
Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45Thr
Thr Tyr Thr Ile His Trp Val Lys Gln Lys Thr Gly Gln Gly Leu 50 55
60Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Asp Tyr Thr Arg Tyr Asn65
70 75 80Pro Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser
Ser 85 90 95Thr Ala Tyr Met Lys Leu Asn Ser Leu Ala Ser Asp Asp Ser
Ala Val 100 105 110Tyr Tyr Cys Gln Thr Gly Thr Arg Asp Tyr Trp Gly
Gln Gly Thr Thr 115 120 125Leu Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly 130 135 140Gly Gly Gly Ser Asp Ile Val Leu
Thr Gln Ser Pro Ala Ser Leu Ala145 150 155 160Val Ser Leu Gly Gln
Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser 165 170 175Val Ser Thr
Ser Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro 180 185 190Gly
Gln Pro Pro Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser 195 200
205Gly Val Pro Thr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser
210 215 220Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
Tyr Cys225 230 235 240His Gln Arg Asn Ser Phe Pro Phe Thr Phe Gly
Ser Gly Thr Lys Leu 245 250 255Glu Ile Arg Gly Gly Gly Gly Ala Gly
Gly Gly Gly Cys Lys Pro Cys 260 265 270Ile Cys Thr Val Pro Glu Val
Ser Ser Val Phe Ile Phe Pro Pro Lys 275 280 285Pro Lys Asp Val Leu
Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 290 295 300Val Val Asp
Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe305 310 315
320Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu
325 330 335Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile
Met His 340 345 350Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg
Val Asn Ser Ala 355 360 365Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Thr Lys Gly Arg 370 375 380Pro Lys Ala Pro Gln Val Tyr Thr
Ile Pro Pro Pro Lys Glu Gln Met385 390 395 400Ala Lys Asp Lys Val
Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 405 410 415Glu Asp Ile
Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 420 425 430Tyr
Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 435 440
445Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr
450 455 460Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His
Thr Glu465 470 475 480Lys Ser Leu Ser His Ser Pro Gly Lys
4859484PRTArtificial SequenceSynthetic Sequence 9Met Glu Trp Ser
Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly1 5 10 15Val His Ser
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 20 25 30Pro Gly
Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45Thr
Arg Tyr Ser Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 50 55
60Glu Trp Ile Gly Tyr Ile Asn Pro Gly Thr Tyr Tyr Thr Asn Tyr Asn65
70 75 80Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser
Ser 85 90 95Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser
Ala Val 100 105 110Tyr Tyr Cys Gln Thr Gly Thr Arg Asp Tyr Trp Gly
Gln Gly Thr Thr 115 120 125Leu Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly 130 135 140Gly Gly Gly Ser Gln Ile Val Leu
Thr Gln Ser Pro Pro Ile Met Ser145 150 155 160Ala Ser Pro Gly Glu
Lys Val Thr Ile Thr Cys Ser Ala Ala Ser Ser 165 170 175Val Ser Tyr
Ile Tyr Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys 180 185 190Leu
Trp Ile Tyr Ser Thr Ser Ser Leu Pro Ser Gly Val Pro Thr Arg 195 200
205Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg
210 215 220Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg
Ser Ser225 230 235 240Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu
Glu Ile Arg Gly Gly 245 250 255Gly Gly Ala Gly Gly Gly Gly Cys Lys
Pro Cys Ile Cys Thr Val Pro 260 265 270Glu Val Ser Ser Val Phe Ile
Phe Pro Pro Lys Pro Lys Asp Val Leu 275 280 285Thr Ile Thr Leu Thr
Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 290 295 300Lys Asp Asp
Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu305 310 315
320Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr
325 330 335Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp
Leu Asn 340 345 350Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala
Phe Pro Ala Pro 355 360 365Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly
Arg Pro Lys Ala Pro Gln 370 375 380Val Tyr Thr Ile Pro Pro Pro Lys
Glu Gln Met Ala Lys Asp Lys Val385 390 395 400Ser Leu Thr Cys Met
Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 405 410 415Glu Trp Gln
Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 420 425 430Pro
Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 435 440
445Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val
450 455 460Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu
Ser His465 470 475 480Ser Pro Gly Lys10484PRTArtificial
SequenceSynthetic Sequence 10Met Glu Trp Ser Trp Val Phe Leu Phe
Phe Leu Ser Val Thr Thr Gly1 5 10 15Val His Ser Gln Val Gln Leu Leu
Gln Ser Gly Ala Glu Leu Ala Arg 20 25 30Pro Gly Ala Ser Val Arg Ile
Ser Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45Thr Arg Tyr Ala Met His
Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 50 55 60Glu Trp Ile Gly Tyr
Ile Asn Pro Gly Thr Phe Ser Thr Asn Tyr Asn65 70 75 80Gln Lys Phe
Lys Asp Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 85 90 95Thr Ala
Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 100 105
110Tyr Tyr Cys Gln Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr
115 120 125Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly 130 135 140Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro
Pro Ile Met Ser145 150 155 160Ala Ser Pro Gly Glu Lys Val Thr Ile
Thr Cys Ser Ala Ala Ser Ser 165 170 175Val Ser Tyr Ile Tyr Trp Phe
Gln Gln Lys Pro Gly Thr Ser Pro Lys 180 185 190Leu Trp Ile Tyr Ser
Thr Ser Ser Leu Pro Ser Gly Val Pro Thr Arg 195
200 205Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser
Arg 210 215 220Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln
Arg Ser Ser225 230 235 240Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys
Leu Glu Ile Arg Gly Gly 245 250 255Gly Gly Ala Gly Gly Gly Gly Cys
Lys Pro Cys Ile Cys Thr Val Pro 260 265 270Glu Val Ser Ser Val Phe
Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 275 280 285Thr Ile Thr Leu
Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 290 295 300Lys Asp
Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu305 310 315
320Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr
325 330 335Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp
Leu Asn 340 345 350Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala
Phe Pro Ala Pro 355 360 365Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly
Arg Pro Lys Ala Pro Gln 370 375 380Val Tyr Thr Ile Pro Pro Pro Lys
Glu Gln Met Ala Lys Asp Lys Val385 390 395 400Ser Leu Thr Cys Met
Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 405 410 415Glu Trp Gln
Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 420 425 430Pro
Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 435 440
445Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val
450 455 460Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu
Ser His465 470 475 480Ser Pro Gly Lys11484PRTArtificial
SequenceSynthetic Sequence 11Met Glu Trp Ser Trp Val Phe Leu Phe
Phe Leu Ser Val Thr Thr Gly1 5 10 15Val His Ser Gln Val Gln Leu Gln
Gln Ser Gly Ala Glu Leu Ala Arg 20 25 30Pro Gly Ala Ser Val Lys Met
Ser Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45Thr Ser Tyr Ser Ile His
Trp Ile Lys Gln Arg Pro Gly Gln Ser Leu 50 55 60Glu Trp Ile Gly Tyr
Ile Asn Pro Asn Ser Asp Tyr Ala Asn Tyr Asn65 70 75 80Gln Lys Phe
Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Thr 85 90 95Thr Ala
Tyr Met Gln Leu Ser Ser Leu Thr Thr Asp Asp Ser Ala Val 100 105
110Tyr Tyr Cys Gln Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr
115 120 125Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly 130 135 140Gly Gly Gly Ser His Ile Val Leu Thr Gln Ser Pro
Ala Ile Met Ser145 150 155 160Ala Ser Pro Gly Glu Lys Val Thr Ile
Ile Cys Ser Ala Arg Ser Ser 165 170 175Val Ser Tyr Met Tyr Trp Phe
Gln Gln Lys Pro Gly Thr Ser Pro Lys 180 185 190Leu Trp Ile Tyr Ala
Thr Ser Ser Leu Pro Ser Gly Val Pro Ala Arg 195 200 205Phe Ser Gly
Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 210 215 220Met
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser225 230
235 240Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly
Gly 245 250 255Gly Gly Ala Gly Gly Gly Gly Cys Lys Pro Cys Ile Cys
Thr Val Pro 260 265 270Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys
Pro Lys Asp Val Leu 275 280 285Thr Ile Thr Leu Thr Pro Lys Val Thr
Cys Val Val Val Asp Ile Ser 290 295 300Lys Asp Asp Pro Glu Val Gln
Phe Ser Trp Phe Val Asp Asp Val Glu305 310 315 320Val His Thr Ala
Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 325 330 335Phe Arg
Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 340 345
350Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro
355 360 365Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala
Pro Gln 370 375 380Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala
Lys Asp Lys Val385 390 395 400Ser Leu Thr Cys Met Ile Thr Asp Phe
Phe Pro Glu Asp Ile Thr Val 405 410 415Glu Trp Gln Trp Asn Gly Gln
Pro Ala Glu Asn Tyr Lys Asn Thr Gln 420 425 430Pro Ile Met Asp Thr
Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 435 440 445Val Gln Lys
Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 450 455 460Leu
His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His465 470
475 480Ser Pro Gly Lys12491PRTArtificial SequenceSynthetic Sequence
12Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly1
5 10 15Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala
Arg 20 25 30Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr
Thr Phe 35 40 45Thr Ser Tyr Ser Ile His Trp Ile Lys Gln Arg Pro Gly
Gln Ser Leu 50 55 60Glu Trp Ile Gly Tyr Ile Asn Pro Asn Ser Asp Tyr
Ala Asn Tyr Asn65 70 75 80Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr
Thr Asp Lys Ser Ser Thr 85 90 95Thr Ala Tyr Met Gln Leu Ser Ser Leu
Thr Thr Asp Asp Ser Ala Val 100 105 110Tyr Tyr Cys Gln Thr Gly Thr
Arg Asp Tyr Trp Gly Gln Gly Thr Thr 115 120 125Leu Thr Val Ser Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 130 135 140Gly Gly Gly
Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser145 150 155
160Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser
165 170 175Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr
Gln Gln 180 185 190Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly
Ala Ser Thr Arg 195 200 205Glu Ser Gly Val Pro Asp Arg Phe Thr Gly
Ser Gly Ser Gly Thr Asp 210 215 220Phe Thr Leu Thr Ile Ser Ser Val
Gln Ala Glu Asp Leu Ala Val Tyr225 230 235 240Tyr Cys Gln Asn Asp
His Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 245 250 255Lys Leu Glu
Ile Lys Gly Gly Gly Gly Ala Gly Gly Gly Gly Cys Lys 260 265 270Pro
Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro 275 280
285Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr
290 295 300Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln
Phe Ser305 310 315 320Trp Phe Val Asp Asp Val Glu Val His Thr Ala
Gln Thr Gln Pro Arg 325 330 335Glu Glu Gln Phe Asn Ser Thr Phe Arg
Ser Val Ser Glu Leu Pro Ile 340 345 350Met His Gln Asp Trp Leu Asn
Gly Lys Glu Phe Lys Cys Arg Val Asn 355 360 365Ser Ala Ala Phe Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 370 375 380Gly Arg Pro
Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu385 390 395
400Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe
405 410 415Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln
Pro Ala 420 425 430Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr
Asp Gly Ser Tyr 435 440 445Phe Val Tyr Ser Lys Leu Asn Val Gln Lys
Ser Asn Trp Glu Ala Gly 450 455 460Asn Thr Phe Thr Cys Ser Val Leu
His Glu Gly Leu His Asn His His465 470 475 480Thr Glu Lys Ser Leu
Ser His Ser Pro Gly Lys 485 49013484PRTArtificial SequenceSynthetic
Sequence 13Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr
Thr Gly1 5 10 15Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
Leu Ala Arg 20 25 30Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser
Gly Tyr Thr Phe 35 40 45Thr Arg Tyr Ser Met His Trp Val Lys Gln Arg
Pro Gly Gln Gly Leu 50 55 60Glu Trp Ile Gly Tyr Ile Asn Pro Gly Thr
Tyr Ser Thr Asn Tyr Asn65 70 75 80Gln Lys Phe Lys Asp Arg Ala Thr
Leu Thr Ala Asp Lys Ser Ser Ser 85 90 95Thr Ala Tyr Met Gln Leu Asn
Ser Leu Thr Ser Glu Asp Ser Ala Val 100 105 110Tyr Tyr Cys Gln Thr
Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr 115 120 125Leu Thr Val
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 130 135 140Gly
Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Pro Ile Met Ser145 150
155 160Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ala Ser
Ser 165 170 175Val Ser Tyr Ile Tyr Trp Phe Gln Gln Lys Pro Gly Thr
Ser Pro Lys 180 185 190Leu Trp Ile Tyr Ser Thr Ser Ser Leu Pro Ser
Gly Val Pro Thr Arg 195 200 205Phe Ser Gly Ser Gly Ser Gly Thr Ser
Tyr Ser Leu Thr Ile Ser Arg 210 215 220Met Glu Ala Glu Asp Ala Ala
Thr Tyr Tyr Cys His Gln Arg Ser Ser225 230 235 240Tyr Pro Phe Thr
Phe Gly Ser Gly Thr Lys Leu Glu Ile Arg Gly Gly 245 250 255Gly Gly
Ala Gly Gly Gly Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 260 265
270Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu
275 280 285Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp
Ile Ser 290 295 300Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val
Asp Asp Val Glu305 310 315 320Val His Thr Ala Gln Thr Gln Pro Arg
Glu Glu Gln Phe Asn Ser Thr 325 330 335Phe Arg Ser Val Ser Glu Leu
Pro Ile Met His Gln Asp Trp Leu Asn 340 345 350Gly Lys Glu Phe Lys
Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 355 360 365Ile Glu Lys
Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 370 375 380Val
Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val385 390
395 400Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr
Val 405 410 415Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys
Asn Thr Gln 420 425 430Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val
Tyr Ser Lys Leu Asn 435 440 445Val Gln Lys Ser Asn Trp Glu Ala Gly
Asn Thr Phe Thr Cys Ser Val 450 455 460Leu His Glu Gly Leu His Asn
His His Thr Glu Lys Ser Leu Ser His465 470 475 480Ser Pro Gly
Lys14490PRTArtificial SequenceSynthetic Sequence 14Met Glu Trp Ser
Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly1 5 10 15Val His Ser
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 20 25 30Pro Ser
Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 35 40 45Thr
Arg Phe Gly Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 50 55
60Glu Trp Met Gly Val Ile Trp Gly Asp Gly Ser Thr Asp Tyr His Ser65
70 75 80Ala Leu Ile Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser
Gln 85 90 95Val Phe Phe Arg Leu Asn Ser Leu Gln Ser Asp Asp Ser Ala
Thr Tyr 100 105 110Tyr Cys Ala Arg Ser Phe Gly Met Asp Tyr Trp Gly
Gln Gly Thr Ser 115 120 125Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly 130 135 140Gly Gly Gly Ser Asn Ile Met Met
Thr Gln Ser Pro Ser Ser Leu Ala145 150 155 160Val Ser Ala Gly Glu
Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 165 170 175Ile Leu Asn
Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 180 185 190Lys
Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 195 200
205Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp
210 215 220Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala
Val Tyr225 230 235 240Tyr Cys His Gln Tyr Phe Ser Ser Arg Thr Phe
Gly Gly Gly Thr Lys 245 250 255Leu Glu Ile Lys Gly Gly Gly Gly Ala
Gly Gly Gly Gly Cys Lys Pro 260 265 270Cys Ile Cys Thr Val Pro Glu
Val Ser Ser Val Phe Ile Phe Pro Pro 275 280 285Lys Pro Lys Asp Val
Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 290 295 300Val Val Val
Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp305 310 315
320Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu
325 330 335Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro
Ile Met 340 345 350His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys
Arg Val Asn Ser 355 360 365Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys Thr Lys Gly 370 375 380Arg Pro Lys Ala Pro Gln Val Tyr
Thr Ile Pro Pro Pro Lys Glu Gln385 390 395 400Met Ala Lys Asp Lys
Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe 405 410 415Pro Glu Asp
Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 420 425 430Asn
Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe 435 440
445Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn
450 455 460Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His
His Thr465 470 475 480Glu Lys Ser Leu Ser His Ser Pro Gly Lys 485
4901515PRTArtificial SequenceSynthetic Sequence 15Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser1 5 10
1516106PRTArtificial SequenceSynthetic Sequence 16Asp Ile Gln Leu
Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val
Thr Ile Thr Cys Ser Ala Ala Ser Ser Val Ser Tyr Ile 20 25 30Tyr Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ser
Thr Ser Thr Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55
60Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65
70 75 80Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Phe
Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100
10517106PRTArtificial SequenceSynthetic Sequence 17Asp Ile Gln Leu
Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val
Thr Ile Thr Cys Ser Ala Ala Ser Ser Val Ser Tyr Ile 20 25 30Tyr Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ser
Thr Ser Thr Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55
60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65
70 75 80Asp Phe Ala Thr Tyr
Tyr Cys His Gln Arg Asn Ser Phe Pro Phe Thr 85 90 95Phe Gly Gln Gly
Thr Lys Leu Glu Ile Lys 100 10518106PRTArtificial SequenceSynthetic
Sequence 18Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser
Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Ser Ala Ala Ser Ser Val
Ser Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile Tyr 35 40 45Ser Thr Ser Thr Leu Pro Ser Gly Val Pro Ser
Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile
Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His
Gln Arg Asn Ser Phe Pro Phe Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu
Glu Ile Lys 100 10519114PRTArtificial SequenceSynthetic Sequence
19Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr
Tyr 20 25 30Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser Ser Asp Tyr Thr Arg Tyr Asn
Pro Lys Phe 50 55 60Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr
Ser Thr Ala Tyr65 70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Gly Thr Arg Asp Tyr Trp Gly
Gln Gly Thr Thr Val Thr Val 100 105 110Ser Ser20114PRTArtificial
SequenceSynthetic Sequence 20Glu Val Gln Leu Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Thr Ile His Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser
Ser Asp Tyr Thr Arg Tyr Asn Pro Lys Phe 50 55 60Lys Asp Arg Val Thr
Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr65 70 75 80Met Glu Leu
Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Gln Arg
Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 100 105
110Ser Ser21114PRTArtificial SequenceSynthetic Sequence 21Glu Val
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25
30Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45Gly Tyr Ile Asn Pro Ser Ser Asp Tyr Thr Arg Tyr Asn Pro Lys
Phe 50 55 60Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr
Ala Tyr65 70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala
Val Tyr Tyr Cys 85 90 95Gln Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly
Thr Thr Val Thr Val 100 105 110Ser Ser22114PRTArtificial
SequenceSynthetic Sequence 22Glu Val Gln Leu Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Thr Ile His Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser
Ser Asp Tyr Thr Arg Tyr Asn Pro Lys Phe 50 55 60Lys Asp Arg Val Thr
Leu Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr65 70 75 80Met Glu Leu
Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Gln Arg
Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 100 105
110Ser Ser23114PRTArtificial SequenceSynthetic Sequence 23Glu Val
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25
30Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45Gly Tyr Ile Asn Pro Ser Ser Asp Tyr Thr Arg Tyr Asn Pro Lys
Phe 50 55 60Lys Asp Arg Val Thr Leu Thr Thr Asp Thr Ser Thr Ser Thr
Ala Tyr65 70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala
Val Tyr Tyr Cys 85 90 95Ala Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly
Thr Thr Val Thr Val 100 105 110Ser Ser24114PRTArtificial
SequenceSynthetic Sequence 24Glu Val Gln Leu Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Thr Ile His Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser
Ser Asp Tyr Thr Arg Tyr Asn Pro Lys Phe 50 55 60Lys Asp Arg Val Thr
Leu Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr65 70 75 80Met Glu Leu
Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Gln Thr
Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 100 105
110Ser Ser25114PRTArtificial SequenceSynthetic Sequence 25Glu Val
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25
30Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45Gly Tyr Ile Asn Pro Ser Ser Asp Tyr Thr Arg Tyr Asn Pro Lys
Phe 50 55 60Lys Asp Arg Val Thr Leu Thr Thr Asp Lys Ser Thr Ser Thr
Ala Tyr65 70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala
Val Tyr Tyr Cys 85 90 95Gln Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly
Thr Thr Val Thr Val 100 105 110Ser Ser26221PRTArtificial
SequenceSynthetic Sequence 26Glu Val Gln Leu Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Thr Ile His Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45Gly Tyr Ile Asn Pro Ser
Ser Asp Tyr Thr Arg Tyr Asn Pro Lys Phe 50 55 60Lys Asp Arg Val Thr
Leu Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr65 70 75 80Met Glu Leu
Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Gln Thr
Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 100 105
110Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser
115 120 125Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
Val Lys 130 135 140Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
Ser Gly Ala Leu145 150 155 160Thr Ser Gly Val His Thr Phe Pro Ala
Val Leu Gln Ser Ser Gly Leu 165 170 175Tyr Ser Leu Ser Ser Val Val
Thr Val Pro Ser Ser Ser Leu Gly Thr 180 185 190Gln Thr Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 195 200 205Asp Lys Lys
Val Glu Pro Lys Ser Cys Ala Ala Gly Ser 210 215
22027213PRTArtificial SequenceSynthetic Sequence 27Asp Ile Gln Leu
Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val
Thr Ile Thr Cys Ser Ala Ala Ser Ser Val Ser Tyr Ile 20 25 30Tyr Trp
Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ser
Thr Ser Thr Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55
60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65
70 75 80Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Phe
Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala
Ala Pro 100 105 110Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu
Lys Ser Gly Thr 115 120 125Ala Ser Val Val Cys Leu Leu Asn Asn Phe
Tyr Pro Arg Glu Ala Lys 130 135 140Val Gln Trp Lys Val Asp Asn Ala
Leu Gln Ser Gly Asn Ser Gln Glu145 150 155 160Ser Val Thr Glu Gln
Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 165 170 175Thr Leu Thr
Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 180 185 190Cys
Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 195 200
205Asn Arg Gly Glu Cys 21028221PRTArtificial SequenceSynthetic
Sequence 28Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro
Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
Thr Thr Tyr 20 25 30Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg
Tyr Asn Pro Lys Phe 50 55 60Lys Gly Arg Val Thr Met Thr Arg Asp Lys
Ser Thr Ser Thr Ala Tyr65 70 75 80Met Glu Leu Arg Ser Leu Arg Ser
Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Gln Thr Gly Thr Arg Asp Tyr
Trp Gly Gln Gly Thr Thr Val Thr Val 100 105 110Ser Ser Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 115 120 125Ser Lys Ser
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 130 135 140Asp
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu145 150
155 160Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
Leu 165 170 175Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
Leu Gly Thr 180 185 190Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
Ser Asn Thr Lys Val 195 200 205Asp Lys Lys Val Glu Pro Lys Ser Cys
Ala Ala Gly Ser 210 215 22029213PRTArtificial SequenceSynthetic
Sequence 29Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser
Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val
Ser Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile Tyr 35 40 45Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser
Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile
Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His
Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu
Glu Ile Lys Arg Thr Val Ala Ala Pro 100 105 110Ser Val Phe Ile Phe
Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 115 120 125Ala Ser Val
Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 130 135 140Val
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu145 150
155 160Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
Ser 165 170 175Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
Leu Tyr Ala 180 185 190Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
Val Thr Lys Ser Phe 195 200 205Asn Arg Gly Glu Cys
21030221PRTArtificial SequenceSynthetic Sequence 30Glu Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Thr Ile
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly
Tyr Ile Asn Pro Gly Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe 50 55
60Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr65
70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Gln Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val
Thr Val 100 105 110Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
Leu Ala Pro Ser 115 120 125Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
Leu Gly Cys Leu Val Lys 130 135 140Asp Tyr Phe Pro Glu Pro Val Thr
Val Ser Trp Asn Ser Gly Ala Leu145 150 155 160Thr Ser Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 165 170 175Tyr Ser Leu
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 180 185 190Gln
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 195 200
205Asp Lys Lys Val Glu Pro Lys Ser Cys Ala Ala Gly Ser 210 215
22031213PRTArtificial SequenceSynthetic Sequence 31Asp Ile Gln Leu
Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val
Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 20 25 30Tyr Trp
Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ala
Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55
60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65
70 75 80Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr
Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala
Ala Pro 100 105 110Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu
Lys Ser Gly Thr 115 120 125Ala Ser Val Val Cys Leu Leu Asn Asn Phe
Tyr Pro Arg Glu Ala Lys 130 135 140Val Gln Trp Lys Val Asp Asn Ala
Leu Gln Ser Gly Asn Ser Gln Glu145 150 155 160Ser Val Thr Glu Gln
Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 165 170 175Thr Leu Thr
Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu Tyr Ala 180 185 190Cys
Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 195 200
205Asn Arg Gly Glu Cys 21032106PRTArtificial SequenceSynthetic
Sequence 32Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser
Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val
Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile Tyr 35 40 45Ala Thr Ser Thr Leu Arg Ser Gly Val Pro Ser
Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile
Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His
Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu
Glu Ile Lys 100 10533114PRTArtificial SequenceSynthetic Sequence
33Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr
Tyr 20 25 30Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn
Pro Lys Phe 50 55
60Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr65
70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Gln Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val
Thr Val 100 105 110Ser Ser34106PRTArtificial SequenceSynthetic
Sequence 34Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser
Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val
Ser Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile Tyr 35 40 45Ala Thr Ser Thr Arg Gln Ser Gly Val Pro Ser
Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile
Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His
Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu
Glu Ile Lys 100 10535114PRTArtificial SequenceSynthetic Sequence
35Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr
Tyr 20 25 30Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser Ser Gly Trp Thr Arg Tyr Asn
Pro Lys Phe 50 55 60Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr
Ser Thr Ala Tyr65 70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95Trp Thr Gly Arg Arg Asp Tyr Trp Gly
Gln Gly Thr Thr Val Thr Val 100 105 110Ser Ser36106PRTArtificial
SequenceSynthetic Sequence 36Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Ser Ser Val Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ala Thr Ser Thr Leu Gln
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu
Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys 100 10537114PRTArtificial
SequenceSynthetic Sequence 37Glu Val Gln Leu Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Ala Ile His Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser
Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe 50 55 60Lys His Arg Val Thr
Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr65 70 75 80Met Glu Leu
Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Gln Thr
Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 100 105
110Ser Ser38106PRTArtificial SequenceSynthetic Sequence 38Asp Ile
Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp
Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 20 25
30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
35 40 45Ala Thr Ser Thr Arg Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln
Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser
Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100
10539114PRTArtificial SequenceSynthetic Sequence 39Glu Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 20 25 30Ala Ile
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly
Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe 50 55
60Lys His Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr65
70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Trp Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val
Thr Val 100 105 110Ser Ser40106PRTArtificial SequenceSynthetic
Sequence 40Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser
Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val
Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile Tyr 35 40 45Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser
Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile
Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His
Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu
Glu Ile Lys 100 10541114PRTArtificial SequenceSynthetic Sequence
41Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr
Tyr 20 25 30Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 35 40 45Gly Tyr Ile Asn Pro Lys Ser Gly Trp Thr Arg Tyr Asn
Pro Lys Phe 50 55 60Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr
Ser Thr Ala Tyr65 70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95Gln Thr Gly Thr Arg Asp Tyr Trp Gly
Gln Gly Thr Thr Val Thr Val 100 105 110Ser Ser42106PRTArtificial
SequenceSynthetic Sequence 42Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Ser Ser Val Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ala Thr Ser Phe Arg Gln
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu
Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys 100 10543114PRTArtificial
SequenceSynthetic Sequence 43Glu Val Gln Leu Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Thr Ile His Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser
Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe 50 55 60Lys Gly Arg Val Thr
Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr65 70 75 80Met Glu Leu
Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Gln Thr
Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 100 105
110Ser Ser44106PRTArtificial SequenceSynthetic Sequence 44Asp Ile
Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp
Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 20 25
30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
35 40 45Ala Thr Ser Phe Arg Arg Ser Gly Val Pro Ser Arg Phe Ser Gly
Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln
Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser
Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100
10545114PRTArtificial SequenceSynthetic Sequence 45Glu Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Ala Ile
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly
Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe 50 55
60Lys His Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr65
70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Trp Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val
Thr Val 100 105 110Ser Ser46106PRTArtificial SequenceSynthetic
Sequence 46Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser
Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val
Ser Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile Tyr 35 40 45Ala Thr Ser Thr Arg Gln Ser Gly Val Pro Ser
Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile
Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His
Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu
Glu Ile Lys 100 10547114PRTArtificial SequenceSynthetic Sequence
47Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr
Tyr 20 25 30Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn
Pro Lys Phe 50 55 60Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr
Ser Thr Ala Tyr65 70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95Trp Thr Gly Thr Arg Asp Tyr Trp Gly
Gln Gly Thr Thr Val Thr Val 100 105 110Ser Ser48106PRTArtificial
SequenceSynthetic Sequence 48Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Ser Ser Val Ser Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ala Thr Ser Phe Arg Gln
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu
Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys 100 10549114PRTArtificial
SequenceSynthetic Sequence 49Glu Val Gln Leu Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Thr Ile His Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Tyr Ile Asn Pro Lys
Ser Gly Trp Thr Arg Tyr Asn Pro Lys Phe 50 55 60Lys Gly Arg Val Thr
Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr65 70 75 80Met Glu Leu
Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Gln Thr
Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 100 105
110Ser Ser50106PRTArtificial SequenceSynthetic Sequence 50Asp Ile
Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp
Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 20 25
30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
35 40 45Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln
Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser
Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100
10551114PRTArtificial SequenceSynthetic Sequence 51Glu Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Thr Ile
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly
Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe 50 55
60Lys His Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr65
70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Trp Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val
Thr Val 100 105 110Ser Ser52106PRTArtificial SequenceSynthetic
Sequence 52Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser
Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val
Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile Tyr 35 40 45Ala Thr Ser Phe Leu Gln Ser Gly Val Pro Ser
Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile
Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His
Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu
Glu Ile Lys 100 10553114PRTArtificial SequenceSynthetic Sequence
53Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr
Tyr 20 25 30Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn
Pro Lys Phe 50 55 60Lys His Arg Val Thr Met Thr Arg Asp Lys Ser Thr
Ser Thr Ala Tyr65 70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95Trp Thr Gly Thr Arg Asp Tyr Trp Gly
Gln Gly Thr Thr Val Thr Val 100 105 110Ser Ser54106PRTArtificial
SequenceSynthetic Sequence 54Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Ser Ser Val Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ala Thr Ser Thr Leu Arg
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu
Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys
100 10555114PRTArtificial SequenceSynthetic Sequence 55Glu Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val
Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Ala
Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40
45Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe
50 55 60Lys His Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Ala
Tyr65 70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val
Tyr Tyr Cys 85 90 95Trp Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr
Thr Val Thr Val 100 105 110Ser Ser56106PRTArtificial
SequenceSynthetic Sequence 56Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Ser Ser Val Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ala Thr Ser Phe Arg Gln
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu
Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys 100 10557114PRTArtificial
SequenceSynthetic Sequence 57Glu Val Gln Leu Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Ala Ile His Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser
Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe 50 55 60Lys Gly Arg Val Thr
Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr65 70 75 80Met Glu Leu
Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Trp Thr
Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 100 105
110Ser Ser58106PRTArtificial SequenceSynthetic Sequence 58Asp Ile
Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp
Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 20 25
30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
35 40 45Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln
Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser
Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100
10559114PRTArtificial SequenceSynthetic Sequence 59Glu Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 20 25 30Thr Ile
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly
Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe 50 55
60Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr65
70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Trp Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val
Thr Val 100 105 110Ser Ser60106PRTArtificial SequenceSynthetic
Sequence 60Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser
Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val
Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile Tyr 35 40 45Ala Thr Ser Phe Arg Gln Ser Gly Val Pro Ser
Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile
Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His
Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu
Glu Ile Lys 100 10561114PRTArtificial SequenceSynthetic Sequence
61Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr
Tyr 20 25 30Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn
Pro Lys Phe 50 55 60Lys His Arg Val Thr Met Thr Arg Asp Lys Ser Thr
Ser Thr Ala Tyr65 70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95Trp Thr Gly Thr Arg Asp Tyr Trp Gly
Gln Gly Thr Thr Val Thr Val 100 105 110Ser Ser62106PRTArtificial
SequenceSynthetic Sequence 62Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Ser Ser Val Ser Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ala Thr Ser Phe Leu Gln
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu
Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys 100 10563114PRTArtificial
SequenceSynthetic Sequence 63Glu Val Gln Leu Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Thr Ile His Trp Val Arg Gln
Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Tyr Ile Asn Pro Lys
Ser Gly Trp Thr Arg Tyr Asn Pro Lys Phe 50 55 60Lys Gly Arg Val Thr
Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr65 70 75 80Met Glu Leu
Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Gln Thr
Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 100 105
110Ser Ser64106PRTArtificial SequenceSynthetic Sequence 64Asp Ile
Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp
Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 20 25
30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
35 40 45Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln
Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser
Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100
10565114PRTArtificial SequenceSynthetic Sequence 65Glu Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30Thr Ile
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly
Tyr Ile Asn Pro Lys Ser Gly Trp Thr Arg Tyr Asn Pro Lys Phe 50 55
60Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr65
70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Gln Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val
Thr Val 100 105 110Ser Ser66106PRTArtificial SequenceSynthetic
Sequence 66Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser
Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val
Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile Tyr 35 40 45Ala Thr Ser Phe Arg Gln Ser Gly Val Pro Ser
Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile
Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His
Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu
Glu Ile Lys 100 10567114PRTArtificial SequenceSynthetic Sequence
67Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr
Tyr 20 25 30Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 35 40 45Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn
Pro Lys Phe 50 55 60Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr
Ser Thr Ala Tyr65 70 75 80Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95Trp Thr Gly Arg Arg Asp Tyr Trp Gly
Gln Gly Thr Thr Val Thr Val 100 105 110Ser Ser6820PRTArtificial
SequenceSynthetic Sequence 68Glu Val Ser Glu Ile Ser Val Arg Thr
Val Tyr Pro Pro Glu Glu Glu1 5 10 15Thr Gly Glu Arg
20698PRTArtificial SequenceSynthetic Sequence 69Ser Val Arg Thr Val
Tyr Pro Pro1 5708PRTArtificial SequenceSynthetic Sequence 70Val Arg
Thr Val Tyr Pro Pro Glu1 5718PRTArtificial SequenceSynthetic
Sequence 71Arg Thr Val Tyr Pro Pro Glu Glu1 5728PRTArtificial
SequenceSynthetic Sequence 72Thr Val Tyr Pro Pro Glu Glu Glu1
5738PRTArtificial SequenceSynthetic Sequence 73Val Tyr Pro Pro Glu
Glu Glu Thr1 5748PRTArtificial SequenceSynthetic Sequence 74Tyr Pro
Pro Glu Glu Glu Thr Gly1 5758PRTArtificial SequenceSynthetic
Sequence 75Pro Pro Glu Glu Glu Thr Gly Glu1 5768PRTArtificial
SequenceSynthetic Sequence 76Pro Glu Glu Glu Thr Gly Glu Arg1
5778PRTArtificial SequenceSynthetic Sequence 77Glu Glu Glu Thr Gly
Glu Arg Val1 5788PRTArtificial SequenceSynthetic Sequence 78Glu Glu
Thr Gly Glu Arg Val Gln1 57920PRTArtificial SequenceSynthetic
Sequence 79Ala Val Ser Glu Ile Ser Val Arg Thr Val Tyr Pro Pro Glu
Glu Glu1 5 10 15Thr Gly Glu Arg 208020PRTArtificial
SequenceSynthetic Sequence 80Glu Ala Ser Glu Ile Ser Val Arg Thr
Val Tyr Pro Pro Glu Glu Glu1 5 10 15Thr Gly Glu Arg
208120PRTArtificial SequenceSynthetic Sequence 81Glu Val Ala Glu
Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu1 5 10 15Thr Gly Glu
Arg 208220PRTArtificial SequenceSynthetic Sequence 82Glu Val Ser
Ala Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu1 5 10 15Thr Gly
Glu Arg 208320PRTArtificial SequenceSynthetic Sequence 83Glu Val
Ser Glu Ala Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu1 5 10 15Thr
Gly Glu Arg 208420PRTArtificial SequenceSynthetic Sequence 84Glu
Val Ser Glu Ile Ala Val Arg Thr Val Tyr Pro Pro Glu Glu Glu1 5 10
15Thr Gly Glu Arg 208520PRTArtificial SequenceSynthetic Sequence
85Glu Val Ser Glu Ile Ser Ala Arg Thr Val Tyr Pro Pro Glu Glu Glu1
5 10 15Thr Gly Glu Arg 208620PRTArtificial SequenceSynthetic
Sequence 86Glu Val Ser Glu Ile Ser Val Ala Thr Val Tyr Pro Pro Glu
Glu Glu1 5 10 15Thr Gly Glu Arg 208720PRTArtificial
SequenceSynthetic Sequence 87Glu Val Ser Glu Ile Ser Val Arg Ala
Val Tyr Pro Pro Glu Glu Glu1 5 10 15Thr Gly Glu Arg
208820PRTArtificial SequenceSynthetic Sequence 88Glu Val Ser Glu
Ile Ser Val Arg Thr Ala Tyr Pro Pro Glu Glu Glu1 5 10 15Thr Gly Glu
Arg 208920PRTArtificial SequenceSynthetic Sequence 89Glu Val Ser
Glu Ile Ser Val Arg Thr Val Ala Pro Pro Glu Glu Glu1 5 10 15Thr Gly
Glu Arg 209020PRTArtificial SequenceSynthetic Sequence 90Glu Val
Ser Glu Ile Ser Val Arg Thr Val Tyr Ala Pro Glu Glu Glu1 5 10 15Thr
Gly Glu Arg 209120PRTArtificial SequenceSynthetic Sequence 91Glu
Val Ser Glu Ile Ser Val Arg Thr Val Tyr Pro Ala Glu Glu Glu1 5 10
15Thr Gly Glu Arg 209220PRTArtificial SequenceSynthetic Sequence
92Glu Val Ser Glu Ile Ser Val Arg Thr Val Tyr Pro Pro Ala Glu Glu1
5 10 15Thr Gly Glu Arg 209320PRTArtificial SequenceSynthetic
Sequence 93Glu Val Ser Glu Ile Ser Val Arg Thr Val Tyr Pro Pro Glu
Ala Glu1 5 10 15Thr Gly Glu Arg 209420PRTArtificial
SequenceSynthetic Sequence 94Glu Val Ser Glu Ile Ser Val Arg Thr
Val Tyr Pro Pro Glu Glu Ala1 5 10 15Thr Gly Glu Arg
209520PRTArtificial SequenceSynthetic Sequence 95Glu Val Ser Glu
Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu1 5 10 15Ala Gly Glu
Arg 209620PRTArtificial SequenceSynthetic Sequence 96Glu Val Ser
Glu Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu1 5 10 15Thr Ala
Glu Arg 209720PRTArtificial SequenceSynthetic Sequence 97Glu Val
Ser Glu Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu1 5 10 15Thr
Gly Ala Arg 209820PRTArtificial SequenceSynthetic Sequence 98Glu
Val Ser Glu Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu1 5 10
15Thr Gly Glu Ala 20998PRTArtificial SequenceSynthetic Sequence
99Ser Val Arg Thr Val Tyr Pro Pro1 51008PRTArtificial
SequenceSynthetic Sequence 100Val Arg Thr Val Tyr Pro Pro Glu1
51018PRTArtificial SequenceSynthetic Sequence 101Arg Thr Val Tyr
Pro Pro Glu Glu1 51028PRTArtificial SequenceSynthetic Sequence
102Thr Val Tyr Pro Pro Glu Glu Glu1 51038PRTArtificial
SequenceSynthetic Sequence 103Val Tyr Pro Pro Glu Glu Glu Thr1
51048PRTArtificial SequenceSynthetic Sequence 104Tyr Pro Pro Glu
Glu Glu Thr Gly1 51058PRTArtificial SequenceSynthetic Sequence
105Pro Pro Glu Glu Glu Thr Gly Glu1 510615PRTArtificial
SequenceSynthetic Sequence 106Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser1 5 10 1510720PRTArtificial
SequenceSynthetic Sequence 107Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly1 5 10 15Gly Gly Gly Ser
201086PRTArtificial SequenceSynthetic Sequence 108Leu Val Pro Arg
Gly Ser1 510926PRTArtificial SequenceSynthetic Sequence 109Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Leu Val Pro Arg Gly Ser1 5 10 15Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly 20 2511029PRTArtificial
SequenceSynthetic Sequence 110Gly Gly Glu Gly Arg Thr Ala Thr Gly
Gly Gly Ser Gly Leu Val Pro1 5 10 15Arg Gly Ser Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 20 251117PRTArtificial SequenceSynthetic
Sequence 111Gly Glu Gly Arg Thr Ala Thr1 511222PRTArtificial
SequenceSynthetic Sequence 112Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Leu Val Pro Arg1 5 10 15Gly Ser Gly
Gly Gly Gly 201131715PRTArtificial SequenceSynthetic Sequence
113Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1
5 10 15Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro
Pro 20 25 30Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr
Lys Lys 35 40 45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile
Ala Lys Pro 50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile
Gln Ala Glu Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn
Met Ala Ser His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr
Trp Lys Ala Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser
Gln Arg Glu Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser
His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met
Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155
160His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu
165 170 175Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln
Thr Leu 180 185 190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu
Gly Lys Ser Trp 195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln
Asp Arg Asp Ala Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His
Thr Val Asn Gly Tyr Val Asn Arg225 230 235 240Ser Leu Pro Gly Leu
Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 245 250 255Val Ile Gly
Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270Gly
His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280
285Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly
290 295 300Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp
Gly Met305 310 315 320Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu
Glu Pro Gln Leu Arg 325 330 335Met Lys Asn Asn Glu Glu Ala Glu Asp
Tyr Asp Asp Asp Leu Thr Asp 340 345 350Ser Glu Met Asp Val Val Arg
Phe Asp Asp Asp Asn Ser Pro Ser Phe 355 360 365Ile Gln Ile Arg Ser
Val Ala Lys Lys His Pro Lys Thr Trp Val His 370 375 380Tyr Ile Ala
Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu385 390 395
400Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro
405 410 415Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala
Tyr Thr 420 425 430Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His
Glu Ser Gly Ile 435 440 445Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly
Asp Thr Leu Leu Ile Ile 450 455 460Phe Lys Asn Gln Ala Ser Arg Pro
Tyr Asn Ile Tyr Pro His Gly Ile465 470 475 480Thr Asp Val Arg Pro
Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 485 490 495His Leu Lys
Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510Trp
Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520
525Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala
530 535 540Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser
Val Asp545 550 555 560Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg
Asn Val Ile Leu Phe 565 570 575Ser Val Phe Asp Glu Asn Arg Ser Trp
Tyr Leu Thr Glu Asn Ile Gln 580 585 590Arg Phe Leu Pro Asn Pro Ala
Gly Val Gln Leu Glu Asp Pro Glu Phe 595 600 605Gln Ala Ser Asn Ile
Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 610 615 620Leu Gln Leu
Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu625 630 635
640Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr
645 650 655Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu
Phe Pro 660 665 670Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn
Pro Gly Leu Trp 675 680 685Ile Leu Gly Cys His Asn Ser Asp Phe Arg
Asn Arg Gly Met Thr Ala 690 695 700Leu Leu Lys Val Ser Ser Cys Asp
Lys Asn Thr Gly Asp Tyr Tyr Glu705 710 715 720Asp Ser Tyr Glu Asp
Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 725 730 735Ile Glu Pro
Arg Ser Phe Ser Gln Asn Gly Gly Gly Gly Ser Thr Gly 740 745 750Gly
Thr Gly Gly Ser Ser Gly Gly Gly Thr Gly Ser Gly Gly Gly Gly 755 760
765Thr Gly Gly Ser Gly Gly Thr Asp Ile Gln Leu Thr Gln Ser Pro Ser
770 775 780Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
Arg Ala785 790 795 800Ser Ser Ser Val Ser Tyr Ile Tyr Trp Phe Gln
Gln Lys Pro Gly Lys 805 810 815Ala Pro Lys Leu Leu Ile Tyr Ala Thr
Ser Thr Leu Gln Ser Gly Val 820 825 830Pro Ser Arg Phe Ser Gly Ser
Gly Ser Gly Thr Glu Tyr Thr Leu Thr 835 840 845Ile Ser Ser Leu Gln
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln 850 855 860Arg Asn Ser
Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile865 870 875
880Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
885 890 895Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala
Glu Val 900 905 910Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys
Ala Ser Gly Tyr 915 920 925Thr Phe Thr Thr Tyr Thr Ile His Trp Val
Arg Gln Ala Pro Gly Gln 930 935 940Gly Leu Glu Trp Met Gly Tyr Ile
Asn Pro Ser Ser Gly Tyr Thr Arg945 950 955 960Tyr Asn Pro Lys Phe
Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser 965 970 975Thr Ser Thr
Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr 980 985 990Ala
Val Tyr Tyr Cys Gln Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly 995
1000 1005Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Asn
Pro 1010 1015 1020Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg
Thr Thr Leu 1025 1030 1035Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp
Asp Thr Ile Ser Val 1040 1045 1050Glu Met Lys Lys Glu Asp Phe Asp
Ile Phe Asp Glu Asp Glu Asn 1055 1060 1065Gln Ser Pro Arg Ser Phe
Gln Lys Lys Thr Arg His Tyr Phe Ile 1070 1075 1080Ala Ala Val Glu
Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro 1085 1090 1095His Val
Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe 1100 1105
1110Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln
1115 1120 1125Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu
Leu Gly 1130 1135 1140Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile
Met Val Thr Phe 1145 1150 1155Arg Asn Gln Ala Ser Arg Pro Tyr Ser
Phe Tyr Ser Ser Leu Ile 1160 1165 1170Ser Tyr Glu Glu Asp Gln Arg
Gln Gly Ala Glu Pro Arg Lys Asn 1175 1180 1185Phe Val Lys Pro Asn
Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln 1190 1195 1200His His Met
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 1205 1210 1215Ala
Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly 1220 1225
1230Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro
1235 1240 1245Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu
Phe Phe 1250 1255 1260Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe
Thr Glu Asn Met 1265 1270 1275Glu Arg Asn Cys Arg Ala Pro Cys Asn
Ile Gln Met Glu Asp Pro 1280 1285 1290Thr Phe Lys Glu Asn Tyr Arg
Phe His Ala Ile Asn Gly Tyr Ile 1295 1300 1305Met Asp Thr Leu Pro
Gly Leu Val Met Ala Gln Asp Gln Arg Ile 1310 1315 1320Arg Trp Tyr
Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser 1325 1330 1335Ile
His Phe Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu 1340 1345
1350Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr
1355 1360 1365Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val
Glu Cys 1370 1375 1380Leu Ile Gly Glu His Leu His Ala Gly Met Ser
Thr Leu Phe Leu 1385 1390 1395Val Tyr Ser Asn Lys Cys Gln Thr Pro
Leu Gly Met Ala Ser Gly 1400 1405 1410His Ile Arg Asp Phe Gln Ile
Thr Ala Ser Gly Gln Tyr Gly Gln 1415 1420 1425Trp Ala Pro Lys Leu
Ala Arg Leu His Tyr Ser Gly Ser Ile Asn 1430 1435 1440Ala Trp Ser
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu 1445 1450 1455Leu
Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg 1460 1465
1470Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr
1475 1480 1485Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn
Ser Thr 1490 1495 1500Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp
Ser Ser Gly Ile 1505 1510 1515Lys His Asn Ile Phe Asn Pro Pro Ile
Ile Ala Arg Tyr Ile Arg 1520 1525 1530Leu His Pro Thr His Tyr Ser
Ile Arg Ser Thr Leu Arg Met Glu 1535 1540 1545Leu Met Gly Cys Asp
Leu Asn Ser Cys Ser Met Pro Leu Gly Met 1550 1555 1560Glu Ser Lys
Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr 1565 1570 1575Phe
Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu 1580 1585
1590His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn
1595 1600 1605Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met
Lys Val 1610 1615 1620Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu
Leu Thr Ser Met 1625 1630 1635Tyr Val Lys Glu Phe Leu Ile Ser Ser
Ser Gln Asp Gly His Gln 1640 1645 1650Trp Thr Leu Phe Phe Gln Asn
Gly Lys Val Lys Val Phe Gln Gly 1655 1660 1665Asn Gln Asp Ser Phe
Thr Pro Val Val Asn Ser Leu Asp Pro Pro 1670 1675 1680Leu Leu Thr
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His 1685 1690 1695Gln
Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp 1700 1705
1710Leu Tyr 17151141680PRTArtificial SequenceSynthetic Sequence
114Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1
5 10 15Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro
Pro 20 25 30Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr
Lys Lys 35 40 45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile
Ala Lys Pro 50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile
Gln Ala Glu Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn
Met Ala Ser His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr
Trp Lys Ala Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser
Gln Arg Glu Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser
His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met
Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155
160His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu
165 170 175Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln
Thr Leu 180 185 190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu
Gly Lys Ser Trp 195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln
Asp Arg Asp Ala Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His
Thr Val Asn Gly Tyr Val Asn Arg225 230 235 240Ser Leu Pro Gly Leu
Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 245 250 255Val Ile Gly
Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270Gly
His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280
285Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly
290 295 300Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp
Gly Met305 310 315 320Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu
Glu Pro Gln Leu Arg 325 330 335Met Lys Asn Asn Glu Glu Ala Glu Asp
Tyr Asp Asp Asp Leu Thr Asp 340 345 350Ser Glu Met Asp Val Val Arg
Phe Asp Asp Asp Asn Ser Pro Ser Phe 355 360 365Ile Gln Ile Arg Ser
Val Ala Lys Lys His Pro Lys Thr Trp Val His 370 375 380Tyr Ile Ala
Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu385 390 395
400Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro
405 410 415Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala
Tyr Thr 420 425 430Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His
Glu Ser Gly Ile 435 440 445Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly
Asp Thr Leu Leu Ile Ile 450 455 460Phe Lys Asn Gln Ala Ser Arg Pro
Tyr Asn Ile Tyr Pro His Gly Ile465 470 475 480Thr Asp Val Arg Pro
Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 485 490 495His Leu Lys
Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510Trp
Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520
525Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala
530 535 540Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser
Val Asp545 550 555 560Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg
Asn Val Ile Leu Phe 565 570 575Ser Val Phe Asp Glu Asn Arg Ser Trp
Tyr Leu Thr Glu Asn Ile Gln 580 585 590Arg Phe Leu Pro Asn Pro Ala
Gly Val Gln Leu Glu Asp Pro Glu Phe 595 600 605Gln Ala Ser Asn Ile
Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 610 615 620Leu Gln Leu
Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu625 630 635
640Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr
645 650 655Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu
Phe Pro 660 665 670Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn
Pro Gly Leu Trp 675 680 685Ile Leu Gly Cys His Asn Ser Asp Phe Arg
Asn Arg Gly Met Thr Ala 690 695 700Leu Leu Lys Val Ser Ser Cys Asp
Lys Asn Thr Gly Asp Tyr Tyr Glu705 710 715 720Asp Ser Tyr Glu Asp
Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 725
730 735Ile Glu Pro Arg Ser Phe Ser Gln Asn Gly Gly Gly Gly Ser Thr
Gly 740 745 750Gly Thr Gly Gly Ser Ser Gly Gly Gly Thr Gly Ser Gly
Gly Gly Gly 755 760 765Thr Gly Gly Ser Gly Gly Thr Asp Ile Gln Leu
Thr Gln Ser Pro Ser 770 775 780Phe Leu Ser Ala Ser Val Gly Asp Arg
Val Thr Ile Thr Cys Arg Ala785 790 795 800Ser Ser Ser Val Ser Tyr
Ile Tyr Trp Phe Gln Gln Lys Pro Gly Lys 805 810 815Ala Pro Lys Leu
Leu Ile Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val 820 825 830Pro Ser
Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr 835 840
845Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln
850 855 860Arg Asn Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu
Glu Ile865 870 875 880Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 885 890 895Gly Gly Gly Gly Ser Glu Val Gln Leu
Val Gln Ser Gly Ala Glu Val 900 905 910Lys Lys Pro Gly Ala Ser Val
Lys Val Ser Cys Lys Ala Ser Gly Tyr 915 920 925Thr Phe Thr Thr Tyr
Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln 930 935 940Gly Leu Glu
Trp Met Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg945 950 955
960Tyr Asn Pro Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser
965 970 975Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp
Asp Thr 980 985 990Ala Val Tyr Tyr Cys Gln Thr Gly Thr Arg Asp Tyr
Trp Gly Gln Gly 995 1000 1005Thr Thr Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly Gly 1010 1015 1020Gly Ser Gly Gly Gly Gly Ser
Asp Glu Asn Gln Ser Pro Arg Ser 1025 1030 1035Phe Gln Lys Lys Thr
Arg His Tyr Phe Ile Ala Ala Val Glu Arg 1040 1045 1050Leu Trp Asp
Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn 1055 1060 1065Arg
Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe 1070 1075
1080Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly
1085 1090 1095Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile
Arg Ala 1100 1105 1110Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg
Asn Gln Ala Ser 1115 1120 1125Arg Pro Tyr Ser Phe Tyr Ser Ser Leu
Ile Ser Tyr Glu Glu Asp 1130 1135 1140Gln Arg Gln Gly Ala Glu Pro
Arg Lys Asn Phe Val Lys Pro Asn 1145 1150 1155Glu Thr Lys Thr Tyr
Phe Trp Lys Val Gln His His Met Ala Pro 1160 1165 1170Thr Lys Asp
Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp 1175 1180 1185Val
Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 1190 1195
1200Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln
1205 1210 1215Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe
Asp Glu 1220 1225 1230Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu
Arg Asn Cys Arg 1235 1240 1245Ala Pro Cys Asn Ile Gln Met Glu Asp
Pro Thr Phe Lys Glu Asn 1250 1255 1260Tyr Arg Phe His Ala Ile Asn
Gly Tyr Ile Met Asp Thr Leu Pro 1265 1270 1275Gly Leu Val Met Ala
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu 1280 1285 1290Ser Met Gly
Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly 1295 1300 1305His
Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu 1310 1315
1320Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro
1325 1330 1335Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly
Glu His 1340 1345 1350Leu His Ala Gly Met Ser Thr Leu Phe Leu Val
Tyr Ser Asn Lys 1355 1360 1365Cys Gln Thr Pro Leu Gly Met Ala Ser
Gly His Ile Arg Asp Phe 1370 1375 1380Gln Ile Thr Ala Ser Gly Gln
Tyr Gly Gln Trp Ala Pro Lys Leu 1385 1390 1395Ala Arg Leu His Tyr
Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys 1400 1405 1410Glu Pro Phe
Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile 1415 1420 1425Ile
His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 1430 1435
1440Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys
1445 1450 1455Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu
Met Val 1460 1465 1470Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys
His Asn Ile Phe 1475 1480 1485Asn Pro Pro Ile Ile Ala Arg Tyr Ile
Arg Leu His Pro Thr His 1490 1495 1500Tyr Ser Ile Arg Ser Thr Leu
Arg Met Glu Leu Met Gly Cys Asp 1505 1510 1515Leu Asn Ser Cys Ser
Met Pro Leu Gly Met Glu Ser Lys Ala Ile 1520 1525 1530Ser Asp Ala
Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe 1535 1540 1545Ala
Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg 1550 1555
1560Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu
1565 1570 1575Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val
Thr Thr 1580 1585 1590Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr
Val Lys Glu Phe 1595 1600 1605Leu Ile Ser Ser Ser Gln Asp Gly His
Gln Trp Thr Leu Phe Phe 1610 1615 1620Gln Asn Gly Lys Val Lys Val
Phe Gln Gly Asn Gln Asp Ser Phe 1625 1630 1635Thr Pro Val Val Asn
Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr 1640 1645 1650Leu Arg Ile
His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg 1655 1660 1665Met
Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 1670 1675
16801151684PRTArtificial SequenceSynthetic Sequence 115Ala Thr Arg
Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1 5 10 15Met Gln
Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25 30Arg
Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 35 40
45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro
50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu
Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser
His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala
Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu
Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser His Thr Tyr
Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met Ala Ser Asp
Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155 160His Val Asp
Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170 175Leu
Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 180 185
190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp
195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala
Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly
Tyr Val Asn Arg225 230 235 240Ser Leu Pro Gly Leu Ile Gly Cys His
Arg Lys Ser Val Tyr Trp His 245 250 255Val Ile Gly Met Gly Thr Thr
Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270Gly His Thr Phe Leu
Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285Ser Pro Ile
Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295 300Gln
Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met305 310
315 320Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu
Arg 325 330 335Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp
Leu Thr Asp 340 345 350Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp
Asn Ser Pro Ser Phe 355 360 365Ile Gln Ile Arg Ser Val Ala Lys Lys
His Pro Lys Thr Trp Val His 370 375 380Tyr Ile Ala Ala Glu Glu Glu
Asp Trp Asp Tyr Ala Pro Leu Val Leu385 390 395 400Ala Pro Asp Asp
Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410 415Gln Arg
Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 420 425
430Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile
435 440 445Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu
Ile Ile 450 455 460Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr
Pro His Gly Ile465 470 475 480Thr Asp Val Arg Pro Leu Tyr Ser Arg
Arg Leu Pro Lys Gly Val Lys 485 490 495His Leu Lys Asp Phe Pro Ile
Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510Trp Thr Val Thr Val
Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525Leu Thr Arg
Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535 540Ser
Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp545 550
555 560Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu
Phe 565 570 575Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu
Asn Ile Gln 580 585 590Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu
Glu Asp Pro Glu Phe 595 600 605Gln Ala Ser Asn Ile Met His Ser Ile
Asn Gly Tyr Val Phe Asp Ser 610 615 620Leu Gln Leu Ser Val Cys Leu
His Glu Val Ala Tyr Trp Tyr Ile Leu625 630 635 640Ser Ile Gly Ala
Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 645 650 655Thr Phe
Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 660 665
670Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp
675 680 685Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met
Thr Ala 690 695 700Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly
Asp Tyr Tyr Glu705 710 715 720Asp Ser Tyr Glu Asp Ile Ser Ala Tyr
Leu Leu Ser Lys Asn Asn Ala 725 730 735Ile Glu Pro Arg Ser Phe Ser
Gln Asn Gly Gly Gly Gly Ser Thr Gly 740 745 750Gly Thr Gly Gly Ser
Ser Gly Gly Gly Thr Gly Ser Gly Gly Gly Gly 755 760 765Thr Gly Gly
Ser Gly Gly Thr Asp Ile Gln Leu Thr Gln Ser Pro Ser 770 775 780Phe
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala785 790
795 800Ser Ser Ser Val Arg Tyr Ile Tyr Trp Phe Gln Gln Lys Pro Gly
Lys 805 810 815Ala Pro Lys Leu Leu Ile Tyr Ala Thr Ser Phe Arg Gln
Ser Gly Val 820 825 830Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
Glu Tyr Thr Leu Thr 835 840 845Ile Ser Ser Leu Gln Pro Glu Asp Phe
Ala Thr Tyr Tyr Cys His Gln 850 855 860Arg Asn Ser Phe Pro Tyr Thr
Phe Gly Gln Gly Thr Lys Leu Glu Ile865 870 875 880Lys Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 885 890 895Gly Gly
Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 900 905
910Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
915 920 925Thr Phe Thr Thr Tyr Ala Ile His Trp Val Arg Gln Ala Pro
Gly Gln 930 935 940Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Ser
Gly Tyr Thr Arg945 950 955 960Tyr Asn Pro Lys Phe Lys Gly Arg Val
Thr Met Thr Arg Asp Lys Ser 965 970 975Thr Ser Thr Ala Tyr Met Glu
Leu Arg Ser Leu Arg Ser Asp Asp Thr 980 985 990Ala Val Tyr Tyr Cys
Trp Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly 995 1000 1005Thr Thr
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Asn Pro 1010 1015
1020Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Asp Glu Asn Gln
1025 1030 1035Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe
Ile Ala 1040 1045 1050Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser
Ser Ser Pro His 1055 1060 1065Val Leu Arg Asn Arg Ala Gln Ser Gly
Ser Val Pro Gln Phe Lys 1070 1075 1080Lys Val Val Phe Gln Glu Phe
Thr Asp Gly Ser Phe Thr Gln Pro 1085 1090 1095Leu Tyr Arg Gly Glu
Leu Asn Glu His Leu Gly Leu Leu Gly Pro 1100 1105 1110Tyr Ile Arg
Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg 1115 1120 1125Asn
Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 1130 1135
1140Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe
1145 1150 1155Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val
Gln His 1160 1165 1170His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys
Lys Ala Trp Ala 1175 1180 1185Tyr Phe Ser Asp Val Asp Leu Glu Lys
Asp Val His Ser Gly Leu 1190 1195 1200Ile Gly Pro Leu Leu Val Cys
His Thr Asn Thr Leu Asn Pro Ala 1205 1210 1215His Gly Arg Gln Val
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr 1220 1225 1230Ile Phe Asp
Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu 1235 1240 1245Arg
Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr 1250 1255
1260Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met
1265 1270 1275Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg
Ile Arg 1280 1285 1290Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn
Ile His Ser Ile 1295 1300 1305His Phe Ser Gly His Val Phe Thr Val
Arg Lys Lys Glu Glu Tyr 1310 1315 1320Lys Met Ala Leu Tyr Asn Leu
Tyr Pro Gly Val Phe Glu Thr Val 1325 1330 1335Glu Met Leu Pro Ser
Lys Ala Gly Ile Trp Arg Val Glu Cys Leu 1340 1345 1350Ile Gly Glu
His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val 1355 1360 1365Tyr
Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 1370 1375
1380Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp
1385 1390 1395Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile
Asn Ala 1400 1405 1410Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys
Val Asp Leu Leu 1415 1420 1425Ala Pro Met Ile Ile His Gly Ile Lys
Thr Gln Gly Ala Arg Gln 1430 1435 1440Lys Phe Ser Ser Leu Tyr Ile
Ser Gln Phe Ile Ile Met Tyr Ser 1445 1450 1455Leu Asp Gly Lys Lys
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly 1460 1465 1470Thr Leu Met
Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys 1475 1480 1485His
Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu 1490
1495 1500His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu
Leu 1505 1510 1515Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu
Gly Met Glu 1520 1525 1530Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr
Ala Ser Ser Tyr Phe 1535 1540 1545Thr Asn Met Phe Ala Thr Trp Ser
Pro Ser Lys Ala Arg Leu His 1550 1555 1560Leu Gln Gly Arg Ser Asn
Ala Trp Arg Pro Gln Val Asn Asn Pro 1565 1570 1575Lys Glu Trp Leu
Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr 1580 1585 1590Gly Val
Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr 1595 1600
1605Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp
1610 1615 1620Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln
Gly Asn 1625 1630 1635Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu
Asp Pro Pro Leu 1640 1645 1650Leu Thr Arg Tyr Leu Arg Ile His Pro
Gln Ser Trp Val His Gln 1655 1660 1665Ile Ala Leu Arg Met Glu Val
Leu Gly Cys Glu Ala Gln Asp Leu 1670 1675
1680Tyr1161684PRTArtificial SequenceSynthetic Sequence 116Ala Thr
Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1 5 10 15Met
Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25
30Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys
35 40 45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys
Pro 50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala
Glu Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala
Ser His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys
Ala Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser Gln Arg
Glu Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser His Thr
Tyr Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met Ala Ser
Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155 160His Val
Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170
175Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu
180 185 190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys
Ser Trp 195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg
Asp Ala Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His Thr Val
Asn Gly Tyr Val Asn Arg225 230 235 240Ser Leu Pro Gly Leu Ile Gly
Cys His Arg Lys Ser Val Tyr Trp His 245 250 255Val Ile Gly Met Gly
Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270Gly His Thr
Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285Ser
Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295
300Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly
Met305 310 315 320Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu
Pro Gln Leu Arg 325 330 335Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr
Asp Asp Asp Leu Thr Asp 340 345 350Ser Glu Met Asp Val Val Arg Phe
Asp Asp Asp Asn Ser Pro Ser Phe 355 360 365Ile Gln Ile Arg Ser Val
Ala Lys Lys His Pro Lys Thr Trp Val His 370 375 380Tyr Ile Ala Ala
Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu385 390 395 400Ala
Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410
415Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr
420 425 430Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser
Gly Ile 435 440 445Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr
Leu Leu Ile Ile 450 455 460Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn
Ile Tyr Pro His Gly Ile465 470 475 480Thr Asp Val Arg Pro Leu Tyr
Ser Arg Arg Leu Pro Lys Gly Val Lys 485 490 495His Leu Lys Asp Phe
Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510Trp Thr Val
Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525Leu
Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535
540Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val
Asp545 550 555 560Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn
Val Ile Leu Phe 565 570 575Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr
Leu Thr Glu Asn Ile Gln 580 585 590Arg Phe Leu Pro Asn Pro Ala Gly
Val Gln Leu Glu Asp Pro Glu Phe 595 600 605Gln Ala Ser Asn Ile Met
His Ser Ile Asn Gly Tyr Val Phe Asp Ser 610 615 620Leu Gln Leu Ser
Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu625 630 635 640Ser
Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 645 650
655Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro
660 665 670Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly
Leu Trp 675 680 685Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg
Gly Met Thr Ala 690 695 700Leu Leu Lys Val Ser Ser Cys Asp Lys Asn
Thr Gly Asp Tyr Tyr Glu705 710 715 720Asp Ser Tyr Glu Asp Ile Ser
Ala Tyr Leu Leu Ser Lys Asn Asn Ala 725 730 735Ile Glu Pro Arg Ser
Phe Ser Gln Asn Gly Gly Gly Gly Ser Thr Gly 740 745 750Gly Thr Gly
Gly Ser Ser Gly Gly Gly Thr Gly Ser Gly Gly Gly Gly 755 760 765Thr
Gly Gly Ser Gly Gly Thr Asp Ile Gln Leu Thr Gln Ser Pro Ser 770 775
780Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg
Ala785 790 795 800Ser Ser Ser Val Arg Tyr Ile Tyr Trp Phe Gln Gln
Lys Pro Gly Lys 805 810 815Ala Pro Lys Leu Leu Ile Tyr Ala Thr Ser
Phe Leu Gln Ser Gly Val 820 825 830Pro Ser Arg Phe Ser Gly Ser Gly
Ser Gly Thr Glu Tyr Thr Leu Thr 835 840 845Ile Ser Ser Leu Gln Pro
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln 850 855 860Arg Asn Ser Phe
Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile865 870 875 880Lys
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 885 890
895Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val
900 905 910Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser
Gly Tyr 915 920 925Thr Phe Thr Thr Tyr Ala Ile His Trp Val Arg Gln
Ala Pro Gly Gln 930 935 940Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro
Ser Ser Gly Tyr Thr Arg945 950 955 960Tyr Asn Pro Lys Phe Lys His
Arg Val Thr Met Thr Arg Asp Lys Ser 965 970 975Thr Ser Thr Ala Tyr
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr 980 985 990Ala Val Tyr
Tyr Cys Trp Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly 995 1000
1005Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Asn Pro
1010 1015 1020Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Asp Glu
Asn Gln 1025 1030 1035Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His
Tyr Phe Ile Ala 1040 1045 1050Ala Val Glu Arg Leu Trp Asp Tyr Gly
Met Ser Ser Ser Pro His 1055 1060 1065Val Leu Arg Asn Arg Ala Gln
Ser Gly Ser Val Pro Gln Phe Lys 1070 1075 1080Lys Val Val Phe Gln
Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro 1085 1090 1095Leu Tyr Arg
Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro 1100 1105 1110Tyr
Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg 1115 1120
1125Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser
1130 1135 1140Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys
Asn Phe 1145 1150 1155Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp
Lys Val Gln His 1160 1165 1170His Met Ala Pro Thr Lys Asp Glu Phe
Asp Cys Lys Ala Trp Ala 1175 1180 1185Tyr Phe Ser Asp Val Asp Leu
Glu Lys Asp Val His Ser Gly Leu 1190 1195 1200Ile Gly Pro Leu Leu
Val Cys His Thr Asn Thr Leu Asn Pro Ala 1205 1210 1215His Gly Arg
Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr 1220 1225 1230Ile
Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu 1235 1240
1245Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr
1250 1255 1260Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr
Ile Met 1265 1270 1275Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp
Gln Arg Ile Arg 1280 1285 1290Trp Tyr Leu Leu Ser Met Gly Ser Asn
Glu Asn Ile His Ser Ile 1295 1300 1305His Phe Ser Gly His Val Phe
Thr Val Arg Lys Lys Glu Glu Tyr 1310 1315 1320Lys Met Ala Leu Tyr
Asn Leu Tyr Pro Gly Val Phe Glu Thr Val 1325 1330 1335Glu Met Leu
Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu 1340 1345 1350Ile
Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val 1355 1360
1365Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His
1370 1375 1380Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly
Gln Trp 1385 1390 1395Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly
Ser Ile Asn Ala 1400 1405 1410Trp Ser Thr Lys Glu Pro Phe Ser Trp
Ile Lys Val Asp Leu Leu 1415 1420 1425Ala Pro Met Ile Ile His Gly
Ile Lys Thr Gln Gly Ala Arg Gln 1430 1435 1440Lys Phe Ser Ser Leu
Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser 1445 1450 1455Leu Asp Gly
Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly 1460 1465 1470Thr
Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys 1475 1480
1485His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu
1490 1495 1500His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met
Glu Leu 1505 1510 1515Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro
Leu Gly Met Glu 1520 1525 1530Ser Lys Ala Ile Ser Asp Ala Gln Ile
Thr Ala Ser Ser Tyr Phe 1535 1540 1545Thr Asn Met Phe Ala Thr Trp
Ser Pro Ser Lys Ala Arg Leu His 1550 1555 1560Leu Gln Gly Arg Ser
Asn Ala Trp Arg Pro Gln Val Asn Asn Pro 1565 1570 1575Lys Glu Trp
Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr 1580 1585 1590Gly
Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr 1595 1600
1605Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp
1610 1615 1620Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln
Gly Asn 1625 1630 1635Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu
Asp Pro Pro Leu 1640 1645 1650Leu Thr Arg Tyr Leu Arg Ile His Pro
Gln Ser Trp Val His Gln 1655 1660 1665Ile Ala Leu Arg Met Glu Val
Leu Gly Cys Glu Ala Gln Asp Leu 1670 1675
1680Tyr1171684PRTArtificial SequenceSynthetic Sequence 117Ala Thr
Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1 5 10 15Met
Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25
30Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys
35 40 45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys
Pro 50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala
Glu Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala
Ser His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys
Ala Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser Gln Arg
Glu Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser His Thr
Tyr Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met Ala Ser
Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155 160His Val
Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170
175Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu
180 185 190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys
Ser Trp 195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg
Asp Ala Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His Thr Val
Asn Gly Tyr Val Asn Arg225 230 235 240Ser Leu Pro Gly Leu Ile Gly
Cys His Arg Lys Ser Val Tyr Trp His 245 250 255Val Ile Gly Met Gly
Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270Gly His Thr
Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285Ser
Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295
300Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly
Met305 310 315 320Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu
Pro Gln Leu Arg 325 330 335Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr
Asp Asp Asp Leu Thr Asp 340 345 350Ser Glu Met Asp Val Val Arg Phe
Asp Asp Asp Asn Ser Pro Ser Phe 355 360 365Ile Gln Ile Arg Ser Val
Ala Lys Lys His Pro Lys Thr Trp Val His 370 375 380Tyr Ile Ala Ala
Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu385 390 395 400Ala
Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410
415Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr
420 425 430Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser
Gly Ile 435 440 445Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr
Leu Leu Ile Ile 450 455 460Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn
Ile Tyr Pro His Gly Ile465 470 475 480Thr Asp Val Arg Pro Leu Tyr
Ser Arg Arg Leu Pro Lys Gly Val Lys 485 490 495His Leu Lys Asp Phe
Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510Trp Thr Val
Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525Leu
Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535
540Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val
Asp545 550 555 560Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn
Val Ile Leu Phe 565 570 575Ser Val Phe Asp
Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 580 585 590Arg Phe
Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 595 600
605Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser
610 615 620Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr
Ile Leu625 630 635 640Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val
Phe Phe Ser Gly Tyr 645 650 655Thr Phe Lys His Lys Met Val Tyr Glu
Asp Thr Leu Thr Leu Phe Pro 660 665 670Phe Ser Gly Glu Thr Val Phe
Met Ser Met Glu Asn Pro Gly Leu Trp 675 680 685Ile Leu Gly Cys His
Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 690 695 700Leu Leu Lys
Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu705 710 715
720Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala
725 730 735Ile Glu Pro Arg Ser Phe Ser Gln Asn Gly Gly Gly Gly Ser
Thr Gly 740 745 750Gly Thr Gly Gly Ser Ser Gly Gly Gly Thr Gly Ser
Gly Gly Gly Gly 755 760 765Thr Gly Gly Ser Gly Gly Thr Asp Ile Gln
Leu Thr Gln Ser Pro Ser 770 775 780Phe Leu Ser Ala Ser Val Gly Asp
Arg Val Thr Ile Thr Cys Arg Ala785 790 795 800Ser Ser Ser Val Ser
Tyr Ile Tyr Trp Phe Gln Gln Lys Pro Gly Lys 805 810 815Ala Pro Lys
Leu Leu Ile Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val 820 825 830Pro
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr 835 840
845Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln
850 855 860Arg Asn Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu
Glu Ile865 870 875 880Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 885 890 895Gly Gly Gly Gly Ser Glu Val Gln Leu
Val Gln Ser Gly Ala Glu Val 900 905 910Lys Lys Pro Gly Ala Ser Val
Lys Val Ser Cys Lys Ala Ser Gly Tyr 915 920 925Thr Phe Thr Arg Tyr
Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln 930 935 940Gly Leu Glu
Trp Met Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg945 950 955
960Tyr Asn Pro Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser
965 970 975Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp
Asp Thr 980 985 990Ala Val Tyr Tyr Cys Trp Thr Gly Thr Arg Asp Tyr
Trp Gly Gln Gly 995 1000 1005Thr Thr Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gln Asn Pro 1010 1015 1020Pro Val Leu Lys Arg His Gln
Arg Glu Ile Thr Asp Glu Asn Gln 1025 1030 1035Ser Pro Arg Ser Phe
Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 1040 1045 1050Ala Val Glu
Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His 1055 1060 1065Val
Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys 1070 1075
1080Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro
1085 1090 1095Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu
Gly Pro 1100 1105 1110Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met
Val Thr Phe Arg 1115 1120 1125Asn Gln Ala Ser Arg Pro Tyr Ser Phe
Tyr Ser Ser Leu Ile Ser 1130 1135 1140Tyr Glu Glu Asp Gln Arg Gln
Gly Ala Glu Pro Arg Lys Asn Phe 1145 1150 1155Val Lys Pro Asn Glu
Thr Lys Thr Tyr Phe Trp Lys Val Gln His 1160 1165 1170His Met Ala
Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala 1175 1180 1185Tyr
Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 1190 1195
1200Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala
1205 1210 1215His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe
Phe Thr 1220 1225 1230Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr
Glu Asn Met Glu 1235 1240 1245Arg Asn Cys Arg Ala Pro Cys Asn Ile
Gln Met Glu Asp Pro Thr 1250 1255 1260Phe Lys Glu Asn Tyr Arg Phe
His Ala Ile Asn Gly Tyr Ile Met 1265 1270 1275Asp Thr Leu Pro Gly
Leu Val Met Ala Gln Asp Gln Arg Ile Arg 1280 1285 1290Trp Tyr Leu
Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile 1295 1300 1305His
Phe Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr 1310 1315
1320Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val
1325 1330 1335Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu
Cys Leu 1340 1345 1350Ile Gly Glu His Leu His Ala Gly Met Ser Thr
Leu Phe Leu Val 1355 1360 1365Tyr Ser Asn Lys Cys Gln Thr Pro Leu
Gly Met Ala Ser Gly His 1370 1375 1380Ile Arg Asp Phe Gln Ile Thr
Ala Ser Gly Gln Tyr Gly Gln Trp 1385 1390 1395Ala Pro Lys Leu Ala
Arg Leu His Tyr Ser Gly Ser Ile Asn Ala 1400 1405 1410Trp Ser Thr
Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu 1415 1420 1425Ala
Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln 1430 1435
1440Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser
1445 1450 1455Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser
Thr Gly 1460 1465 1470Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser
Ser Gly Ile Lys 1475 1480 1485His Asn Ile Phe Asn Pro Pro Ile Ile
Ala Arg Tyr Ile Arg Leu 1490 1495 1500His Pro Thr His Tyr Ser Ile
Arg Ser Thr Leu Arg Met Glu Leu 1505 1510 1515Met Gly Cys Asp Leu
Asn Ser Cys Ser Met Pro Leu Gly Met Glu 1520 1525 1530Ser Lys Ala
Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe 1535 1540 1545Thr
Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His 1550 1555
1560Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro
1565 1570 1575Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys
Val Thr 1580 1585 1590Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu
Thr Ser Met Tyr 1595 1600 1605Val Lys Glu Phe Leu Ile Ser Ser Ser
Gln Asp Gly His Gln Trp 1610 1615 1620Thr Leu Phe Phe Gln Asn Gly
Lys Val Lys Val Phe Gln Gly Asn 1625 1630 1635Gln Asp Ser Phe Thr
Pro Val Val Asn Ser Leu Asp Pro Pro Leu 1640 1645 1650Leu Thr Arg
Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln 1655 1660 1665Ile
Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu 1670 1675
1680Tyr1181715PRTArtificial SequenceSynthetic Sequence 118Ala Thr
Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1 5 10 15Met
Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25
30Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys
35 40 45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys
Pro 50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala
Glu Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala
Ser His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys
Ala Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser Gln Arg
Glu Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser His Thr
Tyr Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met Ala Ser
Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155 160His Val
Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170
175Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu
180 185 190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys
Ser Trp 195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg
Asp Ala Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His Thr Val
Asn Gly Tyr Val Asn Arg225 230 235 240Ser Leu Pro Gly Leu Ile Gly
Cys His Arg Lys Ser Val Tyr Trp His 245 250 255Val Ile Gly Met Gly
Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270Gly His Thr
Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285Ser
Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295
300Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly
Met305 310 315 320Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu
Pro Gln Leu Arg 325 330 335Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr
Asp Asp Asp Leu Thr Asp 340 345 350Ser Glu Met Asp Val Val Arg Phe
Asp Asp Asp Asn Ser Pro Ser Phe 355 360 365Ile Gln Ile Arg Ser Val
Ala Lys Lys His Pro Lys Thr Trp Val His 370 375 380Tyr Ile Ala Ala
Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu385 390 395 400Ala
Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410
415Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr
420 425 430Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser
Gly Ile 435 440 445Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr
Leu Leu Ile Ile 450 455 460Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn
Ile Tyr Pro His Gly Ile465 470 475 480Thr Asp Val Arg Pro Leu Tyr
Ser Arg Arg Leu Pro Lys Gly Val Lys 485 490 495His Leu Lys Asp Phe
Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510Trp Thr Val
Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525Leu
Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535
540Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val
Asp545 550 555 560Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn
Val Ile Leu Phe 565 570 575Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr
Leu Thr Glu Asn Ile Gln 580 585 590Arg Phe Leu Pro Asn Pro Ala Gly
Val Gln Leu Glu Asp Pro Glu Phe 595 600 605Gln Ala Ser Asn Ile Met
His Ser Ile Asn Gly Tyr Val Phe Asp Ser 610 615 620Leu Gln Leu Ser
Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu625 630 635 640Ser
Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 645 650
655Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro
660 665 670Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly
Leu Trp 675 680 685Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg
Gly Met Thr Ala 690 695 700Leu Leu Lys Val Ser Ser Cys Asp Lys Asn
Thr Gly Asp Tyr Tyr Glu705 710 715 720Asp Ser Tyr Glu Asp Ile Ser
Ala Tyr Leu Leu Ser Lys Asn Asn Ala 725 730 735Ile Glu Pro Arg Ser
Phe Ser Gln Asn Gly Gly Gly Gly Ser Thr Gly 740 745 750Gly Thr Gly
Gly Ser Ser Gly Gly Gly Thr Gly Ser Gly Gly Gly Gly 755 760 765Thr
Gly Gly Ser Gly Gly Thr Asp Ile Gln Leu Thr Gln Ser Pro Ser 770 775
780Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg
Ala785 790 795 800Ser Ser Ser Val Arg Tyr Ile Tyr Trp Phe Gln Gln
Lys Pro Gly Lys 805 810 815Ala Pro Lys Leu Leu Ile Tyr Ala Thr Ser
Phe Arg Gln Ser Gly Val 820 825 830Pro Ser Arg Phe Ser Gly Ser Gly
Ser Gly Thr Glu Tyr Thr Leu Thr 835 840 845Ile Ser Ser Leu Gln Pro
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln 850 855 860Arg Asn Ser Phe
Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile865 870 875 880Lys
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 885 890
895Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val
900 905 910Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser
Gly Tyr 915 920 925Thr Phe Thr Thr Tyr Ala Ile His Trp Val Arg Gln
Ala Pro Gly Gln 930 935 940Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro
Ser Ser Gly Tyr Thr Arg945 950 955 960Tyr Asn Pro Lys Phe Lys Gly
Arg Val Thr Met Thr Arg Asp Lys Ser 965 970 975Thr Ser Thr Ala Tyr
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr 980 985 990Ala Val Tyr
Tyr Cys Trp Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly 995 1000
1005Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Asn Pro
1010 1015 1020Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr
Thr Leu 1025 1030 1035Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp
Thr Ile Ser Val 1040 1045 1050Glu Met Lys Lys Glu Asp Phe Asp Ile
Tyr Asp Glu Asp Glu Asn 1055 1060 1065Gln Ser Pro Arg Ser Phe Gln
Lys Lys Thr Arg His Tyr Phe Ile 1070 1075 1080Ala Ala Val Glu Arg
Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro 1085 1090 1095His Val Leu
Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe 1100 1105 1110Lys
Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln 1115 1120
1125Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly
1130 1135 1140Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val
Thr Phe 1145 1150 1155Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr
Ser Ser Leu Ile 1160 1165 1170Ser Tyr Glu Glu Asp Gln Arg Gln Gly
Ala Glu Pro Arg Lys Asn 1175 1180 1185Phe Val Lys Pro Asn Glu Thr
Lys Thr Tyr Phe Trp Lys Val Gln 1190 1195 1200His His Met Ala Pro
Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 1205 1210 1215Ala Tyr Phe
Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly 1220 1225 1230Leu
Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro 1235 1240
1245Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe
1250 1255 1260Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu
Asn Met 1265 1270 1275Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln
Met Glu Asp Pro 1280 1285 1290Thr Phe Lys Glu Asn Tyr Arg Phe His
Ala Ile Asn Gly Tyr Ile 1295 1300 1305Met Asp Thr Leu Pro Gly Leu
Val Met Ala Gln Asp Gln Arg Ile 1310 1315 1320Arg Trp Tyr Leu Leu
Ser Met Gly Ser Asn Glu Asn Ile His Ser 1325 1330 1335Ile His Phe
Ser Gly His Val Phe Thr Val Arg Lys Lys
Glu Glu 1340 1345 1350Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly
Val Phe Glu Thr 1355 1360 1365Val Glu Met Leu Pro Ser Lys Ala Gly
Ile Trp Arg Val Glu Cys 1370 1375 1380Leu Ile Gly Glu His Leu His
Ala Gly Met Ser Thr Leu Phe Leu 1385 1390 1395Val Tyr Ser Asn Lys
Cys Gln Thr Pro Leu Gly Met Ala Ser Gly 1400 1405 1410His Ile Arg
Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln 1415 1420 1425Trp
Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn 1430 1435
1440Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu
1445 1450 1455Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly
Ala Arg 1460 1465 1470Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe
Ile Ile Met Tyr 1475 1480 1485Ser Leu Asp Gly Lys Lys Trp Gln Thr
Tyr Arg Gly Asn Ser Thr 1490 1495 1500Gly Thr Leu Met Val Phe Phe
Gly Asn Val Asp Ser Ser Gly Ile 1505 1510 1515Lys His Asn Ile Phe
Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg 1520 1525 1530Leu His Pro
Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu 1535 1540 1545Leu
Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met 1550 1555
1560Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr
1565 1570 1575Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala
Arg Leu 1580 1585 1590His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro
Gln Val Asn Asn 1595 1600 1605Pro Lys Glu Trp Leu Gln Val Asp Phe
Gln Lys Thr Met Lys Val 1610 1615 1620Thr Gly Val Thr Thr Gln Gly
Val Lys Ser Leu Leu Thr Ser Met 1625 1630 1635Tyr Val Lys Glu Phe
Leu Ile Ser Ser Ser Gln Asp Gly His Gln 1640 1645 1650Trp Thr Leu
Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly 1655 1660 1665Asn
Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro 1670 1675
1680Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His
1685 1690 1695Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala
Gln Asp 1700 1705 1710Leu Tyr 17151191704PRTArtificial
SequenceSynthetic Sequence 119Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Ser Ser Val Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ala Thr Ser Phe Arg Gln
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu
Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 100 105
110Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val
115 120 125Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
Ser Val 130 135 140Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
Thr Tyr Ala Ile145 150 155 160His Trp Val Arg Gln Ala Pro Gly Gln
Gly Leu Glu Trp Met Gly Tyr 165 170 175Ile Asn Pro Ser Ser Gly Tyr
Thr Arg Tyr Asn Pro Lys Phe Lys Gly 180 185 190Arg Val Thr Met Thr
Arg Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 195 200 205Leu Arg Ser
Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Trp Thr 210 215 220Gly
Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser225 230
235 240Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Leu Val Pro Arg Gly
Ser 245 250 255Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Thr Arg
Arg Tyr Tyr 260 265 270Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr Met
Gln Ser Asp Leu Gly 275 280 285Glu Leu Pro Val Asp Ala Arg Phe Pro
Pro Arg Val Pro Lys Ser Phe 290 295 300Pro Phe Asn Thr Ser Val Val
Tyr Lys Lys Thr Leu Phe Val Glu Phe305 310 315 320Thr Asp His Leu
Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly 325 330 335Leu Leu
Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile 340 345
350Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala Val Gly
355 360 365Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp
Gln Thr 370 375 380Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro
Gly Gly Ser His385 390 395 400Thr Tyr Val Trp Gln Val Leu Lys Glu
Asn Gly Pro Met Ala Ser Asp 405 410 415Pro Leu Cys Leu Thr Tyr Ser
Tyr Leu Ser His Val Asp Leu Val Lys 420 425 430Asp Leu Asn Ser Gly
Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly 435 440 445Ser Leu Ala
Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu 450 455 460Phe
Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn465 470
475 480Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro
Lys 485 490 495Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro
Gly Leu Ile 500 505 510Gly Cys His Arg Lys Ser Val Tyr Trp His Val
Ile Gly Met Gly Thr 515 520 525Thr Pro Glu Val His Ser Ile Phe Leu
Glu Gly His Thr Phe Leu Val 530 535 540Arg Asn His Arg Gln Ala Ser
Leu Glu Ile Ser Pro Ile Thr Phe Leu545 550 555 560Thr Ala Gln Thr
Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys 565 570 575His Ile
Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val 580 585
590Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu
595 600 605Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp
Val Val 610 615 620Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln
Ile Arg Ser Val625 630 635 640Ala Lys Lys His Pro Lys Thr Trp Val
His Tyr Ile Ala Ala Glu Glu 645 650 655Glu Asp Trp Asp Tyr Ala Pro
Leu Val Leu Ala Pro Asp Asp Arg Ser 660 665 670Tyr Lys Ser Gln Tyr
Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys 675 680 685Tyr Lys Lys
Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr 690 695 700Arg
Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr705 710
715 720Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala
Ser 725 730 735Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val
Arg Pro Leu 740 745 750Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His
Leu Lys Asp Phe Pro 755 760 765Ile Leu Pro Gly Glu Ile Phe Lys Tyr
Lys Trp Thr Val Thr Val Glu 770 775 780Asp Gly Pro Thr Lys Ser Asp
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser785 790 795 800Ser Phe Val Asn
Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro 805 810 815Leu Leu
Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile 820 825
830Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn
835 840 845Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro
Asn Pro 850 855 860Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala
Ser Asn Ile Met865 870 875 880His Ser Ile Asn Gly Tyr Val Phe Asp
Ser Leu Gln Leu Ser Val Cys 885 890 895Leu His Glu Val Ala Tyr Trp
Tyr Ile Leu Ser Ile Gly Ala Gln Thr 900 905 910Asp Phe Leu Ser Val
Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met 915 920 925Val Tyr Glu
Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val 930 935 940Phe
Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn945 950
955 960Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser
Ser 965 970 975Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr
Glu Asp Ile 980 985 990Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile
Glu Pro Arg Ser Phe 995 1000 1005Ser Gln Asn Pro Pro Val Leu Lys
Arg His Gln Arg Glu Ile Thr 1010 1015 1020Arg Thr Thr Leu Gln Ser
Asp Gln Glu Glu Ile Asp Tyr Asp Asp 1025 1030 1035Thr Ile Ser Val
Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp 1040 1045 1050Glu Asp
Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg 1055 1060
1065His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met
1070 1075 1080Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser
Gly Ser 1085 1090 1095Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu
Phe Thr Asp Gly 1100 1105 1110Ser Phe Thr Gln Pro Leu Tyr Arg Gly
Glu Leu Asn Glu His Leu 1115 1120 1125Gly Leu Leu Gly Pro Tyr Ile
Arg Ala Glu Val Glu Asp Asn Ile 1130 1135 1140Met Val Thr Phe Arg
Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr 1145 1150 1155Ser Ser Leu
Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu 1160 1165 1170Pro
Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe 1175 1180
1185Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp
1190 1195 1200Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu
Lys Asp 1205 1210 1215Val His Ser Gly Leu Ile Gly Pro Leu Leu Val
Cys His Thr Asn 1220 1225 1230Thr Leu Asn Pro Ala His Gly Arg Gln
Val Thr Val Gln Glu Phe 1235 1240 1245Ala Leu Phe Phe Thr Ile Phe
Asp Glu Thr Lys Ser Trp Tyr Phe 1250 1255 1260Thr Glu Asn Met Glu
Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln 1265 1270 1275Met Glu Asp
Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile 1280 1285 1290Asn
Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln 1295 1300
1305Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu
1310 1315 1320Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr
Val Arg 1325 1330 1335Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn
Leu Tyr Pro Gly 1340 1345 1350Val Phe Glu Thr Val Glu Met Leu Pro
Ser Lys Ala Gly Ile Trp 1355 1360 1365Arg Val Glu Cys Leu Ile Gly
Glu His Leu His Ala Gly Met Ser 1370 1375 1380Thr Leu Phe Leu Val
Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly 1385 1390 1395Met Ala Ser
Gly His Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly 1400 1405 1410Gln
Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr Ser 1415 1420
1425Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile
1430 1435 1440Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile
Lys Thr 1445 1450 1455Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr
Ile Ser Gln Phe 1460 1465 1470Ile Ile Met Tyr Ser Leu Asp Gly Lys
Lys Trp Gln Thr Tyr Arg 1475 1480 1485Gly Asn Ser Thr Gly Thr Leu
Met Val Phe Phe Gly Asn Val Asp 1490 1495 1500Ser Ser Gly Ile Lys
His Asn Ile Phe Asn Pro Pro Ile Ile Ala 1505 1510 1515Arg Tyr Ile
Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr 1520 1525 1530Leu
Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met 1535 1540
1545Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr
1550 1555 1560Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser
Pro Ser 1565 1570 1575Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn
Ala Trp Arg Pro 1580 1585 1590Gln Val Asn Asn Pro Lys Glu Trp Leu
Gln Val Asp Phe Gln Lys 1595 1600 1605Thr Met Lys Val Thr Gly Val
Thr Thr Gln Gly Val Lys Ser Leu 1610 1615 1620Leu Thr Ser Met Tyr
Val Lys Glu Phe Leu Ile Ser Ser Ser Gln 1625 1630 1635Asp Gly His
Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys 1640 1645 1650Val
Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser 1655 1660
1665Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln
1670 1675 1680Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu
Gly Cys 1685 1690 1695Glu Ala Gln Asp Leu Tyr
17001201704PRTArtificial SequenceSynthetic Sequence 120Ala Thr Arg
Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1 5 10 15Met Gln
Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25 30Arg
Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 35 40
45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro
50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu
Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser
His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala
Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu
Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser His Thr Tyr
Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met Ala Ser Asp
Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155 160His Val Asp
Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170 175Leu
Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 180 185
190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp
195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala
Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly
Tyr Val Asn Arg225 230 235 240Ser Leu Pro Gly Leu Ile Gly Cys His
Arg Lys Ser Val Tyr Trp His 245 250 255Val Ile Gly Met Gly Thr Thr
Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270Gly His Thr Phe Leu
Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285Ser Pro Ile
Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295 300Gln
Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met305 310
315 320Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu
Arg 325 330 335Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp
Leu Thr Asp 340 345 350Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp
Asn Ser Pro Ser Phe 355 360 365Ile Gln Ile Arg Ser Val Ala
Lys Lys His Pro Lys Thr Trp Val His 370 375 380Tyr Ile Ala Ala Glu
Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu385 390 395 400Ala Pro
Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410
415Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr
420 425 430Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser
Gly Ile 435 440 445Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr
Leu Leu Ile Ile 450 455 460Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn
Ile Tyr Pro His Gly Ile465 470 475 480Thr Asp Val Arg Pro Leu Tyr
Ser Arg Arg Leu Pro Lys Gly Val Lys 485 490 495His Leu Lys Asp Phe
Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510Trp Thr Val
Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525Leu
Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535
540Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val
Asp545 550 555 560Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn
Val Ile Leu Phe 565 570 575Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr
Leu Thr Glu Asn Ile Gln 580 585 590Arg Phe Leu Pro Asn Pro Ala Gly
Val Gln Leu Glu Asp Pro Glu Phe 595 600 605Gln Ala Ser Asn Ile Met
His Ser Ile Asn Gly Tyr Val Phe Asp Ser 610 615 620Leu Gln Leu Ser
Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu625 630 635 640Ser
Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 645 650
655Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro
660 665 670Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly
Leu Trp 675 680 685Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg
Gly Met Thr Ala 690 695 700Leu Leu Lys Val Ser Ser Cys Asp Lys Asn
Thr Gly Asp Tyr Tyr Glu705 710 715 720Asp Ser Tyr Glu Asp Ile Ser
Ala Tyr Leu Leu Ser Lys Asn Asn Ala 725 730 735Ile Glu Pro Arg Ser
Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 740 745 750Gln Arg Glu
Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 755 760 765Asp
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 770 775
780Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys
Lys785 790 795 800Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu
Trp Asp Tyr Gly 805 810 815Met Ser Ser Ser Pro His Val Leu Arg Asn
Arg Ala Gln Ser Gly Ser 820 825 830Val Pro Gln Phe Lys Lys Val Val
Phe Gln Glu Phe Thr Asp Gly Ser 835 840 845Phe Thr Gln Pro Leu Tyr
Arg Gly Glu Leu Asn Glu His Leu Gly Leu 850 855 860Leu Gly Pro Tyr
Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr865 870 875 880Phe
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 885 890
895Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe
900 905 910Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln
His His 915 920 925Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala
Trp Ala Tyr Phe 930 935 940Ser Asp Val Asp Leu Glu Lys Asp Val His
Ser Gly Leu Ile Gly Pro945 950 955 960Leu Leu Val Cys His Thr Asn
Thr Leu Asn Pro Ala His Gly Arg Gln 965 970 975Val Thr Val Gln Glu
Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 980 985 990Lys Ser Trp
Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro 995 1000
1005Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg
1010 1015 1020Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro
Gly Leu 1025 1030 1035Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr
Leu Leu Ser Met 1040 1045 1050Gly Ser Asn Glu Asn Ile His Ser Ile
His Phe Ser Gly His Val 1055 1060 1065Phe Thr Val Arg Lys Lys Glu
Glu Tyr Lys Met Ala Leu Tyr Asn 1070 1075 1080Leu Tyr Pro Gly Val
Phe Glu Thr Val Glu Met Leu Pro Ser Lys 1085 1090 1095Ala Gly Ile
Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His 1100 1105 1110Ala
Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln 1115 1120
1125Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile
1130 1135 1140Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu
Ala Arg 1145 1150 1155Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser
Thr Lys Glu Pro 1160 1165 1170Phe Ser Trp Ile Lys Val Asp Leu Leu
Ala Pro Met Ile Ile His 1175 1180 1185Gly Ile Lys Thr Gln Gly Ala
Arg Gln Lys Phe Ser Ser Leu Tyr 1190 1195 1200Ile Ser Gln Phe Ile
Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp 1205 1210 1215Gln Thr Tyr
Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 1220 1225 1230Gly
Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro 1235 1240
1245Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser
1250 1255 1260Ile Arg Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp
Leu Asn 1265 1270 1275Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys
Ala Ile Ser Asp 1280 1285 1290Ala Gln Ile Thr Ala Ser Ser Tyr Phe
Thr Asn Met Phe Ala Thr 1295 1300 1305Trp Ser Pro Ser Lys Ala Arg
Leu His Leu Gln Gly Arg Ser Asn 1310 1315 1320Ala Trp Arg Pro Gln
Val Asn Asn Pro Lys Glu Trp Leu Gln Val 1325 1330 1335Asp Phe Gln
Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly 1340 1345 1350Val
Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile 1355 1360
1365Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn
1370 1375 1380Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe
Thr Pro 1385 1390 1395Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr
Arg Tyr Leu Arg 1400 1405 1410Ile His Pro Gln Ser Trp Val His Gln
Ile Ala Leu Arg Met Glu 1415 1420 1425Val Leu Gly Cys Glu Ala Gln
Asp Leu Tyr Gly Gly Gly Ser Gly 1430 1435 1440Gly Gly Gly Ser Gly
Leu Val Pro Arg Gly Ser Gly Gly Gly Ser 1445 1450 1455Gly Gly Gly
Gly Ser Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser 1460 1465 1470Phe
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 1475 1480
1485Ala Ser Ser Ser Val Arg Tyr Ile Tyr Trp Phe Gln Gln Lys Pro
1490 1495 1500Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Thr Ser Phe
Arg Gln 1505 1510 1515Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
Ser Gly Thr Glu 1520 1525 1530Tyr Thr Leu Thr Ile Ser Ser Leu Gln
Pro Glu Asp Phe Ala Thr 1535 1540 1545Tyr Tyr Cys His Gln Arg Asn
Ser Phe Pro Tyr Thr Phe Gly Gln 1550 1555 1560Gly Thr Lys Leu Glu
Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 1565 1570 1575Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 1580 1585 1590Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 1595 1600
1605Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Ala
1610 1615 1620Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 1625 1630 1635Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg
Tyr Asn Pro Lys 1640 1645 1650Phe Lys Gly Arg Val Thr Met Thr Arg
Asp Lys Ser Thr Ser Thr 1655 1660 1665Ala Tyr Met Glu Leu Arg Ser
Leu Arg Ser Asp Asp Thr Ala Val 1670 1675 1680Tyr Tyr Cys Trp Thr
Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr 1685 1690 1695Thr Val Thr
Val Ser Ser 17001211661PRTArtificial SequenceSynthetic Sequence
121Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1
5 10 15Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro
Pro 20 25 30Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr
Lys Lys 35 40 45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile
Ala Lys Pro 50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile
Gln Ala Glu Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn
Met Ala Ser His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr
Trp Lys Ala Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser
Gln Arg Glu Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser
His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met
Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155
160His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu
165 170 175Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln
Thr Leu 180 185 190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu
Gly Lys Ser Trp 195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln
Asp Arg Asp Ala Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His
Thr Val Asn Gly Tyr Val Asn Arg225 230 235 240Ser Leu Pro Gly Leu
Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 245 250 255Val Ile Gly
Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270Gly
His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280
285Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly
290 295 300Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp
Gly Met305 310 315 320Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu
Glu Pro Gln Leu Arg 325 330 335Met Lys Asn Asn Glu Glu Ala Glu Asp
Tyr Asp Asp Asp Leu Thr Asp 340 345 350Ser Glu Met Asp Val Val Arg
Phe Asp Asp Asp Asn Ser Pro Ser Phe 355 360 365Ile Gln Ile Arg Ser
Val Ala Lys Lys His Pro Lys Thr Trp Val His 370 375 380Tyr Ile Ala
Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu385 390 395
400Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro
405 410 415Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala
Tyr Thr 420 425 430Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His
Glu Ser Gly Ile 435 440 445Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly
Asp Thr Leu Leu Ile Ile 450 455 460Phe Lys Asn Gln Ala Ser Arg Pro
Tyr Asn Ile Tyr Pro His Gly Ile465 470 475 480Thr Asp Val Arg Pro
Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 485 490 495His Leu Lys
Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510Trp
Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520
525Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala
530 535 540Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser
Val Asp545 550 555 560Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg
Asn Val Ile Leu Phe 565 570 575Ser Val Phe Asp Glu Asn Arg Ser Trp
Tyr Leu Thr Glu Asn Ile Gln 580 585 590Arg Phe Leu Pro Asn Pro Ala
Gly Val Gln Leu Glu Asp Pro Glu Phe 595 600 605Gln Ala Ser Asn Ile
Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 610 615 620Leu Gln Leu
Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu625 630 635
640Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr
645 650 655Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu
Phe Pro 660 665 670Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn
Pro Gly Leu Trp 675 680 685Ile Leu Gly Cys His Asn Ser Asp Phe Arg
Asn Arg Gly Met Thr Ala 690 695 700Leu Leu Lys Val Ser Ser Cys Asp
Lys Asn Thr Gly Asp Tyr Tyr Glu705 710 715 720Asp Ser Tyr Glu Asp
Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 725 730 735Ile Glu Pro
Arg Ser Phe Ser Gln Asn Asp Glu Asn Gln Ser Pro Arg 740 745 750Ser
Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg 755 760
765Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg
770 775 780Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe
Gln Glu785 790 795 800Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr
Arg Gly Glu Leu Asn 805 810 815Glu His Leu Gly Leu Leu Gly Pro Tyr
Ile Arg Ala Glu Val Glu Asp 820 825 830Asn Ile Met Val Thr Phe Arg
Asn Gln Ala Ser Arg Pro Tyr Ser Phe 835 840 845Tyr Ser Ser Leu Ile
Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu 850 855 860Pro Arg Lys
Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp865 870 875
880Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys
885 890 895Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val
His Ser 900 905 910Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn
Thr Leu Asn Pro 915 920 925Ala His Gly Arg Gln Val Thr Val Gln Glu
Phe Ala Leu Phe Phe Thr 930 935 940Ile Phe Asp Glu Thr Lys Ser Trp
Tyr Phe Thr Glu Asn Met Glu Arg945 950 955 960Asn Cys Arg Ala Pro
Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys 965 970 975Glu Asn Tyr
Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu 980 985 990Pro
Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu 995
1000 1005Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser
Gly 1010 1015 1020His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys
Met Ala Leu 1025 1030 1035Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr
Val Glu Met Leu Pro 1040 1045 1050Ser Lys Ala Gly Ile Trp Arg Val
Glu Cys Leu Ile Gly Glu His 1055 1060 1065Leu His Ala Gly Met Ser
Thr Leu Phe Leu Val Tyr Ser Asn Lys 1070 1075 1080Cys Gln Thr Pro
Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe 1085 1090 1095Gln Ile
Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu 1100 1105
1110Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys
1115
1120 1125Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met
Ile 1130 1135 1140Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys
Phe Ser Ser 1145 1150 1155Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr
Ser Leu Asp Gly Lys 1160 1165 1170Lys Trp Gln Thr Tyr Arg Gly Asn
Ser Thr Gly Thr Leu Met Val 1175 1180 1185Phe Phe Gly Asn Val Asp
Ser Ser Gly Ile Lys His Asn Ile Phe 1190 1195 1200Asn Pro Pro Ile
Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His 1205 1210 1215Tyr Ser
Ile Arg Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp 1220 1225
1230Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile
1235 1240 1245Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn
Met Phe 1250 1255 1260Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His
Leu Gln Gly Arg 1265 1270 1275Ser Asn Ala Trp Arg Pro Gln Val Asn
Asn Pro Lys Glu Trp Leu 1280 1285 1290Gln Val Asp Phe Gln Lys Thr
Met Lys Val Thr Gly Val Thr Thr 1295 1300 1305Gln Gly Val Lys Ser
Leu Leu Thr Ser Met Tyr Val Lys Glu Phe 1310 1315 1320Leu Ile Ser
Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe 1325 1330 1335Gln
Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe 1340 1345
1350Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr
1355 1360 1365Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala
Leu Arg 1370 1375 1380Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu
Tyr Gly Gly Gly 1385 1390 1395Ser Gly Gly Gly Gly Ser Gly Leu Val
Pro Arg Gly Ser Gly Gly 1400 1405 1410Gly Ser Gly Gly Gly Gly Ser
Gly Asp Ile Gln Leu Thr Gln Ser 1415 1420 1425Pro Ser Phe Leu Ser
Ala Ser Val Gly Asp Arg Val Thr Ile Thr 1430 1435 1440Cys Arg Ala
Ser Ser Ser Val Arg Tyr Ile Tyr Trp Phe Gln Gln 1445 1450 1455Lys
Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Thr Ser Phe 1460 1465
1470Arg Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
1475 1480 1485Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
Asp Phe 1490 1495 1500Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe
Pro Tyr Thr Phe 1505 1510 1515Gly Gln Gly Thr Lys Leu Glu Ile Lys
Gly Gly Gly Gly Ser Gly 1520 1525 1530Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Glu 1535 1540 1545Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1550 1555 1560Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr 1565 1570 1575Tyr
Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 1580 1585
1590Trp Met Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn
1595 1600 1605Pro Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Lys
Ser Thr 1610 1615 1620Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg
Ser Asp Asp Thr 1625 1630 1635Ala Val Tyr Tyr Cys Trp Thr Gly Thr
Arg Asp Tyr Trp Gly Gln 1640 1645 1650Gly Thr Thr Val Thr Val Ser
Ser 1655 16601221673PRTArtificial SequenceSynthetic Sequence 122Ala
Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1 5 10
15Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro
20 25 30Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys
Lys 35 40 45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala
Lys Pro 50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln
Ala Glu Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met
Ala Ser His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr Trp
Lys Ala Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser Gln
Arg Glu Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser His
Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met Ala
Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155 160His
Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170
175Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu
180 185 190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys
Ser Trp 195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg
Asp Ala Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His Thr Val
Asn Gly Tyr Val Asn Arg225 230 235 240Ser Leu Pro Gly Leu Ile Gly
Cys His Arg Lys Ser Val Tyr Trp His 245 250 255Val Ile Gly Met Gly
Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270Gly His Thr
Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285Ser
Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295
300Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly
Met305 310 315 320Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu
Pro Gln Leu Arg 325 330 335Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr
Asp Asp Asp Leu Thr Asp 340 345 350Ser Glu Met Asp Val Val Arg Phe
Asp Asp Asp Asn Ser Pro Ser Phe 355 360 365Ile Gln Ile Arg Ser Val
Ala Lys Lys His Pro Lys Thr Trp Val His 370 375 380Tyr Ile Ala Ala
Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu385 390 395 400Ala
Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410
415Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr
420 425 430Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser
Gly Ile 435 440 445Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr
Leu Leu Ile Ile 450 455 460Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn
Ile Tyr Pro His Gly Ile465 470 475 480Thr Asp Val Arg Pro Leu Tyr
Ser Arg Arg Leu Pro Lys Gly Val Lys 485 490 495His Leu Lys Asp Phe
Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510Trp Thr Val
Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525Leu
Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535
540Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val
Asp545 550 555 560Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn
Val Ile Leu Phe 565 570 575Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr
Leu Thr Glu Asn Ile Gln 580 585 590Arg Phe Leu Pro Asn Pro Ala Gly
Val Gln Leu Glu Asp Pro Glu Phe 595 600 605Gln Ala Ser Asn Ile Met
His Ser Ile Asn Gly Tyr Val Phe Asp Ser 610 615 620Leu Gln Leu Ser
Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu625 630 635 640Ser
Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 645 650
655Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro
660 665 670Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly
Leu Trp 675 680 685Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg
Gly Met Thr Ala 690 695 700Leu Leu Lys Val Ser Ser Cys Asp Lys Asn
Thr Gly Asp Tyr Tyr Glu705 710 715 720Asp Ser Tyr Glu Asp Ile Ser
Ala Tyr Leu Leu Ser Lys Asn Asn Ala 725 730 735Ile Glu Pro Arg Ser
Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 740 745 750Gln Arg Glu
Ile Thr Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys 755 760 765Lys
Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr 770 775
780Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser
Gly785 790 795 800Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu
Phe Thr Asp Gly 805 810 815Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu
Leu Asn Glu His Leu Gly 820 825 830Leu Leu Gly Pro Tyr Ile Arg Ala
Glu Val Glu Asp Asn Ile Met Val 835 840 845Thr Phe Arg Asn Gln Ala
Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu 850 855 860Ile Ser Tyr Glu
Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn865 870 875 880Phe
Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His 885 890
895His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr
900 905 910Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu
Ile Gly 915 920 925Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro
Ala His Gly Arg 930 935 940Gln Val Thr Val Gln Glu Phe Ala Leu Phe
Phe Thr Ile Phe Asp Glu945 950 955 960Thr Lys Ser Trp Tyr Phe Thr
Glu Asn Met Glu Arg Asn Cys Arg Ala 965 970 975Pro Cys Asn Ile Gln
Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg 980 985 990Phe His Ala
Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val 995 1000
1005Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly
1010 1015 1020Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His
Val Phe 1025 1030 1035Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala
Leu Tyr Asn Leu 1040 1045 1050Tyr Pro Gly Val Phe Glu Thr Val Glu
Met Leu Pro Ser Lys Ala 1055 1060 1065Gly Ile Trp Arg Val Glu Cys
Leu Ile Gly Glu His Leu His Ala 1070 1075 1080Gly Met Ser Thr Leu
Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr 1085 1090 1095Pro Leu Gly
Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr 1100 1105 1110Ala
Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu 1115 1120
1125His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe
1130 1135 1140Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile
His Gly 1145 1150 1155Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser
Ser Leu Tyr Ile 1160 1165 1170Ser Gln Phe Ile Ile Met Tyr Ser Leu
Asp Gly Lys Lys Trp Gln 1175 1180 1185Thr Tyr Arg Gly Asn Ser Thr
Gly Thr Leu Met Val Phe Phe Gly 1190 1195 1200Asn Val Asp Ser Ser
Gly Ile Lys His Asn Ile Phe Asn Pro Pro 1205 1210 1215Ile Ile Ala
Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile 1220 1225 1230Arg
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser 1235 1240
1245Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala
1250 1255 1260Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala
Thr Trp 1265 1270 1275Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly
Arg Ser Asn Ala 1280 1285 1290Trp Arg Pro Gln Val Asn Asn Pro Lys
Glu Trp Leu Gln Val Asp 1295 1300 1305Phe Gln Lys Thr Met Lys Val
Thr Gly Val Thr Thr Gln Gly Val 1310 1315 1320Lys Ser Leu Leu Thr
Ser Met Tyr Val Lys Glu Phe Leu Ile Ser 1325 1330 1335Ser Ser Gln
Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly 1340 1345 1350Lys
Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val 1355 1360
1365Val Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile
1370 1375 1380His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met
Glu Val 1385 1390 1395Leu Gly Cys Glu Ala Gln Asp Leu Tyr Gly Gly
Gly Ser Gly Gly 1400 1405 1410Gly Gly Ser Gly Leu Val Pro Arg Gly
Ser Gly Gly Gly Ser Gly 1415 1420 1425Gly Gly Gly Ser Gly Asp Ile
Gln Leu Thr Gln Ser Pro Ser Phe 1430 1435 1440Leu Ser Ala Ser Val
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 1445 1450 1455Ser Ser Ser
Val Arg Tyr Ile Tyr Trp Phe Gln Gln Lys Pro Gly 1460 1465 1470Lys
Ala Pro Lys Leu Leu Ile Tyr Ala Thr Ser Phe Arg Gln Ser 1475 1480
1485Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Tyr
1490 1495 1500Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala
Thr Tyr 1505 1510 1515Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr Thr
Phe Gly Gln Gly 1520 1525 1530Thr Lys Leu Glu Ile Lys Gly Gly Gly
Gly Ser Gly Gly Gly Gly 1535 1540 1545Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Glu Val Gln Leu 1550 1555 1560Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Ala Ser Val Lys 1565 1570 1575Val Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Ala Ile 1580 1585 1590His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 1595 1600
1605Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe
1610 1615 1620Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser
Thr Ala 1625 1630 1635Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr 1640 1645 1650Tyr Cys Trp Thr Gly Thr Arg Asp Tyr
Trp Gly Gln Gly Thr Thr 1655 1660 1665Val Thr Val Ser Ser
16701231669PRTArtificial SequenceSynthetic Sequence 123Ala Thr Arg
Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1 5 10 15Met Gln
Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25 30Arg
Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 35 40
45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro
50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu
Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser
His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala
Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu
Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser His Thr Tyr
Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met Ala Ser Asp
Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155 160His Val Asp
Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170 175Leu
Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 180 185
190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp
195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala
Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly
Tyr Val Asn Arg225
230 235 240Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr
Trp His 245 250 255Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser
Ile Phe Leu Glu 260 265 270Gly His Thr Phe Leu Val Arg Asn His Arg
Gln Ala Ser Leu Glu Ile 275 280 285Ser Pro Ile Thr Phe Leu Thr Ala
Gln Thr Leu Leu Met Asp Leu Gly 290 295 300Gln Phe Leu Leu Phe Cys
His Ile Ser Ser His Gln His Asp Gly Met305 310 315 320Glu Ala Tyr
Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 325 330 335Met
Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 340 345
350Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe
355 360 365Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp
Val His 370 375 380Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala
Pro Leu Val Leu385 390 395 400Ala Pro Asp Asp Arg Ser Tyr Lys Ser
Gln Tyr Leu Asn Asn Gly Pro 405 410 415Gln Arg Ile Gly Arg Lys Tyr
Lys Lys Val Arg Phe Met Ala Tyr Thr 420 425 430Asp Glu Thr Phe Lys
Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 435 440 445Leu Gly Pro
Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 450 455 460Phe
Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile465 470
475 480Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val
Lys 485 490 495His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe
Lys Tyr Lys 500 505 510Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys
Ser Asp Pro Arg Cys 515 520 525Leu Thr Arg Tyr Tyr Ser Ser Phe Val
Asn Met Glu Arg Asp Leu Ala 530 535 540Ser Gly Leu Ile Gly Pro Leu
Leu Ile Cys Tyr Lys Glu Ser Val Asp545 550 555 560Gln Arg Gly Asn
Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 565 570 575Ser Val
Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 580 585
590Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe
595 600 605Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe
Asp Ser 610 615 620Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr
Trp Tyr Ile Leu625 630 635 640Ser Ile Gly Ala Gln Thr Asp Phe Leu
Ser Val Phe Phe Ser Gly Tyr 645 650 655Thr Phe Lys His Lys Met Val
Tyr Glu Asp Thr Leu Thr Leu Phe Pro 660 665 670Phe Ser Gly Glu Thr
Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 675 680 685Ile Leu Gly
Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 690 695 700Leu
Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu705 710
715 720Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn
Ala 725 730 735Ile Glu Pro Arg Ser Phe Ser Gln Asn Gly Gly Gly Gly
Ser Thr Gly 740 745 750Gly Thr Gly Gly Ser Ser Gly Gly Gly Thr Gly
Ser Gly Gly Gly Gly 755 760 765Thr Gly Gly Ser Gly Gly Thr Asp Ile
Gln Leu Thr Gln Ser Pro Ser 770 775 780Phe Leu Ser Ala Ser Val Gly
Asp Arg Val Thr Ile Thr Cys Arg Ala785 790 795 800Ser Ser Ser Val
Arg Tyr Ile Tyr Trp Phe Gln Gln Lys Pro Gly Lys 805 810 815Ala Pro
Lys Leu Leu Ile Tyr Ala Thr Ser Phe Arg Gln Ser Gly Val 820 825
830Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr
835 840 845Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
His Gln 850 855 860Arg Asn Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr
Lys Leu Glu Ile865 870 875 880Lys Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser 885 890 895Gly Gly Gly Gly Ser Glu Val
Gln Leu Val Gln Ser Gly Ala Glu Val 900 905 910Lys Lys Pro Gly Ala
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 915 920 925Thr Phe Thr
Thr Tyr Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln 930 935 940Gly
Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Arg945 950
955 960Tyr Asn Pro Lys Phe Lys Gly Arg Val Thr Met Thr Arg Asp Lys
Ser 965 970 975Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser
Asp Asp Thr 980 985 990Ala Val Tyr Tyr Cys Trp Thr Gly Thr Arg Asp
Tyr Trp Gly Gln Gly 995 1000 1005Thr Thr Val Thr Val Ser Ser Gly
Gly Gly Gly Asp Glu Asn Gln 1010 1015 1020Ser Pro Arg Ser Phe Gln
Lys Lys Thr Arg His Tyr Phe Ile Ala 1025 1030 1035Ala Val Glu Arg
Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His 1040 1045 1050Val Leu
Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys 1055 1060
1065Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro
1070 1075 1080Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu
Gly Pro 1085 1090 1095Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met
Val Thr Phe Arg 1100 1105 1110Asn Gln Ala Ser Arg Pro Tyr Ser Phe
Tyr Ser Ser Leu Ile Ser 1115 1120 1125Tyr Glu Glu Asp Gln Arg Gln
Gly Ala Glu Pro Arg Lys Asn Phe 1130 1135 1140Val Lys Pro Asn Glu
Thr Lys Thr Tyr Phe Trp Lys Val Gln His 1145 1150 1155His Met Ala
Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala 1160 1165 1170Tyr
Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 1175 1180
1185Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala
1190 1195 1200His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe
Phe Thr 1205 1210 1215Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr
Glu Asn Met Glu 1220 1225 1230Arg Asn Cys Arg Ala Pro Cys Asn Ile
Gln Met Glu Asp Pro Thr 1235 1240 1245Phe Lys Glu Asn Tyr Arg Phe
His Ala Ile Asn Gly Tyr Ile Met 1250 1255 1260Asp Thr Leu Pro Gly
Leu Val Met Ala Gln Asp Gln Arg Ile Arg 1265 1270 1275Trp Tyr Leu
Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile 1280 1285 1290His
Phe Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr 1295 1300
1305Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val
1310 1315 1320Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu
Cys Leu 1325 1330 1335Ile Gly Glu His Leu His Ala Gly Met Ser Thr
Leu Phe Leu Val 1340 1345 1350Tyr Ser Asn Lys Cys Gln Thr Pro Leu
Gly Met Ala Ser Gly His 1355 1360 1365Ile Arg Asp Phe Gln Ile Thr
Ala Ser Gly Gln Tyr Gly Gln Trp 1370 1375 1380Ala Pro Lys Leu Ala
Arg Leu His Tyr Ser Gly Ser Ile Asn Ala 1385 1390 1395Trp Ser Thr
Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu 1400 1405 1410Ala
Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln 1415 1420
1425Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser
1430 1435 1440Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser
Thr Gly 1445 1450 1455Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser
Ser Gly Ile Lys 1460 1465 1470His Asn Ile Phe Asn Pro Pro Ile Ile
Ala Arg Tyr Ile Arg Leu 1475 1480 1485His Pro Thr His Tyr Ser Ile
Arg Ser Thr Leu Arg Met Glu Leu 1490 1495 1500Met Gly Cys Asp Leu
Asn Ser Cys Ser Met Pro Leu Gly Met Glu 1505 1510 1515Ser Lys Ala
Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe 1520 1525 1530Thr
Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His 1535 1540
1545Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro
1550 1555 1560Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys
Val Thr 1565 1570 1575Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu
Thr Ser Met Tyr 1580 1585 1590Val Lys Glu Phe Leu Ile Ser Ser Ser
Gln Asp Gly His Gln Trp 1595 1600 1605Thr Leu Phe Phe Gln Asn Gly
Lys Val Lys Val Phe Gln Gly Asn 1610 1615 1620Gln Asp Ser Phe Thr
Pro Val Val Asn Ser Leu Asp Pro Pro Leu 1625 1630 1635Leu Thr Arg
Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln 1640 1645 1650Ile
Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu 1655 1660
1665Tyr1241684PRTArtificial SequenceSynthetic Sequence 124Ala Thr
Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1 5 10 15Met
Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25
30Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys
35 40 45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys
Pro 50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala
Glu Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala
Ser His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys
Ala Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser Gln Arg
Glu Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser His Thr
Tyr Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met Ala Ser
Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155 160His Val
Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170
175Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu
180 185 190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys
Ser Trp 195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg
Asp Ala Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His Thr Val
Asn Gly Tyr Val Asn Arg225 230 235 240Ser Leu Pro Gly Leu Ile Gly
Cys His Arg Lys Ser Val Tyr Trp His 245 250 255Val Ile Gly Met Gly
Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270Gly His Thr
Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285Ser
Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295
300Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly
Met305 310 315 320Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu
Pro Gln Leu Arg 325 330 335Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr
Asp Asp Asp Leu Thr Asp 340 345 350Ser Glu Met Asp Val Val Arg Phe
Asp Asp Asp Asn Ser Pro Ser Phe 355 360 365Ile Gln Ile Arg Ser Val
Ala Lys Lys His Pro Lys Thr Trp Val His 370 375 380Tyr Ile Ala Ala
Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu385 390 395 400Ala
Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410
415Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr
420 425 430Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser
Gly Ile 435 440 445Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr
Leu Leu Ile Ile 450 455 460Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn
Ile Tyr Pro His Gly Ile465 470 475 480Thr Asp Val Arg Pro Leu Tyr
Ser Arg Arg Leu Pro Lys Gly Val Lys 485 490 495His Leu Lys Asp Phe
Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510Trp Thr Val
Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525Leu
Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535
540Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val
Asp545 550 555 560Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn
Val Ile Leu Phe 565 570 575Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr
Leu Thr Glu Asn Ile Gln 580 585 590Arg Phe Leu Pro Asn Pro Ala Gly
Val Gln Leu Glu Asp Pro Glu Phe 595 600 605Gln Ala Ser Asn Ile Met
His Ser Ile Asn Gly Tyr Val Phe Asp Ser 610 615 620Leu Gln Leu Ser
Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu625 630 635 640Ser
Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 645 650
655Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro
660 665 670Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly
Leu Trp 675 680 685Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg
Gly Met Thr Ala 690 695 700Leu Leu Lys Val Ser Ser Cys Asp Lys Asn
Thr Gly Asp Tyr Tyr Glu705 710 715 720Asp Ser Tyr Glu Asp Ile Ser
Ala Tyr Leu Leu Ser Lys Asn Asn Ala 725 730 735Ile Glu Pro Arg Ser
Phe Ser Gln Asn Gly Gly Gly Gly Ser Thr Gly 740 745 750Gly Thr Gly
Gly Ser Ser Gly Gly Gly Thr Gly Ser Gly Gly Gly Gly 755 760 765Thr
Gly Gly Ser Gly Gly Thr Asp Ile Gln Leu Thr Gln Ser Pro Ser 770 775
780Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg
Ala785 790 795 800Ser Ser Ser Val Arg Tyr Ile Tyr Trp Phe Gln Gln
Lys Pro Gly Lys 805 810 815Ala Pro Lys Leu Leu Ile Tyr Ala Thr Ser
Phe Arg Gln Ser Gly Val 820 825 830Pro Ser Arg Phe Ser Gly Ser Gly
Ser Gly Thr Glu Tyr Thr Leu Thr 835 840 845Ile Ser Ser Leu Gln Pro
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln 850 855 860Arg Asn Ser Phe
Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile865 870 875 880Lys
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 885 890
895Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val
900 905 910Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser
Gly Tyr 915 920 925Thr Phe Thr Thr Tyr Ala Ile His Trp Val Arg Gln
Ala Pro Gly Gln 930 935 940Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro
Ser Ser Gly Tyr Thr Arg945 950 955 960Tyr Asn Pro Lys Phe Lys Gly
Arg Val Thr Met Thr Arg Asp Lys Ser 965 970 975Thr Ser Thr Ala Tyr
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr 980 985 990Ala Val Tyr
Tyr Cys Trp Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly 995 1000
1005Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Asn Pro
1010 1015
1020Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Asp Glu Asn Gln
1025 1030 1035Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe
Ile Ala 1040 1045 1050Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser
Ser Ser Pro His 1055 1060 1065Val Leu Arg Asn Arg Ala Gln Ser Gly
Ser Val Pro Gln Phe Lys 1070 1075 1080Lys Val Val Phe Gln Glu Phe
Thr Asp Gly Ser Phe Thr Gln Pro 1085 1090 1095Leu Tyr Arg Gly Glu
Leu Asn Glu His Leu Gly Leu Leu Gly Pro 1100 1105 1110Tyr Ile Arg
Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg 1115 1120 1125Asn
Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 1130 1135
1140Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe
1145 1150 1155Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val
Gln His 1160 1165 1170His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys
Lys Ala Trp Ala 1175 1180 1185Tyr Phe Ser Asp Val Asp Leu Glu Lys
Asp Val His Ser Gly Leu 1190 1195 1200Ile Gly Pro Leu Leu Val Cys
His Thr Asn Thr Leu Asn Pro Ala 1205 1210 1215His Gly Arg Gln Val
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr 1220 1225 1230Ile Phe Asp
Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu 1235 1240 1245Arg
Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr 1250 1255
1260Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met
1265 1270 1275Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg
Ile Arg 1280 1285 1290Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn
Ile His Ser Ile 1295 1300 1305His Phe Ser Gly His Val Phe Thr Val
Arg Lys Lys Glu Glu Tyr 1310 1315 1320Lys Met Ala Leu Tyr Asn Leu
Tyr Pro Gly Val Phe Glu Thr Val 1325 1330 1335Glu Met Leu Pro Ser
Lys Ala Gly Ile Trp Arg Val Glu Cys Leu 1340 1345 1350Ile Gly Glu
His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val 1355 1360 1365Tyr
Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 1370 1375
1380Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp
1385 1390 1395Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile
Asn Ala 1400 1405 1410Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys
Val Asp Leu Leu 1415 1420 1425Ala Pro Met Ile Ile His Gly Ile Lys
Thr Gln Gly Ala Arg Gln 1430 1435 1440Lys Phe Ser Ser Leu Tyr Ile
Ser Gln Phe Ile Ile Met Tyr Ser 1445 1450 1455Leu Asp Gly Lys Lys
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly 1460 1465 1470Thr Leu Met
Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys 1475 1480 1485His
Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu 1490 1495
1500His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu
1505 1510 1515Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly
Met Glu 1520 1525 1530Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala
Ser Ser Tyr Phe 1535 1540 1545Thr Asn Met Phe Ala Thr Trp Ser Pro
Ser Lys Ala Arg Leu His 1550 1555 1560Leu Gln Gly Arg Ser Asn Ala
Trp Arg Pro Gln Val Asn Asn Pro 1565 1570 1575Lys Glu Trp Leu Gln
Val Asp Phe Gln Lys Thr Met Lys Val Thr 1580 1585 1590Gly Val Thr
Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr 1595 1600 1605Val
Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 1610 1615
1620Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn
1625 1630 1635Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro
Pro Leu 1640 1645 1650Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser
Trp Val His Gln 1655 1660 1665Ile Ala Leu Arg Met Glu Val Leu Gly
Cys Glu Ala Gln Asp Leu 1670 1675 1680Tyr1251661PRTArtificial
SequenceSynthetic Sequence 125Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Ser Ser Val Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ala Thr Ser Phe Arg Gln
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu
Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 100 105
110Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val
115 120 125Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
Ser Val 130 135 140Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
Thr Tyr Ala Ile145 150 155 160His Trp Val Arg Gln Ala Pro Gly Gln
Gly Leu Glu Trp Met Gly Tyr 165 170 175Ile Asn Pro Ser Ser Gly Tyr
Thr Arg Tyr Asn Pro Lys Phe Lys Gly 180 185 190Arg Val Thr Met Thr
Arg Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 195 200 205Leu Arg Ser
Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Trp Thr 210 215 220Gly
Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser225 230
235 240Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Leu Val Pro Arg Gly
Ser 245 250 255Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Thr Arg
Arg Tyr Tyr 260 265 270Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr Met
Gln Ser Asp Leu Gly 275 280 285Glu Leu Pro Val Asp Ala Arg Phe Pro
Pro Arg Val Pro Lys Ser Phe 290 295 300Pro Phe Asn Thr Ser Val Val
Tyr Lys Lys Thr Leu Phe Val Glu Phe305 310 315 320Thr Asp His Leu
Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly 325 330 335Leu Leu
Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile 340 345
350Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala Val Gly
355 360 365Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp
Gln Thr 370 375 380Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro
Gly Gly Ser His385 390 395 400Thr Tyr Val Trp Gln Val Leu Lys Glu
Asn Gly Pro Met Ala Ser Asp 405 410 415Pro Leu Cys Leu Thr Tyr Ser
Tyr Leu Ser His Val Asp Leu Val Lys 420 425 430Asp Leu Asn Ser Gly
Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly 435 440 445Ser Leu Ala
Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu 450 455 460Phe
Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn465 470
475 480Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro
Lys 485 490 495Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro
Gly Leu Ile 500 505 510Gly Cys His Arg Lys Ser Val Tyr Trp His Val
Ile Gly Met Gly Thr 515 520 525Thr Pro Glu Val His Ser Ile Phe Leu
Glu Gly His Thr Phe Leu Val 530 535 540Arg Asn His Arg Gln Ala Ser
Leu Glu Ile Ser Pro Ile Thr Phe Leu545 550 555 560Thr Ala Gln Thr
Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys 565 570 575His Ile
Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val 580 585
590Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu
595 600 605Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp
Val Val 610 615 620Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln
Ile Arg Ser Val625 630 635 640Ala Lys Lys His Pro Lys Thr Trp Val
His Tyr Ile Ala Ala Glu Glu 645 650 655Glu Asp Trp Asp Tyr Ala Pro
Leu Val Leu Ala Pro Asp Asp Arg Ser 660 665 670Tyr Lys Ser Gln Tyr
Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys 675 680 685Tyr Lys Lys
Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr 690 695 700Arg
Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr705 710
715 720Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala
Ser 725 730 735Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val
Arg Pro Leu 740 745 750Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His
Leu Lys Asp Phe Pro 755 760 765Ile Leu Pro Gly Glu Ile Phe Lys Tyr
Lys Trp Thr Val Thr Val Glu 770 775 780Asp Gly Pro Thr Lys Ser Asp
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser785 790 795 800Ser Phe Val Asn
Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro 805 810 815Leu Leu
Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile 820 825
830Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn
835 840 845Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro
Asn Pro 850 855 860Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala
Ser Asn Ile Met865 870 875 880His Ser Ile Asn Gly Tyr Val Phe Asp
Ser Leu Gln Leu Ser Val Cys 885 890 895Leu His Glu Val Ala Tyr Trp
Tyr Ile Leu Ser Ile Gly Ala Gln Thr 900 905 910Asp Phe Leu Ser Val
Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met 915 920 925Val Tyr Glu
Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val 930 935 940Phe
Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn945 950
955 960Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser
Ser 965 970 975Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr
Glu Asp Ile 980 985 990Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile
Glu Pro Arg Ser Phe 995 1000 1005Ser Gln Asn Asp Glu Asn Gln Ser
Pro Arg Ser Phe Gln Lys Lys 1010 1015 1020Thr Arg His Tyr Phe Ile
Ala Ala Val Glu Arg Leu Trp Asp Tyr 1025 1030 1035Gly Met Ser Ser
Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser 1040 1045 1050Gly Ser
Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 1055 1060
1065Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu
1070 1075 1080His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val
Glu Asp 1085 1090 1095Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser
Arg Pro Tyr Ser 1100 1105 1110Phe Tyr Ser Ser Leu Ile Ser Tyr Glu
Glu Asp Gln Arg Gln Gly 1115 1120 1125Ala Glu Pro Arg Lys Asn Phe
Val Lys Pro Asn Glu Thr Lys Thr 1130 1135 1140Tyr Phe Trp Lys Val
Gln His His Met Ala Pro Thr Lys Asp Glu 1145 1150 1155Phe Asp Cys
Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu 1160 1165 1170Lys
Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His 1175 1180
1185Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln
1190 1195 1200Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys
Ser Trp 1205 1210 1215Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg
Ala Pro Cys Asn 1220 1225 1230Ile Gln Met Glu Asp Pro Thr Phe Lys
Glu Asn Tyr Arg Phe His 1235 1240 1245Ala Ile Asn Gly Tyr Ile Met
Asp Thr Leu Pro Gly Leu Val Met 1250 1255 1260Ala Gln Asp Gln Arg
Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser 1265 1270 1275Asn Glu Asn
Ile His Ser Ile His Phe Ser Gly His Val Phe Thr 1280 1285 1290Val
Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr 1295 1300
1305Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly
1310 1315 1320Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His
Ala Gly 1325 1330 1335Met Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys
Cys Gln Thr Pro 1340 1345 1350Leu Gly Met Ala Ser Gly His Ile Arg
Asp Phe Gln Ile Thr Ala 1355 1360 1365Ser Gly Gln Tyr Gly Gln Trp
Ala Pro Lys Leu Ala Arg Leu His 1370 1375 1380Tyr Ser Gly Ser Ile
Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser 1385 1390 1395Trp Ile Lys
Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile 1400 1405 1410Lys
Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser 1415 1420
1425Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr
1430 1435 1440Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe
Gly Asn 1445 1450 1455Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe
Asn Pro Pro Ile 1460 1465 1470Ile Ala Arg Tyr Ile Arg Leu His Pro
Thr His Tyr Ser Ile Arg 1475 1480 1485Ser Thr Leu Arg Met Glu Leu
Met Gly Cys Asp Leu Asn Ser Cys 1490 1495 1500Ser Met Pro Leu Gly
Met Glu Ser Lys Ala Ile Ser Asp Ala Gln 1505 1510 1515Ile Thr Ala
Ser Ser Tyr Lys Thr Asn Met Phe Ala Thr Trp Ser 1520 1525 1530Pro
Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp 1535 1540
1545Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe
1550 1555 1560Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly
Val Lys 1565 1570 1575Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe
Leu Ile Ser Ser 1580 1585 1590Ser Gln Asp Gly His Gln Trp Thr Leu
Phe Phe Gln Asn Gly Lys 1595 1600 1605Val Lys Val Phe Gln Gly Asn
Gln Asp Ser Phe Thr Pro Val Val 1610 1615 1620Asn Ser Leu Asp Pro
Pro Leu Leu Thr Arg Tyr Leu Arg Ile His 1625 1630 1635Pro Gln Ser
Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu 1640 1645 1650Gly
Cys Glu Ala Gln Asp Leu Tyr 1655 16601261661PRTArtificial
SequenceSynthetic Sequence 126Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Ser Ser Val Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ala Thr Ser Phe Arg Gln
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu
Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 100 105
110Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 115 120 125Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 130 135 140Lys Val
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Ala Ile145 150 155
160His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr
165 170 175Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe
Lys Gly 180 185 190Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr
Ala Tyr Met Glu 195 200 205Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala
Val Tyr Tyr Cys Trp Thr 210 215 220Gly Thr Arg Asp Tyr Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser225 230 235 240Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Leu Val Pro Arg Gly Ser 245 250 255Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Ala Thr Arg Arg Tyr Tyr 260 265 270Leu
Gly Ala Val Glu Leu Ser Trp Asp Tyr Met Gln Ser Asp Leu Gly 275 280
285Glu Leu Pro Val Asp Ala Arg Phe Pro Pro Arg Val Pro Lys Ser Phe
290 295 300Pro Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val
Glu Phe305 310 315 320Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg
Pro Pro Trp Met Gly 325 330 335Leu Leu Gly Pro Thr Ile Gln Ala Glu
Val Tyr Asp Thr Val Val Ile 340 345 350Thr Leu Lys Asn Met Ala Ser
His Pro Val Ser Leu His Ala Val Gly 355 360 365Val Ser Tyr Trp Lys
Ala Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr 370 375 380Ser Gln Arg
Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly Ser His385 390 395
400Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp
405 410 415Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu
Val Lys 420 425 430Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val
Cys Arg Glu Gly 435 440 445Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu
His Lys Phe Ile Leu Leu 450 455 460Phe Ala Val Phe Asp Glu Gly Lys
Ser Trp His Ser Glu Thr Lys Asn465 470 475 480Ser Leu Met Gln Asp
Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys 485 490 495Met His Thr
Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile 500 505 510Gly
Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr 515 520
525Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val
530 535 540Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr
Phe Leu545 550 555 560Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln
Phe Leu Leu Phe Cys 565 570 575His Ile Ser Ser His Gln His Asp Gly
Met Glu Ala Tyr Val Lys Val 580 585 590Asp Ser Cys Pro Glu Glu Pro
Gln Leu Arg Met Lys Asn Asn Glu Glu 595 600 605Ala Glu Asp Tyr Asp
Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val 610 615 620Arg Phe Asp
Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val625 630 635
640Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu
645 650 655Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp
Arg Ser 660 665 670Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg
Ile Gly Arg Lys 675 680 685Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr
Asp Glu Thr Phe Lys Thr 690 695 700Arg Glu Ala Ile Gln His Glu Ser
Gly Ile Leu Gly Pro Leu Leu Tyr705 710 715 720Gly Glu Val Gly Asp
Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser 725 730 735Arg Pro Tyr
Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu 740 745 750Tyr
Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro 755 760
765Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu
770 775 780Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr
Tyr Ser785 790 795 800Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser
Gly Leu Ile Gly Pro 805 810 815Leu Leu Ile Cys Tyr Lys Glu Ser Val
Asp Gln Arg Gly Asn Gln Ile 820 825 830Met Ser Asp Lys Arg Asn Val
Ile Leu Phe Ser Val Phe Asp Glu Asn 835 840 845Arg Ser Trp Tyr Leu
Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro 850 855 860Ala Gly Val
Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met865 870 875
880His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys
885 890 895Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala
Gln Thr 900 905 910Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe
Lys His Lys Met 915 920 925Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro
Phe Ser Gly Glu Thr Val 930 935 940Phe Met Ser Met Glu Asn Pro Gly
Leu Trp Ile Leu Gly Cys His Asn945 950 955 960Ser Asp Phe Arg Asn
Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser 965 970 975Cys Asp Lys
Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile 980 985 990Ser
Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe 995
1000 1005Ser Gln Asn Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys
Lys 1010 1015 1020Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu
Trp Asp Tyr 1025 1030 1035Gly Met Ser Ser Ser Pro His Val Leu Arg
Asn Arg Ala Gln Ser 1040 1045 1050Gly Ser Val Pro Gln Phe Lys Lys
Val Val Phe Gln Glu Phe Thr 1055 1060 1065Asp Gly Ser Phe Thr Gln
Pro Leu Tyr Arg Gly Glu Leu Asn Glu 1070 1075 1080His Leu Gly Leu
Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp 1085 1090 1095Asn Ile
Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser 1100 1105
1110Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly
1115 1120 1125Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr
Lys Thr 1130 1135 1140Tyr Phe Trp Lys Val Gln His His Met Ala Pro
Thr Lys Asp Glu 1145 1150 1155Phe Asp Cys Lys Ala Trp Ala Tyr Phe
Ser Asp Val Asp Leu Glu 1160 1165 1170Lys Asp Val His Ser Gly Leu
Ile Gly Pro Leu Leu Val Cys His 1175 1180 1185Thr Asn Thr Leu Asn
Pro Ala His Gly Arg Gln Val Thr Val Gln 1190 1195 1200Glu Phe Ala
Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp 1205 1210 1215Tyr
Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn 1220 1225
1230Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His
1235 1240 1245Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu
Val Met 1250 1255 1260Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu
Ser Met Gly Ser 1265 1270 1275Asn Glu Asn Ile His Ser Ile His Phe
Ser Gly His Val Phe Thr 1280 1285 1290Val Arg Lys Lys Glu Glu Tyr
Lys Met Ala Leu Tyr Asn Leu Tyr 1295 1300 1305Pro Gly Val Phe Glu
Thr Val Glu Met Leu Pro Ser Lys Ala Gly 1310 1315 1320Ile Trp Arg
Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly 1325 1330 1335Met
Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro 1340 1345
1350Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala
1355 1360 1365Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg
Leu His 1370 1375 1380Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys
Glu Pro Phe Ser 1385 1390 1395Trp Ile Lys Val Asp Leu Leu Ala Pro
Met Ile Ile His Gly Ile 1400 1405 1410Lys Thr Gln Gly Ala Arg Gln
Lys Phe Ser Ser Leu Tyr Ile Ser 1415 1420 1425Gln Phe Ile Ile Met
Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr 1430 1435 1440Tyr Arg Gly
Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn 1445 1450 1455Val
Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile 1460 1465
1470Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg
1475 1480 1485Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn
Ser Cys 1490 1495 1500Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile
Ser Asp Ala Gln 1505 1510 1515Ile Thr Ala Ser Ser Tyr Phe Thr Asn
Met Phe Ala Thr Trp Ser 1520 1525 1530Pro Ser Lys Ala Arg Leu His
Leu Gln Gly Arg Ser Asn Ala Trp 1535 1540 1545Arg Pro Gln Val Asn
Asn Pro Lys Glu Trp Leu Gln Val Asp Phe 1550 1555 1560Gln Lys Thr
Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys 1565 1570 1575Ser
Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser 1580 1585
1590Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys
1595 1600 1605Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro
Val Val 1610 1615 1620Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr
Leu Arg Ile His 1625 1630 1635Pro Gln Ser Trp Val His Gln Ile Ala
Leu Arg Met Glu Val Leu 1640 1645 1650Gly Cys Glu Ala Gln Asp Leu
Tyr 1655 16601271927PRTArtificial SequenceSynthetic Sequence 127Asp
Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10
15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile
20 25 30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
Tyr 35 40 45Ala Thr Ser Phe Arg Gln Ser Gly Val Pro Ser Arg Phe Ser
Gly Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu
Gln Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Asn
Ser Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
Gly Gly Gly Gly Ser Gly 100 105 110Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Glu Val 115 120 125Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ala Ser Val 130 135 140Lys Val Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Ala Ile145 150 155 160His
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr 165 170
175Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe Lys Gly
180 185 190Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr
Met Glu 195 200 205Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr
Tyr Cys Trp Thr 210 215 220Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr
Thr Val Thr Val Ser Ser225 230 235 240Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Leu Val Pro Arg Gly Ser 245 250 255Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Ala Thr Arg Arg Tyr Tyr 260 265 270Leu Gly Ala
Val Glu Leu Ser Trp Asp Tyr Met Gln Ser Asp Leu Gly 275 280 285Glu
Leu Pro Val Asp Ala Arg Phe Pro Pro Arg Val Pro Lys Ser Phe 290 295
300Pro Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val Glu
Phe305 310 315 320Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro
Pro Trp Met Gly 325 330 335Leu Leu Gly Pro Thr Ile Gln Ala Glu Val
Tyr Asp Thr Val Val Ile 340 345 350Thr Leu Lys Asn Met Ala Ser His
Pro Val Ser Leu His Ala Val Gly 355 360 365Val Ser Tyr Trp Lys Ala
Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr 370 375 380Ser Gln Arg Glu
Lys Glu Asp Asp Lys Val Phe Pro Gly Gly Ser His385 390 395 400Thr
Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp 405 410
415Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu Val Lys
420 425 430Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg
Glu Gly 435 440 445Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys
Phe Ile Leu Leu 450 455 460Phe Ala Val Phe Asp Glu Gly Lys Ser Trp
His Ser Glu Thr Lys Asn465 470 475 480Ser Leu Met Gln Asp Arg Asp
Ala Ala Ser Ala Arg Ala Trp Pro Lys 485 490 495Met His Thr Val Asn
Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile 500 505 510Gly Cys His
Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr 515 520 525Thr
Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val 530 535
540Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe
Leu545 550 555 560Thr Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe
Leu Leu Phe Cys 565 570 575His Ile Ser Ser His Gln His Asp Gly Met
Glu Ala Tyr Val Lys Val 580 585 590Asp Ser Cys Pro Glu Glu Pro Gln
Leu Arg Met Lys Asn Asn Glu Glu 595 600 605Ala Glu Asp Tyr Asp Asp
Asp Leu Thr Asp Ser Glu Met Asp Val Val 610 615 620Arg Phe Asp Asp
Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val625 630 635 640Ala
Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu 645 650
655Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser
660 665 670Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly
Arg Lys 675 680 685Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu
Thr Phe Lys Thr 690 695 700Arg Glu Ala Ile Gln His Glu Ser Gly Ile
Leu Gly Pro Leu Leu Tyr705 710 715 720Gly Glu Val Gly Asp Thr Leu
Leu Ile Ile Phe Lys Asn Gln Ala Ser 725 730 735Arg Pro Tyr Asn Ile
Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu 740 745 750Tyr Ser Arg
Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro 755 760 765Ile
Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu 770 775
780Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr
Ser785 790 795 800Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly
Leu Ile Gly Pro 805 810 815Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp
Gln Arg Gly Asn Gln Ile 820 825 830Met Ser Asp Lys Arg Asn Val Ile
Leu Phe Ser Val Phe Asp Glu Asn 835 840 845Arg Ser Trp Tyr Leu Thr
Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro 850 855 860Ala Gly Val Gln
Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met865 870 875 880His
Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys 885 890
895Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr
900
905 910Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys
Met 915 920 925Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly
Glu Thr Val 930 935 940Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile
Leu Gly Cys His Asn945 950 955 960Ser Asp Phe Arg Asn Arg Gly Met
Thr Ala Leu Leu Lys Val Ser Ser 965 970 975Cys Asp Lys Asn Thr Gly
Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile 980 985 990Ser Ala Tyr Leu
Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe 995 1000 1005Ser
Gln Asn Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 1010 1015
1020Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr
1025 1030 1035Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala
Gln Ser 1040 1045 1050Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe
Gln Glu Phe Thr 1055 1060 1065Asp Gly Ser Phe Thr Gln Pro Leu Tyr
Arg Gly Glu Leu Asn Glu 1070 1075 1080His Leu Gly Leu Leu Gly Pro
Tyr Ile Arg Ala Glu Val Glu Asp 1085 1090 1095Asn Ile Met Val Thr
Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser 1100 1105 1110Phe Tyr Ser
Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly 1115 1120 1125Ala
Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr 1130 1135
1140Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu
1145 1150 1155Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp
Leu Glu 1160 1165 1170Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu
Leu Val Cys His 1175 1180 1185Thr Asn Thr Leu Asn Pro Ala His Gly
Arg Gln Val Thr Val Gln 1190 1195 1200Glu Phe Ala Leu Phe Phe Thr
Ile Phe Asp Glu Thr Lys Ser Trp 1205 1210 1215Tyr Phe Thr Glu Asn
Met Glu Arg Asn Cys Arg Ala Pro Cys Asn 1220 1225 1230Ile Gln Met
Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 1235 1240 1245Ala
Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met 1250 1255
1260Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser
1265 1270 1275Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val
Phe Thr 1280 1285 1290Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu
Tyr Asn Leu Tyr 1295 1300 1305Pro Gly Val Phe Glu Thr Val Glu Met
Leu Pro Ser Lys Ala Gly 1310 1315 1320Ile Trp Arg Val Glu Cys Leu
Ile Gly Glu His Leu His Ala Gly 1325 1330 1335Met Ser Thr Leu Phe
Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro 1340 1345 1350Leu Gly Met
Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala 1355 1360 1365Ser
Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His 1370 1375
1380Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser
1385 1390 1395Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His
Gly Ile 1400 1405 1410Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser
Leu Tyr Ile Ser 1415 1420 1425Gln Phe Ile Ile Met Tyr Ser Leu Asp
Gly Lys Lys Trp Gln Thr 1430 1435 1440Tyr Arg Gly Asn Ser Thr Gly
Thr Leu Met Val Phe Phe Gly Asn 1445 1450 1455Val Asp Ser Ser Gly
Ile Lys His Asn Ile Phe Asn Pro Pro Ile 1460 1465 1470Ile Ala Arg
Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 1475 1480 1485Ser
Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys 1490 1495
1500Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln
1505 1510 1515Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr
Trp Ser 1520 1525 1530Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg
Ser Asn Ala Trp 1535 1540 1545Arg Pro Gln Val Asn Asn Pro Lys Glu
Trp Leu Gln Val Asp Phe 1550 1555 1560Gln Lys Thr Met Lys Val Thr
Gly Val Thr Thr Gln Gly Val Lys 1565 1570 1575Ser Leu Leu Thr Ser
Met Tyr Val Lys Glu Phe Leu Ile Ser Ser 1580 1585 1590Ser Gln Asp
Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys 1595 1600 1605Val
Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val 1610 1615
1620Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His
1625 1630 1635Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu
Val Leu 1640 1645 1650Gly Cys Glu Ala Gln Asp Leu Tyr Gly Gly Gly
Ser Gly Gly Gly 1655 1660 1665Gly Ser Gly Leu Val Pro Arg Gly Ser
Gly Gly Gly Ser Gly Gly 1670 1675 1680Gly Gly Ser Gly Asp Ile Gln
Leu Thr Gln Ser Pro Ser Phe Leu 1685 1690 1695Ser Ala Ser Val Gly
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 1700 1705 1710Ser Ser Val
Arg Tyr Ile Tyr Trp Phe Gln Gln Lys Pro Gly Lys 1715 1720 1725Ala
Pro Lys Leu Leu Ile Tyr Ala Thr Ser Phe Arg Gln Ser Gly 1730 1735
1740Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Tyr Thr
1745 1750 1755Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
Tyr Tyr 1760 1765 1770Cys His Gln Arg Asn Ser Phe Pro Tyr Thr Phe
Gly Gln Gly Thr 1775 1780 1785Lys Leu Glu Ile Lys Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser 1790 1795 1800Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Glu Val Gln Leu Val 1805 1810 1815Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala Ser Val Lys Val 1820 1825 1830Ser Cys Lys
Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Ala Ile His 1835 1840 1845Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr 1850 1855
1860Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe Lys
1865 1870 1875Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr
Ala Tyr 1880 1885 1890Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr
Ala Val Tyr Tyr 1895 1900 1905Cys Trp Thr Gly Thr Arg Asp Tyr Trp
Gly Gln Gly Thr Thr Val 1910 1915 1920Thr Val Ser Ser
19251281935PRTArtificial SequenceSynthetic Sequence 128Ala Thr Arg
Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1 5 10 15Met Gln
Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25 30Arg
Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 35 40
45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro
50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu
Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser
His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala
Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu
Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser His Thr Tyr
Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met Ala Ser Asp
Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155 160His Val Asp
Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170 175Leu
Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 180 185
190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp
195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala
Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly
Tyr Val Asn Arg225 230 235 240Ser Leu Pro Gly Leu Ile Gly Cys His
Arg Lys Ser Val Tyr Trp His 245 250 255Val Ile Gly Met Gly Thr Thr
Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270Gly His Thr Phe Leu
Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285Ser Pro Ile
Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295 300Gln
Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met305 310
315 320Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu
Arg 325 330 335Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp
Leu Thr Asp 340 345 350Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp
Asn Ser Pro Ser Phe 355 360 365Ile Gln Ile Arg Ser Val Ala Lys Lys
His Pro Lys Thr Trp Val His 370 375 380Tyr Ile Ala Ala Glu Glu Glu
Asp Trp Asp Tyr Ala Pro Leu Val Leu385 390 395 400Ala Pro Asp Asp
Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410 415Gln Arg
Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 420 425
430Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile
435 440 445Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu
Ile Ile 450 455 460Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr
Pro His Gly Ile465 470 475 480Thr Asp Val Arg Pro Leu Tyr Ser Arg
Arg Leu Pro Lys Gly Val Lys 485 490 495His Leu Lys Asp Phe Pro Ile
Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510Trp Thr Val Thr Val
Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525Leu Thr Arg
Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535 540Ser
Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp545 550
555 560Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu
Phe 565 570 575Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu
Asn Ile Gln 580 585 590Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu
Glu Asp Pro Glu Phe 595 600 605Gln Ala Ser Asn Ile Met His Ser Ile
Asn Gly Tyr Val Phe Asp Ser 610 615 620Leu Gln Leu Ser Val Cys Leu
His Glu Val Ala Tyr Trp Tyr Ile Leu625 630 635 640Ser Ile Gly Ala
Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 645 650 655Thr Phe
Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 660 665
670Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp
675 680 685Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met
Thr Ala 690 695 700Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly
Asp Tyr Tyr Glu705 710 715 720Asp Ser Tyr Glu Asp Ile Ser Ala Tyr
Leu Leu Ser Lys Asn Asn Ala 725 730 735Ile Glu Pro Arg Ser Phe Ser
Gln Asn Gly Gly Gly Gly Ser Thr Gly 740 745 750Gly Thr Gly Gly Ser
Ser Gly Gly Gly Thr Gly Ser Gly Gly Gly Gly 755 760 765Thr Gly Gly
Ser Gly Gly Thr Asp Ile Gln Leu Thr Gln Ser Pro Ser 770 775 780Phe
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala785 790
795 800Ser Ser Ser Val Arg Tyr Ile Tyr Trp Phe Gln Gln Lys Pro Gly
Lys 805 810 815Ala Pro Lys Leu Leu Ile Tyr Ala Thr Ser Phe Arg Gln
Ser Gly Val 820 825 830Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
Glu Tyr Thr Leu Thr 835 840 845Ile Ser Ser Leu Gln Pro Glu Asp Phe
Ala Thr Tyr Tyr Cys His Gln 850 855 860Arg Asn Ser Phe Pro Tyr Thr
Phe Gly Gln Gly Thr Lys Leu Glu Ile865 870 875 880Lys Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 885 890 895Gly Gly
Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 900 905
910Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
915 920 925Thr Phe Thr Thr Tyr Ala Ile His Trp Val Arg Gln Ala Pro
Gly Gln 930 935 940Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Ser
Gly Tyr Thr Arg945 950 955 960Tyr Asn Pro Lys Phe Lys Gly Arg Val
Thr Met Thr Arg Asp Lys Ser 965 970 975Thr Ser Thr Ala Tyr Met Glu
Leu Arg Ser Leu Arg Ser Asp Asp Thr 980 985 990Ala Val Tyr Tyr Cys
Trp Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly 995 1000 1005Thr Thr
Val Thr Val Ser Ser Gly Gly Gly Gly Asp Glu Asn Gln 1010 1015
1020Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala
1025 1030 1035Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser
Pro His 1040 1045 1050Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val
Pro Gln Phe Lys 1055 1060 1065Lys Val Val Phe Gln Glu Phe Thr Asp
Gly Ser Phe Thr Gln Pro 1070 1075 1080Leu Tyr Arg Gly Glu Leu Asn
Glu His Leu Gly Leu Leu Gly Pro 1085 1090 1095Tyr Ile Arg Ala Glu
Val Glu Asp Asn Ile Met Val Thr Phe Arg 1100 1105 1110Asn Gln Ala
Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 1115 1120 1125Tyr
Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 1130 1135
1140Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His
1145 1150 1155His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala
Trp Ala 1160 1165 1170Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val
His Ser Gly Leu 1175 1180 1185Ile Gly Pro Leu Leu Val Cys His Thr
Asn Thr Leu Asn Pro Ala 1190 1195 1200His Gly Arg Gln Val Thr Val
Gln Glu Phe Ala Leu Phe Phe Thr 1205 1210 1215Ile Phe Asp Glu Thr
Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu 1220 1225 1230Arg Asn Cys
Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr 1235 1240 1245Phe
Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met 1250 1255
1260Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg
1265 1270 1275Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His
Ser Ile 1280 1285 1290His Phe Ser Gly His Val Phe Thr Val Arg Lys
Lys Glu Glu Tyr 1295 1300 1305Lys Met Ala Leu Tyr Asn Leu Tyr Pro
Gly Val Phe Glu Thr Val 1310 1315 1320Glu Met Leu Pro Ser Lys Ala
Gly Ile Trp Arg Val Glu Cys Leu 1325 1330 1335Ile Gly Glu His Leu
His Ala Gly Met Ser Thr Leu Phe Leu Val 1340 1345 1350Tyr Ser Asn
Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 1355 1360 1365Ile
Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp 1370 1375
1380Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala
1385 1390 1395Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp
Leu Leu 1400 1405 1410Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln
Gly Ala Arg Gln 1415 1420 1425Lys Phe
Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser 1430 1435
1440Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly
1445 1450 1455Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly
Ile Lys 1460 1465 1470His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg
Tyr Ile Arg Leu 1475 1480 1485His Pro Thr His Tyr Ser Ile Arg Ser
Thr Leu Arg Met Glu Leu 1490 1495 1500Met Gly Cys Asp Leu Asn Ser
Cys Ser Met Pro Leu Gly Met Glu 1505 1510 1515Ser Lys Ala Ile Ser
Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe 1520 1525 1530Thr Asn Met
Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His 1535 1540 1545Leu
Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro 1550 1555
1560Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr
1565 1570 1575Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser
Met Tyr 1580 1585 1590Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp
Gly His Gln Trp 1595 1600 1605Thr Leu Phe Phe Gln Asn Gly Lys Val
Lys Val Phe Gln Gly Asn 1610 1615 1620Gln Asp Ser Phe Thr Pro Val
Val Asn Ser Leu Asp Pro Pro Leu 1625 1630 1635Leu Thr Arg Tyr Leu
Arg Ile His Pro Gln Ser Trp Val His Gln 1640 1645 1650Ile Ala Leu
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu 1655 1660 1665Tyr
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Leu Val Pro Arg 1670 1675
1680Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asp Ile Gln
1685 1690 1695Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
Asp Arg 1700 1705 1710Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val
Arg Tyr Ile Tyr 1715 1720 1725Trp Phe Gln Gln Lys Pro Gly Lys Ala
Pro Lys Leu Leu Ile Tyr 1730 1735 1740Ala Thr Ser Phe Arg Gln Ser
Gly Val Pro Ser Arg Phe Ser Gly 1745 1750 1755Ser Gly Ser Gly Thr
Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln 1760 1765 1770Pro Glu Asp
Phe Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe 1775 1780 1785Pro
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly 1790 1795
1800Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
1805 1810 1815Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys 1820 1825 1830Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys
Ala Ser Gly Tyr 1835 1840 1845Thr Phe Thr Thr Tyr Ala Ile His Trp
Val Arg Gln Ala Pro Gly 1850 1855 1860Gln Gly Leu Glu Trp Met Gly
Tyr Ile Asn Pro Ser Ser Gly Tyr 1865 1870 1875Thr Arg Tyr Asn Pro
Lys Phe Lys Gly Arg Val Thr Met Thr Arg 1880 1885 1890Asp Lys Ser
Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg 1895 1900 1905Ser
Asp Asp Thr Ala Val Tyr Tyr Cys Trp Thr Gly Thr Arg Asp 1910 1915
1920Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 1925 1930
19351291913PRTArtificial SequenceSynthetic Sequence 129Ala Thr Arg
Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr1 5 10 15Met Gln
Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25 30Arg
Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 35 40
45Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro
50 55 60Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu
Val65 70 75 80Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser
His Pro Val 85 90 95Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala
Ser Glu Gly Ala 100 105 110Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu
Lys Glu Asp Asp Lys Val 115 120 125Phe Pro Gly Gly Ser His Thr Tyr
Val Trp Gln Val Leu Lys Glu Asn 130 135 140Gly Pro Met Ala Ser Asp
Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser145 150 155 160His Val Asp
Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170 175Leu
Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 180 185
190His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp
195 200 205His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala
Ala Ser 210 215 220Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly
Tyr Val Asn Arg225 230 235 240Ser Leu Pro Gly Leu Ile Gly Cys His
Arg Lys Ser Val Tyr Trp His 245 250 255Val Ile Gly Met Gly Thr Thr
Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270Gly His Thr Phe Leu
Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285Ser Pro Ile
Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295 300Gln
Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met305 310
315 320Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu
Arg 325 330 335Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp
Leu Thr Asp 340 345 350Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp
Asn Ser Pro Ser Phe 355 360 365Ile Gln Ile Arg Ser Val Ala Lys Lys
His Pro Lys Thr Trp Val His 370 375 380Tyr Ile Ala Ala Glu Glu Glu
Asp Trp Asp Tyr Ala Pro Leu Val Leu385 390 395 400Ala Pro Asp Asp
Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410 415Gln Arg
Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 420 425
430Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile
435 440 445Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu
Ile Ile 450 455 460Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr
Pro His Gly Ile465 470 475 480Thr Asp Val Arg Pro Leu Tyr Ser Arg
Arg Leu Pro Lys Gly Val Lys 485 490 495His Leu Lys Asp Phe Pro Ile
Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510Trp Thr Val Thr Val
Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525Leu Thr Arg
Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535 540Ser
Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp545 550
555 560Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu
Phe 565 570 575Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu
Asn Ile Gln 580 585 590Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu
Glu Asp Pro Glu Phe 595 600 605Gln Ala Ser Asn Ile Met His Ser Ile
Asn Gly Tyr Val Phe Asp Ser 610 615 620Leu Gln Leu Ser Val Cys Leu
His Glu Val Ala Tyr Trp Tyr Ile Leu625 630 635 640Ser Ile Gly Ala
Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 645 650 655Thr Phe
Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 660 665
670Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp
675 680 685Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met
Thr Ala 690 695 700Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly
Asp Tyr Tyr Glu705 710 715 720Asp Ser Tyr Glu Asp Ile Ser Ala Tyr
Leu Leu Ser Lys Asn Asn Ala 725 730 735Ile Glu Pro Arg Ser Phe Ser
Gln Asn Gly Gly Gly Gly Ser Thr Gly 740 745 750Gly Thr Gly Gly Ser
Ser Gly Gly Gly Thr Gly Ser Gly Gly Gly Gly 755 760 765Thr Gly Gly
Ser Gly Gly Thr Asp Ile Gln Leu Thr Gln Ser Pro Ser 770 775 780Phe
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala785 790
795 800Ser Ser Ser Val Arg Tyr Ile Tyr Trp Phe Gln Gln Lys Pro Gly
Lys 805 810 815Ala Pro Lys Leu Leu Ile Tyr Ala Thr Ser Phe Arg Gln
Ser Gly Val 820 825 830Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
Glu Tyr Thr Leu Thr 835 840 845Ile Ser Ser Leu Gln Pro Glu Asp Phe
Ala Thr Tyr Tyr Cys His Gln 850 855 860Arg Asn Ser Phe Pro Tyr Thr
Phe Gly Gln Gly Thr Lys Leu Glu Ile865 870 875 880Lys Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 885 890 895Gly Gly
Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 900 905
910Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
915 920 925Thr Phe Thr Thr Tyr Ala Ile His Trp Val Arg Gln Ala Pro
Gly Gln 930 935 940Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Ser
Gly Tyr Thr Arg945 950 955 960Tyr Asn Pro Lys Phe Lys Gly Arg Val
Thr Met Thr Arg Asp Lys Ser 965 970 975Thr Ser Thr Ala Tyr Met Glu
Leu Arg Ser Leu Arg Ser Asp Asp Thr 980 985 990Ala Val Tyr Tyr Cys
Trp Thr Gly Thr Arg Asp Tyr Trp Gly Gln Gly 995 1000 1005Thr Thr
Val Thr Val Ser Ser Gly Gly Gly Gly Asp Ile Gln Leu 1010 1015
1020Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val
1025 1030 1035Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile
Tyr Trp 1040 1045 1050Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
Leu Ile Tyr Ala 1055 1060 1065Thr Ser Phe Arg Gln Ser Gly Val Pro
Ser Arg Phe Ser Gly Ser 1070 1075 1080Gly Ser Gly Thr Glu Tyr Thr
Leu Thr Ile Ser Ser Leu Gln Pro 1085 1090 1095Glu Asp Phe Ala Thr
Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro 1100 1105 1110Tyr Thr Phe
Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly 1115 1120 1125Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 1130 1135
1140Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
1145 1150 1155Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly
Tyr Thr 1160 1165 1170Phe Thr Thr Tyr Ala Ile His Trp Val Arg Gln
Ala Pro Gly Gln 1175 1180 1185Gly Leu Glu Trp Met Gly Tyr Ile Asn
Pro Ser Ser Gly Tyr Thr 1190 1195 1200Arg Tyr Asn Pro Lys Phe Lys
Gly Arg Val Thr Met Thr Arg Asp 1205 1210 1215Lys Ser Thr Ser Thr
Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser 1220 1225 1230Asp Asp Thr
Ala Val Tyr Tyr Cys Trp Thr Gly Thr Arg Asp Tyr 1235 1240 1245Trp
Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 1250 1255
1260Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His
1265 1270 1275Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly
Met Ser 1280 1285 1290Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln
Ser Gly Ser Val 1295 1300 1305Pro Gln Phe Lys Lys Val Val Phe Gln
Glu Phe Thr Asp Gly Ser 1310 1315 1320Phe Thr Gln Pro Leu Tyr Arg
Gly Glu Leu Asn Glu His Leu Gly 1325 1330 1335Leu Leu Gly Pro Tyr
Ile Arg Ala Glu Val Glu Asp Asn Ile Met 1340 1345 1350Val Thr Phe
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 1355 1360 1365Ser
Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro 1370 1375
1380Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp
1385 1390 1395Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe
Asp Cys 1400 1405 1410Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu
Glu Lys Asp Val 1415 1420 1425His Ser Gly Leu Ile Gly Pro Leu Leu
Val Cys His Thr Asn Thr 1430 1435 1440Leu Asn Pro Ala His Gly Arg
Gln Val Thr Val Gln Glu Phe Ala 1445 1450 1455Leu Phe Phe Thr Ile
Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr 1460 1465 1470Glu Asn Met
Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met 1475 1480 1485Glu
Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn 1490 1495
1500Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp
1505 1510 1515Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn
Glu Asn 1520 1525 1530Ile His Ser Ile His Phe Ser Gly His Val Phe
Thr Val Arg Lys 1535 1540 1545Lys Glu Glu Tyr Lys Met Ala Leu Tyr
Asn Leu Tyr Pro Gly Val 1550 1555 1560Phe Glu Thr Val Glu Met Leu
Pro Ser Lys Ala Gly Ile Trp Arg 1565 1570 1575Val Glu Cys Leu Ile
Gly Glu His Leu His Ala Gly Met Ser Thr 1580 1585 1590Leu Phe Leu
Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met 1595 1600 1605Ala
Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln 1610 1615
1620Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly
1625 1630 1635Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp
Ile Lys 1640 1645 1650Val Asp Leu Leu Ala Pro Met Ile Ile His Gly
Ile Lys Thr Gln 1655 1660 1665Gly Ala Arg Gln Lys Phe Ser Ser Leu
Tyr Ile Ser Gln Phe Ile 1670 1675 1680Ile Met Tyr Ser Leu Asp Gly
Lys Lys Trp Gln Thr Tyr Arg Gly 1685 1690 1695Asn Ser Thr Gly Thr
Leu Met Val Phe Phe Gly Asn Val Asp Ser 1700 1705 1710Ser Gly Ile
Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg 1715 1720 1725Tyr
Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu 1730 1735
1740Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro
1745 1750 1755Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile
Thr Ala 1760 1765 1770Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp
Ser Pro Ser Lys 1775 1780 1785Ala Arg Leu His Leu Gln Gly Arg Ser
Asn Ala Trp Arg Pro Gln 1790 1795 1800Val Asn Asn Pro Lys Glu Trp
Leu Gln Val Asp Phe Gln Lys Thr 1805 1810 1815Met Lys Val Thr Gly
Val Thr Thr Gln Gly Val Lys Ser Leu Leu 1820 1825 1830Thr Ser Met
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp 1835 1840 1845Gly
His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val 1850 1855
1860Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu
1865 1870 1875Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro
Gln Ser 1880 1885 1890Trp Val His Gln Ile Ala Leu Arg Met Glu Val
Leu Gly Cys Glu 1895 1900 1905Ala Gln Asp Leu Tyr
19101301935PRTArtificial SequenceSynthetic Sequence 130Asp Ile Gln
Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg
Val Thr Ile Thr
Cys Arg Ala Ser Ser Ser Val Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ala Thr Ser Phe
Arg Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly
Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65 70 75 80Asp
Phe Ala Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr Thr 85 90
95Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly
100 105 110Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Glu Val 115 120 125Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro
Gly Ala Ser Val 130 135 140Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
Phe Thr Thr Tyr Ala Ile145 150 155 160His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met Gly Tyr 165 170 175Ile Asn Pro Ser Ser
Gly Tyr Thr Arg Tyr Asn Pro Lys Phe Lys Gly 180 185 190Arg Val Thr
Met Thr Arg Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 195 200 205Leu
Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Trp Thr 210 215
220Gly Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
Ser225 230 235 240Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Leu Val
Pro Arg Gly Ser 245 250 255Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Ala Thr Arg Arg Tyr Tyr 260 265 270Leu Gly Ala Val Glu Leu Ser Trp
Asp Tyr Met Gln Ser Asp Leu Gly 275 280 285Glu Leu Pro Val Asp Ala
Arg Phe Pro Pro Arg Val Pro Lys Ser Phe 290 295 300Pro Phe Asn Thr
Ser Val Val Tyr Lys Lys Thr Leu Phe Val Glu Phe305 310 315 320Thr
Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly 325 330
335Leu Leu Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile
340 345 350Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala
Val Gly 355 360 365Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr
Asp Asp Gln Thr 370 375 380Ser Gln Arg Glu Lys Glu Asp Asp Lys Val
Phe Pro Gly Gly Ser His385 390 395 400Thr Tyr Val Trp Gln Val Leu
Lys Glu Asn Gly Pro Met Ala Ser Asp 405 410 415Pro Leu Cys Leu Thr
Tyr Ser Tyr Leu Ser His Val Asp Leu Val Lys 420 425 430Asp Leu Asn
Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly 435 440 445Ser
Leu Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu 450 455
460Phe Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys
Asn465 470 475 480Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg
Ala Trp Pro Lys 485 490 495Met His Thr Val Asn Gly Tyr Val Asn Arg
Ser Leu Pro Gly Leu Ile 500 505 510Gly Cys His Arg Lys Ser Val Tyr
Trp His Val Ile Gly Met Gly Thr 515 520 525Thr Pro Glu Val His Ser
Ile Phe Leu Glu Gly His Thr Phe Leu Val 530 535 540Arg Asn His Arg
Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu545 550 555 560Thr
Ala Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys 565 570
575His Ile Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val
580 585 590Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn
Glu Glu 595 600 605Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu
Met Asp Val Val 610 615 620Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe
Ile Gln Ile Arg Ser Val625 630 635 640Ala Lys Lys His Pro Lys Thr
Trp Val His Tyr Ile Ala Ala Glu Glu 645 650 655Glu Asp Trp Asp Tyr
Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser 660 665 670Tyr Lys Ser
Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys 675 680 685Tyr
Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr 690 695
700Arg Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu
Tyr705 710 715 720Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys
Asn Gln Ala Ser 725 730 735Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile
Thr Asp Val Arg Pro Leu 740 745 750Tyr Ser Arg Arg Leu Pro Lys Gly
Val Lys His Leu Lys Asp Phe Pro 755 760 765Ile Leu Pro Gly Glu Ile
Phe Lys Tyr Lys Trp Thr Val Thr Val Glu 770 775 780Asp Gly Pro Thr
Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser785 790 795 800Ser
Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro 805 810
815Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile
820 825 830Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp
Glu Asn 835 840 845Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe
Leu Pro Asn Pro 850 855 860Ala Gly Val Gln Leu Glu Asp Pro Glu Phe
Gln Ala Ser Asn Ile Met865 870 875 880His Ser Ile Asn Gly Tyr Val
Phe Asp Ser Leu Gln Leu Ser Val Cys 885 890 895Leu His Glu Val Ala
Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr 900 905 910Asp Phe Leu
Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met 915 920 925Val
Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val 930 935
940Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His
Asn945 950 955 960Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu
Lys Val Ser Ser 965 970 975Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu
Asp Ser Tyr Glu Asp Ile 980 985 990Ser Ala Tyr Leu Leu Ser Lys Asn
Asn Ala Ile Glu Pro Arg Ser Phe 995 1000 1005Ser Gln Asn Gly Gly
Gly Gly Ser Thr Gly Gly Thr Gly Gly Ser 1010 1015 1020Ser Gly Gly
Gly Thr Gly Ser Gly Gly Gly Gly Thr Gly Gly Ser 1025 1030 1035Gly
Gly Thr Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser 1040 1045
1050Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser
1055 1060 1065Ser Val Arg Tyr Ile Tyr Trp Phe Gln Gln Lys Pro Gly
Lys Ala 1070 1075 1080Pro Lys Leu Leu Ile Tyr Ala Thr Ser Phe Arg
Gln Ser Gly Val 1085 1090 1095Pro Ser Arg Phe Ser Gly Ser Gly Ser
Gly Thr Glu Tyr Thr Leu 1100 1105 1110Thr Ile Ser Ser Leu Gln Pro
Glu Asp Phe Ala Thr Tyr Tyr Cys 1115 1120 1125His Gln Arg Asn Ser
Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys 1130 1135 1140Leu Glu Ile
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1145 1150 1155Gly
Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln 1160 1165
1170Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser
1175 1180 1185Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Ala Ile
His Trp 1190 1195 1200Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met Gly Tyr Ile 1205 1210 1215Asn Pro Ser Ser Gly Tyr Thr Arg Tyr
Asn Pro Lys Phe Lys Gly 1220 1225 1230Arg Val Thr Met Thr Arg Asp
Lys Ser Thr Ser Thr Ala Tyr Met 1235 1240 1245Glu Leu Arg Ser Leu
Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 1250 1255 1260Trp Thr Gly
Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 1265 1270 1275Val
Ser Ser Gly Gly Gly Gly Asp Glu Asn Gln Ser Pro Arg Ser 1280 1285
1290Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg
1295 1300 1305Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu
Arg Asn 1310 1315 1320Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys
Lys Val Val Phe 1325 1330 1335Gln Glu Phe Thr Asp Gly Ser Phe Thr
Gln Pro Leu Tyr Arg Gly 1340 1345 1350Glu Leu Asn Glu His Leu Gly
Leu Leu Gly Pro Tyr Ile Arg Ala 1355 1360 1365Glu Val Glu Asp Asn
Ile Met Val Thr Phe Arg Asn Gln Ala Ser 1370 1375 1380Arg Pro Tyr
Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp 1385 1390 1395Gln
Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn 1400 1405
1410Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro
1415 1420 1425Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe
Ser Asp 1430 1435 1440Val Asp Leu Glu Lys Asp Val His Ser Gly Leu
Ile Gly Pro Leu 1445 1450 1455Leu Val Cys His Thr Asn Thr Leu Asn
Pro Ala His Gly Arg Gln 1460 1465 1470Val Thr Val Gln Glu Phe Ala
Leu Phe Phe Thr Ile Phe Asp Glu 1475 1480 1485Thr Lys Ser Trp Tyr
Phe Thr Glu Asn Met Glu Arg Asn Cys Arg 1490 1495 1500Ala Pro Cys
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn 1505 1510 1515Tyr
Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro 1520 1525
1530Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu
1535 1540 1545Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe
Ser Gly 1550 1555 1560His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr
Lys Met Ala Leu 1565 1570 1575Tyr Asn Leu Tyr Pro Gly Val Phe Glu
Thr Val Glu Met Leu Pro 1580 1585 1590Ser Lys Ala Gly Ile Trp Arg
Val Glu Cys Leu Ile Gly Glu His 1595 1600 1605Leu His Ala Gly Met
Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys 1610 1615 1620Cys Gln Thr
Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe 1625 1630 1635Gln
Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu 1640 1645
1650Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys
1655 1660 1665Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro
Met Ile 1670 1675 1680Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln
Lys Phe Ser Ser 1685 1690 1695Leu Tyr Ile Ser Gln Phe Ile Ile Met
Tyr Ser Leu Asp Gly Lys 1700 1705 1710Lys Trp Gln Thr Tyr Arg Gly
Asn Ser Thr Gly Thr Leu Met Val 1715 1720 1725Phe Phe Gly Asn Val
Asp Ser Ser Gly Ile Lys His Asn Ile Phe 1730 1735 1740Asn Pro Pro
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His 1745 1750 1755Tyr
Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp 1760 1765
1770Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile
1775 1780 1785Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn
Met Phe 1790 1795 1800Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His
Leu Gln Gly Arg 1805 1810 1815Ser Asn Ala Trp Arg Pro Gln Val Asn
Asn Pro Lys Glu Trp Leu 1820 1825 1830Gln Val Asp Phe Gln Lys Thr
Met Lys Val Thr Gly Val Thr Thr 1835 1840 1845Gln Gly Val Lys Ser
Leu Leu Thr Ser Met Tyr Val Lys Glu Phe 1850 1855 1860Leu Ile Ser
Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe 1865 1870 1875Gln
Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe 1880 1885
1890Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr
1895 1900 1905Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala
Leu Arg 1910 1915 1920Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu
Tyr 1925 1930 19351311681PRTArtificial SequenceSynthetic Sequence
131Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly1
5 10 15Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Arg Tyr
Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
Ile Tyr 35 40 45Ala Thr Ser Phe Arg Gln Ser Gly Val Pro Ser Arg Phe
Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser
Leu Gln Pro Glu65 70 75 80Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg
Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly Gln Gly Thr Lys Leu Glu Ile
Lys Gly Gly Gly Gly Ser Gly 100 105 110Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Glu Val 115 120 125Gln Leu Val Gln Ser
Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 130 135 140Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Ala Ile145 150 155
160His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr
165 170 175Ile Asn Pro Ser Ser Gly Tyr Thr Arg Tyr Asn Pro Lys Phe
Lys Gly 180 185 190Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr
Ala Tyr Met Glu 195 200 205Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala
Val Tyr Tyr Cys Trp Thr 210 215 220Gly Thr Arg Asp Tyr Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser225 230 235 240Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Leu Val Pro Arg Gly Ser 245 250 255Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Ala Thr Arg Arg Tyr Tyr 260 265 270Leu
Gly Ala Val Glu Leu Ser Trp Asp Tyr Met Gln Ser Asp Leu Gly 275 280
285Glu Leu Pro Val Asp Ala Arg Phe Pro Pro Arg Val Pro Lys Ser Phe
290 295 300Pro Phe Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val
Glu Phe305 310 315 320Thr Asp His Leu Phe Asn Ile Ala Lys Pro Arg
Pro Pro Trp Met Gly 325 330 335Leu Leu Gly Pro Thr Ile Gln Ala Glu
Val Tyr Asp Thr Val Val Ile 340 345 350Thr Leu Lys Asn Met Ala Ser
His Pro Val Ser Leu His Ala Val Gly 355 360 365Val Ser Tyr Trp Lys
Ala Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr 370 375 380Ser Gln Arg
Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly Ser His385 390 395
400Thr Tyr Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp
405 410 415Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu
Val Lys 420 425 430Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu Leu Val
Cys Arg Glu Gly 435 440 445Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu
His Lys Phe Ile Leu Leu 450 455 460Phe Ala Val Phe Asp Glu Gly Lys
Ser Trp His Ser Glu Thr Lys Asn465 470 475 480Ser Leu Met Gln Asp
Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys 485 490 495Met His Thr
Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile 500 505 510Gly
Cys His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr 515 520
525Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe
Leu Val 530 535 540Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser Pro
Ile Thr Phe Leu545 550 555 560Thr Ala Gln Thr Leu Leu Met Asp Leu
Gly Gln Phe Leu Leu Phe Cys 565 570 575His Ile Ser Ser His Gln His
Asp Gly Met Glu Ala Tyr Val Lys Val 580 585 590Asp Ser Cys Pro Glu
Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu 595 600 605Ala Glu Asp
Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val 610 615 620Arg
Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val625 630
635 640Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu
Glu 645 650 655Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp
Asp Arg Ser 660 665 670Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln
Arg Ile Gly Arg Lys 675 680 685Tyr Lys Lys Val Arg Phe Met Ala Tyr
Thr Asp Glu Thr Phe Lys Thr 690 695 700Arg Glu Ala Ile Gln His Glu
Ser Gly Ile Leu Gly Pro Leu Leu Tyr705 710 715 720Gly Glu Val Gly
Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser 725 730 735Arg Pro
Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu 740 745
750Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro
755 760 765Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr
Val Glu 770 775 780Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr
Arg Tyr Tyr Ser785 790 795 800Ser Phe Val Asn Met Glu Arg Asp Leu
Ala Ser Gly Leu Ile Gly Pro 805 810 815Leu Leu Ile Cys Tyr Lys Glu
Ser Val Asp Gln Arg Gly Asn Gln Ile 820 825 830Met Ser Asp Lys Arg
Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn 835 840 845Arg Ser Trp
Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro 850 855 860Ala
Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met865 870
875 880His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val
Cys 885 890 895Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly
Ala Gln Thr 900 905 910Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr
Phe Lys His Lys Met 915 920 925Val Tyr Glu Asp Thr Leu Thr Leu Phe
Pro Phe Ser Gly Glu Thr Val 930 935 940Phe Met Ser Met Glu Asn Pro
Gly Leu Trp Ile Leu Gly Cys His Asn945 950 955 960Ser Asp Phe Arg
Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser 965 970 975Cys Asp
Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile 980 985
990Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe
995 1000 1005Ser Gln Asn Gly Gly Gly Gly Gly Ser Gly Gly Ser Gly
Gly Ser 1010 1015 1020Gly Gly Ser Gly Gly Gly Gly Gly Asp Glu Asn
Gln Ser Pro Arg 1025 1030 1035Ser Phe Gln Lys Lys Thr Arg His Tyr
Phe Ile Ala Ala Val Glu 1040 1045 1050Arg Leu Trp Asp Tyr Gly Met
Ser Ser Ser Pro His Val Leu Arg 1055 1060 1065Asn Arg Ala Gln Ser
Gly Ser Val Pro Gln Phe Lys Lys Val Val 1070 1075 1080Phe Gln Glu
Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg 1085 1090 1095Gly
Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg 1100 1105
1110Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala
1115 1120 1125Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr
Glu Glu 1130 1135 1140Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn
Phe Val Lys Pro 1145 1150 1155Asn Glu Thr Lys Thr Tyr Phe Trp Lys
Val Gln His His Met Ala 1160 1165 1170Pro Thr Lys Asp Glu Phe Asp
Cys Lys Ala Trp Ala Tyr Phe Ser 1175 1180 1185Asp Val Asp Leu Glu
Lys Asp Val His Ser Gly Leu Ile Gly Pro 1190 1195 1200Leu Leu Val
Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg 1205 1210 1215Gln
Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp 1220 1225
1230Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys
1235 1240 1245Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe
Lys Glu 1250 1255 1260Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile
Met Asp Thr Leu 1265 1270 1275Pro Gly Leu Val Met Ala Gln Asp Gln
Arg Ile Arg Trp Tyr Leu 1280 1285 1290Leu Ser Met Gly Ser Asn Glu
Asn Ile His Ser Ile His Phe Ser 1295 1300 1305Gly His Val Phe Thr
Val Arg Lys Lys Glu Glu Tyr Lys Met Ala 1310 1315 1320Leu Tyr Asn
Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu 1325 1330 1335Pro
Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu 1340 1345
1350His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asn
1355 1360 1365Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile
Arg Asp 1370 1375 1380Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln
Trp Ala Pro Lys 1385 1390 1395Leu Ala Arg Leu His Tyr Ser Gly Ser
Ile Asn Ala Trp Ser Thr 1400 1405 1410Lys Glu Pro Phe Ser Trp Ile
Lys Val Asp Leu Leu Ala Pro Met 1415 1420 1425Ile Ile His Gly Ile
Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser 1430 1435 1440Ser Leu Tyr
Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly 1445 1450 1455Lys
Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met 1460 1465
1470Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile
1475 1480 1485Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His
Pro Thr 1490 1495 1500His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu
Leu Met Gly Cys 1505 1510 1515Asp Leu Asn Ser Cys Ser Met Pro Leu
Gly Met Glu Ser Lys Ala 1520 1525 1530Ile Ser Asp Ala Gln Ile Thr
Ala Ser Ser Tyr Phe Thr Asn Met 1535 1540 1545Phe Ala Thr Trp Ser
Pro Ser Lys Ala Arg Leu His Leu Gln Gly 1550 1555 1560Arg Ser Asn
Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp 1565 1570 1575Leu
Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr 1580 1585
1590Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu
1595 1600 1605Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp Thr
Leu Phe 1610 1615 1620Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly
Asn Gln Asp Ser 1625 1630 1635Phe Thr Pro Val Val Asn Ser Leu Asp
Pro Pro Leu Leu Thr Arg 1640 1645 1650Tyr Leu Arg Ile His Pro Gln
Ser Trp Val His Gln Ile Ala Leu 1655 1660 1665Arg Met Glu Val Leu
Gly Cys Glu Ala Gln Asp Leu Tyr 1670 1675 16801321661PRTArtificial
SequenceSynthetic Sequence 132Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Ser Ser Val Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ala Thr Ser Phe Arg Gln
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu
Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 100 105
110Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val
115 120 125Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
Ser Val 130 135 140Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
Thr Tyr Ala Ile145 150 155 160His Trp Val Arg Gln Ala Pro Gly Gln
Gly Leu Glu Trp Met Gly Tyr 165 170 175Ile Asn Pro Ser Ser Gly Tyr
Thr Arg Tyr Asn Pro Lys Phe Lys Gly 180 185 190Arg Val Thr Met Thr
Arg Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 195 200 205Leu Arg Ser
Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Trp Thr 210 215 220Gly
Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser225 230
235 240Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Leu Val Pro Arg Gly
Ser 245 250 255Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Thr Arg
Arg Tyr Tyr 260 265 270Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr Met
Gln Ser Asp Leu Gly 275 280 285Glu Leu Pro Val Asp Ala Arg Phe Pro
Pro Arg Val Pro Lys Ser Phe 290 295 300Pro Phe Asn Thr Ser Val Val
Tyr Lys Lys Thr Leu Phe Val Glu Phe305 310 315 320Thr Asp His Leu
Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly 325 330 335Leu Leu
Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile 340 345
350Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala Val Gly
355 360 365Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp
Gln Thr 370 375 380Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro
Gly Gly Ser His385 390 395 400Thr Tyr Val Trp Gln Val Leu Lys Glu
Asn Gly Pro Met Ala Ser Asp 405 410 415Pro Leu Cys Leu Thr Tyr Ser
Tyr Leu Ser His Val Asp Leu Val Lys 420 425 430Asp Leu Asn Ser Gly
Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly 435 440 445Ser Leu Ala
Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu 450 455 460Phe
Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn465 470
475 480Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro
Lys 485 490 495Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro
Gly Leu Ile 500 505 510Gly Cys His Arg Lys Ser Val Tyr Trp His Val
Ile Gly Met Gly Thr 515 520 525Thr Pro Glu Val His Ser Ile Phe Leu
Glu Gly His Thr Phe Leu Val 530 535 540Arg Asn His Arg Gln Ala Ser
Leu Glu Ile Ser Pro Ile Thr Phe Leu545 550 555 560Thr Ala Gln Thr
Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys 565 570 575His Ile
Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val 580 585
590Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu
595 600 605Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp
Val Val 610 615 620Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln
Ile Arg Ser Val625 630 635 640Ala Lys Lys His Pro Lys Thr Trp Val
His Tyr Ile Ala Ala Glu Glu 645 650 655Glu Asp Trp Asp Tyr Ala Pro
Leu Val Leu Ala Pro Asp Asp Arg Ser 660 665 670Tyr Lys Ser Gln Tyr
Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys 675 680 685Tyr Lys Lys
Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr 690 695 700Arg
Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr705 710
715 720Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala
Ser 725 730 735Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val
Arg Pro Leu 740 745 750Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His
Leu Lys Asp Phe Pro 755 760 765Ile Leu Pro Gly Glu Ile Phe Lys Tyr
Lys Trp Thr Val Thr Val Glu 770 775 780Asp Gly Pro Thr Lys Ser Asp
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser785 790 795 800Ser Phe Val Asn
Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro 805 810 815Leu Leu
Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile 820 825
830Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn
835 840 845Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro
Asn Pro 850 855 860Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala
Ser Asn Ile Met865 870 875 880His Ser Ile Asn Gly Tyr Val Phe Asp
Ser Leu Gln Leu Ser Val Cys 885 890 895Leu His Glu Val Ala Tyr Trp
Tyr Ile Leu Ser Ile Gly Ala Gln Thr 900 905 910Asp Phe Leu Ser Val
Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met 915 920 925Val Tyr Glu
Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val 930 935 940Phe
Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn945 950
955 960Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser
Ser 965 970 975Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr
Glu Asp Ile 980 985 990Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile
Glu Pro Gly Gly Gly 995 1000 1005Gly Gly Gly Asp Glu Asn Gln Ser
Pro Arg Ser Phe Gln Lys Lys 1010 1015 1020Thr Arg His Tyr Phe Ile
Ala Ala Val Glu Arg Leu Trp Asp Tyr 1025 1030 1035Gly Met Ser Ser
Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser 1040 1045 1050Gly Ser
Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 1055 1060
1065Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu
1070 1075 1080His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val
Glu Asp 1085 1090 1095Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser
Arg Pro Tyr Ser 1100 1105 1110Phe Tyr Ser Ser Leu Ile Ser Tyr Glu
Glu Asp Gln Arg Gln Gly 1115 1120 1125Ala Glu Pro Arg Lys Asn Phe
Val Lys Pro Asn Glu Thr Lys Thr 1130 1135 1140Tyr Phe Trp Lys Val
Gln His His Met Ala Pro Thr Lys Asp Glu 1145 1150 1155Phe Asp Cys
Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu 1160 1165 1170Lys
Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His 1175 1180
1185Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln
1190 1195 1200Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys
Ser Trp 1205 1210 1215Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg
Ala Pro Cys Asn 1220 1225 1230Ile Gln Met Glu Asp Pro Thr Phe Lys
Glu Asn Tyr Arg Phe His 1235 1240 1245Ala Ile Asn Gly Tyr Ile Met
Asp Thr Leu Pro Gly Leu Val Met 1250 1255 1260Ala Gln Asp Gln Arg
Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser 1265 1270 1275Asn Glu Asn
Ile His Ser Ile His Phe Ser Gly His Val Phe Thr 1280 1285 1290Val
Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr 1295
1300 1305Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala
Gly 1310 1315 1320Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu
His Ala Gly 1325 1330 1335Met Ser Thr Leu Phe Leu Val Tyr Ser Asn
Lys Cys Gln Thr Pro 1340 1345 1350Leu Gly Met Ala Ser Gly His Ile
Arg Asp Phe Gln Ile Thr Ala 1355 1360 1365Ser Gly Gln Tyr Gly Gln
Trp Ala Pro Lys Leu Ala Arg Leu His 1370 1375 1380Tyr Ser Gly Ser
Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser 1385 1390 1395Trp Ile
Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile 1400 1405
1410Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser
1415 1420 1425Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp
Gln Thr 1430 1435 1440Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val
Phe Phe Gly Asn 1445 1450 1455Val Asp Ser Ser Gly Ile Lys His Asn
Ile Phe Asn Pro Pro Ile 1460 1465 1470Ile Ala Arg Tyr Ile Arg Leu
His Pro Thr His Tyr Ser Ile Arg 1475 1480 1485Ser Thr Leu Arg Met
Glu Leu Met Gly Cys Asp Leu Asn Ser Cys 1490 1495 1500Ser Met Pro
Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln 1505 1510 1515Ile
Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser 1520 1525
1530Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp
1535 1540 1545Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val
Asp Phe 1550 1555 1560Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr
Gln Gly Val Lys 1565 1570 1575Ser Leu Leu Thr Ser Met Tyr Val Lys
Glu Phe Leu Ile Ser Ser 1580 1585 1590Ser Gln Asp Gly His Gln Trp
Thr Leu Phe Phe Gln Asn Gly Lys 1595 1600 1605Val Lys Val Phe Gln
Gly Asn Gln Asp Ser Phe Thr Pro Val Val 1610 1615 1620Asn Ser Leu
Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His 1625 1630 1635Pro
Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu 1640 1645
1650Gly Cys Glu Ala Gln Asp Leu Tyr 1655 16601331673PRTArtificial
SequenceSynthetic Sequence 133Asp Ile Gln Leu Thr Gln Ser Pro Ser
Phe Leu Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Ser Ser Val Arg Tyr Ile 20 25 30Tyr Trp Phe Gln Gln Lys Pro
Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45Ala Thr Ser Phe Arg Gln
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60Gly Ser Gly Thr Glu
Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu65 70 75 80Asp Phe Ala
Thr Tyr Tyr Cys His Gln Arg Asn Ser Phe Pro Tyr Thr 85 90 95Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 100 105
110Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val
115 120 125Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
Ser Val 130 135 140Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
Thr Tyr Ala Ile145 150 155 160His Trp Val Arg Gln Ala Pro Gly Gln
Gly Leu Glu Trp Met Gly Tyr 165 170 175Ile Asn Pro Ser Ser Gly Tyr
Thr Arg Tyr Asn Pro Lys Phe Lys Gly 180 185 190Arg Val Thr Met Thr
Arg Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 195 200 205Leu Arg Ser
Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Trp Thr 210 215 220Gly
Thr Arg Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser225 230
235 240Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Leu Val Pro Arg Gly
Ser 245 250 255Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Thr Arg
Arg Tyr Tyr 260 265 270Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr Met
Gln Ser Asp Leu Gly 275 280 285Glu Leu Pro Val Asp Ala Arg Phe Pro
Pro Arg Val Pro Lys Ser Phe 290 295 300Pro Phe Asn Thr Ser Val Val
Tyr Lys Lys Thr Leu Phe Val Glu Phe305 310 315 320Thr Asp His Leu
Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly 325 330 335Leu Leu
Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile 340 345
350Thr Leu Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala Val Gly
355 360 365Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp
Gln Thr 370 375 380Ser Gln Arg Glu Lys Glu Asp Asp Lys Val Phe Pro
Gly Gly Ser His385 390 395 400Thr Tyr Val Trp Gln Val Leu Lys Glu
Asn Gly Pro Met Ala Ser Asp 405 410 415Pro Leu Cys Leu Thr Tyr Ser
Tyr Leu Ser His Val Asp Leu Val Lys 420 425 430Asp Leu Asn Ser Gly
Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly 435 440 445Ser Leu Ala
Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu 450 455 460Phe
Ala Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn465 470
475 480Ser Leu Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro
Lys 485 490 495Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro
Gly Leu Ile 500 505 510Gly Cys His Arg Lys Ser Val Tyr Trp His Val
Ile Gly Met Gly Thr 515 520 525Thr Pro Glu Val His Ser Ile Phe Leu
Glu Gly His Thr Phe Leu Val 530 535 540Arg Asn His Arg Gln Ala Ser
Leu Glu Ile Ser Pro Ile Thr Phe Leu545 550 555 560Thr Ala Gln Thr
Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys 565 570 575His Ile
Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Val 580 585
590Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu
595 600 605Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp
Val Val 610 615 620Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln
Ile Arg Ser Val625 630 635 640Ala Lys Lys His Pro Lys Thr Trp Val
His Tyr Ile Ala Ala Glu Glu 645 650 655Glu Asp Trp Asp Tyr Ala Pro
Leu Val Leu Ala Pro Asp Asp Arg Ser 660 665 670Tyr Lys Ser Gln Tyr
Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys 675 680 685Tyr Lys Lys
Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr 690 695 700Arg
Glu Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr705 710
715 720Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala
Ser 725 730 735Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val
Arg Pro Leu 740 745 750Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys His
Leu Lys Asp Phe Pro 755 760 765Ile Leu Pro Gly Glu Ile Phe Lys Tyr
Lys Trp Thr Val Thr Val Glu 770 775 780Asp Gly Pro Thr Lys Ser Asp
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser785 790 795 800Ser Phe Val Asn
Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro 805 810 815Leu Leu
Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile 820 825
830Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn
835 840 845Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro
Asn Pro 850 855 860Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala
Ser Asn Ile Met865 870 875 880His Ser Ile Asn Gly Tyr Val Phe Asp
Ser Leu Gln Leu Ser Val Cys 885 890 895Leu His Glu Val Ala Tyr Trp
Tyr Ile Leu Ser Ile Gly Ala Gln Thr 900 905 910Asp Phe Leu Ser Val
Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met 915 920 925Val Tyr Glu
Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val 930 935 940Phe
Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn945 950
955 960Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser
Ser 965 970 975Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr
Glu Asp Ile 980 985 990Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile
Glu Pro Arg Ser Phe 995 1000 1005Ser Gln Asn Pro Pro Val Leu Lys
Arg His Gln Arg Glu Ile Thr 1010 1015 1020Asp Glu Asn Gln Ser Pro
Arg Ser Phe Gln Lys Lys Thr Arg His 1025 1030 1035Tyr Phe Ile Ala
Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser 1040 1045 1050Ser Ser
Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 1055 1060
1065Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser
1070 1075 1080Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His
Leu Gly 1085 1090 1095Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu
Asp Asn Ile Met 1100 1105 1110Val Thr Phe Arg Asn Gln Ala Ser Arg
Pro Tyr Ser Phe Tyr Ser 1115 1120 1125Ser Leu Ile Ser Tyr Glu Glu
Asp Gln Arg Gln Gly Ala Glu Pro 1130 1135 1140Arg Lys Asn Phe Val
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp 1145 1150 1155Lys Val Gln
His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys 1160 1165 1170Lys
Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val 1175 1180
1185His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr
1190 1195 1200Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu
Phe Ala 1205 1210 1215Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser
Trp Tyr Phe Thr 1220 1225 1230Glu Asn Met Glu Arg Asn Cys Arg Ala
Pro Cys Asn Ile Gln Met 1235 1240 1245Glu Asp Pro Thr Phe Lys Glu
Asn Tyr Arg Phe His Ala Ile Asn 1250 1255 1260Gly Tyr Ile Met Asp
Thr Leu Pro Gly Leu Val Met Ala Gln Asp 1265 1270 1275Gln Arg Ile
Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn 1280 1285 1290Ile
His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 1295 1300
1305Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val
1310 1315 1320Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile
Trp Arg 1325 1330 1335Val Glu Cys Leu Ile Gly Glu His Leu His Ala
Gly Met Ser Thr 1340 1345 1350Leu Phe Leu Val Tyr Ser Asn Lys Cys
Gln Thr Pro Leu Gly Met 1355 1360 1365Ala Ser Gly His Ile Arg Asp
Phe Gln Ile Thr Ala Ser Gly Gln 1370 1375 1380Tyr Gly Gln Trp Ala
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly 1385 1390 1395Ser Ile Asn
Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys 1400 1405 1410Val
Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln 1415 1420
1425Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile
1430 1435 1440Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr
Arg Gly 1445 1450 1455Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly
Asn Val Asp Ser 1460 1465 1470Ser Gly Ile Lys His Asn Ile Phe Asn
Pro Pro Ile Ile Ala Arg 1475 1480 1485Tyr Ile Arg Leu His Pro Thr
His Tyr Ser Ile Arg Ser Thr Leu 1490 1495 1500Arg Met Glu Leu Met
Gly Cys Asp Leu Asn Ser Cys Ser Met Pro 1505 1510 1515Leu Gly Met
Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala 1520 1525 1530Ser
Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 1535 1540
1545Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln
1550 1555 1560Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln
Lys Thr 1565 1570 1575Met Lys Val Thr Gly Val Thr Thr Gln Gly Val
Lys Ser Leu Leu 1580 1585 1590Thr Ser Met Tyr Val Lys Glu Phe Leu
Ile Ser Ser Ser Gln Asp 1595 1600 1605Gly His Gln Trp Thr Leu Phe
Phe Gln Asn Gly Lys Val Lys Val 1610 1615 1620Phe Gln Gly Asn Gln
Asp Ser Phe Thr Pro Val Val Asn Ser Leu 1625 1630 1635Asp Pro Pro
Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser 1640 1645 1650Trp
Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu 1655 1660
1665Ala Gln Asp Leu Tyr 1670
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