U.S. patent application number 17/536974 was filed with the patent office on 2022-03-17 for anti-cd40 binding molecules having engineered fc domains and therapeutic uses thereof. This patent application is currently assigned to LYVGEN BIOPHARMA CO., LTD.. The applicant listed for this patent is LYVGEN BIOPHARMA CO., LTD., LYVGEN BIOPHARMA (SUZHOU) CO., LTD.. Invention is credited to Jieyi WANG, Yi WU.
Application Number | 20220081487 17/536974 |
Document ID | / |
Family ID | |
Filed Date | 2022-03-17 |
United States Patent Application | 20220081487 |
Kind Code | A1 |
WANG; Jieyi ; et al. | March 17, 2022 |
The disclosure provides CD40-binding molecules comprising engineered human IgG domains, for example, human IgG1, IgG2, and IgG4 variants having mutations in the hinge domain, which exhibit altered binding activity to one or more Fc.gamma. receptors. Also described herein are methods for selectively activating or inhibiting immune responses in a subject using the CD40-binding molecules.
Inventors: | WANG; Jieyi; (Belmont, CA) ; WU; Yi; (Shanghai, CN) | ||||||||||
Applicant: |
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Assignee: | ; LYVGEN BIOPHARMA CO.,
LTD. Shanghai CN LYVGEN BIOPHARMA (SUZHOU) CO., LTD. Suzhou CN |
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Appl. No.: | 17/536974 | ||||||||||
Filed: | November 29, 2021 |
Application Number | Filing Date | Patent Number | ||
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17206685 | Mar 19, 2021 | 11186648 | ||
17536974 | ||||
PCT/IB2019/001135 | Sep 27, 2019 | |||
17206685 | ||||
International Class: | C07K 16/28 20060101 C07K016/28; A61P 35/00 20060101 A61P035/00; A61K 39/395 20060101 A61K039/395; A61K 45/06 20060101 A61K045/06 |
Date | Code | Application Number |
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Sep 28, 2018 | CN | PCT/CN2018/108285 |
Sequence CWU 1
1
2151237PRTHomo sapiens 1Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 20 25 30Phe Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu 35 40 45Val Thr Cys Val Val Val Asp Val
Ser His Glu Asp Pro Glu Val Lys 50 55 60Phe Asn Trp Tyr Val Asp Gly
Val Glu Val His Asn Ala Lys Thr Lys65 70 75 80Pro Arg Glu Glu Gln
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 85 90 95Thr Val Leu His
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 100 105 110Val Ser
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 115 120
125Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
130 135 140Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
Val Lys145 150 155 160Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
Glu Ser Asn Gly Gln 165 170 175Pro Glu Asn Asn Tyr Lys Thr Thr Pro
Pro Val Leu Asp Ser Asp Gly 180 185 190Ser Phe Phe Leu Tyr Ser Lys
Leu Thr Val Asp Lys Ser Arg Trp Gln 195 200 205Gln Gly Asn Val Phe
Ser Cys Ser Val Met His Glu Ala Leu His Asn 210 215 220His Tyr Thr
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225 230 2352233PRTHomo
sapiens 2Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro
Pro Cys1 5 10 15Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe
Pro Pro Lys 20 25 30Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val 35 40 45Val Val Asp Val Ser His Glu Asp Pro Glu Val
Gln Phe Asn Trp Tyr 50 55 60Val Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu65 70 75 80Gln Phe Asn Ser Thr Phe Arg Val
Val Ser Val Leu Thr Val Val His 85 90 95Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys 100 105 110Gly Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 115 120 125Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 130 135 140Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro145 150
155 160Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
Asn 165 170 175Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser
Phe Phe Leu 180 185 190Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val 195 200 205Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr Gln 210 215 220Lys Ser Leu Ser Leu Ser Pro
Gly Lys225 2303234PRTHomo sapiens 3Val Asp Lys Arg Val Glu Ser Lys
Tyr Gly Pro Pro Cys Pro Ser Cys1 5 10 15Pro Ala Pro Glu Phe Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40 45Val Val Val Asp Val
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 50 55 60Tyr Val Asp Gly
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu65 70 75 80Glu Gln
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 85 90 95His
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 100 105
110Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
115 120 125Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln
Glu Glu 130 135 140Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr145 150 155 160Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr Ser Arg Leu
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 195 200 205Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 210 215 220Gln
Lys Ser Leu Ser Leu Ser Leu Gly Lys225 2304234PRTArtificial
SequenceSynthetic 4Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val
Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys 35 40 45Val Val Val Asp Val Ser Gln Glu Asp
Pro Glu Val Gln Phe Asn Trp 50 55 60Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg Glu65 70 75 80Glu Gln Phe Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val Leu 85 90 95His Gln Asp Trp Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 100 105 110Lys Gly Leu
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 115 120 125Gln
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 130 135
140Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr145 150 155 160Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr Ser Arg Leu Thr Val Asp
Lys Ser Arg Trp Gln Glu Gly Asn 195 200 205Val Phe Ser Cys Ser Val
Met His Glu Ala Leu His Asn His Tyr Thr 210 215 220Gln Lys Ser Leu
Ser Leu Ser Leu Gly Lys225 2305234PRTArtificial SequenceSynthetic
5Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5
10 15Pro Pro Cys Pro Ala Pro Glu Leu Leu Ser Val Phe Leu Phe Pro
Pro 20 25 30Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys 35 40 45Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
Phe Asn Trp 50 55 60Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg Glu65 70 75 80Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val Leu 85 90 95His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val Ser Asn 100 105 110Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 130 135 140Met Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr145 150 155
160Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
165 170 175Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe 180 185 190Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn 195 200 205Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr 210 215 220Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys225 2306236PRTArtificial SequenceSynthetic 6Val Asp Lys Lys
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys
Pro Ala Pro Glu Leu Leu Gly Pro Ser Val Phe Leu Phe 20 25 30Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 35 40 45Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 50 55
60Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro65
70 75 80Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
Thr 85 90 95Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val 100 105 110Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala 115 120 125Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg 130 135 140Glu Glu Met Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu Val Lys Gly145 150 155 160Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 165 170 175Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 180 185 190Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 195 200
205Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
210 215 220Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225 230
2357231PRTArtificial SequenceSynthetic 7Val Asp Lys Lys Val Glu Pro
Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Leu Leu
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 20 25 30Asp Thr Leu Met Ile
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 35 40 45Asp Val Ser His
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 50 55 60Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr65 70 75 80Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 85 90
95Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
100 105 110Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg 115 120 125Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
Glu Met Thr Lys 130 135 140Asn Gln Val Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp145 150 155 160Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys 165 170 175Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 180 185 190Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 195 200 205Cys
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 210 215
220Leu Ser Leu Ser Pro Gly Lys225 2308233PRTArtificial
SequenceSynthetic 8Val Asp Lys Lys Val Glu Pro Lys Tyr Gly Pro Pro
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Leu Leu Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys 20 25 30Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys Val 35 40 45Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe Asn Trp Tyr 50 55 60Val Asp Gly Val Glu Val His Asn
Ala Lys Thr Lys Pro Arg Glu Glu65 70 75 80Gln Tyr Asn Ser Thr Tyr
Arg Val Val Ser Val Leu Thr Val Leu His 85 90 95Gln Asp Trp Leu Asn
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 100 105 110Ala Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 115 120 125Pro
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 130 135
140Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro145 150 155 160Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn 165 170 175Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu 180 185 190Tyr Ser Lys Leu Thr Val Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val 195 200 205Phe Ser Cys Ser Val Met
His Glu Ala Leu His Asn His Tyr Thr Gln 210 215 220Lys Ser Leu Ser
Leu Ser Pro Gly Lys225 2309237PRTArtificial SequenceSynthetic 9Val
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10
15Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
20 25 30Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu 35 40 45Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
Glu Lys 50 55 60Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
Lys Thr Lys65 70 75 80Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
Val Val Ser Val Leu 85 90 95Thr Val Leu His Gln Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys 100 105 110Val Ser Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys 115 120 125Ala Lys Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 130 135 140Arg Glu Glu Met
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys145 150 155 160Gly
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 165 170
175Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
180 185 190Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln 195 200 205Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn 210 215 220His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys225 230 23510237PRTArtificial SequenceSynthetic 10Val
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10
15Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
20 25 30Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu 35 40 45Val Thr Cys Val Val Val Asp Val Glu His Glu Asp Pro Glu
Val Lys 50 55 60Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
Lys Thr Lys65 70 75 80Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
Val Val Ser Val Leu 85 90 95Thr Val Leu His Gln Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys 100 105 110Val Ser Asn Lys Ala Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys 115 120 125Ala Lys Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 130 135 140Arg Glu Glu Met
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys145 150 155 160Gly
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 165 170
175Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
180 185 190Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln 195 200 205Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn 210 215 220His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys225 230 23511237PRTArtificial SequenceSynthetic 11Val
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10
15Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
20 25 30Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu 35 40 45Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
Val Lys 50 55 60Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
Lys Thr Lys65 70 75 80Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
Val Val Ser Val Leu 85 90 95Thr Val Leu His Gln Asp Trp Leu Asn Gly
Lys Glu Tyr
Lys Cys Lys 100 105 110Val Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu
Lys Thr Ile Ser Lys 115 120 125Ala Lys Gly Gln Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser 130 135 140Arg Glu Glu Met Thr Lys Asn
Gln Val Ser Leu Thr Cys Leu Val Lys145 150 155 160Gly Phe Tyr Pro
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 165 170 175Pro Glu
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 180 185
190Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
195 200 205Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn 210 215 220His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
Lys225 230 23512237PRTArtificial SequenceSynthetic 12Val Asp Lys
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 20 25 30Phe
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 35 40
45Val Thr Cys Val Val Val Asp Val Glu His Glu Asp Pro Glu Val Lys
50 55 60Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys65 70 75 80Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu 85 90 95Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys 100 105 110Val Ser Asn Lys Ala Phe Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys 115 120 125Ala Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser 130 135 140Arg Glu Glu Met Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys145 150 155 160Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 165 170 175Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 180 185
190Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
195 200 205Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn 210 215 220His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
Lys225 230 23513234PRTArtificial SequenceSynthetic 13Val Asp Lys
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro
Cys Pro Ala Pro Glu Leu Leu Ser Val Phe Leu Phe Pro Pro 20 25 30Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40
45Val Val Val Asp Val Ser His Glu Asp Pro Glu Glu Lys Phe Asn Trp
50 55 60Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
Glu65 70 75 80Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
Thr Val Leu 85 90 95His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val Ser Asn 100 105 110Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg Glu Glu 130 135 140Met Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr145 150 155 160Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185
190Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
195 200 205Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
Tyr Thr 210 215 220Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225
23014234PRTArtificial SequenceSynthetic 14Val Asp Lys Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala
Pro Glu Leu Leu Ser Val Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40 45Val Val Val
Asp Val Glu His Glu Asp Pro Glu Val Lys Phe Asn Trp 50 55 60Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu65 70 75
80Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
85 90 95His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn 100 105 110Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Glu Glu 130 135 140Met Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr145 150 155 160Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 195 200
205Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
210 215 220Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225
23015234PRTArtificial SequenceSynthetic 15Val Asp Lys Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala
Pro Glu Leu Leu Ser Val Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40 45Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 50 55 60Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu65 70 75
80Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
85 90 95His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn 100 105 110Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Glu Glu 130 135 140Met Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr145 150 155 160Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 195 200
205Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
210 215 220Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225
23016234PRTArtificial SequenceSynthetic 16Val Asp Lys Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala
Pro Glu Leu Leu Ser Val Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40 45Val Val Val
Asp Val Glu His Glu Asp Pro Glu Val Lys Phe Asn Trp 50 55 60Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu65 70 75
80Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
85 90 95His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn 100 105 110Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Glu Glu 130 135 140Met Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr145 150 155 160Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 195 200
205Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
210 215 220Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225
23017236PRTArtificial SequenceSynthetic 17Val Asp Lys Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly Pro Ser Val Phe Leu Phe 20 25 30Pro Pro Lys Pro
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 35 40 45Thr Cys Val
Val Val Asp Val Ser His Glu Asp Pro Glu Glu Lys Phe 50 55 60Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro65 70 75
80Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
85 90 95Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val 100 105 110Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala 115 120 125Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg 130 135 140Glu Glu Met Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys Gly145 150 155 160Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 165 170 175Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 180 185 190Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 195 200
205Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
210 215 220Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225 230
23518236PRTArtificial SequenceSynthetic 18Val Asp Lys Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly Pro Ser Val Phe Leu Phe 20 25 30Pro Pro Lys Pro
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 35 40 45Thr Cys Val
Val Val Asp Val Glu His Glu Asp Pro Glu Val Lys Phe 50 55 60Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro65 70 75
80Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
85 90 95Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val 100 105 110Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala 115 120 125Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg 130 135 140Glu Glu Met Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys Gly145 150 155 160Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 165 170 175Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 180 185 190Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 195 200
205Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
210 215 220Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225 230
23519236PRTArtificial SequenceSynthetic 19Val Asp Lys Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly Pro Ser Val Phe Leu Phe 20 25 30Pro Pro Lys Pro
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 35 40 45Thr Cys Val
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 50 55 60Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro65 70 75
80Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
85 90 95Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val 100 105 110Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala 115 120 125Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg 130 135 140Glu Glu Met Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys Gly145 150 155 160Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 165 170 175Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 180 185 190Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 195 200
205Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
210 215 220Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225 230
23520236PRTArtificial SequenceSynthetic 20Val Asp Lys Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly Pro Ser Val Phe Leu Phe 20 25 30Pro Pro Lys Pro
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 35 40 45Thr Cys Val
Val Val Asp Val Glu His Glu Asp Pro Glu Val Lys Phe 50 55 60Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro65 70 75
80Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
85 90 95Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val 100 105 110Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala 115 120 125Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg 130 135 140Glu Glu Met Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys Gly145 150 155 160Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 165 170 175Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 180 185 190Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 195 200
205Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
210 215 220Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225 230
23521237PRTArtificial SequenceSynthetic 21Val Asp Lys Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala
Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 20 25 30Phe Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 35 40 45Val Thr Cys
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 50 55 60Phe Asn
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys65 70 75
80Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
85 90 95Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys 100 105 110Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys 115 120 125Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser 130 135 140Arg Glu Glu Met Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu Val Lys145 150 155 160Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 165 170 175Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 180 185 190Ser
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 195 200
205Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
210 215 220His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225
230 23522237PRTArtificial SequenceSynthetic 22Val Asp Lys Lys Val
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro
Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 20 25 30Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 35 40 45Val Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 50 55 60Phe
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys65 70 75
80Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
85 90 95Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys 100 105 110Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr
Ile Ser Lys 115 120 125Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser 130 135 140Arg Glu Glu Met Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu Val Lys145 150 155 160Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 165 170 175Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 180 185 190Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 195 200
205Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
210 215 220His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225
230 23523231PRTArtificial SequenceSynthetic 23Val Asp Lys Thr Val
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro
Val Ala Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 20 25 30Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 35 40 45Asp Val
Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 50 55 60Gly
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe65 70 75
80Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp
85 90 95Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
Leu 100 105 110Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly
Gln Pro Arg 115 120 125Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Glu Glu Met Thr Lys 130 135 140Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp145 150 155 160Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 165 170 175Thr Thr Pro Pro
Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 180 185 190Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 195 200
205Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
210 215 220Leu Ser Leu Ser Pro Gly Lys225 23024236PRTArtificial
SequenceSynthetic 24Val Asp Lys Thr Val Glu Arg Lys Ser Cys Asp Lys
Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro
Ser Val Phe Leu Phe 20 25 30Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
Ser Arg Thr Pro Glu Val 35 40 45Thr Cys Val Val Val Asp Val Ser His
Glu Asp Pro Glu Val Gln Phe 50 55 60Asn Trp Tyr Val Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro65 70 75 80Arg Glu Glu Gln Phe Asn
Ser Thr Phe Arg Val Val Ser Val Leu Thr 85 90 95Val Val His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 100 105 110Ser Asn Lys
Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 115 120 125Lys
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 130 135
140Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
Gly145 150 155 160Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro 165 170 175Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met
Leu Asp Ser Asp Gly Ser 180 185 190Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln 195 200 205Gly Asn Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn His 210 215 220Tyr Thr Gln Lys
Ser Leu Ser Leu Ser Pro Gly Lys225 230 23525234PRTArtificial
SequenceSynthetic 25Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Phe Leu Gly Gly Pro Ser Val
Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys 35 40 45Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Gln Phe Asn Trp 50 55 60Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg Glu65 70 75 80Glu Gln Phe Asn Ser Thr
Phe Arg Val Val Ser Val Leu Thr Val Val 85 90 95His Gln Asp Trp Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 100 105 110Lys Gly Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 115 120 125Gln
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 130 135
140Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr145 150 155 160Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp
Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr Ser Lys Leu Thr Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn 195 200 205Val Phe Ser Cys Ser Val
Met His Glu Ala Leu His Asn His Tyr Thr 210 215 220Gln Lys Ser Leu
Ser Leu Ser Pro Gly Lys225 23026233PRTArtificial SequenceSynthetic
26Val Asp Lys Thr Val Glu Arg Lys Tyr Gly Pro Pro Cys Pro Pro Cys1
5 10 15Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys 20 25 30Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val 35 40 45Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe
Asn Trp Tyr 50 55 60Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu Glu65 70 75 80Gln Phe Asn Ser Thr Phe Arg Val Val Ser
Val Leu Thr Val Val His 85 90 95Gln Asp Trp Leu Asn Gly Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys 100 105 110Gly Leu Pro Ala Pro Ile Glu
Lys Thr Ile Ser Lys Thr Lys Gly Gln 115 120 125Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 130 135 140Thr Lys Asn
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro145 150 155
160Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
165 170 175Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe
Phe Leu 180 185 190Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln Gly Asn Val 195 200 205Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr Thr Gln 210 215 220Lys Ser Leu Ser Leu Ser Pro Gly
Lys225 23027233PRTArtificial SequenceSynthetic 27Val Asp Lys Thr
Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 20 25 30Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 35 40 45Val
Val Asp Val Ser His Glu Asp Pro Glu Glu Gln Phe Asn Trp Tyr 50 55
60Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu65
70 75 80Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val
His 85 90 95Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys 100 105 110Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Thr Lys Gly Gln 115 120 125Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Glu Glu Met 130 135 140Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr Pro145 150 155 160Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 165 170 175Tyr Lys Thr
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 180 185 190Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 195 200
205Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
210 215 220Lys Ser Leu Ser Leu Ser Pro Gly Lys225
23028233PRTArtificial SequenceSynthetic 28Val Asp Lys Thr Val Glu
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val
Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 20 25 30Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 35 40 45Val Val Asp
Val Glu His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 50 55 60Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu65 70 75
80Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His
85 90 95Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys 100 105 110Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr
Lys Gly Gln 115 120 125Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
Ser Arg Glu Glu Met 130 135 140Thr Lys Asn Gln Val Ser Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro145 150 155 160Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 165 170 175Tyr Lys Thr Thr
Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 180 185 190Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 195 200
205Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
210 215 220Lys Ser Leu Ser Leu Ser Pro Gly Lys225
23029233PRTArtificial SequenceSynthetic 29Val Asp Lys Thr Val Glu
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val
Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 20 25 30Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 35 40 45Val Val Asp
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 50 55 60Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu65 70 75
80Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His
85 90 95Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys 100 105 110Gly Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr
Lys Gly Gln 115 120 125Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
Ser Arg Glu Glu Met 130 135 140Thr Lys Asn Gln Val Ser Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro145 150 155 160Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 165 170 175Tyr Lys Thr Thr
Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 180 185 190Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 195 200
205Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
210 215 220Lys Ser Leu Ser Leu Ser Pro Gly Lys225
23030233PRTArtificial SequenceSynthetic 30Val Asp Lys Thr Val Glu
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val
Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 20 25 30Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 35 40 45Val Val Asp
Val Glu His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 50 55 60Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu65 70 75
80Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His
85 90 95Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys 100 105 110Gly Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr
Lys Gly Gln 115 120 125Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
Ser Arg Glu Glu Met 130 135 140Thr Lys Asn Gln Val Ser Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro145 150 155 160Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 165 170 175Tyr Lys Thr Thr
Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 180 185 190Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 195 200
205Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
210 215 220Lys Ser Leu Ser Leu Ser Pro Gly Lys225
23031231PRTArtificial SequenceSynthetic 31Val Asp Lys Thr Val Glu
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Val
Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 20 25 30Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 35 40 45Asp Val Ser
His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 50 55 60Gly Val
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe65 70 75
80Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp
85 90 95Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
Phe 100 105 110Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly
Gln Pro Arg 115 120 125Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Glu Glu Met Thr Lys 130 135 140Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp145 150 155 160Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 165 170 175Thr Thr Pro Pro
Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 180 185 190Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 195 200
205Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
210 215 220Leu Ser Leu Ser Pro Gly Lys225 23032231PRTArtificial
SequenceSynthetic 32Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val Ala Ser Val Phe Leu Phe
Pro Pro Lys Pro Lys 20 25 30Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val 35 40 45Asp Val Ser His Glu Asp Pro Glu Glu
Gln Phe Asn Trp Tyr Val Asp 50 55
60Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe65
70 75 80Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln
Asp 85 90 95Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Gly Leu 100 105 110Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys
Gly Gln Pro Arg 115 120 125Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
Arg Glu Glu Met Thr Lys 130 135 140Asn Gln Val Ser Leu Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser Asp145 150 155 160Ile Ala Val Glu Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 165 170 175Thr Thr Pro
Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 180 185 190Lys
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 195 200
205Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
210 215 220Leu Ser Leu Ser Pro Gly Lys225 23033231PRTArtificial
SequenceSynthetic 33Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val Ala Ser Val Phe Leu Phe
Pro Pro Lys Pro Lys 20 25 30Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val 35 40 45Asp Val Glu His Glu Asp Pro Glu Val
Gln Phe Asn Trp Tyr Val Asp 50 55 60Gly Val Glu Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln Phe65 70 75 80Asn Ser Thr Phe Arg Val
Val Ser Val Leu Thr Val Val His Gln Asp 85 90 95Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 100 105 110Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 115 120 125Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 130 135
140Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
Asp145 150 155 160Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
Asn Asn Tyr Lys 165 170 175Thr Thr Pro Pro Met Leu Asp Ser Asp Gly
Ser Phe Phe Leu Tyr Ser 180 185 190Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln Gln Gly Asn Val Phe Ser 195 200 205Cys Ser Val Met His Glu
Ala Leu His Asn His Tyr Thr Gln Lys Ser 210 215 220Leu Ser Leu Ser
Pro Gly Lys225 23034231PRTArtificial SequenceSynthetic 34Val Asp
Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro
Ala Pro Pro Val Ala Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 20 25
30Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
35 40 45Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
Asp 50 55 60Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Phe65 70 75 80Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val
Val His Gln Asp 85 90 95Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
Ser Asn Lys Gly Phe 100 105 110Pro Ala Pro Ile Glu Lys Thr Ile Ser
Lys Thr Lys Gly Gln Pro Arg 115 120 125Glu Pro Gln Val Tyr Thr Leu
Pro Pro Ser Arg Glu Glu Met Thr Lys 130 135 140Asn Gln Val Ser Leu
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp145 150 155 160Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 165 170
175Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
180 185 190Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser 195 200 205Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr Gln Lys Ser 210 215 220Leu Ser Leu Ser Pro Gly Lys225
23035231PRTArtificial SequenceSynthetic 35Val Asp Lys Thr Val Glu
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val
Ala Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 20 25 30Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 35 40 45Asp Val Glu
His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 50 55 60Gly Val
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe65 70 75
80Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp
85 90 95Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
Phe 100 105 110Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly
Gln Pro Arg 115 120 125Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Glu Glu Met Thr Lys 130 135 140Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp145 150 155 160Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 165 170 175Thr Thr Pro Pro
Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 180 185 190Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 195 200
205Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
210 215 220Leu Ser Leu Ser Pro Gly Lys225 23036232PRTArtificial
SequenceSynthetic 36Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val Ala Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro 20 25 30Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val 35 40 45Val Asp Val Ser His Glu Asp Pro Glu
Val Gln Phe Asn Trp Tyr Val 50 55 60Asp Gly Val Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln65 70 75 80Phe Asn Ser Thr Phe Arg
Val Val Ser Val Leu Thr Val Val His Gln 85 90 95Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 100 105 110Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 115 120 125Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 130 135
140Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
Ser145 150 155 160Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr 165 170 175Lys Thr Thr Pro Pro Met Leu Asp Ser Asp
Gly Ser Phe Phe Leu Tyr 180 185 190Ser Lys Leu Thr Val Asp Lys Ser
Arg Trp Gln Gln Gly Asn Val Phe 195 200 205Ser Cys Ser Val Met His
Glu Ala Leu His Asn His Tyr Thr Gln Lys 210 215 220Ser Leu Ser Leu
Ser Pro Gly Lys225 23037232PRTArtificial SequenceSynthetic 37Val
Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10
15Pro Ala Pro Pro Val Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
20 25 30Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
Val 35 40 45Val Asp Val Glu His Glu Asp Pro Glu Val Gln Phe Asn Trp
Tyr Val 50 55 60Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
Glu Glu Gln65 70 75 80Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu
Thr Val Val His Gln 85 90 95Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val Ser Asn Lys Gly 100 105 110Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys Thr Lys Gly Gln Pro 115 120 125Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 130 135 140Lys Asn Gln Val
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser145 150 155 160Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170
175Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
180 185 190Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
Val Phe 195 200 205Ser Cys Ser Val Met His Glu Ala Leu His Asn His
Tyr Thr Gln Lys 210 215 220Ser Leu Ser Leu Ser Pro Gly Lys225
23038232PRTArtificial SequenceSynthetic 38Val Asp Lys Thr Val Glu
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val
Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45Val Asp Val
Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 50 55 60Asp Gly
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln65 70 75
80Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln
85 90 95Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Gly 100 105 110Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys
Gly Gln Pro 115 120 125Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
Arg Glu Glu Met Thr 130 135 140Lys Asn Gln Val Ser Leu Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser145 150 155 160Asp Ile Ala Val Glu Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175Lys Thr Thr Pro
Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190Ser Lys
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200
205Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220Ser Leu Ser Leu Ser Pro Gly Lys225 23039231PRTArtificial
SequenceSynthetic 39Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe Leu Ser Val Phe Leu Phe
Pro Pro Lys Pro Lys 20 25 30Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val 35 40 45Asp Val Ser Gln Glu Asp Pro Glu Val
Gln Phe Asn Trp Tyr Val Asp 50 55 60Gly Val Glu Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln Phe65 70 75 80Asn Ser Thr Tyr Arg Val
Val Ser Val Leu Thr Val Leu His Gln Asp 85 90 95Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 100 105 110Pro Ser Ser
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 115 120 125Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 130 135
140Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
Asp145 150 155 160Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
Asn Asn Tyr Lys 165 170 175Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
Ser Phe Phe Leu Tyr Ser 180 185 190Arg Leu Thr Val Asp Lys Ser Arg
Trp Gln Glu Gly Asn Val Phe Ser 195 200 205Cys Ser Val Met His Glu
Ala Leu His Asn His Tyr Thr Gln Lys Ser 210 215 220Leu Ser Leu Ser
Leu Gly Lys225 23040239PRTArtificial SequenceSynthetic 40Val Asp
Lys Arg Val Glu Ser Lys Ser Cys Asp Lys Thr His Thr Pro1 5 10 15Pro
Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 20 25
30Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
35 40 45Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro
Glu 50 55 60Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
Ala Lys65 70 75 80Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr
Arg Val Val Ser 85 90 95Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
Gly Lys Glu Tyr Lys 100 105 110Cys Lys Val Ser Asn Lys Gly Leu Pro
Ser Ser Ile Glu Lys Thr Ile 115 120 125Ser Lys Ala Lys Gly Gln Pro
Arg Glu Pro Gln Val Tyr Thr Leu Pro 130 135 140Pro Ser Gln Glu Glu
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu145 150 155 160Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 165 170
175Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
180 185 190Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys
Ser Arg 195 200 205Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met
His Glu Ala Leu 210 215 220His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser Leu Gly Lys225 230 23541233PRTArtificial SequenceSynthetic
41Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1
5 10 15Pro Ala Pro Glu Phe Leu Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys 20 25 30Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val 35 40 45Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe
Asn Trp Tyr 50 55 60Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu Glu65 70 75 80Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu His 85 90 95Gln Asp Trp Leu Asn Gly Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys 100 105 110Gly Leu Pro Ser Ser Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln 115 120 125Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 130 135 140Thr Lys Asn
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro145 150 155
160Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
165 170 175Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
Phe Leu 180 185 190Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln
Glu Gly Asn Val 195 200 205Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr Thr Gln 210 215 220Lys Ser Leu Ser Leu Ser Leu Gly
Lys225 23042236PRTArtificial SequenceSynthetic 42Val Asp Lys Arg
Val Glu Ser Lys Cys Cys Val Glu Pro Pro Cys Pro1 5 10 15Pro Cys Pro
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 20 25 30Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 35 40 45Thr
Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 50 55
60Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro65
70 75 80Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu
Thr 85 90 95Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val 100 105 110Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr
Ile Ser Lys Ala 115 120 125Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Gln 130 135 140Glu Glu Met Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu Val Lys Gly145 150 155 160Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 165 170 175Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser 180 185 190Phe Phe Leu Tyr Ser Arg Leu Thr
Val Asp Lys Ser Arg Trp Gln Glu 195 200 205Gly Asn Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn His 210 215 220Tyr Thr Gln Lys
Ser Leu Ser Leu Ser Leu Gly Lys225 230 23543234PRTArtificial
SequenceSynthetic 43Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val
Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys 35 40 45Val Val Val Asp Val Ser Gln Glu Asp
Pro Glu Glu Gln Phe Asn Trp 50 55 60Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg Glu65 70 75 80Glu Gln Phe Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val Leu 85 90 95His Gln Asp Trp Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 100 105 110Lys Gly Leu
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 115 120 125Gln
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 130 135
140Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr145 150 155 160Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr Ser Arg Leu Thr Val Asp
Lys Ser Arg Trp Gln Glu Gly Asn 195 200 205Val Phe Ser Cys Ser Val
Met His Glu Ala Leu His Asn His Tyr Thr 210 215 220Gln Lys Ser Leu
Ser Leu Ser Leu Gly Lys225 23044231PRTArtificial SequenceSynthetic
44Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1
5 10 15Pro Ala Pro Glu Phe Leu Ser Val Phe Leu Phe Pro Pro Lys Pro
Lys 20 25 30Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
Val Val 35 40 45Asp Val Ser Gln Glu Asp Pro Glu Glu Gln Phe Asn Trp
Tyr Val Asp 50 55 60Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
Glu Glu Gln Phe65 70 75 80Asn Ser Thr Tyr Arg Val Val Ser Val Leu
Thr Val Leu His Gln Asp 85 90 95Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val Ser Asn Lys Gly Leu 100 105 110Pro Ser Ser Ile Glu Lys Thr
Ile Ser Lys Ala Lys Gly Gln Pro Arg 115 120 125Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 130 135 140Asn Gln Val
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp145 150 155
160Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
165 170 175Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
Tyr Ser 180 185 190Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
Asn Val Phe Ser 195 200 205Cys Ser Val Met His Glu Ala Leu His Asn
His Tyr Thr Gln Lys Ser 210 215 220Leu Ser Leu Ser Leu Gly Lys225
23045234PRTArtificial SequenceSynthetic 45Val Asp Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40 45Val Val Val
Asp Val Ser Gln Glu Asp Pro Glu Glu Gln Phe Asn Trp 50 55 60Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu65 70 75
80Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
85 90 95His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn 100 105 110Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Gln Glu Glu 130 135 140Met Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr145 150 155 160Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 195 200
205Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
210 215 220Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys225
23046234PRTArtificial SequenceSynthetic 46Val Asp Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40 45Val Val Val
Asp Val Glu Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 50 55 60Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu65 70 75
80Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
85 90 95His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn 100 105 110Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Gln Glu Glu 130 135 140Met Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr145 150 155 160Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 195 200
205Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
210 215 220Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys225
23047234PRTArtificial SequenceSynthetic 47Val Asp Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40 45Val Val Val
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 50 55 60Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu65 70 75
80Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
85 90 95His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn 100 105 110Lys Gly Phe Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Gln Glu Glu 130 135 140Met Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr145 150 155 160Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 195 200
205Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
210 215 220Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys225
23048234PRTArtificial SequenceSynthetic 48Val Asp Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40 45Val Val Val
Asp Val Glu Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 50 55 60Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu65 70 75
80Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
85 90 95His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn 100 105 110Lys Gly Phe Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Gln Glu Glu 130 135 140Met Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr145 150 155 160Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 195 200
205Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
210 215 220Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys225
23049231PRTArtificial SequenceSynthetic 49Val Asp Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Val
Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 20 25 30Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 35 40 45Asp Val Ser
Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 50 55 60Gly Val
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe65 70 75
80Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
85 90 95Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
Phe 100 105 110Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro Arg 115 120 125Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln
Glu Glu Met Thr Lys 130 135 140Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp145 150 155 160Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 165 170 175Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 180 185 190Arg Leu
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 195 200
205Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
210 215 220Leu Ser Leu Ser Leu Gly Lys225 23050231PRTArtificial
SequenceSynthetic 50Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe Leu Ser Val Phe Leu Phe
Pro Pro Lys Pro Lys 20 25 30Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val 35 40 45Asp Val Glu Gln Glu Asp Pro Glu Val
Gln Phe Asn Trp Tyr Val Asp 50 55 60Gly Val Glu Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln Phe65 70 75 80Asn Ser Thr Tyr Arg Val
Val Ser Val Leu Thr Val Leu His Gln Asp 85 90 95Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 100 105 110Pro Ser Ser
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 115 120 125Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 130 135
140Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
Asp145 150 155 160Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
Asn Asn Tyr Lys 165 170 175Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
Ser Phe Phe Leu Tyr Ser 180 185 190Arg Leu Thr Val Asp Lys Ser Arg
Trp Gln Glu Gly Asn Val Phe Ser 195 200 205Cys Ser Val Met His Glu
Ala Leu His Asn His Tyr Thr Gln Lys Ser 210 215 220Leu Ser Leu Ser
Leu Gly Lys225 23051231PRTArtificial SequenceSynthetic 51Val Asp
Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro
Ala Pro Glu Phe Leu Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 20 25
30Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
35 40 45Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
Asp 50 55 60Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Phe65 70 75 80Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
Leu His Gln Asp 85 90 95Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
Ser Asn Lys Gly Phe 100 105 110Pro Ser Ser Ile Glu Lys Thr Ile Ser
Lys Ala Lys Gly Gln Pro Arg 115 120 125Glu Pro Gln Val Tyr Thr Leu
Pro Pro Ser Gln Glu Glu Met Thr Lys 130 135 140Asn Gln Val Ser Leu
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp145 150 155 160Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 165 170
175Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
180 185 190Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
Phe Ser 195 200 205Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr Gln Lys Ser 210 215 220Leu Ser Leu Ser Leu Gly Lys225
23052231PRTArtificial SequenceSynthetic 52Val Asp Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe
Leu Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 20 25 30Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 35 40 45Asp Val Glu
Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 50 55 60Gly Val
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe65 70 75
80Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
85 90 95Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
Phe 100 105 110Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro Arg 115 120 125Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln
Glu Glu Met Thr Lys 130 135 140Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp145 150 155 160Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 165 170 175Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 180 185 190Arg Leu
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 195 200
205Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
210 215 220Leu Ser Leu Ser Leu Gly Lys225 23053232PRTArtificial
SequenceSynthetic 53Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe Leu Gly Ser Val Phe Leu
Phe Pro Pro Lys Pro 20 25 30Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val 35 40 45Val Asp Val Ser Gln Glu Asp Pro Glu
Val Gln Phe Asn Trp Tyr Val 50 55 60Asp Gly
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln65 70 75
80Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
85 90 95Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Gly 100 105 110Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro 115 120 125Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
Gln Glu Glu Met Thr 130 135 140Lys Asn Gln Val Ser Leu Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser145 150 155 160Asp Ile Ala Val Glu Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175Lys Thr Thr Pro
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190Ser Arg
Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 195 200
205Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220Ser Leu Ser Leu Ser Leu Gly Lys225 23054233PRTArtificial
SequenceSynthetic 54Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe Leu Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys 20 25 30Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys Val 35 40 45Val Val Asp Val Ser Gln Glu Asp Pro
Glu Glu Gln Phe Asn Trp Tyr 50 55 60Val Asp Gly Val Glu Val His Asn
Ala Lys Thr Lys Pro Arg Glu Glu65 70 75 80Gln Phe Asn Ser Thr Tyr
Arg Val Val Ser Val Leu Thr Val Leu His 85 90 95Gln Asp Trp Leu Asn
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 100 105 110Gly Leu Pro
Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 115 120 125Pro
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 130 135
140Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro145 150 155 160Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn 165 170 175Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu 180 185 190Tyr Ser Arg Leu Thr Val Asp Lys
Ser Arg Trp Gln Glu Gly Asn Val 195 200 205Phe Ser Cys Ser Val Met
His Glu Ala Leu His Asn His Tyr Thr Gln 210 215 220Lys Ser Leu Ser
Leu Ser Leu Gly Lys225 23055233PRTArtificial SequenceSynthetic
55Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1
5 10 15Pro Ala Pro Glu Phe Leu Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys 20 25 30Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val 35 40 45Val Val Asp Val Glu Gln Glu Asp Pro Glu Val Gln Phe
Asn Trp Tyr 50 55 60Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu Glu65 70 75 80Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu His 85 90 95Gln Asp Trp Leu Asn Gly Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys 100 105 110Gly Leu Pro Ser Ser Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln 115 120 125Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 130 135 140Thr Lys Asn
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro145 150 155
160Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
165 170 175Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
Phe Leu 180 185 190Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln
Glu Gly Asn Val 195 200 205Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr Thr Gln 210 215 220Lys Ser Leu Ser Leu Ser Leu Gly
Lys225 23056233PRTArtificial SequenceSynthetic 56Val Asp Lys Arg
Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro
Glu Phe Leu Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 20 25 30Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 35 40 45Val
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 50 55
60Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu65
70 75 80Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
His 85 90 95Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys 100 105 110Gly Phe Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln 115 120 125Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Gln Glu Glu Met 130 135 140Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr Pro145 150 155 160Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 165 170 175Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 180 185 190Tyr
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 195 200
205Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
210 215 220Lys Ser Leu Ser Leu Ser Leu Gly Lys225
23057233PRTArtificial SequenceSynthetic 57Val Asp Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe
Leu Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 20 25 30Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 35 40 45Val Val Asp
Val Glu Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 50 55 60Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu65 70 75
80Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
85 90 95Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys 100 105 110Gly Phe Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala
Lys Gly Gln 115 120 125Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
Ser Gln Glu Glu Met 130 135 140Thr Lys Asn Gln Val Ser Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro145 150 155 160Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 165 170 175Tyr Lys Thr Thr
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 180 185 190Tyr Ser
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 195 200
205Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
210 215 220Lys Ser Leu Ser Leu Ser Leu Gly Lys225
23058232PRTArtificial SequenceSynthetic 58Val Asp Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe
Leu Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45Val Asp Val
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 50 55 60Asp Gly
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln65 70 75
80Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
85 90 95Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Gly 100 105 110Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro 115 120 125Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
Gln Glu Glu Met Thr 130 135 140Lys Asn Gln Val Ser Leu Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser145 150 155 160Asp Ile Ala Val Glu Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175Lys Thr Thr Pro
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190Ser Arg
Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 195 200
205Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220Ser Leu Ser Leu Ser Leu Gly Lys225 23059234PRTArtificial
SequenceSynthetic 59Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val
Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys 35 40 45Val Val Val Asp Val Ser Gln Glu Asp
Pro Glu Val Gln Phe Asn Trp 50 55 60Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg Glu65 70 75 80Glu Gln Phe Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val Leu 85 90 95His Gln Asp Trp Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 100 105 110Lys Gly Leu
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 115 120 125Gln
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 130 135
140Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr145 150 155 160Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr Ser Arg Leu Thr Val Asp
Lys Ser Arg Trp Gln Glu Gly Asn 195 200 205Val Phe Ser Cys Ser Val
Met His Glu Ala Leu His Asn His Tyr Thr 210 215 220Gln Lys Ser Leu
Ser Leu Ser Leu Gly Lys225 2306067PRTHomo sapiens 60Val Asp Lys Lys
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 20 25 30Phe Pro
Pro Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 35 40 45Val
Lys Phe Asn Trp Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 50 55
60Ala Pro Ile656163PRTHomo sapiens 61Val Asp Lys Thr Val Glu Arg
Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val Ala
Gly Pro Ser Val Phe Leu Phe Pro Pro Thr 20 25 30Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 35 40 45Trp Tyr Lys Cys
Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 50 55 606264PRTHomo
sapiens 62Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro
Ser Cys1 5 10 15Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro 20 25 30Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro
Glu Val Gln Phe 35 40 45Asn Trp Tyr Lys Cys Lys Val Ser Asn Lys Gly
Leu Pro Ser Ser Ile 50 55 606362PRTMus musculus 63Val Asp Lys Lys
Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile1 5 10 15Cys Thr Val
Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Thr Cys 20 25 30Val Val
Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 35 40 45Phe
Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 50 55
606468PRTMus musculus 64Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr
Ile Lys Pro Cys Pro1 5 10 15Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu
Gly Gly Pro Ser Val Phe 20 25 30Ile Phe Pro Pro Thr Cys Val Val Val
Asp Val Ser Glu Asp Asp Pro 35 40 45Asp Val Gln Ile Ser Trp Phe Lys
Cys Lys Val Asn Asn Lys Asp Leu 50 55 60Pro Ala Pro
Ile656564PRTHomo sapiens 65Val Asp Lys Arg Val Glu Ser Lys Tyr Gly
Pro Pro Cys Pro Ser Cys1 5 10 15Pro Ala Pro Glu Phe Leu Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro 20 25 30Thr Cys Val Val Val Asp Val Ser
Gln Glu Asp Pro Glu Val Gln Phe 35 40 45Asn Trp Tyr Lys Cys Lys Val
Ser Asn Lys Gly Leu Pro Ser Ser Ile 50 55 6066453PRTArtificial
SequenceSynthetic 66Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro Gly
Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly Gly
Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr Arg
Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg Leu
Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro
Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp Tyr
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120 125Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 130 135
140Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
Pro145 150 155 160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
Thr Ser Gly Val 165 170 175His Thr Phe Pro Ala Val Leu Gln Ser Ser
Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser Ser
Ser Leu Gly Thr Gln Thr Tyr Ile 195 200 205Cys Asn Val Asn His Lys
Pro Ser Asn Thr Lys Val Asp Lys Arg Val 210 215 220Glu Ser Lys Tyr
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val225 230 235 240Ala
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 245 250
255Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val
260 265 270Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
Gly Val 275 280 285Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Phe Asn Ser 290 295 300Thr Tyr Arg Val Val Ser Val Leu Thr Val
Val His Gln Asp Trp Leu305 310 315 320Asn Gly Lys Glu Tyr Lys Cys
Lys Val Ser Asn Lys Gly Leu Pro Ser 325 330 335Ser Ile Glu Lys Thr
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 340 345 350Gln Val Tyr
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 355 360 365Val
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 370 375
380Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
Thr385 390 395 400Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
Tyr Ser Lys Leu 405 410 415Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
Asn Val Phe Ser Cys Ser 420 425 430Val Met His Glu Ala Leu His Asn
His Tyr Thr Gln Lys Ser Leu Ser 435 440 445Leu Ser Leu Gly Lys
45067453PRTArtificial SequenceSynthetic 67Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25
30Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys
Phe 50 55 60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr
Ala Tyr65 70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala
Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn
Gly Val Cys Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu
Val Thr Val Ser Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe
Pro Leu Ala Pro Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly Thr Ala
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170
175His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
180 185 190Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
Tyr Ile 195 200 205Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val
Asp Lys Arg Val 210 215 220Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro
Cys Pro Ala Pro Pro Val225 230 235 240Ala Gly Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro Lys Asp Thr 245 250 255Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val Val Ala Val 260 265 270Ser Gln Glu
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 275 280 285Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 290 295
300Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
Leu305 310 315 320Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Gly Leu Pro Ser 325 330 335Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro 340 345 350Gln Val Tyr Thr Leu Pro Pro Ser
Gln Glu Glu Met Thr Lys Asn Gln 355 360 365Val Ser Leu Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 370 375 380Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr385 390 395 400Pro
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 405 410
415Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
420 425 430Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
Leu Ser 435 440 445Leu Ser Leu Gly Lys 45068453PRTArtificial
SequenceSynthetic 68Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro Gly
Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly Gly
Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr Arg
Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg Leu
Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro
Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp Tyr
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120 125Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 130 135
140Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
Pro145 150 155 160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
Thr Ser Gly Val 165 170 175His Thr Phe Pro Ala Val Leu Gln Ser Ser
Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser Ser
Ser Leu Gly Thr Gln Thr Tyr Ile 195 200 205Cys Asn Val Asn His Lys
Pro Ser Asn Thr Lys Val Asp Lys Arg Val 210 215 220Glu Ser Lys Tyr
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala225 230 235 240Leu
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 245 250
255Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
260 265 270Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
Gly Val 275 280 285Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Phe Asn Ser 290 295 300Thr Tyr Arg Val Val Ser Val Leu Thr Val
Leu His Gln Asp Trp Leu305 310 315 320Asn Gly Lys Ala Tyr Lys Cys
Lys Val Ser Asn Lys Gly Leu Pro Ser 325 330 335Ser Ile Glu Lys Thr
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 340 345 350Gln Val Tyr
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 355 360 365Val
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 370 375
380Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
Thr385 390 395 400Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
Tyr Ser Arg Leu 405 410 415Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
Asn Val Phe Ser Cys Ser 420 425 430Val Met His Glu Ala Leu His Asn
His Tyr Thr Gln Lys Ser Leu Ser 435 440 445Leu Ser Leu Gly Lys
45069453PRTArtificial SequenceSynthetic 69Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile
Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75
80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser
Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro Val Thr Val Ser
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200
205Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val
210 215 220Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro
Glu Ala225 230 235 240Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr 245 250 255Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp Val 260 265 270Ser Gln Glu Asp Pro Glu Val
Gln Phe Asn Trp Tyr Val Asp Gly Val 275 280 285Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 290 295 300Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu305 310 315
320Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
325 330 335Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
Glu Pro 340 345 350Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
Thr Lys Asn Gln 355 360 365Val Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala 370 375 380Val Glu Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr385 390 395 400Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 405 410 415Thr Val Asp
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 420 425 430Val
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 435 440
445Leu Ser Leu Gly Lys 4507067PRTHomo sapiens 70Val Asp Lys Lys Val
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 20 25 30Phe Pro Pro
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 35 40 45Val Lys
Phe Asn Trp Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 50 55 60Ala
Pro Ile657161PRTArtificial SequenceSynthetic 71Lys Val Glu Pro Lys
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu
Leu Leu Ser Val Phe Leu Phe Pro Pro Thr Cys Val 20 25 30Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 50 55
607263PRTArtificial SequenceSynthetic 72Lys Val Glu Pro Lys Ser Cys
Asp Lys Thr His Thr Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Leu Leu
Gly Pro Ser Val Phe Leu Phe Pro Pro Thr 20 25 30Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 35 40 45Trp Tyr Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 50 55
607362PRTArtificial SequenceSynthetic 73Lys Lys Val Glu Pro Lys Cys
Cys Val Glu Cys Pro Pro Cys Pro Ala1 5 10 15Pro Glu Leu Leu Gly Gly
Pro Ser Val Phe Leu Phe Pro Pro Thr Cys 20 25 30Val Val Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 35 40 45Tyr Lys Cys Lys
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 50 55 607462PRTArtificial
SequenceSynthetic 74Lys Lys Val Glu Pro Lys Tyr Gly Pro Pro Cys Pro
Pro Cys Pro Ala1 5 10 15Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro Thr Cys 20 25 30Val Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe Asn Trp 35 40 45Tyr Lys Cys Lys Val Ser Asn Lys Ala
Leu Pro Ala Pro Ile 50 55 607564PRTArtificial SequenceSynthetic
75Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys1
5 10 15Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro 20 25 30Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Glu
Lys Phe 35 40 45Asn Trp Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
Ala Pro Ile 50 55 607664PRTArtificial SequenceSynthetic 76Lys Val
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys1 5 10 15Pro
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 20 25
30Thr Cys Val Val Val Asp Val Glu His Glu Asp Pro Glu Val Lys Phe
35 40 45Asn Trp Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile 50 55 607764PRTArtificial SequenceSynthetic 77Lys Val Glu Pro
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys1 5 10 15Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 20 25 30Thr Cys
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 35 40 45Asn
Trp Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile 50 55
607864PRTArtificial SequenceSynthetic 78Lys Val Glu Pro Lys Ser Cys
Asp Lys Thr His Thr Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Leu Leu
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 20 25 30Thr Cys Val Val Val
Asp Val Glu His Glu Asp Pro Glu Val Lys Phe 35 40 45Asn Trp Tyr Lys
Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile 50 55
607961PRTArtificial SequenceSynthetic 79Lys Val Glu Pro Lys Ser Cys
Asp Lys Thr His Thr Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Leu Leu
Ser Val Phe Leu Phe Pro Pro Thr Cys Val 20 25 30Val Val Asp Val Ser
His Glu Asp Pro Glu Glu Lys Phe Asn Trp Tyr 35 40 45Lys Cys Lys Val
Ser Asn Lys Ala Leu Pro Ala Pro Ile 50 55 608061PRTArtificial
SequenceSynthetic 80Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Leu Leu Ser Val Phe Leu Phe
Pro Pro Thr Cys Val 20 25 30Val Val Asp Val Glu His Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr 35 40 45Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 50 55 608161PRTArtificial SequenceSynthetic 81Lys
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys1 5 10
15Pro Ala Pro Glu Leu Leu Ser Val Phe Leu Phe Pro Pro Thr Cys Val
20 25 30Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
Tyr 35 40 45Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile 50
55 608261PRTArtificial SequenceSynthetic 82Lys Val Glu Pro Lys Ser
Cys Asp Lys Thr His Thr Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Leu
Leu Ser Val Phe Leu Phe Pro Pro Thr Cys Val 20 25 30Val Val Asp Val
Glu His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45Lys Cys Lys
Val Ser Asn Lys Ala Phe Pro Ala Pro Ile 50 55 608363PRTArtificial
SequenceSynthetic 83Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Leu Leu Gly Pro Ser Val Phe
Leu Phe Pro Pro Thr 20 25 30Cys Val Val Val Asp Val Ser His Glu Asp
Pro Glu Glu Lys Phe Asn 35 40 45Trp Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile 50 55 608463PRTArtificial SequenceSynthetic
84Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys1
5 10 15Pro Ala Pro Glu Leu Leu Gly Pro Ser Val Phe Leu Phe Pro Pro
Thr 20 25 30Cys Val Val Val Asp Val Glu His Glu Asp Pro Glu Val Lys
Phe Asn 35 40 45Trp Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
Pro Ile 50 55 608563PRTArtificial SequenceSynthetic 85Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys1 5 10 15Pro Ala
Pro Glu Leu Leu Gly Pro Ser Val Phe Leu Phe Pro Pro Thr 20 25 30Cys
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 35 40
45Trp Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile 50 55
608663PRTArtificial SequenceSynthetic 86Lys Val Glu Pro Lys Ser Cys
Asp Lys Thr His Thr Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Leu Leu
Gly Pro Ser Val Phe Leu Phe Pro Pro Thr 20 25 30Cys Val Val Val Asp
Val Glu His Glu Asp Pro Glu Val Lys Phe Asn 35
40 45Trp Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile 50
55 608765PRTArtificial SequenceSynthetic 87Lys Lys Val Glu Pro Lys
Ser Cys Asp Lys Thr His Thr Cys Pro Pro1 5 10 15Cys Pro Ala Pro Glu
Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 20 25 30Pro Thr Cys Val
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 35 40 45Phe Asn Trp
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 50 55
60Ile658865PRTArtificial SequenceSynthetic 88Lys Lys Val Glu Pro
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro1 5 10 15Cys Pro Ala Pro
Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 20 25 30Pro Thr Cys
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 35 40 45Phe Asn
Trp Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro 50 55
60Ile658963PRTHomo sapiens 89Val Asp Lys Thr Val Glu Arg Lys Cys
Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val Ala Gly Pro
Ser Val Phe Leu Phe Pro Pro Thr 20 25 30Cys Val Val Val Asp Val Ser
His Glu Asp Pro Glu Val Gln Phe Asn 35 40 45Trp Tyr Lys Cys Lys Val
Ser Asn Lys Gly Leu Pro Ala Pro Ile 50 55 609058PRTArtificial
SequenceSynthetic 90Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro
Cys Pro Ala Pro1 5 10 15Pro Val Ala Ser Val Phe Leu Phe Pro Pro Thr
Cys Val Val Val Asp 20 25 30Val Ser His Glu Asp Pro Glu Val Gln Phe
Asn Trp Tyr Lys Cys Lys 35 40 45Val Ser Asn Lys Gly Leu Pro Ala Pro
Ile 50 559164PRTArtificial SequenceSynthetic 91Lys Thr Val Glu Arg
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro1 5 10 15Cys Pro Ala Pro
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 20 25 30Thr Cys Val
Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 35 40 45Asn Trp
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 50 55
609261PRTArtificial SequenceSynthetic 92Thr Val Glu Arg Lys Cys Cys
Val Glu Cys Pro Pro Cys Pro Ala Pro1 5 10 15Pro Phe Leu Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro Thr Cys Val 20 25 30Val Val Asp Val Ser
His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 35 40 45Lys Cys Lys Val
Ser Asn Lys Gly Leu Pro Ala Pro Ile 50 55 609361PRTArtificial
SequenceSynthetic 93Lys Thr Val Glu Arg Lys Tyr Gly Pro Pro Cys Pro
Pro Cys Pro Ala1 5 10 15Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe
Pro Pro Thr Cys Val 20 25 30Val Val Asp Val Ser His Glu Asp Pro Glu
Val Gln Phe Asn Trp Tyr 35 40 45Lys Cys Lys Val Ser Asn Lys Gly Leu
Pro Ala Pro Ile 50 55 609460PRTArtificial SequenceSynthetic 94Thr
Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro1 5 10
15Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Thr Cys Val Val
20 25 30Val Asp Val Ser His Glu Asp Pro Glu Glu Gln Phe Asn Trp Tyr
Lys 35 40 45Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 50 55
609560PRTArtificial SequenceSynthetic 95Thr Val Glu Arg Lys Cys Cys
Val Glu Cys Pro Pro Cys Pro Ala Pro1 5 10 15Pro Val Ala Gly Pro Ser
Val Phe Leu Phe Pro Pro Thr Cys Val Val 20 25 30Val Asp Val Glu His
Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Lys 35 40 45Cys Lys Val Ser
Asn Lys Gly Leu Pro Ala Pro Ile 50 55 609660PRTArtificial
SequenceSynthetic 96Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro
Cys Pro Ala Pro1 5 10 15Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro
Pro Thr Cys Val Val 20 25 30Val Asp Val Ser His Glu Asp Pro Glu Val
Gln Phe Asn Trp Tyr Lys 35 40 45Cys Lys Val Ser Asn Lys Gly Phe Pro
Ala Pro Ile 50 55 609760PRTArtificial SequenceSynthetic 97Thr Val
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro1 5 10 15Pro
Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Thr Cys Val Val 20 25
30Val Asp Val Glu His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Lys
35 40 45Cys Lys Val Ser Asn Lys Gly Phe Pro Ala Pro Ile 50 55
609858PRTArtificial SequenceSynthetic 98Thr Val Glu Arg Lys Cys Cys
Val Glu Cys Pro Pro Cys Pro Ala Pro1 5 10 15Glu Val Ser Ser Val Phe
Leu Phe Pro Pro Thr Cys Val Val Val Asp 20 25 30Val Ser His Glu Asp
Pro Glu Val Gln Phe Asn Trp Tyr Lys Cys Lys 35 40 45Val Ser Asn Lys
Gly Phe Pro Ala Pro Ile 50 559958PRTArtificial SequenceSynthetic
99Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro1
5 10 15Pro Val Ala Ser Val Phe Leu Phe Pro Pro Thr Cys Val Val Val
Asp 20 25 30Val Ser His Glu Asp Pro Glu Glu Gln Phe Asn Trp Tyr Lys
Cys Lys 35 40 45Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 50
5510058PRTArtificial SequenceSynthetic 100Thr Val Glu Arg Lys Cys
Cys Val Glu Cys Pro Pro Cys Pro Ala Pro1 5 10 15Pro Val Ala Ser Val
Phe Leu Phe Pro Pro Thr Cys Val Val Val Asp 20 25 30Val Glu His Glu
Asp Pro Glu Val Gln Phe Asn Trp Tyr Lys Cys Lys 35 40 45Val Ser Asn
Lys Gly Leu Pro Ala Pro Ile 50 5510158PRTArtificial
SequenceSynthetic 101Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro
Pro Cys Pro Ala Pro1 5 10 15Pro Val Ala Ser Val Phe Leu Phe Pro Pro
Thr Cys Val Val Val Asp 20 25 30Val Ser His Glu Asp Pro Glu Val Gln
Phe Asn Trp Tyr Lys Cys Lys 35 40 45Val Ser Asn Lys Gly Phe Pro Ala
Pro Ile 50 5510258PRTArtificial SequenceSynthetic 102Thr Val Glu
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro1 5 10 15Pro Val
Ala Ser Val Phe Leu Phe Pro Pro Thr Cys Val Val Val Asp 20 25 30Val
Glu His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Lys Cys Lys 35 40
45Val Ser Asn Lys Gly Phe Pro Ala Pro Ile 50 5510359PRTArtificial
SequenceSynthetic 103Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro
Pro Cys Pro Ala Pro1 5 10 15Pro Val Ala Pro Ser Val Phe Leu Phe Pro
Pro Thr Cys Val Val Val 20 25 30Asp Val Ser His Glu Asp Pro Glu Val
Gln Phe Asn Trp Tyr Lys Cys 35 40 45Lys Val Ser Asn Lys Gly Leu Pro
Ala Pro Ile 50 5510459PRTArtificial SequenceSynthetic 104Thr Val
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro1 5 10 15Pro
Val Ala Pro Ser Val Phe Leu Phe Pro Pro Thr Cys Val Val Val 20 25
30Asp Val Glu His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Lys Cys
35 40 45Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 50
5510559PRTArtificial SequenceSynthetic 105Thr Val Glu Arg Lys Cys
Cys Val Glu Cys Pro Pro Cys Pro Ala Pro1 5 10 15Pro Val Ala Pro Ser
Val Phe Leu Phe Pro Pro Thr Cys Val Val Val 20 25 30Asp Val Ser His
Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Lys Cys 35 40 45Lys Val Ser
Asn Lys Gly Phe Pro Ala Pro Ile 50 5510659PRTArtificial
SequenceSynthetic 106Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys
Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe Leu Ser Val Phe Leu Phe Pro
Pro Thr Cys Val Val Val 20 25 30Asp Val Ser Gln Glu Asp Pro Glu Val
Gln Phe Asn Trp Tyr Lys Cys 35 40 45Lys Val Ser Asn Lys Gly Leu Pro
Ser Ser Ile 50 5510765PRTArtificial SequenceSynthetic 107Lys Arg
Val Glu Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro1 5 10 15Cys
Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 20 25
30Pro Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln
35 40 45Phe Asn Trp Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
Ser 50 55 60Ile6510861PRTArtificial SequenceSynthetic 108Lys Arg
Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1 5 10 15Pro
Glu Phe Leu Gly Pro Ser Val Phe Leu Phe Pro Pro Thr Cys Val 20 25
30Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
35 40 45Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 50 55
6010962PRTArtificial SequenceSynthetic 109Lys Arg Val Glu Ser Lys
Cys Cys Val Glu Cys Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Thr Cys 20 25 30Val Val Val Asp
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 35 40 45Tyr Lys Cys
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 50 55
6011062PRTArtificial SequenceSynthetic 110Lys Arg Val Glu Ser Lys
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Thr Cys 20 25 30Val Val Val Asp
Val Ser Gln Glu Asp Pro Glu Glu Gln Phe Asn Trp 35 40 45Tyr Lys Cys
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 50 55
6011159PRTArtificial SequenceSynthetic 111Lys Arg Val Glu Ser Lys
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe Leu Ser
Val Phe Leu Phe Pro Pro Thr Cys Val Val Val 20 25 30Asp Val Ser Gln
Glu Asp Pro Glu Glu Gln Phe Asn Trp Tyr Lys Cys 35 40 45Lys Val Ser
Asn Lys Gly Leu Pro Ser Ser Ile 50 5511261PRTArtificial
SequenceSynthetic 112Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys
Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe Leu Gly Pro Ser Val Phe Leu
Phe Pro Pro Thr Cys Val 20 25 30Val Val Asp Val Ser Gln Glu Asp Pro
Glu Glu Gln Phe Asn Trp Tyr 35 40 45Lys Cys Lys Val Ser Asn Lys Gly
Leu Pro Ser Ser Ile 50 55 6011362PRTArtificial SequenceSynthetic
113Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1
5 10 15Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Thr
Cys 20 25 30Val Val Val Asp Val Glu Gln Glu Asp Pro Glu Val Gln Phe
Asn Trp 35 40 45Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser
Ile 50 55 6011462PRTArtificial SequenceSynthetic 114Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Thr Cys 20 25 30Val Val
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 35 40 45Tyr
Lys Cys Lys Val Ser Asn Lys Gly Phe Pro Ser Ser Ile 50 55
6011562PRTArtificial SequenceSynthetic 115Lys Arg Val Glu Ser Lys
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Thr Cys 20 25 30Val Val Val Asp
Val Glu Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 35 40 45Tyr Lys Cys
Lys Val Ser Asn Lys Gly Phe Pro Ser Ser Ile 50 55
6011659PRTArtificial SequenceSynthetic 116Lys Arg Val Glu Ser Lys
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1 5 10 15Pro Glu Val Ser Ser
Val Phe Leu Phe Pro Pro Thr Cys Val Val Val 20 25 30Asp Val Ser Gln
Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Lys Cys 35 40 45Lys Val Ser
Asn Lys Gly Phe Pro Ser Ser Ile 50 5511759PRTArtificial
SequenceSynthetic 117Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys
Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe Leu Ser Val Phe Leu Phe Pro
Pro Thr Cys Val Val Val 20 25 30Asp Val Ser Gln Glu Asp Pro Glu Glu
Gln Phe Asn Trp Tyr Lys Cys 35 40 45Lys Val Ser Asn Lys Gly Leu Pro
Ser Ser Ile 50 5511859PRTArtificial SequenceSynthetic 118Lys Arg
Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1 5 10 15Pro
Glu Phe Leu Ser Val Phe Leu Phe Pro Pro Thr Cys Val Val Val 20 25
30Asp Val Glu Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Lys Cys
35 40 45Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 50
5511959PRTArtificial SequenceSynthetic 119Lys Arg Val Glu Ser Lys
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe Leu Ser
Val Phe Leu Phe Pro Pro Thr Cys Val Val Val 20 25 30Asp Val Ser Gln
Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Lys Cys 35 40 45Lys Val Ser
Asn Lys Gly Phe Pro Ser Ser Ile 50 5512059PRTArtificial
SequenceSynthetic 120Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys
Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe Leu Ser Val Phe Leu Phe Pro
Pro Thr Cys Val Val Val 20 25 30Asp Val Glu Gln Glu Asp Pro Glu Val
Gln Phe Asn Trp Tyr Lys Cys 35 40 45Lys Val Ser Asn Lys Gly Phe Pro
Ser Ser Ile 50 5512160PRTArtificial SequenceSynthetic 121Lys Arg
Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1 5 10 15Pro
Glu Phe Leu Gly Ser Val Phe Leu Phe Pro Pro Thr Cys Val Val 20 25
30Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Lys
35 40 45Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 50 55
6012261PRTArtificial SequenceSynthetic 122Lys Arg Val Glu Ser Lys
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe Leu Gly
Pro Ser Val Phe Leu Phe Pro Pro Thr Cys Val 20 25 30Val Val Asp Val
Ser Gln Glu Asp Pro Glu Glu Gln Phe Asn Trp Tyr 35 40 45Lys Cys Lys
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 50 55 6012361PRTArtificial
SequenceSynthetic 123Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys
Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe Leu Gly Pro Ser Val Phe Leu
Phe Pro Pro Thr Cys Val 20 25 30Val Val Asp Val Glu Gln Glu Asp Pro
Glu Val Gln Phe Asn Trp Tyr 35 40 45Lys Cys Lys Val Ser Asn Lys Gly
Leu Pro Ser Ser Ile 50 55 6012461PRTArtificial SequenceSynthetic
124Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1
5 10 15Pro Glu Phe Leu Gly Pro Ser Val Phe Leu Phe Pro Pro Thr Cys
Val 20 25 30Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
Trp Tyr 35
40 45Lys Cys Lys Val Ser Asn Lys Gly Phe Pro Ser Ser Ile 50 55
6012561PRTArtificial SequenceSynthetic 125Lys Arg Val Glu Ser Lys
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe Leu Gly
Pro Ser Val Phe Leu Phe Pro Pro Thr Cys Val 20 25 30Val Val Asp Val
Glu Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 35 40 45Lys Cys Lys
Val Ser Asn Lys Gly Phe Pro Ser Ser Ile 50 55 6012660PRTArtificial
SequenceSynthetic 126Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys
Pro Pro Cys Pro Ala1 5 10 15Pro Glu Phe Leu Pro Ser Val Phe Leu Phe
Pro Pro Thr Cys Val Val 20 25 30Val Asp Val Ser Gln Glu Asp Pro Glu
Val Gln Phe Asn Trp Tyr Lys 35 40 45Cys Lys Val Ser Asn Lys Gly Leu
Pro Ser Ser Ile 50 55 6012762PRTArtificial SequenceSynthetic 127Lys
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala1 5 10
15Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Thr Cys
20 25 30Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
Trp 35 40 45Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile
50 55 60128126PRTArtificial SequenceSynthetic 128Gln Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly
Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55
60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65
70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys
Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
Ser Ser 115 120 125129107PRTArtificial SequenceSynthetic 129Asp Ile
Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly1 5 10 15Asp
Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp 20 25
30Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
35 40 45Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser
Gly 50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
Gln Pro65 70 75 80Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn
Ile Phe Pro Leu 85 90 95Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105130113PRTArtificial SequenceSynthetic 130Glu Val Gln Leu Gln
Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala1 5 10 15Ser Val Lys Ile
Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30Asn Met Asp
Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 35 40 45Gly Asp
Ile Asn Pro Asn Asn Asp Ile Ser Ile Tyr Asn Gln Lys Phe 50 55 60Arg
Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr65 70 75
80Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
Ser 100 105 110Ala131112PRTArtificial SequenceSynthetic 131Asp Val
Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Ile Gly1 5 10 15Asp
Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 20 25
30Tyr Gly Asn Thr Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser
35 40 45Pro Lys Leu Leu Ile Tyr Asn Val Ser Asn Arg Phe Ser Gly Val
Pro 50 55 60Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Arg Ile65 70 75 80Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe
Cys Ser Gln Gly 85 90 95Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile Lys 100 105 110132120PRTArtificial
SequenceSynthetic 132Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu
Val Arg Pro Gly Ala1 5 10 15Ser Val Lys Leu Ser Cys Lys Ala Ser Gly
Tyr Ile Phe Ile Ser Tyr 20 25 30Trp Ile His Trp Leu Lys Gln Arg Pro
Gly Arg Gly Leu Glu Trp Ile 35 40 45Gly Arg Ile Asp Pro Asn Asn Gly
Gly Thr Lys Tyr Asn Glu Lys Phe 50 55 60Arg Tyr Lys Ala Ser Leu Thr
Val Asp Lys Ser Ser Ser Thr Ala Tyr65 70 75 80Met Gln Leu Ser Ser
Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95Thr Lys Gly Val
Ile Thr Thr Leu Val Ala Gly Asp Tyr Trp Gly Gln 100 105 110Gly Thr
Thr Leu Thr Val Ser Ser 115 120133107PRTArtificial
SequenceSynthetic 133Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu
Ser Ala Ser Leu Gly1 5 10 15Glu Thr Val Ser Ile Glu Cys Leu Ala Ser
Glu Asp Ile Ser Asn Asp 20 25 30Leu Ala Trp Tyr Gln Gln Lys Ser Gly
Lys Ser Pro Gln Leu Leu Ile 35 40 45Tyr Phe Val Asp Arg Leu Leu Asp
Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Gly Thr Arg His
Ser Leu Lys Ile Ser Gly Met Gln Pro65 70 75 80Glu Asp Glu Ala Asp
Tyr Phe Cys Gln Gln Ser Tyr Lys Tyr Pro Pro 85 90 95Thr Phe Gly Gly
Gly Thr Lys Leu Glu Leu Lys 100 105134123PRTArtificial
SequenceSynthetic 134Glu Val Gln Ile Leu Glu Thr Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly
Phe Asn Phe Asn Asp Ser 20 25 30Phe Met Asn Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45Ala Gln Ile Arg Asn Lys Asn Tyr
Asn Tyr Ala Thr Tyr Tyr Thr Glu 50 55 60Ser Leu Glu Gly Arg Val Thr
Ile Ser Arg Asp Asp Ser Lys Ser Arg65 70 75 80Val Tyr Leu Gln Val
Ser Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr 85 90 95Tyr Cys Thr Ser
Tyr Tyr Tyr Asp Gly Phe Ala Asp Tyr Phe Asp Tyr 100 105 110Trp Gly
Gln Gly Val Met Val Thr Val Ser Ser 115 120135108PRTArtificial
SequenceSynthetic 135Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met
Ala Ala Ser Pro Gly1 5 10 15Glu Lys Ile Thr Ile Thr Cys Ser Ala Ser
Ser Ser Ile Ser Ser Asn 20 25 30Tyr Leu His Trp Tyr Gln Gln Lys Pro
Gly Ser Ser Pro Lys Val Leu 35 40 45Ile Tyr Arg Thr Ser Asn Leu Ala
Ser Gly Val Pro Val Arg Phe Ser 50 55 60Gly Ser Gly Ser Gly Thr Ser
Tyr Ser Leu Thr Ile Gly Thr Met Glu65 70 75 80Ala Glu Asp Val Ala
Thr Tyr Tyr Cys Gln Gln Gly Ser Ser Ile Pro 85 90 95Tyr Thr Phe Gly
Gly Gly Thr Lys Leu Glu Ile Lys 100 105136122PRTArtificial
SequenceSynthetic 136Glu Val His Leu Val Glu Ser Gly Gly Gly Leu
Val Gln Pro Gly Arg1 5 10 15Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly
Phe Thr Phe Thr Asn Tyr 20 25 30Gly Leu His Trp Ile Arg Gln Ala Pro
Thr Lys Gly Leu Glu Trp Val 35 40 45Ala Ser Ile Ser Pro Ser Gly Gly
Val Thr Tyr Tyr Arg Asp Ser Val 50 55 60Lys Gly Arg Phe Thr Ile Ser
Arg Asp Asn Gly Lys Thr Thr Leu His65 70 75 80Leu Gln Met Asp Ser
Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 85 90 95Ala Leu Pro Phe
Leu Gly Trp Gly Gly Ala Asn Trp Ile Ala His Trp 100 105 110Gly Gln
Gly Thr Leu Val Thr Val Ser Ser 115 120137106PRTArtificial
SequenceSynthetic 137Asp Ile Lys Val Thr Gln Ser Pro Ser Phe Leu
Ser Ala Ser Val Gly1 5 10 15Asp Arg Ala Thr Ile Asn Cys Lys Ala Ser
Gln Asn Leu Asn Lys Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Pro Gly
Glu Pro Pro Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asp Asn Leu Tyr Thr
Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly Ser Val Ala Asp Phe
Thr Leu Thr Ile Ser Gly Leu Gln Pro65 70 75 80Glu Asp Val Ala Thr
Tyr Phe Cys Met Gln His Asn Val Arg Arg Thr 85 90 95Phe Gly Gly Gly
Thr Lys Leu Glu Leu Lys 100 105138123PRTArtificial
SequenceSynthetic 138Glu Val His Ile Leu Glu Thr Gly Gly Gly Leu
Val Lys Pro Gly Gly1 5 10 15Ser Leu Gly Leu Ser Cys Thr Thr Ser Gly
Phe Asn Phe Asn Asp Tyr 20 25 30Phe Met Asn Trp Val Arg Gln Ala Pro
Gly Lys Gly Leu Glu Trp Val 35 40 45Ala Gln Ile Arg Asn Gly Asn Tyr
Asp Tyr Ala Ala Tyr Tyr Ala Glu 50 55 60Ser Leu Glu Gly Arg Val Thr
Ile Ser Arg Asp Asp Ser Lys Ser Ser65 70 75 80Val Asn Leu Gln Val
Ser Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 85 90 95Tyr Cys Thr Ser
Tyr Tyr Tyr Asp Gly His Phe Asp Tyr Phe Asp Asn 100 105 110Trp Gly
His Gly Val Met Val Thr Val Ser Ser 115 120139106PRTArtificial
SequenceSynthetic 139Asp Ile Lys Met Thr Gln Ser Pro Ser Phe Leu
Ser Ala Ser Val Gly1 5 10 15Asp Ser Val Thr Phe Thr Cys Lys Ala Ser
Gln Asn Ile Tyr Ile Tyr 20 25 30Leu Asn Trp Tyr Gln Gln Lys Phe Gly
Glu Ala Pro Lys Leu Leu Ile 35 40 45Tyr Asn Thr Asn Asn Leu Gln Thr
Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60Ser Glu Ser Gly Thr Val Phe
Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75 80Glu Asp Val Ala Thr
Tyr Phe Cys Leu Gln His Ser Ser Arg Arg Thr 85 90 95Phe Gly Gly Gly
Thr Lys Leu Glu Leu Lys 100 105140215PRTHomo sapiens 140His Arg Arg
Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp1 5 10 15Phe Val
Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser 20 25 30Leu
Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe 35 40
45Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser
50 55 60Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His
Val65 70 75 80Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln
Trp Ala Glu 85 90 95Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr
Leu Glu Asn Gly 100 105 110Lys Gln Leu Thr Val Lys Arg Gln Gly Leu
Tyr Tyr Ile Tyr Ala Gln 115 120 125Val Thr Phe Cys Ser Asn Arg Glu
Ala Ser Ser Gln Ala Pro Phe Ile 130 135 140Ala Ser Leu Cys Leu Lys
Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu145 150 155 160Arg Ala Ala
Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser 165 170 175Ile
His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe 180 185
190Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr
195 200 205Ser Phe Gly Leu Leu Lys Leu 210 215141277PRTHomo sapiens
141Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr1
5 10 15Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr
Leu 20 25 30Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys
Leu Val 35 40 45Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro
Cys Gly Glu 50 55 60Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His
Cys His Gln His65 70 75 80Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg
Val Gln Gln Lys Gly Thr 85 90 95Ser Glu Thr Asp Thr Ile Cys Thr Cys
Glu Glu Gly Trp His Cys Thr 100 105 110Ser Glu Ala Cys Glu Ser Cys
Val Leu His Arg Ser Cys Ser Pro Gly 115 120 125Phe Gly Val Lys Gln
Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 130 135 140Pro Cys Pro
Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys145 150 155
160Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln
165 170 175Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp
Arg Leu 180 185 190Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile
Leu Phe Ala Ile 195 200 205Leu Leu Val Leu Val Phe Ile Lys Lys Val
Ala Lys Lys Pro Thr Asn 210 215 220Lys Ala Pro His Pro Lys Gln Glu
Pro Gln Glu Ile Asn Phe Pro Asp225 230 235 240Asp Leu Pro Gly Ser
Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 245 250 255Gly Cys Gln
Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 260 265 270Val
Gln Glu Arg Gln 275142232PRTMus musculus 142Val Asp Lys Lys Ile Val
Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile1 5 10 15Cys Thr Val Pro Glu
Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro 20 25 30Lys Asp Val Leu
Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val 35 40 45Val Asp Ile
Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val 50 55 60Asp Asp
Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln65 70 75
80Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln
85 90 95Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala
Ala 100 105 110Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys
Gly Arg Pro 115 120 125Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro
Lys Glu Gln Met Ala 130 135 140Lys Asp Lys Val Ser Leu Thr Cys Met
Ile Thr Asp Phe Phe Pro Glu145 150 155 160Asp Ile Thr Val Glu Trp
Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr 165 170 175Lys Asn Thr Gln
Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr 180 185 190Ser Lys
Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe 195 200
205Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys
210 215 220Ser Leu Ser His Ser Pro Gly Lys225 230143238PRTMus
musculus 143Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro
Cys Pro1 5 10 15Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro
Ser Val Phe 20 25 30Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile
Ser Leu Ser Pro 35 40 45Ile Val Thr Cys Val Val Val Asp Val Ser Glu
Asp Asp Pro Asp Val 50 55 60Gln Ile Ser Trp Phe Val Asn Asn Val Glu
Val His Thr Ala Gln Thr65 70 75 80Gln Thr His Arg Glu Asp Tyr Asn
Ser Thr Leu Arg Val Val Ser Ala 85
90 95Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys
Cys 100 105 110Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg
Thr Ile Ser 115 120 125Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val
Tyr Val Leu Pro Pro 130 135 140Pro Glu Glu Glu Met Thr Lys Lys Gln
Val Thr Leu Thr Cys Met Val145 150 155 160Thr Asp Phe Met Pro Glu
Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 165 170 175Lys Thr Glu Leu
Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 180 185 190Gly Ser
Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 195 200
205Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His
210 215 220Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly
Lys225 230 235144232PRTArtificial SequenceSynthetic 144Val Asp Lys
Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile1 5 10 15Cys Thr
Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro 20 25 30Lys
Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val 35 40
45Val Ala Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val
50 55 60Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu
Gln65 70 75 80Phe Ala Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile
Met His Gln 85 90 95Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val
Asn Ser Ala Ala 100 105 110Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser
Lys Thr Lys Gly Arg Pro 115 120 125Lys Ala Pro Gln Val Tyr Thr Ile
Pro Pro Pro Lys Glu Gln Met Ala 130 135 140Lys Asp Lys Val Ser Leu
Thr Cys Met Ile Thr Asp Phe Phe Pro Glu145 150 155 160Asp Ile Thr
Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr 165 170 175Lys
Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr 180 185
190Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe
195 200 205Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr
Glu Lys 210 215 220Ser Leu Ser His Ser Pro Gly Lys225
230145238PRTArtificial SequenceSynthetic 145Val Asp Lys Lys Ile Glu
Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro1 5 10 15Pro Cys Lys Cys Pro
Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 20 25 30Ile Phe Pro Pro
Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 35 40 45Ile Val Thr
Cys Val Val Val Ala Val Ser Glu Asp Asp Pro Asp Val 50 55 60Gln Ile
Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr65 70 75
80Gln Thr His Arg Glu Asp Tyr Ala Ser Thr Leu Arg Val Val Ser Ala
85 90 95Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys
Cys 100 105 110Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg
Thr Ile Ser 115 120 125Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val
Tyr Val Leu Pro Pro 130 135 140Pro Glu Glu Glu Met Thr Lys Lys Gln
Val Thr Leu Thr Cys Met Val145 150 155 160Thr Asp Phe Met Pro Glu
Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 165 170 175Lys Thr Glu Leu
Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 180 185 190Gly Ser
Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 195 200
205Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His
210 215 220Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly
Lys225 230 235146214PRTArtificial SequenceSynthetic 146Asp Ile Gln
Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly1 5 10 15Asp Arg
Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp 20 25 30Leu
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40
45Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro65 70 75 80Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile
Phe Pro Leu 85 90 95Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
Thr Val Ala Ala 100 105 110Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
Glu Gln Leu Lys Ser Gly 115 120 125Thr Ala Ser Val Val Cys Leu Leu
Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140Lys Val Gln Trp Lys Val
Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln145 150 155 160Glu Ser Val
Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175Ser
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185
190Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
195 200 205Phe Asn Arg Gly Glu Cys 210147455PRTArtificial
SequenceSynthetic 147Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly
Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly
Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr
Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg
Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln
Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120
125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
130 135 140Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro145 150 155 160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200 205Cys Asn Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 210 215 220Glu Pro Lys
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala225 230 235
240Pro Glu Leu Leu Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
245 250 255Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
Val Val 260 265 270Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
Trp Tyr Val Asp 275 280 285Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu Glu Gln Tyr 290 295 300Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu His Gln Asp305 310 315 320Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 325 330 335Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 340 345 350Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 355 360
365Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
370 375 380Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
Tyr Lys385 390 395 400Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu Tyr Ser 405 410 415Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val Phe Ser 420 425 430Cys Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr Gln Lys Ser 435 440 445Leu Ser Leu Ser Pro
Gly Lys 450 455148455PRTArtificial SequenceSynthetic 148Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val
Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr
Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40
45Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala
Tyr65 70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val
Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly
Val Cys Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
Thr Val Ser Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe Pro
Leu Ala Pro Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly Thr Ala Ala
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro Val
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185
190Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
195 200 205Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
Lys Val 210 215 220Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro
Pro Cys Pro Ala225 230 235 240Pro Glu Leu Leu Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro Lys 245 250 255Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val Val 260 265 270Asp Val Glu His Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 275 280 285Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 290 295 300Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp305 310
315 320Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
Leu 325 330 335Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro Arg 340 345 350Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Glu Glu Met Thr Lys 355 360 365Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp 370 375 380Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys385 390 395 400Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 405 410 415Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 420 425
430Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
435 440 445Leu Ser Leu Ser Pro Gly Lys 450 455149450PRTArtificial
SequenceSynthetic 149Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly
Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly
Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr
Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg
Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln
Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120
125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr
130 135 140Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro145 150 155 160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser
Ser Asn Phe Gly Thr Gln Thr Tyr Thr 195 200 205Cys Asn Val Asp His
Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val 210 215 220Glu Arg Lys
Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val225 230 235
240Ala Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
245 250 255Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
His Glu 260 265 270Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
Val Glu Val His 275 280 285Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
Phe Asn Ser Thr Phe Arg 290 295 300Val Val Ser Val Leu Thr Val Val
His Gln Asp Trp Leu Asn Gly Lys305 310 315 320Glu Tyr Lys Cys Lys
Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 325 330 335Lys Thr Ile
Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350Thr
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 355 360
365Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
370 375 380Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
Pro Met385 390 395 400Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
Lys Leu Thr Val Asp 405 410 415Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser Cys Ser Val Met His 420 425 430Glu Ala Leu His Asn His Tyr
Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445Gly Lys
450150450PRTArtificial SequenceSynthetic 150Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile
Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75
80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser
Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Cys Ser Arg Ser Thr 130 135 140Ser Glu Ser Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro Val Thr Val Ser
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val
Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr 195 200
205Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val
210 215 220Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
Pro Val225 230 235 240Ala Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
Asp Thr Leu Met Ile 245 250 255Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Glu His Glu 260 265 270Asp
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280
285Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg
290 295 300Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn
Gly Lys305 310 315 320Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Phe
Pro Ala Pro Ile Glu 325 330 335Lys Thr Ile Ser Lys Thr Lys Gly Gln
Pro Arg Glu Pro Gln Val Tyr 340 345 350Thr Leu Pro Pro Ser Arg Glu
Glu Met Thr Lys Asn Gln Val Ser Leu 355 360 365Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met385 390 395
400Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
405 410 415Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
Met His 420 425 430Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser Pro 435 440 445Gly Lys 450151451PRTArtificial
SequenceSynthetic 151Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly
Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly
Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr
Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg
Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln
Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120
125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr
130 135 140Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro145 150 155 160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser
Ser Asn Phe Gly Thr Gln Thr Tyr Thr 195 200 205Cys Asn Val Asp His
Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val 210 215 220Glu Arg Lys
Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val225 230 235
240Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
245 250 255Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
Ser His 260 265 270Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
Gly Val Glu Val 275 280 285His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Phe Asn Ser Thr Phe 290 295 300Arg Val Val Ser Val Leu Thr Val
Val His Gln Asp Trp Leu Asn Gly305 310 315 320Lys Glu Tyr Lys Cys
Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 325 330 335Glu Lys Thr
Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 340 345 350Tyr
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 355 360
365Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
370 375 380Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
Pro Pro385 390 395 400Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val 405 410 415Asp Lys Ser Arg Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met 420 425 430His Glu Ala Leu His Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser 435 440 445Pro Gly Lys
450152452PRTArtificial SequenceSynthetic 152Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile
Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75
80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser
Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Cys Ser Arg Ser Thr 130 135 140Ser Glu Ser Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro Val Thr Val Ser
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 195 200
205Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val
210 215 220Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro
Glu Phe225 230 235 240Leu Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
Pro Lys Asp Thr Leu 245 250 255Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val Val Val Asp Val Ser 260 265 270Gln Glu Asp Pro Glu Val Gln
Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 290 295 300Tyr Arg Val
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn305 310 315
320Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser
325 330 335Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln 340 345 350Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
Lys Asn Gln Val 355 360 365Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile Ala Val 370 375 380Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr Thr Pro385 390 395 400Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 405 410 415Val Asp Lys
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 420 425 430Met
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440
445Ser Leu Gly Lys 450153451PRTArtificial SequenceSynthetic 153Gln
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10
15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln
Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser
Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr
Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr
Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr
Leu Val Thr Val Ser Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 130 135 140Ser Glu Ser Thr
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170
175His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
180 185 190Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
Tyr Thr 195 200 205Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val
Asp Lys Arg Val 210 215 220Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro
Cys Pro Ala Pro Glu Phe225 230 235 240Leu Gly Ser Val Phe Leu Phe
Pro Pro Lys Pro Lys Asp Thr Leu Met 245 250 255Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val Val Asp Val Ser Gln 260 265 270Glu Asp Pro
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 275 280 285His
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 290 295
300Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
Gly305 310 315 320Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
Pro Ser Ser Ile 325 330 335Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 340 345 350Tyr Thr Leu Pro Pro Ser Gln Glu
Glu Met Thr Lys Asn Gln Val Ser 355 360 365Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 370 375 380Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro385 390 395 400Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 405 410
415Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met
420 425 430His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser 435 440 445Leu Gly Lys 450154451PRTArtificial
SequenceSynthetic 154Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly
Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly
Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr
Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg
Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln
Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120
125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr
130 135 140Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro145 150 155 160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Lys Thr Tyr Thr 195 200 205Cys Asn Val Asp His
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 210 215 220Glu Ser Lys
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe225 230 235
240Leu Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
245 250 255Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
Ser Gln 260 265 270Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
Gly Val Glu Val 275 280 285His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Phe Asn Ser Thr Tyr 290 295 300Arg Val Val Ser Val Leu Thr Val
Leu His Gln Asp Trp Leu Asn Gly305 310 315 320Lys Glu Tyr Lys Cys
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 325 330 335Glu Lys Thr
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 340 345 350Tyr
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 355 360
365Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
370 375 380Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
Pro Pro385 390 395 400Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
Ser Arg Leu Thr Val 405 410 415Asp Lys Ser Arg Trp Gln Glu Gly Asn
Val Phe Ser Cys Ser Val Met 420 425 430His Glu Ala Leu His Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser 435 440 445Leu Gly Lys
450155214PRTArtificial SequenceSynthetic 155Asp Ile Gln Met Thr Gln
Ser Pro Ser Ser Val Ser Ala Ser Val Gly1 5 10 15Asp Arg Val Thr Ile
Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp 20 25 30Leu Ala Trp Tyr
Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45Tyr Thr Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60Ser Gly
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro65 70 75
80Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu
85 90 95Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala
Ala 100 105 110Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu
Thr Ser Gly 115 120 125Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe
Tyr Pro Lys Asp Ile 130 135 140Asn Val Lys Trp Lys Ile Asp Gly Ser
Glu Arg Gln Asn Gly Val Leu145 150 155 160Asn Ser Trp Thr Asp Gln
Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 165 170 175Ser Thr Leu Thr
Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 180 185 190Thr Cys
Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 195 200
205Phe Asn Arg Asn Glu Cys 210156450PRTArtificial SequenceSynthetic
156Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly
Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala
Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys
Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly
Thr Leu Val Thr Val Ser Ser Ala Ser 115 120 125Thr Thr Pro Pro Ser
Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln 130 135 140Thr Asn Ser
Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro145 150 155
160Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val
165 170 175His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu
Ser Ser 180 185 190Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu
Thr Val Thr Cys 195 200 205Asn Val Ala His Pro Ala Ser Ser Thr Lys
Val Asp Lys Lys Ile Val 210 215 220Pro Arg Asp Cys Gly Cys Lys Pro
Cys Ile Cys Thr Val Pro Glu Val225 230 235
240Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile
245 250 255Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Ala Ile Ser
Lys Asp 260 265 270Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp
Val Glu Val His 275 280 285Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln
Phe Ala Ser Thr Phe Arg 290 295 300Ser Val Ser Glu Leu Pro Ile Met
His Gln Asp Trp Leu Asn Gly Lys305 310 315 320Glu Phe Lys Cys Arg
Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu 325 330 335Lys Thr Ile
Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr 340 345 350Thr
Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu 355 360
365Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp
370 375 380Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln
Pro Ile385 390 395 400Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser
Lys Leu Asn Val Gln 405 410 415Lys Ser Asn Trp Glu Ala Gly Asn Thr
Phe Thr Cys Ser Val Leu His 420 425 430Glu Gly Leu His Asn His His
Thr Glu Lys Ser Leu Ser His Ser Pro 435 440 445Gly Lys
450157450PRTArtificial SequenceSynthetic 157Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile
Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75
80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser
Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser Ala Ser 115 120 125Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro
Gly Ser Ala Ala Gln 130 135 140Thr Asn Ser Met Val Thr Leu Gly Cys
Leu Val Lys Gly Tyr Phe Pro145 150 155 160Glu Pro Val Thr Val Thr
Trp Asn Ser Gly Ser Leu Ser Ser Gly Val 165 170 175His Thr Phe Pro
Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser 180 185 190Ser Val
Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys 195 200
205Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val
210 215 220Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro
Glu Val225 230 235 240Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys
Asp Val Leu Thr Ile 245 250 255Thr Leu Thr Pro Lys Val Thr Cys Val
Val Val Asp Ile Ser Lys Asp 260 265 270Asp Pro Glu Val Gln Phe Ser
Trp Phe Val Asp Asp Val Glu Val His 275 280 285Thr Ala Gln Thr Gln
Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 290 295 300Ser Val Ser
Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys305 310 315
320Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu
325 330 335Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln
Val Tyr 340 345 350Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp
Lys Val Ser Leu 355 360 365Thr Cys Met Ile Thr Asp Phe Phe Pro Glu
Asp Ile Thr Val Glu Trp 370 375 380Gln Trp Asn Gly Gln Pro Ala Glu
Asn Tyr Lys Asn Thr Gln Pro Ile385 390 395 400Met Asp Thr Asp Gly
Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln 405 410 415Lys Ser Asn
Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His 420 425 430Glu
Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro 435 440
445Gly Lys 450158456PRTArtificial SequenceSynthetic 158Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val
Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr
Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40
45Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala
Tyr65 70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val
Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly
Val Cys Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
Thr Val Ser Ser Ala Ser 115 120 125Thr Thr Ala Pro Ser Val Tyr Pro
Leu Ala Pro Val Cys Gly Asp Thr 130 135 140Thr Gly Ser Ser Val Thr
Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro145 150 155 160Glu Pro Val
Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val 165 170 175His
Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser 180 185
190Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys
195 200 205Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys
Ile Glu 210 215 220Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys
Lys Cys Pro Ala225 230 235 240Pro Asn Leu Leu Gly Gly Pro Ser Val
Phe Ile Phe Pro Pro Lys Ile 245 250 255Lys Asp Val Leu Met Ile Ser
Leu Ser Pro Ile Val Thr Cys Val Val 260 265 270Val Ala Val Ser Glu
Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 275 280 285Asn Asn Val
Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 290 295 300Tyr
Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln305 310
315 320Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys
Asp 325 330 335Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys
Gly Ser Val 340 345 350Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro
Glu Glu Glu Met Thr 355 360 365Lys Lys Gln Val Thr Leu Thr Cys Met
Val Thr Asp Phe Met Pro Glu 370 375 380Asp Ile Tyr Val Glu Trp Thr
Asn Asn Gly Lys Thr Glu Leu Asn Tyr385 390 395 400Lys Asn Thr Glu
Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 405 410 415Ser Lys
Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 420 425
430Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys
435 440 445Ser Phe Ser Arg Thr Pro Gly Lys 450
455159456PRTArtificial SequenceSynthetic 159Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile
Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75
80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser
Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser Ala Ser 115 120 125Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro
Val Cys Gly Asp Thr 130 135 140Thr Gly Ser Ser Val Thr Leu Gly Cys
Leu Val Lys Gly Tyr Phe Pro145 150 155 160Glu Pro Val Thr Leu Thr
Trp Asn Ser Gly Ser Leu Ser Ser Gly Val 165 170 175His Thr Phe Pro
Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser 180 185 190Ser Val
Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys 195 200
205Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu
210 215 220Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys
Pro Ala225 230 235 240Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile
Phe Pro Pro Lys Ile 245 250 255Lys Asp Val Leu Met Ile Ser Leu Ser
Pro Ile Val Thr Cys Val Val 260 265 270Val Asp Val Ser Glu Asp Asp
Pro Asp Val Gln Ile Ser Trp Phe Val 275 280 285Asn Asn Val Glu Val
His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 290 295 300Tyr Asn Ser
Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln305 310 315
320Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp
325 330 335Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly
Ser Val 340 345 350Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu
Glu Glu Met Thr 355 360 365Lys Lys Gln Val Thr Leu Thr Cys Met Val
Thr Asp Phe Met Pro Glu 370 375 380Asp Ile Tyr Val Glu Trp Thr Asn
Asn Gly Lys Thr Glu Leu Asn Tyr385 390 395 400Lys Asn Thr Glu Pro
Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 405 410 415Ser Lys Leu
Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 420 425 430Ser
Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys 435 440
445Ser Phe Ser Arg Thr Pro Gly Lys 450 455160237PRTArtificial
SequenceSynthetic 160Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 20 25 30Phe Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu 35 40 45Val Thr Cys Val Val Val Ala Val
Ser His Glu Asp Pro Glu Val Lys 50 55 60Phe Asn Trp Tyr Val Asp Gly
Val Glu Val His Asn Ala Lys Thr Lys65 70 75 80Pro Arg Glu Glu Gln
Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 85 90 95Thr Val Leu His
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 100 105 110Val Ser
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 115 120
125Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
130 135 140Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
Val Lys145 150 155 160Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
Glu Ser Asn Gly Gln 165 170 175Pro Glu Asn Asn Tyr Lys Thr Thr Pro
Pro Val Leu Asp Ser Asp Gly 180 185 190Ser Phe Phe Leu Tyr Ser Lys
Leu Thr Val Asp Lys Ser Arg Trp Gln 195 200 205Gln Gly Asn Val Phe
Ser Cys Ser Val Met His Glu Ala Leu His Asn 210 215 220His Tyr Thr
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225 230
235161233PRTArtificial SequenceSynthetic 161Val Asp Lys Thr Val Glu
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val
Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 20 25 30Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 35 40 45Val Val Ala
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 50 55 60Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu65 70 75
80Gln Phe Ala Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His
85 90 95Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys 100 105 110Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr
Lys Gly Gln 115 120 125Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
Ser Arg Glu Glu Met 130 135 140Thr Lys Asn Gln Val Ser Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro145 150 155 160Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 165 170 175Tyr Lys Thr Thr
Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 180 185 190Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 195 200
205Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
210 215 220Lys Ser Leu Ser Leu Ser Pro Gly Lys225
230162234PRTArtificial SequenceSynthetic 162Val Asp Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40 45Val Val Val
Ala Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 50 55 60Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu65 70 75
80Glu Gln Phe Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
85 90 95His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn 100 105 110Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Gln Glu Glu 130 135 140Met Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr145 150 155 160Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 195 200
205Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
210 215 220Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys225
23016367PRTArtificial SequenceSynthetic 163Val Asp Lys Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 20 25 30Phe Pro Pro Thr
Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu 35 40 45Val Lys Phe
Asn Trp Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 50 55 60Ala Pro
Ile6516466PRTArtificial SequenceSynthetic 164Val Asp Lys Lys Val
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro
Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 20 25 30Pro Pro Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 35 40 45Lys Phe
Asn Trp Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 50 55 60Pro
Ile6516566PRTArtificial SequenceSynthetic 165Val Asp Lys Lys Val
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro
Ala Pro Glu Leu Leu Gly Pro Ser Val Phe Leu Phe 20 25
30Pro Pro Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val
35 40 45Lys Phe Asn Trp Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
Ala 50 55 60Pro Ile6516666PRTArtificial SequenceSynthetic 166Val
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10
15Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe
20 25 30Pro Pro Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
Val 35 40 45Lys Phe Asn Trp Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
Pro Ser 50 55 60Ser Ile6516767PRTArtificial SequenceSynthetic
167Val Asp Lys Lys Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser1
5 10 15Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe
Leu 20 25 30Phe Pro Pro Thr Cys Val Val Val Asp Val Ser His Glu Asp
Pro Glu 35 40 45Val Lys Phe Asn Trp Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro 50 55 60Ala Pro Ile6516867PRTArtificial
SequenceSynthetic 168Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
Lys Thr His Thr Ser1 5 10 15Pro Pro Ser Pro Ala Pro Pro Val Ala Gly
Gly Pro Ser Val Phe Leu 20 25 30Phe Pro Pro Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu 35 40 45Val Lys Phe Asn Trp Tyr Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro 50 55 60Ala Pro
Ile6516963PRTArtificial SequenceSynthetic 169Val Asp Lys Thr Val
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro
Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Thr 20 25 30Cys Val Val
Val Ala Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 35 40 45Trp Tyr
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 50 55
6017063PRTArtificial SequenceSynthetic 170Val Asp Lys Thr Val Glu
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Ala
Ala Ala Ser Ser Val Phe Leu Phe Pro Pro Thr 20 25 30Cys Val Val Val
Asp Val Ser Ala Glu Asp Pro Glu Val Gln Phe Asn 35 40 45Trp Tyr Lys
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 50 55
6017163PRTArtificial SequenceSynthetic 171Val Asp Lys Thr Val Glu
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val
Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Thr 20 25 30Cys Val Val Val
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 35 40 45Trp Tyr Lys
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 50 55
6017263PRTArtificial SequenceSynthetic 172Val Asp Lys Thr Val Glu
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Ala
Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Thr 20 25 30Cys Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 35 40 45Trp Tyr Lys
Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 50 55
6017362PRTHomo sapiens 173Val Asp Lys Thr Val Glu Arg Lys Cys Cys
Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val Ala Pro Ser Val
Phe Leu Phe Pro Pro Thr Cys 20 25 30Val Val Val Ala Val Ser His Glu
Asp Pro Glu Val Gln Phe Asn Trp 35 40 45Tyr Lys Cys Lys Val Ser Asn
Lys Gly Leu Pro Ala Pro Ile 50 55 6017464PRTArtificial
SequenceSynthetic 174Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser
Val Phe Leu Phe Pro Pro 20 25 30Thr Cys Val Val Val Ala Val Ser Gln
Glu Asp Pro Glu Val Gln Phe 35 40 45Asn Trp Tyr Lys Cys Lys Val Ser
Asn Lys Gly Leu Pro Ser Ser Ile 50 55 6017564PRTArtificial
SequenceSynthetic 175Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val Ala Gly Gly Pro Ser
Val Phe Leu Phe Pro Pro 20 25 30Thr Cys Val Val Val Ala Val Ser Gln
Glu Asp Pro Glu Val Gln Phe 35 40 45Asn Trp Tyr Lys Cys Lys Val Ser
Asn Lys Gly Leu Pro Ser Ser Ile 50 55 6017664PRTArtificial
SequenceSynthetic 176Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Ala Leu Gly Ala Pro Ser
Val Phe Leu Phe Pro Pro 20 25 30Thr Cys Val Val Val Asp Val Ser Gln
Glu Asp Pro Glu Val Gln Phe 35 40 45Asn Trp Tyr Lys Cys Lys Val Ser
Asn Lys Gly Leu Pro Ser Ser Ile 50 55 6017764PRTArtificial
SequenceSynthetic 177Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser
Val Phe Leu Phe Pro Pro 20 25 30Thr Cys Val Val Val Asp Val Ser Gln
Glu Asp Pro Glu Val Gln Phe 35 40 45Asn Trp Tyr Lys Cys Lys Val Ser
Asn Lys Gly Leu Pro Ser Ser Ile 50 55 60178236PRTArtificial
SequenceSynthetic 178Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala Pro Pro Val Ala Gly
Pro Ser Val Phe Leu Phe 20 25 30Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val 35 40 45Thr Cys Val Val Val Asp Val Ser
His Glu Asp Pro Glu Val Lys Phe 50 55 60Asn Trp Tyr Val Asp Gly Val
Glu Val His Asn Ala Lys Thr Lys Pro65 70 75 80Arg Glu Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 85 90 95Val Leu His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 100 105 110Ser Asn
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 115 120
125Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
130 135 140Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly145 150 155 160Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro 165 170 175Glu Asn Asn Tyr Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser 180 185 190Phe Phe Leu Tyr Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln 195 200 205Gly Asn Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His 210 215 220Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys225 230 235179236PRTArtificial
SequenceSynthetic 179Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Pro Ser Val Phe Leu Phe 20 25 30Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val 35 40 45Thr Cys Val Val Val Ala Val Ser
His Glu Asp Pro Glu Val Lys Phe 50 55 60Asn Trp Tyr Val Asp Gly Val
Glu Val His Asn Ala Lys Thr Lys Pro65 70 75 80Arg Glu Glu Gln Tyr
Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr 85 90 95Val Leu His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 100 105 110Ser Asn
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 115 120
125Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
130 135 140Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly145 150 155 160Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro 165 170 175Glu Asn Asn Tyr Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser 180 185 190Phe Phe Leu Tyr Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln 195 200 205Gly Asn Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His 210 215 220Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys225 230 235180237PRTArtificial
SequenceSynthetic 180Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 20 25 30Phe Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu 35 40 45Val Thr Cys Val Val Val Asp Val
Ser His Glu Asp Pro Glu Val Lys 50 55 60Phe Asn Trp Tyr Val Asp Gly
Val Glu Val His Asn Ala Lys Thr Lys65 70 75 80Pro Arg Glu Glu Gln
Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 85 90 95Thr Val Leu His
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 100 105 110Val Ser
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 115 120
125Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
130 135 140Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
Val Lys145 150 155 160Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
Glu Ser Asn Gly Gln 165 170 175Pro Glu Asn Asn Tyr Lys Thr Thr Pro
Pro Val Leu Asp Ser Asp Gly 180 185 190Ser Phe Phe Leu Tyr Ser Lys
Leu Thr Val Asp Lys Ser Arg Trp Gln 195 200 205Gln Gly Asn Val Phe
Ser Cys Ser Val Met His Glu Ala Leu His Asn 210 215 220His Tyr Thr
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225 230
235181236PRTArtificial SequenceSynthetic 181Val Asp Lys Lys Val Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala
Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 20 25 30Pro Pro Lys Pro
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 35 40 45Thr Cys Val
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 50 55 60Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro65 70 75
80Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
85 90 95Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val 100 105 110Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
Ser Lys Ala 115 120 125Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg 130 135 140Glu Glu Met Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys Gly145 150 155 160Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 165 170 175Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 180 185 190Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 195 200
205Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
210 215 220Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225 230
235182237PRTArtificial SequenceSynthetic 182Val Asp Lys Lys Val Glu
Pro Lys Ser Ser Asp Lys Thr His Thr Ser1 5 10 15Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 20 25 30Phe Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 35 40 45Val Thr Cys
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 50 55 60Phe Asn
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys65 70 75
80Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
85 90 95Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys 100 105 110Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys 115 120 125Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser 130 135 140Arg Glu Glu Met Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu Val Lys145 150 155 160Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 165 170 175Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 180 185 190Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 195 200
205Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
210 215 220His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225
230 235183237PRTArtificial SequenceSynthetic 183Val Asp Lys Lys Val
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser1 5 10 15Pro Pro Ser Pro
Ala Pro Pro Val Ala Gly Gly Pro Ser Val Phe Leu 20 25 30Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 35 40 45Val Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 50 55 60Phe
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys65 70 75
80Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
85 90 95Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys 100 105 110Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys 115 120 125Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser 130 135 140Arg Glu Glu Met Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu Val Lys145 150 155 160Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 165 170 175Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 180 185 190Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 195 200
205Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
210 215 220His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys225
230 235184237PRTArtificial SequenceSynthetic 184Val Asp Lys Lys Val
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro
Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 20 25 30Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 35 40 45Val Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 50 55 60Phe
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys65 70 75
80Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
85 90 95Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys 100 105 110Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr
Ile Ser Lys 115 120 125Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser 130 135 140Arg Glu Glu Met Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu Val Lys145 150 155 160Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 165 170 175Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly 180 185 190Ser Phe Phe Leu Tyr Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln 195 200 205Gln Gly Asn Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn 210 215 220His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys225 230 235185233PRTArtificial
SequenceSynthetic 185Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val
Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Ala Ala Ala Ser Ser Val
Phe Leu Phe Pro Pro Lys 20 25 30Pro Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val 35 40 45Val Val Asp Val Ser Ala Glu Asp
Pro Glu Val Gln Phe Asn Trp Tyr 50 55 60Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg Glu Glu65 70 75 80Gln Phe Asn Ser Thr
Phe Arg Val Val Ser Val Leu Thr Val Leu His 85 90 95Gln Asp Trp Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 100 105 110Gly Leu
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 115 120
125Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
130 135 140Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro145 150 155 160Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn 165 170 175Tyr Lys Thr Thr Pro Pro Met Leu Asp
Ser Asp Gly Ser Phe Phe Leu 180 185 190Tyr Ser Lys Leu Thr Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val 195 200 205Phe Ser Cys Ser Val
Met His Glu Ala Leu His Asn His Tyr Thr Gln 210 215 220Lys Ser Leu
Ser Leu Ser Pro Gly Lys225 230186233PRTArtificial SequenceSynthetic
186Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1
5 10 15Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys 20 25 30Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val 35 40 45Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe
Asn Trp Tyr 50 55 60Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu Glu65 70 75 80Gln Phe Asn Ser Thr Phe Arg Val Val Ser
Val Leu Thr Val Leu His 85 90 95Gln Asp Trp Leu Asn Gly Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys 100 105 110Gly Leu Pro Ser Ser Ile Glu
Lys Thr Ile Ser Lys Thr Lys Gly Gln 115 120 125Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 130 135 140Thr Lys Asn
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro145 150 155
160Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
165 170 175Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe
Phe Leu 180 185 190Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln Gly Asn Val 195 200 205Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr Thr Gln 210 215 220Lys Ser Leu Ser Leu Ser Pro Gly
Lys225 230187232PRTArtificial SequenceSynthetic 187Val Asp Lys Thr
Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro
Pro Val Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45Val
Ala Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 50 55
60Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln65
70 75 80Phe Ala Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His
Gln 85 90 95Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys Gly 100 105 110Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr
Lys Gly Gln Pro 115 120 125Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
Ser Arg Glu Glu Met Thr 130 135 140Lys Asn Gln Val Ser Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser145 150 155 160Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175Lys Thr Thr
Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200
205Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220Ser Leu Ser Leu Ser Pro Gly Lys225
230188233PRTArtificial SequenceSynthetic 188Val Asp Lys Thr Val Glu
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val
Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 20 25 30Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 35 40 45Val Val Asp
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 50 55 60Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu65 70 75
80Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
85 90 95Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys 100 105 110Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala
Lys Gly Gln 115 120 125Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
Ser Gln Glu Glu Met 130 135 140Thr Lys Asn Gln Val Ser Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro145 150 155 160Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 165 170 175Tyr Lys Thr Thr
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 180 185 190Tyr Ser
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 195 200
205Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
210 215 220Lys Ser Leu Ser Leu Ser Leu Gly Lys225
230189234PRTArtificial SequenceSynthetic 189Val Asp Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40 45Val Val Val
Ala Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 50 55 60Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu65 70 75
80Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Val
85 90 95His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn 100 105 110Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Gln Glu Glu 130 135 140Met Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr145 150 155 160Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 195 200
205Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
210 215 220Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys225
230190234PRTArtificial SequenceSynthetic 190Val Asp Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Pro Val
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40 45Val Val Val
Ala Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 50 55 60Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu65 70 75
80Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
85 90 95His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn 100 105 110Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Gln Glu Glu 130 135 140Met Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr145 150 155 160Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 195 200
205Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
210 215 220Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys225
230191234PRTArtificial SequenceSynthetic 191Val Asp Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Ala
Leu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40 45Val Val Val
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 50 55 60Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu65 70 75
80Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
85 90 95His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Lys Cys Lys Val Ser
Asn 100 105 110Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Gln Glu Glu 130 135 140Met Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr145 150 155 160Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 195 200
205Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
210 215 220Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys225
230192234PRTArtificial SequenceSynthetic 192Val Asp Lys Arg Val Glu
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys1 5 10 15Pro Ala Pro Glu Ala
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 20 25 30Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 35 40 45Val Val Val
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 50 55 60Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu65 70 75
80Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
85 90 95His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn 100 105 110Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 115 120 125Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Gln Glu Glu 130 135 140Met Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr145 150 155 160Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 165 170 175Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 180 185 190Leu Tyr
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 195 200
205Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
210 215 220Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys225
230193456PRTArtificial SequenceSynthetic 193Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile
Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75
80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser
Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro Val Thr Val Ser
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200
205Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
210 215 220Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
Pro Ala225 230 235 240Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro 245 250 255Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val 260 265 270Val Ala Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val 275 280 285Asp Gly Val Glu Val
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 290 295 300Tyr Ala Ser
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln305 310 315
320Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
325 330 335Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro 340 345 350Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Glu Glu Met Thr 355 360 365Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser 370 375 380Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr385 390 395 400Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 405 410 415Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 420 425 430Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 435 440
445Ser Leu Ser Leu Ser Pro Gly Lys 450 455194455PRTArtificial
SequenceSynthetic 194Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly
Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly
Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr
Arg
Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg Leu
Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro
Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp Tyr
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120 125Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 130 135
140Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
Pro145 150 155 160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
Thr Ser Gly Val 165 170 175His Thr Phe Pro Ala Val Leu Gln Ser Ser
Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser Ser
Ser Leu Gly Thr Gln Thr Tyr Ile 195 200 205Cys Asn Val Asn His Lys
Pro Ser Asn Thr Lys Val Asp Lys Lys Val 210 215 220Glu Pro Lys Ser
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala225 230 235 240Pro
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 245 250
255Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
260 265 270Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
Val Asp 275 280 285Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
Glu Glu Gln Tyr 290 295 300Asn Ser Thr Tyr Arg Val Val Ser Val Leu
Thr Val Leu His Gln Asp305 310 315 320Trp Leu Asn Gly Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys Ala Leu 325 330 335Pro Ala Pro Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 340 345 350Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 355 360 365Asn
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 370 375
380Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
Lys385 390 395 400Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
Phe Leu Tyr Ser 405 410 415Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln Gly Asn Val Phe Ser 420 425 430Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr Thr Gln Lys Ser 435 440 445Leu Ser Leu Ser Pro Gly
Lys 450 455195455PRTArtificial SequenceSynthetic 195Gln Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly
Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55
60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65
70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys
Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
Ser Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala
Pro Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly Thr Ala Ala Leu Gly
Cys Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro Val Thr Val
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175His Thr Phe
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200
205Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
210 215 220Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
Pro Ala225 230 235 240Pro Glu Leu Leu Gly Pro Ser Val Phe Leu Phe
Pro Pro Lys Pro Lys 245 250 255Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val Val 260 265 270Ala Val Ser His Glu Asp Pro
Glu Val Lys Phe Asn Trp Tyr Val Asp 275 280 285Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 290 295 300Ala Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp305 310 315
320Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
325 330 335Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg 340 345 350Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
Glu Met Thr Lys 355 360 365Asn Gln Val Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp 370 375 380Ile Ala Val Glu Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys385 390 395 400Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 405 410 415Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 420 425 430Cys
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 435 440
445Leu Ser Leu Ser Pro Gly Lys 450 455196456PRTArtificial
SequenceSynthetic 196Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly
Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly
Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr
Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg
Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln
Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120
125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
130 135 140Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro145 150 155 160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200 205Cys Asn Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 210 215 220Glu Pro Lys
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala225 230 235
240Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
245 250 255Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
Val Val 260 265 270Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr Val 275 280 285Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg Glu Glu Gln 290 295 300Tyr Ala Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val Leu His Gln305 310 315 320Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 325 330 335Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 340 345 350Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 355 360
365Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
370 375 380Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
Asn Tyr385 390 395 400Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
Ser Phe Phe Leu Tyr 405 410 415Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln Gln Gly Asn Val Phe 420 425 430Ser Cys Ser Val Met His Glu
Ala Leu His Asn His Tyr Thr Gln Lys 435 440 445Ser Leu Ser Leu Ser
Pro Gly Lys 450 455197455PRTArtificial SequenceSynthetic 197Gln Val
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25
30Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys
Phe 50 55 60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr
Ala Tyr65 70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala
Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn
Gly Val Cys Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu
Val Thr Val Ser Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe
Pro Leu Ala Pro Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly Thr Ala
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170
175His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
180 185 190Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
Tyr Ile 195 200 205Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val
Asp Lys Lys Val 210 215 220Glu Pro Lys Ser Cys Asp Lys Thr His Thr
Cys Pro Pro Cys Pro Ala225 230 235 240Pro Pro Val Ala Gly Pro Ser
Val Phe Leu Phe Pro Pro Lys Pro Lys 245 250 255Asp Thr Leu Met Ile
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 260 265 270Asp Val Ser
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 275 280 285Gly
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 290 295
300Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
Asp305 310 315 320Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys Gly Leu 325 330 335Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln Pro Arg 340 345 350Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Glu Glu Met Thr Lys 355 360 365Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 370 375 380Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys385 390 395 400Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 405 410
415Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
420 425 430Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
Lys Ser 435 440 445Leu Ser Leu Ser Pro Gly Lys 450
455198456PRTArtificial SequenceSynthetic 198Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile
Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75
80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser
Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro Val Thr Val Ser
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200
205Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
210 215 220Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser
Pro Ala225 230 235 240Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu
Phe Pro Pro Lys Pro 245 250 255Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val 260 265 270Val Asp Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val 275 280 285Asp Gly Val Glu Val
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 290 295 300Tyr Asn Ser
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln305 310 315
320Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
325 330 335Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro 340 345 350Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Glu Glu Met Thr 355 360 365Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser 370 375 380Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr385 390 395 400Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 405 410 415Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 420 425 430Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 435 440
445Ser Leu Ser Leu Ser Pro Gly Lys 450 455199456PRTArtificial
SequenceSynthetic 199Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly
Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly
Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr
Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg
Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln
Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120
125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
130 135 140Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro145 150 155 160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200 205Cys Asn Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 210 215 220Glu Pro Lys
Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala225 230 235
240Pro Pro
Val Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 245 250
255Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
260 265 270Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
Tyr Val 275 280 285Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
Arg Glu Glu Gln 290 295 300Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
Leu Thr Val Leu His Gln305 310 315 320Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val Ser Asn Lys Ala 325 330 335Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 340 345 350Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 355 360 365Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 370 375
380Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
Tyr385 390 395 400Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu Tyr 405 410 415Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val Phe 420 425 430Ser Cys Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr Gln Lys 435 440 445Ser Leu Ser Leu Ser Pro
Gly Lys 450 455200452PRTArtificial SequenceSynthetic 200Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val
Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr
Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40
45Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
50 55 60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala
Tyr65 70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val
Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly
Val Cys Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
Thr Val Ser Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe Pro
Leu Ala Pro Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly Thr Ala Ala
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro Val
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185
190Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
195 200 205Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
Thr Val 210 215 220Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro
Ala Pro Pro Val225 230 235 240Ala Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro Lys Asp Thr Leu 245 250 255Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val Ala Val Ser 260 265 270His Glu Asp Pro Glu
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285Val His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr 290 295 300Phe
Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn305 310
315 320Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala
Pro 325 330 335Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg
Glu Pro Gln 340 345 350Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
Thr Lys Asn Gln Val 355 360 365Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val 370 375 380Glu Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro385 390 395 400Pro Met Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425
430Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
435 440 445Ser Pro Gly Lys 450201452PRTArtificial SequenceSynthetic
201Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly
Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala
Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys
Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly
Thr Leu Val Thr Val Ser Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro145 150 155
160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
165 170 175His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
Gln Thr Tyr Ile 195 200 205Cys Asn Val Asn His Lys Pro Ser Asn Thr
Lys Val Asp Lys Thr Val 210 215 220Glu Arg Lys Cys Cys Val Glu Cys
Pro Pro Cys Pro Ala Pro Pro Ala225 230 235 240Ala Ala Ser Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255Met Ile Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270Ala
Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280
285Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr
290 295 300Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
Leu Asn305 310 315 320Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Gly Leu Pro Ser Ser 325 330 335Ile Glu Lys Thr Ile Ser Lys Thr Lys
Gly Gln Pro Arg Glu Pro Gln 340 345 350Val Tyr Thr Leu Pro Pro Ser
Arg Glu Glu Met Thr Lys Asn Gln Val 355 360 365Ser Leu Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro385 390 395
400Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
405 410 415Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
Ser Val 420 425 430Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu 435 440 445Ser Pro Gly Lys 450202452PRTArtificial
SequenceSynthetic 202Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly
Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly
Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr
Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg
Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln
Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120
125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
130 135 140Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro145 150 155 160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200 205Cys Asn Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val 210 215 220Glu Arg Lys
Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val225 230 235
240Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
245 250 255Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
Val Ser 260 265 270Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
Asp Gly Val Glu 275 280 285Val His Asn Ala Lys Thr Lys Pro Arg Glu
Glu Gln Phe Asn Ser Thr 290 295 300Phe Arg Val Val Ser Val Leu Thr
Val Leu His Gln Asp Trp Leu Asn305 310 315 320Gly Lys Glu Tyr Lys
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 325 330 335Ile Glu Lys
Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350Val
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 355 360
365Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
370 375 380Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
Thr Pro385 390 395 400Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
Tyr Ser Lys Leu Thr 405 410 415Val Asp Lys Ser Arg Trp Gln Gln Gly
Asn Val Phe Ser Cys Ser Val 420 425 430Met His Glu Ala Leu His Asn
His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445Ser Pro Gly Lys
450203452PRTArtificial SequenceSynthetic 203Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile
Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75
80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser
Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro Val Thr Val Ser
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200
205Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val
210 215 220Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
Pro Ala225 230 235 240Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys
Pro Lys Asp Thr Leu 245 250 255Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val Val Val Asp Val Ser 260 265 270His Glu Asp Pro Glu Val Gln
Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 290 295 300Phe Arg Val
Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn305 310 315
320Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro
325 330 335Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
Pro Gln 340 345 350Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
Lys Asn Gln Val 355 360 365Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile Ala Val 370 375 380Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr Thr Pro385 390 395 400Pro Met Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415Val Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430Met
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440
445Ser Pro Gly Lys 450204451PRTArtificial SequenceSynthetic 204Gln
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10
15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
20 25 30Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln
Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser
Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr
Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr
Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr
Leu Val Thr Val Ser Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly Thr
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170
175His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
180 185 190Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
Tyr Ile 195 200 205Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val
Asp Lys Thr Val 210 215 220Glu Arg Lys Cys Cys Val Glu Cys Pro Pro
Cys Pro Ala Pro Pro Val225 230 235 240Ala Pro Ser Val Phe Leu Phe
Pro Pro Lys Pro Lys Asp Thr Leu Met 245 250 255Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val Val Ala Val Ser His 260 265 270Glu Asp Pro
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 275 280 285His
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Phe 290 295
300Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn
Gly305 310 315 320Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
Pro Ala Pro Ile 325 330 335Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln
Pro Arg Glu Pro Gln Val 340 345 350Tyr Thr Leu Pro Pro Ser Arg Glu
Glu Met Thr Lys Asn Gln Val Ser 355 360 365Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 370 375 380Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro385 390 395 400Met
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 405 410
415Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
420 425
430His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
435 440 445Pro Gly Lys 450205452PRTArtificial SequenceSynthetic
205Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly
Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala
Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys
Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly
Thr Leu Val Thr Val Ser Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro145 150 155
160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
165 170 175His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
Gln Thr Tyr Ile 195 200 205Cys Asn Val Asn His Lys Pro Ser Asn Thr
Lys Val Asp Lys Thr Val 210 215 220Glu Arg Lys Cys Cys Val Glu Cys
Pro Pro Cys Pro Ala Pro Pro Val225 230 235 240Ala Gly Pro Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255Met Ile Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270Gln
Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280
285Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr
290 295 300Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
Leu Asn305 310 315 320Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Gly Leu Pro Ser Ser 325 330 335Ile Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro Gln 340 345 350Val Tyr Thr Leu Pro Pro Ser
Gln Glu Glu Met Thr Lys Asn Gln Val 355 360 365Ser Leu Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro385 390 395
400Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr
405 410 415Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys
Ser Val 420 425 430Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu 435 440 445Ser Leu Gly Lys 450206453PRTArtificial
SequenceSynthetic 206Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly
Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly
Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr
Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg
Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln
Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120
125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
130 135 140Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro145 150 155 160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200 205Cys Asn Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 210 215 220Glu Ser Lys
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe225 230 235
240Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
245 250 255Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
Ala Val 260 265 270Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
Val Asp Gly Val 275 280 285Glu Val His Asn Ala Lys Thr Lys Pro Arg
Glu Glu Gln Phe Ala Ser 290 295 300Thr Tyr Arg Val Val Ser Val Leu
Thr Val Leu His Gln Asp Trp Leu305 310 315 320Asn Gly Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 325 330 335Ser Ile Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 340 345 350Gln
Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 355 360
365Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
370 375 380Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
Thr Thr385 390 395 400Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
Leu Tyr Ser Arg Leu 405 410 415Thr Val Asp Lys Ser Arg Trp Gln Glu
Gly Asn Val Phe Ser Cys Ser 420 425 430Val Met His Glu Ala Leu His
Asn His Tyr Thr Gln Lys Ser Leu Ser 435 440 445Leu Ser Leu Gly Lys
450207456PRTArtificial SequenceSynthetic 207Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile
Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75
80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser
Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro Val Thr Val Ser
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200
205Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
210 215 220Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
Pro Ala225 230 235 240Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro 245 250 255Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val 260 265 270Val Asp Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val 275 280 285Asp Gly Val Glu Val
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 290 295 300Tyr Asn Ser
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln305 310 315
320Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
325 330 335Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro 340 345 350Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Glu Glu Met Thr 355 360 365Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser 370 375 380Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr385 390 395 400Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 405 410 415Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 420 425 430Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 435 440
445Ser Leu Ser Leu Ser Pro Gly Lys 450 455208452PRTArtificial
SequenceSynthetic 208Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly
Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly
Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr
Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg
Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln
Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120
125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr
130 135 140Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro145 150 155 160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser
Ser Asn Phe Gly Thr Gln Thr Tyr Thr 195 200 205Cys Asn Val Asp His
Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val 210 215 220Glu Arg Lys
Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val225 230 235
240Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
245 250 255Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
Val Ser 260 265 270His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
Asp Gly Val Glu 275 280 285Val His Asn Ala Lys Thr Lys Pro Arg Glu
Glu Gln Phe Asn Ser Thr 290 295 300Phe Arg Val Val Ser Val Leu Thr
Val Val His Gln Asp Trp Leu Asn305 310 315 320Gly Lys Glu Tyr Lys
Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 325 330 335Ile Glu Lys
Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350Val
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 355 360
365Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
370 375 380Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
Thr Pro385 390 395 400Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
Tyr Ser Lys Leu Thr 405 410 415Val Asp Lys Ser Arg Trp Gln Gln Gly
Asn Val Phe Ser Cys Ser Val 420 425 430Met His Glu Ala Leu His Asn
His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445Ser Pro Gly Lys
450209453PRTArtificial SequenceSynthetic 209Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile
Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75
80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser
Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Cys Ser Arg Ser Thr 130 135 140Ser Glu Ser Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro Val Thr Val Ser
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 195 200
205Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val
210 215 220Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro
Glu Phe225 230 235 240Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr 245 250 255Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp Val 260 265 270Ser Gln Glu Asp Pro Glu Val
Gln Phe Asn Trp Tyr Val Asp Gly Val 275 280 285Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 290 295 300Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu305 310 315
320Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
325 330 335Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
Glu Pro 340 345 350Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
Thr Lys Asn Gln 355 360 365Val Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala 370 375 380Val Glu Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr385 390 395 400Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 405 410 415Thr Val Asp
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 420 425 430Val
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 435 440
445Leu Ser Leu Gly Lys 450210456PRTArtificial SequenceSynthetic
210Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1
5 10 15Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly
Tyr 20 25 30Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 35 40 45Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala
Gln Lys Phe 50 55 60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
Ser Thr Ala Tyr65 70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys
Thr Asn Gly Val Cys Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly
Thr Leu Val Thr Val Ser Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro145 150 155
160Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200 205Cys Asn Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 210 215 220Glu Pro Lys
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala225 230 235
240Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
245 250 255Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
Val Val 260 265 270Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr Val 275 280 285Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg Glu Glu Gln 290 295 300Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val Leu His Gln305 310 315 320Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 325 330 335Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 340 345 350Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 355 360
365Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
370 375 380Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
Asn Tyr385 390 395 400Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
Ser Phe Phe Leu Tyr 405 410 415Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln Gln Gly Asn Val Phe 420 425 430Ser Cys Ser Val Met His Glu
Ala Leu His Asn His Tyr Thr Gln Lys 435 440 445Ser Leu Ser Leu Ser
Pro Gly Lys 450 455211456PRTArtificial SequenceSynthetic 211Gln Val
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25
30Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys
Phe 50 55 60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr
Ala Tyr65 70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala
Val Tyr Tyr Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn
Gly Val Cys Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu
Val Thr Val Ser Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe
Pro Leu Ala Pro Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly Thr Ala
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170
175His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
180 185 190Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
Tyr Ile 195 200 205Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val
Asp Lys Lys Val 210 215 220Glu Pro Lys Ser Cys Asp Lys Thr His Thr
Cys Pro Pro Cys Pro Ala225 230 235 240Pro Glu Ala Ala Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro 245 250 255Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 260 265 270Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 275 280 285Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 290 295
300Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
Gln305 310 315 320Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
Ser Asn Lys Ala 325 330 335Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser
Lys Ala Lys Gly Gln Pro 340 345 350Arg Glu Pro Gln Val Tyr Thr Leu
Pro Pro Ser Arg Glu Glu Met Thr 355 360 365Lys Asn Gln Val Ser Leu
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 370 375 380Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr385 390 395 400Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 405 410
415Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
420 425 430Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
Gln Lys 435 440 445Ser Leu Ser Leu Ser Pro Gly Lys 450
455212453PRTArtificial SequenceSynthetic 212Gln Val Gln Leu Val Gln
Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met His Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly Trp Ile
Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65 70 75
80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser
Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Cys Ser Arg Ser Thr 130 135 140Ser Glu Ser Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro Val Thr Val Ser
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175His Thr Phe Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser Val
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 195 200
205Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val
210 215 220Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro
Glu Phe225 230 235 240Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr 245 250 255Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp Val 260 265 270Ser Gln Glu Asp Pro Glu Val
Gln Phe Asn Trp Tyr Val Asp Gly Val 275 280 285Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 290 295 300Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu305 310 315
320Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
325 330 335Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
Glu Pro 340 345 350Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
Thr Lys Asn Gln 355 360 365Val Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala 370 375 380Val Glu Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr385 390 395 400Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 405 410 415Thr Val Asp
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 420 425 430Val
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 435 440
445Leu Ser Leu Gly Lys 450213233PRTArtificial SequenceSynthetic
213Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys1
5 10 15Pro Ala Pro Pro Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro
Lys 20 25 30Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val 35 40 45Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe
Asn Trp Tyr 50 55 60Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu Glu65 70 75 80Gln Phe Asn Ser Thr Phe Arg Val Val Ser
Val Leu Thr Val Val His 85 90 95Gln Asp Trp Leu Asn Gly Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys 100 105 110Gly Leu Pro Ala Pro Ile Glu
Lys Thr Ile Ser Lys Thr Lys Gly Gln 115 120 125Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 130 135 140Thr Lys Asn
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro145 150 155
160Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
165 170 175Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe
Phe Leu 180 185 190Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln Gly Asn Val 195 200 205Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr Thr Gln 210 215 220Lys Ser Leu Ser Leu Ser Pro Gly
Lys225 230214456PRTArtificial SequenceSynthetic 214Gln Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala1 5 10 15Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30Tyr Met
His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45Gly
Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55
60Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr65
70 75 80Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
Cys 85 90 95Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys
Ser Tyr 100 105 110Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
Ser Ser Ala Ser 115 120 125Thr Lys Gly Pro Ser Val Phe Pro Leu Ala
Pro Ser Ser Lys Ser Thr 130 135 140Ser Gly Gly Thr Ala Ala Leu Gly
Cys Leu Val Lys Asp Tyr Phe Pro145 150 155 160Glu Pro Val Thr Val
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175His Thr Phe
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200
205Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
210 215 220Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
Pro Ala225 230 235 240Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro 245 250 255Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val 260 265 270Val Asp Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val 275 280 285Asp Gly Val Glu Val
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 290 295 300Tyr Asn Ser
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln305 310 315
320Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
325 330 335Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro 340 345 350Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Glu Glu Met Thr 355 360 365Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser 370 375 380Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr385 390 395 400Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 405 410 415Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 420 425 430Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 435 440
445Ser Leu Ser Leu Ser Pro Gly Lys 450 45521567PRTArtificial
SequenceSynthetic 215Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
Lys Thr His Thr Cys1 5 10 15Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly
Gly Pro Ser Val Phe Leu 20 25 30Phe Pro Pro Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu 35 40 45Val Lys Phe Asn Trp Tyr Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro 50 55 60Ala Ser Ile65
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