U.S. patent application number 16/894723 was filed with the patent office on 2021-12-09 for antibacterial pro-coagulant formula.
The applicant listed for this patent is Richard Steven Trela. Invention is credited to Richard Steven Trela.
Application Number | 20210379045 16/894723 |
Document ID | / |
Family ID | 1000005100849 |
Filed Date | 2021-12-09 |
United States Patent
Application |
20210379045 |
Kind Code |
A1 |
Trela; Richard Steven |
December 9, 2021 |
ANTIBACTERIAL PRO-COAGULANT FORMULA
Abstract
The disclosed invention provides an antibacterial pro-coagulant
formula for assisting in combating the condition of bleeding gums
caused by periodontal disease and gingivitis that enhances the
natural healing process by assisting in the of cessation of
bleeding by providing an "anti-bacterial oral healing environment"
accompanied by enhanced blood flow to the affected bleeding area
for more rapid blood clotting and increased blood flow to the
affected area to assist the body's natural process of rebuilding
healthy gum-tissue. Additionally, the disclosed invention with its
antibacterial benefits, when used topically, provides for rapid
surface skin blood clotting as well as increased blood circulation
on the skin surface which greatly aids in the healing of external
skin cuts, such as nicks from shaving or against inflammation of
the skin from acne vulgaris. Continued use of the product orally
and topically has proven to provide a beneficial stability to
overall oral and skin health, especially useful in promoting
healing in high-bacterial environments, such as is common in a
person's mouth or on their face. Further described is a method of
promoting hair follicle growth by application of the presented
invention to a human scalp to promote blood flow to the scalp
through below skin surface blood vessel dilation and below surface
anti-bacterial cleansing of the scalp effecting an unrestricted and
healthy skin tissue environment conducive to promoting hair
follicle re-growth.
Inventors: |
Trela; Richard Steven;
(US) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
Trela; Richard Steven |
|
|
US |
|
|
Family ID: |
1000005100849 |
Appl. No.: |
16/894723 |
Filed: |
June 5, 2020 |
Current U.S.
Class: |
1/1 |
Current CPC
Class: |
A61K 9/08 20130101; A61K
2800/70 20130101; A61K 9/0058 20130101; A61K 33/40 20130101; A61K
8/4926 20130101; A61K 2800/87 20130101; A61K 2800/92 20130101; A61K
9/0014 20130101; A61K 9/06 20130101; A61K 9/7015 20130101; A61K
8/22 20130101; A61Q 7/00 20130101; A61K 31/455 20130101; A61P 31/04
20180101; A61Q 11/00 20130101 |
International
Class: |
A61K 31/455 20060101
A61K031/455; A61K 33/40 20060101 A61K033/40; A61P 31/04 20060101
A61P031/04; A61K 9/68 20060101 A61K009/68; A61K 9/70 20060101
A61K009/70; A61K 9/06 20060101 A61K009/06; A61K 9/08 20060101
A61K009/08; A61K 9/00 20060101 A61K009/00; A61Q 7/00 20060101
A61Q007/00; A61K 8/49 20060101 A61K008/49; A61K 8/22 20060101
A61K008/22; A61Q 11/00 20060101 A61Q011/00 |
Claims
1. An antibacterial pro-coagulant comprising: (a)
Pyridine-3-Carboxylic Acid (Niacin) (B-3) and (b) Dihydrogen
Dioxide (Hydrogen Peroxide)
2. The antibacterial pro-coagulant of claim 1 wherein the
Pyridine-3-Carboxylic Acid (Niacin) is present in a concentration
of 0.01 wt % to 3.0 wt %, based on the total weight of the
antibacterial pro-coagulant.
3. The antibacterial pro-coagulant of claim 1 wherein the
Dihydrogen Dioxide (Hydrogen Peroxide) is present in a
concentration of 97.00 wt % to 99.99 wt %, based on the total
weight of the antibacterial pro-coagulant.
4. The antibacterial pro-coagulant of claim 1, wherein the
concentration ratio of the Pyridine-3-Carboxylic Acid (Niacin) to
the Dihydrogen Dioxide (Hydrogen Peroxide) in the antibacterial
pro-coagulant composition is from 1:1000 to 1:1.
5. The antibacterial pro-coagulant of any preceding claim 1,
further comprising Dihydrogen Oxide (Distilled Water), or
optionally (potable, high PH or purified water).
6. The antibacterial pro-coagulant of claim 5, wherein the
Dihydrogen Oxide (Distilled Water) or optionally (potable, high PH
or purified water is present in the antibacterial pro-coagulant
composition in a concentration of 0.1 wt % to 75 wt %, based on the
total weight of the antibacterial pro-coagulant.
7. The antibacterial pro-coagulant of any preceding claim 1,
further comprising either calcium carbonate or calcium citrate.
8. The antibacterial pro-coagulant of claim 7, wherein the calcium
carbonate or calcium citrate is present in the antibacterial
pro-coagulant composition in a concentration of 0.001 wt % to 3 wt
%, based on the total weight of the antibacterial
pro-coagulant.
9. The antibacterial pro-coagulant of any preceding claim 1,
further comprising Vitamin D-3.
10. The antibacterial pro-coagulant of claim 9, wherein the Vitamin
D-3. is present in the antibacterial pro-coagulant composition in a
concentration of 0.001 wt % to 3 wt %, based on the total weight of
the antibacterial pro-coagulant.
11. The antibacterial pro-coagulant of any preceding claim 1,
further comprising a food grade acidic agent, such as, distilled
white vinegar or apple cider vinegar, with an acidity level of
4-6%.
12. The antibacterial pro-coagulant of claim 11, wherein the food
grade acidic agent, such as, distilled white vinegar or apple cider
vinegar, with an acidity level of 4-6%. is present in the
antibacterial pro-coagulant composition in a concentration of 0.01
wt % to 15 wt %, based on the total weight of the antibacterial
pro-coagulant.
13. In accordance with claim 1, the anti-bacterial pro-coagulant
suspended in an excipient medium in the form of a liquid, paste,
gel, spray, gum, bandage or application stick.
14. In accordance with claim 1, the antibacterial pro-coagulant
further comprising: (a) Pyridine-3-Carboxylic Acid (Niacin) (B-3),
(b) Dihydrogen Dioxide (Hydrogen Peroxide), (c) Dihydrogen Oxide
(distilled water) or optionally (Potable, high PH or purified
water) and (d) optionally, orally-acceptable excipients.
15. In accordance with claim 1, an oral antibacterial pro-coagulant
composition based on its weight comprising from (a) about 0.01% to
about 5% weight of Niacin (B-3) and (b) based on its weight, 99.99%
to about 95% of 3% by volume of hydrogen peroxide in purified
water.
16. In accordance with claim 1, an oral antibacterial pro-coagulant
composition in a 32 fluid ounce by volume container further
comprising: (a) between 50 milligrams and 5,000 milligrams of
Niacin (B-3) dissolved into about (b) 16 fluid ounces of 3% by
volume hydrogen peroxide in purified water, and (c) further
dissolved into about 16 fluid ounces of (c) Dihydrogen Oxide
(distilled water) or optionally potable, high PH or purified water
for a total 32 fluid oz. volume comprised of (a), (b) and (c) or
(d) in a 32 fluid ounce volume container.
17. In accordance with claim 1, an oral antibacterial pro-coagulant
composition in a 32 fluid ounce by volume container further
comprising: (a) between 50 milligrams and 5,000 milligrams of
Niacin (B-3) dissolved in about (b) 16 fluid ounces, of 3% by
volume of hydrogen peroxide in purified water, and (c) further
dissolved into about 12 fluid ounces of (c) Dihydrogen Oxide
(distilled water) or optionally high PH or purified water, (d)
optionally, orally acceptable excipients (e) 1000 mg. of calcium
carbonate, and (f) 175 IU of Vitamin D-3 further dissolved into (g)
about 4 fluid ounces of a food grade acidic agent, such as,
distilled white vinegar or apple cider vinegar, with an acidity
level of 4-6% in a 32 fluid ounce volume container.
18. In accordance with claim 1, an oral antibacterial pro-coagulant
composition in a 32 fluid ounce by volume container further
comprising: (a) between 50 milligrams and 5,000 milligrams of
Niacin (B-3) dissolved in (b) between 16 fluid ounces and 24 fluid
ounces of 3% by volume of hydrogen peroxide in purified water, and
(c) further dissolved into between 8 fluid ounces and 12 fluid
ounces of distilled or purified water, (d) optionally, orally
acceptable excipients (e) 1000 mg. of calcium carbonate, and (f)
175 IU of Vitamin D-3 further dissolved into (g) 4 fluid ounces of
a food grade acidic agent, such as, distilled white vinegar or
apple cider vinegar with an acidity level of 4-6% combined with (b)
and (c) for a composition in a 32 fluid ounce by volume
container.
19. In accordance with claims 1-14, an oral antibacterial
pro-coagulant composition in the embodiment of an oral rinse that
is capable or being used as an oral rinse or administered via a
power water jet flossing machine and that is administered as a
replacement of, or additive to, water or other oral health
liquids.
20. In accordance with claims 1-14 a method for the treatment of
gum disease and the prevention of gingivitis comprising
administering the antibacterial pro-coagulant to the gums of person
in need thereof, preferably twice or more a day.
21. In accordance with claim 1, 2, 3, 4, 5, and 6, a method of
treating inflamed skin, insect bite inflammation, surface skin cuts
and acne conditions by applying the topical paste applied to the
face or body topically for the facilitation of healing of facial
inflammation due to bacteria-causing skin breakouts and acne.
22. In accordance with claims 1, 2, 3, 4, 5 and 6 an oral
antibacterial pro-coagulant composition in the embodiment of an
oral rinse, oral gel, toothpaste, gum or spray
23. In accordance with claims 1, 2 and 9 a topical pro-coagulant
paste composition further comprising: (a) between 550 milligrams
and 5,000 milligrams of Niacin (B-3) dissolved in (b) between 1
fluid ounce and 2 fluid ounces of 3% by volume of hydrogen peroxide
in purified water, and (c) further mixed into between 1 tablespoon
and 2 tablespoons of Xanthan gum or other optional thickening agent
to form a stable topical paste for application to surface skin cuts
to stop bleeding and assist in the healing of inflamed skin due to
acne.
24. A method of treating or preventing a disease or condition of
the oral cavity, comprising applying an oral care composition
according to claims 1-5 to the oral cavity.
25. A method of protecting gums from gingivitis or periodontal
disease, the method comprising applying an oral care composition
according to claim 1-5 to the gum surface.
26. A method of claim 14 comprising the steps of: (a) adding the
composition in accordance with claims 1-14 to a water jet flossing
machine tank, (b) turning on the water jet and concentrating the
water pulse irrigation on problem gum areas first. (c) next, using
the water jet to irrigate along the entire gum-line of both upper
and lower gums, both inside and out (d) allow bacterial foaming to
dissipate and expectorate the foam as it forms in the mouth, (e)
rinse with distilled, purified or clean water.
27. In accordance with earlier referenced claims 1-26, a method of
promoting hair follicle growth by application of the presented
invention to a human scalp to promote blood flow to the scalp
through below skin surface blood vessel dilation and below surface
anti-bacterial cleansing of the scalp effecting an unrestricted and
healthy skin tissue environment conducive to promoting hair
follicle growth.
Description
STATEMENT OF FEDERALLY SPONSORED RESEARCH
[0001] N/A
FIELD OF INVENTION
[0002] The presented invention relates to oral care and more
specifically to an antibacterial pro-coagulant composition for gum
care and for use in the treatment of gingivitis, bleeding gums, gum
inflammation and periodontal disease. Additionally, the invented
formula provides a breakthrough in the field of topical treatments
for acne, skin rejuvenation, insect bite relief and first aid for
stopping bleeding from razor nicks. Further described is a method
of promoting hair follicle growth by application of the presented
invention to a human scalp to promote blood flow to the scalp
through below skin surface blood vessel dilation and below surface
anti-bacterial cleansing of the scalp effecting an unrestricted and
healthy skin tissue environment conducive to promoting hair
follicle re-growth.
BACKGROUND OF THE INVENTION
[0003] Dental plaque is a sticky biofilm or a mass of bacteria that
is commonly found between the teeth, along the gumline, and below
the gumline margins. Dental plaque can give rise to dental caries
and periodontal problems, such as gingivitis and periodontitis. In
the early stages, periodontitis has very few symptoms, and in many
individuals the disease has progressed significantly before they
seek treatment. Symptoms may include redness or bleeding of gums
while brushing teeth, using dental floss or biting into hard food.
Other symptoms include gum-swelling that recurs, spitting out blood
after brushing teeth, halitosis, or bad breath, and a persistent
metallic taste in the mouth. Deep-pockets between the teeth and the
gums, and loose teeth occur in the later stages.
[0004] Deep teeth-cleaning, also referred to as root planing or
scaling, is a procedure carried out by a dental hygienist to treat
periodontal and gum disease. The scaling process scrapes away
bacterial plaque and tartar from the tooth. Sometimes, deep
teeth-cleaning results in or furthers inflammation of the gums. In
a regular cleaning, scaling is performed on the part of the tooth
that is exposed above the gumline.
[0005] A deep-cleaning is a periodontal procedure used to treat
early-stage periodontal (gum) disease. A dentist, periodontist (gum
specialist), or dental hygienist removes the plaque through a
deep-cleaning method that combines scaling and root planing.
Scaling is performed above and below the gumline to remove plaque
and tartar. Root planing gets rid of rough spots on the tooth where
germs gather, and helps remove bacteria that contribute to gum
disease.
[0006] Although deep-cleaning is effective at removing plaque
buildup, it does not eliminate all the bacteria that cause gum
disease. Currently, when necessary, treatment may also include
placing medication such as Arestin or Perio-Chip into gum pockets
if the pocket is greater than 4 mm. In that case, patients are
advised to postpone brushing for 12 hours and avoid the use of
inter-proximal cleaning devices (flossing) for 10 days.
[0007] It is this recovery period of time after periodontal
treatment in which, due to the inflammation and open wounds caused
by the deep-cleaning procedure itself, that a "bacteria free"
healing environment is needed for natural gum healing. All too
often, the patient fails to achieve lasting results due to the fact
that there has not been, until now, a workable system to provide a
"bacteria-free enough" and healthy enough oral environment, long
enough, to allow the gums a chance to heal naturally.
[0008] It would be similar to having an open wound on the body. If
it were open and bleeding, and it was not allowed to go through the
natural healing stages of the cessation of bleeding, followed by
the healing of the inflammation and then onto its healthy tissue
re-growth stage, (due to the open wound being in a wet environment
under constant bacterial attack, like the environment gums are
exposed to after periodontal treatment), of course the healing
process itself, would, at best, be a source of further health and
healing complications due to infection, protracted exposure to the
bacterial environment, as well as being painful to the patient.
[0009] The presented invention with its active indigents combined
and administered as described herein, has exceptional
anti-bacterial, anti-inflammatory, and deep-cleansing benefits on
patients who recently had their teeth professionally deep-cleaned
by a dentist or hygienist. The presented invention provides a
breakthrough anti-bacterial and pro-coagulant "oral healing
environment" that is greatly efficacious in the restoration of gums
from a periodontal "emergency state" of bleeding gums, to a
reinstated natural healthy condition that provides the desired
"fresh start", so many of today's periodontists, dentists and
hygienists are desiring for their trusting oral care patients.
4 Main Gum Healing Phases:
[0010] Gum healing can be divided into 4 overlapping phases:
Hemostasis, Inflammatory, Proliferative and Maturity
Phase 1: Hemostasis Phase
[0011] Hemostasis, the first phase of healing, could be said to
begin at the onset of injury, and the objective is to stop the
bleeding. In this phase, the body activates its emergency repair
system, namely the blood clotting system, and forms a dam to block
the drainage. During this process, platelets come into contact with
collagen, resulting in activation and aggregation. An enzyme called
thrombin is at the center, and it initiates the formation of a
fibrin mesh, which strengthens the platelet clumps into a stable
clot.
Phase 2: Defensive/Inflammatory Phase
[0012] Phase 1 is primarily about coagulation, the second phase,
could be called the Defensive/Inflammatory Phase and it focuses on
destroying bacteria and removing debris-essentially preparing the
wound bed for the growth of new tissue.
[0013] During Phase 2, a type of white blood cells called
neutrophils enter the wound to destroy bacteria and remove debris.
These cells often reach their peak population between 24 and 48
hours after injury, reducing greatly in number after three days. As
the white blood cells leave, specialized cells called macrophages
arrive to continue clearing debris. These cells also secrete growth
factors and proteins that attract immune system cells to the wound
to facilitate tissue repair. This phase often lasts four to six
days and is often associated with edema, erythema (reddening of the
skin), heat and pain.
Phase 3: Proliferative Phase
[0014] Once the wound is cleaned out, the wound could b e said to
enter Phase 3, the Proliferative Phase, where the focus is to fill
and cover the wound.
[0015] The Proliferative phase features three distinct stages: 1)
filling the wound; 2) contraction of the wound margins; and 3)
covering the wound (epithelialization).
[0016] During the first stage, shiny, deep red granulation tissue
fills the wound bed with connective tissue, and new blood vessels
are formed. During contraction, the wound margins contract and pull
toward the center of the wound. In the third stage, epithelial
cells arise from the wound bed or margins and begin to migrate
across the wound bed in leapfrog fashion until the wound is covered
with epithelium.
Phase 4: Maturation Phase
[0017] During the Maturation phase, the new tissue slowly gains
strength and flexibility. Here, collagen fibers reorganize, the
tissue remodels and matures and there is an overall increase in
tensile strength (though maximum strength is limited to 80% of the
pre-injured strength). The Maturation phase varies greatly from
wound to wound, often lasting anywhere from 21 days to two
years.
[0018] The healing process is remarkable and complex, but it is
also susceptible to interruption due to local and systemic factors,
including moisture, bacterial infection, and maceration.
[0019] The presented invention when used as described herein
provides a greatly improved antibacterial and pro-coagulant healing
environment due to increased blood circulation and improved
clotting to more a rapidly assist the body through the 4 main
healing phases to heal and replace devitalized gum and skin
tissue.
BRIEF SUMMARY
[0020] Disclosed herein is an anti-bacterial and pro-coagulant
composition that includes (a) (NIACIN) Pyridine-3-Carboxylic Acid,
(b) (HYDROGEN PEROXIDE) and optionally (c) Dihydrogen Dioxide,
(DISTILLED WATER) Dihydrogen Oxide, potable water or purified
water, (d) (CALCIUM) Calcium 7440-70-2 and optionally (e) (VITAMIN
D3) Cholecalciferol. In some embodiments, the oral and topical care
antibacterial pro-coagulant composition can be in the form of a
liquid, paste, gel, spray, gum or other excipient.
[0021] Further areas of applicability of the present disclosure
will become apparent from the detailed description provided
hereinafter. It should be understood that the detailed description
and specific examples, while indicating the preferred embodiment of
the disclosure, are intended for purposes of illustration only and
are not intended to limit the scope of the disclosure.
SUMMARY
[0022] Hydrogen Peroxide kills bacteria by oxidizing their cell
walls, stealing electrons from them and disrupting their chemical
structures. Niacin is required for the proper function of fats and
sugars in the body and to maintain healthy cells. Niacin also
causes the small blood vessels on the skin and in the gums to
dilate so more blood can rush to an area affected by skin
inflammation, gingivitis or periodontal inflammation or injury due
to dental deep-cleaning tools and procedures. At higher doses,
niacin has beneficial effects on speed of blood clotting. It has
now been discovered that niacin, when dissolved and placed in
formulation with hydrogen peroxide, and when used as described
herein, is effective in fighting gum-disease, aids in stopping
gum-bleeding and gum-inflammation, and can simultaneously provide
an effective concentration of Niacin to promote enhanced blood
circulation and clotting to the injured or inflamed gum tissue, as
well as provide an enhanced anti-bacterial and increased blood flow
environment for gum tissue rehabilitation. Optionally used along
with the basic inventive combination of Niacin and Hydrogen
Peroxide, as an additional benefit, distilled water can be added
which is effective in removing toxins in the body and is soluble
and combines well with Niacin and Hydrogen Peroxide. Additionally,
Calcium which is beneficial in bone growth and strength, and
vitamin D3 which assists in the body's absorption of Calcium can
also be added as described herein to provide vital building blocks
for bone-strengthening and natural tissue and bone re-growth.
EXAMPLES OF DENTAL PATIENT USE OF THE PRESENTED INVENTION DURING
PERIODONTAL DISEASE RECOVERY STAGES
Phase 1: Hemostasis Phase
[0023] When brushing or flossing, if bleeding gums occur, use the
current invention as follows: add 2/3 parts of current invention
and 1/3 part distilled water to your water jet flossing machine
tank. Set pulse as high as comfortable and concentrate pulse
irrigation on problem gum areas first. Lean over sink and spend the
1st % of the tank drain time on known deep pocket gum areas,
working to get a deep rinse on each pocket. Next, power rinse along
the entire gum-line of both upper and lower gums, both inside and
out. When the tank is empty, continue to lean over the sink and
allow the presented invention formula to foam out bacteria and
particles freely from your mouth. This may foam for some time, so
be patient until foaming ceases. When foaming has subsided, brush
teeth and rinse thoroughly after brushing. Repeat daily, in the
morning and again at night, until the bleeding phase is
cleared.
2: Defensive/Inflammatory Phase
[0024] Once the bleeding phase has passed, the presented invention
greatly assists in destroying harmful bacteria and removing deep
food debris helping clear the way for inflamed gums to grow healthy
and strong. In Phase 2, add a 1/2 ratio part of the presented
invention formula and 1/2 part distilled to your water jet flossing
machine tank. Repeat procedure as in Phase 1.
Phase 3: Proliferative Phase
[0025] The presented invention assists in the re-growth of healthy
gums by providing a healthy oral environment which continues to
defend against harmful bacteria growth and assists the body it's
natural recovery process. In Phase 3, use 1/3 the presented
invention and 2/3.sup.rds distilled water in the water jet flossing
machine tank and follow the same procedure as Phase 1, and 2 for
use.
Phase 4: Maturation Phase
[0026] During the Maturation phase, the new tissue slowly gains
strength and flexibility. The presented invention assists in the
re-growth of healthy gums by providing a healthy oral environment
by continuing to defend against harmful bacteria growth and assists
the body's natural recovery process. In Phase 4, use a ratio of 1/4
of the presented invention to 3/4 distilled water in the water jet
flossing machine tank and follow the same procedure as Phase 1, 2,
and 3 for use.
DRAWING FIGURES
[0027] FIG. 1--shows a human tooth with gums that have receded away
from the tooth due to bacterial decay. 1.1 shows a gap between the
tooth and 1.2 shows bacteria in the gums.
[0028] FIG. 2 shows the presented invention filling the gaps with
the Niacin and Peroxide formula. 2.1 shows the formula attacking
the bacteria, 2.2 and 2.3 shows the formula filling the gap and
soaking the bacteria laden gun area.
[0029] FIG. 3--Shows the now recovered gum structure with the gums
grown back to healthy state. FIG. 3.1 shows the now healthy gums
and 3.2 shows the gums now tight against the tooth.
[0030] FIG- 4 is an illustration that shows the 4 stages of wound
healing. 4.1 is the Hemostasis stage. 4.2 is the Inflammatory
stage. 4.3 is the Proliferative stage and 4.4 is the Remodeling
stage.
* * * * *