U.S. patent application number 17/178692 was filed with the patent office on 2021-11-11 for botanical film-forming acne compositions.
The applicant listed for this patent is The Trustees of Columbia University in the City of New York. Invention is credited to Chathuranga C. De Silva, Shanta M. Modak.
Application Number | 20210346425 17/178692 |
Document ID | / |
Family ID | 1000005728515 |
Filed Date | 2021-11-11 |
United States Patent
Application |
20210346425 |
Kind Code |
A1 |
Modak; Shanta M. ; et
al. |
November 11, 2021 |
BOTANICAL FILM-FORMING ACNE COMPOSITIONS
Abstract
The present technology relates to botanical film-forming
compositions useful for the treatment of acne related skin
disorders, as well as methods of treating such disorders. The
compositions herein are advantageous in that they treat acne
related skin disorders quickly and with minimal irritation and side
effects.
Inventors: |
Modak; Shanta M.; (River
Edge, NJ) ; De Silva; Chathuranga C.; (Cliffside
Park, NJ) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
The Trustees of Columbia University in the City of New
York |
New York |
NY |
US |
|
|
Family ID: |
1000005728515 |
Appl. No.: |
17/178692 |
Filed: |
February 18, 2021 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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16415339 |
May 17, 2019 |
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17178692 |
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62684030 |
Jun 12, 2018 |
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Current U.S.
Class: |
1/1 |
Current CPC
Class: |
A61K 9/0014 20130101;
A61K 9/06 20130101; A61K 36/28 20130101; A61K 36/886 20130101; A61P
17/10 20180101; A61K 31/327 20130101; A61K 9/107 20130101; A61K
47/38 20130101; A61K 33/30 20130101; A61K 31/192 20130101 |
International
Class: |
A61K 33/30 20060101
A61K033/30; A61K 47/38 20060101 A61K047/38; A61K 31/327 20060101
A61K031/327; A61K 31/192 20060101 A61K031/192; A61P 17/10 20060101
A61P017/10; A61K 36/886 20060101 A61K036/886; A61K 9/00 20060101
A61K009/00; A61K 9/107 20060101 A61K009/107; A61K 9/06 20060101
A61K009/06; A61K 36/28 20060101 A61K036/28 |
Claims
1. A method of treating an acne related skin disorder, the method
comprising contacting with the skin an acne treatment composition
that achieves more than 3 log.sub.10 reduction of bacterial growth
from control group within 15 second contact with acne causing
bacteria, wherein the acne treatment composition comprises; a. a
combination of 0.05 to 0.2% w/w rosemary oil, 0.3 to 1% w/w
pomegranate extract, 0.2 to 2% w/w licorice extract, and 0.1 to
0.5% w/w orange oil; b. 0.5 to 2% w/w salicylic acid and 0.1 and 1%
w/w glycolic acid; c. 0.5 to 10% w/w of one or more emollient
solvent selected from 1,3 propanediol, ethylhexylglycerin, butylene
glycol, or any combination thereof; d. 0.1 to 3% w/w one or more
polymer selected from hydroxypropyl cellulose, hydroxypropylmethyl
cellulose, or any combination thereof; and e. 0.1 to 1% w/w one or
more zinc salt selected from zinc gluconate, zinc lactate, or any
combination thereof.
2. The method of claim 1, wherein the acne treatment composition
further comprises Green tea extract, Calendula extract, Witch hazel
extract, Aloe extract, Grapefruit seed extract, Basil oil, Jojoba
oil, Tea tree oil, Vetiver oil, Red Sandalwood extract,
Resveratrol, Vitamin E, Vitamin C or any combination thereof.
3. The method of claim 2, wherein the acne treatment composition
further comprises one or more emulsifiers or one or more
solubilizers.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a Divisional Application of U.S. patent
application Ser. No. 16/415,339, filed on May 17, 2019, entitled
"Botanical Film-Forming Acne Compositions", which claims the
benefit of U.S. Provisional Patent Application No. 62/684,030 filed
Jun. 12, 2018, the contents of which are incorporated by reference
in their entirety.
BACKGROUND
[0002] The present technology relates to compositions suitable for
treating acne related skin disorders.
[0003] Acne, also known as acne vulgaris, is a chronic inflammatory
disease of the skin, found in 80% of adolescents and young adults.
It is a skin condition characterized by primary lesions on the
face, chest, and back, which form when the skin pores become
clogged with oil, dead skin cells, and bacteria. Acne often occurs
when the sebaceous glands overproduce sebum. A clogged pore can
also accumulate dirt, debris, and bacteria. When the blockage or
plug (comedone) ruptures, the material inside can spread to
surrounding skin. The resulting skin condition with sebum
enrichment is prone to the anaerobic growth of Propionibacterium
acnes, which is the main causative microorganism in acne. In
addition, Staphylococcus epidermidis and Staphylococcus aureus can
be present in acne lesions. Proliferation of these microorganisms,
mainly P. acnes, leads to inflammatory lesions and severe acne.
[0004] Current methods that are used to reduce sebum production,
unclog pores, or treat acne include caustic agents that can further
lead to skin irritation or can result in dry and flaky skin. Acne
also causes significant psychological morbidity in affected
patients.
[0005] Some treatments have been introduced to decrease the
aesthetic and psychological problems caused by acne. Products
currently available for the treatment of acne include systemic and
topical treatments. The topical application of therapeutic agents
has been found to be more feasible than hormonal treatment and
laser therapy. Active agents currently used for topical therapy are
retinoic acid and derivatives, benzoyl peroxide salicylic acid, and
antibiotics. While it has been noted that salicylic acid is the
least deleterious agent among all other topical agents, continued
use of these agents can cause adverse effects, e.g. skin
irritation, redness and bacterial resistance. Furthermore, certain
formulations can take a significant amount of time, up to 6 weeks,
to improve skin. Herbs and naturally derived compounds in topical
acne treatments have received interest as they seem to have fewer
adverse effects than synthetic agents. However, these agents tend
to be slow in acting, and therefore high concentrations are needed
for efficacy; this can be toxic.
[0006] Previously, we have developed anti acne formulations
containing salicylic acid based on our patented technology (U.S.
Pat. Nos. 7,563,461 and 7,879,365) to treat acne related skin
disorders. This 4 step treatment involves the use of a cleanser, a
toner, a lotion and a spot cream to be applied twice daily. This
treatment has shown significant, visible improvement in acne
affected skin during regular use of 4-6 weeks.
[0007] However, research has shown that, like most competing
anti-acne topical products currently available, the 4 step
treatment can be time consuming, and therefore patients may not
adhere to this routine.
[0008] Thus, there is an ongoing need for new and innovative
therapies that are fast acting, come from natural sources, are
simple to use and cause minimal irritation.
SUMMARY
[0009] In certain embodiments, the present technology is directed
to a composition suitable for treating an acne related skin
disorder, comprising:
[0010] (a) 0.1 to 1% w/w hydroxypropyl methylcellulose stearoxy
ether (hydrophobically modified hydroxypropyl methylcellulose)
(HPMCSE polymer);
[0011] (b) 0.1 to 1% w/w soluble zinc salt, wherein the soluble
zinc salt is zinc gluconate, zinc lactate, zinc acetate, zinc
citrate or any combination thereof;
[0012] (c) an emulsifying agent, wherein the emulsifying agent
comprises: (1) 0.1 to 5% w/w of one more of: behentrimonium
methosulfate, cetyl alcohol, stearyl alcohol, butylene glycol, or a
cetyl alcohol and butylene glycol blend (referred to as BTMSCB) or
any combination thereof; and (2) 0.1 to 5% w/w nonionic
self-emulsifying wax (e.g., Polawax.TM.); and
[0013] (d) 0.5 to 2% w/w salicylic acid, or 0.5 to 10% w/w benzoyl
peroxide, or a combination thereof.
[0014] In other embodiments, the compositions herein further
comprise chitosan, e.g., 0.1 to 1%; and cellulose polymer, e.g.
hydroxyethyl cellulose, hydroxyl propyl methyl cellulose, methyl
cellulose, polyquaternium 10, or any combination thereof; in
amounts of, e.g., 0.1 to 3%.
[0015] In other embodiments, the compositions herein further
comprise calendula oil or extract, in amounts of, e.g., 0.1 to 20%
or 0.1 to 2%; or aloe gel or extract, in amounts of, e.g., 0.1 to
5%, 0.1 to 50%, or any combination thereof.
[0016] In other embodiments, the compositions herein further
include emollient solvent, wherein the emollient solvent is
1,3-propanediol (for example, that available under the trade name
Zemea.RTM. from DuPont Tate & Lyle Bio Products Company, LLC of
Loudon, Tenn., USA), glycerin, caprylil capryl triglyceride,
butylene glycol, octanediol, decanediol, benzyl alcohol, ethyl
hexyl glycerin, farnesol or any combination thereof, in amounts,
of, e.g., 0.5 to 10% w/w.
[0017] In other embodiments, the compositions herein further
comprise a botanical; in various embodiments, the botanical can be,
for example, orange oil, 0.05 to 0.2% w/w rosemary oil, 0.01 to
0.1% w/w vetiver oil, 0.01 to 0.1% w/w red sandalwood powder or
extract, 0.2 to 1% w/w pomegranate oil or extract, 0.3 to 1% w/w
grapefruit seed extract, 0.3 to 1% w/w lemon extract, 0.2 to 3% w/w
tea tree oil, 0.2 to 2% w/w arnica oil, 0.2 to 2% w/w licorice
extract, 0.2 to 2% w/w frankincense oil, 0.01 to 2% w/w helichrysum
oil, 0.01 to 2% w/w geranium oil, 0.01 to 2% w/w myrrh oil, 0.01 to
2% w/w neroli oil, 0.01 to 1% w/w Withania somnifera flower
extract, 0.01 to 1% w/w manjistha (Rubia cordifolia) extract, 0.5
to 5% onion extract, or any combination thereof.
[0018] In various embodiments, the compositions herein comprise
glycolic acid, lactic acid, benzoic acid or a combination thereof,
in amounts of 0.1 to 1% each--that is, for a total possible amount
of 3% of such acids.
[0019] In other embodiments, the compositions herein further
comprise an additional ingredient, including but not limited to: a
solvent or solubilizing agent; a surfactant water, alcohol,
sorbitan mono laurate (e.g., Tween.RTM. 20), sorbitan mono oleate
(e.g., Tween.RTM. 80), sorbitan oleate decylglucoside, sorbitan
sugar (e.g., Poly Suga.RTM. mulse), caprylil capryl glucoside, PEG
40 hydrogenated castor oil, trideceth-9 propylene glycol (e.g.,
Symrise.RTM. solubilizer 660352), cocoamidopropyl betaine, water or
any combination thereof.
[0020] In other embodiments, the compositions herein further
comprise an essential oil or constituent (ingredient) thereof, or a
botanical extract, including but not limited to: lavender oil,
chamomile oil, basil oil, thyme oil, thymol, menthol, orange oil,
vetiver oil, bakuchiol, jojoba oil, coconut oil, sun flower oil,
safflower oil, almond oil, bee honey, white tea extract, green tea
extract, resveratrol or any combination thereof.
[0021] In other embodiments, the compositions herein further
comprise a preservative, in amounts of, e.g., 0.1 to 1%. In various
embodiments, the preservative is chlorhexidine (for example,
chlorhexidine gluconate), benzalkonium chloride, phenoxyethanol,
phenyl ethanol or any combination thereof.
[0022] In other embodiments, the compositions herein further
comprise an antioxidant, e.g., Vitamin E, Vitamin C or any
combination thereof.
[0023] In other embodiments, the present technology is directed to
methods of treating an acne related skin disorder, comprising
contacting any of the compositions described herein with the
skin.
[0024] In other embodiments, the present technology is directed to
a method of treating an acne related skin disorder, comprising the
following steps:
[0025] (a) dissolving soluble zinc salt, aloe powder, lactic acid
and glycolic acid in water at a temperature of 50 to 60.degree.
C.;
[0026] (b) optionally adding a thickener or surfactant;
[0027] (c) adding an emulsifying agent, the emulsifying agent
comprising behentrimonium methosulfate, cetyl alcohol and butylene
glycol (BTMSCB) and nonionic self-emulsifying wax; and mixing until
dissolved;
[0028] (d) allowing the mixture to cool down to 30 to 40.degree.
C.;
[0029] (e) adding HPMCSE polymer gel, chitosan gel and calendula
extract;
[0030] (f) mixing to obtain a creamy gel (Phase A);
[0031] (g) combining salicylic acid and one or more botanical
extracts or oils in a solvent, and mixing (Phase B);
[0032] (h) combining Phase A and B to obtain an acne composition;
and
[0033] (i) contacting the acne composition with skin.
BRIEF DESCRIPTION OF THE DRAWINGS
[0034] FIG. 1 shows stability of formulations prepared herein (EC,
SC, SE-1, SE2, SCE-1 and SCE-2) at 7 days at 40.degree. C.
DETAILED DESCRIPTION
[0035] All percentages expressed herein are by weight unless
otherwise indicated.
[0036] In certain embodiments, the technology herein is directed to
a 2 step treatment for treating skin disorders related to acne
using a film forming gel containing salicylic acid and
botanicals.
[0037] As used herein, the terms "acne related skin disorders" and
"skin disorders related to acne" and interchangeable and mean any
skin condition caused by a buildup of dead skin cells, bacteria or
dried sebum that blocks the hair follicles in the skin, or causes
blackheads (open comedones), whiteheads (closed comedones), pimples
(papules), cysts or absesses in the skin.
[0038] As used herein, "essential oil" (EO) is a volatile oil
obtained from a plant or an animal source that comprises one or
more active agent (also referred to herein as an Isolated Component
or "IC" or "constituent" or "ingredient") which can be, for example
but not by way of limitation, a monoterpene or sesquiterpene
hydrocarbon, alcohol, ester, ether, aldehyde, ketone, or oxide.
Essential oils are commonly extracted by distillation, expression,
extraction, resin tapping, wax embedding or cold pressing. Isolated
components generally fall into the following categories: acids,
alcohols (e.g., monoterpenols or sesquiterpenols), aldehydes,
coumarins, esters, ketones, lactones, terpenes (e.g., monoterpenes
or sesquiterpenes), oxides, or phenols.
[0039] Throughout this present disclosure, when referring to a
natural (plant or animal) source of oil, for example, "lemon oil"
or "emu oil," this means the same thing as referring to the
essential oil; with the exception that where essential oil is not
commercially available, absolute oil is used.
[0040] As used herein, "botanical extract" means a composition from
a plant source (a botanical) that is prepared by soaking the
botanical in a solvent (e.g. water or alcohol). A botanical extract
refers to the resultant liquid, which contains the essential oil
with the solvent. As described in Examples and data herein, the
terminology "(100%/oil)" denotes 100% extract or oil.
[0041] Botanicals and naturally derived compounds in topical acne
treatments, have received considerable interest as they have fewer
adverse effects than synthetic agents. However, these agents are
slow acting and therefore high concentrations are needed to be
efficacious which can be toxic. Our earlier studies with botanicals
indicate that a combination treatment with botanicals and synthetic
agents can be more effective than the application of a single
product to inactivate bacteria.
[0042] We describe the development of a unique film forming gel
containing zinc, salicylic acid and botanicals (FGZB) formulation
to treat mild and moderate acne.
[0043] In certain embodiments, FGZB includes ingredients having
varied and therapeutic properties in combination. The unique
compositions described herein can inhibit the growth of microbes
that cause numerous conditions including acne, itching, erythema,
and scaling. The compositions can also result in reduction in the
numbers of papules and pustules; and can also be effective in
controlling sebum secretion. Additionally, in certain embodiments
the compositions herein can remain on the skin for longer period
and release the actives continuously into the skin upon
application.
[0044] In certain embodiments, the antibacterial actives in the
formulations are combinations of one or more botanicals and
salicylic acid. This unique technology, among other
characteristics, can: (i) enhance the antimicrobial efficacy of
salicylic acid; (ii) moisturize the skin rather than drying and
irritating it while staying non-greasy, and (iii) create a long
lasting barrier film on the skin preventing the passage of
irritants and bacteria, and at the same time inactivating skin
bacteria that cause acne lesions.
[0045] In certain embodiments, a composition herein comprises one
or more of the following ingredients (each described in turn):
[0046] (a) 0.1 to 1% w/w hydroxypropyl methylcellulose stearoxy
ether. This is a hydrophobically modified hydroxypropyl
methylcellulose polymer (HPMCSE polymer) that can form a unique
film forming hydrophobic/hydrophilic gel in water, and can provide
a silky smooth feel on the skin upon application.
[0047] (b) 0.1 to 1% soluble zinc salts. Exemplary zinc salts
include zinc gluconate, zinc lactate, zinc acetate, zinc citrate
and combinations thereof. Zinc salts are anti-irritant and
anti-inflammatory, and when combined with the film forming HPMCSE
polymer forms barrier matrix containing zinc which can precipitate
the proteins in the inflammatory papules and pustules and therefore
can reduce their size and appearance. Furthermore, this matrix can
prevent the passage of irritants and bacteria and at the same time
inactivating skin bacteria causing acne lesions.
[0048] (c) 0.1 to 5% emulsifying agents. Such emulsifying agents
can comprise any of the following: 1) BTMSCB which is a blend of
Behentrimonium Methosulfate (and) Cetyl Alcohol (and) Butylene
Glycol, an elegant vegetable based conditioning emulsifier; or 2)
0.1 to 3% of a nonionic self-emulsifying wax, e.g., those available
under the trade name Polawax.TM. and available from Croda Inc.
(Snaith, East Yorkshire, United Kingdom). Other emulsifiers include
those available under the trade name Ritabate.RTM. from Rita
Corporation (Crystal Lake, Ill., USA), and polyquaternium
emulsifiers available under the trade name Ucare.RTM. from Univar
Solutions (Downers Grove, Ill., USA). In certain embodiments, the
composition comprises a total of 0.2 to 10% w/w emulsifying agents,
for example, 0.1 to 5% of the options for 1) listed above, and 0.1
to 5% of the nonionic self-emulsifying wax of 2) listed above.
[0049] In certain embodiments, it has been found that combined use
of a, b, c ingredients in the formulation results in a stable film
forming gel (FGZ) which is non-sticky, non-greasy, with emollient
and moisturizing properties. When active ingredients e.g. salicylic
acid and botanicals are incorporated in FGZ, and applied on the
skin, they are released in a sustained manner for a prolonged
period inhibiting bacterial growth and reducing acne related skin
disorders.
[0050] (d) 0.2 to 2% of an alpha hydroxy acid e.g. salicylic acid,
lactic acid, glycolic acid or any combination thereof, which can
help to regenerate, or peel off, the top layer of skin, remove dead
skin cells and unclogging pores in the process, thus preventing
lesions and allowing for new clear skin to form.
[0051] In certain embodiments, the FGZ containing salicylic acid
can further comprise any of the following (1)-(9):
[0052] (1) 0.1 to 1% chitosan which is a natural film forming
polysaccharide polymer with antimicrobial and wound healing
properties;
[0053] (2) 0.1 to 3% cellulose polymers (which can act as
thickening agents) that can comprise any of the following:
hydroxyethyl cellulose, hydroxyl propyl methyl cellulose (for
example, that sold under the trade name Methocel.TM. and available
from Dow Chemical Co. of Midland, Mich.), methyl cellulose,
polyquaternium 10 (quaternized hydroxyl ethyl cellulose),
hydroxypropyl methyl-cellulose stearoxy ether (for example, that
sold under the trade name Sangelose.RTM. and available from Daido
Chemical Corporation of Osaka, Japan), or any combinations
thereof;
[0054] (3) a botanical blend that can comprise any of the
following: rosemary oil, (0.05 to 0.2%) and vetiver oil (0.01 to
0.1%), red sandalwood paste/extract (0.01 to 0.1%), orange oil (0.1
to 0.5%), plant based 1,3 propanediol (1 to 10%), benzyl alcohol
(0.5 to 2%) and any combination thereof. This botanical blend, when
used in FGZ+salicylic acid formulation, enhances the antibacterial
activity and reduces skin irritation;
[0055] (4) 0.1 to 0.5% or 0.1 to 5% calendula oil or extract, 0.1
to 0.5% or 0.1 to 5% aloe vera gel or extract or a combination
thereof, which reduces inflammation, soothes the skin, relieves the
itching, irritation and burning sensation;
[0056] (5) 0.3 to 7% emollient solvents, which can be any of the
following: 1,3 propanediol, glycerin, caprylil capryl triglyceride,
butylene glycol, octanediol, decanediol, benzyl alcohol,
octoxyglycerin, farnesol or any combination thereof;
[0057] (6) one or more alpha hydroxy acids or fruit acids, which
can be any of the following: glycolic acid, lactic acid, benzoic
acid or any combination thereof;
[0058] (7) one or more essential oils or botanical extracts, or
constituents thereof (that is, constituents of essential oils or
botanical extracts), which can be any of the following: pomegranate
oil or extract (0.3 to 1%), Grapefruit seed extract (0.3 to 1%),
lavender oil, chamomile oil, basil oil, thyme oil, thymol, menthol,
Farnesol, bakuchiol, grapefruit seed extract, jojoba oil, white tea
extract, green tea extract, resveratrol or any combination thereof.
These ingredients have antibacterial and anti-inflammatory
properties;
[0059] (8) one or more solvents e.g. water, alcohol, sorbitan mono
laurate (e.g., Tween.RTM. 20), sorbitan mono oleate (e.g.,
Tween.RTM. 80), sorbitan oleate decylglucoside, sorbitan sugar
(e.g., Poly Suga.RTM. mulse), caprylil capryl glucoside, mixture of
PEG 40 hydrogenated castor oil, trideceth-9 propyleneglycol (e.g.,
Symrise.RTM. solubilizer 660352), Peg 40 hydrogenated castor oil,
trideceth-9, water (e.g., Symrise.RTM. solubilizer 611674)
[0060] (9) a preservative, e.g., chlorhexidine, benzalkonium
chloride, phenoxyethanol, phenyl ethanol or any combination thereof
(0.1 to 1%).
[0061] In various embodiments, a composition herein can comprise
any of a number of additional ingredients, including but not
limited to the following: retinol (also known as Vitamin A1), or a
natural alternative to retinol, for example, a bakuchiol compound
available under the trade name Sytenol.RTM. from Sytheon Ltd.
(Boonton, N.J., USA); one or more poloxamers--that is, nonionic
triblock copolymers composed of a central hydrophobic chain of
chain of polyoxypropylene (poly(propylene oxide)) flanked by two
hydrophilic chains of polyoxyethylene (poly(ethylene oxide)), and
which are available under the trade name Pluronic.RTM. from BASF
Corporation (Ludwigshafen, Germany); anti-irritant or anti-itch or
antihistamic compounds, for example, synthetic avenanthramide
available under the trade name SymCalmin.RTM. from Symrise AG
(Holzminden, Germany); Vitamins, whether or not considered to be
antioxidants, for example, Vitamin A, Vitamin C, Vitamin E or
Vitamin B, e.g., Pro Vitamin B-5 compounds available under the
trade name Ritapan.RTM. from Rita Corpoation (Crystal Lake, Ill.,
USA); or a thickener, e.g., one available under the trade name
Incromine.TM. from Croda Personal Care (Snaith, East Yorkshire,
United Kingdom); or hair enhancing compositions such as that
available under the trade name Incroquat.TM. Behenyl TMS from Croda
Personal Care (Snaith, East Yorkshire, United Kingdom);
Example 1
Development of Stable FGZB Formulation
[0062] The following formulations were prepared, including varying
amounts of emulsifiers, HPMCSE polymer (S), Chitosan (C) and
combinations thereof. These formulations were evaluated for film
formation and stability.
TABLE-US-00001 Formulation Sample EC Ingredient % (w/w) Salicylic
acid 2 Base ingredient Deionized Water Q.S. to 100 Zinc gluconate
0.2 Zinc lactate 0.2 Aloe powder 0.2 Glycolic acid 0.5 Lactic acid
0.2 BTMSCB emulsifier (E) 2.5 Polawax .TM. emulsifier (E) 2.5
Chitosan (C) 0.15 Calendula extract 0.2 Alcohol denatured 10 1,3
propanediol 2 Caprylil capril triglyceride 2 Ethyl hexyl glycerin 1
Decanediol 0.5 Bisabolol 0.1 Pomegranate oil 0.5 Rosemary oil 0.1
Thymol 0.1 Menthol 0.1 Orange oil 0.2 Vetiver oil 0.02 Resveratrol
0.5 Red sandalwood extract 0.1 Chlorhexidine gluconate 0.05
TABLE-US-00002 Formulation Sample SC Ingredient % (w/w) Salicylic
acid 2 Base ingredient Deionized Water Q.S. to 100 Zinc gluconate
0.2 Zinc lactate 0.2 Aloe powder 0.2 Glycolic acid 0.5 Lactic acid
0.2 HPMCSE polymer (S) 0.5 Chitosan polymer (C) 0.15 Calendula
extract 0.2 Alcohol denatured 10 1,3 propanediol 2 Caprylil capril
triglyceride 2 Ethyl hexyl glycerin 1 Decanediol 0.5 Bisabolol 0.1
Pomegranate oil 0.5 Rosemary oil 0.1 Thymol 0.1 Menthol 0.1 Orange
oil 0.2 Vetiver oil 0.02 Resveratrol 0.5 Red sandalwood extract 0.1
Chlorhexidine gluconate 0.05
TABLE-US-00003 Formulation Sample SE-1 Ingredient % (w/w) Salicylic
acid 2 Base ingredient Deionized Water Q.S. to 100 Zinc gluconate
0.2 Zinc lactate 0.2 Aloe powder 0.2 Glycolic acid 0.5 Lactic acid
0.2 BTMSCB emulsifier (E) 2.5 Polawax .TM. emulsifier (E) 3 HPMCSE
polymer (S) 0.5 Calendula extract 0.2 Alcohol denatured 10 1,3
propanediol 2 Caprylil capril triglyceride 2 Ethyl hexyl glycerin 1
Decanediol 0.5 Bisabolol 0.1 Pomegranate oil 0.5 Rosemary oil 0.1
Thymol 0.1 Menthol 0.1 Orange oil 0.2 Vetiver oil 0.02 Resveratrol
0.5 Red sandalwood extract 0.1 Chlorhexidine gluconate 0.05
TABLE-US-00004 Formulation Sample SE-2 Ingredient % (w/w) Salicylic
acid 2 Base ingredient Deionized Water Q.S. to 100 Zinc gluconate
0.2 Zinc lactate 0.2 Aloe powder 0.2 Glycolic acid 0.5 Lactic acid
0.2 BTMSCB emulsifier (E) 2.5 Polawax .TM. emulsifier (E) 3 HPMCSE
polymer (S) 0.7 Calendula extract 0.2 Alcohol denatured 10 1,3
propanediol 2 Caprylil capril triglyceride 2 Ethyl hexyl glycerin 1
Decanediol 0.5 Bisabolol 0.1 Pomegranate oil 0.5 Rosemary oil 0.1
Thymol 0.1 Menthol 0.1 Orange oil 0.2 Vetiver oil 0.02 Resveratrol
0.5 Red sandalwood extract 0.1 Chlorhexidine gluconate 0.05
TABLE-US-00005 Formulation Sample SCE-1 Ingredient % (w/w)
Salicylic acid 2 Base ingredient Deionized Water Q.S. to 100 Zinc
gluconate 0.2 Zinc lactate 0.2 Aloe powder 0.2 Glycolic acid 0.5
Lactic acid 0.2 BTMSCB emulsifier (E) 1.5 Polawax .TM. emulsifier
(E) 1.5 HPMCSE polymer (S) 0.55 Chitosan (C) 0.3 Calendula extract
0.2 Alcohol denatured 10 1,3 propanediol 2 Caprylil capril
triglyceride 2 Ethyl hexyl glycerin 1 Decanediol 0.5 Bisabolol 0.1
Pomegranate oil 0.5 Rosemary oil 0.1 Thymol 0.1 Menthol 0.1 Orange
oil 0.2 Vetiver oil 0.02 Resveratrol 0.5 Red sandalwood extract 0.1
Chlorhexidine gluconate 0.05
TABLE-US-00006 Formulation Sample SCE-2 Ingredient % (w/w)
Salicylic acid 2 Base ingredient Deionized Water Q.S. to 100 Zinc
gluconate 0.2 Zinc lactate 0.2 Aloe powder 0.2 Glycolic acid 0.5
Lactic acid 0.2 BTMSCB emulsifier (E) 2.5 Polawax .TM. emulsifier
(E) 3 HPMCSE polymer (S) 0.5 Chitosan (C) 0.15 Calendula extract
0.2 Alcohol denatured 10 1,3 propanediol 2 Caprylil capril
triglyceride 2 Ethyl hexyl glycerin 1 Decanediol 0.5 Bisabolol 0.1
Pomegranate oil 0.5 Rosemary oil 0.1 Thymol 0.1 Menthol 0.1 Orange
oil 0.2 Vetiver oil 0.02 Resveratrol 0.5 Red sandalwood extract 0.1
Chlorhexidine gluconate 0.05
[0063] Stability of the Formulations (EC, SC, SE-1, SE-2, SCE-1 and
SCE-2) at 7 days at 40.degree. C. is shown in FIG. 1
[0064] Conclusion: As can be seen from the above FIGURE, only
formulations containing HPMCSE polymer (S), emulsifiers and
Chitosan (SCE) resulted in a uniform gel. SE-2 formulation where S
is 0.7% and emulsifier (5.5%) was also resulted in a uniform
gel.
[0065] However, SE--which is S (0.5% and emulsifiers (5.5%), EC
which is emulsifier and Chitosan, SC which S and Chitosan were
separated and did not form a uniform gel.
[0066] Various SCE formulations where concentrations of S ranging
from 0.1 to 1% w/w, C ranging from 0.1 to 0.5% w/w, and E ranging
from 0.4 to 5 w/w were also prepared and found to be stable.
Example 2
Antibacterial Efficacy of Combination of Salicylic Acid and
Botanicals
[0067] Various botanicals, salicylic acid and combinations were
mixed in FGZ gel and antibacterial efficacy was evaluated. Results
are shown in the Tables below.
[0068] Table 1: Antibacterial Activity of Salicylic Acid and
Botanicals in FGZ Base (Zone of Inhibition Test)
TABLE-US-00007 TABLE 1 Ingredients in FGZ Base Zone of inhibition
(mm) FGZ base (control) 0 Salicylic acid 2% 1 Botanical blend 2
Botanical blend + salicylic acid 7.5
[0069] "Botanical blend" contains: pomegranate extract (0.5%),
rosemary oil (0.1%), orange oil (0.2%), vetiver oil (0.02%), red
sandalwood extract (0.1%), plant based benzyl alcohol (1%), plant
based 1,3 propanediol (2%).
[0070] Conclusion: Botanical blend synergistically enhances the
efficacy of salicylic acid.
[0071] Table 2: Antibacterial Activity (Rapidity of Kill Test
Organism S. aureus)
[0072] Rapid kill (15 seconds) test tube method described in
ASTM-E2783-1198751-1 (suspension test).
[0073] In vitro rapid-kill test was carried out according to ASTM
E2783-11; 108 CFU mL.sup.-1 microbial cultures were prepared in a
TSA media in order to determine the antimicrobial activity of acne
formulations. 0.9 mL acne formulation was kept in contact with 0.1
mL microbial cultures for 15 seconds and subsequently neutralized
using agent DE. PBS was used as a control. In this study, an the
acne product is considered effective if the log 10 reduction
exhibits 3.0 or higher.
TABLE-US-00008 TABLE 2 Log reductrion Ingredient in FGZ gel from
control growth FGZ base (control) 0 Salicylic acid 2% 2.1 Botanical
blend 1 1.2 Botanical blend 2 1.2 0.05% chlorhexidine gluconate
(preservative) 0.2 Botanical blend 1 + Salicylic acid 3.8 Botanical
blend 2 + Salicylic acid 3.8 Botanical blend 1 + Salicylic acid +
0.05% 4 Chlorhexidine
[0074] Botanical Blend 1 contains: Rosemary oil (0.1%), Orange oil
(0.2%), Vetiver oil (0.02%), Red sandalwood extract (0.1%), Benzyl
alcohol (1%), Plant based 1,3 propanediol (2%).
[0075] Botanical Blend 2 contains: Pomegranate Extract (0.5%),
Rosemary oil (0.1%), Orange oil (0.2%), Vetiver oil (0.02%), Red
sandalwood extract (0.1%), Benzyl alcohol (1%), Plant based 1,3
propanediol (2%).
[0076] Conclusion: Botanical blends in combination with Salicylic
acid show higher antibacterial efficacy.
Example 3
[0077] Various SCE-Zinc salts film (FGZ) formulation containing
salicylic acid and botanicals (FGZB) e.g. cleanser, lotion and spot
cream were prepared as below and were found to be stable and
effective.
TABLE-US-00009 HGZB Cleanser C-7 Ingredient % w/w Phase A (50-60)
Water 47.3 Zinc lactate 0.2 Zinc gluconate 0.2 Methocel 1
Polyquaternium 10 0.5 Pluronic .RTM. F-87 1.5 BTMSCB 0.2 Polawax
.TM. 0.2 Cocoamido propyl betaine 9 Glycolic acid 0.5 Lactic Acid
0.2 Sodium chloride 0.2 Sangelose .RTM. 90 L (1%) 10 Chitosan (3%)
4 Aloe 1X 3 Calendula Extract 1 Total Phase A 79 Phase B Botanical
Blend SDA 40B 15 Benzyl alcohol 1 Red Sandalwood 0.09 Salicylic
acid 1 C3 curcumin 0.01 Octanediol 0.5 Ethylhexyl Glycerin 1
Phenoxy ethanol 0.7 Farnasol 0.3 Thymol 0.1 Menthol 0.1 CHG (20%) 1
Orange oil 0.2 Total Phase B 21
TABLE-US-00010 HGZB Cleanser C-8 Ingredient % w/w Phase A (50-60)
Water 46.7 Zinc lactate 0.2 Zinc gluconate 0.2 Methocel 1
Polyquaternium 10 0.5 Pluronic .RTM. F-87 1.5 BTMSCB 0.5 Polawax
.TM. 0.5 Jojoba oil 2 Cocoamido propyl betaine 9 Glycolic acid 0.5
Lactic Acid 0.2 Sodium chloride 0.2 Sangelose .RTM. 90 L(1%) 10
Chitosan (3%) 4 Aloe 1X 3 Calendula Extract 1 Total Phase A 79
Phase B Botanical Blend SDA 40B 15 Benzyl alcohol 1 Red Sandalwood
0.09 Salicylic acid 1 C3 curcumin 0.01 Octanediol 0.5 Ethylhexyl
Glycerin 1 Phenoxy ethanol 0.7 Farnasol 0.3 Thymol 0.1 Menthol 0.1
CHG (20%) 1 Orange oil 0.2 Total Phase B 21
TABLE-US-00011 HGZB Cleanser F-3 pH 4.5 Ingredient % w/w Phase A
(50-60) Water 57.8 Zinc lactate 0.2 Zinc gluconate 0.1 Panthenol
0.5 Pluronic .RTM. F-87 1.5 BTMSCB 0.1 Polawax .TM. 0.1 Cocoamido
propyl betaine 11 Glycolic acid 0.5 Lactic Acid 0.2 Total Phase A
72 Phase B Botanical Blend Zemea .RTM. propanediol 3 SDA 40B
denatured alcohol 10 Benzyl alcohol 1 Salicylic acid 1 Decanediol
0.5 Ethylhexyl Glycerin 1 Phenoxy ethanol 0.7 Aloe Vera 1X 2
Farnasol 0.3 CHG (20%) 1 Orange oil 0.5 Incromine .RTM. Oxide 2
Sangelose .RTM. 60L (1% in 1:1 5 mix of SDA-40 & Water) Total
Phase B 28 100
TABLE-US-00012 HGZB Cleanser F-4 pH 4 5 Ingredient % w/w Phase A
(50-60) Water 59.3 Zinc lactate 0.2 Zinc gluconate 0.1 Panthenol
0.5 Pluronic .RTM. F-87 2 BTMSCB 0.1 Polawax .TM. 0.1 Cocoamido
propyl betaine 11 Glycolic acid 0.5 Lactic Acid 0.2 Total Phase A
74 Phase B Botanical Blend Zemea .RTM. propanediol 3 SDA 40B 10
Benzyl alcohol 1 Salicylic acid 1 Decanediol 0.5 Ethylhexyl
Glycerin 1 Phenoxy ethanol 0.7 Aloe Vera 1X 2 Farnasol 0.3 CHG
(20%) 1 Orange oil 0.5 Sangelose .RTM. 60L (1% in 1:1 5 mix of
SDA-40 & Water) Total Phase B 26
TABLE-US-00013 HGZB Cleanser F-5 pH 4.5 Ingredient % w/w Phase A
(50-60) Water 58.75 Zinc lactate 0.2 Zinc gluconate 0.1 Panthenol
0.5 Pluronic .RTM. F-87 2 BTMSCB 0.1 Polawax .TM. 0.1 Cocoamido
propyl betaine 11 Glycolic acid 0.5 Lactic Acid 0.2 Total Phase A
73.45 Phase B Botanical Blend Zemea .RTM. propanediol 3 SDA 40B 10
Benzyl alcohol 1 Salicylic acid 1 Decanediol 0.5 Ethylhexyl
Glycerin 1 Phenoxy ethanol 0.7 Aloe Vera 1X 2 Farnasol 0.3 Lemon
extract 0.5 Thymol 0.05 CHG (20%) 1 Orange oil 0.5 Sangelose .RTM.
60L (1% in 1:1 5 mix of SDA-40 & Water) Total Phase B 26.55
100
TABLE-US-00014 HGZB Cleanser F-7 pH 4.0 Ingredient % w/w Phase A
(50-60) Water 49.95 Sodium Chloride 0.4 Hydroxyethylcellulose 0.2
Zinc lactate 0.2 Zinc gluconate 0.1 Panthenol 0.5 Pluronic .RTM.
F-87 2.5 BTMSCB 0.1 Polawax .TM. 0.1 Cocoamido propyl betaine 15
Glycolic acid 1 Lactic Acid 0.2 Sangelose .RTM. 60L (1%) 5 Total
Phase A 75.25 Orange Flavor 1 Phase B Botanical Blend Zemea .RTM.
propanediol 3. SDA 40B 10 Benzyl alcohol 1 Salicylic acid 1
Decanediol 0.5 Ethylhexyl Glycerin 1 Phenoxy ethanol 0.7 Aloe Vera
1X 2 Farnasol 0.3 Lemon extract 0.5 Thymol 0.05 CHG (20%) 1 White
tea extract 0.5 Resveratrol extract 0.5 Vitamin E 0.1 Vitamin C 0.1
Orange oil 0.5 Tween .RTM. 20 1 Total Phase B 23.75 100
TABLE-US-00015 HGZB Cleanser F-8 pH 4.0 Ingredient % w/w Phase A
(50-60) Water 49.81 Sodium Chloride 0.4 Ucare .RTM.
polyquaternium-10 emulsifier 0.5 Zinc lactate 0.2 Zinc gluconate
0.1 Panthenol 0.5 Pluronic .RTM. F-87 2.5 BTMSCB 0.1 Polawax .TM.
0.1 Cocoamido propyl betaine 15 Glycolic acid 1 Lactic Acid 0.2
Sangelose .RTM. 60L (1%) 5 Total Phase A 75.41 Orange Flavor 1
Phase B Botanical Blend Zemea .RTM. propanediol 3 SDA 40B 10 Benzyl
alcohol 1 Salicylic acid 1 Decanediol 0.5 Ethylhexyl Glycerin 1
Phenoxy ethanol 0.7 Aloe Vera 1X 2 Farnasol 0.3 Lemon extract 0.5
Thymol 0.05 CHG (20%) 1 White tea extract 0.5 Resveratrol extract
0.5 Vitamin E 0.02 Vitamin C 0.02 Orange oil 0.5 Tween .RTM. 20 1
Total Phase B 23.59 100
TABLE-US-00016 HGZB Cleanser F-9 pH 4.0 Ingredient % w/w Phase A
(50-60) Water 40.55 Sodium Chloride 0.4 Zinc lactate 0.2 Zinc
gluconate 0.1 Panthenol 0.5 Pluronic .RTM. F-87 3 BTMSCB 0.1
Polawax .TM. 0.1 Cocoamido propyl betaine 15 Glycolic acid 1 Lactic
Acid 0.2 Sangelose .RTM. 60L (1%) 10 Total Phase A 71.15 Orange
Flavor 0.5 Phase B Botanical Blend Zemea .RTM. propanediol 3 SDA
40B 15 Benzyl alcohol 1 Salicylic acid 1 Decanediol 0.5 Ethylhexyl
Glycerin 1 Phenoxy ethanol 0.7 Aloe Vera 1X 2 Farnasol 0.3 Lemon
extract 0.5 Orange oil 0.3 Thymol 0.05 CHG (20%) 1 White tea
extract 0.5 Resveratrol extract 0.5 Tween .RTM. 20 1 Total Phase B
28.35 100
TABLE-US-00017 HGZB Cleanser F-13 pH 4.0 Ingredient % w/w Phase A
(50-60) Water 36.95 Zinc lactate 0.2 Zinc gluconate 0.1 Panthenol
0.5 Pluronic .RTM. F-87 3 BTMSCB 0.2 Polawax .TM. 0.2 Cocoamido
propyl betaine 15 Glycolic acid 1 Lactic Acid 0.2 Total Phase A
57.35 Orange Flavor 0.5 NaOH (10N) 1.3 Phase B Botanical Blend
Zemea .RTM. propanediol 3 Benzyl alcohol 1 Salicylic acid 1
Ethylhexyl Glycerin 1 Phenoxy ethanol 0.7 Aloe Vera 1X 2 Farnasol
0.3 Lemon extract 0.5 Thymol 0.05 CHG (20%) 1 Green tea extract 1
Orange oil 0.3 Tween .RTM. 20 1 SDA 40B 18 Sangelose .RTM. 90L (1%)
10 Total Phase B 40.85 100
TABLE-US-00018 HGZB Cleanser F-14 pH 4.0 Ingredient % w/w Phase A
(65-70) Water 36.22 Zinc lactate 0.4 Zinc gluconate 0.2 Panthenol
0.5 Pluronic .RTM. F-87 3 Glycolic acid (70% Solution) 1.43 Lactic
Acid 0.2 BTMSCB 0.2 Polawax .TM. 0.2 Sangelose .RTM. 90L (1%) 10
Cocoamido propyl betaine 15 Total Phase A 67.35 Orange Fragrance
#180494 0.5 NaOH(10N) 1.3 Phase B Botanical Blend SDA 40B 18 Zemea
.RTM. propanediol 3 Thymol 0.05 Benzyl alcohol 1 Ethylhexyl
Glycerin 1 Phenoxy ethanol 0.7 Salicylic acid 1 Aloe Vera 1X 2
Farnasol 0.3 Lemon extract 0.5 CHG (20%) 1 Green tea extract 1
Orange oil 0.3 Tween .RTM. 20 1 Total Phase B 30.85 100
TABLE-US-00019 HGZB Cleanser F-15 pH 4.0 Ingredient % w/w Phase A
(65-70) Water 39.22 Zinc lactate 0.4 Zinc gluconate 0.2 Panthenol
0.5 Glycolic acid (70% Solution) 1.43 Lactic Acid 0.2 BTMSCB 0.2
Polawax .TM. 0.2 Sangelose .RTM. 90L (1%) 10 Cocoamido propyl
betaine 15 Total Phase A 67.35 Orange Fragrance #180494 0.5 NaOH
(10N) 1.3 Phase B Botanical Blend SDA 40B 18 Zemea .RTM.
propanediol 3 Thymol 0.05 Benzyl alcohol 1 Ethylhexyl Glycerin 1
Phenoxy ethanol 0.7 Salicylic acid 1 Aloe Vera 1X 2 Farnasol 0.3
Lemon extract 0.5 CHG (20%) 1 Green tea extract 1 Orange oil 0.3
Tween .RTM. 20 1 Total Phase B 30.85 100
TABLE-US-00020 HGZB Cleanser F-16 pH 4.0 Ingredient % w/w Phase A
(65-70) Water 38.72 Zinc lactate 0.4 Zinc gluconate 0.2 Panthenol
0.5 Glycolic acid (70% Solution) 1.43 Xanthan Gum 0.5 Lactic Acid
0.2 BTMSCB 0.2 Polawax .TM. 0.2 Sangelose .RTM. 90L (1%) 10
Cocoamido propyl betaine 15 Total Phase A 67.35 Orange Fragrance
#180494 0.5 NaOH (10N) 1.3 Phase B Botanical Blend SDA 40B 18 Zemea
.RTM. propanediol 3 Thymol 0.05 Benzyl alcohol 1 Ethylhexyl
Glycerin 1 Phenoxy ethanol 0.7 Salicylic acid 1 Aloe Vera 1X 2
Farnasol 0.3 Lemon extract 0.5 CHG (20%) 1 Green tea extract 1
Orange oil 0.3 Tween .RTM. 20 1 Total Phase B 30.85 100
TABLE-US-00021 FGZB Lotion G-1 Ingredient % w/w Phase A (50-60)
Water 17.63 Zinc lactate 0.2 Zinc gluconate 0.2 D-L panthenol 0.5
Lactic acid 0.2 Glycolic acid 0.5 Aloe 100X 1 BTMSCB 1.5 Polawax
.TM. NF 1.5 Jojoba oil (Viva) 2 Chitosan 3% 8 Calendula extract
(100%/oil) 0.2 Cool to 30-40.degree. C. Phase B Sangelose .RTM. 90
L 1% 50 Add Phase B to Phase A Total Phase A + B 83.7 Phase C
Botanical Blend Zemea .RTM. propanediol 7 Ethyl Hexyl Glycerin 1
butylene glycol 2 salicylic acid 2 Bisabolol 0.1 Phenoxyethanol 0.7
Pomegranate oil 0.3 Rosemary oil 0.1 orange oil 0.2 Vetiver oil
0.02 Sorbitan monolaurate 0.5 CHG (20%) 0.25 Vitamin E 0.2 Vitamin
C 0.1 silicone Shinetsu KF6038 1 Red sandalwood extract 0.1
Resveratrol BT 0.5 white tea extract 0.5 Total Phase C 16.57
TABLE-US-00022 FGZB Lotion G-3 Ingredient % w/w Phase A (50-60)
Water 19.03 Zinc lactate 0.2 Zinc gluconate 0.2 Lactic acid 0.2
Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 1 Polawax .TM. NF 1 Cool to
30-40.degree. C. Phase B Sangelose .RTM. 90 L 1% 52 Add Phase B to
Phase A Chitosan 3% 10 Calendula extract (100%/oil) 1 Total Phase A
+ B 85.33 Phase C Botanical Blend Zemea .RTM. propanediol 5 Ethyl
Hexyl Glycerin 1 butylene glycol 3 Benzyl alcohol 0.5 salicylic
acid 2 Bisabolol 0.1 Decanediol 0.5 Farnesol 0.3 Pomegranate oil
0.5 Rosemary oil 0.1 Orange oil 0.1 Vetiver oil 0.02 CHG (20%) 0.25
Vitamin E 0.2 Red sandalwood extract 0.1 Resveratrol BT 0.5 White
tea extract 0.5 Total Phase C 14.67
TABLE-US-00023 FGZB Lotion G-3A Ingredient % w/w Phase A (50-60)
Water 17.03 Zinc lactate 0.2 Zinc gluconate 0.2 Lactic acid 0.2
Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 1.0 Polawax .TM. NF 1.0
Cupuacu Butter 2.0 Cool to 30-40.degree. C. Phase B Sangelose .RTM.
90 L 1% 52 Add Phase B to Phase A Chitosan 3% 10 Calendula extract
(100%/oil) 1 Total Phase A + B 85.33 Phase C Botanical Blend Zemea
.RTM. propanediol 5 Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl
alcohol 0.5 salicylic acid 2 Bisabolol 0.1 Decanediol 0.5 Farnesol
0.3 Pomegranate oil 0.5 Rosemary oil 0.1 Orange oil 0.1 Vetiver oil
0.02 CHG (20%) 0.25 Vitamin E 0.2 Red sandalwood extract 0.1
Resveratrol BT 0.5 White tea extract 0.5 Total Phase C 14.67
TABLE-US-00024 FGZB Lotion G-3B Ingredient % w/w Phase A (50-60)
Water 18.03 Zinc lactate 0.2 Zinc gluconate 0.2 Lactic acid 0.2
Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 1.5 Polawax .TM. NF 1.5 Cool
to 30-40.degree. C. Phase B Sangelose .RTM. 90 L 1% 52 Add Phase B
to Phase A Chitosan 3% 10 Calendula extract (100%/oil) 1 Total
Phase A + B 85.33 Phase C Botanical Blend Zemea .RTM. propanediol 5
Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl alcohol 0.5
salicylic acid 2 Bisabolol 0.1 Decanediol 0.5 Farnesol 0.3
Pomegranate oil 0.5 Rosemary oil 0.1 Orange oil 0.1 Vetiver oil
0.02 CHG (20%) 0.25 Vitamin E 0.2 Red sandalwood extract 0.1
Resveratrol BT 0.5 White tea extract 0.5 Total Phase C 14.67
TABLE-US-00025 FGZB Lotion G-3C Ingredient % w/w Phase A (50-60)
Water 18.03 Zinc lactate 0.2 Zinc gluconate 0.2 Lactic acid 0.2
Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 1 Polawax .TM. NF 1 Cool to
30-40.degree. C. Phase B Sangelose .RTM. 90 L 1% 52 Add Phase B to
Phase A Chitosan 3% 10 Calendula extract (100%/oil) 1 Total Phase A
+ B 84.24 Phase C Botanical Blend Zemea .RTM. propanediol 5 Ethyl
Hexyl Glycerin 1 butylene glycol 3 Benzyl alcohol 0.5 salicylic
acid 2 Bisabolol 0.1 Decanediol 0.5 Farnesol 0.3 Pomegranate oil
0.5 Rosemary oil 0.1 Orange oil 0.1 Vetiver oil 0.02 CHG (20%) 0.25
Vitamin E 0.2 Red sandalwood extract 0.1 Resveratrol BT 0.5 White
tea extract 0.5 Silicone KF 6038 1.0 Total Phase C 15.67
TABLE-US-00026 FGZB Lotion G-4 Ingredient % w/w Phase A (50-60)
Water 15.03 Zinc lactate 0.2 Zinc gluconate 0.2 Lactic acid 0.2
Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 1.5 Polawax .TM. NF 1.5
Cupuacu Butter 2 Cool to 30-40.degree. C. Phase B Sangelose .RTM.
90 L 1% 52 Add Phase B to Phase A Chitosan 3% 10 Calendula extract
(100%/oil) 1 Total Phase A + B 84.33 Phase C Botanical Blend Zemea
.RTM. propanediol 5 Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl
alcohol 0.5 salicylic acid 2 Bisabolol 0.1 Decanediol 0.5 Farnesol
0.3 Pomegranate oil 0.5 Rosemary oil 0.1 Orange oil 0.1 Vetiver oil
0.02 CHG (20%) 0.25 Vitamin E 0.2 Red sandalwood extract 0.1
Resveratrol BT 0.5 White tea extract 0.5 Silicone KF6038 1 Total
Phase C 15.67
TABLE-US-00027 FGZB Lotion G-5A Ingredient % w/w Phase A (50-60)
Water 15.69 Zinc lactate 0.2 Zinc gluconate 0.2 Lactic acid 0.2
Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 1.5 Polawax .TM. NF 1.5
Cupuacu Butter 2 Phase B Sangelose .RTM. 90 L 1% 52 Chitosan 3% 10
Calendula extract (100%/oil) 1 Total Phase A + B 84.99 Phase C
Botanical Blend Zemea .RTM. propanediol 5 Ethyl Hexyl Glycerin 1
butylene glycol 3 Benzyl alcohol 0.5 Salicylic acid 2 Bisabolol 0.1
Decanediol 0.5 Farnesol 0.3 Pomegranate oil 0.5 Rosemary oil 0.1
Orange oil 0.5 Vetiver oil 0.01 CHG (20%) 0.25 Vitamin E 0.1
Vitamin C 0.1 Red sandalwood extract (10%) 0.05 Resveratrol BT 0.5
White Tea Ext BT 0.5 Total Phase C 15.01 100
TABLE-US-00028 FGZB Lotion G-6 Ingredient % w/w Phase A (50-60)
Water 14.2 Zinc lactate 0.2 Zinc gluconate 0.2 Panthenol 0.5 Lactic
acid 0.2 Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 1.5 Polawax .TM. NF
1.5 Cupuacu Butter 2 Phase B Sangelose .RTM. 90 L 1% 52 Chitosan 5%
10 Calendula extract (100%/oil) 1 Total Phase A + B 84 Orange Cream
Flavor 1 Phase C Botanical Blend Zemea .RTM. propanediol 4.5 Ethyl
Hexyl Glycerin 1 butylene glycol 3 Benzyl alcohol 0.5 Salicylic
acid 2 Bisabolol 0.1 Decanediol 0.5 Farnesol 0.3 Pomegranate
Extract 0.5 Lemon extract 0.5 Thymol 0.05 Rosemary oil 0.1 Orange
oil 0.3 CHG (20%) 0.25 Vitamin E 0.1 Vitamin C 0.1 Resveratrol BT
0.5 Witch Hazel (5% Concentrate) 0.2 White Tea Ext BT 0.5 Total
Phase C 15 100
TABLE-US-00029 FGZB Lotion G-7 Ingredient % w/w Phase A (50-60)
Water 11.15 Zinc lactate 0.2 Zinc gluconate 0.2 Panthenol 0.5
Lactic acid 0.2 Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 2 Polawax
.TM. NF 2 Cupuacu Butter 2 Sangelose .RTM. 90 L 1% 52 Chitosan 5%
10 Calendula extract (100%) 1 Total Phase A 81.95 Orange Cream
Flavor 1 NaOH (10N) 2.05 Phase B Botanical Blend Zemea .RTM.
propanediol 4.5 Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl
alcohol 0.5 Salicylic acid 2 Bisabolol 0.1 Decanediol 0.5 Farnesol
0.3 Pomegranate Extract 0.5 Lemon extract 0.5 Thymol 0.05 Rosemary
oil 0.1 Orange oil 0.3 CHG (20%) 0.25 Vitamin E 0.1 Vitamin C 0.1
Resveratrol BT 0.5 Witch Hazel (5% Concentrate) 0.2 White Tea Ext
BT 0.5 Total Phase B 15 100
TABLE-US-00030 FGZB Lotion G-8 Ingredient % w/w Phase A (50-60)
Water 10.8 Zinc lactate 0.2 Zinc gluconate 0.2 Panthenol 0.5 Lactic
acid 0.2 Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 2 Polawax .TM. NF 2
Sangelose .RTM. 90 L 1% 52 Chitosan 5% 12 Calendula extract (100%)
0.5 Total Phase A 80.55 Orange Cream Flavor 0.25 NaOH (10N) 2.05
Phase B Botanical Blend Zemea .RTM. propanediol 4.5 Ethyl Hexyl
Glycerin 1 butylene glycol 3 Benzyl alcohol 0.5 Salicylic acid 2
Bisabolol 0.1 Decanediol 0.5 Farnesol 0.3 Grapefruit seed Extract
0.5 Pomegranate Extract 0.5 Lemon extract 0.5 Thymol 0.05 Rosemary
oil 0.1 Orange oil 0.3 CHG (20%) 0.25 Licorice Extract 0.5
Cranberry seed oil 0.5 Vitamin C 0.1 Resveratrol BT 0.5 Witch Hazel
(5%) 0.4 white tea extract 0.5 Total Phase B 16.6 100
TABLE-US-00031 FGZB Lotion G-8M pH 4.6 Ingredient % w/w Phase A
(50-60) Water 63.30 Zinc lactate 0.2 Zinc gluconate 0.2 Panthenol
0.5 Lactic acid 0.2 Glycolic acid 0.5 Aloe 100X 0.2 Sangelose .RTM.
90 L 0.5 BTMSCB 2 Polawax .TM. NF 2 Chitosan 5% 10 Calendula
extract (100%) 1 Total Phase A 80.8 Orange Cream Flavor 0.25 NaOH
(10N) 2.05 Phase B Botanical Blend Zemea .RTM. propanediol 4.5
Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl alcohol 0.5
Salicylic acid 2 Bisabolol 0.1 Decanediol 0.5 Farnesol 0.3
Grapefruit seed Extract 0.5 Pomegranate Extract 0.5 Lemon extract
0.5 Thymol 0.05 Basil oil 0.1 Rosemary oil 0.1 Orange oil 0.2 CHG
(20%) 0.25 Licorice Extract 0.5 Cranberry seed oil 0.5 Vitamin C
0.1 Resveratrol BT 0.5 Witch Hazel (5%) 0.4 Green Tea Ext 1 Total
Phase B 17.1 100
TABLE-US-00032 FGZB Lotion G-11 Ingredient % w/w Phase A (65-70)
Water 9.64 Zinc lactate 0.4 Zinc gluconate 0.4 Panthenol 0.5 Lactic
acid 0.2 Glycolic acid (70% Solution) 0.71 BTMSCB 0.5 Polawax .TM.
NF 0.5 hydroxyethylcellulose 1.5 Sangelose .RTM. 90 L (1%) 50
Stearyl Alcohol 1 Chitosan (3%) 13 Aloe 100X 1 Calendula extract
(100%) 0.5 Total Phase A 79.85 Orange Cream Flavor #180491 1 NaOH
(10N) 2.05 Phase B Botanical Blend Zemea .RTM. propanediol 4 Thymol
0.05 Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl alcohol 0.5
Salicylic acid 2 Decanediol 0.5 Bisabolol 0.1 Farnesol 0.3
Grapefruit seed Extract 0.5 Pomegranate Extract 0.5 Lemon extract
0.5 Basil oil 0.1 Rosemary oil 0.1 Orange oil 0.2 CHG (20%) 0.25
Licorice Extract 0.5 Cranberry seed oil 0.5 Vitamin C 0.1
Resveratrol 0.5 Witch Hazel (5%) 0.4 Green Tea Ext 1 Frankincense
oil 0.5 Total Phase B 17.1 100
TABLE-US-00033 FGZB Lotion G-12 Ingredient % w/w Phase A (65-70)
Water 29.64 Zinc lactate 0.4 Zinc gluconate 0.4 Panthenol 0.5
Lactic acid 0.2 Glycolic acid (70% Solution) 0.71 BTMSCB 0.5
Polawax .TM. NF 0.5 hydroxyethylcellulose 1.5 Sangelose .RTM. 90 L
(1%) 30 Stearyl Alcohol 1 Chitosan (3%) 13 Aloe 100X 1 Calendula
extract (100%) 0.5 Total Phase A 79.85 Orange Cream Flavor #180491
1 NaOH (10N) 2.05 Phase B Botanical Blend Zemea .RTM. propanediol 4
Thymol 0.05 Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl alcohol
0.5 Salicylic acid 2 Decanediol 0.5 Bisabolol 0.1 Farnesol 0.3
Grapefruit seed Extract 0.5 Pomegranate Extract 0.5 Lemon extract
0.5 Basil oil 0.1 Rosemary oil 0.1 Orange oil 0.2 CHG (20%) 0.25
Licorice Extract 0.5 Cranberry seed oil 0.5 Vitamin C 0.1
Resveratrol 0.5 Witch Hazel (5%) 0.4 Green Tea Ext 1 Frankincense
oil 0.5 Total Phase B 17.1 100
TABLE-US-00034 FGZB Lotion G-19 Ingredient % w/w Phase A (65-70)
Water 13.14 Zinc lactate 0.4 Zinc gluconate 0.4 Panthenol 0.5
Lactic acid 0.2 Glycolic acid (70% Solution) 0.71 BTMSCB 0.5
Polawax .TM. NF 0.5 Stearyl Alcohol 1 HEC 1 Sangelose .RTM. 90 L
(1%) 50 Chitosan (3%) 10 Aloe 100X 1 Calendula extract (100%) 0.5
Total Phase A 79.85 Orange Cream Flavor #180491 1 NaOH (10N) 2.05
Phase B Botanical Blend Zemea .RTM. propanediol 4 Thymol 0.05 Ethyl
Hexyl Glycerin 1 butylene glycol 3 Benzyl alcohol 0.5 Salicylic
acid 2 Decanediol 0.5 Bisabolol 0.1 Farnesol 0.3 Grapefruit seed
Extract 0.5 Pomegranate Extract 0.5 Lemon extract 0.5 Basil oil 0.1
Rosemary oil 0.1 Orange oil 0.2 CHG (20%) 0.25 Licorice Extract 0.5
Cranberry seed oil 0.5 Vitamin C 0.1 Resveratrol 0.5 Witch Hazel
(5%) 0.4 Green Tea Ext 1 Frankincense oil 0.5 Total Phase B 17.1
100
TABLE-US-00035 FGZB Lotion G-20 Ingredient % w/w Phase A (65-70)
Water 14.64 Zinc lactate 0.4 Zinc gluconate 0.4 Panthenol 0.5
Lactic acid 0.2 Glycolic acid (70% Solution) 0.71 BTMSCB 0.5
Polawax .TM. NF 0.5 Stearyl Alcohol 1 Sangelose .RTM. 90 L (1%) 50
Chitosan (3%) 10 Aloe 100X 1 Calendula extract (100%) 0.5 Total
Phase A 80.35 Orange Cream Flavor #180491 1 NaOH (10N) 2.05 Phase B
Botanical Blend Zemea .RTM. propanediol 4 Thymol 0.05 Ethyl Hexyl
Glycerin 1 butylene glycol 3 Benzyl alcohol 0.5 Salicylic acid 2
Decanediol 0.5 Bisabolol 0.1 Farnesol 0.3 Grapefruit seed Extract
0.5 Pomegranate Extract 0.5 Lemon extract 0.5 Basil oil 0.1
Rosemary oil 0.1 Orange oil 0.2 CHG (20%) 0.25 Licorice Extract 0.5
Vitamin C 0.1 Resveratrol 0.5 Witch Hazel (5%) 0.4 Green Tea Ext 1
Frankincense oil 0.5 Total Phase B 16.6 100
TABLE-US-00036 Z clear Anti Acne Lotion G-21 Ingredient % w/w Water
29.14 Zinc lactate 0.4 Zinc gluconate 0.4 Panthenol 0.5 Lactic acid
0.2 Glycolic acid (70% Solution) 0.71 Incroquat .TM. BTMS 0.5
Polawax .TM. NF 0.5 hydroxyethylcellulose 2 Sangelose .RTM. 90 L
(1%) 30 Stearyl Alcohol 1 Chitosan (3%) 13 Aloe 100X 1 Calendula
extract (100%) 0.5 Total Phase A 79.85 Orange Cream Flavor #180491
1 NaOH (10N) 2.05 Phase B Botanical Blend Zemea .RTM. propanediol 4
Thymol 0.05 Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl alcohol
0.5 Salicylic acid 2 Decanediol 0.5 Bisabolol 0.1 Farnesol 0.3
Grapefruit seed Extract 0.5 Pomegranate Extract 0.5 Lemon extract
0.5 Basil oil 0.1 Rosemary oil 0.1 Orange oil 0.2 CHG (20%) 0.25
Licorice Extract 0.5 Cranberry seed oil 0.5 Vitamin C 0.1
Resveratrol 0.5 Witch Hazel (5%) 0.4 Green Tea Ext 1 Frankincense
oil 0.5 Total Phase B 17.1 100
TABLE-US-00037 FGZB Lotion G-22 Ingredient % w/w Water 28.64 Zinc
lactate 0.4 Zinc gluconate 0.4 Panthenol 0.5 Lactic acid 0.2
Glycolic acid (70% Solution) 0.71 Incroquat .TM. BTMS 0.5 Polawax
.TM. NF 0.5 hydroxyethylcellulose 2 Sangelose .RTM. 90 L (1%) 30
Stearyl Alcohol 1 Chitosan (3%) 13 Xanthan Gum 0.5 Aloe 100X 1
Calendula extract (100%) 0.5 Total Phase A 79.85 Orange Cream
Flavor #180491 1 NaOH (10N) 2.05 Phase B Botanical Blend Zemea
.RTM. propanediol 4 Thymol 0.05 Ethyl Hexyl Glycerin 1 butylene
glycol 3 Benzyl alcohol 0.5 Salicylic acid 2 Decanediol 0.5
Bisabolol 0.1 Farnesol 0.3 Grapefruit seed Extract 0.5 Pomegranate
Extract 0.5 Lemon extract 0.5 Basil oil 0.1 Rosemary oil 0.1 Orange
oil 0.2 CHG (20%) 0.25 Licorice Extract 0.5 Cranberry seed oil 0.5
Vitamin C 0.1 Resveratrol 0.5 Witch Hazel (5%) 0.4 Green Tea Ext 1
Frankincense oil 0.5 Total Phase B 17.1 100
TABLE-US-00038 FGZB Spot Gel B2 Ingredient % w/w Phase A (50-60)
Water 14 Zinc lactate 0.2 Zinc gluconate 0.2 Aloe powder 0.2
Methocel .TM. cellulose ether 0.5 EDTA 0.1 Panthenol 0.5 Lactic
acid 0.2 Glycolic acid 0.5 BTMSCB 2.5 Polawax .TM. NF 3 Sangelose
.RTM. 90 L Gel (1%) 50 Chitosan Gel (3%) 5 calendula ext(100%)/oil
0.3 Vitamin E 0.2 Vitamin C 0.1 Total Phase A 77.5 Phase B
Botanical Blend Alcohol denatured 10 Zemea .RTM. propanediol 2
Ethyl Hexyl Glycerin 1 Caprylil Capril Triglyceride 2 Sytenol .RTM.
0.5 Benzyl alcohol 1 Salicylic acid 2 Decanediol 0.5 Farnesol 0.3
Bisabolol 0.1 Phenoxyethanol 0.7 Pomegranate oil 0.5 Thymol 0.1
Menthol 0.1 Rosemary oil 0.1 orange oil 0.2 Vetiver oil 0.02
Sorbitan monolaurate 0.5 Resveratrol 0.5 CHG (20%) 0.25 red
sandalwood extract 0.1 silicone Shinetsu KF6038 0.5 Total Phase B
22.47
TABLE-US-00039 FGZB Spot Gel B3 Topical Gel Ingredient % w/w
Deionized Water Q.S. to 100 Zinc gluconate 0.2 Zinc lactate 0.2
Aloe powder 0.2 Glycolic acid 0.5 Lactic acid 0.2 BTMSCB emulsifier
2.5 Polawax .TM. emulsifier 2.5 Jojoba oil 2 Cool to 30-40.degree.
C. HPMCSE polymer (1%) 50 Chitosan polymer (3%) 10 Calendula
extract 0.2 1,3 propanediol 7 Caprylil capril triglyceride 2 Ethyl
hexyl glycerin 1 Benzyl alcohol 1 Salicylic acid 2 Decanediol 0.5
Bisabolol 0.1 Bakuchiol 0.5 Pomegranate Extract 0.5 Rosemary oil
0.1 Thymol 0.1 Menthol 0.1 Orange oil 0.2 Vetiver oil 0.02
Resveratrol 0.5 Red sandalwood extract 0.1 Chlorhexidine gluconate
(20%) 0.25 Silicone Shin Etsu .RTM. KF6038 1
TABLE-US-00040 FGZB Spot Gel B4 Topical Gel Ingredient % w/w
Deionized Water Q.S. to 100 Zinc gluconate 0.2 Zinc lactate 0.2
Aloe powder 0.2 Glycolic acid 0.5 Lactic acid 0.2 BTMSCB emulsifier
2.5 Polawax .TM. emulsifier 2.5 Jojoba oil 2 Cool to 30-40.degree.
C. HPMCSE polymer (1%) 50 Chitosan polymer (3%) 10 Calendula
extract 0.2 1,3 propanediol 7 Butylene glycol 2 Ethyl hexyl
glycerin 1 Benzyl alcohol 1 Bakuchiol 0.5 Decanediol 0.5 Bisabolol
0.1 Pomegranate extract 0.5 Rosemary oil 0.1 Thymol 0.1 Menthol 0.1
Orange oil 0.2 Vetiver oil 0.1 Resveratrol 0.2 Red sandalwood
extract 0.02 Chlorhexidine gluconate (20%) 0.25 Silicone Shin Etsu
.RTM. KF 6038 Qs to 100 1
TABLE-US-00041 FGZB Spot Gel B5 Topical Gel Ingredient % w/w Phase
A (50-60) Water 13.53 Zinc lactate 0.2 Zinc gluconate 0.2 Lactic
acid 0.2 Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 2 Polawax .TM. NF 2
Cupuacu Butter 2 Cool to 30-40.degree. C. Phase B Sangelose .RTM.
90 L 1% 52 Add Phase B to Phase A Chitosan 3% 10 Calendula extract
(100%/oil) 1 Total Phase A + B 83.83 Phase C Botanical Blend Zemea
.RTM. propanediol 5 Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl
alcohol 0.5 salicylic acid 2 Bisabolol 0.1 Bakuchiol 0.5 Decanediol
0.5 Farnesol 0.3 Pomegranate oil 0.5 Rosemary oil 0.1 Orange oil
0.1 Vetiver oil 0.02 CHG (20%) 0.25 Vitamin E 0.2 Red sandalwood
extract 0.1 Resveratrol BT 0.5 White tea extract 0.5 Silicone
KF6038 1.0 Total Phase C 16.17
TABLE-US-00042 FGZB Spot Gel B5-A Topical Gel Ingredient % w/w
Phase A (50-60) Water 16.53 Zinc lactate 0.2 Zinc gluconate 0.2
Lactic acid 0.2 Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 2 Polawax
.TM. NF 2 Cool to 30-40.degree. C. Phase B Sangelose .RTM. 90 L 1%
52 Add Phase B to Phase A Chitosan 3% 10 Calendula extract
(100%/oil) 1 Total Phase A + B 84.83 Phase C Botanical Blend Zemea
.RTM. propanediol 5 Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl
alcohol 0.5 salicylic acid 2 Bisabolol 0.1 Bakuchiol 0.5 Decanediol
0.5 Farnesol 0.3 Pomegranate oil 0.5 Rosemary oil 0.1 Orange oil
0.1 Vetiver oil 0.02 CHG (20%) 0.25 Vitamin E 0.2 Red sandalwood
extract 0.1 Resveratrol BT 0.5 White tea extract 0.5 Total Phase C
15.17
TABLE-US-00043 FGZB Spot Gel B5-B Topical Gel Ingredient % w/w
Phase A (50-60) Water 17.03 Zinc lactate 0.2 Zinc gluconate 0.2
Lactic acid 0.2 Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 2 Polawax
.TM. NF 2 Cool to 30-40.degree. C. Phase B Sangelose .RTM. 90 L 1%
52 Add Phase B to Phase A Chitosan 3% 10 Calendula extract
(100%/oil) 1 Total Phase A + B 85.33 Phase C Botanical Blend Zemea
.RTM. propanediol 5 Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl
alcohol 0.5 salicylic acid 2 Bisabolol 0.1 Decanediol 0.5 Farnesol
0.3 Pomegranate oil 0.5 Rosemary oil 0.1 Orange oil 0.1 Vetiver oil
0.02 CHG (20%) 0.25 Vitamin E 0.2 Red sandalwood extract 0.1
Resveratrol BT 0.5 White tea extract 0.5 Total Phase C 14.67
TABLE-US-00044 FGZB Spot Gel B6 Topical Gel Ingredient % w/w Phase
A (50-60) Water 12.53 Zinc lactate 0.2 Zinc gluconate 0.2 Lactic
acid 0.2 Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 2.0 Polawax .TM. NF
2.5 Cupuacu Butter 2.5 Cool to 30-40.degree. C. Phase B Sangelose
.RTM. 90 L 1% 52 Add Phase B to Phase A Chitosan 3% 10 Calendula
extract (100%/oil) 1 Total Phase A + B 83.83 Phase C Botanical
Blend Zemea .RTM. propanediol 5 Ethyl Hexyl Glycerin 1 butylene
glycol 3 Benzyl alcohol 0.5 salicylic acid 2 Bisabolol 0.1
Bakuchiol 0.5 Decanediol 0.5 Farnesol 0.3 Pomegranate oil 0.5
Rosemary oil 0.1 Orange oil 0.1 Vetiver oil 0.02 CHG (20%) 0.25
Vitamin E 0.2 Red sandalwood extract 0.1 Resveratrol BT 0.5 White
tea extract 0.5 Silicone KF6038 1.0 Total Phase C 16.17
TABLE-US-00045 FGZB Spot Gel B6-A Topical Gel Ingredient % w/w
Phase A (50-60) Water 15.53 Zinc lactate 0.2 Zinc gluconate 0.2
Lactic acid 0.2 Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 2.5 Polawax
.TM. NF 2.5 Cool to 30-40.degree. C. Phase B Sangelose .RTM. 90 L
1% 52 Add Phase B to Phase A Chitosan 3% 10 Calendula extract
(100%/oil) 1 Total Phase A + B 84.83 Phase C Botanical Blend Zemea
.RTM. propanediol 5 Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl
alcohol 0.5 salicylic acid 2 Bisabolol 0.1 Bakuchiol 0.5 Decanediol
0.5 Farnesol 0.3 Pomegranate oil 0.5 Rosemary oil 0.1 Orange oil
0.1 Vetiver oil 0.02 CHG (20%) 0.25 Vitamin E 0.2 Red sandalwood
extract 0.1 Resveratrol BT 0.5 White tea extract 0.5 Total Phase C
15.17
TABLE-US-00046 FGZB Spot Gel B6-B Topical Gel Ingredient % w/w
Phase A (50-60) Water 16.03 Zinc lactate 0.2 Zinc gluconate 0.2
Lactic acid 0.2 Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 2.5 Polawax
.TM. NF 2.5 Cool to 30-40.degree. C. Phase B Sangelose .RTM. 90 L
1% 52 Add Phase B to Phase A Chitosan 3% 10 Calendula extract
(100%/oil) 1 Total Phase A + B 85.33 Phase C Botanical Blend Zemea
.RTM. propanediol 5 Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl
alcohol 0.5 salicylic acid 2 Bisabolol 0.1 Decanediol 0.5 Farnesol
0.3 Pomegranate oil 0.5 Rosemary oil 0.1 Orange oil 0.1 Vetiver oil
0.02 CHG (20%) 0.25 Vitamin E 0.2 Red sandalwood extract 0.1
Resveratrol BT 0.5 White tea extract 0.5 Total Phase C 14.67
TABLE-US-00047 FGZB Spot Gel B7 Topical Gel Ingredient % w/w Phase
A (50-60) Water 14.53 Zinc lactate 0.2 Zinc gluconate 0.2 Lactic
acid 0.2 Glycolic acid 0.5 Aloe 100X 0.2 BTMSCB 2 Polawax .TM. NF 2
Cupuacu Butter 2 Cool to 30-40.degree. C. Phase B Sangelose .RTM.
90 L 1% 52 Add Phase B to Phase A Chitosan 3% 10 Calendula extract
(100%/oil) 1 Total Phase A + B 84.83 Phase C Botanical Blend Zemea
.RTM. propanediol 5 Ethyl Hexyl Glycerin 1 butylene glycol 3 Benzyl
alcohol 0.5 salicylic acid 2 Bisabolol 0.1 Bakuchiol 0.5 Decanediol
0.5 Farnesol 0.3 Pomegranate oil 0.5 Rosemary oil 0.1 Orange oil
0.1 Vetiver oil 0.02 CHG (20%) 0.25 Vitamin E 0.2 Red sandalwood
extract 0.1 Resveratrol BT 0.5 White tea extract 0.5 Total Phase C
15.17
TABLE-US-00048 FGZB Spot Gel SP-9 pH 4.0 Ingredient % w/w Phase A
(65-70) Water 39.65 Zinc Lactate 0.4 Zinc Gluconate 0.4 Panthenol
0.5 EDTA 0.1 hydroxyethylcellulose 2 BTMSCB 0.5 Polawax .TM. NF 0.5
Sangelose .RTM. 90L (1%) 30 Aloe 100X 1 Calendula 100% Concentrate
0.5 Total Phase A + B 75.55 NaOH (10N) 1 Phase B Botanical Blend
Benzoic acid 0.2 Thymol 0.1 Zemea .RTM. propanediol 3 Ethyl Hexyl
Glycerin 1 Benzyl alcohol 1 Salicylic acid 2 Sytenol .RTM. 0.5
Farnesol 0.5 Grapefruit seed extract 0.5 Lemon extract 0.5 Tea tree
oil (lemon scented) 1 Green Tea Extract 1 Licorice extract 0.5 Red
Sandalwood 0.15 Resveratrol 1 Frankincense oil 0.5 SDA-40B 10 Total
Phase B 23.45 100
TABLE-US-00049 FGZB Spot Gel SP-11 pH 4.0 Ingredient % w/w Phase A
(65-70) Water 36.1 Zinc Lactate 0.4 Zinc Gluconate 0.4 Panthenol
0.5 EDTA 0.1 hydroxyethylcellulose 2 BTMSCB 0.5 Polawax .TM. NF 0.5
Sangelose .RTM. 90L (1%) 30 Aloe 100X 1 Calendula 100% Concentrate
1.5 Total Phase A + B 73 NaOH (10N) 1 Phase B Botanical Blend
Benzoic acid 0.2 Thymol 0.15 Zemea .RTM. propanediol 3 Ethyl Hexyl
Glycerin 1 Benzyl alcohol 1 Salicylic acid 2 Sytenol .RTM. 0.5
Farnesol 0.5 Grapefruit seed extract 0.5 Lemon extract 0.5 Tea tree
oil (regular) 1 Tea tree oil (lemon scented) 1 Green Tea Extract 1
Licorice extract 2 Red Sandalwood 0.15 Resveratrol 1 Frankincense
oil 0.5 SDA-40B 10 Total Phase B 26 100
TABLE-US-00050 FGZB Spot Gel SP-12 pH 4.0 Ingredient % w/w Phase A
(65-70) Water 35.6 Zinc Lactate 0.4 Zinc Gluconate 0.4 Panthenol
0.5 EDTA 0.1 BTMSCB 0.5 Polawax .TM. NF 0.5 Aloe 100X 1
hydroxyethylcellulose 2.5 Sangelose .RTM. 90L (1%) 30 Calendula
100% Concentrate 1.5 Total Phase A + B 73 NaOH (10N) 1 Phase B
Botanical Blend Benzoic acid 0.2 Thymol 0.15 Zemea .RTM.
propanediol 3 Ethyl Hexyl Glycerin 1 Benzyl alcohol 1 Salicylic
acid 2 Sytenol .RTM. 0.5 Farnesol 0.5 Grapefruit seed extract 0.5
Lemon extract 0.5 Tea tree oil (unscented) 0.75 Tea tree oil (lemon
scented) 1.25 Green Tea Extract 1 Licorice extract 2 Red Sandalwood
0.15 Resveratrol 1 Frankincense oil 0.5 SDA-40B 10 Total Phase B 26
100
TABLE-US-00051 FGZB Spot Gel SP-13 pH 4.0 Ingredient % w/w Phase A
(65-70) Water 35.7 Zinc Lactate 0.4 Zinc Gluconate 0.4 Panthenol
0.5 EDTA 0.1 BTMSCB 0.5 Polawax .TM. NF 0.5 Aloe 100X 1
hydroxyethylcellulose 2.2 Sangelose .RTM. 90L (1%) 30 Calendula
100% Concentrate 1.5 Total Phase A + B 72.8 NaOH (10N) 1.2 Phase B
Botanical Blend Benzoic acid 0.20 Thymol 0.15 Zemea .RTM.
propanediol 3 Ethyl Hexyl Glycerin 1 Benzyl alcohol 1 Salicylic
acid 2 Sytenol .RTM. 0.5 Farnesol 0.5 Grapefruit seed extract 0.5
Lemon extract 0.5 Tea tree oil (unscented) 0.5 Tea tree oil (lemon
scented) 1.25 Green Tea Extract 1 Licorice extract 2 Red Sandalwood
0.15 Resveratrol 1 Frankincense oil 0.75 SDA-40B 10 Total Phase B
26 100
TABLE-US-00052 FGZB Spot Gel SP-14 pH 4.3 Ingredient % w/w Phase A
(65-70) Water 37.7 Zinc Lactate 0.4 Zinc Gluconate 0.4 Panthenol
0.5 EDTA 0.1 BTMSCB 0.5 Polawax .TM. NF 0.5 hydroxyethylcellulose
2.2 Aloe 100X 1 Sangelose .RTM. 90L (1%) 30 Calendula 100%
Concentrate 0.5 Total Phase A + B 73.8 NaOH (10N) 1.2 Phase B
Botanical Blend Benzoic acid 0.2 Thymol 0.15 Zemea .RTM.
propanediol 3 Ethyl Hexyl Glycerin 1 Benzyl alcohol 1 Salicylic
acid 2 Sytenol .RTM. 0.5 Farnesol 0.5 Grapefruit seed extract 0.5
Lemon extract 0.5 Tea tree oil (unscented) 0.5 Tea tree oil (lemon
scented) 1.25 Green Tea Extract 1 Licorice extract 1 Red Sandalwood
0.15 Resveratrol 1 Frankincense oil 0.75 SDA-40B 10 Total Phase B
25 100
TABLE-US-00053 FGZB Spot Gel SP-15 pH 4.3 Ingredient % w/w Phase A
(65-70) Water 38.7 Zinc Lactate 0.4 Zinc Gluconate 0.4 Panthenol
0.5 EDTA 0.1 BTMSCB 0.5 Polawax .TM. NF 0.5 hydroxyethylcellulose
2.2 Aloe 100X 1 Sangelose .RTM. 90L (1%) 30 Calendula 100%
Concentrate 0.5 Total Phase A + B 73.8 NaOH (10N) 1.2 Phase B
Botanical Blend Benzoic acid 0.2 Thymol 0.15 Zemea .RTM.
propanediol 3 Ethyl Hexyl Glycerin 1 Benzyl alcohol 1 Salicylic
acid 2 Farnesol 0.5 Lemon extract 0.5 Tea tree oil (unscented) 0.5
Tea tree oil (lemon scented) 1.25 Green Tea Extract 1 Licorice
extract 1 Red Sandalwood 0.15 Resveratrol 1 Frankincense oil 0.75
SDA-40B 10 Total Phase B 25 100
TABLE-US-00054 FGZB Spot Gel SP-16 pH 4.3 Ingredient % w/w Phase A
(65-70) Water 37.5 Zinc Lactate 0.4 Zinc Gluconate 0.4 Panthenol
0.5 EDTA 0.1 BTMSCB 0.5 Polawax .TM. NF 0.5 hydroxyethylcellulose
2.2 Xanthan Gum 0.5 Aloe 100X 1 Sangelose .RTM. 90L (1%) 30
Calendula 100% Concentrate 0.5 Total Phase A + B 73.8 NaOH (10N)
1.2 Phase B Botanical Blend Benzoic acid 0.2 Thymol 0.15 Zemea
.RTM. propanediol 3 Ethyl Hexyl Glycerin 1 Benzyl alcohol 1
Salicylic acid 2 Sytenol .RTM. 0.5 Farnesol 0.5 Grapefruit seed
extract 0.5 Lemon extract 0.5 Tea tree oil (unscented) 0.5 Tea tree
oil (lemon scented) 1.25 Green Tea Extract 1 Licorice extract 1 Red
Sandalwood 0.15 Resveratrol 1 Frankincense oil 0.75 SDA-40B 10
Total Phase B 25 100
TABLE-US-00055 FGZB Spot Gel BSP-1 pH 4.3 Ingredient % w/w Phase A
(65-70) Water 37.2 Zinc Lactate 0.4 Zinc Gluconate 0.4 Panthenol
0.5 EDTA 0.1 BTMSCB 0.5 Polawax .TM. NF 0.5 hydroxyethylcellulose
2.2 Aloe 100X 1 Sangelose .RTM. 90L (1%) 30 Calendula 100%
Concentrate 0.5 Total Phase A + B 73.8 NaOH (10N) 1.2 Phase B
Botanical Blend Benzoic acid 0.2 Thymol 0.15 Zemea .RTM.
propanediol 3 Ethyl Hexyl Glycerin 1 Benzyl alcohol 1 Benzoyl
Peroxide 2.5 Sytenol .RTM. 0.5 Farnesol 0.5 Grapefruit seed extract
0.5 Lemon extract 0.5 Tea tree oil (unscented) 0.5 Tea tree oil
(lemon scented) 1.25 Green Tea Extract 1 Licorice extract 1 Red
Sandalwood 0.15 Resveratrol 1 Frankincense oil 0.75 SDA-40B 10
Total Phase B 25.5 100
TABLE-US-00056 FGZB Spot Gel BSP-2 pH 4.3 Ingredient % w/w Phase A
(65-70) Water 37.7 Zinc Lactate 0.4 Zinc Gluconate 0.4 Panthenol
0.5 EDTA 0.1 BTMSCB 0.5 Polawax .TM. NF 0.5 hydroxyethylcellulose
2.2 Aloe 100X 1 Sangelose .RTM. 90L (1%) 30 Calendula 100%
Concentrate 0.5 Total Phase A + B 73.8 NaOH (10N) 1.2 Phase B
Botanical Blend Benzoic acid 0.2 Thymol 0.15 Zemea .RTM.
propanediol 3 Ethyl Hexyl Glycerin 1 Benzyl alcohol 1 Salicylic
Acid 1 Benzoyl Peroxide 1 Sytenol .RTM. 0.5 Farnesol 0.5 Grapefruit
seed extract 0.5 Lemon extract 0.5 Tea tree oil (unscented) 0.5 Tea
tree oil (lemon scented) 1.25 Green Tea Extract 1 Licorice extract
1 Red Sandalwood 0.15 Resveratrol 1 Frankincense oil 0.75 SDA-40B
10 Total Phase B 25 100
TABLE-US-00057 FGZB Scar Removal Serum Acne Scar Removal Serum
(SR-6) Ingredient % w/w Aloe gel 60 Lemon extract 5 Almond oil 10
Glycerin 6.3 Panthenol 0.5 Zemea .RTM. propanediol 5 Tween .RTM. 20
1 Helichrysum oil 0.5 Calendula oil 0.5 Frankincense oil 0.5
Broccoli seed oil 0.5 Raspberry seed oil 0.3 Pomegranate seed oil
0.4 Tomato Seed Oil 5 Vitamin E 2.5 Neroli oil 0.5 Geranium oil 0.5
Lavender oil 0.5 Cedarwood oil 0.5 Total 100
TABLE-US-00058 Acne Scar Removal Serum (SR-6B) Ingredient % w/w
BTMSCB 0.1 Polawax .TM. 0.1 Zinc gluconate 0.1 Aloe gel 49.2
Sangelose .RTM. (1%) 10 Lemon extract 5 Almond oil 10 Glycerin 6.3
Panthenol 0.5 Zemea .RTM. propanediol 5 Tween .RTM. 20 1
Helichrysum oil 0.5 Calendula oil 0.5 Frankincense oil 0.5 Broccoli
seed oil 0.5 Raspberry seed oil 0.3 Pomegranate seed oil 0.4 Tomato
Seed Oil 5 Vitamin E 2.5 Neroli oil 0.5 Geranium oil 0.5 Lavender
oil 0.5 Cedarwood oil 0.5 Salicylic Acid 0.5 Total 100
TABLE-US-00059 Acne Scar Removal Serum (SR-7) Ingredient % w/w
Almond oil 10 Sunflower oil 8 BTMSCB 0.1 Polawax .TM. 0.1 Zinc
gluconate 0.1 Aloe gel 50 Sangelose .RTM. (1%) 10 Lemon extract 5
Zemea .RTM. propanediol 4.5 Panthenol 0.5 Tween .RTM. 20 1
Helichrysum oil 0.5 Calendula oil 0.5 Frankincense oil 0.5 Broccoli
seed oil 0.5 Raspberry seed oil 0.3 Pomegranate seed oil 0.4 Tomato
Seed Oil 5 Vitamin E 1 Neroli oil 0.5 Myrrh 0.5 Cedarwood oil 0.5
Salicylic Acid 0.5 Total 100
TABLE-US-00060 Acne Scar Removal Serum (SR-8) Ingredient % w/w
Almond oil 8 Coconut oil 5 BTMSCB 0.1 Polawax .TM. 0.1 Zinc
gluconate 0.2 Aloe gel 50 Sangelose .RTM. (1%) 10 Lemon extract 5
Sunflower seed oil 5 Honey 5 Helichrysum oil 0.5 Calendula oil 0.5
Frankincense oil 0.5 Tea tree oil 0.5 Panthenol 0.5 Pomegranate
seed oil 0.3 Tomato Seed Oil 5 Vitamin E 1 Sorbitan Oleate (Tween
.RTM. 20) 1 Myrrh 0.3 Cedarwood oil 0.5 Salicylic acid 0.5 Neroli
0.25 Geranium 0.25 Total 100
TABLE-US-00061 Acne Scar Removal Serum (SR-8B) Ingredient % w/w
Almond oil 7.7 Coconut oil 5 BTMSCB 0.1 Polawax .TM. 0.1 Zinc
gluconate 0.2 Aloe gel 50 Xanthan gum 0.3 Sangelose .RTM. (1%) 10
Lemon extract 5 Sunflower seed oil 5 Honey 5 Helichrysum oil 0.5
Calendula oil 0.5 Frankincense oil 0.5 Tea tree oil 0.5 Panthenol
0.5 Pomegranate seed oil 0.3 Tomato Seed Oil 5 Vitamin E 1 Sorbitan
Oleate (Tween .RTM. 20) 1 Myrrh 0.3 Cedarwood oil 0.5 Salicylic
acid 0.5 Neroli 0.25 Geranium 0.25 Total 100
TABLE-US-00062 FGZB Exfoliant Wipe Solution Exfoliant Wipe Solution
- EW3 Ingredient % w/w Aloe gel (Carbopol .RTM.) 50 Water 16.8 Zinc
gluconate 0.2 Panthenol 0.5 Apple cider Vinegar 10 Rosewater 5
Lemon extract 5 Tea tree oil 0.5 Tween .RTM. 20 1 Zemea .RTM.
propanediol 10 Salicylic acid 0.5 Witch hazel Distillate 1 Total
100
TABLE-US-00063 Exfoliant Wipe Solution - EW4 Ingredient % w/w Aloe
gel (Carbopol .RTM.) 40 Water 16.8 Zinc gluconate 0.2 Panthenol 0.5
Apple cider Vinegar 10 Rosewater 5 Lemon extract 5 Tea tree oil 0.5
Tween .RTM. 20 1 Salicylic acid 0.5 Glycerin 10 Sangelose .RTM.
(1%) 10 BTMSCB 0.5 Polawax .TM. 0.5 Witch hazel distillate 1 Total
100
TABLE-US-00064 Exfoliant Wipe Solution - EW5 Ingredient % w/w Water
16.1 Incroquat .TM. 0.1 Polawax .TM. 0.1 Aloe gel (Carbopol .RTM.)
40 Sangelose .RTM. 10 Zinc gluconate 0.2 Panthenol 0.5 Apple cider
Vinegar 10 Rosewater 5 Lemon extract 5 Tween .RTM. 20 1 Zemea .RTM.
propanediol 10 Salicylic Acid 0.5 Witch hazel Distillate 1 Tea tree
oil 0.5 Total 100
TABLE-US-00065 Exfoliant Wipe Solution - EW6 Ingredient % w/w Water
26.8 Salicylic acid 0.5 Honey 5 Apple cider vinegar 10 Lemon
extract 0.5 Rosewater 5 Tea tree oil (lemon scented) 0.3 Coconut
oil 5 Panthenol 0.5 Aloe gel 30 Zinc gluconate 0.2 Panthenol 0.5
Sesame seed oil 5 Vitamin E 0.5 Sangelose .RTM. (1%) 10 BTMSCB 0.1
Polawax .TM. 0.1 Total 100
TABLE-US-00066 Exfoliant Wipe Solution - EW7 Ingredient % w/w Aloe
gel (Carbopol .RTM.) 40 Water 14.8 hydroxyethylcellulose 0.5
Panthenol 0.5 Zinc gluconate 0.2 Apple cider Vinegar 10 Rosewater 5
Lemon extract 5 Tea tree oil 0.5 Tween .RTM. 20 1 Salicylic acid
0.5 Glycerin 10 Sangelose .RTM. (1%) 10 BTMSCB 0.5 Polawax .TM. 0.5
Witch hazel distillate 1 Total 100
TABLE-US-00067 Exfoliant Wipe Solution - EW7B Ingredient % w/w Aloe
gel (Carbopol .RTM.) 40 Water 14.5 hydroxyethylcellulose 0.5
Panthenol 0.5 Xanthan gum 0.3 Zinc gluconate 0.2 Apple cider
Vinegar 10 Rosewater 5 Lemon extract 5 Tea tree oil 0.5 Tween .RTM.
20 1 Salicylic acid 0.5 Glycerin 10 Sangelose .RTM. (1%) 10 BTMSCB
0.5 Polawax .TM. 0.5 Witch hazel distillate 1 Total 100
TABLE-US-00068 Acute Scar Removal Cream AS-1 Ingredient % w/w
BTMSCB 0.5 Polawax .TM. 0.5 Sangelose .RTM. (1%) 10 Salicylic acid
0.5 Panthenol 0.5 Zinc gluconate 0.2 Helichrysum oil 0.5
Frankincense oil 0.5 Rose hip oil 0.3 Neroli oil 0.25 Geranium oil
0.25 Almond oil 10.5 Jojoba oil 8 Apple cider vinegar 5 Aloe gel 50
Onion extract 1 Emu oil 1 Tea tree oil 0.5 Honey 10 Total 100
TABLE-US-00069 AS-1B Ingredient % w/w BTMSCB 0.5 Polawax .TM. 0.5
Sangelose .RTM. (1%) 10 Xanthan Gum 0.3 Salicylic acid 0.5
Panthenol 0.5 Zinc gluconate 0.2 Helichrysum oil 0.5 Frankincense
oil 0.5 Rose hip oil 0.3 Neroli oil 0.25 Geranium oil 0.25 Almond
oil 10.5 Jojoba oil 7.7 Apple cider vinegar 5 Aloe gel 50 Onion
extract 1 Emu oil 1 Tea tree oil 0.5 Honey 10 Total 100
Example 4
Comparison of Antibacterial Efficacy of FGZB Spot Gel and Other
Spot Gel Formulations Containing Zinc Salts, Botanicals and
Salicylic Acid Acne Cream 1 and 2
TABLE-US-00070 [0078] Acne Cream 1 Ingredients % WT Salicylic acid
(active) 2% Base ingredients WATER (AQUA) Q.S to 100 ALCOHOL
DENATURED. 10 PROPYLENE GLYCOL 1 HYDROXYETHYLCELLULOSE 2 DIMETHYL
ISOSORBIDE 0.1 ZINC GLUCONATE 0.2 ZINC LACTATE 0.2 PANTHENOL 0.5
PEG-8 (Polyethylene glycol) 1 ALOE BARBADENSIS LEAF EXTRACT 0.01
CAMELLIA OLEIFERA LEAF EXTRACT 0.001 BUTYLENE GLYCOL 1 COCOS
NUCIFERA (COCONUT) WATER 0.99 WITHANIA SOMNIFERA FLOWER EXTRACT
0.99 PICHIA/RESVERATROL FERMENT EXTRACT 0.5 PHOSPHOLIPIDS 0.0001 to
0.5 RETINYL PALMITATE 0.1 ASCORBYL PALMITATE 0.1 TOCOPHERYL ACETATE
0.1 GLYCOLIC ACID 0.5 GLYCERIN 1 ETHYLHEXYLGLYCERIN 0.2 to 3
PHENOXYETHANOL 0.99 SODIUM HYDROXIDE 0.5 100%
TABLE-US-00071 Acne Cream 2 Ingredients % WT Deionized Water Q.S.
to 100 Hydroxyethyl cellulose 1 Zinc Lactate 0.2 Zinc Gluconate 0.2
Glycolic Acid (70%) 1.6 Glycerin 1 1,3 Butylene Glycol 6 Ritapan
.RTM. D 0.5 Deionized Water 10 KOH 1.5 SD Alcohol 12 Dimethyl
Isosorbide 5 Symcalmin .RTM. 1 Ethyl Hexyl Glycerin 0.3 Ritabate
.RTM. 20 4 Farnesol 0.3 Phenoxyethanol 0.7 Vitamin E Acetate 0.01
Vitamin A Palmitate 0.01 Vitamin C (BVOSC) 0.01 Chlorhexidine
Gluconate 0.2 Benzalkonium chloride 0.12 White Tea Extract (BC) 1
Resveratrol (BC Research) 1 AFG 1224 Jaffa Orange 0.5 100
TABLE-US-00072 FGZB B-2 Topical Gel Ingredient % w/w Deionized
Water Q.S. to 100 Zinc gluconate 0.2 Zinc lactate 0.2 Aloe powder
0.2 Hydroxy propyl methyl cellulose (Methocel .TM.) 0.5 Glycolic
acid 0.2 Lactic acid 0.2 BTMSCB emulsifier 2.5 Polawax .TM.
emulsifier 3 HPMCSE polymer 0.5 Chitosan polymer 0.15 Calendula
extract 0.2 Alcohol denatured 10 1,3 propanediol 2 Caprylil capril
triglyceride 2 Ethyl hexyl glycerin 1 Decanediol 0.5 Bisabolol 0.1
Pomegranate oil 0.5 Rosemary oil 0.1 Thymol 0.1 Menthol 0.1 Orange
oil 0.2 Vetiver oil 0.02 Resveratrol 0.5 Red sandalwood extract 0.1
Chlorhexidine gluconate QS to 100
TABLE-US-00073 TABLE 3 Table 3: Antibacterial efficacy of FGZB-B2
spot cream against S. aureus: comparison with other Acne cream
products containing, salicylic acid Product Zone of inhibition (mm)
Acne cream 1 15 Acne cream 2 12 FGZB -B2 18
[0079] Conclusion: FGZB-1 Shows larger zone of inhibition against
S. aureus which is also responsible for Acne pimples.
TABLE-US-00074 TABLE 4 Table 4: Efficacy of FG ZB-B2 on 2 subjects
after 7 to10 days of treatment Volunteer 1 Volunteer 2 Percent
reduction in size of the pimples 50 80 Percent reduction in pimples
50 70 Percent reduction in redness 60 100
[0080] Results showed 50 to 100 percent reduction in acne symptoms
after only 7 to 10 days of treatment. Advantageously, no itching
and/or burning sensation was reported in either of the
volunteers.
[0081] Formulations containing salicylic acid have been shown to
improve acne affected skin in 4-6 weeks. Our preliminary evaluation
indicates that FGZB shows improvement in acne affected skin in 7-10
days.
[0082] Although the present invention has been described in
relation to embodiments thereof, these embodiments and examples are
merely exemplary and not intended to be limiting. Many other
variations and modifications and other uses will become apparent to
those skilled in the art. The present invention should, therefore,
not be limited by the specific disclosure herein, and can be
embodied in other forms not explicitly described here, without
departing from the spirit thereof.
* * * * *