U.S. patent application number 17/362707 was filed with the patent office on 2021-10-21 for composition for treating vitiligo.
The applicant listed for this patent is KUWAIT UNIVERSITY. Invention is credited to MOHAMMAD ABDULRAHMAN ALI ALANSARI.
Application Number | 20210322504 17/362707 |
Document ID | / |
Family ID | 1000005684759 |
Filed Date | 2021-10-21 |
United States Patent
Application |
20210322504 |
Kind Code |
A1 |
ALANSARI; MOHAMMAD ABDULRAHMAN
ALI |
October 21, 2021 |
COMPOSITION FOR TREATING VITILIGO
Abstract
A first embodiment of a composition for treating vitiligo
includes Cassia tora powder, Saussurea lappa root powder, Punica
granatum L. (pomegranate) peels powder, and Psoralea corylifolia
black seed powder. A second embodiment of a composition for
treating vitiligo can include Cassia tora powder, Saussurea lappa
root powder, Punica granatum L. (pomegranate) peels powder,
Berberries (or Berberis) vulgaris root powder, red clay (with trace
copper), and Ptycholis verlicillata root powder. Topical
administration of the first composition followed by UV radiation
exposure can facilitate inducing melanogenesis as well as
generating ROS. Topical administration of the second composition
following the UV radiation exposure can scavenge the ROS generated
by the first composition.
Inventors: |
ALANSARI; MOHAMMAD ABDULRAHMAN
ALI; (Adailiyya, KW) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
KUWAIT UNIVERSITY |
SAFAT |
|
KW |
|
|
Family ID: |
1000005684759 |
Appl. No.: |
17/362707 |
Filed: |
June 29, 2021 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
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16134092 |
Sep 18, 2018 |
|
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17362707 |
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Current U.S.
Class: |
1/1 |
Current CPC
Class: |
A61K 36/29 20130101;
A61K 9/0014 20130101; A61K 36/28 20130101; A61P 17/00 20180101;
A61K 36/23 20130101; A61N 5/062 20130101; A61N 2005/0661 20130101;
A61K 36/185 20130101; A61K 36/482 20130101; A61N 5/0616 20130101;
A61K 36/487 20130101; G01N 2800/207 20130101; A61K 33/06
20130101 |
International
Class: |
A61K 36/487 20060101
A61K036/487; A61P 17/00 20060101 A61P017/00; A61K 9/00 20060101
A61K009/00; A61K 36/185 20060101 A61K036/185; A61K 36/23 20060101
A61K036/23; A61K 36/28 20060101 A61K036/28; A61K 36/29 20060101
A61K036/29; A61K 36/482 20060101 A61K036/482; A61N 5/06 20060101
A61N005/06 |
Claims
1-7. (canceled)
8. A two-part composition for treating vitiligo, comprising: a
first part, the first part consisting of one part Psoralea
corylifolia black seed powder, five parts Cassia tora powder, three
parts Saussurea lappa root powder, and ten parts Punica granatum L.
(pomegranate) peels powder; and a second part, the second part
distinct from the first part and consisting of two parts Berberries
vulgaris root powder, three parts Cassia tora powder, one part red
clay (with trace copper), two parts Saussurea lappa root extract,
two parts Ptychotis verticillata root powder, and two parts Punica
granatum L. peels powder.
9-11. (canceled)
Description
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation of application Ser. No.
16/134,092, filed Sep. 18, 2018, now pending.
BACKGROUND
1. Field
[0002] The disclosure of the present patent application relates to
topical medicines and protocols, and particularly to a vitiligo
treatment medicine and protocol based on separate pulse
administration of vitiligo treatment compositions in addition to
phototherapy.
2. Description of the Related Art
[0003] Vitiligo is a multigene and multifactorial disorder that
results in the depigmentation of the skin. Current treatments for
vitiligo include UV (ultra-violent) radiation therapy. UV radiation
induces melanin production in the skin through melanogenesis.
Normal melanogenesis occurs in melanocytes, where tyrosine is
converted to melanin by the enzyme tyrosinase and copper co-factor.
UV radiation also produces reactive oxygen species (ROS).
Typically, ROS is scavenged by the body's natural antioxidants.
Patients suffering from vitiligo, however, have decreased natural
antioxidant activity and increased reactive oxygen species (ROS).
Increased ROS and low levels of self-antioxidants can cause
oxidative damage to melanocytes. Excessive ROS can cause changes in
lipids and protein structure in a way that triggers antibody
production against melanocytes. As such, while conventional UV
radiation therapies can generate melanin, the excessive ROS that
can also be generated can damage pigment cells.
[0004] Phototherapy can also generate peroxynitrite. Peroxynitrite
can attack the phenol ring of amino acid tyrosine, the building
block of melanin. Accordingly, peroxynitrite can inhibit or prevent
melanin production.
[0005] Thus, a composition and method for treating vitiligo solving
the aforementioned problems is desired.
SUMMARY
[0006] A first embodiment of a composition for treating vitiligo
includes Cassia tora powder. Saussurea lappa root powder, Punica
granatum L. (pomegranate) peels powder, and Psoralea corylifolia
black seed powder. The first embodiment can include one part
Psoralea corylifolia black seed powder, five parts Cassia tora
powder, three parts Saussurea lappa root powder, and ten parts
Punica granatum L (pomegranate) peels powder.
[0007] A second embodiment of a composition for treating vitiligo
can include Cassia fora powder, Saussurea lappa root powder, Punica
granatum L. (pomegranate) peels powder, Berberries (or Berberis)
vulgaris root powder, red clay (with trace copper), and Ptycholis
verlicillata root powder. The second embodiment can include two
parts Berberries (or Berberis) vulgaris root powder; three parts
Cassia tora powder; one part red clay (with trace copper); two
parts Saussurea lappa root extract; two parts Ptycholis
verticillata root powder; and two parts Punica granatum L peels
powder.
[0008] A method of treating vitiligo can include applying the first
embodiment of the composition to the patient's skin, exposing the
skin to a UV radiation source, e.g., sunlight, after application of
the first embodiment of the composition, washing the first
embodiment of the composition from the skin, applying the second
embodiment of the composition to the skin, and exposing the skin to
the UV radiation again after application of the second embodiment
of the composition. The method can be repeated until desired
results are achieved. The first embodiment of the composition can
be allowed to remain on the skin for a short period of time, for
example about 5 minutes, prior to exposing the treated skin to UV
radiation. Similarly, the second embodiment of the composition can
be allowed to remain on the skin for a short period of time, for
example about 5 minutes, prior to exposing the treated skin to UV
radiation. The exposure to sunlight or UV radiation can range from
about 30 seconds to about 15 minutes, depending upon the
sensitivity of the skin. The first composition can facilitate
inducing melanogenesis as well as generating ROS. The second
composition can scavenge the ROS generated by the first
composition.
[0009] These and other features of the present disclosure will
become readily apparent upon further review of the following
specification and drawings.
BRIEF DESCRIPTION OF THE DRAWING
[0010] The sole FIGURE is a block diagram of the vitiligo treatment
protocol.
[0011] Similar reference characters denote corresponding features
consistently throughout the attached drawing.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0012] A method for treating vitiligo can include topically
administering a first embodiment of a vitiligo treatment
composition ("first composition") to the affected skin of a patient
suffering from vitiligo, exposing the skin treated with the first
composition to UV radiation, washing the first composition off of
the treated skin, administering a second embodiment of a vitiligo
treatment composition ("second composition") to the affected skin
of the patient, and exposing the skin treated with the second
composition to UV radiation. The first composition and the second
composition both include Cassia tora powder, Saussurea lappa root
powder, and Punica granatum L. (pomegranate) peels powder. The
first composition further includes Psoralea corylifolia black seed
powder. The second composition further includes Berberries (or
Berberis) vulgaris root powder, red clay (with trace copper), and
Ptychotis verticillata root powder. In an embodiment, the first
composition includes one part Psoralea corylifolia black seed
powder, five parts Cassia tora powder, three parts Saussurea lappa
root powder, and ten parts Punica granatum L (pomegranate) peels
powder. In an embodiment, the second composition includes two parts
Berberries (or Berberis) vulgaris root powder, three parts Cassia
tora powder, one part red clay (with trace copper), two parts
Saussurea lappa root extract, two parts Ptychotis verticillata root
powder, and two parts Punica granatum L. peels powder.
[0013] The first embodiment of the composition can be allowed to
remain on the skin for a short period of time, for example about 5
minutes, prior to exposing the treated skin to UV radiation. The
second embodiment of the composition can be allowed to remain on
the skin for a short period of time, for example about 5 minutes,
prior to exposing the treated skin to UV radiation. The exposure to
sunlight or UV radiation can range from about 30 seconds to about
10 minutes, depending upon the sensitivity of the skin.
[0014] The first composition can facilitate inducing melanogenesis
as well as generating ROS. The second composition can scavenge the
ROS generated by the first composition. Psoralea extract is a known
photosynthesizer. Saussurea lappa has natural immunomodulatory
effects and can, thereby, prevent an immune response in the event
of excessive ROS production. Cassia tora can serve as a
peroxinitrite scavenger to protect the phenol ring of tyrosine from
oxidative damage. Red clay with copper co-factor can also
facilitate melanogenesis.
[0015] It is believed that the pulse application of the first
composition, which includes photosensitive compounds, followed by a
very short duration of UV radiation exposure, and subsequent
application of the second composition, which includes antioxidants,
can trigger melanogenesis while avoiding excessive/cascade of ROS
reactions.
[0016] The first composition can be prepared by mixing one part
Psoralea corylifolia black seed powder, five parts Cassia tora
powder, three parts Saussurea lappa root powder, and ten parts
Punica granatum L (pomegranate) peels powder to provide a first
powder mixture, and adding water to the first powder mixture, e.g.,
in a 1:4 volume ratio, to provide the first composition. The second
composition can be prepared by mixing two parts Berberries (or
Berberis) vulgaris root powder, three parts Cassia tora powder, one
part red clay (with trace copper), two parts Saussurea lappa root
extract, two parts Ptycholis verticillata root powder, and two
parts Punica granatum L. peels powder to provide a second powder
mixture, and adding water to the second powder mixture, e.g., in a
1:4 volume ratio, to provide the second composition.
[0017] As shown in the sole FIGURE, an exemplary treatment protocol
or method of vitiligo treatment 100 according to the present
teachings includes a first step 102 of applying the first
composition to the skin, waiting about 5 minutes 104, exposing the
skin to sunlight (or another UV light source) in step 106, washing
the first composition from the skin 108, applying the second
composition to the skin 110, waiting about 5 minutes 112, exposing
the skin to sunlight 114, and washing the second composition from
the skin 116. The initial exposure time in step 106 and step 112
can be about 30 seconds, but can be increased by 30 seconds every 3
days to a maximum of 15 minutes, if there is no skin redness or
phototoxicity. As shown by the line 118, after step 116, the
treatment method 100 returns to the first step 102 to be repeated
as necessary.
[0018] A composition for treating vitiligo, according to a first
embodiment, can include Psoralea corylifolia black seed powder,
Cassia tora powder, Saussurea lappa root powder, and Punica
granatum L (pomegranate) peels powder. For example, the composition
can include one part Psoralea corylifolia black seed powder, five
parts Cassia tora powder, three parts Saussurea lappa root powder,
and ten parts Punica granatum L (pomegranate) peels powder.
[0019] A composition for treating vitiligo, according to a second
embodiment can include Berberries (or Berberis) vulgaris root
powder, Cassia tora powder, red clay (with trace copper); Saussurea
lappa root extract, Ptychotis verticillata root powder, and Punica
granatum L peels powder. For example, the composition can include
two parts Berberries (or Berberis) vulgaris root powder, three
parts Cassia tora powder, one part red clay (with trace copper),
two parts Saussurea lappa root extract, two parts Ptychotis
verticillata root powder, and two parts Punica granatum L. peels
powder.
[0020] The present teachings are illustrated by the following
examples.
Example 1
[0021] A 32 year old male patient with non-segmental vitiligo (NSV)
was treated according to the protocol set forth in the sole FIGURE.
The treatment was administered to the skin of the patient in the
hip, neck, arm, hand and knee areas. The treatment was provided
from July 2016 to December 2017. In October of 2016, the neck area
showed repigmentation and by 19 Jan. 2017, the neck area was almost
completely cured. The right hand of the patient showed 10-15%
repigmentation by October 2016. Hands are generally more difficult
to treat for vitiligo. The left arm area showed 70-80%
repigmentation by October 2016 and by January 2017 the left arm
area had 95% repigmentation. The hip area of the patient showed
improvement within two weeks and more than 60-70% repigmentation
between Mar. 8, 2017 and Dec. 6, 2017. The knee of the patient
showed very good repigmentation at week 9 and week 15 of the study,
particularly around the hair follicles.
Example 2
[0022] A 35 year old male patient with segmental vitiligo (SV) on
his lips was treated according to the protocol set forth in the
sole FIGURE. The lips are a very difficult area to treat vitiligo
and most treatment methods are ineffective. Within 10 weeks the SV
was almost completely cured.
Example 3
[0023] A 32 year old female patient with progressive NSV on her
left arm was treated according to the protocol set forth in the
sole FIGURE. Within one month, some repigmentation had
occurred.
Example 4
[0024] A 20 year old female patient with progressive NSV just
starting on her shoulder, left eyelid and left wrist was treated
according to the protocol set forth in the sole FIGURE. The eyelids
are also a very difficult area to treat vitiligo and most treatment
methods are ineffective. The treatment achieved good results.
Example 5
[0025] A 26 year old male patient with SV around the mouth area was
treated according to the protocol set forth in the sole FIGURE. In
addition to treating the vitiligo, generally improved skin health
was observed including a reduction of acne on the patient's face.
Prior, conventional UV treatment had not been successful.
Example 6
[0026] A 38 year old female patient with NSV on her legs was
treated according to the protocol set forth in the sole FIGURE.
This patient was a smoker. Generally, smokers are less responsive
to NSV treatment. After three months of treatment, improvement was
limited, but after five months, repigmentation was visible and the
area of the vitiligo was reduced.
Example 7
[0027] A 10 year old female patient with progressive NSV on her
eyelids was treated according to the protocol set forth in the sole
FIGURE. After treatment, complete repigmentation of the eyelids was
observed.
Example 8
[0028] A 37-year old female patient with progressive NSV on her
forehead was treated according to the protocol set forth in the
sole FIGURE. Repigmentation of the forehead was observed within 20
days of treatment. Within 30 days, almost complete repigmentation
of the forehead was observed. General skin health improvement was
also observed including a decrease in acne.
[0029] It is to be understood that a method for treating vitiligo
is not limited to the specific embodiments described above, but
encompasses any and all embodiments within the scope of the generic
language of the following claims enabled by the embodiments
described herein, or otherwise shown in the drawings or described
above in terms sufficient to enable one of ordinary skill in the
art to make and use the claimed subject matter.
* * * * *