U.S. patent application number 17/238773 was filed with the patent office on 2021-10-21 for methods and compositions for increasing the suppressive function of regulatory t-cells (tregs). The applicant listed for this patent is New York University, Regents of the University of Minnesota. Invention is credited to Bruce R. Blazar, Michael Dustin, Keli Hippen, Sudha Kumari, Cameron McDonald-Hyman, James Muller, Tom Neubert.
Application Number | 20210322455 17/238773 |
Document ID | / |
Family ID | 1000005695889 |
Filed Date | 2021-10-21 |
United States Patent Application | 20210322455 |
Kind Code | A1 |
Blazar; Bruce R. ; et al. | October 21, 2021 |
Methods and compositions for increasing the suppressive function of regulatory T-cells (Tregs) are provided.
Inventors: | Blazar; Bruce R.; (Golden Valley, MN) ; McDonald-Hyman; Cameron; (St. Paul, MN) ; Dustin; Michael; (New York, NY) ; Kumari; Sudha; (New York, NY) ; Neubert; Tom; (New York, NY) ; Muller; James; (New York, NY) ; Hippen; Keli; (Minneapolis, MN) | ||||||||||
Applicant: |
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Family ID: | 1000005695889 | ||||||||||
Appl. No.: | 17/238773 | ||||||||||
Filed: | April 23, 2021 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
15757516 | Mar 5, 2018 | 10993959 | ||
PCT/US2016/050215 | Sep 2, 2016 | |||
17238773 | ||||
62214680 | Sep 4, 2015 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | C12N 15/1137 20130101; A61P 35/00 20180101; C12N 15/1138 20130101; C12N 5/0637 20130101; C12N 2310/14 20130101; A61K 31/7105 20130101; A61K 35/17 20130101 |
International Class: | A61K 31/7105 20060101 A61K031/7105; C12N 15/113 20060101 C12N015/113; A61P 35/00 20060101 A61P035/00; A61K 35/17 20060101 A61K035/17; C12N 5/0783 20060101 C12N005/0783 |
Sequence CWU 1
1
1719659DNAHomo sapiens 1tttgtgttac ataattgcct ttcatttgaa ctcattaatc
aaattggggt ttttaagcaa 60cacctaatta attctttaac tggctcatat tataccttta
atgacttcca ccagggtaaa 120aaccactgat cactgagttc tattttgaaa
ctacggacgt cgagtttcct ctttcaccca 180gaattttcag atcttgttta
aaaagttggg tgtggtttca tggggggagg gggaagagcg 240agaggagacc
agagggacgg gggcggggac tctgcaagaa aaaccttccc ggtgcaatcg
300tgatctggga ggcccacgta tggcgcctct ccaaaggctg cagaagtttc
ttgctaacaa 360aaagtccgca cattcgagca aagacaggct ttagcgagtt
attaaaaact taggggcgct 420cttgtccccc acagggcccg accgcacaca
gcaaggcgat ggcccagctg taagttggta 480gcactgagaa ctagcagcgc
gcgcggagcc cgctgagact tgaatcaatc tggtctaacg 540gtttccccta
aaccgctagg agccctcaat cggcgggaca gcagggcgcg gtgagtcacc
600gccggtgact aagcgacccc acccctctcc ctcgggcttt cctctgccac
cgccgtctcg 660caactcccgc cgtccgaagc tggactgagc ccgttaggtc
cctcgacaga acctcccctc 720cccccaacat ctctccgcca aggcaagtcg
atggacagag gcgcgggccg gagcagcccc 780cctttccaag cgggcggcgc
gcgaggctgc ggcgaggcct gagccctgcg ttcctgcgct 840gtgcgcgccc
ccaccccgcg ttccaatctc aggcgctctt tgtttctttc tccgcgactt
900cagatctgag ggattcctta ctctttcctc ttcccgctcc tttgcccgcg
ggtctccccg 960cctgaccgca gccccgagac cgccgcgcac ctcctcccac
gcccctttgg cgtggtgcca 1020ccggacccct ctggttcagt cccaggcgga
cccccccctc accgcgcgac cccgcctttt 1080tcagcacccc agggtgagcc
cagctcagac tatcatccgg aaagccccca aaagtcccag 1140cccagcgctg
aagtaacggg accatgccca gtcccaggcc ccggagcagg aaggctcgag
1200ggcgccccca ccccacccgc ccaccctccc cgcttctcgc taggtcccta
ttggctggcg 1260cgctccgcgg ctgggatggc agtgggaggg gaccctcttt
cctaacgggg ttataaaaac 1320agcgccctcg gcggggtcca gtcctctgcc
actctcgctc cgaggtcccc gcgccagaga 1380cgcagccgcg ctcccaccac
ccacacccac cgcgccctcg ttcgcctctt ctccgggagc 1440cagtccgcgc
caccgccgcc gcccaggcca tcgccaccct ccgcagccat gtccaccagg
1500tccgtgtcct cgtcctccta ccgcaggatg ttcggcggcc cgggcaccgc
gagccggccg 1560agctccagcc ggagctacgt gactacgtcc acccgcacct
acagcctggg cagcgcgctg 1620cgccccagca ccagccgcag cctctacgcc
tcgtccccgg gcggcgtgta tgccacgcgc 1680tcctctgccg tgcgcctgcg
gagcagcgtg cccggggtgc ggctcctgca ggactcggtg 1740gacttctcgc
tggccgacgc catcaacacc gagttcaaga acacccgcac caacgagaag
1800gtggagctgc aggagctgaa tgaccgcttc gccaactaca tcgacaaggt
gcgcttcctg 1860gagcagcaga ataagatcct gctggccgag ctcgagcagc
tcaagggcca aggcaagtcg 1920cgcctggggg acctctacga ggaggagatg
cgggagctgc gccggcaggt ggaccagcta 1980accaacgaca aagcccgcgt
cgaggtggag cgcgacaacc tggccgagga catcatgcgc 2040ctccgggaga
agtaaggctg cgcccatgca agtagctggg cctcgggagg gggctggagg
2100gagaggggaa cgcccccccg gcccccgcga gagctgccac gcccttgggg
atgtggccgg 2160ggggaggcct gccagggaga cagcggagag cggggctgtg
gctgtggtgg cgcagccccg 2220cccagaaccc agaccttgca gttcgcattt
cctcctctgt ccccacacat tgcccaagga 2280cgctccgttt caagttacag
atttcttaaa actaccactt tgtgtgcagt tgaaggccct 2340tgggcacaat
gagagccagt cctccaaact ttcagaaagt ttcctgcccc ttctggcagg
2400ctgccaatca ccgggcggga gaaggaagga ggggaaggcg gtggagggag
cgagacaaag 2460ggatggtccc tcgggggcgg ggatggcggg gctgtcctgt
aggtctgtgc ggccaccgtg 2520attgcccctc tgcgcggtgc ccgaagtccc
gctgaaacct gccgagggca gcaggtctga 2580aagctgcagg cgctagttgc
gcggaggtgg cgcagctgct ctggaggcgc agagcgaata 2640cgtggtgttt
gggtgtggcc gccccgcccc tggcggtttc ctcgttcccc tttggttaat
2700gcgcaactgt ttcagattgc aggaggagat gcttcagaga gaggaagccg
aaaacaccct 2760gcaatctttc agacaggttt gtagactctc ttcccactcg
cagccgcctg accccaccca 2820acacaaccca cgagcaattc taaaagttgc
ttaactcacg tctaaaaagt gcaaaacttc 2880agggctgcgc gtaaagccct
ctagtggcgg gaagaccaca ggttggagct tctcatgatt 2940agaaaaatat
taataaaacc ccttgagcga tttttttttt ttttttgaga cggagtctta
3000ctctgtcgcc caggctggag tgcagtggcg agatcttggc tcactgcatc
ctccgcctcc 3060cgggttcaag cgatccttga atgatttcta agcagttcct
tgggacataa agaaaaatct 3120tttaactttt tactttgttt cccaaatgtt
gcacagtttt gcaacacatt gaccttctgg 3180tttcgaacgg ttacaatttt
agattgtggt ttgccaaagt caagttgctt aatttttaca 3240aggccacaaa
aagcgcaatt atgccctgca gtttaaaatg gaaaacgtgt tggaagataa
3300gaaaacttag tttccaactg gaatggagcc agcaagtttc ttttcttctt
tgcaaattct 3360attgtgtcat taaagttcga tggaagtatc actatgcaca
actattttgt gatctaataa 3420gggtgaaaag gagccatctg tccccttggc
taaggggtat taatggtttc tatgggcttc 3480actatggaat gtagatacag
acattctggc aaatgtggtg gctctggaca gaaataatag 3540gagtctttgt
attcccaggg aagctttgca acaggctaca ttcttactga atatgtaatg
3600atgtaagcac ggttctaatt ggacacaagt atttgctaac atccgttatc
taatatctgg 3660cccagacttg agaagtaggt aatgtaaaaa gtttttaaag
ctacaagcat acctcacatt 3720ttaaaagtcc tttcttgatt gggttcttgt
gttctttagc actcttgcca taaaaaataa 3780taacagtaat aaacccaagg
ctgaaaaact gaattttaac taaagggttt ttgtgcgtgt 3840tttttttttt
tttcaccaaa attagatgga cttacagaat ttttaactta aaattggaat
3900ccaaaagcca gaagatcccc attatagttt atagttgtat tccctggaat
atttactggg 3960attaactgca aagcactctc agatgaatag tgtagtataa
cattttgaaa ctgaaataca 4020tttaccaaat taatttaacc acagcaatgt
gtgtggttca ttttagtcct tgagcatttt 4080tgattatcat acctgtcatg
ttttctgcag tgtagtgagt taacataaaa caacatcaat 4140acaaaagatc
ctctgtttcg agattaagca aaattcctca ttctcttcaa tgtgatagaa
4200taccacattg atctttcttt ggaggttagt aaaatatctt ttatgtattt
ttcagggctt 4260aacaagtaaa aatcaatgtt ttcatcaagt ctgatctttt
tgtcacccac tcttcattca 4320tttttccact aaggtgatag aaaagtctca
acagtttaag accgtaaggc tatgaactcc 4380aaatataatt gctgacaaga
taagcaatcc tcacgcatcc ttttgagagg aaataaaatc 4440ttagttgcaa
gattacatat tctgatttgg aatgctgagc tttttaaatg gaaatataga
4500aggacggctg aatcagcaaa aatcctttat gtagtttcat tctttgcaag
cttgaccagt 4560cattctgaaa caggctaact gaactgatac agtggcaagt
gaaaaagaca tgcctttaca 4620ggatgagtca aaggagtttt agaagaaaaa
tccaccagag aaagccaagc aaatacagtt 4680cagagttaca tttcttttcc
attttttcct gaactgaatc tttggcatgc atatcctgaa 4740ttgggttatt
gaatataaat ctagccttgt acaatggatg ccagatgact acatatttgc
4800tttggagcct aaggataagt ttcaaaagat ttgagtggag aagaaaagct
aaaactcttg 4860aagcacaagt ttctgttctc catgtactca agtgtacatg
aagttgtgaa aatttgtcca 4920cctctatcat catgttattc catgaaatta
caaaacaaat cttaaaaatg ttgtggcata 4980gattttctag atttaaaaag
taattaaatt aaatgaatta ctttattttt tgagacagag 5040tgtcactctg
ttgcccaggc tggagtgcag tggcactatg ttggctcact gcaacctctg
5100cctcctgggt tgaagaaatt ctcctgcctc aacctcccaa gtagctggga
ctacaggcat 5160gtgccaccac acccagctaa tttttgtatt tttggtagag
acggggtttc gccatgttgg 5220ctaggctggt ctcgaactcc tgacctcaag
tgatccaccc gtctcagcct cccaaagtgc 5280tgggattaca ggcataagcc
accatgacca gccttaaaaa gtaattttaa aatatcactg 5340gtaaaatgtg
gattcagtca tgattgagtg cagtttacca tgtgtgtgga catttattta
5400ttttaaaatt gtctgatcac caccttgagt aaaacacaag cagtcacaat
taaaatatat 5460tagtgagcag gagaaagcac agcatattat agcactgaat
gatttataaa cctattccag 5520ggtcataaaa tgtgtcaacg gcttttctat
agtaaggaga ctaggttcag atggttaatc 5580taagacaaat aaatgagata
agccatacac ttttacatcc tccatgtcct gtcttttctc 5640tgttcaaaat
aggatgttga caatgcgtct ctggcacgtc ttgaccttga acgcaaagtg
5700gaatctttgc aagaagagat tgcctttttg aagaaactcc acgaagaggt
tagtggagtg 5760actttcgggg aatgaatgag ggtaaggcag cccccacggt
tggcagagct gaccgtctgt 5820ctgttctttt tgcaggaaat ccaggagctg
caggctcaga ttcaggaaca gcatgtccaa 5880atcgatgtgg atgtttccaa
gcctgacctc acggctgccc tgcgtgacgt acgtcagcaa 5940tatgaaagtg
tggctgccaa gaacctgcag gaggcagaag aatggtacaa atccaaggta
6000ggaaacaaat cagtgcggct tcaaccaaag aaaagcattg tgttctcaaa
accccatacc 6060tgtgtgtgat tcctaaatat cctctagctc caatgcaaag
ctggctttga cttcttgctc 6120atattgtgtt tgccaccaca gcctccccac
cactcacatc acctccttta tttatttatt 6180tattttctta tttatttatg
agacagagtc ttgctctact gcccaggctg gagtgcagtg 6240gcaacatctt
ggcacactgc aacctccgcc tcccaggttc aagtgattct cctgcctcag
6300ccccctaaga gctggaacca caggcaagca ccaccatgcc cggctaattt
ttgtattttt 6360agtagagatg gggtttcacc atgttgacca ggcttctctc
aaactcctga cctcaggtga 6420tccaccctcc tcagcctccc aaaatgttgg
gattacaggc atgcgccacc acgcctggcc 6480acatcacctc cttcagaata
gcagactctc ttccccctaa ccttgcctcc aagtaaaccc 6540caatgccata
cctttgacct ccactgtgtt gaaatgagca ctgtagagtg aactctgaaa
6600atactaatgt cagtactcca ctgctctttc cctggctttc aaaacagaaa
tttaaaccta 6660tactggaaga cattcagtga gaaatatgat tttttttttc
taagagagtc aaaagacttg 6720aatgtgagca atctacattt ctgttttctt
cccaacagtt tgctgacctc tctgaggctg 6780ccaaccggaa caatgacgcc
ctgcgccagg caaagcagga gtccactgag taccggagac 6840aggtgcagtc
cctcacctgt gaagtggatg cccttaaagg aaccgtgagt accaaccctg
6900cagtaaaaga gggaaaataa tgacccattc tgctgactag gctcatgatg
atacctgaac 6960aaaatgttga gtgagtaaaa atgtatatca taatgcaaag
aaaatgagtt atcaagacag 7020actcaaaagg gacttcatgg aactcttgaa
ggttttagct tgcctatatc attgcttcta 7080atatgaagga cttggtactc
gcattctcca cctaaaatta gagtggtcgc catttgccgc 7140taatggaaat
tattgcagaa ggtctgtaaa tggttctggg aacagctggg tttttctgag
7200aaataacacc agacatcttt ctcaccccct gcagaatgag tccctggaac
gccagatgcg 7260tgaaatggaa gagaactttg ccgttgaagc tgctaactac
caagacacta ttggccgcct 7320gcaggatgag attcagaata tgaaggagga
aatggctcgt caccttcgtg aataccaaga 7380cctgctcaat gttaagatgg
cccttgacat tgagattgcc acctacagga agctgctgga 7440aggcgaggag
agcaggtagg gaactcagac ttggatgcgt gaactaatgg tgaccatttg
7500ttaggccctg tgccactggg ctctaagcag tgtcacattt aatctttaga
aagtttcttt 7560gaggtaactg ctttccactt tttgtagagg aggaatttga
attgagagag agtaagtgac 7620ttgctgaaaa agggttaatc aacagcagag
ctgggatttg aacccataac tctgtcaaag 7680cctccactcc taactcctgt
tcatgctcct gtggagaaaa tgcttgtagt aacatatttt 7740aaatgtacta
acaagaccag tcatgggaaa atgtttctga gacaaatctc tagtttatga
7800tttaaaacag tacgttttct tacgtgacga aaacaaaaag tgtgttaatt
tgttcccagt 7860ggttgaagtt atttgccaac aattttactg tttctcttca
tctgtttata ggatttctct 7920gcctcttcca aacttttcct ccctgaacct
gaggggtaag cattttattt ccctttagga 7980aaaacgtcag ctgcttgtaa
ccactgtgtt tatgtcaaag cattcatttt ttttaggata 8040tctgaaaaaa
tgccatataa gagaaaactc tataaaacat ctataatttt cgaacccaag
8100tacactcttg cattctatgc tttaagttaa atgcaaactc ctttttcctt
cttcctgctg 8160caagtactat ctcatcctga tgctcaagag tgtcagggcc
tgggtttcca aacagagact 8220accctaaaat tatttggcga gtagtacttt
acacaattgc ctctccccca caaatcataa 8280ttgtttcagt aaaatggtta
cttggttttt ccaagaaaaa actcgttttt actcattttt 8340ggcctgtttg
tttatttaga aactaatctg gattcactcc ctctggttga tacccactca
8400aaaaggacac ttctgattaa gacggttgaa actagagatg gacaggttgg
tatcttttaa 8460ggaaaaaata gggtaatctc agacaggagt tgatatattt
taaaatcagt gaatctgaat 8520ctcagataca gctggctaat ttgagaggtt
caggtttcat tcatgcctac taaaaaaaga 8580ataggcttct tcttccagca
gtacacacag ccaactaatt atttggctcc tggatgtgaa 8640gttgagatag
cagtcttcct gtgctccaga attagtgatt tgctttggtg cttaatttga
8700agtgggagta agcttcctta aaccacttcc taaagcagct acatgaaaca
gcttcactag 8760actacctcaa tatgaggaat gttttgatcc tggacatatg
gtgtcttcct acctccatac 8820tttatagatt cctaaaccca tctatataat
acaagcatgt gccatacgat catttagttt 8880cttattacct ccctatgcca
ggaaagaaat agttgcaatt tattgtagtc atcatgaaat 8940cttcccttgc
acataaattt aaaatgtacc tgctgcacat tttaatatgt cttaattgct
9000tttaaacttg gctgtattgt gtacaactat tataccatct tttataaaca
cagtttttta 9060agaaatttct ttttgtaagt tacaacattc cactggatcc
ttatattgcc tgtagtggaa 9120gagggtcttg tgtgtctgcc ccttctagtt
ttcactcatg cagaagcaac ataaccttct 9180gatttgcaca ataaattaca
tatatttagc aggattttta tttgccgtga tatataggat 9240aatttagtct
ttggcatgtg gcattatatt tattttggtt ttttttttta aacaggttat
9300caacgaaact tctcagcatc acgatgacct tgaataaaaa ttgcacacac
tcagtgcagc 9360aatatattac cagcaagaat aaaaaagaaa tccatatctt
aaagaaacag ctttcaagtg 9420cctttctgca gtttttcagg agcgcaagat
agatttggaa taggaataag ctctagttct 9480taacaaccga cactcctaca
agatttagaa aaaagtttac aacataatct agtttacaga 9540aaaatcttgt
gctagaatac tttttaaaag gtattttgaa taccattaaa actgcttttt
9600tttttccagc aagtatccaa ccaacttggt tctgcttcaa taaatctttg
gaaaaactc 96592466PRTHomo sapiens 2Met Ser Thr Arg Ser Val Ser Ser
Ser Ser Tyr Arg Arg Met Phe Gly1 5 10 15Gly Pro Gly Thr Ala Ser Arg
Pro Ser Ser Ser Arg Ser Tyr Val Thr 20 25 30Thr Ser Thr Arg Thr Tyr
Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 35 40 45Ser Arg Ser Leu Tyr
Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 50 55 60Ser Ser Ala Val
Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu65 70 75 80Gln Asp
Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 85 90 95Lys
Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 100 105
110Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn
115 120 125Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly
Lys Ser 130 135 140Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu
Leu Arg Arg Gln145 150 155 160Val Asp Gln Leu Thr Asn Asp Lys Ala
Arg Val Glu Val Glu Arg Asp 165 170 175Asn Leu Ala Glu Asp Ile Met
Arg Leu Arg Glu Lys Leu Gln Glu Glu 180 185 190Met Leu Gln Arg Glu
Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 195 200 205Asp Val Asp
Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 210 215 220Glu
Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu225 230
235 240Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln
Ile 245 250 255Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu
Arg Asp Val 260 265 270Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn
Leu Gln Glu Ala Glu 275 280 285Glu Trp Tyr Lys Ser Lys Phe Ala Asp
Leu Ser Glu Ala Ala Asn Arg 290 295 300Asn Asn Asp Ala Leu Arg Gln
Ala Lys Gln Glu Ser Thr Glu Tyr Arg305 310 315 320Arg Gln Val Gln
Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 325 330 335Asn Glu
Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 340 345
350Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu
355 360 365Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu
Tyr Gln 370 375 380Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu
Ile Ala Thr Tyr385 390 395 400Arg Lys Leu Leu Glu Gly Glu Glu Ser
Arg Ile Ser Leu Pro Leu Pro 405 410 415Asn Phe Ser Ser Leu Asn Leu
Arg Glu Thr Asn Leu Asp Ser Leu Pro 420 425 430Leu Val Asp Thr His
Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 435 440 445Thr Arg Asp
Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 450 455 460Leu
Glu46538515DNAMus musculus 3ctctgccact cttgctccgg gaccccagag
accccagcgc tcctacgatt cacagccacc 60gcgccctcat tcccttgttg cagtttttcc
agccgcagca agccagccca ccttcgaagc 120catgtctacc aggtctgtgt
cctcgtcctc ctaccgcagg atgttcggtg gctccggcac 180atcgagccgg
cccagctcca accggagcta tgtgaccacg tccacacgca cctacagtct
240gggcagcgca ctgcgcccca gcactagccg cagcctctat tcctcatccc
ccggtggcgc 300ctatgtgacc cggtcctcgg cagtgcgcct gcggagcagc
gtgccgggcg tgcggctgct 360tcaagactcg gtggacttct cgctggccga
cgccatcaac actgagttca agaacacccg 420caccaacgag aaggtagaac
tgcaggagct gaatgaccgc tttgccaact acatcgacaa 480ggtgcgcttc
ctcgagcagc agaacaaaat cctgctggct gagctcgagc agctcaaggg
540ccagggcaag tcgcgcctgg gcgacctgta cgaggaggag atgcgggagc
tgcgccggca 600ggtggatcag ctcaccaacg acaaggcccg tgtcgaggtg
gagcgggaca acctggccga 660ggacatcatg cggctgcgag agaagtaagg
cctgacctac gcgagtggtg gggtgtggga 720gggaggggag tcctgggcct
tgcactgggg ctgccacgcc cttggggatg tggctggggt 780ggcggttgtc
tggaggatag cagaggaagc gggccccacc ctgaacctaa actttgcagt
840gaacatttct cttttcgcct cactcaagca cttccattga actttttaga
aagtttctta 900ggtccttctt ctgggcttac agttaccaga caggaggaaa
gaatgggtgt gaagggttcc 960agacaaagag atggcaaagg catctgggat
attgggacag gggattggct gtaattgtaa 1020gggaagggca gtgattgtct
tttccagtgt gccccaactc cagctaacac ctgcagagag 1080ctgccacctc
gacaagttgc agtaactact gtgggtggag gtgtcacagc agctctggac
1140tcaaggcttg gcggcatttg tggttgggtg tggccgcccc gcccctggcg
gttttccagt 1200tcccctttga ttaatgtgct gctgcttcag attgcaggag
gagatgctcc agagagagga 1260agccgaaagc accctgcagt cattcagaca
ggtttgtaga cttctttttc acatgcagcc 1320agcagcccaa tggagccaac
ccgcgagcgg ttctaaaagt tacttccctt aggttttaaa 1380aggtgcagaa
cttcacgtct gcttgtaaag ccccctggcg gcggaaagcg cacagattga
1440aaaactccac tatttagggc agtctttgga acatgaaggc tttattttct
gcttcgtttc 1500cagatttttc tgatccccca cacccccgaa acatttctcc
tttcgttttt tgaaacatat 1560cgacattcgg atattgaatg gttacaattt
gattacattg tggattgtga aggtgaaatt 1620ggctaacttt cacaaggtca
taaaaaccac agttgcttcc tccagttgga aatgtagaat 1680actctggagg
atgagaaagt ttaactggaa ttaagccaag ttccctttct tccttcgaag
1740ttcggcactg cgtgaaagtt agcagaagag tcattgcaca accatttttg
aaatctaaca 1800agggtgaaaa gaagccatct gttcccgtag ctcaagggtg
ttaaaggttt ctatgggctt 1860cactatggaa tgtagatagg gacgttctgg
caaatgcggt ggctctggac agaaagaata 1920ggggcctttg tgttcccaga
gcagctttgc aacaggctac attcttattg aatatgtaat 1980gatgtaacca
cagttccaat tggacacaag tatttgctaa catccattat cttgtgtctg
2040ggccaggctt gtgaggtatg ccgtgtacaa agttcttaaa gctaaagtcc
tccctcacat 2100ttggaaaggc ccccttttag gggggtttgt agactcatta
gcaccctcca caaacaaaat 2160taaaccctaa actgaagaat ggagtatttt
atggagggag gatttgtttg tttgtgtttg 2220ttccagggtt aggcattacc
ttagcatccc gaagtggaca gatggccagt tcagtcttgt 2280ttggaacact
tgttaggatc aacagccaaa ctctccagat gaatgttcta aggtagcatt
2340ctgaaggcat ttgcatcctt aatggcagta gacgaatatg cagccccttt
cagtcactgg 2400gcattttcag tcatcaccaa aggaatgttt tctacaaagc
actgagttaa tacacaccat 2460ctcttatttg tggactaaaa attgtttcat
tcattcattt aaatgaaatg acacatttag
2520ctgaactttt tcgagaaggt tagtccaata tcatttatat attttttgat
ggcttagcag 2580aagtcagaaa tgaatgatac tactatttaa gttcttatat
tcttttttaa attagtattt 2640tctttgggac tgatagagta actcaacatt
atagttataa actatactgc aaatacagtt 2700gcttacaagg gaagtttcca
aacatttcct tgaaaggaaa caacatttca catgcaagat 2760tgaacagtct
gtcttaaaat agatcacttt ataaaaactc tgcagagaag tttaagtata
2820gtttcattgt aagtgttttg atctgtcatc ctaaaacaga caaagtcatt
gaaataacac 2880tgtgacagct gggacaggca gaaataccct ataggctgag
ccagggtgtt ttacacatta 2940aaaaaattag agaaggcaaa acaatatagt
tcaggattat atttcttttc cttcttgccc 3000gaggagcata tctctgcaaa
tgcaagacct ggattttgaa caatgaatta ctacttgata 3060cgaggctagc
ctgggaacct ggatgccaga taactgagtg cttattctaa attccaaaga
3120taagcatctg aaggtttgaa tacaggaaac aaaaaagagc atgcatatat
gttaaccctt 3180ctgagctcaa ttttaaatga tttttaaaaa atatgtaatg
tgtttgtgtc tgtgtgagtg 3240tataggacat ttctgcaggc ttgcatgagg
ccagaagagg gcacctgatg ccctggagtt 3300ggaatcataa accttcatga
actgctccat gtgggtgctg ggaaccaaac taaaatcctc 3360tgaaagaaca
gcattcttta ctactaagcc tcactttaga aaacatttta attttatttt
3420tgaagctctc atttttatat tacgtgtact caagcaaaca tgaagttgga
caatctcatc 3480aactactatc atcacaaaat tacagactta ttaaatgtga
cagaggttta aaactgaaaa 3540tgaatttttc catatagttc accataccat
gtcattgtgc atatacatgt gtttattttt 3600aacttgtcta ctagttagct
tcaatacaac caaatggttt cctattcatt tttaaagcta 3660agaatgaata
ttggaatgtg accctaaatg atttataaat ttatcaaggg tcatgaaatt
3720ttcagcacct tttctacaat aaggagaatg ggtttacatg gttaattttt
gaacaaataa 3780ataaataaat aaataaataa ataaataaat aaataagggg
ctgtagagac aggtcaatgg 3840ttaaaagcac tggctactct tttagggcac
ctggaattca atttgcagaa cccacagggc 3900tgcccacact cttctccagt
tccagggcat cttttgctct cttattgctt ttgtggatac 3960cacatgctcg
tggcatactt atatacatgc aggcaaaaca cctttataca caacataaag
4020tgaaaaaggg attaatataa ataagttaga taaaggacag actttatcac
cctccacatc 4080atcttttctc ttttcgaaat aggatgttga caatgcttct
ctggcacgtc ttgaccttga 4140acggaaagtg gaatccttgc aggaagaaat
tgcctttttg aagaaactgc acgatgaagt 4200aagtgacacc aatttctgtg
ggtgaacaaa gctgcgaccg tgtagtctac gacctctctg 4260tgtctgttct
ttctccagga gatccaggag ctgcaggccc agattcagga acagcatgtc
4320cagatcgatg tggacgtttc caagcctgac ctcactgctg ccctgcgtga
tgtgcgccag 4380cagtatgaaa gcgtggctgc caagaacctc caggaggccg
aggaatggta caagtccaag 4440gtatgaaatg agccagagtg gcaagaacct
ctagctctca gacacgtgcc tctaattcca 4500ttagtaacct ccagctctac
tcagaagctg gcttaaagct tggaccgcca ttgttgtttc 4560acagcacccc
ttccccctca tctccattca cagtttcctt tagtatggca gactcccttt
4620ccactcattg tcttccctga cttcaaagaa taccttactc tcatgctctt
gactgccacc 4680acttggaaag cattgcagta gagcaaatac tgtttgaaaa
cgcaatgctg gtgttctgct 4740tctctttccc tggttttcca aaagacgttc
agacaaattc taggaaacac acaggcagga 4800tgaagatgcc tctttgttct
aagtgagtga aaactcatgg aagtgaacaa tctctacttc 4860ttttcttttc
ttttcttttc ttttcttttc ttttcttttc ttttcttttc ttttctttct
4920cctcctcctc ctccttctcc tcctcctcct cctcctcctc ttcttcttct
tctacttctt 4980cttcttcttc ttcttcttct tcttcttctt cttcttcttc
ttcttcttct tcttcttctt 5040cttcttcttc ttcttcttcg actaagctca
caaccaaaaa caacctctat ttctgattcc 5100ttcttgacag tttgctgacc
tctctgaggc tgccaaccgg aacaacgatg ccctgcgcca 5160ggccaagcag
gagtcaaacg agtaccggag acaggtgcag tcactcacct gtgaagtgga
5220tgcccttaaa ggcactgtga gtactacagc agcaaagggg gggaaatacc
gtgctcagta 5280ctattctgct gactaggtta acaatgagac ctgtacaaat
aaattaaaca cacacggaca 5340cacacacaca cacttatcca aagagaatga
attatcaaga tagttttaag gattatttaa 5400tgagtacctt gaaagtctta
gtttacatat gttattgatt gtaataagag gggttttaga 5460ggttactcct
gtaacctcat cactctggag aatgaggcag ggggattata aattcacagt
5520taagctaggc tgcatgtaaa agtgttattt catcaaagca aaacatggaa
ctgggtgctt 5580gtgttctctg ttcaaagcta gtgggcacct accattaaaa
gaattactgt accttattta 5640tgaatatttt gggggacagc cgggttttct
gggaaatcac atgagaagcc atttttgctt 5700tctgcagaac gagtccctgg
agcgccagat gcgtgagatg gaagagaatt ttgcccttga 5760agctgctaac
taccaggaca ctattggccg cctgcaggat gagatccaaa acatgaagga
5820agagatggct cgtcaccttc gtgaatacca agatctgctc aatgttaaga
tggccctgga 5880cattgagatc gccacctaca ggaagctgct ggaaggcgag
gagagcaggt atagaaggca 5940aacgtgcatg tgtgaactaa ctcacagtcg
tctttctagg aagatctcat ttaacccaga 6000caccatatat atgaggaact
taacgttgca gagagtaact tgctgtggtc agagataatt 6060aatagcagag
tagatttgaa ctcacagcca tgcaaaagac aatacgttct ccctctataa
6120attcttctgg ttcatgtttc tgtgtggaaa aaaatatctt ccgaaattta
aatgggccaa 6180tgagaccaag catgggtaga aagttcttaa acaagtcact
aacagcaata gattttcatt 6240tggtggaaac aagaactgcg aaaacttgtt
cctgcttctt gaagtgcttt gttctcaagt 6300tttttgtgtg tttctttctc
tttttatagg atttctctgc ctctgccaac cttttcttcc 6360ctgaacctga
gaggtaagta cattgtttca tcttatggga aaaaaatgtc acaaggctgt
6420caccagtcac tctgcctgta gcatagcttc cacattttta aaaatatttt
ttattacgta 6480ttttcctcaa ttacatttcc aatgctatcc caaaagtccc
ccataccctc ccccccactc 6540ctctacccac ccactcccac agtaattctt
gattgaactg tgcttttcca aagaaaattc 6600aatgaaacat gatttctctt
ttataaatac atgtgtatag ccattttatt ttctgaatat 6660ttcttttggg
cttctgaggt tctgatagag ttaagtcact ttctcgcttc cgtttcttct
6720ctcgaaacct tccatgtact gccccctgac atatatggct gtcttttcag
ttcatggctt 6780ccttttgttt aaatgctgtt acacacacac acacacacac
acacacacac acacacacac 6840acactgtgta ttcttacata catgagtaca
atggctcatt ctgtataata ttacttacat 6900gtatgctttc aggctcgacc
atctggtccc ttttttatta tagttctcat gactgctgga 6960gaccaaaccc
agggcaatca gctaagctaa acccacagag ctccacccct agcctgatac
7020cctcagtttc aaactcgagt acattcttgc ctttgctacc ctgttaagta
tagactcagt 7080ctacttcctg ctaatggcaa agtcagtgaa ctactacctc
agcctgaatg aaggagccct 7140taggtgctgt gtactcaaat ggatagtgct
atgtaggatt atgtatgagt agcactttaa 7200ataaccataa aaataaagtc
atgatgcttt gggtaaaatg gtaatgtttt aaactttttc 7260ttatgttact
gccttttttt tttttttttt tttttaattc agaaactaac ctggagtcac
7320ttcctctggt tgacacccac tcaaaaagaa cactcctgat taagacggtt
gagaccagag 7380atggacaggt cagtattttt tagttaaaat atgggaaagt
ttaaaagaag gaatgatgaa 7440taaactatac aaccacttta aatatgtgtt
ggtccccttt aagtcagcaa gcagatatat 7500cagatatggc agctaactta
aggagtcccc gtggatactg gatgaatagc ccccaattcc 7560accaatgcaa
gaaccaacag tctatttggt cttgattagg acagtaaact tcctgcacac
7620catagtctgt gcactaaaca ggagtaaaac acccttaagg catctcttac
attggctgca 7680ttaaagtgtg tcacttaatg acatccgtga tatcagggat
agtttgacat tggacataca 7740gttctctctc agtgattgtc acctgcttat
atagtacgag gacccatatg tggtcaatca 7800ctttcttgtt gccactccat
gccagggaag acatagttac aatgagttat aattataaaa 7860gctcagcctt
gcatgaggat ataaaataca tttgccatac ctctacatat gccttagttg
7920cttttaagct ttgtttggaa ttgcaaaggc caacttccta aacacagttt
caaagtattt 7980tttgtcacac ctttccactg gatacttgta ttgtctgcag
gaagaggcca ccctgcctat 8040gcttctcctt agggcctcgt tctgcagagt
cagcataaac tcccagtctg ctcaaccaat 8100tctgtctgat tagggccata
tctccttacc atgagttgat ttttgtttct tttttgagca 8160ggtgatcaat
gagacttctc agcatcacga tgaccttgaa taaaaattgc acacacttgg
8220tgcaacagtg cagtaccagc aagaaggaaa aaaaaatcgt atcttaggaa
aacagctttc 8280aagtgccttt actgcagttt ttcaggagcg caagatagat
ttggaataga aagaagctca 8340gcacttaaca actgacaccc caaaagacgt
agaaaaggtt tacaaaataa tctagtttac 8400gaagaaatct tgtgctagaa
tactttttaa agtatttttg aataccatta aaactgcttt 8460tttccagtaa
atatctgacc aacttgttac tgcttcaata aatcttcaaa aatac 85154466PRTMus
musculus 4Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met
Phe Gly1 5 10 15Gly Ser Gly Thr Ser Ser Arg Pro Ser Ser Asn Arg Ser
Tyr Val Thr 20 25 30Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu
Arg Pro Ser Thr 35 40 45Ser Arg Ser Leu Tyr Ser Ser Ser Pro Gly Gly
Ala Tyr Val Thr Arg 50 55 60Ser Ser Ala Val Arg Leu Arg Ser Ser Val
Pro Gly Val Arg Leu Leu65 70 75 80Gln Asp Ser Val Asp Phe Ser Leu
Ala Asp Ala Ile Asn Thr Glu Phe 85 90 95Lys Asn Thr Arg Thr Asn Glu
Lys Val Glu Leu Gln Glu Leu Asn Asp 100 105 110Arg Phe Ala Asn Tyr
Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 115 120 125Lys Ile Leu
Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 130 135 140Arg
Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln145 150
155 160Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg
Asp 165 170 175Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu
Gln Glu Glu 180 185 190Met Leu Gln Arg Glu Glu Ala Glu Ser Thr Leu
Gln Ser Phe Arg Gln 195 200 205Asp Val Asp Asn Ala Ser Leu Ala Arg
Leu Asp Leu Glu Arg Lys Val 210 215 220Glu Ser Leu Gln Glu Glu Ile
Ala Phe Leu Lys Lys Leu His Asp Glu225 230 235 240Glu Ile Gln Glu
Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 245 250 255Asp Val
Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 260 265
270Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu
275 280 285Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala
Asn Arg 290 295 300Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser
Asn Glu Tyr Arg305 310 315 320Arg Gln Val Gln Ser Leu Thr Cys Glu
Val Asp Ala Leu Lys Gly Thr 325 330 335Asn Glu Ser Leu Glu Arg Gln
Met Arg Glu Met Glu Glu Asn Phe Ala 340 345 350Leu Glu Ala Ala Asn
Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 355 360 365Ile Gln Asn
Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 370 375 380Asp
Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr385 390
395 400Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu
Pro 405 410 415Thr Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Glu
Ser Leu Pro 420 425 430Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu
Ile Lys Thr Val Glu 435 440 445Thr Arg Asp Gly Gln Val Ile Asn Glu
Thr Ser Gln His His Asp Asp 450 455 460Leu Glu465512566DNAHomo
sapiens 5gggcgggcag gtgggactcg gcccccctcc cacaaccccg ctcccgggca
agctctcgag 60ccgcgaggcc ggggcgggga ggggccgggc cgggggcggc ctggcaggaa
gcggcgcgca 120ccttccgccg ccggaggagc aggtggctgc cgtgcgggtc
tgggccccag gcttcctgtg 180tgcgcgctcg tcctctgctg tttcccgccg
gagctcgttg ggcctccccg gcccgcccgg 240cccatggccc agacccccga
cggcatctcc tgtgagctcc gaggtaagcg ctggcccttc 300ctgccttctt
ggccgggagg aagtagtgca gccccaaaat cagaggccca cccagcgccc
360cagagggcct ggtcagaggt cctccctgct ccccaggagg gcaggcgccc
cagatcctct 420cccctccttc ctcgctggcc gcagataagc cccagggccc
cagcctggca cagactgtgg 480gcaccagtgg cttctgtgca aggactgaag
tcacccagca ggctgccctt ccacaggcga 540gatcaccagg ttcctgtggc
ccaaagaggt ggagctgctg ctgaaaacct ggctacccgg 600ggagggtgct
gtgcaaaacc atgtcctggt atggggcagg ggacagagcc ggggaggcgg
660ctgtggcccc acagaaagag cctcttgctc tgcccaggat atcagactgt
ctttccccag 720gcactgctac gatggagagc ctacctgctg cacaccacct
gcctcccgct gagggtgagt 780cccagggcct ggccacaccc ccgcccgcca
gcagctacct tggcaggggg ctgcatctgc 840agagtggtcc ttcttggcct
tgtgggccct gactttgcac cagcactggg ctctgggcag 900ccgacaggag
gggagtccag gcagatctgg ctctgcccca ggctgcccaa aggactggac
960ttccatgagg gcggggctgg gggcttggtc ccagctgatc taggcccttt
ctaggtggac 1020tgcacgttca gctacctgga ggtccaggcc atggcgctgc
aggagacacc ccctcaggtg 1080agacacctag taccctacct gggcctgcag
cctggtcttc atgctaccac catcacctgc 1140gcccatgtgt ggagccgagg
cctagtagtg ccccttccct aggtcacctt tgagctggag 1200tccctgcgtg
agctggtcct ggagtttcct ggtgtggccg ccctggaaca gctggcccag
1260cacgtggctg cagccatcaa gaaggtcttc cctcgctcga cccttgggtg
aggcctggca 1320aattcgaggg gctggcaggg gaggagggag tgcatgagaa
gggctgcttc ccatcccaga 1380ggctggaagt cctttgcccc cttctcctta
accccctacc aggaagctat tccggaggcc 1440cacaccagcc tccatgctgg
ctcggctgga gagaagcagc ccctcggagt ccactgaccc 1500ctgcagcccc
tgtggtaagg gtgaaggcag agccacaggc cttccagcct gccccacctc
1560tgcctcccca gacccgcaag ctgggggggc cccaaactga acagagccat
tcaggtccca 1620gccaccacct agtctgtggg tctggtcttc ctccatcgct
gatgttttgt ctctctcctt 1680ttccacatcg cacccctatc ccctccccag
gtggcttctt ggagacatac gaggctctgt 1740gtgactacaa tggcttccct
ttccgagagg agattcagtg ggtgagggta gggccctttt 1800gaagggctct
ggagacatct ggtcccccat gtgtgctgag cccctccctg ccccttgtgg
1860ccccaggcga actgtaagca tctccttctc acccaggacg tggacaccat
ttaccatcgc 1920cagggctgcc gccatttcag cctgggagac ttcagccacc
tcggcagtcg gtgtgtggcc 1980tgccaggatg ggagaggagg aagatcccgg
ggcccatatc cctgggcctc agtttctcca 2040tggaggggct gctgggcctg
ggacctggct ggagggccct gagctctgcc tctgttccca 2100ccctcccacc
agggacctgg ccttgagtgt ggctgccctg tcctacaacc tgtggttccg
2160gtgcctctcc tgtgtggaca tgaagctggt gagggggttc ggggtaaggg
cagggagggg 2220ccaagggtgt gggccagggt gcagcccgct gagggccagg
gtgcagcccg tgagccgccg 2280ccctctgctt ctcagagcct tgaggtctca
gaacagattc tgcacatgat gagtcagtca 2340tcacacctgg aggagctggt
gctggagacc tgcagcctga gggggtgagg gggacagggc 2400agggcttgga
gaggagagtc tggaggcttg ggactggggg ctagtggcct gggaggggtt
2460ggcaaaccag gggcagaatc tcatgcctgg ggtctggtcc ccagagactt
tgtccgacga 2520ctggcccagg cgctggcggg acactcaagc tctgggctgc
gggagctcag cctcgcgggg 2580aacctgctgg atgaccgagg tatgactgag
cctggggacc gcaggggtgg gcagcaggag 2640gaggtgagac ccacgtggct
gttcccaccc cccaaggcat gactgcactc agcagacacc 2700tcgagcgttg
tccaggagcc ctgaggagac tcagcctggc ccagacaggg ttgacaccgc
2760gaggtaggct ggatgaggga gggggtgagg ggaggggggt gggggtctgt
ccaactgctg 2820agtgaccccg acccaccacc aggaatgagg gctctgggcc
gggcactggc caccaatgcc 2880gccttcgact ccaccctgac ccacctggac
ctttctggga atcctggggc gctgggggcc 2940tccgaggaca gtggggtgag
tggctgtctt cagggtggga gcttggggtt gctcataagc 3000cctgggtagg
cgatccccca ctccatcgca cccctgtcct ccctccaggg cctctatagc
3060ttcctgagcc gtcctaacgt actgtcgttc ctgaatctcg caggcaccga
cactgccctg 3120gacactgtga gggggtgctc cgtgggggga tggatgaccg
gcagggcgga ctggagggcg 3180ggacggggag ggctcggtcc ccccgcgggt
gtagccaaca gcctcccccc gcagctcttc 3240gcagcggtat cccgaggctg
ctgcaccagc cttacccacc tcgacgcttc gaggaacgtc 3300ttctcccgca
cgtaaggggg acctgtcggg gccgggggag gctgctggaa gccgcctcct
3360tgcggcccca ggcccacctt cccacttccc ccaggaagtc ccgcgccgcg
ccggccgcgc 3420tgcagctctt cctcagccgc gcgcggacgc tgcggcacct
gggcctggcg ggctgcaagc 3480tgccgcccga cgcgctcagg tcagtgtcgg
accccggcca cgcccccgcg ggcgctccca 3540ccctgccctg gccttcgccc
ctccccgctc ctgcttctgt cgctcccaca acctccccca 3600gatcctggcc
ctgcctcctt cgttcgcacc ctggagcccc ctgtcccagc tcccgccacc
3660ccgtgtaacg tcctctccca gagccctttt ggatggcctc gcgctcaaca
cgcacctccg 3720cgacctgcac ctggacctca gcgcttgcga ggtgagcgcc
ggcccccaga agagaccaca 3780cattgggaga ggcgctggga ggcggaaggg
cagggccgtg ggccgcctgc ccctccccac 3840tcgcggccta agtgggtccc
acttcccacc tcccacctcc cacatacagc tgcgctcggc 3900cggcgcccag
gtgatacaag acttagtgtg cgacgcaggc gctgtgagct ccctggatct
3960ggcggataac ggtgaggctg caggagagcc catcctcgca tcatccactc
gattcccaat 4020ccccacccta cccttgcaac ttcgcctcgt gcgtgacccg
agtcaccccc aggcttcggc 4080tcagacatgg tgactctggt gctggccatc
gggagaagcc ggtccctgag acatgtggcg 4140cttggaagga acttcaacgt
ccggtgcaag tgagccccca ccctactcct gggcctccca 4200gacaacaccc
caccacccct gtcccccaca actgcggccc ctgcccacag ggagaccctg
4260gacgacgtcc tgcaccggat tgtccagctc atgcaggacg acgattgtgt
gagttcacgg 4320gaccttgcag ggcctcgggc aattagacca ctttggtcct
cctttctctt gttccctcag 4380accctgtgac ctgccctcac tgacccctga
ctccagccat caatggcttt ctcttaaccc 4440cagcctcttc agtctctgtc
ggtggctgag tctcggctga agctgggtgc cagcgtccta 4500ctccgggccc
tagccaccaa tcctaacctg accgcgctgg atatcagcgg caacgccatg
4560ggggacgcgg gcgccaagtt gctggccaag gcgctgcggg tcaactcgag
gctccggtgg 4620gcggggtcag aggggtggga ccagcgggca gggggcgcgg
tggagaggag ggcaccgggc 4680taaggggagg gactgaatga ggcggagcaa
atggagcagg ctgacgaggc gaatggacta 4740ggccgagggt tgggtggggc
gttgggaagc tccgtccccg actgaagcca ggcccggccc 4800aggtctgtgg
tctgggaccg gaaccacaca tctgctttgg gtctgctgga cgtggcgcag
4860gcgctggagc agaaccacag cctgaaggcc atgcctctgc cactgaacga
cgtggcccag 4920gcgcagcgca gccgcccgga actgacagca cgtgcagtcc
atcaggtggg cgtccccctc 4980ttcccttgcc cttctctgca cggtaactcc
gtccctcggc atttctcaat accccttgcc 5040cctagatcca agcctgtctc
ttgaggaaca accgcgcaga ccctgcctct tctgaccaca 5100cgacccgcct
tcagccactt ggtctggtct cagacccctc agagcaggtc aatgtcccct
5160ccccaaccac gagaggtagg gcatgaggag acctgtggca tccgggagcc
tccatgagtc 5220agagggtctg actttcctgg ggccagggtg cctgagccct
gctgtcccac acaaagtccc 5280tctccttgat ctggaggcgg ctaaacaccc
cttaaatagc tctccaaata acacccttgg 5340ctgcctaacg ttaagcctgt
aaacaggctg tcctgttaga gaggaatttt tatgtccttc 5400ctcaattttc
ccccaattgt agccccatct ctgtcctcac atatacgtga ctcccctccc
5460ctctccattg tgtgcccaaa cccagctgct ccttcactgt cttcatctcc
ctccactacc 5520ttatctgttg gagatgtttc tacctctcca ttcccaaata
cctcttcttt cctaagcttc 5580agagcccaaa ggtcttaatc cagacatcct
gctgggcttc atgctctgca cttctccaag 5640tgatgtcatc gtcgctcaca
aaccctgttg tctaccctgg agcccaatcc cactggtgcc 5700cacagccacc
cagtgctgtg gacagaggtt ggggcaccct tccaggtctc tcctggtcac
5760actggagccc tcataggcct ccttcgtcct gcctctagac caaccttcat
acatgccact 5820ccttaccccc acaccaatta tcccttgctc ctcctggtcc
ctcctccagg gctactcact 5880cccttttcta cccctctctc agtctatcct
ctgtgtggac agactgagct tctaaaacac 5940agacatgatt tacaactcct
ttccttccta ttctgggcac ttaggaagtg tatataaagt 6000ccttaaaatg
aaccaaagca acagatagtt ccttccctcc ttgaacagat agggttccaa
6060agtggctggt ctaagggtgt cagcttcagg acctccctct gttaaagagc
ctgggaggaa 6120ggcaggcagg atctgggaga ctgggagggg gctaggctga
gactgatccc catttcgccc 6180caggaagtga
atgaattgtg tcagtcggtg caggagcatg tggagctgct gggctgtggg
6240gctgggcccc agggtgaagc cgctgtgcgc caggccgagg atgccatcca
aaatgccaac 6300ttctctctca gcgtgagcac tccccctcct gctacaagga
cccttcccct cttagtcagg 6360tgtcagctcg caactgcttt tcctctttgg
ccctcagatt ctccccattc tatatgaagc 6420tggaagctcc ccaagccatc
actggcagct tgggcagaag ctggagggcc ttctgagaca 6480ggtgggcgag
gtctgccgcc aggacatcca ggtgagaggg tactcctgcc ccaaccccac
6540ctccgtttgc aggtttgact cccatccttt agttttaact gtgatatccc
ctgactcaat 6600attctgttgg agttggagcc tcaagccagc agcctggtgt
ctggccacat cctcaccatg 6660ctctgactga cctttgtcta ggacttcact
caggccacac tggacacagc aaggagcctc 6720tgcccacaga tgctgcaggg
atccagctgg agggagcagc tagagggggt cctggcaggc 6780tcgaggggcc
tcccggagct gctcccagag cagctgctgc aagatgcctt cactaggctc
6840aggtaggctg gatggggctg ggctgggcaa ggctgagcaa agccagccca
ttaacccctg 6900tcctctcctg cccttaggga catgcggcta tcaatcacgg
ggaccttggc agagagcatt 6960gtggctcagg ctttggcagg cctgagtgca
gcccgggatc agctggtgag ggggagatgt 7020gcacacactt tcgtgcaaac
acacacatgc agtgacttgg ccatctccct tgcaggggct 7080ctgtaatgtc
ttctggggtc atgtagccca gggctatttc agggtcccct tagttagcat
7140caatgggatc atggctgagg ccctacctgc catctttggc tgcttggtat
tgcaggtgga 7200gagtctggct cagcaggcaa cagtgacaat gccccctgcc
ctaccagcac cggatggagg 7260tgagcccagc ctccttgagc ctggggaatt
ggaaggtctt ttcttccccg aggagaagga 7320agaggagaag gagaaggtaa
gtggttttag aacacggggc atggcactcc cagtcttccc 7380atcttgctgt
ggagtgtgga aggtgaaagg cagctctttt gggttggtgc tctcctaccc
7440caggctgagt ttgtgccctc cccaccagga tgacagtcct ccacagaaat
ggcctgagct 7500cagccacggt cttcacctgg tccccttcat tcacagtaag
tcagggcctt gggggaggga 7560gtttacgtgg gtgggctgaa gctccattag
acttggggac ccggggacct ggatgaactc 7620attcagcctt gtctgggtac
ccaccagccc ttgactgggc caggtcgggc cccttgtgca 7680acctgcaaag
ctggggtctg ctgtggtcag cccggggcgg gacctgggcg gatctgggac
7740aggacaccgg ctcagctcgc ctccccgcgc ccctttccct accccaggga
cgcgcatgct 7800gggcggcggc gcggagccgc gcgcgctcgg ggccgcgctc
agcaccacgg acagcggcgg 7860cggcggggga ggggcggagg ggcagagggg
cggggggacg ggcggcgtag ccgggcccct 7920ccccgcgccc tgggcgggtc
ccccgccgcc ctagcgcctc cgccgccacc tccccgggct 7980cggcgctcgg
tgctcttctg gtgctgtccc ctcaggtgct gctgaggaag cggagccgga
8040gcccgagctg gcggctccgg gagaagatgc agagccgcag gcggggccgt
ccgcgcgcgg 8100ctctccgagc cctgccgccc ctgggccccc ggccggcccg
ctgccccgca tggacctgcc 8160actggcgggg cagcccctgc gccatccgac
ccgggcccgg ccgcggccgc gccgccagca 8220ccaccaccgc ccgccgccgg
ggggccccca ggtgagcacc cttcccccac tccggagcgc 8280gtggaattgg
ggatcacggg tggcccggcc gctcctcatg ggtggtagcg gtcaaggaga
8340gggggtggtg ggggcccaag gccacctggt cgtgcggccg cggtcacatc
ctggcttctt 8400cctgaccacc ccccacccca ggccatgcct gtgcgggacc
atgggtgtgc gggttccgtt 8460cggggtgtgc ctgggtgtgg gactccgtct
cggggcggcc cgcggcctcc gtggctgcgc 8520gagagagggt gtccgtcctc
cctccctccc ccggggctgc tgagagatgc cgggcagccg 8580ggtagccgag
ccgcggggcc aagcctgcgt ctgctgcgcg tccggcggcg gcgcgtgtgg
8640ggagatgcgt gtgtgggctg caagcccgcg ggggcagcgg gcactggcgg
agggcgggga 8700ggagccggct tgaggccccc cagagggtct gacgcagcag
ccggcgccac tgagccggca 8760gcaggccggg tggagtgggg gtggggtggg
ggacactgca gggaactgtt cggagcagag 8820ctggtggcaa gtgggaacgg
gtgaccccgg gggcacgtga gggctaggtt tgctggtgac 8880cgggtggctc
gggcgtgtag gatactctgt gggacaagga cgggtgtgga ctgggtgtgc
8940gggagccagc agcgagtgag gagtgcgtga aatctggagt ctctgtccag
cagcaggaca 9000gtaggaggct ggtatcagca gcccctaggg tcaccccagt
ctggaatcct ggagttattc 9060agtccaggct gccggccggg gggggggggg
ggtagaagcc agagttgcac tcaaccctga 9120cccctgaccc catgatgccc
cccaggtacc cccagccttg ccgcaggaag ggaatgggct 9180cagtgcccgc
gtggacgagg gcgtggagga attcttctcc aaaaggctga tccagcagga
9240tcgcctgtga gtgaggggca tctgctgggg gtgggagagg gtgggatgcc
tgatgggctt 9300tctcgctcac tgctgggtgt ccccacagct gggcccccga
ggaggacccg gccactgagg 9360ggggcgccac tcctgtcccc cgtacactgc
gaaagaagct gggcaccctc tttgccttca 9420agaagcctcg ttcaacgcgg
ggtccacgga ctgatctaga gaccagccct ggggcagctc 9480cccgaacccg
aaaaactaca tttggcgacc tactgcggcc gccaacccgt cccagccgtg
9540gtgaggagct tggtggggct gagggggaca ccagcagccc tgaccctgcc
ggcaggagcc 9600gacctcgcta cacaagagat agcaaggcct actcgatgat
actgctgcct gccgaggagg 9660aggcaacgct gggtgccaga cccgacaagg
tgaggcttgc tgatgggggg tggtgaaggc 9720gcttctggga cccagggcgc
ggactgtctc caactcgagc atctctgtcc ctagcggcgg 9780cccctggagc
ggggagaaac agaactggct ccatcctttg aacagcgggt acaagtaatg
9840ctgcagagga taggcgtcag ccgaggcagc gggggtgccg aaggcaagag
gaagcaagtg 9900agttgagggg acctgagcat gaagtgagag ggcagatggc
atgctgtggg tgacataagt 9960gaccaagatg gaggagactc atgacagata
ggtctaattg tcagttctac tccattctcc 10020tcgaaatggt tacagattcg
acctttcttc cctcttggct ttgacccagg cacaggccac 10080cagcatctcc
tctttggacc tgagaaagtc ttttctctgc aggtctaata gaaatctgag
10140gcctgggcca ggcgccatgg ctcacgcctg taatcccgac actttgggag
gctgaggcag 10200gtggattacc tgaggtcagg agttaagaga ccaacctggc
caacatggtg aaaccctgtc 10260tctactaaaa atacaaaaat tagccgggtg
tggcggtggg cacttgtagt cccagctact 10320tgggagggtg aggcacgaga
attgcttgaa cctgggagac aggttgcagt gagcctagat 10380cgtgccacta
cacactagcc tggacaacaa gagtgagact catctcaaaa aaagaaaaag
10440aaaaaaatct gaccttgtca cttgtgcttg aaatagcaag tcctccaggg
gcttcctctc 10500aagacactgt tcagactcca caacctgctt cagagccctg
tggggtcttg gccctggcca 10560ccttaaaacc tcactgcttt cctcccctgg
tgcaaatcag agcctccaca cacgtccctg 10620ggtggtctgg atgtcctccc
tgcctcgctt ccagtctcta attgtgggtt acgccaggtc 10680cctcctcagc
catccctgca gtgcccatgg ttcttccctg actctcctct gtgggccacc
10740ctgctaatgt ctctctcatt agagtcccaa agaaccccag ccctccatac
catccattca 10800atatcttaaa aaacaaaaaa caaaaacaaa caaaaaacat
gaagtcggcc tgaatttaga 10860aatattcaag tgtgcaaaga gttctaagag
ggctgtactg ggtttgccat gttcttgtcc 10920agcccatggt gggcattcag
tggcaggatt ataagaacaa gaacgaacaa aaggctaggg 10980tgtggggagc
gggcagggct ggaatctgat tgccctgttt cctgcagagc aaagatggcg
11040agatcaagaa agctggctca gatggtaagt gggaccctgg ggtgtggcag
tacatttgcc 11100aggaggtgtc cttatagaca gcccccaagg cacttgctct
ccttggggag gaaggggaga 11160ggccaggttt ttcttcccct cacctccaag
gtctggtacc tgagtcccca gctccgcctt 11220gcaggtgaca ttatggacag
ttccacggag gcccctccca tctcgatcaa gtcccgcacc 11280cactctgtgt
ctgctggtga gtgagggcca ctgtgtgtgt tggtagtggg agcagggaca
11340ggcaggagtt gggtcagact gttgttcaga cctatcgcca atgcctgacc
aggtcttggc 11400tgacaccttt ctccctacag acccttcctg cagacctggc
ccagggagcc aggggcctga 11460gtctgccacc tggaagacac tggggcagca
gttgaatgcg gagctcagga gccgtggttg 11520gggccaacag gatggtccag
gccctccctc ccctggtcaa agcccaagtc cctgcagaac 11580cagcccctcc
ccagacagcc tgggcctccc agaggaccct tgcttgggcc ccagaaatga
11640aggtaggcag gcacctgatt ccccacccca atcctggcct cggggctgga
ggagttcctg 11700ctgggaactc agctcctcta aggaccctga gggtgggagg
caagggctgg agtgggggca 11760gctgttggaa tacccctgat tccctggcct
ccctcagatg gccagctgag gccgaggcct 11820ctctcggcag ggcggcgagc
agtgtctgtg catgaggacc agctccaggc ccctgctggt 11880gaggggagac
acctccacgt gtgcttgaat gcaggagatg tgggagggtg ggcttctggg
11940gctcccttca tagctttggt ccttggaggg agccaccagt gtgtgaggtc
tcaagaaatc 12000agggagccag aagaccaggt gcaagggttt gacagcaagc
ccttccaact agcactggct 12060ccacttcccg aagagcagcc tctgccaggg
gtgaggacgc agggacgggg gatgctctga 12120aggcagcagt gtgtgtgagt
gcatgcttat gtgcactgga ggtggaagag aggggcaggg 12180gatggacaga
ccccaagcct tagcaaccca ccccaagcct ttctgtgtcc cttagaacgg
12240cccctgaggc tgcagcgctc ccccgtcctc aaacgcaggc caaaactcga
ggcacctcca 12300tccccaagcc taggtaagag ggggtccagg ccagctggga
gggtggcagg actgcttagc 12360ccagccctga cccttcctct ctctccctcc
ctcccctcac aggatctggc cttggaaccg 12420agcctctgcc cccacagccc
acagagccct ccagccctga gcggagccca ccctccccag 12480ccacagacca
aagaggcggc ggccccaatc cctgatcctc tcctctcctg ccgcatgaga
12540ttattttatt aaaaaactca aaggaa 1256661435PRTHomo sapiens 6Met
Ala Gln Thr Pro Asp Gly Ile Ser Cys Glu Leu Arg Gly Glu Ile1 5 10
15Thr Arg Phe Leu Trp Pro Lys Glu Val Glu Leu Leu Leu Lys Thr Trp
20 25 30Leu Pro Gly Glu Gly Ala Val Gln Asn His Val Leu Ala Leu Leu
Arg 35 40 45Trp Arg Ala Tyr Leu Leu His Thr Thr Cys Leu Pro Leu Arg
Val Asp 50 55 60Cys Thr Phe Ser Tyr Leu Glu Val Gln Ala Met Ala Leu
Gln Glu Thr65 70 75 80Pro Pro Gln Val Thr Phe Glu Leu Glu Ser Leu
Arg Glu Leu Val Leu 85 90 95Glu Phe Pro Gly Val Ala Ala Leu Glu Gln
Leu Ala Gln His Val Ala 100 105 110Ala Ala Ile Lys Lys Val Phe Pro
Arg Ser Thr Leu Gly Lys Leu Phe 115 120 125Arg Arg Pro Thr Pro Ala
Ser Met Leu Ala Arg Leu Glu Arg Ser Ser 130 135 140Pro Ser Glu Ser
Thr Asp Pro Cys Ser Pro Cys Gly Gly Phe Leu Glu145 150 155 160Thr
Tyr Glu Ala Leu Cys Asp Tyr Asn Gly Phe Pro Phe Arg Glu Glu 165 170
175Ile Gln Trp Asp Val Asp Thr Ile Tyr His Arg Gln Gly Cys Arg His
180 185 190Phe Ser Leu Gly Asp Phe Ser His Leu Gly Ser Arg Asp Leu
Ala Leu 195 200 205Ser Val Ala Ala Leu Ser Tyr Asn Leu Trp Phe Arg
Cys Leu Ser Cys 210 215 220Val Asp Met Lys Leu Ser Leu Glu Val Ser
Glu Gln Ile Leu His Met225 230 235 240Met Ser Gln Ser Ser His Leu
Glu Glu Leu Val Leu Glu Thr Cys Ser 245 250 255Leu Arg Gly Asp Phe
Val Arg Arg Leu Ala Gln Ala Leu Ala Gly His 260 265 270Ser Ser Ser
Gly Leu Arg Glu Leu Ser Leu Ala Gly Asn Leu Leu Asp 275 280 285Asp
Arg Gly Met Thr Ala Leu Ser Arg His Leu Glu Arg Cys Pro Gly 290 295
300Ala Leu Arg Arg Leu Ser Leu Ala Gln Thr Gly Leu Thr Pro Arg
Gly305 310 315 320Met Arg Ala Leu Gly Arg Ala Leu Ala Thr Asn Ala
Ala Phe Asp Ser 325 330 335Thr Leu Thr His Leu Asp Leu Ser Gly Asn
Pro Gly Ala Leu Gly Ala 340 345 350Ser Glu Asp Ser Gly Gly Leu Tyr
Ser Phe Leu Ser Arg Pro Asn Val 355 360 365Leu Ser Phe Leu Asn Leu
Ala Gly Thr Asp Thr Ala Leu Asp Thr Val 370 375 380Arg Gly Cys Ser
Val Gly Gly Trp Met Thr Gly Arg Ala Asp Trp Arg385 390 395 400Ala
Gly Arg Gly Gly Leu Gly Pro Pro Ala Gly Val Ala Asn Ser Leu 405 410
415Pro Pro Gln Leu Phe Ala Ala Val Ser Arg Gly Cys Cys Thr Ser Leu
420 425 430Thr His Leu Asp Ala Ser Arg Asn Val Phe Ser Arg Thr Lys
Ser Arg 435 440 445Ala Ala Pro Ala Ala Leu Gln Leu Phe Leu Ser Arg
Ala Arg Thr Leu 450 455 460Arg His Leu Gly Leu Ala Gly Cys Lys Leu
Pro Pro Asp Ala Leu Arg465 470 475 480Ala Leu Leu Asp Gly Leu Ala
Leu Asn Thr His Leu Arg Asp Leu His 485 490 495Leu Asp Leu Ser Ala
Cys Glu Leu Arg Ser Ala Gly Ala Gln Val Ile 500 505 510Gln Asp Leu
Val Cys Asp Ala Gly Ala Val Ser Ser Leu Asp Leu Ala 515 520 525Asp
Asn Gly Phe Gly Ser Asp Met Val Thr Leu Val Leu Ala Ile Gly 530 535
540Arg Ser Arg Ser Leu Arg His Val Ala Leu Gly Arg Asn Phe Asn
Val545 550 555 560Arg Cys Lys Glu Thr Leu Asp Asp Val Leu His Arg
Ile Val Gln Leu 565 570 575Met Gln Asp Asp Asp Cys Pro Leu Gln Ser
Leu Ser Val Ala Glu Ser 580 585 590Arg Leu Lys Leu Gly Ala Ser Val
Leu Leu Arg Ala Leu Ala Thr Asn 595 600 605Pro Asn Leu Thr Ala Leu
Asp Ile Ser Gly Asn Ala Met Gly Asp Ala 610 615 620Gly Ala Lys Leu
Leu Ala Lys Ala Leu Arg Val Asn Ser Arg Leu Arg625 630 635 640Ser
Val Val Trp Asp Arg Asn His Thr Ser Ala Leu Gly Leu Leu Asp 645 650
655Val Ala Gln Ala Leu Glu Gln Asn His Ser Leu Lys Ala Met Pro Leu
660 665 670Pro Leu Asn Asp Val Ala Gln Ala Gln Arg Ser Arg Pro Glu
Leu Thr 675 680 685Ala Arg Ala Val His Gln Ile Gln Ala Cys Leu Leu
Arg Asn Asn Arg 690 695 700Ala Asp Pro Ala Ser Ser Asp His Thr Thr
Arg Leu Gln Pro Leu Gly705 710 715 720Leu Val Ser Asp Pro Ser Glu
Gln Glu Val Asn Glu Leu Cys Gln Ser 725 730 735Val Gln Glu His Val
Glu Leu Leu Gly Cys Gly Ala Gly Pro Gln Gly 740 745 750Glu Ala Ala
Val Arg Gln Ala Glu Asp Ala Ile Gln Asn Ala Asn Phe 755 760 765Ser
Leu Ser Ile Leu Pro Ile Leu Tyr Glu Ala Gly Ser Ser Pro Ser 770 775
780His His Trp Gln Leu Gly Gln Lys Leu Glu Gly Leu Leu Arg Gln
Val785 790 795 800Gly Glu Val Cys Arg Gln Asp Ile Gln Asp Phe Thr
Gln Ala Thr Leu 805 810 815Asp Thr Ala Arg Ser Leu Cys Pro Gln Met
Leu Gln Gly Ser Ser Trp 820 825 830Arg Glu Gln Leu Glu Gly Val Leu
Ala Gly Ser Arg Gly Leu Pro Glu 835 840 845Leu Leu Pro Glu Gln Leu
Leu Gln Asp Ala Phe Thr Arg Leu Arg Asp 850 855 860Met Arg Leu Ser
Ile Thr Gly Thr Leu Ala Glu Ser Ile Val Ala Gln865 870 875 880Ala
Leu Ala Gly Leu Ser Ala Ala Arg Asp Gln Leu Val Glu Ser Leu 885 890
895Ala Gln Gln Ala Thr Val Thr Met Pro Pro Ala Leu Pro Ala Pro Asp
900 905 910Gly Gly Glu Pro Ser Leu Leu Glu Pro Gly Glu Leu Glu Gly
Leu Phe 915 920 925Phe Pro Glu Glu Lys Glu Glu Glu Lys Glu Lys Asp
Asp Ser Pro Pro 930 935 940Gln Lys Trp Pro Glu Leu Ser His Gly Leu
His Leu Val Pro Phe Ile945 950 955 960His Ser Ala Ala Glu Glu Ala
Glu Pro Glu Pro Glu Leu Ala Ala Pro 965 970 975Gly Glu Asp Ala Glu
Pro Gln Ala Gly Pro Ser Ala Arg Gly Ser Pro 980 985 990Ser Pro Ala
Ala Pro Gly Pro Pro Ala Gly Pro Leu Pro Arg Met Asp 995 1000
1005Leu Pro Leu Ala Gly Gln Pro Leu Arg His Pro Thr Arg Ala Arg
1010 1015 1020Pro Arg Pro Arg Arg Gln His His His Arg Pro Pro Pro
Gly Gly 1025 1030 1035Pro Gln Val Pro Pro Ala Leu Pro Gln Glu Gly
Asn Gly Leu Ser 1040 1045 1050Ala Arg Val Asp Glu Gly Val Glu Glu
Phe Phe Ser Lys Arg Leu 1055 1060 1065Ile Gln Gln Asp Arg Leu Trp
Ala Pro Glu Glu Asp Pro Ala Thr 1070 1075 1080Glu Gly Gly Ala Thr
Pro Val Pro Arg Thr Leu Arg Lys Lys Leu 1085 1090 1095Gly Thr Leu
Phe Ala Phe Lys Lys Pro Arg Ser Thr Arg Gly Pro 1100 1105 1110Arg
Thr Asp Leu Glu Thr Ser Pro Gly Ala Ala Pro Arg Thr Arg 1115 1120
1125Lys Thr Thr Phe Gly Asp Leu Leu Arg Pro Pro Thr Arg Pro Ser
1130 1135 1140Arg Gly Glu Glu Leu Gly Gly Ala Glu Gly Asp Thr Ser
Ser Pro 1145 1150 1155Asp Pro Ala Gly Arg Ser Arg Pro Arg Tyr Thr
Arg Asp Ser Lys 1160 1165 1170Ala Tyr Ser Met Ile Leu Leu Pro Ala
Glu Glu Glu Ala Thr Leu 1175 1180 1185Gly Ala Arg Pro Asp Lys Arg
Arg Pro Leu Glu Arg Gly Glu Thr 1190 1195 1200Glu Leu Ala Pro Ser
Phe Glu Gln Arg Val Gln Val Met Leu Gln 1205 1210 1215Arg Ile Gly
Val Ser Arg Gly Ser Gly Gly Ala Glu Gly Lys Arg 1220 1225 1230Lys
Gln Ser Lys Asp Gly Glu Ile Lys Lys Ala Gly Ser Asp Gly 1235 1240
1245Asp Ile Met Asp Ser Ser Thr Glu Ala Pro Pro Ile Ser Ile Lys
1250 1255 1260Ser Arg Thr His Ser Val Ser Ala Asp Pro Ser Cys Arg
Pro Gly 1265 1270 1275Pro Gly Ser Gln Gly Pro Glu Ser Ala Thr Trp
Lys Thr Leu Gly 1280 1285 1290Gln Gln Leu Asn Ala Glu Leu Arg Ser
Arg Gly Trp Gly Gln Gln 1295 1300 1305Asp Gly Pro Gly Pro Pro Ser
Pro Gly Gln Ser Pro Ser Pro Cys 1310 1315 1320Arg Thr Ser Pro Ser
Pro Asp Ser Leu Gly Leu Pro Glu Asp Pro 1325 1330 1335Cys Leu Gly
Pro Arg Asn Glu Asp Gly Gln Leu Arg Pro Arg Pro 1340 1345 1350Leu
Ser Ala Gly Arg Arg Ala Val Ser Val His Glu Asp Gln Leu 1355 1360
1365Gln Ala Pro Ala Glu Arg Pro Leu Arg Leu Gln Arg Ser Pro Val
1370 1375 1380Leu Lys Arg Arg Pro Lys Leu Glu Ala Pro Pro Ser Pro
Ser Leu 1385 1390 1395Gly Ser Gly Leu Gly Thr Glu Pro Leu Pro Pro
Gln Pro Thr Glu 1400 1405
1410Pro Ser Ser Pro Glu Arg Ser Pro Pro Ser Pro Ala Thr Asp Gln
1415 1420 1425Arg Gly Gly Gly Pro Asn Pro 1430 1435712186DNAMus
musculus 7ccgagtacgc ggaaggaaaa gtccctgagc gacagcaaca gtcaagattc
gaccatcctc 60ccacaacctc ccacccgggg cgaactcagc caacgaagcc ggggcgggga
ggggccgggc 120cgggggcggc ctggcaggaa gaagcgcgta ccttccgctg
caggaggagc aggtggctgc 180actgctgcct gggcccctgg cttcctgtgt
acgctcctgc cggctgcttt ttcccgccag 240agctcattgg gccgtcccgg
ccctatggca cagaccccag acgacatatc ctgtgaactg 300cgaggtaagc
cctgggagcc cacctggcca tgaagagcct gactccaaac cagacctctc
360ctctcggcgc cttagggaac ttgaccaggg gtttttgttc tggagggagg
gccagtgcct 420aaaagtccgc ttcatttctt cctagctgat ccacacatga
atacctgggc actcagtcta 480gcacagacct tgggcacaga gtggccctaa
tagaggagcc aaagtcaccc agtagactgt 540ctttccacag gcgagatcac
caggttcctg tggcccaagg aggcggagct gctgttgaaa 600acctggcttc
cccaggaggg tgccgagcaa agccatatcc tggtatggta gccaggagtg
660aagctcagga cagtggccag accctgcaca aagaaacttg atttccctag
agtattagtc 720ttttgtctcc ccccaggcac tgcttcgatg gagggcatat
ttgctgcaca cctgccttcc 780cctgagggtg agtcccaggc cgggccaaca
ccccttcccc ttcagcaagg gactgccttg 840cgcagctgtc ttctttgccc
atgctggctt ttactttcca acagcagaca ggagggaagt 900ctgggcaggt
ctagctcagg atgccacaaa atcatgggct gtggagagag gacctgggtt
960caattctccc accaccaggt gggctcacaa gtggttggaa ctctagttcg
aaggcaccca 1020ccaccgtctt ctggcatctt tgggaaccag gcacacaaga
gtggtacaga gacaaacatg 1080ccagcaaaca cccaatagta caatttttaa
attttaagaa caagctagga ggtggtggtg 1140cacgccttta gtcctggcac
tagggagaca gaggcaggca ggcctggtct acagagtgag 1200ctccaggaca
gccaggtcta cacagagaaa ccctgtctca ggaaagagaa agaaagaaag
1260aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aacgaactag
gctcaagaga 1320gtagcaacag tcagttggaa tgactctgat gctttccagg
tggactgtac attcagctac 1380ctggaggtcc aggccatggc actacaggaa
acaccccctc gggtaagaaa gctggacccc 1440aacttgaaca tacactccgc
ttgatcattt attcctacac atatcactct gaatggacag 1500cgcttccacc
acacagggat ccaaaaggct cctccttccc caggtcacct ttgagctgga
1560gtccctgcct gaactggtcc tggagtttcc ctgtgtggct gccctcgaac
agctggctca 1620gcatgtagct gctgccatca aaaaggtctt ccctcgctca
acccttgggt gaggcttaga 1680aaatccaagg ggtggggcag ggcctcagtg
aaagcttttc atccttcaag gagctagaag 1740tcccttttgc ctcttctcct
tatcccctgc ctaggaagct attccggaag cccacaccct 1800cgtctctgct
ggctcgactg gagagaagcc atcccttaga gtccaccata cccagcagtc
1860cgtgcggtga gggccaagtc agagccgcat aaaccttcca gtttgcctcc
atgcaatcct 1920agtctcttgg tattgggggg gctccccaaa gtgaacaggg
ccacttttat cactgccgcc 1980atctactatg gggctgacct tcccctgtct
ctgacttagt gcctgtctgt ttccctatca 2040ctcccccgac acctctctag
gtggcttctt ggaaacatac gaagctctgt gcgattacaa 2100tggcttccca
ttccgagagg agattcagtg ggtgagggta gggccctttt gggggagttc
2160tggggatgtt tgacgcccct tgtgtgtgct aagcccctct accctttgtg
gccccaggct 2220agctgtgact ttttttcttt acatctagga tgtggacact
atctaccatc gccagggctg 2280ccgccacttc tgccttggag atttcagcca
ctttggcagc cggtatgagg ccagccagga 2340ttgggaggcg agaactccag
cacccaaatt cctagtctgt ctgtagaggg gggatgctga 2400ctgagccctg
tgtttggaag gccctgagca ctgcattttc tcttccccgc gatagagacc
2460tggctttgag tgtagctgcc ttatcttata acctgtggtt ccggcgcctc
tcctgcgagg 2520acatgaagct ggtgagagag tacacacaaa agggagtgcc
aagggtgtaa gggtcaaagt 2580tcaacctgat gagtcacgac cctcttgctc
tcagagcctg gaggtctcag aacagattct 2640gcacatgacg agtcaatctt
cctatttgga ggagctggtg ttggaggctt gtggtctgcg 2700agggtgagag
gcctgagctg ggcgtgggaa cctgtgatct gcggagagac tgggaatcag
2760tcttaactgg ggtcttggtc ctcagagact tcgttaggcg actagcccag
gccctggcag 2820gacattttaa ttctggactt cgggagctca gcctgtctgg
gaacttgctg gatgacagag 2880gtatggcaga atctgggaga cccaaggcag
ccgagccgga agaggtgagg ttcacagagc 2940tgctctgtcc acaggtatgg
ctgcactcag cagacaccta gagcattgtc caggagcctt 3000gaggagactc
agcctagcac agacaggctt gacacctcga ggtgggtggg actggggagg
3060gttgggaggg ctcgaggtaa ggtgagcatg tcttgatact cagccgctcc
tcccacccac 3120caccaggaat gagagctcta ggcagggcac tggcaacgaa
tgccaccttt gactctaccc 3180tgacccacct ggatctttct gggaaccctg
gggcactggg accctcacag gatagtgggg 3240tgagtagcag tttttaaagt
cagaaactgg gacggccgag tcagtgggat gccagatcct 3300taggcaaccc
ctgcctccct ctctccctcc gtagggcctg tatactttcc tgagccgtcc
3360taacgtcctg gcgtatttga atcttgcagg cactgacgcc acgctaggca
cggtaagagt 3420gtggtcatgg gggatgcgtg gcagggcttg gctgcgcctg
agcagggaag gaaggagagc 3480ggagcgtggc agagaaagcc agggcttctg
gaaggttatc gctaatacca ccttcctctc 3540agctcttcac ggccttagct
ggtggctgct gctccagcct cacccatctg gaagcttcaa 3600ggaatatctt
ctctcgcatg taaggggcac caggcaggct cggaaggacg aggcttgagg
3660gtatcagctc ccctgagcgt aaatcccact tctgctctcc acccctcacc
gcaggaagtc 3720ccaagcggca ccagccgcgc tgcaacgctt ccttggcggt
accaggatgc tacggcacct 3780gggcctggcg ggctgcaagc tgccacctga
agcgctcagg tcagtcctcc cgtgcagtca 3840caaccttgag cagtgtctct
tgacctctac tgcctcaccc ctctatgaca cccataatct 3900ttcgtaaccc
caacctgcct ggcgcttatt cgttcgcacc gagtcccgtg ttcccagatc
3960ttgtcacctg tgtgttaccc ctctctcagg gcccttctag aaggtcttgc
actcaacact 4020cagatccatg atctgcacct agacctcagc gcgtgtgagg
taggtacccg gtcctggttg 4080tgagctgaga gcacgtccac attattgaga
gtgaggctgg gaggccttcc ctacccaggc 4140ataatcctga gtgcacccta
cctccacctc cagctccgct ccgtgggtgc ccaggtgata 4200caagacttgg
tttgtgatgc gggtgccttg agttccttgg atctgtcgga taatggtgag
4260gccgccaggg aacccatcca tccatgctcc tgttatttgt accagatccc
cagggtgggc 4320accctgacct ggtaggagtg atttgtgcat cactctggtt
acccctaggc tttggctccg 4380acatggtgac actggtgctt gccatcggga
ggagccggtc tctgaaacac gtggcccttg 4440gaaggaactt caacgttcgg
tgcaagtgag tcccaagctt ccccctgtac ctctcaagaa 4500ggactgcatc
acccatttag ttccctaaca gcagcccctt tccacaggga gaccctggac
4560gatgtcctgc atcggatagc ccagctaatg caggatgacg actgtgtgag
ttcacagagc 4620cctgtggggg gtcctcaagc aattaacgtc ttgtaatgct
tcttatgtat attccttcaa 4680accttctttg ctgaacctga gcccatgtat
ccatcagtgc cttcctttta accccagcct 4740ttgcagtcac tatccgtggc
tgagtcgcgg ttgaagcagg gtgccagcat cctgatccgg 4800gctttgggca
ccaatcctaa actgacagcg ctggatatca gtggcaatgc cataggggat
4860gctggggcca agatgctagc caaggctcta cgcgtcaaca ccaggctacg
gtgggtatga 4920tcatgataag ggctgggacc cgcaggagag ggcaagagtt
atataataga cgggtgtatg 4980ggtttaaggt atacatggtg atgagacagg
tgattggata aggccagagg gttgggcggg 5040gttctgcccc tgctgaagcc
tggtggggcc caggtctgtg atctgggacc ggaacaacac 5100atctgctctg
ggcctgctgg atgtggcgca agccctggaa cagaaccaca gcctcaagtc
5160catgccgctg ccactgaatg acgtaaccca ggctcatcgc agccggccag
aactcacaac 5220tcgagcggtc catcaggtgg gggtccgcgc ttctctctgc
ccttttgtgt gtggtgactc 5280caccccctgg cgtttctcac tatctctttg
actgcagatc caagcctgtc tctggaggaa 5340caaccaagta gactctactt
cggacctcaa gccctgcctt cagcccttag gtctgatttc 5400agaccactca
gagcaggtta gtgccccttg ccctaatctt gaatacctga gcacctgagt
5460cagagtctga cttttctgag ccacagtgct gagttctatg tctcaaacaa
tttccttttc 5520ttggtcaccg ttcttgaaac agcttcccgt gtaacatttg
gctgctttaa gggtttaaat 5580aggctgtcct tgctgtagcc tctttattcg
acttcctatt taagggctaa cctctcttta 5640ctgactgtgt ggctagctcc
agcagtccta tctctggctt taatttcctt tcattaaccc 5700atctttttgt
attattctta cctctgcatt cccaagcctc aattcttttg tttggttttg
5760gtttcttgag acagggtttc tctgtgtagc ctgggatatc cttgaactcc
cagagatctg 5820cttgcttctg cctcccaagt gctaggatta aaggcatgtg
ccaacactgc ccagcccaag 5880ccttgattga ttgattgatt gattgattga
ttgatttgag acagggtttc tctgtgtaat 5940ccttgccgtc ttggaattca
ctctgtagac caagctggcc tcgaactcag aaatccgcct 6000gcctctgcct
cccaagtgct gggattaaag gcgtgcgcca ccatacacac acacatacac
6060acaactgttc tctgtatgga tggttaaggt gacatctttg aaatcagagt
gaccaaagct 6120tctttccttc ctgttttagg cctggagaaa ataatcaagt
gatcagatag ggtttccctc 6180acagtttgtc ttcctgtagg aaaaccttgg
aagggagaca ggcagaatcg gggagactga 6240tgagaaacaa agggaggact
aatccatgac tccctcctgc ctgcccccca ggaggtgaac 6300gagctatgcc
agtcagtaca ggagcatatg gagctgctgg gctgtggggc tgggccccag
6360ggtgaggttg ccgtgcacca ggctgaggac gccatccaga atgccaactt
ctctctcagt 6420gtaagcaccc tctttcctgc tctgaggacc tttccgctcc
caatcatgtg ccagtttgca 6480agtccttttg ttccttggcc tccccagatc
ctccccattc tctatgaggc tgggagatcc 6540ccaagccacc actggcagct
gcagcagaag ctagagagcc tcctgggtca ggtgggcgag 6600atctgccgcc
aggacatcca ggtaagatac tagtcctgcc ccagccgcac ctccccatgc
6660aggcttgacc ctcattccac acgcttgtct gggataggcc cttagtcagc
agtggtttaa 6720tgggaactca caccttcaaa gccaaagggg ctgggttttg
gcatactgct aacattttgt 6780aacctttgcc caggacttca ctcagaccac
cctggatacc acaaggagcc tctgcccaca 6840gatgttgcag acacctggct
ggaggaagca gctagaggga gttctggtgg gctccggggg 6900cctcccagag
ctgcttccgg aacatctgct gcaagatgcc ttctctaggc tgaggtgagc
6960aagcccaact gggctgggca atgctggaca gagacagcac actaatcctc
actgtctcct 7020gcctttaggg acatgcgcct gtcaatcact gggaccctag
cagagagcat tgtggctcag 7080gctcttgcag gtcttcatgc agcccgagat
cgactggtga gggggaagct ttgaacacat 7140ttcatagagt aacttgttta
accctcacgg gcaaccctga aatgacttct ggggtcataa 7200gctagctact
tagttctgcc tatctttggg tggcctggta ttacaggtgg agaggctaac
7260tcagcaggca ccagtgacca tggcccctgc tgtaccacca ctgggtggaa
atgagctcag 7320cccccttgag actgggggat tggaagagct tttctttccc
acggagaagg aagaggagag 7380agaaaaggtg agtgtcttca gaatttcaag
cctaggaccc cggctggctt tctccttctt 7440gctctggaat gtagaaggtg
aggagcaggt ctgggtcatc ctaaccctag actgaggctg 7500tacccatccc
accaggatga gagttcttca tggaaatggc ttgagcctag taactgtttt
7560cacctggtct cctcccttca tggtaagtca ggccctggag taagagagtt
taatccaagt 7620ggactgaagc tctgttaaat ctggacactc tttcagccct
gtcccgggtg taccctagcc 7680cttccccgag ccaagccagg aagaaagcca
gagtcagctg ttctcagaac cctgtgggac 7740cagaacagaa taacactaag
acacctcctt ccctacctcc tcctcccctt tccctaaccc 7800caggacgcgc
atgcttggcg gctgcacaaa gtcgcgcgca ctcggggccg cgctcagcac
7860cacggacagc ggcgactggg ggaggggcgg gcggcgtagc cgggcccctc
cccgcgccct 7920gggcgggtcc ccgccgccct ccctagctcc tccgccacct
ccccgggttc gacgctctgt 7980gctcttctgg tgcttttgcc tcaggtgctg
ctgaggaagc ggaacgggac cccgagctgg 8040cagctccggg ggaagatgca
gagccgcagg ctgggccgtc tgcacgcggc tctccaagcc 8100ccgccgcccc
ggggccaccc gccggccctc tgcctcgcat ggacctgcca cccgccgggc
8160aacccctacg ccacccaacc cgagcccgac cgagaccacg tcgccagcac
caccaccgcc 8220cgccgccggg gggcccccag gtaagtgctt cccttccccc
tcgcccctct tgagggtcat 8280gggtggacca ttcactcttc acttgagata
gaagactgga agatgggttg tggaggccca 8340aggccaccgg atcgcgctct
atcatctttc tggccaccct catactcagg ccatggcaat 8400aacgggccat
ggtgtgtggc tttcctgtga ggagctacta gatggtggac cccctccttg
8460tagtggtctg ctctatgggt gaacatgcga gagcggatgt ccgccttgcc
ctccctctcc 8520taaggttgct gaaaaacact gggcagctgg accgcgggac
actcctgcgt ctgctgtgta 8580ccagcgggtg gatgtatgtg tgggttgggt
actggcaagg gtagtgggca ctggcagaag 8640gagaggagca gctggcctga
ggccccctga gggtctgacg cagcagcggc gccactgagc 8700cgggatgaga
ggccgggtgg tgtggtgtgg aggtggaagg ttagggtact gcagggaact
8760gttgggagta gaagggatgg catatttgca atgtgcgacc cataggtgtt
tgcttagtga 8820cagccaggtg gttcagggta tagcagcctc tggactgggt
gggtgcgctg tgacagcaat 8880gaagaatgaa agccagagtg gtacagacag
tctccagctc cgggatgtac tcaggccagg 8940ccactgggaa ggagaggatg
tctaggaaga gtcacagttc ccagtcctga ctcctaacct 9000cccaatgtct
cccaggtgcc cccagccctg cttcaagaag gaaatgggct cactgctcgc
9060gtggatgagg gtgtggagga gttcttctcc aaaaggctga tccagcagga
tcacttgtga 9120gtgagggtcg gttgactggg ggcggaggag ggtggaacat
ccccgagttt cttcactcac 9180tgatggttat tcctacagct gggccccaga
ggaggatcca gccactgagg gtggtgccac 9240tcctgtcccc cgcacacttc
gaaagaagct gggtacgctc tttgccttta agaaacctcg 9300ttcaacaagg
ggtccgcgac ctgacctgga gaccagccct ggagcagcag ctcgagccag
9360aaaatccaca cttggggatc tcctgcgacc accggcccgt ccaggccgtg
gtgaggaacc 9420tggaggggcg gaaggcggca ccagcagccc tgaccctgct
cgcagaaatc ggcctcggta 9480cacgcgggaa agcaaggcct actccatgat
cctgctacct gctgaggagg aagcagccgt 9540gggtaccaga cctgataagg
taaggccagg ggccggggct gaggctcctc aggaacagag 9600agcagtgggg
ttctctcacc acttaggcat ctctgtcctc agaggcggcc tctggaacgg
9660ggagacacag aactggctcc atcttttgag cagcgggtac aagtgatgct
acagaggatc 9720ggcgtgagcc gggccagtgg gggtgccgag agcaagagga
agcaagtgag ttgggggtga 9780actgcggggg caggtggcat gtggtaatct
gtgggtgaca tatgtgacca agaagggaga 9840aacacatggt gggaatagat
ctaattatca gttacatgtt ctcatccctc aagaggcaag 9900gaggagaact
ttcttccttc ttgcttctga cctggttcag atcttctagg gtatagggaa
9960ctcctttttc tgaagaagaa attaacagaa atttgacctt gttttacctg
aaagttctcc 10020aggaacttcc ttatccagat gccttatgtt ttttttttgt
tttaatattt atgtgagtac 10080actgtccctg ccttctgtct tcagacacac
cagaaactag cattggatcc cattacagat 10140agttgccggg agttgaactt
gggtcctctg gaagagtagt cagtgctctt agctgctgag 10200ccgtctctcc
agtcccttta tccagattcc taatcccgct gtgagatctc acaggacctt
10260ggtactggcc accttagacc tgttttcctt tgaagcctca cttggccatt
gatttttatt 10320ctctgactgt cgggtcatgt actggattat acaggctcct
ttccagcctt ccctgacacc 10380cttccatggt cacccggata acattactac
aatcatggtc tttattagga actacacctc 10440tgtatgccat ccatttaaat
agctttccag gaagaacaca tgcagtgaga cctggcctga 10500atgtagtgat
gttaaagtgt ggcaagtcat agaactaatt atctgctgga tgtggcggta
10560atctcagcat tcagaaaact ggggcaggag gattgcaagt aagactagcc
tgagttgtct 10620acagcaagac tatctcaaaa gcaaagtcta cctgtcatga
ccaacatgaa catttttgca 10680tgttagctat ctgtctatcc cagactgtaa
ggtcagaggg tggaaactgg ctttaccatg 10740ctctggccag cctatgctat
gcattctgta gctgggtttt aacaacatgg acagagacaa 10800ggctagggtc
agggcggcag ggctgctgcc tgactcatgt gtttcctaca gagtaaagac
10860ggcgagatca agaaggcagg ctctgatggt gagtaggacc ccacccggga
caaggagata 10920tatgttgggg aacaaggtgg cctcagataa cccctaaggc
tccctccctc caccactaag 10980gtctgacacc taagcctcta atccttcctt
gcaggtgaca ttatggacag ttccacagag 11040acccctccca tctcaatcaa
gtcccgtacc cactctgtgt ctgctggtga gtgagggcca 11100ctggatatgt
taaaggaggt gcaagggttg ggaggggatc ggactgttgc tcagaaccat
11160tccacagaca ggcttgggtg ttagctgaca ttgtcttctc tacccagatc
cctcatgcag 11220acctgggcca ggaggccagg ggcctgagtc tgccacctgg
aagacattgg gacagcagct 11280gaatgcagag ctcagaggcc gtggttgggg
ccaacaggat ggtccagggc ccccctcccc 11340atgtcccagc ccaagtcccc
gaagaaccag ccccgcccca gacatcctga gtctcccaga 11400ggacccctgc
ttgggcccta ggaatgaagg taggtaggca ccccactcct aggctaggaa
11460cccgactcat ctgggaaggc caaaggtggg aggcgaaggc tgggtgtggg
cggagtatgg 11520gaacgtcctc tgacatctcg gcctcctcta gatggccagc
tgaggccgag gcctctttcg 11580gcaggccggc gagcagtgtc tgtgcatgag
gaccagctcc aggcccccgc gggtgaggga 11640gacccctctg cctgtgcttg
agtgcaggag aaagggggag gtgggctcga tcggtcttgg 11700tccttggaca
gcgccacctc ctgaaggccc acctcagcta gggtgggagg acacttgctg
11760gacaatctat gggcgtagca tgtgcatggt tttgcgtgca ctcaaggtgg
accagagggt 11820tggggacagc cagtgagttt tttctgtatc ctttttagaa
cggcccctcc ggctgcagcg 11880ctcccctgtc ctcaagcgta ggccgaagct
cgaggcaccc ccatccccaa gcttaggtga 11940gagtgggcac gggccagctg
ggatgctgat acgactgctc agtacaagcc tagcattgtt 12000tctctccata
acccttcaca ggctctggcc ttggatccaa gcctcttcct ccgtacccca
12060cagaaccctc cagccctgag cggagccctc cctccccagc cacagaccaa
agaggcggcg 12120gccccaaccc ctgaatctct ctcctcctgc cgcatgaaat
tattttatta aaaaacttga 12180atgaaa 1218681295PRTMus musculus 8Met
Ala Gln Thr Pro Asp Asp Ile Ser Cys Glu Leu Arg Gly Glu Ile1 5 10
15Thr Arg Phe Leu Trp Pro Lys Glu Ala Glu Leu Leu Leu Lys Thr Trp
20 25 30Leu Pro Gln Glu Gly Ala Glu Gln Ser His Ile Leu Ala Leu Leu
Arg 35 40 45Trp Arg Ala Tyr Leu Leu His Thr Cys Leu Pro Leu Arg Val
Asp Cys 50 55 60Thr Phe Ser Tyr Leu Glu Val Gln Ala Met Ala Leu Gln
Glu Thr Pro65 70 75 80Pro Arg Val Thr Phe Glu Leu Glu Ser Leu Pro
Glu Leu Val Leu Glu 85 90 95Phe Pro Cys Val Ala Ala Leu Glu Gln Leu
Ala Gln His Val Ala Ala 100 105 110Ala Ile Lys Lys Val Phe Pro Arg
Ser Thr Leu Gly Lys Leu Phe Arg 115 120 125Lys Pro Thr Pro Ser Ser
Leu Leu Ala Arg Leu Glu Arg Ser His Pro 130 135 140Leu Glu Ser Thr
Ile Pro Ser Ser Pro Cys Gly Gly Phe Leu Glu Thr145 150 155 160Tyr
Glu Ala Leu Cys Asp Tyr Asn Gly Phe Pro Phe Arg Glu Glu Ile 165 170
175Gln Trp Asp Val Asp Thr Ile Tyr His Arg Gln Gly Cys Arg His Phe
180 185 190Cys Leu Gly Asp Phe Ser His Phe Gly Ser Arg Asp Leu Ala
Leu Ser 195 200 205Val Ala Ala Leu Ser Tyr Asn Leu Trp Phe Arg Arg
Leu Ser Cys Glu 210 215 220Asp Met Lys Leu Ser Leu Glu Val Ser Glu
Gln Ile Leu His Met Thr225 230 235 240Ser Gln Ser Ser Tyr Leu Glu
Glu Leu Val Leu Glu Ala Cys Gly Leu 245 250 255Arg Gly Asp Phe Val
Arg Arg Leu Ala Gln Ala Leu Ala Gly His Phe 260 265 270Asn Ser Gly
Leu Arg Glu Leu Ser Leu Ser Gly Asn Leu Leu Asp Asp 275 280 285Arg
Gly Met Arg Ala Leu Gly Arg Ala Leu Ala Thr Asn Ala Thr Phe 290 295
300Asp Ser Thr Leu Thr His Leu Asp Leu Ser Gly Asn Pro Gly Ala
Leu305 310 315 320Gly Pro Ser Gln Asp Ser Gly Gly Leu Tyr Thr Phe
Leu Ser Arg Pro 325 330 335Asn Val Leu Ala Tyr Leu Asn Leu Ala Gly
Thr Asp Ala Thr Leu Gly 340 345 350Thr Leu Phe Thr Ala Leu Ala Gly
Gly Cys Cys Ser Ser Leu Thr His 355 360 365Leu Glu Ala Ser Arg Asn
Ile Phe Ser Arg Met Lys Ser Gln Ala Ala 370 375 380Pro Ala Ala Leu
Gln Arg Phe Leu Gly Gly Thr Arg Met Leu Arg His385 390 395 400Leu
Gly Leu Ala Gly Cys Lys Leu Pro Pro Glu Ala Leu Arg Ala Leu 405 410
415Leu Glu Gly Leu Ala Leu Asn Thr Gln Ile His Asp Leu His Leu Asp
420 425
430Leu Ser Ala Cys Glu Leu Arg Ser Val Gly Ala Gln Val Ile Gln Asp
435 440 445Leu Val Cys Asp Ala Gly Ala Leu Ser Ser Leu Asp Leu Ser
Asp Asn 450 455 460Gly Phe Gly Ser Asp Met Val Thr Leu Val Leu Ala
Ile Gly Arg Ser465 470 475 480Arg Ser Leu Lys His Val Ala Leu Gly
Arg Asn Phe Asn Val Arg Cys 485 490 495Lys Glu Thr Leu Asp Asp Val
Leu His Arg Ile Ala Gln Leu Met Gln 500 505 510Asp Asp Asp Cys Pro
Leu Gln Ser Leu Ser Val Ala Glu Ser Arg Leu 515 520 525Lys Gln Gly
Ala Ser Ile Leu Ile Arg Ala Leu Gly Thr Asn Pro Lys 530 535 540Leu
Thr Ala Leu Asp Ile Ser Gly Asn Ala Ile Gly Asp Ala Gly Ala545 550
555 560Lys Met Leu Ala Lys Ala Leu Arg Val Asn Thr Arg Leu Arg Ser
Val 565 570 575Ile Trp Asp Arg Asn Asn Thr Ser Ala Leu Gly Leu Leu
Asp Val Ala 580 585 590Gln Ala Leu Glu Gln Asn His Ser Leu Lys Ser
Met Pro Leu Pro Leu 595 600 605Asn Asp Val Thr Gln Ala His Arg Ser
Arg Pro Glu Leu Thr Thr Arg 610 615 620Ala Val His Gln Ile Gln Ala
Cys Leu Trp Arg Asn Asn Gln Val Asp625 630 635 640Ser Thr Ser Asp
Leu Lys Pro Cys Leu Gln Pro Leu Gly Leu Ile Ser 645 650 655Asp His
Ser Glu Gln Glu Val Asn Glu Leu Cys Gln Ser Val Gln Glu 660 665
670His Met Glu Leu Leu Gly Cys Gly Ala Gly Pro Gln Gly Glu Val Ala
675 680 685Val His Gln Ala Glu Asp Ala Ile Gln Asn Ala Asn Phe Ser
Leu Ser 690 695 700Ile Leu Pro Ile Leu Tyr Glu Ala Gly Arg Ser Pro
Ser His His Trp705 710 715 720Gln Leu Gln Gln Lys Leu Glu Ser Leu
Leu Gly Gln Val Gly Glu Ile 725 730 735Cys Arg Gln Asp Ile Gln Asp
Phe Thr Gln Thr Thr Leu Asp Thr Thr 740 745 750Arg Ser Leu Cys Pro
Gln Met Leu Gln Thr Pro Gly Trp Arg Lys Gln 755 760 765Leu Glu Gly
Val Leu Val Gly Ser Gly Gly Leu Pro Glu Leu Leu Pro 770 775 780Glu
His Leu Leu Gln Asp Ala Phe Ser Arg Leu Arg Asp Met Arg Leu785 790
795 800Ser Ile Thr Gly Thr Leu Ala Glu Ser Ile Val Ala Gln Ala Leu
Ala 805 810 815Gly Leu His Ala Ala Arg Asp Arg Leu Val Glu Arg Leu
Thr Gln Gln 820 825 830Ala Pro Val Thr Met Ala Pro Ala Val Pro Pro
Leu Gly Gly Asn Glu 835 840 845Leu Ser Pro Leu Glu Thr Gly Gly Leu
Glu Glu Leu Phe Phe Pro Thr 850 855 860Glu Lys Glu Glu Glu Arg Glu
Lys Val Leu Leu Arg Lys Arg Asn Gly865 870 875 880Thr Pro Ser Trp
Gln Leu Arg Gly Lys Met Gln Ser Arg Arg Leu Gly 885 890 895Arg Leu
His Ala Val Ala Glu Lys His Trp Ala Ala Gly Pro Arg Asp 900 905
910Thr Pro Ala Ser Ala Val Tyr Gln Arg Val Asp Val Cys Val Gly Trp
915 920 925Val Pro Pro Ala Leu Leu Gln Glu Gly Asn Gly Leu Thr Ala
Arg Val 930 935 940Asp Glu Gly Val Glu Glu Phe Phe Ser Lys Arg Leu
Ile Gln Gln His945 950 955 960Phe Trp Ala Pro Glu Glu Asp Pro Ala
Thr Glu Gly Gly Ala Thr Pro 965 970 975Val Pro Arg Thr Leu Arg Lys
Lys Leu Gly Thr Leu Phe Ala Phe Lys 980 985 990Lys Pro Arg Ser Thr
Arg Gly Pro Arg Pro Asp Leu Glu Thr Ser Pro 995 1000 1005Gly Ala
Ala Ala Arg Ala Arg Lys Ser Thr Leu Gly Asp Leu Leu 1010 1015
1020Arg Pro Pro Ala Arg Pro Gly Arg Gly Glu Glu Pro Gly Gly Ala
1025 1030 1035Glu Gly Gly Thr Ser Ser Pro Asp Pro Ala Arg Arg Asn
Arg Pro 1040 1045 1050Arg Tyr Thr Arg Glu Ser Lys Ala Tyr Ser Met
Ile Leu Leu Pro 1055 1060 1065Ala Glu Glu Glu Ala Ala Val Gly Thr
Arg Pro Asp Lys Arg Arg 1070 1075 1080Pro Leu Glu Arg Gly Asp Thr
Glu Leu Ala Pro Ser Phe Glu Gln 1085 1090 1095Arg Val Gln Val Met
Leu Gln Arg Ile Gly Val Ser Arg Ala Ser 1100 1105 1110Gly Gly Ala
Glu Ser Lys Arg Lys Gln Ser Lys Asp Gly Glu Ile 1115 1120 1125Lys
Lys Ala Gly Ser Asp Gly Asp Ile Met Asp Ser Ser Thr Glu 1130 1135
1140Thr Pro Pro Ile Ser Ile Lys Ser Arg Thr His Ser Val Ser Ala
1145 1150 1155Asp Pro Ser Cys Arg Pro Gly Pro Gly Gly Gln Gly Pro
Glu Ser 1160 1165 1170Ala Thr Trp Lys Thr Leu Gly Gln Gln Leu Asn
Ala Glu Leu Arg 1175 1180 1185Gly Arg Gly Trp Gly Gln Gln Asp Gly
Pro Gly Pro Pro Ser Pro 1190 1195 1200Cys Pro Ser Pro Ser Pro Arg
Arg Thr Ser Pro Ala Pro Asp Ile 1205 1210 1215Leu Ser Leu Pro Glu
Asp Pro Cys Leu Gly Pro Arg Asn Glu Glu 1220 1225 1230Arg Pro Leu
Arg Leu Gln Arg Ser Pro Val Leu Lys Arg Arg Pro 1235 1240 1245Lys
Leu Glu Ala Pro Pro Ser Pro Ser Leu Gly Ser Gly Leu Gly 1250 1255
1260Ser Lys Pro Leu Pro Pro Tyr Pro Thr Glu Pro Ser Ser Pro Glu
1265 1270 1275Arg Ser Pro Pro Ser Pro Ala Thr Asp Gln Arg Gly Gly
Gly Pro 1280 1285 1290Asn Pro 129593295DNAHomo sapiens 9ccgccagccc
cgccagtccc cgcgcagtcc ccgcgcagtc cccgcgcagt cccagcgcca 60ccgggcagca
gcggcgccgt gctcgctcca gggcgcaacc atgtcgccat ttcttcggat
120tggcttgtcc aactttgact gcgggtcctg ccagtcttgt cagggcgagg
ctgttaaccc 180ttactgtgct gtgctcgtca aagagtatgt cgaatcagag
aacgggcaga tgtatatcca 240gaaaaagcct accatgtacc caccctggga
cagcactttt gatgcccata tcaacaaggg 300aagagtcatg cagatcattg
tgaaaggcaa aaacgtggac ctcatctctg aaaccaccgt 360ggagctctac
tcgctggctg agaggtgcag gaagaacaac gggaagacag aaatatggtt
420agagctgaaa cctcaaggcc gaatgctaat gaatgcaaga tactttctgg
aaatgagtga 480cacaaaggac atgaatgaat ttgagacgga aggcttcttt
gctttgcatc agcgccgggg 540tgccatcaag caggcaaagg tccaccacgt
caagtgccac gagttcactg ccaccttctt 600cccacagccc acattttgct
ctgtctgcca cgagtttgtc tggggcctga acaaacaggg 660ctaccagtgc
cgacaatgca atgcagcaat tcacaagaag tgtattgata aagttatagc
720aaagtgcaca ggatcagcta tcaatagccg agaaaccatg ttccacaagg
agagattcaa 780aattgacatg ccacacagat ttaaagtcta caattacaag
agcccgacct tctgtgaaca 840ctgtgggacc ctgctgtggg gactggcacg
gcaaggactc aagtgtgatg catgtggcat 900gaatgtgcat catagatgcc
agacaaaggt ggccaacctt tgtggcataa accagaagct 960aatggctgaa
gcgctggcca tgattgagag cactcaacag gctcgctgct taagagatac
1020tgaacagatc ttcagagaag gtccggttga aattggtctc ccatgctcca
tcaaaaatga 1080agcaaggccg ccatgtttac cgacaccggg aaaaagagag
cctcagggca tttcctggga 1140gtctccgttg gatgaggtgg ataaaatgtg
ccatcttcca gaacctgaac tgaacaaaga 1200aagaccatct ctgcagatta
aactaaaaat tgaggatttt atcttgcaca aaatgttggg 1260gaaaggaagt
tttggcaagg tcttcctggc agaattcaag aaaaccaatc aatttttcgc
1320aataaaggcc ttaaagaaag atgtggtctt gatggacgat gatgttgagt
gcacgatggt 1380agagaagaga gttctttcct tggcctggga gcatccgttt
ctgacgcaca tgttttgtac 1440attccagacc aaggaaaacc tcttttttgt
gatggagtac ctcaacggag gggacttaat 1500gtaccacatc caaagctgcc
acaagttcga cctttccaga gcgacgtttt atgctgctga 1560aatcattctt
ggtctgcagt tccttcattc caaaggaata gtctacaggg acctgaagct
1620agataacatc ctgttagaca aagatggaca tatcaagatc gcggattttg
gaatgtgcaa 1680ggagaacatg ttaggagatg ccaagacgaa taccttctgt
gggacacctg actacatcgc 1740cccagagatc ttgctgggtc agaaatacaa
ccactctgtg gactggtggt ccttcggggt 1800tctcctttat gaaatgctga
ttggtcagtc gcctttccac gggcaggatg aggaggagct 1860cttccactcc
atccgcatgg acaatccctt ttacccacgg tggctggaga aggaagcaaa
1920ggaccttctg gtgaagctct tcgtgcgaga acctgagaag aggctgggcg
tgaggggaga 1980catccgccag caccctttgt ttcgggagat caactgggag
gaacttgaac ggaaggagat 2040tgacccaccg ttccggccga aagtgaaatc
accatttgac tgcagcaatt tcgacaaaga 2100attcttaaac gagaagcccc
ggctgtcatt tgccgacaga gcactgatca acagcatgga 2160ccagaatatg
ttcaggaact tttccttcat gaaccccggg atggagcggc tgatatcctg
2220aatcttgccc ctccagagac aggaaagaat ttgccttctc cctgggaact
ggttcaagag 2280acactgcttg ggttcctttt tcaacttgga aaaagaaaga
aacactcaac aataaagact 2340gagacccgtt cgcccccatg tgacttttat
ctgtagcaga aaccaagtct acttcactaa 2400tgacgatgcc gtgtgtctcg
tctcctgaca tgtctcacag acgctcctga agttaggtca 2460ttactaacca
tagttattta cttgaaagat gggtctccgc acttggaaag gtttcaagac
2520ttgatactgc aataaattat ggctcttcac ctgggcgcca actgctgatc
aatgaaatgc 2580ttgttgaatc aggggcaaac ggagtacaga cgtctcaaga
ctgaaacggc cccattgcct 2640ggtctagtag cggatctcac tcagccgcag
acaagtaatc actaacccgt tttattctat 2700tcctatctgt ggatgtgtaa
atggctgggg ggccagccct ggataggttt ttatgggaat 2760tctttacaat
aaacatagct tgtaacttga gatctacaaa tccattcatc ctgattgggc
2820atgaaatcca tggtcaagag gacaagtgga aagtgagagg gaaggtttgc
tagacacctt 2880cgcttgttat cttgtcaaga tagaaaagat agtatcattt
cacccttgcc agtaaaaacc 2940tttccatcca cccattctca gcagactcca
gtattggcac agtcactcac tgccattctc 3000acactataac aagaaaagaa
atgaagtgca taagtctcct gggaaaagaa ccttaacccc 3060ttctcgtgcc
atgactggtg atttcatgac tcataagccc ctccgtaggc atcattcaag
3120atcaatggcc catgcatgct gtttgcagca gtcaattgag ttgaattaga
attccaacca 3180tacattttaa aggtatttgt gctgtgtgta tattttgata
aaatgttgtg acttcatggc 3240aaacaggtgg atgtgtaaaa atggaataaa
aaaaaaaaaa gagtcaaaaa aaaaa 329510706PRTHomo sapiens 10Met Ser Pro
Phe Leu Arg Ile Gly Leu Ser Asn Phe Asp Cys Gly Ser1 5 10 15Cys Gln
Ser Cys Gln Gly Glu Ala Val Asn Pro Tyr Cys Ala Val Leu 20 25 30Val
Lys Glu Tyr Val Glu Ser Glu Asn Gly Gln Met Tyr Ile Gln Lys 35 40
45Lys Pro Thr Met Tyr Pro Pro Trp Asp Ser Thr Phe Asp Ala His Ile
50 55 60Asn Lys Gly Arg Val Met Gln Ile Ile Val Lys Gly Lys Asn Val
Asp65 70 75 80Leu Ile Ser Glu Thr Thr Val Glu Leu Tyr Ser Leu Ala
Glu Arg Cys 85 90 95Arg Lys Asn Asn Gly Lys Thr Glu Ile Trp Leu Glu
Leu Lys Pro Gln 100 105 110Gly Arg Met Leu Met Asn Ala Arg Tyr Phe
Leu Glu Met Ser Asp Thr 115 120 125Lys Asp Met Asn Glu Phe Glu Thr
Glu Gly Phe Phe Ala Leu His Gln 130 135 140Arg Arg Gly Ala Ile Lys
Gln Ala Lys Val His His Val Lys Cys His145 150 155 160Glu Phe Thr
Ala Thr Phe Phe Pro Gln Pro Thr Phe Cys Ser Val Cys 165 170 175His
Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Gln Cys Arg Gln 180 185
190Cys Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Val Ile Ala Lys
195 200 205Cys Thr Gly Ser Ala Ile Asn Ser Arg Glu Thr Met Phe His
Lys Glu 210 215 220Arg Phe Lys Ile Asp Met Pro His Arg Phe Lys Val
Tyr Asn Tyr Lys225 230 235 240Ser Pro Thr Phe Cys Glu His Cys Gly
Thr Leu Leu Trp Gly Leu Ala 245 250 255Arg Gln Gly Leu Lys Cys Asp
Ala Cys Gly Met Asn Val His His Arg 260 265 270Cys Gln Thr Lys Val
Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Met 275 280 285Ala Glu Ala
Leu Ala Met Ile Glu Ser Thr Gln Gln Ala Arg Cys Leu 290 295 300Arg
Asp Thr Glu Gln Ile Phe Arg Glu Gly Pro Val Glu Ile Gly Leu305 310
315 320Pro Cys Ser Ile Lys Asn Glu Ala Arg Pro Pro Cys Leu Pro Thr
Pro 325 330 335Gly Lys Arg Glu Pro Gln Gly Ile Ser Trp Glu Ser Pro
Leu Asp Glu 340 345 350Val Asp Lys Met Cys His Leu Pro Glu Pro Glu
Leu Asn Lys Glu Arg 355 360 365Pro Ser Leu Gln Ile Lys Leu Lys Ile
Glu Asp Phe Ile Leu His Lys 370 375 380Met Leu Gly Lys Gly Ser Phe
Gly Lys Val Phe Leu Ala Glu Phe Lys385 390 395 400Lys Thr Asn Gln
Phe Phe Ala Ile Lys Ala Leu Lys Lys Asp Val Val 405 410 415Leu Met
Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu 420 425
430Ser Leu Ala Trp Glu His Pro Phe Leu Thr His Met Phe Cys Thr Phe
435 440 445Gln Thr Lys Glu Asn Leu Phe Phe Val Met Glu Tyr Leu Asn
Gly Gly 450 455 460Asp Leu Met Tyr His Ile Gln Ser Cys His Lys Phe
Asp Leu Ser Arg465 470 475 480Ala Thr Phe Tyr Ala Ala Glu Ile Ile
Leu Gly Leu Gln Phe Leu His 485 490 495Ser Lys Gly Ile Val Tyr Arg
Asp Leu Lys Leu Asp Asn Ile Leu Leu 500 505 510Asp Lys Asp Gly His
Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu 515 520 525Asn Met Leu
Gly Asp Ala Lys Thr Asn Thr Phe Cys Gly Thr Pro Asp 530 535 540Tyr
Ile Ala Pro Glu Ile Leu Leu Gly Gln Lys Tyr Asn His Ser Val545 550
555 560Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly
Gln 565 570 575Ser Pro Phe His Gly Gln Asp Glu Glu Glu Leu Phe His
Ser Ile Arg 580 585 590Met Asp Asn Pro Phe Tyr Pro Arg Trp Leu Glu
Lys Glu Ala Lys Asp 595 600 605Leu Leu Val Lys Leu Phe Val Arg Glu
Pro Glu Lys Arg Leu Gly Val 610 615 620Arg Gly Asp Ile Arg Gln His
Pro Leu Phe Arg Glu Ile Asn Trp Glu625 630 635 640Glu Leu Glu Arg
Lys Glu Ile Asp Pro Pro Phe Arg Pro Lys Val Lys 645 650 655Ser Pro
Phe Asp Cys Ser Asn Phe Asp Lys Glu Phe Leu Asn Glu Lys 660 665
670Pro Arg Leu Ser Phe Ala Asp Arg Ala Leu Ile Asn Ser Met Asp Gln
675 680 685Asn Met Phe Arg Asn Phe Ser Phe Met Asn Pro Gly Met Glu
Arg Leu 690 695 700Ile Ser705113313DNAMus musculus 11cttgggtcgc
caggcccgcg ccagtccccg ccatccgagc aacagcggcg ctgctctggg 60accgcggccg
cgacaccagg gaacaaccat gtcaccgttt cttcgaatcg gtttatccaa
120ctttgactgt gggacctgcc aagcttgtca gggagaggca gtgaacccct
actgcgctgt 180gcttgtcaaa gagtatgtgg aatcagaaaa tgggcagatg
tacatccaga aaaagccaac 240catgtaccca ccttgggaca gcacctttga
cgcccacatt aacaagggaa gggtgatgca 300gatcatcgtg aagggcaaga
atgtagacct catctcagaa acaaccgtgg aactctactc 360cctggcggag
agatgccgca agaacaatgg gcggacagaa atatggttag agctgaaacc
420tcaaggccga atgctaatga atgcaagata ctttctggaa atgagtgaca
caaaggacat 480gagtgagttt gagaatgaag gattctttgc actgcatcag
cgccgaggag ccatcaaaca 540ggccaaagtc caccatgtca agtgtcacga
gttcacggcc acctttttcc ctcaacccac 600attttgctct gtctgccatg
aatttgtctg gggcctgaac aagcagggtt accagtgccg 660acagtgtaat
gcagcgattc acaagaagtg cattgataaa gtgatagcca agtgcacagg
720atccgcaatc aatagccgag aaaccatgtt ccataaggag agattcaaga
tcgacatgcc 780acacagattc aaagtctaca actacaagag tccaaccttc
tgtgagcact gtggtaccct 840gctctggggg ctggcgaggc aaggactcaa
atgtgatgca tgtggcatga acgtccacca 900ccgatgccag acaaaggttg
ccaatctttg tggtataaac cagaagctaa tggctgaagc 960actagcgatg
attgaaagca cccaacaggc tcgctcctta cgagattcag aacacatctt
1020ccgagaaggc ccagttgaaa ttggtctccc atgctccacc aaaaacgaaa
ccaggccacc 1080atgcgtacca acacctggga aaagagaacc ccagggcatt
tcctgggatt cccctttgga 1140tgggtcaaat aaatcggccg gtcctcctga
acccgaagtg agcatgcgca ggacttcact 1200gcagctgaaa ctgaagatcg
atgacttcat cctgcacaag atgttgggaa aaggaagttt 1260tggcaaggtc
ttcctggcag agttcaagag aaccaatcag tttttcgcaa taaaagcctt
1320aaagaaagat gtggtgttga tggatgatga cgtcgagtgt acaatggtgg
aaaagagggt 1380tctgtccttg gcatgggagc atccatttct aacacacatg
ttctgcacat tccagaccaa 1440ggaaaatctc tttttcgtga tggagtatct
caatggaggc gacttaatgt accacatcca 1500aagttgccac aaatttgatc
tttccagagc cacgttttat gctgctgagg tcatccttgg 1560tctgcagttc
cttcattcca aaggaattgt ctacagggac ctgaagcttg ataatatcct
1620gttagacaga gatggacata tcaaaatagc agactttggg atgtgcaaag
agaacatgct 1680aggagatgcg aagacaaata ctttctgtgg aactcctgac
tacattgctc cggagatctt 1740gctgggtcag aagtacaacc attccgtcga
ctggtggtcc ttcggggtgc tcgtttatga 1800gatgctgatt ggccagtccc
ccttccacgg gcaggacgag gaggagctgt tccactccat 1860ccgcatggac
aaccccttct acccgaggtg gctcgaaagg gaggccaagg accttctagt
1920gaagcttttt gtgagagaac ctgagaagag gctgggagtg agaggagaca
tccgccagca 1980tcctttgttt cgagagatca actgggaaga gcttgaaagg
aaagagattg acccaccctt 2040cagaccaaaa gtgaaatcac catatgactg
tagcaatttc gacaaggaat tcctaagtga 2100gaaaccccgg ctatcattcg
ccgacagagc
actcatcaac agcatggacc agaacatgtt 2160cagcaacttt tccttcatta
acccagggat ggagactctc atttgctcct gaacctcatc 2220tgtctccaga
ctggaaggga tttgccttct ctctgggaac tggttcaagt aacacttctg
2280ggggtggggg tctctttttc acgttagaga agaaaagaaa cactgcaaag
gcagggagga 2340ctgctgagct ccttgtgtga cttgttacct acagcacaaa
ccacgcctac ttcactaatg 2400acatcatccc taatgacatc atcccgttat
atctcctgga atctctcaca gcagcccttg 2460aagttagatc attattaact
ctagtcattt acttgaaaga tggttcccga tgctgtgaaa 2520gattcgaaat
gcagttctgc tcttgcccta gacaacagct gctggttggt gatgaaccaa
2580ggcgcaagtg gaacagattt ctcaagactg gagcagtgat cgcctgttat
agaagtcaat 2640tccactcaac cacagagaag gaaccactaa gccacgttga
tgtgtgcatg tctgtggaaa 2700tgtcgatgac agaagggagg gaaaggggaa
gctctgagca gattgtaatg ggaagctctc 2760caataaacat agcatgaaac
ttgaaattta caaatctgtt cattctggct agccccaaaa 2820ttcccaaggc
agaggaaagt aaagggcagt gagcttagca gagccctttg tcgccaacag
2880ggaagggtaa ggatgtcgcc tacgtggaac atcttataca cacagaagga
aagtataacc 2940aacaagggca gggtggttta cagctgccaa tcaaacctgc
cctcccccct ctgttctcag 3000ttgatctctc tgtcagcgta ggtaggcact
cattaccatc ctcccatcat acaagaaata 3060aaatgcatga ctcttctaag
ataaagaaaa ccaatccctt atcacgttgt tcccagtgat 3120ttgatggcaa
ataagtccct ccttaggcat cctgcaagac aacccaaccc atgcatgcta
3180tttgcagtag tcagtcctgt tgagttagag tcctaactat acacaatatc
gtgcgatgtt 3240tatatatgtt gatgagatgt tgtgatgata acgtggatat
gtaaaaggga ataaaagaag 3300aaagaaagat gcc 331312707PRTMus musculus
12Met Ser Pro Phe Leu Arg Ile Gly Leu Ser Asn Phe Asp Cys Gly Thr1
5 10 15Cys Gln Ala Cys Gln Gly Glu Ala Val Asn Pro Tyr Cys Ala Val
Leu 20 25 30Val Lys Glu Tyr Val Glu Ser Glu Asn Gly Gln Met Tyr Ile
Gln Lys 35 40 45Lys Pro Thr Met Tyr Pro Pro Trp Asp Ser Thr Phe Asp
Ala His Ile 50 55 60Asn Lys Gly Arg Val Met Gln Ile Ile Val Lys Gly
Lys Asn Val Asp65 70 75 80Leu Ile Ser Glu Thr Thr Val Glu Leu Tyr
Ser Leu Ala Glu Arg Cys 85 90 95Arg Lys Asn Asn Gly Arg Thr Glu Ile
Trp Leu Glu Leu Lys Pro Gln 100 105 110Gly Arg Met Leu Met Asn Ala
Arg Tyr Phe Leu Glu Met Ser Asp Thr 115 120 125Lys Asp Met Ser Glu
Phe Glu Asn Glu Gly Phe Phe Ala Leu His Gln 130 135 140Arg Arg Gly
Ala Ile Lys Gln Ala Lys Val His His Val Lys Cys His145 150 155
160Glu Phe Thr Ala Thr Phe Phe Pro Gln Pro Thr Phe Cys Ser Val Cys
165 170 175His Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Gln Cys
Arg Gln 180 185 190Cys Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys
Val Ile Ala Lys 195 200 205Cys Thr Gly Ser Ala Ile Asn Ser Arg Glu
Thr Met Phe His Lys Glu 210 215 220Arg Phe Lys Ile Asp Met Pro His
Arg Phe Lys Val Tyr Asn Tyr Lys225 230 235 240Ser Pro Thr Phe Cys
Glu His Cys Gly Thr Leu Leu Trp Gly Leu Ala 245 250 255Arg Gln Gly
Leu Lys Cys Asp Ala Cys Gly Met Asn Val His His Arg 260 265 270Cys
Gln Thr Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Met 275 280
285Ala Glu Ala Leu Ala Met Ile Glu Ser Thr Gln Gln Ala Arg Ser Leu
290 295 300Arg Asp Ser Glu His Ile Phe Arg Glu Gly Pro Val Glu Ile
Gly Leu305 310 315 320Pro Cys Ser Thr Lys Asn Glu Thr Arg Pro Pro
Cys Val Pro Thr Pro 325 330 335Gly Lys Arg Glu Pro Gln Gly Ile Ser
Trp Asp Ser Pro Leu Asp Gly 340 345 350Ser Asn Lys Ser Ala Gly Pro
Pro Glu Pro Glu Val Ser Met Arg Arg 355 360 365Thr Ser Leu Gln Leu
Lys Leu Lys Ile Asp Asp Phe Ile Leu His Lys 370 375 380Met Leu Gly
Lys Gly Ser Phe Gly Lys Val Phe Leu Ala Glu Phe Lys385 390 395
400Arg Thr Asn Gln Phe Phe Ala Ile Lys Ala Leu Lys Lys Asp Val Val
405 410 415Leu Met Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg
Val Leu 420 425 430Ser Leu Ala Trp Glu His Pro Phe Leu Thr His Met
Phe Cys Thr Phe 435 440 445Gln Thr Lys Glu Asn Leu Phe Phe Val Met
Glu Tyr Leu Asn Gly Gly 450 455 460Asp Leu Met Tyr His Ile Gln Ser
Cys His Lys Phe Asp Leu Ser Arg465 470 475 480Ala Thr Phe Tyr Ala
Ala Glu Val Ile Leu Gly Leu Gln Phe Leu His 485 490 495Ser Lys Gly
Ile Val Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu 500 505 510Asp
Arg Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu 515 520
525Asn Met Leu Gly Asp Ala Lys Thr Asn Thr Phe Cys Gly Thr Pro Asp
530 535 540Tyr Ile Ala Pro Glu Ile Leu Leu Gly Gln Lys Tyr Asn His
Ser Val545 550 555 560Asp Trp Trp Ser Phe Gly Val Leu Val Tyr Glu
Met Leu Ile Gly Gln 565 570 575Ser Pro Phe His Gly Gln Asp Glu Glu
Glu Leu Phe His Ser Ile Arg 580 585 590Met Asp Asn Pro Phe Tyr Pro
Arg Trp Leu Glu Arg Glu Ala Lys Asp 595 600 605Leu Leu Val Lys Leu
Phe Val Arg Glu Pro Glu Lys Arg Leu Gly Val 610 615 620Arg Gly Asp
Ile Arg Gln His Pro Leu Phe Arg Glu Ile Asn Trp Glu625 630 635
640Glu Leu Glu Arg Lys Glu Ile Asp Pro Pro Phe Arg Pro Lys Val Lys
645 650 655Ser Pro Tyr Asp Cys Ser Asn Phe Asp Lys Glu Phe Leu Ser
Glu Lys 660 665 670Pro Arg Leu Ser Phe Ala Asp Arg Ala Leu Ile Asn
Ser Met Asp Gln 675 680 685Asn Met Phe Ser Asn Phe Ser Phe Ile Asn
Pro Gly Met Glu Thr Leu 690 695 700Ile Cys Ser7051319RNAArtificial
Sequencesynthetic oligonucleotide 13ccagagagag gaagccgaa
191419RNAArtificial Sequencesynthetic oligonucleotide 14aggaagagau
ggcucguca 191519RNAArtificial Sequencesynthetic oligonucleotide
15gucuugaccu ugaacggaa 191619RNAArtificial Sequencesynthetic
oligonucleotide 16aagcaggagu caaacgagu 191713PRTArtificial
Sequencesynthetic oligopeptide 17Ile Gly Val Ser Arg Gly Ser Gly
Gly Ala Glu Gly Lys1 5 10
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