U.S. patent application number 17/304557 was filed with the patent office on 2021-10-14 for stabilized human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using same. The applicant listed for this patent is Beth Israel Deaconess Medical Center, Inc.. Invention is credited to Dan H. Barouch, Joseph Patrick Nkolola.
Application Number | 20210317169 17/304557 |
Document ID | / |
Family ID | 1000005681449 |
Filed Date | 2021-10-14 |
United States Patent Application | 20210317169 |
Kind Code | A1 |
Barouch; Dan H. ; et al. | October 14, 2021 |
The invention features stabilized human immunodeficiency virus (HIV) envelope (Env) trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized HIV Env trimers. In addition, the invention features methods of making and using the stabilized HIV Env trimers of the invention.
Inventors: | Barouch; Dan H.; (Newton, MA) ; Nkolola; Joseph Patrick; (Watertown, MA) | ||||||||||
Applicant: |
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Family ID: | 1000005681449 | ||||||||||
Appl. No.: | 17/304557 | ||||||||||
Filed: | June 23, 2021 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
16177573 | Nov 1, 2018 | 11059863 | ||
17304557 | ||||
15897554 | Feb 15, 2018 | 10160788 | ||
16177573 | ||||
14149549 | Jan 7, 2014 | 9932370 | ||
15897554 | ||||
61749737 | Jan 7, 2013 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | A61K 2039/55566 20130101; C07K 14/005 20130101; A61K 39/12 20130101; C12N 2740/16111 20130101; A61K 39/21 20130101; A61K 2039/55561 20130101; C12N 2740/16122 20130101; C12N 2740/16134 20130101; A61K 2039/55505 20130101; C07K 14/162 20130101; C12N 2740/16034 20130101 |
International Class: | C07K 14/005 20060101 C07K014/005; A61K 39/21 20060101 A61K039/21; C07K 14/16 20060101 C07K014/16; A61K 39/12 20060101 A61K039/12 |
Sequence CWU 1
1
321712PRTArtificial SequenceSynthetic Construct (Mosaic gp140 Env1)
1Met Arg Val Thr Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp1 5
10 15Gly Thr Met Leu Leu Gly Ile Leu Met Ile Cys Ser Ala Ala Gly
Lys 20 25 30Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu
Ala Thr 35 40 45Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp
Thr Glu Val 50 55 60His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr
Asp Pro Asn Pro65 70 75 80Gln Glu Val Val Leu Glu Asn Val Thr Glu
Asn Phe Asn Met Trp Lys 85 90 95Asn Asn Met Val Glu Gln Met His Glu
Asp Ile Ile Ser Leu Trp Asp 100 105 110Gln Ser Leu Lys Pro Cys Val
Lys Leu Thr Pro Leu Cys Val Thr Leu 115 120 125Asn Cys Thr Asp Asp
Val Arg Asn Val Thr Asn Asn Ala Thr Asn Thr 130 135 140Asn Ser Ser
Trp Gly Glu Pro Met Glu Lys Gly Glu Ile Lys Asn Cys145 150 155
160Ser Phe Asn Ile Thr Thr Ser Ile Arg Asn Lys Val Gln Lys Gln Tyr
165 170 175Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp
Ser Asn 180 185 190Asn Thr Asn Tyr Arg Leu Ile Ser Cys Asn Thr Ser
Val Ile Thr Gln 195 200 205Ala Cys Pro Lys Val Ser Phe Glu Pro Ile
Pro Ile His Tyr Cys Ala 210 215 220Pro Ala Gly Phe Ala Ile Leu Lys
Cys Asn Asp Lys Lys Phe Asn Gly225 230 235 240Thr Gly Pro Cys Thr
Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 245 250 255Arg Pro Val
Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 260 265 270Glu
Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr 275 280
285Ile Met Val Gln Leu Asn Val Ser Val Glu Ile Asn Cys Thr Arg Pro
290 295 300Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg
Ala Phe305 310 315 320Tyr Thr Ala Gly Asp Ile Ile Gly Asp Ile Arg
Gln Ala His Cys Asn 325 330 335Ile Ser Arg Ala Asn Trp Asn Asn Thr
Leu Arg Gln Ile Val Glu Lys 340 345 350Leu Gly Lys Gln Phe Gly Asn
Asn Lys Thr Ile Val Phe Asn His Ser 355 360 365Ser Gly Gly Asp Pro
Glu Ile Val Met His Ser Phe Asn Cys Gly Gly 370 375 380Glu Phe Phe
Tyr Cys Asn Ser Thr Lys Leu Phe Asn Ser Thr Trp Thr385 390 395
400Trp Asn Asn Ser Thr Trp Asn Asn Thr Lys Arg Ser Asn Asp Thr Glu
405 410 415Glu His Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn
Met Trp 420 425 430Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile
Arg Gly Gln Ile 435 440 445Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu
Leu Thr Arg Asp Gly Gly 450 455 460Asn Asp Thr Ser Gly Thr Glu Ile
Phe Arg Pro Gly Gly Gly Asp Met465 470 475 480Arg Asp Asn Trp Arg
Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 485 490 495Glu Pro Leu
Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln 500 505 510Ser
Glu Lys Ser Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 515 520
525Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val
530 535 540Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn
Asn Leu545 550 555 560Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu
Gln Leu Thr Val Trp 565 570 575Gly Ile Lys Gln Leu Gln Ala Arg Val
Leu Ala Val Glu Arg Tyr Leu 580 585 590Lys Asp Gln Gln Leu Leu Gly
Ile Trp Gly Cys Ser Gly Lys Leu Ile 595 600 605Cys Thr Thr Thr Val
Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu 610 615 620Asp Lys Ile
Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile625 630 635
640Asn Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn
645 650 655Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys
Trp Ala 660 665 670Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu
Trp Gly Tyr Ile 675 680 685Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr
Val Arg Lys Asp Gly Glu 690 695 700Trp Val Leu Leu Ser Thr Phe
Leu705 7102724PRTArtificial SequenceSynthetic Construct (Optimized
mosaic gp140 Env1) 2Met Arg Val Arg Gly Ile Gln Arg Asn Cys Gln His
Leu Trp Arg Trp1 5 10 15Gly Thr Leu Ile Leu Gly Met Leu Met Ile Cys
Ser Ala Ala Gly Lys 20 25 30Leu Trp Val Thr Val Tyr Tyr Gly Val Pro
Val Trp Lys Glu Ala Thr 35 40 45Thr Thr Leu Phe Cys Ala Ser Asp Ala
Lys Ala Tyr Asp Thr Glu Val 50 55 60His Asn Val Trp Ala Thr His Ala
Cys Val Pro Thr Asp Pro Asn Pro65 70 75 80Gln Glu Val Val Leu Glu
Asn Val Thr Glu Asn Phe Asn Met Trp Lys 85 90 95Asn Asn Met Val Glu
Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 100 105 110Gln Ser Leu
Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 115 120 125Asn
Cys Thr Asp Asp Val Arg Asn Val Thr Asn Asn Ala Thr Asn Thr 130 135
140Asn Ser Ser Trp Gly Glu Pro Met Glu Lys Gly Glu Ile Lys Asn
Cys145 150 155 160Ser Phe Asn Ile Thr Thr Ser Ile Arg Asn Lys Val
Gln Lys Gln Tyr 165 170 175Ala Leu Phe Tyr Lys Leu Asp Val Val Pro
Ile Asp Asn Asp Ser Asn 180 185 190Asn Thr Asn Tyr Arg Leu Ile Ser
Cys Asn Thr Ser Val Ile Thr Gln 195 200 205Ala Cys Pro Lys Val Ser
Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 210 215 220Pro Ala Gly Phe
Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly225 230 235 240Thr
Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 245 250
255Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu
260 265 270Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala
Lys Thr 275 280 285Ile Met Val Gln Leu Asn Val Ser Val Glu Ile Asn
Cys Thr Arg Pro 290 295 300Asn Asn Asn Thr Arg Lys Ser Ile His Ile
Gly Pro Gly Arg Ala Phe305 310 315 320Tyr Thr Ala Gly Asp Ile Ile
Gly Asp Ile Arg Gln Ala His Cys Asn 325 330 335Ile Ser Arg Ala Asn
Trp Asn Asn Thr Leu Arg Gln Ile Val Glu Lys 340 345 350Leu Gly Lys
Gln Phe Gly Asn Asn Lys Thr Ile Val Phe Asn His Ser 355 360 365Ser
Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly 370 375
380Glu Phe Phe Tyr Cys Asn Ser Thr Lys Leu Phe Asn Ser Thr Trp
Thr385 390 395 400Trp Asn Asn Ser Thr Trp Asn Asn Thr Lys Arg Ser
Asn Asp Thr Glu 405 410 415Glu His Ile Thr Leu Pro Cys Arg Ile Lys
Gln Ile Ile Asn Met Trp 420 425 430Gln Glu Val Gly Lys Ala Met Tyr
Ala Pro Pro Ile Arg Gly Gln Ile 435 440 445Arg Cys Ser Ser Asn Ile
Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 450 455 460Asn Asp Thr Ser
Gly Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met465 470 475 480Arg
Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 485 490
495Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Glu Arg Val Val Gln
500 505 510Arg Glu Glu Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly
Phe Leu 515 520 525Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met
Thr Leu Thr Val 530 535 540Gln Ala Arg Leu Leu Leu Ser Gly Ile Val
Gln Gln Gln Asn Asn Leu545 550 555 560Leu Arg Ala Ile Glu Ala Gln
Gln His Leu Leu Gln Leu Thr Val Trp 565 570 575Gly Ile Lys Gln Leu
Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 580 585 590Lys Asp Gln
Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 595 600 605Cys
Thr Thr Thr Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu 610 615
620Asp Lys Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg Glu
Ile625 630 635 640Asn Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu
Glu Ser Gln Asn 645 650 655Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu
Glu Leu Asp Lys Trp Ala 660 665 670Ser Leu Trp Asn Trp Phe Asp Ile
Ser Asn Trp Leu Trp Tyr Ile Lys 675 680 685Ser Arg Ile Glu Gly Arg
Gly Ser Gly Gly Tyr Ile Pro Glu Ala Pro 690 695 700Arg Asp Gly Gln
Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu705 710 715 720Ser
Thr Phe Leu3708PRTArtificial SequenceSynthetic Construct (Optimized
clade C gp140 Env) 3Met Arg Val Arg Gly Ile Gln Arg Asn Cys Gln His
Leu Trp Arg Trp1 5 10 15Gly Thr Leu Ile Leu Gly Met Leu Met Ile Cys
Ser Ala Ala Glu Asn 20 25 30Leu Trp Val Gly Asn Met Trp Val Thr Val
Tyr Tyr Gly Val Pro Val 35 40 45Trp Thr Asp Ala Lys Thr Thr Leu Phe
Cys Ala Ser Asp Thr Lys Ala 50 55 60Tyr Asp Arg Glu Val His Asn Val
Trp Ala Thr His Ala Cys Val Pro65 70 75 80Thr Asp Pro Asn Pro Gln
Glu Ile Val Leu Glu Asn Val Thr Glu Asn 85 90 95Phe Asn Met Trp Lys
Asn Asp Met Val Asp Gln Met His Glu Asp Ile 100 105 110Ile Ser Leu
Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 115 120 125Leu
Cys Val Thr Leu His Cys Thr Asn Ala Thr Phe Lys Asn Asn Val 130 135
140Thr Asn Asp Met Asn Lys Glu Ile Arg Asn Cys Ser Phe Asn Thr
Thr145 150 155 160Thr Glu Ile Arg Asp Lys Lys Gln Gln Gly Tyr Ala
Leu Phe Tyr Arg 165 170 175Pro Asp Ile Val Leu Leu Lys Glu Asn Arg
Asn Asn Ser Asn Asn Ser 180 185 190Glu Tyr Ile Leu Ile Asn Cys Asn
Ala Ser Thr Ile Thr Gln Ala Cys 195 200 205Pro Lys Val Asn Phe Asp
Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 210 215 220Gly Tyr Ala Ile
Leu Lys Cys Asn Asn Lys Thr Phe Ser Gly Lys Gly225 230 235 240Pro
Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 245 250
255Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Glu
260 265 270Ile Ile Ile Arg Ser Glu Asn Leu Thr Asp Asn Val Lys Thr
Ile Ile 275 280 285Val His Leu Asn Lys Ser Val Glu Ile Val Cys Thr
Arg Pro Asn Asn 290 295 300Asn Thr Arg Lys Ser Met Arg Ile Gly Pro
Gly Gln Thr Phe Tyr Ala305 310 315 320Thr Gly Asp Ile Ile Gly Asp
Ile Arg Gln Ala Tyr Cys Asn Ile Ser 325 330 335Gly Ser Lys Trp Asn
Glu Thr Leu Lys Arg Val Lys Glu Lys Leu Gln 340 345 350Glu Asn Tyr
Asn Asn Asn Lys Thr Ile Lys Phe Ala Pro Ser Ser Gly 355 360 365Gly
Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe 370 375
380Phe Tyr Cys Asn Thr Thr Arg Leu Phe Asn Asn Asn Ala Thr Glu
Asp385 390 395 400Glu Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile
Ile Asn Met Trp 405 410 415Gln Gly Val Gly Arg Ala Met Tyr Ala Pro
Pro Ile Ala Gly Asn Ile 420 425 430Thr Cys Lys Ser Asn Ile Thr Gly
Leu Leu Leu Val Arg Asp Gly Gly 435 440 445Glu Asp Asn Lys Thr Glu
Glu Ile Phe Arg Pro Gly Gly Gly Asn Met 450 455 460Lys Asp Asn Trp
Arg Ser Glu Leu Tyr Lys Tyr Lys Val Ile Glu Leu465 470 475 480Lys
Pro Leu Gly Ile Ala Pro Thr Gly Ala Lys Glu Arg Val Val Glu 485 490
495Arg Glu Glu Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu
500 505 510Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu Thr Leu
Thr Val 515 520 525Gln Ala Arg Gln Leu Leu Ser Ser Ile Val Gln Gln
Gln Ser Asn Leu 530 535 540Leu Arg Ala Ile Glu Ala Gln Gln His Met
Leu Gln Leu Thr Val Trp545 550 555 560Gly Ile Lys Gln Leu Gln Thr
Arg Val Leu Ala Ile Glu Arg Tyr Leu 565 570 575Lys Asp Gln Gln Leu
Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 580 585 590Cys Thr Thr
Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln 595 600 605Thr
Asp Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile 610 615
620Ser Asn Tyr Thr Asp Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln
Thr625 630 635 640Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu
Asp Ser Trp Lys 645 650 655Asn Leu Trp Ser Trp Phe Asp Ile Ser Asn
Trp Leu Trp Tyr Ile Lys 660 665 670Ser Arg Ile Glu Gly Arg Gly Ser
Gly Gly Tyr Ile Pro Glu Ala Pro 675 680 685Arg Asp Gly Gln Ala Tyr
Val Arg Lys Asp Gly Glu Trp Val Leu Leu 690 695 700Ser Thr Phe
Leu7054684PRTArtificial SequenceSynthetic Construct (Mosaic gp140
Env2) 4Met Arg Val Arg Gly Ile Gln Arg Asn Trp Pro Gln Trp Trp Ile
Trp1 5 10 15Gly Ile Leu Gly Phe Trp Met Ile Ile Ile Cys Arg Val Met
Gly Asn 20 25 30Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys
Glu Ala Lys 35 40 45Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr
Glu Lys Glu Val 50 55 60His Asn Val Trp Ala Thr His Ala Cys Val Pro
Thr Asp Pro Asn Pro65 70 75 80Gln Glu Met Val Leu Glu Asn Val Thr
Glu Asn Phe Asn Met Trp Lys 85 90 95Asn Asp Met Val Asp Gln Met His
Glu Asp Ile Ile Arg Leu Trp Asp 100 105 110Gln Ser Leu Lys Pro Cys
Val Lys Leu Thr Pro Leu Cys Val Thr Leu 115 120 125Glu Cys Arg Asn
Val Arg Asn Val Ser Ser Asn Gly Thr Tyr Asn Ile 130 135 140Ile His
Asn Glu Thr Tyr Lys Glu Met Lys Asn Cys Ser Phe Asn Ala145 150 155
160Thr Thr Val Val Glu Asp Arg Lys Gln Lys Val His Ala Leu Phe Tyr
165 170 175Arg Leu Asp Ile Val Pro Leu Asp Glu Asn Asn Ser Ser Glu
Lys Ser 180 185 190Ser Glu Asn Ser Ser Glu Tyr Tyr Arg Leu Ile Asn
Cys Asn Thr Ser 195 200 205Ala Ile Thr Gln Ala Cys Pro Lys Val Ser
Phe Asp Pro Ile Pro Ile 210 215 220His Tyr Cys Ala Pro Ala Gly Tyr
Ala Ile Leu Lys Cys Asn Asn Lys225 230 235 240Thr Phe Asn Gly Thr
Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys 245 250 255Thr His Gly
Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 260 265 270Ser
Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn 275 280
285Asn Ala Lys Thr Ile Ile Val His Leu Asn Glu Thr Val Asn Ile Thr
290
295 300Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly
Pro305 310 315 320Gly Gln Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly
Asp Ile Arg Gln 325 330 335Ala His Cys Asn Leu Ser Arg Asp Gly Trp
Asn Lys Thr Leu Gln Gly 340 345 350Val Lys Lys Lys Leu Ala Glu His
Phe Pro Asn Lys Thr Ile Asn Phe 355 360 365Thr Ser Ser Ser Gly Gly
Asp Leu Glu Ile Thr Thr His Ser Phe Asn 370 375 380Cys Arg Gly Glu
Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Gly385 390 395 400Thr
Tyr Met Pro Asn Gly Thr Asn Ser Asn Ser Ser Ser Asn Ile Thr 405 410
415Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly
420 425 430Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys
Arg Ser 435 440 445Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly
Ser Asn Asn Gly 450 455 460Val Pro Asn Asp Thr Glu Thr Phe Arg Pro
Gly Gly Gly Asp Met Arg465 470 475 480Asn Asn Trp Arg Ser Glu Leu
Tyr Lys Tyr Lys Val Val Glu Val Lys 485 490 495Pro Leu Gly Val Ala
Pro Thr Glu Ala Lys Arg Arg Val Val Glu Ser 500 505 510Glu Lys Ser
Ala Val Gly Ile Gly Ala Val Phe Leu Gly Ile Leu Gly 515 520 525Ala
Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 530 535
540Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu
Leu545 550 555 560Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu
Thr Val Trp Gly 565 570 575Ile Lys Gln Leu Gln Thr Arg Val Leu Ala
Ile Glu Arg Tyr Leu Gln 580 585 590Asp Gln Gln Leu Leu Gly Leu Trp
Gly Cys Ser Gly Lys Leu Ile Cys 595 600 605Thr Thr Ala Val Pro Trp
Asn Thr Ser Trp Ser Asn Lys Ser Gln Thr 610 615 620Asp Ile Trp Asp
Asn Met Thr Trp Met Gln Trp Asp Lys Glu Ile Gly625 630 635 640Asn
Tyr Thr Gly Glu Ile Tyr Arg Leu Leu Glu Glu Ser Gln Asn Gln 645 650
655Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn
660 665 670Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp 675
6805678PRTArtificial SequenceSynthetic Construct (Mos3 gp140 Env)
5Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Lys Trp1 5
10 15Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu
Gln 20 25 30Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp
Ala Glu 35 40 45Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu
Arg Glu Val 50 55 60His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr
Asp Pro Asn Pro65 70 75 80Gln Glu Ile Val Leu Glu Asn Val Thr Glu
Glu Phe Asn Met Trp Lys 85 90 95Asn Asp Met Val Glu Gln Met His Thr
Asp Ile Ile Ser Leu Trp Asp 100 105 110Glu Ser Leu Lys Pro Cys Val
Lys Leu Ala Pro Leu Cys Val Thr Leu 115 120 125Asn Cys Thr Asn Ala
Asn Leu Asn Cys Thr Asn Asp Asn Cys Asn Arg 130 135 140Thr Val Asp
Lys Met Arg Glu Glu Ile Lys Asn Cys Ser Phe Asn Met145 150 155
160Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val Tyr Ala Leu Phe Tyr
165 170 175Lys Leu Asp Ile Val Pro Ile Glu Lys Asn Ser Ser Glu Tyr
Arg Leu 180 185 190Ile Asn Cys Asn Thr Ser Thr Ile Thr Gln Ala Cys
Pro Lys Val Thr 195 200 205Phe Glu Pro Ile Pro Ile His Tyr Cys Thr
Pro Ala Gly Phe Ala Ile 210 215 220Leu Lys Cys Lys Asp Lys Lys Phe
Asn Gly Thr Gly Pro Cys Lys Asn225 230 235 240Val Ser Thr Val Gln
Cys Thr His Gly Ile Lys Pro Val Ile Ser Thr 245 250 255Gln Leu Leu
Leu Asn Gly Ser Leu Ala Glu Gly Glu Ile Ile Ile Arg 260 265 270Ser
Glu Asn Ile Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asn 275 280
285Glu Ser Val Val Ile Asn Cys Thr Arg Pro Gly Asn Asn Thr Arg Lys
290 295 300Ser Val Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly
Glu Ile305 310 315 320Ile Gly Asp Ile Arg Gln Ala Tyr Cys Asn Ile
Ser Arg Ala Lys Trp 325 330 335Asn Asn Thr Leu Lys Gln Ile Val Thr
Lys Leu Lys Glu Gln Phe Lys 340 345 350Asn Lys Thr Ile Val Phe Asn
Gln Ser Ser Gly Gly Asp Pro Glu Ile 355 360 365Thr Thr His Ser Phe
Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr 370 375 380Thr Gln Leu
Phe Asn Ser Thr Trp Asn Ser Asn Ser Thr Trp Asn Asp385 390 395
400Thr Thr Gly Ser Val Thr Glu Gly Asn Asp Thr Ile Thr Leu Pro Cys
405 410 415Arg Ile Lys Gln Ile Val Asn Met Trp Gln Arg Val Gly Gln
Ala Met 420 425 430Tyr Ala Pro Pro Ile Glu Gly Asn Ile Thr Cys Lys
Ser Asn Ile Thr 435 440 445Gly Leu Leu Leu Val Arg Asp Gly Gly Asn
Ile Asn Arg Thr Asn Glu 450 455 460Thr Phe Arg Pro Gly Gly Gly Asn
Met Lys Asp Asn Trp Arg Ser Glu465 470 475 480Leu Tyr Lys Tyr Lys
Val Val Glu Ile Lys Pro Leu Gly Val Ala Pro 485 490 495Thr Arg Ala
Lys Arg Arg Val Val Glu Ser Glu Lys Ser Ala Val Gly 500 505 510Leu
Gly Ala Val Phe Leu Gly Phe Leu Gly Thr Ala Gly Ser Thr Met 515 520
525Gly Ala Ala Ser Leu Thr Leu Thr Val Gln Ala Arg Gln Val Leu Ser
530 535 540Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Lys Ala Ile Glu
Ala Gln545 550 555 560Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile
Lys Gln Leu Gln Ala 565 570 575Arg Ile Leu Ala Val Glu Arg Tyr Leu
Arg Asp Gln Gln Leu Leu Gly 580 585 590Ile Trp Gly Cys Ser Gly Lys
Leu Ile Cys Thr Thr Asn Val Pro Trp 595 600 605Asn Ser Ser Trp Ser
Asn Lys Ser Gln Glu Glu Ile Trp Asn Asn Met 610 615 620Thr Trp Met
Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asp Thr Ile625 630 635
640Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln
645 650 655Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp
Phe Ser 660 665 670Ile Thr Asn Trp Leu Trp 6756685PRTArtificial
SequenceSynthetic Construct (Mosaic gp140 Env1) 6Met Arg Val Thr
Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp1 5 10 15Gly Thr Met
Leu Leu Gly Ile Leu Met Ile Cys Ser Ala Ala Gly Lys 20 25 30Leu Trp
Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 35 40 45Thr
Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 50 55
60His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro65
70 75 80Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp
Lys 85 90 95Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu
Trp Asp 100 105 110Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu
Cys Val Thr Leu 115 120 125Asn Cys Thr Asp Asp Val Arg Asn Val Thr
Asn Asn Ala Thr Asn Thr 130 135 140Asn Ser Ser Trp Gly Glu Pro Met
Glu Lys Gly Glu Ile Lys Asn Cys145 150 155 160Ser Phe Asn Ile Thr
Thr Ser Ile Arg Asn Lys Val Gln Lys Gln Tyr 165 170 175Ala Leu Phe
Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Ser Asn 180 185 190Asn
Thr Asn Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln 195 200
205Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala
210 215 220Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe
Asn Gly225 230 235 240Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln
Cys Thr His Gly Ile 245 250 255Arg Pro Val Val Ser Thr Gln Leu Leu
Leu Asn Gly Ser Leu Ala Glu 260 265 270Glu Glu Val Val Ile Arg Ser
Glu Asn Phe Thr Asn Asn Ala Lys Thr 275 280 285Ile Met Val Gln Leu
Asn Val Ser Val Glu Ile Asn Cys Thr Arg Pro 290 295 300Asn Asn Asn
Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg Ala Phe305 310 315
320Tyr Thr Ala Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn
325 330 335Ile Ser Arg Ala Asn Trp Asn Asn Thr Leu Arg Gln Ile Val
Glu Lys 340 345 350Leu Gly Lys Gln Phe Gly Asn Asn Lys Thr Ile Val
Phe Asn His Ser 355 360 365Ser Gly Gly Asp Pro Glu Ile Val Met His
Ser Phe Asn Cys Gly Gly 370 375 380Glu Phe Phe Tyr Cys Asn Ser Thr
Lys Leu Phe Asn Ser Thr Trp Thr385 390 395 400Trp Asn Asn Ser Thr
Trp Asn Asn Thr Lys Arg Ser Asn Asp Thr Glu 405 410 415Glu His Ile
Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 420 425 430Gln
Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile 435 440
445Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly
450 455 460Asn Asp Thr Ser Gly Thr Glu Ile Phe Arg Pro Gly Gly Gly
Asp Met465 470 475 480Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr
Lys Val Val Lys Ile 485 490 495Glu Pro Leu Gly Val Ala Pro Thr Lys
Ala Lys Arg Arg Val Val Gln 500 505 510Ser Glu Lys Ser Ala Val Gly
Ile Gly Ala Val Phe Leu Gly Phe Leu 515 520 525Gly Ala Ala Gly Ser
Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val 530 535 540Gln Ala Arg
Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu545 550 555
560Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
565 570 575Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg
Tyr Leu 580 585 590Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser
Gly Lys Leu Ile 595 600 605Cys Thr Thr Thr Val Pro Trp Asn Ala Ser
Trp Ser Asn Lys Ser Leu 610 615 620Asp Lys Ile Trp Asn Asn Met Thr
Trp Met Glu Trp Glu Arg Glu Ile625 630 635 640Asn Asn Tyr Thr Ser
Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn 645 650 655Gln Gln Glu
Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala 660 665 670Ser
Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp 675 680
68571350PRTArtificial SequenceSynthetic Construct (Mosaic gagpol1
v3) 7Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg
Trp1 5 10 15Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg
Leu Lys 20 25 30His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala
Val Asn Pro 35 40 45Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile
Leu Gly Gln Leu 50 55 60Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu
Arg Ser Leu Tyr Asn65 70 75 80Thr Val Ala Thr Leu Tyr Cys Val His
Gln Arg Ile Glu Ile Lys Asp 85 90 95Thr Lys Glu Ala Leu Glu Lys Ile
Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110Lys Lys Ala Gln Gln Ala
Ala Ala Asp Thr Gly Asn Ser Ser Gln Val 115 120 125Ser Gln Asn Tyr
Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 130 135 140Gln Ala
Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu145 150 155
160Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser
165 170 175Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr
Val Gly 180 185 190Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr
Ile Asn Glu Glu 195 200 205Ala Ala Glu Trp Asp Arg Val His Pro Val
His Ala Gly Pro Ile Ala 210 215 220Pro Gly Gln Met Arg Glu Pro Arg
Gly Ser Asp Ile Ala Gly Thr Thr225 230 235 240Ser Thr Leu Gln Glu
Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250 255Pro Val Gly
Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270Ile
Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly 275 280
285Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu
290 295 300Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr
Glu Thr305 310 315 320Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys
Thr Ile Leu Lys Ala 325 330 335Leu Gly Pro Ala Ala Thr Leu Glu Glu
Met Met Thr Ala Cys Gln Gly 340 345 350Val Gly Gly Pro Gly His Lys
Ala Arg Val Leu Ala Glu Ala Met Ser 355 360 365Gln Val Thr Asn Ser
Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 370 375 380Asn Gln Arg
Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His385 390 395
400Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys
405 410 415Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln
Ala Asn 420 425 430Phe Leu Gly Lys Ile Trp Pro Ser Asn Lys Gly Arg
Pro Gly Asn Phe 435 440 445Leu Gln Asn Arg Pro Glu Pro Thr Ala Pro
Pro Glu Glu Ser Phe Arg 450 455 460Phe Gly Glu Glu Thr Thr Thr Pro
Ser Gln Lys Gln Glu Pro Ile Asp465 470 475 480Lys Glu Met Tyr Pro
Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp 485 490 495Pro Ser Ser
Gln Met Ala Pro Ile Ser Pro Ile Glu Thr Val Pro Val 500 505 510Lys
Leu Lys Pro Gly Met Asp Gly Pro Arg Val Lys Gln Trp Pro Leu 515 520
525Thr Glu Glu Lys Ile Lys Ala Leu Thr Ala Ile Cys Glu Glu Met Glu
530 535 540Lys Glu Gly Lys Ile Thr Lys Ile Gly Pro Glu Asn Pro Tyr
Asn Thr545 550 555 560Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr
Lys Trp Arg Lys Leu 565 570 575Val Asp Phe Arg Glu Leu Asn Lys Arg
Thr Gln Asp Phe Trp Glu Val 580 585 590Gln Leu Gly Ile Pro His Pro
Ala Gly Leu Lys Lys Lys Lys Ser Val 595 600 605Thr Val Leu Ala Val
Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu 610 615 620Gly Phe Arg
Lys Tyr Thr Ala Phe Thr Ile Pro Ser Thr Asn Asn Glu625 630 635
640Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys
645 650 655Gly Ser Pro Ala Ile Phe Gln Cys Ser Met Thr Arg Ile Leu
Glu Pro 660 665 670Phe Arg Ala Lys Asn Pro Glu Ile Val Ile Tyr Gln
Tyr Met Ala Ala 675 680 685Leu Tyr Val Gly Ser Asp Leu Glu Ile
Gly Gln His Arg Ala Lys Ile 690 695 700Glu Glu Leu Arg Glu His Leu
Leu Lys Trp Gly Phe Thr Thr Pro Asp705 710 715 720Lys Lys His Gln
Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu 725 730 735His Pro
Asp Lys Trp Thr Val Gln Pro Ile Gln Leu Pro Glu Lys Asp 740 745
750Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp
755 760 765Ala Ser Gln Ile Tyr Pro Gly Ile Lys Val Arg Gln Leu Cys
Lys Leu 770 775 780Leu Arg Gly Ala Lys Ala Leu Thr Asp Ile Val Pro
Leu Thr Glu Glu785 790 795 800Ala Glu Leu Glu Leu Ala Glu Asn Arg
Glu Ile Leu Lys Glu Pro Val 805 810 815His Gly Val Tyr Tyr Asp Pro
Ser Lys Asp Leu Ile Ala Glu Ile Gln 820 825 830Lys Gln Gly His Asp
Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe 835 840 845Lys Asn Leu
Lys Thr Gly Lys Tyr Ala Lys Met Arg Thr Ala His Thr 850 855 860Asn
Asp Val Lys Gln Leu Thr Glu Ala Val Gln Lys Ile Ala Met Glu865 870
875 880Ser Ile Val Ile Trp Gly Lys Thr Pro Lys Phe Arg Leu Pro Ile
Gln 885 890 895Lys Glu Thr Trp Glu Thr Trp Trp Thr Asp Tyr Trp Gln
Ala Thr Trp 900 905 910Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro
Leu Val Lys Leu Trp 915 920 925Tyr Gln Leu Glu Lys Asp Pro Ile Ala
Gly Val Glu Thr Phe Tyr Val 930 935 940Ala Gly Ala Ala Asn Arg Glu
Thr Lys Leu Gly Lys Ala Gly Tyr Val945 950 955 960Thr Asp Arg Gly
Arg Gln Lys Ile Val Ser Leu Thr Glu Thr Thr Asn 965 970 975Gln Lys
Thr Ala Leu Gln Ala Ile Tyr Leu Ala Leu Gln Asp Ser Gly 980 985
990Ser Glu Val Asn Ile Val Thr Ala Ser Gln Tyr Ala Leu Gly Ile Ile
995 1000 1005Gln Ala Gln Pro Asp Lys Ser Glu Ser Glu Leu Val Asn
Gln Ile 1010 1015 1020Ile Glu Gln Leu Ile Lys Lys Glu Arg Val Tyr
Leu Ser Trp Val 1025 1030 1035Pro Ala His Lys Gly Ile Gly Gly Asn
Glu Gln Val Asp Lys Leu 1040 1045 1050Val Ser Ser Gly Ile Arg Lys
Val Leu Phe Leu Asp Gly Ile Asp 1055 1060 1065Lys Ala Gln Glu Glu
His Glu Lys Tyr His Ser Asn Trp Arg Ala 1070 1075 1080Met Ala Ser
Asp Phe Asn Leu Pro Pro Val Val Ala Lys Glu Ile 1085 1090 1095Val
Ala Ser Cys Asp Gln Cys Gln Leu Lys Gly Glu Ala Met His 1100 1105
1110Gly Gln Val Asp Cys Ser Pro Gly Ile Trp Gln Leu Ala Cys Thr
1115 1120 1125His Leu Glu Gly Lys Ile Ile Leu Val Ala Val His Val
Ala Ser 1130 1135 1140Gly Tyr Ile Glu Ala Glu Val Ile Pro Ala Glu
Thr Gly Gln Glu 1145 1150 1155Thr Ala Tyr Phe Ile Leu Lys Leu Ala
Gly Arg Trp Pro Val Lys 1160 1165 1170Val Ile His Thr Ala Asn Gly
Ser Asn Phe Thr Ser Ala Ala Val 1175 1180 1185Lys Ala Ala Cys Trp
Trp Ala Gly Ile Gln Gln Glu Phe Gly Ile 1190 1195 1200Pro Tyr Asn
Pro Gln Ser Gln Gly Val Val Ala Ser Met Asn Lys 1205 1210 1215Glu
Leu Lys Lys Ile Ile Gly Gln Val Arg Asp Gln Ala Glu His 1220 1225
1230Leu Lys Thr Ala Val Gln Met Ala Val Phe Ile His Asn Phe Lys
1235 1240 1245Arg Lys Gly Gly Ile Gly Gly Tyr Ser Ala Gly Glu Arg
Ile Ile 1250 1255 1260Asp Ile Ile Ala Thr Asp Ile Gln Thr Lys Glu
Leu Gln Lys Gln 1265 1270 1275Ile Ile Lys Ile Gln Asn Phe Arg Val
Tyr Tyr Arg Asp Ser Arg 1280 1285 1290Asp Pro Ile Trp Lys Gly Pro
Ala Lys Leu Leu Trp Lys Gly Glu 1295 1300 1305Gly Ala Val Val Ile
Gln Asp Asn Ser Asp Ile Lys Val Val Pro 1310 1315 1320Arg Arg Lys
Val Lys Ile Ile Lys Asp Tyr Gly Lys Gln Met Ala 1325 1330 1335Gly
Ala Asp Cys Val Ala Gly Arg Gln Asp Glu Asp 1340 1345
13508857PRTArtificial SequenceSynthetic Construct (Mosaic gp160
Env1) 8Met Arg Val Thr Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg
Trp1 5 10 15Gly Thr Met Leu Leu Gly Ile Leu Met Ile Cys Ser Ala Ala
Gly Lys 20 25 30Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys
Glu Ala Thr 35 40 45Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr
Asp Thr Glu Val 50 55 60His Asn Val Trp Ala Thr His Ala Cys Val Pro
Thr Asp Pro Asn Pro65 70 75 80Gln Glu Val Val Leu Glu Asn Val Thr
Glu Asn Phe Asn Met Trp Lys 85 90 95Asn Asn Met Val Glu Gln Met His
Glu Asp Ile Ile Ser Leu Trp Asp 100 105 110Gln Ser Leu Lys Pro Cys
Val Lys Leu Thr Pro Leu Cys Val Thr Leu 115 120 125Asn Cys Thr Asp
Asp Val Arg Asn Val Thr Asn Asn Ala Thr Asn Thr 130 135 140Asn Ser
Ser Trp Gly Glu Pro Met Glu Lys Gly Glu Ile Lys Asn Cys145 150 155
160Ser Phe Asn Ile Thr Thr Ser Ile Arg Asn Lys Val Gln Lys Gln Tyr
165 170 175Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp
Ser Asn 180 185 190Asn Thr Asn Tyr Arg Leu Ile Ser Cys Asn Thr Ser
Val Ile Thr Gln 195 200 205Ala Cys Pro Lys Val Ser Phe Glu Pro Ile
Pro Ile His Tyr Cys Ala 210 215 220Pro Ala Gly Phe Ala Ile Leu Lys
Cys Asn Asp Lys Lys Phe Asn Gly225 230 235 240Thr Gly Pro Cys Thr
Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 245 250 255Arg Pro Val
Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 260 265 270Glu
Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr 275 280
285Ile Met Val Gln Leu Asn Val Ser Val Glu Ile Asn Cys Thr Arg Pro
290 295 300Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg
Ala Phe305 310 315 320Tyr Thr Ala Gly Asp Ile Ile Gly Asp Ile Arg
Gln Ala His Cys Asn 325 330 335Ile Ser Arg Ala Asn Trp Asn Asn Thr
Leu Arg Gln Ile Val Glu Lys 340 345 350Leu Gly Lys Gln Phe Gly Asn
Asn Lys Thr Ile Val Phe Asn His Ser 355 360 365Ser Gly Gly Asp Pro
Glu Ile Val Met His Ser Phe Asn Cys Gly Gly 370 375 380Glu Phe Phe
Tyr Cys Asn Ser Thr Lys Leu Phe Asn Ser Thr Trp Thr385 390 395
400Trp Asn Asn Ser Thr Trp Asn Asn Thr Lys Arg Ser Asn Asp Thr Glu
405 410 415Glu His Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn
Met Trp 420 425 430Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile
Arg Gly Gln Ile 435 440 445Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu
Leu Thr Arg Asp Gly Gly 450 455 460Asn Asp Thr Ser Gly Thr Glu Ile
Phe Arg Pro Gly Gly Gly Asp Met465 470 475 480Arg Asp Asn Trp Arg
Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 485 490 495Glu Pro Leu
Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln 500 505 510Arg
Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 515 520
525Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val
530 535 540Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn
Asn Leu545 550 555 560Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu
Gln Leu Thr Val Trp 565 570 575Gly Ile Lys Gln Leu Gln Ala Arg Val
Leu Ala Val Glu Arg Tyr Leu 580 585 590Lys Asp Gln Gln Leu Leu Gly
Ile Trp Gly Cys Ser Gly Lys Leu Ile 595 600 605Cys Thr Thr Thr Val
Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu 610 615 620Asp Lys Ile
Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile625 630 635
640Asn Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn
645 650 655Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys
Trp Ala 660 665 670Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu
Trp Tyr Ile Lys 675 680 685Ile Phe Ile Met Ile Val Gly Gly Leu Val
Gly Leu Arg Ile Val Phe 690 695 700Ala Val Leu Ser Ile Val Asn Arg
Val Arg Gln Gly Tyr Ser Pro Leu705 710 715 720Ser Phe Gln Thr Arg
Leu Pro Ala Pro Arg Gly Pro Asp Arg Pro Glu 725 730 735Gly Ile Glu
Glu Glu Gly Gly Glu Arg Asp Arg Asp Arg Ser Val Arg 740 745 750Leu
Val Asp Gly Phe Leu Val Leu Ile Trp Asp Asp Leu Gln Ser Leu 755 760
765Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Val Glu
770 775 780Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp
Asn Leu785 790 795 800Leu Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser
Ala Ile Ser Leu Leu 805 810 815Asn Ala Thr Ala Val Ala Val Ala Glu
Gly Thr Asp Arg Val Ile Glu 820 825 830Ala Leu Gln Arg Ala Cys Arg
Ala Ile Leu His Ile Pro Arg Arg Ile 835 840 845Arg Gln Gly Leu Glu
Arg Leu Leu Leu 850 8559867PRTArtificial SequenceSynthetic
Construct (Mosaic gp160 Env2) 9Met Arg Val Arg Gly Ile Gln Arg Asn
Trp Pro Gln Trp Trp Ile Trp1 5 10 15Gly Ile Leu Gly Phe Trp Met Ile
Ile Ile Cys Arg Val Met Gly Asn 20 25 30Leu Trp Val Thr Val Tyr Tyr
Gly Val Pro Val Trp Lys Glu Ala Lys 35 40 45Thr Thr Leu Phe Cys Ala
Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 50 55 60His Asn Val Trp Ala
Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro65 70 75 80Gln Glu Met
Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 85 90 95Asn Asp
Met Val Asp Gln Met His Glu Asp Ile Ile Arg Leu Trp Asp 100 105
110Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu
115 120 125Glu Cys Arg Asn Val Arg Asn Val Ser Ser Asn Gly Thr Tyr
Asn Ile 130 135 140Ile His Asn Glu Thr Tyr Lys Glu Met Lys Asn Cys
Ser Phe Asn Ala145 150 155 160Thr Thr Val Val Glu Asp Arg Lys Gln
Lys Val His Ala Leu Phe Tyr 165 170 175Arg Leu Asp Ile Val Pro Leu
Asp Glu Asn Asn Ser Ser Glu Lys Ser 180 185 190Ser Glu Asn Ser Ser
Glu Tyr Tyr Arg Leu Ile Asn Cys Asn Thr Ser 195 200 205Ala Ile Thr
Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile 210 215 220His
Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys225 230
235 240Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln
Cys 245 250 255Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu
Leu Asn Gly 260 265 270Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser
Glu Asn Leu Thr Asn 275 280 285Asn Ala Lys Thr Ile Ile Val His Leu
Asn Glu Thr Val Asn Ile Thr 290 295 300Cys Thr Arg Pro Asn Asn Asn
Thr Arg Lys Ser Ile Arg Ile Gly Pro305 310 315 320Gly Gln Thr Phe
Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 325 330 335Ala His
Cys Asn Leu Ser Arg Asp Gly Trp Asn Lys Thr Leu Gln Gly 340 345
350Val Lys Lys Lys Leu Ala Glu His Phe Pro Asn Lys Thr Ile Asn Phe
355 360 365Thr Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser
Phe Asn 370 375 380Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly
Leu Phe Asn Gly385 390 395 400Thr Tyr Met Pro Asn Gly Thr Asn Ser
Asn Ser Ser Ser Asn Ile Thr 405 410 415Leu Pro Cys Arg Ile Lys Gln
Ile Ile Asn Met Trp Gln Glu Val Gly 420 425 430Arg Ala Met Tyr Ala
Pro Pro Ile Ala Gly Asn Ile Thr Cys Arg Ser 435 440 445Asn Ile Thr
Gly Leu Leu Leu Thr Arg Asp Gly Gly Ser Asn Asn Gly 450 455 460Val
Pro Asn Asp Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg465 470
475 480Asn Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Val
Lys 485 490 495Pro Leu Gly Val Ala Pro Thr Glu Ala Lys Arg Arg Val
Val Glu Arg 500 505 510Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe
Leu Gly Ile Leu Gly 515 520 525Ala Ala Gly Ser Thr Met Gly Ala Ala
Ser Ile Thr Leu Thr Val Gln 530 535 540Ala Arg Gln Leu Leu Ser Gly
Ile Val Gln Gln Gln Ser Asn Leu Leu545 550 555 560Arg Ala Ile Glu
Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 565 570 575Ile Lys
Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Gln 580 585
590Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys
595 600 605Thr Thr Ala Val Pro Trp Asn Thr Ser Trp Ser Asn Lys Ser
Gln Thr 610 615 620Asp Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp
Lys Glu Ile Gly625 630 635 640Asn Tyr Thr Gly Glu Ile Tyr Arg Leu
Leu Glu Glu Ser Gln Asn Gln 645 650 655Gln Glu Lys Asn Glu Lys Asp
Leu Leu Ala Leu Asp Ser Trp Lys Asn 660 665 670Leu Trp Asn Trp Phe
Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile 675 680 685Phe Ile Met
Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Leu Gly 690 695 700Val
Leu Ser Ile Val Arg Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser705 710
715 720Phe Gln Thr Leu Thr Pro Asn Pro Arg Gly Leu Asp Arg Leu Gly
Arg 725 730 735Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser
Ile Arg Leu 740 745 750Val Asn Gly Phe Leu Ala Leu Ala Trp Asp Asp
Leu Arg Ser Leu Cys 755 760 765Leu Phe Ser Tyr His Gln Leu Arg Asp
Phe Ile Leu Ile Val Ala Arg 770 775 780Ala Val Glu Leu Leu Gly Arg
Ser Ser Leu Arg Gly Leu Gln Arg Gly785 790 795 800Trp Glu Ala Leu
Lys Tyr Leu Gly Asn Leu Val Gln Tyr Trp Gly Leu 805 810 815Glu Leu
Lys Lys Gly Ala Ile Ser Leu Leu Asp Thr Ile Ala Ile Ala 820 825
830Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu Ile Gln Ser Ile Cys
835 840 845Arg Ala Ile Arg Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe
Glu Ala 850 855 860Ser Leu Leu86510500PRTArtificial
SequenceSynthetic Construct (Mosaic gag1) 10Met Gly Ala Arg Ala Ser
Val Leu Ser Gly Gly Glu Leu Asp Arg Trp1 5 10 15Glu Lys Ile Arg Leu
Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys 20 25 30His Ile Val Trp
Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45Gly Leu Leu
Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55
60Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn65
70 75 80Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys
Asp 85 90 95Thr Lys Glu Ala Leu Glu Lys Ile Glu Glu Glu Gln Asn Lys
Ser Lys 100 105 110Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn
Ser Ser Gln Val 115 120 125Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile
Gln Gly Gln Met Val His 130 135 140Gln Ala Ile Ser Pro Arg Thr Leu
Asn Ala Trp Val Lys Val Val Glu145 150 155 160Glu Lys Ala Phe Ser
Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175Glu Gly Ala
Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190Gly
His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200
205Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala
210 215 220Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly
Thr Thr225 230 235 240Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr
Asn Asn Pro Pro Ile 245 250 255Pro Val Gly Glu Ile Tyr Lys Arg Trp
Ile Ile Leu Gly Leu Asn Lys 260 265 270Ile Val Arg Met Tyr Ser Pro
Val Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285Pro Lys Glu Pro Phe
Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300Arg Ala Glu
Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr305 310 315
320Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala
325 330 335Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys
Gln Gly 340 345 350Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala
Glu Ala Met Ser 355 360 365Gln Val Thr Asn Ser Ala Thr Ile Met Met
Gln Arg Gly Asn Phe Arg 370 375 380Asn Gln Arg Lys Thr Val Lys Cys
Phe Asn Cys Gly Lys Glu Gly His385 390 395 400Ile Ala Lys Asn Cys
Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 405 410 415Gly Lys Glu
Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 420 425 430Phe
Leu Gly Lys Ile Trp Pro Ser Asn Lys Gly Arg Pro Gly Asn Phe 435 440
445Leu Gln Asn Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg
450 455 460Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro
Ile Asp465 470 475 480Lys Glu Met Tyr Pro Leu Ala Ser Leu Lys Ser
Leu Phe Gly Asn Asp 485 490 495Pro Ser Ser Gln
50011491PRTArtificial SequenceSynthetic Construct (Mosaic gag2)
11Met Gly Ala Arg Ala Ser Ile Leu Arg Gly Gly Lys Leu Asp Lys Trp1
5 10 15Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys His Tyr Met Leu
Lys 20 25 30His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu
Asn Pro 35 40 45Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile
Lys Gln Leu 50 55 60Gln Pro Ala Leu Gln Thr Gly Thr Glu Glu Leu Arg
Ser Leu Phe Asn65 70 75 80Thr Val Ala Thr Leu Tyr Cys Val His Ala
Glu Ile Glu Val Arg Asp 85 90 95Thr Lys Glu Ala Leu Asp Lys Ile Glu
Glu Glu Gln Asn Lys Ser Gln 100 105 110Gln Lys Thr Gln Gln Ala Lys
Glu Ala Asp Gly Lys Val Ser Gln Asn 115 120 125Tyr Pro Ile Val Gln
Asn Leu Gln Gly Gln Met Val His Gln Pro Ile 130 135 140Ser Pro Arg
Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu Lys Ala145 150 155
160Phe Ser Pro Glu Val Ile Pro Met Phe Thr Ala Leu Ser Glu Gly Ala
165 170 175Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly
His Gln 180 185 190Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu
Glu Ala Ala Glu 195 200 205Trp Asp Arg Leu His Pro Val His Ala Gly
Pro Val Ala Pro Gly Gln 210 215 220Met Arg Glu Pro Arg Gly Ser Asp
Ile Ala Gly Thr Thr Ser Asn Leu225 230 235 240Gln Glu Gln Ile Ala
Trp Met Thr Ser Asn Pro Pro Ile Pro Val Gly 245 250 255Asp Ile Tyr
Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg 260 265 270Met
Tyr Ser Pro Thr Ser Ile Leu Asp Ile Lys Gln Gly Pro Lys Glu 275 280
285Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg Ala Glu
290 295 300Gln Ala Thr Gln Asp Val Lys Asn Trp Met Thr Asp Thr Leu
Leu Val305 310 315 320Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu
Arg Ala Leu Gly Pro 325 330 335Gly Ala Thr Leu Glu Glu Met Met Thr
Ala Cys Gln Gly Val Gly Gly 340 345 350Pro Ser His Lys Ala Arg Val
Leu Ala Glu Ala Met Ser Gln Thr Asn 355 360 365Ser Thr Ile Leu Met
Gln Arg Ser Asn Phe Lys Gly Ser Lys Arg Ile 370 375 380Val Lys Cys
Phe Asn Cys Gly Lys Glu Gly His Ile Ala Arg Asn Cys385 390 395
400Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys Glu Gly His
405 410 415Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly
Lys Ile 420 425 430Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu
Gln Ser Arg Pro 435 440 445Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe
Arg Phe Glu Glu Thr Thr 450 455 460Pro Ala Pro Lys Gln Glu Pro Lys
Asp Arg Glu Pro Leu Thr Ser Leu465 470 475 480Arg Ser Leu Phe Gly
Ser Asp Pro Leu Ser Gln 485 49012999PRTArtificial SequenceSynthetic
Construct (Mosaic pol1) 12Phe Phe Arg Glu Asn Leu Ala Phe Gln Gln
Gly Glu Ala Arg Glu Phe1 5 10 15Pro Ser Glu Gln Thr Arg Ala Asn Ser
Pro Thr Ser Arg Glu Leu Gln 20 25 30Val Arg Gly Asp Asn Pro His Ser
Glu Ala Gly Ala Glu Arg Gln Gly 35 40 45Thr Leu Asn Phe Pro Gln Ile
Thr Leu Trp Gln Arg Pro Leu Val Ser 50 55 60Ile Lys Val Gly Gly Gln
Ile Arg Glu Ala Leu Leu Asp Thr Gly Ala65 70 75 80Asp Asp Thr Val
Leu Glu Asp Ile Asn Leu Pro Gly Lys Trp Lys Pro 85 90 95Lys Met Ile
Gly Gly Ile Gly Gly Phe Ile Lys Val Arg Gln Tyr Asp 100 105 110Gln
Ile Leu Ile Glu Ile Cys Gly Lys Lys Ala Ile Gly Thr Val Leu 115 120
125Val Gly Pro Thr Pro Val Asn Ile Ile Gly Arg Asn Met Leu Thr Gln
130 135 140Leu Gly Cys Thr Leu Asn Phe Pro Ile Ser Pro Ile Glu Thr
Val Pro145 150 155 160Val Lys Leu Lys Pro Gly Met Asp Gly Pro Arg
Val Lys Gln Trp Pro 165 170 175Leu Thr Glu Glu Lys Ile Lys Ala Leu
Thr Ala Ile Cys Glu Glu Met 180 185 190Glu Lys Glu Gly Lys Ile Thr
Lys Ile Gly Pro Glu Asn Pro Tyr Asn 195 200 205Thr Pro Val Phe Ala
Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys 210 215 220Leu Val Asp
Phe Arg Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu225 230 235
240Val Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys Lys Lys Lys Ser
245 250 255Val Thr Val Leu Asp Val Gly Asp Ala Tyr Phe Ser Val Pro
Leu Asp 260 265 270Glu Gly Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro
Ser Thr Asn Asn 275 280 285Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn
Val Leu Pro Gln Gly Trp 290 295 300Lys Gly Ser Pro Ala Ile Phe Gln
Cys Ser Met Thr Arg Ile Leu Glu305 310 315 320Pro Phe Arg Ala Lys
Asn Pro Glu Ile Val Ile Tyr Gln Tyr Met Asp 325 330 335Asp Leu Tyr
Val Gly Ser Asp Leu Glu Ile Gly Gln His Arg Ala Lys 340 345 350Ile
Glu Glu Leu Arg Glu His Leu Leu Lys Trp Gly Phe Thr Thr Pro 355 360
365Asp Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu
370 375 380Leu His Pro Asp Lys Trp Thr Val Gln Pro Ile Gln Leu Pro
Glu Lys385 390 395 400Asp Ser Trp Thr Val Asn Asp Ile Gln Lys Leu
Val Gly Lys Leu Asn 405 410 415Trp Ala Ser Gln Ile Tyr Pro Gly Ile
Lys Val Arg Gln Leu Cys Lys 420 425 430Leu Leu Arg Gly Ala Lys Ala
Leu Thr Asp Ile Val Pro Leu Thr Glu 435 440 445Glu Ala Glu Leu Glu
Leu Ala Glu Asn Arg Glu Ile Leu Lys Glu Pro 450 455 460Val His Gly
Val Tyr Tyr Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile465 470 475
480Gln Lys Gln Gly His Asp Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro
485 490 495Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala Lys Met Arg Thr
Ala His 500 505 510Thr Asn Asp Val Lys Gln Leu Thr Glu Ala Val Gln
Lys Ile Ala Met 515 520 525Glu Ser Ile Val Ile Trp Gly Lys Thr Pro
Lys Phe Arg Leu Pro Ile 530 535 540Gln Lys Glu Thr Trp Glu Thr Trp
Trp Thr Asp Tyr Trp Gln Ala Thr545 550 555 560Trp Ile Pro Glu Trp
Glu Phe Val Asn Thr Pro Pro Leu Val Lys Leu 565 570 575Trp Tyr Gln
Leu Glu Lys Asp Pro Ile Ala Gly Val Glu Thr Phe Tyr 580 585 590Val
Asp Gly Ala Ala Asn Arg Glu Thr Lys Leu Gly Lys Ala Gly Tyr 595 600
605Val Thr Asp Arg Gly Arg Gln Lys Ile Val Ser Leu Thr Glu Thr Thr
610 615 620Asn Gln Lys Thr Glu Leu Gln Ala Ile Tyr Leu Ala Leu Gln
Asp Ser625 630 635 640Gly Ser Glu Val Asn Ile Val Thr Asp Ser Gln
Tyr Ala Leu Gly Ile 645 650 655Ile Gln Ala Gln Pro Asp Lys Ser Glu
Ser Glu Leu Val Asn Gln Ile 660 665 670Ile Glu Gln Leu Ile Lys Lys
Glu Arg Val Tyr Leu Ser Trp Val Pro 675 680 685Ala His Lys Gly Ile
Gly Gly Asn Glu Gln Val Asp Lys Leu Val Ser 690 695 700Ser Gly Ile
Arg Lys Val Leu Phe Leu Asp Gly Ile Asp Lys Ala Gln705 710 715
720Glu Glu His Glu Lys Tyr His Ser Asn Trp Arg Ala Met Ala Ser Asp
725 730 735Phe Asn Leu Pro Pro Val Val Ala Lys Glu Ile Val Ala Ser
Cys Asp 740 745 750Gln Cys Gln Leu Lys Gly Glu Ala Met His Gly Gln
Val Asp Cys Ser 755 760 765Pro Gly Ile Trp Gln Leu Asp Cys Thr His
Leu Glu Gly Lys Ile Ile 770 775 780Leu Val Ala Val His Val Ala Ser
Gly Tyr Ile Glu Ala Glu Val Ile785 790 795 800Pro Ala Glu Thr Gly
Gln Glu Thr Ala Tyr Phe Ile Leu Lys Leu Ala 805 810 815Gly Arg Trp
Pro Val Lys Val Ile His Thr Asp Asn Gly Ser Asn Phe 820 825 830Thr
Ser Ala Ala Val Lys Ala Ala Cys Trp Trp Ala Gly Ile Gln Gln 835 840
845Glu Phe Gly Ile Pro Tyr Asn Pro Gln Ser Gln Gly Val Val Glu Ser
850 855 860Met Asn Lys Glu Leu Lys Lys Ile Ile Gly Gln Val Arg Asp
Gln Ala865 870 875 880Glu His Leu Lys Thr Ala Val Gln Met Ala Val
Phe Ile His Asn Phe 885 890 895Lys Arg Lys Gly Gly Ile Gly Gly Tyr
Ser Ala Gly Glu Arg Ile Ile 900 905 910Asp Ile Ile Ala Thr Asp Ile
Gln Thr Lys Glu Leu Gln Lys Gln Ile 915 920 925Ile Lys Ile Gln Asn
Phe Arg Val Tyr Tyr Arg Asp Ser Arg Asp Pro 930 935 940Ile Trp Lys
Gly Pro Ala Lys Leu Leu Trp Lys Gly Glu Gly Ala Val945 950 955
960Val Ile Gln Asp Asn Ser Asp Ile Lys Val Val Pro Arg Arg Lys Val
965 970 975Lys Ile Ile Lys Asp Tyr Gly Lys Gln Met Ala Gly Ala Asp
Cys Val 980 985 990Ala Gly Arg Gln Asp Glu Asp
995131003PRTArtificial SequenceSynthetic Construct (Mosaic pol2)
13Phe Phe Arg Glu Asn Leu Ala Phe Pro Gln Gly Lys Ala Arg Glu Phe1
5 10 15Ser Ser Glu Gln Thr Arg Ala Asn Ser Pro Thr Arg Arg Glu Leu
Gln 20 25 30Val Trp Gly Arg Asp Asn Asn Ser Leu Ser Glu Ala Gly Ala
Asp Arg 35 40 45Gln Gly Thr Val Ser Phe Ser Phe Pro Gln Ile Thr Leu
Trp Gln Arg 50 55 60Pro Leu Val Thr Ile Lys Ile Gly Gly Gln Leu Lys
Glu Ala Leu Leu65 70 75 80Asp Thr Gly Ala Asp Asp Thr Val Leu Glu
Glu Met Asn Leu Pro Gly 85 90 95Arg Trp Lys Pro Lys Met Ile Gly Gly
Ile Gly Gly Phe Ile Lys Val 100 105 110Arg Gln Tyr Asp Gln Ile Pro
Ile Glu Ile Cys Gly His Lys Ala Ile 115 120 125Gly Thr Val Leu Val
Gly Pro Thr Pro Val Asn Ile Ile Gly Arg Asn 130 135 140Leu Leu Thr
Gln Ile Gly Cys Thr Leu Asn Phe Pro Ile Ser Pro Ile145 150 155
160Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly Pro Lys Val
165 170 175Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Val
Glu Ile 180 185 190Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys
Ile Gly Pro Glu 195 200 205Asn Pro Tyr Asn Thr Pro Ile Phe Ala Ile
Lys Lys Lys Asp Ser Thr 210 215 220Lys Trp Arg Lys Leu Val Asp Phe
Arg Glu Leu Asn Lys Arg Thr Gln225 230 235 240Asp Phe Trp Glu Val
Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys 245 250 255Lys Lys Lys
Ser Val Thr Val Leu Asp Val Gly Asp Ala Tyr Phe Ser 260 265 270Val
Pro Leu Asp Glu Asp Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro 275 280
285Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu
290 295 300Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Ser Ser
Met Thr305 310 315 320Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro
Asp Ile Val Ile Tyr 325 330 335Gln Tyr Met Asp Asp Leu Tyr Val Gly
Ser Asp Leu Glu Ile Gly Gln 340 345 350His Arg Thr Lys Ile Glu Glu
Leu Arg Gln His Leu Leu Arg Trp Gly 355 360 365Phe Thr Thr Pro Asp
Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp 370 375 380Met Gly Tyr
Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro Ile Val385 390 395
400Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val
405 410 415Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys
Val Lys 420 425 430Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu
Thr Glu Val Val 435 440 445Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu
Ala Glu Asn Arg Glu Ile 450 455 460Leu Lys Glu Pro Val His Gly Val
Tyr Tyr Asp Pro Ser Lys Asp Leu465 470 475 480Ile Ala Glu Ile Gln
Lys Gln Gly Gln Gly Gln Trp Thr Tyr Gln Ile 485 490 495Tyr Gln Glu
Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala Arg Met 500 505 510Arg
Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr
Glu Ala Val Gln 515 520 525Lys Ile Ala Thr Glu Ser Ile Val Ile Trp
Gly Lys Thr Pro Lys Phe 530 535 540Lys Leu Pro Ile Gln Lys Glu Thr
Trp Glu Ala Trp Trp Thr Glu Tyr545 550 555 560Trp Gln Ala Thr Trp
Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro 565 570 575Leu Val Lys
Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Val Gly Ala 580 585 590Glu
Thr Phe Tyr Val Asp Gly Ala Ala Asn Arg Glu Thr Lys Leu Gly 595 600
605Lys Ala Gly Tyr Val Thr Asp Arg Gly Arg Gln Lys Val Val Ser Leu
610 615 620Thr Asp Thr Thr Asn Gln Lys Thr Glu Leu Gln Ala Ile His
Leu Ala625 630 635 640Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val
Thr Asp Ser Gln Tyr 645 650 655Ala Leu Gly Ile Ile Gln Ala Gln Pro
Asp Lys Ser Glu Ser Glu Leu 660 665 670Val Ser Gln Ile Ile Glu Gln
Leu Ile Lys Lys Glu Lys Val Tyr Leu 675 680 685Ala Trp Val Pro Ala
His Lys Gly Ile Gly Gly Asn Glu Gln Val Asp 690 695 700Lys Leu Val
Ser Arg Gly Ile Arg Lys Val Leu Phe Leu Asp Gly Ile705 710 715
720Asp Lys Ala Gln Glu Glu His Glu Lys Tyr His Ser Asn Trp Arg Ala
725 730 735Met Ala Ser Glu Phe Asn Leu Pro Pro Ile Val Ala Lys Glu
Ile Val 740 745 750Ala Ser Cys Asp Lys Cys Gln Leu Lys Gly Glu Ala
Ile His Gly Gln 755 760 765Val Asp Cys Ser Pro Gly Ile Trp Gln Leu
Asp Cys Thr His Leu Glu 770 775 780Gly Lys Val Ile Leu Val Ala Val
His Val Ala Ser Gly Tyr Ile Glu785 790 795 800Ala Glu Val Ile Pro
Ala Glu Thr Gly Gln Glu Thr Ala Tyr Phe Leu 805 810 815Leu Lys Leu
Ala Gly Arg Trp Pro Val Lys Thr Ile His Thr Asp Asn 820 825 830Gly
Ser Asn Phe Thr Ser Ala Thr Val Lys Ala Ala Cys Trp Trp Ala 835 840
845Gly Ile Lys Gln Glu Phe Gly Ile Pro Tyr Asn Pro Gln Ser Gln Gly
850 855 860Val Val Glu Ser Ile Asn Lys Glu Leu Lys Lys Ile Ile Gly
Gln Val865 870 875 880Arg Asp Gln Ala Glu His Leu Lys Thr Ala Val
Gln Met Ala Val Phe 885 890 895Ile His Asn Phe Lys Arg Lys Gly Gly
Ile Gly Glu Tyr Ser Ala Gly 900 905 910Glu Arg Ile Val Asp Ile Ile
Ala Ser Asp Ile Gln Thr Lys Glu Leu 915 920 925Gln Lys Gln Ile Thr
Lys Ile Gln Asn Phe Arg Val Tyr Tyr Arg Asp 930 935 940Ser Arg Asp
Pro Leu Trp Lys Gly Pro Ala Lys Leu Leu Trp Lys Gly945 950 955
960Glu Gly Ala Val Val Ile Gln Asp Asn Ser Asp Ile Lys Val Val Pro
965 970 975Arg Arg Lys Ala Lys Ile Ile Arg Asp Tyr Gly Lys Gln Met
Ala Gly 980 985 990Asp Asp Cys Val Ala Ser Arg Gln Asp Glu Asp 995
100014206PRTArtificial SequenceSynthetic Construct (Mosaic nef1)
14Met Gly Gly Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Ile1
5 10 15Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly
Ala 20 25 30Val Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser
Asn Thr 35 40 45Ala Ala Asn Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln
Glu Glu Glu 50 55 60Glu Val Gly Phe Pro Val Arg Pro Gln Val Pro Leu
Arg Pro Met Thr65 70 75 80Tyr Lys Gly Ala Leu Asp Leu Ser His Phe
Leu Lys Glu Lys Gly Gly 85 90 95Leu Glu Gly Leu Ile Tyr Ser Gln Lys
Arg Gln Asp Ile Leu Asp Leu 100 105 110Trp Val Tyr His Thr Gln Gly
Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 115 120 125Pro Gly Pro Gly Ile
Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys 130 135 140Leu Val Pro
Val Glu Pro Glu Lys Ile Glu Glu Ala Asn Glu Gly Glu145 150 155
160Asn Asn Ser Leu Leu His Pro Met Ser Gln His Gly Met Asp Asp Pro
165 170 175Glu Lys Glu Val Leu Met Trp Lys Phe Asp Ser Arg Leu Ala
Phe His 180 185 190His Met Ala Arg Glu Leu His Pro Glu Tyr Tyr Lys
Asp Cys 195 200 20515206PRTArtificial SequenceSynthetic Construct
(Mosaic nef2) 15Met Gly Gly Lys Trp Ser Lys Ser Ser Ile Val Gly Trp
Pro Ala Val1 5 10 15Arg Glu Arg Ile Arg Arg Ala Glu Pro Ala Ala Glu
Gly Val Gly Ala 20 25 30Ala Ser Gln Asp Leu Asp Lys Tyr Gly Ala Leu
Thr Ser Ser Asn Thr 35 40 45Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu
Glu Ala Gln Glu Asp Glu 50 55 60Glu Val Gly Phe Pro Val Lys Pro Gln
Val Pro Leu Arg Pro Met Thr65 70 75 80Tyr Lys Ala Ala Phe Asp Leu
Ser Phe Phe Leu Lys Glu Lys Gly Gly 85 90 95Leu Asp Gly Leu Ile Tyr
Ser Lys Lys Arg Gln Glu Ile Leu Asp Leu 100 105 110Trp Val Tyr Asn
Thr Gln Gly Phe Phe Pro Asp Trp Gln Asn Tyr Thr 115 120 125Pro Gly
Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys 130 135
140Leu Val Pro Val Asp Pro Arg Glu Val Glu Glu Ala Asn Lys Gly
Glu145 150 155 160Asn Asn Cys Leu Leu His Pro Met Asn Leu His Gly
Met Asp Asp Pro 165 170 175Glu Arg Glu Val Leu Val Trp Arg Phe Asp
Ser Arg Leu Ala Phe His 180 185 190His Met Ala Arg Glu Lys His Pro
Glu Tyr Tyr Lys Asn Cys 195 200 20516850PRTArtificial
SequenceSynthetic Construct (Mosaic pol1) 16Met Ala Pro Ile Ser Pro
Ile Glu Thr Val Pro Val Lys Leu Lys Pro1 5 10 15Gly Met Asp Gly Pro
Arg Val Lys Gln Trp Pro Leu Thr Glu Glu Lys 20 25 30Ile Lys Ala Leu
Thr Ala Ile Cys Glu Glu Met Glu Lys Glu Gly Lys 35 40 45Ile Thr Lys
Ile Gly Pro Glu Asn Pro Tyr Asn Thr Pro Val Phe Ala 50 55 60Ile Lys
Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg65 70 75
80Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile
85 90 95Pro His Pro Ala Gly Leu Lys Lys Lys Lys Ser Val Thr Val Leu
Ala 100 105 110Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu Gly
Phe Arg Lys 115 120 125Tyr Thr Ala Phe Thr Ile Pro Ser Thr Asn Asn
Glu Thr Pro Gly Ile 130 135 140Arg Tyr Gln Tyr Asn Val Leu Pro Gln
Gly Trp Lys Gly Ser Pro Ala145 150 155 160Ile Phe Gln Cys Ser Met
Thr Arg Ile Leu Glu Pro Phe Arg Ala Lys 165 170 175Asn Pro Glu Ile
Val Ile Tyr Gln Tyr Met Ala Ala Leu Tyr Val Gly 180 185 190Ser Asp
Leu Glu Ile Gly Gln His Arg Ala Lys Ile Glu Glu Leu Arg 195 200
205Glu His Leu Leu Lys Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln
210 215 220Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu His Pro
Asp Lys225 230 235 240Trp Thr Val Gln Pro Ile Gln Leu Pro Glu Lys
Asp Ser Trp Thr Val 245 250 255Asn Asp Ile Gln Lys Leu Val Gly Lys
Leu Asn Trp Ala Ser Gln Ile 260 265 270Tyr Pro Gly Ile Lys Val Arg
Gln Leu Cys Lys Leu Leu Arg Gly Ala 275 280 285Lys Ala Leu Thr Asp
Ile Val Pro Leu Thr Glu Glu Ala Glu Leu Glu 290 295 300Leu Ala Glu
Asn Arg Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr305 310 315
320Tyr Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly His
325 330 335Asp Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe Lys Asn
Leu Lys 340 345 350Thr Gly Lys Tyr Ala Lys Met Arg Thr Ala His Thr
Asn Asp Val Lys 355 360 365Gln Leu Thr Glu Ala Val Gln Lys Ile Ala
Met Glu Ser Ile Val Ile 370 375 380Trp Gly Lys Thr Pro Lys Phe Arg
Leu Pro Ile Gln Lys Glu Thr Trp385 390 395 400Glu Thr Trp Trp Thr
Asp Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp 405 410 415Glu Phe Val
Asn Thr Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu 420 425 430Lys
Asp Pro Ile Ala Gly Val Glu Thr Phe Tyr Val Ala Gly Ala Ala 435 440
445Asn Arg Glu Thr Lys Leu Gly Lys Ala Gly Tyr Val Thr Asp Arg Gly
450 455 460Arg Gln Lys Ile Val Ser Leu Thr Glu Thr Thr Asn Gln Lys
Thr Ala465 470 475 480Leu Gln Ala Ile Tyr Leu Ala Leu Gln Asp Ser
Gly Ser Glu Val Asn 485 490 495Ile Val Thr Ala Ser Gln Tyr Ala Leu
Gly Ile Ile Gln Ala Gln Pro 500 505 510Asp Lys Ser Glu Ser Glu Leu
Val Asn Gln Ile Ile Glu Gln Leu Ile 515 520 525Lys Lys Glu Arg Val
Tyr Leu Ser Trp Val Pro Ala His Lys Gly Ile 530 535 540Gly Gly Asn
Glu Gln Val Asp Lys Leu Val Ser Ser Gly Ile Arg Lys545 550 555
560Val Leu Phe Leu Asp Gly Ile Asp Lys Ala Gln Glu Glu His Glu Lys
565 570 575Tyr His Ser Asn Trp Arg Ala Met Ala Ser Asp Phe Asn Leu
Pro Pro 580 585 590Val Val Ala Lys Glu Ile Val Ala Ser Cys Asp Gln
Cys Gln Leu Lys 595 600 605Gly Glu Ala Met His Gly Gln Val Asp Cys
Ser Pro Gly Ile Trp Gln 610 615 620Leu Ala Cys Thr His Leu Glu Gly
Lys Ile Ile Leu Val Ala Val His625 630 635 640Val Ala Ser Gly Tyr
Ile Glu Ala Glu Val Ile Pro Ala Glu Thr Gly 645 650 655Gln Glu Thr
Ala Tyr Phe Ile Leu Lys Leu Ala Gly Arg Trp Pro Val 660 665 670Lys
Val Ile His Thr Ala Asn Gly Ser Asn Phe Thr Ser Ala Ala Val 675 680
685Lys Ala Ala Cys Trp Trp Ala Gly Ile Gln Gln Glu Phe Gly Ile Pro
690 695 700Tyr Asn Pro Gln Ser Gln Gly Val Val Ala Ser Met Asn Lys
Glu Leu705 710 715 720Lys Lys Ile Ile Gly Gln Val Arg Asp Gln Ala
Glu His Leu Lys Thr 725 730 735Ala Val Gln Met Ala Val Phe Ile His
Asn Phe Lys Arg Lys Gly Gly 740 745 750Ile Gly Gly Tyr Ser Ala Gly
Glu Arg Ile Ile Asp Ile Ile Ala Thr 755 760 765Asp Ile Gln Thr Lys
Glu Leu Gln Lys Gln Ile Ile Lys Ile Gln Asn 770 775 780Phe Arg Val
Tyr Tyr Arg Asp Ser Arg Asp Pro Ile Trp Lys Gly Pro785 790 795
800Ala Lys Leu Leu Trp Lys Gly Glu Gly Ala Val Val Ile Gln Asp Asn
805 810 815Ser Asp Ile Lys Val Val Pro Arg Arg Lys Val Lys Ile Ile
Lys Asp 820 825 830Tyr Gly Lys Gln Met Ala Gly Ala Asp Cys Val Ala
Gly Arg Gln Asp 835 840 845Glu Asp 85017850PRTArtificial
SequenceSynthetic Construct (Mosaic pol1) 17Met Ala Pro Ile Ser Pro
Ile Glu Thr Val Pro Val Lys Leu Lys Pro1 5 10 15Gly Met Asp Gly Pro
Lys Val Lys Gln Trp Pro Leu Thr Glu Glu Lys 20 25 30Ile Lys Ala Leu
Val Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys 35 40 45Ile Ser Lys
Ile Gly Pro Glu Asn Pro Tyr Asn Thr Pro Ile Phe Ala 50 55 60Ile Lys
Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg65 70 75
80Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile
85 90 95Pro His Pro Ala Gly Leu Lys Lys Lys Lys Ser Val Thr Val Leu
Ala 100 105 110Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu Asp
Phe Arg Lys 115 120 125Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn Asn
Glu Thr Pro Gly Ile 130 135 140Arg Tyr Gln Tyr Asn Val Leu Pro Gln
Gly Trp Lys Gly Ser Pro Ala145 150 155 160Ile Phe Gln Ser Ser Met
Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln 165 170 175Asn Pro Asp Ile
Val Ile Tyr Gln Tyr Met Ala Ala Leu Tyr Val Gly 180 185 190Ser Asp
Leu Glu Ile Gly Gln His Arg Thr Lys Ile Glu Glu Leu Arg 195 200
205Gln His Leu Leu Arg Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln
210 215 220Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu His Pro
Asp Lys225 230 235 240Trp Thr Val Gln Pro Ile Val Leu Pro Glu Lys
Asp Ser Trp Thr Val 245 250 255Asn Asp Ile Gln Lys Leu Val Gly Lys
Leu Asn Trp Ala Ser Gln Ile 260 265 270Tyr Ala Gly Ile Lys Val Lys
Gln Leu Cys Lys Leu Leu Arg Gly Thr 275 280 285Lys Ala Leu Thr Glu
Val Val Pro Leu Thr Glu Glu Ala Glu Leu Glu 290 295 300Leu Ala Glu
Asn Arg Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr305 310 315
320Tyr Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly Gln
325 330 335Gly Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe Lys Asn
Leu Lys 340 345 350Thr Gly Lys Tyr Ala Arg Met Arg Gly Ala His Thr
Asn Asp Val Lys 355 360 365Gln Leu Thr Glu Ala Val Gln Lys Ile Ala
Thr Glu Ser Ile Val Ile 370 375 380Trp Gly Lys Thr Pro Lys Phe Lys
Leu Pro Ile Gln Lys Glu Thr Trp385 390 395 400Glu Ala Trp Trp Thr
Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp 405 410 415Glu Phe Val
Asn Thr Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu 420 425 430Lys
Glu Pro Ile Val Gly Ala Glu Thr Phe Tyr Val Ala Gly Ala Ala 435 440
445Asn Arg Glu Thr Lys Leu Gly Lys Ala Gly Tyr Val Thr Asp Arg Gly
450 455 460Arg Gln Lys Val Val Ser Leu Thr Asp Thr Thr Asn Gln Lys
Thr Ala465 470 475 480Leu Gln Ala Ile His Leu Ala Leu Gln Asp Ser
Gly Leu Glu Val Asn 485 490 495Ile Val Thr Ala Ser Gln Tyr Ala Leu
Gly Ile Ile Gln Ala Gln Pro 500 505 510Asp Lys Ser Glu Ser Glu Leu
Val Ser Gln Ile Ile Glu Gln Leu Ile 515 520 525Lys Lys Glu Lys Val
Tyr Leu Ala Trp Val Pro Ala His Lys Gly Ile 530 535 540Gly Gly Asn
Glu Gln Val Asp Lys Leu Val Ser Arg Gly Ile Arg Lys545 550 555
560Val Leu Phe Leu Asp Gly Ile Asp Lys Ala Gln Glu Glu His Glu Lys
565 570 575Tyr His Ser Asn Trp Arg Ala Met Ala Ser Glu Phe Asn Leu
Pro Pro 580 585 590Ile Val Ala Lys Glu Ile Val Ala Ser Cys Asp Lys
Cys Gln Leu Lys 595 600 605Gly Glu Ala Ile His Gly Gln Val Asp Cys
Ser Pro Gly Ile Trp Gln 610 615 620Leu Ala Cys Thr His Leu Glu Gly
Lys Val Ile Leu Val Ala Val His625 630 635 640Val Ala Ser Gly Tyr
Ile Glu Ala Glu Val Ile Pro Ala Glu Thr Gly 645 650 655Gln Glu Thr
Ala Tyr Phe Leu Leu Lys Leu Ala Gly Arg Trp Pro Val 660 665 670Lys
Thr Ile His Thr Ala Asn Gly Ser Asn Phe Thr Ser Ala Thr Val 675 680
685Lys Ala Ala Cys
Trp Trp Ala Gly Ile Lys Gln Glu Phe Gly Ile Pro 690 695 700Tyr Asn
Pro Gln Ser Gln Gly Val Val Ala Ser Ile Asn Lys Glu Leu705 710 715
720Lys Lys Ile Ile Gly Gln Val Arg Asp Gln Ala Glu His Leu Lys Thr
725 730 735Ala Val Gln Met Ala Val Phe Ile His Asn Phe Lys Arg Lys
Gly Gly 740 745 750Ile Gly Glu Tyr Ser Ala Gly Glu Arg Ile Val Asp
Ile Ile Ala Ser 755 760 765Asp Ile Gln Thr Lys Glu Leu Gln Lys Gln
Ile Thr Lys Ile Gln Asn 770 775 780Phe Arg Val Tyr Tyr Arg Asp Ser
Arg Asp Pro Leu Trp Lys Gly Pro785 790 795 800Ala Lys Leu Leu Trp
Lys Gly Glu Gly Ala Val Val Ile Gln Asp Asn 805 810 815Ser Asp Ile
Lys Val Val Pro Arg Arg Lys Ala Lys Ile Ile Arg Asp 820 825 830Tyr
Gly Lys Gln Met Ala Gly Asp Asp Cys Val Ala Ser Arg Gln Asp 835 840
845Glu Asp 85018851PRTArtificial SequenceSynthetic Construct (Mos3
pol v3) 18Met Ala Pro Ile Ser Pro Ile Asp Thr Val Pro Val Thr Leu
Lys Pro1 5 10 15Gly Met Asp Gly Pro Lys Ile Lys Gln Trp Pro Leu Thr
Glu Glu Lys 20 25 30Ile Lys Ala Leu Thr Glu Ile Cys Thr Glu Met Glu
Lys Glu Gly Lys 35 40 45Ile Ser Arg Ile Gly Pro Glu Asn Pro Tyr Asn
Thr Pro Val Phe Ala 50 55 60Ile Lys Lys Lys Asn Ser Thr Arg Trp Arg
Lys Leu Val Asp Phe Arg65 70 75 80Glu Leu Asn Lys Lys Thr Gln Asp
Phe Trp Glu Val Gln Leu Gly Ile 85 90 95Pro His Pro Ala Gly Leu Lys
Lys Lys Arg Ser Val Thr Val Leu Ala 100 105 110Val Gly Asp Ala Tyr
Phe Ser Val Pro Leu Asp Lys Asp Phe Arg Lys 115 120 125Tyr Thr Ala
Phe Thr Ile Pro Ser Val Asn Asn Glu Thr Pro Gly Val 130 135 140Arg
Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala145 150
155 160Ile Phe Gln Cys Ser Met Thr Lys Ile Leu Glu Pro Phe Arg Ala
Gln 165 170 175Asn Pro Glu Ile Val Ile Tyr Gln Tyr Val Ala Ala Leu
Tyr Val Gly 180 185 190Ser Asp Leu Glu Ile Glu Gln His Arg Thr Lys
Ile Glu Glu Leu Arg 195 200 205Ala His Leu Leu Ser Trp Gly Phe Thr
Thr Pro Asp Lys Lys His Gln 210 215 220Arg Glu Pro Pro Phe Leu Trp
Met Gly Tyr Glu Leu His Pro Asp Arg225 230 235 240Trp Thr Val Gln
Pro Ile Glu Leu Pro Glu Lys Glu Ser Trp Thr Val 245 250 255Asn Asp
Ile Gln Lys Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile 260 265
270Tyr Pro Gly Ile Lys Val Lys Gln Leu Cys Arg Leu Leu Arg Gly Ala
275 280 285Lys Ala Leu Thr Glu Val Ile Pro Leu Thr Lys Glu Ala Glu
Leu Glu 290 295 300Leu Ala Glu Asn Arg Glu Ile Leu Arg Glu Pro Val
His Gly Val Tyr305 310 315 320Tyr Asp Pro Ser Lys Asp Leu Val Ala
Glu Ile Gln Lys Gln Gly Gln 325 330 335Asp Gln Trp Thr Tyr Gln Ile
Tyr Gln Glu Pro Tyr Lys Asn Leu Lys 340 345 350Thr Gly Lys Tyr Ala
Arg Lys Arg Ser Ala His Thr Asn Asp Val Arg 355 360 365Gln Leu Thr
Glu Ala Val Gln Lys Ile Ala Leu Glu Ser Ile Val Ile 370 375 380Trp
Gly Lys Ile Pro Lys Phe Arg Leu Pro Ile Gln Arg Glu Thr Trp385 390
395 400Glu Thr Trp Trp Thr Glu Tyr Trp Gln Ala Thr Trp Ile Pro Asp
Trp 405 410 415Glu Phe Val Asn Thr Pro Pro Leu Val Lys Leu Trp Tyr
Gln Leu Glu 420 425 430Lys Glu Pro Ile Ala Gly Ala Glu Thr Phe Tyr
Val Ala Gly Ala Ser 435 440 445Asn Arg Glu Thr Lys Ile Gly Lys Ala
Gly Tyr Val Thr Asp Lys Gly 450 455 460Arg Gln Lys Val Val Ser Leu
Thr Glu Thr Thr Asn Gln Lys Ala Ala465 470 475 480Leu Gln Ala Ile
Gln Leu Ala Leu Gln Asp Ser Gly Pro Glu Val Asn 485 490 495Ile Val
Thr Ala Ser Gln Tyr Val Leu Gly Ile Ile Gln Ala Gln Pro 500 505
510Asp Arg Ser Glu Ser Glu Leu Val Asn Gln Ile Ile Glu Glu Leu Ile
515 520 525Lys Lys Glu Lys Val Tyr Leu Ser Trp Val Pro Ala His Lys
Gly Ile 530 535 540Gly Gly Asn Glu Gln Val Asp Lys Leu Val Ser Ala
Gly Ile Arg Lys545 550 555 560Ile Leu Phe Leu Asp Gly Ile Asp Lys
Ala Gln Glu Glu His Glu Arg 565 570 575Tyr His Ser Asn Trp Arg Thr
Met Ala Ser Asp Phe Asn Leu Pro Pro 580 585 590Ile Val Ala Lys Glu
Ile Val Ala Asn Cys Asp Lys Cys Gln Leu Lys 595 600 605Gly Glu Ala
Met His Gly Gln Val Asp Cys Ser Pro Gly Met Trp Gln 610 615 620Leu
Ala Cys Thr His Leu Glu Gly Lys Ile Ile Ile Val Ala Val His625 630
635 640Val Ala Ser Gly Tyr Met Glu Ala Glu Val Ile Pro Ala Glu Thr
Gly 645 650 655Gln Glu Thr Ala Tyr Tyr Ile Leu Lys Leu Ala Gly Arg
Trp Pro Val 660 665 670Lys Val Val His Thr Ala Asn Gly Ser Asn Phe
Thr Ser Thr Thr Val 675 680 685Lys Ala Ala Cys Trp Trp Ala Asn Val
Thr Gln Glu Phe Gly Ile Pro 690 695 700Tyr Asn Pro Gln Ser Gln Gly
Val Ile Ala Ser Met Asn Lys Glu Leu705 710 715 720Lys Lys Ile Ile
Gly Gln Val Arg Glu Gln Ala Glu His Leu Lys Thr 725 730 735Ala Val
Gln Met Ala Val Leu Ile His Asn Phe Lys Arg Arg Gly Gly 740 745
750Ile Gly Gly Tyr Ser Ala Gly Glu Arg Ile Val Asp Ile Ile Ala Thr
755 760 765Asp Ile Gln Thr Arg Glu Leu Gln Lys Gln Ile Ile Lys Ile
Gln Asn 770 775 780Phe Arg Val Tyr Phe Arg Asp Ser Arg Asp Pro Val
Trp Lys Gly Pro785 790 795 800Ala Lys Leu Leu Trp Lys Gly Glu Gly
Ala Val Val Ile Gln Asp Asn 805 810 815Ser Glu Ile Lys Val Val Pro
Arg Arg Lys Val Lys Ile Ile Arg Asp 820 825 830Tyr Gly Lys Gln Met
Ala Gly Asp Asp Cys Val Ala Gly Arg Gln Asp 835 840 845Glu Asp Gln
85019508PRTArtificial SequenceSynthetic Construct (Mos3 gag) 19Met
Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Lys Leu Asp Ala Trp1 5 10
15Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys
20 25 30His Ile Val Trp Ala Ser Arg Glu Leu Asp Arg Phe Ala Leu Asn
Pro 35 40 45Gly Leu Leu Glu Thr Ala Glu Gly Cys Gln Gln Ile Ile Glu
Gln Leu 50 55 60Gln Pro Ala Leu Gln Thr Gly Ser Glu Glu Leu Lys Ser
Leu Tyr Asn65 70 75 80Thr Val Ala Val Leu Tyr Cys Val His Gln Arg
Ile Asp Val Lys Asp 85 90 95Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu
Ile Gln Asn Lys Ser Lys 100 105 110Gln Lys Thr Gln Gln Ala Ala Ala
Asp Thr Gly Ser Ser Ser Lys Val 115 120 125Ser Gln Asn Tyr Pro Ile
Val Gln Asn Ala Gln Gly Gln Met Val His 130 135 140Gln Ala Leu Ser
Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu145 150 155 160Glu
Lys Gly Phe Asn Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ala 165 170
175Glu Gly Ala Thr Pro Gln Asp Leu Asn Met Met Leu Asn Ile Val Gly
180 185 190Gly His Gln Ala Ala Met Gln Ile Leu Lys Asp Thr Ile Asn
Glu Glu 195 200 205Ala Ala Asp Trp Asp Arg Leu His Pro Val His Ala
Gly Pro Ile Pro 210 215 220Pro Gly Gln Met Arg Glu Pro Arg Gly Ser
Asp Ile Ala Gly Thr Thr225 230 235 240Ser Thr Pro Gln Glu Gln Ile
Gly Trp Met Thr Ser Asn Pro Pro Val 245 250 255Pro Val Gly Glu Ile
Tyr Lys Arg Trp Ile Ile Met Gly Leu Asn Lys 260 265 270Ile Val Arg
Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Lys Gln Gly 275 280 285Pro
Lys Glu Ser Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Val Leu 290 295
300Arg Ala Glu Gln Ala Thr Gln Glu Val Lys Asn Trp Met Thr Glu
Thr305 310 315 320Leu Leu Ile Gln Asn Ala Asn Pro Asp Cys Lys Ser
Ile Leu Arg Ala 325 330 335Leu Gly Pro Gly Ala Ser Leu Glu Glu Met
Met Thr Ala Cys Gln Gly 340 345 350Val Gly Gly Pro Ser His Lys Ala
Arg Ile Leu Ala Glu Ala Met Ser 355 360 365Gln Ala Asn Asn Thr Asn
Ile Met Met Gln Arg Gly Asn Phe Lys Gly 370 375 380Gln Lys Arg Ile
Lys Cys Phe Asn Cys Gly Lys Glu Gly His Leu Ala385 390 395 400Arg
Asn Cys Arg Ala Pro Arg Lys Arg Gly Cys Trp Lys Cys Gly Arg 405 410
415Glu Gly His Gln Met Lys Asp Cys Asn Glu Arg Gln Ala Asn Phe Leu
420 425 430Gly Lys Ile Trp Pro Ser Ser Lys Gly Arg Pro Gly Asn Phe
Pro Gln 435 440 445Ser Arg Pro Glu Pro Thr Ala Pro Leu Glu Pro Thr
Ala Pro Pro Ala 450 455 460Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe
Gly Phe Gly Glu Glu Ile465 470 475 480Thr Pro Ser Pro Lys Gln Glu
Gln Lys Asp Arg Glu Pro Leu Thr Ser 485 490 495Leu Lys Ser Leu Phe
Gly Ser Asp Pro Leu Leu Gln 500 50520206PRTArtificial
SequenceSynthetic Construct ((Mos1 nef) (G to A to delete
myristylation site)) 20Met Ala Gly Lys Trp Ser Lys Ser Ser Val Val
Gly Trp Pro Ala Ile1 5 10 15Arg Glu Arg Met Arg Arg Ala Glu Pro Ala
Ala Asp Gly Val Gly Ala 20 25 30Val Ser Arg Asp Leu Glu Lys His Gly
Ala Ile Thr Ser Ser Asn Thr 35 40 45Ala Ala Asn Asn Ala Asp Cys Ala
Trp Leu Glu Ala Gln Glu Glu Glu 50 55 60Glu Val Gly Phe Pro Val Arg
Pro Gln Val Pro Leu Arg Pro Met Thr65 70 75 80Tyr Lys Gly Ala Leu
Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 85 90 95Leu Glu Gly Leu
Ile Tyr Ser Gln Lys Arg Gln Asp Ile Leu Asp Leu 100 105 110Trp Val
Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 115 120
125Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys
130 135 140Leu Val Pro Val Glu Pro Glu Lys Ile Glu Glu Ala Asn Glu
Gly Glu145 150 155 160Asn Asn Ser Leu Leu His Pro Met Ser Gln His
Gly Met Asp Asp Pro 165 170 175Glu Lys Glu Val Leu Met Trp Lys Phe
Asp Ser Arg Leu Ala Phe His 180 185 190His Met Ala Arg Glu Leu His
Pro Glu Tyr Tyr Lys Asp Cys 195 200 20521206PRTArtificial
SequenceSynthetic Construct ((Mos2 nef) (G to A to delete
myristylation)) 21Met Ala Gly Lys Trp Ser Lys Ser Ser Ile Val Gly
Trp Pro Ala Val1 5 10 15Arg Glu Arg Ile Arg Arg Ala Glu Pro Ala Ala
Glu Gly Val Gly Ala 20 25 30Ala Ser Gln Asp Leu Asp Lys Tyr Gly Ala
Leu Thr Ser Ser Asn Thr 35 40 45Ala Ala Thr Asn Ala Asp Cys Ala Trp
Leu Glu Ala Gln Glu Asp Glu 50 55 60Glu Val Gly Phe Pro Val Lys Pro
Gln Val Pro Leu Arg Pro Met Thr65 70 75 80Tyr Lys Ala Ala Phe Asp
Leu Ser Phe Phe Leu Lys Glu Lys Gly Gly 85 90 95Leu Asp Gly Leu Ile
Tyr Ser Lys Lys Arg Gln Glu Ile Leu Asp Leu 100 105 110Trp Val Tyr
Asn Thr Gln Gly Phe Phe Pro Asp Trp Gln Asn Tyr Thr 115 120 125Pro
Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys 130 135
140Leu Val Pro Val Asp Pro Arg Glu Val Glu Glu Ala Asn Lys Gly
Glu145 150 155 160Asn Asn Cys Leu Leu His Pro Met Asn Leu His Gly
Met Asp Asp Pro 165 170 175Glu Arg Glu Val Leu Val Trp Arg Phe Asp
Ser Arg Leu Ala Phe His 180 185 190His Met Ala Arg Glu Lys His Pro
Glu Tyr Tyr Lys Asn Cys 195 200 20522208PRTArtificial
SequenceSynthetic Construct (Mos3 nef) 22Met Ala Gly Lys Trp Ser
Lys Arg Ser Val Val Gly Trp Pro Ala Val1 5 10 15Arg Glu Arg Met Arg
Arg Thr Glu Pro Ala Ala Glu Gly Val Gly Ala 20 25 30Val Ser Gln Asp
Leu Asp Lys His Gly Ala Leu Thr Ser Ser Asn Thr 35 40 45Ala His Asn
Asn Ala Asp Cys Ala Trp Leu Gln Ala Gln Glu Glu Glu 50 55 60Glu Glu
Val Gly Phe Pro Val Arg Pro Gln Val Pro Val Arg Pro Met65 70 75
80Thr Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly
85 90 95Gly Leu Glu Gly Leu Ile His Ser Gln Lys Arg Gln Glu Ile Leu
Asp 100 105 110Leu Trp Val Tyr His Thr Gln Gly Phe Phe Pro Asp Trp
His Asn Tyr 115 120 125Thr Pro Gly Pro Gly Thr Arg Phe Pro Leu Thr
Phe Gly Trp Cys Tyr 130 135 140Lys Leu Val Pro Val Asp Pro Lys Glu
Val Glu Glu Ala Asn Glu Gly145 150 155 160Glu Asn Asn Cys Leu Leu
His Pro Met Ser Gln His Gly Met Glu Asp 165 170 175Glu Asp Arg Glu
Val Leu Lys Trp Lys Phe Asp Ser Ser Leu Ala Arg 180 185 190Arg His
Met Ala Arg Glu Leu His Pro Glu Phe Tyr Lys Asp Cys Leu 195 200
20523705PRTArtificial SequenceSynthetic Construct (Mosaic gagnef1)
23Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp1
5 10 15Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu
Lys 20 25 30His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val
Asn Pro 35 40 45Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu
Gly Gln Leu 50 55 60Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg
Ser Leu Tyr Asn65 70 75 80Thr Val Ala Thr Leu Tyr Cys Val His Gln
Arg Ile Glu Ile Lys Asp 85 90 95Thr Lys Glu Ala Leu Glu Lys Ile Glu
Glu Glu Gln Asn Lys Ser Lys 100 105 110Lys Lys Ala Gln Gln Ala Ala
Ala Asp Thr Gly Asn Ser Ser Gln Val 115 120 125Ser Gln Asn Tyr Pro
Ile Val Gln Asn Ile Gln Gly Gln Met Val His 130 135 140Gln Ala Ile
Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu145 150 155
160Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser
165 170 175Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr
Val Gly 180 185 190Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr
Ile Asn Glu Glu 195 200 205Ala Ala Glu Trp Asp Arg Val His Pro Val
His Ala Gly Pro Ile Ala 210 215 220Pro Gly Gln Met Arg Glu Pro Arg
Gly Ser Asp Ile Ala Gly Thr Thr225 230 235 240Ser Thr Leu Gln Glu
Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250 255Pro Val Gly
Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270Ile
Val Arg Met Tyr Ser Pro Val Ser Ile
Leu Asp Ile Arg Gln Gly 275 280 285Pro Lys Glu Pro Phe Arg Asp Tyr
Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300Arg Ala Glu Gln Ala Ser
Gln Asp Val Lys Asn Trp Met Thr Glu Thr305 310 315 320Leu Leu Val
Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330 335Leu
Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 340 345
350Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser
355 360 365Gln Val Thr Asn Ser Ala Thr Ile Met Met Gln Arg Gly Asn
Phe Arg 370 375 380Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly
Lys Glu Gly His385 390 395 400Ile Ala Lys Asn Cys Arg Ala Pro Arg
Lys Lys Gly Cys Trp Lys Cys 405 410 415Gly Lys Glu Gly His Gln Met
Lys Asp Cys Thr Glu Arg Gln Ala Asn 420 425 430Phe Leu Gly Lys Ile
Trp Pro Ser Asn Lys Gly Arg Pro Gly Asn Phe 435 440 445Leu Gln Asn
Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 450 455 460Phe
Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp465 470
475 480Lys Glu Met Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn
Asp 485 490 495Pro Ser Ser Gln Ala Gly Lys Trp Ser Lys Ser Ser Val
Val Gly Trp 500 505 510Pro Ala Ile Arg Glu Arg Met Arg Arg Ala Glu
Pro Ala Ala Asp Gly 515 520 525Val Gly Ala Val Ser Arg Asp Leu Glu
Lys His Gly Ala Ile Thr Ser 530 535 540Ser Asn Thr Ala Ala Asn Asn
Ala Asp Cys Ala Trp Leu Glu Ala Gln545 550 555 560Glu Glu Glu Glu
Val Gly Phe Pro Val Arg Pro Gln Val Pro Leu Arg 565 570 575Pro Met
Thr Tyr Lys Gly Ala Leu Asp Leu Ser His Phe Leu Lys Glu 580 585
590Lys Gly Gly Leu Glu Gly Leu Ile Tyr Ser Gln Lys Arg Gln Asp Ile
595 600 605Leu Asp Leu Trp Val Tyr His Thr Gln Gly Tyr Phe Pro Asp
Trp Gln 610 615 620Asn Tyr Thr Pro Gly Pro Gly Ile Arg Tyr Pro Leu
Thr Phe Gly Trp625 630 635 640Cys Phe Lys Leu Val Pro Val Glu Pro
Glu Lys Ile Glu Glu Ala Asn 645 650 655Glu Gly Glu Asn Asn Ser Leu
Leu His Pro Met Ser Gln His Gly Met 660 665 670Asp Asp Pro Glu Lys
Glu Val Leu Met Trp Lys Phe Asp Ser Arg Leu 675 680 685Ala Phe His
His Met Ala Arg Glu Leu His Pro Glu Tyr Tyr Lys Asp 690 695
700Cys70524696PRTArtificial SequenceSynthetic Construct (Mosaic
gagnef2) 24Met Gly Ala Arg Ala Ser Ile Leu Arg Gly Gly Lys Leu Asp
Lys Trp1 5 10 15Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys His Tyr
Met Leu Lys 20 25 30His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe
Ala Leu Asn Pro 35 40 45Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln
Ile Ile Lys Gln Leu 50 55 60Gln Pro Ala Leu Gln Thr Gly Thr Glu Glu
Leu Arg Ser Leu Phe Asn65 70 75 80Thr Val Ala Thr Leu Tyr Cys Val
His Ala Glu Ile Glu Val Arg Asp 85 90 95Thr Lys Glu Ala Leu Asp Lys
Ile Glu Glu Glu Gln Asn Lys Ser Gln 100 105 110Gln Lys Thr Gln Gln
Ala Lys Glu Ala Asp Gly Lys Val Ser Gln Asn 115 120 125Tyr Pro Ile
Val Gln Asn Leu Gln Gly Gln Met Val His Gln Pro Ile 130 135 140Ser
Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu Lys Ala145 150
155 160Phe Ser Pro Glu Val Ile Pro Met Phe Thr Ala Leu Ser Glu Gly
Ala 165 170 175Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly
Gly His Gln 180 185 190Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn
Glu Glu Ala Ala Glu 195 200 205Trp Asp Arg Leu His Pro Val His Ala
Gly Pro Val Ala Pro Gly Gln 210 215 220Met Arg Glu Pro Arg Gly Ser
Asp Ile Ala Gly Thr Thr Ser Asn Leu225 230 235 240Gln Glu Gln Ile
Ala Trp Met Thr Ser Asn Pro Pro Ile Pro Val Gly 245 250 255Asp Ile
Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg 260 265
270Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Lys Gln Gly Pro Lys Glu
275 280 285Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg
Ala Glu 290 295 300Gln Ala Thr Gln Asp Val Lys Asn Trp Met Thr Asp
Thr Leu Leu Val305 310 315 320Gln Asn Ala Asn Pro Asp Cys Lys Thr
Ile Leu Arg Ala Leu Gly Pro 325 330 335Gly Ala Thr Leu Glu Glu Met
Met Thr Ala Cys Gln Gly Val Gly Gly 340 345 350Pro Ser His Lys Ala
Arg Val Leu Ala Glu Ala Met Ser Gln Thr Asn 355 360 365Ser Thr Ile
Leu Met Gln Arg Ser Asn Phe Lys Gly Ser Lys Arg Ile 370 375 380Val
Lys Cys Phe Asn Cys Gly Lys Glu Gly His Ile Ala Arg Asn Cys385 390
395 400Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys Glu Gly
His 405 410 415Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu
Gly Lys Ile 420 425 430Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe
Leu Gln Ser Arg Pro 435 440 445Glu Pro Thr Ala Pro Pro Ala Glu Ser
Phe Arg Phe Glu Glu Thr Thr 450 455 460Pro Ala Pro Lys Gln Glu Pro
Lys Asp Arg Glu Pro Leu Thr Ser Leu465 470 475 480Arg Ser Leu Phe
Gly Ser Asp Pro Leu Ser Gln Ala Gly Lys Trp Ser 485 490 495Lys Ser
Ser Ile Val Gly Trp Pro Ala Val Arg Glu Arg Ile Arg Arg 500 505
510Ala Glu Pro Ala Ala Glu Gly Val Gly Ala Ala Ser Gln Asp Leu Asp
515 520 525Lys Tyr Gly Ala Leu Thr Ser Ser Asn Thr Ala Ala Thr Asn
Ala Asp 530 535 540Cys Ala Trp Leu Glu Ala Gln Glu Asp Glu Glu Val
Gly Phe Pro Val545 550 555 560Lys Pro Gln Val Pro Leu Arg Pro Met
Thr Tyr Lys Ala Ala Phe Asp 565 570 575Leu Ser Phe Phe Leu Lys Glu
Lys Gly Gly Leu Asp Gly Leu Ile Tyr 580 585 590Ser Lys Lys Arg Gln
Glu Ile Leu Asp Leu Trp Val Tyr Asn Thr Gln 595 600 605Gly Phe Phe
Pro Asp Trp Gln Asn Tyr Thr Pro Gly Pro Gly Val Arg 610 615 620Tyr
Pro Leu Thr Phe Gly Trp Cys Phe Lys Leu Val Pro Val Asp Pro625 630
635 640Arg Glu Val Glu Glu Ala Asn Lys Gly Glu Asn Asn Cys Leu Leu
His 645 650 655Pro Met Asn Leu His Gly Met Asp Asp Pro Glu Arg Glu
Val Leu Val 660 665 670Trp Arg Phe Asp Ser Arg Leu Ala Phe His His
Met Ala Arg Glu Lys 675 680 685His Pro Glu Tyr Tyr Lys Asn Cys 690
695251341PRTArtificial SequenceSynthetic Construct (Mosaic gag pol2
v3) 25Met Gly Ala Arg Ala Ser Ile Leu Arg Gly Gly Lys Leu Asp Lys
Trp1 5 10 15Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys His Tyr Met
Leu Lys 20 25 30His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala
Leu Asn Pro 35 40 45Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile
Ile Lys Gln Leu 50 55 60Gln Pro Ala Leu Gln Thr Gly Thr Glu Glu Leu
Arg Ser Leu Phe Asn65 70 75 80Thr Val Ala Thr Leu Tyr Cys Val His
Ala Glu Ile Glu Val Arg Asp 85 90 95Thr Lys Glu Ala Leu Asp Lys Ile
Glu Glu Glu Gln Asn Lys Ser Gln 100 105 110Gln Lys Thr Gln Gln Ala
Lys Glu Ala Asp Gly Lys Val Ser Gln Asn 115 120 125Tyr Pro Ile Val
Gln Asn Leu Gln Gly Gln Met Val His Gln Pro Ile 130 135 140Ser Pro
Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu Lys Ala145 150 155
160Phe Ser Pro Glu Val Ile Pro Met Phe Thr Ala Leu Ser Glu Gly Ala
165 170 175Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly
His Gln 180 185 190Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu
Glu Ala Ala Glu 195 200 205Trp Asp Arg Leu His Pro Val His Ala Gly
Pro Val Ala Pro Gly Gln 210 215 220Met Arg Glu Pro Arg Gly Ser Asp
Ile Ala Gly Thr Thr Ser Asn Leu225 230 235 240Gln Glu Gln Ile Ala
Trp Met Thr Ser Asn Pro Pro Ile Pro Val Gly 245 250 255Asp Ile Tyr
Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg 260 265 270Met
Tyr Ser Pro Thr Ser Ile Leu Asp Ile Lys Gln Gly Pro Lys Glu 275 280
285Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg Ala Glu
290 295 300Gln Ala Thr Gln Asp Val Lys Asn Trp Met Thr Asp Thr Leu
Leu Val305 310 315 320Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu
Arg Ala Leu Gly Pro 325 330 335Gly Ala Thr Leu Glu Glu Met Met Thr
Ala Cys Gln Gly Val Gly Gly 340 345 350Pro Ser His Lys Ala Arg Val
Leu Ala Glu Ala Met Ser Gln Thr Asn 355 360 365Ser Thr Ile Leu Met
Gln Arg Ser Asn Phe Lys Gly Ser Lys Arg Ile 370 375 380Val Lys Cys
Phe Asn Cys Gly Lys Glu Gly His Ile Ala Arg Asn Cys385 390 395
400Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys Glu Gly His
405 410 415Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly
Lys Ile 420 425 430Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu
Gln Ser Arg Pro 435 440 445Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe
Arg Phe Glu Glu Thr Thr 450 455 460Pro Ala Pro Lys Gln Glu Pro Lys
Asp Arg Glu Pro Leu Thr Ser Leu465 470 475 480Arg Ser Leu Phe Gly
Ser Asp Pro Leu Ser Gln Met Ala Pro Ile Ser 485 490 495Pro Ile Glu
Thr Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly Pro 500 505 510Lys
Val Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Val 515 520
525Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly
530 535 540Pro Glu Asn Pro Tyr Asn Thr Pro Ile Phe Ala Ile Lys Lys
Lys Asp545 550 555 560Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg
Glu Leu Asn Lys Arg 565 570 575Thr Gln Asp Phe Trp Glu Val Gln Leu
Gly Ile Pro His Pro Ala Gly 580 585 590Leu Lys Lys Lys Lys Ser Val
Thr Val Leu Ala Val Gly Asp Ala Tyr 595 600 605Phe Ser Val Pro Leu
Asp Glu Asp Phe Arg Lys Tyr Thr Ala Phe Thr 610 615 620Ile Pro Ser
Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn625 630 635
640Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Ser Ser
645 650 655Met Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro Asp
Ile Val 660 665 670Ile Tyr Gln Tyr Met Ala Ala Leu Tyr Val Gly Ser
Asp Leu Glu Ile 675 680 685Gly Gln His Arg Thr Lys Ile Glu Glu Leu
Arg Gln His Leu Leu Arg 690 695 700Trp Gly Phe Thr Thr Pro Asp Lys
Lys His Gln Lys Glu Pro Pro Phe705 710 715 720Leu Trp Met Gly Tyr
Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro 725 730 735Ile Val Leu
Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys 740 745 750Leu
Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys 755 760
765Val Lys Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu Thr Glu
770 775 780Val Val Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu
Asn Arg785 790 795 800Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr
Tyr Asp Pro Ser Lys 805 810 815Asp Leu Ile Ala Glu Ile Gln Lys Gln
Gly Gln Gly Gln Trp Thr Tyr 820 825 830Gln Ile Tyr Gln Glu Pro Phe
Lys Asn Leu Lys Thr Gly Lys Tyr Ala 835 840 845Arg Met Arg Gly Ala
His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala 850 855 860Val Gln Lys
Ile Ala Thr Glu Ser Ile Val Ile Trp Gly Lys Thr Pro865 870 875
880Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Ala Trp Trp Thr
885 890 895Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe Val
Asn Thr 900 905 910Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys
Glu Pro Ile Val 915 920 925Gly Ala Glu Thr Phe Tyr Val Ala Gly Ala
Ala Asn Arg Glu Thr Lys 930 935 940Leu Gly Lys Ala Gly Tyr Val Thr
Asp Arg Gly Arg Gln Lys Val Val945 950 955 960Ser Leu Thr Asp Thr
Thr Asn Gln Lys Thr Ala Leu Gln Ala Ile His 965 970 975Leu Ala Leu
Gln Asp Ser Gly Leu Glu Val Asn Ile Val Thr Ala Ser 980 985 990Gln
Tyr Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Lys Ser Glu Ser 995
1000 1005Glu Leu Val Ser Gln Ile Ile Glu Gln Leu Ile Lys Lys Glu
Lys 1010 1015 1020Val Tyr Leu Ala Trp Val Pro Ala His Lys Gly Ile
Gly Gly Asn 1025 1030 1035Glu Gln Val Asp Lys Leu Val Ser Arg Gly
Ile Arg Lys Val Leu 1040 1045 1050Phe Leu Asp Gly Ile Asp Lys Ala
Gln Glu Glu His Glu Lys Tyr 1055 1060 1065His Ser Asn Trp Arg Ala
Met Ala Ser Glu Phe Asn Leu Pro Pro 1070 1075 1080Ile Val Ala Lys
Glu Ile Val Ala Ser Cys Asp Lys Cys Gln Leu 1085 1090 1095Lys Gly
Glu Ala Ile His Gly Gln Val Asp Cys Ser Pro Gly Ile 1100 1105
1110Trp Gln Leu Ala Cys Thr His Leu Glu Gly Lys Val Ile Leu Val
1115 1120 1125Ala Val His Val Ala Ser Gly Tyr Ile Glu Ala Glu Val
Ile Pro 1130 1135 1140Ala Glu Thr Gly Gln Glu Thr Ala Tyr Phe Leu
Leu Lys Leu Ala 1145 1150 1155Gly Arg Trp Pro Val Lys Thr Ile His
Thr Ala Asn Gly Ser Asn 1160 1165 1170Phe Thr Ser Ala Thr Val Lys
Ala Ala Cys Trp Trp Ala Gly Ile 1175 1180 1185Lys Gln Glu Phe Gly
Ile Pro Tyr Asn Pro Gln Ser Gln Gly Val 1190 1195 1200Val Ala Ser
Ile Asn Lys Glu Leu Lys Lys Ile Ile Gly Gln Val 1205 1210 1215Arg
Asp Gln Ala Glu His Leu Lys Thr Ala Val Gln Met Ala Val 1220 1225
1230Phe Ile His Asn Phe Lys Arg Lys Gly Gly Ile Gly Glu Tyr Ser
1235 1240 1245Ala Gly Glu Arg Ile Val Asp Ile Ile Ala Ser Asp Ile
Gln Thr 1250 1255 1260Lys Glu Leu Gln Lys Gln Ile Thr Lys Ile Gln
Asn Phe Arg Val 1265 1270 1275Tyr Tyr Arg Asp Ser Arg Asp Pro Leu
Trp Lys Gly Pro Ala Lys 1280 1285 1290Leu Leu Trp Lys Gly Glu Gly
Ala Val Val Ile Gln Asp Asn Ser 1295 1300 1305Asp Ile Lys Val Val
Pro Arg Arg Lys Ala Lys Ile Ile Arg Asp 1310 1315 1320Tyr Gly Lys
Gln Met
Ala Gly Asp Asp Cys Val Ala Ser Arg Gln 1325 1330 1335Asp Glu Asp
1340261359PRTArtificial SequenceSynthetic Construct (Mos3 gag-pol
v3) 26Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Lys Leu Asp Ala
Trp1 5 10 15Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys
Leu Lys 20 25 30His Ile Val Trp Ala Ser Arg Glu Leu Asp Arg Phe Ala
Leu Asn Pro 35 40 45Gly Leu Leu Glu Thr Ala Glu Gly Cys Gln Gln Ile
Ile Glu Gln Leu 50 55 60Gln Pro Ala Leu Gln Thr Gly Ser Glu Glu Leu
Lys Ser Leu Tyr Asn65 70 75 80Thr Val Ala Val Leu Tyr Cys Val His
Gln Arg Ile Asp Val Lys Asp 85 90 95Thr Lys Glu Ala Leu Asp Lys Ile
Glu Glu Ile Gln Asn Lys Ser Lys 100 105 110Gln Lys Thr Gln Gln Ala
Ala Ala Asp Thr Gly Ser Ser Ser Lys Val 115 120 125Ser Gln Asn Tyr
Pro Ile Val Gln Asn Ala Gln Gly Gln Met Val His 130 135 140Gln Ala
Leu Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu145 150 155
160Glu Lys Gly Phe Asn Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ala
165 170 175Glu Gly Ala Thr Pro Gln Asp Leu Asn Met Met Leu Asn Ile
Val Gly 180 185 190Gly His Gln Ala Ala Met Gln Ile Leu Lys Asp Thr
Ile Asn Glu Glu 195 200 205Ala Ala Asp Trp Asp Arg Leu His Pro Val
His Ala Gly Pro Ile Pro 210 215 220Pro Gly Gln Met Arg Glu Pro Arg
Gly Ser Asp Ile Ala Gly Thr Thr225 230 235 240Ser Thr Pro Gln Glu
Gln Ile Gly Trp Met Thr Ser Asn Pro Pro Val 245 250 255Pro Val Gly
Glu Ile Tyr Lys Arg Trp Ile Ile Met Gly Leu Asn Lys 260 265 270Ile
Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Lys Gln Gly 275 280
285Pro Lys Glu Ser Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Val Leu
290 295 300Arg Ala Glu Gln Ala Thr Gln Glu Val Lys Asn Trp Met Thr
Glu Thr305 310 315 320Leu Leu Ile Gln Asn Ala Asn Pro Asp Cys Lys
Ser Ile Leu Arg Ala 325 330 335Leu Gly Pro Gly Ala Ser Leu Glu Glu
Met Met Thr Ala Cys Gln Gly 340 345 350Val Gly Gly Pro Ser His Lys
Ala Arg Ile Leu Ala Glu Ala Met Ser 355 360 365Gln Ala Asn Asn Thr
Asn Ile Met Met Gln Arg Gly Asn Phe Lys Gly 370 375 380Gln Lys Arg
Ile Lys Cys Phe Asn Cys Gly Lys Glu Gly His Leu Ala385 390 395
400Arg Asn Cys Arg Ala Pro Arg Lys Arg Gly Cys Trp Lys Cys Gly Arg
405 410 415Glu Gly His Gln Met Lys Asp Cys Asn Glu Arg Gln Ala Asn
Phe Leu 420 425 430Gly Lys Ile Trp Pro Ser Ser Lys Gly Arg Pro Gly
Asn Phe Pro Gln 435 440 445Ser Arg Pro Glu Pro Thr Ala Pro Leu Glu
Pro Thr Ala Pro Pro Ala 450 455 460Glu Pro Thr Ala Pro Pro Ala Glu
Ser Phe Gly Phe Gly Glu Glu Ile465 470 475 480Thr Pro Ser Pro Lys
Gln Glu Gln Lys Asp Arg Glu Pro Leu Thr Ser 485 490 495Leu Lys Ser
Leu Phe Gly Ser Asp Pro Leu Leu Gln Met Ala Pro Ile 500 505 510Ser
Pro Ile Asp Thr Val Pro Val Thr Leu Lys Pro Gly Met Asp Gly 515 520
525Pro Lys Ile Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu
530 535 540Thr Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser
Arg Ile545 550 555 560Gly Pro Glu Asn Pro Tyr Asn Thr Pro Val Phe
Ala Ile Lys Lys Lys 565 570 575Asn Ser Thr Arg Trp Arg Lys Leu Val
Asp Phe Arg Glu Leu Asn Lys 580 585 590Lys Thr Gln Asp Phe Trp Glu
Val Gln Leu Gly Ile Pro His Pro Ala 595 600 605Gly Leu Lys Lys Lys
Arg Ser Val Thr Val Leu Ala Val Gly Asp Ala 610 615 620Tyr Phe Ser
Val Pro Leu Asp Lys Asp Phe Arg Lys Tyr Thr Ala Phe625 630 635
640Thr Ile Pro Ser Val Asn Asn Glu Thr Pro Gly Val Arg Tyr Gln Tyr
645 650 655Asn Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe
Gln Cys 660 665 670Ser Met Thr Lys Ile Leu Glu Pro Phe Arg Ala Gln
Asn Pro Glu Ile 675 680 685Val Ile Tyr Gln Tyr Val Ala Ala Leu Tyr
Val Gly Ser Asp Leu Glu 690 695 700Ile Glu Gln His Arg Thr Lys Ile
Glu Glu Leu Arg Ala His Leu Leu705 710 715 720Ser Trp Gly Phe Thr
Thr Pro Asp Lys Lys His Gln Arg Glu Pro Pro 725 730 735Phe Leu Trp
Met Gly Tyr Glu Leu His Pro Asp Arg Trp Thr Val Gln 740 745 750Pro
Ile Glu Leu Pro Glu Lys Glu Ser Trp Thr Val Asn Asp Ile Gln 755 760
765Lys Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Pro Gly Ile
770 775 780Lys Val Lys Gln Leu Cys Arg Leu Leu Arg Gly Ala Lys Ala
Leu Thr785 790 795 800Glu Val Ile Pro Leu Thr Lys Glu Ala Glu Leu
Glu Leu Ala Glu Asn 805 810 815Arg Glu Ile Leu Arg Glu Pro Val His
Gly Val Tyr Tyr Asp Pro Ser 820 825 830Lys Asp Leu Val Ala Glu Ile
Gln Lys Gln Gly Gln Asp Gln Trp Thr 835 840 845Tyr Gln Ile Tyr Gln
Glu Pro Tyr Lys Asn Leu Lys Thr Gly Lys Tyr 850 855 860Ala Arg Lys
Arg Ser Ala His Thr Asn Asp Val Arg Gln Leu Thr Glu865 870 875
880Ala Val Gln Lys Ile Ala Leu Glu Ser Ile Val Ile Trp Gly Lys Ile
885 890 895Pro Lys Phe Arg Leu Pro Ile Gln Arg Glu Thr Trp Glu Thr
Trp Trp 900 905 910Thr Glu Tyr Trp Gln Ala Thr Trp Ile Pro Asp Trp
Glu Phe Val Asn 915 920 925Thr Pro Pro Leu Val Lys Leu Trp Tyr Gln
Leu Glu Lys Glu Pro Ile 930 935 940Ala Gly Ala Glu Thr Phe Tyr Val
Ala Gly Ala Ser Asn Arg Glu Thr945 950 955 960Lys Ile Gly Lys Ala
Gly Tyr Val Thr Asp Lys Gly Arg Gln Lys Val 965 970 975Val Ser Leu
Thr Glu Thr Thr Asn Gln Lys Ala Ala Leu Gln Ala Ile 980 985 990Gln
Leu Ala Leu Gln Asp Ser Gly Pro Glu Val Asn Ile Val Thr Ala 995
1000 1005Ser Gln Tyr Val Leu Gly Ile Ile Gln Ala Gln Pro Asp Arg
Ser 1010 1015 1020Glu Ser Glu Leu Val Asn Gln Ile Ile Glu Glu Leu
Ile Lys Lys 1025 1030 1035Glu Lys Val Tyr Leu Ser Trp Val Pro Ala
His Lys Gly Ile Gly 1040 1045 1050Gly Asn Glu Gln Val Asp Lys Leu
Val Ser Ala Gly Ile Arg Lys 1055 1060 1065Ile Leu Phe Leu Asp Gly
Ile Asp Lys Ala Gln Glu Glu His Glu 1070 1075 1080Arg Tyr His Ser
Asn Trp Arg Thr Met Ala Ser Asp Phe Asn Leu 1085 1090 1095Pro Pro
Ile Val Ala Lys Glu Ile Val Ala Asn Cys Asp Lys Cys 1100 1105
1110Gln Leu Lys Gly Glu Ala Met His Gly Gln Val Asp Cys Ser Pro
1115 1120 1125Gly Met Trp Gln Leu Ala Cys Thr His Leu Glu Gly Lys
Ile Ile 1130 1135 1140Ile Val Ala Val His Val Ala Ser Gly Tyr Met
Glu Ala Glu Val 1145 1150 1155Ile Pro Ala Glu Thr Gly Gln Glu Thr
Ala Tyr Tyr Ile Leu Lys 1160 1165 1170Leu Ala Gly Arg Trp Pro Val
Lys Val Val His Thr Ala Asn Gly 1175 1180 1185Ser Asn Phe Thr Ser
Thr Thr Val Lys Ala Ala Cys Trp Trp Ala 1190 1195 1200Asn Val Thr
Gln Glu Phe Gly Ile Pro Tyr Asn Pro Gln Ser Gln 1205 1210 1215Gly
Val Ile Ala Ser Met Asn Lys Glu Leu Lys Lys Ile Ile Gly 1220 1225
1230Gln Val Arg Glu Gln Ala Glu His Leu Lys Thr Ala Val Gln Met
1235 1240 1245Ala Val Leu Ile His Asn Phe Lys Arg Arg Gly Gly Ile
Gly Gly 1250 1255 1260Tyr Ser Ala Gly Glu Arg Ile Val Asp Ile Ile
Ala Thr Asp Ile 1265 1270 1275Gln Thr Arg Glu Leu Gln Lys Gln Ile
Ile Lys Ile Gln Asn Phe 1280 1285 1290Arg Val Tyr Phe Arg Asp Ser
Arg Asp Pro Val Trp Lys Gly Pro 1295 1300 1305Ala Lys Leu Leu Trp
Lys Gly Glu Gly Ala Val Val Ile Gln Asp 1310 1315 1320Asn Ser Glu
Ile Lys Val Val Pro Arg Arg Lys Val Lys Ile Ile 1325 1330 1335Arg
Asp Tyr Gly Lys Gln Met Ala Gly Asp Asp Cys Val Ala Gly 1340 1345
1350Arg Gln Asp Glu Asp Gln 1355271497PRTArtificial
SequenceSynthetic Construct (Mosaic gagpol1 v4) 27Met Gly Ala Arg
Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp1 5 10 15Glu Lys Ile
Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys 20 25 30His Ile
Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45Gly
Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55
60Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn65
70 75 80Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys
Asp 85 90 95Thr Lys Glu Ala Leu Glu Lys Ile Glu Glu Glu Gln Asn Lys
Ser Lys 100 105 110Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn
Ser Ser Gln Val 115 120 125Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile
Gln Gly Gln Met Val His 130 135 140Gln Ala Ile Ser Pro Arg Thr Leu
Asn Ala Trp Val Lys Val Val Glu145 150 155 160Glu Lys Ala Phe Ser
Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175Glu Gly Ala
Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190Gly
His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200
205Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala
210 215 220Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly
Thr Thr225 230 235 240Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr
Asn Asn Pro Pro Ile 245 250 255Pro Val Gly Glu Ile Tyr Lys Arg Trp
Ile Ile Leu Gly Leu Asn Lys 260 265 270Ile Val Arg Met Tyr Ser Pro
Val Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285Pro Lys Glu Pro Phe
Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300Arg Ala Glu
Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr305 310 315
320Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala
325 330 335Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys
Gln Gly 340 345 350Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala
Glu Ala Met Ser 355 360 365Gln Val Thr Asn Ser Ala Thr Ile Met Met
Gln Arg Gly Asn Phe Arg 370 375 380Asn Gln Arg Lys Thr Val Lys Cys
Phe Asn Cys Gly Lys Glu Gly His385 390 395 400Ile Ala Lys Asn Cys
Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 405 410 415Gly Lys Glu
Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 420 425 430Phe
Leu Gly Lys Ile Trp Pro Ser Asn Lys Gly Arg Pro Gly Asn Phe 435 440
445Leu Gln Asn Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg
450 455 460Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro
Ile Asp465 470 475 480Lys Glu Met Tyr Pro Leu Ala Ser Leu Lys Ser
Leu Phe Gly Asn Asp 485 490 495Pro Ser Ser Gln Arg Glu Asn Leu Ala
Phe Gln Gln Gly Glu Ala Arg 500 505 510Glu Phe Pro Ser Glu Gln Thr
Arg Ala Asn Ser Pro Thr Ser Arg Glu 515 520 525Leu Gln Val Arg Gly
Asp Asn Pro His Ser Glu Ala Gly Ala Glu Arg 530 535 540Gln Gly Thr
Leu Asn Phe Pro Gln Ile Thr Leu Trp Gln Arg Pro Leu545 550 555
560Val Ser Ile Lys Val Gly Gly Gln Ile Arg Glu Ala Leu Leu Ala Thr
565 570 575Gly Ala Asp Asp Thr Val Leu Glu Asp Ile Asn Leu Pro Gly
Lys Trp 580 585 590Lys Pro Lys Met Ile Gly Gly Ile Gly Gly Phe Ile
Lys Val Gly Gln 595 600 605Tyr Asp Gln Ile Leu Ile Glu Ile Cys Gly
Lys Lys Ala Ile Gly Thr 610 615 620Val Leu Val Gly Pro Thr Pro Val
Asn Ile Ile Gly Arg Asn Met Leu625 630 635 640Thr Gln Leu Gly Cys
Thr Leu Asn Phe Pro Ile Ser Pro Ile Glu Thr 645 650 655Val Pro Val
Lys Leu Lys Pro Gly Met Asp Gly Pro Arg Val Lys Gln 660 665 670Trp
Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Thr Ala Ile Cys Glu 675 680
685Glu Met Glu Lys Glu Gly Lys Ile Thr Lys Ile Gly Pro Glu Asn Pro
690 695 700Tyr Asn Thr Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr
Lys Trp705 710 715 720Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys
Arg Thr Gln Asp Phe 725 730 735Trp Glu Val Gln Leu Gly Ile Pro His
Pro Ala Gly Leu Lys Lys Lys 740 745 750Lys Ser Val Thr Val Leu Asp
Val Gly Asp Ala Tyr Phe Ser Val Pro 755 760 765Leu Asp Glu Gly Phe
Arg Lys Tyr Thr Ala Phe Thr Ile Pro Ser Thr 770 775 780Asn Asn Glu
Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu Pro Gln785 790 795
800Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Cys Ser Met Thr Arg Ile
805 810 815Leu Glu Pro Phe Arg Ala Lys Asn Pro Glu Ile Val Ile Tyr
Gln Tyr 820 825 830Met Asp His Leu Tyr Val Gly Ser Asp Leu Glu Ile
Gly Gln His Arg 835 840 845Ala Lys Ile Glu Glu Leu Arg Glu His Leu
Leu Lys Trp Gly Phe Thr 850 855 860Thr Pro Asp Lys Lys His Gln Lys
Glu Pro Pro Phe Leu Trp Met Gly865 870 875 880Tyr Glu Leu His Pro
Asp Lys Trp Thr Val Gln Pro Ile Gln Leu Pro 885 890 895Glu Lys Asp
Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val Gly Lys 900 905 910Leu
Asn Trp Ala Ser Gln Ile Tyr Pro Gly Ile Lys Val Arg Gln Leu 915 920
925Cys Lys Leu Leu Arg Gly Ala Lys Ala Leu Thr Asp Ile Val Pro Leu
930 935 940Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile
Leu Lys945 950 955 960Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser
Lys Asp Leu Ile Ala 965 970 975Glu Ile Gln Lys Gln Gly His Asp Gln
Trp Thr Tyr Gln Ile Tyr Gln 980 985 990Glu Pro Phe Lys Asn Leu Lys
Thr Gly Lys Tyr Ala Lys Met Arg Thr 995 1000 1005Ala His Thr Asn
Asp Val Lys Gln Leu Thr Glu Ala Val Gln Lys 1010 1015 1020Ile Ala
Met Glu Ser Ile Val Ile Trp Gly Lys Thr Pro Lys Phe 1025 1030
1035Arg Leu Pro Ile Gln Lys Glu Thr Trp Glu Thr Trp Trp Thr Asp
1040 1045 1050Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe Val
Asn Thr 1055 1060 1065Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu
Glu Lys Asp Pro Ile 1070 1075 1080Ala Gly Val Glu Thr Phe Tyr Val
Asp Gly Ala Ala Asn Arg Glu 1085 1090 1095Thr Lys Leu Gly Lys Ala
Gly Tyr Val Thr Asp Arg Gly Arg Gln 1100 1105 1110Lys Ile Val Ser
Leu Thr Glu Thr Thr Asn Gln Lys Thr Glu Leu 1115 1120 1125Gln Ala
Ile Tyr Leu Ala Leu Gln Asp Ser Gly Ser Glu Val Asn 1130 1135
1140Ile Val Thr Asp Ser Gln Tyr Ala Leu Gly Ile Ile Gln Ala Gln
1145 1150 1155Pro Asp Lys Ser Glu Ser Glu Leu Val Asn Gln Ile Ile
Glu Gln 1160 1165 1170Leu Ile Lys Lys Glu Arg Val Tyr Leu Ser Trp
Val Pro Ala His 1175 1180 1185Lys Gly Ile Gly Gly Asn Glu Gln Val
Asp Lys Leu Val Ser Ser 1190 1195 1200Gly Ile Arg Lys Val Leu Phe
Leu Asp Gly Ile Asp Lys Ala Gln 1205 1210 1215Glu Glu His Glu Lys
Tyr His Ser Asn Trp Arg Ala Met Ala Ser 1220 1225 1230Asp Phe Asn
Leu Pro Pro Val Val Ala Lys Glu Ile Val Ala Ser 1235 1240 1245Cys
Asp Gln Cys Gln Leu Lys Gly Glu Ala Met His Gly Gln Val 1250 1255
1260Asp Cys Ser Pro Gly Ile Trp Gln Leu Ala Cys Thr His Leu Glu
1265 1270 1275Gly Lys Ile Ile Leu Val Ala Val His Val Ala Ser Gly
Tyr Ile 1280 1285 1290Glu Ala Glu Val Ile Pro Ala Glu Thr Gly Gln
Glu Thr Ala Tyr 1295 1300 1305Phe Ile Leu Lys Leu Ala Gly Arg Trp
Pro Val Lys Val Ile His 1310 1315 1320Thr Asp Asn Gly Ser Asn Phe
Thr Ser Ala Ala Val Lys Ala Ala 1325 1330 1335Cys Trp Trp Ala Gly
Ile Gln Gln Glu Phe Gly Ile Pro Tyr Asn 1340 1345 1350Pro Gln Ser
Gln Gly Val Val Glu Ser Met Asn Lys Glu Leu Lys 1355 1360 1365Lys
Ile Ile Gly Gln Val Arg Asp Gln Ala Glu His Leu Lys Thr 1370 1375
1380Ala Val Gln Met Ala Val Phe Ile His Asn Phe Lys Arg Lys Gly
1385 1390 1395Gly Ile Gly Gly Tyr Ser Ala Gly Glu Arg Ile Ile Asp
Ile Ile 1400 1405 1410Ala Thr Asp Ile Gln Thr Lys Glu Leu Gln Lys
Gln Ile Ile Lys 1415 1420 1425Ile Gln Asn Phe Arg Val Tyr Tyr Arg
Asp Ser Arg Asp Pro Ile 1430 1435 1440Trp Lys Gly Pro Ala Lys Leu
Leu Trp Lys Gly Glu Gly Ala Val 1445 1450 1455Val Ile Gln Asp Asn
Ser Asp Ile Lys Val Val Pro Arg Arg Lys 1460 1465 1470Val Lys Ile
Ile Lys Asp Tyr Gly Lys Gln Met Ala Gly Ala Asp 1475 1480 1485Cys
Val Ala Gly Arg Gln Asp Glu Asp 1490 1495281492PRTArtificial
SequenceSynthetic Construct (Mosaic gagpol2 v4) 28Met Gly Ala Arg
Ala Ser Ile Leu Arg Gly Gly Lys Leu Asp Lys Trp1 5 10 15Glu Lys Ile
Arg Leu Arg Pro Gly Gly Lys Lys His Tyr Met Leu Lys 20 25 30His Leu
Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn Pro 35 40 45Gly
Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Lys Gln Leu 50 55
60Gln Pro Ala Leu Gln Thr Gly Thr Glu Glu Leu Arg Ser Leu Phe Asn65
70 75 80Thr Val Ala Thr Leu Tyr Cys Val His Ala Glu Ile Glu Val Arg
Asp 85 90 95Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys
Ser Gln 100 105 110Gln Lys Thr Gln Gln Ala Lys Glu Ala Asp Gly Lys
Val Ser Gln Asn 115 120 125Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln
Met Val His Gln Pro Ile 130 135 140Ser Pro Arg Thr Leu Asn Ala Trp
Val Lys Val Ile Glu Glu Lys Ala145 150 155 160Phe Ser Pro Glu Val
Ile Pro Met Phe Thr Ala Leu Ser Glu Gly Ala 165 170 175Thr Pro Gln
Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln 180 185 190Ala
Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu Glu Ala Ala Glu 195 200
205Trp Asp Arg Leu His Pro Val His Ala Gly Pro Val Ala Pro Gly Gln
210 215 220Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser
Asn Leu225 230 235 240Gln Glu Gln Ile Ala Trp Met Thr Ser Asn Pro
Pro Ile Pro Val Gly 245 250 255Asp Ile Tyr Lys Arg Trp Ile Ile Leu
Gly Leu Asn Lys Ile Val Arg 260 265 270Met Tyr Ser Pro Thr Ser Ile
Leu Asp Ile Lys Gln Gly Pro Lys Glu 275 280 285Pro Phe Arg Asp Tyr
Val Asp Arg Phe Phe Lys Thr Leu Arg Ala Glu 290 295 300Gln Ala Thr
Gln Asp Val Lys Asn Trp Met Thr Asp Thr Leu Leu Val305 310 315
320Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg Ala Leu Gly Pro
325 330 335Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val
Gly Gly 340 345 350Pro Ser His Lys Ala Arg Val Leu Ala Glu Ala Met
Ser Gln Thr Asn 355 360 365Ser Thr Ile Leu Met Gln Arg Ser Asn Phe
Lys Gly Ser Lys Arg Ile 370 375 380Val Lys Cys Phe Asn Cys Gly Lys
Glu Gly His Ile Ala Arg Asn Cys385 390 395 400Arg Ala Pro Arg Lys
Lys Gly Cys Trp Lys Cys Gly Lys Glu Gly His 405 410 415Gln Met Lys
Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly Lys Ile 420 425 430Trp
Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu Gln Ser Arg Pro 435 440
445Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Arg Phe Glu Glu Thr Thr
450 455 460Pro Ala Pro Lys Gln Glu Pro Lys Asp Arg Glu Pro Leu Thr
Ser Leu465 470 475 480Arg Ser Leu Phe Gly Ser Asp Pro Leu Ser Gln
Arg Glu Asn Leu Ala 485 490 495Phe Pro Gln Gly Lys Ala Arg Glu Phe
Ser Ser Glu Gln Thr Arg Ala 500 505 510Asn Ser Pro Thr Arg Arg Glu
Leu Gln Val Trp Gly Arg Asp Asn Asn 515 520 525Ser Leu Ser Glu Ala
Gly Ala Asp Arg Gln Gly Thr Val Ser Phe Ser 530 535 540Phe Pro Gln
Ile Thr Leu Trp Gln Arg Pro Leu Val Thr Ile Lys Ile545 550 555
560Gly Gly Gln Leu Lys Glu Ala Leu Leu Ala Thr Gly Ala Asp Asp Thr
565 570 575Val Leu Glu Glu Met Asn Leu Pro Gly Arg Trp Lys Pro Lys
Met Ile 580 585 590Gly Gly Ile Gly Gly Phe Ile Lys Val Gly Gln Tyr
Asp Gln Ile Pro 595 600 605Ile Glu Ile Cys Gly His Lys Ala Ile Gly
Thr Val Leu Val Gly Pro 610 615 620Thr Pro Val Asn Ile Ile Gly Arg
Asn Leu Leu Thr Gln Ile Gly Cys625 630 635 640Thr Leu Asn Phe Pro
Ile Ser Pro Ile Glu Thr Val Pro Val Lys Leu 645 650 655Lys Pro Gly
Met Asp Gly Pro Lys Val Lys Gln Trp Pro Leu Thr Glu 660 665 670Glu
Lys Ile Lys Ala Leu Val Glu Ile Cys Thr Glu Met Glu Lys Glu 675 680
685Gly Lys Ile Ser Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr Pro Ile
690 695 700Phe Ala Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu
Val Asp705 710 715 720Phe Arg Glu Leu Asn Lys Arg Thr Gln Asp Phe
Trp Glu Val Gln Leu 725 730 735Gly Ile Pro His Pro Ala Gly Leu Lys
Lys Lys Lys Ser Val Thr Val 740 745 750Leu Asp Val Gly Asp Ala Tyr
Phe Ser Val Pro Leu Asp Glu Asp Phe 755 760 765Arg Lys Tyr Thr Ala
Phe Thr Ile Pro Ser Ile Asn Asn Glu Thr Pro 770 775 780Gly Ile Arg
Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys Gly Ser785 790 795
800Pro Ala Ile Phe Gln Ser Ser Met Thr Lys Ile Leu Glu Pro Phe Arg
805 810 815Lys Gln Asn Pro Asp Ile Val Ile Tyr Gln Tyr Met Asp His
Leu Tyr 820 825 830Val Gly Ser Asp Leu Glu Ile Gly Gln His Arg Thr
Lys Ile Glu Glu 835 840 845Leu Arg Gln His Leu Leu Arg Trp Gly Phe
Thr Thr Pro Asp Lys Lys 850 855 860His Gln Lys Glu Pro Pro Phe Leu
Trp Met Gly Tyr Glu Leu His Pro865 870 875 880Asp Lys Trp Thr Val
Gln Pro Ile Val Leu Pro Glu Lys Asp Ser Trp 885 890 895Thr Val Asn
Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp Ala Ser 900 905 910Gln
Ile Tyr Ala Gly Ile Lys Val Lys Gln Leu Cys Lys Leu Leu Arg 915 920
925Gly Thr Lys Ala Leu Thr Glu Val Val Pro Leu Thr Glu Glu Ala Glu
930 935 940Leu Glu Leu Ala Glu Asn Arg Glu Ile Leu Lys Glu Pro Val
His Gly945 950 955 960Val Tyr Tyr Asp Pro Ser Lys Asp Leu Ile Ala
Glu Ile Gln Lys Gln 965 970 975Gly Gln Gly Gln Trp Thr Tyr Gln Ile
Tyr Gln Glu Pro Phe Lys Asn 980 985 990Leu Lys Thr Gly Lys Tyr Ala
Arg Met Arg Gly Ala His Thr Asn Asp 995 1000 1005Val Lys Gln Leu
Thr Glu Ala Val Gln Lys Ile Ala Thr Glu Ser 1010 1015 1020Ile Val
Ile Trp Gly Lys Thr Pro Lys Phe Lys Leu Pro Ile Gln 1025 1030
1035Lys Glu Thr Trp Glu Ala Trp Trp Thr Glu Tyr Trp Gln Ala Thr
1040 1045 1050Trp Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro Leu
Val Lys 1055 1060 1065Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Val
Gly Ala Glu Thr 1070 1075 1080Phe Tyr Val Asp Gly Ala Ala Asn Arg
Glu Thr Lys Leu Gly Lys 1085 1090 1095Ala Gly Tyr Val Thr Asp Arg
Gly Arg Gln Lys Val Val Ser Leu 1100 1105 1110Thr Asp Thr Thr Asn
Gln Lys Thr Glu Leu Gln Ala Ile His Leu 1115 1120 1125Ala Leu Gln
Asp Ser Gly Leu Glu Val Asn Ile Val Thr Asp Ser 1130 1135 1140Gln
Tyr Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Lys Ser Glu 1145 1150
1155Ser Glu Leu Val Ser Gln Ile Ile Glu Gln Leu Ile Lys Lys Glu
1160 1165 1170Lys Val Tyr Leu Ala Trp Val Pro Ala His Lys Gly Ile
Gly Gly 1175 1180 1185Asn Glu Gln Val Asp Lys Leu Val Ser Arg Gly
Ile Arg Lys Val 1190 1195 1200Leu Phe Leu Asp Gly Ile Asp Lys Ala
Gln Glu Glu His Glu Lys 1205 1210 1215Tyr His Ser Asn Trp Arg Ala
Met Ala Ser Glu Phe Asn Leu Pro 1220 1225 1230Pro Ile Val Ala Lys
Glu Ile Val Ala Ser Cys Asp Lys Cys Gln 1235 1240 1245Leu Lys Gly
Glu Ala Ile His Gly Gln Val Asp Cys Ser Pro Gly 1250 1255 1260Ile
Trp Gln Leu Ala Cys Thr His Leu Glu Gly Lys Val Ile Leu 1265 1270
1275Val Ala Val His Val Ala Ser Gly Tyr Ile Glu Ala Glu Val Ile
1280 1285 1290Pro Ala Glu Thr Gly Gln Glu Thr Ala Tyr Phe Leu Leu
Lys Leu 1295 1300 1305Ala Gly Arg Trp Pro Val Lys Thr Ile His Thr
Asp Asn Gly Ser 1310 1315 1320Asn Phe Thr Ser Ala Thr Val Lys Ala
Ala Cys Trp Trp Ala Gly 1325 1330 1335Ile Lys Gln Glu Phe Gly Ile
Pro Tyr Asn Pro Gln Ser Gln Gly 1340 1345 1350Val Val Glu Ser Ile
Asn Lys Glu Leu Lys Lys Ile Ile Gly Gln 1355 1360 1365Val Arg Asp
Gln Ala Glu His Leu Lys Thr Ala Val Gln Met Ala 1370 1375 1380Val
Phe Ile His Asn Phe Lys Arg Lys Gly Gly Ile Gly Glu Tyr 1385 1390
1395Ser Ala Gly Glu Arg Ile Val Asp Ile Ile Ala Ser Asp Ile Gln
1400 1405 1410Thr Lys Glu Leu Gln Lys Gln Ile Thr Lys Ile Gln Asn
Phe Arg 1415 1420 1425Val Tyr Tyr Arg Asp Ser Arg Asp Pro Leu Trp
Lys Gly Pro Ala 1430 1435 1440Lys Leu Leu Trp Lys Gly Glu Gly Ala
Val Val Ile Gln Asp Asn 1445 1450 1455Ser Asp Ile Lys Val Val Pro
Arg Arg Lys Ala Lys Ile Ile Arg 1460 1465 1470Asp Tyr Gly Lys Gln
Met Ala Gly Asp Asp Cys Val Ala Ser Arg 1475 1480 1485Gln Asp Glu
Asp 1490291350PRTArtificial SequenceSynthetic Construct (Mosaic
gagpol1 v5) 29Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu
Asp Arg Trp1 5 10 15Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys
Tyr Arg Leu Lys 20 25 30His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg
Phe Ala Val Asn Pro 35 40 45Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg
Gln Ile Leu Gly Gln Leu 50 55 60Gln Pro Ser Leu Gln Thr Gly Ser Glu
Glu Leu Arg Ser Leu Tyr Asn65 70 75 80Thr Val Ala Thr Leu Tyr Cys
Val His Gln Arg Ile Glu Ile Lys Asp 85 90 95Thr Lys Glu Ala Leu Glu
Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110Lys Lys Ala Gln
Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val 115 120 125Ser Gln
Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 130 135
140Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val
Glu145 150 155 160Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe
Ser Ala Leu Ser 165 170 175Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr
Met Leu Asn Thr Val Gly 180 185 190Gly His Gln Ala Ala Met Gln Met
Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205Ala Ala Glu Trp Asp Arg
Val His Pro Val His Ala Gly Pro Ile Ala 210 215 220Pro Gly Gln Met
Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr225 230 235 240Ser
Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250
255Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys
260 265 270Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg
Gln Gly 275 280 285Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe
Tyr Lys Thr Leu 290 295 300Arg Ala Glu Gln Ala Ser Gln Asp Val Lys
Asn Trp Met Thr Glu Thr305 310 315 320Leu Leu Val Gln Asn Ala Asn
Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330 335Leu Gly Pro Ala Ala
Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 340 345 350Val Gly Gly
Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 355 360 365Gln
Val Thr Asn Ser Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 370 375
380Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu Gly
His385 390 395 400Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly
Cys Trp Lys Cys 405 410 415Gly Lys Glu Gly His Gln Met Lys Asp Cys
Thr Glu Arg Gln Ala Asn 420 425 430Phe Leu Gly Lys Ile Trp Pro Ser
Asn Lys Gly Arg Pro Gly Asn Phe 435 440 445Leu Gln Asn Arg Pro Glu
Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 450 455 460Phe Gly Glu Glu
Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp465 470 475 480Lys
Glu Met Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp 485 490
495Pro Ser Ser Gln Met Ala Pro Ile Ser Pro Ile Glu Thr Val Pro Val
500 505 510Lys Leu Lys Pro Gly Met Asp Gly Pro Arg Val Lys Gln Trp
Pro Leu 515
520 525Thr Glu Glu Lys Ile Lys Ala Leu Thr Ala Ile Cys Glu Glu Met
Glu 530 535 540Lys Glu Gly Lys Ile Thr Lys Ile Gly Pro Glu Asn Pro
Tyr Asn Thr545 550 555 560Pro Val Phe Ala Ile Lys Lys Lys Asp Ser
Thr Lys Trp Arg Lys Leu 565 570 575Val Asp Phe Arg Glu Leu Asn Lys
Arg Thr Gln Asp Phe Trp Glu Val 580 585 590Gln Leu Gly Ile Pro His
Pro Ala Gly Leu Lys Lys Lys Lys Ser Val 595 600 605Thr Val Leu Asp
Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu 610 615 620Gly Phe
Arg Lys Tyr Thr Ala Phe Thr Ile Pro Ser Thr Asn Asn Glu625 630 635
640Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys
645 650 655Gly Ser Pro Ala Ile Phe Gln Cys Ser Met Thr Arg Ile Leu
Glu Pro 660 665 670Phe Arg Ala Lys Asn Pro Glu Ile Val Ile Tyr Gln
Tyr Met Asp His 675 680 685Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly
Gln His Arg Ala Lys Ile 690 695 700Glu Glu Leu Arg Glu His Leu Leu
Lys Trp Gly Phe Thr Thr Pro Asp705 710 715 720Lys Lys His Gln Lys
Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu 725 730 735His Pro Asp
Lys Trp Thr Val Gln Pro Ile Gln Leu Pro Glu Lys Asp 740 745 750Ser
Trp Thr Val Asn Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp 755 760
765Ala Ser Gln Ile Tyr Pro Gly Ile Lys Val Arg Gln Leu Cys Lys Leu
770 775 780Leu Arg Gly Ala Lys Ala Leu Thr Asp Ile Val Pro Leu Thr
Glu Glu785 790 795 800Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile
Leu Lys Glu Pro Val 805 810 815His Gly Val Tyr Tyr Asp Pro Ser Lys
Asp Leu Ile Ala Glu Ile Gln 820 825 830Lys Gln Gly His Asp Gln Trp
Thr Tyr Gln Ile Tyr Gln Glu Pro Phe 835 840 845Lys Asn Leu Lys Thr
Gly Lys Tyr Ala Lys Met Arg Thr Ala His Thr 850 855 860Asn Asp Val
Lys Gln Leu Thr Glu Ala Val Gln Lys Ile Ala Met Glu865 870 875
880Ser Ile Val Ile Trp Gly Lys Thr Pro Lys Phe Arg Leu Pro Ile Gln
885 890 895Lys Glu Thr Trp Glu Thr Trp Trp Thr Asp Tyr Trp Gln Ala
Thr Trp 900 905 910Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro Leu
Val Lys Leu Trp 915 920 925Tyr Gln Leu Glu Lys Asp Pro Ile Ala Gly
Val Glu Thr Phe Tyr Val 930 935 940Asp Gly Ala Ala Asn Arg Glu Thr
Lys Leu Gly Lys Ala Gly Tyr Val945 950 955 960Thr Asp Arg Gly Arg
Gln Lys Ile Val Ser Leu Thr Glu Thr Thr Asn 965 970 975Gln Lys Thr
Glu Leu Gln Ala Ile Tyr Leu Ala Leu Gln Asp Ser Gly 980 985 990Ser
Glu Val Asn Ile Val Thr Asp Ser Gln Tyr Ala Leu Gly Ile Ile 995
1000 1005Gln Ala Gln Pro Asp Lys Ser Glu Ser Glu Leu Val Asn Gln
Ile 1010 1015 1020Ile Glu Gln Leu Ile Lys Lys Glu Arg Val Tyr Leu
Ser Trp Val 1025 1030 1035Pro Ala His Lys Gly Ile Gly Gly Asn Glu
Gln Val Asp Lys Leu 1040 1045 1050Val Ser Ser Gly Ile Arg Lys Val
Leu Phe Leu Asp Gly Ile Asp 1055 1060 1065Lys Ala Gln Glu Glu His
Glu Lys Tyr His Ser Asn Trp Arg Ala 1070 1075 1080Met Ala Ser Asp
Phe Asn Leu Pro Pro Val Val Ala Lys Glu Ile 1085 1090 1095Val Ala
Ser Cys Asp Gln Cys Gln Leu Lys Gly Glu Ala Met His 1100 1105
1110Gly Gln Val Asp Cys Ser Pro Gly Ile Trp Gln Leu Ala Cys Thr
1115 1120 1125His Leu Glu Gly Lys Ile Ile Leu Val Ala Val His Val
Ala Ser 1130 1135 1140Gly Tyr Ile Glu Ala Glu Val Ile Pro Ala Glu
Thr Gly Gln Glu 1145 1150 1155Thr Ala Tyr Phe Ile Leu Lys Leu Ala
Gly Arg Trp Pro Val Lys 1160 1165 1170Val Ile His Thr Asp Asn Gly
Ser Asn Phe Thr Ser Ala Ala Val 1175 1180 1185Lys Ala Ala Cys Trp
Trp Ala Gly Ile Gln Gln Glu Phe Gly Ile 1190 1195 1200Pro Tyr Asn
Pro Gln Ser Gln Gly Val Val Glu Ser Met Asn Lys 1205 1210 1215Glu
Leu Lys Lys Ile Ile Gly Gln Val Arg Asp Gln Ala Glu His 1220 1225
1230Leu Lys Thr Ala Val Gln Met Ala Val Phe Ile His Asn Phe Lys
1235 1240 1245Arg Lys Gly Gly Ile Gly Gly Tyr Ser Ala Gly Glu Arg
Ile Ile 1250 1255 1260Asp Ile Ile Ala Thr Asp Ile Gln Thr Lys Glu
Leu Gln Lys Gln 1265 1270 1275Ile Ile Lys Ile Gln Asn Phe Arg Val
Tyr Tyr Arg Asp Ser Arg 1280 1285 1290Asp Pro Ile Trp Lys Gly Pro
Ala Lys Leu Leu Trp Lys Gly Glu 1295 1300 1305Gly Ala Val Val Ile
Gln Asp Asn Ser Asp Ile Lys Val Val Pro 1310 1315 1320Arg Arg Lys
Val Lys Ile Ile Lys Asp Tyr Gly Lys Gln Met Ala 1325 1330 1335Gly
Ala Asp Cys Val Ala Gly Arg Gln Asp Glu Asp 1340 1345
1350301341PRTArtificial SequenceSynthetic Construct (Mosaic gagpol2
v5) 30Met Gly Ala Arg Ala Ser Ile Leu Arg Gly Gly Lys Leu Asp Lys
Trp1 5 10 15Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys His Tyr Met
Leu Lys 20 25 30His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala
Leu Asn Pro 35 40 45Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile
Ile Lys Gln Leu 50 55 60Gln Pro Ala Leu Gln Thr Gly Thr Glu Glu Leu
Arg Ser Leu Phe Asn65 70 75 80Thr Val Ala Thr Leu Tyr Cys Val His
Ala Glu Ile Glu Val Arg Asp 85 90 95Thr Lys Glu Ala Leu Asp Lys Ile
Glu Glu Glu Gln Asn Lys Ser Gln 100 105 110Gln Lys Thr Gln Gln Ala
Lys Glu Ala Asp Gly Lys Val Ser Gln Asn 115 120 125Tyr Pro Ile Val
Gln Asn Leu Gln Gly Gln Met Val His Gln Pro Ile 130 135 140Ser Pro
Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu Lys Ala145 150 155
160Phe Ser Pro Glu Val Ile Pro Met Phe Thr Ala Leu Ser Glu Gly Ala
165 170 175Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly
His Gln 180 185 190Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu
Glu Ala Ala Glu 195 200 205Trp Asp Arg Leu His Pro Val His Ala Gly
Pro Val Ala Pro Gly Gln 210 215 220Met Arg Glu Pro Arg Gly Ser Asp
Ile Ala Gly Thr Thr Ser Asn Leu225 230 235 240Gln Glu Gln Ile Ala
Trp Met Thr Ser Asn Pro Pro Ile Pro Val Gly 245 250 255Asp Ile Tyr
Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg 260 265 270Met
Tyr Ser Pro Thr Ser Ile Leu Asp Ile Lys Gln Gly Pro Lys Glu 275 280
285Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg Ala Glu
290 295 300Gln Ala Thr Gln Asp Val Lys Asn Trp Met Thr Asp Thr Leu
Leu Val305 310 315 320Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu
Arg Ala Leu Gly Pro 325 330 335Gly Ala Thr Leu Glu Glu Met Met Thr
Ala Cys Gln Gly Val Gly Gly 340 345 350Pro Ser His Lys Ala Arg Val
Leu Ala Glu Ala Met Ser Gln Thr Asn 355 360 365Ser Thr Ile Leu Met
Gln Arg Ser Asn Phe Lys Gly Ser Lys Arg Ile 370 375 380Val Lys Cys
Phe Asn Cys Gly Lys Glu Gly His Ile Ala Arg Asn Cys385 390 395
400Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys Glu Gly His
405 410 415Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly
Lys Ile 420 425 430Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu
Gln Ser Arg Pro 435 440 445Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe
Arg Phe Glu Glu Thr Thr 450 455 460Pro Ala Pro Lys Gln Glu Pro Lys
Asp Arg Glu Pro Leu Thr Ser Leu465 470 475 480Arg Ser Leu Phe Gly
Ser Asp Pro Leu Ser Gln Met Ala Pro Ile Ser 485 490 495Pro Ile Glu
Thr Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly Pro 500 505 510Lys
Val Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Val 515 520
525Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly
530 535 540Pro Glu Asn Pro Tyr Asn Thr Pro Ile Phe Ala Ile Lys Lys
Lys Asp545 550 555 560Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg
Glu Leu Asn Lys Arg 565 570 575Thr Gln Asp Phe Trp Glu Val Gln Leu
Gly Ile Pro His Pro Ala Gly 580 585 590Leu Lys Lys Lys Lys Ser Val
Thr Val Leu Asp Val Gly Asp Ala Tyr 595 600 605Phe Ser Val Pro Leu
Asp Glu Asp Phe Arg Lys Tyr Thr Ala Phe Thr 610 615 620Ile Pro Ser
Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn625 630 635
640Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Ser Ser
645 650 655Met Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro Asp
Ile Val 660 665 670Ile Tyr Gln Tyr Met Asp His Leu Tyr Val Gly Ser
Asp Leu Glu Ile 675 680 685Gly Gln His Arg Thr Lys Ile Glu Glu Leu
Arg Gln His Leu Leu Arg 690 695 700Trp Gly Phe Thr Thr Pro Asp Lys
Lys His Gln Lys Glu Pro Pro Phe705 710 715 720Leu Trp Met Gly Tyr
Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro 725 730 735Ile Val Leu
Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys 740 745 750Leu
Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys 755 760
765Val Lys Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu Thr Glu
770 775 780Val Val Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu
Asn Arg785 790 795 800Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr
Tyr Asp Pro Ser Lys 805 810 815Asp Leu Ile Ala Glu Ile Gln Lys Gln
Gly Gln Gly Gln Trp Thr Tyr 820 825 830Gln Ile Tyr Gln Glu Pro Phe
Lys Asn Leu Lys Thr Gly Lys Tyr Ala 835 840 845Arg Met Arg Gly Ala
His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala 850 855 860Val Gln Lys
Ile Ala Thr Glu Ser Ile Val Ile Trp Gly Lys Thr Pro865 870 875
880Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Ala Trp Trp Thr
885 890 895Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe Val
Asn Thr 900 905 910Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys
Glu Pro Ile Val 915 920 925Gly Ala Glu Thr Phe Tyr Val Asp Gly Ala
Ala Asn Arg Glu Thr Lys 930 935 940Leu Gly Lys Ala Gly Tyr Val Thr
Asp Arg Gly Arg Gln Lys Val Val945 950 955 960Ser Leu Thr Asp Thr
Thr Asn Gln Lys Thr Glu Leu Gln Ala Ile His 965 970 975Leu Ala Leu
Gln Asp Ser Gly Leu Glu Val Asn Ile Val Thr Asp Ser 980 985 990Gln
Tyr Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Lys Ser Glu Ser 995
1000 1005Glu Leu Val Ser Gln Ile Ile Glu Gln Leu Ile Lys Lys Glu
Lys 1010 1015 1020Val Tyr Leu Ala Trp Val Pro Ala His Lys Gly Ile
Gly Gly Asn 1025 1030 1035Glu Gln Val Asp Lys Leu Val Ser Arg Gly
Ile Arg Lys Val Leu 1040 1045 1050Phe Leu Asp Gly Ile Asp Lys Ala
Gln Glu Glu His Glu Lys Tyr 1055 1060 1065His Ser Asn Trp Arg Ala
Met Ala Ser Glu Phe Asn Leu Pro Pro 1070 1075 1080Ile Val Ala Lys
Glu Ile Val Ala Ser Cys Asp Lys Cys Gln Leu 1085 1090 1095Lys Gly
Glu Ala Ile His Gly Gln Val Asp Cys Ser Pro Gly Ile 1100 1105
1110Trp Gln Leu Ala Cys Thr His Leu Glu Gly Lys Val Ile Leu Val
1115 1120 1125Ala Val His Val Ala Ser Gly Tyr Ile Glu Ala Glu Val
Ile Pro 1130 1135 1140Ala Glu Thr Gly Gln Glu Thr Ala Tyr Phe Leu
Leu Lys Leu Ala 1145 1150 1155Gly Arg Trp Pro Val Lys Thr Ile His
Thr Asp Asn Gly Ser Asn 1160 1165 1170Phe Thr Ser Ala Thr Val Lys
Ala Ala Cys Trp Trp Ala Gly Ile 1175 1180 1185Lys Gln Glu Phe Gly
Ile Pro Tyr Asn Pro Gln Ser Gln Gly Val 1190 1195 1200Val Glu Ser
Ile Asn Lys Glu Leu Lys Lys Ile Ile Gly Gln Val 1205 1210 1215Arg
Asp Gln Ala Glu His Leu Lys Thr Ala Val Gln Met Ala Val 1220 1225
1230Phe Ile His Asn Phe Lys Arg Lys Gly Gly Ile Gly Glu Tyr Ser
1235 1240 1245Ala Gly Glu Arg Ile Val Asp Ile Ile Ala Ser Asp Ile
Gln Thr 1250 1255 1260Lys Glu Leu Gln Lys Gln Ile Thr Lys Ile Gln
Asn Phe Arg Val 1265 1270 1275Tyr Tyr Arg Asp Ser Arg Asp Pro Leu
Trp Lys Gly Pro Ala Lys 1280 1285 1290Leu Leu Trp Lys Gly Glu Gly
Ala Val Val Ile Gln Asp Asn Ser 1295 1300 1305Asp Ile Lys Val Val
Pro Arg Arg Lys Ala Lys Ile Ile Arg Asp 1310 1315 1320Tyr Gly Lys
Gln Met Ala Gly Asp Asp Cys Val Ala Ser Arg Gln 1325 1330 1335Asp
Glu Asp 1340311556PRTArtificial SequenceSynthetic Construct (Mosaic
gagpolnef1) 31Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu
Asp Arg Trp1 5 10 15Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys
Tyr Arg Leu Lys 20 25 30His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg
Phe Ala Val Asn Pro 35 40 45Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg
Gln Ile Leu Gly Gln Leu 50 55 60Gln Pro Ser Leu Gln Thr Gly Ser Glu
Glu Leu Arg Ser Leu Tyr Asn65 70 75 80Thr Val Ala Thr Leu Tyr Cys
Val His Gln Arg Ile Glu Ile Lys Asp 85 90 95Thr Lys Glu Ala Leu Glu
Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110Lys Lys Ala Gln
Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val 115 120 125Ser Gln
Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 130 135
140Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val
Glu145 150 155 160Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe
Ser Ala Leu Ser 165 170 175Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr
Met Leu Asn Thr Val Gly 180 185 190Gly His Gln Ala Ala Met Gln Met
Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205Ala Ala Glu Trp Asp Arg
Val His Pro Val His Ala Gly Pro Ile Ala 210 215 220Pro Gly Gln Met
Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr225 230 235 240Ser
Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250
255Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys
260 265 270Ile Val Arg Met Tyr
Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285Pro Lys Glu
Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300Arg
Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr305 310
315 320Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys
Ala 325 330 335Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala
Cys Gln Gly 340 345 350Val Gly Gly Pro Gly His Lys Ala Arg Val Leu
Ala Glu Ala Met Ser 355 360 365Gln Val Thr Asn Ser Ala Thr Ile Met
Met Gln Arg Gly Asn Phe Arg 370 375 380Asn Gln Arg Lys Thr Val Lys
Cys Phe Asn Cys Gly Lys Glu Gly His385 390 395 400Ile Ala Lys Asn
Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 405 410 415Gly Lys
Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 420 425
430Phe Leu Gly Lys Ile Trp Pro Ser Asn Lys Gly Arg Pro Gly Asn Phe
435 440 445Leu Gln Asn Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser
Phe Arg 450 455 460Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln
Glu Pro Ile Asp465 470 475 480Lys Glu Met Tyr Pro Leu Ala Ser Leu
Lys Ser Leu Phe Gly Asn Asp 485 490 495Pro Ser Ser Gln Met Ala Pro
Ile Ser Pro Ile Glu Thr Val Pro Val 500 505 510Lys Leu Lys Pro Gly
Met Asp Gly Pro Arg Val Lys Gln Trp Pro Leu 515 520 525Thr Glu Glu
Lys Ile Lys Ala Leu Thr Ala Ile Cys Glu Glu Met Glu 530 535 540Lys
Glu Gly Lys Ile Thr Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr545 550
555 560Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys
Leu 565 570 575Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln Asp Phe
Trp Glu Val 580 585 590Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys
Lys Lys Lys Ser Val 595 600 605Thr Val Leu Ala Val Gly Asp Ala Tyr
Phe Ser Val Pro Leu Asp Glu 610 615 620Gly Phe Arg Lys Tyr Thr Ala
Phe Thr Ile Pro Ser Thr Asn Asn Glu625 630 635 640Thr Pro Gly Ile
Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys 645 650 655Gly Ser
Pro Ala Ile Phe Gln Cys Ser Met Thr Arg Ile Leu Glu Pro 660 665
670Phe Arg Ala Lys Asn Pro Glu Ile Val Ile Tyr Gln Tyr Met Ala Ala
675 680 685Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln His Arg Ala
Lys Ile 690 695 700Glu Glu Leu Arg Glu His Leu Leu Lys Trp Gly Phe
Thr Thr Pro Asp705 710 715 720Lys Lys His Gln Lys Glu Pro Pro Phe
Leu Trp Met Gly Tyr Glu Leu 725 730 735His Pro Asp Lys Trp Thr Val
Gln Pro Ile Gln Leu Pro Glu Lys Asp 740 745 750Ser Trp Thr Val Asn
Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp 755 760 765Ala Ser Gln
Ile Tyr Pro Gly Ile Lys Val Arg Gln Leu Cys Lys Leu 770 775 780Leu
Arg Gly Ala Lys Ala Leu Thr Asp Ile Val Pro Leu Thr Glu Glu785 790
795 800Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile Leu Lys Glu Pro
Val 805 810 815His Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu Ile Ala
Glu Ile Gln 820 825 830Lys Gln Gly His Asp Gln Trp Thr Tyr Gln Ile
Tyr Gln Glu Pro Phe 835 840 845Lys Asn Leu Lys Thr Gly Lys Tyr Ala
Lys Met Arg Thr Ala His Thr 850 855 860Asn Asp Val Lys Gln Leu Thr
Glu Ala Val Gln Lys Ile Ala Met Glu865 870 875 880Ser Ile Val Ile
Trp Gly Lys Thr Pro Lys Phe Arg Leu Pro Ile Gln 885 890 895Lys Glu
Thr Trp Glu Thr Trp Trp Thr Asp Tyr Trp Gln Ala Thr Trp 900 905
910Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro Leu Val Lys Leu Trp
915 920 925Tyr Gln Leu Glu Lys Asp Pro Ile Ala Gly Val Glu Thr Phe
Tyr Val 930 935 940Ala Gly Ala Ala Asn Arg Glu Thr Lys Leu Gly Lys
Ala Gly Tyr Val945 950 955 960Thr Asp Arg Gly Arg Gln Lys Ile Val
Ser Leu Thr Glu Thr Thr Asn 965 970 975Gln Lys Thr Ala Leu Gln Ala
Ile Tyr Leu Ala Leu Gln Asp Ser Gly 980 985 990Ser Glu Val Asn Ile
Val Thr Ala Ser Gln Tyr Ala Leu Gly Ile Ile 995 1000 1005Gln Ala
Gln Pro Asp Lys Ser Glu Ser Glu Leu Val Asn Gln Ile 1010 1015
1020Ile Glu Gln Leu Ile Lys Lys Glu Arg Val Tyr Leu Ser Trp Val
1025 1030 1035Pro Ala His Lys Gly Ile Gly Gly Asn Glu Gln Val Asp
Lys Leu 1040 1045 1050Val Ser Ser Gly Ile Arg Lys Val Leu Phe Leu
Asp Gly Ile Asp 1055 1060 1065Lys Ala Gln Glu Glu His Glu Lys Tyr
His Ser Asn Trp Arg Ala 1070 1075 1080Met Ala Ser Asp Phe Asn Leu
Pro Pro Val Val Ala Lys Glu Ile 1085 1090 1095Val Ala Ser Cys Asp
Gln Cys Gln Leu Lys Gly Glu Ala Met His 1100 1105 1110Gly Gln Val
Asp Cys Ser Pro Gly Ile Trp Gln Leu Ala Cys Thr 1115 1120 1125His
Leu Glu Gly Lys Ile Ile Leu Val Ala Val His Val Ala Ser 1130 1135
1140Gly Tyr Ile Glu Ala Glu Val Ile Pro Ala Glu Thr Gly Gln Glu
1145 1150 1155Thr Ala Tyr Phe Ile Leu Lys Leu Ala Gly Arg Trp Pro
Val Lys 1160 1165 1170Val Ile His Thr Ala Asn Gly Ser Asn Phe Thr
Ser Ala Ala Val 1175 1180 1185Lys Ala Ala Cys Trp Trp Ala Gly Ile
Gln Gln Glu Phe Gly Ile 1190 1195 1200Pro Tyr Asn Pro Gln Ser Gln
Gly Val Val Ala Ser Met Asn Lys 1205 1210 1215Glu Leu Lys Lys Ile
Ile Gly Gln Val Arg Asp Gln Ala Glu His 1220 1225 1230Leu Lys Thr
Ala Val Gln Met Ala Val Phe Ile His Asn Phe Lys 1235 1240 1245Arg
Lys Gly Gly Ile Gly Gly Tyr Ser Ala Gly Glu Arg Ile Ile 1250 1255
1260Asp Ile Ile Ala Thr Asp Ile Gln Thr Lys Glu Leu Gln Lys Gln
1265 1270 1275Ile Ile Lys Ile Gln Asn Phe Arg Val Tyr Tyr Arg Asp
Ser Arg 1280 1285 1290Asp Pro Ile Trp Lys Gly Pro Ala Lys Leu Leu
Trp Lys Gly Glu 1295 1300 1305Gly Ala Val Val Ile Gln Asp Asn Ser
Asp Ile Lys Val Val Pro 1310 1315 1320Arg Arg Lys Val Lys Ile Ile
Lys Asp Tyr Gly Lys Gln Met Ala 1325 1330 1335Gly Ala Asp Cys Val
Ala Gly Arg Gln Asp Glu Asp Met Ala Gly 1340 1345 1350Lys Trp Ser
Lys Ser Ser Val Val Gly Trp Pro Ala Ile Arg Glu 1355 1360 1365Arg
Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala Val 1370 1375
1380Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr
1385 1390 1395Ala Ala Asn Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln
Glu Glu 1400 1405 1410Glu Glu Val Gly Phe Pro Val Arg Pro Gln Val
Pro Leu Arg Pro 1415 1420 1425Met Thr Tyr Lys Gly Ala Leu Asp Leu
Ser His Phe Leu Lys Glu 1430 1435 1440Lys Gly Gly Leu Glu Gly Leu
Ile Tyr Ser Gln Lys Arg Gln Asp 1445 1450 1455Ile Leu Asp Leu Trp
Val Tyr His Thr Gln Gly Tyr Phe Pro Asp 1460 1465 1470Trp Gln Asn
Tyr Thr Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr 1475 1480 1485Phe
Gly Trp Cys Phe Lys Leu Val Pro Val Glu Pro Glu Lys Ile 1490 1495
1500Glu Glu Ala Asn Glu Gly Glu Asn Asn Ser Leu Leu His Pro Met
1505 1510 1515Ser Gln His Gly Met Asp Asp Pro Glu Lys Glu Val Leu
Met Trp 1520 1525 1530Lys Phe Asp Ser Arg Leu Ala Phe His His Met
Ala Arg Glu Leu 1535 1540 1545His Pro Glu Tyr Tyr Lys Asp Cys 1550
1555321547PRTArtificial SequenceSynthetic Construct (Mosaic
gagpolnef2) 32Met Gly Ala Arg Ala Ser Ile Leu Arg Gly Gly Lys Leu
Asp Lys Trp1 5 10 15Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys His
Tyr Met Leu Lys 20 25 30His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg
Phe Ala Leu Asn Pro 35 40 45Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys
Gln Ile Ile Lys Gln Leu 50 55 60Gln Pro Ala Leu Gln Thr Gly Thr Glu
Glu Leu Arg Ser Leu Phe Asn65 70 75 80Thr Val Ala Thr Leu Tyr Cys
Val His Ala Glu Ile Glu Val Arg Asp 85 90 95Thr Lys Glu Ala Leu Asp
Lys Ile Glu Glu Glu Gln Asn Lys Ser Gln 100 105 110Gln Lys Thr Gln
Gln Ala Lys Glu Ala Asp Gly Lys Val Ser Gln Asn 115 120 125Tyr Pro
Ile Val Gln Asn Leu Gln Gly Gln Met Val His Gln Pro Ile 130 135
140Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu Lys
Ala145 150 155 160Phe Ser Pro Glu Val Ile Pro Met Phe Thr Ala Leu
Ser Glu Gly Ala 165 170 175Thr Pro Gln Asp Leu Asn Thr Met Leu Asn
Thr Val Gly Gly His Gln 180 185 190Ala Ala Met Gln Met Leu Lys Asp
Thr Ile Asn Glu Glu Ala Ala Glu 195 200 205Trp Asp Arg Leu His Pro
Val His Ala Gly Pro Val Ala Pro Gly Gln 210 215 220Met Arg Glu Pro
Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Asn Leu225 230 235 240Gln
Glu Gln Ile Ala Trp Met Thr Ser Asn Pro Pro Ile Pro Val Gly 245 250
255Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg
260 265 270Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Lys Gln Gly Pro
Lys Glu 275 280 285Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr
Leu Arg Ala Glu 290 295 300Gln Ala Thr Gln Asp Val Lys Asn Trp Met
Thr Asp Thr Leu Leu Val305 310 315 320Gln Asn Ala Asn Pro Asp Cys
Lys Thr Ile Leu Arg Ala Leu Gly Pro 325 330 335Gly Ala Thr Leu Glu
Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly 340 345 350Pro Ser His
Lys Ala Arg Val Leu Ala Glu Ala Met Ser Gln Thr Asn 355 360 365Ser
Thr Ile Leu Met Gln Arg Ser Asn Phe Lys Gly Ser Lys Arg Ile 370 375
380Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His Ile Ala Arg Asn
Cys385 390 395 400Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly
Lys Glu Gly His 405 410 415Gln Met Lys Asp Cys Thr Glu Arg Gln Ala
Asn Phe Leu Gly Lys Ile 420 425 430Trp Pro Ser His Lys Gly Arg Pro
Gly Asn Phe Leu Gln Ser Arg Pro 435 440 445Glu Pro Thr Ala Pro Pro
Ala Glu Ser Phe Arg Phe Glu Glu Thr Thr 450 455 460Pro Ala Pro Lys
Gln Glu Pro Lys Asp Arg Glu Pro Leu Thr Ser Leu465 470 475 480Arg
Ser Leu Phe Gly Ser Asp Pro Leu Ser Gln Met Ala Pro Ile Ser 485 490
495Pro Ile Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly Pro
500 505 510Lys Val Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala
Leu Val 515 520 525Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile
Ser Lys Ile Gly 530 535 540Pro Glu Asn Pro Tyr Asn Thr Pro Ile Phe
Ala Ile Lys Lys Lys Asp545 550 555 560Ser Thr Lys Trp Arg Lys Leu
Val Asp Phe Arg Glu Leu Asn Lys Arg 565 570 575Thr Gln Asp Phe Trp
Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly 580 585 590Leu Lys Lys
Lys Lys Ser Val Thr Val Leu Ala Val Gly Asp Ala Tyr 595 600 605Phe
Ser Val Pro Leu Asp Glu Asp Phe Arg Lys Tyr Thr Ala Phe Thr 610 615
620Ile Pro Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr
Asn625 630 635 640Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile
Phe Gln Ser Ser 645 650 655Met Thr Lys Ile Leu Glu Pro Phe Arg Lys
Gln Asn Pro Asp Ile Val 660 665 670Ile Tyr Gln Tyr Met Ala Ala Leu
Tyr Val Gly Ser Asp Leu Glu Ile 675 680 685Gly Gln His Arg Thr Lys
Ile Glu Glu Leu Arg Gln His Leu Leu Arg 690 695 700Trp Gly Phe Thr
Thr Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe705 710 715 720Leu
Trp Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro 725 730
735Ile Val Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys
740 745 750Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly
Ile Lys 755 760 765Val Lys Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys
Ala Leu Thr Glu 770 775 780Val Val Pro Leu Thr Glu Glu Ala Glu Leu
Glu Leu Ala Glu Asn Arg785 790 795 800Glu Ile Leu Lys Glu Pro Val
His Gly Val Tyr Tyr Asp Pro Ser Lys 805 810 815Asp Leu Ile Ala Glu
Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr 820 825 830Gln Ile Tyr
Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala 835 840 845Arg
Met Arg Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala 850 855
860Val Gln Lys Ile Ala Thr Glu Ser Ile Val Ile Trp Gly Lys Thr
Pro865 870 875 880Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu
Ala Trp Trp Thr 885 890 895Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu
Trp Glu Phe Val Asn Thr 900 905 910Pro Pro Leu Val Lys Leu Trp Tyr
Gln Leu Glu Lys Glu Pro Ile Val 915 920 925Gly Ala Glu Thr Phe Tyr
Val Ala Gly Ala Ala Asn Arg Glu Thr Lys 930 935 940Leu Gly Lys Ala
Gly Tyr Val Thr Asp Arg Gly Arg Gln Lys Val Val945 950 955 960Ser
Leu Thr Asp Thr Thr Asn Gln Lys Thr Ala Leu Gln Ala Ile His 965 970
975Leu Ala Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val Thr Ala Ser
980 985 990Gln Tyr Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Lys Ser
Glu Ser 995 1000 1005Glu Leu Val Ser Gln Ile Ile Glu Gln Leu Ile
Lys Lys Glu Lys 1010 1015 1020Val Tyr Leu Ala Trp Val Pro Ala His
Lys Gly Ile Gly Gly Asn 1025 1030 1035Glu Gln Val Asp Lys Leu Val
Ser Arg Gly Ile Arg Lys Val Leu 1040 1045 1050Phe Leu Asp Gly Ile
Asp Lys Ala Gln Glu Glu His Glu Lys Tyr 1055 1060 1065His Ser Asn
Trp Arg Ala Met Ala Ser Glu Phe Asn Leu Pro Pro 1070 1075 1080Ile
Val Ala Lys Glu Ile Val Ala Ser Cys Asp Lys Cys Gln Leu 1085 1090
1095Lys Gly Glu Ala Ile His Gly Gln Val Asp Cys Ser Pro Gly Ile
1100 1105 1110Trp Gln Leu Ala Cys Thr His Leu Glu Gly Lys Val Ile
Leu Val 1115 1120 1125Ala Val His Val Ala Ser Gly Tyr Ile Glu Ala
Glu Val Ile Pro 1130 1135 1140Ala Glu Thr Gly Gln Glu Thr Ala Tyr
Phe Leu Leu Lys Leu Ala 1145 1150 1155Gly Arg Trp Pro Val Lys Thr
Ile His Thr Ala Asn Gly Ser Asn 1160 1165
1170Phe Thr Ser Ala Thr Val Lys Ala Ala Cys Trp Trp Ala Gly Ile
1175 1180 1185Lys Gln Glu Phe Gly Ile Pro Tyr Asn Pro Gln Ser Gln
Gly Val 1190 1195 1200Val Ala Ser Ile Asn Lys Glu Leu Lys Lys Ile
Ile Gly Gln Val 1205 1210 1215Arg Asp Gln Ala Glu His Leu Lys Thr
Ala Val Gln Met Ala Val 1220 1225 1230Phe Ile His Asn Phe Lys Arg
Lys Gly Gly Ile Gly Glu Tyr Ser 1235 1240 1245Ala Gly Glu Arg Ile
Val Asp Ile Ile Ala Ser Asp Ile Gln Thr 1250 1255 1260Lys Glu Leu
Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg Val 1265 1270 1275Tyr
Tyr Arg Asp Ser Arg Asp Pro Leu Trp Lys Gly Pro Ala Lys 1280 1285
1290Leu Leu Trp Lys Gly Glu Gly Ala Val Val Ile Gln Asp Asn Ser
1295 1300 1305Asp Ile Lys Val Val Pro Arg Arg Lys Ala Lys Ile Ile
Arg Asp 1310 1315 1320Tyr Gly Lys Gln Met Ala Gly Asp Asp Cys Val
Ala Ser Arg Gln 1325 1330 1335Asp Glu Asp Met Ala Gly Lys Trp Ser
Lys Ser Ser Ile Val Gly 1340 1345 1350Trp Pro Ala Val Arg Glu Arg
Ile Arg Arg Ala Glu Pro Ala Ala 1355 1360 1365Glu Gly Val Gly Ala
Ala Ser Gln Asp Leu Asp Lys Tyr Gly Ala 1370 1375 1380Leu Thr Ser
Ser Asn Thr Ala Ala Thr Asn Ala Asp Cys Ala Trp 1385 1390 1395Leu
Glu Ala Gln Glu Asp Glu Glu Val Gly Phe Pro Val Lys Pro 1400 1405
1410Gln Val Pro Leu Arg Pro Met Thr Tyr Lys Ala Ala Phe Asp Leu
1415 1420 1425Ser Phe Phe Leu Lys Glu Lys Gly Gly Leu Asp Gly Leu
Ile Tyr 1430 1435 1440Ser Lys Lys Arg Gln Glu Ile Leu Asp Leu Trp
Val Tyr Asn Thr 1445 1450 1455Gln Gly Phe Phe Pro Asp Trp Gln Asn
Tyr Thr Pro Gly Pro Gly 1460 1465 1470Val Arg Tyr Pro Leu Thr Phe
Gly Trp Cys Phe Lys Leu Val Pro 1475 1480 1485Val Asp Pro Arg Glu
Val Glu Glu Ala Asn Lys Gly Glu Asn Asn 1490 1495 1500Cys Leu Leu
His Pro Met Asn Leu His Gly Met Asp Asp Pro Glu 1505 1510 1515Arg
Glu Val Leu Val Trp Arg Phe Asp Ser Arg Leu Ala Phe His 1520 1525
1530His Met Ala Arg Glu Lys His Pro Glu Tyr Tyr Lys Asn Cys 1535
1540 1545
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