U.S. patent application number 17/250446 was filed with the patent office on 2021-10-14 for cryoablation apparatus and method.
This patent application is currently assigned to PIEDMONT MEDSYSTEMS (ZHUHAI) CO., LTD.. The applicant listed for this patent is PIEDMONT MEDSYSTEMS (ZHUHAI) CO., LTD.. Invention is credited to Alan De La Rama, Cary Kunihiko Hata, Dongbo Su, Jiahua Xiao.
Application Number | 20210315626 17/250446 |
Document ID | / |
Family ID | 1000005705901 |
Filed Date | 2021-10-14 |
United States Patent
Application |
20210315626 |
Kind Code |
A1 |
Xiao; Jiahua ; et
al. |
October 14, 2021 |
CRYOABLATION APPARATUS AND METHOD
Abstract
A cryoablation device comprises a freezing balloon, a catheter,
a storage tank, a delivery pipeline, a recovery pipeline, and a
freezing element. Within the freezing balloon circulates a freezing
substance, such as a low pressure liquid or gas or a gas-liquid
mixture. A cryoablation method comprises the following four steps:
pre-freezing, ablation, recovery, and rewarming. Advantages of the
cryoablation device and method provided herein: low risk factor,
easy to operate, convenient to use, exhibits high freezing
efficiency, and temperature control accuracy.
Inventors: |
Xiao; Jiahua; (Zhuhai,
Guangdong, CN) ; Su; Dongbo; (Zhuhai, Guangdong,
CN) ; De La Rama; Alan; (Zhuhai, Guangdong, CN)
; Hata; Cary Kunihiko; (Zhuhai, Guangdong, CN) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
PIEDMONT MEDSYSTEMS (ZHUHAI) CO., LTD. |
Zhuhai, Guangdong |
|
CN |
|
|
Assignee: |
PIEDMONT MEDSYSTEMS (ZHUHAI) CO.,
LTD.
Zhuhai, Guangdong
CN
|
Family ID: |
1000005705901 |
Appl. No.: |
17/250446 |
Filed: |
August 1, 2018 |
PCT Filed: |
August 1, 2018 |
PCT NO: |
PCT/CN2018/097905 |
371 Date: |
January 22, 2021 |
Current U.S.
Class: |
1/1 |
Current CPC
Class: |
A61B 2018/0022 20130101;
A61B 2018/0212 20130101; A61B 2018/0262 20130101; A61B 2018/00577
20130101; A61B 18/02 20130101; A61B 2018/00714 20130101 |
International
Class: |
A61B 18/02 20060101
A61B018/02 |
Foreign Application Data
Date |
Code |
Application Number |
Jul 23, 2018 |
CN |
201810812250.3 |
Claims
1-21. (canceled)
22. A cryoablation apparatus comprising: a cryoballoon, provided
with a circulating cold carrier medium therein, and adapted for
contacting a human tissue and performing cryoablation on the human
tissue; a catheter, connected to the cryoballoon, having an inlet
end and an outlet end, and adapted for transporting the cold
carrier medium into and out of the cryoballoon; a storage tank,
provided with the cold carrier medium stored therein; a delivery
pipeline, having one end communicated with the storage tank and
another end communicated with the inlet end of the catheter; a
recovery pipeline, having one end communicated with the storage
tank and another end communicated with the outlet end of the
catheter; and a refrigeration assembly, connected in series with
the delivery pipeline, and adapted for cooling the cold carrier
medium in the delivery pipeline.
23. The cryoablation apparatus of claim 22 wherein the
refrigeration assembly comprises: a first cold energy exchanger,
mounted on the delivery pipeline and used for cooling the cold
carrier medium flowing through the first cold energy exchanger by
heat exchange; and a cold energy generator, for generating cold
energy and providing the cold energy to the first cold energy
exchanger.
24. The cryoablation apparatus of claim 23 further comprising a
bypass pipe communicated with the delivery pipeline and the
recovery pipeline to allow the delivery pipeline and the recovery
pipeline to form a precooling looping path connecting the storage
tank and the first cold energy exchanger in series, wherein the
bypass pipe is communicated with the delivery pipeline via a first
three-way valve.
25. The cryoablation apparatus of claim 23 wherein the
refrigeration assembly further comprises a second cold energy
exchanger having a hot fluid channel mounted on the delivery
pipeline and a cold fluid channel mounted on the recovery pipeline,
wherein cold energy exchange occurs between the cold fluid channel
and the hot fluid channel to precool the cold carrier medium
flowing through the hot fluid channel, and wherein the hot fluid
channel is connected between the storage tank and the first cold
energy exchanger.
26. The cryoablation apparatus of claim 25 wherein the
refrigeration assembly further comprises a cold storage device,
mounted on the recovery pipeline, communicated with the first cold
energy exchanger via the bypass pipe, and adapted for storing cold
energy coming from the first cold energy exchanger.
27. The cryoablation apparatus of claim 26 wherein the
refrigeration assembly further comprises a heat-insulation device,
having a heat-insulation chamber adapted for reducing or
eliminating heat conduction to the exterior thereof, wherein the
first cold energy exchanger, the second cold energy exchanger, the
cold storage device, and a cold energy output end of the cold
energy generator are located inside the heat-insulation
chamber.
28. The cryoablation apparatus of claim 27 wherein the
heat-insulation device is a box mounted with a vacuumizing device
communicated with the heat-insulation chamber.
29. The cryoablation apparatus of claim 27 wherein the
heat-insulation device is a box with the heat-insulation chamber
thereof filled with heat insulation substance.
30. The cryoablation apparatus of claim 23 further comprising a
rewarming looping path for transporting the cold carrier medium in
the storage tank to the inlet end of the catheter of the
cryoablation apparatus.
31. The cryoablation apparatus of claim 30 wherein the rewarming
looping path comprises a rewarming pipe, and wherein an inlet end
of the rewarming pipe is connected by a second three-way valve to a
side of the delivery pipeline that is located upstream of the first
cold energy exchanger.
32. The cryoablation apparatus of claim 23 further comprising a
rewarming looping path for transporting the cold carrier medium in
the storage tank to the inlet end of the catheter of the
cryoablation apparatus after heating the cold carrier medium.
33. The cryoablation apparatus of claim 32 wherein the rewarming
looping path comprises a rewarming pipe with a heating device
connected in series, and wherein an inlet end of the rewarming pipe
is connected by a second three-way valve to an upstream side of an
inlet to the hot fluid channel.
34. The cryoablation apparatus of claim 30 wherein the rewarming
looping path also comprises a rewarming backflow pipeline for
connecting the outlet end of the catheter of the cryoablation
apparatus to the storage tank.
35. The cryoablation apparatus of claim 34 wherein the rewarming
backflow pipeline comprises a rewarming backflow pipe having both
ends thereof communicated with the recovery pipeline and being
connected in parallel to the second cold energy exchanger, and
wherein an inlet of the rewarming backflow pipe is connected by a
third three-way valve to the delivery pipeline.
36. The cryoablation apparatus of claim 35 wherein the
refrigeration assembly further comprises a heat-insulation device
having a heat-insulation chamber adapted for reducing or
eliminating heat conduction to the exterior thereof, wherein the
first cold energy exchanger, the second cold energy exchanger, a
cold storage device, and a cold energy output end of the cold
energy generator are located inside the heat-insulation chamber,
and wherein the rewarming backflow pipe is located outside the
heat-insulation device.
37. A cryoablation method comprising: a precooling step, in which a
cold carrier medium is circulated through a cold energy generator
for cooling; an ablating step, in which the precooled cold carrier
medium is re-circulated through the cold energy generator for
re-cooling and then is transported to a target tissue of a human
body, so that cold energy exchange occurs between the cold carrier
medium and the target tissue to cool the target tissue for
cryoablation of the target tissue; a recovering step, in which the
cold carrier medium after cold energy exchange with the target
tissue is transported out of the human body and into a storage
tank; and a rewarming step, in which the transportation of the
cooled cold carrier medium into the human body is stopped, and the
target tissue is rewarmed.
38. The cryoablation method of claim 37 wherein, in the recovering
step, the cold carrier medium after cold energy exchange with the
target tissue is transported out of the human body, and residual
cold energy in the cold carrier medium transported out of the human
body is utilized to carry out cold energy exchange with the cold
carrier medium flowing out of the storage tank at a second cold
energy exchanger, so as to cause the cold carrier medium before
entry into the first cold energy exchanger to be cooled and then
transported into the first cold energy exchanger.
39. The cryoablation method of claim 37 wherein a part of cold
energy is stored in the precooling stage, and then transferred to
the cold carrier medium recovered from a catheter, so as to be
exchanged to the cold carrier medium flowing out of the storage
tank at a second cold energy exchanger.
40. The cryoablation method of claim 37 wherein, in the rewarming
step, the cold carrier medium is circulated through a heating
device for being warmed, and then the cold carrier medium after
being warmed is transported to the target tissue of the human body,
so as to warm the cooled target tissue by heat exchange between the
cold carrier medium and the target tissue.
41. The cryoablation method of claim 37 wherein, in the rewarming
step, uncooled cold carrier medium is transported to the human
body, so as to warm the target tissue by heat exchange between the
uncooled cold carrier medium and the target tissue.
Description
[0001] This application is the National Stage of, and therefore
claims the benefit of and priority to, International Application
No. PCT/CN2018/097905, filed on Aug. 1, 2018, entitled
"Cryoablation Apparatus and Cryoablation Method," which was
published as International Publication No. WO 2020/019362 A1 on
Jan. 30, 2020, and has a priority date of Jul 23, 2018, based on
Chinese Patent Application No. CN 201810812250. Both of the above
applications are commonly assigned with this National Stage
application, and the entireties thereof are hereby incorporated
herein by reference.
TECHNICAL FIELD
[0002] The present invention relates to the technical field of
medical equipment, in particular to a cryoablation device and a
cryoablation method.
BACKGROUND TECHNIQUE
[0003] Cryoablation is a surgical medical technique that uses
freezing to eliminate target tissues, and is mostly used to treat
tumors, atrial fibrillation and other diseases. The principle is to
use low-temperature equipment to make the target tissue undergo a
process of cold, freezing, and rewarming, thereby causing
irreversible damage or necrosis to the cells. The cryoablation
equipment generally includes a cryoablation generator (host) and a
cryo-balloon part. The cryo-ablation generator (host) is
responsible for providing cold-carrying medium for the
cryo-balloon. When in use, the cryo-balloon is installed at the tip
of the catheter and extended into the body. The cryoablation
generator (host) passes the cold-carrying medium from the catheter
into the cryo-balloon to cool it down, and then cryoablate the
target tissue.
[0004] The cryoablation generator in the prior art generally adopts
high-pressure gas throttling refrigeration method. When the
high-pressure gas flows through the small hole and then adiabatic
throttling, the temperature tends to change the pressure drops, and
the gas adiabatic throttling is used The effect can complete the
cooling treatment process of cryoablation. However, the
high-pressure gas throttling method has certain defects in actual
use: First, the high-pressure gas has a high risk factor. Since the
cryoablation terminal balloon is generally in the human body, once
the gas pressure is too high, the balloon may rupture, posing a
great safety threat to the patient; secondly, high-pressure gas is
a consumable, which needs to be supplemented and is inconvenient to
use; again, the use of equipment The requirements for the operator
are high, and the operation needs to be accompanied by a
professional technician during the operation.
SUMMARY OF THE INVENTION
[0005] Therefore, the technical problem to be solved by the present
invention is to overcome the defects of high risk factor, fast
working fluid consumption, and inconvenience in use of the
cryoablation device in the prior art, and to provide a low risk
factor, extremely low working fluid loss, Easy to use cryoablation
device.
[0006] Another technical problem to be solved by the present
invention is to overcome the defects of the prior art cryoablation
method of high risk factor and difficulty in operation, and further
provide a cryoablation method with low risk factor and simple
operation.
[0007] In order to solve the above technical problems, the
technical solutions provided by the present invention are as
follows:
[0008] A cryoablation device includes:
[0009] The cryo-balloon, in which a cold medium is circulated, is
suitable for contact with human tissue and cryoablation;
[0010] The catheter, which is watered to the freezing balloon, has
a medium input end and a medium output end, and is suitable for
inputting and outputting cold medium into the freezing balloon;
[0011] Medium storage tank, in which cold medium is stored;
[0012] The medium recovery pipeline, one end is connected with the
medium storage tank, and the other end is connected with the medium
output end of the pipe;
[0013] The refrigeration component is connected in series with the
medium supply pipeline, and is suitable for refrigeration and heat
exchange of the refrigerating medium in the medium supply
pipeline.
[0014] As a preferred technical solution, the refrigeration
assembly includes:
[0015] Cooling capacity generating device, used to generate cooling
capacity:
[0016] The first refrigeration exchange device is installed on the
medium supply pipeline, the refrigeration generating device
provides refrigeration to the first refrigeration exchange device,
and the first refrigeration exchange device is used for The cooling
medium in the quantity exchange device performs refrigeration and
heat exchange;
[0017] As a preferred technical solution, the refrigeration
assembly further includes:
[0018] The second cold quantity exchange device has a hot fluid
passage installed on the medium supply pipe and a cold fluid
passage installed on the medium recovery pipe, and cold energy is
generated between the cold fluid passage and the hot fluid passage
Exchange, pre-cooling the cooling medium flowing through the hot
fluid channel;
[0019] The hot fluid passage is concerted between the medium
storage tank and the first cold quantity exchange device.
[0020] As a preferred technical solution, it also includes:
[0021] A bypass pipe which is connected to the medium supply
pipeline and the medium recovery pipeline, and enables the medium
supply pipeline and the medium recovery pipeline to form a
pre-cooling circuit of the serial medium storage tank and the first
cold capacity exchange device;
[0022] And the bypass pipe and the medium supply pipeline
communicate with each other through a first three-way valve.
[0023] As a preferred technical solution, the refrigeration
assembly further includes:
[0024] The cold storage device is installed on the medium recovery
pipeline, communicates with the first cold energy exchange device
by a bypass pipe and is writable for storing the cold energy
flowing out of the first cold energy exchange device.
[0025] As a preferred technical solution, the refrigeration
assembly further includes:
[0026] The heat insulation device has a heat insulation cavity
suitable for reducing or isolating heat conduction from the
outside, and the cold output ends of the first cold energy exchange
device, the second cold energy exchange device, the cold storage
device and the cold energy generation device are located in the
insolation Hot cavity.
[0027] As a preferred technical solution, the heat insulation
device is a box body, and a vacuum pumping device communicating
with the heat insulation cavity is installed on the heat insulation
device.
[0028] As a preferred technical solution, the heat insulation
device is a box, and the heat insulation cavity is filled with a
heat insulation material
[0029] As a preferred technical solution, it further includes a
reheating circuit for transporting the cold-carrying medium in the
medium storage tank to the medium input end of the catheter in the
cryoablation device.
[0030] As a preferred technical solution, the reheating circuit
includes:
[0031] Rehearing tube
[0032] The medium inlet end of the reheating pipe is concerted with
the side installed on the medium supply pipeline that dons not
enter the first cold quantity exchange device by a second three-way
valve.
[0033] As a preferred technical solution, it further include a
reheating circuit for heating the cold-carrying medium in the
medium storage tank and then delivering it to the medium input end
of the catheter in the cryoablation device.
[0034] As a preferred technical solution, the reheating circuit
includes:
[0035] Reheating tube with a heating device connected in
series;
[0036] The medium inlet end of the reheating pipe is connected with
the upstream of the medium inlet port that enters the hot fluid
channel by a second three-way valve.
[0037] As a preferred technical solution, the reheating circuit
further includes:
[0038] The rewarming return line is used to connect the medium
output end of the catheter in the cryoablation device with the
medium storage tank.
[0039] As a preferred technical solution, the reheating return
pipeline includes:
[0040] The reheating return pipe is connected with the medium
recovery pipeline at both ends, and is connected in parallel with
the second cold capacity exchange device;
[0041] The medium inlet end of the reheating return pipe is
connected with the medium supply pipeline by a third three-way
valve.
[0042] As a preferred technical solution, the refrigeration
assembly further includes:
[0043] The heat insulation device has a heat insulation cavity
suitable for reducing or isolating heat conduction from the
outside, and the cold output ends of the first cold energy exchange
device, the second cold energy exchange device, the cold storage
device and the cold energy generation device are located Hot
cavity
[0044] The rehearing return pipe is outside the heat insulation
device.
[0045] As a preferred technical solution a pumping device is
concerted in series to the medium supply pipeline or the medium
recovery pipeline, and the pumping device is suitable for providing
power for the flow of the cooling medium.
[0046] A cryoablation method includes the following steps:
[0047] Pre-cooling, passing the cooling medium cooling cycle into
the cooling capacity generator for cooling
[0048] Ablation the pre-cooled cold-carrying medium is recirculated
into the cold generation device for cooling again, and then passed
into the target tissue of the human body, so that the cold-carrying
medium and the target tissue can exchange cold, so that the target
Perform cryoablation of the targeted tissue after cooling down the
tissue;
[0049] After rewarming, stop passing the cooled cold carrier medium
into the human body to raise the temperature of the target
tissue.
[0050] In a preferred technical solution, in the recovery step, the
cold-carrying Medium after cold exchange with the target tissue is
transported from the human body, and the remaining cold in the
cold-carrying medium and the carrier flowing out of the medium
storage tank are used. The cooling medium is exchanged in the
second cooling capacity exchange device, so that the cooling medium
that has not yet passed into the first cooling capacity exchange
device is cooled and then transported to the first cooling capacity
exchange device.
[0051] As a preferred technical solution, a part of the cold energy
is stored in the pre cooling stage, and the cold energy is
transferred to the cold carrier medium recovered from the duct, and
flows out of the medium storage tank in the second cold energy
exchange device. The cold carrier medium for cold capacity
exchange.
[0052] As a preferred technical solution, in the rewarming step,
the cooling medium is circuited through the heating device to raise
the temperature of the cooling medium, and then the heated cooling
medium is passed into the target tissue of the human body to make
the cooling medium The medium exchanges heat with the target
tissue, which heats up the target tissue after cooling.
[0053] As a preferred technical solution, in the rewarming step, a
cold carrier that has not been refrigerated is input into the human
body, so that the target tissue and the cold carrier that have not
been refrigerated will heat up after heat exchange.
[0054] The technical scheme of the present intention has the
following advantages:
[0055] 1. The cryoablation device provided by the present invention
includes a cryo-balloon, a catheter, a medium storage tank a medium
supply pipeline, a medium recovery pipeline, and a refrigeration
component; the cryo-balloon is filled with a cold medium, which is
suitable for human tissue Contact and perform cryoablation; the
catheter is connected with the cryo-balloon and has a medium input
end and a medium output end, which is suitable for inputting and
outputting the cold-carrying medium into the freezing balloon; the
cold-carrying medium is stored in the medium storage tank, so The
refrigerating medium is low-pressure liquid or gas or gas-liquid
mixture; one end of the medium supply pipeline is connected with
the medium storage tank, and the other end is connected with the
medium input end of the pipe; one end of the medium recovery pipe
is connected with the medium storage tank, and the other end is
connected with the pipe The medium output end of the medium is
connected; the refrigeration component is connected in series with
the medium supply pipeline, which is suitable for providing cold
energy to the cold medium in the medium supply pipeline. In the
process of cryoablation, the cooling medium flows according to the
following path: after flowing out of the medium storage tank along
the medium supply pipeline, passing through the refrigeration
component, the temperature of the cooling medium drops, and then
enters the medium input end of the catheter. Then it flows into the
freezing balloon to contact the target tissue via the balloon, and
then flows out from the media output end of the catheter to the
media recovery pipeline, and finally returns to the media storage
tank to complete a cycle. In the above process, since the original
high-pressure gas is replaced with a cold-carrying medium, the
cold-carrying medium body is directly cooled and cooled, so that it
can meet the low temperature requirements of freezing and ablation.
Compared with high-pressure gas, the refrigerating medium is less
prone to explosion, so it can effectively reduce the risk factor of
the cryoablation device during use. At the same time, since the
refrigerating medium can be recycled, there is no need to
supplement high-pressure gas during use, which improves It is
convenient to use. In addition, the low-pressure cold-carrying
medium has a single cooling method, which only relies on
refrigeration components for cooling. Therefore, its cooling
process is easier to control then the cooling method that reset
with high-pressure gas throttling, thus effectively reducing the
difficulty of its operation. The chief surgeon does not need a
professional technician Accompany you to perform the entire
procedure.
[0056] 2. In the cryoablation device provided by the present
invention, the refrigeration assembly further includes a second
cold quantity exchange device having a hot fluid channel installed
on the medium supply pipeline and a cold fluid installed on the
medium recovery pipeline Channel, the cold fluid channel and the
hot fluid channel produce cold energy exchange, to pre-cool the
cold medium flowing through the hot fluid channel; the hot fluid
channel is connected between the medium storage tank and the The
first cold capacity exchange device. During cryoablation, the
medium supply pipeline, medium recovery pipeline, cryoablation
system catheter and cryo-balloon are used to circulate the
cold-carrying medium. During the flow, the cold generated by the
cold generating device passes through the first The cold quantity
exchange device is delivered to the medium supply and then
delivered to the human body through the catheter to cryoablate the
target tissue. The cold carrier medium that exchanges the
supercooled quantity with the target tissue then flows from the
catheter to the medium recovery At this time, the refrigerating
medium still has part of the remaining cold capacity, and then when
the refrigerating medium flows through the medium recovery
pipeline, due to the existence of the second cold capacity exchange
device, the remaining cold capacity in the refrigerating medium
will pass through the second cold capacity The exchange device is
conducted to the cooling medium in the medium supply pipeline, so
that the cooling medium there is pre-cooled. In the above process,
since the second cold quantity exchange device is upstream of the
first cold quantity exchange device on the medium supply pipeline
the temperature of the refrigerant-carrying medium in the medium
supply pipeline is higher than the temperature in the medium
recovery pipeline. Therefore, it can be ensured that the cold
energy is conducted from the medium recovery pipeline to the medium
supply pipeline. Through the above process, the remaining cold
capacity of the cooling medium in the medium recovery pipeline can
pre-cool the cooling medium, reducing the initial temperature of
the cooling medium when it enters the first cooling capacity
exchange device, and then at the same cooling capacity exchange
capacity Under the circumstance, this pre-cooled cold carrier
medium can reach a lower temperature, which makes the cryoablation
method that directly refrigerates the low-pressure medium more
likely to reach the temperature required for cryoablation, while
also increasing the temperature Utilization efficiency of cold
capacity.
[0057] 3. The cryoablation device provided by the present invention
further includes a bypass pipe which communicates with the medium
supply pipe and the medium recovery pipe and makes the medium
supply pipe and the medium recovery pipe form a series of media
storage The tank and the pre-cooling circuit of the first
refrigeration exchange device; and the bypass pipe and the medium
supply pipeline communicate with each other through a first
three-way valve. By using the bypass pipe the refrigerant can be
pre-cooled before entering the human body for freezing and
ablation. In the pre-cooling stage, the refrigerant will flow
through the medium supply pipeline and the first cooling capacity
after it comes out of the medium storage tank. Exchange device,
bypass pipe and medium recovery pipeline, and finally return to the
medium storage tank. The temperature of the cold-carrying medium
after pre-cooling is reduced, and it has a lower initial
temperature when entering the cryo-ablation stage, and after
cooling by the first cold quantity exchange device, it is easier to
reach the low temperature required for cryo-ablation. Therefore,
this action can further increase the possibility that the cooling
medium of the cryoablation device reaches the temperature required
for cryoablation.
[0058] 4. The freezing and ablation device provided by the present
invention further includes a cold storage device, which is
installed on the medium recovery pipeline and communicates with the
first cold quantity exchange device by a bypass pipe which is
suitable for storing the cold outflow from the first cold quantity
exchange device. the amount. In the pre-cooling stage, the cold
storage device can store part of the cold energy brought by the
cold-carrying medium. After the freezing and ablation stage starts,
the cold storage device can pre-cool the cold-carrying medium left
from the human body to make the second The temperature difference
between the cold fluid passage and the hot fluid passage at the
cold quantity exchange device increases, and the cold quantity
exchange rate at the second cold quantity exchange device is
increased, thereby further reducing the temperature of the cold
carrier medium in the medium supply pipeline. The pre-coded cooling
medium can reach a lower temperature after being finally cooled by
the first cooling capacity exchange device. Therefore, this action
can further ensure that the cryoablation device can reach the low
temperature required for cryoablation, and can further improve the
cold energy utilization efficiency and reduce cold energy
waste.
[0059] 5. The freezing and ablation device provided by the present
invention further includes a heat insulation device having a heat
insulation cavity suitable for reducing or isolating heat
conduction with the outside, and the first cold quantity exchange
device, the second cold heat The cold output ends of the quantity
exchange device, the cold storage device and the cold generation
device are located in the heat insulation cavity. The use of the
heat insulation device can avoid the low of cold energy during the
cold energy exchange process, and at the same time, the heat
preservation effect of the cold storage device is better, and the
cold storage device can avoid the cold energy loss during the cold
storage process.
[0060] 6. The freezing and ablation device provided by the present
invention the heat insulation device is a box, and a vacuuming
device connected to the heat insulation cavity it installed on the
heat insulation device. The heat-insulating cavity close to the
vacuum state can further reduce the rate of loss of cold energy, so
that the cryoablation device
[0061] 7. The cryoablation device provided by the present invention
further includes a rewarming circuit for holing the cold carrier
medium in the storage tank and then delivering it to the medium
input end of the catheter in the cryoablation device. In
cryoablation, the frozen target tissue needs to be rewarmed. The
ideal rewarming process can improve the surgical effect of
cryoablation and reduce the probability of postoperative
complications. The rewarming circuit provided in the present
invention can heat the cold-carrying medium and deliver it to the
target tissue through a catheter. This separately arranged
rewarming circuit can not only meet the needs of cryoablation for
rewarming, but also is very beneficial More precise control of the
temperature, process and time of rewarming can improve the cure
rate of surgery and reduce postoperative complications.
[0062] 8. In the cryoablation device provided by the present
invention, the rewarming circuit includes a rewarming tube, and a
heating device is connected in series with the rewarming tube; the
medium inlet end of the rewarming tube uses a second three-way
valve to eater the station The hot fluid passage is connected
upstream of the inlet port. After connecting, the reheating pipe to
the upstream of the second cold exchange device on the medium
supply pipeline, the reheating pipe is connected in parallel with
the first cold exchange device and the second cold exchange device.
At is time, the refrigerant used for heating The pipeline and the
pipeline used for cooling are independent. Therefore, it is
possible to avoid the residual cooling capacity of the first and
second cooling capacity exchanging devices from interfering with
the heating process of the carrier refrigerant dining the reheating
stage, reducing interference factors in the rehearing process, and
making the control of the reheating process more convenient
control.
[0063] 9. In the cryoablation device provided by the present
invention, the rewarming circuit further includes a rewarming
return has which is used to coot the medium output end of the
catheter in the cryoablation device with the medium storage tank.
The separate reheating return line can make the reheating process
forma separate reheating circuit composed of a medium storage tack,
a reheating tube, a cryoablation device, and a reheating return
line, which can further reduce the interference factors in the
reheating process, Make the process control of rewarming more
precise.
[0064] 10. The freezing and ablation device provided by the present
invention further includes a heat insulation device, the heat
insulation device having a hot insulation cavity suitable for
reducing or isolating hot conduction with the outside, the first
cold quantity exchange device, the second cold heat The cold output
ends of the quantity exchange device, the cold storage device and
the cold generation device are located in the heat insulation
cavity; the reheating return pipe is outside the heat insulation
device. After the reheating return pipe is arranged outside the
heat insulation device, it can prevent the reheating return pipe
from taking away the cold energy in the cold storage device or the
second cold energy exchange device when transporting the reheated
cold carrier medium, thereby increasing the cold energy Utilization
rate.
[0065] 11. The technical solution provided by the present invention
also includes a cryo-ablation method, which includes the following
steps: pre-cooling, posing a low-pressure cold-carrying medium cold
cycle into the cold generation device for cooling; ablate,
completing the pre-cooling The cold-carrying medium is circulated
into the cold generation device, and then passed into the target
tissue of the human body, so that the cold-carrying medium and the
target tissue can exchange cold, so that the target tissue is
cooled and the target tissue is cryoablated; Recover, transport the
cold-carrying medium after the cold exchange with the target tissue
from the human body, and transport it to the storage tank;
rewarming, re-warming, stop passing the cooled cold-carrying medium
into the human body to make the target To warm up the organization.
In the above steps, due to the pre-cooling step, the cooling medium
has a lower temperature after being pre-cooled, in that the initial
temperature dining the cooling process in the ablation stage will
be lower, so the temperature that can be finally reached will be
lower. Compared with the prior art method of directly cooling the
cold-carrying medium and then passing it into the human body, the
cold-carrying medium in is method can more easily reach the low
temperature required for cryoablation.
[0066] 12. In the cryoablation method provided by the present
invention, in the recovery step, the cold-carrying medium after the
cold exchange with the target tissue is transported out of the
human body, and the remaining cold in the cold-carrying medium and
the non-passing cold are used. The cooling medium in the cooling
capacity generating device exchanges the cooling capacity, so that
the cooling medium that gas not been posed into the cooling
capacity generating device is cooled and then transported to the
cooling capacity generating device. In the above steps, the
remaining cold energy of the refrigerant-carrying medium in the
medium recovery pipeline can be reused, the utilization efficiency
of the cold energy can be improved, and the power burden of the
cold energy generating device can be reduced.
[0067] 13. In the freezing and ablation method provided by the
present invention, a part of the cold energy is stored in the
pre-cooling stage, and the cold energy is transported to the
cold-carrying medium sent from the human body to cool the
cold-carrying medium sent from the human body. Through the above
steps, the pre-stored cooling capacity can be transferred to the
medium recovery pipeline to reduce the temperature of the cooling
medium, so that the residual cooling capacity of the transported
cooling medium can be used in the recovery step to cool down the
unimported cooling medium The temperature difference in the process
is larger, and the cooling capacity exchange speed between the two
is increased, so that the temperature of the cooling medium that is
not input into the human body is lower, and it is easier to reach
the temperature required for freezing and ablation under the
cooling of the cooling capacity device.
[0068] In summary, the cryoablation device and cryoablation method
provided by the present invention have low risk factors, simple
operation, convenient use, and at the same time have the advantages
of high cold utilization efficiency, actuate temperature control
and the like.
DESCRIPTION OF THE DRAWINGS
[0069] In order to explain the specific embodiments of the present
invention or the technical solutions in the prior art more clearly,
the following will briefly introduce the drawings that need to be
used in the specific embodiments or the description of the prior
art. Obviously, the appendix in the following description The
drawings are some embodiments of the present invention. For those
of ordinary skill in the art, other drawings can be obtained based
on these drawings without creative work.
[0070] FIG. 1 is a schematic diagram of the mechanism of the
cryoablation device provided in Embodiment 1 of the present
invention;
[0071] FIG. 2 is a schematic diagram of the flow of the cold
carrier medium in the pre-cooling stage of the cryoablation device
shown in FIG. 1;
[0072] FIG. 3 is a schematic diagram of the flow of the cold medium
in the cryoablation device shown in FIG. 1 in the cryoablation
stage;
[0073] FIG. 4 is a schematic diagram of the flow of the cold medium
in the cryoablation device shown in FIG. 1 during the rewarming
stage;
[0074] FIG. 5 is a flowchart of the cryoablation method provided in
Embodiment 3 of the present invention;
DESCRIPTION OF REFERENCE SIGNS
[0075] 1--medium storage tank, 2--medium supply pipeline, 3--medium
recovery pipeline, 4--cold generating device, 5--first cold-energy
exchange device, 6--second cold-energy exchange device, 7--pipe,
8--Freezing balloon, 9--bypass pipe, 10--first three-way valve,
11--cold storage device, 12--heat insulation device, 13--hot
insulation chamber, 14--vacuum device, 15--reheating tube,
16--Heating device, 17--second three-way valve, 18--reheating
return pipe, 19--third three-way valve, 20--pumping device,
21--flow meter, 22--thermometer, 23--check valve, 24--hot
dissipation Device.
DETAILED WAYS
[0076] The technical solutions of the present invention will be
clearly and completely described below in conjunction with the
accompanying drawings. Obviously, the described embodiments are
part of the embodiments of the present invention, rather than all
of them. Based on the embodiments of the present invention, all
other embodiments obtained by those of ordinary skill in the art
without creative work shall fall within the protection scope of the
present invention.
[0077] In the description of the present invention, it should be
noted that the terms "center", "upper", "lower", "left", "right",
"vertical", "horizontal", "inner", "outer", etc. The indicated
orientation or positional relationship is based on the orientation
or positional relationship shown in the drawings, which is only for
the convenience of describing the present purposes, and cannot be
understood as indicating or implying relative importance.
[0078] In the description of the present invention, it should be
noted that the term "installed", "connected" and "connected" should
be understood in a broad sense, unless otherwise clearly specified
and limited. For example, they can be fixed or detachable.
Connected or integrally connected; it can be a mechanical
connection or an electrical connection; it can be directly
connected or indirectly connected through an intermediate medium,
and it can be the internal communication between two components.
For those of ordinary skill in the art, the specific meaning of the
above-mentioned terms in the present invention can be understood in
specific situations.
[0079] In addition, the technical features involved in the
different embodiments of the present invention described below can
be combined with each other as long as they the not conflict with
each other.
Example 1
[0080] As shown in FIGS. 1 to 4, it is the first embodiment of the
present invention. This embodiment provides a cryoablation device,
which includes a cryo-balloon 8, a catheter 7, a medium storage
tank 1, a medium supply line 2, and a medium recovery The pipeline
3 and the refrigeration components; the refrigerating balloon 8
circulates with a cold medium, which is suitable for contacting
human tissue and performing cryoablation; the catheter 7 is
connected to the refrigerating balloon 8 and has a medium input end
and a medium output end, It is suitable for inputting and
outputting cold-carrying medium into the freezing balloon 8; the
cold-carrying medium is stored in the medium stooge tank 1, and the
cold-carrying medium is a low-pressure medium; one end of the
medium supply pipeline 2 is connected with the medium storage tank
1, and the other end The inlet end of the pipe 7 is connected; one
end of the medium recovery pipe 3 is connected with the medium
storage tank 1, and the other end is connected with the outlet end
of the pipe 7; the refrigeration component is connected in series
with the medium supply pipe 2 and is suitable for supplying the
medium inside the pipe 2 The cooling medium is used for cooling and
heat exchange.
[0081] In the process of cryoablation, the cooling medium flows
according to the following path: after flowing out of the medium
storage tank 1 along the medium supply pipeline 2, passing through
the refrigeration components, the temperature of the cooling medium
drops, and then enters the medium in the conduit 7 The input end
then flows into the freezing balloon 8 through the balloon to
contact the target tissue, and then flows out from the media output
end of the catheter 7 to the media recovery pipeline 3, and finally
returns to the media storage tank 1 to complete a cycle. In the
above process, since the original high-pressure gas is replaced
with the cold-carrying medium, the cold-carrying medium is directly
refrigerated. Compared with the high-pressure gas, it is less prone
to explosion, which can effectively reduce the risk of the
cryoablation device during use At the same time, because the
low-pressure cooling medium can be recycled, there is no need to
supplement high-pressure gas during use, which improves its
convenience in use. In addition, the low-pressure cold-carrying
medium has a single cooling method, which only relies on
refrigeration components for cooling. Therefore, the cooling
process is easier to control than the cooling method that relies on
high-pressure gas throttling, thus effectively reducing the
difficulty of its operation. The chief surgeon does not need a
professional technician Accompany you to perform the entire
procedure.
[0082] As a specific implementation of the refrigeration assembly,
the refrigeration assembly includes a refrigeration generating
device 4, a first refrigeration exchange device 5, and a second
refrigeration exchange device 6. The cooling capacity generating
device 4 is used to provide cooling rapacity; the first cooling
capacity exchanging device 5 is installed on the medium supply
pipeline 2, and the cooling capacity generating device 4 provides
cooling capacity to the first cooling capacity exchanging device 5.
The first refrigeration exchange device 5 is used to perform
refrigeration and heat exchange on the cooling medium passing
through the first refrigeration exchange device 5; the second
refrigeration exchange device 6 has heat installed on the medium
supply pipe 2 The fluid channel and the cold fluid channel
installed on the medium recovery pipeline 3, the cold fluid channel
and the hot fluid channel generate cold energy exchange, and the
cold medium flowing through the hot fluid channel Cold; the hot
fluid channel is connected between the medium storage tank 1 and
the first cold exchange device 5.
[0083] When the above-mentioned refrigeration component
participates in cryoablation, the medium supply line 2, the medium
recovery line 3, the catheter 7 of the cryoablation system, and the
cryo-balloon 8 are used to make the cold-carrying medium circulate.
The cold energy generated at 4 places is delivered to the medium
supply pipeline 2 through the first cold energy exchange device 5,
and then delivered to the human body through the catheter 7 for
cryoablation of the target tissue, and the carrier for supercooling
exchange with the target tissue. The cold medium then flows from
the conduit 7 to the medium recovery pipeline 3. At this time, the
cold carrier medium still has some cold capacity. Then, when the
cold carrier flows through the medium recovery line 3, due to the
second cold exchange device 6 With the existence of, the remaining
cold in the cold-carrying medium will be transferred to the
cold-carrying medium in the medium supply pipeline 2 through the
second cold-exchanging device 6, so that the cold-carrying medium
there is pre-cooled.
[0084] In the above process, since the second cooling capacity
exchange device 6 is upstream of the first cooling capacity
exchange device 5 on the medium supply pipe 2, the temperature of
the cooling medium in the medium supply pipe is higher than that of
the medium recovery. The temperature in the pipeline 3 can thus
ensure that the cold energy is conducted from the medium recovery
pipeline 3 to the medium supply pipeline 2. Through the above
process, the remaining cold capacity of the cooling medium in the
medium recovery pipeline 3 can pre-cool the cooling medium, reduce
the initial temperature of the cooling medium when it enters the
first cooling capacity exchange device 5, and then at the same
cooling capacity In the case of exchange volume, this pre-cooled
cold carrier medium can reach a lower temperature, so that this
cryoablation method that directly cools the low-pressure medium is
more likely to reach the temperature required for cryoablation, and
at the same time Improve the efficiency of cold utilization.
[0085] Specifically, the cold generation device 4 in this
embodiment is specifically a miniature ultra-low temperature
refrigerator capable of providing a cold source below -120.degree.
C., which can be in the form of pulse tube, Stirling, mixed working
fluid throttling, thermoacoustic, etc. It can be one or more units.
When multiple units work together, the joint mode can be series or
parallel. The cooling medium in this embodiment is a medium with a
low freezing point, such as absolute ethanol.
[0086] In order to further reduce the minimum temperature that the
cooling medium can reach, it also includes a bypass pipe 9, which
communicates with the medium supply pipe 2 and the medium recovery
pipe 3, and allows the medium supply pipe 2 and The medium recovery
pipeline 3 forms a pre-cooling circuit connecting the medium
storage tank 1 and the first cooling capacity exchange device 5 in
series; and the bypass pipe 9 and the medium supply pipeline 2 are
in communication through the first three-way valve 10.
[0087] By using the by-pass pipe 9, the refrigerant can be
pro-cooled before entering the human body for freezing and
ablation. In the pre-cooling stage, the refrigerant will flow
through the medium supply pipeline 2 and the second after coming
out of the medium storage tank 1. A cold capacity exchange device
5, a bypass pipe 9 and a medium recovery pipeline 3, and finally
return to the medium storage tank 1. The temperature of the cold
carrier medium after pre-cooling is reduced, and has a lower
initial temperature when entering the cryoablation stage, and after
cooling by the first cold quantity exchange device 5, it is easier
to reach the low temperature required for cryo-ablation. Therefore,
this action can further increase the possibility that the
cryoablation device is carrying the cold medium to reach the
temperature required for cryoablation.
[0088] As an improved embodiment of the cryo-ablation device, it
also includes a cold storage device 11, which is installed on the
medium recovery pipeline 3, and communicates with the first cold
energy exchange device 5 by a bypass pipe 9, suitable for storing
the first cold energy exchange T, amount of cold flowing out of the
device 5. In this embodiment, the cold storage device 11 is
specifically a box filled with a cold storage medium with a higher
specific heat opacity. The medium recovery pipeline 3 passes
through the cold storage device 22, and the side wall of the
pipeline and the cold storage medium in the cold storage device 11
are used to generate cold energy exchange.
[0089] In the pre-cooling stage, the cold storage device 11 can
store part of the cold energy brought by the cold-carrying medium.
After the freezing and ablation stage starts, the cold storage
device 11 on pre-cool the cold-carrying medium left from the human
body to make the first The temperature difference between the cold
fluid passage and the hot fluid passage of the second cold quantity
exchange device 6 is increased, which increases the cold quantity
exchange rate at the second cold quantity exchange device 6,
thereby further increasing the temperature of the cold medium in
the medium supply pipeline 2 Lowering, these pre-cooled cooling
medium on reach a lower temperature after the first cooling
capacity exchange device 5 undergoes float cooling. Therefore, this
action can further ensure that the cryoablation device can reach
the low temperature required for cryoablation, and can further
improve the cold energy utilization efficiency and reduce cold
energy waste.
[0090] In order to reduce the loss of cold energy, it also includes
a heat insulation device 12, the heat insulation device 12 has a
heat insulation cavity 13 suitable for redoing or exchange process,
and at the same time, the heat preservation effect of the cold
storage device 11 is better, and the cold storage device 11 can
avoid cold energy loss during the cold storage process.
[0091] Specifically, the heat insulation device 12 is a box, and a
vacuum device 14 communicating with the heat insulation cavity 13
is installed on the heat insulation device 12. The heat-insulating
cavity 13 close to the vacuum state can further reduce the loss
rate of cold energy, so that the cryoablation device further
improves the utilization efficiency of cold energy. The vacuum pump
14 is specifically a small vacuum pump.
[0092] As another alternative implementation of the heat insulation
device, the heat insulation device 12 is a box, and the heat
insulation cavity 13 is filled with a heat insulation material,
where the heat insulation material may be a polyurethane foam
material or aerogel material.
[0093] In order to meet the needs of the target tissue during
cryoablation for rewarming after freezing, this embodiment also
includes a rewarming circuit for heating the cold carrier medium in
the storage tank and then transporting it to freezing The media
input end of the catheter 7 in the ablation device. In
cryoablation, the frozen target tissue needs to be rewarmed. The
ideal rewarming process can improve the surgical effect of
cryoablation and reduce the probability of postoperative
complications. The rewarming circuit provided in the present
invention can heat the cold-carrying medium and transport it to the
target tissue through the catheter 7. This separately arranged
rewarming circuit can not only meet the needs of cryoablation for
rewarming, but also is very useful It is conducive to more precise
control of the temperature, process and time of rewarming, thereby
increasing the surgical cure rate and reducing postoperative
complications.
[0094] Specifically, the reheating circuit includes a reheating
pipe 15 which is connected in series with a heating device 16; the
medium inlet end of the reheating pipe 15 uses a second three-way
valve 17 and enters the hot fluid The inlet of the channel is
connected upstream. After the reheating pipe 15 is connected to the
upstream of the second refrigeration exchange device 6 on the
medium supply pipeline 2, the reheating pipe 15 is connected in
parallel with the first refrigeration exchange device 5 and the
second refrigeration exchange device 6. The pipeline used for
heating the refrigerant and the pipeline used for cooling are
independent of each other. Therefore, it is possible to avoid the
residual cooling capacity of the first refrigeration exchange
device 5 and the second refrigeration exchange device 6 from
interfering with the heating process of the easier refrigerant
during the rewarming stage, reduce the interference factors of the
rewarming process, and control the rewarming process It is easier
to control.
[0095] As an alternative implementation of the above reheating
circuit, the reheating circuit includes: a reheating pipe 15; the
medium inlet end of the reheating pipe 15 is installed on the
medium supply pipeline 2 by using a second three-way valve 17 The
side that does not enter the first cold quantity exchange device 5
is connected. In this alternative embodiment, there is no series
heating device on the rewarming circuit, but only the uncooled cold
easier medium is introduced into the catheter to participate in the
rewarming process, and the body's own heat is used for rewarming.
This makes the temperature rise of the targeted tissues more gentle
and reduces the damage to healthy tissues caused by
cryoablation.
[0096] As a further improvement of the reheating circuit, the
reheating circuit also includes a reheating return line, which is
used to connect the medium output end of the catheter 7 in the
cryoablation device with the recovery port of the medium storage
tank 1 Connected. The separate reheating return line can make the
reheating process form a separate reheating circuit composed of the
medium storage tank 1, the reheating tube 15, the cryoablation
device, and the reheating return line, thereby further reducing the
temperature during the reheating process. Interference factors make
the process of rewarming more precise.
[0097] Specifically, the reheating return pipe includes a reheating
return pipe 18, both ends of which are connected with the medium
recovery pipe 3 and connected in parallel with the second cold
quantity exchange device 6; the medium inlet end of the reheating
return pipe 18 is used The third three-way valve 19 is connected to
the medium supply pipeline 2. Further, the reheating return pipe 18
is located outside the heat insulation device 12. After the
reheating return pipe 18 is arranged outside the heat insulation
device 12, it can prevent the reheating return pipe 18 from taking
away the cold storage device 11 or the second cold energy exchange
device 6 when the reheating refrigeration medium is transported.
Increase the utilization rate of cooling capacity.
[0098] In order to ensure the smooth circulation of the cooling
medium, a pumping device 20 is connected in series to the medium
supply pipeline 2 or the medium recovery pipeline 3, and the
pumping device 20 is adapted to provide power for the flow of the
cooling medium.
[0099] The cryoablation device provided in this embodiment also
includes an operating device. The operating device includes a
handle and an actuator for operating the catheter 7 to reach the
target tissue for ablation. When performing cryoablation, the
catheter 7 is a pipe that transports low-temperature cold-carrying
medium, and is made of a material with a certain degree of
toughness, a small thermal conductivity, and physiological
compatibility. It has multiple flow channels inside, which are
respectively The inlet and outlet flow channels, functional
channels and isolation chambers of cold media. The cooling medium
inlet and outlet flow channels are distributed on both sides to
insulate the inlet and outlet fluids and avoid thermal short
circuits. The functional channel is located in the center of the
catheter 7 and is used for routing of functional components such as
sensors and guidewires. The isolation cavities are distributed at
both ends of the cold medium flow channel to further reduce the
heat exchange of the fluid in and out. The tube 7 is wrapped with
thermal insulation material to reduce the heat transfer between the
cold-carrying medium in the duct 7 and external human tissues, on
the one hand, to reduce the heat leakage of the cold-carrying
medium, and on the other hand, to avoid freezing of the tissue
caused by the low temperature of the outer wall of the duct 7 The
cryo-balloon 8 is used for cryoablation of the target tissue, and
has a medium inlet and a medium outlet inside. The medium inlets
connected with the inlet of the catheter 7 and the outlet of the
medium is connected with the outlet of the catheter 7. After the
balloon contacts the tissue, the cold-carrying medium exchanges
heat with the tissue through the balloon wall.
Example 2
[0100] As shown in FIG. 5, it is the second embodiment of the
present invention. This embodiment provides a cryoablation method.
In this method, a cold-carrying medium using a low-pressure medium
is directly passed into the human body after refrigeration to
perform targeted tissues on the human body. Cryoablation includes
the following steps:
[0101] For pre-cooling, a low-pressure cooling medium is passed
into the cooling capacity generating device 4 for cooling.
[0102] In ablation, the pre-cooled cold-carrying medium is
circulated into the cold generation device 4, and then passed into
the target tissue of the human body, so that the cold-carrying
medium and the target tissue can exchange cold, so that the target
tissue is cooled Then the target tissue is cryoablated.
[0103] Recycling, transport the cold-carrying medium after cold
exchange with the target taste from the human body and transport it
to the storage tank.
[0104] After rewarming, stop passing the cooled cold carrier medium
into the human body to raise the temperature of the target
tissue.
[0105] In the above steps, due to the pre-cooling slip, the cooling
medium has a lower temperature after being pre-cooled, so that the
initial temperature during the cooling process in the ablation
stage will be lower, so the temperature that can be finally reached
will be lower. Compared with the prior art method of directly
cooling the cold-carrying medium and then passing it into the human
body, the cold-carrying medium in this method can more easily reach
the low temperature required for cryoablation.
[0106] In the recovery step, the cold-carrying medium after the
cold exchange with the target tissue is transported from the human
body, and the remaining cold in the cold-carrying medium and the
cold-carrying medium that has not been passed into the cold
generating device 4 are used for cooling. The quantity exchange,
the cooling medium that has not yet passed into the cooling
capacity generating device 4 is cooled and then transported to the
cooling capacity generating device 4. In the recovery step, the
remaining cold energy of the cooling medium in the medium recovery
pipeline 3 can be reused, the utilization efficiency of the cold
energy can be improved, and the power burden of the cold energy
generating device 4 can be reduced.
[0107] In the pre-cooling step, a part of the cold energy is
stored, and the cold energy is transported to the cold-carrying
medium sent from the human body to cool the cold-carrying medium
sent from the human body. Through the above steps, these pre-stored
refrigeration can be transferred to the medium recovery pipeline 3
to reduce the temperature of the refrigerating medium, so that the
residual refrigeration of the conveyed refrigerating medium can be
used in the recovery step to perform The temperature difference in
the
[0108] As a specific embodiment of the rewarming step, in the
rewarming step, the cooling medium is circulated through the
heating device (16), the cooling medium is heated, and then the
heated cooling medium is passed into the target of the human body
At the tissue, the cold-carrying medium and the target tissue
generate heat exchange, so that the temperature of the target
tissue after cooling is raised.
[0109] As an alternative implementation of the above-mentioned
rewarming step, in the rewarming step, a cold-carrying medium that
has not been refrigerated can also be input into the human body, so
that the target tissue can exchange heat with the cold-carrying
medium that has not beet refrigerated and then increase in
temperature.
[0110] In combination with the cryoablation device in Embodiment 1,
the specific process of the cryoablation method in this embodiment
is:
[0111] In the pre-cooling stage, see FIG. 2. The cooling capacity
generating device 4 and the pumping device 20 are opened, and the
three three-way valves are adjusted to make the cooling medium flow
according to the following process: After the normal temperature
cooling medium flows out of the medium storage tank 1, After
passing through the flow meter, the pumping device 20, and the flow
regulating valve, it enters the heat insulation device 12. After
passing through the second refrigeration exchange device 6 to
exchange heat with the refluxing refrigerating medium for
pre-cooling, it enters the first refrigeration exchange device 5
for cooling, After passing through the bypass pipe 9, it enters the
cold storage device 11, stores a part of the cold energy in the
cold storage device 11, and then flows back to the second cold
energy exchange device 6 to pre-cool the cold carrier medium left
from the medium storage tank 1, and finally It flows out of the
heat insulation device 12 and finally returns to the medium storage
tank 1.
[0112] After about 20 minutes of pre-cooling cycle, the cooling
medium drops to minus 80-100.degree. C.
[0113] In the ablation stage, refer to FIG. 3. After the
pre-cooling is completed, adjust the three three-way valves so that
the cooling medium flows according to the following process: after
passing through the flow meter, the pumping device 20, and the flow
regulating valve, it enters the insulation device 12, and passes
through the first After the second cooling capacity exchange device
6 exchanges heat with the refluxed cooling medium, it enters the
first cooling capacity exchange device 5 for cooling. After the
cooling medium is cooled by the first cooling capacity exchange
device 5, it flows out of the heat insulation device 12 and enters
the duct 7. Then enter the freezing balloon 8 for ablation, then
flow out of the catheter 7, return to the heat insulation device
12, and flow through the cold storage device 11. At this time, the
temperature of the cold carrier medium is higher than the
temperature of the heat storage medium in the cold storage device
11. The heat storage medium releases heat and the temperature
drops, and then enters the second cooling capacity exchange device
6 to exchange cooling capacity for the cooling medium flowing out
of the medium storage tank 1, then exits the heat insulation device
12 and returns to the medium storage tank 1.
[0114] In the rewarming stage, refer to FIG. 4. After the freezing
and ablation is completed, adjust the three three-way valves to
make the cooling medium flow according to the following process:
the cooling medium first comes out of the medium storage tank 1 and
flows through the flow meter and the pumping device 20 After the
flow control valve, it enters the heating device 16 and is heated
to 37.degree. C. by the heating device 16, and then enters the
catheter 7 through the rewarming tube 15, heating and rewarming the
ablated tissue, and flows out of the catheter 7 and passes through
the third three-way The valve 10 flows through the reheating return
pipe 18 and then returns to the medium storage tank 1.
[0115] Obviously, the above-mentioned embodiments are merely
examples for clear description, and are not intended to limit the
implementation. For those of ordinary skill in the art, other
changes or changes in different forms can be made on the basis of
the above description. It is unnecessary and impossible to list all
the implementation methods here. The obvious changes or
modifications derived from this are still within the protection
scope created by the present invention.
* * * * *