Radiation Biodosimetry Systems

Abstract

Disclosed herein are compositions and methods for accurately estimating the absorbed dose of radiation indicated by a subject based on the expression pattern of a panel of radiation-modulated (RM) genes at various time points following exposure of the subject to ionizing radiation.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional of U.S. patent application Ser. No. 16/532,138, filed Aug. 9, 2019, which is a divisional of U.S. patent application Ser. No. 14/823,433, filed on Aug. 11, 2015 and now issued as U.S. Pat. No. 10,435,747, and claims the benefit of U.S. Provisional Application No. 62/038,969, filed Aug. 19, 2014, the disclosures of which are hereby incorporated by reference in their entirety for all purposes.

REFERENCE TO A SEQUENCE LISTING SUBMITTED VIA EFS-WEB

[0003] The content of the ASCII text file of the sequence listing named "112624_00614_ST25.txt" which is 108 kb in size was created on Nov. 10, 2015 and electronically submitted via EFS-Web herewith the application is incorporated herein by reference in its entirety.

BACKGROUND

[0004] Radiation exposure is one of the most serious hazards of the modern era. The health consequences to individuals and populations exposed to radiological incidents, accidental or otherwise, can range from negligible to fatal depending on the amount of radiation that is absorbed by an individual. Yet, it is often difficult or impossible to quickly determine the absorbed dose of radiation for an individual or population after a radiological event and thereby determine an appropriate course of treatment. This is particularly critical when large numbers of individuals are potentially affected by radiation exposure and must be quickly "triaged" to prioritize treatment strategies. Thus, there is a great need for systems that quickly estimate, post-hoc, the absorbed dose of radiation by an individual resulting from an ionizing radiation exposure incident.

BRIEF SUMMARY OF THE INVENTION

[0005] Disclosed herein are compositions and methods for accurately estimating the absorbed dose of radiation suffered by a subject based on the expression pattern in RNA obtained from peripheral blood of a panel of radiation-modulated (RM) genes at various time points following exposure of the subject to ionizing radiation.

[0006] Accordingly in one aspect provided herein is a radiation biodosimetry assay system, comprising a plurality of nucleic acid amplification reactions comprising (i) mRNA or cDNA from a human subject suspected of (but not necessarily) suffering from radiation exposure; (ii) primer pairs capable of hybridizing under stringent conditions to mRNAs or cDNAs comprising the nucleotide sequences referred to in Table 4 or the complementary sequences thereof, wherein each primer pair hybridizes to a different one of the mRNAs or cDNAs; and (iii) a thermostable enzyme suitable for amplification of target amplicon sequences from the mRNAs or cDNAs. A mathematical algorithm that converts gene expression results to estimated absorbed dose of radiation.

[0007] In some embodiments the one or more nucleic acid amplification reactions further comprise detectably labeled TAQMAN.RTM. probes capable of hybridizing under stringent conditions to the mRNAs or cDNAs. In some embodiments the thermostable enzyme is a thermostable polymerase.

[0008] In some embodiments the mRNA is from a subject that was exposed to radiation about 4-hours to about seven days prior to the time at which a biological sample comprising the mRNA was obtained.

[0009] In another aspect provided herein is a radiation biomarker assay kit, comprising a nucleic acid probe set consisting essentially of nucleic acid probes that hybridize specifically with nucleic acid targets comprising at least one of the nucleotide sequences referred to in SEQ ID NOs: 1-39 or the complementary sequences thereof. In some embodiments the probe set comprises no more than 100 probes. In some embodiments the probe set consists of the nucleic acid probes that hybridize specifically with the nucleic acid targets.

[0010] In some embodiments the nucleic acid probe set comprises primer pairs and TAQMAN probes suitable for qPCR analysis of mRNAs or cDNAs comprising at least one of the nucleotide sequences referred to in SEQ ID NOS: 1-39 or the complementary sequences thereof. In some embodiments the nucleic acid probes are provided in a multi-well plate. In some embodiments, where the nucleic acid probes are provided in a multi-well plate, at least two nucleic acid probes that hybridize to at least two different nucleic acid targets are in the same wells of the multi-well plate.

[0011] In some embodiments the kit also includes radiation exposure positive and negative control mRNA samples or cDNAs thereof. In another aspect provided herein is a method for assessing a dose of ionizing radiation absorbed by a subject, comprising (i) determining the mRNA expression levels of mRNAs comprising at least one of the nucleotide sequences referred to in SEQ ID NOs: 1-39 in a biological sample, comprising mRNA from the subject, to obtain an expression profile; and (ii) transforming the gene expression profile and when available, the duration of time from exposure to sample collection, into a measure of absorbed dose of radiation for the subject based on a mathematical algorithm. In one embodiment, the algorithm utilizes multiple random forest regression trees to estimate absorbed dose and confidence limits and then a top-level logic layer to combine outputs into a single estimated absorbed dose with confidence limits.

[0012] In some embodiments the method further includes treating the subject based on the estimated absorbed dose of radiation determined in step (ii).

[0013] In some embodiments the absorbed dose of ionizing radiation is determined within about seven days of subject exposure to ionizing radiation.

[0014] In some embodiments the method also includes a step of obtaining the biological sample from the subject prior to step (i).

[0015] In a further aspect provided herein is a method for radiation treatment triage of a subject in need thereof comprising (i) determining the mRNA expression levels of mRNAs comprising the nucleotide sequences referred to in at least one of SEQ ID NOs: 1-39 (or any other sequence identifier included herein, in any combination) in a biological sample comprising leukocyte mRNA from the subject to obtain a gene expression profile; and (ii) providing a suitable treatment for radiation exposure to the subject based on the expression levels of the genes.

INCORPORATION BY REFERENCE

[0016] All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, and patent application was specifically and individually indicated to be incorporated by reference.

BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The present invention will be better understood and features, aspects and advantages other than those set forth above will become apparent when consideration is given to the following detailed description thereof. Such detailed description makes reference to the following drawings, wherein:

[0018] FIG. 1A show tables listing a set of 28 radiation modulated (RM) genes and their expression pattern at various time points following absorption of ionizing radiation.

[0019] FIG. 1B show tables listing a set of 28 radiation modulated (RM) genes and their expression pattern at various time points following absorption of ionizing radiation.

[0020] FIG. 2 shows a time series (days 1-7) of plots of actual delivered ionizing radiation dosage values (0 Gy to 10 Gy) versus estimated absorbed dose of radiation based on changes in RM gene expression in peripheral blood

[0021] FIG. 3 shows a table providing the percentage accuracy (within 1 Gy) of the biodosimetry algorithm's absorbed radiation dose estimate based on expression of 29 RM genes in peripheral blood collected from rhesus macaque non-human primate (NHPs) at various time points (1-7 days) following exposure to irradiation doses ranging from 0 Gy to 10 Gy.

[0022] FIG. 4 shows a table providing the percentage accuracy (within 0.5 Gy) of the biodosimetry algorithm's absorbed radiation dose estimate based on expression of 29 RM genes in peripheral blood from NHPs at various time points (1-7 days) following exposure to irradiation doses ranging from 0 Gy to 10 Gy.

[0023] FIG. 5 shows scatter plots of changes in RM gene expression in male vs. female NHPs following radiation exposure of various doses and at different time points following radiation exposure. As shown, male and female RM gene expression responses were very closely correlated for the 29 RM genes.

[0024] FIG. 6 shows a table describing the sensitivity and specificity of the biodosimetry algorithm in various NHP and human irradiation models.

[0025] FIG. 7 shows an overview of an exemplary, non-limiting, embodiment of biodosimetry workflow illustrating the steps of: blood sample collection, RNA isolation, reverse transcription to obtain cDNA, pre-amplification of the cDNA, and qPCR assay of a RM biomarker and reference gene panel.

[0026] FIG. 8 shows a single regression tree in a random forest example. This tree generates an estimated absorbed dose using the relative expression levels of gene biomarkers, HBA2 and IL27RA, and the absolute expression level of gene biomarker, COCH.

[0027] FIG. 9 shows a schematic overview on human and NHP data sets, cross-species conversion approaches to utilize the NHP single-dose (SD) biodosimetry algorithm to predict absorbed dose in human in case of acute radiation exposure. Cross-species conversion algorithms were developed with human and NHP fractionated-dose (FD) models that showed a good cross-model compatibility with NHP SD models.

[0028] FIG. 10A shows a schematic overview on the approach to convert NHP fractionated dose (FD) data to the corresponding values in NHP single-dose (SD) data by 3-dimensional linear scaling of day, dose, and expression values.

[0029] FIG. 10B shows the optimal range (in blue) of dose/day scaling factors for 12 Gy/day-6 data points of individual biomarkers (top panels) and a unified scaling factor (bottom panel) for 29 tested biomarkers.

[0030] FIG. 11A shows dose prediction performances of a random forests model based on 7 correlated biomarker genes on NHP SD data (for day 3, as an example).

[0031] FIG. 11B shows dose prediction performances of a random forests model based on 7 correlated biomarker genes on converted NHP FD values across all days by matching day/cumulative dose, 3D scaling, and 3D scaling followed by multi-gene regression. Prediction accuracies within 1.0 Gy are shown.

[0032] FIG. 12A shows correlation of individual biomarker expression values between NHP fractionated dose (FD) and human TBI, magnitude of expressional changes across dose, and mean absolute difference (MAD) between NHP FD and human TBI data points.

[0033] FIG. 12B shows dose response curves of the top 4 inter-species correlated genes in NHP FD and human TBI data.

[0034] FIG. 13A shows dose prediction performances of a random forests model based on 10 inter-species biomarker genes on NHP FD data.

[0035] FIG. 13B shows dose prediction performances of a random forests model based on 10 inter-species biomarker genes on unconverted and converted human TBI values by value shift, and value shift followed by multi-gene regression. Prediction accuracies within 1.0 Gy are shown.

DETAILED DESCRIPTION

[0036] In General. Before the present materials and methods are described, it is understood that this invention is not limited to the particular methodology, protocols, materials, and reagents described, as these may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention which will be limited only by the appended claims.

[0037] It must be noted that as used herein and in the appended claims, the singular forms "a", "an", and "the" include plural reference unless the context clearly dictates otherwise. As well, the terms "a" (or "an"), "one or more" and "at least one" can be used interchangeably herein. It is also to be noted that the terms "comprising", "including", and "having" can be used interchangeably.

[0038] Unless defined otherwise, all technical and scientific terms used herein have the same meanings as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are now described. All publications and patents specifically mentioned herein are incorporated by reference for all purposes including describing and disclosing the chemicals, cell lines, vectors, animals, instruments, statistical analysis and methodologies which are reported in the publications which might be used in connection with the invention. All references cited in this specification are to be taken as indicative of the level of skill in the art. Nothing herein is to be construed as an admission that the invention is not entitled to antedate such disclosure by virtue of prior invention.

[0039] The Invention. The present invention provides methods for estimating absorbed dose of ionizing radiation by a subject, which includes the steps of: (i) determining the mRNA expression levels of mRNAs comprising the nucleotide sequences referred to in SEQ ID NOs: 1-39 in a biological sample comprising peripheral blood mRNA collected from the subject to obtain an expression profile; and (ii) transforming the gene expression profile and when available, the duration of time from exposure to sample collection into an estimated absorbed dose of ionizing radiation and confidence limits for a subject based on a mathematical algorithm. For each of several durations for which training data were available, one primary random forest was developed to estimate absorbed dose of radiation. Additional secondary random forests were developed to provide more accurate dosimetry in narrow dosage intervals. The top-level logic layer uses the primary random forest to generate an initial estimate of absorbed dose of radiation, and based on that value, may select additional random forests to construct more refined estimates of absorbed dose, with confidence limits.

[0040] In some embodiments the method also includes treating the subject based on the absorbed dose of ionizing radiation determined in step (ii) above. In some embodiments the absorbed dose of ionizing radiation is determined within about seven days of exposure to the ionizing radiation, e.g., within about 30 minutes, 1 hour, 3 hours, 6 hours, 8 hours, 24 hours, 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, or another time period within seven days following ionizing irradiation. In some embodiments, the absorbed dose of ionizing radiation is within the range of about 0.5 Grays (Gy) to about 10 Gy, e.g., about 1 Gy, 2 Gy, 3 Gy, 4 Gy, 6 Gy, 7 Gy, 8 Gy, 9 Gy, or another absorbed dose of ionizing radiation from about 0.5 Gy to about 10 Gy.

[0041] In some embodiments, the method also includes obtaining the biological sample from the irradiated subject prior to step (i) above.

[0042] In one embodiment, a whole blood sample, or other blood fraction containing lymphocytes, (including a finger stick or POC device) is collected from a subject known to be or suspected of being irradiated into a PAXGENE.TM. Blood RNA tube. The PAXGENE.TM. Blood RNA contains an additive that stabilizes in vitro gene expression and RNA degradation. Subsequently, RNA is extracted from the stabilized blood sample by using a Stabilized BLOOD-TO-CT.TM. Nucleic Acid Preparation Kit for qPCR (Life Technologies, Inc.). The RNA sample is then subjected to reverse transcription, e.g., using the INVITROGEN.TM. SUPERSCRIPT.COPYRGT. VILO.TM. (Variable Input, Linear Output) cDNA synthesis kit (Life Technologies, Inc.) or equivalent kit. Afterwards, the resulting cDNA is pre-amplified using a TAQMAN.RTM. probe PreAmp Master Mix Kit (Life Technologies, Inc.) and the pre-amplified cDNA is then assayed by TAQMAN.COPYRGT. probe-based qPCR in a 96-well or 384-well format using QUANTSTUDIO.TM. Dx or ABI7500 Fast Dx quantitative Real-Time PCR Instruments (Life Technologies, Inc.). Typically, expression levels of RM mRNAs will be expressed as a difference in C.sub.T between a test gene and a reference ("housekeeping") gene C.sub.T.

[0043] In some embodiments the panel of RM mRNAs to be assayed include at least some combination of mRNAs for one or all of the following (human) genes: CR2 (SEQ ID NO: 1), DHRS4L1 (SEQ ID NO: 2), HCK (SEQ ID NO: 3), IL1RAP (SEQ ID NO: 4), LYRM4 (SEQ ID NO: 5), MYC (SEQ ID NO: 6), TMEM63B (SEQ ID NO: 7), ALOX5 (SEQ ID NO: 8), CAMK4 (SEQ ID NO: 9), CDKN1A (SEQ ID NO: 10), COCH (SEQ ID NO: 11), DHRS4 (SEQ ID NO: 12), MICAL1 (SEQ ID NO: 13), MOB3B (SEQ ID NO: 14), NUSAP1 (SEQ ID NO: 15), IL27RA (SEQ ID NO: 16), HBA2 (SEQ ID NO: 17), PPM1F (SEQ ID NO: 18), PPP2RA (SEQ ID NO: 19), CLAR (SEQ ID NO: 20), DHRS13 (SEQ ID NO: 21), ACAA1 (SEQ ID NO: 22), INPP5J (SEQ ID NO: 23), OAZ1 (SEQ ID NO: 24), PNOC (SEQ ID NO: 25), PDE4B (SEQ ID NO: 26), SCARB1 (SEQ ID NO: 27), TMEM9B (SEQ ID NO: 28), CXXC5 (SEQ ID NO: 29), CD97 (SEQ ID NO: 30), TEX10 (SEQ ID NO: 31), SPECC1 (SEQ ID NO: 32), ALAS2 (SEQ ID NO: 33), ALPK1 (SEQ ID NO: 34), ESD (SEQ ID NO: 35), GPR183 (SEQ ID NO: 36), ESD (SEQ ID NO: 37), PPMK (SEQ ID NO: 38), and SLC6A6 (SEQ ID NO: 39) (collectively, SEQ ID NOs: 1-39).

[0044] In other embodiments RM mRNAs to be assayed can include at least some combination of one or all of the following genes: ADAM17, AKT1, ANK, ANXA3, ARHGAP26, ARID4A, ATG2A, ATIC, BCL11A, BCL6, BID, CFLAR, CIT, CPVL, CYTH4, DDB2, DDX58, DTL, EHBPL1, FCGR2A, FGR, HPRT1, HSP90AB1, HTRA2, IDOL, IRF1, JMJD1C, KIAA0101, LARP4B, LRRC6, LYN, MAP3K1, MAPK3, MDM1, MKNK1, MXD1, NAIP, NFE2L2, NRG1, NUSAP, PCNA, PGK1, PMP22, RARA, RNASE6, RPL13A, RPL6, RPS14, SP10, SPOCK2, TAPBP, TBP, TCF3, TNFRSF1A, TNFRSF1B, TNFSF14, USP38, WDR48, XAF1, ZAK, NPM, CPSF1, COASY, DNAJC10, DYNLRB1, ELK4, GPRIN, NDE1, PGS1, PPM1K, and PTAFR. In some embodiments, the reference gene to be assayed is PPP6R3. In other embodiments the reference gene to be assayed may be USP38, WDR48 or LARP4B or some combination thereof.

[0045] In some embodiments, qPCR reactions are multiplexed such that multiple mRNAs (including a reference mRNA) are assayed in a single qPCR reaction.

[0046] Also disclosed herein is a method for radiation treatment triage of a subject in need thereof, which includes the steps of: (i) determining the mRNA expression levels of mRNAs comprising the nucleotide sequences referred to in any of SEQ ID NOS: 1-39 (or any combination of any other SEQ ID NO provided herein) in a biological sample comprising mRNA from the subject to obtain an expression profile; and (ii) providing a suitable treatment for radiation exposure to the subject based on the expression levels of the genes. Exemplary treatments for radiation exposure based on radiation dosage are shown in Table 1 below:

TABLE-US-00001 TABLE 1 Exemplary treatments for radiation exposure based on radiation dosage. Very Symptoms and Mild Moderate Severe severe Lethal (a) treatment strategy (1-2 Gy) (2-4 Gy) (4-6 Gy) (6-8 Gy) (>8 Gy) Vomiting Onset After 2 hr. After 1-2 Within Within 30 Within 10 min. Incidence 10-50% hrs. 1 hr. min. 100% 70-90% 100% 100% Diarrhea Onset None None Mild Heavy Heavy Incidence 3-8 hrs. 1-3 hrs. Within min. -1 hr. <10% >10% almost 100% Headache Onset Slight Mild Moderate Severe Severe Incidence 4-24 hrs. 3-4 hrs. 1-2 hrs. 50% 80% 80-90% Conscious- Onset Alert Alert Alert Possibility Unconsciousness ness Incidence of by order of seconds impairment or minutes Seconds-minutes 100% (>50 Gy) Body Onset Normal Increased Fever High fever High fever Temperature Incidence 1-3 hrs. 1-2 hrs. <1 hrs. <1 hrs. 10-80% 80-100% 100% 100% Treatment Outpatient Observation Treatment Treatment Palliative treatment Strategy observation at general at at (a) (advanced hospital, specialized specialized medical care treatment at Hospital hospital including stem cell specialized transplantation) hospital if required

[0047] Also described herein is a radiation biodosimetry assay system that includes multiple nucleic acid amplification reactions containing the following: (i) mRNA or cDNA from a human subject suspected of suffering from radiation exposure; (ii) primer pairs capable of hybridizing under stringent conditions to mRNAs or cDNAs comprising the nucleotide sequences referred to in SEQ ID NOS: 1-39 (or any other SEQ ID NO provided herein), or the complementary sequences thereof, wherein each primer pair hybridizes to a different one of the mRNAs or cDNAs; and (iii) A mathematical algorithm the converts gene expression results to estimated absorbed dose of radiation.

[0048] In one embodiment, the mathematical algorithm of the present invention The Radiation Biodosimetry Absorbed Dose Estimation algorithm described herein takes as input sample qPCR data, sample barcode, and available information about the date and time of the exposure event and sample collection. The primary output of the algorithm is an absorbed dose report that contains an estimated absorbed dose and a dose interval that provides a range of dose values for the patient based on prediction intervals. The algorithm contains 6 basic steps, which are summarized in Table 2.

[0049] In Step 1, patient qPCR data are combined with the available information about the date and time of the event and sample collection using the patient barcode.

[0050] In Step 2, several quality control metrics are calculated for the qPCR data. Depending on the values of these metrics, the algorithm may determine that a sample requires re-testing. If the sample does not require re-testing, the quality control metrics will be utilized in the estimation of absorbed radiation dose, and in particular may affect the estimation interval.

[0051] In step 3, the qPCR data are checked against expected ranges for each biomarker.

[0052] In step 4, quality control metrics and the results of the biomarker range checks are used to determine whether specific biomarker values are invalid and whether sufficient biomarker values are valid for dose estimation.

[0053] In step 5, the qPCR data and the available temporal information for the event and sample collection are processed through a random forest-based mathematical algorithm that yields an estimated dose and a dose interval. The mathematical algorithm in Step 5 utilizes Random Forests.TM. method, introduced by Breiman (2001). Random forests is a popular machine-learning tool for prediction that combines large numbers of classification or regression trees to yield accurate and robust predictions. A random forest is a collection of classification or regression trees that we denote by R={T.sub.1, . . . , T.sub.n}. The input to the forest is a vector X of relative and/or absolute expression levels of a set of genes. In a regression random forest, each tree T.sub.i takes X as input and outputs an estimate of absorbed dose, T.sub.i(X). For example, FIG. 8 depicts a single tree in a random forest that utilizes the relative expression levels for two gene biomarkers (HBA2 and IL27RA) and the absolute expression level for one gene biomarker (COCH). The estimate of absorbed dose from a regression random forest R is then the average of estimated absorbed doses from the trees within the forest. We write this estimate as:

A D = R ( X ) = 1 n .times. i = 1 n T i ( X ) ##EQU00001##

[0054] In a classification random forest, samples are partitioned into several non-intersecting groups. For example, samples may be partitioned based upon dose and each group then represents an interval for the absorbed dose. Each tree T.sub.i takes as input X and outputs the identity of a single group, T.sub.i(X). The output from the classification random forest is a probability distribution on the set of groups, where the probability assigned to each group is the proportion of trees that yield the group.

[0055] The inputs to the mathematical algorithm in Step 5 are a set of absolute and relative expression levels, X for a set of genes, and a probability distribution w that reflects the uncertainty in D, the duration of time from irradiation to sample collection. If the duration of time is known precisely, w will be a point mass distribution on that known duration of time. If the duration is only known to fall within an interval, then may be any probability distribution on that interval such as a uniform distribution or a symmetric triangular distribution. If the duration is entirely unknown or not provided, then w may be calculated using a classification random forest that takes as input X and yields as output a probability distribution over a fixed set of duration values.

[0056] The outputs are an estimated absorbed dose, AD and a 95% prediction interval for the absorbed dose, (AD.sub.low, AD.sub.high). For NHP samples that were irradiated with a single acute dose (NHP SD), these outputs are computed in two steps. First, we compute an initial estimate of absorbed dose, AD. Secondly, we correct for bias in the estimate to yield the final estimate of absorbed dose, AD and generate the 95% prediction interval.

[0057] A novel aspect of our algorithm is the use of multiple random forests for each of several fixed durations, D.sub.1, . . . , D.sub.k. For duration D.sub.i, we use n.sub.i random forests, denoted by RF.sub.i,1, . . . , RF.sub.i,n.sub.i, to construct initial estimates of absorbed dose. A decision tree T.sub.i combines the outputs from RF.sub.i,1, . . . , RF.sub.i,n.sub.i into a single initial estimate of absorbed dose. One additional random forest, denoted by RF.sub.i.sup.E, is a quantile regression random forest for error that uses the expression values X' and the output from T.sub.i for bias correction and construction of prediction intervals. These n.sub.i+1 random forests utilize different, but possibly overlapping sets of genes, may be trained on different sets of samples and may include both regression forests and classification forests. Hence, if the duration is known to equal D.sub.i, the initial estimate of absorbed dose, denoted by AD.sup.I (D.sub.i), is computed as:

AD.sup.I(D.sub.i)=T.sub.i(RF.sub.i,1(X'), . . . ,RF.sub.i,n.sub.i(X'))

[0058] This estimate and the transformed expression levels X' are then passed to the random forest RF.sub.i.sup.E. The output from RF.sub.i.sup.E is the conditional probability distribution for the error in the estimate AD.sup.I(D.sub.i). We denote the cumulative distribution function for this conditional distribution by F( |D=D.sub.i). The bias corrected estimate of absorbed dose is then AD(D.sub.i)=AD.sup.I(D.sub.i)-F.sup.-1(0.5). If the duration is known to equal D* where D.sub.i<D*<D.sub.i+1, the estimated absorbed dose is computed as:

A D ( D * ) = D i + 1 - D * D i + 1 - D i .times. A D ( D i ) + D * - D i D i + 1 - D i .times. A D ( D i + 1 ) ##EQU00002##

[0059] The final estimate of absorbed dose is computed by averaging over the probability distribution .pi., that is, AD=.intg.AD(D).times..pi.(D)dD.

[0060] Similarly, we define F( |D=D*) by:

F ( | D = D * ) = D i + 1 - D * D i + 1 - D i .times. F ( | D = D i ) + D * - D i D i + 1 - D i .times. F ( | D = D i + 1 ) ##EQU00003##

[0061] The 95% prediction interval for the absorbed dose is then found by solving the equations:

.intg.F(e.sub.1|D).times..pi.(D)dD=0.025, and

.intg.F(e.sub.2|D).times.n(D)dD=0.975

for e.sub.1 and e.sub.2, respectively, and setting AD.sub.low=AD-e.sub.2 and AD.sub.high=AD-e.sub.1.

[0062] In step 6, an absorbed dose estimation report is constructed utilizing the estimated dose and dose interval.

[0063] In actual events of acute radiation exposure, to predict absorbed dose of human samples with the NHP-based biodosimetry algorithm, conceptually, gene expression measurements of each biomarker in a human sample need to be transformed by cross-species (i.e. human to NHP) algorithms. Ideal cross-conversion models could be built on two directly comparable single-dose (SD) data sets in human and NHP. However, due to practical difficulties in obtaining human blood samples with single acute irradiation, as an alternative, we obtain samples from human subjects who undergo total body irradiation (TBI). Unlike the acute single-dose (SD) irradiation that we used for development of a biodosimetry algorithm, these subjects under a fractionated dose (FD) schedule were irradiated three times (1.2 Gy each) a day for 6 days. Therefore, we obtained gene expression data from NHP-equivalents of human TBI subjects that underwent the identical fractionated irradiation, and developed novel gene-specific cross-species conversion algorithms. These algorithms will be used to transform human values prior to dose prediction (FIG. 9).

[0064] Unlike SD models that measure gene expression levels over the time after a single acute irradiation, data from a FD model has a linear relationship between cumulative dose and day. Therefore, prior to development of cross-species conversion algorithms based on human and NHP FD data sets, we first examined whether expression profiles of biomarker genes in NHP FD model were comparable to those in NHP SD model and thus could predict absorbed dose via the NHP SD model-based biodosimetry algorithm. For meta analyses of FD and SD data sets, we developed a three-dimensional (3D) curve fitting strategy to match the FD data to the SD data. Specifically, for each biomarker b we generate an FD curve of the mean expression level of NHP FD samples (2 Gy per day for 6 days) as a function of cumulative dose and day, FD.sub.b (dose, clay), and a SD response surface of the mean expression level of NHP SD samples (0 to 6 days, 0 to 7 Gy) as a function of dose and day, SD.sub.b(dose, clay) (FIG. 10A). First, the entire FD curve for each biomarker is shifted to match the mean basal level (i.e. 0 Gy/Day 0) of SD values, which produces a scaling factor .alpha..sub.b for expression values for each biomarker. The shifted FD curve is denoted FD.sub.b'(close, clay)=FD.sub.b(dose, clay)+.alpha..sub.b, where .alpha..sub.b=SD.sub.b(0, 0)-FD.sub.b(0, 0). Second, for each biomarker, optimal biomarker-specific dose and day scaling factors .beta..sub.b,dose and .beta..sub.b,day, are found that minimize the sum of absolute differences between the SD and scaled FD data.

[0065] Specifically, .beta..sub.b,dose and .beta..sub.b,day minimize the following expression,

d1 , d 2 FD b ' ( d 1 , d 2 ) FD b ' ( 12 , 6 ) .times. S D b ( .beta. b , dose .times. d 1 , .beta. b , day .times. d 2 ) - SD b ( .beta. b , dose .times. d 1 , .beta. b , day .times. d 2 ) ##EQU00004##

[0066] By repeating this for all biomarkers and searching for common dose and day scaling factors that minimize the sum of absolute differences across biomarkers, doses and days, unified FD to SD scaling factors of .beta..sub.dose=0.517 for dose (i.e. 12 Gy to 6.2 Gy) and .beta..sub.day=0.933 for day (i.e. day 6 to day 5.6) (FIG. 10B) are obtained.

[0067] Mathematically, .beta..sub.dose and .beta..sub.day are defined to minimize

.SIGMA. b .SIGMA. d 1 , d 2 F D b ' ( d 1 , d 2 ) F D b ' ( 12 , 6 ) .times. S D b ( .beta. d o s e .times. d 1 , .beta. d a y .times. d 2 ) - S D b ( .beta. d o s e .times. d 1 , .beta. d a y .times. d 2 ) . ##EQU00005##

[0068] Third, linear transformation of FD curves by the scaling factors yields the converted expression values,

FD b '' ( d 1 , d 2 ) = F D b ' ( d 1 , d 2 ) F D b ' ( 1 2 , 6 ) .times. S D b ( .beta. d o s e .times. d 1 , .beta. d a y .times. d2 ) . ( FIG . 10 A ) ##EQU00006##

[0069] To test the conversion strategy from NHP FD to NHP SD data, based on seven biomarkers (COCH, DHRS4L1, IL27RA, INPP5J, PNOC, SCARB1, and TEX10 in this example) with correlated dose responses between the data sets, random forests dose prediction models were generated on NHP SD data, which showed 84% to 98% dose prediction accuracy across days for the model fitting on NHP SD data (FIG. 11A). When expression values of NHP FD data were converted by matching days or doses and then applied to the NHP SD random forests model, dose prediction accuracies within 1.0 Gy were only 21% and 31%, respectively. After the FD values were transformed by the 3D scaling factors (i.e. for expression value, dose, and day), the accuracy was increased to 60% (FIG. 11B).

[0070] To increase performance of conversion algorithm, we explored a multi-gene regression approach that utilizes linear combinations of gene expression values rather than the expression values of individual biomarkers. This concept has been applied to predict missing values in large gene expression data sets. Since the biomarkers are functionally related within the key biological pathways related to radiation response, we hypothesized that expression profiles of other biomarkers could be informative in predicting expression values of a given gene. We employed Ridge regressions that provide robustness by constraining the size of coefficients by minimizing the summed squares of residuals and coefficients. By using converted NHP FD values by 3D scaling, a multi-gene regression model for each biomarker was generated with all seven genes that were used to build NHP SD biodosimetry algorithm. When the predicted values by the multi-gene regression models were applied to NHP SD algorithm, dose prediction accuracy was increased substantially to 86% (FIG. 11B).

[0071] Absolute gene expression values of biomarker genes are highly variable between NHP and human, and, thus, using an NHP biodosimetry algorithm to predict absorbed dose in human requires another step of cross-species expression value transformation from human to NHP. To explore the conversion strategies, we compared two data sets, for human and NHP, that were obtained from subjects treated with an identical irradiation schedule (3 times of irradiation at 1.2 Gy per day for 4 days), which is being used for total body irradiation (TBI) in clinical therapeutic setting. Among 29 biomarkers tested, although 17 genes had inter-species correlation coefficient above 0.6 between these two data sets (FIG. 12A), many genes showed substantial differences in absolute expression levels across doses (FIG. 12B). Therefore, we calculated the mean difference of expression for each biomarker and then applied the value to shift the entire expression values the gene across doses. This process decreased the mean absolute differences to less than 1.0 .DELTA.Ct for the majority of 29 biomarkers (FIG. 12A, last two columns).

[0072] To test the conversion strategy from human TBI to NHP FD data, based on 10 biomarkers (DHRS4L1, MYC, SPECC1, CXXC5, ALAS2, HBA2, CDKN1A, GPR183, MOB3B, and PNOC in this example) with inter-species correlation above 0.75 (FIG. 12A), random forests dose prediction models were generated on NHP FD data, which showed a 98% dose prediction accuracy during the model fitting on NHP FD data (FIG. 13A). Appling the converted human TBI values to NHP FD random forests model, prediction accuracy within 1.0 Gy was 13%. When expression values of human TBI data were vertically shifted by the predetermined shift factors and then applied to the NHP FD random forests model, dose prediction accuracies within 1.0 Gy was increase marginally to 19%.

[0073] We then tested whether the multi-gene regression approaches could improve the cross-species conversion process. As previously done for NHP FD to NHP SD conversion, we also employed Ridge regressions. By using converted human TBI values by vertical shifting factors, a multi-gene regression model for each biomarker was generated with all 10 genes that were used to build the NHP FD biodosimetry algorithm in this example. When the predicted values by the multi-gene regression models were applied to NHP FD algorithm, dose prediction accuracy was increased substantially to 89%.

TABLE-US-00002 TABLE 2 Algorithm Function. Step 1 Combine Traceability Barcode Unique barcode Adds all needed Flags data for operator Patient information to intervention Barcode with qPCR data Date/Time Event Step 2 Quality Control Negative 96-Well Prep Plate No Ct (Ref)(2) > 37 Cross- Retest Samples Check Control Template Control Contamination in (NTC) or Reagent Sample Prep Blank Positive qPCR Standard 1. Ct (Ref) .+-. 1 1. LLOD Verified Flags data - may affect Controls Curve: 10, 0.1, 0.01, each conc. 2. Reproducibility Dose Estimate and 0.001 ng/.mu.L 2. Amplification Verified Dose interval (Based on standard Efficiency 3. Amplification Or pooled RNA). verifies Require sample retest expected qPCR and function across Alerts Operator (No linear range. operator override) Evogenous Control: Ct (Xeno .TM.) .+-. 1 Inhibitors Sample RNA Spike-in Sample Integrity Endogenous Control Ct (Ref) .+-. 1 1. Adequate Reference Gene(1) Sample RNA Input. 2. Control for variable RNA Input. Step 3 Biomarker Process QC Biomarker integrity QC flag Usability of each Range Check Biomarker Value Step 4 Apply QC and Process QC Analytical integrity QC flag Usability of each Biomarker Biomarker Value Range Flags Step 5 Calculate Quantitative Endogenous Control Absorbed dose Estimated Checks for intended Estimated (Gy) absorbed Dose use dose range Dose Calculate Dose Measurement Confidence Interval Dose Range Dose Interval Checks for acceptable Interval Confidence confidence interval Step 5 Combine Report Report Gy Dose Estimation Clinic Estimated Report Review/Approval Dose and Dose Interval

[0074] In one embodiment, the target mRNAs or cDNAs to which the primers hybridize are those from the following (human) RM genes: CR2, DHRS4L1, HCK, IL1RAP, LYRM4, MYC, TMEM63B, ALOX5, CAMK4, CDKN1A, COCH, DHRS4, MICAL1, MOB3B, NUSAP1, IL27RA, HBA2, PPM1F, PPP2R1A, CFLAR, DHRS13, ACAA1, INPP5J, OAZ1, PNOC, PDE4B, SCARB1, and TMEM9B.

[0075] In other embodiments, mRNAs or cDNAs to which primers hybridize may include the following genes: ADAM17, AKT1, ANK1, ANXA3, ARHGAP26, ARID4A, ATG2A, ATIC, BCL11A, BCL6, BID, CFLAR, CIT, CPVL, CYTH4, DDB2, DDX58, DTL, EHBPL1, FCGR2A, FGR, HPRT1, HSP90AB1, HTRA2, IDOL, IL27RA, IRF1, JMJD1C, KIAA0101, LARP4B, LRRC6, LYN, MAP3K11, MAPK3, MDM1, MKNK1, MXD1, NAIP, NFE2L2, NRG1, NUSAP, PCNA, PGK1, PMP22, PPP2RA1, RARA, RNASE6, RPL13A, RPL6, RPS14, SCARB1, SP110, SPOCK2, TAPBP, TBP, TCF3, TNFRSF1A, TNFRSF1B, TNFSF14, USP38, WDR48, XAF1, ZAK, NPM1, ALAS2, ALPK1, CD97, CPSF1, COASY, CXXC5, DNAJC10, DYNLRB1, ELK4, ESD, GPR183, GPRIN, NDE1, PGS1, PPM1K, PTAFR, SLC6A6, SPECC1, and TEX10.

[0076] In some embodiments, primers are also included that hybridize to PPP6R3 mRNA or cDNA, where PPP6R3 and its mRNA levels serve as a reference gene for relative quantification of RM gene expression levels in an amplification reaction. In other embodiments primers may be included that hybridize to USP38, WDR48 or LARP4B mRNA or cDNA to serve as the reference gene or some combination thereof.

[0077] In some embodiments, the nucleic acid amplification reactions are qPCR reactions. In some embodiments the qPCR reactions are TAQMAN.RTM. probe qPCR reactions that include, in addition to the target primer pairs, TAQMAN.RTM. probes that hybridize under stringent conditions to the RM gene or reference gene mRNAs or cDNAs. TAQMAN.RTM. probe-based qPCR assays are well known in the art as described in, e.g., U.S. Pat. Nos. 5,677,152, 5,773,258 and 5,804,375.

[0078] Exemplary RM and reference gene primer and TAQMAN.RTM. probe sequences are listed below in Table 3.

TABLE-US-00003 TABLE 3 RM and reference gene primer and TAQMAN .RTM. probe sequences. Amplicon Length Gene Assay ID Sequence (bp) Tm PPP6R3 Hs00217759_ml TGAGGGAGGAAG 75 55-65.degree. C. ACGGCATGGTTA CATGGGACACCT AACGAGGATAGC TAACTGTATCGT GCACAGCACTGA CAAG CDKN1A Hs00217759_ml GACAGATTTCTA 63 55-65.degree. C. CCACTCCAAACG CCGGCTGATCTT CTCCAAGAGGAA GCCCTAATCCGC CCACAG

[0079] Typically, stringent hybridization reaction conditions are defined by use of TAQPATH.TM. qPCR Mastermix chemistry and cycling conditions listed below in Table 4.

TABLE-US-00004 TABLE 4 Thermal Cycling Conditions for Target/ Primer/Probe Hybridization. PCR Cycle (40 cycles) Incubation Activation Anneal/ Step Hold Hold Denature Extend Temperature 50.degree. C. 95.degree. C. 95.degree. C. 60.degree. C. Time 2 min. 20 sec. 1 sec. 20 sec. Volume 10 .mu.L

[0080] In some embodiments the plurality of nucleic acid amplification reactions are multiplexed such that multiple mRNAs (including a reference mRNA) are assayed in a single qPCR reaction, i.e., nine qPCR reactions would be needed to assay the entire panel of RM gene mRNAs from one sample, where each of the reactions are "tetraplexed," 14 reactions would be needed per sample where each reaction is "triplexed", and 28 reactions would be needed per sample when each qPCR reactions includes primers to a single RM gene mRNA and a reference gene mRNA. In some embodiments, the plurality of qPCR reactions can include different multiplexing, i.e., some reactions may contain primer pairs directed to three RM gene mRNAs and others a primer pair to only two or a single RM gene mRNA. The plurality of reactions can be provided in a number of formats, e.g., 96-, 384-, or even 1536-well formats.

[0081] In various embodiments, the mRNA or cDNA in the biodosimetry assay system is from a biological sample from a subject subjected to radiation exposure from about 30 minutes to about seven days prior to the time point at which the biological sample was obtained from the subject, e.g., one hour, three hours, 4 hours, six hours, twelve hours, 1 day, 2 days, 3 days, 4 days, 5 days, 7 days or another time period before biological sample collection from the subject ranging from about 30 minutes to about seven days.

[0082] Also contemplated herein is a radiation biomarker assay kit that includes a nucleic acid probe set consisting essentially of nucleic acid probes that hybridize specifically with nucleic acid targets comprising at least one of SEQ ID NOS: 1-39 or the complementary sequences thereof.

[0083] In some embodiments the probe set includes no more than about 200 probes, e.g., PCR primers. In other embodiments the probe set includes no more than about 100 probes.

[0084] In some embodiments the nucleic acid probe set includes primer pairs and TAQMAN.RTM. probes suitable for qPCR analysis of mRNAs or cDNAs comprising at least one of SEQ ID NOS: 1-39.

[0085] In some embodiments the kit also includes a thermostable polymerase suitable for qPCR, e.g., Taq polymerase and variants thereof known in the art.

[0086] In some embodiments a qPCR probe set in the kit is provided in a multi-well plate format. In some a multi-well plate is provided in which at least two nucleic acid probes that hybridize to at least two different nucleic acid targets are in the same wells, i.e., the probes can be multiplexed, as described above such that up to four different targets can be assayed by qPCR in the same reaction.

[0087] In some embodiments the kit also includes radiation exposure positive and negative control mRNA samples, which ensure that a qPCR biodosimetry assay is working properly, i.e., modulation of RM gene expression is detected in the positive control sample and no modulation of RM gene expression is detected in the negative control sample.

EXAMPLES

[0088] The invention will be more fully understood upon consideration of the following non-limiting Examples. The invention has been described in connection with what are presently considered to be the most practical and preferred embodiments. However, the present invention has been presented by way of illustration and is not intended to be limited to the disclosed embodiments. Accordingly, those skilled in the art will realize that the invention is intended to encompass all modifications and alternative arrangements within the spirit and scope of the invention as set forth in the appended claims.

Example 1: Description of Test Experiments Used to Develop Biomarkers

[0089] Rhesus macaque non-human primate (NHP) in vivo testing was conducted to produce single-dose biodosimetry samples and age/gender confounded samples to calibrate the biodosimeter.

[0090] NHP in vivo dose response to radiation: The animal test laboratory completed NHP Cobalt-60 irradiations at 0, 2, 4, and 6 (LD30/60), 7 Gy (LD70/60), and 10 Gy with cohorts of 16 (8 male and 8 female), at dose rate of approximately 0.6 Gy/min. Samples of 2.5 ml peripheral blood (PAXGENE.TM. blood RNA tube) were obtained from each rhesus macaque -2 week and -24 hr. prior to irradiation and 4 hr., 24 hr., 36 hr. post radiation, and on days 2, 3, 5, and 7 for a total of 9 blood draws per animal. Samples (0.5 ml) were also obtained in EDTA tubes to determine WBC differentials. Tests were staged to provide 4 NHP at each condition to determine target genes using discovery techniques (Phase 1), 10 NHP at each condition to determine biomarkers and 2 NHP at each condition to test the biodosimeter (algorithm) accuracy (Phase 2).

[0091] NHP confounder analysis; old age and juvenile. The animal test laboratory completed testing of 4 rhesus macaques (2 male and 2 female) exposed to 6 Gy (LD30/60) at a dose rate of approximately 0.6 Gy/min for both geriatric (>15 years) and juvenile (10-14 months) cohorts. Samples of 2.5 ml peripheral blood (PAXGENE.TM. blood RNA tube) were collected from each NHP -2 week and -24 hr. prior to irradiation and 4 hr., 24 hr., 36 hr. post radiation, and on days 2, 3, 5, and 7 for a total of 9 blood draws per animal. Samples (0.5 ml) were also obtained in EDTA tubes to determine WBC differentials.

[0092] NHP Fractionated Dose Testing: Two NHP models were developed to compare NHP gene response to human gene response for fractionated dose radiotherapy models.

[0093] NHP Fractionated Dose Models: Blood (2.5 ml) was collected from 6 female and 6 male rhesus NHP into PAXGENE.TM. blood RNA tubes. The NHP were irradiated in vivo to parallel the 4 human in vivo test protocols as described below. For Study 1: Twelve (12) NHPs were exposed to 1.5 Gy twice per day (dose rate 0.6-0.8 Gy/min.) for 4 days at the same time each day. The blood samples were collected within 24 hr. prior to irradiation and 24 hrs. after each daily exposure (6 draws). For Study 2: Twelve (12) NHPs were exposed to 1.2 Gy (dose rate 0.6-0.8 Gy/min.) 3 times per day at the same time each day for 4-days. Blood samples were collected prior to irradiation and 24 hr. following each exposure (prior to the next exposure) for a total of 6 draws. The NHPs were irradiated by LINAC. At the time of sample collection, a complete differential white cell count was conducted.

[0094] Human Fractionated Dose Models: Four human in vivo models were co-developed with Mayo Clinic, City of Hope and Stanford to provide blood samples from humans undergoing whole body and fractional radiation.

[0095] Model 1--Bone Marrow Transplant Patients (BMT): Radiation dose is 1.65 to 2 Gy twice daily for 3 to 4 days. Samples are taken prior to and 24 hr. after daily irradiations. The last draw is on Day-7; 7 days after the first dose. (4-6 samples/Series).

[0096] Model 2--Bone Marrow Transplant Patients (BMT): Radiation dose is 1.2 Gy three times daily for 4 days. Samples are taken prior to and 24 hr. after irradiation daily irradiations. The last draw is on Day-3 or 4; 3 or 4 days after the first dose. (5-7 samples/Series).

[0097] Model 3--Bone Marrow Transplant Patients (BMT): Radiation dose is a single fraction related to models 1 and 2. Samples are taken prior to and every 24 hr. after irradiation. The last draw is on Day-6; 6 days after the first dose. (6-7 samples/Series).

[0098] Model 4--X-Ray Therapy (XRT) Patients (>7% bone marrow exposure): Radiation dose is 2-8 Gy each day for multiple days. Samples are taken prior to and 24 hr. after irradiation. The last draw is taken 7 days after the last exposure.

TABLE-US-00005 TABLE 5 Nucleotide Sequences of Biodosimetry Biomarker Genes CR2 (SEQ ID NO: 1; GenBank NM_001006658.2). ATTTAAGGGCCCGCCTCTCCTGGCTCACAGCTGCTTGCTGCTCCAGCCTTGCCCTCCC AGAGCTGCCGGACGCTCGCGGGTCTCGGAACGCATCCCGCCGCGGGGGCTTCGGCC GTGGCATGGGCGCCGCGGGCCTGCTCGGGGTTTTCTTGGCTCTCGTCGCACCGGGGG TCCTCGGGATTTCTTGTGGCTCTCCTCCGCCTATCCTAAATGGCCGGATTAGTTATTA TTCTACCCCCATTGCTGTTGGTACCGTGATAAGGTACAGTTGTTCAGGTACCTTCCGC CTCATTGGAGAAAAAAGTCTATTATGCATAACTAAAGACAAAGTGGATGGAACCTG GGATAAACCTGCTCCTAAATGTGAATATTTCAATAAATATTCTTCTTGCCCTGAGCCC ATAGTACCAGGAGGATACAAAATTAGAGGCTCTACACCCTACAGACATGGTGATTC TGTGACATTTGCCTGTAAAACCAACTTCTCCATGAACGGAAACAAGTCTGTTTGGTG TCAAGCAAATAATATGTGGGGGCCGACACGACTACCAACCTGTGTAAGTGTTTTCCC TCTCGAGTGTCCAGCACTTCCTATGATCCACAATGGACATCACACAAGTGAGAATGT TGGCTCCATTGCTCCAGGATTGTCTGTGACTTACAGCTGTGAATCTGGTTACTTGCTT GTTGGAGAAAAGATCATTAACTGTTTGTCTTCGGGAAAATGGAGTGCTGTCCCCCCC ACATGTGAAGAGGCACGCTGTAAATCTCTAGGACGATTTCCCAATGGGAAGGTAAA GGAGCCTCCAATTCTCCGGGTTGGTGTAACTGCAAACTTTTTCTGTGATGAAGGGTA TCGACTGCAAGGCCCACCTTCTAGTCGGTGTGTAATTGCTGGACAGGGAGTTGCTTG GACCAAAATGCCAGTATGTGAAGAAATTTTTTGCCCATCACCTCCCCCTATTCTCAA TGGAAGACATATAGGCAACTCACTAGCAAATGTCTCATATGGAAGCATAGTCACTTA CACTTGTGACCCGGACCCAGAGGAAGGAGTGAACTTCATCCTTATTGGAGAGAGCA CTCTCCGTTGTACAGTTGATAGTCAGAAGACTGGGACCTGGAGTGGCCCTGCCCCAC GCTGTGAACTTTCTACTTCTGCGGTTCAGTGTCCACATCCCCAGATCCTAAGAGGCC GAATGGTATCTGGGCAGAAAGATCGATATACCTATAACGACACTGTGATATTTGCTT GCATGTTTGGCTTCACCTTGAAGGGCAGCAAGCAAATCCGATGCAATGCCCAAGGC ACATGGGAGCCATCTGCACCAGTCTGTGAAAAGGAATGCCAGGCCCCTCCTAACAT CCTCAATGGGCAAAAGGAAGATAGACACATGGTCCGCTTTGACCCTGGAACATCTA TAAAATATAGCTGTAACCCTGGCTATGTGCTGGTGGGAGAAGAATCCATACAGTGTA CCTCTGAGGGGGTGTGGACACCCCCTGTACCCCAATGCAAAGTGGCAGCGTGTGAA GCTACAGGAAGGCAACTCTTGACAAAACCCCAGCACCAATTTGTTAGACCAGATGT CAACTCTTCTTGTGGTGAAGGGTACAAGTTAAGTGGGAGTGTTTATCAGGAGTGTCA AGGCACAATTCCTTGGTTTATGGAGATTCGTCTTTGTAAAGAAATCACCTGCCCACC ACCCCCTGTTATCTACAATGGGGCACACACCGGGAGTTCCTTAGAAGATTTTCCATA TGGAACCACGGTCACTTACACATGTAACCCTGGGCCAGAAAGAGGAGTGGAATTCA GCCTCATTGGAGAGAGCACCATCCGTTGTACAAGCAATGATCAAGAAAGAGGCACC TGGAGTGGCCCTGCTCCCCTGTGTAAACTTTCCCTCCTTGCTGTCCAGTGCTCACATG TCCATATTGCAAATGGATACAAGATATCTGGCAAGGAAGCCCCATATTTCTACAATG ACACTGTGACATTCAAGTGTTATAGTGGATTTACTTTGAAGGGCAGTAGTCAGATTC GTTGCAAAGCTGATAACACCTGGGATCCTGAAATACCAGTTTGTGAAAAAGGCTGC CAGTCACCTCCTGGGCTCCACCATGGTCGTCATACAGGTGGAAATACGGTCTTCTTT GTCTCTGGGATGACTGTAGACTACACTTGTGACCCTGGCTATTTGCTTGTGGGAAAC AAATCCATTCACTGTATGCCTTCAGGAAATTGGAGTCCTTCTGCCCCACGGTGTGAA GAAACATGCCAGCATGTGAGACAGAGTCTTCAAGAACTTCCAGCTGGTTCACGTGTG GAGCTAGTTAATACGTCCTGCCAAGATGGGTACCAGTTGACTGGACATGCTTATCAG ATGTGTCAAGATGCTGAAAATGGAATTTGGTTCAAAAAGATTCCACTTTGTAAAGTT ATTCACTGTCACCCTCCACCAGTGATTGTCAATGGGAAGCACACAGGCATGATGGCA GAAAACTTTCTATATGGAAATGAAGTCTCTTATGAATGTGACCAAGGATTCTATCTC CTGGGAGAGAAAAAATTGCAGTGCAGAAGTGATTCTAAAGGACATGGATCTTGGAG CGGGCCTTCCCCACAGTGCTTACGATCTCCTCCTGTGACTCGCTGCCCTAATCCAGA AGTCAAACATGGGTACAAGCTCAATAAAACACATTCTGCATATTCCCACAATGACAT AGTGTATGTTGACTGCAATCCTGGCTTCATCATGAATGGTAGTCGCGTGATTAGGTG TCATACTGATAACACATGGGTGCCAGGTGTGCCAACTTGTATCAAAAAAGCCTTCAT AGGGTGTCCACCTCCGCCTAAGACCCCTAACGGGAACCATACTGGTGGAAACATAG CTCGATTTTCTCCTGGAATGTCAATCCTGTACAGCTGTGACCAAGGCTACCTGCTGGT GGGAGAGGCACTCCTTCTTTGCACACATGAGGGAACCTGGAGCCAACCTGCCCCTC ATTGTAAAGAGGTAAACTGTAGCTCACCAGCAGATATGGATGGAATCCAGAAAGGG CTGGAACCAAGGAAAATGTATCAGTATGGAGCTGTTGTAACTCTGGAGTGTGAAGA TGGGTATATGCTGGAAGGCAGTCCCCAGAGCCAGTGCCAATCGGATCACCAATGGA ACCCTCCCCTGGCGGTTTGCAGATCCCGTTCACTTGCTCCTGTCCTTTGTGGTATTGC TGCAGGTTTGATACTTCTTACCTTCTTGATTGTCATTACCTTATACGTGATATCAAAA CACAGAGCACGCAATTATTATACAGATACAAGCCAGAAAGAAGCTTTTCATTTAGA AGCACGAGAAGTATATTCTGTTGATCCATACAACCCAGCCAGCTGATCAGAAGACA AACTGGTGTGTGCCTCATTGCTTGGAATTCAGCGGAATATTGATTAGAAAGAAACTG CTCTAATATCAGCAAGTCTCTTTATATGGCCTCAAGATCAATGAAATGATGTCATAA GCGATCACTTCCTATATGCACTTATTCTCAAGAAGAACATCTTTATGGTAAAGATGG GAGCCCAGTTTCACTGCCATATACTCTTCAAGGACTTTCTGAAGCCTCACTTATGAG ATGCCTGAAGCCAGGCCATGGCTATAAACAATTACATGGCTCTAAAAAGTTTTGCCC TTTTTAAGGAAGGCACTAAAAAGAGCTGTCCTGGTATCTAGACCCATCTTCTTTTTG AAATCAGCATACTCAATGTTACTATCTGCTTTTGGTTATAATGTGTTTTTAATTATCT AAAGTATGAAGCATTTTCTGGGGTTATGATGGCTTTACCTTTATTAGGAAGTATGGT TTTATTTTGATAGTAGCTTCCTCCTCTGGTGGTGTTAATCATTTCATTTTTACCCTTAC TTGGTTTGAGTTTCTCTCACATTACTGTATATACTTTGCCTTTCCATAATCACTCAGTG ATTGCAATTTGCACAAGTTTTTTTAAATTATGGGAATCAAGATTTAATCCTAGAGATT TGGTGTACAATTCAGGCTTTGGATGTTTCTTTAGCAGTTTTGTGATAAGTTCTAGTTG CTTGTAAAATTTCACTTAATAATGTGTACATTAGTCATTCAATAAATTGTAATTGTAA AGAAAACATACAAAAAAAAAAAAAAAA DHRS4L1 (SEQ ID NO: 2; GenBank NM_001277864.1). AGTCGGGCAGCTCTCCGGGCCGGCGTGGGAGCCCGCGCTCCAAAGCCCGGTGGGGG GAGGGGCGCTCACGCAACCGCCACTGTCTGGAGCGGGCTCGCCTCTGCGGCGGCAC TCACCGCCCGGGCTTTACTGAAGCGGAGTCTAGCATGTGCGGCTGCTCCACAGCGGT GTGGGTGGCGGCGGCTCCTCTGCAGCAGCCTCGGCAGTAGGGGTCACGGTGGCCAA GCCCACCGTGGAGCTCATCTGAGAGTTGTAAGGTACGGGACTGCCTCGGTCTTTGGG ACGCCCCGTCTGGTAGCATCCCAGATCCAGCACGTTCCTTCCGGCCCTGCACCCCGG CCCGGTGCCTCACACCCCGCTACCCCATGCATCCAGACTCTAAGGCAGCCCCTGCAT CTCAGTCCTGACATCGCTGTCCCTGGAGCATCCTCCGCTGGAGCTGGAGCTTGACAG GATCGGCTTCGCCGTCGCCCAGCGTCTGGCCCAAGACGGGGCCCACGTGGTAGTCA GCCGCCGGAAGCAGCAGAATGTGGACCAGGCAGTGGCCACGCTGCAGGGGGAGGG GCTGAGCATGACGGGCACTGTGTGCCATGTGGGGAAGATGAAGGACTGGGAGCGGC TGGTGGCCACAGTGAGCTGCAGGGAAATGGGCACAGAGCCAGGAGGTGGAAAAGG GAGCCAGCCTGAGCCTCCTTCCCTGCTTTCCTGGACAGCATTGGGCTTCAGTCCTTAC AATGTCAGTAAAACAGCCTTGCTGGGCCTCAACAAGACCTTGGCCATAGAGCTGGC CCCAAGGAACATTAGGGTGAACTGCCTAGCACCTGGACTTATCAAGACTAGCTTCAG CAGGATGCTCTGGATGGACAAGGAAAAAGAGGAAAGCATGAAAGAAACCCTGCGG ATAAGAAGGTTAGGCGAGCCAGAGGATTCTCTTGGCATCGTGTCTTTCCTGTGCTCT GAAGATGCCAGCTACCTCACTGGGGAAACAGTGATGGTGGGTGGAGGAACCCCGTC CCGCCTCTGAGGACCCGGAGACAGCCCACAGGCCAGAGTTGGGCTCTAGCTCCTGG TGCTGTTCCTGCATTCACCCACTGGCCTTTCCCACCTCTGCTCACCTTACTGTTCACC TCATCAAATCAGTTCTGCCCTGTGAAAAGATCCAGCCTTCCCTGCCGTCAAGGTGGT GTCTTACTCGGGATTCCTGCTGTTGTTGTGGCCTTGGGTAAAGGCCTCCCCTGAGAA CACAGGACAGGCCTGCTGACAAGGCTGAGTCTACCTTGGCAAAGACCAAGATATTT TTTGCCCAGGCCACTGGGGAATTTGAGGGGAGATGAGAGAGAAGGAAGCTGGAGTG GAAGGAGCAGAGTTGCAAATTAACAACTTGCAAATGAGGTGCAAATAAAATGCAGA TGATTGCGCGGCTTTGAATCGAAAAAAAAAAA HCK (SEQ ID NO: 3; GenBank NM_001172129.1). GGAGTTAGCCTCGCTCAGGGCGCGGCTAAGGCGCCCAGATGGCCTGCGGGCGCCAC CACGTCCCTGGTCCCAGCTCGGGAGCACATCAGAGGCTTAGAGGCGAGTGGGAAGG GACTCAGACAGTGCAGGACGAGAAACGCCCGCGGCACCAAAGCCCCTCAGAGCGTC GCCCCCGCCTCTAGTTCTAGAAAGTCAGTTTCCCGGCACTGGCACCCCGGAACCTCA GGGGCTGCCGAGCTGGGGGGGCGCTCAAGCTGCGAGGATCCGGGCTGCCCGCGAGA CGAGGAGCGGGCGCCCAGGATGGGGTGCATGAAGTCCAAGTTCCTCCAGGTCGGAG GCAATACATTCTCAAAAACTGAAACCAGCGCCAGCCCACACTGTCCTGTGTACGTGC CGGATCCCACATCCACCATCAAGCCGGGGCCTAATAGCCACAACAGCAACACACCA GGAATCAGGGAGGCAGGCTCTGAGGACATCATCGTGGTTGCCCTGTATGATTACGA GGCCATTCACCACGAAGACCTCAGCTTCCAGAAGGGGGACCAGATGGTGGTCCTAG AGGAATCCGGGGAGTGGTGGAAGGCTCGATCCCTGGCCACCCGGAAGGAGGGCTAC ATCCCAAGCAACTATGTCGCCCGCGTTGACTCTCTGGAGACAGAGGAGTGGTTTTTC AAGGGCATCAGCCGGAAGGACGCAGAGCGCCAACTGCTGGCTCCCGGCAACATGCT GGGCTCCTTCATGATCCGGGATAGCGAGACCACTAAAGGAAGCTACTCTTTGTCCGT GCGAGACTACGACCCTCGGCAGGGAGATACCGTGAAACATTACAAGATCCGGACCC TGGACAACGGGGGCTTCTACATATCCCCCCGAAGCACCTTCAGCACTCTGCAGGAGC TGGTGGACCACTACAAGAAGGGGAACGACGGGCTCTGCCAGAAACTGTCGGTGCCC TGCATGTCTTCCAAGCCCCAGAAGCCTTGGGAGAAAGATGCCTGGGAGATCCCTCG GGAATCCCTCAAGCTGGAGAAGAAACTTGGAGCTGGGCAGTTTGGGGAAGTCTGGA TGGCCACCTACAACAAGCACACCAAGGTGGCAGTGAAGACGATGAAGCCAGGGAG CATGTCGGTGGAGGCCTTCCTGGCAGAGGCCAACGTGATGAAAACTCTGCAGCATG

ACAAGCTGGTCAAACTTCATGCGGTGGTCACCAAGGAGCCCATCTACATCATCACG GAGTTCATGGCCAAAGGAAGCTTGCTGGACTTTCTGAAAAGTGATGAGGGCAGCAA GCAGCCATTGCCAAAACTCATTGACTTCTCAGCCCAGATTGCAGAAGGCATGGCCTT CATCGAGCAGAGGAACTACATCCACCGAGACCTCCGAGCTGCCAACATCTTGGTCTC TGCATCCCTGGTGTGTAAGATTGCTGACTTTGGCCTGGCCCGGGTCATTGAGGACAA CGAGTACACGGCTCGGGAAGGGGCCAAGTTCCCCATCAAGTGGACAGCTCCTGAAG CCATCAACTTTGGCTCCTTCACCATCAAGTCAGACGTCTGGTCCTTTGGTATCCTGCT GATGGAGATCGTCACCTACGGCCGGATCCCTTACCCAGGGATGTCAAACCCTGAAG TGATCCGAGCTCTGGAGCGTGGATACCGGATGCCTCGCCCAGAGAACTGCCCAGAG GAGCTCTACAACATCATGATGCGCTGCTGGAAAAACCGTCCGGAGGAGCGGCCGAC CTTCGAATACATCCAGAGTGTGCTGGATGACTTCTACACGGCCACAGAGAGCCAGTA CCAACAGCAGCCATGATAGGGAGGACCAGGGCAGGGCCAGGGGGTGCCCAGGTGG TGGCTGCAAGGTGGCTCCAGCACCATCCGCCAGGGCCCACACCCCCTTCCTACTCCC AGACACCCACCCTCGCTTCAGCCACAGTTTCCTCATCTGTCCAGTGGGTAGGTTGGA CTGGAAAATCTCTTTTTGACTCTTGCAATCCACAATCTGACATTCTCAGGAAGCCCCC AAGTTGATATTTCTATTTCCTGGAATGGTTGGATTTTAGTTACAGCTGTGATTTGGAA GGGAAACTTTCAAAATAGTGAAATGAATATTTAAATAAAAGATATAAATGCCAAAG TCTTTACCAAAAAAAAAAAAAAAAA IL1RAP (SEQ ID NO: 4; GenBank NM_002182.3). AAAGGGGGAAAAGAAAGTGCGGCGGAAAGTAAGAGGCTCACTGGGGAAGACTGCC GGGATCCAGGTCTCCGGGGTCCGCTTTGGCCAGAGGCGCGGAAGGAAGCAGTGCCC GGCGACACTGCACCCATCCCGGCTGCTTTTGCTGCGCCCTCTCAGCTTCCCAAGAAA GGCATCGTCATGTGATCATCACCTAAGAACTAGAACATCAGCAGGCCCTAGAAGCC TCACTCTTGCCCCTCCCTTTAATATCTCAAAGGATGACACTTCTGTGGTGTGTAGTGA GTCTCTACTTTTATGGAATCCTGCAAAGTGATGCCTCAGAACGCTGCGATGACTGGG GACTAGACACCATGAGGCAAATCCAAGTGTTTGAAGATGAGCCAGCTCGCATCAAG TGCCCACTCTTTGAACACTTCTTGAAATTCAACTACAGCACAGCCCATTCAGCTGGC CTTACTCTGATCTGGTATTGGACTAGGCAGGACCGGGACCTTGAGGAGCCAATTAAC TTCCGCCTCCCCGAGAACCGCATTAGTAAGGAGAAAGATGTGCTGTGGTTCCGGCCC ACTCTCCTCAATGACACTGGCAACTATACCTGCATGTTAAGGAACACTACATATTGC AGCAAAGTTGCATTTCCCTTGGAAGTTGTTCAAAAAGACAGCTGTTTCAATTCCCCC ATGAAACTCCCAGTGCATAAACTGTATATAGAATATGGCATTCAGAGGATCACTTGT CCAAATGTAGATGGATATTTTCCTTCCAGTGTCAAACCGACTATCACTTGGTATATG GGCTGTTATAAAATACAGAATTTTAATAATGTAATACCCGAAGGTATGAACTTGAGT TTCCTCATTGCCTTAATTTCAAATAATGGAAATTACACATGTGTTGTTACATATCCAG AAAATGGACGTACGTTTCATCTCACCAGGACTCTGACTGTAAAGGTAGTAGGCTCTC CAAAAAATGCAGTGCCCCCTGTGATCCATTCACCTAATGATCATGTGGTCTATGAGA AAGAACCAGGAGAGGAGCTACTCATTCCCTGTACGGTCTATTTTAGTTTTCTGATGG ATTCTCGCAATGAGGTTTGGTGGACCATTGATGGAAAAAAACCTGATGACATCACTA TTGATGTCACCATTAACGAAAGTATAAGTCATAGTAGAACAGAAGATGAAACAAGA ACTCAGATTTTGAGCATCAAGAAAGTTACCTCTGAGGATCTCAAGCGCAGCTATGTC TGTCATGCTAGAAGTGCCAAAGGCGAAGTTGCCAAAGCAGCCAAGGTGAAGCAGAA AGTGCCAGCTCCAAGATACACAGTGGAACTGGCTTGTGGTTTTGGAGCCACAGTCCT GCTAGTGGTGATTCTCATTGTTGTTTACCATGTTTACTGGCTAGAGATGGTCCTATTT TACCGGGCTCATTTTGGAACAGATGAAACCATTTTAGATGGAAAAGAGTATGATATT TATGTATCCTATGCAAGGAATGCGGAAGAAGAAGAATTTGTATTACTGACCCTCCGT GGAGTTTTGGAGAATGAATTTGGATACAAGCTGTGCATCTTTGACCGAGACAGTCTG CCTGGGGGAATTGTCACAGATGAGACTTTGAGCTTCATTCAGAAAAGCAGACGCCTC CTGGTTGTTCTAAGCCCCAACTACGTGCTCCAGGGAACCCAAGCCCTCCTGGAGCTC AAGGCTGGCCTAGAAAATATGGCCTCTCGGGGCAACATCAACGTCATTTTAGTACAG TACAAAGCTGTGAAGGAAACGAAGGTGAAAGAGCTGAAGAGGGCTAAGACGGTGC TCACGGTCATTAAATGGAAAGGGGAAAAATCCAAGTATCCACAGGGCAGGTTCTGG AAGCAGCTGCAGGTGGCCATGCCAGTGAAGAAAAGTCCCAGGCGGTCTAGCAGTGA TGAGCAGGGCCTCTCGTATTCATCTTTGAAAAATGTATGAAAGGAATAATGAAAAG GGTAAAAAGAACAAGGGGTGCTCCAGGAAGAAAGAGTCCCCCCAGTCTTCATTCGC AGTTTATGGTTTCATAGGCAAAAATAATGGTCTAAGCCTCCCAATAGGGATAAATTT AGGGTGACTGTGTGGCTGACTATTCTGCTTCCTCAGGCAACACTAAAGTTTAGAAAG ATATCATCAACGTTCTGTCACCAGTCTCTGATGCCACTATGTTCTTTGCAGGCAAAG ACTTGTTCAATGCGAATTTCCCCTTCTACATTGTCTATCCCTGTTTTTATATGTCTCCA TTCTTTTTAAAATCTTAACATATGGAGCAGCCTTTCCTATGAATTTAAATATGCCTTT AAAATAAGTCACTGTTGACAGGGTCATGAGTTTCCGAGTATAGTTTTCTTTTTATCTT ATTTTTACTCGTCCGTTGAAAAGATAATCAAGGCCTACATTTTAGCTGAGGATAATG AACTTTTTTCCTCATTCGGCTGTATAATACATAACCACAGCAAGACTGACATCCACTT AGGATGATACAAAGCAGTGTAACTGAAAATGTTTCTTTTAATTGATTTAAAGGACTT GTCTTCTATACCACCCTTGTCCTCATCTCAGGTAATTTATGAAATCTATGTAAACTTG AAAAATATTTCTTAATTTTTGTTTTTGCTCCAGTCAATTCCTGATTATCCACAGGTCA ACCCACATTTTTTCATTCCTTCTCCCTATCTGCTTATATCGCATTGCTCATTTAGAGTT TGCAGGAGGCTCCATACTAGGTTCAGTCTGAAAGAAATCTCCTAATGGTGCTATAGA GAGGGAGGTAACAGAAAGACTCTTTTAGGGCATTTTTCTGACTCATGAAAAGAGCA CAGAAAAGGATGTTTGGCAATTTGTCTTTTAAGTCTTAACCTTGCTAATGTGAATACT GGGAAAGTGATTTTTTCTCACTCGTTTTTGTTGCTCCATTGTAAAGGGCGGAGGTCA GTCTTAGTGGCCTTGAGAGTTGCTTTTGGCATTAATATTCTAAGAGAATTAACTGTAT TTCCTGTCACCTATTCACTAGTGCAGGAAATATACTTGCTCCAAATAAGTCAGTATG AGAAGTCACTGTCAATGAAAGTTGTTTTGTTTGTTTTCAGTAATATTTTGCTGTTTTT AAGACTTGGAAAACTAAGTGCAGAGTTTACAGAGTGGTAAATATCTATGTTACATGT AGATTATACATATATATACACACGTGTATATGAGATATATATCTTATATCTCCACAA ACACAAATTATATATATACATATCCACACACATACATTACATATATCTGTGTATATA AATCCACATGCACATGAAATATATATATATATATAATTTGTGTGTGTGTATGTGTAT GTATATGACTTTAAATAGCTATGGGTACAATATTAAAAACCACTGGAACTCTTGTCC AGTTTTTAAATTATGTTTTTACTGGAATGTTTTTGTGTCAGTGTTTTCTGTACATATTA TTTGTTAATTCACAGCTCACAGAGTGATAGTTGTCATAGTTCTTGCCTTCCCTAAGTT TATATAAATAACTTAAGTATTGCTACAGTTTATCTAGGTTGCAGTGGCATCTGCTGTG CACAGAGCTTCCATGGTCACTGCTAAGCAGTAGCCAGCCATCGGGCATTAATTGATT TCCTACTATATTCCCAGCAGACACATTTAGAAACTAAGCTATGTTAACCTCAGTGCT CAACTATTTGAACTGTTGAGTGATAAAGGAAACAAATATAACTGTAAATGAATCTTG GTATCCTGTGAAACAGAATAATTCGTAATTTAAGAAAGCCCTTATCCCGGTAACATG AATGTTGATGAACAAATGTAAAATTATATCCTATATTTAAGTACCCATAATAAATCA TTTCCCTCTATAAGTGTTATTGATTATTTTAAATTGAAAAAAGTTTCACTTGGATGAA AAAAGTAGAAAAGTAGGTCATTCTTGGATCTACTTTTTTTTAGCCTTATTAATATTTT TCCCTATTAGAAACCACAATTACTCCCTCTATTAACCCTTCACTTACTAGACCAGAA AAGAACTTATTCCAGATAAGCTTTGAATATCAATTCTTACATAAACTTTAGGCAAAC AGGGAATAGTCTAGTCACCAAAGGACCATTCTCTTGCCAATGCTGCATTCCTTTTGC ACTTTTGGATTCCATATTTATCCCAAATGCTGTTGGGCACCCCTAGAAATACCTTGAT GTTTTTTCTATTTATATGCCTGCCTTTGGTACTTAATTTTACAAATGCTGTAATATAA AGCATATCAAGTTTATGTGATACGTATCATTGCAAGAGAATTTGTTTCAAGATTTTTT TTTAATGTTCCAGAAGATGGCCAATAGAGAACATTCAAGGGAAATGGGGAAACATA ATTTAGAGAACAAGAACAAACCATGTCTCAAATTTTTTTAAAAAAAATTAATGGTTT TAAATATATGCTATAGGGACGTTCCATGCCCAGGTTAACAAAGAACTGTGATATATA GAGTGTCTAATTACAAAATCATATACGATTTATTTAATTCTCTTCTGTATTGTAACTT AGATGATTCCCAAGGACTCTAATAAAAAATCACTTCATTGTATTTGGAAACAAAAAC ATCATTCATTAATTACTTATTTTCTTTCCATAGGTTTTAATATTTTGAGAGTGTCTTTT TTATTTCATTCATGAACTTTTGTATTTTTCATTTTTCATTTGATTTGTAAATTTACTTAT GTTAAAAATAAACCATTTATTTTCAGCTTTGAATTTTAAAAAAAAAAAAAAAAAA LYRM4 (SEQ ID NO: 5; GenBank NM_020408.5). GAGCCCTGCCTGCGCCCGCCCCCGAAGCGGCGCGGGACGCCTGGCGCCGTCCGCGA TCCGCAGGGCTGCCCGCTTAGGCTTAGGCCCGGCCCGCTGGCAAAGCCGAGCCGCA GCATTTTATTTCGTTCGTGGTTTCCGCACAGGCTGGAGTTTCGTGGGTTGGGTCGTAC TTGGGACCTCGGCGAAGAGGACCCGTTTATTTTTTTTTCTTTCCAAAATGGCAGCCTC CAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTT CAGCGCCTACAATTACAGAACATATGCTGTCAGGAGGATAAGAGATGCCTTCAGAG AAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAG AGAGACCTTGGAGTAATTCGTCGACAGGTCCACATTGGCCAACTGTATTCAACTGAC AAGCTGATCATTGAGAATCGAGACATGCCCAGGACCTAGCAAGCCGGGGACCAGCC ACCAGTGGCGGCCAGGGACCACCTTCAGCATCCACTCTCTGTTTGAGATGGGGGCTC CCAAAACCAGCTTACAATAGCCTTTTGCGCTGCCTGTCCTGTGGGAGCTGATAAACC AAGTCACATTTGCATTCTGTTGCAGGCTTAGTGAAAAAGGACTGCTGTCTTTCCTTG GTTCAAGTGTTAGAATGGAGAGCTGGAGTTCGTTCAGAATAGTGCTGTGTGTTACCA CGTCTCCCCTGCACCCCATTCCTACCTTGTAGCTCATGACCATTGTGTATAGCATTTC TACACTTTGTTTCTTGGTCCTTGGCAATAAAAAGAATGATCTCCCTGAGCCTTTGACC CCAGATAAACCCCTCCCAATTAATGCATTTTCATTTCCTACTGATACAAGGCCTGGA GAGGGCTGTTGGGGGCCCTCAGGGAGGGTTCAACTCTGAGACGAGAACTGCCTTGG TGAAGGCAAGTTCAAGCACCACTTGAGACTGGGGGCAGCATGGAGTAGGGCAGGGC TACGGGGATACACGGTGCACCCTGCAACTTATACCTGAGCCCAGTACAACAAAGGT GACGGGTGTGTAGGTACACACCCAGAGATGGAGCACTGCAGATCAGCAACCTCAGC CCCACCTGGGAATTTGCTGGAAATGCAGGCTCAAGCCCCTCCCCACACCTGGTGAAT GAGAGAGCCCCAGCCTGACCCAAGCCCAGGGCGACTCCCATACCCTGAAGCCTGGG GCATGCTGGGCAGCACCGGTGCCCAAATCTGGCTGGTGGACAGAAGCACCTGGAGA

GTTGGAGAGCTTTTTAAAAAGACATCTCTCAGCACTTCCCTCTCTGCAGATTCTGACT CAGTAAGTGAGGGGTGAGGCACAGTCATTTTTCTCTATTCTGAAGCTCTCCCACTGT TTTCAATGTTTAACCAACTGGGGACCCCTGCTCTTTAAGTATATTACAGGTAATAAA GATATTGTTTGTATGCTTTTAAAAAAAAAAAAAAAAAA. MYC (SEQ ID NO: 6; GenBank NM_002467). GACCCCCGAGCTGTGCTGCTCGCGGCCGCCACCGCCGGGCCCCGGCCGTCCCTGGCT CCCCTCCTGCCTCGAGAAGGGCAGGGCTTCTCAGAGGCTTGGCGGGAAAAAGAACG GAGGGAGGGATCGCGCTGAGTATAAAAGCCGGTTTTCGGGGCTTTATCTAACTCGCT GTAGTAATTCCAGCGAGAGGCAGAGGGAGCGAGCGGGCGGCCGGCTAGGGTGGAA GAGCCGGGCGAGCAGAGCTGCGCTGCGGGCGTCCTGGGAAGGGAGATCCGGAGCG AATAGGGGGCTTCGCCTCTGGCCCAGCCCTCCCGCTGATCCCCCAGCCAGCGGTCCG CAACCCTTGCCGCATCCACGAAACTTTGCCCATAGCAGCGGGCGGGCACTTTGCACT GGAACTTACAACACCCGAGCAAGGACGCGACTCTCCCGACGCGGGGAGGCTATTCT GCCCATTTGGGGACACTTCCCCGCCGCTGCCAGGACCCGCTTCTCTGAAAGGCTCTC CTTGCAGCTGCTTAGACGCTGGATTTTTTTCGGGTAGTGGAAAACCAGCAGCCTCCC GCGACGATGCCCCTCAACGTTAGCTTCACCAACAGGAACTATGACCTCGACTACGAC TCGGTGCAGCCGTATTTCTACTGCGACGAGGAGGAGAACTTCTACCAGCAGCAGCA GCAGAGCGAGCTGCAGCCCCCGGCGCCCAGCGAGGATATCTGGAAGAAATTCGAGC TGCTGCCCACCCCGCCCCTGTCCCCTAGCCGCCGCTCCGGGCTCTGCTCGCCCTCCTA CGTTGCGGTCACACCCTTCTCCCTTCGGGGAGACAACGACGGCGGTGGCGGGAGCTT CTCCACGGCCGACCAGCTGGAGATGGTGACCGAGCTGCTGGGAGGAGACATGGTGA ACCAGAGTTTCATCTGCGACCCGGACGACGAGACCTTCATCAAAAACATCATCATCC AGGACTGTATGTGGAGCGGCTTCTCGGCCGCCGCCAAGCTCGTCTCAGAGAAGCTG GCCTCCTACCAGGCTGCGCGCAAAGACAGCGGCAGCCCGAACCCCGCCCGCGGCCA CAGCGTCTGCTCCACCTCCAGCTTGTACCTGCAGGATCTGAGCGCCGCCGCCTCAGA GTGCATCGACCCCTCGGTGGTCTTCCCCTACCCTCTCAACGACAGCAGCTCGCCCAA GTCCTGCGCCTCGCAAGACTCCAGCGCCTTCTCTCCGTCCTCGGATTCTCTGCTCTCC TCGACGGAGTCCTCCCCGCAGGGCAGCCCCGAGCCCCTGGTGCTCCATGAGGAGAC ACCGCCCACCACCAGCAGCGACTCTGAGGAGGAACAAGAAGATGAGGAAGAAATC GATGTTGTTTCTGTGGAAAAGAGGCAGGCTCCTGGCAAAAGGTCAGAGTCTGGATC ACCTTCTGCTGGAGGCCACAGCAAACCTCCTCACAGCCCACTGGTCCTCAAGAGGTG CCACGTCTCCACACATCAGCACAACTACGCAGCGCCTCCCTCCACTCGGAAGGACTA TCCTGCTGCCAAGAGGGTCAAGTTGGACAGTGTCAGAGTCCTGAGACAGATCAGCA ACAACCGAAAATGCACCAGCCCCAGGTCCTCGGACACCGAGGAGAATGTCAAGAGG CGAACACACAACGTCTTGGAGCGCCAGAGGAGGAACGAGCTAAAACGGAGCTTTTT TGCCCTGCGTGACCAGATCCCGGAGTTGGAAAACAATGAAAAGGCCCCCAAGGTAG TTATCCTTAAAAAAGCCACAGCATACATCCTGTCCGTCCAAGCAGAGGAGCAAAAG CTCATTTCTGAAGAGGACTTGTTGCGGAAACGACGAGAACAGTTGAAACACAAACT TGAACAGCTACGGAACTCTTGTGCGTAAGGAAAAGTAAGGAAAACGATTCCTTCTA ACAGAAATGTCCTGAGCAATCACCTATGAACTTGTTTCAAATGCATGATCAAATGCA ACCTCACAACCTTGGCTGAGTCTTGAGACTGAAAGATTTAGCCATAATGTAAACTGC CTCAAATTGGACTTTGGGCATAAAAGAACTTTTTTATGCTTACCATCTTTTTTTTTTCT TTAACAGATTTGTATTTAAGAATTGTTTTTAAAAAATTTTAAGATTTACACAATGTTT CTCTGTAAATATTGCCATTAAATGTAAATAACTTTAATAAAACGTTTATAGCAGTTA CACAGAATTTCAATCCTAGTATATAGTACCTAGTATTATAGGTACTATAAACCCTAA TTTTTTTTATTTAAGTACATTTTGCTTTTTAAAGTTGATTTTTTTCTATTGTTTTTAGAA AAAATAAAATAACTGGCAAATATATCATTGAGCCAAATCTTAAAAAAAAAAAAAAA TMEM63B (SEQ ID NO: 7; GenBank NM_018426.1). AACCCGGGGCTCCGAGCCGGAGCCGAGTCTGCGCCTGGGGGAGGACCATGCGGCAG TAGCAGCCATGCTGCCCTTTCTGCTGGCCACACTGGGCACCACAGCCCTCAACAACA GCAACCCCAAGGACTACTGCTACAGCGCCCGCATCCGCAGCACTGTCCTGCAGGGC CTGCCCTTTGGGGGCGTCCCCACCGTGCTGGCTCTCGACTTCATGTGCTTCCTTGCAC TGCTGTTCTTATTCTCTATCCTCCGGAAGGTGGCCTGGGACTATGGGCGGCTGGCCTT GGTGACAGATGCAGACAGGCTTCGGCGGCAGGAGAGGGACCGAGTGGAACAGGAA TATGTGGCTTCAGCTATGCACGGGGACAGCCATGACCGGTATGAGCGTCTCACCTCT GTCTCCAGCTCCGTTGACTTTGACCAAAGGGACAATGGTTTCTGTTCCTGGCTGACA GCCATCTTCAGGATAAAGGATGATGAGATCCGGGACAAATGTGGGGGCGATGCCGT GCACTACCTGTCCTTTCAGCGGCACATCATCGGGCTGCTGGTGGTTGTGGGCGTCCT CTCCGTAGGCATCGTGCTGCCTGTCAACTTCTCAGGGGACCTGCTGGAGAACAATGC CTACAGCTTTGGGAGAACCACCATTGCCAACTTGAAATCAGGGAACAACCTGCTATG GCTGCACACCTCCTTCGCCTTCCTGTATCTGCTGCTCACCGTCTACAGCATGCGTAGA CACACCTCCAAGATGCGCTACAAGGAGGATGATCTGGTGAAGCGGACCCTCTTCAT CAATGGAATCTCCAAATATGCAGAGTCAGAAAAGATCAAGAAGCATTTTGAGGAAG CCTACCCCAACTGCACAGTTCTCGAAGCCCGCCCGTGTTACAACGTGGCTCGCCTAA TGTTCCTCGATGCAGAGAGGAAGAAGGCCGAGCGGGGAAAGCTGTACTTCACAAAC CTCCAGAGCAAGGAGAACGTGCCTACCATGATCAACCCCAAGCCCTGTGGCCACCT CTGCTGCTGTGTGGTGCGAGGCTGTGAGCAGGTGGAGGCCATTGAGTACTACACAA AGCTGGAGCAGAAGCTGAAGGAAGACTACAAGCGGGAGAAGGAGAAGGTGAATGA GAAGCCTCTTGGCATGGCCTTTGTCACCTTCCACAATGAGACTATCACCGCCATCAT CCTGAAGGACTTCAACGTGTGTAAATGCCAGGGCTGCACCTGCCGTGGGGAGCCAC GCCCCTCATCCTGCAGCGAGTCCCTGCACATCTCCAACTGGACCGTGTCCTATGCCC CTGACCCTCAGAACATCTACTGGGAGCACCTCTCCATCCGAGGCTTCATCTGGTGGC TGCGCTGCCTGGTCATCAATGTCGTCCTCTTCATCCTCCTCTTCTTCCTCACCACTCC AGCCATCATCATCACCACCATGGACAAGTTCAACGTCACCAAGCCTGTGGAGTACCT CAACAACCCCATCATCACCCAGTTCTTCCCCACCCTGCTGCTGTGGTGCTTCTCGGCC CTCCTTCCCACCATCGTCTACTACTCAGCCTTCTTTGAAGCCCACTGGACACGCTCTG GGGAGAACAGGACAACCATGCACAAGTGCTACACTTTCCTCATCTTCATGGTGCTGC TCCTACCCTCGCTGGGACTGAGCAGCCTGGACCTCTTCTTCCGCTGGCTCTTTGATAA GAAATTCTTGGCTGAGGCAGCTATTCGGTTTGAGTGTGTGTTCCTGCCCGACAACGG CGCCTTCTTCGTGAACTACGTCATTGCCTCAGCCTTTATCGGCAACGCCATGGACCT GCTGCGCATCCCAGGCCTGCTCATGTACATGATCCGGCTCTGCCTGGCGCGCTCGGC CGCCGAGAGGCGCAACGTGAAGCGGCATCAGGCCTACGAGTTCCAGTTTGGCGCAG CCTACGCCTGGATGATGTGCGTCTTCACGGTGGTCATGACCTACAGTATCACCTGCC CCATCATCGTGCCCTTCGGGCTCATGTACATGCTGCTGAAGCACCTGGTAGACAGGT ACAATCTCTACTACGCCTACCTGCCGGCCAAGCTGGACAAGAAGATCCACTCGGGG GCTGTGAACCAGGTGGTGGCCGCGCCCATCCTCTGCCTCTTCTGGCTGCTCTTCTTTT CCACCATGCGCACGGGGTTCCTAGCTCCCACGTCTATGTTCACATTTGTGGTCCTGGT CATCACCATCGTCATCTGTCTCTGCCACGTCTGCTTTGGACACTTCAAATACCTCAGT GCCCACAACTACAAGATTGAGCACACGGAGACAGATACTGTGGACCCCAGAAGCAA TGGACGGCCCCCCACTGCTGCTGCTGTCCCCAAATCTGCGAAATACATCGCTCAGGT GCTGCAGGACTCAGAGGTGGACGGGGATGGGGATGGGGCTCCTGGGAGCTCAGGGG ATGAGCCCCCATCATCCTCATCCCAAGATGAGGAGTTGCTGATGCCACCCGACGCCC TCACGGACACAGACTTCCAGTCTTGCGAGGACAGCCTCATAGAGAATGAGATTCAC CAGTAAGGGGAGGGAGGGGCCCTGGAGGCCACATCCTGCCCCACCCCACCCCCACT CCCACGGACACTAAAACGCTAATAATTTATTAGATCTAAAGCCCCTTCCTCCCCAGC CCCTGCTTTCATTAAGGTATTTAAACTTGGGGGTTTCACTGCTCTCCCCCATGATGGA GGGAGGGAGCCCCCCAACCTCAGTGAGGAGAGCCCCGAGCCGGCCCCGGGGCAAA GAGGGGTGCAGAGGGAGTTCCCCCAGATCAGTACCCCCCACCCCTCCCCAGCTAGT AGCATGACCAGGAGAGGGTTAATGAGAGCCAAGAGGAGTACCTGGTGCACCTGGTG CCGGTGGCTGGAGACCTGGGGGGCAGGTGGATCTGGGGCTGTTCCCCCCCCTCCGTT TTTTCCACCCCACAGTTCCTCCTGGGATCTGGCCCTCCAGGGAAGTGGAGCCTCCAG CCCCTAGGGGATGCATGAGGGGGGAGGGGGTGCTGAGTGGGAGGAAGAGTCAGGC TCACAGCTGGGGTGGCCTGGGGGTGGGGGTGGGCAAGGCTGACACTGGAAAATGGG TTTTTGCACTGTTTTTTTTTTGGTTTTTTTGTTCTTTTTTGTTTTTTTCCTTTAAAATAA AAACAAAGAAAAGCTCTGAAAAAAAAAAAAAAAAA ALOX5 (SEQ ID NO: 8; GenBank NM_000698.3). CCGGGGCCAGGGACCAGTGGTGGGAGGAGGCTGCGGCGCTAGATGCGGACACCTG GACCGCCGCGCCGAGGCTCCCGGCGCTCGCTGCTCCCGCGGCCCGCGCCATGCCCTC CTACACGGTCACCGTGGCCACTGGCAGCCAGTGGTTCGCCGGCACTGACGACTACAT CTACCTCAGCCTCGTGGGCTCGGCGGGCTGCAGCGAGAAGCACCTGCTGGACAAGC CCTTCTACAACGACTTCGAGCGTGGCGCGGTGGATTCATACGACGTGACTGTGGACG AGGAACTGGGCGAGATCCAGCTGGTCAGAATCGAGAAGCGCAAGTACTGGCTGAAT GACGACTGGTACCTGAAGTACATCACGCTGAAGACGCCCCACGGGGACTACATCGA GTTCCCCTGCTACCGCTGGATCACCGGCGATGTCGAGGTTGTCCTGAGGGATGGACG CGCAAAGTTGGCCCGAGATGACCAAATTCACATTCTCAAGCAACACCGACGTAAAG AACTGGAAACACGGCAAAAACAATATCGATGGATGGAGTGGAACCCTGGCTTCCCC TTGAGCATCGATGCCAAATGCCACAAGGATTTACCCCGTGATATCCAGTTTGATAGT GAAAAAGGAGTGGACTTTGTTCTGAATTACTCCAAAGCGATGGAGAACCTGTTCATC AACCGCTTCATGCACATGTTCCAGTCTTCTTGGAATGACTTCGCCGACTTTGAGAAA ATCTTTGTCAAGATCAGCAACACTATTTCTGAGCGGGTCATGAATCACTGGCAGGAA GACCTGATGTTTGGCTACCAGTTCCTGAATGGCTGCAACCCTGTGTTGATCCGGCGC TGCACAGAGCTGCCCGAGAAGCTCCCGGTGACCACGGAGATGGTAGAGTGCAGCCT GGAGCGGCAGCTCAGCTTGGAGCAGGAGGTCCAGCAAGGGAACATTTTCATCGTGG ACTTTGAGCTGCTGGATGGCATCGATGCCAACAAAACAGACCCCTGCACACTCCAGT TCCTGGCCGCTCCCATCTGCTTGCTGTATAAGAACCTGGCCAACAAGATTGTCCCCA TTGCCATCCAGCTCAACCAAATCCCGGGAGATGAGAACCCTATTTTCCTCCCTTCGG ATGCAAAATACGACTGGCTTTTGGCCAAAATCTGGGTGCGTTCCAGTGACTTCCACG

TCCACCAGACCATCACCCACCTTCTGCGAACACATCTGGTGTCTGAGGTTTTTGGCA TTGCAATGTACCGCCAGCTGCCTGCTGTGCACCCCATTTTCAAGCTGCTGGTGGCAC ACGTGAGATTCACCATTGCAATCAACACCAAGGCCCGTGAGCAGCTCATCTGCGAG TGTGGCCTCTTTGACAAGGCCAACGCCACAGGGGGCGGTGGGCACGTGCAGATGGT GCAGAGGGCCATGAAGGACCTGACCTATGCCTCCCTGTGCTTTCCCGAGGCCATCAA GGCCCGGGGCATGGAGAGCAAAGAAGACATCCCCTACTACTTCTACCGGGACGACG GGCTCCTGGTGTGGGAAGCCATCAGGACGTTCACGGCCGAGGTGGTAGACATCTAC TACGAGGGCGACCAGGTGGTGGAGGAGGACCCGGAGCTGCAGGACTTCGTGAACGA TGTCTACGTGTACGGCATGCGGGGCCGCAAGTCCTCAGGCTTCCCCAAGTCGGTCAA GAGCCGGGAGCAGCTGTCGGAGTACCTGACCGTGGTGATCTTCACCGCCTCCGCCCA GCACGCCGCGGTCAACTTCGGCCAGTACGACTGGTGCTCCTGGATCCCCAATGCGCC CCCAACCATGCGAGCCCCGCCACCGACTGCCAAGGGCGTGGTGACCATTGAGCAGA TCGTGGACACGCTGCCCGACCGCGGCCGCTCCTGCTGGCATCTGGGTGCAGTGTGGG CGCTGAGCCAGTTCCAGGAAAACGAGCTGTTCCTGGGCATGTACCCAGAAGAGCAT TTTATCGAGAAGCCTGTGAAGGAAGCCATGGCCCGATTCCGCAAGAACCTCGAGGC CATTGTCAGCGTGATTGCTGAGCGCAACAAGAAGAAGCAGCTGCCATATTACTACTT GTCCCCAGACCGGATTCCGAACAGTGTGGCCATCTGAGCACACTGCCAGTCTCACTG TGGGAAGGCCAGCTGCCCCAGCCAGATGGACTCCAGCCTGCCTGGCAGGCTGTCTG GCCAGGCCTCTTGGCAGTCACATCTCTTCCTCCGAGGCCAGTACCTTTCCATTTATTC TTTGATCTTCAGGGAACTGCATAGATTGATCAAAGTGTAAACACCATAGGGACCCAT TCTACACAGAGCAGGACTGCACAGCGTCCTGTCCACACCCAGCTCAGCATTTCCACA CCAAGCAGCAACAGCAAATCACGACCACTGATAGATGTCTATTCTTGTTGGAGACAT GGGATGATTATTTTCTGTTCTATTTGTGCTTAGTCCAATTCCTTGCACATAGTAGGTA CCCAATTCAATTACTATTGAATGAATTAAGAATTGGTTGCCATAAAAATAAATCAGT TCATTTAAAATGAAAAAAAAAAAAAAAAAAAA CAMK4 (SEQ ID NO: 9; GenBank NM_001744.4). AGTCTCCCTCCAGCGGGCGGCGACTCCGGGTTCCCCCTCGCGCCCTCTCGCAGAGGC TCGCCCCCTTCCCCGCCCACCGTCCCTGCGAGCGCGGGCGGCGGCGGTGGGCGTGTG CGCGCGTGAAGGACGCCGCCTCTCTCTCGCTCCTGCGTTCGCAGGCGGCGGCTGGCG GCCGGCTTCTCGCTCGGGCAGCGGCGGCGGCGGCGGCGGCGGCTTCCGGAGTCCCG CTGCGAAGATGCTCAAAGTCACGGTGCCCTCCTGCTCCGCCTCGTCCTGCTCTTCGG TCACCGCCAGTGCGGCCCCGGGGACCGCGAGCCTCGTCCCGGATTACTGGATCGAC GGCTCCAACAGGGATGCGCTGAGCGATTTCTTCGAGGTGGAGTCGGAGCTGGGACG GGGTGCTACATCCATTGTGTACAGATGCAAACAGAAGGGGACCCAGAAGCCTTATG CTCTCAAAGTGTTAAAGAAAACAGTGGACAAAAAAATCGTAAGAACTGAGATAGGA GTTCTTCTTCGCCTCTCACATCCAAACATTATAAAACTTAAAGAGATATTTGAAACC CCTACAGAAATCAGTCTGGTCCTAGAACTCGTCACAGGAGGAGAACTGTTTGATAG GATTGTGGAAAAGGGATATTACAGTGAGCGAGATGCTGCAGATGCCGTTAAACAAA TCCTGGAGGCAGTTGCTTATCTACATGAAAATGGGATTGTCCATCGTGATCTCAAAC CAGAGAATCTTCTTTATGCAACTCCAGCCCCAGATGCACCACTCAAAATCGCTGATT TTGGACTCTCTAAAATTGTGGAACATCAAGTGCTCATGAAGACAGTATGTGGAACCC CAGGGTACTGCGCACCTGAAATTCTTAGAGGTTGTGCCTATGGACCTGAGGTGGACA TGTGGTCTGTAGGAATAATCACCTACATCTTACTTTGTGGATTTGAACCATTCTATGA TGAAAGAGGCGATCAGTTCATGTTCAGGAGAATTCTGAATTGTGAATATTACTTTAT CTCCCCCTGGTGGGATGAAGTATCTCTAAATGCCAAGGACTTGGTCAGAAAATTAAT TGTTTTGGATCCAAAGAAACGGCTGACTACATTTCAAGCTCTCCAGCATCCGTGGGT CACAGGTAAAGCAGCCAATTTTGTACACATGGATACCGCTCAAAAGAAGCTCCAAG AATTCAATGCCCGGCGTAAGCTTAAGGCAGCGGTGAAGGCTGTGGTGGCCTCTTCCC GCCTGGGAAGTGCCAGCAGCAGCCATGGCAGCATCCAGGAGAGCCACAAGGCTAGC CGAGACCCTTCTCCAATCCAAGATGGCAACGAGGACATGAAAGCTATTCCAGAAGG AGAGAAAATTCAAGGCGATGGGGCCCAAGCCGCAGTTAAGGGGGCACAGGCTGAG CTGATGAAGGTGCAAGCCTTAGAGAAAGTTAAAGGTGCAGATATAAATGCTGAAGA GGCCCCCAAAATGGTGCCCAAGGCAGTGGAGGATGGGATAAAGGTGGCTGACCTGG AACTAGAGGAGGGCCTAGCAGAGGAGAAGCTGAAGACTGTGGAGGAGGCAGCAGC TCCCAGAGAAGGGCAAGGAAGCTCTGCTGTGGGTTTTGAAGTTCCACAGCAAGATG TGATCCTGCCAGAGTACTAAACAGCTTCCTTCAGATCTGGAAGCCAAACACCGGCAT TTTATGTACTTTGTCCTTCAGCAAGAAAGGTGTGGAAGCATGATATGTACTATAGTG ATTCTGTTTTTGAGGTGCAAAAAACATACATATATACCAGTTGGTAATTCTAACTTC AATGCATGTGACTGCTTTATGAAAATAATAGTGTCTTCTATGGCATGTAATGGATAC CTAATACCGATGAGTTAAATCTTGCAAGTTAACACAACGTAACACTTAAAAGCATAC ATTTTCAGCAACCAGTGGCACATATTTGAAGTGAATAGTAGCAAATTGTTTTTGCTTT GAAAATCTAGCCATCCTACATCCTTTGGATTTCTTCACAAGGCAGTAATTCCTTTGAA CTACTGCTTAGCTAATACTAGGTAGTGCTAAAAGACATGTTCCCATAACTTTTACAA CATTTTACTTTTTATCATTGATGTGTTCAAACTGTTTACAAGGAGATGCTTATAGATG ATAGTTGTACATATGTGCAAAAAAAAATCCACTTGCAATGGTAAGAAATTGAAGTA TCCTTAAAGGCCATGAAGCCATATGTCCCTAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAA CDKN1A (SEQ ID NO: 10; NM_000389.4). GTTGTATATCAGGGCCGCGCTGAGCTGCGCCAGCTGAGGTGTGAGCAGCTGCCGAA GTCAGTTCCTTGTGGAGCCGGAGCTGGGCGCGGATTCGCCGAGGCACCGAGGCACT CAGAGGAGGCGCCATGTCAGAACCGGCTGGGGATGTCCGTCAGAACCCATGCGGCA GCAAGGCCTGCCGCCGCCTCTTCGGCCCAGTGGACAGCGAGCAGCTGAGCCGCGAC TGTGATGCGCTAATGGCGGGCTGCATCCAGGAGGCCCGTGAGCGATGGAACTTCGA CTTTGTCACCGAGACACCACTGGAGGGTGACTTCGCCTGGGAGCGTGTGCGGGGCCT TGGCCTGCCCAAGCTCTACCTTCCCACGGGGCCCCGGCGAGGCCGGGATGAGTTGG GAGGAGGCAGGCGGCCTGGCACCTCACCTGCTCTGCTGCAGGGGACAGCAGAGGAA GACCATGTGGACCTGTCACTGTCTTGTACCCTTGTGCCTCGCTCAGGGGAGCAGGCT GAAGGGTCCCCAGGTGGACCTGGAGACTCTCAGGGTCGAAAACGGCGGCAGACCAG CATGACAGATTTCTACCACTCCAAACGCCGGCTGATCTTCTCCAAGAGGAAGCCCTA ATCCGCCCACAGGAAGCCTGCAGTCCTGGAAGCGCGAGGGCCTCAAAGGCCCGCTC TACATCTTCTGCCTTAGTCTCAGTTTGTGTGTCTTAATTATTATTTGTGTTTTAATTTA AACACCTCCTCATGTACATACCCTGGCCGCCCCCTGCCCCCCAGCCTCTGGCATTAG AATTATTTAAACAAAAACTAGGCGGTTGAATGAGAGGTTCCTAAGAGTGCTGGGCA TTTTTATTTTATGAAATACTATTTAAAGCCTCCTCATCCCGTGTTCTCCTTTTCCTCTC TCCCGGAGGTTGGGTGGGCCGGCTTCATGCCAGCTACTTCCTCCTCCCCACTTGTCC GCTGGGTGGTACCCTCTGGAGGGGTGTGGCTCCTTCCCATCGCTGTCACAGGCGGTT ATGAAATTCACCCCCTTTCCTGGACACTCAGACCTGAATTCTTTTTCATTTGAGAAGT AAACAGATGGCACTTTGAAGGGGCCTCACCGAGTGGGGGCATCATCAAAAACTTTG GAGTCCCCTCACCTCCTCTAAGGTTGGGCAGGGTGACCCTGAAGTGAGCACAGCCTA GGGCTGAGCTGGGGACCTGGTACCCTCCTGGCTCTTGATACCCCCCTCTGTCTTGTG AAGGCAGGGGGAAGGTGGGGTCCTGGAGCAGACCACCCCGCCTGCCCTCATGGCCC CTCTGACCTGCACTGGGGAGCCCGTCTCAGTGTTGAGCCTTTTCCCTCTTTGGCTCCC CTGTACCTTTTGAGGAGCCCCAGCTACCCTTCTTCTCCAGCTGGGCTCTGCAATTCCC CTCTGCTGCTGTCCCTCCCCCTTGTCCTTTCCCTTCAGTACCCTCTCAGCTCCAGGTG GCTCTGAGGTGCCTGTCCCACCCCCACCCCCAGCTCAATGGACTGGAAGGGGAAGG GACACACAAGAAGAAGGGCACCCTAGTTCTACCTCAGGCAGCTCAAGCAGCGACCG CCCCCTCCTCTAGCTGTGGGGGTGAGGGTCCCATGTGGTGGCACAGGCCCCCTTGAG TGGGGTTATCTCTGTGTTAGGGGTATATGATGGGGGAGTAGATCTTTCTAGGAGGGA GACACTGGCCCCTCAAATCGTCCAGCGACCTTCCTCATCCACCCCATCCCTCCCCAG TTCATTGCACTTTGATTAGCAGCGGAACAAGGAGTCAGACATTTTAAGATGGTGGCA GTAGAGGCTATGGACAGGGCATGCCACGTGGGCTCATATGGGGCTGGGAGTAGTTG TCTTTCCTGGCACTAACGTTGAGCCCCTGGAGGCACTGAAGTGCTTAGTGTACTTGG AGTATTGGGGTCTGACCCCAAACACCTTCCAGCTCCTGTAACATACTGGCCTGGACT GTTTTCTCTCGGCTCCCCATGTGTCCTGGTTCCCGTTTCTCCACCTAGACTGTAAACC TCTCGAGGGCAGGGACCACACCCTGTACTGTTCTGTGTCTTTCACAGCTCCTCCCAC AATGCTGAATATACAGCAGGTGCTCAATAAATGATTCTTAGTGACTTTACTTGTAAA AAAAAAAAAAAAAAA COCH (SEQ ID NO: 11; AY358900.1). GGGGCCTTGCCTTCCGCACTCGGGCGCAGCCGGGTGGATCTCGAGCAGGTGCGGAG CCCCGGGCGGCGGGCGCGGGTGCGAGGGATCCCTGACGCCTCTGTCCCTGTTTCTTT GTCGCTCCCAGCCTGTCTGTCGTCGTTTTGGCGCCCCCGCCTCCCCGCGGTGCGGGG TTGCACACCGATCCTGGGCTTCGCTCGATTTGCCGCCGAGGCGCCTCCCAGACCTAG AGGGGCGCTGGCCTGGAGCAGCGGGTCGTCTGTGTCCTCTCTCCTCTGCGCCGCGCC CGGGGATCCGAAGGGTGCGGGGCTCTGAGGAGGTGACGCGCGGGGCCTCCCGCACC CTGGCCTTGCCCGCATTCTCCCTCTCTCCCAGGTGTGAGCAGCCTATCAGTCACCATG TCCGCAGCCTGGATCCCGGCTCTCGGCCTCGGTGTGTGTCTGCTGCTGCTGCCGGGG CCCGCGGGCAGCGAGGGAGCCGCTCCCATTGCTATCACATGTTTTACCAGAGGCTTG GACATCAGGAAAGAGAAAGCAGATGTCCTCTGCCCAGGGGGCTGCCCTCTTGAGGA ATTCTCTGTGTATGGGAACATAGTATATGCTTCTGTATCGAGCATATGTGGGGCTGC TGTCCACAGGGGAGTAATCAGCAACTCAGGGGGACCTGTACGAGTCTATAGCCTAC CTGGTCGAGAAAACTATTCCTCAGTAGATGCCAATGGCATCCAGTCTCAAATGCTTT CTAGATGGTCTGCTTCTTTCACAGTAACTAAAGGCAAAAGTAGTACACAGGAGGCC ACAGGACAAGCAGTGTCCACAGCACATCCACCAACAGGTAAACGACTAAAGAAAA CACCCGAGAAGAAAACTGGCAATAAAGATTGTAAAGCAGACATTGCATTTCTGATT GATGGAAGCTTTAATATTGGGCAGCGCCGATTTAATTTACAGAAGAATTTTGTTGGA AAAGTGGCTCTAATGTTGGGAATTGGAACAGAAGGACCACATGTGGGCCTTGTTCA AGCCAGTGAACATCCCAAAATAGAATTTTACTTGAAAAACTTTACATCAGCCAAAG

ATGTTTTGTTTGCCATAAAGGAAGTAGGTTTCAGAGGGGGTAATTCCAATACAGGAA AAGCCTTGAAGCATACTGCTCAGAAATTCTTCACGGTAGATGCTGGAGTAAGAAAA GGGATCCCCAAAGTGGTGGTGGTATTTATTGATGGTTGGCCTTCTGATGACATCGAG GAAGCAGGCATTGTGGCCAGAGAGTTTGGTGTCAATGTATTTATAGTTTCTGTGGCC AAGCCTATCCCTGAAGAACTGGGGATGGTTCAGGATGTCACATTTGTTGACAAGGCT GTCTGTCGGAATAATGGCTTCTTCTCTTACCACATGCCCAACTGGTTTGGCACCACA AAATACGTAAAGCCTCTGGTACAGAAGCTGTGCACTCATGAACAAATGATGTGCAG CAAGACCTGTTATAACTCAGTGAACATTGCCTTTCTAATTGATGGCTCCAGCAGTGT TGGAGATAGCAATTTCCGCCTCATGCTTGAATTTGTTTCCAACATAGCCAAGACTTTT GAAATCTCGGACATTGGTGCCAAGATAGCTGCTGTACAGTTTACTTATGATCAGCGC ACGGAGTTCAGTTTCACTGACTATAGCACCAAAGAGAATGTCCTAGCTGTCATCAGA AACATCCGCTATATGAGTGGTGGAACAGCTACTGGTGATGCCATTTCCTTCACTGTT AGAAATGTGTTTGGCCCTATAAGGGAGAGCCCCAACAAGAACTTCCTAGTAATTGTC ACAGATGGGCAGTCCTATGATGATGTCCAAGGCCCTGCAGCTGCTGCACATGATGCA GGAATCACTATCTTCTCTGTTGGTGTGGCTTGGGCACCTCTGGATGACCTGAAAGAT ATGGCTTCTAAACCGAAGGAGTCTCACGCTTTCTTCACAAGAGAGTTCACAGGATTA GAACCAATTGTTTCTGATGTCATCAGAGGCATTTGTAGAGATTTCTTAGAATCCCAG CAATAATGGTAACATTTTGACAACTGAAAGAAAAAGTACAAGGGGATCCAGTGTGT AAATTGTATTCTCATAATACTGAAATGCTTTAGCATACTAGAATCAGATACAAAACT ATTAAGTATGTCAACAGCCATTTAGGCAAATAAGCACTCCTTTAAAGCCGCTGCCTT CTGGTTACAATTTACAGTGTACTTTGTTAAAAACACTGCTGAGGCTTCATAATCATG GCTCTTAGAAACTCAGGAAAGAGGAGATAATGTGGATTAAAACCTTAAGAGTTCTA ACCATGCCTACTAAATGTACAGATATGCAAATTCCATAGCTCAATAAAAGAATCTGA TACTTAGACCAAAAAAAAAAA DHRS4 (SEQ ID NO: 12; NM_021004.3). CTACTCTGTCACCGCCCCTGGGAAGAGTGGAACCCATACTTGCTGGTCTGATCCATG CACAAGGCGGGGCTGCTAGGCCTCTGTGCCCGGGCTTGGAATTCGGTGCGGATGGC CAGCTCCGGGATGACCCGCCGGGACCCGCTCGCAAATAAGGTGGCCCTGGTAACGG CCTCCACCGACGGGATCGGCTTCGCCATCGCCCGGCGTTTGGCCCAGGACGGGGCCC ATGTGGTCGTCAGCAGCCGGAAGCAGCAGAATGTGGACCAGGCGGTGGCCACGCTG CAGGGGGAGGGGCTGAGCGTGACGGGCACCGTGTGCCATGTGGGGAAGGCGGAGG ACCGGGAGCGGCTGGTGGCCACGGCTGTGAAGCTTCATGGAGGTATCGATATCCTA GTCTCCAATGCTGCTGTCAACCCTTTCTTTGGAAGCATAATGGATGTCACTGAGGAG GTGTGGGACAAGACTCTGGACATTAATGTGAAGGCCCCAGCCCTGATGACAAAGGC AGTGGTGCCAGAAATGGAGAAACGAGGAGGCGGCTCAGTGGTGATCGTGTCTTCCA TAGCAGCCTTCAGTCCATCTCCTGGCTTCAGTCCTTACAATGTCAGTAAAACAGCCTT GCTGGGCCTGACCAAGACCCTGGCCATAGAGCTGGCCCCAAGGAACATTAGGGTGA ACTGCCTAGCACCTGGACTTATCAAGACTAGCTTCAGCAGGATGCTCTGGATGGACA AGGAAAAAGAGGAAAGCATGAAAGAAACCCTGCGGATAAGAAGGTTAGGCGAGCC AGAGGATTGTGCTGGCATCGTGTCTTTCCTGTGCTCTGAAGATGCCAGCTACATCAC TGGGGAAACAGTGGTGGTGGGTGGAGGAACCCCGTCCCGCCTCTGAGGACCGGGAG ACAGCCCACAGGCCAGAGTTGGGCTCTAGCTCCTGGTGCTGTTCCCGCATTCACCCA CTGGCCTTTCCCACCTCTGCTCACCTTACTGTTCACCTCATCAAATCAGTTCTGCCCT GTGAAAAGATCCAGCCTTCCCTGCCGTCAAGGTGGCGTCTTACTCGGGATTTCTGCT GTTGTTGTGGCCTTGGGTAAAGGCCTCCCCTGAGAACACAGGACAGGCCTGCTGACA AGGCTGAGTCTACCTTGGCAAAGACCAAGATATTTTTTCCCGGGCCACTGGGGAATC TGAGGGGTGATGGGAGAGAAGGAACCTGGAGTGGAAGGAGCAGAGTTGCAAATTA ACAACTTGCAAATGAGGTGCAAATAAAATGCAGATGATTGCGCGGCTTTGAATCCA AAAAAAAAAAAAAAAAA MICAL1 (SEQ ID NO: 13; NM_022765.3). CCCAAGACTGTCCCCGCTGGAGGCGGTAGAGGGATCCAGAAGTAATGAGATGCTAA TGAGTCGCGAATAAAGCCCGGGCGGCGCCCCGCGCCCCTCGCGGAAGCCCACACTC CGCGCGACTCCAGGCGCACGCCCCGGGCCGCCCCGCATCCCAGCATCCCCGCCCGA TCTCGGCGTTTCCGCCCCCGCCCCCGCCCCCGCCCTCCCACCCGCTCAGACCTGGTTG CCAGCCCAACAGGAAGCGGCCCCTCCCGGCTTCGGAGCCGCCGCCACTCATCTCTGC CCAGCTGCTGCCCTCCCCAGGAGGCCTCCATGGCTTCACCTACCTCCACCAACCCAG CGCATGCCCACTTTGAGAGCTTCCTGCAGGCCCAGCTGTGCCAGGACGTGCTGAGCA GCTTCCAGGAGCTGTGTGGGGCCCTGGGGCTGGAACCCGGTGGGGGGCTGCCCCAG TACCACAAGATCAAGGACCAGCTCAACTACTGGAGCGCCAAGTCACTGTGGACCAA GCTGGACAAGCGAGCAGGCCAGCCTGTCTACCAGCAGGGCCGGGCCTGCACCAGCA CCAAGTGCCTGGTGGTGGGTGCTGGACCTTGCGGGCTGCGGGTCGCTGTGGAGCTGG CGCTGCTGGGGGCCCGAGTGGTGCTGGTGGAAAAGCGCACCAAGTTCTCTCGCCAC AACGTGCTCCACCTCTGGCCCTTCACCATCCACGACCTGCGGGCACTCGGTGCTAAG AAGTTCTACGGGCGCTTCTGCACCGGCACCCTGGACCACATCAGCATCAGGCAGCTC CAGCTGCTTCTGCTGAAGGTAGCATTGCTGCTGGGGGTGGAAATTCACTGGGGTGTC ACTTTCACTGGCCTCCAGCCCCCTCCTAGGAAGGGGAGTGGCTGGCGTGCCCAGCTC CAACCCAACCCCCCTGCCCAGCTGGCCAACTATGAATTTGACGTCCTTATCTCGGCT GCAGGAGGTAAATTCGTCCCTGAAGGCTTCAAAGTTCGAGAAATGCGAGGCAAACT GGCCATTGGCATCACAGCCAACTTTGTGAATGGACGCACCGTGGAGGAGACACAGG TGCCGGAGATCAGTGGTGTAGCCAGGATCTACAACCAGAGCTTCTTCCAGAGCCTTC TCAAAGCCACAGGCATTGATCTGGAGAACATTGTGTACTACAAGGACGACACCCAC TACTTTGTGATGACAGCCAAGAAGCAGTGCCTGCTGCGGCTGGGGGTGCTGCGCCA GGACTGGCCAGACACCAATCGGCTGCTGGGCAGTGCCAATGTGGTGCCCGAGGCTC TGCAGCGCTTTACCCGGGCAGCTGCTGACTTTGCCACCCATGGCAAGCTCGGGAAAC TAGAGTTTGCCCAGGATGCCCATGGGCAGCCTGATGTCTCTGCCTTTGACTTCACGA GCATGATGCGGGCAGAGAGTTCTGCTCGTGTGCAAGAGAAGCATGGCGCCCGCCTG CTGCTGGGACTGGTGGGGGACTGCCTGGTGGAGCCCTTCTGGCCCCTGGGCACTGGA GTGGCACGGGGCTTCCTGGCAGCCTTTGATGCAGCCTGGATGGTGAAGCGGTGGGC AGAGGGCGCTGAGTCCCTAGAGGTGTTGGCTGAGCGTGAGAGCCTGTACCAGCTTCT GTCACAGACATCCCCAGAAAACATGCATCGCAATGTGGCCCAGTATGGGCTGGACC CAGCCACCCGCTACCCCAACCTGAACCTCCGGGCAGTGACCCCCAATCAGGTACGA GACCTGTATGATGTGCTAGCCAAGGAGCCTGTGCAGAGGAACAACGACAAGACAGA TACAGGGATGCCAGCCACCGGGTCGGCAGGCACCCAGGAGGAGCTGCTACGCTGGT GCCAGGAGCAGACAGCTGGGTACCCGGGAGTCCACGTCTCCGATTTGTCTTCCTCCT GGGCTGATGGGCTAGCTCTGTGTGCCCTGGTGTACCGGCTGCAGCCTGGCCTGCTGG AACCCTCAGAGCTGCAGGGGCTGGGAGCTCTGGAAGCAACTGCTTGGGCACTAAAG GTGGCAGAGAATGAGCTGGGCATCACACCGGTGGTGTCTGCACAGGCCGTGGTAGC AGGGAGTGACCCACTGGGCCTCATTGCCTACCTCAGCCACTTCCACAGTGCCTTCAA GAGCATGGCCCACAGCCCAGGCCCTGTCAGCCAGGCCTCCCCAGGGACCTCCAGTG CTGTATTATTCCTTAGTAAACTTCAGAGGACCCTGCAGCGATCCCGGGCCAAGGAAA ATGCAGAGGATGCTGGTGGCAAGAAGCTGCGCTTGGAGATGGAGGCCGAGACCCCA AGTACTGAGGTGCCACCTGACCCAGAGCCTGGTGTACCCCTGACACCCCCATCCCAA CACCAGGAGGCCGGTGCTGGGGACCTGTGTGCACTTTGTGGGGAACACCTCTATGTC CTGGAACGCCTCTGTGTCAACGGCCATTTCTTCCACCGGAGCTGCTTCCGCTGCCAT ACCTGTGAGGCCACACTGTGGCCAGGTGGCTACGAGCAGCACCCAGGAGATGGACA TTTCTACTGCCTCCAGCACCTGCCCCAGACAGACCACAAAGCGGAAGGCAGCGATA GAGGCCCTGAGAGTCCGGAGCTCCCCACACCAAGTGAGAATAGCATGCCACCAGGC CTCTCAACTCCCACAGCCTCGCAGGAGGGGGCCGGTCCTGTTCCAGATCCCAGCCAG CCCACCCGTCGGCAGATCCGCCTCTCCAGCCCGGAGCGCCAGCGGTTGTCCTCCCTT AACCTTACCCCTGACCCGGAAATGGAGCCTCCACCCAAGCCTCCCCGCAGCTGCTCC GCCTTGGCCCGCCACGCCCTGGAGAGCAGCTTTGTGGGCTGGGGCCTGCCAGTCCAG AGCCCTCAAGCTCTTGTGGCCATGGAGAAGGAGGAAAAAGAGAGTCCCTTCTCCAG TGAAGAGGAAGAAGAAGATGTGCCTTTGGACTCAGATGTGGAACAGGCCCTGCAGA CCTTTGCCAAGACCTCAGGCACCATGAATAACTACCCAACATGGCGTCGGACTCTGC TGCGCCGTGCGAAGGAGGAGGAGATGAAGAGGTTCTGCAAGGCCCAGACCATCCAA CGGCGACTAAATGAGATTGAGGCTGCCTTGAGGGAGCTAGAGGCCGAGGGCGTGAA GCTGGAGCTGGCCTTGAGGCGCCAGAGCAGTTCCCCAGAACAGCAAAAGAAACTAT GGGTAGGACAGCTGCTACAGCTCGTTGACAAGAAAAACAGCCTGGTGGCTGAGGAG GCCGAGCTCATGATCACGGTGCAGGAATTGAATCTGGAGGAGAAACAGTGGCAGCT GGACCAGGAGCTACGAGGCTACATGAACCGGGAAGAAAACCTAAAGACAGCTGCT GATCGGCAGGCTGAGGACCAGGTCCTGAGGAAGCTGGTGGATTTGGTCAACCAGAG AGATGCCCTCATCCGCTTCCAGGAGGAGCGCAGGCTCAGCGAGCTGGCCTTGGGGA CAGGGGCCCAGGGCTAGACGAGGGTGGGCCGTCTGCTTTCGTTCCCACAAAGAAAG CACCTCACCCCAGCACAGTGCCACCCCTGTTCATCTGGGCTGCCTGGCAGAGAGCCT TGCTGTTTACAATTAAAATGTTTCTGCCACAAAAAAAAAAAAAAAAAAA MOB3B (SEQ ID NO: 14; AJ580636.1). ATGTCCATAGCCCTGAAGCAGGTATTCAACAAGGACAAGACCTTCCGACCCAAGAG GAAATTTGAACCTGGCACACAGAGGTTTGAGCTGCACAAACGGGCTCAGGCATCCC TCAACTCGGGTGTGGACCTGAAGGCGGCTGTGCAGTTGCCCAGTGGGGAGGACCAG AATGACTGGGTGGCAGTACATGTGGTGGACTTCTTCAATCGGATCAACCTCATCTAT GGCACCATCTGTGAGTTCTGCACCGAGCGGACCTGTCCTGTGATGTCAGGGGGCCCC AAATATGAGTATCGGTGGCAGGATGATCTCAAGTATAAGAAGCCAACAGCGCTGCC AGCTCCCCAGTACATGAACCTTCTTATGGATTGGATTGAGGTTCAGATCAACAACGA GGAAATATTTCCAACATGCGTGGGTGTTCCCTTCCCAAAGAACTTCCTTCAGATCTG CAAGAAGATCCTGTGCCGCCTTTTCCGGGTCTTTGTCCACGTCTATATCCACCACTTC GACCGGGTCATTGTGATGGGTGCAGAGGCCCATGTCAACACCTGCTACAAACACTTC TATTACTTTGTCACAGAGATGAACCTCATAGACCGCAAGGAGCTAGAGCCTTTGAAA

GAAATGACGAGCAGGATGTGTCACTAA NUSAP1 (SEQ ID NO: 15; NM_016359.4). GCGTTACAGGCCCTTTGGCGCCTGCGTATTCGTGAAGTGTGAAAAAAGCGCGCCTCT GTTGGGACGGGAAATCAGCCTTTCTATTGGTCAGGGTTAGAAACCCCGCCTTTGAGG CATTTTCAACCAATGGAAGCGCGGCATTCTTCATTTAAACTGTCTATAAATTTCTGCC TAGTCAAAGTTAAGAGTGGCGCCAGGGATTTGAACCGCGCTGACGAAGTTTGGTGA TCCATCTTCCGAGTATCGCCGGGATTTCGAATCGCGATGATCATCCCCTCTCTAGAG GAGCTGGACTCCCTCAAGTACAGTGACCTGCAGAACTTAGCCAAGAGTCTGGGTCTC CGGGCCAACCTGAGGGCAACCAAGTTGTTAAAAGCCTTGAAAGGCTACATTAAACA TGAGGCAAGAAAAGGAAATGAGAATCAGGATGAAAGTCAAACTTCTGCATCCTCTT GTGATGAGACTGAGATACAGATCAGCAACCAGGAAGAAGCTGAGAGACAGCCACTT GGCCATGTCACCAAAACAAGGAGAAGGTGCAAGACTGTCCGTGTGGACCCTGACTC ACAGCAGAATCATTCAGAGATAAAAATAAGTAATCCCACTGAATTCCAGAATCATG AAAAGCAGGAAAGCCAGGATCTCAGAGCTACTGCAAAAGTTCCTTCTCCACCAGAC GAGCACCAAGAAGCTGAGAATGCTGTTTCCTCAGGTAACAGAGATTCAAAGGTACC TTCAGAAGGAAAGAAATCTCTCTACACAGATGAGTCATCCAAACCTGGAAAAAATA AAAGAACTGCAATCACTACTCCAAACTTTAAGAAGCTTCATGAAGCTCATTTTAAGG AAATGGAGTCCATTGATCAATATATTGAGAGAAAAAAGAAACATTTTGAAGAACAC AATTCCATGAATGAACTGAAGCAGCAGCCCATCAATAAGGGAGGGGTCAGGACTCC AGTACCTCCAAGAGGAAGACTCTCTGTGGCTTCTACTCCCATCAGCCAACGACGCTC GCAAGGCCGGTCTTGTGGCCCTGCAAGTCAGAGTACCTTGGGTCTGAAGGGGTCACT CAAGCGCTCTGCTATCTCTGCAGCTAAAACGGGTGTCAGGTTTTCAGCTGCTACTAA AGATAATGAGCATAAGCGTTCACTGACCAAGACTCCAGCCAGAAAGTCTGCACATG TGACCGTGTCTGGGGGCACCCCAAAAGGCGAGGCTGTGCTTGGGACACACAAATTA AAGACCATCACGGGGAATTCTGCTGCTGTTATTACCCCATTCAAGTTGACAACTGAG GCAACGCAGACTCCAGTCTCCAATAAGAAACCAGTGTTTGATCTTAAAGCAAGTTTG TCTCGTCCCCTCAACTATGAACCACACAAAGGAAAGCTAAAACCATGGGGGCAATC TAAAGAAAATAATTATCTAAATCAACATGTCAACAGAATTAACTTCTACAAGAAAA CTTACAAACAACCCCATCTCCAGACAAAGGAAGAGCAACGGAAGAAACGCGAGCA AGAACGAAAGGAGAAGAAAGCAAAGGTTTTGGGAATGCGAAGGGGCCTCATTTTGG CTGAAGATTAATAATTTTTTAACATCTTGTAAATATTCCTGTATTCTCAACTTTTTTCC TTTTGTAAATTTTTTTTTTTTGCTGTCATCCCCACTTTAGTCACGAGATCTTTTTCTGC TAACTGTTCATAGTCTGTGTAGTGTCCATGGGTTCTTCATGTGCTATGATCTCTGAAA AGACGTTATCACCTTAAAGCTCAAATTCTTTGGGATGGTTTTTACTTAAGTCCATTAA CAATTCAGGTTTCTAACGAGACCCATCCTAAAATTCTGTTTCTAGATTTTTAATGTCA AGTTCCCAAGTTCCCCCTGCTGGTTCTAATATTAACAGAACTGCAGTCTTCTGCTAGC CAATAGCATTTACCTGATGGCAGCTAGTTATGCAAGCTTCAGGAGAATTTGAACAAT AACAAGAATAGGGTAAGCTGGGATAGAAAGGCCACCTCTTCACTCTCTATAGAATA TAGTAACCTTTATGAAACGGGGCCATATAGTTTGGTTATGACATCAATATTTTACCT AGGTGAAATTGTTTAGGCTTATGTACCTTCGTTCAAATATCCTCATGTAATTGCCATC TGTCACTCACTATATTCACAAAAATAAAACTCTACAACTCATTCTAACATTGCTTACT TAAAAGCTACATAGCCCTATCGAAATGCGAGGATTAATGCTTTAATGCTTTTAGAGA CAGGGTCTCACTGTGTTGCCCAGGCTGGTCTCAAACTCCACCAAATGTACTTCTTATT CATTTTATGGAAAAGACTAGGCTTTGCTTAGTATCATGTCCATGTTTCCTTCACCTCA GTGGAGCTTCTGAGTTTTATACTGCTCAAGATCGTCATAAATAAAATTTTTTCTCATT GTCATAGAAAAAAAAAAAAAAAAAA IL27RA (SEQ ID NO: 16; NM_004843.3). GCGGAGGCGGCCTGCCGGGGTGGTTCGGCTTCCCGTTGCCGCCTCGGGCGCTGTACC CAGAGCTCGAAGAGGAGCAGCGCGGCCGCGCGGACCCGGCAAGGCTGGGCCGGAC TCGGGGCTCCCGAGGGACGCCATGCGGGGAGGCAGGGGCGCCCCTTTCTGGCTGTG GCCGCTGCCCAAGCTGGCGCTGCTGCCTCTGTTGTGGGTGCTTTTCCAGCGGACGCG TCCCCAGGGCAGCGCCGGGCCACTGCAGTGCTACGGAGTTGGACCCTTGGGCGACT TGAACTGCTCGTGGGAGCCTCTTGGGGACCTGGGAGCCCCCTCCGAGTTACACCTCC AGAGCCAAAAGTACCGTTCCAACAAAACCCAGACTGTGGCAGTGGCAGCCGGACGG AGCTGGGTGGCCATTCCTCGGGAACAGCTCACCATGTCTGACAAACTCCTTGTCTGG GGCACTAAGGCAGGCCAGCCTCTCTGGCCCCCCGTCTTCGTGAACCTAGAAACCCAA ATGAAGCCAAACGCCCCCCGGCTGGGCCCTGACGTGGACTTTTCCGAGGATGACCC CCTGGAGGCCACTGTCCATTGGGCCCCACCTACATGGCCATCTCATAAAGTTCTGAT CTGCCAGTTCCACTACCGAAGATGTCAGGAGGCGGCCTGGACCCTGCTGGAACCGG AGCTGAAGACCATACCCCTGACCCCTGTTGAGATCCAAGATTTGGAGCTAGCCACTG GCTACAAAGTGTATGGCCGCTGCCGGATGGAGAAAGAAGAGGATTTGTGGGGCGAG TGGAGCCCCATTTTGTCCTTCCAGACACCGCCTTCTGCTCCAAAAGATGTGTGGGTA TCAGGGAACCTCTGTGGGACGCCTGGAGGAGAGGAACCTTTGCTTCTATGGAAGGC CCCAGGGCCCTGTGTGCAGGTGAGCTACAAAGTCTGGTTCTGGGTTGGAGGTCGTGA GCTGAGTCCAGAAGGAATTACCTGCTGCTGCTCCCTAATTCCCAGTGGGGCGGAGTG GGCCAGGGTGTCCGCTGTCAACGCCACAAGCTGGGAGCCTCTCACCAACCTCTCTTT GGTCTGCTTGGATTCAGCCTCTGCCCCCCGTAGCGTGGCAGTCAGCAGCATCGCTGG GAGCACGGAGCTACTGGTGACCTGGCAACCGGGGCCTGGGGAACCACTGGAGCATG TAGTGGACTGGGCTCGAGATGGGGACCCCCTGGAGAAACTCAACTGGGTCCGGCTT CCCCCTGGGAACCTCAGTGCTCTGTTACCAGGGAATTTCACTGTCGGGGTCCCCTAT CGAATCACTGTGACCGCAGTCTCTGCTTCAGGCTTGGCCTCTGCATCCTCCGTCTGG GGGTTCAGGGAGGAATTAGCACCCCTAGTGGGGCCAACGCTTTGGCGACTCCAAGA TGCCCCTCCAGGGACCCCCGCCATAGCGTGGGGAGAGGTCCCAAGGCACCAGCTTC GAGGCCACCTCACCCACTACACCTTGTGTGCACAGAGTGGAACCAGCCCCTCCGTCT GCATGAATGTGAGTGGCAACACACAGAGTGTCACCCTGCCTGACCTTCCTTGGGGTC CCTGTGAGCTGTGGGTGACAGCATCTACCATCGCTGGACAGGGCCCTCCTGGTCCCA TCCTCCGGCTTCATCTACCAGATAACACCCTGAGGTGGAAAGTTCTGCCGGGCATCC TATTCTTGTGGGGCTTGTTCCTGTTGGGGTGTGGCCTGAGCCTGGCCACCTCTGGAA GGTGCTACCACCTAAGGCACAAAGTGCTGCCCCGCTGGGTCTGGGAGAAAGTTCCT GATCCTGCCAACAGCAGTTCAGGCCAGCCCCACATGGAGCAAGTACCTGAGGCCCA GCCCCTTGGGGACTTGCCCATCCTGGAAGTGGAGGAGATGGAGCCCCCGCCGGTTA TGGAGTCCTCCCAGCCCGCCCAGGCCACCGCCCCGCTTGACTCTGGGTATGAGAAGC ACTTCCTGCCCACACCTGAGGAGCTGGGCCTTCTGGGGCCCCCCAGGCCACAGGTTC TGGCCTGAACCACACGTCTGGCTGGGGGCTGCCAGCCAGGCTAGAGGGATGCTCAT GCAGGTTGCACCCCAGTCCTGGATTAGCCCTCTTGATGGATGAAGACACTGAGGACT CAGAGAGGCTGAGTCACTTACCTGAGGACACCCAGCCAGGCAGAGCTGGGATTGAA GGACCCCTATAGAGAAGGGCTTGGCCCCCATGGGGAAGACACGGATGGAAGGTGGA GCAAAGGAAAATACATGAAATTGAGAGTGGCAGCTGCCTGCCAAAATCTGTTCCGC TGTAACAGAACTGAATTTGGACCCCAGCACAGTGGCTCACGCCTGTAATCCCAGCAC TTTGGCAGGCCAAGGTGGAAGGATCACTTAGAGCTAGGAGTTTGAGACCAGCCTGG GCAATATAGCAAGACCCCTCACTACAAAAATAAAACATCAAAAACAAAAACAATTA GCTGGGCATGATGGCACACACCTGTAGTCCGAGCCACTTGGGAGGCTGAGGTGGGA GGATCGGTTGAGCCCAGGAGTTCGAAGCTGCAGGGACCTCTGATTGCACCACTGCA CTCCAGGCTGGGTAACAGAATGAGACCTTATCTCAAAAATAAACAAACTAATAAAA AGCAAAAAAAAAAAAAAAAAAAAAAAAAAAA HBA2 (SEQ ID NO: 17; NM_000517.4). CATAAACCCTGGCGCGCTCGCGGGCCGGCACTCTTCTGGTCCCCACAGACTCAGAGA GAACCCACCATGGTGCTGTCTCCTGCCGACAAGACCAACGTCAAGGCCGCCTGGGG TAAGGTCGGCGCGCACGCTGGCGAGTATGGTGCGGAGGCCCTGGAGAGGATGTTCC TGTCCTTCCCCACCACCAAGACCTACTTCCCGCACTTCGACCTGAGCCACGGCTCTG CCCAGGTTAAGGGCCACGGCAAGAAGGTGGCCGACGCGCTGACCAACGCCGTGGCG CACGTGGACGACATGCCCAACGCGCTGTCCGCCCTGAGCGACCTGCACGCGCACAA GCTTCGGGTGGACCCGGTCAACTTCAAGCTCCTAAGCCACTGCCTGCTGGTGACCCT GGCCGCCCACCTCCCCGCCGAGTTCACCCCTGCGGTGCACGCCTCCCTGGACAAGTT CCTGGCTTCTGTGAGCACCGTGCTGACCTCCAAATACCGTTAAGCTGGAGCCTCGGT AGCCGTTCCTCCTGCCCGCTGGGCCTCCCAACGGGCCCTCCTCCCCTCCTTGCACCG GCCCTTCCTGGTCTTTGAATAAAGTCTGAGTGGGCAGCAAAAAAAAAAAAAAAAAA PPM1F (SEQ ID NO: 18; NM_014634). AGGGACGGGAAGTGGGCGGGGCCGGCCGGCAGCAGCTTGCGGGACACGGAGCCGC GAGGAGACAGCTGAGGCCCGCGGAGACCAGGGGGTGAAGCCTGGAGACCCTCTTGC CCTGGCCTAGCTGCAGGCCCCCGGGATGCTTTGGGCATGTCCTCTGGAGCCCCACAG AAGAGCAGCCCAATGGCCAGTGGAGCTGAGGAGACCCCAGGCTTCCTGGACACGCT CCTGCAAGACTTCCCAGCCCTGCTGAACCCAGAGGACCCTCTGCCATGGAAGGCCCC AGGGACGGTGCTCAGCCAGGAGGAGGTGGAGGGCGAGCTGGCTGAGCTGGCCATG GGCTTTCTGGGCAGCAGGAAGGCCCCGCCACCACTTGCTGCTGCTCTGGCCCACGAA GCAGTTTCACAGCTGCTACAGACAGACCTTTCCGAATTCAGGAAGTTGCCCAGGGAG GAAGAAGAAGAGGAGGAGGACGATGACGAGGAGGAAAAGGCCCCTGTGACCTTGC TGGATGCCCAAAGCCTGGCACAGAGTTTCTTTAACCGCCTTTGGGAAGTCGCCGGCC AGTGGCAGAAGCAGGTGCCATTGGCTGCCCGGGCCTCACAGCGGCAGTGGCTGGTC TCCATCCACGCCATCCGGAACACTCGCCGCAAGATGGAGGACCGGCACGTGTCCCT CCCTTCCTTCAACCAGCTCTTCGGCTTGTCTGACCCTGTGAACCGCGCCTACTTTGCT GTGTTTGATGGTCACGGAGGCGTGGATGCTGCGAGGTACGCCGCTGTCCACGTGCAC ACCAACGCTGCCCGCCAGCCAGAGCTGCCCACAGACCCTGAGGGAGCCCTCAGAGA AGCCTTCCGGCGCACCGACCAGATGTTTCTCAGGAAAGCCAAGCGAGAGCGGCTGC AGAGCGGCACCACAGGTGTGTGTGCGCTCATTGCAGGAGCGACCCTGCACGTCGCC TGGCTCGGGGATTCCCAGGTCATTTTGGTACAGCAGGGACAGGTGGTGAAGCTGAT GGAGCCACACAGACCAGAACGGCAGGATGAGAAGGCGCGCATTGAAGCATTGGGT

GGCTTTGTGTCTCACATGGACTGCTGGAGAGTCAACGGGACCCTGGCCGTCTCCAGA GCCATCGGGGATGTCTTCCAGAAGCCCTACGTGTCTGGGGAGGCCGATGCAGCTTCC CGGGCGCTGACGGGCTCCGAGGACTACCTGCTGCTTGCCTGTGATGGCTTCTTTGAC GTCGTACCCCACCAGGAAGTTGTTGGCCTGGTCCAGAGCCACCTGACCAGGCAGCA GGGCAGCGGGCTCCGTGTCGCCGAGGAGCTGGTGGCTGCGGCCCGGGAGCGGGGCT CCCACGACAACATCACGGTCATGGTGGTCTTCCTCAGGGACCCCCAAGAGCTGCTGG AGGGCGGGAACCAGGGAGAAGGGGACCCCCAGGCAGAAGGGAGGAGGCAGGACTT GCCCTCCAGCCTTCCAGAACCTGAGACCCAGGCTCCACCAAGAAGCTAGGTGGTTTC CAGGCCCCTGCCCTCCCCTTCCTCCCATCCTTGTCCTTCTCTCCCTCAGAAGCCTCAG GACCCAACAGGTGGCAGGCAGTGGACAGGGTGCCCGCCCCACAGTGCTTTCCCCAG CACCCCAGAGCCAGTCGGGACACCCCCCGCAGCCCGTCCTGGTGGCTGTGGAACTG CACTGGGTGGCGGGCAGATGGTGGAAGGCAGCTTAGGAGACCTCACCAAAGAGAA GATGGACCGGCTCTTGCTCCCAGCTCCTATTAGGCCCGGGGTGGGACCAGAGGTCAT AGGTGCCCAACGGCAGCCAAACCAAAGACACTGGTGTGCATGGGGCAGCATGGTTG TGCACGTGGGACCCTGGGGCGGACCCAGGAGCCAAACTCTTGAAGCACCCCCTGGG TCAGGCCCAGCAGCGGAGTGGCCAGCCCCAGTTTCCCATTGCTCCTCTCTGCGGCCA GGGCCAGGTGGGTTCATATTTACAGATATGCCCAGCCAGTCCTGGTCGGCCACACCA GTGTCCCAAAGAGGAGAGCGCAGCAGAGCCAGGGGTCTGTTCTGTAGCAGCCACCC CCCTGCCCCCACTCCAGGGCAGCCATGATGTGCTTGGGCCCACCAGGGCCTTCCGGG CTGCTCTCTTCCCTGAGCCCGGAACCGGCGACGCACATGTGTCTTTTGTTGGTGTGTT TGTTTTTTTCCAGGGAGGTCTAATTCCGAAGCAGTATTCCAGGTTTTCTCTTTGTTTT ATCAGTGCCAAGATGACCTGTTGTGTCATATAATTTAAGCAGAGCTTAGCATTTATT TTATTCTTTAGAAAACTTAAGTATTTACTTTTTTAAAGCTATTTTTCAAGGAACCTTTT TTTGCAGTATTATTGAATTTATTTTCTAAATCAGGATTGAAACAGGAACTTTTCCAGG TGGTGTTAATAAGCCATTCAAGTGCCTTACACAGCTTTGAAGAAACTAGGACTGCAG TGGGCTCGGATAGGCCCATTGAGGTTTTTAGAAAAGCAGGATTTGTTTTGTTAGGGA GGCATGATTTTGGTGAGATCTTTCTGGAAGAGTTTTCCGCCTCTTTGTGATGCTGAAC ACCCCCAAGGTTCTCCCCTCCCCCCGCTGCCCAGGTGACTGGCAGGAGCTGCGACTG CCACGTAGTGGTGCCTGGGCCCGACAGCGGGGCTCTGGGCATCCCGGGTGACCTTG GCCCATCTGCCTGCATTCCCACCCCCTTGGGCCTGGCTGGATCCCAGGCAGAGGGAC CTTGCTGCTGTGTGATTGGAACATTCCCAAATATCTTGTGAATTTGTAATCAAATTGG TCTCATTGGGAAAGACTCTTAATTAAGAGGCTCAGGCAAGCACAGAGGCAGCCCGT GGGTCTCTGTCTCAGTCTGGAGGCAGCAGGGATGCTGCTGGGAGTCCATGGCACAG GCCACAGCCCCTCACCTTGCCGCGGTGGCTGGCAGCACGCCTGCCTTGCTCTGCCCC ATGCCCTGAACAGGCATGAGAGCTCCACGTCCCCTAGTGCACCCTGAGAGGGGGCT CACAAGTGACCGATCCTGGGTGCCTCAGGGAGCTCACTGAGGGCGTGCAAAGTTGA AAGTGGCAAGGCTGGGGGAGGGTGTCGGGTAGAGGGAAGAGGGCAGGGGGCTAGG GGAGGACTCAGAGGCCATCTGCAGGGCCAAGCCACAGGAAGGGCTGAGCTGGAGG TGGGCAGGGCTGCTCCAGGCAGGTCAGAGCAGTGCAGGGGGAGGAGAGGAGAAAG GGAGGAAGCTGGGCTGTGTGGTCCCCATGAAGGCATTCAGAGTCCACCTGCAGACA GCGAGAGCCCCAGGAAGGTTTGCACAGCTGTGCCCCAAGCACCTTGGCCTCCTCTCA GCTCGCCGAGGAGGCACGCTAGAGCCGCCTTCCCGGTGGGAGCCCTCTGTCCCACA GGGAGCGGGGAGCCAGCTTTGCTGGGGCCCTACCTGCATGCCCAGCCTTACCCCTCA TTCTCACAGCACAGATGAGGTTGAGACCATGCAGTCAATGCATTGCTTAAGGTCTCT TATTTACAAAAAAAAACCTTAAACATAGTCGCTGTCATTCAGACATTCAGAGAATGG TTGGCCACAAACAATGACCAAGTATTGCTTGGCTTAACTTGAAGGCCTGCTGTCTCC TTCTGGGGGTCAGGGACGCAGCTCCACCCTCACCACTAGCCCACCCTGCCCGTGGGC ATAACCTTGACGAAGAGAGAGAATGATTGGCATCTGCTTTTCTCTTTTCTTTGCTAAT AATTCTGTTCCTGGCTGCCGAGAGTGAAGTTTCACCATGTGGAGGTTTGGCTCCTAT CACCTGGTGGTCTGATTCATACCCTAGCCTGAGGCTCCACTGGAAGATCTCGCAGCC TCAGTGTATGGGAAACCCTTTCCCCAGGCTTGTCCCAGCACTGCCGCTCCCCACCCC TGAGCCAGGACCCCAGAGGATGGCCATGCCCCGTGCCTGGCAGAGGTCTGGTGCCA GCACTGGGAGCTGCTCCGCCCTTGCCTTGGGGCCGAGGGAGCCCTCGTCCACCCCTG CACAGCAGCTGGGCACAGAGGAGCGCTCTTCCATCTTGACCAGGACTGCACCAAGA AGCACCAGGTGTCTTCAGCCTCCAACCTCCGGGGCGACCTTCTCTTCCAGCCACAGT CCCATGAGGGCCCCTAGCCAGGGACACTGGTCTGTAAATTGTAATCCTTTCTCCAGC CCAGCTCTCCACTTGTTCCTTGTGTGAGCTGAGCAGGCAGTGCACCTCTGAGTGTCC CTTTTGTAAGGCCCAGGGGTTGCACTGAGTCTGCAGAGGCCGCGACCTCCTAGAACG CTGTGGGTGCAGGTGAGCCGGCGTGTCCTGGGGAGATGCTGCCAGCACACAGGGGC CCTCCTGCTGCCAGCAGGTTGGGGTGGTTAAGTCTTATTAGTGTCTATTCTTAAAATT AAGTGGGCTGGAGAAGAATGGAGCTCCACATGCCAGCACCGTATATGGAATACAAA AGCTGGGGAAGCAGGGCCTGCCTTACAGGTGTGGCTGACTCTGAGCCCAGGCCTGC AGGGGTGGAGGGCAGTCCCTCAGAATCCCAGAGGCAGTCCCAGCCTCAGAACCCAG GATAGGAAATGGGTGTGTTTAGTGGGGAAAGGGACGGGGTGCAGACGGCAGGGCC AGTATGGGGCCCCCTCCCTCTCCTCTCCTCTCCTATGGTGAGCCCAGCGTGGGCACC GGGCCGTCTCAGCCGTGTTCCCAGGGCTGGGAGGACAGCTCTGGCCCTTCTTAGGCC TAGCCTCGTCCCAAGCTAAATGTAAGCCAGTTGGGCTGTGTTAAAGGAAGCAGTGTT TTTGGTTCGATTCTGCCTCTGTAGCTCAAGGGGGGCAGCCCCCAGAGTCCTGTGCAT TCTGCCAAGGCTCCATAGCTTTGCCAAATGCACGGAGCTCTGCCATTCCGGTGCAGT GCAGGCCTTGCGAAGGGTTTATCTGCGTTCGTCTCGGTGGGCTTCTCCTGCATGGGA GTTGTGTTCCTGTGCAAGGGGGAGCTTTGCTCCAGGACAGGATGACTGTCTTCCCTA TTCTTAGGGACAAGTCCCAAGATGCCAGAAAGGCAGTCTCCCAAGGACCCACCATG CAGAAGTGTCAATAAACCACAAGTTCTGAACTCTGTAAAAAAAAAAAAAA PPP2R1A (SEQ ID NO: 19; CR450340.1). ATGGCGGCGGCCGACGGCGACGACTCGCTGTACCCCATCGCGGTGCTCATAGACGA ACTCCGCAATGAGGACGTTCAGCTTCGCCTCAACAGCATCAAGAAGCTGTCCACCAT CGCCTTGGCCCTTGGGGTTGAAAGGACCCGAAGTGAGCTTCTGCCTTTCCTTACAGA TACCATCTATGATGAAGATGAGGTCCTCCTGGCCCTGGCAGAACAGCTGGGAACCTT CACTACCCTGGTGGGAGGCCCAGAGTACGTGCACTGCCTGCTGCCACCGCTGGAGTC GCTGGCCACAGTGGAGGAGACAGTGGTGCGGGACAAGGCAGTGGAGTCCTTACGGG CCATCTCACACGAGCACTCGCCCTCTGACCTGGAGGCGCACTTTGTGCCGCTAGTGA AGCGGCTGGCGGGCGGCGACTGGTTCACCTCCCGCACCTCGGCCTGCGGCCTCTTCT CCGTCTGCTACCCCCGAGTGTCCAGTGCTGTGAAGGCGGAACTTCGACAGTACTTCC GGAACCTGTGCTCAGATGACACCCCCATGGTGCGGCGGGCCGCAGCCTCCAAGCTG GGGGAGTTTGCCAAGGTGCTGGAGCTGGACAACGTCAAGAGTGAGATCATCCCCAT GTTCTCCAACCTGGCCTCTGACGAGCAGGACTCGGTGCGGCTGCTGGCGGTGGAGG CGTGCGTGAACATCGCCCAGCTTCTGCCCCAGGAGGATCTGGAGGCCCTGGTGATGC CCACTCTGCGCCAGGCCGCTGAAGACAAGTCCTGGCGCGTCCGCTACATGGTGGCTG ACAAGTTCACAGAGCTCCAGAAAGCAGTGGGGCCTGAGATCACCAAGACAGACCTG GTCCCTGCCTTCCAGAACCTGATGAAAGACTGTGAGGCCGAGGTGAGGGCCGCAGC CTCCCACAAGGTCAAAGAGTTCTGTGAAAACCTCTCAGCTGACTGTCGGGAGAATGT GATCATGTCCCAGATCTTGCCCTGCATCAAGGAGCTGGTGTCCGATGCCAACCAACA TGTCAAGTCTGCCCTGGCCTCAGTCATCATGGGTCTCTCTCCCATCTTGGGCAAAGA CAACACCATCGAGCACCTCTTGCCCCTCTTCCTGGCTCAGCTGAAGGATGAGTGCCC TGAGGTACGGCTGAACATCATCTCTAACCTGGACTGTGTGAACGAGGTGATTGGCAT CCGGCAGCTGTCCCAGTCCCTGCTCCCTGCCATTGTGGAGCTGGCTGAGGACGCCAA GTGGCGGGTGCGGCTGGCCATCATTGAGTACATGCCCCTCCTGGCTGGACAGCTGGG AGTGGAGTTCTTTGATGAGAAACTTAACTCCTTGTGCATGGCCTGGCTTGTGGATCA TGTATATGCCATCCGCGAGGCAGCCACCAGCAACCTGAAGAAGCTAGTGGAAAAGT TTGGGAAGGAGTGGGCCCATGCCACAATCATCCCCAAGGTCTTGGCCATGTCCGGA GACCCCAACTACCTGCACCGCATGACTACGCTCTTCTGCATCAATGTGCTGTCTGAG GTCTGTGGGCAGGACATCACCACCAAGCACATGCTACCCACGGTTCTGCGCATGGCT GGGGACCCGGTTGCCAATGTCCGCTTCAATGTGGCCAAGTCTCTGCAGAAGATAGG GCCCATCCCGGACAACAGCACCTTGCAGAGTGAAGTCAAGCCCATCCTAGAGAAGC TGACCCAGGACCAGGATGTGGACGTCAAATACTTTGCCCAGGAGGCTCTGACTGTTC TGTCTCTCGCC CFLAR (SEQ ID NO: 20; NM_003879.5). ATACTCAGTCACACAAGCCATAGCAGGAAACAGCGAGCTTGCAGCCTCACCGACGA GTCTCAACTAAAAGGGACTCCCGGAGCTAGGGGTGGGGACTCGGCCTCACACAGTG AGTGCCGGCTATTGGACTTTTGTCCAGTGACAGCTGAGACAACAAGGACCACGGGA GGAGGTGTAGGAGAGAAGCGCCGCGAACAGCGATCGCCCAGCACCAAGTCCGCTTC CAGGCTTTCGGTTTCTTTGCCTCCATCTTGGGTGCGCCTTCCCGGCGTCTAGGGGAGC GAAGGCTGAGGTGGCAGCGGCAGGAGAGTCCGGCCGCGACAGGACGAACTCCCCC ACTGGAAAGGATTCTGAAAGAAATGAAGTCAGCCCTCAGAAATGAAGTTGACTGCC TGCTGGCTTTCTGTTGACTGGCCCGGAGCTGTACTGCAAGACCCTTGTGAGCTTCCCT AGTCTAAGAGTAGGATGTCTGCTGAAGTCATCCATCAGGTTGAAGAAGCACTTGATA CAGATGAGAAGGAGATGCTGCTCTTTTTGTGCCGGGATGTTGCTATAGATGTGGTTC CACCTAATGTCAGGGACCTTCTGGATATTTTACGGGAAAGAGGTAAGCTGTCTGTCG GGGACTTGGCTGAACTGCTCTACAGAGTGAGGCGATTTGACCTGCTCAAACGTATCT TGAAGATGGACAGAAAAGCTGTGGAGACCCACCTGCTCAGGAACCCTCACCTTGTTT CGGACTATAGAGTGCTGATGGCAGAGATTGGTGAGGATTTGGATAAATCTGATGTGT CCTCATTAATTTTCCTCATGAAGGATTACATGGGCCGAGGCAAGATAAGCAAGGAG AAGAGTTTCTTGGACCTTGTGGTTGAGTTGGAGAAACTAAATCTGGTTGCCCCAGAT CAACTGGATTTATTAGAAAAATGCCTAAAGAACATCCACAGAATAGACCTGAAGAC AAAAATCCAGAAGTACAAGCAGTCTGTTCAAGGAGCAGGGACAAGTTACAGGAATG TTCTCCAAGCAGCAATCCAAAAGAGTCTCAAGGATCCTTCAAATAACTTCAGGCTCC ATAATGGGAGAAGTAAAGAACAAAGACTTAAGGAACAGCTTGGCGCTCAACAAGA

ACCAGTGAAGAAATCCATTCAGGAATCAGAAGCTTTTTTGCCTCAGAGCATACCTGA AGAGAGATACAAGATGAAGAGCAAGCCCCTAGGAATCTGCCTGATAATCGATTGCA TTGGCAATGAGACAGAGCTTCTTCGAGACACCTTCACTTCCCTGGGCTATGAAGTCC AGAAATTCTTGCATCTCAGTATGCATGGTATATCCCAGATTCTTGGCCAATTTGCCTG TATGCCCGAGCACCGAGACTACGACAGCTTTGTGTGTGTCCTGGTGAGCCGAGGAG GCTCCCAGAGTGTGTATGGTGTGGATCAGACTCACTCAGGGCTCCCCCTGCATCACA TCAGGAGGATGTTCATGGGAGATTCATGCCCTTATCTAGCAGGGAAGCCAAAGATG TTTTTTATTCAGAACTATGTGGTGTCAGAGGGCCAGCTGGAGGACAGCAGCCTCTTG GAGGTGGATGGGCCAGCGATGAAGAATGTGGAATTCAAGGCTCAGAAGCGAGGGCT GTGCACAGTTCACCGAGAAGCTGACTTCTTCTGGAGCCTGTGTACTGCGGACATGTC CCTGCTGGAGCAGTCTCACAGCTCACCATCCCTGTACCTGCAGTGCCTCTCCCAGAA ACTGAGACAAGAAAGAAAACGCCCACTCCTGGATCTTCACATTGAACTCAATGGCT ACATGTATGATTGGAACAGCAGAGTTTCTGCCAAGGAGAAATATTATGTCTGGCTGC AGCACACTCTGAGAAAGAAACTTATCCTCTCCTACACATAAGAAACCAAAAGGCTG GGCGTAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGAGGGCAGAT CACTTCAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTAAACGCTGTCCCTA GTAAAAATACAAAAATTAGCTGGGTGTGGGTGTGGGTACCTGTATTCCCAGTTACTT GGGAGGCTGAGGTGGGAGGATCTTTTGAACCCAGGAGTTCAGGGTCATAGCATGCT GTGATTGTGCCTACGAATAGCCACTGCATACCAACCTGGGCAATATAGCAAGATCCC ATCTCTTTAAAAAAAAAAAAAAAGGACAGGAACTATCTTACTCAATGTATTAGTCAT GTTTCTCTAGAGGGACAGAACTAATAGGATACATGTATATAAAAAGGGGAGTTTATT AAGGAGTATTGACTCACATGATCACAGGGTTAGGTCCCACAATAGGTCATCTGCAA GCAAGGAAGCCAATTCAAGTCCCAAAGCTGAAGAACTTGGAGTCCAATGTTTGAGG GCAGGAAGCATTCAGCATGAGAGAAAGATGGAGGCCAGAAGACTACACCAGTCTA GTCTTTCCATGTTTTGCCTGCTTTTATTCTGGCAGTGCTGGCAGCTGATTAGATGGTG CCCACCCAGATTGAGGATGGTCTGCCTTTCCCAGTCCACTGACTCAAATGTTAAATC TCCTTTGGCAGCACCCTCACAGATGTACCCGGGAACACTTTGCATCCTTCTATTCAAT CAAGTTGATACTCAGTATTAACCATCACAGTCCATTTGGGCAACTATACCAAATTAC CATAGACCAGGTGACTTAAACAGCAGTTATTTCTCACAGTTCCGGAGGCTGGGAAAT CCAACATCTAAGTGGTAGCATATCTGGTGTCTGGTAAGGCATGCTTCCAGATCTTAC CAGATGTCAGTCTTTTGATGTTCTCACATGGCAGAAAAAGAGGATGCAAACTCTCAA GTATATCTTTAAGGGCACAAATTCCATTCATGAGGGCTCTACCCTCATCACCTAATT ACCTCCCAAAGGCCCCACCTTCTGATACTGTCACTTTGGGGATACTGTCTCCCCTTTG AATTCTGGGGGGAATACAAACATTCAGTTTGTAACAATAGCCTTATGATTTAGAGGT TACTTGTTCATTCACCTAGACCTCAAATTGCATTTTACAGCTAGTCAAGTATATCTTT CTCTGATTTGATAGTGTGACCTAAAAGGGGACCATTGTTTGAAATATCATTAGAGTT GCTTATTATTATTATTATTATTATTATTATTATTATTATTATTATTATTGAGACAGAGT TTCATTCTGCTGCCCAGGCTGGAGTGCAGTGGCATCATCTTGGCTCATTGCAACCTCT GCCTTCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAG GCTCCTGCCACCACACCCGGCTAATTTTTGTATTTTTAGTGGAGACAGGGTTTCCACC ATGTTGGCCAGCGTGGTCTTGAACTCCTGACCTCAGGTGATTCACCAGCCTCGGCCT CCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCTGGCCTATTATTATTTTTA AATTTTTTTTTTTTAATTGATCATTCTTGGGTGTTTCTCACAGAGGGTGATTTGGCAG GGTCACAGGACAATAGTGGAGGGAAGGTCAGCAGATAAACAAGTGAACAAAGGTC TCTGGTTTTCCTAGGCAGAGGACCCTGCGGCCTTCCGCAGTGTTTGTGTCCCTGGGTA CTTGAGATTAGGGAGTGGTGATGACTCTTAAGGAGCATGCTGCCTTCAAGCATCTGT TTAACAAAGCACATCTTGCACTGCCCTTAATCCATTTAACCCTGAGTGGACACAGCA CATGTTTCAGAGAGCACAGGGTTGGGGGTAAGGTCATAGATCAACAGCATCCTAAG GCAGAAGAATTTTTCTTAGTACAGAACAAAATGAAGTCTCCCATGTCTACTTCTTTCT ACACAGACACAGCAACAATCTGATTTCTCTATCTTTTCCCCACCTTTCCCCCTTTTCT ATTCCACAAAACCGCCATCGTCATCATGGCCTGTTCTCAATGAGCTGTTGGGTACAC CTCCCAGACGGGGTGGCGGCTGGGCAGAGGGGCTCCTCACTTCCCAGATGGGGCGG CCAGGCGGACGCGCCCCCCACCTCCCTCCCGGACGGGATAGCTGGCCGGGCGGGGG CTGACCCCCCACCTCCCTCCCCGACGGGGCGGCTGGCCGGGCGGGGGCTGACCCCC ACGCCTCCCTCCCGGACGGGGCGGCTGCCAGGCGGAGGGGCTCCTCACTTCTCAGA CGGGGTGGCTGCTGGGCGGAGACGCTCCTCACTTCCCAGACAGGGTGGCTGTCGGG CGGAGGGGCTCCTCACTTCTCAGACGGGGCAGCTGCGGGCGGAGGGGCTCCTCACT TCTCAGACGGGGTGGCCGGGCAGAGAAGCTCCTCACATCCCAGACGGGGGGGCGGG GCAGAGGCGCTCCCCACATCTCAGACGATGGGCGGCCGGGCAGAGACGCTCCTCAC TTCATCCCAGACGGGGTGGCGGCCGGGCAGAAGCTGTAATCTCGGCACCCTGGGGG GCCAAGGCAGGCGGCTGGGAGGCGGAGGCCGTAGCCAGCTGAGATCACACCACTGC ACTCCAGCCTGGGCAACATTGAGCACTGAGTGGACGAGACTCTGCCCGCAATCCCG GCACCTCGGGAGGCCGAGGCTGGCAGATCACTCGCAGTCAGGAGCTGGAGACCAGC CCGGCCAACACAGTGAAACCCTGTCTCCACCAAAAAAATACGAAAACCAGTCAGGC GTGGCGGCGCCCGCAATGGCAGGCACGCGGCAGGCCGAGGCGGGAGAATCAGGCA GGGAGGCTGCAGTGAGCCGAGATGGCAGCAGTACAGTCCAGCTTCGGCTCGGCATC AGAGGGAGACCGTGGGGAGAGGGAGAAGAGAGGGAGGGGGAGAGGGCTATTTTTA AAATTTTTTAAAATTGCTGAACAGGGGTACCTCTGGGCAGTGTGTCAGAATACCACT TTTTAAATATTTTATGATTTATTTATTTTTCTATTTCTTGAGGTTTTAACTGATGTGTA TCTGTATGTCTATTTGTGTATATTTTGTCATGATCATGTAACAGAGTCTGAAAAGTGT CGAAGAGACAGTTTTCAGGAACAACAAGCAATTATTCCTACTTTCCAAGTTATTTTG ATGCCATGGTGGCTCATACCTATAATCTGAGTACTTTGGGAGGCTGAGGTGGACTGA TCACTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGCAAGACTCCATCTCT ACAAAAAAAGACAAAATTTAGCTGAGCGTGGTGGCGTGTTCCTGTAGTCCCAGCTA CTTGGGAGGCTGAAGTGAGTGGATCCCCTGAGCCCAGAGAGGTCAAGGTTGTGATG AGCTGTGATCACACCACTGCACTTCAGCATGGGAGACAGAGTGAGACCCTGTTTCAG AAAAAATAAATAAATAAAACCACCAGCACCACAAACAACAACAAAAAGTTATTTTG TACTTGTTTTGAGCACAGGACTCCTGAGGGTATCTTTGCATTTAATATTACATAGGG GTGCCAGTGGGAAGTAATGTGTATGCTTGGCCTCATGAGCTAAAACCCTGTGTTAAT TATGACAGAAGGAAAGTGTGTGAGAGAGATCTTAACTACCTAGCAGCTCTAGCTGC CATCTTGAACCATGAAGATACGGGCCACACGTAGGGGTAGCTGGGTAGTGAGCAGC AAGAAGCCTTGTTGGATGAGGGCACGAAGGAGCAGAATCACTGGAATCACTGTGTC AGCCCTAATTACCTACCTCTGGACTTTTATGTGAGGGGAAAAAAAATTGACAGTTTA TATTTATCTCAACCTAGTTAACCCAAGTGATGCATTGTTATGAGATTAAAATGTTTGG AGGCCGGGTGCGGTGGCTCACGCCTATAATCCCAGCCCTTTGGGAGGCCAAGGCGG GCGGATCACGAGGTCAGGAGATCAAGACCATCCTGGCTAACATGTAAAACCCCGTC TCTACTAAAAATACAAAAAATTAGCCAGGCGTTGTGGCGGTCGCCTGTAGTCCCTGC TATTTGGGAGGCCGAGGCAAGAGAACGGCATGAACCTGGGAGGTGGAGCTTGCAGC GAGCTGAGATCTTGCCACTGCACTCCAGCCTGGGCGACAGTGCGAGACTCTGTCTCA AAAATAAATAAATAAATAAATAATAAATAAAATGTTTGGAATGTTGGCTTCATCCCT GGGATGCAAGGCTGGTTCAACATACGCAAATCAAGAAACATAATTCATCACATAAA CAGAACTAAAGACAAAAACCACATGATTATCTCAATAGATACAGAAAAGGCCTTCA ATAAAATTCAACGTTGCTTCATGTTAAAAACTCTCAATAAACTAGGTATTGATGGAA AATATCTCAAAATAATAACCATTTATGACAAACCCACAGCCATTATCATACTGAATG GGCAAAAGCTGGAAGCATTCCCCTTGAAAACTGGCACAAGACAGGGATGCCGTCTC ACCACTCCTATTTAACATAGTATTGGAAGTTCTGGCCAAGAAAATCAGGCAAGAGA AACAAATAAGGGGTATTCAAATAGGAAAAGAGGAAGTAAAACTGTGTTTGCAGATG ACATGATACTATATCTAGAAAACCCCATTATCTCCACCCAAAAGTTCCTTAAGCTGA TAAGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTGCAGAAATCACAAGCA TTCTATACACCAACAATACACAAGCAGAGAGCCAAATCATGAATGAACTCCCATTC ACAGTTGCTAGAAAGAGAATAAAATACCTAGGAATACAGCTAATAAGATGTGAAGG ATCTCTTCAAGGAGAACTACAAACCACTGCTCAAGGAAATAAGAGAGGACACAAAT GAAAAAACATTCCATTCTCGTGGATAGGAAGAATCAATATCATGAAAATGGCCATA CTACCCAAAGTAATTTATAGGTTCATTGCTATTCCCATTAAACTACTATTGACATTCT TCACAGAATTAGAAAAAAACTACTTTAAAATTCAAATGGAACCAAAAAAGAGCCCG TATAACCAAGACAACAATAAGCAAAAAGAACAAAGCTGGAAGCATCACACTACCC AACTTCAAAGTATACTGCAAGGCTACAGTAGCCAAAATGGCATGGTACTGGTACAA AAACAGACACATAGACCAATGGAACAGAATAGAGACCAGAGAAAGAAGACCACAC ATCTACAGCCATCTGATCATCGACAAACCTGACAAAAACAAGCAATGGGGAAAAGA TTCCCTATTTAATAAATGGTGCTGGGAAAACTGGCTAGCCATATGCAGAAAATTGAA ACTGACCCCTTCCTTACACCTTATACAAAAATTAACTCAAGATTAAAGACTTAATGT AAAACCTAAAACTATAAAAACCCTAGAAGAAAATCTATTTAATACCATTCAAGACA TAGGCACAAGCAAAGGTTTCATGACAAAAACATCAAAAGCAATTGCAACAAAAGCA AAAATTACAAATGGGATCTAATTAAACTAAAGAGCTCCTGCACAGCAAAAGAAACT ATCATTAGAGTGAACAGGCAACCTACAGAATGGGAGAACATTTTTGCAATCTATCCA TCTGACAAAGGTCTAATATCCAGAACCTACAAGGAACTTAAAACAAATTTACAAGG AAAAAAACAACCCCATCAAAAAGTGGACAAAGGACATGAACAGACACTTCTCAAA AGAAGACATTTATGTGGCCAACAAACATATAAAAAAAAGCTCAACCTTACTGATCA TTAGAGAAATGCAAAGGAGAACCACAATGAGATACCATCTCATGCCGGTCAGAATG GTGATTATTAAAAAGTCAAAAAACAACAGATGCTGGCGAGGCTGTGGAGAAGTAGG AACACTTTTACATTGTTGGTGGGAATGTAAATTAGTTCAACCGTTGTGGAAGTGTGT GTGGCTATTCCTCAAAGATCTAGAACTAGAAATACTATTTGTCCCAGCAATCCCATT ACTGGGTATATACCCAAAGGAATATAAACCATTTTATTATAAAGATACATGCACATT TTTGTTCATTGCAGCACTCTTCACAATAGCAAAGACACAATAGCAAATGCCCATCAA AGATAGACTGGATAAAGAAAATGTGGTACATATACACCATGGAATACTGTGCAGTG

CAGCCATTACAGCTTTTGGTGATACAGTGAATCAGATTTTTCATTAATTCTTTTAATT GGTTATTACTGAACGTGAAAAAGTAATGTTTGTATTGAAATCTTGAGTCTGGCCATG TTTCTATTTTAAATTCATAAAGAATTCTAACAAGAGGAATTCCAAGAATGTCATAAA TGGATGTTTCTCCATGGATGAAGGAACTGTTTTATTCACTTGCTGATAATTCAGCCTA ATCCAGTTTGACATCATATAGATAAGTAGTTGAATTATGGATTTAAAATACATATCA TTTTCTAACTCCAAAGGTAATACTTATTTAAATGGTTTTGAAAATATAGAAAGGCAC AATTTCTTTTTAAATCTGTTATTCTCCACCACCACTCAATCTGTCTATCATCTATCTCT CCATTCATTCTTCCATTTGTTTATATCTGTTAATCTTTGTATGTGTTCATGTATAGCTT TTACATGATTGGAATCATAATGCATATTCCATTTTGAAGTCTGCTTTTTTTTACACAA AAATATGTTGTGAATATTTTCCTATATTATGAAATATCATTAGCTGAGCTTTTAGAAT TGACTGCATGTTTTGGTACCATTTAGATATAGTTTAAGATACTTAGAAGTTATGTGGC TTTGCCACTATGGATGAATCTTATTTACTCAATATTAATTACTTACAAATAACCTCAC CTAAACACTACTCAGCCATAAAAAGGAATGAATTAATGACATTCACAGCAACCTGG AGACTATTACTCTAAAGGAAGTAACTGAGGAATGGAAAACCAAACATTGTATGTTC TCACTCATAAGTGGGAGATAAGCTATGAGGATGCAAAGGCATAAGAAGGATACAAT GGACTTTGGGGACTTAGGGGAAAGGGTGGGAGGGGGGTGAAGGATAAAAGAATAC AAATTGGGTTCAGTGTATACTGCTCAGGTGATGGGTGCACCAGAATCTCACAAGTAA CCACTTAATTACTTACGCATGTAACCAGATACCACCTGTTCCCCAAACACCTATGGA AATAATTTTGTTTTTTTTTTTAAAAAAGGAATGAGATCATGTCCTTTGCAGGGACATG GATGAAGCTGGAAGCCATTATCCTCAGCAAACTAACAGAGGAGCAGGAAACCAAAC ACCACATGTTCTCACTTGTAAGCGGAAGCTGAACAATGAGAACACACGGACACAGG GATGAGATCAACACACACTGGGGCCTGATGCAGGGGCCGTAGCGGGGAGAGCATCA GGATAACTAGCTAATGCATGTGGGGCTTAATACCTAGGTGATAGGTTGATAGGTGCA GCAAACCACCATGGGACACGTTTACCTATGTAACAAACCCGCACATCCTGCACTTGT ATCCAGAACTTAAAATATTTTAAAAATCTTTAGAGAATACAAAAAAAAAAAAAAAG ATTCTTCAATGCATACACAATAAAATTGCAGTTCAGTCAAACATTGGAAGTCTTTCT CTGACTGTCTAGTTGGTATCTTCATTTTCAGCTTCTTCAAGATCCCACTCCAAACACT GTTAGCTCAGCCAAATTGAACAGCTCATATCTCCTACCTCTGGATCTTTGGTTCTGGT GATTGTATATTTCTGGACCATCTGGAACCCCAGCATATCACCCTACCCCACATCTCC ACATCCCCAAAATATAACCATACTTCAAGGGCAGTTCAAATACCATCTCCTTCTATC CTCCATGAAGTCAGTTATCTCTTCCATTGGAATTATCGCCCCCTCTCCTGAACAGTAC TATTTCGTGTGAATCTCCTCCAAGCCTTCTTTTCATTTTATATCTCATGCTGTAATTCT TGGAAAGTATGCTGTAGCTCAAGTGCAGAATTCTCATCAGTTTTATCTTTATATCTCT CCTAAACACTTTACCTGATGAAGAGCCTGGCATACACATAAATATATATTGAATGAA TCAGTGATGGATTGAAAAGAGAAATGATGGATCTCCTAAATTTTAACTTTTATAAAA TATTTTGATACATTCATGACCTTACTTTAGCAAGCAATGAACGTGATGTAAACTATT GTTGATATAGTTTTTATATTGGAAGTGTAAGTAGTTTGTGGCATGGGATTGTGACAT ATCCTAGGTTTCCTCATCTTCTTTTTATTGAAATGTAATTCACAAGCCATAAAATTTG CCCCTTTAAAGTAAATGATGCAGTGGATTTTAGTATATTTACAGAGTTGTGCAATCA TCACCACTATCTAATTCCAGAACATTTCCATCTACCTAGAAACTCCATACCAGTGAG CTGCCACTCTAATCCTCCTCTTCCCCCAGCCTCTAGAAACAATAATCCATTTTCTGTC TCTATGATTTGCCTGTTCTAGATATTTTATAAAAATAAACATGTGGCCTTTCGTGTCT GACTTCCTTCACTTAAAAAAAAAAAAAAAAAA DHRS13 (SEQ ID NO: 21; NM_144683.3). CGCCTCCGCCTTCGGAGGCTGACGCGCCCGGGCGCCGTTCCAGGCCTGTGCAGGGC GGATCGGCAGCCGCCTGGCGGCGATCCAGGGCGGTGCGGGGCCTGGGCGGGAGCCG GGAGGCGCGGCCGGCATGGAGGCGCTGCTGCTGGGCGCGGGGTTGCTGCTGGGCGC TTACGTGCTTGTCTACTACAACCTGGTGAAGGCCCCGCCGTGCGGCGGCATGGGCAA CCTGCGGGGCCGCACGGCCGTGGTCACGGGCGCCAACAGCGGCATCGGAAAGATGA CGGCGCTGGAGCTGGCGCGCCGGGGAGCGCGCGTGGTGCTGGCCTGCCGCAGCCAG GAGCGCGGGGAGGCGGCTGCCTTCGACCTCCGCCAGGAGAGTGGGAACAATGAGGT CATCTTCATGGCCTTGGACTTGGCCAGTCTGGCCTCGGTGCGGGCCTTTGCCACTGC CTTTCTGAGCTCTGAGCCACGGTTGGACATCCTCATCCACAATGCCGGTATCAGTTC CTGTGGCCGGACCCGTGAGGCGTTTAACCTGCTGCTTCGGGTGAACCATATCGGTCC CTTTCTGCTGACACATCTGCTGCTGCCTTGCCTGAAGGCATGTGCCCCTAGCCGCGT GGTGGTGGTAGCCTCAGCTGCCCACTGTCGGGGACGTCTTGACTTCAAACGCCTGGA CCGCCCAGTGGTGGGCTGGCGGCAGGAGCTGCGGGCATATGCTGACACTAAGCTGG CTAATGTACTGTTTGCCCGGGAGCTCGCCAACCAGCTTGAGGCCACTGGCGTCACCT GCTATGCAGCCCACCCAGGGCCTGTGAACTCGGAGCTGTTCCTGCGCCATGTTCCTG GATGGCTGCGCCCACTTTTGCGCCCATTGGCTTGGCTGGTGCTCCGGGCACCAAGAG GGGGTGCCCAGACACCCCTGTATTGTGCTCTACAAGAGGGCATCGAGCCCCTCAGTG GGAGATATTTTGCCAACTGCCATGTGGAAGAGGTGCCTCCAGCTGCCCGAGACGAC CGGGCAGCCCATCGGCTATGGGAGGCCAGCAAGAGGCTGGCAGGGCTTGGGCCTGG GGAGGATGCTGAACCCGATGAAGACCCCCAGTCTGAGGACTCAGAGGCCCCATCTT CTCTAAGCACCCCCCACCCTGAGGAGCCCACAGTTTCTCAACCTTACCCCAGCCCTC AGAGCTCACCAGATTTGTCTAAGATGACGCACCGAATTCAGGCTAAAGTTGAGCCTG AGATCCAGCTCTCCTAACCCTCAGGCCAGGATGCTTGCCATGGCACTTCATGGTCCT TGAAAACCTCGGATGTGTGCGAGGCCATGCCCTGGACACTGACGGGTTTGTGATCTT GACCTCCGTGGTTACTTTCTGGGGCCCCAAGCTGTGCCCTGGACATCTCTTTTCCTGG TTGAAGGAATAATGGGTGATTATTTCTTCCTGAGAGTGACAGTAACCCCAGATGGAG AGATAGGGGTATGCTAGACACTGTGCTTCTCGGAAATTTGGATGTAGTATTTTCAGG CCCCACCCTTATTGATTCTGATCAGCTCTGGAGCAGAGGCAGGGAGTTTGCAATGTG ATGCACTGCCAACATTGAGAATTAGTGAACTGATCCCTTTGCAACCGTCTAGCTAGG TAGTTAAATTACCCCCATGTTAATGAAGCGGAATTAGGCTCCCGAGCTAAGGGACTC GCCTAGGGTCTCACAGTGAGTAGGAGGAGGGCCTGGGATCTGAACCCAAGGGTCTG AGGCCAGGGCCGACTGCCGTAAGATGGGTGCTGAGAAGTGAGTCAGGGCAGGGCA GCTGGTATCGAGGTGCCCCATGGGAGTAAGGGGACGCCTTCCGGGCGGATGCAGGG CTGGGGTCATCTGTATCTGAAGCCCCTCGGAATAAAGCGCGTTGACCGCCGAAAAA AAAAAAAAAAAAAAA ACAA1 (SEQ ID NO: 22; NM_001607.3). GGGTTCCCAGGCCGACTCTCCTTGTGGTTGGCTGAGGCTGGAGGTGGACGGGACTTT TGGAGGGTCGCTCGCGTCTGTTCGCAGAGCTGTGGGCGGAGTTGAGGCCTTGGAGG CTGAGATGTGGTTCTGCGCGTGTGCGGACGGCTGTCTGTTAACTCCGCGGTCAGTTC CCGGACTGGTGGCTGGTCTGCAGGGTTGACCTGCGCAATGCAGAGGCTGCAGGTAG TGCTGGGCCACCTGAGGGGTCCGGCCGATTCCGGCTGGATGCCGCAGGCCGCGCCTT GCCTGAGCGGTGCCCCGCAGGCCTCGGCCGCGGACGTGGTGGTGGTGCACGGGCGG CGCACGGCCATCTGCCGGGCGGGCCGCGGCGGCTTCAAGGACACCACCCCCGACGA GCTTCTCTCGGCAGTCATGACCGCGGTTCTCAAGGACGTGAATCTGAGGCCGGAACA GCTGGGGGACATCTGTGTCGGAAATGTGCTGCAGCCTGGGGCCGGGGCAATCATGG CCCGAATCGCCCAGTTTCTGAGTGACATCCCGGAGACTGTGCCTTTGTCCACTGTCA ATAGACAGTGTTCGTCGGGGCTACAGGCAGTGGCCAGCATAGCAGGTGGCATCAGA AATGGGTCTTATGACATTGGCATGGCCTGTGGGGTGGAGTCCATGTCCCTGGCTGAC AGAGGGAACCCTGGAAATATTACTTCGCGCTTGATGGAGAAGGAGAAGGCCAGAGA TTGCCTGATTCCTATGGGGATAACCTCTGAGAATGTGGCTGAGCGGTTTGGCATTTC ACGGGAGAAGCAGGATACCTTTGCCCTGGCTTCCCAGCAGAAGGCAGCAAGAGCCC AGAGCAAGGGCTGTTTCCAAGCTGAGATTGTGCCTGTGACCACCACGGTCCATGATG ACAAGGGCACCAAGAGGAGCATCACTGTGACCCAGGATGAGGGTATCCGCCCCAGC ACCACCATGGAGGGCCTGGCCAAACTGAAGCCTGCCTTCAAGAAAGATGGTTCTAC CACAGCTGGAAACTCTAGCCAGGTGAGTGATGGGGCAGCTGCCATCCTGCTGGCCC GGAGGTCCAAGGCAGAAGAGTTGGGCCTTCCCATCCTTGGGGTCCTGAGGTCTTATG CAGTGGTTGGGGTCCCACCTGACATCATGGGCATTGGACCTGCCTATGCCATCCCAG TAGCTTTGCAAAAAGCAGGGCTGACAGTGAGTGACGTGGACATCTTCGAGATCAAT GAGGCCTTTGCAAGCCAGGCTGCCTACTGTGTGGAGAAGCTACGACTCCCCCCTGAG AAGGTGAACCCCCTGGGGGGTGCAGTGGCCTTAGGGCACCCACTGGGCTGCACTGG GGCACGACAGGTCATCACGCTGCTCAATGAGCTGAAGCGCCGTGGGAAGAGGGCAT ACGGAGTGGTGTCCATGTGCATCGGGACTGGAATGGGAGCCGCTGCCGTCTTTGAAT ACCCTGGGAACTGAGTGAGGTCCCAGGCTGGAGGCGCTACGCAGACAGTCCTGCTG CTCTAGCAGCAAGGCAGTAACACCACAAAAGCAAAACCACATGGGAAAACTCAGC ACTGGTGGTGGTGGCAGTGGACAGATCAAGGCACTTCAACTCATTTGGAAAATGTG AACACTGATGACATGGTATAGGAGTGGGTGGGGTGTTGAGCCACCCATCAGACCCT CTTTAGCTGTGCAAGATAAAAGCAGCCTGGGTCACCCAGGCCACAAGGCCATGGTT AATTCTTAAGGCAAGGCAAATCCATGGATGAGAAGTGCAATGGGCATAGTAAAAGT GCATGAATTTATCTTAAAAAAAAAAAAAAAAAAAAAA INPP5J (SEQ ID NO: 23; NM_001284285.1). CAGGTTGAAATGGCTGATGACATCACTGGTTCCCGGGAGCGGTAGAGCTGGAGCCG GAGCCAAGGGAGTCCAGGCTGCCGGGGGCTGCAGACATGGAGGGCCAGAGCAGCA GGGGCAGCAGGAGGCCAGGGACCCGGGCTGGCCTGGGTTCCCTGCCCATGCCCCAG GGTGTTGCCCAAACTGGGGCACCCTCCAAGGTGGACTCAAGTTTTCAGCTCCCAGCA AAGAAGAACGCAGCCCTAGGACCCTCGGAACCAAGGTTGGCTCTGGCACCTGTAGG GCCACGGGCAGCTATGTCAGCTTCCTCGGAAGGACCGAGGCTGGCTCTGGCATCTCC CCGACCAATCCTGGCTCCACTGTGTACCCCTGAAGGGCAGAAAACAGCTACTGCCC ACCGCAGCTCCAGCCTGGCCCCAACATCTGTGGGCCAGCTGGTGATGTCTGCCTCAG CTGGACCAAAGCCTCCCCCAGCGACCACAGGCTCAGTTCTGGCTCCGACGTCCCTGG GGCTGGTGATGCCTGCCTCAGCAGGGCCAAGATCTCCCCCAGTCACCCTGGGGCCCA ATCTGGCCCCAACCTCCAGAGACCAGAAGCAGGAGCCACCTGCCTCCGTGGGACCC AAGCCAACACTGGCAGCCTCTGGCCTGAGCCTGGCCCTGGCTTCTGAGGAGCAGCC CCCAGAACTCCCCTCCACCCCTTCCCCGGTGCCCAGTCCAGTTCTGTCTCCAACTCAG

GAACAGGCCCTGGCTCCAGCATCCACGGCATCAGGCGCAGCCTCTGTGGGACAGAC ATCAGCTAGAAAGAGGGATGCCCCAGCCCCTAGACCTCTCCCTGCTTCTGAGGGGC ATCTCCAGCCTCCAGCTCAGACATCTGGTCCTACAGGCTCCCCACCCTGCATCCAAA CCTCCCCAGACCCTCGGCTCTCCCCCTCCTTCCGAGCCCGGCCTGAGGCCCTCCACA GCAGCCCTGAGGATCCTGTTTTGCCACGGCCACCCCAGACCTTGCCCTTGGATGTGG GCCAGGGTCCTTCAGAGCCTGGCACTCACTCCCCTGGACTTCTGTCCCCCACCTTCC GGCCTGGGGCCCCCTCAGGCCAGACTGTGCCCCCACCTCTGCCCAAGCCACCCCGAT CACCCAGCCGTTCCCCAAGCCACTCCCCGAATCGCTCTCCCTGTGTTCCCCCAGCCC CTGACATGGCCCTCCCAAGGCTTGGCACACAGAGTACAGGGCCTGGCAGGTGCCTG AGCCCCAACCTTCAGGCCCAAGAAGCCCCAGCCCCAGTCACCACCTCCTCTTCTACA TCCACCCTGTCATCCTCCCCTTGGTCAGCTCAGCCTACCTGGAAGAGCGACCCCGGC TTCCGGATCACTGTGGTCACATGGAACGTGGGCACTGCCATGCCCCCAGACGATGTC ACATCCCTCCTCCACCTGGGCGGTGGTGACGACAGCGACGGCGCAGACATGATCGC CATAGGGTTGCAGGAAGTGAACTCCATGCTCAACAAGCGACTCAAGGACGCCCTCT TCACGGACCAGTGGAGTGAGCTGTTCATGGATGCGCTAGGGCCCTTCAACTTCGTGC TGGTGAGTTCGGTGAGGATGCAGGGTGTCATCCTGCTGCTGTTCGCCAAGTACTACC ACCTGCCCTTCCTGCGAGACGTGCAGACCGACTGCACGCGCACTGGCCTGGGCGGCT ACTGGGGTAACAAGGGTGGCGTGAGCGTGCGCCTGGCGGCCTTCGGGCACATGCTC TGCTTCCTGAACTGCCACTTGCCTGCGCATATGGACAAGGCGGAGCAGCGCAAAGA CAACTTCCAGACCATCCTCAGCCTCCAGCAGTTCCAAGGGCCGGGCGCACAGGGCA TCCTGGATCATGACCTCGTGTTCTGGTTCGGGGACCTGAACTTCCGCATTGAGAGCT ATGACCTGCACTTTGTCAAGTTTGCCATCGACAGTGACCAGCTCCATCAGCTCTGGG AGAAGGACCAGCTCAACATGGCCAAGAACACCTGGCCCATTCTGAAGGGCTTTCAG GAGGGGCCCCTCAACTTCGCTCCCACCTTCAAGTTTGATGTGGGTACCAACAAATAC GATACCAGTGCCAAGAAACGGAAGCCAGCTTGGACAGACCGTATCCTATGGAAGGT CAAGGCTCCAGGTGGGGGTCCCAGCCCCTCAGGACGGAAGAGCCACCGACTCCAGG TGACGCAGCACAGCTACCGCAGCCACATGGAATACACAGTCAGCGACCACAAGCCT GTGGCTGCCCAGTTCCTCCTGCAGTTTGCCTTCAGGGACGACATGCCACTGGTGCGG CTGGAGGTGGCAGATGAGTGGGTGCGGCCCGAGCAGGCGGTGGTGAGGTACCGCAT GGAAACAGTGTTCGCCCGCAGCTCCTGGGACTGGATCGGCTTATACCGGGTGGGTTT CCGCCATTGCAAGGACTATGTGGCTTATGTCTGGGCCAAACATGAAGATGTGGATGG GAATACCTACCAGGTAACATTCAGTGAGGAATCACTGCCCAAGGGCCATGGAGACT TCATCCTGGGCTACTATAGTCACAACCACAGCATCCTCATCGGCATCACTGAACCCT TCCAGATCTCGCTGCCTTCCTCGGAGTTGGCCAGCAGCAGCACAGACAGCTCAGGCA CCAGCTCAGAGGGAGAGGATGACAGCACACTGGAGCTCCTTGCACCCAAGTCCCGC AGCCCCAGTCCTGGCAAGTCCAAGCGACACCGCAGCCGCAGCCCGGGACTGGCCAG GTTCCCTGGGCTTGCCCTACGGCCCTCATCCCGTGAACGCCGTGGTGCCAGCCGTAG CCCCTCACCCCAGAGCCGCCGCCTGTCCCGAGTGGCTCCTGACAGGAGCAGTAATG GCAGCAGCCGGGGCAGTAGTGAAGAGGGGCCCTCTGGGTTGCCTGGCCCCTGGGCC TTCCCACCAGCTGTGCCTCGAAGCCTGGGCCTGTTGCCCGCCTTGCGCCTAGAGACT GTAGACCCTGGTGGTGGTGGCTCCTGGGGACCTGATCGGGAGGCCCTGGCGCCCAA CAGCCTGTCTCCTAGTCCCCAGGGCCATCGGGGGCTGGAGGAAGGGGGCCTGGGGC CCTGAGGGTGGGGTAGGCAGATGGGCCAAGGTGACCACCATTCTGCCTCAATCTTTT GCAAGCCCACCTGCCTCTCTCCTGCTGCTCCTCCAGCTGTATCTGCACCTGCCTCTCT GTCCTGGCCAGGGGTGGACAACTGGGGTCCCCCAAAACTCAGTCCTGGCACCTCAA CTGTGACAATCAGCAAAGCCCCACCCAGGCCCCCATCTGGGATGATGGGAGAGCTC TGGCAGATGTCCCAATCCTGGAGGTCATCCATTAGGAATTAAATTCTCCAGCCTCAA AAAAAAAAAAAAAAA OAZ1 (SEQ ID NO: 24; NM_004152.2). TTTTGCGAACGGCGAGCAGCGGCGGCGGCGCGGAGAGACGCAGCGGAGGTTTTCCT GGTTTCGGACCCCAGCGGCCGGATGGTGAAATCCTCCCTGCAGCGGATCCTCAATAG CCACTGCTTCGCCAGAGAGAAGGAAGGGGATAAACCCAGCGCCACCATCCACGCCA GCCGCACCATGCCGCTCCTAAGCCTGCACAGCCGCGGCGGCAGCAGCAGTGAGAGT TCCAGGGTCTCCCTCCACTGCTGTAGTAACCCGGGTCCGGGGCCTCGGTGGTGCTCC TGATGCCCCTCACCCACCCCTGAAGATCCCAGGTGGGCGAGGGAATAGTCAGAGGG ATCACAATCTTTCAGCTAACTTATTCTACTCCGATGATCGGCTGAATGTAACAGAGG AACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGAC GCCAAACGCATTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGAT CCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTGGAGT TCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCG AGGACAGAGCCGCCTTGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGAC CGGGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACACGTTCG AGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCC GGCCCCTGGGGCCACCCCTTGTCAGCCGGGTGGGTAGGAACCGTAGACTCGCTCATC TCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAATAAACGCTCACTCCGAATTAG CGGTGTATTTCTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCTTTAATT CTAAATAAAAATTTATATTTTACTTTTTTATTGCTGGTTTAAGATGATTCAGATTATC CTTGTACTTTGAGGAGAAGTTTCTTATTTGGAGTCTTTTGGAAACAGTCTTAGTCTTT TAACTTGGAAAGATGAGGTATTAATCCCCTCCATTGCTCTCCAAAAGCCAATAAAGT GATTACACCCGA PNOC (SEQ ID NO: 25; NM_006228). GCCAGGAAGGCTTGCAGGTTCTGCTGTTTGGTTGCTGAAGGGGGTCAGTGTGTGTAT GTGTCATGGAGGTGGGCAGGGAAGGGGAGGGCTGTGCGTGGGGGAGAGGATATAT ATGCTGGTGTGGCTGAGAAAGCGGAACCGAGCCTCGCATCCATCGGAGGGAGCCGG GGACTGACAGCTCTCAGCACCTGCTTCCTGCTCCTGCACCATGAAAGTCCTGCTTTG TGACCTGCTGCTGCTCAGTCTCTTCTCCAGTGTGTTCAGCAGTTGTCAGAGGGACTGT CTCACATGCCAGGAGAAGCTCCACCCAGCCCTGGACAGCTTCGACCTGGAGGTGTG CATCCTCGAGTGTGAAGAGAAGGTCTTCCCCAGCCCCCTCTGGACTCCATGCACCAA GGTCATGGCCAGGAGCTCTTGGCAGCTCAGCCCTGCCGCCCCAGAGCATGTGGCGG CTGCTCTCTACCAGCCGAGAGCTTCGGAGATGCAGCATCTGCGGCGAATGCCCCGA GTCCGGAGCTTGTTCCAGGAGCAGGAAGAGCCCGAGCCTGGCATGGAGGAGGCTGG TGAGATGGAGCAGAAGCAGCTGCAGAAGAGATTTGGGGGCTTCACCGGGGCCCGGA AGTCGGCCAGGAAGTTGGCCAATCAGAAGCGGTTCAGTGAGTTTATGAGGCAATAC TTGGTCCTGAGCATGCAGTCCAGCCAGCGCCGGCGCACCCTGCACCAGAATGGTAA TGTGTAGCCGGAAGGGGCGCTCCTCCCAGCTGTACCGGCCACTGCAACCCATGAGC GTCCAGGTGATCCCCCAAACAGCATGTGCTCAGCCCCAGACCTGCCGCCTGGGAATC AGGATTCCTTCTTCCCCAAGGCACTGAGCGCCTGCAGATCCCGCAGGCTTCGTTTGC CTCCAGAACCTTCCCGTCTGATTGTTCCTCCCCAGCCCCCTGGCATGTTTCACCACAA CCCTGTTGCTACATCAGAGTGTATTTTTGTAATTCCTCTAGCTACCATTTCAATAGCC CCATCTCTCCTGCTCACCCGCCTCTTGCCCCTTCTAGGGGCAGGTGAAAGGAATAGG AAATTGAACCTGGGGTTTTGACTTGCCACTGCCATAACTTGTTTGTAAAAGAGCTGT TCTTTTTGACTGATTGTTTTAAACAACGATTTCTCCATTAAACTTCTACTGAGCAAAT GGTTAATAAAAAAAAAAAAAAAAAA PDE4B (SEQ ID NO: 26; NM_002600). AGAGCGCTGCGGCCGCGGCGGTGCAGCAGAGGCGCCTCGGGCAGGAGGAGGGCGG CTTCTGCGAGGGCAGCCTGAGGTATTAAAAAGTGTCAGCAAACTGCATTGAATAAC AGACATCCTAAGAGGGGATATTTTCCACCTCTATAATGAAGAAAAGCAGGAGTGTG ATGACGGTGATGGCTGATGATAATGTTAAAGATTATTTTGAATGTAGCTTGAGTAAA TCCTACAGTTCTTCCAGTAACACACTTGGGATCGACCTCTGGAGAGGGAGAAGGTGT TGCTCAGGAAACTTACAGTTACCACCACTGTCTCAAAGACAGAGTGAAAGGGCAAG GACTCCTGAGGGAGATGGTATTTCCAGGCCGACCACACTGCCTTTGACAACGCTTCC AAGCATTGCTATTACAACTGTAAGCCAGGAGTGCTTTGATGTGGAAAATGGCCCTTC CCCAGGTCGGAGTCCACTGGATCCCCAGGCCAGCTCTTCCGCTGGGCTGGTACTTCA CGCCACCTTTCCTGGGCACAGCCAGCGCAGAGAGTCATTTCTCTACAGATCAGACAG CGACTATGACTTGTCACCAAAGGCGATGTCGAGAAACTCTTCTCTTCCAAGCGAGCA ACACGGCGATGACTTGATTGTAACTCCTTTTGCCCAGGTCCTTGCCAGCTTGCGAAG TGTGAGAAACAACTTCACTATACTGACAAACCTTCATGGTACATCTAACAAGAGGTC CCCAGCTGCTAGTCAGCCTCCTGTCTCCAGAGTCAACCCACAAGAAGAATCTTATCA AAAATTAGCAATGGAAACGCTGGAGGAATTAGACTGGTGTTTAGACCAGCTAGAGA CCATACAGACCTACCGGTCTGTCAGTGAGATGGCTTCTAACAAGTTCAAAAGAATGC TGAACCGGGAGCTGACACACCTCTCAGAGATGAGCCGATCAGGGAACCAGGTGTCT GAATACATTTCAAATACTTTCTTAGACAAGCAGAATGATGTGGAGATCCCATCTCCT ACCCAGAAAGACAGGGAGAAAAAGAAAAAGCAGCAGCTCATGACCCAGATAAGTG GAGTGAAGAAATTAATGCATAGTTCAAGCCTAAACAATACAAGCATCTCACGCTTTG GAGTCAACACTGAAAATGAAGATCACCTGGCCAAGGAGCTGGAAGACCTGAACAAA TGGGGTCTTAACATCTTTAATGTGGCTGGATATTCTCACAATAGACCCCTAACATGC ATCATGTATGCTATATTCCAGGAAAGAGACCTCCTAAAGACATTCAGAATCTCATCT GACACATTTATAACCTACATGATGACTTTAGAAGACCATTACCATTCTGACGTGGCA TATCACAACAGCCTGCACGCTGCTGATGTAGCCCAGTCGACCCATGTTCTCCTTTCT ACACCAGCATTAGACGCTGTCTTCACAGATTTGGAGATCCTGGCTGCCATTTTTGCA GCTGCCATCCATGACGTTGATCATCCTGGAGTCTCCAATCAGTTTCTCATCAACACA AATTCAGAACTTGCTTTGATGTATAATGATGAATCTGTGTTGGAAAATCATCACCTT GCTGTGGGTTTCAAACTGCTGCAAGAAGAACACTGTGACATCTTCATGAATCTCACC AAGAAGCAGCGTCAGACACTCAGGAAGATGGTTATTGACATGGTGTTAGCAACTGA TATGTCTAAACATATGAGCCTGCTGGCAGACCTGAAGACAATGGTAGAAACGAAGA AAGTTACAAGTTCAGGCGTTCTTCTCCTAGACAACTATACCGATCGCATTCAGGTCC TTCGCAACATGGTACACTGTGCAGACCTGAGCAACCCCACCAAGTCCTTGGAATTGT

ATCGGCAATGGACAGACCGCATCATGGAGGAATTTTTCCAGCAGGGAGACAAAGAG CGGGAGAGGGGAATGGAAATTAGCCCAATGTGTGATAAACACACAGCTTCTGTGGA AAAATCCCAGGTTGGTTTCATCGACTACATTGTCCATCCATTGTGGGAGACATGGGC AGATTTGGTACAGCCTGATGCTCAGGACATTCTCGATACCTTAGAAGATAACAGGAA CTGGTATCAGAGCATGATACCTCAAAGTCCCTCACCACCACTGGACGAGCAGAACA GGGACTGCCAGGGTCTGATGGAGAAGTTTCAGTTTGAACTGACTCTCGATGAGGAA GATTCTGAAGGACCTGAGAAGGAGGGAGAGGGACACAGCTATTTCAGCAGCACAAA GACGCTTTGTGTGATTGATCCAGAAAACAGAGATTCCCTGGGAGAGACTGACATAG ACATTGCAACAGAAGACAAGTCCCCCGTGGATACATAATCCCCCTCTCCCTGTGGAG ATGAACATTCTATCCTTGATGAGCATGCCAGCTATGTGGTAGGGCCAGCCCACCATG GGGGCCAAGACCTGCACAGGACAAGGGCCACCTGGCCTTTCAGTTACTTGAGTTTGG AGTCAGAAAGCAAGACCAGGAAGCAAATAGCAGCTCAGGAAATCCCACGGTTGACT TGCCTTGATGGCAAGCTTGGTGGAGAGGGCTGAAGCTGTTGCTGGGGGCCGATTCTG ATCAAGACACATGGCTTGAAAATGGAAGACACAAAACTGAGAGATCATTCTGCACT AAGTTTCGGGAACTTATCCCCGACAGTGACTGAACTCACTGACTAATAACTTCATTT ATGAATCTTCTCACTTGTCCCTTTGTCTGCCAACCTGTGTGCCTTTTTTGTAAAACATT TTCATGTCTTTAAAATGCCTGTTGAATACCTGGAGTTTAGTATCAACTTCTACACAGA TAAGCTTTCAAAGTTGACAAACTTTTTTGACTCTTTCTGGAAAAGGGAAAGAAAATA GTCTTCCTTCTTTCTTGGGCAATATCCTTCACTTTACTACAGTTACTTTTGCAAACAG ACAGAAAGGATACACTTCTAACCACATTTTACTTCCTTCCCCTGTTGTCCAGTCCAAC TCCACAGTCACTCTTAAAACTTCTCTCTGTTTGCCTGCCTCCAACAGTACTTTTAACT TTTTGCTGTAAACAGAATAAAATTGAACAAATTAGGGGGTAGAAAGGAGCAGTGGT GTCGTTCACCGTGAGAGTCTGCATAGAACTCAGCAGTGTGCCCTGCTGTGTCTTGGA CCCTGCCCCCCACAGGAGTTGTACAGTCCCTGGCCCTGTTCCCTACCTCCTCTCTTCA CCCCGTTAGGCTGTTTTCAATGTAATGCTGCCGTCCTTCTCTTGCACTGCCTTCTGCG CTAACACCTCCATTCCTGTTTATAACCGTGTATTTATTACTTAATGTATATAATGTAA TGTTTTGTAAGTTATTAATTTATATATCTAACATTGCCTGCCAATGGTGGTGTTAAAT TTGTGTAGAAAACTCTGCCTAAGAGTTACGACTTTTTCTTGTAATGTTTTGTATTGTG TATTATATAACCCAAACGTCACTTAGTAGAGACATATGGCCCCCTTGGCAGAGAGGA CAGGGGTGGGCTTTTGTTCAAAGGGTCTGCCCTTTCCCTGCCTGAGTTGCTACTTCTG CACAACCCCTTTATGAACCAGTTTTGGAAACAATATTCTCACATTAGATACTAAATG GTTTATACTGAGCTTTTACTTTTGTATAGCTTGATAGGGGCAGGGGGCAATGGGATG TAGTTTTTACCCAGGTTCTATCCAAATCTATGTGGGCATGAGTTGGGTTATAACTGG ATCCTACTATCATTGTGGCTTTGGTTCAAAAGGAAACACTACATTTGCTCACAGATG ATTCTTCTGAATGCTCCCGAACTACTGACTTTGAAGAGGTAGCCTCCTGCCTGCCATT AAGCAGGAATGTCATGTTCCAGTTCATTACAAAAGAAAACAATAAAACAATGTGAA TTTTTATAATAAAATGTGAACTGATGTAGCAAATTACGCAAATGTGAAGCCTCTTCT GATAACACTTGTTAGGCCTCTTACTGATGTCAGTTTCAGTTTGTAAAATATGTTTCAT GCTTTCAGTTCAGCATTGTGACTCAGTAATTACAGAAAATGGCACAAATGTGCATGA CCAATGTATGTCTATGAACACTGCATTGTTTCAGGTGGACATTTTATCATTTTCAAAT GTTTCTCACAATGTATGTTATAGTATTATTATTATATATTGTGTTCAAATGCATTCTA AAGAGACTTTTATATGAGGTGAATAAAGAAAAGCATGATTAGATTAAAAAAA SCARB1 (SEQ ID NO: 27; NM_005505.4). GCTCAGGCCCCGCCCCTGCCGCCGGAATCCTGAAGCCCAAGGCTGCCCGGGGGCGG TCCGGCGGCGCCGGCGATGGGGCATAAAACCACTGGCCACCTGCCGGGCTGCTCCT GCGTGCGCTGCCGTCCCGGATCCACCGTGCCTCTGCGGCCTGCGTGCCCGGAGTCCC CGCCTGTGTCGTCTCTGTCGCCGTCCCCGTCTCCTGCCAGGCGCGGAGCCCTGCGAG CCGCGGGTGGGCCCCAGGCGCGCAGACATGGGCTGCTCCGCCAAAGCGCGCTGGGC TGCCGGGGCGCTGGGCGTCGCGGGGCTACTGTGCGCTGTGCTGGGCGCTGTCATGAT CGTGATGGTGCCGTCGCTCATCAAGCAGCAGGTCCTTAAGAACGTGCGCATCGACCC CAGTAGCCTGTCCTTCAACATGTGGAAGGAGATCCCTATCCCCTTCTATCTCTCCGTC TACTTCTTTGACGTCATGAACCCCAGCGAGATCCTGAAGGGCGAGAAGCCGCAGGT GCGGGAGCGCGGGCCCTACGTGTACAGGGAGTTCAGGCACAAAAGCAACATCACCT TCAACAACAACGACACCGTGTCCTTCCTCGAGTACCGCACCTTCCAGTTCCAGCCCT CCAAGTCCCACGGCTCGGAGAGCGACTACATCGTCATGCCCAACATCCTGGTCTTGG GTGCGGCGGTGATGATGGAGAATAAGCCCATGACCCTGAAGCTCATCATGACCTTG GCATTCACCACCCTCGGCGAACGTGCCTTCATGAACCGCACTGTGGGTGAGATCATG TGGGGCTACAAGGACCCCCTTGTGAATCTCATCAACAAGTACTTTCCAGGCATGTTC CCCTTCAAGGACAAGTTCGGATTATTTGCTGAGCTCAACAACTCCGACTCTGGGCTC TTCACGGTGTTCACGGGGGTCCAGAACATCAGCAGGATCCACCTCGTGGACAAGTG GAACGGGCTGAGCAAGGTTGACTTCTGGCATTCCGATCAGTGCAACATGATCAATG GAACTTCTGGGCAAATGTGGCCGCCCTTCATGACTCCTGAGTCCTCGCTGGAGTTCT ACAGCCCGGAGGCCTGCCGATCCATGAAGCTAATGTACAAGGAGTCAGGGGTGTTT GAAGGCATCCCCACCTATCGCTTCGTGGCTCCCAAAACCCTGTTTGCCAACGGGTCC ATCTACCCACCCAACGAAGGCTTCTGCCCGTGCCTGGAGTCTGGAATTCAGAACGTC AGCACCTGCAGGTTCAGTGCCCCCTTGTTTCTCTCCCATCCTCACTTCCTCAACGCTG ACCCGGTTCTGGCAGAAGCGGTGACTGGCCTGCACCCTAACCAGGAGGCACACTCC TTGTTCCTGGACATCCACCCGGTCACGGGAATCCCCATGAACTGCTCTGTGAAACTG CAGCTGAGCCTCTACATGAAATCTGTCGCAGGCATTGGACAAACTGGGAAGATTGA GCCTGTGGTCCTGCCGCTGCTCTGGTTTGCAGAGAGCGGGGCCATGGAGGGGGAGA CTCTTCACACATTCTACACTCAGCTGGTGTTGATGCCCAAGGTGATGCACTATGCCC AGTACGTCCTCCTGGCGCTGGGCTGCGTCCTGCTGCTGGTCCCTGTCATCTGCCAAA TCCGGAGCCAAGAGAAATGCTATTTATTTTGGAGTAGTAGTAAAAAGGGCTCAAAG GATAAGGAGGCCATTCAGGCCTATTCTGAATCCCTGATGACATCAGCTCCCAAGGGC TCTGTGCTGCAGGAAGCAAAACTGTAGGGTCCTGAGGACACCGTGAGCCAGCCAGG CCTGGCCGCTGGGCCTGACCGGCCCCCCAGCCCCTACACCCCGCTTCTCCCGGACTC TCCCAGCGGACAGCCCCCCAGCCCCACAGCCTGAGCCTCCCAGCTGCCATGTGCCTG TTGCACACCTGCACACACGCCCTGGCACACATACACACATGCGTGCAGGCTTGTGCA GACACTCAGGGATGGAGCTGCTGCTGAAGGGACTTGTAGGGAGAGGCTCGTCAACA AGCACTGTTCTGGAACCTTCTCTCCACGTGGCCCACAGGCCTGACCACAGGGGCTGT GGGTCCTGCGTCCCCTTCCTCGGGTGAGCCTGGCCTGTCCCGTTCAGCCGTTGGGCC CAGGCTTCCTCCCCTCCAAGGTGAAACACTGCAGTCCCGGTGTGGTGGCTCCCCATG CAGGACGGGCCAGGCTGGGAGTGCCGCCTTCCTGTGCCAAATTCAGTGGGGACTCA GTGCCCAGGCCCTGGCCACGAGCTTTGGCCTTGGTCTACCTGCCAGGCCAGGCAAAG CGCCTTTACACAGGCCTCGGAAAACAATGGAGTGAGCACAAGATGCCCTGTGCAGC TGCCCGAGGGTCTCCGCCCACCCCGGCCGGACTTTGATCCCCCCGAAGTCTTCACAG GCACTGCATCGGGTTGTCTGGCGCCCTTTTCCTCCAGCCTAAACTGACATCATCCTAT GGACTGAGCCGGCCACTCTCTGGCCGAAGTGGCCGCAGGCTGTGCCCCCGAGCTGC CCCCACCCCCTCACAGGGTCCCTCAGATTATAGGTGCCCAGGCTGAGGTGAAGAGG CCTGGGGGCCCTGCCTTCCGGGCGCTCCTGGACCCTGGGGCAAACCTGTGACCCTTT TCTACTGGAATAGAAATGAGTTTTATCATCTTTGAAAAATAATTCACTCTTGAAGTA ATAAACGTTTAAAAAAATGGGAAAAAAAAAAAAAAAAAA TMEM9B (SEQ ID NO: 28; NM_020644.2). GTGCGCGAACGGCTCCGGCCCGCACGGGTCGCCAGAGGCGACTGTGTGACACTCGG AGTTTGCTGGGGTCTCCGTGGGCGGGAGGACTTTCCAGCGCAATGGCGACTCCCTAA GCCCCGCAGCTTCTGCGCCCGGGAAAGATATCCAAGAGATGCAAAGCTCTACTGGG CCCAGGCTGCCACCCCAGAGGCCCCCTTCCGTCCCGGGGCCGGGGCTAGGCCAAGG CGGGCACCAGGACTGCCCAGCCTCCCGGCCCTTCGCACTGGTAACCGGTTCCGGGGC GGATGCTTTTTGCATCTGACCCGGCGCGCCCGGTGACGCCTTCGCGTCCAGACGGAA GTGCGGGCGGAGGATCCCCAGCCGGGTCCCAAGCCTGTGCCTGAGCCTGAGCCTGA GCCTGAGCCCGAGCCGGGAGCCGGTCGCGGGGGCTCCGGGCTGTGGGACCGCTGGG CCCCCAGCGATGGCGACCCTGTGGGGAGGCCTTCTTCGGCTTGGCTCCTTGCTCAGC CTGTCGTGCCTGGCGCTTTCCGTGCTGCTGCTGGCGCAGCTGTCAGACGCCGCCAAG AATTTCGAGGATGTCAGATGTAAATGTATCTGCCCTCCCTATAAAGAAAATTCTGGG CATATTTATAATAAGAACATATCTCAGAAAGATTGTGATTGCCTTCATGTTGTGGAG CCCATGCCTGTGCGGGGGCCTGATGTAGAAGCATACTGTCTACGCTGTGAATGCAAA TATGAAGAAAGAAGCTCTGTCACAATCAAGGTTACCATTATAATTTATCTCTCCATT TTGGGCCTTCTACTTCTGTACATGGTATATCTTACTCTGGTTGAGCCCATACTGAAGA GGCGCCTCTTTGGACATGCACAGTTGATACAGAGTGATGATGATATTGGGGATCACC AGCCTTTTGCAAATGCACACGATGTGCTAGCCCGCTCCCGCAGTCGAGCCAACGTGC TGAACAAGGTAGAATATGCACAGCAGCGCTGGAAGCTTCAAGTCCAAGAGCAGCGA AAGTCTGTCTTTGACCGGCATGTTGTCCTCAGCTAATTGGGAATTGAATTCAAGGTG ACTAGAAAGAAACAGGCAGACAACTGGAAAGAACTGACTGGGTTTTGCTGGGTTTC ATTTTAATACCTTGTTGATTTCACCAACTGTTGCTGGAAGATTCAAAACTGGAAGCA AAAACTTGCTTGATTTTTTTTTCTTGTTAACGTAATAATAGAGACATTTTTAAAAGCA CACAGCTCAAAGTCAGCCAATAAGTCTTTTCCTATTTGTGACTTTTACTAATAAAAAT AAATCTGCCTGTAAATTATCTTGAAGTCCTTTACCTGGAACAAGCACTCTCTTTTTCA CCACATAGTTTTAACTTGACTTTCAAGATAATTTTCAGGGTTTTTGTTGTTGTTGTTTT TTGTTTGTTTGTTTTGGTGGGAGAGGGGAGGGATGCCTGGGAAGTGGTTAACAACTT TTTTCAAGTCACTTTACTAAACAAACTTTTGTAAATAGACCTTACCTTCTATTTTCGA GTTTCATTTATATTTTGCAGTGTAGCCAGCCTCATCAAAGAGCTGACTTACTCATTTG ACTTTTGCACTGACTGTATTATCTGGGTATCTGCTGTGTCTGCACTTCATGGTAAACG GGATCTAAAATGCCTGGTGGCTTTTCACAAAAAGCAGATTTTCTTCATGTACTGTGA TGTCTGATGCAATGCATCCTAGAACAAACTGGCCATTTGCTAGTTTACTCTAAAGAC TAAACATAGTCTTGGTGTGTGTGGTCTTACTCATCTTCTAGTACCTTTAAGGACAAAT CCTAAGGACTTGGACACTTGCAATAAAGAAATTTTATTTTAAACCCAAGCCTCCCTG GATTGATAATATATACACATTTGTCAGCATTTCCGGTCGTGGTGAGAGGCAGCTGTT

TGAGCTCCAATGTGTGCAGCTTTGAACTAGGGCTGGGGTTGTGGGTGCCTCTTCTGA AAGGTCTAACCATTATTGGATAACTGGCTTTTTTCTTCCTATGTCCTCTTTGGAATGT AACAATAAAAATAATTTTTGAAACATCCATCAGTGTATCTATCTATGTCTCCTAGTTT TTTCCTCCTCCCTCTTTTGCTGTATAATGAGATTGAAGATATAAAGACATTTTGTACC CTGTAAAAAAAA PPP6R3 (SEQ ID NO: 29; XM_005274081). AACTCAAGGCCTGCTTGATACGTCCGCCATTTTGGGCGCTTCGCTGATGGTGTCGGT GAGCGCGTTTCCCGCCTGAGCGCAACTAGCGGCGGGTCGTGGGCACCTCCAGGAGA GCTTGTTTCATATCCATATCCCACTGTATTCCTGCTAATCTGCTAATGCAGTAAATTG GAGGAAAACTGTTACCAGGATAACCTGTAATGGGCAAGGAGCCACAAAGAAGAAA ACATTTCTTTTAATTTTTAAACTTGGTTTGAAAGACCAGCATGTTTTGGAAATTTGAT CTTCACTCATCATCCCACATAGACACACTTCTAGAAAGAGAAGATGTAACACTGAAG GAGTTAATGGATGAGGAAGATGTTTTACAGGAATGTAAAGCTCAGAACCGCAAACT TATAGAGTTTCTGTTAAAAGCAGAATGTCTCGAAGATTTAGTCTCATTCATTATAGA AGAACCACCTCAAGACATGGATGAAAAGATCAGATACAAGTATCCAAATATATCTT GTGAGTTGCTCACTTCTGATGTCTCCCAGATGAATGATAGACTGGGAGAAGATGAAT CCTTGCTAATGAAATTATATAGCTTCCTCCTAAACGATTCCCCTTTGAATCCACTACT TGCCAGTTTCTTCAGCAAGGTGCTAAGTATTCTTATCAGCAGAAAACCAGAACAGAT TGTGGATTTCTTAAAGAAGAAGCATGATTTTGTAGACCTTATTATAAAGCACATAGG AACTTCTGCTATCATGGATTTGTTGCTCAGGCTCCTGACGTGTATCGAACCTCCACAG CCCAGGCAAGATGTGCTGAATTGGTTAAATGAGGAGAAAATTATCCAGAGGCTTGT GGAAATAGTTCATCCATCGCAAGAAGAAGATCGACATTCAAATGCATCACAATCAC TTTGTGAAATTGTTCGCCTGAGCAGAGACCAGATGTTACAAATTCAGAACAGTACAG AGCCCGACCCCCTGCTTGCCACTCTAGAAAAGCAAGAAATTATAGAGCAGCTTCTAT CAAATATTTTCCACAAGGAGAAAAATGAGTCAGCCATAGTCAGTGCAATCCAGATA TTGCTGACTTTACTTGAGACACGACGACCAACATTTGAAGGCCATATAGAGATCTGC CCACCAGGCATGAGCCATTCAGCTTGTTCAGTAAACAAGAGTGTTCTAGAAGCCATC AGAGGAAGACTTGGATCTTTTCATGAACTCCTGCTGGAGCCACCCAAGAAAAGTGT GATGAAGACCACATGGGGTGTGCTGGATCCTCCTGTGGGGAATACCCGGTTGAATGT CATTAGGTTGATATCCAGCCTGCTTCAAACCAATACCAGCAGTATAAATGGGGACCT TATGGAGCTGAATAGCATTGGAGTCATATTGAACATGTTCTTCAAGTATACATGGAA TAACTTTTTGCATACACAAGTGGAAATTTGTATTGCACTGATTCTTGCAAGTCCTTTT GAAAACACAGAAAATGCCACAATTACCGATCAAGACTCCACTGGTGATAATTTGTT ATTAAAACATCTTTTCCAAAAATGTCAATTAATAGAACGAATACTTGAAGCCTGGGA AATGAATGAGAAGAAACAGGCTGAGGGAGGAAGACGGCATGGTTACATGGGACAC CTAACGAGGATAGCTAACTGTATCGTGCACAGCACTGACAAGGGCCCCAACAGTGC ATTAGTGCAGCAGCTTATCAAAGATCTTCCCGACGAAGTCAGGGAACGATGGGAGA CGTTCTGCACAAGCTCCTTAGGAGAAACTAACAAGAGGAACACGGTAGATCTAGTT ACAACCTGCCATATTCATTCATCCAGTGATGATGAAATTGACTTTAAAGAAACGGGT TTCTCACAGGATTCTTCTTTGCAGCAAGCCTTTTCTGATTATCAGATGCAACAAATGA CGTCCAATTTTATTGACCAGTTTGGCTTCAACGATGAGAAGTTTGCAGATCAAGATG ACATTGGCAATGTTTCTTTTGATCGAGTATCAGACATCAACTTTACTCTCAATACAAA TGAAAGTGGAAATATTGCCTTGTTTGAAGCATGTTGTAAGGAAAGAATACAACAGTT TGATGATGGTGGCTCTGATGAGGAAGATATATGGGAGGAAAAGCACATCGCATTCA CACCAGAATCCCAAAGACGATCCAGCTCGGGGAGTACAGACAGTGAGGAAAGTAC AGACTCTGAAGAAGAAGATGGAGCAAAGCAAGACTTGTTTGAACCCAGCAGTGCCA ACACGGAGGATAAAATGGAGGTGGACCTGAGTGAACCACCCAACTGGTCAGCTAAC TTTGATGTCCCAATGGAAACAACCCACGGTGCTCCATTGGATTCTGTGGGATCTGAT GTCTGGAGCACAGAGGAGCCGATGCCAACTAAAGAGACGGGCTGGGCTTCTTTTTC AGAGTTCACGTCTTCCCTGAGCACAAAAGATTCTTTAAGGAGTAATTCTCCAGTGGA AATGGAAACCAGCACTGAACCCATGGACCCTCTGACTCCCAGTGCGGCTGCCCTGG CAGTGCAGCCAGAAGCGGCAGGCAGTGTGGCCATGGAAGCCAGCTCTGACGGAGA GGAGGATGCAGAAAGTACAGACAAGGTAACTGAGACAGTGATGAATGGCGGCATG AAGGAAACGCTCAGCCTCACTGTAGATGCCAAGACAGAGACTGCGGTCTTCAAAAG TGAGGAAGGGAAACTGTCTACCTCTCAAGATGCTGCTTGTAAAGACGCAGAGGAGT GTCCCGAGACTGCAGAGGCGAAGTGCGCGGCGCCCAGGCCTCCCAGCAGCAGTCCC GAGCAGAGTGCCTCCGATGCCTGTCTGTTGCTCCTTAGGACTGGCCAACCAAGCGCA CCAGGTGACACTTCAGTGAATGGCCCTGTATGACGGGTGACGTCTGCTGCTGCTGAC TGAGGACTGCAGACCGCCACCACTCAGGGGCTCTGGAGGGGTCAGCTGGAGCCCAC CAAGCTGTCACTGCTGCACTCACTCTGCAAGGGATCAGGACCAGCAACCTTTATATT CTAGATTCTAAGACATTGTACAGAGAAATTCAGAAGTGTAAAAATATTGCACATTGA CAAATACCAAGAATTTTTGCGTATGTTTATATTGTATTGTTCTAAATAATGGGTAGCC TGTGAAATAAGATCTTGCCACCCATGTAATAATAGTAGTAATACTATAGTTAAAATG GCTGTAAGAATAGTTTTATAAAAGTGAATACACAGATCTATTGTATTTGAAACATAA CTTTGACAATTATTAGTGTGACCAAAGTATTAGGCGGTTTTCATACATTTTTCACCTT GTACAAAATTATGAATTCATTTTTCCTCCAGGCCGACAAGGAGTTGTAGAATGAAAA TGCCCTCTAAGTGTTATTTTGGTTGTTCTAACTTACAAAAGTGATTTTGAATAAGAAA TATTTGGTGTTCTTTTTATAACCAGTTTTTGATTGGTAATTGTTTTCTGTATTGTTTAA AACGGATCAAAAATGTAAGTCTATTGGTAGAGATTAAGTAAAGTATTTATTGCTACA TCATAGTTGATAAATTGATGTTATCGTAAAGCCATATGTTCTGTTCAAGTCTTGTTTG CTTGAAATGATTATTCCTACAAGTGAAACACTAGACTATTTGGAGTGTATATGGCTT GTGTTTTGGGATTTTTTTTTTTTTTTTTTGGCTTTTGTTTTTGTTTGTTTTTTTGTTTCAT TTGGTAGTTCATCTGCCTTTTAACCCATTCACCAAAATTTACCTTGTTAACAAGCATC ACCAATGAACATTTCAGAGCAATCTGCATATTTAACAGACCTAAAATAAATCCTATT AGGCAAGTCAGTTGAAAATGCTCGTGCTGCTAATGGAATTAGAGTGCGTTCATTTTA CAGGCTAGTATTTTAAAAGTAGAAATCAAAATCTGGCACCGAAGCATGCTAATTGTT TACTGTACCTTGTGAGGTTTTCACTCATAAATTTAAACCAGTGTATTTTTTTAGAACT GGTTTGTGTATATATATAGTGATTATGGATACTAATTCAATGTAATTTATAATTTTCT ATGTCAATACAAAAATACATCACAGCCTTCTCAAACAGCTCAAGCAATATATTGTAT ATTGCCATATCGTCTGGTGAAAGGGTTAAATTACTTCACCTCTTGCACTTTTAGATGC AAATCAGTTTTTCATTTCTGTAATAGAAAATTATTCACGTATTTTTACATCATTTGTTT TTCCTGACCAGTATTTAAAACCAAAAGGATATTCTGAAAAATGGCCAACAATTTTTT TAGAAGTAGCATCCCAAGCAGCGTGCCTAAACATTACATTGCATATGGAAATAAAA GAATCAAACGTCTAATGCCTTATTATTTCTGATTTCCTTTTTCATTTTAAGTGGTGTG GAGATTCCAGCACTCCCAGGACAGTGGAGTCAGCAGTAAGCCCTGGGACAGGTGGC AAGGGTGGGTCCCTTGACCTTTGCACGCCTCCTCAGGAACCCCCTTTCCCGGGTGAG CCCCTCTCTGAAGAGACTGTCCTTGGGCCTCCTCTGGAAGCAGCACCCCCAGAGGAC AGGGCTCCTCCTGCTTGCCTCAGGGCTGCCTGACTTGAATGGCGTTGGACCTCGGGG ATTACTGGTAGATAATATGCTCTGGTCTCGCCTGGTGGTGAGTTTTGCCAGCCATGG CCAGGGTTTGGCTCCACTGGTGGCACACGTGGCCTCCGTGGTATGGACCTGGTGGCT TCTCCATCCCACTGTGGCCTCTGTGGTATGGACCTGGTGGCTTCTCCATCCTACCCAA GGTAACAGTGTCTTGCTTCATCCCACTGACTGCTGGGAGAGAGCCTCTGGGACTTTT CTTTGGGGCATCATTTTGTTTTGTCTTTCGTAGCAGGGAAAGGATATGACAATGGGG AGGACAGTTCTTTTGGAGGTTGGAGGGGCCAAGCCAAGGACAGGAGCAAGTGTGCC CTCATTTTGTTTCTACTTTTAATTTCTGTGTGTTGGCCATACTGAATTATGAGACTAA CAGATGTCTACAATACAATACCTGTATTCAAAATAACAAAAATAAAGCCTGATTCTT TGTTTCTAGAAA

Sequence CWU 1

1

3114184DNAHomo sapiens 1atttaagggc ccgcctctcc tggctcacag ctgcttgctg ctccagcctt gccctcccag 60agctgccgga cgctcgcggg tctcggaacg catcccgccg cgggggcttc ggccgtggca 120tgggcgccgc gggcctgctc ggggttttct tggctctcgt cgcaccgggg gtcctcggga 180tttcttgtgg ctctcctccg cctatcctaa atggccggat tagttattat tctaccccca 240ttgctgttgg taccgtgata aggtacagtt gttcaggtac cttccgcctc attggagaaa 300aaagtctatt atgcataact aaagacaaag tggatggaac ctgggataaa cctgctccta 360aatgtgaata tttcaataaa tattcttctt gccctgagcc catagtacca ggaggataca 420aaattagagg ctctacaccc tacagacatg gtgattctgt gacatttgcc tgtaaaacca 480acttctccat gaacggaaac aagtctgttt ggtgtcaagc aaataatatg tgggggccga 540cacgactacc aacctgtgta agtgttttcc ctctcgagtg tccagcactt cctatgatcc 600acaatggaca tcacacaagt gagaatgttg gctccattgc tccaggattg tctgtgactt 660acagctgtga atctggttac ttgcttgttg gagaaaagat cattaactgt ttgtcttcgg 720gaaaatggag tgctgtcccc cccacatgtg aagaggcacg ctgtaaatct ctaggacgat 780ttcccaatgg gaaggtaaag gagcctccaa ttctccgggt tggtgtaact gcaaactttt 840tctgtgatga agggtatcga ctgcaaggcc caccttctag tcggtgtgta attgctggac 900agggagttgc ttggaccaaa atgccagtat gtgaagaaat tttttgccca tcacctcccc 960ctattctcaa tggaagacat ataggcaact cactagcaaa tgtctcatat ggaagcatag 1020tcacttacac ttgtgacccg gacccagagg aaggagtgaa cttcatcctt attggagaga 1080gcactctccg ttgtacagtt gatagtcaga agactgggac ctggagtggc cctgccccac 1140gctgtgaact ttctacttct gcggttcagt gtccacatcc ccagatccta agaggccgaa 1200tggtatctgg gcagaaagat cgatatacct ataacgacac tgtgatattt gcttgcatgt 1260ttggcttcac cttgaagggc agcaagcaaa tccgatgcaa tgcccaaggc acatgggagc 1320catctgcacc agtctgtgaa aaggaatgcc aggcccctcc taacatcctc aatgggcaaa 1380aggaagatag acacatggtc cgctttgacc ctggaacatc tataaaatat agctgtaacc 1440ctggctatgt gctggtggga gaagaatcca tacagtgtac ctctgagggg gtgtggacac 1500cccctgtacc ccaatgcaaa gtggcagcgt gtgaagctac aggaaggcaa ctcttgacaa 1560aaccccagca ccaatttgtt agaccagatg tcaactcttc ttgtggtgaa gggtacaagt 1620taagtgggag tgtttatcag gagtgtcaag gcacaattcc ttggtttatg gagattcgtc 1680tttgtaaaga aatcacctgc ccaccacccc ctgttatcta caatggggca cacaccggga 1740gttccttaga agattttcca tatggaacca cggtcactta cacatgtaac cctgggccag 1800aaagaggagt ggaattcagc ctcattggag agagcaccat ccgttgtaca agcaatgatc 1860aagaaagagg cacctggagt ggccctgctc ccctgtgtaa actttccctc cttgctgtcc 1920agtgctcaca tgtccatatt gcaaatggat acaagatatc tggcaaggaa gccccatatt 1980tctacaatga cactgtgaca ttcaagtgtt atagtggatt tactttgaag ggcagtagtc 2040agattcgttg caaagctgat aacacctggg atcctgaaat accagtttgt gaaaaaggct 2100gccagtcacc tcctgggctc caccatggtc gtcatacagg tggaaatacg gtcttctttg 2160tctctgggat gactgtagac tacacttgtg accctggcta tttgcttgtg ggaaacaaat 2220ccattcactg tatgccttca ggaaattgga gtccttctgc cccacggtgt gaagaaacat 2280gccagcatgt gagacagagt cttcaagaac ttccagctgg ttcacgtgtg gagctagtta 2340atacgtcctg ccaagatggg taccagttga ctggacatgc ttatcagatg tgtcaagatg 2400ctgaaaatgg aatttggttc aaaaagattc cactttgtaa agttattcac tgtcaccctc 2460caccagtgat tgtcaatggg aagcacacag gcatgatggc agaaaacttt ctatatggaa 2520atgaagtctc ttatgaatgt gaccaaggat tctatctcct gggagagaaa aaattgcagt 2580gcagaagtga ttctaaagga catggatctt ggagcgggcc ttccccacag tgcttacgat 2640ctcctcctgt gactcgctgc cctaatccag aagtcaaaca tgggtacaag ctcaataaaa 2700cacattctgc atattcccac aatgacatag tgtatgttga ctgcaatcct ggcttcatca 2760tgaatggtag tcgcgtgatt aggtgtcata ctgataacac atgggtgcca ggtgtgccaa 2820cttgtatcaa aaaagccttc atagggtgtc cacctccgcc taagacccct aacgggaacc 2880atactggtgg aaacatagct cgattttctc ctggaatgtc aatcctgtac agctgtgacc 2940aaggctacct gctggtggga gaggcactcc ttctttgcac acatgaggga acctggagcc 3000aacctgcccc tcattgtaaa gaggtaaact gtagctcacc agcagatatg gatggaatcc 3060agaaagggct ggaaccaagg aaaatgtatc agtatggagc tgttgtaact ctggagtgtg 3120aagatgggta tatgctggaa ggcagtcccc agagccagtg ccaatcggat caccaatgga 3180accctcccct ggcggtttgc agatcccgtt cacttgctcc tgtcctttgt ggtattgctg 3240caggtttgat acttcttacc ttcttgattg tcattacctt atacgtgata tcaaaacaca 3300gagcacgcaa ttattataca gatacaagcc agaaagaagc ttttcattta gaagcacgag 3360aagtatattc tgttgatcca tacaacccag ccagctgatc agaagacaaa ctggtgtgtg 3420cctcattgct tggaattcag cggaatattg attagaaaga aactgctcta atatcagcaa 3480gtctctttat atggcctcaa gatcaatgaa atgatgtcat aagcgatcac ttcctatatg 3540cacttattct caagaagaac atctttatgg taaagatggg agcccagttt cactgccata 3600tactcttcaa ggactttctg aagcctcact tatgagatgc ctgaagccag gccatggcta 3660taaacaatta catggctcta aaaagttttg ccctttttaa ggaaggcact aaaaagagct 3720gtcctggtat ctagacccat cttctttttg aaatcagcat actcaatgtt actatctgct 3780tttggttata atgtgttttt aattatctaa agtatgaagc attttctggg gttatgatgg 3840ctttaccttt attaggaagt atggttttat tttgatagta gcttcctcct ctggtggtgt 3900taatcatttc atttttaccc ttacttggtt tgagtttctc tcacattact gtatatactt 3960tgcctttcca taatcactca gtgattgcaa tttgcacaag tttttttaaa ttatgggaat 4020caagatttaa tcctagagat ttggtgtaca attcaggctt tggatgtttc tttagcagtt 4080ttgtgataag ttctagttgc ttgtaaaatt tcacttaata atgtgtacat tagtcattca 4140ataaattgta attgtaaaga aaacatacaa aaaaaaaaaa aaaa 418421442DNAHomo sapiens 2agtcgggcag ctctccgggc cggcgtggga gcccgcgctc caaagcccgg tggggggagg 60ggcgctcacg caaccgccac tgtctggagc gggctcgcct ctgcggcggc actcaccgcc 120cgggctttac tgaagcggag tctagcatgt gcggctgctc cacagcggtg tgggtggcgg 180cggctcctct gcagcagcct cggcagtagg ggtcacggtg gccaagccca ccgtggagct 240catctgagag ttgtaaggta cgggactgcc tcggtctttg ggacgccccg tctggtagca 300tcccagatcc agcacgttcc ttccggccct gcaccccggc ccggtgcctc acaccccgct 360accccatgca tccagactct aaggcagccc ctgcatctca gtcctgacat cgctgtccct 420ggagcatcct ccgctggagc tggagcttga caggatcggc ttcgccgtcg cccagcgtct 480ggcccaagac ggggcccacg tggtagtcag ccgccggaag cagcagaatg tggaccaggc 540agtggccacg ctgcaggggg aggggctgag catgacgggc actgtgtgcc atgtggggaa 600gatgaaggac tgggagcggc tggtggccac agtgagctgc agggaaatgg gcacagagcc 660aggaggtgga aaagggagcc agcctgagcc tccttccctg ctttcctgga cagcattggg 720cttcagtcct tacaatgtca gtaaaacagc cttgctgggc ctcaacaaga ccttggccat 780agagctggcc ccaaggaaca ttagggtgaa ctgcctagca cctggactta tcaagactag 840cttcagcagg atgctctgga tggacaagga aaaagaggaa agcatgaaag aaaccctgcg 900gataagaagg ttaggcgagc cagaggattc tcttggcatc gtgtctttcc tgtgctctga 960agatgccagc tacctcactg gggaaacagt gatggtgggt ggaggaaccc cgtcccgcct 1020ctgaggaccc ggagacagcc cacaggccag agttgggctc tagctcctgg tgctgttcct 1080gcattcaccc actggccttt cccacctctg ctcaccttac tgttcacctc atcaaatcag 1140ttctgccctg tgaaaagatc cagccttccc tgccgtcaag gtggtgtctt actcgggatt 1200cctgctgttg ttgtggcctt gggtaaaggc ctcccctgag aacacaggac aggcctgctg 1260acaaggctga gtctaccttg gcaaagacca agatattttt tgcccaggcc actggggaat 1320ttgaggggag atgagagaga aggaagctgg agtggaagga gcagagttgc aaattaacaa 1380cttgcaaatg aggtgcaaat aaaatgcaga tgattgcgcg gctttgaatc gaaaaaaaaa 1440aa 144232168DNAHomo sapiens 3ggagttagcc tcgctcaggg cgcggctaag gcgcccagat ggcctgcggg cgccaccacg 60tccctggtcc cagctcggga gcacatcaga ggcttagagg cgagtgggaa gggactcaga 120cagtgcagga cgagaaacgc ccgcggcacc aaagcccctc agagcgtcgc ccccgcctct 180agttctagaa agtcagtttc ccggcactgg caccccggaa cctcaggggc tgccgagctg 240ggggggcgct caagctgcga ggatccgggc tgcccgcgag acgaggagcg ggcgcccagg 300atggggtgca tgaagtccaa gttcctccag gtcggaggca atacattctc aaaaactgaa 360accagcgcca gcccacactg tcctgtgtac gtgccggatc ccacatccac catcaagccg 420gggcctaata gccacaacag caacacacca ggaatcaggg aggcaggctc tgaggacatc 480atcgtggttg ccctgtatga ttacgaggcc attcaccacg aagacctcag cttccagaag 540ggggaccaga tggtggtcct agaggaatcc ggggagtggt ggaaggctcg atccctggcc 600acccggaagg agggctacat cccaagcaac tatgtcgccc gcgttgactc tctggagaca 660gaggagtggt ttttcaaggg catcagccgg aaggacgcag agcgccaact gctggctccc 720ggcaacatgc tgggctcctt catgatccgg gatagcgaga ccactaaagg aagctactct 780ttgtccgtgc gagactacga ccctcggcag ggagataccg tgaaacatta caagatccgg 840accctggaca acgggggctt ctacatatcc ccccgaagca ccttcagcac tctgcaggag 900ctggtggacc actacaagaa ggggaacgac gggctctgcc agaaactgtc ggtgccctgc 960atgtcttcca agccccagaa gccttgggag aaagatgcct gggagatccc tcgggaatcc 1020ctcaagctgg agaagaaact tggagctggg cagtttgggg aagtctggat ggccacctac 1080aacaagcaca ccaaggtggc agtgaagacg atgaagccag ggagcatgtc ggtggaggcc 1140ttcctggcag aggccaacgt gatgaaaact ctgcagcatg acaagctggt caaacttcat 1200gcggtggtca ccaaggagcc catctacatc atcacggagt tcatggccaa aggaagcttg 1260ctggactttc tgaaaagtga tgagggcagc aagcagccat tgccaaaact cattgacttc 1320tcagcccaga ttgcagaagg catggccttc atcgagcaga ggaactacat ccaccgagac 1380ctccgagctg ccaacatctt ggtctctgca tccctggtgt gtaagattgc tgactttggc 1440ctggcccggg tcattgagga caacgagtac acggctcggg aaggggccaa gttccccatc 1500aagtggacag ctcctgaagc catcaacttt ggctccttca ccatcaagtc agacgtctgg 1560tcctttggta tcctgctgat ggagatcgtc acctacggcc ggatccctta cccagggatg 1620tcaaaccctg aagtgatccg agctctggag cgtggatacc ggatgcctcg cccagagaac 1680tgcccagagg agctctacaa catcatgatg cgctgctgga aaaaccgtcc ggaggagcgg 1740ccgaccttcg aatacatcca gagtgtgctg gatgacttct acacggccac agagagccag 1800taccaacagc agccatgata gggaggacca gggcagggcc agggggtgcc caggtggtgg 1860ctgcaaggtg gctccagcac catccgccag ggcccacacc cccttcctac tcccagacac 1920ccaccctcgc ttcagccaca gtttcctcat ctgtccagtg ggtaggttgg actggaaaat 1980ctctttttga ctcttgcaat ccacaatctg acattctcag gaagccccca agttgatatt 2040tctatttcct ggaatggttg gattttagtt acagctgtga tttggaaggg aaactttcaa 2100aatagtgaaa tgaatattta aataaaagat ataaatgcca aagtctttac caaaaaaaaa 2160aaaaaaaa 216844801DNAHomo sapiens 4aaagggggaa aagaaagtgc ggcggaaagt aagaggctca ctggggaaga ctgccgggat 60ccaggtctcc ggggtccgct ttggccagag gcgcggaagg aagcagtgcc cggcgacact 120gcacccatcc cggctgcttt tgctgcgccc tctcagcttc ccaagaaagg catcgtcatg 180tgatcatcac ctaagaacta gaacatcagc aggccctaga agcctcactc ttgcccctcc 240ctttaatatc tcaaaggatg acacttctgt ggtgtgtagt gagtctctac ttttatggaa 300tcctgcaaag tgatgcctca gaacgctgcg atgactgggg actagacacc atgaggcaaa 360tccaagtgtt tgaagatgag ccagctcgca tcaagtgccc actctttgaa cacttcttga 420aattcaacta cagcacagcc cattcagctg gccttactct gatctggtat tggactaggc 480aggaccggga ccttgaggag ccaattaact tccgcctccc cgagaaccgc attagtaagg 540agaaagatgt gctgtggttc cggcccactc tcctcaatga cactggcaac tatacctgca 600tgttaaggaa cactacatat tgcagcaaag ttgcatttcc cttggaagtt gttcaaaaag 660acagctgttt caattccccc atgaaactcc cagtgcataa actgtatata gaatatggca 720ttcagaggat cacttgtcca aatgtagatg gatattttcc ttccagtgtc aaaccgacta 780tcacttggta tatgggctgt tataaaatac agaattttaa taatgtaata cccgaaggta 840tgaacttgag tttcctcatt gccttaattt caaataatgg aaattacaca tgtgttgtta 900catatccaga aaatggacgt acgtttcatc tcaccaggac tctgactgta aaggtagtag 960gctctccaaa aaatgcagtg ccccctgtga tccattcacc taatgatcat gtggtctatg 1020agaaagaacc aggagaggag ctactcattc cctgtacggt ctattttagt tttctgatgg 1080attctcgcaa tgaggtttgg tggaccattg atggaaaaaa acctgatgac atcactattg 1140atgtcaccat taacgaaagt ataagtcata gtagaacaga agatgaaaca agaactcaga 1200ttttgagcat caagaaagtt acctctgagg atctcaagcg cagctatgtc tgtcatgcta 1260gaagtgccaa aggcgaagtt gccaaagcag ccaaggtgaa gcagaaagtg ccagctccaa 1320gatacacagt ggaactggct tgtggttttg gagccacagt cctgctagtg gtgattctca 1380ttgttgttta ccatgtttac tggctagaga tggtcctatt ttaccgggct cattttggaa 1440cagatgaaac cattttagat ggaaaagagt atgatattta tgtatcctat gcaaggaatg 1500cggaagaaga agaatttgta ttactgaccc tccgtggagt tttggagaat gaatttggat 1560acaagctgtg catctttgac cgagacagtc tgcctggggg aattgtcaca gatgagactt 1620tgagcttcat tcagaaaagc agacgcctcc tggttgttct aagccccaac tacgtgctcc 1680agggaaccca agccctcctg gagctcaagg ctggcctaga aaatatggcc tctcggggca 1740acatcaacgt cattttagta cagtacaaag ctgtgaagga aacgaaggtg aaagagctga 1800agagggctaa gacggtgctc acggtcatta aatggaaagg ggaaaaatcc aagtatccac 1860agggcaggtt ctggaagcag ctgcaggtgg ccatgccagt gaagaaaagt cccaggcggt 1920ctagcagtga tgagcagggc ctctcgtatt catctttgaa aaatgtatga aaggaataat 1980gaaaagggta aaaagaacaa ggggtgctcc aggaagaaag agtcccccca gtcttcattc 2040gcagtttatg gtttcatagg caaaaataat ggtctaagcc tcccaatagg gataaattta 2100gggtgactgt gtggctgact attctgcttc ctcaggcaac actaaagttt agaaagatat 2160catcaacgtt ctgtcaccag tctctgatgc cactatgttc tttgcaggca aagacttgtt 2220caatgcgaat ttccccttct acattgtcta tccctgtttt tatatgtctc cattcttttt 2280aaaatcttaa catatggagc agcctttcct atgaatttaa atatgccttt aaaataagtc 2340actgttgaca gggtcatgag tttccgagta tagttttctt tttatcttat ttttactcgt 2400ccgttgaaaa gataatcaag gcctacattt tagctgagga taatgaactt ttttcctcat 2460tcggctgtat aatacataac cacagcaaga ctgacatcca cttaggatga tacaaagcag 2520tgtaactgaa aatgtttctt ttaattgatt taaaggactt gtcttctata ccacccttgt 2580cctcatctca ggtaatttat gaaatctatg taaacttgaa aaatatttct taatttttgt 2640ttttgctcca gtcaattcct gattatccac aggtcaaccc acattttttc attccttctc 2700cctatctgct tatatcgcat tgctcattta gagtttgcag gaggctccat actaggttca 2760gtctgaaaga aatctcctaa tggtgctata gagagggagg taacagaaag actcttttag 2820ggcatttttc tgactcatga aaagagcaca gaaaaggatg tttggcaatt tgtcttttaa 2880gtcttaacct tgctaatgtg aatactggga aagtgatttt ttctcactcg tttttgttgc 2940tccattgtaa agggcggagg tcagtcttag tggccttgag agttgctttt ggcattaata 3000ttctaagaga attaactgta tttcctgtca cctattcact agtgcaggaa atatacttgc 3060tccaaataag tcagtatgag aagtcactgt caatgaaagt tgttttgttt gttttcagta 3120atattttgct gtttttaaga cttggaaaac taagtgcaga gtttacagag tggtaaatat 3180ctatgttaca tgtagattat acatatatat acacacgtgt atatgagata tatatcttat 3240atctccacaa acacaaatta tatatataca tatccacaca catacattac atatatctgt 3300gtatataaat ccacatgcac atgaaatata tatatatata taatttgtgt gtgtgtatgt 3360gtatgtatat gactttaaat agctatgggt acaatattaa aaaccactgg aactcttgtc 3420cagtttttaa attatgtttt tactggaatg tttttgtgtc agtgttttct gtacatatta 3480tttgttaatt cacagctcac agagtgatag ttgtcatagt tcttgccttc cctaagttta 3540tataaataac ttaagtattg ctacagttta tctaggttgc agtggcatct gctgtgcaca 3600gagcttccat ggtcactgct aagcagtagc cagccatcgg gcattaattg atttcctact 3660atattcccag cagacacatt tagaaactaa gctatgttaa cctcagtgct caactatttg 3720aactgttgag tgataaagga aacaaatata actgtaaatg aatcttggta tcctgtgaaa 3780cagaataatt cgtaatttaa gaaagccctt atcccggtaa catgaatgtt gatgaacaaa 3840tgtaaaatta tatcctatat ttaagtaccc ataataaatc atttccctct ataagtgtta 3900ttgattattt taaattgaaa aaagtttcac ttggatgaaa aaagtagaaa agtaggtcat 3960tcttggatct actttttttt agccttatta atatttttcc ctattagaaa ccacaattac 4020tccctctatt aacccttcac ttactagacc agaaaagaac ttattccaga taagctttga 4080atatcaattc ttacataaac tttaggcaaa cagggaatag tctagtcacc aaaggaccat 4140tctcttgcca atgctgcatt ccttttgcac ttttggattc catatttatc ccaaatgctg 4200ttgggcaccc ctagaaatac cttgatgttt tttctattta tatgcctgcc tttggtactt 4260aattttacaa atgctgtaat ataaagcata tcaagtttat gtgatacgta tcattgcaag 4320agaatttgtt tcaagatttt tttttaatgt tccagaagat ggccaataga gaacattcaa 4380gggaaatggg gaaacataat ttagagaaca agaacaaacc atgtctcaaa tttttttaaa 4440aaaaattaat ggttttaaat atatgctata gggacgttcc atgcccaggt taacaaagaa 4500ctgtgatata tagagtgtct aattacaaaa tcatatacga tttatttaat tctcttctgt 4560attgtaactt agatgattcc caaggactct aataaaaaat cacttcattg tatttggaaa 4620caaaaacatc attcattaat tacttatttt ctttccatag gttttaatat tttgagagtg 4680tcttttttat ttcattcatg aacttttgta tttttcattt ttcatttgat ttgtaaattt 4740acttatgtta aaaataaacc atttattttc agctttgaat tttaaaaaaa aaaaaaaaaa 4800a 480151514DNAHomo sapiens 5gagccctgcc tgcgcccgcc cccgaagcgg cgcgggacgc ctggcgccgt ccgcgatccg 60cagggctgcc cgcttaggct taggcccggc ccgctggcaa agccgagccg cagcatttta 120tttcgttcgt ggtttccgca caggctggag tttcgtgggt tgggtcgtac ttgggacctc 180ggcgaagagg acccgtttat ttttttttct ttccaaaatg gcagcctcca gtcgcgcaca 240agtgttatct ctgtaccggg cgatgctgag agagagcaag cgtttcagcg cctacaatta 300cagaacatat gctgtcagga ggataagaga tgccttcaga gaaaataaaa atgtaaagga 360tcctgtagaa attcaaaccc tagtgaataa agccaagaga gaccttggag taattcgtcg 420acaggtccac attggccaac tgtattcaac tgacaagctg atcattgaga atcgagacat 480gcccaggacc tagcaagccg gggaccagcc accagtggcg gccagggacc accttcagca 540tccactctct gtttgagatg ggggctccca aaaccagctt acaatagcct tttgcgctgc 600ctgtcctgtg ggagctgata aaccaagtca catttgcatt ctgttgcagg cttagtgaaa 660aaggactgct gtctttcctt ggttcaagtg ttagaatgga gagctggagt tcgttcagaa 720tagtgctgtg tgttaccacg tctcccctgc accccattcc taccttgtag ctcatgacca 780ttgtgtatag catttctaca ctttgtttct tggtccttgg caataaaaag aatgatctcc 840ctgagccttt gaccccagat aaacccctcc caattaatgc attttcattt cctactgata 900caaggcctgg agagggctgt tgggggccct cagggagggt tcaactctga gacgagaact 960gccttggtga aggcaagttc aagcaccact tgagactggg ggcagcatgg agtagggcag 1020ggctacgggg atacacggtg caccctgcaa cttatacctg agcccagtac aacaaaggtg 1080acgggtgtgt aggtacacac ccagagatgg agcactgcag atcagcaacc tcagccccac 1140ctgggaattt gctggaaatg caggctcaag cccctcccca cacctggtga atgagagagc 1200cccagcctga cccaagccca gggcgactcc cataccctga agcctggggc atgctgggca 1260gcaccggtgc ccaaatctgg ctggtggaca gaagcacctg gagagttgga gagcttttta 1320aaaagacatc tctcagcact tccctctctg cagattctga ctcagtaagt gaggggtgag 1380gcacagtcat ttttctctat tctgaagctc tcccactgtt ttcaatgttt aaccaactgg 1440ggacccctgc tctttaagta tattacaggt aataaagata ttgtttgtat gcttttaaaa 1500aaaaaaaaaa aaaa 151462379DNAHomo sapiens 6gacccccgag ctgtgctgct cgcggccgcc accgccgggc cccggccgtc cctggctccc 60ctcctgcctc gagaagggca gggcttctca gaggcttggc gggaaaaaga acggagggag 120ggatcgcgct gagtataaaa gccggttttc ggggctttat ctaactcgct gtagtaattc 180cagcgagagg cagagggagc gagcgggcgg ccggctaggg tggaagagcc gggcgagcag 240agctgcgctg cgggcgtcct gggaagggag atccggagcg aatagggggc ttcgcctctg 300gcccagccct cccgctgatc ccccagccag cggtccgcaa cccttgccgc atccacgaaa 360ctttgcccat agcagcgggc gggcactttg cactggaact tacaacaccc gagcaaggac 420gcgactctcc cgacgcgggg aggctattct gcccatttgg ggacacttcc ccgccgctgc 480caggacccgc ttctctgaaa ggctctcctt gcagctgctt agacgctgga tttttttcgg 540gtagtggaaa accagcagcc tcccgcgacg atgcccctca acgttagctt caccaacagg

600aactatgacc tcgactacga ctcggtgcag ccgtatttct actgcgacga ggaggagaac 660ttctaccagc agcagcagca gagcgagctg cagcccccgg cgcccagcga ggatatctgg 720aagaaattcg agctgctgcc caccccgccc ctgtccccta gccgccgctc cgggctctgc 780tcgccctcct acgttgcggt cacacccttc tcccttcggg gagacaacga cggcggtggc 840gggagcttct ccacggccga ccagctggag atggtgaccg agctgctggg aggagacatg 900gtgaaccaga gtttcatctg cgacccggac gacgagacct tcatcaaaaa catcatcatc 960caggactgta tgtggagcgg cttctcggcc gccgccaagc tcgtctcaga gaagctggcc 1020tcctaccagg ctgcgcgcaa agacagcggc agcccgaacc ccgcccgcgg ccacagcgtc 1080tgctccacct ccagcttgta cctgcaggat ctgagcgccg ccgcctcaga gtgcatcgac 1140ccctcggtgg tcttccccta ccctctcaac gacagcagct cgcccaagtc ctgcgcctcg 1200caagactcca gcgccttctc tccgtcctcg gattctctgc tctcctcgac ggagtcctcc 1260ccgcagggca gccccgagcc cctggtgctc catgaggaga caccgcccac caccagcagc 1320gactctgagg aggaacaaga agatgaggaa gaaatcgatg ttgtttctgt ggaaaagagg 1380caggctcctg gcaaaaggtc agagtctgga tcaccttctg ctggaggcca cagcaaacct 1440cctcacagcc cactggtcct caagaggtgc cacgtctcca cacatcagca caactacgca 1500gcgcctccct ccactcggaa ggactatcct gctgccaaga gggtcaagtt ggacagtgtc 1560agagtcctga gacagatcag caacaaccga aaatgcacca gccccaggtc ctcggacacc 1620gaggagaatg tcaagaggcg aacacacaac gtcttggagc gccagaggag gaacgagcta 1680aaacggagct tttttgccct gcgtgaccag atcccggagt tggaaaacaa tgaaaaggcc 1740cccaaggtag ttatccttaa aaaagccaca gcatacatcc tgtccgtcca agcagaggag 1800caaaagctca tttctgaaga ggacttgttg cggaaacgac gagaacagtt gaaacacaaa 1860cttgaacagc tacggaactc ttgtgcgtaa ggaaaagtaa ggaaaacgat tccttctaac 1920agaaatgtcc tgagcaatca cctatgaact tgtttcaaat gcatgatcaa atgcaacctc 1980acaaccttgg ctgagtcttg agactgaaag atttagccat aatgtaaact gcctcaaatt 2040ggactttggg cataaaagaa cttttttatg cttaccatct tttttttttc tttaacagat 2100ttgtatttaa gaattgtttt taaaaaattt taagatttac acaatgtttc tctgtaaata 2160ttgccattaa atgtaaataa ctttaataaa acgtttatag cagttacaca gaatttcaat 2220cctagtatat agtacctagt attataggta ctataaaccc taattttttt tatttaagta 2280cattttgctt tttaaagttg atttttttct attgttttta gaaaaaataa aataactggc 2340aaatatatca ttgagccaaa tcttaaaaaa aaaaaaaaa 237973215DNAHomo sapiens 7aacccggggc tccgagccgg agccgagtct gcgcctgggg gaggaccatg cggcagtagc 60agccatgctg ccctttctgc tggccacact gggcaccaca gccctcaaca acagcaaccc 120caaggactac tgctacagcg cccgcatccg cagcactgtc ctgcagggcc tgccctttgg 180gggcgtcccc accgtgctgg ctctcgactt catgtgcttc cttgcactgc tgttcttatt 240ctctatcctc cggaaggtgg cctgggacta tgggcggctg gccttggtga cagatgcaga 300caggcttcgg cggcaggaga gggaccgagt ggaacaggaa tatgtggctt cagctatgca 360cggggacagc catgaccggt atgagcgtct cacctctgtc tccagctccg ttgactttga 420ccaaagggac aatggtttct gttcctggct gacagccatc ttcaggataa aggatgatga 480gatccgggac aaatgtgggg gcgatgccgt gcactacctg tcctttcagc ggcacatcat 540cgggctgctg gtggttgtgg gcgtcctctc cgtaggcatc gtgctgcctg tcaacttctc 600aggggacctg ctggagaaca atgcctacag ctttgggaga accaccattg ccaacttgaa 660atcagggaac aacctgctat ggctgcacac ctccttcgcc ttcctgtatc tgctgctcac 720cgtctacagc atgcgtagac acacctccaa gatgcgctac aaggaggatg atctggtgaa 780gcggaccctc ttcatcaatg gaatctccaa atatgcagag tcagaaaaga tcaagaagca 840ttttgaggaa gcctacccca actgcacagt tctcgaagcc cgcccgtgtt acaacgtggc 900tcgcctaatg ttcctcgatg cagagaggaa gaaggccgag cggggaaagc tgtacttcac 960aaacctccag agcaaggaga acgtgcctac catgatcaac cccaagccct gtggccacct 1020ctgctgctgt gtggtgcgag gctgtgagca ggtggaggcc attgagtact acacaaagct 1080ggagcagaag ctgaaggaag actacaagcg ggagaaggag aaggtgaatg agaagcctct 1140tggcatggcc tttgtcacct tccacaatga gactatcacc gccatcatcc tgaaggactt 1200caacgtgtgt aaatgccagg gctgcacctg ccgtggggag ccacgcccct catcctgcag 1260cgagtccctg cacatctcca actggaccgt gtcctatgcc cctgaccctc agaacatcta 1320ctgggagcac ctctccatcc gaggcttcat ctggtggctg cgctgcctgg tcatcaatgt 1380cgtcctcttc atcctcctct tcttcctcac cactccagcc atcatcatca ccaccatgga 1440caagttcaac gtcaccaagc ctgtggagta cctcaacaac cccatcatca cccagttctt 1500ccccaccctg ctgctgtggt gcttctcggc cctccttccc accatcgtct actactcagc 1560cttctttgaa gcccactgga cacgctctgg ggagaacagg acaaccatgc acaagtgcta 1620cactttcctc atcttcatgg tgctgctcct accctcgctg ggactgagca gcctggacct 1680cttcttccgc tggctctttg ataagaaatt cttggctgag gcagctattc ggtttgagtg 1740tgtgttcctg cccgacaacg gcgccttctt cgtgaactac gtcattgcct cagcctttat 1800cggcaacgcc atggacctgc tgcgcatccc aggcctgctc atgtacatga tccggctctg 1860cctggcgcgc tcggccgccg agaggcgcaa cgtgaagcgg catcaggcct acgagttcca 1920gtttggcgca gcctacgcct ggatgatgtg cgtcttcacg gtggtcatga cctacagtat 1980cacctgcccc atcatcgtgc ccttcgggct catgtacatg ctgctgaagc acctggtaga 2040caggtacaat ctctactacg cctacctgcc ggccaagctg gacaagaaga tccactcggg 2100ggctgtgaac caggtggtgg ccgcgcccat cctctgcctc ttctggctgc tcttcttttc 2160caccatgcgc acggggttcc tagctcccac gtctatgttc acatttgtgg tcctggtcat 2220caccatcgtc atctgtctct gccacgtctg ctttggacac ttcaaatacc tcagtgccca 2280caactacaag attgagcaca cggagacaga tactgtggac cccagaagca atggacggcc 2340ccccactgct gctgctgtcc ccaaatctgc gaaatacatc gctcaggtgc tgcaggactc 2400agaggtggac ggggatgggg atggggctcc tgggagctca ggggatgagc ccccatcatc 2460ctcatcccaa gatgaggagt tgctgatgcc acccgacgcc ctcacggaca cagacttcca 2520gtcttgcgag gacagcctca tagagaatga gattcaccag taaggggagg gaggggccct 2580ggaggccaca tcctgcccca ccccaccccc actcccacgg acactaaaac gctaataatt 2640tattagatct aaagcccctt cctccccagc ccctgctttc attaaggtat ttaaacttgg 2700gggtttcact gctctccccc atgatggagg gagggagccc cccaacctca gtgaggagag 2760ccccgagccg gccccggggc aaagaggggt gcagagggag ttcccccaga tcagtacccc 2820ccacccctcc ccagctagta gcatgaccag gagagggtta atgagagcca agaggagtac 2880ctggtgcacc tggtgccggt ggctggagac ctggggggca ggtggatctg gggctgttcc 2940cccccctccg ttttttccac cccacagttc ctcctgggat ctggccctcc agggaagtgg 3000agcctccagc ccctagggga tgcatgaggg gggagggggt gctgagtggg aggaagagtc 3060aggctcacag ctggggtggc ctgggggtgg gggtgggcaa ggctgacact ggaaaatggg 3120tttttgcact gttttttttt tggttttttt gttctttttt gtttttttcc tttaaaataa 3180aaacaaagaa aagctctgaa aaaaaaaaaa aaaaa 321582581DNAHomo sapiens 8ccggggccag ggaccagtgg tgggaggagg ctgcggcgct agatgcggac acctggaccg 60ccgcgccgag gctcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg 120tcaccgtggc cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc 180tcgtgggctc ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact 240tcgagcgtgg cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc 300agctggtcag aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca 360tcacgctgaa gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg 420gcgatgtcga ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc 480acattctcaa gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga 540tggagtggaa ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc 600gtgatatcca gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga 660tggagaacct gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg 720ccgactttga gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc 780actggcagga agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga 840tccggcgctg cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca 900gcctggagcg gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg 960actttgagct gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc 1020tggccgctcc catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca 1080tccagctcaa ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat 1140acgactggct tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca 1200tcacccacct tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc 1260agctgcctgc tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg 1320caatcaacac caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca 1380acgccacagg gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct 1440atgcctccct gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca 1500tcccctacta cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca 1560cggccgaggt ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc 1620tgcaggactt cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct 1680tccccaagtc ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca 1740ccgcctccgc ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc 1800ccaatgcgcc cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg 1860agcagatcgt ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt 1920gggcgctgag ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt 1980ttatcgagaa gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg 2040tcagcgtgat tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag 2100accggattcc gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca 2160gctgccccag ccagatggac tccagcctgc ctggcaggct gtctggccag gcctcttggc 2220agtcacatct cttcctccga ggccagtacc tttccattta ttctttgatc ttcagggaac 2280tgcatagatt gatcaaagtg taaacaccat agggacccat tctacacaga gcaggactgc 2340acagcgtcct gtccacaccc agctcagcat ttccacacca agcagcaaca gcaaatcacg 2400accactgata gatgtctatt cttgttggag acatgggatg attattttct gttctatttg 2460tgcttagtcc aattccttgc acatagtagg tacccaattc aattactatt gaatgaatta 2520agaattggtt gccataaaaa taaatcagtt catttaaaat gaaaaaaaaa aaaaaaaaaa 2580a 258192272DNAHomo sapiens 9agtctccctc cagcgggcgg cgactccggg ttccccctcg cgccctctcg cagaggctcg 60cccccttccc cgcccaccgt ccctgcgagc gcgggcggcg gcggtgggcg tgtgcgcgcg 120tgaaggacgc cgcctctctc tcgctcctgc gttcgcaggc ggcggctggc ggccggcttc 180tcgctcgggc agcggcggcg gcggcggcgg cggcttccgg agtcccgctg cgaagatgct 240caaagtcacg gtgccctcct gctccgcctc gtcctgctct tcggtcaccg ccagtgcggc 300cccggggacc gcgagcctcg tcccggatta ctggatcgac ggctccaaca gggatgcgct 360gagcgatttc ttcgaggtgg agtcggagct gggacggggt gctacatcca ttgtgtacag 420atgcaaacag aaggggaccc agaagcctta tgctctcaaa gtgttaaaga aaacagtgga 480caaaaaaatc gtaagaactg agataggagt tcttcttcgc ctctcacatc caaacattat 540aaaacttaaa gagatatttg aaacccctac agaaatcagt ctggtcctag aactcgtcac 600aggaggagaa ctgtttgata ggattgtgga aaagggatat tacagtgagc gagatgctgc 660agatgccgtt aaacaaatcc tggaggcagt tgcttatcta catgaaaatg ggattgtcca 720tcgtgatctc aaaccagaga atcttcttta tgcaactcca gccccagatg caccactcaa 780aatcgctgat tttggactct ctaaaattgt ggaacatcaa gtgctcatga agacagtatg 840tggaacccca gggtactgcg cacctgaaat tcttagaggt tgtgcctatg gacctgaggt 900ggacatgtgg tctgtaggaa taatcaccta catcttactt tgtggatttg aaccattcta 960tgatgaaaga ggcgatcagt tcatgttcag gagaattctg aattgtgaat attactttat 1020ctccccctgg tgggatgaag tatctctaaa tgccaaggac ttggtcagaa aattaattgt 1080tttggatcca aagaaacggc tgactacatt tcaagctctc cagcatccgt gggtcacagg 1140taaagcagcc aattttgtac acatggatac cgctcaaaag aagctccaag aattcaatgc 1200ccggcgtaag cttaaggcag cggtgaaggc tgtggtggcc tcttcccgcc tgggaagtgc 1260cagcagcagc catggcagca tccaggagag ccacaaggct agccgagacc cttctccaat 1320ccaagatggc aacgaggaca tgaaagctat tccagaagga gagaaaattc aaggcgatgg 1380ggcccaagcc gcagttaagg gggcacaggc tgagctgatg aaggtgcaag ccttagagaa 1440agttaaaggt gcagatataa atgctgaaga ggcccccaaa atggtgccca aggcagtgga 1500ggatgggata aaggtggctg acctggaact agaggagggc ctagcagagg agaagctgaa 1560gactgtggag gaggcagcag ctcccagaga agggcaagga agctctgctg tgggttttga 1620agttccacag caagatgtga tcctgccaga gtactaaaca gcttccttca gatctggaag 1680ccaaacaccg gcattttatg tactttgtcc ttcagcaaga aaggtgtgga agcatgatat 1740gtactatagt gattctgttt ttgaggtgca aaaaacatac atatatacca gttggtaatt 1800ctaacttcaa tgcatgtgac tgctttatga aaataatagt gtcttctatg gcatgtaatg 1860gatacctaat accgatgagt taaatcttgc aagttaacac aacgtaacac ttaaaagcat 1920acattttcag caaccagtgg cacatatttg aagtgaatag tagcaaattg tttttgcttt 1980gaaaatctag ccatcctaca tcctttggat ttcttcacaa ggcagtaatt cctttgaact 2040actgcttagc taatactagg tagtgctaaa agacatgttc ccataacttt tacaacattt 2100tactttttat cattgatgtg ttcaaactgt ttacaaggag atgcttatag atgatagttg 2160tacatatgtg caaaaaaaaa tccacttgca atggtaagaa attgaagtat ccttaaaggc 2220catgaagcca tatgtcccta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 2272102175DNAHomo sapiens 10gttgtatatc agggccgcgc tgagctgcgc cagctgaggt gtgagcagct gccgaagtca 60gttccttgtg gagccggagc tgggcgcgga ttcgccgagg caccgaggca ctcagaggag 120gcgccatgtc agaaccggct ggggatgtcc gtcagaaccc atgcggcagc aaggcctgcc 180gccgcctctt cggcccagtg gacagcgagc agctgagccg cgactgtgat gcgctaatgg 240cgggctgcat ccaggaggcc cgtgagcgat ggaacttcga ctttgtcacc gagacaccac 300tggagggtga cttcgcctgg gagcgtgtgc ggggccttgg cctgcccaag ctctaccttc 360ccacggggcc ccggcgaggc cgggatgagt tgggaggagg caggcggcct ggcacctcac 420ctgctctgct gcaggggaca gcagaggaag accatgtgga cctgtcactg tcttgtaccc 480ttgtgcctcg ctcaggggag caggctgaag ggtccccagg tggacctgga gactctcagg 540gtcgaaaacg gcggcagacc agcatgacag atttctacca ctccaaacgc cggctgatct 600tctccaagag gaagccctaa tccgcccaca ggaagcctgc agtcctggaa gcgcgagggc 660ctcaaaggcc cgctctacat cttctgcctt agtctcagtt tgtgtgtctt aattattatt 720tgtgttttaa tttaaacacc tcctcatgta cataccctgg ccgccccctg ccccccagcc 780tctggcatta gaattattta aacaaaaact aggcggttga atgagaggtt cctaagagtg 840ctgggcattt ttattttatg aaatactatt taaagcctcc tcatcccgtg ttctcctttt 900cctctctccc ggaggttggg tgggccggct tcatgccagc tacttcctcc tccccacttg 960tccgctgggt ggtaccctct ggaggggtgt ggctccttcc catcgctgtc acaggcggtt 1020atgaaattca ccccctttcc tggacactca gacctgaatt ctttttcatt tgagaagtaa 1080acagatggca ctttgaaggg gcctcaccga gtgggggcat catcaaaaac tttggagtcc 1140cctcacctcc tctaaggttg ggcagggtga ccctgaagtg agcacagcct agggctgagc 1200tggggacctg gtaccctcct ggctcttgat acccccctct gtcttgtgaa ggcaggggga 1260aggtggggtc ctggagcaga ccaccccgcc tgccctcatg gcccctctga cctgcactgg 1320ggagcccgtc tcagtgttga gccttttccc tctttggctc ccctgtacct tttgaggagc 1380cccagctacc cttcttctcc agctgggctc tgcaattccc ctctgctgct gtccctcccc 1440cttgtccttt cccttcagta ccctctcagc tccaggtggc tctgaggtgc ctgtcccacc 1500cccaccccca gctcaatgga ctggaagggg aagggacaca caagaagaag ggcaccctag 1560ttctacctca ggcagctcaa gcagcgaccg ccccctcctc tagctgtggg ggtgagggtc 1620ccatgtggtg gcacaggccc ccttgagtgg ggttatctct gtgttagggg tatatgatgg 1680gggagtagat ctttctagga gggagacact ggcccctcaa atcgtccagc gaccttcctc 1740atccacccca tccctcccca gttcattgca ctttgattag cagcggaaca aggagtcaga 1800cattttaaga tggtggcagt agaggctatg gacagggcat gccacgtggg ctcatatggg 1860gctgggagta gttgtctttc ctggcactaa cgttgagccc ctggaggcac tgaagtgctt 1920agtgtacttg gagtattggg gtctgacccc aaacaccttc cagctcctgt aacatactgg 1980cctggactgt tttctctcgg ctccccatgt gtcctggttc ccgtttctcc acctagactg 2040taaacctctc gagggcaggg accacaccct gtactgttct gtgtctttca cagctcctcc 2100cacaatgctg aatatacagc aggtgctcaa taaatgattc ttagtgactt tacttgtaaa 2160aaaaaaaaaa aaaaa 2175112403DNAHomo sapiens 11ggggccttgc cttccgcact cgggcgcagc cgggtggatc tcgagcaggt gcggagcccc 60gggcggcggg cgcgggtgcg agggatccct gacgcctctg tccctgtttc tttgtcgctc 120ccagcctgtc tgtcgtcgtt ttggcgcccc cgcctccccg cggtgcgggg ttgcacaccg 180atcctgggct tcgctcgatt tgccgccgag gcgcctccca gacctagagg ggcgctggcc 240tggagcagcg ggtcgtctgt gtcctctctc ctctgcgccg cgcccgggga tccgaagggt 300gcggggctct gaggaggtga cgcgcggggc ctcccgcacc ctggccttgc ccgcattctc 360cctctctccc aggtgtgagc agcctatcag tcaccatgtc cgcagcctgg atcccggctc 420tcggcctcgg tgtgtgtctg ctgctgctgc cggggcccgc gggcagcgag ggagccgctc 480ccattgctat cacatgtttt accagaggct tggacatcag gaaagagaaa gcagatgtcc 540tctgcccagg gggctgccct cttgaggaat tctctgtgta tgggaacata gtatatgctt 600ctgtatcgag catatgtggg gctgctgtcc acaggggagt aatcagcaac tcagggggac 660ctgtacgagt ctatagccta cctggtcgag aaaactattc ctcagtagat gccaatggca 720tccagtctca aatgctttct agatggtctg cttctttcac agtaactaaa ggcaaaagta 780gtacacagga ggccacagga caagcagtgt ccacagcaca tccaccaaca ggtaaacgac 840taaagaaaac acccgagaag aaaactggca ataaagattg taaagcagac attgcatttc 900tgattgatgg aagctttaat attgggcagc gccgatttaa tttacagaag aattttgttg 960gaaaagtggc tctaatgttg ggaattggaa cagaaggacc acatgtgggc cttgttcaag 1020ccagtgaaca tcccaaaata gaattttact tgaaaaactt tacatcagcc aaagatgttt 1080tgtttgccat aaaggaagta ggtttcagag ggggtaattc caatacagga aaagccttga 1140agcatactgc tcagaaattc ttcacggtag atgctggagt aagaaaaggg atccccaaag 1200tggtggtggt atttattgat ggttggcctt ctgatgacat cgaggaagca ggcattgtgg 1260ccagagagtt tggtgtcaat gtatttatag tttctgtggc caagcctatc cctgaagaac 1320tggggatggt tcaggatgtc acatttgttg acaaggctgt ctgtcggaat aatggcttct 1380tctcttacca catgcccaac tggtttggca ccacaaaata cgtaaagcct ctggtacaga 1440agctgtgcac tcatgaacaa atgatgtgca gcaagacctg ttataactca gtgaacattg 1500cctttctaat tgatggctcc agcagtgttg gagatagcaa tttccgcctc atgcttgaat 1560ttgtttccaa catagccaag acttttgaaa tctcggacat tggtgccaag atagctgctg 1620tacagtttac ttatgatcag cgcacggagt tcagtttcac tgactatagc accaaagaga 1680atgtcctagc tgtcatcaga aacatccgct atatgagtgg tggaacagct actggtgatg 1740ccatttcctt cactgttaga aatgtgtttg gccctataag ggagagcccc aacaagaact 1800tcctagtaat tgtcacagat gggcagtcct atgatgatgt ccaaggccct gcagctgctg 1860cacatgatgc aggaatcact atcttctctg ttggtgtggc ttgggcacct ctggatgacc 1920tgaaagatat ggcttctaaa ccgaaggagt ctcacgcttt cttcacaaga gagttcacag 1980gattagaacc aattgtttct gatgtcatca gaggcatttg tagagatttc ttagaatccc 2040agcaataatg gtaacatttt gacaactgaa agaaaaagta caaggggatc cagtgtgtaa 2100attgtattct cataatactg aaatgcttta gcatactaga atcagataca aaactattaa 2160gtatgtcaac agccatttag gcaaataagc actcctttaa agccgctgcc ttctggttac 2220aatttacagt gtactttgtt aaaaacactg ctgaggcttc ataatcatgg ctcttagaaa 2280ctcaggaaag aggagataat gtggattaaa accttaagag ttctaaccat gcctactaaa 2340tgtacagata tgcaaattcc atagctcaat aaaagaatct gatacttaga ccaaaaaaaa 2400aaa 2403121315DNAHomo sapiens 12ctactctgtc accgcccctg ggaagagtgg aacccatact tgctggtctg atccatgcac 60aaggcggggc tgctaggcct ctgtgcccgg gcttggaatt cggtgcggat ggccagctcc 120gggatgaccc gccgggaccc gctcgcaaat aaggtggccc tggtaacggc ctccaccgac 180gggatcggct tcgccatcgc ccggcgtttg gcccaggacg gggcccatgt ggtcgtcagc 240agccggaagc agcagaatgt ggaccaggcg gtggccacgc tgcaggggga ggggctgagc

300gtgacgggca ccgtgtgcca tgtggggaag gcggaggacc gggagcggct ggtggccacg 360gctgtgaagc ttcatggagg tatcgatatc ctagtctcca atgctgctgt caaccctttc 420tttggaagca taatggatgt cactgaggag gtgtgggaca agactctgga cattaatgtg 480aaggccccag ccctgatgac aaaggcagtg gtgccagaaa tggagaaacg aggaggcggc 540tcagtggtga tcgtgtcttc catagcagcc ttcagtccat ctcctggctt cagtccttac 600aatgtcagta aaacagcctt gctgggcctg accaagaccc tggccataga gctggcccca 660aggaacatta gggtgaactg cctagcacct ggacttatca agactagctt cagcaggatg 720ctctggatgg acaaggaaaa agaggaaagc atgaaagaaa ccctgcggat aagaaggtta 780ggcgagccag aggattgtgc tggcatcgtg tctttcctgt gctctgaaga tgccagctac 840atcactgggg aaacagtggt ggtgggtgga ggaaccccgt cccgcctctg aggaccggga 900gacagcccac aggccagagt tgggctctag ctcctggtgc tgttcccgca ttcacccact 960ggcctttccc acctctgctc accttactgt tcacctcatc aaatcagttc tgccctgtga 1020aaagatccag ccttccctgc cgtcaaggtg gcgtcttact cgggatttct gctgttgttg 1080tggccttggg taaaggcctc ccctgagaac acaggacagg cctgctgaca aggctgagtc 1140taccttggca aagaccaaga tattttttcc cgggccactg gggaatctga ggggtgatgg 1200gagagaagga acctggagtg gaaggagcag agttgcaaat taacaacttg caaatgaggt 1260gcaaataaaa tgcagatgat tgcgcggctt tgaatccaaa aaaaaaaaaa aaaaa 1315133661DNAHomo sapiens 13cccaagactg tccccgctgg aggcggtaga gggatccaga agtaatgaga tgctaatgag 60tcgcgaataa agcccgggcg gcgccccgcg cccctcgcgg aagcccacac tccgcgcgac 120tccaggcgca cgccccgggc cgccccgcat cccagcatcc ccgcccgatc tcggcgtttc 180cgcccccgcc cccgcccccg ccctcccacc cgctcagacc tggttgccag cccaacagga 240agcggcccct cccggcttcg gagccgccgc cactcatctc tgcccagctg ctgccctccc 300caggaggcct ccatggcttc acctacctcc accaacccag cgcatgccca ctttgagagc 360ttcctgcagg cccagctgtg ccaggacgtg ctgagcagct tccaggagct gtgtggggcc 420ctggggctgg aacccggtgg ggggctgccc cagtaccaca agatcaagga ccagctcaac 480tactggagcg ccaagtcact gtggaccaag ctggacaagc gagcaggcca gcctgtctac 540cagcagggcc gggcctgcac cagcaccaag tgcctggtgg tgggtgctgg accttgcggg 600ctgcgggtcg ctgtggagct ggcgctgctg ggggcccgag tggtgctggt ggaaaagcgc 660accaagttct ctcgccacaa cgtgctccac ctctggccct tcaccatcca cgacctgcgg 720gcactcggtg ctaagaagtt ctacgggcgc ttctgcaccg gcaccctgga ccacatcagc 780atcaggcagc tccagctgct tctgctgaag gtagcattgc tgctgggggt ggaaattcac 840tggggtgtca ctttcactgg cctccagccc cctcctagga aggggagtgg ctggcgtgcc 900cagctccaac ccaacccccc tgcccagctg gccaactatg aatttgacgt ccttatctcg 960gctgcaggag gtaaattcgt ccctgaaggc ttcaaagttc gagaaatgcg aggcaaactg 1020gccattggca tcacagccaa ctttgtgaat ggacgcaccg tggaggagac acaggtgccg 1080gagatcagtg gtgtagccag gatctacaac cagagcttct tccagagcct tctcaaagcc 1140acaggcattg atctggagaa cattgtgtac tacaaggacg acacccacta ctttgtgatg 1200acagccaaga agcagtgcct gctgcggctg ggggtgctgc gccaggactg gccagacacc 1260aatcggctgc tgggcagtgc caatgtggtg cccgaggctc tgcagcgctt tacccgggca 1320gctgctgact ttgccaccca tggcaagctc gggaaactag agtttgccca ggatgcccat 1380gggcagcctg atgtctctgc ctttgacttc acgagcatga tgcgggcaga gagttctgct 1440cgtgtgcaag agaagcatgg cgcccgcctg ctgctgggac tggtggggga ctgcctggtg 1500gagcccttct ggcccctggg cactggagtg gcacggggct tcctggcagc ctttgatgca 1560gcctggatgg tgaagcggtg ggcagagggc gctgagtccc tagaggtgtt ggctgagcgt 1620gagagcctgt accagcttct gtcacagaca tccccagaaa acatgcatcg caatgtggcc 1680cagtatgggc tggacccagc cacccgctac cccaacctga acctccgggc agtgaccccc 1740aatcaggtac gagacctgta tgatgtgcta gccaaggagc ctgtgcagag gaacaacgac 1800aagacagata cagggatgcc agccaccggg tcggcaggca cccaggagga gctgctacgc 1860tggtgccagg agcagacagc tgggtacccg ggagtccacg tctccgattt gtcttcctcc 1920tgggctgatg ggctagctct gtgtgccctg gtgtaccggc tgcagcctgg cctgctggaa 1980ccctcagagc tgcaggggct gggagctctg gaagcaactg cttgggcact aaaggtggca 2040gagaatgagc tgggcatcac accggtggtg tctgcacagg ccgtggtagc agggagtgac 2100ccactgggcc tcattgccta cctcagccac ttccacagtg ccttcaagag catggcccac 2160agcccaggcc ctgtcagcca ggcctcccca gggacctcca gtgctgtatt attccttagt 2220aaacttcaga ggaccctgca gcgatcccgg gccaaggaaa atgcagagga tgctggtggc 2280aagaagctgc gcttggagat ggaggccgag accccaagta ctgaggtgcc acctgaccca 2340gagcctggtg tacccctgac acccccatcc caacaccagg aggccggtgc tggggacctg 2400tgtgcacttt gtggggaaca cctctatgtc ctggaacgcc tctgtgtcaa cggccatttc 2460ttccaccgga gctgcttccg ctgccatacc tgtgaggcca cactgtggcc aggtggctac 2520gagcagcacc caggagatgg acatttctac tgcctccagc acctgcccca gacagaccac 2580aaagcggaag gcagcgatag aggccctgag agtccggagc tccccacacc aagtgagaat 2640agcatgccac caggcctctc aactcccaca gcctcgcagg agggggccgg tcctgttcca 2700gatcccagcc agcccacccg tcggcagatc cgcctctcca gcccggagcg ccagcggttg 2760tcctccctta accttacccc tgacccggaa atggagcctc cacccaagcc tccccgcagc 2820tgctccgcct tggcccgcca cgccctggag agcagctttg tgggctgggg cctgccagtc 2880cagagccctc aagctcttgt ggccatggag aaggaggaaa aagagagtcc cttctccagt 2940gaagaggaag aagaagatgt gcctttggac tcagatgtgg aacaggccct gcagaccttt 3000gccaagacct caggcaccat gaataactac ccaacatggc gtcggactct gctgcgccgt 3060gcgaaggagg aggagatgaa gaggttctgc aaggcccaga ccatccaacg gcgactaaat 3120gagattgagg ctgccttgag ggagctagag gccgagggcg tgaagctgga gctggccttg 3180aggcgccaga gcagttcccc agaacagcaa aagaaactat gggtaggaca gctgctacag 3240ctcgttgaca agaaaaacag cctggtggct gaggaggccg agctcatgat cacggtgcag 3300gaattgaatc tggaggagaa acagtggcag ctggaccagg agctacgagg ctacatgaac 3360cgggaagaaa acctaaagac agctgctgat cggcaggctg aggaccaggt cctgaggaag 3420ctggtggatt tggtcaacca gagagatgcc ctcatccgct tccaggagga gcgcaggctc 3480agcgagctgg ccttggggac aggggcccag ggctagacga gggtgggccg tctgctttcg 3540ttcccacaaa gaaagcacct caccccagca cagtgccacc cctgttcatc tgggctgcct 3600ggcagagagc cttgctgttt acaattaaaa tgtttctgcc acaaaaaaaa aaaaaaaaaa 3660a 366114651DNAHomo sapiens 14atgtccatag ccctgaagca ggtattcaac aaggacaaga ccttccgacc caagaggaaa 60tttgaacctg gcacacagag gtttgagctg cacaaacggg ctcaggcatc cctcaactcg 120ggtgtggacc tgaaggcggc tgtgcagttg cccagtgggg aggaccagaa tgactgggtg 180gcagtacatg tggtggactt cttcaatcgg atcaacctca tctatggcac catctgtgag 240ttctgcaccg agcggacctg tcctgtgatg tcagggggcc ccaaatatga gtatcggtgg 300caggatgatc tcaagtataa gaagccaaca gcgctgccag ctccccagta catgaacctt 360cttatggatt ggattgaggt tcagatcaac aacgaggaaa tatttccaac atgcgtgggt 420gttcccttcc caaagaactt ccttcagatc tgcaagaaga tcctgtgccg ccttttccgg 480gtctttgtcc acgtctatat ccaccacttc gaccgggtca ttgtgatggg tgcagaggcc 540catgtcaaca cctgctacaa acacttctat tactttgtca cagagatgaa cctcatagac 600cgcaaggagc tagagccttt gaaagaaatg acgagcagga tgtgtcacta a 651152471DNAHomo sapiens 15gcgttacagg ccctttggcg cctgcgtatt cgtgaagtgt gaaaaaagcg cgcctctgtt 60gggacgggaa atcagccttt ctattggtca gggttagaaa ccccgccttt gaggcatttt 120caaccaatgg aagcgcggca ttcttcattt aaactgtcta taaatttctg cctagtcaaa 180gttaagagtg gcgccaggga tttgaaccgc gctgacgaag tttggtgatc catcttccga 240gtatcgccgg gatttcgaat cgcgatgatc atcccctctc tagaggagct ggactccctc 300aagtacagtg acctgcagaa cttagccaag agtctgggtc tccgggccaa cctgagggca 360accaagttgt taaaagcctt gaaaggctac attaaacatg aggcaagaaa aggaaatgag 420aatcaggatg aaagtcaaac ttctgcatcc tcttgtgatg agactgagat acagatcagc 480aaccaggaag aagctgagag acagccactt ggccatgtca ccaaaacaag gagaaggtgc 540aagactgtcc gtgtggaccc tgactcacag cagaatcatt cagagataaa aataagtaat 600cccactgaat tccagaatca tgaaaagcag gaaagccagg atctcagagc tactgcaaaa 660gttccttctc caccagacga gcaccaagaa gctgagaatg ctgtttcctc aggtaacaga 720gattcaaagg taccttcaga aggaaagaaa tctctctaca cagatgagtc atccaaacct 780ggaaaaaata aaagaactgc aatcactact ccaaacttta agaagcttca tgaagctcat 840tttaaggaaa tggagtccat tgatcaatat attgagagaa aaaagaaaca ttttgaagaa 900cacaattcca tgaatgaact gaagcagcag cccatcaata agggaggggt caggactcca 960gtacctccaa gaggaagact ctctgtggct tctactccca tcagccaacg acgctcgcaa 1020ggccggtctt gtggccctgc aagtcagagt accttgggtc tgaaggggtc actcaagcgc 1080tctgctatct ctgcagctaa aacgggtgtc aggttttcag ctgctactaa agataatgag 1140cataagcgtt cactgaccaa gactccagcc agaaagtctg cacatgtgac cgtgtctggg 1200ggcaccccaa aaggcgaggc tgtgcttggg acacacaaat taaagaccat cacggggaat 1260tctgctgctg ttattacccc attcaagttg acaactgagg caacgcagac tccagtctcc 1320aataagaaac cagtgtttga tcttaaagca agtttgtctc gtcccctcaa ctatgaacca 1380cacaaaggaa agctaaaacc atgggggcaa tctaaagaaa ataattatct aaatcaacat 1440gtcaacagaa ttaacttcta caagaaaact tacaaacaac cccatctcca gacaaaggaa 1500gagcaacgga agaaacgcga gcaagaacga aaggagaaga aagcaaaggt tttgggaatg 1560cgaaggggcc tcattttggc tgaagattaa taatttttta acatcttgta aatattcctg 1620tattctcaac ttttttcctt ttgtaaattt tttttttttg ctgtcatccc cactttagtc 1680acgagatctt tttctgctaa ctgttcatag tctgtgtagt gtccatgggt tcttcatgtg 1740ctatgatctc tgaaaagacg ttatcacctt aaagctcaaa ttctttggga tggtttttac 1800ttaagtccat taacaattca ggtttctaac gagacccatc ctaaaattct gtttctagat 1860ttttaatgtc aagttcccaa gttccccctg ctggttctaa tattaacaga actgcagtct 1920tctgctagcc aatagcattt acctgatggc agctagttat gcaagcttca ggagaatttg 1980aacaataaca agaatagggt aagctgggat agaaaggcca cctcttcact ctctatagaa 2040tatagtaacc tttatgaaac ggggccatat agtttggtta tgacatcaat attttaccta 2100ggtgaaattg tttaggctta tgtaccttcg ttcaaatatc ctcatgtaat tgccatctgt 2160cactcactat attcacaaaa ataaaactct acaactcatt ctaacattgc ttacttaaaa 2220gctacatagc cctatcgaaa tgcgaggatt aatgctttaa tgcttttaga gacagggtct 2280cactgtgttg cccaggctgg tctcaaactc caccaaatgt acttcttatt cattttatgg 2340aaaagactag gctttgctta gtatcatgtc catgtttcct tcacctcagt ggagcttctg 2400agttttatac tgctcaagat cgtcataaat aaaatttttt ctcattgtca tagaaaaaaa 2460aaaaaaaaaa a 2471162685DNAHomo sapiens 16gcggaggcgg cctgccgggg tggttcggct tcccgttgcc gcctcgggcg ctgtacccag 60agctcgaaga ggagcagcgc ggccgcgcgg acccggcaag gctgggccgg actcggggct 120cccgagggac gccatgcggg gaggcagggg cgcccctttc tggctgtggc cgctgcccaa 180gctggcgctg ctgcctctgt tgtgggtgct tttccagcgg acgcgtcccc agggcagcgc 240cgggccactg cagtgctacg gagttggacc cttgggcgac ttgaactgct cgtgggagcc 300tcttggggac ctgggagccc cctccgagtt acacctccag agccaaaagt accgttccaa 360caaaacccag actgtggcag tggcagccgg acggagctgg gtggccattc ctcgggaaca 420gctcaccatg tctgacaaac tccttgtctg gggcactaag gcaggccagc ctctctggcc 480ccccgtcttc gtgaacctag aaacccaaat gaagccaaac gccccccggc tgggccctga 540cgtggacttt tccgaggatg accccctgga ggccactgtc cattgggccc cacctacatg 600gccatctcat aaagttctga tctgccagtt ccactaccga agatgtcagg aggcggcctg 660gaccctgctg gaaccggagc tgaagaccat acccctgacc cctgttgaga tccaagattt 720ggagctagcc actggctaca aagtgtatgg ccgctgccgg atggagaaag aagaggattt 780gtggggcgag tggagcccca ttttgtcctt ccagacaccg ccttctgctc caaaagatgt 840gtgggtatca gggaacctct gtgggacgcc tggaggagag gaacctttgc ttctatggaa 900ggccccaggg ccctgtgtgc aggtgagcta caaagtctgg ttctgggttg gaggtcgtga 960gctgagtcca gaaggaatta cctgctgctg ctccctaatt cccagtgggg cggagtgggc 1020cagggtgtcc gctgtcaacg ccacaagctg ggagcctctc accaacctct ctttggtctg 1080cttggattca gcctctgccc cccgtagcgt ggcagtcagc agcatcgctg ggagcacgga 1140gctactggtg acctggcaac cggggcctgg ggaaccactg gagcatgtag tggactgggc 1200tcgagatggg gaccccctgg agaaactcaa ctgggtccgg cttccccctg ggaacctcag 1260tgctctgtta ccagggaatt tcactgtcgg ggtcccctat cgaatcactg tgaccgcagt 1320ctctgcttca ggcttggcct ctgcatcctc cgtctggggg ttcagggagg aattagcacc 1380cctagtgggg ccaacgcttt ggcgactcca agatgcccct ccagggaccc ccgccatagc 1440gtggggagag gtcccaaggc accagcttcg aggccacctc acccactaca ccttgtgtgc 1500acagagtgga accagcccct ccgtctgcat gaatgtgagt ggcaacacac agagtgtcac 1560cctgcctgac cttccttggg gtccctgtga gctgtgggtg acagcatcta ccatcgctgg 1620acagggccct cctggtccca tcctccggct tcatctacca gataacaccc tgaggtggaa 1680agttctgccg ggcatcctat tcttgtgggg cttgttcctg ttggggtgtg gcctgagcct 1740ggccacctct ggaaggtgct accacctaag gcacaaagtg ctgccccgct gggtctggga 1800gaaagttcct gatcctgcca acagcagttc aggccagccc cacatggagc aagtacctga 1860ggcccagccc cttggggact tgcccatcct ggaagtggag gagatggagc ccccgccggt 1920tatggagtcc tcccagcccg cccaggccac cgccccgctt gactctgggt atgagaagca 1980cttcctgccc acacctgagg agctgggcct tctggggccc cccaggccac aggttctggc 2040ctgaaccaca cgtctggctg ggggctgcca gccaggctag agggatgctc atgcaggttg 2100caccccagtc ctggattagc cctcttgatg gatgaagaca ctgaggactc agagaggctg 2160agtcacttac ctgaggacac ccagccaggc agagctggga ttgaaggacc cctatagaga 2220agggcttggc ccccatgggg aagacacgga tggaaggtgg agcaaaggaa aatacatgaa 2280attgagagtg gcagctgcct gccaaaatct gttccgctgt aacagaactg aatttggacc 2340ccagcacagt ggctcacgcc tgtaatccca gcactttggc aggccaaggt ggaaggatca 2400cttagagcta ggagtttgag accagcctgg gcaatatagc aagacccctc actacaaaaa 2460taaaacatca aaaacaaaaa caattagctg ggcatgatgg cacacacctg tagtccgagc 2520cacttgggag gctgaggtgg gaggatcggt tgagcccagg agttcgaagc tgcagggacc 2580tctgattgca ccactgcact ccaggctggg taacagaatg agaccttatc tcaaaaataa 2640acaaactaat aaaaagcaaa aaaaaaaaaa aaaaaaaaaa aaaaa 268517622DNAHomo sapiens 17cataaaccct ggcgcgctcg cgggccggca ctcttctggt ccccacagac tcagagagaa 60cccaccatgg tgctgtctcc tgccgacaag accaacgtca aggccgcctg gggtaaggtc 120ggcgcgcacg ctggcgagta tggtgcggag gccctggaga ggatgttcct gtccttcccc 180accaccaaga cctacttccc gcacttcgac ctgagccacg gctctgccca ggttaagggc 240cacggcaaga aggtggccga cgcgctgacc aacgccgtgg cgcacgtgga cgacatgccc 300aacgcgctgt ccgccctgag cgacctgcac gcgcacaagc ttcgggtgga cccggtcaac 360ttcaagctcc taagccactg cctgctggtg accctggccg cccacctccc cgccgagttc 420acccctgcgg tgcacgcctc cctggacaag ttcctggctt ctgtgagcac cgtgctgacc 480tccaaatacc gttaagctgg agcctcggta gccgttcctc ctgcccgctg ggcctcccaa 540cgggccctcc tcccctcctt gcaccggccc ttcctggtct ttgaataaag tctgagtggg 600cagcaaaaaa aaaaaaaaaa aa 622185199DNAHomo sapiens 18agggacggga agtgggcggg gccggccggc agcagcttgc gggacacgga gccgcgagga 60gacagctgag gcccgcggag accagggggt gaagcctgga gaccctcttg ccctggccta 120gctgcaggcc cccgggatgc tttgggcatg tcctctggag ccccacagaa gagcagccca 180atggccagtg gagctgagga gaccccaggc ttcctggaca cgctcctgca agacttccca 240gccctgctga acccagagga ccctctgcca tggaaggccc cagggacggt gctcagccag 300gaggaggtgg agggcgagct ggctgagctg gccatgggct ttctgggcag caggaaggcc 360ccgccaccac ttgctgctgc tctggcccac gaagcagttt cacagctgct acagacagac 420ctttccgaat tcaggaagtt gcccagggag gaagaagaag aggaggagga cgatgacgag 480gaggaaaagg cccctgtgac cttgctggat gcccaaagcc tggcacagag tttctttaac 540cgcctttggg aagtcgccgg ccagtggcag aagcaggtgc cattggctgc ccgggcctca 600cagcggcagt ggctggtctc catccacgcc atccggaaca ctcgccgcaa gatggaggac 660cggcacgtgt ccctcccttc cttcaaccag ctcttcggct tgtctgaccc tgtgaaccgc 720gcctactttg ctgtgtttga tggtcacgga ggcgtggatg ctgcgaggta cgccgctgtc 780cacgtgcaca ccaacgctgc ccgccagcca gagctgccca cagaccctga gggagccctc 840agagaagcct tccggcgcac cgaccagatg tttctcagga aagccaagcg agagcggctg 900cagagcggca ccacaggtgt gtgtgcgctc attgcaggag cgaccctgca cgtcgcctgg 960ctcggggatt cccaggtcat tttggtacag cagggacagg tggtgaagct gatggagcca 1020cacagaccag aacggcagga tgagaaggcg cgcattgaag cattgggtgg ctttgtgtct 1080cacatggact gctggagagt caacgggacc ctggccgtct ccagagccat cggggatgtc 1140ttccagaagc cctacgtgtc tggggaggcc gatgcagctt cccgggcgct gacgggctcc 1200gaggactacc tgctgcttgc ctgtgatggc ttctttgacg tcgtacccca ccaggaagtt 1260gttggcctgg tccagagcca cctgaccagg cagcagggca gcgggctccg tgtcgccgag 1320gagctggtgg ctgcggcccg ggagcggggc tcccacgaca acatcacggt catggtggtc 1380ttcctcaggg acccccaaga gctgctggag ggcgggaacc agggagaagg ggacccccag 1440gcagaaggga ggaggcagga cttgccctcc agccttccag aacctgagac ccaggctcca 1500ccaagaagct aggtggtttc caggcccctg ccctcccctt cctcccatcc ttgtccttct 1560ctccctcaga agcctcagga cccaacaggt ggcaggcagt ggacagggtg cccgccccac 1620agtgctttcc ccagcacccc agagccagtc gggacacccc ccgcagcccg tcctggtggc 1680tgtggaactg cactgggtgg cgggcagatg gtggaaggca gcttaggaga cctcaccaaa 1740gagaagatgg accggctctt gctcccagct cctattaggc ccggggtggg accagaggtc 1800ataggtgccc aacggcagcc aaaccaaaga cactggtgtg catggggcag catggttgtg 1860cacgtgggac cctggggcgg acccaggagc caaactcttg aagcaccccc tgggtcaggc 1920ccagcagcgg agtggccagc cccagtttcc cattgctcct ctctgcggcc agggccaggt 1980gggttcatat ttacagatat gcccagccag tcctggtcgg ccacaccagt gtcccaaaga 2040ggagagcgca gcagagccag gggtctgttc tgtagcagcc acccccctgc ccccactcca 2100gggcagccat gatgtgcttg ggcccaccag ggccttccgg gctgctctct tccctgagcc 2160cggaaccggc gacgcacatg tgtcttttgt tggtgtgttt gtttttttcc agggaggtct 2220aattccgaag cagtattcca ggttttctct ttgttttatc agtgccaaga tgacctgttg 2280tgtcatataa tttaagcaga gcttagcatt tattttattc tttagaaaac ttaagtattt 2340acttttttaa agctattttt caaggaacct ttttttgcag tattattgaa tttattttct 2400aaatcaggat tgaaacagga acttttccag gtggtgttaa taagccattc aagtgcctta 2460cacagctttg aagaaactag gactgcagtg ggctcggata ggcccattga ggtttttaga 2520aaagcaggat ttgttttgtt agggaggcat gattttggtg agatctttct ggaagagttt 2580tccgcctctt tgtgatgctg aacaccccca aggttctccc ctccccccgc tgcccaggtg 2640actggcagga gctgcgactg ccacgtagtg gtgcctgggc ccgacagcgg ggctctgggc 2700atcccgggtg accttggccc atctgcctgc attcccaccc ccttgggcct ggctggatcc 2760caggcagagg gaccttgctg ctgtgtgatt ggaacattcc caaatatctt gtgaatttgt 2820aatcaaattg gtctcattgg gaaagactct taattaagag gctcaggcaa gcacagaggc 2880agcccgtggg tctctgtctc agtctggagg cagcagggat gctgctggga gtccatggca 2940caggccacag cccctcacct tgccgcggtg gctggcagca cgcctgcctt gctctgcccc 3000atgccctgaa caggcatgag agctccacgt cccctagtgc accctgagag ggggctcaca 3060agtgaccgat cctgggtgcc tcagggagct cactgagggc gtgcaaagtt gaaagtggca 3120aggctggggg agggtgtcgg gtagagggaa gagggcaggg ggctagggga ggactcagag 3180gccatctgca gggccaagcc acaggaaggg ctgagctgga ggtgggcagg gctgctccag 3240gcaggtcaga gcagtgcagg gggaggagag gagaaaggga ggaagctggg ctgtgtggtc 3300cccatgaagg cattcagagt ccacctgcag acagcgagag ccccaggaag gtttgcacag 3360ctgtgcccca agcaccttgg cctcctctca gctcgccgag gaggcacgct agagccgcct 3420tcccggtggg agccctctgt cccacaggga gcggggagcc agctttgctg gggccctacc 3480tgcatgccca gccttacccc tcattctcac agcacagatg aggttgagac catgcagtca 3540atgcattgct taaggtctct tatttacaaa aaaaaacctt aaacatagtc gctgtcattc 3600agacattcag agaatggttg gccacaaaca atgaccaagt attgcttggc ttaacttgaa

3660ggcctgctgt ctccttctgg gggtcaggga cgcagctcca ccctcaccac tagcccaccc 3720tgcccgtggg cataaccttg acgaagagag agaatgattg gcatctgctt ttctcttttc 3780tttgctaata attctgttcc tggctgccga gagtgaagtt tcaccatgtg gaggtttggc 3840tcctatcacc tggtggtctg attcataccc tagcctgagg ctccactgga agatctcgca 3900gcctcagtgt atgggaaacc ctttccccag gcttgtccca gcactgccgc tccccacccc 3960tgagccagga ccccagagga tggccatgcc ccgtgcctgg cagaggtctg gtgccagcac 4020tgggagctgc tccgcccttg ccttggggcc gagggagccc tcgtccaccc ctgcacagca 4080gctgggcaca gaggagcgct cttccatctt gaccaggact gcaccaagaa gcaccaggtg 4140tcttcagcct ccaacctccg gggcgacctt ctcttccagc cacagtccca tgagggcccc 4200tagccaggga cactggtctg taaattgtaa tcctttctcc agcccagctc tccacttgtt 4260ccttgtgtga gctgagcagg cagtgcacct ctgagtgtcc cttttgtaag gcccaggggt 4320tgcactgagt ctgcagaggc cgcgacctcc tagaacgctg tgggtgcagg tgagccggcg 4380tgtcctgggg agatgctgcc agcacacagg ggccctcctg ctgccagcag gttggggtgg 4440ttaagtctta ttagtgtcta ttcttaaaat taagtgggct ggagaagaat ggagctccac 4500atgccagcac cgtatatgga atacaaaagc tggggaagca gggcctgcct tacaggtgtg 4560gctgactctg agcccaggcc tgcaggggtg gagggcagtc cctcagaatc ccagaggcag 4620tcccagcctc agaacccagg ataggaaatg ggtgtgttta gtggggaaag ggacggggtg 4680cagacggcag ggccagtatg gggccccctc cctctcctct cctctcctat ggtgagccca 4740gcgtgggcac cgggccgtct cagccgtgtt cccagggctg ggaggacagc tctggccctt 4800cttaggccta gcctcgtccc aagctaaatg taagccagtt gggctgtgtt aaaggaagca 4860gtgtttttgg ttcgattctg cctctgtagc tcaagggggg cagcccccag agtcctgtgc 4920attctgccaa ggctccatag ctttgccaaa tgcacggagc tctgccattc cggtgcagtg 4980caggccttgc gaagggttta tctgcgttcg tctcggtggg cttctcctgc atgggagttg 5040tgttcctgtg caagggggag ctttgctcca ggacaggatg actgtcttcc ctattcttag 5100ggacaagtcc caagatgcca gaaaggcagt ctcccaagga cccaccatgc agaagtgtca 5160ataaaccaca agttctgaac tctgtaaaaa aaaaaaaaa 5199191767DNAHomo sapiens 19atggcggcgg ccgacggcga cgactcgctg taccccatcg cggtgctcat agacgaactc 60cgcaatgagg acgttcagct tcgcctcaac agcatcaaga agctgtccac catcgccttg 120gcccttgggg ttgaaaggac ccgaagtgag cttctgcctt tccttacaga taccatctat 180gatgaagatg aggtcctcct ggccctggca gaacagctgg gaaccttcac taccctggtg 240ggaggcccag agtacgtgca ctgcctgctg ccaccgctgg agtcgctggc cacagtggag 300gagacagtgg tgcgggacaa ggcagtggag tccttacggg ccatctcaca cgagcactcg 360ccctctgacc tggaggcgca ctttgtgccg ctagtgaagc ggctggcggg cggcgactgg 420ttcacctccc gcacctcggc ctgcggcctc ttctccgtct gctacccccg agtgtccagt 480gctgtgaagg cggaacttcg acagtacttc cggaacctgt gctcagatga cacccccatg 540gtgcggcggg ccgcagcctc caagctgggg gagtttgcca aggtgctgga gctggacaac 600gtcaagagtg agatcatccc catgttctcc aacctggcct ctgacgagca ggactcggtg 660cggctgctgg cggtggaggc gtgcgtgaac atcgcccagc ttctgcccca ggaggatctg 720gaggccctgg tgatgcccac tctgcgccag gccgctgaag acaagtcctg gcgcgtccgc 780tacatggtgg ctgacaagtt cacagagctc cagaaagcag tggggcctga gatcaccaag 840acagacctgg tccctgcctt ccagaacctg atgaaagact gtgaggccga ggtgagggcc 900gcagcctccc acaaggtcaa agagttctgt gaaaacctct cagctgactg tcgggagaat 960gtgatcatgt cccagatctt gccctgcatc aaggagctgg tgtccgatgc caaccaacat 1020gtcaagtctg ccctggcctc agtcatcatg ggtctctctc ccatcttggg caaagacaac 1080accatcgagc acctcttgcc cctcttcctg gctcagctga aggatgagtg ccctgaggta 1140cggctgaaca tcatctctaa cctggactgt gtgaacgagg tgattggcat ccggcagctg 1200tcccagtccc tgctccctgc cattgtggag ctggctgagg acgccaagtg gcgggtgcgg 1260ctggccatca ttgagtacat gcccctcctg gctggacagc tgggagtgga gttctttgat 1320gagaaactta actccttgtg catggcctgg cttgtggatc atgtatatgc catccgcgag 1380gcagccacca gcaacctgaa gaagctagtg gaaaagtttg ggaaggagtg ggcccatgcc 1440acaatcatcc ccaaggtctt ggccatgtcc ggagacccca actacctgca ccgcatgact 1500acgctcttct gcatcaatgt gctgtctgag gtctgtgggc aggacatcac caccaagcac 1560atgctaccca cggttctgcg catggctggg gacccggttg ccaatgtccg cttcaatgtg 1620gccaagtctc tgcagaagat agggcccatc ccggacaaca gcaccttgca gagtgaagtc 1680aagcccatcc tagagaagct gacccaggac caggatgtgg acgtcaaata ctttgcccag 1740gaggctctga ctgttctgtc tctcgcc 17672010640DNAHomo sapiens 20atactcagtc acacaagcca tagcaggaaa cagcgagctt gcagcctcac cgacgagtct 60caactaaaag ggactcccgg agctaggggt ggggactcgg cctcacacag tgagtgccgg 120ctattggact tttgtccagt gacagctgag acaacaagga ccacgggagg aggtgtagga 180gagaagcgcc gcgaacagcg atcgcccagc accaagtccg cttccaggct ttcggtttct 240ttgcctccat cttgggtgcg ccttcccggc gtctagggga gcgaaggctg aggtggcagc 300ggcaggagag tccggccgcg acaggacgaa ctcccccact ggaaaggatt ctgaaagaaa 360tgaagtcagc cctcagaaat gaagttgact gcctgctggc tttctgttga ctggcccgga 420gctgtactgc aagacccttg tgagcttccc tagtctaaga gtaggatgtc tgctgaagtc 480atccatcagg ttgaagaagc acttgataca gatgagaagg agatgctgct ctttttgtgc 540cgggatgttg ctatagatgt ggttccacct aatgtcaggg accttctgga tattttacgg 600gaaagaggta agctgtctgt cggggacttg gctgaactgc tctacagagt gaggcgattt 660gacctgctca aacgtatctt gaagatggac agaaaagctg tggagaccca cctgctcagg 720aaccctcacc ttgtttcgga ctatagagtg ctgatggcag agattggtga ggatttggat 780aaatctgatg tgtcctcatt aattttcctc atgaaggatt acatgggccg aggcaagata 840agcaaggaga agagtttctt ggaccttgtg gttgagttgg agaaactaaa tctggttgcc 900ccagatcaac tggatttatt agaaaaatgc ctaaagaaca tccacagaat agacctgaag 960acaaaaatcc agaagtacaa gcagtctgtt caaggagcag ggacaagtta caggaatgtt 1020ctccaagcag caatccaaaa gagtctcaag gatccttcaa ataacttcag gctccataat 1080gggagaagta aagaacaaag acttaaggaa cagcttggcg ctcaacaaga accagtgaag 1140aaatccattc aggaatcaga agcttttttg cctcagagca tacctgaaga gagatacaag 1200atgaagagca agcccctagg aatctgcctg ataatcgatt gcattggcaa tgagacagag 1260cttcttcgag acaccttcac ttccctgggc tatgaagtcc agaaattctt gcatctcagt 1320atgcatggta tatcccagat tcttggccaa tttgcctgta tgcccgagca ccgagactac 1380gacagctttg tgtgtgtcct ggtgagccga ggaggctccc agagtgtgta tggtgtggat 1440cagactcact cagggctccc cctgcatcac atcaggagga tgttcatggg agattcatgc 1500ccttatctag cagggaagcc aaagatgttt tttattcaga actatgtggt gtcagagggc 1560cagctggagg acagcagcct cttggaggtg gatgggccag cgatgaagaa tgtggaattc 1620aaggctcaga agcgagggct gtgcacagtt caccgagaag ctgacttctt ctggagcctg 1680tgtactgcgg acatgtccct gctggagcag tctcacagct caccatccct gtacctgcag 1740tgcctctccc agaaactgag acaagaaaga aaacgcccac tcctggatct tcacattgaa 1800ctcaatggct acatgtatga ttggaacagc agagtttctg ccaaggagaa atattatgtc 1860tggctgcagc acactctgag aaagaaactt atcctctcct acacataaga aaccaaaagg 1920ctgggcgtag tggctcacac ctgtaatccc agcactttgg gaggccaagg agggcagatc 1980acttcaggtc aggagttcga gaccagcctg gccaacatgg taaacgctgt ccctagtaaa 2040aatacaaaaa ttagctgggt gtgggtgtgg gtacctgtat tcccagttac ttgggaggct 2100gaggtgggag gatcttttga acccaggagt tcagggtcat agcatgctgt gattgtgcct 2160acgaatagcc actgcatacc aacctgggca atatagcaag atcccatctc tttaaaaaaa 2220aaaaaaaagg acaggaacta tcttactcaa tgtattagtc atgtttctct agagggacag 2280aactaatagg atacatgtat ataaaaaggg gagtttatta aggagtattg actcacatga 2340tcacagggtt aggtcccaca ataggtcatc tgcaagcaag gaagccaatt caagtcccaa 2400agctgaagaa cttggagtcc aatgtttgag ggcaggaagc attcagcatg agagaaagat 2460ggaggccaga agactacacc agtctagtct ttccatgttt tgcctgcttt tattctggca 2520gtgctggcag ctgattagat ggtgcccacc cagattgagg atggtctgcc tttcccagtc 2580cactgactca aatgttaaat ctcctttggc agcaccctca cagatgtacc cgggaacact 2640ttgcatcctt ctattcaatc aagttgatac tcagtattaa ccatcacagt ccatttgggc 2700aactatacca aattaccata gaccaggtga cttaaacagc agttatttct cacagttccg 2760gaggctggga aatccaacat ctaagtggta gcatatctgg tgtctggtaa ggcatgcttc 2820cagatcttac cagatgtcag tcttttgatg ttctcacatg gcagaaaaag aggatgcaaa 2880ctctcaagta tatctttaag ggcacaaatt ccattcatga gggctctacc ctcatcacct 2940aattacctcc caaaggcccc accttctgat actgtcactt tggggatact gtctcccctt 3000tgaattctgg ggggaataca aacattcagt ttgtaacaat agccttatga tttagaggtt 3060acttgttcat tcacctagac ctcaaattgc attttacagc tagtcaagta tatctttctc 3120tgatttgata gtgtgaccta aaaggggacc attgtttgaa atatcattag agttgcttat 3180tattattatt attattatta ttattattat tattattatt attgagacag agtttcattc 3240tgctgcccag gctggagtgc agtggcatca tcttggctca ttgcaacctc tgccttctgg 3300gttcaagcga ttctcctgcc tcagcctccc gagtagctgg gattacaggc tcctgccacc 3360acacccggct aatttttgta tttttagtgg agacagggtt tccaccatgt tggccagcgt 3420ggtcttgaac tcctgacctc aggtgattca ccagcctcgg cctcccaaag tgctgggatt 3480acaggtgtga gccactgcac ctggcctatt attattttta aatttttttt ttttaattga 3540tcattcttgg gtgtttctca cagagggtga tttggcaggg tcacaggaca atagtggagg 3600gaaggtcagc agataaacaa gtgaacaaag gtctctggtt ttcctaggca gaggaccctg 3660cggccttccg cagtgtttgt gtccctgggt acttgagatt agggagtggt gatgactctt 3720aaggagcatg ctgccttcaa gcatctgttt aacaaagcac atcttgcact gcccttaatc 3780catttaaccc tgagtggaca cagcacatgt ttcagagagc acagggttgg gggtaaggtc 3840atagatcaac agcatcctaa ggcagaagaa tttttcttag tacagaacaa aatgaagtct 3900cccatgtcta cttctttcta cacagacaca gcaacaatct gatttctcta tcttttcccc 3960acctttcccc cttttctatt ccacaaaacc gccatcgtca tcatggcctg ttctcaatga 4020gctgttgggt acacctccca gacggggtgg cggctgggca gaggggctcc tcacttccca 4080gatggggcgg ccaggcggac gcgcccccca cctccctccc ggacgggata gctggccggg 4140cgggggctga ccccccacct ccctccccga cggggcggct ggccgggcgg gggctgaccc 4200ccacgcctcc ctcccggacg gggcggctgc caggcggagg ggctcctcac ttctcagacg 4260gggtggctgc tgggcggaga cgctcctcac ttcccagaca gggtggctgt cgggcggagg 4320ggctcctcac ttctcagacg gggcagctgc gggcggaggg gctcctcact tctcagacgg 4380ggtggccggg cagagaagct cctcacatcc cagacggggg ggcggggcag aggcgctccc 4440cacatctcag acgatgggcg gccgggcaga gacgctcctc acttcatccc agacggggtg 4500gcggccgggc agaagctgta atctcggcac cctggggggc caaggcaggc ggctgggagg 4560cggaggccgt agccagctga gatcacacca ctgcactcca gcctgggcaa cattgagcac 4620tgagtggacg agactctgcc cgcaatcccg gcacctcggg aggccgaggc tggcagatca 4680ctcgcagtca ggagctggag accagcccgg ccaacacagt gaaaccctgt ctccaccaaa 4740aaaatacgaa aaccagtcag gcgtggcggc gcccgcaatg gcaggcacgc ggcaggccga 4800ggcgggagaa tcaggcaggg aggctgcagt gagccgagat ggcagcagta cagtccagct 4860tcggctcggc atcagaggga gaccgtgggg agagggagaa gagagggagg gggagagggc 4920tatttttaaa attttttaaa attgctgaac aggggtacct ctgggcagtg tgtcagaata 4980ccacttttta aatattttat gatttattta tttttctatt tcttgaggtt ttaactgatg 5040tgtatctgta tgtctatttg tgtatatttt gtcatgatca tgtaacagag tctgaaaagt 5100gtcgaagaga cagttttcag gaacaacaag caattattcc tactttccaa gttattttga 5160tgccatggtg gctcatacct ataatctgag tactttggga ggctgaggtg gactgatcac 5220ttgagcccag gagtttgaga ccagcctggg caacatagca agactccatc tctacaaaaa 5280aagacaaaat ttagctgagc gtggtggcgt gttcctgtag tcccagctac ttgggaggct 5340gaagtgagtg gatcccctga gcccagagag gtcaaggttg tgatgagctg tgatcacacc 5400actgcacttc agcatgggag acagagtgag accctgtttc agaaaaaata aataaataaa 5460accaccagca ccacaaacaa caacaaaaag ttattttgta cttgttttga gcacaggact 5520cctgagggta tctttgcatt taatattaca taggggtgcc agtgggaagt aatgtgtatg 5580cttggcctca tgagctaaaa ccctgtgtta attatgacag aaggaaagtg tgtgagagag 5640atcttaacta cctagcagct ctagctgcca tcttgaacca tgaagatacg ggccacacgt 5700aggggtagct gggtagtgag cagcaagaag ccttgttgga tgagggcacg aaggagcaga 5760atcactggaa tcactgtgtc agccctaatt acctacctct ggacttttat gtgaggggaa 5820aaaaaattga cagtttatat ttatctcaac ctagttaacc caagtgatgc attgttatga 5880gattaaaatg tttggaggcc gggtgcggtg gctcacgcct ataatcccag ccctttggga 5940ggccaaggcg ggcggatcac gaggtcagga gatcaagacc atcctggcta acatgtaaaa 6000ccccgtctct actaaaaata caaaaaatta gccaggcgtt gtggcggtcg cctgtagtcc 6060ctgctatttg ggaggccgag gcaagagaac ggcatgaacc tgggaggtgg agcttgcagc 6120gagctgagat cttgccactg cactccagcc tgggcgacag tgcgagactc tgtctcaaaa 6180ataaataaat aaataaataa taaataaaat gtttggaatg ttggcttcat ccctgggatg 6240caaggctggt tcaacatacg caaatcaaga aacataattc atcacataaa cagaactaaa 6300gacaaaaacc acatgattat ctcaatagat acagaaaagg ccttcaataa aattcaacgt 6360tgcttcatgt taaaaactct caataaacta ggtattgatg gaaaatatct caaaataata 6420accatttatg acaaacccac agccattatc atactgaatg ggcaaaagct ggaagcattc 6480cccttgaaaa ctggcacaag acagggatgc cgtctcacca ctcctattta acatagtatt 6540ggaagttctg gccaagaaaa tcaggcaaga gaaacaaata aggggtattc aaataggaaa 6600agaggaagta aaactgtgtt tgcagatgac atgatactat atctagaaaa ccccattatc 6660tccacccaaa agttccttaa gctgataagc aacttcagca aagtctcagg atacaaaatc 6720aatgtgcaga aatcacaagc attctataca ccaacaatac acaagcagag agccaaatca 6780tgaatgaact cccattcaca gttgctagaa agagaataaa atacctagga atacagctaa 6840taagatgtga aggatctctt caaggagaac tacaaaccac tgctcaagga aataagagag 6900gacacaaatg aaaaaacatt ccattctcgt ggataggaag aatcaatatc atgaaaatgg 6960ccatactacc caaagtaatt tataggttca ttgctattcc cattaaacta ctattgacat 7020tcttcacaga attagaaaaa aactacttta aaattcaaat ggaaccaaaa aagagcccgt 7080ataaccaaga caacaataag caaaaagaac aaagctggaa gcatcacact acccaacttc 7140aaagtatact gcaaggctac agtagccaaa atggcatggt actggtacaa aaacagacac 7200atagaccaat ggaacagaat agagaccaga gaaagaagac cacacatcta cagccatctg 7260atcatcgaca aacctgacaa aaacaagcaa tggggaaaag attccctatt taataaatgg 7320tgctgggaaa actggctagc catatgcaga aaattgaaac tgaccccttc cttacacctt 7380atacaaaaat taactcaaga ttaaagactt aatgtaaaac ctaaaactat aaaaacccta 7440gaagaaaatc tatttaatac cattcaagac ataggcacaa gcaaaggttt catgacaaaa 7500acatcaaaag caattgcaac aaaagcaaaa attacaaatg ggatctaatt aaactaaaga 7560gctcctgcac agcaaaagaa actatcatta gagtgaacag gcaacctaca gaatgggaga 7620acatttttgc aatctatcca tctgacaaag gtctaatatc cagaacctac aaggaactta 7680aaacaaattt acaaggaaaa aaacaacccc atcaaaaagt ggacaaagga catgaacaga 7740cacttctcaa aagaagacat ttatgtggcc aacaaacata taaaaaaaag ctcaacctta 7800ctgatcatta gagaaatgca aaggagaacc acaatgagat accatctcat gccggtcaga 7860atggtgatta ttaaaaagtc aaaaaacaac agatgctggc gaggctgtgg agaagtagga 7920acacttttac attgttggtg ggaatgtaaa ttagttcaac cgttgtggaa gtgtgtgtgg 7980ctattcctca aagatctaga actagaaata ctatttgtcc cagcaatccc attactgggt 8040atatacccaa aggaatataa accattttat tataaagata catgcacatt tttgttcatt 8100gcagcactct tcacaatagc aaagacacaa tagcaaatgc ccatcaaaga tagactggat 8160aaagaaaatg tggtacatat acaccatgga atactgtgca gtgcagccat tacagctttt 8220ggtgatacag tgaatcagat ttttcattaa ttcttttaat tggttattac tgaacgtgaa 8280aaagtaatgt ttgtattgaa atcttgagtc tggccatgtt tctattttaa attcataaag 8340aattctaaca agaggaattc caagaatgtc ataaatggat gtttctccat ggatgaagga 8400actgttttat tcacttgctg ataattcagc ctaatccagt ttgacatcat atagataagt 8460agttgaatta tggatttaaa atacatatca ttttctaact ccaaaggtaa tacttattta 8520aatggttttg aaaatataga aaggcacaat ttctttttaa atctgttatt ctccaccacc 8580actcaatctg tctatcatct atctctccat tcattcttcc atttgtttat atctgttaat 8640ctttgtatgt gttcatgtat agcttttaca tgattggaat cataatgcat attccatttt 8700gaagtctgct tttttttaca caaaaatatg ttgtgaatat tttcctatat tatgaaatat 8760cattagctga gcttttagaa ttgactgcat gttttggtac catttagata tagtttaaga 8820tacttagaag ttatgtggct ttgccactat ggatgaatct tatttactca atattaatta 8880cttacaaata acctcaccta aacactactc agccataaaa aggaatgaat taatgacatt 8940cacagcaacc tggagactat tactctaaag gaagtaactg aggaatggaa aaccaaacat 9000tgtatgttct cactcataag tgggagataa gctatgagga tgcaaaggca taagaaggat 9060acaatggact ttggggactt aggggaaagg gtgggagggg ggtgaaggat aaaagaatac 9120aaattgggtt cagtgtatac tgctcaggtg atgggtgcac cagaatctca caagtaacca 9180cttaattact tacgcatgta accagatacc acctgttccc caaacaccta tggaaataat 9240tttgtttttt tttttaaaaa aggaatgaga tcatgtcctt tgcagggaca tggatgaagc 9300tggaagccat tatcctcagc aaactaacag aggagcagga aaccaaacac cacatgttct 9360cacttgtaag cggaagctga acaatgagaa cacacggaca cagggatgag atcaacacac 9420actggggcct gatgcagggg ccgtagcggg gagagcatca ggataactag ctaatgcatg 9480tggggcttaa tacctaggtg ataggttgat aggtgcagca aaccaccatg ggacacgttt 9540acctatgtaa caaacccgca catcctgcac ttgtatccag aacttaaaat attttaaaaa 9600tctttagaga atacaaaaaa aaaaaaaaag attcttcaat gcatacacaa taaaattgca 9660gttcagtcaa acattggaag tctttctctg actgtctagt tggtatcttc attttcagct 9720tcttcaagat cccactccaa acactgttag ctcagccaaa ttgaacagct catatctcct 9780acctctggat ctttggttct ggtgattgta tatttctgga ccatctggaa ccccagcata 9840tcaccctacc ccacatctcc acatccccaa aatataacca tacttcaagg gcagttcaaa 9900taccatctcc ttctatcctc catgaagtca gttatctctt ccattggaat tatcgccccc 9960tctcctgaac agtactattt cgtgtgaatc tcctccaagc cttcttttca ttttatatct 10020catgctgtaa ttcttggaaa gtatgctgta gctcaagtgc agaattctca tcagttttat 10080ctttatatct ctcctaaaca ctttacctga tgaagagcct ggcatacaca taaatatata 10140ttgaatgaat cagtgatgga ttgaaaagag aaatgatgga tctcctaaat tttaactttt 10200ataaaatatt ttgatacatt catgacctta ctttagcaag caatgaacgt gatgtaaact 10260attgttgata tagtttttat attggaagtg taagtagttt gtggcatggg attgtgacat 10320atcctaggtt tcctcatctt ctttttattg aaatgtaatt cacaagccat aaaatttgcc 10380cctttaaagt aaatgatgca gtggatttta gtatatttac agagttgtgc aatcatcacc 10440actatctaat tccagaacat ttccatctac ctagaaactc cataccagtg agctgccact 10500ctaatcctcc tcttccccca gcctctagaa acaataatcc attttctgtc tctatgattt 10560gcctgttcta gatattttat aaaaataaac atgtggcctt tcgtgtctga cttccttcac 10620ttaaaaaaaa aaaaaaaaaa 10640211939DNAHomo sapiens 21cgcctccgcc ttcggaggct gacgcgcccg ggcgccgttc caggcctgtg cagggcggat 60cggcagccgc ctggcggcga tccagggcgg tgcggggcct gggcgggagc cgggaggcgc 120ggccggcatg gaggcgctgc tgctgggcgc ggggttgctg ctgggcgctt acgtgcttgt 180ctactacaac ctggtgaagg ccccgccgtg cggcggcatg ggcaacctgc ggggccgcac 240ggccgtggtc acgggcgcca acagcggcat cggaaagatg acggcgctgg agctggcgcg 300ccggggagcg cgcgtggtgc tggcctgccg cagccaggag cgcggggagg cggctgcctt 360cgacctccgc caggagagtg ggaacaatga ggtcatcttc atggccttgg acttggccag 420tctggcctcg gtgcgggcct ttgccactgc ctttctgagc tctgagccac ggttggacat 480cctcatccac aatgccggta tcagttcctg tggccggacc cgtgaggcgt ttaacctgct 540gcttcgggtg aaccatatcg gtccctttct gctgacacat ctgctgctgc cttgcctgaa 600ggcatgtgcc cctagccgcg tggtggtggt agcctcagct gcccactgtc ggggacgtct 660tgacttcaaa cgcctggacc gcccagtggt gggctggcgg caggagctgc gggcatatgc 720tgacactaag ctggctaatg tactgtttgc ccgggagctc gccaaccagc ttgaggccac 780tggcgtcacc tgctatgcag cccacccagg gcctgtgaac tcggagctgt tcctgcgcca 840tgttcctgga tggctgcgcc cacttttgcg cccattggct tggctggtgc tccgggcacc 900aagagggggt gcccagacac ccctgtattg tgctctacaa gagggcatcg agcccctcag

960tgggagatat tttgccaact gccatgtgga agaggtgcct ccagctgccc gagacgaccg 1020ggcagcccat cggctatggg aggccagcaa gaggctggca gggcttgggc ctggggagga 1080tgctgaaccc gatgaagacc cccagtctga ggactcagag gccccatctt ctctaagcac 1140cccccaccct gaggagccca cagtttctca accttacccc agccctcaga gctcaccaga 1200tttgtctaag atgacgcacc gaattcaggc taaagttgag cctgagatcc agctctccta 1260accctcaggc caggatgctt gccatggcac ttcatggtcc ttgaaaacct cggatgtgtg 1320cgaggccatg ccctggacac tgacgggttt gtgatcttga cctccgtggt tactttctgg 1380ggccccaagc tgtgccctgg acatctcttt tcctggttga aggaataatg ggtgattatt 1440tcttcctgag agtgacagta accccagatg gagagatagg ggtatgctag acactgtgct 1500tctcggaaat ttggatgtag tattttcagg ccccaccctt attgattctg atcagctctg 1560gagcagaggc agggagtttg caatgtgatg cactgccaac attgagaatt agtgaactga 1620tccctttgca accgtctagc taggtagtta aattaccccc atgttaatga agcggaatta 1680ggctcccgag ctaagggact cgcctagggt ctcacagtga gtaggaggag ggcctgggat 1740ctgaacccaa gggtctgagg ccagggccga ctgccgtaag atgggtgctg agaagtgagt 1800cagggcaggg cagctggtat cgaggtgccc catgggagta aggggacgcc ttccgggcgg 1860atgcagggct ggggtcatct gtatctgaag cccctcggaa taaagcgcgt tgaccgccga 1920aaaaaaaaaa aaaaaaaaa 1939221840DNAHomo sapiens 22gggttcccag gccgactctc cttgtggttg gctgaggctg gaggtggacg ggacttttgg 60agggtcgctc gcgtctgttc gcagagctgt gggcggagtt gaggccttgg aggctgagat 120gtggttctgc gcgtgtgcgg acggctgtct gttaactccg cggtcagttc ccggactggt 180ggctggtctg cagggttgac ctgcgcaatg cagaggctgc aggtagtgct gggccacctg 240aggggtccgg ccgattccgg ctggatgccg caggccgcgc cttgcctgag cggtgccccg 300caggcctcgg ccgcggacgt ggtggtggtg cacgggcggc gcacggccat ctgccgggcg 360ggccgcggcg gcttcaagga caccaccccc gacgagcttc tctcggcagt catgaccgcg 420gttctcaagg acgtgaatct gaggccggaa cagctggggg acatctgtgt cggaaatgtg 480ctgcagcctg gggccggggc aatcatggcc cgaatcgccc agtttctgag tgacatcccg 540gagactgtgc ctttgtccac tgtcaataga cagtgttcgt cggggctaca ggcagtggcc 600agcatagcag gtggcatcag aaatgggtct tatgacattg gcatggcctg tggggtggag 660tccatgtccc tggctgacag agggaaccct ggaaatatta cttcgcgctt gatggagaag 720gagaaggcca gagattgcct gattcctatg gggataacct ctgagaatgt ggctgagcgg 780tttggcattt cacgggagaa gcaggatacc tttgccctgg cttcccagca gaaggcagca 840agagcccaga gcaagggctg tttccaagct gagattgtgc ctgtgaccac cacggtccat 900gatgacaagg gcaccaagag gagcatcact gtgacccagg atgagggtat ccgccccagc 960accaccatgg agggcctggc caaactgaag cctgccttca agaaagatgg ttctaccaca 1020gctggaaact ctagccaggt gagtgatggg gcagctgcca tcctgctggc ccggaggtcc 1080aaggcagaag agttgggcct tcccatcctt ggggtcctga ggtcttatgc agtggttggg 1140gtcccacctg acatcatggg cattggacct gcctatgcca tcccagtagc tttgcaaaaa 1200gcagggctga cagtgagtga cgtggacatc ttcgagatca atgaggcctt tgcaagccag 1260gctgcctact gtgtggagaa gctacgactc ccccctgaga aggtgaaccc cctggggggt 1320gcagtggcct tagggcaccc actgggctgc actggggcac gacaggtcat cacgctgctc 1380aatgagctga agcgccgtgg gaagagggca tacggagtgg tgtccatgtg catcgggact 1440ggaatgggag ccgctgccgt ctttgaatac cctgggaact gagtgaggtc ccaggctgga 1500ggcgctacgc agacagtcct gctgctctag cagcaaggca gtaacaccac aaaagcaaaa 1560ccacatggga aaactcagca ctggtggtgg tggcagtgga cagatcaagg cacttcaact 1620catttggaaa atgtgaacac tgatgacatg gtataggagt gggtggggtg ttgagccacc 1680catcagaccc tctttagctg tgcaagataa aagcagcctg ggtcacccag gccacaaggc 1740catggttaat tcttaaggca aggcaaatcc atggatgaga agtgcaatgg gcatagtaaa 1800agtgcatgaa tttatcttaa aaaaaaaaaa aaaaaaaaaa 1840233407DNAHomo sapiens 23caggttgaaa tggctgatga catcactggt tcccgggagc ggtagagctg gagccggagc 60caagggagtc caggctgccg ggggctgcag acatggaggg ccagagcagc aggggcagca 120ggaggccagg gacccgggct ggcctgggtt ccctgcccat gccccagggt gttgcccaaa 180ctggggcacc ctccaaggtg gactcaagtt ttcagctccc agcaaagaag aacgcagccc 240taggaccctc ggaaccaagg ttggctctgg cacctgtagg gccacgggca gctatgtcag 300cttcctcgga aggaccgagg ctggctctgg catctccccg accaatcctg gctccactgt 360gtacccctga agggcagaaa acagctactg cccaccgcag ctccagcctg gccccaacat 420ctgtgggcca gctggtgatg tctgcctcag ctggaccaaa gcctccccca gcgaccacag 480gctcagttct ggctccgacg tccctggggc tggtgatgcc tgcctcagca gggccaagat 540ctcccccagt caccctgggg cccaatctgg ccccaacctc cagagaccag aagcaggagc 600cacctgcctc cgtgggaccc aagccaacac tggcagcctc tggcctgagc ctggccctgg 660cttctgagga gcagccccca gaactcccct ccaccccttc cccggtgccc agtccagttc 720tgtctccaac tcaggaacag gccctggctc cagcatccac ggcatcaggc gcagcctctg 780tgggacagac atcagctaga aagagggatg ccccagcccc tagacctctc cctgcttctg 840aggggcatct ccagcctcca gctcagacat ctggtcctac aggctcccca ccctgcatcc 900aaacctcccc agaccctcgg ctctccccct ccttccgagc ccggcctgag gccctccaca 960gcagccctga ggatcctgtt ttgccacggc caccccagac cttgcccttg gatgtgggcc 1020agggtccttc agagcctggc actcactccc ctggacttct gtcccccacc ttccggcctg 1080gggccccctc aggccagact gtgcccccac ctctgcccaa gccaccccga tcacccagcc 1140gttccccaag ccactccccg aatcgctctc cctgtgttcc cccagcccct gacatggccc 1200tcccaaggct tggcacacag agtacagggc ctggcaggtg cctgagcccc aaccttcagg 1260cccaagaagc cccagcccca gtcaccacct cctcttctac atccaccctg tcatcctccc 1320cttggtcagc tcagcctacc tggaagagcg accccggctt ccggatcact gtggtcacat 1380ggaacgtggg cactgccatg cccccagacg atgtcacatc cctcctccac ctgggcggtg 1440gtgacgacag cgacggcgca gacatgatcg ccatagggtt gcaggaagtg aactccatgc 1500tcaacaagcg actcaaggac gccctcttca cggaccagtg gagtgagctg ttcatggatg 1560cgctagggcc cttcaacttc gtgctggtga gttcggtgag gatgcagggt gtcatcctgc 1620tgctgttcgc caagtactac cacctgccct tcctgcgaga cgtgcagacc gactgcacgc 1680gcactggcct gggcggctac tggggtaaca agggtggcgt gagcgtgcgc ctggcggcct 1740tcgggcacat gctctgcttc ctgaactgcc acttgcctgc gcatatggac aaggcggagc 1800agcgcaaaga caacttccag accatcctca gcctccagca gttccaaggg ccgggcgcac 1860agggcatcct ggatcatgac ctcgtgttct ggttcgggga cctgaacttc cgcattgaga 1920gctatgacct gcactttgtc aagtttgcca tcgacagtga ccagctccat cagctctggg 1980agaaggacca gctcaacatg gccaagaaca cctggcccat tctgaagggc tttcaggagg 2040ggcccctcaa cttcgctccc accttcaagt ttgatgtggg taccaacaaa tacgatacca 2100gtgccaagaa acggaagcca gcttggacag accgtatcct atggaaggtc aaggctccag 2160gtgggggtcc cagcccctca ggacggaaga gccaccgact ccaggtgacg cagcacagct 2220accgcagcca catggaatac acagtcagcg accacaagcc tgtggctgcc cagttcctcc 2280tgcagtttgc cttcagggac gacatgccac tggtgcggct ggaggtggca gatgagtggg 2340tgcggcccga gcaggcggtg gtgaggtacc gcatggaaac agtgttcgcc cgcagctcct 2400gggactggat cggcttatac cgggtgggtt tccgccattg caaggactat gtggcttatg 2460tctgggccaa acatgaagat gtggatggga atacctacca ggtaacattc agtgaggaat 2520cactgcccaa gggccatgga gacttcatcc tgggctacta tagtcacaac cacagcatcc 2580tcatcggcat cactgaaccc ttccagatct cgctgccttc ctcggagttg gccagcagca 2640gcacagacag ctcaggcacc agctcagagg gagaggatga cagcacactg gagctccttg 2700cacccaagtc ccgcagcccc agtcctggca agtccaagcg acaccgcagc cgcagcccgg 2760gactggccag gttccctggg cttgccctac ggccctcatc ccgtgaacgc cgtggtgcca 2820gccgtagccc ctcaccccag agccgccgcc tgtcccgagt ggctcctgac aggagcagta 2880atggcagcag ccggggcagt agtgaagagg ggccctctgg gttgcctggc ccctgggcct 2940tcccaccagc tgtgcctcga agcctgggcc tgttgcccgc cttgcgccta gagactgtag 3000accctggtgg tggtggctcc tggggacctg atcgggaggc cctggcgccc aacagcctgt 3060ctcctagtcc ccagggccat cgggggctgg aggaaggggg cctggggccc tgagggtggg 3120gtaggcagat gggccaaggt gaccaccatt ctgcctcaat cttttgcaag cccacctgcc 3180tctctcctgc tgctcctcca gctgtatctg cacctgcctc tctgtcctgg ccaggggtgg 3240acaactgggg tcccccaaaa ctcagtcctg gcacctcaac tgtgacaatc agcaaagccc 3300cacccaggcc cccatctggg atgatgggag agctctggca gatgtcccaa tcctggaggt 3360catccattag gaattaaatt ctccagcctc aaaaaaaaaa aaaaaaa 3407241146DNAHomo sapiens 24ttttgcgaac ggcgagcagc ggcggcggcg cggagagacg cagcggaggt tttcctggtt 60tcggacccca gcggccggat ggtgaaatcc tccctgcagc ggatcctcaa tagccactgc 120ttcgccagag agaaggaagg ggataaaccc agcgccacca tccacgccag ccgcaccatg 180ccgctcctaa gcctgcacag ccgcggcggc agcagcagtg agagttccag ggtctccctc 240cactgctgta gtaacccggg tccggggcct cggtggtgct cctgatgccc ctcacccacc 300cctgaagatc ccaggtgggc gagggaatag tcagagggat cacaatcttt cagctaactt 360attctactcc gatgatcggc tgaatgtaac agaggaacta acgtccaacg acaagacgag 420gattctcaac gtccagtcca ggctcacaga cgccaaacgc attaactggc gaacagtgct 480gagtggcggc agcctctaca tcgagatccc gggcggcgcg ctgcccgagg ggagcaagga 540cagctttgca gttctcctgg agttcgctga ggagcagctg cgagccgacc atgtcttcat 600ttgcttccac aagaaccgcg aggacagagc cgccttgctc cgaaccttca gctttttggg 660ctttgagatt gtgagaccgg ggcatcccct tgtccccaag agacccgacg cttgcttcat 720ggcctacacg ttcgagagag agtcttcggg agaggaggag gagtagggcc gcctcggggc 780tgggcatccg gcccctgggg ccaccccttg tcagccgggt gggtaggaac cgtagactcg 840ctcatctcgc ctgggtttgt ccgcatgttg taatcgtgca aataaacgct cactccgaat 900tagcggtgta tttcttgaag tttaatattg tgtttgtgat actgaagtat ttgctttaat 960tctaaataaa aatttatatt ttactttttt attgctggtt taagatgatt cagattatcc 1020ttgtactttg aggagaagtt tcttatttgg agtcttttgg aaacagtctt agtcttttaa 1080cttggaaaga tgaggtatta atcccctcca ttgctctcca aaagccaata aagtgattac 1140acccga 1146251215DNAHomo sapiens 25gccaggaagg cttgcaggtt ctgctgtttg gttgctgaag ggggtcagtg tgtgtatgtg 60tcatggaggt gggcagggaa ggggagggct gtgcgtgggg gagaggatat atatgctggt 120gtggctgaga aagcggaacc gagcctcgca tccatcggag ggagccgggg actgacagct 180ctcagcacct gcttcctgct cctgcaccat gaaagtcctg ctttgtgacc tgctgctgct 240cagtctcttc tccagtgtgt tcagcagttg tcagagggac tgtctcacat gccaggagaa 300gctccaccca gccctggaca gcttcgacct ggaggtgtgc atcctcgagt gtgaagagaa 360ggtcttcccc agccccctct ggactccatg caccaaggtc atggccagga gctcttggca 420gctcagccct gccgccccag agcatgtggc ggctgctctc taccagccga gagcttcgga 480gatgcagcat ctgcggcgaa tgccccgagt ccggagcttg ttccaggagc aggaagagcc 540cgagcctggc atggaggagg ctggtgagat ggagcagaag cagctgcaga agagatttgg 600gggcttcacc ggggcccgga agtcggccag gaagttggcc aatcagaagc ggttcagtga 660gtttatgagg caatacttgg tcctgagcat gcagtccagc cagcgccggc gcaccctgca 720ccagaatggt aatgtgtagc cggaaggggc gctcctccca gctgtaccgg ccactgcaac 780ccatgagcgt ccaggtgatc ccccaaacag catgtgctca gccccagacc tgccgcctgg 840gaatcaggat tccttcttcc ccaaggcact gagcgcctgc agatcccgca ggcttcgttt 900gcctccagaa ccttcccgtc tgattgttcc tccccagccc cctggcatgt ttcaccacaa 960ccctgttgct acatcagagt gtatttttgt aattcctcta gctaccattt caatagcccc 1020atctctcctg ctcacccgcc tcttgcccct tctaggggca ggtgaaagga ataggaaatt 1080gaacctgggg ttttgacttg ccactgccat aacttgtttg taaaagagct gttctttttg 1140actgattgtt ttaaacaacg atttctccat taaacttcta ctgagcaaat ggttaataaa 1200aaaaaaaaaa aaaaa 1215264264DNAHomo sapiens 26agagcgctgc ggccgcggcg gtgcagcaga ggcgcctcgg gcaggaggag ggcggcttct 60gcgagggcag cctgaggtat taaaaagtgt cagcaaactg cattgaataa cagacatcct 120aagaggggat attttccacc tctataatga agaaaagcag gagtgtgatg acggtgatgg 180ctgatgataa tgttaaagat tattttgaat gtagcttgag taaatcctac agttcttcca 240gtaacacact tgggatcgac ctctggagag ggagaaggtg ttgctcagga aacttacagt 300taccaccact gtctcaaaga cagagtgaaa gggcaaggac tcctgaggga gatggtattt 360ccaggccgac cacactgcct ttgacaacgc ttccaagcat tgctattaca actgtaagcc 420aggagtgctt tgatgtggaa aatggccctt ccccaggtcg gagtccactg gatccccagg 480ccagctcttc cgctgggctg gtacttcacg ccacctttcc tgggcacagc cagcgcagag 540agtcatttct ctacagatca gacagcgact atgacttgtc accaaaggcg atgtcgagaa 600actcttctct tccaagcgag caacacggcg atgacttgat tgtaactcct tttgcccagg 660tccttgccag cttgcgaagt gtgagaaaca acttcactat actgacaaac cttcatggta 720catctaacaa gaggtcccca gctgctagtc agcctcctgt ctccagagtc aacccacaag 780aagaatctta tcaaaaatta gcaatggaaa cgctggagga attagactgg tgtttagacc 840agctagagac catacagacc taccggtctg tcagtgagat ggcttctaac aagttcaaaa 900gaatgctgaa ccgggagctg acacacctct cagagatgag ccgatcaggg aaccaggtgt 960ctgaatacat ttcaaatact ttcttagaca agcagaatga tgtggagatc ccatctccta 1020cccagaaaga cagggagaaa aagaaaaagc agcagctcat gacccagata agtggagtga 1080agaaattaat gcatagttca agcctaaaca atacaagcat ctcacgcttt ggagtcaaca 1140ctgaaaatga agatcacctg gccaaggagc tggaagacct gaacaaatgg ggtcttaaca 1200tctttaatgt ggctggatat tctcacaata gacccctaac atgcatcatg tatgctatat 1260tccaggaaag agacctccta aagacattca gaatctcatc tgacacattt ataacctaca 1320tgatgacttt agaagaccat taccattctg acgtggcata tcacaacagc ctgcacgctg 1380ctgatgtagc ccagtcgacc catgttctcc tttctacacc agcattagac gctgtcttca 1440cagatttgga gatcctggct gccatttttg cagctgccat ccatgacgtt gatcatcctg 1500gagtctccaa tcagtttctc atcaacacaa attcagaact tgctttgatg tataatgatg 1560aatctgtgtt ggaaaatcat caccttgctg tgggtttcaa actgctgcaa gaagaacact 1620gtgacatctt catgaatctc accaagaagc agcgtcagac actcaggaag atggttattg 1680acatggtgtt agcaactgat atgtctaaac atatgagcct gctggcagac ctgaagacaa 1740tggtagaaac gaagaaagtt acaagttcag gcgttcttct cctagacaac tataccgatc 1800gcattcaggt ccttcgcaac atggtacact gtgcagacct gagcaacccc accaagtcct 1860tggaattgta tcggcaatgg acagaccgca tcatggagga atttttccag cagggagaca 1920aagagcggga gaggggaatg gaaattagcc caatgtgtga taaacacaca gcttctgtgg 1980aaaaatccca ggttggtttc atcgactaca ttgtccatcc attgtgggag acatgggcag 2040atttggtaca gcctgatgct caggacattc tcgatacctt agaagataac aggaactggt 2100atcagagcat gatacctcaa agtccctcac caccactgga cgagcagaac agggactgcc 2160agggtctgat ggagaagttt cagtttgaac tgactctcga tgaggaagat tctgaaggac 2220ctgagaagga gggagaggga cacagctatt tcagcagcac aaagacgctt tgtgtgattg 2280atccagaaaa cagagattcc ctgggagaga ctgacataga cattgcaaca gaagacaagt 2340cccccgtgga tacataatcc ccctctccct gtggagatga acattctatc cttgatgagc 2400atgccagcta tgtggtaggg ccagcccacc atgggggcca agacctgcac aggacaaggg 2460ccacctggcc tttcagttac ttgagtttgg agtcagaaag caagaccagg aagcaaatag 2520cagctcagga aatcccacgg ttgacttgcc ttgatggcaa gcttggtgga gagggctgaa 2580gctgttgctg ggggccgatt ctgatcaaga cacatggctt gaaaatggaa gacacaaaac 2640tgagagatca ttctgcacta agtttcggga acttatcccc gacagtgact gaactcactg 2700actaataact tcatttatga atcttctcac ttgtcccttt gtctgccaac ctgtgtgcct 2760tttttgtaaa acattttcat gtctttaaaa tgcctgttga atacctggag tttagtatca 2820acttctacac agataagctt tcaaagttga caaacttttt tgactctttc tggaaaaggg 2880aaagaaaata gtcttccttc tttcttgggc aatatccttc actttactac agttactttt 2940gcaaacagac agaaaggata cacttctaac cacattttac ttccttcccc tgttgtccag 3000tccaactcca cagtcactct taaaacttct ctctgtttgc ctgcctccaa cagtactttt 3060aactttttgc tgtaaacaga ataaaattga acaaattagg gggtagaaag gagcagtggt 3120gtcgttcacc gtgagagtct gcatagaact cagcagtgtg ccctgctgtg tcttggaccc 3180tgccccccac aggagttgta cagtccctgg ccctgttccc tacctcctct cttcaccccg 3240ttaggctgtt ttcaatgtaa tgctgccgtc cttctcttgc actgccttct gcgctaacac 3300ctccattcct gtttataacc gtgtatttat tacttaatgt atataatgta atgttttgta 3360agttattaat ttatatatct aacattgcct gccaatggtg gtgttaaatt tgtgtagaaa 3420actctgccta agagttacga ctttttcttg taatgttttg tattgtgtat tatataaccc 3480aaacgtcact tagtagagac atatggcccc cttggcagag aggacagggg tgggcttttg 3540ttcaaagggt ctgccctttc cctgcctgag ttgctacttc tgcacaaccc ctttatgaac 3600cagttttgga aacaatattc tcacattaga tactaaatgg tttatactga gcttttactt 3660ttgtatagct tgataggggc agggggcaat gggatgtagt ttttacccag gttctatcca 3720aatctatgtg ggcatgagtt gggttataac tggatcctac tatcattgtg gctttggttc 3780aaaaggaaac actacatttg ctcacagatg attcttctga atgctcccga actactgact 3840ttgaagaggt agcctcctgc ctgccattaa gcaggaatgt catgttccag ttcattacaa 3900aagaaaacaa taaaacaatg tgaattttta taataaaatg tgaactgatg tagcaaatta 3960cgcaaatgtg aagcctcttc tgataacact tgttaggcct cttactgatg tcagtttcag 4020tttgtaaaat atgtttcatg ctttcagttc agcattgtga ctcagtaatt acagaaaatg 4080gcacaaatgt gcatgaccaa tgtatgtcta tgaacactgc attgtttcag gtggacattt 4140tatcattttc aaatgtttct cacaatgtat gttatagtat tattattata tattgtgttc 4200aaatgcattc taaagagact tttatatgag gtgaataaag aaaagcatga ttagattaaa 4260aaaa 4264272759DNAHomo sapiens 27gctcaggccc cgcccctgcc gccggaatcc tgaagcccaa ggctgcccgg gggcggtccg 60gcggcgccgg cgatggggca taaaaccact ggccacctgc cgggctgctc ctgcgtgcgc 120tgccgtcccg gatccaccgt gcctctgcgg cctgcgtgcc cggagtcccc gcctgtgtcg 180tctctgtcgc cgtccccgtc tcctgccagg cgcggagccc tgcgagccgc gggtgggccc 240caggcgcgca gacatgggct gctccgccaa agcgcgctgg gctgccgggg cgctgggcgt 300cgcggggcta ctgtgcgctg tgctgggcgc tgtcatgatc gtgatggtgc cgtcgctcat 360caagcagcag gtccttaaga acgtgcgcat cgaccccagt agcctgtcct tcaacatgtg 420gaaggagatc cctatcccct tctatctctc cgtctacttc tttgacgtca tgaaccccag 480cgagatcctg aagggcgaga agccgcaggt gcgggagcgc gggccctacg tgtacaggga 540gttcaggcac aaaagcaaca tcaccttcaa caacaacgac accgtgtcct tcctcgagta 600ccgcaccttc cagttccagc cctccaagtc ccacggctcg gagagcgact acatcgtcat 660gcccaacatc ctggtcttgg gtgcggcggt gatgatggag aataagccca tgaccctgaa 720gctcatcatg accttggcat tcaccaccct cggcgaacgt gccttcatga accgcactgt 780gggtgagatc atgtggggct acaaggaccc ccttgtgaat ctcatcaaca agtactttcc 840aggcatgttc cccttcaagg acaagttcgg attatttgct gagctcaaca actccgactc 900tgggctcttc acggtgttca cgggggtcca gaacatcagc aggatccacc tcgtggacaa 960gtggaacggg ctgagcaagg ttgacttctg gcattccgat cagtgcaaca tgatcaatgg 1020aacttctggg caaatgtggc cgcccttcat gactcctgag tcctcgctgg agttctacag 1080cccggaggcc tgccgatcca tgaagctaat gtacaaggag tcaggggtgt ttgaaggcat 1140ccccacctat cgcttcgtgg ctcccaaaac cctgtttgcc aacgggtcca tctacccacc 1200caacgaaggc ttctgcccgt gcctggagtc tggaattcag aacgtcagca cctgcaggtt 1260cagtgccccc ttgtttctct cccatcctca cttcctcaac gctgacccgg ttctggcaga 1320agcggtgact ggcctgcacc ctaaccagga ggcacactcc ttgttcctgg acatccaccc 1380ggtcacggga atccccatga actgctctgt gaaactgcag ctgagcctct acatgaaatc 1440tgtcgcaggc attggacaaa ctgggaagat tgagcctgtg gtcctgccgc tgctctggtt 1500tgcagagagc ggggccatgg agggggagac tcttcacaca ttctacactc agctggtgtt 1560gatgcccaag gtgatgcact atgcccagta cgtcctcctg gcgctgggct gcgtcctgct 1620gctggtccct gtcatctgcc aaatccggag ccaagagaaa tgctatttat tttggagtag 1680tagtaaaaag ggctcaaagg ataaggaggc cattcaggcc tattctgaat ccctgatgac 1740atcagctccc aagggctctg tgctgcagga agcaaaactg tagggtcctg aggacaccgt 1800gagccagcca ggcctggccg ctgggcctga ccggcccccc agcccctaca ccccgcttct

1860cccggactct cccagcggac agccccccag ccccacagcc tgagcctccc agctgccatg 1920tgcctgttgc acacctgcac acacgccctg gcacacatac acacatgcgt gcaggcttgt 1980gcagacactc agggatggag ctgctgctga agggacttgt agggagaggc tcgtcaacaa 2040gcactgttct ggaaccttct ctccacgtgg cccacaggcc tgaccacagg ggctgtgggt 2100cctgcgtccc cttcctcggg tgagcctggc ctgtcccgtt cagccgttgg gcccaggctt 2160cctcccctcc aaggtgaaac actgcagtcc cggtgtggtg gctccccatg caggacgggc 2220caggctggga gtgccgcctt cctgtgccaa attcagtggg gactcagtgc ccaggccctg 2280gccacgagct ttggccttgg tctacctgcc aggccaggca aagcgccttt acacaggcct 2340cggaaaacaa tggagtgagc acaagatgcc ctgtgcagct gcccgagggt ctccgcccac 2400cccggccgga ctttgatccc cccgaagtct tcacaggcac tgcatcgggt tgtctggcgc 2460ccttttcctc cagcctaaac tgacatcatc ctatggactg agccggccac tctctggccg 2520aagtggccgc aggctgtgcc cccgagctgc ccccaccccc tcacagggtc cctcagatta 2580taggtgccca ggctgaggtg aagaggcctg ggggccctgc cttccgggcg ctcctggacc 2640ctggggcaaa cctgtgaccc ttttctactg gaatagaaat gagttttatc atctttgaaa 2700aataattcac tcttgaagta ataaacgttt aaaaaaatgg gaaaaaaaaa aaaaaaaaa 2759282184DNAHomo sapiens 28gtgcgcgaac ggctccggcc cgcacgggtc gccagaggcg actgtgtgac actcggagtt 60tgctggggtc tccgtgggcg ggaggacttt ccagcgcaat ggcgactccc taagccccgc 120agcttctgcg cccgggaaag atatccaaga gatgcaaagc tctactgggc ccaggctgcc 180accccagagg cccccttccg tcccggggcc ggggctaggc caaggcgggc accaggactg 240cccagcctcc cggcccttcg cactggtaac cggttccggg gcggatgctt tttgcatctg 300acccggcgcg cccggtgacg ccttcgcgtc cagacggaag tgcgggcgga ggatccccag 360ccgggtccca agcctgtgcc tgagcctgag cctgagcctg agcccgagcc gggagccggt 420cgcgggggct ccgggctgtg ggaccgctgg gcccccagcg atggcgaccc tgtggggagg 480ccttcttcgg cttggctcct tgctcagcct gtcgtgcctg gcgctttccg tgctgctgct 540ggcgcagctg tcagacgccg ccaagaattt cgaggatgtc agatgtaaat gtatctgccc 600tccctataaa gaaaattctg ggcatattta taataagaac atatctcaga aagattgtga 660ttgccttcat gttgtggagc ccatgcctgt gcgggggcct gatgtagaag catactgtct 720acgctgtgaa tgcaaatatg aagaaagaag ctctgtcaca atcaaggtta ccattataat 780ttatctctcc attttgggcc ttctacttct gtacatggta tatcttactc tggttgagcc 840catactgaag aggcgcctct ttggacatgc acagttgata cagagtgatg atgatattgg 900ggatcaccag ccttttgcaa atgcacacga tgtgctagcc cgctcccgca gtcgagccaa 960cgtgctgaac aaggtagaat atgcacagca gcgctggaag cttcaagtcc aagagcagcg 1020aaagtctgtc tttgaccggc atgttgtcct cagctaattg ggaattgaat tcaaggtgac 1080tagaaagaaa caggcagaca actggaaaga actgactggg ttttgctggg tttcatttta 1140ataccttgtt gatttcacca actgttgctg gaagattcaa aactggaagc aaaaacttgc 1200ttgatttttt tttcttgtta acgtaataat agagacattt ttaaaagcac acagctcaaa 1260gtcagccaat aagtcttttc ctatttgtga cttttactaa taaaaataaa tctgcctgta 1320aattatcttg aagtccttta cctggaacaa gcactctctt tttcaccaca tagttttaac 1380ttgactttca agataatttt cagggttttt gttgttgttg ttttttgttt gtttgttttg 1440gtgggagagg ggagggatgc ctgggaagtg gttaacaact tttttcaagt cactttacta 1500aacaaacttt tgtaaataga ccttaccttc tattttcgag tttcatttat attttgcagt 1560gtagccagcc tcatcaaaga gctgacttac tcatttgact tttgcactga ctgtattatc 1620tgggtatctg ctgtgtctgc acttcatggt aaacgggatc taaaatgcct ggtggctttt 1680cacaaaaagc agattttctt catgtactgt gatgtctgat gcaatgcatc ctagaacaaa 1740ctggccattt gctagtttac tctaaagact aaacatagtc ttggtgtgtg tggtcttact 1800catcttctag tacctttaag gacaaatcct aaggacttgg acacttgcaa taaagaaatt 1860ttattttaaa cccaagcctc cctggattga taatatatac acatttgtca gcatttccgg 1920tcgtggtgag aggcagctgt ttgagctcca atgtgtgcag ctttgaacta gggctggggt 1980tgtgggtgcc tcttctgaaa ggtctaacca ttattggata actggctttt ttcttcctat 2040gtcctctttg gaatgtaaca ataaaaataa tttttgaaac atccatcagt gtatctatct 2100atgtctccta gttttttcct cctccctctt ttgctgtata atgagattga agatataaag 2160acattttgta ccctgtaaaa aaaa 2184295135DNAHomo sapiens 29aactcaaggc ctgcttgata cgtccgccat tttgggcgct tcgctgatgg tgtcggtgag 60cgcgtttccc gcctgagcgc aactagcggc gggtcgtggg cacctccagg agagcttgtt 120tcatatccat atcccactgt attcctgcta atctgctaat gcagtaaatt ggaggaaaac 180tgttaccagg ataacctgta atgggcaagg agccacaaag aagaaaacat ttcttttaat 240ttttaaactt ggtttgaaag accagcatgt tttggaaatt tgatcttcac tcatcatccc 300acatagacac acttctagaa agagaagatg taacactgaa ggagttaatg gatgaggaag 360atgttttaca ggaatgtaaa gctcagaacc gcaaacttat agagtttctg ttaaaagcag 420aatgtctcga agatttagtc tcattcatta tagaagaacc acctcaagac atggatgaaa 480agatcagata caagtatcca aatatatctt gtgagttgct cacttctgat gtctcccaga 540tgaatgatag actgggagaa gatgaatcct tgctaatgaa attatatagc ttcctcctaa 600acgattcccc tttgaatcca ctacttgcca gtttcttcag caaggtgcta agtattctta 660tcagcagaaa accagaacag attgtggatt tcttaaagaa gaagcatgat tttgtagacc 720ttattataaa gcacatagga acttctgcta tcatggattt gttgctcagg ctcctgacgt 780gtatcgaacc tccacagccc aggcaagatg tgctgaattg gttaaatgag gagaaaatta 840tccagaggct tgtggaaata gttcatccat cgcaagaaga agatcgacat tcaaatgcat 900cacaatcact ttgtgaaatt gttcgcctga gcagagacca gatgttacaa attcagaaca 960gtacagagcc cgaccccctg cttgccactc tagaaaagca agaaattata gagcagcttc 1020tatcaaatat tttccacaag gagaaaaatg agtcagccat agtcagtgca atccagatat 1080tgctgacttt acttgagaca cgacgaccaa catttgaagg ccatatagag atctgcccac 1140caggcatgag ccattcagct tgttcagtaa acaagagtgt tctagaagcc atcagaggaa 1200gacttggatc ttttcatgaa ctcctgctgg agccacccaa gaaaagtgtg atgaagacca 1260catggggtgt gctggatcct cctgtgggga atacccggtt gaatgtcatt aggttgatat 1320ccagcctgct tcaaaccaat accagcagta taaatgggga ccttatggag ctgaatagca 1380ttggagtcat attgaacatg ttcttcaagt atacatggaa taactttttg catacacaag 1440tggaaatttg tattgcactg attcttgcaa gtccttttga aaacacagaa aatgccacaa 1500ttaccgatca agactccact ggtgataatt tgttattaaa acatcttttc caaaaatgtc 1560aattaataga acgaatactt gaagcctggg aaatgaatga gaagaaacag gctgagggag 1620gaagacggca tggttacatg ggacacctaa cgaggatagc taactgtatc gtgcacagca 1680ctgacaaggg ccccaacagt gcattagtgc agcagcttat caaagatctt cccgacgaag 1740tcagggaacg atgggagacg ttctgcacaa gctccttagg agaaactaac aagaggaaca 1800cggtagatct agttacaacc tgccatattc attcatccag tgatgatgaa attgacttta 1860aagaaacggg tttctcacag gattcttctt tgcagcaagc cttttctgat tatcagatgc 1920aacaaatgac gtccaatttt attgaccagt ttggcttcaa cgatgagaag tttgcagatc 1980aagatgacat tggcaatgtt tcttttgatc gagtatcaga catcaacttt actctcaata 2040caaatgaaag tggaaatatt gccttgtttg aagcatgttg taaggaaaga atacaacagt 2100ttgatgatgg tggctctgat gaggaagata tatgggagga aaagcacatc gcattcacac 2160cagaatccca aagacgatcc agctcgggga gtacagacag tgaggaaagt acagactctg 2220aagaagaaga tggagcaaag caagacttgt ttgaacccag cagtgccaac acggaggata 2280aaatggaggt ggacctgagt gaaccaccca actggtcagc taactttgat gtcccaatgg 2340aaacaaccca cggtgctcca ttggattctg tgggatctga tgtctggagc acagaggagc 2400cgatgccaac taaagagacg ggctgggctt ctttttcaga gttcacgtct tccctgagca 2460caaaagattc tttaaggagt aattctccag tggaaatgga aaccagcact gaacccatgg 2520accctctgac tcccagtgcg gctgccctgg cagtgcagcc agaagcggca ggcagtgtgg 2580ccatggaagc cagctctgac ggagaggagg atgcagaaag tacagacaag gtaactgaga 2640cagtgatgaa tggcggcatg aaggaaacgc tcagcctcac tgtagatgcc aagacagaga 2700ctgcggtctt caaaagtgag gaagggaaac tgtctacctc tcaagatgct gcttgtaaag 2760acgcagagga gtgtcccgag actgcagagg cgaagtgcgc ggcgcccagg cctcccagca 2820gcagtcccga gcagagtgcc tccgatgcct gtctgttgct ccttaggact ggccaaccaa 2880gcgcaccagg tgacacttca gtgaatggcc ctgtatgacg ggtgacgtct gctgctgctg 2940actgaggact gcagaccgcc accactcagg ggctctggag gggtcagctg gagcccacca 3000agctgtcact gctgcactca ctctgcaagg gatcaggacc agcaaccttt atattctaga 3060ttctaagaca ttgtacagag aaattcagaa gtgtaaaaat attgcacatt gacaaatacc 3120aagaattttt gcgtatgttt atattgtatt gttctaaata atgggtagcc tgtgaaataa 3180gatcttgcca cccatgtaat aatagtagta atactatagt taaaatggct gtaagaatag 3240ttttataaaa gtgaatacac agatctattg tatttgaaac ataactttga caattattag 3300tgtgaccaaa gtattaggcg gttttcatac atttttcacc ttgtacaaaa ttatgaattc 3360atttttcctc caggccgaca aggagttgta gaatgaaaat gccctctaag tgttattttg 3420gttgttctaa cttacaaaag tgattttgaa taagaaatat ttggtgttct ttttataacc 3480agtttttgat tggtaattgt tttctgtatt gtttaaaacg gatcaaaaat gtaagtctat 3540tggtagagat taagtaaagt atttattgct acatcatagt tgataaattg atgttatcgt 3600aaagccatat gttctgttca agtcttgttt gcttgaaatg attattccta caagtgaaac 3660actagactat ttggagtgta tatggcttgt gttttgggat tttttttttt tttttttggc 3720ttttgttttt gtttgttttt ttgtttcatt tggtagttca tctgcctttt aacccattca 3780ccaaaattta ccttgttaac aagcatcacc aatgaacatt tcagagcaat ctgcatattt 3840aacagaccta aaataaatcc tattaggcaa gtcagttgaa aatgctcgtg ctgctaatgg 3900aattagagtg cgttcatttt acaggctagt attttaaaag tagaaatcaa aatctggcac 3960cgaagcatgc taattgttta ctgtaccttg tgaggttttc actcataaat ttaaaccagt 4020gtattttttt agaactggtt tgtgtatata tatagtgatt atggatacta attcaatgta 4080atttataatt ttctatgtca atacaaaaat acatcacagc cttctcaaac agctcaagca 4140atatattgta tattgccata tcgtctggtg aaagggttaa attacttcac ctcttgcact 4200tttagatgca aatcagtttt tcatttctgt aatagaaaat tattcacgta tttttacatc 4260atttgttttt cctgaccagt atttaaaacc aaaaggatat tctgaaaaat ggccaacaat 4320ttttttagaa gtagcatccc aagcagcgtg cctaaacatt acattgcata tggaaataaa 4380agaatcaaac gtctaatgcc ttattatttc tgatttcctt tttcatttta agtggtgtgg 4440agattccagc actcccagga cagtggagtc agcagtaagc cctgggacag gtggcaaggg 4500tgggtccctt gacctttgca cgcctcctca ggaaccccct ttcccgggtg agcccctctc 4560tgaagagact gtccttgggc ctcctctgga agcagcaccc ccagaggaca gggctcctcc 4620tgcttgcctc agggctgcct gacttgaatg gcgttggacc tcggggatta ctggtagata 4680atatgctctg gtctcgcctg gtggtgagtt ttgccagcca tggccagggt ttggctccac 4740tggtggcaca cgtggcctcc gtggtatgga cctggtggct tctccatccc actgtggcct 4800ctgtggtatg gacctggtgg cttctccatc ctacccaagg taacagtgtc ttgcttcatc 4860ccactgactg ctgggagaga gcctctggga cttttctttg gggcatcatt ttgttttgtc 4920tttcgtagca gggaaaggat atgacaatgg ggaggacagt tcttttggag gttggagggg 4980ccaagccaag gacaggagca agtgtgccct cattttgttt ctacttttaa tttctgtgtg 5040ttggccatac tgaattatga gactaacaga tgtctacaat acaatacctg tattcaaaat 5100aacaaaaata aagcctgatt ctttgtttct agaaa 51353076DNAHomo sapiens 30tgagggagga agacggcatg gttacatggg acacctaacg aggatagcta actgtatcgt 60gcacagcact gacaag 763166DNAHomo sapiens 31gacagatttc taccactcca aacgccggct gatcttctcc aagaggaagc cctaatccgc 60ccacag 66

Claims

1. A radiation biodosimetry assay system, comprising a plurality of in vitro nucleic acid amplification reaction mixtures, each amplification reaction mixture comprising: (a) a probe of at least 10 nucleotides directed to at least one of SEQ ID NOs: 1-39, or the complementary sequences thereof, labeled with a fluorescent dye and a quencher; and (b) one or more primer pairs, each primer pair comprising primers of at least 10 nucleotides directed to at least one of SEQ ID NOs: 1-39, or a complementary sequence thereof.

2. The radiation biodosimetry assay system of claim 1, wherein the system comprises primers of at least 10 nucleotides and probes of at least 10 nucleotides directed to at least two of SEQ ID NOs: 1-39.

3. The radiation biodosimetry assay system of claim 2, wherein the system comprises primers of at least 10 nucleotides and probes of at least 10 nucleotides directed to at least three of SEQ ID NOs: 1-39.

4. The radiation biodosimetry assay system of claim 1, wherein the radiation biodosimetry assay system additionally comprises mRNA, or cDNA derived therefrom, from a subject exposed to ionizing radiation before the mRNA was obtained.

5. The radiation biodosimetry assay system of claim 1, wherein the in vitro nucleic acid amplification reaction mixtures are provided in a multi-well plate.

6. The radiation biodosimetry assay system of claim 5, wherein at least two nucleic acid probes directed to at least two different nucleic acid targets are in the same wells of the multi-well plate.

7. A radiation biomarker assay kit, comprising a nucleic acid probe set comprising a plurality of nucleic acid probes of at least 10 nucleotides each that are directed to at least three of SEQ ID NOs: 1-39 or the complementary sequences thereof, the nucleic acid probe set further comprising a probe detectably labeled with a fluorescent dye and a quencher and configured for PCR amplification, a set of primer pairs comprising a plurality of primer pairs each comprising primers of at least 10 nucleotides that are directed to at least three of SEQ ID NOs: 1-39 or the complementary sequences thereof, and instructions for calculating an estimate of absorbed radiation dose from a fluorescence value obtained by contacting in vitro an mRNA sample from a human subject suspected of suffering from radiation exposure or cDNA derived therefrom to the nucleic acid probe set and a thermostable polymerase under PCR conditions.

8. The radiation biomarker assay kit of claim 7, wherein the nucleic acid probe set comprises probes of at least 10 nucleotides directed to at least four of SEQ ID NOs: 1-39.

9. The radiation biomarker assay kit of claim 7, wherein the nucleic acid probe set comprises probes of at least 10 nucleotides directed to at least five of SEQ ID NOs: 1-39.

10. The radiation biomarker assay kit of claim 7, further comprising radiation exposure positive and negative control mRNA samples or cDNAs thereof.

11. The radiation biomarker assay kit of claim 7, wherein the nucleic acid probes are provided in a multi-well plate.

12. A method for estimating absorbed dose of ionizing radiation exposure received by a subject, comprising (i) determining the mRNA expression levels of mRNAs comprising at least one of SEQ ID NOs: 1-39 in a stabilized blood sample comprising mRNA from the subject to obtain an expression profile; and (ii) transforming the gene expression profile into an estimate of absorbed radiation dose for the subject based on a mathematical algorithm.

13. (canceled)

14. (canceled)

15. The method of claim 12, wherein transforming in step (ii) comprises calculating an estimate of absorbed radiation dose from a fluorescence value obtained by contacting in vitro an mRNA sample from a human subject suspected of suffering from radiation exposure or cDNA derived therefrom to a nucleic acid probe set and a thermostable polymerase under PCR conditions.

16. The method of claim 15, wherein the nucleic acid probe set comprises a plurality of nucleic acid probes of at least 10 nucleotides each that are directed to at least three of SEQ ID NOs: 1-39 or the complementary sequences thereof, the nucleic acid probe set further comprising a probe detectably labeled with a fluorescent dye and a quencher and configured for PCR amplification.

17. The method of claim 15, wherein the mRNA sample from a human subject or cDNA derived therefrom is further contacted to a set of primer pairs comprising a plurality of primer pairs each comprising primers of at least 10 nucleotides that are directed to at least three of SEQ ID NOs: 1-39 or the complementary sequences thereof.

18. A method for radiation treatment triage of a subject in need thereof comprising: (i) determining the mRNA expression levels of mRNAs comprising at least one of SEQ ID NOs: 1-39 in a stabilized blood sample comprising mRNA from the subject to obtain a gene expression profile; and (ii) providing a suitable treatment for radiation exposure to the subject based on the expression levels of the genes.

19. (canceled)

20. (canceled)

21. The method of claim 18, further comprising transforming the gene expression profile into an estimate of absorbed radiation dose for the subject.

22. The method of claim 21, wherein transforming comprises calculating an estimate of absorbed radiation dose from a fluorescence value obtained by contacting in vitro an mRNA sample from a human subject suspected of suffering from radiation exposure or cDNA derived therefrom to a nucleic acid probe set and a thermostable polymerase under PCR conditions suitable for amplification of the mRNA or cDNA.

23. The method of claim 22, wherein the nucleic acid probe set comprises a plurality of nucleic acid probes of at least 10 nucleotides each that are directed to at least three of SEQ ID NOs: 1-39 or the complementary sequences thereof, the nucleic acid probe set further comprising a probe detectably labeled with a fluorescent dye and a quencher and configured for PCR amplification.

24. The method of claim 22, wherein the mRNA sample from a human subject or cDNA derived therefrom is further contacted to a set of primer pairs comprising a plurality of primer pairs each comprising primers of at least 10 nucleotides that are directed to at least three of SEQ ID NOs: 1-39 or the complementary sequences thereof.