U.S. patent application number 16/630092 was filed with the patent office on 2020-05-28 for mixtures comprising a biopesticide and a nitrification inhibitor.
The applicant listed for this patent is BASF SE. Invention is credited to Daniella Lohe, Barbara Nave, Gregor Pasda, Markus Schmid, Karl-Heinrich Schneider, Maarten Staal, Alexander Wissemeier, Wolfram Zerulla, Sascha Shuxia Zhu.
Application Number | 20200163342 16/630092 |
Document ID | / |
Family ID | 59313116 |
Filed Date | 2020-05-28 |
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United States Patent
Application |
20200163342 |
Kind Code |
A1 |
Nave; Barbara ; et
al. |
May 28, 2020 |
MIXTURES COMPRISING A BIOPESTICIDE AND A NITRIFICATION
INHIBITOR
Abstract
Described herein are pesticidal mixtures including as active
components at least one specific nitrification inhibitor (compound
I) and at least one biopesticide (compound II). Also described
herein are a method for controlling phytopathogenic harmful fungi,
or for improving the nitrification-inhibiting effect, or for
increasing the health of a plant using mixtures of at least one
compound I and at least one compound II and a method of using the
mixtures comprising compounds I and compounds II for controlling
phytopathogenic harmful fungi or to increasing the health of a
plant. Also described herein are agrochemical compositions
including these mixtures. Also described herein is plant
propagation material including these mixtures or agrochemical
compositions.
Inventors: |
Nave; Barbara;
(Limburgerhof, DE) ; Pasda; Gregor; (Limburgerhof,
DE) ; Wissemeier; Alexander; (Limburgerhof, DE)
; Staal; Maarten; (Limburgerhof, DE) ; Schneider;
Karl-Heinrich; (Limburgerhof, DE) ; Schmid;
Markus; (Limburgerhof, DE) ; Zerulla; Wolfram;
(Limburgerhof, DE) ; Lohe; Daniella;
(Limburgerhof, DE) ; Zhu; Sascha Shuxia;
(Ludwigshafen, DE) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
BASF SE |
Ludwigshafen am Rhein |
|
DE |
|
|
Family ID: |
59313116 |
Appl. No.: |
16/630092 |
Filed: |
July 5, 2018 |
PCT Filed: |
July 5, 2018 |
PCT NO: |
PCT/IB2018/054949 |
371 Date: |
January 10, 2020 |
Current U.S.
Class: |
1/1 |
Current CPC
Class: |
C05G 3/60 20200201; C05G
3/90 20200201; A01N 63/20 20200101; Y02P 60/21 20151101 |
International
Class: |
A01N 63/20 20200101
A01N063/20; C05G 3/60 20200101 C05G003/60; C05G 3/90 20200101
C05G003/90 |
Foreign Application Data
Date |
Code |
Application Number |
Jul 10, 2017 |
EP |
17180510.4 |
Claims
1. A mixture comprising as active components 1) at least one active
compound I (nitrification inhibitor) selected from the group
consisting of: a) 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid
and/or 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid, and/or a
derivative thereof, and/or a salt thereof, b) glycolic acid
addition salt of 3,4-dimethyl pyrazole (3,4-dimethyl pyrazolium
glycolate), and/or an isomer thereof, and/or a derivative thereof,
c) citric acid addition salt of 3,4-dimethyl pyrazole (3,4-dimethyl
pyrazolium citrate), and/or an isomer thereof, and/or a derivative
thereof, d) lactic acid addition salt of 3,4-dimethyl pyrazole
(3,4-dimethyl pyrazolium lactate), and/or an isomer thereof, and/or
a derivative thereof, e) mandelic acid addition salt of
3,4-dimethyl pyrazole (3,4-dimethyl pyrazolium mandelate), and/or
an isomer thereof, and/or a derivative thereof, f) 1,2,4-triazole,
and/or a derivative thereof, and/or a salt thereof, g)
4-Chloro-3-methylpyrazole, and/or an isomer thereof, and/or a
derivative thereof, and/or a salt thereof, h)
N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)acetamide, and/or an isomer
thereof, and/or a derivative thereof, and/or a salt thereof, i)
N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)formamide, and/or an isomer
thereof, and/or a derivative thereof, and/or a salt thereof, j)
N-((3(5),4-dimethylpyrazole-1-yl)methyl)formamide, and/or an isomer
thereof, and/or a derivative thereof, and/or a salt thereof, k)
N-((4-chloro-3(5)-methyl-pyrazole-1-yl)methyl)formamide, and/or an
isomer thereof, and/or a derivative thereof, and/or a salt thereof,
l) a reaction adduct of dicyandiamide, urea and formaldehyde, or a
triazonyl-formaldehyde-dicyandiamide adduct m)
2-cyano-1-(4-oxo-1,3,5-triazinan-1-yl)methyl)guanidine, n)
1-((2-cyanoguanidino)methyl)urea, and o)
2-cyano-1-((2-cyanoguanidino)methyl)guanidine, p)
2-chloro-6-(trichloromethyl)-pyridine (nitrapyrin or N-serve), q)
dicyandiamide (DCD, DIDIN), r) 3,4-dimethyl pyrazole phosphate,
and/or 4,5-dimethyl pyrazole phosphate (DMPP, ENTEC), and/or an
isomer thereof, and/or a derivative thereof, s)
3,4-dimethylpyrazole, and/or 4,5-dimethylpyrazole (DMP), and/or an
isomer thereof, and/or a derivative thereof, and/or a salt thereof,
and/or an acid addition salt thereof, t) ammoniumthiosulfate (ATU),
u) neem, and/or products based on ingredients of neem, v) linoleic
acid, w) alpha-linolenic acid, x) methyl p-coumarate, y) methyl
ferulate, z) methyl 3-(4-hydroxyphenyl) propionate (MHPP), aa)
Karanjin, bb) brachialacton, cc) p-benzoquinone sorgoleone, dd)
4-amino-1,2,4-triazole hydrochloride (ATC), ee) 1-amido-2-thiourea
(ASU), ff) 2-amino-4-chloro-6-methylpyrimidine (AM), gg)
2-mercapto-benzothiazole (MBT), hh)
5-ethoxy-3-trichloromethyl-1,2,4-thiodiazole (terrazole,
etridiazole), ii) 2-sulfanilamidothiazole (ST), jj) 3-methylpyrazol
(3-MP), kk) 1,2,4-triazol thiourea (TU), ll) cyan amide, mm)
melamine, nn) zeolite powder, oo) catechol, pp) benzoquinone, qq)
sodium tetra borate, rr) allylthiourea, ss) chlorate salts, and tt)
zinc sulfate; and 2) at least one active compound II (biopesticide)
selected from groups L1) to L6): L1) Microbial pesticides with
fungicidal, bactericidal, viricidal and/or plant defense activator
activity: Ampelomyces quisqualis, Aspergillus flavus, Aureobasidium
pullulans, Bacillus altitudinis, Bacillus amyloliquefaciens,
Bacillus licheniformis, Bacillus megaterium, Bacillus mojavensis,
Bacillus mycoides, Bacillus pumilus, Bacillus simplex, Bacillus
solisalsi, Bacillus subtilis, Bacillus subtilis var.
amyloliquefaciens, Candida oleophila, Candida saitoana, Clavibacter
michiganensis (bacteriophages), Coniothyrium minitans,
Cryphonectria parasitica, Cryptococcus albidus, Dilophosphora
alopecuri, Fusarium oxysporum, Clonostachys rosea f. catenulata
(also named Gliocladium catenulatum), Gliocladium roseum,
Lysobacter antibioticus, Lysobacter enzymogenes, Metschnikowia
fructicola, Microdochium dimerum, Microsphaeropsis ochracea,
Muscodor albus, Paenibacillus alvei, Paenibacillus epiphyticus,
Paenibacillus polymyxa, Paenibacillus agglomerans, Pantoea vagans,
Penicillium bilaiae, Phlebiopsis gigantea, Pseudomonas
chlororaphis, Pseudomonas fluorescens, Pseudomonas putida,
Pseudozyma flocculosa, Pichia anomala, Pythium oligandrum,
Sphaerodes mycoparasitica, Streptomyces griseoviridis, Streptomyces
lydicus, Streptomyces violaceusniger, Talaromyces flavus,
Trichoderma asperellum, Trichoderma atroviride, Trichoderma
asperelloides, Trichoderma fertile, Trichoderma gamsii, Trichoderma
harmatum, Trichoderma harzianum, Trichoderma polysporum,
Trichoderma stromaticum, Trichoderma vixens, Trichoderma viride,
Typhula phacorrhiza, Ulocladium oudemansii, Verticillium dahlia,
zucchini yellow mosaic virus (avirulent strain); L2) Biochemical
pesticides with fungicidal, bactericidal, viricidal and/or plant
defense activator activity: chitosan (hydrolysate), fusaricidins,
paeniserines, paeniprolixines, harpin protein, laminarin, Menhaden
fish oil, natamycin, Plum pox virus coat protein, potassium or
sodium bicarbonate, Reynoutria sachalinensis extract, salicylic
acid, tea tree oil (Melaleuca alternifolia extract); L3) Microbial
pesticides with insecticidal, acaricidal, molluscidal and/or
nematicidal activity: Agrobacterium radiobacter, Bacillus cereus,
Bacillus firmus, Bacillus subtilis, Bacillus licheniformis,
Bacillus thuringiensis, Bacillus thuringiensis ssp. aizawai,
Bacillus thuringiensis ssp. israelensis, Bacillus thuringiensis
ssp. galleriae, Bacillus thuringiensis ssp. kurstaki, Bacillus
thuringiensis ssp. tenebrionis, Beauveria bassiana, Beauveria
brongniartii, Burkholderia rinojensis, Chromobacterium subtsugae,
Cydia pomonella granulovirus (CpGV), Cryptophlebia leucotreta
granulovirus (CrleGV), Flavobacterium spp., Helicoverpa armigera
nucleopolyhedrovirus (HearNPV), Heterorhabditis bacteriophora,
Isaria fumosorosea, Lecanicillium longisporum, Lecanicillium
muscarium, Metarhizium anisopliae, Metarhizium anisopliae var.
anisopliae, Metarhizium anisopliae var. acridum, Nomuraea rileyi,
Paecilomyces lilacinus, Paenibacillus popilliae, Pasteuria
nishizawae, Pasteuria penetrans, Pasteuria ramosa, Pasteuria
thornea, Pasteuria usgae, Phasmarhabditis hermaphrodita,
Pseudomonas fluorescens, Spodoptera littoralis nucleopolyhedrovirus
(SpliNPV), Steinernema carpocapsae, Steinernema feltiae,
Steinernema kraussei, Steinernema riobrave, Streptomyces galbus,
Streptomyces microflavus, Paecilomyces lilacinus; L4) Biochemical
pesticides with insecticidal, acaricidal, molluscidal, pheromone
and/or nematicidal activity: L-carvone, citral,
(E,Z)-7,9-dodecadien-1-yl acetate, ethyl formate, (E,Z)-2,4-ethyl
decadienoate (pear ester), (Z,Z,E)-7,11,13-hexadecatrienal, heptyl
butyrate, isopropyl myristate, lavanulyl senecioate, cis-jasmone,
2-methyl 1-butanol, methyl eugenol, methyl jasmonate,
(E,Z)-2,13-octadecadien-1-ol, (E,Z)-2,13-octadecadien-1-ol acetate,
(E,Z)-3,13-octadecadien-1-ol, R-1-octen-3-ol, pentatermanone,
potassium silicate, sorbitol actanoate,
(E,Z,Z)-3,8,11-tetradecatrienyl acetate,
(Z,E)-9,12-tetradecadien-1-yl acetate, Z-7-tetradecen-2-one,
Z-9-tetradecen-1-yl acetate, Z-11-tetradecenal,
Z-11-tetradecen-1-ol, Acacia negra extract, extract of grapefruit
seeds and pulp, Chenopodium ambrosioides extract, Catnip oil, Neem
oil, Quillay extract, Tagetes oil; L5) Microbial pesticides with
plant stress reducing, plant growth regulator, plant growth
promoting and/or yield enhancing activity: Azospirillum amazonense,
Azospirillum brasilense, Azospirillum lipoferum, Azospirillum
irakense, Azospirillum halopraeferens, Bradyrhizobium elkanii,
Bradyrhizobium japonicum, Bradyrhizobium spp., Bradyrhizobium
liaoningense, Bradyrhizobium lupini, Delftia acidovorans, Glomus
intraradices, Mesorhizobium spp., Mesorhizobium ciceri, Rhizobium
leguminosarum bv. phaseoli, Rhizobium leguminosarum bv. trifolii,
Rhizobium leguminosarum bv. viciae, Rhizobium tropici,
Sinorhizobium meliloti, Sinorhizobium medicae; and L6) Biochemical
pesticides with plant stress reducing, plant growth regulator
and/or plant yield enhancing activity: abscisic acid, aluminium
silicate (kaolin), 3-decen-2-one, formononectin, genistein,
hesperetin, homobrassinolide, humates, methyl jasmonate,
cis-jasmone, lysophosphatidyl ethanlamine, naringenin, polymeric
polyhydroxy acid, salicylic acid, Ascophyllum nodosum (Norwegian
kelp, Brown kelp) extract and Ecklonia maxima (kelp) extract,
zeolite (aluminosilicate), grape seed extract.
2. The mixture according to claim 1, wherein compound I is selected
from the group consisting of compounds LA to I.Z: I.A:
2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and/or
2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid, I.B: a salt of
2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and/or
2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid, I.C: a potassium
salt of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and/or
2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid, I.D: an ammonium
salt of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and/or
2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid, I.E: a sodium salt
of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and/or
2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid, I.F: 3,4-dimethyl
pyrazolium glycolate (DMPG), I.G: 3,4-dimethyl pyrazolium citrate
(DMPC), I.H: 3,4-dimethyl pyrazolium lactate (DMPL), I.J:
3,4-dimethyl pyrazolium lactate (DMPM), I.K: 1,2,4-triazole (TZ),
I.L: 4-Chloro-3-methylpyrazole (C1MP), I.M:
N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)acetamide, I.N:
N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)formamide, I.O:
N-((3(5),4-dimethylpyrazole-1-yl)methyl)formamide, I.P:
N-((4-chloro-3(5)-methyl-pyrazole-1-yl)methyl)formamide, I.Q:
reaction adduct of dicyandiamide, urea and formaldehyde, or a
triazonyl-formaldehyde-dicyandiamide adduct I.R:
2-cyano-1-((4-oxo-1,3,5-triazinan-1-yl)methyl)guanidine, I. S:
1-((2-cyanoguanidino)methyl)urea, I.T:
2-cyano-1-((2-cyanoguanidino)methyl)guanidine, I.U:
2-chloro-6-(trichloromethyl)-pyridine (nitrapyrin or N-serve), I.V:
dicyandiamide (DCD, DIDIN), I.W: 3,4-dimethyl pyrazole phosphate,
and/or 4,5-dimethyl pyrazole phosphate (DMPP, ENTEC), and/or an
isomer thereof, and/or a derivative thereof, I.X:
3,4-dimethylpyrazole, and/or 4,5-dimethylpyrazole (DMP), and/or an
isomer thereof, and/or a derivative thereof, and/or a salt thereof,
and/or an acid addition salt thereof, I.Y: ammoniumthiosulfate
(ATU), and I.Z: neem.
3. The mixture according to claim 1, wherein compound I is
2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and/or
2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid.
4. The mixture according to claim 1, wherein compound II is
selected from the group consisting of Bacillus amyloliquefaciens,
Bacillus firmus, Bacillus pumilus, Bacillus subtilis, Bacillus
licheniformis, Paenibacillus polymyxa, Paenibacillus epiphyticus,
Pasteuria nishizawae, Penicillium bilaiae, fusaricidins and
cis-jasmone.
5. The mixture according to claim 1, wherein compound II is
selected from: L1) Microbial pesticides with fungicidal,
bactericidal, viricidal and/or plant defense activator activity:
Ampelomyces quisqualis M-10 (L.1.1), Aspergillus flavus NRRL 21882
(L.1.2), Aureobasidium pullulans DSM 14940 (L1.3), Aureobasidium
pullulans DSM 14941 (L.1.4), Bacillus altitudinis 41KF2b (L.1.5),
Bacillus amyloliquefaciens AP-136 (L.1.6), Bacillus
amyloliquefaciens AP-188 (L.1.7), Bacillus amyloliquefaciens AP-218
(L.1.8), Bacillus amyloliquefaciens AP-219 (L.1.9), Bacillus
amyloliquefaciens AP-295 (L.1.10), Bacillus amyloliquefaciens
IN937a (L.1.11), Bacillus amyloliquefaciens IT-45 (L.1.12),
Bacillus amyloliquefaciens ssp. plantarum D747 (L.1.13), Bacillus
amyloliquefaciens ssp. plantarum FZB24 (L.1.14), Bacillus
amyloliquefaciens ssp. plantarum FZB42 (L.1.15), Bacillus
amyloliquefaciens ssp. plantarum GB03 (=Bacillus subtilis GB03)
(L.1.16), Bacillus amyloliquefaciens ssp. plantarum MBI600 (NRRL
B-50595) (L.1.17), Bacillus amyloliquefaciens ssp. plantarum
QST-713 (L.1.18), Bacillus amyloliquefaciens ssp. plantarum TJ1000
(L.1.19), Bacillus mojavensis AP-209 (L.1.20), Bacillus mycoides
AQ726 (L.1.21), Bacillus mycoides strain J (L.1.22), Bacillus
pumilus INR-7 (L.1.23), B. pumilus KFP9F (L.1.24), Bacillus pumilus
QST 2808 (L.1.25), Bacillus pumilus GHA 180 (L.1.26), Bacillus
solisalsi AP-217 (L.1.28), Bacillus subtilis CX-9060 (L.1.29),
Bacillus subtilis FB17 (L.1.30), Bacillus subtilis GB07 (L.1.31),
Candida oleophila 1-82 (L.1.32), Candida oleophila 0 (L.1.33),
Candida saitoana (L.1.34), Clavibacter michiganensis
(bacteriophages) (L.1.35), Coniothyrium minitans CON/M/91-08
(L.1.36), Cryphonectria parasitica (L.1.37), Cryptococcus albidus
(L.1.38), Dilophosphora alopecuri (L.1.39), Fusarium oxysporum
(L.1.40), Clonostachys rosea f. catenulata J1446 (L.1.41),
Gliocladium roseum 321U (L.1.42), Metschnikowia fructicola NRRL
Y-30752 (L.1.43), Microdochium dimerum (L.1.44), Microsphaeropsis
ochracea P130A (L.1.45), Muscodor albus QST 20799 (L.1.46),
Muscodor albus SA-13 (L.1.47), Paenibacillus alvei NAS6G6 (L.1.48),
Paenibacillus polymyxa PKB1 (L.1.49), Pantoea agglomerans E325
(L.1.90), Pantoea vagans C9-1 (L.1.50), Penicillium bilaiae ATCC
22348 (L.1.51), P. bilaiae ATCC 20851 (L.1.52), Penicillium bilaiae
ATCC 18309 (L.1.53), Phlebiopsis gigantea (L.1.54), Pichia anomala
WRL-76 (L.1.55), Pseudomonas sp. Proradix (L.1.56), Pseudomonas
chlororaphis MA 342 (L.1.57), P. fluorescens A506 (L.1.58), P.
fluorescens CL 145A (L.1.91), P. fluorescens NCIB 12089 (L.1.92),
P. fluorescens Pf-5 (L.1.93), P. fluorescens WCS 374 (L.1.94), P.
fluorescens ATCC 13525 (L.1.95), P. fluorescens CHAO (L.1.96), P.
putida ATCC 202153 (L.1.97), Pseudozyma flocculosa PF-A22 UL
(L.1.59), Pythium oligandrum DV 74 (L.1.60), Sphaerodes
mycoparasitica SMCD2220 (L.1.61), Streptomyces griseoviridis K61
(L.1.62), Streptomyces lydicus WYEC 108 (L.1.63), Streptomyces
violaceusniger XL-2 (L.1.64), Streptomyces violaceusniger YCED-9
(L.1.65), Talaromyces flavus V117b (L.1.66), Trichoderma asperellum
T34 (L.1.67), Trichoderma asperellum SKT-1 (L.1.68), Trichoderma
asperellum ICC 012 (L.1.69), Trichoderma atroviride LC52 (L.1.70),
Trichoderma atroviride CNCM I-1237 (L.1.71), Trichoderma
asperelloides JM41R (=Trichoderma fertile) (L.1.72), Trichoderma
gamsii ICC 080 (L.1.73), Trichoderma harmatum TH 382 (L.1.74),
Trichoderma harzianum T-35 (L.1.75), Trichoderma harzianum T-22
(L.1.76), Trichoderma harzianum T-39 (L.1.77); mixture of
Trichoderma harzianum ICC012 and Trichoderma viride ICC080
(L.1.78); Trichoderma polysporum (L.1.79); Trichoderma stromaticum
(L.1.80), Trichoderma virens GI-3 (L.1.81), Trichoderma virens G-41
(L.1.82), Trichoderma virens GL-21 (=Gliocladium virens GL-21)
(L.1.83), Trichoderma. virens G-41 (L.1.84), Trichoderma viride TV1
(L.1.85), Typhula phacorrhiza 94671 (L.1.86), Ulocladium oudemansii
HRU3 (L.1.87), Verticillium dahlia (L.1.88), zucchini yellow mosaic
virus (avirulent strain) (L.1.89), Bacillus licheniformis SB3086
(L.1.90), Paenibacillus polymyxa Lu16774 (L.1.91), Paenibacillus
polymyxa Lu17007 (L.1.92), Paenibacillus epiphyticus Lu17015
(L.1.93), Paenibacillus sp. NRRL B-50972 (L.1.94), Paenibacillus
sp. strain NRRL B-67129 (L.1.95), Bacillus pumilus strain GB34
(L.1.96); L2) Biochemical pesticides with fungicidal, bactericidal,
viricidal and/or plant defense activator activity: chitosan
(hydrolysate) (L.2.1), harpin protein (L.2.2), laminarin (L.2.3),
Menhaden fish oil (L.2.4), natamycin (L.2.5), Plum pox virus coat
protein (L.2.6), potassium bicarbonate (L.2.7), Reynoutria
sachalinensis extract (L.2.8), salicylic acid (L.2.9), potassium or
sodium bicarbonate (L.2.10), tea tree oil (Melaleuca alternifolia
extract) (L.2.11), fusaricidin A (L.2.12), fusaricidin B (L.2.13),
fusaricidin C (L.2.14), fusaricidin D (L.2.15), fusaricidin LI F03
(L.2.16), fusaricidin LI F04 (L.2.17), fusaricidin LI-F05 (L.2.18),
fusaricidin LI-F06 (L.2.18), fusaricidin LI-F07 (L.2.19),
fusaricidin LI-F08 (L.2.20), fusaricidin 1A (L.2.21), fusaricidin
1B (L.2.22), paeniserine A (L.2.23), paeniserine B (L.2.24)
paeniserine C (L.2.25), paeniserine D (L.2.26) paeniprolixine A
(L.2.27), paeniprolixine B (L.2.28), paeniprolixine C (L.2.29),
paeniprolixine D (L.2.30), paeniprolixine E (L.2.31),
paeniprolixine F (L.2.32), paeniprolixine G (L.2.33); L3) Microbial
pesticides with insecticidal, acaricidal, molluscidal and/or
nematicidal activity: Agrobacterium radiobacter K1026 (L.3.1), A.
radiobacter K84 (L.3.2), Bacillus firmus I-1582 (L.3.3); B.
thuringiensis ssp. aizawai strains: ABTS-1857 (L.3.4), SAN 401 I
(L.3.5), ABG-6305 (L.3.6) and ABG-6346 (L.3.7); B. t. ssp.
israelensis AM65-52 (L.3.8), B. t. ssp. israelensis SUM-6218
(L.3.9), B. t. ssp. galleriae SDS-502 (L.3.10), B. t. ssp. kurstaki
EG2348 (L.3.11), B. t. ssp. kurstaki SB4 (L.3.12), B. t. ssp.
kurstaki ABTS-351 (HD-1) (L.3.13), Beauveria bassiana ATCC 74040
(L.3.14), Beauveria bassiana GHA (L.3.15), Beauveria bassiana H123
(L.3.16), Beauveria bassiana DSM 12256 (L.3.17), Beauveria bassiana
PPM 5339 (L.3.18), B. brongniartii (L.3.19), Burkholderia
rinojensis A396 (L.3.20), Chromobacterium subtsugae PRAA4-1.sup.T
(L.3.21), Cydia pomonella granulosis virus V22 (L.3.22), Cydia
pomonella granulosis virus V1 (L.3.23), Cryptophlebia leucotreta
granulovirus (CrleGV) (L.3.57), Flavobacterium sp. H492 (L.3.60),
Helicoverpa armigera nucleopolyhedrovirus (HearNPV) (L.3.58),
Isaria fumosorosea Apopka-97 (L.3.24), Lecanicillium longisporum
KV42 (L.3.25), Lecanicillium longisporum KV71 (L.3.26),
Lecanicillium muscarium KV01 (L.3.27), Metarhizium anisopliae
FI-985 (L.3.28), Metarhizium anisopliae FI-1045 (L.3.29),
Metarhizium anisopliae F52 (L.3.30), Metarhizium anisopliae ICIPE
69 (L.3.31), Metarhizium anisopliae var. acridum IMI 330189
(L.3.32); Nomuraea rileyi strains: SA86101 (L.3.33), GU87401
(L.3.34), SR 86151 (L.3.35), CG128 (L.3.36) and VA9101 (L.3.37);
Paecilomyces fumosoroseus FE 9901 (L.3.38), Paecilomyces lilacinus
251 (L.3.39), Paecilomyces lilacinus DSM 15169 (L.3.40),
Paecilomyces lilacinus BCP2 (L.3.41), Paenibacillus popilliae
Dutky-1940 (NRRL B-2309=ATCC 14706) (L.3.42), Paenibacillus
popilliae Dutky 1 (L.3.43), Paenibacillus popilliae KLN 3 (L.3.56),
Pasteuria sp. Ph3 (L.3.44), Pasteuria sp. ATCC PTA-9643 (L.3.45),
Pasteuria sp. ATCC SD-5832 (L.3.46), P. nishizawae Pn1 (L.3.46), P.
penetrans (L.3.47), P. ramosa (L.3.48), P. sp. Pr-3 (L.3.49), P.
thornea (L.3.50), P. usgae (L.3.51), Pseudomonas fluorescens CL
145A (L.3.52), Spodoptera littoralis nucleopolyhedrovirus (SpliNPV)
(L.3.59), Steinernema carpocapsae (L.3.53), Steinernema feltiae
UK76 (L.3.54), Steinernema kraussei L137 (L.3.55), Beauveria
bassiana 147 (L.3.56), Beauveria bassiana NPP111B005 (L.3.57);
Bacillus subtilis linhagem QST 713 (L.3.58), Bacillus licheniformis
RTI184 (L.3.59), Paecilomyces lilacinus (L.3.60), Steinernema
riobrave 355 (L.3.61), Phasmarhabditis hermaphrodita DMG 0001
(L.3.62), Heterorhabditis bacteriophora GPS11 (L.3.63); L4)
Biochemical pesticides with insecticidal, acaricidal, molluscidal,
pheromone and/or nematicidal activity: L-carvone (L.4.1), citral
(L.4.2), (E,Z)-7,9-dodecadien-1-yl acetate (L.4.3), ethyl formate
(L.4.4), (E,Z)-2,4-ethyl decadienoate (pear ester) (L.4.5),
(Z,Z,E)-7,11,13-hexadecatrienal (L.4.6), heptyl butyrate (L.4.7),
isopropyl myristate (L.4.8), cis-jasmone (L.4.9), lavanulyl
senecioate (L.4.10), 2-methyl 1-butanol (L.4.11), methyl eugenol
(L.4.12), methyl jasmonate (L.4.13), (E,Z)-2,13-octadecadien-1-ol
(L.4.14), (E,Z)-2,13-octadecadien-1-ol acetate (L.4.15),
(E,Z)-3,13-octadecadien-1-ol (L.4.16), R-1-octen-3-ol (L.4.17),
pentatermanone (L.4.18), potassium silicate (L.4.19), sorbitol
actanoate (L.4.20), (E,Z,Z)-3,8,11-tetradecatrienyl acetate
(L.4.21), (Z,E)-9,12-tetradecadien-1-yl acetate (L.4.22),
Z-7-tetradecen-2-one (L.4.23), Z-9-tetradecen-1-yl acetate
(L.4.24), Z-11-tetradecenal (L.4.25), Z-11-tetradecen-1-ol
(L.4.26), Acacia negra extract (L.4.27), extract of grapefruit
seeds and pulp (L.4.28), Chenopodium ambrosioides extract (L.4.29),
Catnip oil (L.4.30), Neem oil (L.4.31), Quillay extract (L.4.32),
Tagetes oil (L.4.33); L5) Microbial pesticides with plant stress
reducing, plant growth regulator, plant growth promoting and/or
yield enhancing activity: Azospirillum amazonense BR 11140 (SpY2)
(L.5.1), A. brasilense Ab-V5 (L.5.74), A. brasilense Ab-V6
(L.5.75), A. brasilense AZ39 (L.5.2), A. brasilense XOH (L.5.3), A.
brasilense Sp245 (BR 11005) (L.5.4), A. brasilense BR 11002
(L.5.5), A. lipoferum BR 11646 (Sp31) (L.5.6), A. irakense (L.5.7),
A. halopraeferens (L.5.8), Bradyrhizobium sp. PNL01 (L.5.9),
Bradyrhizobium sp. (Arachis) CB1015 (L.5.10), Bradyrhizobium sp.
(Arachis) USDA 3446 (L.5.11), Bradyrhizobium sp. (Arachis) SEMIA
6144 (L.5.12), Bradyrhizobium sp. (Arachis) SEMIA 6462 (L.5.13),
Bradyrhizobium sp. (Arachis) SEMIA 6464 (L.5.14), Bradyrhizobium
sp. (Vigna) (L.5.15), Bradyrhizobium elkanii SEMIA 587 (L.5.16),
Bradyrhizobium elkanii SEMIA 5019 (L.5.17), Bradyrhizobium elkanii
U-1301 (L.5.18), Bradyrhizobium elkanii U-1302 (L.5.19),
Bradyrhizobium elkanii USDA 74 (L.5.20), Bradyrhizobium elkanii
USDA 76 (L.5.21), Bradyrhizobium elkanii USDA 94 (L.5.22), B.
elkanii USDA 3254 (L.5.23), Bradyrhizobium japonicum 532c (L.5.24),
Bradyrhizobium japonicum CPAC 15 (L.5.25), Bradyrhizobium japonicum
E-109 (L.5.26), Bradyrhizobium japonicum G49 (L.5.27),
Bradyrhizobium japonicum TA-11 (L.5.28), Bradyrhizobium japonicum
USDA 3 (L.5.29), Bradyrhizobium japonicum USDA 31 (L.5.30),
Bradyrhizobium japonicum USDA 76 (L.5.31), Bradyrhizobium japonicum
USDA 110 (L.5.32), Bradyrhizobium japonicum USDA 121 (L.5.33),
Bradyrhizobium japonicum USDA 123 (L.5.34), Bradyrhizobium
japonicum USDA 136 (L.5.35), Bradyrhizobium japonicum SEMIA 566
(L.5.36), Bradyrhizobium japonicum SEMIA 5079 (L.5.37),
Bradyrhizobium japonicum SEMIA 5080 (L.5.38), Bradyrhizobium
japonicum WB74 (L.5.39), Bradyrhizobium liaoningense (L.5.40),
Bradyrhizobium lupini LL13 (L.5.41), Bradyrhizobium lupini WU425
(L.5.42), Bradyrhizobium lupini WSM471 (L.5.43), Bradyrhizobium
lupini WSM4024 (L.5.44), Glomus intraradices RTI-801 (L.5.45),
Mesorhizobium sp. WSM1271 (L.5.46), Mesorhizobium sp. WSM1497
(L.5.47), Mesorhizobium ciceri CC1192 (L.5.48), Mesorhizobium
huakii (L.5.49), Mesorhizobium loti CC829 (L.5.50), Mesorhizobium
loti SU343 (L.5.51), Rhizobium leguminosarum bv. phaseoli RG-B10
(L.5.52), R. I. bv. trifolii RP113-7 (L.5.53), R. I. bv. trifolii
095 (L.5.57), R. I. bv. trifolii TA1 (L.5.58), R. I. bv. trifolii
CC283b (L.5.59), R. I. bv. trifolii CC275e (L.5.60), R. I. bv.
trifolii CB782 (L.5.61), R. I. bv. trifolii CC1099 (L.5.62), R. I.
bv. trifolii WSM1325 (L.5.63), R. I. bv. viciae SU303 (L.5.64), R.
I. bv. viciae WSM1455 (L.5.65), R. I. bv. viciae P1NP3Cst (=1435)
(L.5.66), R. I. bv. viciae RG-P2 (L.5.67), R. tropici PRF81
(L.5.68), R. tropici SEMIA 4077 (L.5.69), R. tropici CC511(L.5.70),
Sinorhizobium meliloti RCR2011 (L.5.71), S. meliloti NRG185
(L.5.72), S. meliloti RRI128 (L.5.73), Bacillus licheniformis
RTI184 (L.5.74), Bacillus licheniformis CH200 (L.5.75), Bacillus
simplex ABU 288 (L.5.76), Bradyrhizobium lupini LL13 (L.5.77),
Mesorhizobium ciceri CC1653 (L.5.78), Sinorhizobium medicae WSM1115
(L.5.79), Bradyrhizobium japonicum CB1809 (L.5.80), Bradyrhizobium
japonicum 3407 (L.5.81), Rhizobium tropici SEMIA 4088 (L.5.82),
Bradyrhizobium NC92 (L.5.83), Bradyrhizobium CB1024 (L.5.84); L6)
Biochemical pesticides with plant stress reducing, plant growth
regulator and/or plant yield enhancing activity: abscisic acid
(L.6.1), aluminium silicate (kaolin) (L.6.2), 3-decen-2-one
(L.6.3), formononectin (L.6.4), genistein (L.6.5), hesperetin
(L.6.6), homobrassinolide (L.6.7), humates (L.6.8), methyl
jasmonate (L.6.9), cis-jasmone (L.6.10), lysophosphatidyl
ethanlamine (L.6.11), naringenin (L.6.12), polymeric polyhydroxy
acid (L.6.13), salicylic acid (L.6.14), Ascophyllum nodosum
(Norwegian kelp, Brown kelp) extract (L.6.15) and Ecklonia maxima
(kelp) extract (L.6.16), zeolite (aluminosilicate) (L.6.17), grape
seed extract (L.6.18).
6. The mixture according to claim 1, wherein compound II is
selected from the group consisting of Bacillus firmus CNCM I-1582
(L.3.3), Bacillus amyloliquefaciens ssp. plantarum MBI600 (NRRL
B-50595) (L.1.17), Bacillus subtilis linhagem QST 713 (L.3.58),
Bacillus licheniformis RTI184 (L.3.59), Paenibacillus polymyxa
Lu16774 (L.1.91), Paenibacillus polymyxa Lu17007 (L.1.92),
Paenibacillus epiphyticus Lu17015 (L.1.93), Pasteuria nishizawae
Pn1 (L.3.46), Penicillium bilaiae ATCC 22348 (L.1.51), Penicillium
bilaiae ATCC 20851 (L.1.52) and Penicillium bilaiae ATCC 18309
(L.1.53).
7. The mixture according to claim 1, wherein compound II is
selected from the group consisting of Bacillus firmus CNCM I-1582
(L.3.3), Bacillus amyloliquefaciens ssp. plantarum MBI600 (NRRL
B-50595) (L.1.17), Bacillus subtilis linhagem QST 713 (L.3.58),
Bacillus licheniformis RTI184 (L.3.59), Paenibacillus polymyxa
Lu16774 (L.1.91), Paenibacillus polymyxa Lu17007 (L.1.92),
Paenibacillus epiphyticus Lu17015 (L.1.93), Pasteuria nishizawae
Pn1 (L.3.46), Penicillium bilaiae ATCC 22348 (L.1.51), Penicillium
bilaiae ATCC 20851 (L.1.52) and Penicillium bilaiae ATCC 18309
(L.1.53).
8. The mixture according to claim 1, wherein compound II is
Bradyrhizobium japonicum.
9. The mixture according to claim 1, wherein compound II is
Bradyrhizobium japonicum 532c (L.5.24).
10. The mixture according to claim 1, wherein compound II is grape
seed extract (L.6.18).
11. The mixture according to claim 1, wherein compound I and
compound II are present in a synergistically effective amount,
and/or in a synergistically nitrification inhibitor (NI) effective
amount, and/or in a synergistically pesticidally effective amount,
and/or in a synergistically plant health effective amount.
12. The mixture according to claim 1, wherein compound I and
compound II are present in a weight ratio of from 100:1 to 1:100,
wherein a total weight of compound II is based on an amount of the
solid material (dry matter) of compound II, or wherein the total
weight of compound II is calculated on a basis of an amount of CFU
of compound II, wherein 1.times.10.sup.9 CFU equals one gram of
total weight of compound II.
13. The mixture according to claim 1, further comprising a
fertilizer.
14. An agrochemical composition, comprising an auxiliary and a
mixture according to claim 1.
15. A method of using the mixture as defined in claim 1 for
nitrification inhibition, for controlling phytopathogenic harmful
fungi or for increasing health of a plant.
16. A method for controlling phytopathogenic harmful fungi,
comprising treating the fungi, their habitat or seed, soil or
plants to be protected against fungal attack with an effective
amount of the mixture as defined in claim 1.
17. A method for increasing health of a plant, comprising treating
the plant or plant propagation material or soil where the plants
are to grow with an effective amount of the mixture as defined in
claim 1.
18. The methods as claimed in claim 16, wherein the at least one
compound I and the at least one compound II are applied
simultaneously, either as a mixture or separately, or subsequently
to plant propagules.
19. Plant propagation material, the material comprising a mixture
as defined in claim 1, in an amount of from 0.1 to 10 kg active
substances per 100 kg of seed.
Description
[0001] The present invention relates to the mixture comprising
nitrification inhibitors (compound I) and biopesticides (compound
II). Moreover, the invention relates to the use of this combination
comprising nitrification inhibitors (compound I) and biopesticides
(compound II) for increasing the health of a plant, and/or for
providing better crop yields and/or a better quality of the plants
or crops, and/or for contributing to a better resistance to stress,
and/or for reducing of the quantity of pesticides used, and/or for
avoiding the development of resistances against the respective
pesticides. Furthermore, the present invention relates to methods
for increasing the health of a plant comprising the treatment of
plants, soil and/or loci with said mixture comprising the
nitrification inhibitor (compound I) and a biopesticide (compound
II).
[0002] Nitrogen is an essential element for plant growth, plant
health and reproduction. About 25% of the plant available nitrogen
in soils (ammonium and nitrate) originate from decomposition
processes (mineralization) of organic nitrogen compounds such as
humus, plant and animal residues and organic fertilizers.
Approximately 5% derive from rainfall. On a global basis, the
biggest part (70%), however, are supplied to the plant by inorganic
nitrogen fertilizers. The mainly used nitrogen fertilizers comprise
ammonium compounds or derivatives thereof, i.e. nearly 90% of the
nitrogen fertilizers applied worldwide is in the NH.sub.4.sup.+
form (Subbarao et al., 2012, Advances in Agronomy, 114, 249-302) or
are based on neem-extract, including various compounds such as
neemoil-coated fertilizers, neem-coated fertilizers, nimin-coated
fertilizers and fertilizers with neem cake from the Indian neem
tree (Azadirachta indica). This is, inter alia, due to the fact
that NH.sub.4.sup.+ assimilation is energetically more efficient
than assimilation of other nitrogen sources such as
NO.sub.3.sup.-.
[0003] Moreover, being a cation, NH.sub.4.sup.+ is held
electrostatically by the negatively charged clay surfaces and
functional groups of soil organic matter. This binding is strong
enough to limit NH.sub.4.sup.+-loss by leaching to groundwater. By
contrast, NO.sub.3.sup.-, being negatively charged, does not bind
to the soil and is liable to be leached out of the plants' root
zone. In addition, nitrate may be lost by denitrification which is
the microbiological conversion of nitrate and nitrite
(NO.sub.2.sup.-) to gaseous forms of nitrogen such as nitrous oxide
(N.sub.2O) and molecular nitrogen (N.sub.2).
[0004] However, ammonium (NH.sub.4.sup.+) compounds are converted
by soil microorganisms to nitrates (NO.sub.3.sup.-) in a relatively
short time in a process known as nitrification. The nitrification
is carried out primarily by two groups of chemolithotrophic
bacteria, ammonia-oxidizing bacteria (AOB) of the genus
Nitrosomonas and Nitrobacter, which are ubiquitous component of
soil bacteria populations. The enzyme, which is essentially
responsible for nitrification is ammonia monooxygenase (AMO), which
was also found in ammonia-oxidizing archaea (Subbarao et al., 2012,
Advances in Agronomy, 114, 249-302).
[0005] The nitrification process typically leads to nitrogen losses
and environmental pollution. As a result of the various losses,
approximately 50% of the applied nitrogen fertilizers is lost
during the year following fertilizer addition (see Nelson and
Huber; Nitrification inhibitors for corn production (2001),
National Corn Handbook, Iowa State University).
[0006] As countermeasures, the use of nitrification inhibitors,
mostly together with fertilizers, was suggested. Suitable
nitrification inhibitors include biological nitrification
inhibitors (BNIs) such as linoleic acid, alpha-linolenic acid,
methyl p-coumarate, methyl ferulate, MHPP, Karanjin, brachialacton
or the p-benzoquinone sorgoleone (Subbarao et al., 2012, Advances
in Agronomy, 114, 249-302). Further suitable nitrification
inhibitors are synthetic chemical inhibitors such as Nitrapyrin,
dicyandiamide (DCD), 3,4-dimethyl pyrazole phosphate (DMPP),
4-amino-1,2,4-triazole hydrochloride (ATC), 1-amido-2-thiourea
(ASU), 2-amino-4-chloro-6-methylpyrimidine (AM),
5-ethoxy-3-trichloromethyl-1,2,4-thiodiazole (terrazole), or
2-sulfanilamidothiazole (ST) (Slangen and Kerkhoff, 1984,
Fertilizer research, 5(1), 1-76).
[0007] EP 0 917 526 further mentions the use of polyacids to treat
mineral fertilizers containing a nitrification inhibitor in order
to improve the fixation of the nitrification inhibitors in the
inorganic fertilizer. Moreover, the volatility of the nitrification
inhibitor can be reduced.
[0008] However, many of these inhibitors only work sub-optimal or
have undesirable side effects.
[0009] In view of this situation there is a continuous need for
compositions or mixtures that increase the health of plants.
Healthier plants are desirable since they result among other in
better crop yields and/or a better quality of the plants or crops.
Healthier plants also better resist to biotic and abiotic stress. A
better resistance to stress in turn allows reducing the quantity of
pesticides, which also helps avoiding the development of
resistances against the respective pesticides.
[0010] One object of the present invention is to provide a
composition or mixture containing a nitrification inhibitor and/or
a biopesticide which increases the health of plants, and/or
provides better crop yields and/or a better quality of the plants
or crops, and/or shows a better resistance to stress, and/or allows
the reduction of the quantity of pesticides used, and/or helps
avoiding the development of resistances against the respective
pesticides.
[0011] Another object of the present invention is to provide a
composition or mixture containing the nitrification inhibitor
(compound I) and/or a biopesticide (compound II) which--each
preferably through a synergistic action-- [0012] (i) enhances the
stability of compound I, and/or [0013] (ii) enhances the
nitrification-inhibiting effect of compound I, and/or [0014] (iii)
enhances the yield increase effect of the compound I, and/or [0015]
(iv) has a relatively long storage life, particularly before being
applied to or coated on nitrogen-containing fertilizers, and/or
[0016] (v) reduces the emission of nitrous oxide from soils, and/or
[0017] (vi) reduces the ammonia emission from soils, and/or [0018]
(vii) reduces nitrate leaching, and/or [0019] (viii) does not
adversely affect the nitrification-inhibiting effect and/or the
nitrification-inhibiting activity of the compound I, and/or [0020]
(ix) can be easily and safely packaged, transported and shipped,
even in large quantities, and/or [0021] (x) can be easily and
safely handled and applied for soil treatment, even in large
quantities, and/or [0022] (xi) improves the nutrient use
efficiency, and/or [0023] (xii) improves the delivery of the
biopesticide (compound II) to the plant, and/or [0024] (xiii)
improves the plant growth (e.g. biomass, yield, root branching and
length; compact growth in case of ornamental plants), and/or [0025]
(xiv) enables a better developed root system, a larger leaf area,
greener leaves, stronger shoots and/or [0026] (xv) improves the
plant defense of the plants, and/or [0027] (xvi) improves the plant
health of the plants, and/or [0028] (xvii) improves the quality of
the plants, and/or [0029] (xviii) improves the storage or
survivability of the biopesticide (compound II) and/or prolongs the
availability of biopesticides (compound II) to the plants, and/or
[0030] (xix) enhances the biopesticidal effect of the biopesticide
(compound II), and/or [0031] (xx) allows the reduction of the
quantity of biopesticides (compound II) used, and/or [0032] (xxi)
increase the survivability rate of seedlings, for example
transplanted seedlings, and/or [0033] (xxii) reduce or avoid
unfavorable environmental or toxicological effects whilst still
allowing effective pest control, and/or [0034] (xxiii) enable
earlier seed germination and/or blooming, and/or [0035] (xxiv) is
toxicologically unobjectionable, and/or [0036] (xxv) enables simple
handling and application of compound I and compound II.
[0037] The objects (xiii), (xiv), (xv), (xvi), (xvii) and (xxi)
particularly pertains to such plants or seedlings wherein such
plants or seedlings were treated with the mixture or composition,
or the soil in which the plants or seedlings were placed, was
subject to the application of the mixture or composition of the
present invention.
[0038] The preferred objects of the present invention are (i),
(ii), (v), (vi), (vii), (xi), (xii), (xiii), (xiv), (xv), (xvi),
(xvii), (xviii), (xix), (xx), (xxii), (xxiv), (xxv), the more
preferred objects of the present invention are (i), (ii), (v),
(vi), (vii), (xii), (xiii), (xv), (xvi), (xix), (xx), and/or
(xxii), the most preferred objects of the present invention are
(i), (ii), (v), (vii), (xvi), (xix), and/or (xxii), the
particularly preferred objects of the present invention are (ii),
(v), (vii), (xvi) and/or (xix).
[0039] The term "in a synergistic way" means that the composition
or mixture comprising the nitrification inhibitor (compound I) and
the biopesticide (compound II) can fulfil one or more of the
objects (i) to (xxiv) significantly better than the individual
compounds--i.e. compound I or compound II--alone can do, and
preferably, this better fulfillment of the objects by said
composition or mixture compared to the individual compounds is
evidenced by calculations according to Colby's formula, see Colby,
S. R. (Calculating synergistic and antagonistic responses of
herbicide Combinations", Weeds, 15, pp. 20-22, 1967).
[0040] The present invention relates to a mixture comprising as
active components [0041] 1) at least one active compound I
(nitrification inhibitor) selected from the group consisting of:
[0042] a) 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid (referred
to as "DMPSA1" in the following) and/or
2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid (referred to as
"DMPSA2" in the following), and/or a derivative thereof, and/or a
salt thereof, [0043] b) glycolic acid addition salt of 3,4-dimethyl
pyrazole (3,4-dimethyl pyrazolium glycolate, referred to as "DMPG"
in the following), and/or an isomer thereof, and/or a derivative
thereof, [0044] c) citric acid addition salt of 3,4-dimethyl
pyrazole (3,4-dimethyl pyrazolium citrate, referred to as "DMPC" in
the following), and/or an isomer thereof, and/or a derivative
thereof, [0045] d) lactic acid addition salt of 3,4-dimethyl
pyrazole (3,4-dimethyl pyrazolium lactate, referred to as "DMPL" in
the following), and/or an isomer thereof, and/or a derivative
thereof, [0046] e) mandelic acid addition salt of 3,4-dimethyl
pyrazole (3,4-dimethyl pyrazolium mandelate, referred to as "DMPM"
in the following), and/or an isomer thereof, and/or a derivative
thereof, [0047] f) 1,2,4-triazole (referred to as "TZ" in the
following), and/or a derivative thereof, and/or a salt thereof,
[0048] g) 4-Chloro-3-methylpyrazole (referred to as "CIMP" in the
following), and/or an isomer thereof, and/or a derivative thereof,
and/or a salt thereof, [0049] h)
N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)acetamide, and/or an isomer
thereof, and/or a derivative thereof, and/or a salt thereof, [0050]
i) N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)formamide, and/or an
isomer thereof, and/or a derivative thereof, and/or a salt thereof,
[0051] j) N-((3(5),4-dimethyl pyrazole-1-yl)methyl)formamide,
and/or an isomer thereof, and/or a derivative thereof, and/or a
salt thereof, [0052] k)
N-((4-chloro-3(5)-methyl-pyrazole-1-yl)methyl)formamide, and/or an
isomer thereof, and/or a derivative thereof, and/or a salt thereof,
[0053] l) a reaction adduct of dicyandiamide, urea and
formaldehyde, or a triazonyl-formaldehyde-dicyandiamide adduct,
[0054] m) 2-cyano-1-((4-oxo-1,3,5-triazinan-1-yl)methyl)guanidine,
[0055] n) 1-((2-cyanoguanidino)methyl)urea, [0056] o)
2-cyano-1-((2-cyanoguanidino)methyl)guanidine, [0057] p)
2-chloro-6-(trichloromethyl)-pyridine (nitrapyrin or N-serve),
[0058] q) dicyandiamide (DCD, DIDIN), [0059] r) 3,4-dimethyl
pyrazole phosphate, and/or 4,5-dimethyl pyrazole phosphate (DMPP,
ENTEC), and/or an isomer thereof, and/or a derivative thereof,
[0060] s) 3,4-dimethylpyrazole, and/or 4,5-dimethylpyrazole (DMP),
and/or an isomer thereof, and/or a derivative thereof, and/or a
salt thereof, and/or an acid addition salt thereof, [0061] t)
ammoniumthiosulfate (ATU), [0062] u) neem, and/or products based on
ingredients of neem, [0063] v) linoleic acid, [0064] w)
alpha-linolenic acid, [0065] x) methyl p-coumarate, [0066] y)
methyl ferulate, [0067] z) methyl 3-(4-hydroxyphenyl) propionate
(MHPP), [0068] aa) Karanjin, [0069] bb) brachialacton, [0070] cc)
p-benzoquinone sorgoleone, [0071] dd) 4-amino-1,2,4-triazole
hydrochloride (ATC), [0072] ee) 1-amido-2-thiourea (ASU), [0073]
ff) 2-amino-4-chloro-6-methylpyrimidine (AM), [0074] gg)
2-mercapto-benzothiazole (MBT), [0075] hh)
5-ethoxy-3-trichloromethyl-1,2,4-thiodiazole (terrazole,
etridiazole), [0076] ii) 2-sulfanilamidothiazole (ST), [0077] jj)
3-methylpyrazol (3-MP), [0078] kk) 1,2,4-triazol thiourea (TU),
[0079] ll) cyan amide, [0080] mm) melamine, [0081] nn)zeolite
powder, [0082] oo) catechol, [0083] pp) benzoquinone, [0084]
qq)sodium tetra borate, [0085] rr) allylthiourea, [0086] ss)
chlorate salts, and [0087] tt) zinc sulfate; and [0088] 2) at least
one active compound II (biopesticide) selected from groups L1) to
L6): [0089] L1) Microbial pesticides with fungicidal, bactericidal,
viricidal and/or plant defense activator activity: Ampelomyces
quisqualis, Aspergillus flavus, Aureobasidium pullulans, Bacillus
altitudinis, Bacillus amyloliquefaciens, Bacillus licheniformis,
Bacillus megaterium, Bacillus mojavensis, Bacillus mycoides,
Bacillus pumilus, Bacillus simplex, Bacillus solisalsi, Bacillus
subtilis, Bacillus subtilis var. amyloliquefaciens, Candida
oleophila, Candida saitoana, Clavibacter michiganensis
(bacteriophages), Coniothyrium minitans, Cryphonectria parasitica,
Cryptococcus albidus, Dllophosphora alopecuri, Fusarium oxysporum,
Clonostachys rosea f. catenulata (also named Gliocladium
catenulatum), Gliocladium roseum, Lysobacter antibioticus,
Lysobacter enzymogenes, Metschnikowia fructicola, Microdochium
dimerum, Microsphaeropsis ochracea, Muscodor albus, Paenibacillus
alvei, Paenibacillus epiphyticus, Paenibacillus polymyxa,
Paenibacillus agglomerans, Pantoea vagans, Penicillium bilaiae,
Phlebiopsis gigantea, Pseudomonas chlororaphis, Pseudomonas
fluorescens, Pseudomonas putida, Pseudozyma flocculosa, Pichia
anomala, Pythium oligandrum, Sphaerodes mycoparasitica,
Streptomyces griseoviridis, Streptomyces lydicus, Streptomyces
violaceusniger, Talaromyces flavus, Trichoderma asperellum,
Trichoderma atroviride, Trichoderma asperelloides, Trichoderma
fertile, Trichoderma gamsii, Trichoderma harmatum, Trichoderma
harzianum, Trichoderma polysporum, Trichoderma stromaticum,
Trichoderma virens, Trichoderma viride, Typhula phacorrhiza,
Ulocladium oudemansii, Verticillium dahlia, zucchini yellow mosaic
virus (avirulent strain); [0090] L2) Biochemical pesticides with
fungicidal, bactericidal, viricidal and/or plant defense activator
activity: chitosan (hydrolysate), fusaricidins, paeniserines,
paeniprolixines, harpin protein, laminarin, Menhaden fish oil,
natamycin, Plum pox virus coat protein, potassium or sodium
bicarbonate, Reynoutria sachalinensis extract, salicylic acid, tea
tree oil (Melaleuca alternifolla extract); [0091] L3) Microbial
pesticides with insecticidal, acaricidal, molluscidal and/or
nematicidal activity: Agrobacterium radiobacter, Bacillus cereus,
Bacillus firmus, Bacillus subtilis, Bacillus licheniformis,
Bacillus thuringiensis, Bacillus thuringiensis ssp. aizawai,
Bacillus thuringiensis ssp. israelensis, Bacillus thuringiensis
ssp. galleriae, Bacillus thuringiensis ssp. kurstaki, Bacillus
thuringiensis ssp. tenebrionis, Beauveria bassiana, Beauveria
brongniartil, Burkhoideria rinojensis, Chromobacterium subtsugae,
Cydia pomonella granulovirus (CpGV), Cryptophlebia leucotreta
granulovirus (CrleGV), Flavobacterium spp., Helicoverpa armigera
nucleopolyhedrovirus (HearNPV), Heterorhabditis bacteriophora,
Isaria fumosorosea, Lecanicillium longisporum, Lecanicillium
muscarium, Metarhizium anisopliae, Metarhizium anisopliae var.
anisopliae, Metarhizium anisopliae var. acridum, Nomuraea rileyi,
Paecilomyces lilacinus, Paenibacillus popilliae, Pasteuria
nishizawae, Pasteuria penetrans, Pasteuria ramosa, Pasteuria
thornea, Pasteuria usgae, Phasmarhabditis hermaphrodita,
Pseudomonas fluorescens, Spodoptera littoralis nucleopolyhedrovirus
(SpliNPV), Steinernema carpocapsae, Steinernema feltiae, Stelnemema
kraussei, Stelnemema riobrave, Streptomyces galbus, Streptomyces
microflavus, Paecilomyces lilacinus, [0092] L4) Biochemical
pesticides with insecticidal, acaricidal, molluscidal, pheromone
and/or nematicidal activity: L-carvone, citral,
(E,Z)-7,9-dodecadien-1-yl acetate, ethyl formate, (E,Z)-2,4-ethyl
decadienoate (pear ester), (Z,Z,E)-7,11,13-hexadecatrienal, heptyl
butyrate, isopropyl myristate, lavanulyl senecioate, cis-jasmone,
2-methyl 1-butanol, methyl eugenol, methyl jasmonate,
(E,Z)-2,13-octadecadien-1-ol, (E,Z)-2,13-octadecadien-1-ol acetate,
(E,Z)-3,13-octadecadien-1-ol, R-1-octen-3-ol, pentatermanone,
potassium silicate, sorbitol actanoate,
(E,Z,Z)-3,8,11-tetradecatrienyl acetate,
(Z,E)-9,12-tetradecadien-1-yl acetate, Z-7-tetradecen-2-one,
Z-9-tetradecen-1-yl acetate, Z-11-tetradecenal,
Z-11-tetradecen-1-ol, Acacia negra extract, extract of grapefruit
seeds and pulp, Chenopodium ambrosioides extract, Catnip oil, Neem
oil, Quillay extract, Tagetes oil; [0093] L5) Microbial pesticides
with plant stress reducing, plant growth regulator, plant growth
promoting and/or yield enhancing activity: Azospirillum amazonense,
Azospialum brasilense, Azospirillum lipoferum, Azospirillum
irakense, Azospirillum halopraeferens, Bradyrhizobium elkanii;
Bradyrhizobium japonicum, Bradyrhizobium spp., Bradyrhizobium
liaoningense, Bradyrhizobium Delftia acidovorans, Glomus
intraradices, Mesorhizobium spp., Mesorhizobium ciceri, Rhizobium
leguminosarum bv. phaseoli, Rhizobium leguminosarum bv. trifolii,
Rhizobium leguminosarum bv. viciae, Rhizobium Sinorhizobium
meliloti, Sinorhizobium medicae; [0094] L6) Biochemical pesticides
with plant stress reducing, plant growth regulator and/or plant
yield enhancing activity: abscisic acid, aluminium silicate
(kaolin), 3-decen-2-one, formononectin, genistein, hesperetin,
homobrassinolide, humates, methyl jasmonate, cis-jasmone,
lysophosphatidyl ethanlamine, naringenin, polymeric polyhydroxy
acid, salicylic acid, Ascophyllum nodosum (Norwegian kelp, Brown
kelp) extract and Ecklonia maxima (kelp) extract, zeolite
(aluminosilicate), grape seed extract.
[0095] The above mixture of the present invention also includes
kit-of-parts comprising a nitrification inhibitor (compound I) and
a biopesticide (compound II). Here, the term "kit-of-parts" is to
be understood to denote a kit comprising at least two separate
parts wherein each of the parts can be independently removed from
the kit. A kit includes a box, a tool, a vessel, a container, a bag
or any kit-like equipment. Also a kit whose separate parts are only
together in this one kit for a extremely short period of time are
regarded as kit-of-parts. Kit-of-parts are useful for the combined
application (of the contents) of the separate parts of the kit.
[0096] The present invention also relates to an agrochemical
composition, comprising an auxiliary and a mixture comprising as
active components at least one compound I and at least one compound
II.
[0097] The present invention also relates to the use of a mixture
or an agrochemical composition according to the invention for
nitrification inhibition and/or for increasing the health of a
plant and/or for plant growth regulation.
[0098] The present invention also relates to a method for
controlling phytopathogenic harmful fungi, comprising treating the
fungi, their habitat or the seed, the soil or the plants to be
protected against fungal attack with an effective amount of a
mixture or of an agrochemical composition according to the
invention.
[0099] The present invention also relates to a method for
controlling phytopathogenic harmful insects, comprising treating
the insects, their habitat or the seed, the soil or the plants to
be protected against insect attack with an effective amount of a
mixture or of an agrochemical composition according to the
invention.
[0100] The present invention also relates to a method for
increasing the health of a plant, comprising treating the plant or
the plant propagation material or the soil where the plants are to
grow with an effective amount of the mixture or of an agrochemical
composition according to the invention.
[0101] The present invention also relates to plant propagation
material, comprising a mixture or an agrochemical composition
according to the invention in an amount of from 0.1 to 10 kg active
substances per 100 kg of seed.
[0102] A "pesticide" is generally a chemical or biological agent
(such as a virus, bacterium, antimicrobial or disinfectant) that
through its effect deters, incapacitates, kills or otherwise
discourages pests. Target pests can include insects, plant
pathogens, weeds, mollusks, birds, mammals, fish, nematodes
(roundworms), and microbes that destroy property, cause nuisance,
spread disease or are vectors for disease. The term "pesticide"
includes also plant growth regulators that alter the expected
growth, flowering, or reproduction rate of plants; defoliants that
cause leaves or other foliage to drop from a plant, usually to
facilitate harvest; desiccants that promote drying of living
tissues, such as unwanted plant tops; plant activators that
activate plant physiology for defense of against certain pests;
safeners that reduce unwanted herbicidal action of pesticides on
crop plants; and plant growth promoters that affect plant
physiology e.g. to increase plant growth, biomass, yield or any
other quality parameter of the harvestable goods of a crop
plant.
[0103] Biopesticides have been defined as a form of pesticides
based on micro-organisms (bacteria, fungi, viruses, nematodes,
etc.) or natural products (compounds, such as metabolites,
proteins, or extracts from biological or other natural sources)
(U.S. Environmental Protection Agency:
http://www.epa.gov/pesticides/biopesticides/). Biopesticides fall
into two major classes, microbial and biochemical pesticides:
(1) Microbial pesticides consist of bacteria, fungi or viruses (and
often include the metabolites that bacteria and fungi produce).
Entomopathogenic nematodes are also classified as microbial
pesticides, even though they are multi-cellular. (2) Biochemical
pesticides are naturally occurring substances or
structurally-similar and functionally identical to a
naturally-occurring substance and extracts from biological sources
that control pests or provide other crop protection uses as defined
below, but have non-toxic mode of actions (such as growth or
developmental regulation, attractants, repellents or defence
activators (e.g. induced resistance) and are relatively non-toxic
to mammals.
[0104] Biopesticides for use against crop diseases have already
established themselves on a variety of crops. For example,
biopesticides already play an important role in controlling downy
mildew diseases. Their benefits include: a 0-Day Pre-Harvest
Interval, the ability to use under moderate to severe disease
pressure, and the ability to use in mixture or in a rotational
program with other registered pesticides.
[0105] A major growth area for biopesticides is in the area of seed
treatments and soil amendments. Biopesticidal seed treatments are
e.g. used to control soil borne fungal pathogens that cause seed
rots, damping-off, root rot and seedling blights. They can also be
used to control internal seed borne fungal pathogens as well as
fungal pathogens that are on the surface of the seed. Many
biopesticidal products also show capacities to stimulate plant host
defenses and other physiological processes that can make treated
crops more resistant to a variety of biotic and abiotic stresses or
can regulate plant growth. Many biopesticidal products also show
capacities to stimulate plant health, plant growth and/or yield
enhancing activity.
[0106] The term "plant health" or "health of a plant" as used
herein is intended to mean a condition of the plant which is
determined by several aspects alone or in combination with each
other. One indicator (indicator 1) for the condition of the plant
is the crop yield. "Crop" and "fruit" are to be understood as any
plant product which is further utilized after harvesting, e.g.
fruits in the proper sense, vegetables, nuts, grains, seeds, wood
(e.g. in the case of silviculture plants), flowers (e.g. in the
case of gardening plants, ornamentals) etc., that is anything of
economic value that is produced by the plant. Another indicator
(indicator 2) for the condition of the plant is the plant vigor.
The plant vigor becomes manifest in several aspects, too, some of
which are visual appearance, e.g. leaf color, fruit color and
aspect, amount of dead basal leaves and/or extent of leaf blades,
plant weight, plant height, extent of plant verse (lodging),
number, strong ness and productivity of tillers, panicles' length,
extent of root system, strongness of roots, extent of nodulation,
in particular of rhizobial nodulation, point of time of
germination, emergence, flowering, grain maturity and/or
senescence, protein content, sugar content and the like. Another
indicator (indicator 3) for an increase of a plant's health is the
reduction of biotic or abiotic stress factors. The three above
mentioned indicators for the health condition of a plant may be
interdependent and may result from each other. For example, a
reduction of biotic or abiotic stress may lead to a better plant
vigor, e.g. to better and bigger crops, and thus to an increased
yield. Biotic stress, especially over longer terms, can have
harmful effects on plants. The term "biotic stress" as used in the
context of the present invention refers in particular to stress
caused by living organisms. As a result, the quantity and the
quality of the stressed plants, their crops and fruits decrease. As
far as quality is concerned, reproductive development is usually
severely affected with consequences on the crops which are
important for fruits or seeds. Growth may be slowed by the
stresses; polysaccharide synthesis, both structural and storage,
may be reduced or modified: these effects may lead to a decrease in
biomass and to changes in the nutritional value of the product.
Abiotic stress includes drought, cold, increased UV, increased
heat, or other changes in the environment of the plant, that leads
to sub-optimal growth conditions. The term "increased yield" of a
plant as used herein means that the yield of a product of the
respective plant is increased by a measurable amount over the yield
of the same product of the plant produced under the same
conditions, but without the application of the composition of the
invention. According to the present invention, it is preferred that
the yield is increased by at least 2%, more preferably by at least
4%, most preferably at least 7%, particularly preferably at least
10%, more particularly preferably by at least 15%, most
particularly preferably by at least 20%, particularly more
preferably by at least 25%, particularly most preferably by at
least 30%, particularly by at least 35%, especially more preferably
by at least 40%, especially most preferably by at least 45%,
especially by at least 50%, in particular preferably by at least
55%, in particular more preferably by at least 60%, in particular
most preferably by at least 65%, in particular by at least 70%, for
example by at least 75%. According to the present invention, it is
preferred that the yield is increased--compared to the situation in
which only the individual compound I or the individual compound II
is used--by at least 1%, more preferably by at least 2%, most
preferably at least 3%, particularly preferably at least 4%, more
particularly preferably by at least 5%, most particularly
preferably by at least 6%, particularly more preferably by at least
7%, particularly most preferably by at least 8%, particularly by at
least 10%, especially more preferably by at least 12%, especially
most preferably by at least 14%, especially by at least 16%, in
particular preferably by at least 18%. An increased yield may, for
example, be due to a reduction of nitrification and a corresponding
improvement of uptake of nitrogen nutrients. The term "improved
plant vigor" as used herein means that certain crop characteristics
are increased or improved by a measurable or noticeable amount over
the same factor of the plant produced under the same conditions,
but without the application of the composition of the present
invention. Improved plant vigor can be characterized, among others,
by following improved properties of a plant: [0107] (a) improved
vitality of the plant, [0108] (b) improved quality of the plant
and/or of the plant products, e.g. [0109] (b) enhanced protein
content, [0110] (c) improved visual appearance, [0111] (d) delay of
senescence, [0112] (e) enhanced root growth and/or more developed
root system (e.g. determined by the dry mass of the root), [0113]
(f) enhanced nodulation, in particular rhizobial nodulation, [0114]
(g) longer panicles, [0115] (h) bigger leaf blade, [0116] (i) less
dead basal leaves, [0117] (j) increased chlorophyll content [0118]
(k) prolonged photosynthetically active period [0119] (l) improved
nitrogen-supply within the plant [0120] (m) improved water use
efficiency
[0121] The improvement of the plant vigor according to the present
invention particularly means that the improvement of anyone or
several or all of the above mentioned plant characteristics are
improved. It further means that if not all of the above
characteristics are improved, those which are not improved are not
worsened as compared to plants which were not treated according to
the invention or are at least not worsened to such an extent that
the negative effect exceeds the positive effect of the improved
characteristic (i.e. there is always an overall positive effect
which preferably results in an improved crop yield). An improved
plant vigor may, for example, be due to a reduction of
nitrification and, e.g. a regulation of plant growth.
[0122] However, biopesticides under certain conditions can also
have disadvantages such as high specificity: which may require an
exact identification of the pest/pathogen and the use of multiple
products to be used, slow speed of action (thus making them
unsuitable if a pest outbreak is an immediate threat to a crop),
variable efficacy due to the influences of various biotic and
abiotic factors (since biopesticides are usually living organisms,
which bring about pest/pathogen control by multiplying within the
target insect pest/pathogen) and resistance development.
[0123] Practical agricultural experience has shown that the
repeated and exclusive application of an individual active
component in the control of harmful fungi, insects or other pests
leads in many cases to a rapid selection of those fungus strains or
pest isolates which have developed natural or adapted resistance
against the active component in question. Effective control of
these fungi, insects or other pests with the active component in
question is then no longer possible.
[0124] Another typical problem arising in the field of pest control
lies in the need to reduce the dosage rates of the active
ingredient to reduce or avoid unfavorable environmental or
toxicological effects whilst still allowing effective pest
control.
[0125] It is an object of the present invention to overcome the
abovementioned disadvantages and to provide, with a view to
effective resistance management and effective control of
phytopathogenic harmful fungi, insects or other pests or to
effective plant growth regulation, at application rates which are
as low as possible, compositions which, at a reduced total amount
of active compounds applied, have improved activity against the
harmful fungi, insects or other pests or improved plant growth
regulating activity (synergistic mixtures) and a broadened activity
spectrum, in particular for certain indications.
[0126] This is particularly visible if application rates for the
beforementioned mixtures of pesticides are used where the
individual components show no or virtually no activity. The
invention can also result in an advantageous behavior during
formulation or during use, for example during grinding, sieving,
emulsifying, dissolving or dispensing; improved storage stability
and light stability, advantageous residue formation, improved
toxicological or ecotoxicological behaviour, improved properties of
the plant, for example better growth, increased harvest yields, a
better developed root system, a larger leaf area, greener leaves,
stronger shoots, less seed required, lower phytotoxicity,
mobilization of the defense system of the plant, good compatibility
with plants. Moreover, even an enhanced systemic action of the
pesticides as defined herein and/or a persistency of the
fungicidal, insecticidal, acaricidal, nematicidal action and/or
plant growth regulating activity are expected.
[0127] It was therefore also an object of the present invention to
provide mixtures which solve the problems of reducing the dosage
rate, and/or enhancing the spectrum of activity, and/or combining
knock-down activity with prolonged control, and/or improving
resistance management and/or promoting (increasing) the health of
plants, and/or facilitating application on the plants or on the
soil.
[0128] We have accordingly found that this object is achieved by
the mixtures and compositions defined herein.
[0129] Any reference to "compound I" refers to compound I as such,
or an agriculturally useful salt thereof.
[0130] Any reference to "compound III" refers to compound III as
such, or an agriculturally useful salt thereof.
[0131] Agriculturally useful salts of the active compounds I, II
and III encompass especially the salts of those cations or the acid
addition salts of those acids whose cations and anions,
respectively, have no adverse effect on the fungicidal action of
the active compounds. Suitable cations are thus in particular the
ions of the alkali metals, preferably sodium and potassium, of the
alkaline earth metals, preferably calcium, magnesium and barium, of
the transition metals, preferably manganese, copper, zinc and iron,
and also the ammonium ion which, if desired, may carry 1 to 4
C.sub.1-C.sub.4-alkyl substituents and/or one phenyl or benzyl
substituent, preferably di isopropylammonium, tetramethylammonium,
tetrabutylammonium, trimethylbenzylammonium, furthermore
phosphonium ions, sulfonium ions, preferably
tri(C.sub.1-C.sub.4-alkyl)sulfonium, and sulfoxonium ions,
preferably tri(C.sub.1-C.sub.4-alkyl)sulfoxonium. Anions of useful
acid addition salts are primarily chloride, bromide, fluoride,
hydrogensulfate, sulfate, dihydrogenphosphate, hydrogenphosphate,
phosphate, nitrate, bicarbonate, carbonate, hexafluorosilicate,
hexafluorophosphate, benzoate, and the anions of
C.sub.1-C.sub.4-alkanoic acids, preferably formate, acetate,
propionate and butyrate. They can be formed by reacting a compound
I with an acid of the corresponding anion, preferably of
hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid
or nitric acid.
[0132] The scope of the present invention includes mixtures of the
(R)- and (S)-isomers and the racemates of compounds I and/or II
and/or III having one or more chiral centers. As a result of
hindered rotation of asymmetrically substituted groups, atrope
isomers of active compounds I and/or II and/or III may be present.
They also form part of the subject matter of the invention.
[0133] Within compound II, the microbial pesticides of the groups
L1, L3 and L5 embrace not only the isolated, pure cultures as
defined herein, but also their cell-free extract having pesticidal
activity, preferably a ketone-based extract, their suspension in a
whole broth culture or as a metabolite-containing supernatant or a
purified metabolite obtained from a whole broth culture of the
microorganism or microorganism strain.
[0134] As used herein, "whole culture broth" refers to a liquid
culture of a microorganism containing vegetative cells and/or
spores suspended in the culture medium and optionally metabolites
produced by the respective microorganism.
[0135] As used herein, "culture medium", refers to a medium
obtainable by culturing the microorganism in said medium,
preferably a liquid broth, and remaining when cells grown in the
medium are removed, e.g. the supernatant remaining when cells grown
in a liquid broth are removed by centrifugation, filtration,
sedimentation, or other means well known in the art; comprising
e.g. metabolites produced by the respective microorganism and
secreted into the culture medium. The "culture medium" sometimes
also referred to as "supernatant" can be obtained e.g. by
centrifugation at temperatures of about 2 to 30.degree. C. (more
preferably at temperatures of 4 to 20.degree. C.) for about 10 to
60 min (more preferably about 15 to 30 min) at about 5,000 to
20,000.times.g (more preferably at about 15,000.times.g).
[0136] As used herein, "cell-free extract" refers to an extract of
the vegetative cells, spores and/or the whole culture broth of a
microorganism comprising cellular metabolites produced by the
respective microorganism obtainable by cell disruption methods
known in the art such as solvent-based (e.g. organic solvents such
as alcohols sometimes in combination with suitable salts),
temperature-based, application of shear forces, cell disruption
with an ultrasonicator. The desired extract may be concentrated by
conventional concentration techniques such as drying, evaporation,
and centrifugation or alike. Certain washing steps using organic
solvents and/or water-based media may also be applied to the crude
extract preferably prior to use.
[0137] As used herein, the term "metabolite" refers to any
component, compound, substance or byproduct (including but not
limited to small molecule secondary metabolites, polyketides, fatty
acid synthase products, non-ribosomal peptides, ribosomal peptides,
proteins and enzymes) produced by a microorganism (such as fungi
and bacteria, in particular the strains of the invention) that has
any beneficial effect as described herein such as pesticidal
activity or improvement of plant growth, water use efficiency of
the plant, plant health, plant appearance, or the population of
beneficial microorganisms in the soil around the plant activity
herein.
[0138] As used herein, "isolate" refers to a pure microbial culture
separated from its natural origin, such an isolate obtained by
culturing a single microbial colony. An isolate is a pure culture
derived from a heterogeneous, wild population of
microorganisms.
[0139] As used herein, "strain" refers to isolate or a group of
isolates exhibiting phenotypic and/or genotypic traits belonging to
the same lineage, distinct from those of other isolates or strains
of the same species.
[0140] The term "mutant" refers a microorganism obtained by direct
mutant selection but also includes microorganisms that have been
further mutagenized or otherwise manipulated (e.g. via the
introduction of a plasmid). Accordingly, embodiments include
mutants, variants, and or derivatives of the respective
microorganism, both naturally occurring and artificially induced
mutants. For example, mutants may be induced by subjecting the
microorganism to known mutagens, such as X-ray, UV radiation or
N-methyl-nitrosoguanidine, using conventional methods. Subsequent
to said treatments a screening for mutant strains showing the
desired characteristics may be performed.
[0141] Mutant strains may be obtained by any methods known in the
art such as direct mutant selection, chemical mutagenesis or
genetic manipulation (e.g., via the introduction of a plasmid). For
example, such mutants are obtainable by applying a known mutagen,
such as X-ray, UV radiation or N-methyl-nitrosoguanidine.
Subsequent to said treatments a screening for mutant strains
showing the desired characteristics may be performed.
[0142] In general, the term "nematode" comprises eggs, larvae,
juvenile and mature forms of said organism. Thus, in one
embodiment, said organisms are comprised in form of eggs, larvae,
juvenile or mature form in a formulation, e.g., a solo- or
combined-formulation.
[0143] According to one embodiment, compound II is a cell-free
extract of a microbial pesticide. According to a further
embodiment, compound II is a mutant of a microbial pesticide having
pesticidal activity and producing at least one pesticidal
metabolite. According to a further embodiment, the mutant of the
microbial pesticide is obtained by direct mutant selection
optionally after being subjected to mutagens. According to a
further embodiment, the microbial pesticide is in a whole browth.
According to a further embodiment, the microbial pesticide is in a
dormant form. According to a further embodiment, the microbial
pesticide is in the form of spores. According to a further
embodiment, the microbial pesticide is in the form of condiospores
or chlamydospores.
[0144] "Chlamydospores" are thick-walled big resting spore of
several kinds of fungi. It is the life-stage which survives in
unfavourable conditions, such as dry or hot seasons, which makes
them being a stable and storable dormant life stage an especially
suitable use form of a biopesticide. "Conidiospores" (also called
conidia) are asexual spores that are generated through mitosis.
[0145] The microbial pesticides may be cultivated using media and
fermentation techniques known in the art. In liquid culture,
condiospores and chlamydospores can be produced. In large liquid
cultures, aeriation may be necessary. The bacterial cells
(vegatitive cells and spores) can be washed and concentrated (e.g.
by centrifugation at room temperature for about 15 min at
7000.times. g). To produce a dry formulation, bacterial cells,
preferably spores were suspended in a suitable dry carrier (e.g.
clay). To produce a liquid formulation, cells, preferably spores,
can be re-suspended in a suitable liquid carrier (e.g. water-based)
to the desired spore density. The spore density number of spores
per mL can be determined by identifying the number of
colony-forming units (CFU) on agar medium e.g. potato dextrose agar
after incubation for several days.
[0146] Regarding the Compounds I, the compound and preparation of
DMPSA1 or DMPSA2 have been described for example in WO 2015/086823
A2. DMPSA1 is described in the formula I below, and DMPSA2 is
described in formula II below. The compound and preparation of
DMPG, DMPC, DMPL, and DMPM have been described for example in AU
2015/227487 B1. The compound and preparation of
N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)acetamide have been
described for example in DE 102013022031 B3, The compound and
preparation of N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)formamide,
N-((4-chloro-3(5)-methyl-pyrazole-1-yl)methyl)formamide, and
N-((3(5),4-dimethylpyrazole-1-yl)methyl)formamide have been
described for example in EP 2785697 B1. A reaction adduct of
dicyandiamide, urea and formaldehyde, a
triazonyl-formaldehyde-dicyandiamide adduct,
2-cyano-1-((4-oxo-1,3,5-triazinan-1-yl)methyl)guanidine,
1-((2-cyanoguanidino)methyl)urea, and
2-cyano-1-((2-cyanoguanidino)methyl)guanidine have been described
in US 2016/0060184 A1.
2-cyano-1-((4-oxo-1,3,5-triazinan-1-yl)methyl)guanidine has the
structure as described in formula III below, and
1-((2-cyanoguanidino)methyl)urea has the structure as described in
formula IV below, and 2-cyano-1-((2-cyanoguanidino)methyl)guanidine
has the structure as described in formula V below.
##STR00001##
[0147] Compounds II (biopesticides from group L)), their
preparation and their pesticidal activity e.g. against harmful
fungi or insects are known (e-Pesticide Manual V 5.2 (ISBN 978 1
901396 85 0) (2008-2011);
http://www.epa.gov/opp00001/biopesticides/, see product lists
therein; http://www.omri.org/omri-lists, see lists therein;
Bio-Pesticides Database BPDB http://sitem.herts.ac.uk/aeru/bpdb/,
see A to Z link therein).
[0148] Compounds II, their preparation and their activity e. g.
against harmful fungi is known (cf.:
http://www.alanwood.net/pesticides/); these substances are
commercially available. The compounds described by IUPAC
nomenclature, their preparation and their pesticidal activity are
also known (cf. Can. J. Plant Sci. 48(6), 587-94, 1968; EP-A 141
317; EP-A 152 031; EP-A 226 917; EP-A 243 970; EP-A 256 503; EP-A
428 941; EP-A 532 022; EP-A 1 028 125; EP-A 1 035 122; EP-A 1 201
648; EP-A 1 122 244, JP 2002316902; DE 19650197; DE 10021412; DE
102005009458; U.S. Pat. Nos. 3,296,272; 3,325,503; WO 98/46608; WO
99/14187; WO 99/24413; WO 99/27783; WO 00/29404; WO 00/46148; WO
00/65913; WO 01/54501; WO 01/56358; WO 02/22583; WO 02/40431; WO
03/10149; WO 03/11853; WO 03/14103; WO 03/16286; WO 03/53145; WO
03/61388; WO 03/66609; WO 03/74491; WO 04/49804; WO 04/83193; WO
05/120234; WO 05/123689; WO 05/123690; WO 05/63721; WO 05/87772; WO
05/87773; WO 06/15866; WO 06/87325; WO 06/87343; WO 07/82098; WO
07/90624, WO 10/139271, WO 11/028657, WO 12/168188, WO 07/006670,
WO 11/77514; WO 13/047749, WO 10/069882, WO 13/047441, WO 03/16303,
WO 09/90181, WO 13/007767, WO 13/010862, WO 13/127704, WO
13/024009, WO 13/24010, WO 13/047441, WO 13/162072, WO 13/092224,
WO 11/135833, CN 1907024, CN 1456054, CN 103387541, CN 1309897, WO
12/84812, CN 1907024, WO 09094442, WO 14/60177, WO 13/116251, WO
08/013622, WO 15/65922, WO 94/01546, EP 2865265, WO 07/129454, WO
12/165511, WO 11/081174, WO 13/47441).
[0149] In one preferred embodiment, the present invention relates
to mixtures comprising at least one active compound I, wherein the
active compound I is 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid
(DMPSA1) and/or 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid
(DMPSA2), and/or a derivative thereof, and/or a salt thereof, more
preferably DMPSA1 and/or DMPSA2, most preferably DMPSA1.
[0150] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is a salt of DMPSA1 and/or DMPSA2,
more preferably an alkali salt, an earth alkali salt, or an
ammonium salt of DMPSA1 and/or DMPSA2, most preferably a potassium
salt, sodium salt, magnesium salt, or an ammonium salt of DMPSA1
and/or DMPSA2, particularly a potassium salt of DMPSA1 and/or
DMPSA2.
[0151] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is an alkali salt of DMPSA1 and/or
DMPSA2.
[0152] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is an earth alkali salt of DMPSA1
and/or DMPSA2.
[0153] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is an ammonium salt of DMPSA1 and/or
DMPSA2.
[0154] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is a sodium salt of DMPSA1 and/or
DMPSA2.
[0155] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is a magnesium salt of DMPSA1 and/or
DMPSA2.
[0156] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is the glycolic acid addition salt of
3,4-dimethyl pyrazole (3,4-dimethyl pyrazolium glycolate, referred
to as "DMPG" in the following), and/or an isomer thereof, and/or a
derivative thereof, most preferably DMPG.
[0157] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is the citric acid addition salt of
3,4-dimethyl pyrazole (3,4-dimethyl pyrazolium citrate, referred to
as "DMPC" in the following), and/or an isomer thereof, and/or a
derivative thereof, most preferably DMPC.
[0158] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is the lactic acid addition salt of
3,4-dimethyl pyrazole (3,4-dimethyl pyrazolium lactate, referred to
as "DMPL" in the following), and/or an isomer thereof, and/or a
derivative thereof, most preferably DMPL.
[0159] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is the mandelic acid addition salt of
3,4-dimethyl pyrazole (3,4-dimethyl pyrazolium mandelate, referred
to as "DMPM" in the following), and/or an isomer thereof, and/or a
derivative thereof, most preferably DMPM.
[0160] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is 1,2,4-triazole (referred to as
"TZ" in the following), and/or a derivative thereof, and/or a salt
thereof, most preferably TZ.
[0161] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is 4-Chloro-3-methylpyrazole
(referred to as "CIMP" in the following), and/or an isomer thereof,
and/or a derivative thereof, and/or a salt thereof, most preferably
CIMP.
[0162] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is
N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)acetamide, and/or an isomer
thereof, and/or a derivative thereof, and/or a salt thereof, most
preferably N-((3-methyl-1H-pyrazole-1-yl)methyl)acetamide, and/or
N-((5-methyl-1H-pyrazole-1-yl)methyl)acetamide.
[0163] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is
N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)formamide, and/or an isomer
thereof, and/or a derivative thereof, and/or a salt thereof, most
preferably N-((3-methyl-1H-pyrazole-1-yl)methyl)formamide, and/or
N-((5-methyl-1H-pyrazole-1-yl)methyl)formamide.
[0164] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is
N-((3(5),4-dimethylpyrazole-1-yl)methyl)formamide, and/or an isomer
thereof, and/or a derivative thereof, and/or a salt thereof, most
preferably N-((3,4-dimethyl-1H-pyrazole-1-yl)methyl)formamide,
and/or N-((4,5-dimethyl-1H-pyrazole-1-yl)methyl)formamide.
[0165] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is
N-((4-chloro-3(5)-methyl-pyrazole-1-yl)methyl)formamide, and/or an
isomer thereof, and/or a derivative thereof, and/or a salt thereof,
most preferably
N-((4-chloro-3-methyl-pyrazole-1-yl)methyl)formamide, and/or
N-((4-chloro-5-methyl-pyrazole-1-yl)methyl)formamide.
[0166] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is a reaction adduct of
dicyandiamide, urea and formaldehyde, preferably a reaction adduct
of dicyandiamide, urea and formaldehyde as described in US
2016/0060184 A1.
[0167] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is a
triazonyl-formaldehyde-dicyandiamide adducte, preferably a
triazonyl-formaldehyde-dicyandiamide adduct as described in US
2016/0060184 A1.
[0168] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is
2-cyano-1-((4-oxo-1,3,5-triazinan-1-yl)methyl)guanidine.
[0169] In another preferred embodiment, the present invention
relates to mixtures comprising at least one active compound I,
wherein the active compound I is
1-((2-cyanoguanidino)methyl)urea.
[0170] Particularly preferred are mixtures wherein compound I is
selected from the group consisting of compounds I.A to I.AU: [0171]
I.A: 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid (DMPSA1) and/or
2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid (DMPSA2), [0172] I.B:
a salt of DMPSA1 and/or DMPSA2, [0173] I.C: a potassium salt of
DMPSA1 and/or DMPSA2, [0174] I.D: an ammonium salt of DMPSA1 and/or
DMPSA2, [0175] I.E a sodium salt of DMPSA1 and/or DMPSA2, [0176]
I.F: 3,4-dimethyl pyrazolium glycolate (DMPG), [0177] I.G:
3,4-dimethyl pyrazolium citrate (DMPC), [0178] I.H: 3,4-dimethyl
pyrazolium lactate (DMPL), [0179] I.J: 3,4-dimethyl pyrazolium
lactate (DMPM), [0180] I.K: 1,2,4-triazole (TZ), [0181] I.L:
4-Chloro-3-methylpyrazole (CIMP), [0182] I.M
N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)acetamide, [0183] I.N
N-((3(5)-methyl-1H-pyrazole-1-yl)methyl)formamide, [0184] I.O
N-((3(5),4-dimethyl pyrazole-1-yl)methyl)formamide, [0185] I.P
N-((4-chloro-3(5)-methyl-pyrazole-1-yl)methyl)formamide, [0186] I.Q
reaction adduct of dicyandiamide, urea and formaldehyde, or a
triazonyl-formaldehyde-dicyandiamide adduct [0187] I.R
2-cyano-14(4-oxo-1,3,5-triazinan-1-yl)methyl)guanidine, [0188] I.S
1-((2-cyanoguanidino)methyl)urea, [0189] I.T
2-cyano-1-((2-cyanoguanidino)methyl)guanidine, [0190] I.U
2-chloro-6-(trichloromethyl)-pyridine (nitrapyrin or N-serve),
[0191] I.V dicyandiamide (DCD, DIDIN), [0192] I.W 3,4-dimethyl
pyrazole phosphate, and/or 4,5-dimethyl pyrazole phosphate (DMPP,
ENTEC), and/or an isomer thereof, and/or a derivative thereof,
[0193] I.X 3,4-dimethylpyrazole, and/or 4,5-dimethylpyrazole (DMP),
and/or an isomer thereof, and/or a derivative thereof, and/or a
salt thereof, and/or an acid addition salt thereof, [0194] I.Y
ammoniumthiosulfate (ATU), [0195] I.Z neem, [0196] I.AA linoleic
acid, [0197] I.AB alpha-linolenic acid, [0198] I.AC methyl
p-coumarate, [0199] I.AD methyl ferulate, [0200] I.AE methyl
3-(4-hydroxyphenyl) propionate (MHPP), [0201] I.AF brachialacton,
[0202] I.AG p-benzoquinone sorgoleone, [0203] I.AH
4-amino-1,2,4-triazole hydrochloride (ATC), [0204] I.AI
1-amido-2-thiourea (ASU), [0205] I.AJ
2-amino-4-chloro-6-methylpyrimidine (AM), [0206] I.AK
2-mercapto-benzothiazole (MBT), [0207] I.AL
5-ethoxy-3-trichloromethyl-1,2,4-thiodiazole (terrazole,
etridiazole), [0208] I.AM 2-sulfanilamidothiazole (ST), [0209] I.AN
3-methylpyrazol (3-MP), [0210] I.AO 1,2,4-triazol thiourea (TU),
[0211] I.AP cyan amide, [0212] I.AQ melamine, [0213] I.AR zeolite
powder, [0214] I.AS catechol, [0215] I.AT benzoquinone, [0216] I.AU
sodium tetra borate, [0217] I.AV allylthiourea, [0218] I.AW
chlorate salts, or [0219] I.AX zinc sulfate.
[0220] In one aspect of the invention, compound I is selected from
the group of compounds consisting of I.A, I.B, I.C, I.D, I.E, I.L,
I.M, I.N, I.O, I.P, I.Q, I.R, I.S., I.T, I.U, I.V, I.W, I.X, I.Y,
I.Z, I.AA, I.AB, I.AC, I.AD, I.AE, I.AF, I.AG, I.AH, I.AI, I.AJ,
I.AK, I.AL, I.AM, I.AN, I.AO, I.AP, I.AQ, I.AR, I.AS, I.AT, I.AU,
I.AV, I.AW, or I.AX, more preferably selected from the group of
compounds consisting of I.A, I.B, I.C, I.D, I.E, I.L, I.M, I.N,
I.O, I.P, I.Q, I.R, I.S., I.T, I.U, I.V, I.W, I.X, I.Y, I.AX, most
preferably selected from the group of compounds consisting of I.A,
I.B, I.C, I.D, I.E, I.L, I.M, I.N, I.O, I.P, I.Q, I.R, I.S.
[0221] With respect to their intended use in the methods of the
present invention, the following binary mixtures (A) listed in
tables 1 to 49 comprising one compound (I) and one compound (II)
are a preferred embodiment of the present invention.
TABLE-US-00001 TABLE 1 A I II A1 (I.A) Ampelomyces quisqualis A2
(I.A) Aspergillus flavus A3 (I.A) Aureobasidium pullulans A4 (I.A)
Bacillus altitudinis A5 (I.A) Bacillus amyloliquefaciens A6 (I.A)
Bacillus licheniformis A7 (I.A) Bacillus megaterium A8 (I.A)
Bacillus mojavensis A9 (I.A) Bacillus mycoides A10 (I.A) Bacillus
pumilus A11 (I.A) Bacillus simplex A12 (I.A) Bacillus solisalsi A13
(I.A) Bacillus subtitis A14 (I.A) Bacillus subtitis var.
amyloliquefaciens A15 (I.A) Candida oleophila A16 (I.A) Candida
saitoana A17 (I.A) Clavibacter michiganensis A18 (I.A) Coniothyrium
minitans A19 (I.A) Cryphonectria parasitica A20 (I.A) Cryptococcus
albidus A21 (I.A) Dilophosphora alopecuri A22 (I.A) Fusarium
oxysporum A23 (I.A) Clonostachys rosea f. catenulata A24 (I.A)
Gliocladium roseum A25 (I.A) Lysobacter antibioticus A26 (I.A)
Lysobacter enzymogenes A27 (I.A) Metschnikowia fructicola A28 (I.A)
Microdochium dimerum A29 (I.A) Microsphaeropsis ochracea A30 (I.A)
Muscodor albus A31 (I.A) Paenibacillus alvei A32 (I.A)
Paenibacillus epiphyticus A33 (I.A) Paenibacillus polymyxa A34
(I.A) Paenibacillus agglomerans A35 (I.A) Pantoea vagans A36 (I.A)
Penicillium bilaiae A37 (I.A) Phlebiopsis gigantea A38 (I.A)
Pseudomonas chlororaphis A39 (I.A) Pseudomonas fluorescens A40
(I.A) Pseudomonas putida A41 (I.A) Pseudozyma flocculosa A42 (I.A)
Pichia anomala A43 (I.A) Pythium oligandrum A44 (I.A) Sphaerodes
mycoparasitica A45 (I.A) Streptomyces griseoviridis A46 (I.A)
Streptomyces lydicus A47 (I.A) Streptomyces violaceusniger A48
(I.A) Talaromyces flavus A49 (I.A) Trichoderma asperellum A50 (I.A)
Trichoderma asperelloides A51 (I.A) Trichoderma atroviride A52
(I.A) Trichoderma fertile A53 (I.A) Trichoderma gamsii A54 (I.A)
Trichoderma harmatum A55 (I.A) Trichoderma harzianum A56 (I.A)
Trichoderma polysporum A57 (I.A) Trichoderma stromaticum A58 (I.A)
Trichoderma virens (=Gliocladium virens) A59 (I.A) Trichoderma
viride A60 (I.A) Typhula phacorrhiza A61 (I.A) Ulocladium
oudemansii A62 (I.A) Verticillium dahlia A63 (I.A) zucchini yellow
mosaic virus (avirulent strain) A64 (I.A) chitosan (hydrolysate)
A65 (I.A) fusaricidins A66 (I.A) paeniserines A67 (I.A)
paeniprolixines A68 (I.A) harpin protein A69 (I.A) laminarin A70
(I.A) Menhaden fish oil A71 (I.A) natamycin A72 (I.A) Plum pox
virus coat protein A73 (I.A) potassium or sodium bicarbonate A74
(I.A) Reynoutria sachalinensis extract A75 (I.A) salicylic acid A76
(I.A) tea tree oil (Melaleuca alternifolia extract) A77 (I.A)
Agrobacterium radiobacter A78 (I.A) Bacillus cereus A79 (I.A)
Bacillus firmus A80 (I.A) Bacillus subtilis A81 (I.A) Bacillus
licheniformis A82 (I.A) Bacillus thuringiensis A83 (I.A) Bacillus
thuringiensis ssp. aizawai A84 (I.A) Bacillus thuringiensis ssp.
israelensis A85 (I.A) Bacillus thuringiensis ssp. galleriae A86
(I.A) Bacillus thuringiensis ssp. kurstaki A87 (I.A) Bacillus
thuringiensis ssp. tenebrionis A88 (I.A) Beauveria bassiana A89
(I.A) Beauveria brongniartii A90 (I.A) Burkholderia rinojensis A91
(I.A) Chromobacterium subtsugae A92 (I.A) Cydia pomonella
granulovirus (CpGV) A93 (I.A) Cryptophlebia leucotreta granulovirus
(CrleGV) A94 (I.A) Flavobacterium spp. A95 (I.A) Helicoverpa
armigera nucleopolyhedrovirus (HearNPV) A96 (I.A) Heterorhabditis
bacteriophora A97 (I.A) Isaria fumosorosea A98 (I.A) Lecanicillium
longisporum A99 (I.A) Lecanicillium muscarium A100 (I.A)
Metarhizium anisopliae A101 (I.A) Metarhizium anisopliae var.
anisopliae A102 (I.A) Metarhizium anisopliae var. acridum A103
(I.A) Nomuraea rileyi A104 (I.A) Paecilomyces lilacinus A105 (I.A)
Paenibacillus popilliae A106 (I.A) Pasteuria nishizawae A107 (I.A)
Pasteuria penetrans A108 (I.A) Pasteuria ramosa A109 (I.A)
Pasteuria thornea A110 (I.A) Pasteuria usgae A111 (I.A) Pseudomonas
fluorescens A112 (I.A) Spodoptera littoralis nucleopolyhedrovirus
(SpliNPV) A113 (I.A) Steinernema carpocapsae A114 (I.A) Steinernema
feltiae A115 (I.A) Steinernema kraussei A116 (I.A) Steinernema
riobrave A117 (I.A) Streptomyces galbus A118 (I.A) Streptomyces
microflavus A119 (I.A) L-carvone A120 (I.A) citral A121 (I.A)
(E,Z)-7,9-dodecadien-1-yl acetate A122 (I.A) ethyl formate A123
(I.A) (E,Z)-2,4-ethyl decadienoate (pear ester) A124 (I.A)
(Z,Z,E)-7,11,13-hexadecatrienal A125 (I.A) heptyl butyrate A126
(I.A) isopropyl myristate A127 (I.A) lavanulyl senecioate A128
(I.A) cis-jasmone A129 (I.A) 2-methyl 1-butanol A130 (I.A) methyl
eugenol A131 (I.A) methyl jasmonate A132 (I.A)
(E,Z)-2,13-octadecadien-1-ol A133 (I.A)
(E,Z)-2,13-octadecadien-1-ol acetate A134 (I.A)
(E,Z)-3,13-octadecadien-1-ol A135 (I.A) R-1-octen-3-ol A136 (I.A)
pentatermanone A137 (I.A) potassium silicate A138 (I.A) sorbitol
actanoate A139 (I.A) (E,Z,Z)-3,8,11-tetradecatrienyl acetate A140
(I.A) (Z,E)-9,12-tetradecadien-1-yl acetate A141 (I.A)
Z-7-tetradecen-2-one A142 (I.A) Z-9-tetradecen-1-yl acetate A143
(I.A) Z-11-tetradecenal A144 (I.A) Z-11-tetradecen-1-ol A145 (I.A)
Acacia negra extract A146 (I.A) extract of grapefruit seeds and
pulp A147 (I.A) Chenopodium ambrosioides extract A148 (I.A) Catnip
oil A149 (I.A) Neem oil A150 (I.A) Quillay extract A151 (I.A)
Tagetes oil A152 (I.A) Azospirilium amazonense A153 (I.A)
Azospirillum brasilense A154 (I.A) Azospirilium lipoferum A155
(I.A) Azospirillum irakense A156 (I.A) Azospirilium halopraeferens
A157 (I.A) Bradyrhizobium elkanii A158 (I.A) Bradyrhizobium
japonicum A159 (I.A) Bradyrhizobium liaoningense A160 (I.A)
Bradyrhizobium lupini A161 (I.A) Bradyrhizobium arachis A162 (I.A)
Delftia acidovorans A163 (I.A) Glomus intraradices A164 (I.A)
Mesorhizobium spp. A165 (I.A) Rhizobium leguminosarum bv. phaseoli
A166 (I.A) Rhizobium leguminosarum bv. trifolii A167 (I.A)
Rhizobium leguminosarum bv. viciae A168 (I.A) Rhizobium tropici
A169 (I.A) Sinorhizobium meliloti A170 (I.A) Sinorhizobium medicae
A171 (I.A) abscisic acid A172 (I.A) aluminium silicate (kaolin)
A173 (I.A) 3-decen-2-one A174 (I.A) formononectin A175 (I.A)
genistein A176 (I.A) hesperetin A177 (I.A) homobrassinolide A178
(I.A) humates A179 (I.A) lysophosphatidyl ethanlamine A180 (I.A)
naringenin A181 (I.A) polymeric polyhydroxy acid A182 (I.A)
salicylic acid A183 (I.A) Ascophyllum nodosum (Norwegian kelp,
Brown kelp) extract and Ecklonia maxima (kelp) extract A184 (I.A)
zeolite (aluminosilicate) A185 (I.A) Paecilomyces lilacinus A186
(I.A) Phasmarhabditis hermaphrodita A187 (I.A) Mesorhizobium ciceri
A188 (I.A) Grape seed extract A = Mixture; I = compound I; II =
compound II
[0222] Table 2: The binary mixtures A189 to A376 correspond to the
mixtures A1 to A188, wherein compound I.A is replaced by compound
I.B.
[0223] Table 3: The binary mixtures A 377 to A 564 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.C.
[0224] Table 4: The binary mixtures A565 to A752 correspond to the
mixtures A1 to A188, wherein compound I.A is replaced by compound
I.D.
[0225] Table 5: The binary mixtures A753 to A940 correspond to the
mixtures A1 to A188, wherein compound I.A is replaced by compound
I.E.
[0226] Table 6: The binary mixtures A941 to A1128 correspond to the
mixtures A1 to A188, compound I.A is replaced by compound I.F.
[0227] Table 7: The binary mixtures A1129 to A1316 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.G.
[0228] Table 8: The binary mixtures A1317 to A1504 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.H.
[0229] Table 9: The binary mixtures A1505 to A1692 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.J.
[0230] Table 10: The binary mixtures A1693 to A1880 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.K.
[0231] Table 11: The binary mixtures A1881 to A2068 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.L.
[0232] Table 12: The binary mixtures A2069 to A2256 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.M.
[0233] Table 13: The binary mixtures A2257 to A2444 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.N.
[0234] Table 14: The binary mixtures A2445 to A2632 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.O.
[0235] Table 15: The binary mixtures A2633 to A2820 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.P.
[0236] Table 16: The binary mixtures A2821 to A3008 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.Q.
[0237] Table 17: The binary mixtures A3009 to A3196 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.R.
[0238] Table 18: The binary mixtures A3197 to A3384 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.S.
[0239] Table 19: The binary mixtures A3385 to A3572 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.T.
[0240] Table 20: The binary mixtures A3573 to A3760 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.U.
[0241] Table 21: The binary mixtures A3761 to A3948 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.V.
[0242] Table 22: The binary mixtures A3949 to A4136 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.W.
[0243] Table 23: The binary mixtures A4137 to A4324 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.X.
[0244] Table 24: The binary mixtures A4325 to A4512 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.Y.
[0245] Table 25: The binary mixtures A4513 to A4700 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.Z.
[0246] Table 26: The binary mixtures A4701 to A4888 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AA.
[0247] Table 27: The binary mixtures A4889 to A5076 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AB.
[0248] Table 28: The binary mixtures A5077 to A5264 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AC.
[0249] Table 29: The binary mixtures A5265 to A5452 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AD.
[0250] Table 30: The binary mixtures A5453 to A5640 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AE.
[0251] Table 31: The binary mixtures A5641 to A5828 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AF.
[0252] Table 32: The binary mixtures A5829 to A6016 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AG.
[0253] Table 33: The binary mixtures A6017 to A6204 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AH.
[0254] Table 34: The binary mixtures A6205 to A6392 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AI.
[0255] Table 35: The binary mixtures A6393 to A6580 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AJ.
[0256] Table 36: The binary mixtures A6581 to A6768 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AK.
[0257] Table 37: The binary mixtures A6769 to A6956 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AL.
[0258] Table 38: The binary mixtures A6957 to A7144 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AM.
[0259] Table 39: The binary mixtures A7145 to A7332 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AN.
[0260] Table 40: The binary mixtures A7333 to A7520 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AO.
[0261] Table 41: The binary mixtures A7521 to A7708 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AP.
[0262] Table 42: The binary mixtures A7709 to A7896 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AQ.
[0263] Table 43: The binary mixtures A7897 to A8084 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AR.
[0264] Table 44: The binary mixtures A8085 to A8272 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AS.
[0265] Table 45: The binary mixtures A8273 to A8460 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AT.
[0266] Table 46: The binary mixtures A8461 to A8648 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AU.
[0267] Table 47: The binary mixtures A8649 to A8836 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AV.
[0268] Table 48: The binary mixtures A8837 to A9024 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AW.
[0269] Table 49: The binary mixtures A9025 to A9212 correspond to
the mixtures A1 to A188, wherein compound I.A is replaced by
compound I.AX.
[0270] Within the mixtures of tables 1 to 49 the mixtures
comprising Ampelomyces quisqualis, Aspergillus flavus, Azospirillum
brasilense, Bacillus subtilis, Bacillus subtilis var.
amyloliquefaciens, Bacillus amyloliquefaciens, Bacillus pumilus,
Bacillus simplex, Beauveria bassiana, Bradyrhizobium lupini,
Bradyrhizobium arachis, Burkholderia rinojensis, Candida oleophila,
Candida saitoana, Chenopodium ambrosioides extract, chitosan
(hydrolysate), Chromobacterium subtsugae, Clonostachys rosea f.
catenulata, Coniothyrium minitans, Cryptococcus albidus, a
fusaricidin, a paeniserine, a paeniprolixine, Fusarium oxysporum,
Heterorhabditis bacteriophora, Mesorhizobium ciceri, Metschnikowia
fructicola, Microdochium dimerum, Penicillium bilaiae,
Phasmarhabditis hermaphrodita, Phlebiopsis gigantea, Pseudozyma
flocculosa, Pseudomonas chlororaphis, Pythium oligandrum,
Reynoutria sachalinensis extract, Rhizobium leguminosarum,
Rhizobium tropici, Sinorhizobium meliloti, Sinorhizobium medicae,
Steinernema carpocapsae, Steinernema kraussei, Steinernema feltiae,
Steinernema riobrave, Streptomyces lydicus, Talaromyces flavus,
Trichoderma asperellum, Trichoderma asperelloides, Trichoderma
atroviride, Trichoderma harzianum, Trichoderma polysporum,
Trichoderma vixens, Trichoderma viride, Trichoderma stromaticum,
Ulocladium oudemansii, zeolite (aluminosilicate), grape seed
extract, Bacillus firmus, Harpin protein, Neem oil, cis-jasmone,
methyl jasmonate, Bradyrhizobium japonicum, Bradyrhizobium elkanii;
Paecilomyces lilacinus, Pasteuria nishizawae, Metarhizium
anisopliae, Paenibacillus alvei, Paenibacillus polymyxa or
Paenibacillus epiphyticus are especially preferred mixtures
according to the invention.
[0271] In one embodiment, the mixture according to the invention
comprises at least one compound II (biopesticide) selected from the
group consisting of Bacillus amyloliquefaciens, Bacillus firmus,
Bacillus pumilus, Bacillus subtilis, Bacillus licheniformis,
Paenibacillus polymyxa, Paenibacillus epiphyticus, Pasteuria
nishizawae, Penicillium bilaiae fusaricidins and cis-jasmone.
[0272] In one embodiment, the mixture according to the invention
comprises a strain of Bacillus amyloliquefaciens as compound
II.
[0273] In one embodiment, the mixture according to the invention
comprises a strain of Bacillus firmus as compound II.
[0274] In one embodiment, the mixture according to the invention
comprises a strain of Bacillus pumilus as compound II.
[0275] In one embodiment, the mixture according to the invention
comprises a strain of Bacillus subtilis as compound II.
[0276] In one embodiment, the mixture according to the invention
comprises a strain of Bacillus licheniformis as compound II.
[0277] In one embodiment, the mixture according to the invention
comprises a strain of Paenibacillus polymyxa as compound II.
[0278] In one embodiment, the mixture according to the invention
comprises a strain of Paenibacillus epiphyticus as compound II.
[0279] In one embodiment, the mixture according to the invention
comprises a strain of Pasteuria nishizawae as compound II.
[0280] In one embodiment, the mixture according to the invention
comprises a strain of Penicillium bilaiae as compound II.
[0281] In one embodiment, the mixture according to the invention
comprises a fusaricidin as compound II.
[0282] In one embodiment, the mixture according to the invention
comprises cis-jasmone as compound II.
[0283] In one embodiment, the mixture according to the invention
comprises at least one compound II (biopesticide) selected from the
groups L1) to L6):
[0284] L1) Microbial pesticides with fungicidal, bactericidal,
viricidal and/or plant defense activator activity: Ampelomyces
quisqualis M-10 (L.1.1), Aspergillus flavus NRRL 21882 (L.1.2),
Aureobasidium pullulans DSM 14940 (L1.3), Aureobasidium pullulans
DSM 14941 (L.1.4), Bacillus altitudinis 41 KF2b (L.1.5), Bacillus
amyloliquefaciens AP-136 (L.1.6), Bacillus amyloliquefaciens AP-188
(L.1.7), Bacillus amyloliquefaciens AP-218 (L.1.8), Bacillus
amyloliquefaciens AP-219 (L.1.9), Bacillus amyloliquefaciens AP-295
(L.1.10), Bacillus amyloliquefaciensIN937a (L.1.11), Bacillus
amyloliquefaciens IT-45 (L.1.12), Bacillus amyloliquefaciens ssp.
plantarum D747 (L.1.13), Bacillus amyloliquefaciens ssp. plantarum
FZB24 (L.1.14), Bacillus amyloliquefaciens ssp. plantarum FZB42
(L.1.15), Bacillus amyloliquefaciens ssp. plantarum GB03 (=Bacillus
subtilis GB03) (L.1.16), Bacillus amyloliquefaciens ssp. plantarum
MBI600 (NRRL B-50595) (L.1.17), Bacillus amyloliquefaciens ssp.
plantarum QST-713 (L.1.18), Bacillus amyloliquefaciens ssp.
plantarum TJ 1000 (L.1.19), Bacillus mojavensis AP-209 (L.1.20),
Bacillus mycoides AQ726 (L.1.21), Bacillus mycoides strain J
(L.1.22), Bacillus pumilus INR-7 (L.1.23), B. pumilus KFP9F
(L.1.24), Bacillus pumilus QST 2808 (L.1.25), Bacillus pumilus GHA
180 (L.1.26), Bacillus solisalsi AP-217 (L.1.28), Bacillus subtilis
CX-9060 (L.1.29), Bacillus subtilis FB17 (L.1.30), Bacillus
subtilis GB07 (L.1.31), Candida oleophila I-82 (L.1.32), Candida
oleophila O (L.1.33), Candida saitoana (L.1.34), Clavibacter
michiganensis (bacteriophages) (L.1.35), Coniothyrium minitans
CON/M/91-08 (L.1.36), Cryphonectria parasitica (L.1.37),
Cryptococcus albidus (L.1.38), Dilophosphora alopecuri (L.1.39),
Fusarium oxysporum (L.1.40), Clonostachys rosea f. catenulata J1446
(L.1.41), Gliocladium roseum 321U (L.1.42), Metschnikowia
fructicola NRRL Y-30752 (L.1.43), Microdochium dimerum (L.1.44),
Microsphaeropsis ochracea P130A (L.1.45), Muscodor albus QST 20799
(L.1.46), Muscodor albus SA-13 (L.1.47), Paenibacillus alvei NAS6G6
(L.1.48), Paenibacillus polymyxa PKB1 (L.1.49), Pantoea agglomerans
E325 (L.1.90), Pantoea vagans C9-1 (L.1.50), Penicillium bilaiae
ATCC 22348 (L.1.51), P. bilaiae ATCC 20851 (L.1.52), Penicillium
bilaiae ATCC 18309 (L.1.53), Phlebiopsis gigantea (L.1.54), Pichia
anomala WRL-76 (L.1.55), Pseudomonas sp. Proradix (L.1.56),
Pseudomonas chlororaphis MA 342 (L.1.57), P. fluorescens A506
(L.1.58), P. fluorescens CL 145A (L.1.91), P. fluorescens NCIB
12089 (L.1.92), P. fluorescens Pf-5 (L.1.93), P. fluorescens WCS
374 (L.1.94), P. fluorescens ATCC 13525 (L.1.95), P. fluorescens
CHAO (L.1.96), P. putida ATCC 202153 (L.1.97), Pseudozyma
flocculosa PF-A22 UL (L.1.59), Pythium oligandrum DV 74 (L.1.60),
Sphaerodes mycoparasitica SMCD2220 (L.1.61), Streptomyces
griseoviridis K61 (L.1.62), Streptomyces lydicus WYEC 108 (L.1.63),
Streptomyces violaceusniger XL-2 (L.1.64), Streptomyces
violaceusniger YCED-9 (L.1.65), Talaromyces flavus V117b (L.1.66),
Trichoderma asperellum T34 (L.1.67), Trichoderma asperellum SKT-1
(L.1.68), Trichoderma asperellum ICC 012 (L.1.69), Trichoderma
atroviride LC52 (L.1.70), Trichoderma atroviride CNCM I-1237
(L.1.71), Trichoderma asperelloides JM41R (=Trichoderma fertile)
(L.1.72), Trichoderma gamsii ICC 080 (L.1.73), Trichoderma harmatum
TH 382 (L.1.74), Trichoderma harzianum T-35 (L.1.75), Trichoderma
harzianum T-22 (L.1.76), Trichoderma harzianum T-39 (L.1.77);
mixture of Trichoderma harzianum ICC012 and Trichoderma viride
ICC080 (L.1.78); Trichoderma polysporum (L.1.79); Trichoderma
stromaticum (L.1.80), Trichoderma virens GI-3 (L.1.81), Trichoderma
virens G-41 (L.1.82), Trichoderma virens GL-21 (=Gliocladium virens
GL-21) (L.1.83), Trichoderma virens G-41 (L.1.84), Trichoderma
viride TV1 (L.1.85), Typhula phacorrhiza 94671 (L.1.86), Ulocladium
oudemansii HRU3 (L.1.87), Verticillium dahlia (L.1.88), zucchini
yellow mosaic virus (avirulent strain) (L.1.89), Bacillus
licheniformis SB3086 (L.1.90), Paenibacillus polymyxa Lu16774
(L.1.91), Paenibacillus polymyxa Lu17007 (L.1.92), Paenibacillus
epiphyticus Lu17015 (L.1.93), Paenibacillus sp. NRRL B-50972
(L.1.94), Paenibacillus sp. strain NRRL B-67129 (L.1.95), Bacillus
pumilus strain GB34 (L.1.96);
L2) Biochemical pesticides with fungicidal, bactericidal, viricidal
and/or plant defense activator activity: chitosan (hydrolysate)
(L.2.1), harpin protein (L.2.2), laminarin (L.2.3), Menhaden fish
oil (L.2.4), natamycin (L.2.5), Plum pox virus coat protein
(L.2.6), potassium bicarbonate (L.2.7), Reynoutria sachalinensis
extract (L.2.8), salicylic acid (L.2.9), potassium or sodium
bicarbonate (L.2.10), tea tree oil (Melaleuca alternifolia extract)
(L.2.11), fusaricidin A (L.2.12), fusaricidin B (L.2.13),
fusaricidin C (L.2.14), fusaricidin D (L.2.15), fusaricidin LI F03
(L.2.16), fusaricidin LI F04 (L.2.17), fusaricidin LI-F05 (L.2.18),
fusaricidin LI-F06 (L.2.18), fusaricidin LI-F07 (L.2.19),
fusaricidin LI-F08 (L.2.20), fusaricidin 1A (L.2.21), fusaricidin
1B (L.2.22), paeniserine A (L.2.23), paeniserine B (L.2.24)
paeniserine C (L.2.25), paeniserine D (L.2.26) paeniprolixine A
(L.2.27), paeniprolixine B (L.2.28), paeniprolixine C (L.2.29),
paeniprolixine D (L.2.30), paeniprolixine E (L.2.31),
paeniprolixine F (L.2.32), paeniprolixine G (L.2.33); L3) Microbial
pesticides with insecticidal, acaricidal, molluscidal and/or
nematicidal activity: Agrobacterium radiobacter K1026 (L.3.1), A.
radiobacterK84 (L.3.2), Bacillus firmus I-1582 (L.3.3); B.
thuringiensis ssp. aizawai strains: ABTS-1857 (L.3.4), SAN 4011
(L.3.5), ABG-6305 (L.3.6) and ABG-6346 (L.3.7); B. t. ssp.
israelensis AM65-52 (L.3.8), B. t. ssp. Israelensis SUM-6218
(L.3.9), B. t. ssp. galleriae SDS-502 (L.3.10), B. t. ssp. kurstaki
EG2348 (L.3.11), B. t. ssp. kurstaki SB4 (L.3.12), B. t. ssp.
kurstaki ABTS-351 (HD-1) (L.3.13), Beauveria bassiana ATCC 74040
(L.3.14), Beauveria bassiana GHA (L.3.15), Beauveria bassiana H123
(L.3.16), Beauveria bassiana DSM 12256 (L.3.17), Beauveria bassiana
PPRI 5339 (L.3.18), B. brongniartii (L.3.19), Burkholderia
rinojensis A396 (L.3.20), Chromobacterium subtsugae PRAA4-1.sup.T
(L.3.21), Cydia pomonella granulosis virus V22 (L.3.22), Cydia
pomonella granulosis virus V1 (L.3.23), Cryptophlebia leucotreta
granulovirus (CrleGV) (L.3.57), Flavobacterium sp. H492 (L.3.60),
Helicoverpa armigera nucleopolyhedrovirus (HearNPV) (L.3.58),
Isaria fumosorosea Apopka-97 (L.3.24), Lecanicillium longisporum
KV42 (L.3.25), Lecanicillium longisporum KV71 (L.3.26),
Lecanicillium muscarium KV01 (L.3.27), Metarhizium anisopliae
FI-985 (L.3.28), Metarhizium anisopliae FI-1045 (L.3.29),
Metarhizium anisopliae F52 (L.3.30), Metarhizium anisopliae ICIPE
69 (L.3.31), Metarhizium anisopliae var. acridum IMI 330189
(L.3.32); Nomuraea rileyi strains: SA86101 (L.3.33), GU87401
(L.3.34), SR 86151 (L.3.35), CG128 (L.3.36) and VA9101 (L.3.37);
Paecilomyces fumosoroseus FE 9901 (L.3.38), Paecilomyces lilacinus
251 (L.3.39), Paecilomyces DSM 15169 (L.3.40), Paecilomyces
lilacinus BCP2 (L.3.41), Paenibacillus popilliae Dutky-1940 (NRRL
B-2309=ATCC 14706) (L.3.42), Paenibacillus popilliae Dutky 1
(L.3.43), Paenibacillus popilliae KLN 3 (L.3.56), Pasteuria sp. Ph3
(L.3.44), Pasteuria sp. ATCC PTA-9643 (L.3.45), Pasteuria sp. ATCC
SD-5832 (L.3.46), P. nishizawae Pn1 (L.3.46), P. penetrans
(L.3.47), P. ramosa (L.3.48), P. sp. Pr-3 (L.3.49), P. thornea
(L.3.50), P. usgae (L.3.51), Pseudomonas fluorescens CL 145A
(L.3.52), Spodoptera littoralis nucleopolyhedrovirus (SpliNPV)
(L.3.59), Steinernema carpocapsae (L.3.53), Steinernema feltiae
UK76 (L.3.54), Steinernema kraussei L137 (L.3.55), Beauveria
bassiana 147 (L.3.56), Beauveria bassiana NPP111B005 (L.3.57);
Bacillus subtilis linhagem QST 713 (L.3.58), Bacillus licheniformis
RT1184 (L.3.59), Paecilomyces lilacinus (L.3.60), Steinernema
riobrave 355 (L.3.61), Phasmarhabditis hermaphrodita DMG 0001
(L.3.62), Heterorhabditis bacteriophora GPS11 (L.3.63); L4)
Biochemical pesticides with insecticidal, acaricidal, molluscidal,
pheromone and/or nematicidal activity: L-carvone (L.4.1), citral
(L.4.2), (E,Z)-7,9-dodecadien-1-yl acetate (L.4.3), ethyl formate
(L.4.4), (E,Z)-2,4-ethyl decadienoate (pear ester) (L.4.5),
(Z,Z,E)-7,11,13-hexadecatrienal (L.4.6), heptyl butyrate (L.4.7),
isopropyl myristate (L.4.8), cis-jasmone (L.4.9), lavanulyl
senecioate (L.4.10), 2-methyl 1-butanol (L.4.11), methyl eugenol
(L.4.12), methyl jasmonate (L.4.13), (E,Z)-2,13-octadecadien-1-ol
(L.4.14), (E,Z)-2,13-octadecadien-1-ol acetate (L.4.15),
(E,Z)-3,13-octadecadien-1-ol (L.4.16), R-1-octen-3-ol (L.4.17),
pentatermanone (L.4.18), potassium silicate (L.4.19), sorbitol
actanoate (L.4.20), (E,Z,Z)-3,8,11-tetradecatrienyl acetate
(L.4.21), (Z,E)-9,12-tetradecadien-1-yl acetate (L.4.22),
Z-7-tetradecen-2-one (L.4.23), Z-9-tetradecen-1-yl acetate
(L.4.24), Z-11-tetradecenal (L.4.25), Z-11-tetradecen-1-ol
(L.4.26), Acacia negra extract (L.4.27), extract of grapefruit
seeds and pulp (L.4.28), Chenopodium ambrosioides extract (L.4.29),
Catnip oil (L.4.30), Neem oil (L.4.31), Quillay extract (L.4.32),
Tagetes oil (L.4.33); L5) Microbial pesticides with plant stress
reducing, plant growth regulator, plant growth promoting and/or
yield enhancing activity: Azospirillum amazonense BR 11140 (SpY2)
(L.5.1), A. brasilense Ab-V5 (L.5.74), A. brasilense Ab-V6
(L.5.75), A. brasilense AZ39 (L.5.2), A. brasilense XOH (L.5.3), A.
brasilense Sp245 (BR 11005) (L.5.4), A. brasilense BR 11002
(L.5.5), A. lipoferum BR 11646 (Sp31) (L.5.6), A. irakense (L.5.7),
A. halopraeferens (L.5.8), Bradyrhizobium sp. PNL01 (L.5.9),
Bradyrhizobium sp. (Arachis) CB1015 (L.5.10), Bradyrhizobiumsp.
(Arachis) USDA 3446 (L.5.11), Bradyrhizobiumsp. (Arachis) SEMIA
6144 (L.5.12), Bradyrhizobium sp. (Arachis) SEMIA 6462 (L.5.13),
Bradyrhizobium sp. (Arachis) SEMIA 6464 (L.5.14), Bradyrhizobium
sp. (Vigna) (L.5.15), Bradyrhizobium elkanii SEMIA 587 (L.5.16),
Bradyrhizobium elkanii SEMIA 5019 (L.5.17), Bradyrhizobium elkanii
U-1301 (L.5.18), Bradyrhizobium elkanii U-1302 (L.5.19),
Bradyrhizobium USDA 74 (L.5.20), Bradyrhizobium elkanii USDA 76
(L.5.21), Bradyrhizobium elkanii USDA 94 (L.5.22), B. elkanii USDA
3254 (L.5.23), Bradyrhizobium japonicum 532c (L.5.24),
Bradyrhizobium japonicum CPAC 15 (L.5.25), Bradyrhizobium japonicum
E-109 (L.5.26), Bradyrhizobium japonicum G49 (L.5.27),
Bradyrhizobium japonicum TA-11 (L.5.28), Bradyrhizobium japonicum
USDA 3 (L.5.29), Bradyrhizobium japonicum USDA 31 (L.5.30),
Bradyrhizobium japonicum USDA 76 (L.5.31), Bradyrhizobium japonicum
USDA 110 (L.5.32), Bradyrhizobium japonicum USDA 121 (L.5.33),
Bradyrhizobium japonicum USDA 123 (L.5.34), Bradyrhizobium
japonicum USDA 136 (L.5.35), Bradyrhizobium japonicum SEMIA 566
(L.5.36), Bradyrhizobium japonicum SEMIA 5079 (L.5.37),
Bradyrhizobium japonicum SEMIA 5080 (L.5.38), Bradyrhizobium
japonicum WB74 (L.5.39), Bradyrhizobium liaoningense (L.5.40),
Bradyrhizobium lupini LL13 (L.5.41), Bradyrhizobium lupini WU425
(L.5.42), Bradyrhizobium lupini WSM471 (L.5.43), Bradyrhizobium
lupini WSM4024 (L.5.44), Glomus intraradices RTI-801 (L.5.45),
Mesorhizobium sp. WSM1271 (L.5.46), Mesorhizobium sp. WSM1497
(L.5.47), Mesorhizobium ciceri CC1192 (L.5.48), Mesorhizobium
huakii (L.5.49), Mesorhizobium loti CC829 (L.5.50), Mesorhizobium
loti SU 343 (L.5.51), Rhizobium leguminosarum bv. phaseoli RG-B10
(L.5.52), R. I. bv. trifolii RP113-7 (L.5.53), R. I. bv. trifolii
095 (L.5.57), R. I. bv. trifolii TA1 (L.5.58), R. I. bv. trifolii
CC283b (L.5.59), R. I. bv. trifolii CC275e (L.5.60), R. I. bv.
trifolii CB782 (L.5.61), R. I. bv. trifolii CC1099 (L.5.62), R. I.
bv. trifolii WSM1325 (L.5.63), R. I. bv. viciae SU303 (L.5.64), R.
I. bv. viciae WSM1455 (L.5.65), R. I. bv. viciae P1NP3Cst (=1435)
(L.5.66), R. I. bv. viciae RG-P2 (L.5.67), R. tropici PRF81
(L.5.68), R. tropici SEMIA 4077 (L.5.69), R. tropici CC511(L.5.70),
Sinorhizobium meliloti RCR2011 (L.5.71), S. meliloti NRG185
(L.5.72), S. meliloti RR1128 (L.5.73), Bacillus licheniformis
RTI184 (L.5.74), Bacillus licheniformis CH200 (L.5.75), Bacillus
simplex ABU 288 (L.5.76), Bradyrhizobium lupini LL13 (L.5.77),
Mesorhizobium ciceri CC1653 (L.5.78), Sinorhizobium medicae WSM1115
(L.5.79), Bradyrhizobium japonicum CB1809 (L.5.80), Bradyrhizobium
japonicum 3407 (L.5.81), Rhizobium tropici SEMIA 4088 (L.5.82),
Bradyrhizobium NC92 (L.5.83), Bradyrhizobium CB1024 (L.5.84); L6)
Biochemical pesticides with plant stress reducing, plant growth
regulator and/or plant yield enhancing activity: abscisic acid
(L.6.1), aluminium silicate (kaolin) (L.6.2), 3-decen-2-one
(L.6.3), formononectin (L.6.4), genistein (L.6.5), hesperetin
(L.6.6), homobrassinolide (L.6.7), humates (L.6.8), methyl
jasmonate (L.6.9), cis-jasmone (L.6.10), lysophosphatidyl
ethanlamine (L.6.11), naringenin (L.6.12), polymeric polyhydroxy
acid (L.6.13), salicylic acid (L.6.14), Ascophyllum nodosum
(Norwegian kelp, Brown kelp) extract (L.6.15) and Ecklonia maxima
(kelp) extract (L.6.16), zeolite (aluminosilicate) (L.6.17), grape
seed extract (L.6.18).
[0285] In one embodiment, the mixture according to the invention
comprises a compound II selected from the group consisting of
Bacillus firmus CNCM I-1582 (L.3.3), Bacillus amyloliquefaciens
ssp. plantarum M B1600 (NRRL B-50595) (L.1.17), Bacillus subtilis
linhagem QST 713 (L.3.58), Bacillus licheniformis RTI184 (L.3.59),
Paenibacillus polymyxa Lu16774 (L.1.91), Paenibacillus polymyxa
Lu17007 (L.1.92), Paenibacillus epiphyticus Lu17015 (L.1.93),
Pasteuria nishizawae Pn1 (L.3.46), Penicillium ATCC 22348 (L.1.51),
Penicillium bilaiae ATCC 20851 (L.1.52) and Penicillium bilaiae
ATCC 18309 (L.1.53).
[0286] In one preferred embodiment, the mixture according to the
invention comprises Bradyrhizobium japonicum 532c (L.5.24) as
compound II.
[0287] In one preferred embodiment, the mixture according to the
invention comprises grape seed extract (L.6.18) as compound II.
[0288] In another preferred embodiment, the mixture according to
the invention comprises
a) DMPSA1 and/or DMPSA2, and/or a derivative thereof, and/or a salt
thereof, as compound I (nitrication inhibitor), b) Bradyrhizobium
japonicum as compound II.
[0289] In another preferred embodiment, the mixture according to
the invention comprises
a) DMPSA1 and/or DMPSA2, and/or a derivative thereof, and/or a salt
thereof, as compound I (nitrication inhibitor), b) Bradyrhizobium
japonicum 532c (L.5.24) as compound II.
[0290] In another preferred embodiment, the mixture according to
the invention comprises
a) DMPSA1 and/or DMPSA2, and/or a derivative thereof, and/or a salt
thereof, as compound I (nitrication inhibitor), b) grape seed
extract (L.6.18) as compound II.
[0291] In one preferred embodiment, the mixture according to the
invention comprises Bacillus firmus CNCM I-1582 (L.3.3) as compound
II.
[0292] In one preferred embodiment, the mixture according to the
invention comprises Bacillus amyloliquefaciens ssp. plantarum
MB1600 (NRRL B-50595) (L.1.17) as compound II.
[0293] In one preferred embodiment, the mixture according to the
invention comprises Bacillus subtilis linhagem QST 713 (L.3.58) as
compound II.
[0294] In one preferred embodiment, the mixture according to the
invention comprises Bacillus licheniformis RTI184 (L.3.59) as
compound II.
[0295] In one preferred embodiment, the mixture according to the
invention comprises Paenibacillus polymyxa Lu16774 (L.1.91) as
compound II.
[0296] In one preferred embodiment, the mixture according to the
invention comprises Paenibacillus polymyxa Lu17007 (L.1.92) as
compound II.
[0297] In one preferred embodiment, the mixture according to the
invention comprises Paenibacillus epiphyticus Lu17015 (L.1.93) as
compound II.
[0298] In one preferred embodiment, the mixture according to the
invention comprises Pasteuria nishizawae Pn1 (L.3.46) as compound
II.
[0299] In one preferred embodiment, the mixture according to the
invention comprises Penicillium bilaiae ATCC 22348 (L.1.51) as
compound II.
[0300] In one preferred embodiment, the mixture according to the
invention comprises Penicillium bilaiae ATCC 20851 (L.1.52) as
compound II.
[0301] In one preferred embodiment, the mixture according to the
invention comprises Penicillium bilaiae ATCC 18309 (L.1.53) as
compound II.
[0302] Preference is also given to mixtures comprising as compound
II a biopesticide from group L1), preferably selected from Bacillus
amyloliquefaciens herein even more preferably from strains AP-136,
AP-188, AP-218, AP-219, AP-295, IN937a, IT-45; B. amyloliquefaciens
ssp. plantarum (formerly called B. subtilis or B. subtilis spp.
amyloliquefaciens) herein even more preferably from strains M
B1600, D747, FZB254, FZB42, GB03, QST-713 and TJ1000; B. mojavensis
AP-209; B. pumilus herein even more preferably from strains GHA
180, INR-7, KFP9F and QST 2808; B. solisalsi herein more preferably
strain AP-217; B. subtilis herein even more preferably selected
from strains CX-9060, FB17 and GB07; Muscodor albus herein more
preferably strains QST 20799 and SA-13; Paenibacillus alvei herein
more preferably strain NAS6G6, Paenibacillus polymyxa herein more
preferably strain PKB1, Penicillium bilaiae herein more preferably
strains ATCC 22348, ATCC 20581 and ATCC 18309; Pseudomonas
fluorescens herein more preferably strain A506; Sphaerodes
mycoparasitica herein more preferably strain SMCD2220; Trichoderma
fertile herein more preferably strain JM41R; Trichoderma harzianum
herein more preferably strain T-22; Trichoderma virens herein more
preferably strains GI-3 and G-41.
[0303] Preference is also given to mixtures comprising as compound
II a biopesticide from group L1), even more preferably selected
from B. amyloliquefaciens AP-188, B. amyloliquefaciens ssp.
plantarum MBI600, B. amyloliquefaciens ssp. plantarum QST-713, B.
pumilus INR-7, B. pumilus QST 2808, B. subtilis FB17, Paenibacillus
alvei NAS6G6 and Trichoderma fertile JM41R.
[0304] According to one embodiment of the inventive mixtures, the
at least one compound II is Bacillus amyloliquefaciens ssp.
plantarum MBI 600. These mixtures are particularly suitable in
soybean.
[0305] According to another embodiment of the inventive mixtures,
the at least one compound II is B. pumilus INR-7. These mixtures
are particularly suitable in soybean and corn.
[0306] According to a further embodiment, the at least one compound
II is Bacillus subtilis, preferably B. subtilis strain FB 17.
[0307] According to one embodiment of the inventive mixtures, the
at least one compound II is selected from Bacillus
amyloliquefaciens AP-136, B. amyloliquefaciens AP-188, B.
amyloliquefaciens AP-218, B. amyloliquefaciens AP-219, B.
amyloliquefaciens AP-295, B. amyloliquefaciens spp. plantarum
FZB24, B. amyloliquefaciens ssp. plantarum FZB42, B.
amyloliquefaciens ssp. plantarum TJ1000, B. amyloliquefaciens ssp.
plantarum D747, B. amyloliquefaciens ssp. plantarum MBI600, B.
amyloliquefaciens spp. plantarum G B03, B. amyloliquefaciens spp.
plantarum QST-713, B. mojavensis AP-209, B. pumilus GB34, B.
pumilus INR-7, B. pumilus KFP9F, a pumilus QST 2808, B. pumilus GHA
180, B. solisalsi AP-217, B. subtilis CX-9060, B. subtilis FB17 and
B. subtilis GB07. These mixtures are particularly suitable in
soybean and corn, in particular for seed treatment.
[0308] According to a further embodiment, the at least one compound
11 is selected from Streptomyces spp., preferably from S.
griseoviridis, S. lydicus and S. violaceusniger, in particular from
strains S. griseoviridis K61, S. lydicus WYEC 108, S.
violaceusniger XL-2 and S. violaceusniger YCED-9.
[0309] According to one embodiment of the inventive mixtures, the
at least one compound II is selected from the following fungi
Coniothyrium minitans CON/M/91-08, Trichoderma fertile JM41R, T.
harzianum T-22, T. virens G1-3, T. virens GL-21, T. virens G-41.
These mixtures are particularly suitable for seed and/or soil
treatment.
[0310] The present invention also relates to mixtures wherein the
at least one compound II is selected from the following yeasts and
fungi: Ampelomyces quisqualis, in particular strain M-10;
Aureobasidium pullulans, in particular blastospores of strain
DSM14940 or blastospores of strain DSM 14941 or mixtures thereof;
Candida oleophila, in particular strains 1-182 and O; Coniothyrium
minitans, in particular strain CON/M/91-8; Dilophosphora alopecuri
which reduces annual ryegrass toxicity (ARGT), a disease of
livestock resulting from the ingestion of annual ryegrass
seed-heads that have been infected by the toxin producing bacterium
Rathayibacter toxicus, Clonostachys rosea f. catenulata, in
particular strain J1446; Metschnikovia fructicola, in particular
strain 277, Microsphaeropsis ochracea, in particular strain P130A
for control of apple scab; Muscodor albus, in particular strain QST
20799, Pichia anomala, in particular strain WRL-076, Pseudozyma
flocculosa, in particular strain PF-A22 UL; Pythium oligandrum, in
particular strain DV74.
[0311] According to a further embodiment, the at least one compound
II is selected from Pseudomonas spp., preferably selected from P.
chlororaphis herein more preferably strain MA 342 and Pseudomonas
sp. DSM 13134; P. fluorescens herein more preferably selected from
strains A506, WCS 374 and Pf-5; and P. putida herein more
preferably strain ATCC 202153.
[0312] The present invention also relates to mixtures wherein the
at least one compound II is selected from the fungal genus
Trichoderma, preferably from the strains T. asperellum T34, T.
asperellum SKT-1, T. asperellum ICC 012, T. asperellum TV1, T.
atroviride LC52, T. atroviride CNCM I-1237, T. fertile JM41R, T.
gamsii ICC 080, T. harmatum TH 382, T. harzianum T-22, T. harzianum
T-35, T. harzianum T-39, T. harzianum T-315; mixture of T.
harzianum ICC012 and T. gamsi ICC080; mixture of T. polysporum and
T. harzianum; T. stromaticum, T. virens GI-3, T. virens GL-21, T.
virens G-41 and; in particular T. fertile JM41R.
[0313] The present invention also relates to mixtures wherein the
at least one compound II is selected from the fungal species
Muscodor albus preferably from the strains SA-13 and QST 20799,
which are particularly suitable for soil and seed treatment against
soil-borne pathogens and/or nematodes.
[0314] Preference is also given to mixtures comprising as compound
II a biopesticide from group L2), preferably selected from chitosan
(hydrolysate), methyl-jasmonate, cis-jasmone, laminarin, Reynoutria
sachalinensis extract and tea tree oil; even more preferable from
methyl jasmonate, cis-jasmone and laminarin.
[0315] Preference is also given to mixtures comprising as compound
II a biopesticide from group L2), preferably selected from
fusaricidins, paeniserines and paeniprolixines.
[0316] Especially preferred are mixtures comprising as compound 11
at least one fusaricidin.
[0317] Preference is also given to mixtures comprising as compound
II a biopesticide from group L3), preferably selected from
Agrobacterium radiobacter herein preferably strain K1026, Bacillus
firmus herein preferably strain 1-1582, Bacillus thuringiensis ssp.
kurstaki herein preferably strain SB4, Beauveria bassiana herein
preferably selected from strains GHA, H123, DSM 12256 and PPRI
5339; Burkholderia sp. and herein preferably strain A396,
Metarhizium anisopliae var. acridum herein preferably strain
IM1330189, M. anisopliae herein preferably selected from strains
FI-985, FI-1045, F52 and ICIPE 69; Paecilomyces lilacinus herein
preferably selected from strains 251, DSM 15169 and BCP2,
Paenibacillus popilliae herein preferably selected from strains
Dutky-1940, KLN 3 and Dutky 1; Pasteuria nishazawa and herein
preferably strain Pn1.
[0318] Preference is also given to mixtures comprising as compound
II a biopesticide from group L3), even more preferably from
Bacillus thuringiensis ssp. kurstaki SB4, B. bassiana DSM 12256, B.
bassiana PPRI 5339, Metarhizium anisopliae var. acridum IMI 330189,
M. anisopliae FI-985, M. anisopliae FI-1045, Paecilomyces lilacinus
DSM 15169, P. lilacinus BCP2, P. lilacinus 251, Paenibacillus
Dutky-1940, P. popilliae KLN 3 and P. popilliae Dutky 1.
[0319] According to a further embodiment, the at least one compound
11 is Beauveria brongniartii.
[0320] According to a further embodiment, the at least one compound
11 is Metarhizium anisopliae or anisopliae var. acridium,
preferably selected from M. anisopliae F1-1045, M. anisopliae F52,
anisopliae var. acridum strains FI-985 and IMI 330189; in
particular strain IMI 330189. These mixtures are particularly
suitable for control of arthropod pests in soybean and corn.
[0321] According to a further embodiment, the at least one compound
II is Lecanicillium sp., preferably selected from Lecanicillium
longisporum KV42, L. longisporum KV71 and L. muscarium KV01.
[0322] According to a further embodiment, the at least one compound
11 is Paecilomyces fumosoroseus, preferably strain FE 9901
especially for white fly control.
[0323] According to a further embodiment, the at least one compound
II is selected from Nomuraea rileyi, preferably strains SA86101,
GU87401, SR86151, CG128 and VA9101; and P. lilacinus, preferably
strains 251, DSM 15169 or BCP2, in particular BCP2, which strains
especially control the growth of plant-pathogenic nematodes.
[0324] According to a further embodiment, the at least one compound
II is Bacillus firmus, preferably spores of strain CNCM I-1582,
preferably useful for seed treatment of soybean and corn against
nematodes and insects.
[0325] According to a further embodiment, the at least one compound
II is Bacillus cereus, preferably spores of CNCM I-1562, preferably
useful for seed treatment of soybean and corn against nematodes and
insects.
[0326] According to a further embodiment, the at least one compound
II is a mixture of spores of B. firmus and B. cereus, preferably
mixtures spores of above mentioned strains CNCM I-1582 and CNCM
I-1562, preferably useful for seed treatment of soybean and corn
against nematodes and insects.
[0327] According to a further embodiment, the at least one compound
II is selected from Bacillus t. ssp. kurstaki preferably from
strains EG 2348, SB4 and ABTS-351 (HD-1), in particular B. t. ssp.
kurstaki SB4. These strains are used for control of lepidopteran
larvae, but without noctuidae.
[0328] According to one embodiment of the inventive mixtures, the
at least one compound II is selected from Bacillus firmus CNCM
I-1582, Paecilomyces lilcinus 251, Pasteuria nishizawa Pn1 and
Burkholderia sp. A396 having nematicidal, acaricidal and/or
insecticidal activity. These mixtures are particularly suitable in
soybean and corn, in particular for seed treatment.
[0329] Preference is also given to mixtures comprising as compound
11 a biopesticide from group L4), preferably selected from methyl
jasmonate, Acacia negra extract, extract of grapefruit seeds and
pulp, Catnip oil, Neem oil, Quillay extract and Tagetes oil, in
particular methyl jasmonate or water-based Quillay extract.
[0330] Preference is also given to mixtures comprising as compound
11 a biopesticide from group L5), preferably selected from
Azospirillum amazonense, A. brasilense, A. lipoferum, A. irakense,
A. halopraeferens, Bradyrhizobium sp. (Arachis), Bradyrhizobium sp.
(Vigna), B. elkanii, B. japonicum; Paenibacillus alvei, Penicillium
bilaiae, Rhizobium leguminosarum bv. phaseoli, R. I. bv. trifolii,
R. I. bv. viciae, and Sinorhizobium meliloti.
[0331] Preference is also given to mixtures comprising as compound
II a biopesticide from group L5) selected from Azospirillum
amazonense SpY2, A. brasilense XOH, A. brasilense Sp245, A.
brasilense Cd, A. brasilense Ab-V5, A. brasilense Ab-V6, A.
lipoferum Sp31, Bradyrhizobium sp. (Vigna) PNL1, B. elkanii SEMIA
587, B. elkanii SEMIA 5019, B. japonicum SEMIA 5079, B. japonicum
SEMIA 5080, B. japonicum TA-11, B. japonicum 532c, B. simplex
herein more preferably strain ABU 288, Paenibacillus alvei NAS6G6,
Penicillium bilaiae strains ATCC 18309, ATCC 20851 and ATCC 22348;
Rhizobium leguminosarum bv. phaseoli RG-B10, R. I. bv. viciae
P1NP3Cst, R. I. bv. viciae RG-P2, R. I. bv. trifolii RP113-7, R. I.
bv. viciae SU303, R. I. bv. viciae WSM1455, R. tropici SEMIA 4077,
R. tropici PRF 81 and Sinorhizobium meliloti; even more preferably
selected from Azospirillum brasilense Sp245, Bradyrhizobium sp.
(Vigna) PNL1, B B. elkanii SEMIA 587, B. elkanii SEMIA 5019, B.
japonicum SEMIA 5079, B. japonicum SEMIA 5080, B. japonicum TA-11
and B. japonicum 532c.
[0332] According to a further embodiment, the at least one compound
II is Bacillus simplex, preferably B. simplex ABU 288. These
mixtures are particularly suitable in soybean and corn.
[0333] The present invention also relates to mixtures, wherein the
at least one compound II is selected from Azospirillum amazonense,
A. brasilense, A. lipoferum, A. irakense and A. halopraeferens,
more preferably from A. brasilense, in particular selected from A.
brasilense strains Sp245 and
[0334] AZ39 which are both commercially used in Brazil and are
obtainable from EMBRAPA-Agribiologia, Brazil, and strains Ab-V5 and
Ab-V6; in particular mixtures of these strains Ab-V5 and Ab-V6.
These mixtures are particularly suitable in soybean, especially as
seed treatment.
[0335] The present invention also relates to mixtures wherein the
at least one pesticide II is selected from A. amazonense, A.
brasilense, A. lipoferum, A. irakense and A. halopraeferens, more
preferably A. brasilense, and further comprises a compound III,
wherein compound III is selected from jasmonic acid, its salts and
derivatives thereof, preferably methyl-jasmonate or
cis-jasmone.
[0336] According to another embodiment of the inventive mixtures,
Bradyrhizobium spp. (meaning any Bradyrhizobium species and/or
strain) as compound II is B. japonicum. These mixtures are
particularly suitable in soybean. Certain B. japonicum strains have
been re-classified as a novel species B. elkanii; e.g. strain USDA
76 (Can. J. Microbiol. 38, 501-505, 1992). Bradyrhizobium spp. are
cultivated using media and fermentation techniques known in the
art, e.g. in yeast extract-mannitol broth (YEM) at 27.degree. C.
for about 5 days.
[0337] The present invention also relates to mixtures, wherein the
at least one compound II is selected from Bradyrhizobium spp., even
more preferably from B. sp. (Arachis), B. elkanii, B. japonicum,
liaoningense and B. lupini, and further comprises a compound III
(compound III, wherein compound III is selected from jasmonic acid,
its salts and derivatives thereof, preferably methyl-jasmonate or
cis-jasmone.
[0338] Preferably, B. japonicum is selected from strains E-109,
SEMIA 5079, SEMIA 5080, TA-11 and 532c. According to a further
embodiment, mixtures of B. japonicum strains TA-11 and 532c or B.
japonicum strains SEMIA 5079 and 5080 are used. The strains having
a prefix SEMIA are especially suitable for soybean grown in
Australia or South America, in particular in Brazil. More
preferably, mixtures of B. japonicum SEMIA 5079 and SEMIA 5080 are
used. B. japonicum WB74 is especially suitable for soybean grown in
South America and Africa, in particular in South Africa. Strain
E-109 is especially suitable for soybean grown in South America, in
particular in Argentina.
[0339] The present invention also relates to mixtures, wherein the
at least one compound II is selected from B. japonicum and further
comprises a compound III, wherein compound III is selected from
jasmonic acid, its salts and derivatives thereof, preferably
methyl-jasmonate or cis-jasmone.
[0340] The present invention also relates to mixtures, wherein the
at least one pesticide II is selected from Bradyrhizobium elkanii
and Bradyrhizobium liaoningense, more preferably from B. elkanii
even more preferably B. elkanii strains SEMIA 587 and SEMIA 5019;
in particular mixtures of both. These mixtures are particularly
suitable in soybean in Australia or South America, in particular in
Brazil.
[0341] The present invention also relates to mixtures, wherein
compound II is selected from Bradyrhizobium sp. (Arachis) and B.
sp. (Vigna) which shall describe the cowpea miscellany
cross-inoculation group which includes inter alia indigenous cowpea
bradyrhizobia on cowpea (Vigna unguiculata), siratro (Macroptilium
atropurpureum), lima bean (Phaseolus lunatus), and peanut (Arachis
hypogaea), in particular in particular B. sp. (Vigna) strain PNL1.
This mixture comprising as compound II B. sp. (Arachis) or B. sp.
(Vigna) is especially suitable for use in peanut, cowpea, Mung
bean, Moth bean, Dune bean, Rice bean, Snake bean and Creeping
vigna, in particular peanut.
[0342] The present invention also relates to mixtures, wherein the
at least one compound II is selected from Bradyrhizobium lupini
(also called B. sp. (Lupine), B. lupines or Rhizobium lupini).
These mixtures are especially suitable for use in dry beans and
lupins. Preferably, B. lupini is strain LL13. This strain is
especially suitable for lupins grown in Australia, North America or
Europe, in particular in Europe.
[0343] The present invention also relates to mixtures wherein the
at least one compound II is selected from Rhizobium leguminosarum
bv. phaseoli especially for the legume common bean (Phaseolus
vulgaris), but also for other for various legumes such as alfalfa,
clover, peas, beans, lentils, soybeans, peanuts and other crops
such as corn and lettuce, even more preferably strain RG-B10
thereof; R. I. bv. trifolii, especially strain RP113-7 thereof, R.
I. bv. viciae, in particular strains RG-P2, SU303, WSM1455 and
P1NP3Cst thereof, in particular P1NP3Cst; R. tropici, especially
strains CC511, CIAT 899 and PRF81 thereof; and Sinorhizobium
meliloti especially strain RCR2011 thereof. Further R. I. bv.
phaseoli or R. etli strains are e.g. known from the above mentioned
references and Appl. Environ. Microbiol. 45(3), 737-742, 1983;
ibida 54(5), 1280-1283, 1988.
[0344] According to a further embodiment, in the inventive mixtures
compound II is selected from Sinorhizobium meliloti more preferably
from RCR2011, S. meliloti NRG185, S. meliloti RRI128, S. meliloti
SU277,
[0345] R. tropici is useful for a range of legume crops especially
all kind of clovers e.g. in tropical regions such as Brazil.
Preferably, mixtures comprise as R. tropici at least one strain
selected from CC511, CIAT899, H12 and PRF 81.
[0346] The present invention also relates to mixtures wherein the
at least one compound II is selected from R. leguminosarum bv.
phaseoli, R. I. bv. trifolii, R. I. bv. viciae, R. tropici and
Sinorhizobium meliloti, and further comprises a compound III,
wherein compound III is selected from jasmonic acid, its salts and
derivatives thereof, preferably methyl-jasmonate or
cis-jasmone.
[0347] According to a further embodiment, the at least one compound
II is selected from Delftia acidovorans, in particular strain
RAY209, especially in soybean and canola.
[0348] With respect to their intended use in the methods of the
present invention, the following binary mixtures (B) listed in
tables 50 to 98 comprising one compound (I) and one compound (II)
are a preferred embodiment of the present invention.
TABLE-US-00002 TABLE 50 B I II B1 (I.A) L.1.1 B2 (I.A) L.1.2 B3
(I.A) L.1.3 B4 (I.A) L.1.4 B5 (I.A) L.1.5 B6 (I.A) L.1.6 B7 (I.A)
L.1.7 B8 (I.A) L.1.8 B9 (I.A) L.1.9 B10 (I.A) L.1.10 B11 (I.A)
L.1.11 B12 (I.A) L.1.12 B13 (I.A) L.1.13 B14 (I.A) L.1.14 B15 (I.A)
L.1.15 B16 (I.A) L.1.16 B17 (I.A) L.1.17 B18 (I.A) L.1.18 B19 (I.A)
L.1.19 B20 (I.A) L.1.20 B21 (I.A) L.1.21 B22 (I.A) L.1.22 B23 (I.A)
L.1.23 B24 (I.A) L.1.24 B25 (I.A) L.1.25 B26 (I.A) L.1.26 B27 (I.A)
L.1.27 B28 (I.A) L.1.28 B29 (I.A) L.1.29 B30 (I.A) L.1.30 B31 (I.A)
L.1.31 B32 (I.A) L.1.32 B33 (I.A) L.1.33 B34 (I.A) L.1.34 B35 (I.A)
L.1.35 B36 (I.A) L.1.36 B37 (I.A) L.1.37 B38 (I.A) L.1.38 B39 (I.A)
L.1.39 B40 (I.A) L.1.40 B41 (I.A) L.1.41 B42 (I.A) L.1.42 B43 (I.A)
L.1.43 B44 (I.A) L.1.44 B45 (I.A) L.1.45 B46 (I.A) L.1.46 B47 (I.A)
L.1.47 B48 (I.A) L.1.48 B49 (I.A) L.1.49 B50 (I.A) L.1.50 B51 (I.A)
L.1.51 B52 (I.A) L.1.52 B53 (I.A) L.1.53 B54 (I.A) L.1.54 B55 (I.A)
L.1.55 B56 (I.A) L.1.56 B57 (I.A) L.1.57 B58 (I.A) L.1.58 B59 (I.A)
L.1.59 B60 (I.A) L.1.60 B61 (I.A) L.1.61 B62 (I.A) L.1.62 B63 (I.A)
L.1.63 B64 (I.A) L.1.64 B65 (I.A) L.1.65 B66 (I.A) L.1.66 B67 (I.A)
L.1.67 B68 (I.A) L.1.68 B69 (I.A) L.1.69 B70 (I.A) L.1.70 B71 (I.A)
L.1.71 B72 (I.A) L.1.72 B73 (I.A) L.1.73 B74 (I.A) L.1.74 B75 (I.A)
L.1.75 B76 (I.A) L.1.76 B77 (I.A) L.1.77 B78 (I.A) L.1.78 B79 (I.A)
L.1.79 B80 (I.A) L.1.80 B81 (I.A) L.1.81 B82 (I.A) L.1.82 B83 (I.A)
L.1.83 B84 (I.A) L.1.84 B85 (I.A) L.1.85 B86 (I.A) L.1.86 B87 (I.A)
L.1.87 B88 (I.A) L.1.88 B89 (I.A) L.1.89 B90 (I.A) L.1.90 B91 (I.A)
L.1.91 B92 (I.A) L.1.92 B93 (I.A) L.1.93 B94 (I.A) L.1.94 B95 (I.A)
L.1.95 B96 (I.A) L.1.96 B97 (I.A) L.2.1 B98 (I.A) L.2.2 B99 (I.A)
L.2.3 B100 (I.A) L.2.4 B101 (I.A) L.2.5 B102 (I.A) L.2.6 B103 (I.A)
L.2.7 B104 (I.A) L.2.8 B105 (I.A) L.2.9 B106 (I.A) L.2.10 B107
(I.A) L.2.11 B108 (I.A) L.2.12 B109 (I.A) L.2.13 B110 (I.A) L.2.14
B111 (I.A) L.2.15 B112 (I.A) L.2.16 B113 (I.A) L.2.17 B114 (I.A)
L.2.18 B115 (I.A) L.2.19 B116 (I.A) L.2.20 B117 (I.A) L.2.21 B118
(I.A) L.2.22 B119 (I.A) L.2.23 B120 (I.A) L.2.24 B121 (I.A) L.2.25
B122 (I.A) L.2.26 B123 (I.A) L.2.27 B124 (I.A) L.2.28 B125 (I.A)
L.2.29 B126 (I.A) L.2.30 B127 (I.A) L.2.31 B128 (I.A) L.2.32 B129
(I.A) L.2.33 B130 (I.A) L.3.1 B131 (I.A) L.3.2 B132 (I.A) L.3.3
B133 (I.A) L.3.4 B134 (I.A) L.3.5 B135 (I.A) L.3.6 B136 (I.A) L.3.7
B137 (I.A) L.3.8 B138 (I.A) L.3.9 B139 (I.A) L.3.10 B140 (I.A)
L.3.11 B141 (I.A) L.3.12 B142 (I.A) L.3.13 B143 (I.A) L.3.14 B144
(I.A) L.3.15 B145 (I.A) L.3.16 B146 (I.A) L.3.17 B147 (I.A) L.3.18
B148 (I.A) L.3.19 B149 (I.A) L.3.20 B150 (I.A) L.3.21 B151 (I.A)
L.3.22 B152 (I.A) L.3.23 B153 (I.A) L.3.24 B154 (I.A) L.3.25 B155
(I.A) L.3.26 B156 (I.A) L.3.27 B157 (I.A) L.3.28 B158 (I.A) L.3.29
B159 (I.A) L.3.30 B160 (I.A) L.3.31 B161 (I.A) L.3.32 B162 (I.A)
L.3.33 B163 (I.A) L.3.34 B164 (I.A) L.3.35 B165 (I.A) L.3.36 B166
(I.A) L.3.37 B167 (I.A) L.3.38 B168 (I.A) L.3.39 B169 (I.A) L.3.40
B170 (I.A) L.3.41 B171 (I.A) L.3.42 B172 (I.A) L.3.43 B173 (I.A)
L.3.44 B174 (I.A) L.3.45 B175 (I.A) L.3.46 B176 (I.A) L.3.47 B177
(I.A) L.3.48 B178 (I.A) L.3.49 B179 (I.A) L.3.50 B180 (I.A) L.3.51
B181 (I.A) L.3.52 B182 (I.A) L.3.53 B183 (I.A) L.3.54 B184 (I.A)
L.3.55 B185 (I.A) L.3.56 B186 (I.A) L.3.57 B187 (I.A) L.3.58 B188
(I.A) L.3.59 B189 (I.A) L.3.60 B190 (I.A) L.3.61 B191 (I.A) L.3.62
B192 (I.A) L.3.63 B193 (I.A) L.3.1 B194 (I.A) L.3.2 B195 (I.A)
L.4.1 B196 (I.A) L.4.2 B197 (I.A) L.4.3 B198 (I.A) L.4.4 B199 (I.A)
L.4.5 B200 (I.A) L.4.6 B201 (I.A) L.4.7 B202 (I.A) L.4.8 B203 (I.A)
L.4.9 B204 (I.A) L.4.10 B205 (I.A) L.4.11 B206 (I.A) L.4.12 B207
(I.A) L.4.13 B208 (I.A) L.4.14 B209 (I.A) L.4.15 B210 (I.A) L.4.16
B211 (I.A) L.4.17 B212 (I.A) L.4.18 B213 (I.A) L.4.19 B214 (I.A)
L.4.20 B215 (I.A) L.4.21 B216 (I.A) L.4.22 B217 (I.A) L.4.23 B218
(I.A) L.4.24 B219 (I.A) L.4.25 B220 (I.A) L.4.26 B221 (I.A) L.4.27
B222 (I.A) L.4.28 B223 (I.A) L.4.29 B224 (I.A) L.4.30 B225 (I.A)
L.4.31 B226 (I.A) L.4.32 B227 (I.A) L.4.33 B228 (I.A) L.5.1 B229
(I.A) L.5.2 B230 (I.A) L.5.3 B231 (I.A) L.5.4 B232 (I.A) L.5.5 B233
(I.A) L.5.6 B234 (I.A) L.5.7 B235 (I.A) L.5.8 B236 (I.A) L.5.9 B237
(I.A) L.5.10 B238 (I.A) L.5.11 B239 (I.A) L.5.12 B240 (I.A) L.5.13
B241 (I.A) L.5.14 B242 (I.A) L.5.15 B243 (I.A) L.5.16 B244 (I.A)
L.5.17 B245 (I.A) L.5.18 B246 (I.A) L.5.19
B247 (I.A) L.5.20 B248 (I.A) L.5.21 B249 (I.A) L.5.22 B250 (I.A)
L.5.23 B251 (I.A) L.5.24 B252 (I.A) L.5.25 B253 (I.A) L.5.26 B254
(I.A) L.5.27 B255 (I.A) L.5.28 B256 (I.A) L.5.29 B257 (I.A) L.5.30
B258 (I.A) L.5.31 B259 (I.A) L.5.32 B260 (I.A) L.5.33 B261 (I.A)
L.5.34 B262 (I.A) L.5.35 B263 (I.A) L.5.36 B264 (I.A) L.5.37 B265
(I.A) L.5.38 B266 (I.A) L.5.39 B267 (I.A) L.5.40 B268 (I.A) L.5.41
B269 (I.A) L.5.42 B270 (I.A) L.5.43 B271 (I.A) L.5.44 B272 (I.A)
L.5.45 B273 (I.A) L.5.46 B274 (I.A) L.5.47 B275 (I.A) L.5.48 B276
(I.A) L.5.49 B277 (I.A) L.5.50 B278 (I.A) L.5.51 B279 (I.A) L.5.52
B280 (I.A) L.5.53 B281 (I.A) L.5.54 B282 (I.A) L.5.55 B283 (I.A)
L.5.56 B284 (I.A) L.5.57 B285 (I.A) L.5.58 B286 (I.A) L.5.59 B287
(I.A) L.5.60 B288 (I.A) L.5.61 B289 (I.A) L.5.62 B290 (I.A) L.5.63
B291 (I.A) L.5.64 B292 (I.A) L.5.65 B293 (I.A) L.5.66 B294 (I.A)
L.5.67 B295 (I.A) L.5.68 B296 (I.A) L.5.69 B297 (I.A) L.5.70 B298
(I.A) L.5.71 B299 (I.A) L.5.72 B300 (I.A) L.5.73 B301 (I.A) L.5.74
B302 (I.A) L.5.75 B301 (I.A) L.5.76 B304 (I.A) L.5.77 B305 (I.A)
L.5.78 B306 (I.A) L.5.79 B307 (I.A) L.5.80 B308 (I.A) L.5.81 B309
(I.A) L.5.82 B310 (I.A) L.5.83 B311 (I.A) L.5.84 B312 (I.A) L.6.1
B313 (I.A) L.6.2 B314 (I.A) L.6.3 B315 (I.A) L.6.4 B316 (I.A) L.6.5
B317 (I.A) L.6.6 B318 (I.A) L.6.7 B319 (I.A) L.6.8 B320 (I.A) L.6.9
B321 (I.A) L.6.10 B322 (I.A) L.6.11 B323 (I.A) L.6.12 B324 (I.A)
L.6.13 B325 (I.A) L.6.14 B326 (I.A) L.6.15 B327 (I.A) L.6.16 B328
(I.A) L.6.17 B329 (I.A) L.6.18 B = Mixture; I = compound I; II =
compound II
TABLE-US-00003 TABLE 51 B I II B330 (I.B) L.1.1 B331 (I.B) L.1.2
B332 (I.B) L.1.3 B333 (I.B) L.1.4 B334 (I.B) L.1.5 B335 (I.B) L.1.6
B336 (I.B) L.1.7 B337 (I.B) L.1.8 B338 (I.B) L.1.9 B339 (I.B)
L.1.10 B340 (I.B) L.1.11 B341 (I.B) L.1.12 B342 (I.B) L.1.13 B343
(I.B) L.1.14 B344 (I.B) L.1.15 B345 (I.B) L.1.16 B346 (I.B) L.1.17
B347 (I.B) L.1.18 B348 (I.B) L.1.19 B349 (I.B) L.1.20 B350 (I.B)
L.1.21 B351 (I.B) L.1.22 B352 (I.B) L.1.23 B353 (I.B) L.1.24 B354
(I.B) L.1.25 B355 (I.B) L.1.26 B356 (I.B) L.1.27 B357 (I.B) L.1.28
B358 (I.B) L.1.29 B359 (I.B) L.1.30 B360 (I.B) L.1.31 B361 (I.B)
L.1.32 B362 (I.B) L.1.33 B363 (I.B) L.1.34 B364 (I.B) L.1.35 B365
(I.B) L.1.36 B366 (I.B) L.1.37 B367 (I.B) L.1.38 B368 (I.B) L.1.39
B369 (I.B) L.1.40 B370 (I.B) L.1.41 B371 (I.B) L.1.42 B372 (I.B)
L.1.43 B373 (I.B) L.1.44 B374 (I.B) L.1.45 B375 (I.B) L.1.46 B376
(I.B) L.1.47 B377 (I.B) L.1.48 B378 (I.B) L.1.49 B379 (I.B) L.1.50
B380 (I.B) L.1.51 B381 (I.B) L.1.52 B382 (I.B) L.1.53 B383 (I.B)
L.1.54 B384 (I.B) L.1.55 B385 (I.B) L.1.56 B386 (I.B) L.1.57 B387
(I.B) L.1.58 B388 (I.B) L.1.59 B389 (I.B) L.1.60 B390 (I.B) L.1.61
B391 (I.B) L.1.62 B392 (I.B) L.1.63 B393 (I.B) L.1.64 B394 (I.B)
L.1.65 B395 (I.B) L.1.66 B396 (I.B) L.1.67 B397 (I.B) L.1.68 B398
(I.B) L.1.69 B399 (I.B) L.1.70 B400 (I.B) L.1.71 B401 (I.B) L.1.72
B402 (I.B) L.1.73 B403 (I.B) L.1.74 B404 (I.B) L.1.75 B405 (I.B)
L.1.76 B406 (I.B) L.1.77 B407 (I.B) L.1.78 B408 (I.B) L.1.79 B409
(I.B) L.1.80 B410 (I.B) L.1.81 B411 (I.B) L.1.82 B412 (I.B) L.1.83
B413 (I.B) L.1.84 B414 (I.B) L.1.85 B415 (I.B) L.1.86 B416 (I.B)
L.1.87 B417 (I.B) L.1.88 B418 (I.B) L.1.89 B419 (I.B) L.1.90 B420
(I.B) L.1.91 B421 (I.B) L.1.92 B422 (I.B) L.1.93 B423 (I.B) L.1.94
B424 (I.B) L.1.95 B425 (I.B) L.1.96 B426 (I.B) L.2.1 B427 (I.B)
L.2.2 B428 (I.B) L.2.3 B429 (I.B) L.2.4 B430 (I.B) L.2.5 B431 (I.B)
L.2.6 B432 (I.B) L.2.7 B433 (I.B) L.2.8 B434 (I.B) L.2.9 B435 (I.B)
L.2.10 B436 (I.B) L.2.11 B437 (I.B) L.2.12 B438 (I.B) L.2.13 B439
(I.B) L.2.14 B440 (I.B) L.2.15 B441 (I.B) L.2.16 B442 (I.B) L.2.17
B443 (I.B) L.2.18 B444 (I.B) L.2.19 B445 (I.B) L.2.20 B446 (I.B)
L.2.21 B447 (I.B) L.2.22 B448 (I.B) L.2.23 B449 (I.B) L.2.24 B450
(I.B) L.2.25 B451 (I.B) L.2.26 B452 (I.B) L.2.27 B453 (I.B) L.2.28
B454 (I.B) L.2.29 B455 (I.B) L.2.30 B456 (I.B) L.2.31 B457 (I.B)
L.2.32 B458 (I.B) L.2.33 B459 (I.B) L.3.1 B460 (I.B) L.3.2 B461
(I.B) L.3.3 B462 (I.B) L.3.4 B463 (I.B) L.3.5 B464 (I.B) L.3.6 B465
(I.B) L.3.7 B466 (I.B) L.3.8 B467 (I.B) L.3.9 B468 (I.B) L.3.10
B469 (I.B) L.3.11 B470 (I.B) L.3.12 B471 (I.B) L.3.13 B472 (I.B)
L.3.14 B473 (I.B) L.3.15 B474 (I.B) L.3.16 B475 (I.B) L.3.17 B476
(I.B) L.3.18 B477 (I.B) L.3.19 B478 (I.B) L.3.20 B479 (I.B) L.3.21
B480 (I.B) L.3.22 B481 (I.B) L.3.23 B482 (I.B) L.3.24 B483 (I.B)
L.3.25 B484 (I.B) L.3.26 B485 (I.B) L.3.27 B486 (I.B) L.3.28 B487
(I.B) L.3.29 B488 (I.B) L.3.30 B489 (I.B) L.3.31 B490 (I.B) L.3.32
B491 (I.B) L.3.33 B492 (I.B) L.3.34 B493 (I.B) L.3.35 B494 (I.B)
L.3.36 B495 (I.B) L.3.37 B496 (I.B) L.3.38 B497 (I.B) L.3.39 B498
(I.B) L.3.40 B499 (I.B) L.3.41 B500 (I.B) L.3.42 B501 (I.B) L.3.43
B502 (I.B) L.3.44 B503 (I.B) L.3.45 B504 (I.B) L.3.46 B505 (I.B)
L.3.47 B506 (I.B) L.3.48 B507 (I.B) L.3.49 B508 (I.B) L.3.50 B509
(I.B) L.3.51 B510 (I.B) L.3.52 B511 (I.B) L.3.53 B512 (I.B) L.3.54
B513 (I.B) L.3.55 B514 (I.B) L.3.56 B515 (I.B) L.3.57 B516 (I.B)
L.3.58 B517 (I.B) L.3.59 B518 (I.B) L.3.60 B519 (I.B) L.3.61 B520
(I.B) L.3.62 B521 (I.B) L.3.63 B522 (I.B) L.3.1 B523 (I.B) L.3.2
B524 (I.B) L.4.1 B525 (I.B) L.4.2 B526 (I.B) L.4.3 B527 (I.B) L.4.4
B528 (I.B) L.4.5 B529 (I.B) L.4.6 B530 (I.B) L.4.7 B531 (I.B) L.4.8
B532 (I.B) L.4.9 B533 (I.B) L.4.10 B534 (I.B) L.4.11 B535 (I.B)
L.4.12 B536 (I.B) L.4.13 B537 (I.B) L.4.14 B538 (I.B) L.4.15 B539
(I.B) L.4.16 B540 (I.B) L.4.17 B541 (I.B) L.4.18 B542 (I.B) L.4.19
B543 (I.B) L.4.20 B544 (I.B) L.4.21 B545 (I.B) L.4.22 B546 (I.B)
L.4.23 B547 (I.B) L.4.24 B548 (I.B) L.4.25 B549 (I.B) L.4.26 B550
(I.B) L.4.27 B551 (I.B) L.4.28 B552 (I.B) L.4.29 B553 (I.B) L.4.30
B554 (I.B) L.4.31 B555 (I.B) L.4.32 B556 (I.B) L.4.33 B557 (I.B)
L.5.1 B558 (I.B) L.5.2 B559 (I.B) L.5.3 B560 (I.B) L.5.4 B561 (I.B)
L.5.5 B562 (I.B) L.5.6 B563 (I.B) L.5.7 B564 (I.B) L.5.8 B565 (I.B)
L.5.9 B566 (I.B) L.5.10 B567 (I.B) L.5.11 B568 (I.B) L.5.12 B569
(I.B) L.5.13 B570 (I.B) L.5.14 B571 (I.B) L.5.15 B572 (I.B) L.5.16
B573 (I.B) L.5.17 B574 (I.B) L.5.18 B575 (I.B) L.5.19
B576 (I.B) L.5.20 B577 (I.B) L.5.21 B578 (I.B) L.5.22 B579 (I.B)
L.5.23 B580 (I.B) L.5.24 B581 (I.B) L.5.25 B582 (I.B) L.5.26 B583
(I.B) L.5.27 B584 (I.B) L.5.28 B585 (I.B) L.5.29 B586 (I.B) L.5.30
B587 (I.B) L.5.31 B588 (I.B) L.5.32 B589 (I.B) L.5.33 B590 (I.B)
L.5.34 B591 (I.B) L.5.35 B592 (I.B) L.5.36 B593 (I.B) L.5.37 B594
(I.B) L.5.38 B595 (I.B) L.5.39 B596 (I.B) L.5.40 B597 (I.B) L.5.41
B598 (I.B) L.5.42 B599 (I.B) L.5.43 B600 (I.B) L.5.44 B601 (I.B)
L.5.45 B602 (I.B) L.5.46 B603 (I.B) L.5.47 B604 (I.B) L.5.48 B605
(I.B) L.5.49 B606 (I.B) L.5.50 B607 (I.B) L.5.51 B608 (I.B) L.5.52
B609 (I.B) L.5.53 B610 (I.B) L.5.54 B611 (I.B) L.5.55 B612 (I.B)
L.5.56 B613 (I.B) L.5.57 B614 (I.B) L.5.58 B615 (I.B) L.5.59 B616
(I.B) L.5.60 B617 (I.B) L.5.61 B618 (I.B) L.5.62 B619 (I.B) L.5.63
B620 (I.B) L.5.64 B621 (I.B) L.5.65 B622 (I.B) L.5.66 B623 (I.B)
L.5.67 B624 (I.B) L.5.68 B625 (I.B) L.5.69 B626 (I.B) L.5.70 B627
(I.B) L.5.71 B628 (I.B) L.5.72 B629 (I.B) L.5.73 B630 (I.B) L.5.74
B631 (I.B) L.5.75 B632 (I.B) L.5.76 B633 (I.B) L.5.77 B634 (I.B)
L.5.78 B635 (I.B) L.5.79 B636 (I.B) L.5.80 B637 (I.B) L.5.81 B638
(I.B) L.5.82 B639 (I.B) L.5.83 B640 (I.B) L.5.84 B641 (I.B) L.6.1
B642 (I.B) L.6.2 B643 (I.B) L.6.3 B644 (I.B) L.6.4 B645 (I.B) L.6.5
B646 (I.B) L.6.6 B647 (I.B) L.6.7 B648 (I.B) L.6.8 B649 (I.B) L.6.9
B850 (I.B) L.6.10 B651 (I.B) L.6.11 B652 (I.B) L.6.12 B653 (I.B)
L.6.13 B654 (I.B) L.6.14 B655 (I.B) L.6.15 B656 (I.B) L.6.16 B657
(I.B) L.6.17 B658 (I.B) L.6.18 B = Mixture; I = compound I; II =
compound II
TABLE-US-00004 TABLE 52 B I II B659 (I.C) L.1.1 B660 (I.C) L.1.2
B661 (I.C) L.1.3 B662 (I.C) L.1.4 B663 (I.C) L.1.5 B664 (I.C) L.1.6
B665 (I.C) L.1.7 B666 (I.C) L.1.8 B667 (I.C) L.1.9 B668 (I.C)
L.1.10 B669 (I.C) L.1.11 B670 (I.C) L.1.12 B671 (I.C) L.1.13 B672
(I.C) L.1.14 B673 (I.C) L.1.15 B674 (I.C) L.1.16 B675 (I.C) L.1.17
B676 (I.C) L.1.18 B677 (I.C) L.1.19 B678 (I.C) L.1.20 B679 (I.C)
L.1.21 B680 (I.C) L.1.22 B681 (I.C) L.1.23 B682 (I.C) L.1.24 B683
(I.C) L.1.25 B684 (I.C) L.1.26 B685 (I.C) L.1.27 B686 (I.C) L.1.28
B687 (I.C) L.1.29 B688 (I.C) L.1.30 B689 (I.C) L.1.31 B690 (I.C)
L.1.32 B691 (I.C) L.1.33 B692 (I.C) L.1.34 B693 (I.C) L.1.35 B694
(I.C) L.1.36 B695 (I.C) L.1.37 B696 (I.C) L.1.38 B697 (I.C) L.1.39
B698 (I.C) L.1.40 B699 (I.C) L.1.41 B700 (I.C) L.1.42 B701 (I.C)
L.1.43 B702 (I.C) L.1.44 B703 (I.C) L.1.45 B704 (I.C) L.1.46 B705
(I.C) L.1.47 B706 (I.C) L.1.48 B707 (I.C) L.1.49 B708 (I.C) L.1.50
B709 (I.C) L.1.51 B710 (I.C) L.1.52 B711 (I.C) L.1.53 B712 (I.C)
L.1.54 B713 (I.C) L.1.55 B714 (I.C) L.1.56 B715 (I.C) L.1.57 B716
(I.C) L.1.58 B717 (I.C) L.1.59 B718 (I.C) L.1.60 B719 (I.C) L.1.61
B720 (I.C) L.1.62 B721 (I.C) L.1.63 B722 (I.C) L.1.64 B723 (I.C)
L.1.65 B724 (I.C) L.1.66 B725 (I.C) L.1.67 B726 (I.C) L.1.68 B727
(I.C) L.1.69 B728 (I.C) L.1.70 B729 (I.C) L.1.71 B730 (I.C) L.1.72
B731 (I.C) L.1.73 B732 (I.C) L.1.74 B733 (I.C) L.1.75 B734 (I.C)
L.1.76 B735 (I.C) L.1.77 B736 (I.C) L.1.78 B737 (I.C) L.1.79 B738
(I.C) L.1.80 B739 (I.C) L.1.81 B740 (I.C) L.1.82 B741 (I.C) L.1.83
B742 (I.C) L.1.84 B743 (I.C) L.1.85 B744 (I.C) L.1.86 B745 (I.C)
L.1.87 B746 (I.C) L.1.88 B747 (I.C) L.1.89 B748 (I.C) L.1.90 B749
(I.C) L.1.91 B750 (I.C) L.1.92 B751 (I.C) L.1.93 B752 (I.C) L.1.94
B753 (I.C) L.1.95 B754 (I.C) L.1.96 B755 (I.C) L.2.1 B756 (I.C)
L.2.2 B757 (I.C) L.2.3 B758 (I.C) L.2.4 B759 (I.C) L.2.5 B760 (I.C)
L.2.6 B761 (I.C) L.2.7 B762 (I.C) L.2.8 B763 (I.C) L.2.9 B764 (I.C)
L.2.10 B765 (I.C) L.2.11 B766 (I.C) L.2.12 B767 (I.C) L.2.13 B768
(I.C) L.2.14 B769 (I.C) L.2.15 B770 (I.C) L.2.16 B771 (I.C) L.2.17
B772 (I.C) L.2.18 B773 (I.C) L.2.19 B774 (I.C) L.2.20 B775 (I.C)
L.2.21 B776 (I.C) L.2.22 B777 (I.C) L.2.23 B778 (I.C) L.2.24 B779
(I.C) L.2.25 B780 (I.C) L.2.26 B781 (I.C) L.2.27 B782 (I.C) L.2.28
B783 (I.C) L.2.29 B784 (I.C) L.2.30 B785 (I.C) L.2.31 B786 (I.C)
L.2.32 B787 (I.C) L.2.33 B788 (I.C) L.3.1 B789 (I.C) L.3.2 B790
(I.C) L.3.3 B791 (I.C) L.3.4 B792 (I.C) L.3.5 B793 (I.C) L.3.6 B794
(I.C) L.3.7 B795 (I.C) L.3.8 B796 (I.C) L.3.9 B797 (I.C) L.3.10
B798 (I.C) L.3.11 B799 (I.C) L.3.12 B800 (I.C) L.3.13 B801 (I.C)
L.3.14 B802 (I.C) L.3.15 B803 (I.C) L.3.16 B804 (I.C) L.3.17 B805
(I.C) L.3.18 B806 (I.C) L.3.19 B807 (I.C) L.3.20 B808 (I.C) L.3.21
B809 (I.C) L.3.22 B810 (I.C) L.3.23 B811 (I.C) L.3.24 B812 (I.C)
L.3.25 B813 (I.C) L.3.26 B814 (I.C) L.3.27 B815 (I.C) L.3.28 B816
(I.C) L.3.29 B817 (I.C) L.3.30 B818 (I.C) L.3.31 B819 (I.C) L.3.32
B820 (I.C) L.3.33 B821 (I.C) L.3.34 B822 (I.C) L.3.35 B823 (I.C)
L.3.36 B824 (I.C) L.3.37 B825 (I.C) L.3.38 B826 (I.C) L.3.39 B827
(I.C) L.3.40 B828 (I.C) L.3.41 B829 (I.C) L.3.42 B830 (I.C) L.3.43
B831 (I.C) L.3.44 B832 (I.C) L.3.45 B833 (I.C) L.3.46 B834 (I.C)
L.3.47 B835 (I.C) L.3.48 B836 (I.C) L.3.49 B837 (I.C) L.3.50 B838
(I.C) L.3.51 B839 (I.C) L.3.52 B840 (I.C) L.3.53 B841 (I.C) L.3.54
B842 (I.C) L.3.55 B843 (I.C) L.3.56 B844 (I.C) L.3.57 B845 (I.C)
L.3.58 B846 (I.C) L.3.59 B847 (I.C) L.3.60 B848 (I.C) L.3.61 B849
(I.C) L.3.62 B850 (I.C) L.3.63 B851 (I.C) L.3.1 B852 (I.C) L.3.2
B853 (I.C) L.4.1 B854 (I.C) L.4.2 B855 (I.C) L.4.3 B856 (I.C) L.4.4
B857 (I.C) L.4.5 B858 (I.C) L.4.6 B859 (I.C) L.4.7 B860 (I.C) L.4.8
B861 (I.C) L.4.9 B862 (I.C) L.4.10 B863 (I.C) L.4.11 B864 (I.C)
L.4.12 B865 (I.C) L.4.13 B866 (I.C) L.4.14 B867 (I.C) L.4.15 B868
(I.C) L.4.16 B869 (I.C) L.4.17 B870 (I.C) L.4.18 B871 (I.C) L.4.19
B872 (I.C) L.4.20 B873 (I.C) L.4.21 B874 (I.C) L.4.22 B875 (I.C)
L.4.23 B876 (I.C) L.4.24 B877 (I.C) L.4.25 B878 (I.C) L.4.26 B879
(I.C) L.4.27 B880 (I.C) L.4.28 B881 (I.C) L.4.29 B882 (I.C) L.4.30
B883 (I.C) L.4.31 B884 (I.C) L.4.32 B885 (I.C) L.4.33 B886 (I.C)
L.5.1 B887 (I.C) L.5.2 B888 (I.C) L.5.3 B889 (I.C) L.5.4 B890 (I.C)
L.5.5 B891 (I.C) L.5.6 B892 (I.C) L.5.7 B893 (I.C) L.5.8 B894 (I.C)
L.5.9 B895 (I.C) L.5.10 B896 (I.C) L.5.11 B897 (I.C) L.5.12 B898
(I.C) L.5.13 B899 (I.C) L.5.14 B900 (I.C) L.5.15 B901 (I.C) L.5.16
B902 (I.C) L.5.17 B903 (I.C) L.5.18 B904 (I.C) L.5.19
B905 (I.C) L.5.20 B906 (I.C) L.5.21 B907 (I.C) L.5.22 B908 (I.C)
L.5.23 B909 (I.C) L.5.24 B910 (I.C) L.5.25 B911 (I.C) L.5.26 B912
(I.C) L.5.27 B913 (I.C) L.5.28 B914 (I.C) L.5.29 B915 (I.C) L.5.30
B916 (I.C) L.5.31 B917 (I.C) L.5.32 B918 (I.C) L.5.33 B919 (I.C)
L.5.34 B920 (I.C) L.5.35 B921 (I.C) L.5.36 B922 (I.C) L.5.37 B923
(I.C) L.5.38 B924 (I.C) L.5.39 B925 (I.C) L.5.40 B926 (I.C) L.5.41
B927 (I.C) L.5.42 B928 (I.C) L.5.43 B929 (I.C) L.5.44 B930 (I.C)
L.5.45 B931 (I.C) L.5.46 B932 (I.C) L.5.47 B933 (I.C) L.5.48 B934
(I.C) L.5.49 B935 (I.C) L.5.50 B936 (I.C) L.5.51 B937 (I.C) L.5.52
B938 (I.C) L.5.53 B939 (I.C) L.5.54 B940 (I.C) L.5.55 B941 (I.C)
L.5.56 B942 (I.C) L.5.57 B943 (I.C) L.5.58 B944 (I.C) L.5.59 B945
(I.C) L.5.60 B946 (I.C) L.5.61 B947 (I.C) L.5.62 B948 (I.C) L.5.63
B949 (I.C) L.5.64 B950 (I.C) L.5.65 B951 (I.C) L.5.66 B952 (I.C)
L.5.67 B953 (I.C) L.5.68 B954 (I.C) L.5.69 B955 (I.C) L.5.70 B956
(I.C) L.5.71 B957 (I.C) L.5.72 B958 (I.C) L.5.73 B959 (I.C) L.5.74
B960 (I.C) L.5.75 B961 (I.C) L.5.76 B962 (I.C) L.5.77 B963 (I.C)
L.5.78 B964 (I.C) L.5.79 B965 (I.C) L.5.80 B966 (I.C) L.5.81 B967
(I.C) L.5.82 B968 (I.C) L.5.83 B969 (I.C) L.5.84 B970 (I.C) L.6.1
B971 (I.C) L.6.2 B972 (I.C) L.6.3 B973 (I.C) L.6.4 B974 (I.C) L.6.5
B975 (I.C) L.6.6 B976 (I.C) L.6.7 B977 (I.C) L.6.8 B978 (I.C) L.6.9
B979 (I.C) L.6.10 B980 (I.C) L.6.11 B981 (I.C) L.6.12 B982 (I.C)
L.6.13 B983 (I.C) L.6.14 B984 (I.C) L.6.15 B985 (I.C) L.6.16 B986
(I.C) L.6.17 B987 (I.C) L.6.18 B = Mixture; I = compound I; II =
compound II
TABLE-US-00005 TABLE 53 B I II B988 (I.D) L.1.1 B989 (I.D) L.1.2
B990 (I.D) L.1.3 B991 (I.D) L.1.4 B992 (I.D) L.1.5 B993 (I.D) L.1.6
B994 (I.D) L.1.7 B995 (I.D) L.1.8 B996 (I.D) L.1.9 B997 (I.D)
L.1.10 B998 (I.D) L.1.11 B999 (I.D) L.1.12 B1000 (I.D) L.1.13 B1001
(I.D) L.1.14 B1002 (I.D) L.1.15 B1003 (I.D) L.1.16 B1004 (I.D)
L.1.17 B1005 (I.D) L.1.18 B1006 (I.D) L.1.19 B1007 (I.D) L.1.20
B1008 (I.D) L.1.21 B1009 (I.D) L.1.22 B1010 (I.D) L.1.23 B1011
(I.D) L.1.24 B1012 (I.D) L.1.25 B1013 (I.D) L.1.26 B1014 (I.D)
L.1.27 B1015 (I.D) L.1.28 B1016 (I.D) L.1.29 B1017 (I.D) L.1.30
B1018 (I.D) L.1.31 B1019 (I.D) L.1.32 B1020 (I.D) L.1.33 B1021
(I.D) L.1.34 B1022 (I.D) L.1.35 B1023 (I.D) L.1.36 B1024 (I.D)
L.1.37 B1025 (I.D) L.1.38 B1026 (I.D) L.1.39 B1027 (I.D) L.1.40
B1028 (I.D) L.1.41 B1029 (I.D) L.1.42 B1030 (I.D) L.1.43 B1031
(I.D) L.1.44 B1032 (I.D) L.1.45 B1033 (I.D) L.1.46 B1034 (I.D)
L.1.47 B1035 (I.D) L.1.48 B1036 (I.D) L.1.49 B1037 (I.D) L.1.50
B1038 (I.D) L.1.51 B1039 (I.D) L.1.52 B1040 (I.D) L.1.53 B1041
(I.D) L.1.54 B1042 (I.D) L.1.55 B1043 (I.D) L.1.56 B1044 (I.D)
L.1.57 B1045 (I.D) L.1.58 B1046 (I.D) L.1.69 B1047 (I.D) L.1.60
B1048 (I.D) L.1.61 B1049 (I.D) L.1.62 B1050 (I.D) L.1.63 B1051
(I.D) L.1.64 B1052 (I.D) L.1.65 B1053 (I.D) L.1.66 B1054 (I.D)
L.1.67 B1055 (I.D) L.1.68 B1056 (I.D) L.1.69 B1057 (I.D) L.1.70
B1058 (I.D) L.1.71 B1059 (I.D) L.1.72 B1060 (I.D) L.1.73 B1061
(I.D) L.1.74 B1062 (I.D) L.1.75 B1063 (I.D) L.1.76 B1064 (I.D) L.1
77 B1065 (I.D) L.1.78 B1066 (I.D) L.1.79 B1067 (I.D) L.1.80 B1068
(I.D) L.1.81 B1069 (I.D) L.1.82 B1070 (I.D) L.1.83 B1071 (I.D)
L.1.84 B1072 (I.D) L.1.85 B1073 (I.D) L.1.86 B1074 (I.D) L.1.87
B1075 (I.D) L.1.88 B1076 (I.D) L.1.89 B1077 (I.D) L.1.90 B1078
(I.D) L.1.91 B1079 (I.D) L.1.92 B1080 (I.D) L.1.93 B1081 (I.D)
L.1.94 B1082 (I.D) L.1.95 B1083 (I.D) L.1.96 B1084 (I.D) L.2.1
B1085 (I.D) L.2.2 B1086 (I.D) L.2.3 B1087 (I.D) L.2.4 B1088 (I.D)
L.2.5 B1089 (I.D) L.2.6 B1090 (I.D) L.2.7 B1091 (I.D) L.2.8 B1092
(I.D) L.2.9 B1093 (I.D) L.2.10 B1094 (I.D) L.2.11 B1095 (I.D)
L.2.12 B1096 (I.D) L.2.13 B1097 (I.D) L.2.14 B1098 (I.D) L.2.15
B1099 (I.D) L.2.16 B1100 (I.D) L.2.17 B1101 (I.D) L.2.18 B1102
(I.D) L.2.19 B1103 (I.D) L.2.20 B1104 (I.D) L.2.21 B1105 (I.D)
L.2.22 B1106 (I.D) L.2.23 B1107 (I.D) L.2.24 B1108 (I.D) L.2.25
B1109 (I.D) L.2.26 B1110 (I.D) L.2.27 B1111 (I.D) L.2.28 B1112
(I.D) L.2.29 B1113 (I.D) L.2.30 B1114 (I.D) L.2.31 B1115 (I.D)
L.2.32 B1116 (I.D) L.2.33 B1117 (I.D) L.3.1 B1118 (I.D) L.3.2 B1119
(I.D) L.3.3 B1120 (I.D) L.3.4 B1121 (I.D) L.3.5 B1122 (I.D) L.3.6
B1123 (I.D) L.3.7 B1124 (I.D) L.3.8 B1125 (I.D) L.3.9 B1126 (I.D)
L.3.10 B1127 (I.D) L.3.11 B1128 (I.D) L.3.12 B1129 (I.D) L.3.13
B1130 (I.D) L.3.14 B1131 (I.D) L.3.15 B1132 (I.D) L.3.16 B1133
(I.D) L.3.17 B1134 (I.D) L.3.18 B1135 (I.D) L.3.19 B1136 (I.D)
L.3.20 B1137 (I.D) L.3.21 B1138 (I.D) L.3.22 B1139 (I.D) L.3.23
B1140 (I.D) L.3.24 B1141 (I.D) L.3.25 B1142 (I.D) L.3.28 B1143
(I.D) L.3.27 B1144 (I.D) L.3.28 B1145 (I.D) L.3.29 B1146 (I.D)
L.3.30 B1147 (I.D) L.3.31 B1148 (I.D) L.3.32 B1149 (I.D) L.3.33
B1150 (I.D) L.3.34 B1151 (I.D) L.3.35 B1152 (I.D) L.3.36 B1153
(I.D) L.3.37 B1154 (I.D) L.3.38 B1155 (I.D) L.3.39 B1156 (I.D)
L.3.40 B1157 (I.D) L.3.41 B1158 (I.D) L.3.42 B1159 (I.D) L.3.43
B1160 (I.D) L.3.44 B1161 (I.D) L.3.45 B1162 (I.D) L.3.46 B1163
(I.D) L.3.47 B1164 (I.D) L.3.48 B1165 (I.D) L.3.49 B1166 (I.D)
L.3.50 B1167 (I.D) L.3.51 B1168 (I.D) L.3.52 B1169 (I.D) L.3.53
B1170 (I.D) L.3.54 B1171 (I.D) L.3.55 B1172 (I.D) L.3.56 B1173
(I.D) L.3.57 B1174 (I.D) L.3.58 B1175 (I.D) L.3.59 B1176 (I.D)
L.3.60 B1177 (I.D) L.3.61 B1178 (I.D) L.3.62 B1179 (I.D) L.3.63
B1180 (I.D) L.3.1 B1181 (I.D) L.3.2 B1182 (I.D) L.4.1 B1183 (I.D)
L.4.2 B1184 (I.D) L.4.3 B1185 (I.D) L.4.4 B1186 (I.D) L.4.5 B1187
(I.D) L.4.6 B1188 (I.D) L.4.7 B1189 (I.D) L.4.8 B1190 (I.D) L.4.9
B1191 (I.D) L.4.10 B1192 (I.D) L.4.11 B1193 (I.D) L.4.12 B1194
(I.D) L.4.13 B1195 (I.D) L.4.14 B1196 (I.D) L.4.15 B1197 (I.D)
L.4.16 B1198 (I.D) L.4.17 B1199 (I.D) L.4.18 B1200 (I.D) L.4.19
B1201 (I.D) L.4.20 B1202 (I.D) L.4.21 B1203 (I.D) L.4.22 B1204
(I.D) L.4.23 B1205 (I.D) L.4.24 B1206 (I.D) L.4.25 B1207 (I.D)
L.4.26 B1208 (I.D) L.4.27 B1209 (I.D) L.4.28 B1210 (I.D) L.4.29
B1211 (I.D) L.4.30 B1212 (I.D) L.4.31 B1213 (I.D) L.4.32 B1214
(I.D) L.4.33 B1215 (I.D) L.5.1 B1216 (I.D) L.5.2 B1217 (I.D) L.5.3
B1218 (I.D) L.5.4 B1219 (I.D) L.5.5 B1220 (I.D) L.5.6 B1221 (I.D)
L.5.7 B1222 (I.D) L.5.8 B1223 (I.D) L.5.9 B1224 (I.D) L.5.10 B1225
(I.D) L.5.11 B1226 (I.D) L.5.12 B1227 (I.D) L.5.13 B1228 (I.D)
L.5.14 B1229 (I.D) L.5.15 B1230 (I.D) L.5.16 B1231 (I.D) L.5.17
B1232 (I.D) L.5.18 B1233 (I.D) L.5.19
B1234 (I.D) L.5.20 B1235 (I.D) L.5.21 B1236 (I.D) L.5.22 B1237
(I.D) L.5.23 B1238 (I.D) L.5.24 B1239 (I.D) L.5.25 B1240 (I.D)
L.5.26 B1241 (I.D) L.5.27 B1242 (I.D) L.5.28 B1243 (I.D) L.5.29
B1244 (I.D) L.5.30 B1245 (I.D) L.5.31 B1246 (I.D) L.5.32 B1247
(I.D) L.5.33 B1248 (I.D) L.5.34 B1249 (I.D) L.5.35 B1250 (I.D)
L.5.36 B1251 (I.D) L.5.37 B1252 (I.D) L.5.38 B1253 (I.D) L.5.39
B1254 (I.D) L.5.40 B1255 (I.D) L.5.41 B1256 (I.D) L.5.42 B1257
(I.D) L.5.43 B1258 (I.D) L.5.44 B1259 (I.D) L.5.45 B1260 (I.D)
L.5.46 B1261 (I.D) L.5.47 B1262 (I.D) L.5.48 B1263 (I.D) L.5.49
B1264 (I.D) L.5.50 B1265 (I.D) L.5.51 B1266 (I.D) L.5.52 B1267
(I.D) L.5.53 B1268 (I.D) L.5.54 B1269 (I.D) L.5.55 B1270 (I.D)
L.5.56 B1271 (I.D) L.5.57 B1272 (I.D) L.5.58 B1273 (I.D) L.5.59
B1274 (I.D) L.5.60 B1275 (I.D) L.5.61 B1276 (I.D) L.5.62 B1277
(I.D) L.5.63 B1278 (I.D) L.5.64 B1279 (I.D) L.5.65 B1280 (I.D)
L.5.66 B1281 (I.D) L.5.67 B1282 (I.D) L.5.68 B1283 (I.D) L.5.69
B1284 (I.D) L.5.70 B1285 (I.D) L.5.71 B1286 (I.D) L.5.72 B1287
(I.D) L.5.73 B1288 (I.D) L.5.74 B1289 (I.D) L.5.75 B1290 (I.D)
L.5.76 B1291 (I.D) L.5.77 B1292 (I.D) L.5.78 B1293 (I.D) L.5.79
B1294 (I.D) L.5.80 B1295 (I.D) L.5.81 B1296 (I.D) L.5.82 B1297
(I.D) L.5.83 B1298 (I.D) L.5.84 B1299 (I.D) L.6.1 B1300 (I.D) L.6.2
B1301 (I.D) L.6.3 B1302 (I.D) L.6.4 B1303 (I.D) L.6.5 B1304 (I.D)
L.6.6 B1305 (I.D) L.6.7 B1306 (I.D) L.6.8 B1307 (I.D) L.6.9 B1308
(I.D) L.6.10 B1309 (I.D) L.6.11 B1310 (I.D) L.6.12 B1311 (I.D)
L.6.13 B1312 (I.D) L.6.14 B1313 (I.D) L.6.15 B1314 (I.D) L.6.16
B1315 (I.D) L.6.17 B1316 (I.D) L.6.18 B = Mixture; I = compound I;
II = compound II
TABLE-US-00006 TABLE 54 B I II B1317 (I.E) L.1.1 B1318 (I.E) L.1.2
B1319 (I.E) L.1.3 B1320 (I.E) L.1.4 B1321 (I.E) L.1.5 B1322 (I.E)
L.1.6 B1323 (I.E) L.1.7 B1324 (I.E) L.1.8 B1325 (I.E) L.1.9 B1326
(I.E) L.1.10 B1327 (I.E) L.1.11 B1328 (I.E) L.1.12 B1329 (I.E)
L.1.13 B1330 (I.E) L.1.14 B1331 (I.E) L.1.15 B1332 (I.E) L.1.16
B1333 (I.E) L.1.17 B1334 (I.E) L.1.18 B1335 (I.E) L.1.19 B1336
(I.E) L.1.20 B1337 (I.E) L.1.21 B1338 (I.E) L.1.22 B1339 (I.E)
L.1.23 B1340 (I.E) L.1.24 B1341 (I.E) L.1.25 B1342 (I.E) L.1.26
B1343 (I.E) L.1.27 B1344 (I.E) L.1.28 B1345 (I.E) L.1.29 B1346
(I.E) L.1.30 B1347 (I.E) L.1.31 B1348 (I.E) L.1.32 B1349 (I.E)
L.1.33 B1350 (I.E) L.1.34 B1351 (I.E) L.1.35 B1352 (I.E) L.1.36
B1353 (I.E) L.1.37 B1354 (I.E) L.1.38 B1355 (I.E) L.1.39 B1356
(I.E) L.1.40 B1357 (I.E) L.1.41 B1358 (I.E) L.1.42 B1359 (I.E)
L.1.43 B1360 (I.E) L.1.44 B1361 (I.E) L.1.45 B1362 (I.E) L.1.46
B1363 (I.E) L.1.47 B1364 (I.E) L.1.48 B1365 (I.E) L.1.49 B1366
(I.E) L.1.50 B1367 (I.E) L.1.51 B1368 (I.E) L.1.52 B1369 (I.E)
L.1.53 B1370 (I.E) L.1.54 B1371 (I.E) L.1.55 B1372 (I.E) L.1.56
B1373 (I.E) L.1.57 B1374 (I.E) L.1.58 B1375 (I.E) L.1.59 B1376
(I.E) L.1.60 B1377 (I.E) L.1.61 B1378 (I.E) L.1.62 B1379 (I.E)
L.1.63 B1380 (I.E) L.1.64 B1381 (I.E) L.1.65 B1382 (I.E) L.1.66
B1383 (I.E) L.1.67 B1384 (I.E) L.1.68 B1385 (I.E) L.1.69 B1386
(I.E) L.1.70 B1387 (I.E) L.1.71 B1388 (I.E) L.1.72 B1389 (I.E)
L.1.73 B1390 (I.E) L.1.74 B1391 (I.E) L.1.75 B1392 (I.E) L.1.76
B1393 (I.E) L.1.77 B1394 (I.E) L.1.78 B1395 (I.E) L.1.79 B1396
(I.E) L.1.80 B1397 (I.E) L.1.81 B1398 (I.E) L.1.82 B1399 (I.E)
L.1.83 B1400 (I.E) L.1.84 B1401 (I.E) L.1.85 B1402 (I.E) L.1.86
B1403 (I.E) L.1.87 B1404 (I.E) L.1.88 B1405 (I.E) L.1.89 B1406
(I.E) L.1.90 B1407 (I.E) L.1.91 B1408 (I.E) L.1.92 B1409 (I.E)
L.1.93 B1410 (I.E) L.1.94 B1411 (I.E) L.1.95 B1412 (I.E) L.1.96
B1413 (I.E) L.2.1 B1414 (I.E) L.2.2 B1415 (I.E) L.2.3 B1416 (I.E)
L.2.4 B1417 (I.E) L.2.5 B1418 (I.E) L.2.6 B1419 (I.E) L.2.7 B1420
(I.E) L.2.8 B1421 (I.E) L.2.9 B1422 (I.E) L.2.10 B1423 (I.E) L.2.11
B1424 (I.E) L.2.12 B1425 (I.E) L.2.13 B1426 (I.E) L.2.14 B1427
(I.E) L.2.15 B1428 (I.E) L.2.16 B1429 (I.E) L.2.17 B1430 (I.E)
L.2.18 B1431 (I.E) L.2.19 B1432 (I.E) L.2.20 B1433 (I.E) L.2.21
B1434 (I.E) L.2.22 B1435 (I.E) L.2.23 B1436 (I.E) L.2.24 B1437
(I.E) L.2.25 B1438 (I.E) L.2.26 B1439 (I.E) L.2.27 B1440 (I.E)
L.2.28 B1441 (I.E) L.2.29 B1442 (I.E) L.2.30 B1443 (I.E) L.2.31
B1444 (I.E) L.2.32 B1445 (I.E) L.2.33 B1446 (I.E) L.3.1 B1447 (I.E)
L.3.2 B1448 (I.E) L.3.3 B1449 (I.E) L.3.4 B1450 (I.E) L.3.5 B1451
(I.E) L.3.6 B1452 (I.E) L.3.7 B1453 (I.E) L.3.8 B1454 (I.E) L.3.9
B1455 (I.E) L.3.10 B1456 (I.E) L.3.11 B1457 (I.E) L.3.12 B1458
(I.E) L.3.13 B1459 (I.E) L.3.14 B1460 (I.E) L.3.15 B1461 (I.E)
L.3.16 B1462 (I.E) L.3.17 B1463 (I.E) L.3.18 B1464 (I.E) L.3.19
B1465 (I.E) L.3.20 B1466 (I.E) L.3.21 B1467 (I.E) L.3.22 B1468
(I.E) L.3.23 B1469 (I.E) L.3.24 B1470 (I.E) L.3.25 B1471 (I.E)
L.3.26 B1472 (I.E) L.3.27 B1473 (I.E) L.3.28 B1474 (I.E) L.3.29
B1475 (I.E) L.3.30 B1476 (I.E) L.3.31 B1477 (I.E) L.3.32 B1478
(I.E) L.3.33 B1479 (I.E) L.3.34 B1480 (I.E) L.3.35 B1481 (I.E)
L.3.36 B1482 (I.E) L.3.37 B1483 (I.E) L.3.38 B1484 (I.E) L.3.39
B1485 (I.E) L.3.40 B1486 (I.E) L.3.41 B1487 (I.E) L.3.42 B1488
(I.E) L.3.43 B1489 (I.E) L.3.44 B1490 (I.E) L.3.45 B1491 (I.E)
L.3.46 B1492 (I.E) L.3.47 B1493 (I.E) L.3.48 B1494 (I.E) L.3.49
B1495 (I.E) L.3.50 B1496 (I.E) L.3.51 B1497 (I.E) L.3.52 B1498
(I.E) L.3.53 B1499 (I.E) L.3.54 B1500 (I.E) L.3.55 B1501 (I.E)
L.3.56 B1502 (I.E) L.3.57 B1503 (I.E) L.3.58 B1504 (I.E) L.3.59
B1505 (I.E) L.3.60 B1506 (I.E) L.3.61 B1507 (I.E) L.3.62 B1508
(I.E) L.3.63 B1509 (I.E) L.3.1 B1510 (I.E) L.3.2 B1511 (I.E) L.4.1
B1512 (I.E) L.4.2 B1513 (I.E) L.4.3 B1514 (I.E) L.4.4 B1515 (I.E)
L.4.5 B1516 (I.E) L.4.6 B1517 (I.E) L.4.7 B1518 (I.E) L.4.8 B1519
(I.E) L.4.9 B1520 (I.E) L.4.10 B1521 (I.E) L.4.11 B1522 (I.E)
L.4.12 B1523 (I.E) L.4.13 B1524 (I.E) L.4.14 B1525 (I.E) L.4.15
B1526 (I.E) L.4.16 B1527 (I.E) L.4.17 B1528 (I.E) L.4.18 B1529
(I.E) L.4.19 B1530 (I.E) L.4.20 B1531 (I.E) L.4.21 B1532 (I.E)
L.4.22 B1533 (I.E) L.4.23 B1534 (I.E) L.4.24 B1535 (I.E) L.4.25
B1536 (I.E) L.4.26 B1537 (I.E) L.4.27 B1538 (I.E) L.4.28 B1539
(I.E) L.4.29 B1540 (I.E) L.4.30 B1541 (I.E) L.4.31 B1542 (I.E)
L.4.32 B1543 (I.E) L.4.33 B1544 (I.E) L.5.1 B1545 (I.E) L.5.2 B1546
(I.E) L.5.3 B1547 (I.E) L.5.4 B1548 (I.E) L.5.5 B1549 (I.E) L.5.6
B1550 (I.E) L.5.7 B1551 (I.E) L.5.8 B1552 (I.E) L.5.9 B1553 (I.E)
L.5.10 B1554 (I.E) L.5.11 B1555 (I.E) L.5.12 B1556 (I.E) L.5.13
B1557 (I.E) L.5.14 B1558 (I.E) L.5.15 B1559 (I.E) L.5.16 B1560
(I.E) L.5.17 B1561 (I.E) L.5.18 B1562 (I.E) L.5.19
B1563 (I.E) L.5.20 B1564 (I.E) L.5.21 B1565 (I.E) L.5.22 B1566
(I.E) L.5.23 B1567 (I.E) L.5.24 B1568 (I.E) L.5.25 B1569 (I.E)
L.5.26 B1570 (I.E) L.5.27 B1571 (I.E) L.5.28 B1572 (I.E) L.5.29
B1573 (I.E) L.5.30 B1574 (I.E) L.5.31 B1575 (I.E) L.5.32 B1576
(I.E) L.5.33 B1577 (I.E) L.5.34 B1578 (I.E) L.5.35 B1579 (I.E)
L.5.36 B1580 (I.E) L.5.37 B1581 (I.E) L.5.38 B1582 (I.E) L.5.39
B1583 (I.E) L.5.40 B1584 (I.E) L.5.41 B1585 (I.E) L.5.42 B1586
(I.E) L.5.43 B1587 (I.E) L.5.44 B1588 (I.E) L.5.45 B1589 (I.E)
L.5.46 B1590 (I.E) L.5.47 B1591 (I.E) L.5.48 B1592 (I.E) L.5.49
B1593 (I.E) L.5.50 B1594 (I.E) L.5.51 B1595 (I.E) L.5.52 B1596
(I.E) L.5.53 B1597 (I.E) L.5.54 B1598 (I.E) L.5.55 B1599 (I.E)
L.5.56 B1600 (I.E) L.5.57 B1601 (I.E) L.5.58 B1602 (I.E) L.5.59
B1603 (I.E) L.5.60 B1604 (I.E) L.5.61 B1605 (I.E) L.5.62 B1606
(I.E) L.5.63 B1607 (I.E) L.5.64 B1608 (I.E) L.5.65 B1609 (I.E)
L.5.66 B1610 (I.E) L.5.67 B1611 (I.E) L.5.68 B1612 (I.E) L.5.69
B1613 (I.E) L.5.70 B1614 (I.E) L.5.71 B1615 (I.E) L.5.72 B1616
(I.E) L.5.73 B1617 (I.E) L.5.74 B1618 (I.E) L.5.75 B1619 (I.E)
L.5.76 B1620 (I.E) L.5.77 B1621 (I.E) L.5.78 B1622 (I.E) L.5.79
B1623 (I.E) L.5.80 B1624 (I.E) L.5.81 B1625 (I.E) L.5.82 B1626
(I.E) L.5.83 B1627 (I.E) L.5.84 B1628 (I.E) L.6.1 B1629 (I.E) L.6.2
B1630 (I.E) L.6.3 B1631 (I.E) L.6.4 B1632 (I.E) L.6.5 B1633 (I.E)
L.6.6 B1634 (I.E) L.6.7 B1635 (I.E) L.6.8 B1636 (I.E) L.6.9 B1637
(I.E) L.6.10 B1638 (I.E) L.6.11 B1639 (I.E) L.6.12 B1640 (I.E)
L.6.13 B1641 (I.E) L.6.14 B1642 (I.E) L.6.15 B1643 (I.E) L.6.16
B1644 (I.E) L.6.17 B1645 (I.E) L.6.18 B = Mixture; I = compound I;
II = compound II
TABLE-US-00007 TABLE 55 B I II B1646 (I.F) L.1.1 B1647 (I.F) L.1.2
B1648 (I.F) L.1.3 B1649 (I.F) L.1.4 B1650 (I.F) L.1.5 B1651 (I.F)
L.1.6 B1652 (I.F) L.1.7 B1653 (I.F) L.1.8 B1654 (I.F) L.1.9 B1655
(I.F) L.1.10 B1656 (I.F) L.1.11 B1657 (I.F) L.1.12 B1658 (I.F)
L.1.13 B1659 (I.F) L.1.14 B1660 (I.F) L.1.15 B1661 (I.F) L.1.16
B1662 (I.F) L.1.17 B1663 (I.F) L.1.18 B1664 (I.F) L.1.19 B1665
(I.F) L.1.20 B1666 (I.F) L.1.21 B1667 (I.F) L.1.22 B1668 (I.F)
L.1.23 B1669 (I.F) L.1.24 B1670 (I.F) L.1.25 B1671 (I.F) L.1.26
B1672 (I.F) L.1.27 B1673 (I.F) L.1.28 B1674 (I.F) L.1.29 B1675
(I.F) L.1.30 B1676 (I.F) L.1.31 B1677 (I.F) L.1.32 B1678 (I.F)
L.1.33 B1679 (I.F) L.1.34 B1680 (I.F) L.1.35 B1681 (I.F) L.1.36
B1682 (I.F) L.1.37 B1683 (I.F) L.1.38 B1684 (I.F) L.1.39 B1685
(I.F) L.1.40 B1686 (I.F) L.1.41 B1687 (I.F) L.1.42 B1688 (I.F)
L.1.43 B1689 (I.F) L.1.44 B1690 (I.F) L.1.45 B1691 (I.F) L.1.46
B1692 (I.F) L.1.47 B1693 (I.F) L.1.48 B1694 (I.F) L.1.49 B1695
(I.F) L.1.50 B1696 (I.F) L.1.51 B1697 (I.F) L.1.52 B1698 (I.F)
L.1.53 B1699 (I.F) L.1.54 B1700 (I.F) L.1.55 B1701 (I.F) L.1.56
B1702 (I.F) L.1.57 B1703 (I.F) L.1.58 B1704 (I.F) L.1.59 B1705
(I.F) L.1.60 B1706 (I.F) L.1.61 B1707 (I.F) L.1.62 B1708 (I.F)
L.1.63 B1709 (I.F) L.1.64 B1710 (I.F) L.1.65 B1711 (I.F) 1.1.66
B1712 (I.F) L.1.67 B1713 (I.F) L.1.68 B1714 (I.F) L.1.69 B1715
(I.F) L.1.70 B1716 (I.F) L.1.71 B1717 (I.F) L.1.72 B1718 (I.F)
L.1.73 B1719 (I.F) L.1.74 B1720 (I.F) L.1.75 B1721 (I.F) L.1.76
B1722 (I.F) L.1.77 B1723 (I.F) L.1.78 B1724 (I.F) L.1.79 B1725
(I.F) L.1.80 B1726 (I.F) L.1.81 B1727 (I.F) L.1.82 B1728 (I.F)
L.1.83 B1729 (I.F) L.1.84 B1730 (I.F) L.1.85 B1731 (I.F) L.1.86
B1732 (I.F) L.1.87 B1733 (I.F) L.1.88 B1734 (I.F) L.1.89 B1735
(I.F) L.1.90 B1736 (I.F) L.1.91 B1737 (I.F) L.1.92 B1738 (I.F)
L.1.93 B1739 (I.F) L.1.94 B1740 (I.F) L.1.95 B1741 (I.F) L.1.96
B1742 (I.F) L.2.1 B1743 (I.F) L.2.2 B1744 (I.F) L.2.3 B1745 (I.F)
L.2.4 B1746 (I.F) L.2.5 B1747 (I.F) L.2.6 B1748 (I.F) L.2.7 B1749
(I.F) L.2.8 B1750 (I.F) L.2.9 B1751 (I.F) L.2.10 B1752 (I.F) L.2.11
B1753 (I.F) L.2.12 B1754 (I.F) L.2.13 B1755 (I.F) L.2.14 B1756
(I.F) L.2.15 B1757 (I.F) L.2.16 B1758 (I.F) L.2.17 B1759 (I.F)
L.2.18 B1760 (I.F) L.2.19 B1761 (I.F) L.2.20 B1762 (I.F) L.2.21
B1763 (I.F) L.2.22 B1764 (I.F) L.2.23 B1765 (I.F) L.2.24 B1766
(I.F) L.2.25 B1767 (I.F) L.2.26 B1768 (I.F) L.2.27 B1769 (I.F)
L.2.28 B1770 (I.F) L.2.29 B1771 (I.F) L.2.30 B1772 (I.F) L.2.31
B1773 (I.F) L.2.32 B1774 (I.F) L.2.33 B1775 (I.F) L.3.1 B1776 (I.F)
L.3.2 B1777 (I.F) L.3.3 B1778 (I.F) L.3.4 B1779 (I.F) L.3.5 B1780
(I.F) L.3.6 B1781 (I.F) L.3.7 B1782 (I.F) L.3.8 B1783 (I.F) L.3.9
B1784 (I.F) L.3.10 B1785 (I.F) L.3.11 B1786 (I.F) L.3.12 B1787
(I.F) L.3.13 B1788 (I.F) L.3.14 B1789 (I.F) L.3.15 B1790 (I.F)
L.3.16 B1791 (I.F) L.3.17 B1792 (I.F) L.3.18 B1793 (I.F) L.3.19
B1794 (I.F) L.3.20 B1795 (I.F) L.3.21 B1796 (I.F) L.3.22 B1797
(I.F) L.3.23 B1798 (I.F) L.3.24 B1799 (I.F) L.3.25 B1800 (I.F)
L.3.26 B1801 (I.F) L.3.27 B1802 (I.F) L.3.28 B1803 (I.F) L.3.29
B1804 (I.F) L.3.30 B1805 (I.F) L.3.31 B1806 (I.F) L.3.32 B1807
(I.F) L.3.33 B1808 (I.F) L.3.34 B1809 (I.F) L.3.35 B1810 (I.F)
L.3.36 B1811 (I.F) L.3.37 B1812 (I.F) L.3.38 B1813 (I.F) L.3.39
B1814 (I.F) L.3.40 B1815 (I.F) L.3.41 B1816 (I.F) L.3.42 B1817
(I.F) L.3.43 B1818 (I.F) L.3.44 B1819 (I.F) L.3.45 B1820 (I.F)
L.3.46 B1821 (I.F) L.3.47 B1822 (I.F) L.3.48 B1823 (I.F) L.3.49
B1824 (I.F) L.3.50 B1825 (I.F) L.3.51 B1826 (I.F) L.3.52 B1827
(I.F) L.3.53 B1828 (I.F) L.3.54 B1829 (I.F) L.3.55 B1830 (I.F)
L.3.56 B1831 (I.F) L.3.57 B1832 (I.F) L.3.58 B1833 (I.F) L.3.59
B1834 (I.F) L.3.60 B1835 (I.F) L.3.61 B1836 (I.F) L.3.62 B1837
(I.F) L.3.63 B1838 (I.F) L.3.1 B1839 (I.F) L.3.2 B1840 (I.F) L.4.1
B1841 (I.F) L.4.2 B1842 (I.F) L.4.3 B1843 (I.F) L.4.4 B1844 (I.F)
L.4.5 B1845 (I.F) L.4.6 B1846 (I.F) L.4.7 B1847 (I.F) L.4.8 B1848
(I.F) L.4.9 B1849 (I.F) L.4.10 B1850 (I.F) L.4.11 B1851 (I.F)
L.4.12 B1852 (I.F) L.4.13 B1853 (I.F) L.4.14 B1854 (I.F) L.4.15
B1855 (I.F) L.4.16 B1856 (I.F) L.4.17 B1857 (I.F) L.4.18 B1858
(I.F) L.4.19 B1859 (I.F) L.4.20 B1860 (I.F) L.4.21 B1861 (I.F)
L.4.22 B1862 (I.F) L.4.23 B1863 (I.F) L.4.24 B1864 (I.F) L.4.25
B1865 (I.F) L.4.26 B1866 (I.F) L.4.27 B1867 (I.F) L.4.28 B1868
(I.F) L.4.29 B1869 (I.F) L.4.30 B1870 (I.F) L.4.31 B1871 (I.F)
L.4.32 B1872 (I.F) L.4.33 B1873 (I.F) L.5.1 B1874 (I.F) L.5.2 B1875
(I.F) L.5.3 B1876 (I.F) L.5.4 B1877 (I.F) L.5.5 B1878 (I.F) L.5.6
B1879 (I.F) L.5.7 B1880 (I.F) L.5.8 B1881 (I.F) L.5.9 B1882 (I.F)
L.5.10 B1883 (I.F) L.5.11 B1884 (I.F) L.5.12 B1885 (I.F) L.5.13
B1886 (I.F) L.5.14 B1887 (I.F) L.5.15 B1888 (I.F) L.5.16 B1889
(I.F) L.5.17 B1890 (I.F) L.5.18 B1891 (I.F) L.5.19
B1892 (I.F) L.5.20 B1893 (I.F) L.5.21 B1894 (I.F) L.5.22 B1895
(I.F) L.5.23 B1896 (I.F) L.5.24 B1897 (I.F) L.5.25 B1898 (I.F)
L.5.26 B1899 (I.F) L.5.27 B1900 (I.F) L.5.28 B1901 (I.F) L.5.29
B1902 (I.F) L.5.30 B1903 (I.F) L.5.31 B1904 (I.F) L.5.32 B1905
(I.F) L.5.33 B1906 (I.F) L.5.34 B1907 (I.F) L.5.35 B1908 (I.F)
L.5.36 B1909 (I.F) L.5.37 B1910 (I.F) L.5.38 B1911 (I.F) L.5.39
B1912 (I.F) L.5.40 B1913 (I.F) L.5.41 B1914 (I.F) L.5.42 B1915
(I.F) L.5.43 B1916 (I.F) L.5.44 B1917 (I.F) L.5.45 B1918 (I.F)
L.5.46 B1919 (I.F) L.5.47 B1920 (I.F) L.5.48 B1921 (I.F) L.5.49
B1922 (I.F) L.5.50 B1923 (I.F) L.5.51 B1924 (I.F) L.5.52 B1925
(I.F) L.5.53 B1926 (I.F) L.5.54 B1927 (I.F) L.5.55 B1928 (I.F)
L.5.56 B1929 (I.F) L.5.57 B1930 (I.F) L.5.58 B1931 (I.F) L.5.59
B1932 (I.F) L.5.60 B1933 (I.F) L.5.61 B1934 (I.F) L.5.62 B1935
(I.F) L.5.63 B1936 (I.F) L.5.64 B1937 (I.F) L.5.65 B1938 (I.F)
L.5.68 B1939 (I.F) L.5.67 B1940 (I.F) L.5.68 B1941 (I.F) L.5.69
B1942 (I.F) L.5.70 B1943 (I.F) L.5.71 B1944 (I.F) L.5.72 B1945
(I.F) L.5.73 B1946 (I.F) L.5.74 B1947 (I.F) L.5.75 B1948 (I.F)
L.5.76 B1949 (I.F) L.5.77 B1950 (I.F) L.5.78 B1951 (I.F) L.5.79
B1952 (I.F) L.5.80 B1953 (I.F) L.5.81 B1954 (I.F) L.5.82 B =
Mixture; I = compound I; II = compound II
TABLE-US-00008 TABLE 56 B I II B1975 (I.G) L.1.1 B1976 (I.G) L.1.2
B1977 (I.G) L.1.3 B1978 (I.G) L.1.4 B1979 (I.G) L.1.5 B1980 (I.G)
L.1.6 B1981 (I.G) L.1.7 B1982 (I.G) L.1.8 B1983 (I.G) L.1.9 B1984
(I.G) L.1.10 B1985 (I.G) L.1.11 B1986 (I.G) L.1.12 B1987 (I.G)
L.1.13 B1988 (I.G) L.1.14 B1989 (I.G) L.1.15 B1990 (I.G) L.1.16
B1991 (I.G) L.1.17 B1992 (I.G) L.1.18 B1993 (I.G) L.1.19 B1994
(I.G) L.1.20 B1995 (I.G) L.1.21 B1996 (I.G) L.1.22 B1997 (I.G)
L.1.23 B1998 (I.G) L.1.24 B1999 (I.G) L.1.25 B2000 (I.G) L.1.26
B2001 (I.G) L.1.27 B2002 (I.G) L.1.28 B2003 (I.G) L.1.29 B2004
(I.G) L.1.30 B2005 (I.G) L.1.31 B2006 (I.G) L.1.32 B2007 (I.G)
L.1.33 B2008 (I.G) L.1.34 B2009 (I.G) L.1.35 B2010 (I.G) L.1.36
B2011 (I.G) L.1.37 B2012 (I.G) L.1.38 B2013 (I.G) L.1.39 B2014
(I.G) L.1.40 B2015 (I.G) L.1.41 B2016 (I.G) L.1.42 B2017 (I.G)
L.1.43 B2018 (I.G) L.1.44 B2019 (I.G) L.1.45 B2020 (I.G) L.1.46
B2021 (I.G) L.1.47 B2022 (I.G) L.1.48 B2023 (I.G) L.1.49 B2024
(I.G) L.1.50 B2025 (I.G) L.1.51 B2026 (I.G) L.1.52 B2027 (I.G)
L.1.53 B2028 (I.G) L.1.54 B2029 (I.G) L.1.55 B2030 (I.G) L.1.56
B2031 (I.G) L.1.57 B2032 (I.G) L.1.58 B2033 (I.G) L.1.59 B2034
(I.G) L.1.60 B2035 (I.G) L.1.61 B2036 (I.G) L.1.62 B2037 (I.G)
L.1.63 B2038 (I.G) L.1.64 B2039 (I.G) L.1.65 B2040 (I.G) L.1.66
B2041 (I.G) L.1.67 B2042 (I.G) L.1.68 B2043 (I.G) L.1.69 B2044
(I.G) L.1.70 B2045 (LG) L.1.71 B2046 (I.G) L.1.72 B2047 (I.G)
L.1.73 B2048 (I.G) L.1.74 B2049 (I.G) L.1.75 B2050 (I.G) L.1.76
B2051 (I.G) L.1.77 B2052 (I.G) L.1.78 B2053 (I.G) L.1.79 B2054
(I.G) L.1.80 B2055 (I.G) L.1.81 B2056 (I.G) L.1.82 B2057 (I.G)
L.1.83 B2058 (I.G) L.1.84 B2059 (I.G) L.1.85 B2060 (I.G) L.1.86
B2061 (I.G) L.1.87 B2062 (I.G) L.1.88 B2063 (I.G) L.1.89 B2064
(I.G) L.1.90 B2065 (I.G) L.1.91 B2066 (I.G) L.1.92 B2067 (I.G)
L.1.93 B2068 (I.G) L.1.94 B2069 (I.G) L.1.95 B2070 (I.G) L.1.96
B2071 (I.G) L.2.1 B2072 (I.G) L.2.2 B2073 (I.G) L.2.3 B2074 (I.G)
L.2.4 B2075 (I.G) L.2.5 B2076 (I.G) L.2.6 B2077 (I.G) L.2.7 B2078
(I.G) L.2.8 B2079 (I.G) L.2.9 B2080 (I.G) L.2.10 B2081 (I.G) L.2.11
B2082 (I.G) L.2.12 B2083 (I.G) L.2.13 B2084 (I.G) L.2.14 B2085
(I.G) L.2.15 B2086 (I.G) L.2.16 B2087 (I.G) L.2.17 B2088 (I.G)
L.2.18 B2089 (I.G) L.2.19 B2090 (I.G) L.2.20 B2091 (I.G) L.2.21
B2092 (I.G) L.2.22 B2093 (I.G) L.2.23 B2094 (I.G) L.2.24 B2095
(I.G) L.2.25 B2096 (I.G) L.2.26 B2097 (I.G) L.2.27 B2098 (I.G)
L.2.28 B2099 (I.G) L.2.29 B2100 (I.G) L.2.30 B2101 (I.G) L.2.31
B2102 (I.G) L.2.32 B2103 (I.G) L.2.33 B2104 (I.G) L.3.1 B2105 (I.G)
L.3.2 B2106 (I.G) L.3.3 B2107 (I.G) L.3.4 B2108 (I.G) L.3.5 B2109
(I.G) L.3.6 B2110 (I.G) L.3.7 B2111 (I.G) L.3.8 B2112 (I.G) L.3.9
B2113 (I.G) L.3.10 B2114 (I.G) L.3.11 B2115 (I.G) L.3.12 B2116
(I.G) L.3.13 B2117 (I.G) L.3.14 B2118 (I.G) L.3.15 B2119 (I.G)
L.3.16 B2120 (I.G) L.3.17 B2121 (I.G) L.3.18 B2122 (I.G) L.3.19
B2123 (I.G) L.3.20 B2124 (I.G) L.3.21 B2125 (I.G) L.3.22 B2126
(I.G) L.3.23 B2127 (I.G) L.3.24 B2128 (I.G) L.3.25 B2129 (I.G)
L.3.26 B2130 (I.G) L.3.27 B2131 (I.G) L.3.28 B2132 (I.G) L.3.29
B2133 (I.G) L.3.30 B2134 (I.G) L.3.31 B2135 (I.G) L.3.32 B2136
(I.G) L.3.33 B2137 (I.G) L.3.34 B2138 (I.G) L.3.35 B2139 (I.G)
L.3.36 B2140 (I.G) L.3.37 B2141 (I.G) L.3.38 B2142 (I.G) L.3.39
B2143 (I.G) L.3.40 B2144 (I.G) L.3.41 B2145 (I.G) L.3.42 B2146
(I.G) L.3.43 B2147 (I.G) L.3.44 B2148 (I.G) L.3.45 B2149 (I.G)
L.3.46 B2150 (I.G) L.3.47 B2151 (I.G) L.3.48 B2152 (I.G) L.3.49
B2153 (LG) L.3.50 B2154 (I.G) L.3.51 B2155 (I.G) L.3.52 B2156 (I.G)
L.3.53 B2157 (I.G) L.3.54 B2158 (I.G) L.3.55 B2159 (I.G) L.3.56
B2160 (I.G) L.3.57 B2161 (I.G) L.3.58 B2162 (I.G) L.3.59 B2163
(I.G) L.3.60 B2164 (I.G) L.3.61 B2165 (I.G) L.3.62 B2166 (I.G)
L.3.63 B2167 (I.G) L.3.1 B2168 (I.G) L.3.2 B2169 (I.G) L.4.1 B2170
(I.G) L.4.2 B2171 (I.G) L.4.3 B2172 (I.G) L.4.4 B2173 (I.G) L.4.5
B2174 (I.G) L.4.6 B2175 (I.G) L.4.7 B2176 (I.G) L.4.8 B2177 (I.G)
L.4.9 B2178 (I.G) L.4.10 B2179 (I.G) L.4.11 B2180 (I.G) L.4.12
B2181 (I.G) L.4.13 B2182 (I.G) L.4.14 B2183 (I.G) L.4.15 B2184
(I.G) L.4.16 B2185 (I.G) L.4.17 B2186 (I.G) L.4.18 B2187 (I.G)
L.4.19 B2188 (I.G) L.4.20 B2189 (I.G) L.4.21 B2190 (I.G) L.4.22
B2191 (I.G) L.4.23 B2192 (I.G) L.4.24 B2193 (I.G) L.4.25 B2194
(I.G) L.4.26 B2195 (I.G) L.4.27 B2196 (I.G) L.4.28 B2197 (I.G)
L.4.29 B2198 (I.G) L.4.30 B2199 (I.G) L.4.31 B2200 (I.G) L.4.32
B2201 (I.G) L.4.33 B2202 (I.G) L.5.1 B2203 (I.G) L.5.2 B2204 (I.G)
L.5.3 B2205 (I.G) L.5.4 B2206 (I.G) L.5.5 B2207 (I.G) L.5.6 B2208
(I.G) L.5.7 B2209 (I.G) L.5.8 B2210 (I.G) L.5.9 B2211 (I.G) L.5.10
B2212 (I.G) L.5.11 B2213 (I.G) L.5.12 B2214 (I.G) L.5.13 B2215
(I.G) L.5.14 B2216 (I.G) L.5.15 B2217 (I.G) L.5.16 B2218 (I.G)
L.5.17 B2219 (I.G) L.5.18 B2220 (I.G) L.5.19
B2221 (I.G) L.5.20 B2222 (I.G) L.5.21 B2223 (I.G) L.5.22 B2224
(I.G) L.5.23 B2225 (I.G) L.5.24 B2226 (I.G) L.5.25 B2227 (I.G)
L.5.26 R2228 (I.G) L.5.27 B2229 (I.G) L.5.28 B2230 (I.G) L.5.29
B2231 (I.G) L.5.30 B2232 (I.G) L.5.31 B2233 (I.G) L.5.32 B2234
(I.G) L.5.33 B2235 (I.G) L.5.34 B2236 (I.G) L.5.35 B2237 (I.G)
L.5.36 B2238 (I.G) L.5.37 B2239 (I.G) L.5.38 B2240 (I.G) L.5.39
B2241 (I.G) L.5.40 B2242 (I.G) L.5.41 B2243 (I.G) L.5.42 B2244
(I.G) L.5.43 B2245 (I.G) L.5.44 B2246 (I.G) L.5.45 B2247 (I.G)
L.5.46 B2248 (I.G) L.5.47 B2249 (I.G) L.5.48 B2250 (I.G) L.5.49
B2251 (I.G) L.5.50 B2252 (I.G) L.5.51 B2253 (I.G) L.5.52 B2254
(I.G) L.5.53 B2255 (I.G) L.5.54 B2256 (I.G) L.5.55 B2257 (I.G)
L.5.56 B2258 (I.G) L.5.57 B2259 (I.G) L.5.58 B2260 (I.G) L.5.59
B2261 (I.G) L.5.60 B2262 (I.G) L.5.61 B2263 (I.G) L.5.62 B2264
(I.G) L.5.63 B2265 (I.G) L.5.64 B2266 (I.G) L.5.65 B2267 (I.G)
L.5.66 B2268 (I.G) L.5.67 B2269 (I.G) L.5.68 B2270 (I.G) L.5.69
B2271 (I.G) L.5.70 B2272 (I.G) L.5.71 B2273 (I.G) L.5.72 B2274
(I.G) L.5.73 B2275 (I.G) L.5.74 B2276 (I.G) L.5.75 B2277 (I.G)
L.5.76 B2278 (I.G) L.5.77 B2279 (I.G) L.5.78 B2280 (I.G) L.5.79
B2281 (I.G) L.5.80 B2282 (I.G) L.5.81 B2283 (I.G) L.5.82 B2284
(I.G) L.5.83 B2285 (I.G) L.5.84 B2286 (I.G) L.6.1 B2287 (I.G) L.6.2
B2288 (I.G) L.6.3 B2289 (I.G) L.6.4 B2290 (I.G) L.6.5 B2291 (I.G)
L.6.6 B2292 (I.G) L.6.7 B2293 (I.G) L.6.8 B2294 (I.G) L.6.9 B2295
(I.G) L.6.10 B2296 (I.G) L.6.11 B2297 (I.G) L.6.12 B2298 (I.G)
L.6.13 B2299 (I.G) L.6.14 B2300 (I.G) L.6.15 B2301 (I.G) L.6.16
B2302 (I.G) L.6.17 B2303 (I.G) L.6.18 B = Mixture; I = compound I;
II = compound II
TABLE-US-00009 TABLE 57 B I II B2304 (I.H) L.1.1 B2305 (I.H) L.1.2
B2306 (I.H) L.1.3 B2307 (I.H) L.1.4 B2308 (I.H) L.1.5 B2309 (I.H)
L.1.6 B2310 (I.H) L.1.7 B2311 (I.H) L.1.8 B2312 (I.H) L.1.9 B2313
(I.H) L.1.10 B2314 (I.H) L.1.11 B2315 (I.H) L.1.12 B2316 (I.H)
L.1.13 B2317 (I.H) L.1.14 B2318 (I.H) L.1.15 B2319 (I.H) L.1.16
B2320 (I.H) L.1.17 B2321 (I.H) L.1.18 B2322 (I.H) L.1.19 B2323
(I.H) L.1.20 B2324 (I.H) L.1.21 B2325 (I.H) L.1.22 B2326 (I.H)
L.1.23 B2327 (I.H) L.1.24 B2328 (I.H) L.1.25 B2329 (I.H) L.1.26
B2330 (I.H) L.1.27 B2331 (I.H) L.1.28 B2332 (I.H) L.1.29 B2333
(I.H) L.1.30 B2334 (I.H) L.1.31 B2335 (I.H) L.1.32 B2336 (I.H)
L.1.33 B2337 (I.H) L.1.34 B2338 (I.H) L.1.35 B2339 (I.H) L.1.36
B2340 (I.H) L.1.37 B2341 (I.H) L.1.38 B2342 (I.H) L.1.39 B2343
(I.H) L.1.40 B2344 (I.H) L.1.41 B2345 (I.H) L.1.42 B2346 (I.H)
L.1.43 B2347 (I.H) L.1.44 B2348 (I.H) L.1.45 B2349 (I.H) L.1.46
B2350 (I.H) L.1.47 B2351 (I.H) L.1.48 B2352 (I.H) L.1.49 B2353
(I.H) L.1.50 B2354 (I.H) L.1.51 B2355 (I.H) L.1.52 B2356 (I.H)
L.1.53 B2357 (I.H) L.1.54 B2358 (I.H) L.1.55 B2359 (I.H) L.1.56
B2360 (I.H) L.1.57 B2361 (I.H) L.1.58 B2362 (I.H) L.1.59 B2363
(I.H) L.1.60 B2364 (I.H) L.1.61 B2365 (I.H) L.1.62 B2366 (I.H)
L.1.63 B2367 (I.H) L.1.64 B2368 (I.H) L.1.65 B2369 (I.H) L.1.66
B2370 (I.H) L.1.67 B2371 (I.H) L.1.68 B2372 (I.H) L.1.69 B2373
(I.H) L.1.70 B2374 (I.H) L.1.71 B2375 (I.H) L.1.72 B2376 (I.H)
L.1.73 B2377 (I.H) L.1.74 B2378 (I.H) L.1.75 B2379 (I.H) L.1.76
B2380 (I.H) L.1.77 B2381 (I.H) L.1.78 B2382 (I.H) L.1.79 B2383
(I.H) L.1.80 B2384 (I.H) L.1.81 B2385 (I.H) L.1.82 B2386 (I.H)
L.1.83 B2387 (I.H) L.1.84 B2388 (I.H) L.1.85 B2389 (I.H) L.1.86
B2390 (I.H) L.1.87 B2391 (I.H) L.1.88 B2392 (I.H) L.1.89 B2393
(I.H) L.1.90 B2394 (I.H) L.1.91 B2395 (I.H) L.1.92 B2396 (I.H)
L.1.93 B2397 (I.H) L.1.94 B2398 (I.H) L.1.95 B2399 (I.H) L.1.96
B2400 (I.H) L.2.1 B2401 (I.H) L.2.2 B2402 (I.H) L.2.3 B2403 (I.H)
L.2.4 B2404 (I.H) L.2.5 B2405 (I.H) L.2.6 B2406 (I.H) L.2.7 B2407
(I.H) L.2.8 B2408 (I.H) L.2.9 B2409 (I.H) L.2.10 B2410 (I.H) L.2.11
B2411 (I.H) L.2.12 B2412 (I.H) L.2.13 B2413 (I.H) L.2.14 B2414
(I.H) L.2.15 B2415 (I.H) L.2.16 B2416 (I.H) L.2.17 B2417 (I.H)
L.2.18 B2418 (I.H) L.2.19 B2419 (I.H) L.2.20 B2420 (I.H) L.2.21
B2421 (I.H) L.2.22 B2422 (I.H) L.2.23 B2423 (I.H) L.2.24 B2424
(I.H) L.2.25 B2425 (I.H) L.2.26 B2426 (I.H) L.2.27 B2427 (I.H)
L.2.28 B2428 (I.H) L.2.29 B2429 (I.H) L.2.30 B2430 (I.H) L.2.31
B2431 (I.H) L.2.32 B2432 (I.H) L.2.33 B2433 (I.H) L.3.1 B2434 (I.H)
L.3.2 B2435 (I.H) L.3.3 B2436 (I.H) L.3.4 B2437 (I.H) L.3.5 B2438
(I.H) L.3.6 B2439 (I.H) L.3.7 B2440 (I.H) L.3.8 B2441 (I.H) L.3.9
B2442 (I.H) L.3.10 B2443 (I.H) L.3.11 B2444 (I.H) L.3.12 B2445
(I.H) L.3.13 B2446 (I.H) L.3.14 B2447 (I.H) L.3.15 B2448 (I.H)
L.3.16 B2449 (I.H) L.3.17 B2450 (I.H) L.3.18 B2451 (I.H) L.3.19
B2452 (I.H) L.3.20 B2453 (I.H) L.3.21 B2454 (I.H) L.3.22 B2455
(I.H) L.3.23 B2456 (I.H) L.3.24 B2457 (I.H) L.3.25 B2458 (I.H)
L.3.26 B2459 (I.H) L.3.27 B2460 (I.H) L.3.28 B2461 (I.H) L.3.29
B2462 (I.H) L.3.30 B2463 (I.H) L.3.31 B2464 (I.H) L.3.32 B2465
(I.H) L.3.33 B2466 (I.H) L.3.34 B2467 (I.H) L.3.35 B2468 (I.H)
L.3.36 B2469 (I.H) L.3.37 B2470 (I.H) L.3.38 B2471 (I.H) L.3.39
B2472 (I.H) L.3.40 B2473 (I.H) L.3.41 B2474 (I.H) L.3.42 B2475
(I.H) L.3.43 B2476 (I.H) L.3.44 B2477 (I.H) L.3.45 B2478 (I.H)
L.3.46 B2479 (I.H) L.3.47 B2480 (I.H) L.3.48 B2481 (I.H) L.3.49
B2482 (I.H) L.3.50 B2483 (I.H) L.3.51 B2484 (I.H) L.3.52 B2485
(I.H) L.3.53 B2486 (I.H) L.3.54 B2487 (I.H) L.3.55 B2488 (I.H)
L.3.56 B2489 (I.H) L.3.57 B2490 (I.H) L.3.58 B2491 (I.H) L.3.59
B2492 (I.H) L.3.60 B2493 (I.H) L.3.61 B2494 (I.H) L.3.62 B2495
(I.H) L.3.63 B2496 (I.H) L.3.1 B2497 (I.H) L.3.2 B2498 (I.H) L.4.1
B2499 (I.H) L.4.2 B2500 (I.H) L.4.3 B2501 (I.H) L.4.4 B2502 (I.H)
L.4.5 B2503 (I.H) L.4.6 B2504 (I.H) L.4.7 B2505 (I.H) L.4.8 B2506
(I.H) L.4.9 B2507 (I.H) L.4.10 B2508 (I.H) L.4.11 B2509 (I.H)
L.4.12 B2510 (I.H) L.4.13 B2511 (I.H) L.4.14 B2512 (I.H) L.4.15
B2513 (I.H) L.4.16 B2514 (I.H) L.4.17 B2515 (I.H) L.4.18 B2516
(I.H) L.4.19 B2517 (I.H) L.4.20 B2518 (I.H) L.4.21 B2519 (I.H)
L.4.22 B2520 (I.H) L.4.23 B2521 (I.H) L.4.24 B2522 (I.H) L.4.25
B2523 (I.H) L.4.26 B2524 (I.H) L.4.27 B2525 (I.H) L.4.28 B2526
(I.H) L.4.29 B2527 (I.H) L.4.30 B2528 (I.H) L.4.31 B2529 (I.H)
L.4.32 B2530 (I.H) L.4.33 B2531 (I.H) L.5.1 B2532 (I.H) L.5.2 B2533
(I.H) L.5.3 B2534 (I.H) L.5.4 B2535 (I.H) L.5.5 B2536 (I.H) L.5.6
B2537 (I.H) L.5.7 B2538 (I.H) L.5.8 B2539 (I.H) L.5.9 B2540 (I.H)
L.5.10 B2541 (I.H) L.5.11 B2542 (I.H) L.5.12 B2543 (I.H) L.5.13
B2544 (I.H) L.5.14 B2545 (I.H) L.5.15 B2546 (I.H) L.5.16 B2547
(I.H) L.5.17 B2548 (I.H) L.5.18 B2549 (I.H) L.5.19
B2550 (I.H) L.5.20 B2551 (I.H) L.5.21 B2552 (I.H) L.5.22 B2553
(I.H) L.5.23 B2554 (I.H) L.5.24 B2555 (I.H) L.5.25 B2556 (I.H)
L.5.26 B2557 (I.H) L.5.27 B2558 (I.H) L.5.28 B2559 (I.H) L.5.29
B2560 (I.H) L.5.30 B2561 (I.H) L.5.31 B2562 (I.H) L.5.32 B2563
(I.H) L.5.33 B2564 (I.H) L.5.34 B2565 (I.H) L.5.35 B2566 (I.H)
L.5.36 B2567 (I.H) L.5.37 B2568 (I.H) L.5.38 B2569 (I.H) L.5.39
B2570 (I.H) L.5.40 B2571 (I.H) L.5.41 B2572 (I.H) L.5.42 B2573
(I.H) L.5.43 B2574 (I.H) L.5.44 B2575 (I.H) L.5.45 B2576 (I.H)
L.5.46 B2577 (I.H) L.5.47 B2578 (I.H) L.5.48 B2579 (I.H) L.5.49
B2580 (I.H) L.5.50 B2581 (I.H) L.5.51 B2582 (I.H) L.5.52 B2583
(I.H) L.5.53 B2584 (I.H) L.5.54 B2585 (I.H) L.5.55 B2586 (I.H)
L.5.56 B2587 (I.H) L.5.57 B2588 (I.H) L.5.58 B2589 (I.H) L.5.59
B2590 (I.H) L.5.60 B2591 (I.H) L.5.61 B2592 (I.H) L.5.62 B2593
(I.H) L.5.63 B2594 (I.H) L.5.64 B2595 (I.H) L.5.65 B2596 (I.H)
L.5.66 B2597 (I.H) L.5.67 B2598 (I.H) L.5.68 B2599 (I.H) L.5.69
B2600 (I.H) L.5.70 B2601 (I.H) L.5.71 B2602 (I.H) L.5.72 B2603
(I.H) L.5.73 B2604 (I.H) L.5.74 B2605 (I.H) L.5.75 B2606 (I.H)
L.5.76 B2607 (I.H) L.5.77 B2608 (I.H) L.5.78 B2609 (I.H) L.5.79
B2610 (I.H) L.5.80 B2611 (I.H) L.5.81 B2612 (I.H) L.5.82 B2613
(I.H) L.5.83 B2614 (I.H) L.5.84 B2615 (I.H) L.6.1 B2616 (I.H) L.6.2
B2617 (I.H) L.6.3 B2618 (I.H) L.6.4 B2619 (I.H) L.6.5 B2620 (I.H)
L.6.6 B2621 (I.H) L.6.7 B2622 (I.H) L.6.8 B2623 (I.H) L.6.9 B2624
(I.H) L.6.10 B2625 (I.H) L.6.11 B2626 (I.H) L.6.12 B2627 (I.H)
L.6.13 B2628 (I.H) L.6.14 B2629 (I.H) L.6.15 B2630 (I.H) L.6.16
B2631 (I.H) L.6.17 B2632 (I.H) L.6.18 B = Mixture; I = compound I;
II = compound II
TABLE-US-00010 TABLE 58 B I II B2633 (I.J) L.1.1 B2634 (I.J) L.1.2
B2635 (I.J) L.1.3 B2636 (I.J) L.1.4 B2637 (I.J) L.1.5 B2638 (I.J)
L.1.6 B2639 (I.J) L.1.7 B2640 (I.J) L.1.8 B2641 (I.J) L.1.9 B2642
(I.J) L.1.10 B2643 (I.J) L.1.11 B2644 (I.J) L.1.12 B2645 (I.J)
L.1.13 B2646 (I.J) L.1.14 B2647 (I.J) L.1.15 B2648 (I.J) L.1.16
B2649 (I.J) L.1.17 B2650 (I.J) L.1.18 B2651 (I.J) L.1.19 B2652
(I.J) L.1.20 B2653 (I.J) L.1.21 B2654 (I.J) L.1.22 B2655 (I.J)
L.1.23 B2656 (I.J) L.1.24 B2657 (I.J) L.1.25 B2658 (I.J) L.1.26
B2659 (I.J) L.1.27 B2660 (I.J) L.1.28 B2661 (I.J) L.1.29 B2662
(I.J) L.1.30 B2663 (I.J) L.1.31 B2664 (I.J) L.1.32 B2665 (I.J)
L.1.33 B2666 (I.J) L.1.34 B2667 (I.J) L.1.35 B2668 (I.J) L.1.36
B2669 (I.J) L.1.37 B2670 (I.J) L.1.38 B2671 (I.J) L.1.39 B2672
(I.J) L.1.40 B2673 (I.J) L.1.41 B2674 (I.J) L.1.42 B2675 (I.J)
L.1.43 B2676 (I.J) L.1.44 B2677 (I.J) L.1.45 B2678 (I.J) L.1.46
B2679 (I.J) L.1.47 B2680 (I.J) L.1.48 B2681 (I.J) L.1.49 B2682
(I.J) L.1.50 B2683 (I.J) L.1.51 B2684 (I.J) L.1.52 B2685 (I.J)
L.1.53 B2686 (I.J) L.1.54 B2687 (I.J) L.1.55 B2688 (I.J) L.1.56
B2689 (I.J) L.1.57 B2690 (I.J) L.1.58 B2691 (I.J) L.1.59 B2692
(I.J) L.1.60 B2693 (I.J) L.1.61 B2694 (I.J) L.1.62 B2695 (I.J)
L.1.63 B2696 (I.J) L.1.64 B2697 (I.J) L.1.65 B3698 (I.J) L.1.66
B2699 (I.J) L.1.67 B2700 (I.J) L.1.68 B2701 (I.J) L.1.69 B2702
(I.J) L.1.70 B2703 (I.J) L.1.71 B2704 (I.J) L.1.72 B2705 (I.J)
L.1.73 B2706 (I.J) L.1.74 B2707 (I.J) L.1.75 B2708 (I.J) L.1.76
B2709 (I.J) L.1.77 B2710 (I.J) L.1.78 B2711 (I.J) L.1.79 B2712
(I.J) L.1.80 B2713 (I.J) L.1.81 B2714 (I.J) L.1.82 B2715 (I.J)
L.1.83 B2716 (I.J) L.1.84 B2717 (I.J) L.1.85 B2718 (I.J) L.1.86
B2719 (I.J) L.1.87 B2720 (I.J) L.1.88 B2721 (I.J) L.1.89 B2722
(I.J) L.1.90 B2723 (I.J) L.1.91 B2724 (I.J) L.1.92 B2725 (I.J)
L.1.93 B2726 (I.J) L.1.94 B2727 (I.J) L.1.95 B2728 (I.J) L.1.96
B2729 (I.J) L.2.1 B2730 (I.J) L.2.2 B2731 (I.J) L.2.3 B2732 (I.J)
L.2.4 B2733 (I.J) L.2.5 B2734 (I.J) L.2.6 B2735 (I.J) L.2.7 B2736
(I.J) L.2.8 B2737 (I.J) L.2.9 B2738 (I.J) L.2.10 B2739 (I.J) L.2.11
B2740 (I.J) L.2.12 B2741 (I.J) L.2.13 B2742 (I.J) L.2.14 B2743
(I.J) L.2.15 B2744 (I.J) L.2.16 B2745 (I.J) L.2.17 B2746 (I.J)
L.2.18 B2747 (I.J) L.2.19 B2748 (I.J) L.2.20 B2749 (I.J) L.2.21
B2750 (I.J) L.2.22 B2751 (I.J) L.2.23 B2752 (I.J) L.2.24 B2753
(I.J) L.2.25 B2754 (I.J) L.2.26 B2755 (I.J) L.2.27 B2756 (I.J)
L.2.28 B2757 (I.J) L.2.29 B2758 (I.J) L.2.30 B2759 (I.J) L.2.31
B2760 (I.J) L.2.32 B2761 (I.J) L.2.33 B2762 (I.J) L.3.1 B2763 (I.J)
L.3.2 B2764 (I.J) L.3.3 B2765 (I.J) L.3.4 B2766 (I.J) L.3.5 B2767
(I.J) L.3.6 B2768 (I.J) L.3.7 B2769 (I.J) L.3.8 B2770 (I.J) L.3.9
B2771 (I.J) L.3.10 B2772 (I.J) L.3.11 B2773 (I.J) L.3.12 B2774
(I.J) L.3.13 B2775 (I.J) L.3.14 B2776 (I.J) L.3.15 B2777 (I.J)
L.3.16 B2778 (I.J) L.3.17 B2779 (I.J) L.3.18 B2780 (I.J) L.3.19
B2781 (I.J) L.3.20 B2782 (I.J) L.3.21 B2783 (I.J) L.3.22 B2784
(I.J) L.3.23 B2785 (I.J) L.3.24 B2786 (I.J) L.3.25 B2787 (I.J)
L.3.26 B2788 (I.J) L.3.27 B2789 (I.J) L.3.28 B2790 (I.J) L.3.29
B2791 (I.J) L.3.30 B2792 (I.J) L.3.31 B2793 (I.J) L.3.32 B2794
(I.J) L.3.33 B2795 (I.J) L.3.34 B2796 (I.J) L.3.35 B2797 (I.J)
L.3.36 B2798 (I.J) L.3.37 B2799 (I.J) L.3.38 B2800 (I.J) L.3.39
B2801 (I.J) L.3.40 B2802 (I.J) L.3.41 B2803 (I.J) L.3.42 B2804
(I.J) L.3.43 B2805 (I.J) L.3.44 B2806 (I.J) L.3.45 B2807 (I.J)
L.3.46 B2808 (I.J) L.3.47 B2809 (I.J) L.3.48 B2810 (I.J) L.3.49
B2811 (I.J) L.3.50 B2812 (I.J) L.3.51 B2813 (I.J) L.3.52 B2814
(I.J) L.3.53 B2815 (I.J) L.3.54 B2816 (I.J) L.3.55 B2817 (I.J)
L.3.56 B2818 (I.J) L.3.57 B2819 (I.J) L.3.58 B2820 (I.J) L.3.59
B2821 (I.J) L.3.60 B2822 (I.J) L.3.61 B2823 (I.J) L.3.62 B2824
(I.J) L.3.63 B2825 (I.J) L.3.1 B2826 (I.J) L.3.2 B2827 (I.J) L.4.1
B2828 (I.J) L.4.2 B2829 (I.J) L.4.3 B2830 (I.J) L.4.4 B2831 (I.J)
L.4.5 B2832 (I.J) L.4.6 B2833 (I.J) L.4.7 B2834 (I.J) L.4.8 B2835
(I.J) L.4.9 B2836 (I.J) L.4.10 B2837 (I.J) L.4.11 B2838 (I.J)
L.4.12 B2839 (I.J) L.4.13 B2840 (I.J) L.4.14 B2841 (I.J) L.4.15
B2842 (I.J) L.4.16 B2843 (I.J) L.4.17 B2844 (I.J) L.4.18 B2845
(I.J) L.4.19 B2846 (I.J) L.4.20 B2847 (I.J) L.4.21 B2848 (I.J)
L.4.22 B2849 (I.J) L.4.23 B2850 (I.J) L.4.24 B2851 (I.J) L.4.25
B2852 (I.J) L.4.26 B2853 (I.J) L.4.27 B2854 (I.J) L.4.28 B2855
(I.J) L.4.29 B2856 (I.J) L.4.30 B2857 (I.J) L.4.31 B2858 (I.J)
L.4.32 B2859 (I.J) L.4.33 B2860 (I.J) L.5.1 B2861 (I.J) L.5.2 B2862
(I.J) L.5.3 B2863 (I.J) L.5.4 B2864 (I.J) L.5.5 B2865 (I.J) L.5.6
B2866 (I.J) L.5.7 B2867 (I.J) L.5.8 B2868 (I.J) L.5.9 B2869 (I.J)
L.5.10 B2870 (I.J) L.5.11 B2871 (I.J) L.5.12 B2872 (I.J) L.5.13
B2873 (I.J) L.5.14 B2874 (I.J) L.5.15 B2875 (I.J) L.5.16 B2876
(I.J) L.5.17 B2877 (I.J) L.5.18 B2878 (I.J) L.5.19
B2879 (I.J) L.5.20 B2880 (I.J) L.5.21 B2881 (I.J) L.5.22 B2882
(I.J) L.5.23 B2883 (I.J) L.5.24 B2884 (I.J) L.5.25 B2885 (I.J)
L.5.26 B2886 (I.J) L.5.27 B2887 (I.J) L.5.28 B2888 (I.J) L.5.29
B2889 (I.J) L.5.30 B2890 (I.J) L.5.31 B2891 (I.J) L.5.32 B2892
(I.J) L.5.33 B2893 (I.J) L.5.34 B2894 (I.J) L.5.35 B2895 (I.J)
L.5.36 B2896 (I.J) L.5.37 B2897 (I.J) L.5.38 B2898 (I.J) L.5.39
B2899 (I.J) L.5.40 B2900 (I.J) L.5.41 B2901 (I.J) L.5.42 B2902
(I.J) L.5.43 B2903 (I.J) L.5.44 B2904 (I.J) L.5.45 B2905 (I.J)
L.5.46 B2906 (I.J) L.5.47 B2907 (I.J) L.5.48 B2908 (I.J) L.5.49
B2909 (I.J) L.5.50 B2910 (I.J) L.5.51 B2911 (I.J) L.5.52 B2912
(I.J) L.5.53 B2913 (I.J) L.5.54 B2914 (I.J) L.5.55 B2915 (I.J)
L.5.56 B2916 (I.J) L.5.57 B2917 (I.J) L.5.58 B2918 (I.J) L.5.59
B2919 (I.J) L.5.60 B2920 (I.J) L.5.61 B2921 (I.J) L.5.62 B2922
(I.J) L.5.63 B2923 (I.J) L.5.64 B2924 (I.J) L.5.65 B2925 (I.J)
L.5.66 B2926 (I.J) L.5.67 B2927 (I.J) L.5.68 B2928 (I.J) L.5.69
B2929 (I.J) L.5.70 B2930 (I.J) L.5.71 B2931 (I.J) L.5.72 B2932
(I.J) L.5.73 B2933 (I.J) L.5.74 B2934 (I.J) L.5.75 B2935 (I.J)
L.5.76 B2936 (I.J) L.5.77 B2937 (I.J) L.5.78 B2938 (I.J) L.5.79
B2939 (I.J) L.5.80 B2940 (I.J) L.5.81 B2941 (I.J) L.5.82 B2942
(I.J) L.5.83 B2943 (I.J) L.5.84 B2944 (I.J) L.6.1 B2945 (I.J) L.6.2
B2946 (I.J) L.6.3 B2947 (I.J) L.6.4 B2948 (I.J) L.6.5 B2949 (I.J)
L.6.6 B2950 (I.J) L.6.7 B2951 (I.J) L.6.8 B2952 (I.J) L.6.9 B2953
(I.J) L.6.10 B2954 (I.J) L.6.11 B2955 (I.J) L.6.12 B2956 (I.J)
L.6.13 B2957 (I.J) L.6.14 B2958 (I.J) L.6.15 B2959 (I.J) L.6.16
B2960 (I.J) L.6.17 B2961 (I.J) L.6.18 B = Mixture; I = compound I;
II = compound II
TABLE-US-00011 TABLE 59 B I II B2962 (I.K) L.1.1 B2963 (I.K) L.1.2
B2964 (I.K) L.1.3 B2965 (I.K) L.1.4 B2966 (I.K) L.1.5 B2967 (I.K)
L.1.6 B2968 (I.K) L.1.7 B2969 (I.K) L.1.8 B2970 (I.K) L.1.9 B2971
(I.K) L.1.10 B2972 (I.K) L.1.11 B2973 (I.K) L.1.12 B2974 (I.K)
L.1.13 B2975 (I.K) L.1.14 B2976 (I.K) L.1.15 B2977 (I.K) L.1.16
B2978 (I.K) L.1.17 B2979 (I.K) L.1.18 B2980 (I.K) L.1.19 B2981
(I.K) L.1.20 B2982 (I.K) L.1.21 B2983 (I.K) L.1.22 B2984 (I.K)
L.1.23 B2985 (I.K) L.1.24 B2986 (I.K) L.1.25 B2987 (I.K) L.1.26
B2988 (I.K) L.1.27 B2989 (I.K) L.1.28 R2990 (I.K) L.1.29 B2991
(I.K) L.1.30 B2992 (I.K) L.1.31 B2993 (I.K) L.1.32 B2994 (I.K)
L.1.33 B2995 (I.K) L.1.34 B2996 (I.K) L.1.35 B2997 (I.K) L.1.36
B2998 (I.K) L.1.37 B2999 (I.K) L.1.38 B3000 (I.K) L.1.39 B3001
(I.K) L.1.40 B3002 (I.K) L.1.41 B3003 (I.K) L.1.42 B3004 (I.K)
L.1.43 B3005 (I.K) L.1.44 B3006 (I.K) L.1.45 B3007 (I.K) L.1.46
B3008 (I.K) L.1.47 B3009 (I.K) L.1.48 B3010 (I.K) L.1.49 B3011
(I.K) L.1.50 B3012 (I.K) L.1.51 B3013 (I.K) L.1.52 B3014 (I.K)
L.1.53 B3015 (I.K) L.1.54 B3016 (I.K) L.1.55 B3017 (I.K) L.1.56
B3018 (I.K) L.1.57 B3019 (I.K) L.1.58 B3020 (I.K) L.1.59 B3021
(I.K) L.1.60 B3022 (I.K) L.1.61 B3023 (I.K) L.1.62 B3024 (I.K)
L.1.63 B3025 (I.K) L.1.64 B3026 (I.K) L.1.65 B3027 (I.K) L.1.66
B3028 (I.K) L.1.67 B3029 (I.K) L.1.68 B3030 (I.K) L.1.69 B3031
(I.K) L.1.70 B3032 (I.K) L.1.71 B3033 (I.K) L.1.72 B3034 (I.K)
L.1.73 B3035 (I.K) L.1.74 B3036 (I.K) L.1.75 B3037 (I.K) L.1.76
B3038 (I.K) L.1.77 B3039 (I.K) L.1.78 B3040 (I.K) L.1.79 B3041
(I.K) L.1.80 B3042 (I.K) L.1.81 B3043 (I.K) L.1.82 B3044 (I.K)
L.1.83 B3045 (I.K) L.1.84 B3046 (I.K) L.1.85 B3047 (I.K) L.1.86
B3048 (I.K) L.1.87 B3049 (I.K) L.1.88 B3050 (I.K) L.1.89 B3051
(I.K) L.1.90 B3052 (I.K) L.1.91 B3053 (I.K) L.1.92 B3054 (I.K)
L.1.93 B3055 (I.K) L.1.94 B3056 (I.K) L.1.95 B3057 (I.K) L.1.96
B3058 (I.K) L.2.1 B3059 (I.K) L.2.2 B3060 (I.K) L.2.3 B3061 (I.K)
L.2.4 B3062 (I.K) L.2.5 B3063 (I.K) L.2.6 B3064 (I.K) L.2.7 B3065
(I.K) L.2.8 B3066 (I.K) L.2.9 B3067 (I.K) L.2.10 B3068 (I.K) L.2.11
B3069 (I.K) L.2.12 B3070 (I.K) L.2.13 B3071 (I.K) L.2.14 B3072
(I.K) L.2.15 B3073 (I.K) L.2.16 B3074 (I.K) L.2.17 B3075 (I.K)
L.2.18 B3076 (I.K) L.2.19 B3077 (I.K) L.2.20 B3078 (I.K) L.2.21
B3079 (I.K) L.2.22 B3080 (I.K) L.2.23 B3081 (I.K) L.2.24 B3082
(I.K) L.2.25 B3083 (I.K) L.2.26 B3084 (I.K) L.2.27 B3085 (I.K)
L.2.28 B3086 (I.K) L.2.29 B3087 (I.K) L.2.30 B3088 (I.K) L.2.31
B3089 (I.K) L.2.32 B3090 (I.K) L.2.33 B3091 (I.K) L.3.1 B3092 (I.K)
L.3.2 B3093 (I.K) L.3.3 B3094 (I.K) L.3.4 B3095 (I.K) L.3.5 B3096
(I.K) L.3.6 B3097 (I.K) L.3.7 B3098 (I.K) L.3.8 B3099 (I.K) L.3.9
B3100 (I.K) L.3.10 B3101 (I.K) L.3.11 B3102 (I.K) L.3.12 B3103
(I.K) L.3.13 B3104 (I.K) L.3.14 B3105 (I.K) L.3.15 B3106 (I.K)
L.3.16 B3107 (I.K) L.3.17 B3108 (I.K) L.3.18 B3109 (I.K) L.3.19
B3110 (I.K) L.3.20 B3111 (I.K) L.3.21 B3112 (I.K) L.3.22 B3113
(I.K) L.3.23 B3114 (I.K) L.3.24 B3115 (I.K) L.3.25 B3116 (I.K)
L.3.26 B3117 (I.K) L.3.27 B3118 (I.K) L.3.28 B3119 (I.K) L.3.29
B3120 (I.K) L.3.30 B3121 (I.K) L.3.31 B3122 (I.K) L.3.32 B3123
(I.K) L.3.33 B3124 (I.K) L.3.34 B3125 (I.K) L.3.35 B3126 (I.K)
L.3.36 B3127 (I.K) L.3.37 B3128 (I.K) L.3.38 B3129 (I.K) L.3.39
B3130 (I.K) L.3.40 B3131 (I.K) L.3.41 B3132 (I.K) L.3.42 B3133
(I.K) L.3.43 B3134 (I.K) L.3.44 B3135 (I.K) L.3.45 B3136 (I.K)
L.3.46 B3137 (I.K) L.3.47 B3138 (I.K) L.3.48 B3139 (I.K) L.3.49
B3140 (I.K) L.3.50 B3141 (I.K) L.3.51 B3142 (I.K) L.3.52 B3143
(I.K) L.3.53 B3144 (I.K) L.3.54 B3145 (I.K) L.3.55 B3146 (I.K)
L.3.56 B3147 (I.K) L.3.57 B3148 (I.K) L.3.58 B3149 (I.K) L.3.59
B3150 (I.K) L.3.60 B3151 (I.K) L.3.61 B3152 (I.K) L.3.62 B3153
(I.K) L.3.63 B3154 (I.K) L.3.1 B3155 (I.K) L.3.2 B3156 (I.K) L.4.1
B3157 (I.K) L.4.2 B3158 (I.K) L.4.3 B3159 (I.K) L.4.4 B3160 (I.K)
L.4.5 B3161 (I.K) L.4.6 B3162 (I.K) L.4.7 B3163 (I.K) L.4.8 B3164
(I.K) L.4.9 B3165 (I.K) L.4.10 B3166 (I.K) L.4.11 B3167 (I.K)
L.4.12 B3168 (I.K) L.4.13 B3169 (I.K) L.4.14 B3170 (I.K) L.4.15
B3171 (I.K) L.4.16 B3172 (I.K) L.4.17 B3173 (I.K) L.4.18 B3174
(I.K) L.4.19 B3175 (I.K) L.4.20 B3176 (I.K) L.4.21 B3177 (I.K)
L.4.22 B3178 (I.K) L.4.23 B3179 (I.K) L.4.24 B3180 (I.K) L.4.25
B3181 (I.K) L.4.26 B3182 (I.K) L.4.27 B3183 (I.K) L.4.28 B3184
(I.K) L.4.29 B3185 (I.K) L.4.30 B3186 (I.K) L.4.31 B3187 (I.K)
L.4.32 B3188 (I.K) L.4.33 B3189 (I.K) L.5.1 B3190 (I.K) L.5.2 B3191
(I.K) L.5.3 B3192 (I.K) L.5.4 B3193 (I.K) L.5.5 B3194 (I.K) L.5.6
B3195 (I.K) L.5.7 B3196 (I.K) L.5.8 B3197 (I.K) L.5.9 B3198 (I.K)
L.5.10 B3199 (I.K) L.5.11 B3200 (I.K) L.5.12 B3201 (I.K) L.5.13
B3202 (I.K) L.5.14 B3203 (I.K) L.5.15 B3204 (I.K) L.5.16 B3205
(I.K) L.5.17 B3206 (I.K) L.5.18 B3207 (I.K) L.5.19
B3208 (I.K) L.5.20 B3209 (I.K) L.5.21 B3210 (I.K) L.5.22 B3211
(I.K) L.5.23 B3212 (I.K) L.5.24 B3213 (I.K) L.5.25 B3214 (I.K)
L.5.26 B3215 (I.K) L.5.27 B3216 (I.K) L.5.28 B3217 (I.K) L.5.29
B3218 (I.K) L.5.30 B3219 (I.K) L.5.31 B3220 (I.K) L.5.32 B3221
(I.K) L.5.33 B3222 (I.K) L.5.34 B3223 (I.K) L.5.35 B3224 (I.K)
L.5.36 B3225 (I.K) L.5.37 B3226 (I.K) L.5.38 B3227 (I.K) L.5.39
B3228 (I.K) L.5.40 B3229 (I.K) L.5.41 B3230 (I.K) L.5.42 B3231
(I.K) L.5.43 B3232 (I.K) L.5.44 B3233 (I.K) L.5.45 B3234 (I.K)
L.5.46 B3235 (I.K) L.5.47 B3236 (I.K) L.5.48 B3237 (I.K) L.5.49
B3238 (I.K) L.5.50 B3239 (I.K) L.5.51 B3240 (I.K) L.5.52 B3241
(I.K) L.5.53 B3242 (I.K) L.5.54 B3243 (I.K) L.5.55 B3244 (I.K)
L.5.56 B3245 (I.K) L.5.57 B3246 (I.K) L.5.58 B3247 (I.K) L.5.59
B3248 (I.K) L.5.60 B3249 (I.K) L.5.61 B3250 (I.K) L.5.62 B3251
(I.K) L.5.63 B3252 (I.K) L.5.64 B3253 (I.K) L.5.65 B3254 (I.K)
L.5.66 B3255 (I.K) L.5.67 B3256 (I.K) L.5.68 B3257 (I.K) L.5.69
B3258 (I.K) L.5.70 B3259 (I.K) L.5.71 B3260 (I.K) L.5.72 B3261
(I.K) L.5.73 B3262 (I.K) L.5.74 B3263 (I.K) L.5.75 B3264 (I.K)
L.5.76 B3265 (I.K) L.5.77 B3266 (I.K) L.5.78 B3267 (I.K) L.5.79
B3268 (I.K) L.5.80 B3269 (I.K) L.5.81 B3270 (I.K) L.5.82 B3271
(I.K) L.5.83 B3272 (I.K) L.5.84 B3273 (I.K) L.6.1 B3274 (I.K) L.6.2
B3275 (I.K) L.6.3 B3276 (I.K) L.6.4 B3277 (I.K) L.6.5 B3278 (I.K)
L.6.6 B3279 (I.K) L.6.7 B3280 (I.K) L.6.8 B3281 (I.K) L.6.9 B3282
(I.K) L.6.10 B3283 (I.K) L.6.11 B3284 (I.K) L.6.12 B3285 (I.K)
L.6.13 B3286 (I.K) L.6.14 B3287 (I.K) L.6.15 B3288 (I.K) L.6.16
B3289 (I.K) L.6.17 B3990 (I.K) L.6.18 B = Mixture; I = compound I;
II = compound II
TABLE-US-00012 TABLE 60 B I II B3291 (I.L) L.1.1 B3292 (I.L) L.1.2
B3293 (I.L) L.1.3 B3294 (I.L) L.1.4 B3295 (I.L) L.1.5 B3296 (I.L)
L.1.6 B3297 (I.L) L.1.7 B3298 (I.L) L.1.8 B3299 (I.L) L.1.9 B3300
(I.L) L.1.10 B3301 (I.L) L.1.11 B3302 (I.L) L.1.12 B3303 (I.L)
L.1.13 B3304 (I.L) L.1.14 B3305 (I.L) L.1.15 B3306 (I.L) L.1.16
B3307 (I.L) L.1.17 B3308 (I.L) L.1.18 B3309 (I.L) L.1.19 B3310
(I.L) L.1.20 B3311 (I.L) L.1.21 B3312 (I.L) L.1.22 B3313 (I.L)
L.1.23 B3314 (I.L) L.1.24 B3315 (I.L) L.1.25 B3316 (I.L) L.1.26
B3317 (I.L) L.1.27 B3318 (I.L) L.1.28 B3319 (I.L) L.1.29 B3320
(I.L) L.1.30 B3321 (I.L) L.1.31 B3322 (I.L) L.1.32 B3323 (I.L)
L.1.33 B3324 (I.L) L.1.34 B3325 (I.L) L.1.35 B3326 (I.L) L.1.36
B3327 (I.L) L.1.37 B3328 (I.L) L.1.38 B3329 (I.L) L.1.39 B3330
(I.L) L.1.40 B3331 (I.L) L.1.41 B3332 (I.L) L.1.42 B3333 (I.L)
L.1.43 B3334 (I.L) L.1.44 B3335 (I.L) L.1.45 B3336 (I.L) L.1.46
B3337 (I.L) L.1.47 B3338 (I.L) L.1.48 B3339 (I.L) L.1.49 B3340
(I.L) L.1.50 B3341 (I.L) L.1.51 B3342 (I.L) L.1.52 B3343 (I.L)
L.1.53 B3344 (I.L) L.1.54 B3345 (I.L) L.1.55 B3346 (I.L) L.1.56
B3347 (I.L) L.1.57 B3348 (I.L) L.1.58 B3349 (I.L) L.1.59 B3350
(I.L) L.1.60 B3351 (I.L) L.1.61 B3352 (I.L) L.1.62 B3353 (I.L)
L.1.63 B3354 (I.L) L.1.64 B3355 (I.L) L.1.65 B3356 (I.L) L.1.66
B3357 (I.L) L.1.67 B3358 (I.L) L.1.68 B3359 (I.L) L.1.69 B3360
(I.L) L.1.70 B3361 (I.L) L.1.71 B3362 (I.L) L.1.72 B3363 (I.L)
L.1.73 B3364 (I.L) L.1.74 B3365 (I.L) L.1.75 B3366 (I.L) L.1.76
B3367 (I.L) L.1.77 B3368 (I.L) L.1.78 B3369 (I.L) L.1.79 B3370
(I.L) L.1.80 B3371 (I.L) L.1.81 B3372 (I.L) L.1.82 B3373 (I.L)
L.1.83 B3374 (I.L) L.1.84 B3375 (I.L) L.1.85 B3376 (I.L) L.1.86
B3377 (I.L) L.1.87 B3378 (I.L) L.1.88 B3379 (I.L) L.1.89 B3380
(I.L) L.1.90 B3381 (I.L) L.1.91 B3382 (I.L) L.1.92 B3383 (I.L)
L.1.93 B3384 (I.L) L.1.94 B3385 (I.L) L.1.95 B3386 (I.L) L.1.96
B3387 (I.L) L.2.1 B3388 (I.L) L.2.2 B3389 (I.L) L.2.3 B3390 (I.L)
L.2.4 B3391 (I.L) L.2.5 B3392 (I.L) L.2.6 B3393 (I.L) L.2.7 B3394
(I.L) L.2.8 B3395 (I.L) L.2.9 B3396 (I.L) L.2.10 B3397 (I.L) L.2.11
B3398 (I.L) L.2.12 B3399 (I.L) L.2.13 B3400 (I.L) L.2.14 B3401
(I.L) L.2.15 B3402 (I.L) L.2.16 B3403 (I.L) L.2.17 B3404 (I.L)
L.2.18 B3405 (I.L) L.2.19 B3406 (I.L) L.2.20 B3407 (I.L) L.2.21
B3408 (I.L) L.2.22 B3409 (I.L) L.2.23 B3410 (I.L) L.2.24 B3411
(I.L) L.2.25 B3412 (I.L) L.2.26 B3413 (I.L) L.2.27 B3414 (I.L)
L.2.28 B3415 (I.L) L.2.29 B3416 (I.L) L.2.30 B3417 (I.L) L.2.31
B3418 (I.L) L.2.32 B3419 (I.L) L.2.33 B3420 (I.L) L.3.1 B3421 (I.L)
L.3.2 B3422 (I.L) L.3.3 B3423 (I.L) L.3.4 B3424 (I.L) L.3.5 B3425
(I.L) L.3.6 B3426 (I.L) L.3.7 B3427 (I.L) L.3.8 B3428 (I.L) L.3.9
B3429 (I.L) L.3.10 B3430 (I.L) L.3.11 B3431 (I.L) L.3.12 B3432
(I.L) L.3.13 B3433 (I.L) L.3.14 B3434 (I.L) L.3.15 B3435 (I.L)
L.3.16 B3436 (I.L) L.3.17 B3437 (I.L) L.3.18 B3438 (I.L) L.3.19
B3439 (I.L) L.3.20 B3440 (I.L) L.3.21 B3441 (I.L) L.3.22 B3442
(I.L) L.3.23 B3443 (I.L) L.3.24 B3444 (I.L) L.3.25 B3445 (I.L)
L.3.26 B3446 (I.L) L.3.27 B3447 (I.L) L.3.28 B3448 (I.L) L.3.29
B3449 (I.L) L.3.30 B3450 (I.L) L.3.31 B3451 (I.L) L.3.32 B3452
(I.L) L.3.33 B3453 (I.L) L.3.34 B3454 (I.L) L.3.35 B3455 (I.L)
L.3.36 B3456 (I.L) L.3.37 B3457 (I.L) L.3.38 B3458 (I.L) L.3.39
B3459 (I.L) L.3.40 B3460 (I.L) L.3.41 B3461 (I.L) L.3.42 B3462
(I.L) L.3.43 B3463 (I.L) L.3.44 B3464 (I.L) L.3.45 B3465 (I.L)
L.3.46 B3466 (I.L) L.3.47 B3467 (I.L) L.3.48 B3468 (I.L) L.3.49
B3469 (I.L) L.3.50 B3470 (I.L) L.3.51 B3471 (I.L) L.3.52 B3472
(I.L) L.3.53 B3473 (I.L) L.3.54 B3474 (I.L) L.3.55 B3475 (I.L)
L.3.56 B3476 (I.L) L.3.57 B3477 (I.L) L.3.58 B3478 (I.L) L.3.59
B3479 (I.L) L.3.60 B3480 (I.L) L.3.61 B3481 (I.L) L.3.62 B3482
(I.L) L.3.63 B3483 (I.L) L.3.1 B3484 (I.L) L.3.2 B3485 (I.L) L.4.1
B3486 (I.L) L.4.2 B3487 (I.L) L.4.3 B3488 (I.L) L.4.4 B3489 (I.L)
L.4.5 B3490 (I.L) L.4.6 B3491 (I.L) L.4.7 B3492 (I.L) L.4.8 B3493
(I.L) L.4.9 B3494 (I.L) L.4.10 B3495 (I.L) L.4.11 B3496 (I.L)
L.4.12 B3497 (I.L) L.4.13 B3498 (I.L) L.4.14 B3499 (I.L) L.4.15
B3500 (I.L) L.4.16 B3501 (I.L) L.4.17 B3502 (I.L) L.4.18 B3503
(I.L) L.4.19 B3504 (I.L) L.4.20 B3505 (I.L) L.4.21 B3506 (I.L)
L.4.22 B3507 (I.L) L.4.23 B3508 (I.L) L.4.24 B3509 (I.L) L.4.25
B3510 (I.L) L.4.26 B3511 (I.L) L.4.27 B3512 (I.L) L.4.28 B3513
(I.L) L.4.29 B3514 (I.L) L.4.30 B3515 (I.L) L.4.31 B3516 (I.L)
L.4.32 B3517 (I.L) L.4.33 B3518 (I.L) L.5.1 B3519 (I.L) L.5.2 B3520
(I.L) L.5.3 B3521 (I.L) L.5.4 B3522 (I.L) L.5.5 B3523 (I.L) L.5.6
B3524 (I.L) L.5.7 B3525 (I.L) L.5.8 B3526 (I.L) L.5.9 B3527 (I.L)
L.5.10 B3528 (I.L) L.5.11 B3529 (I.L) L.5.12 B3530 (I.L) L.5.13
B3531 (I.L) L.5.14 B3532 (I.L) L.5.15 B3533 (I.L) L.5.16 B3534
(I.L) L.5.17 B3535 (I.L) L.5.18 B3536 (I.L) L.5.19
B3537 (I.L) L.5.20 B3538 (I.L) L.5.21 B3539 (I.L) L.5.22 B3540
(I.L) L.5.23 B3541 (I.L) L.5.24 B3542 (I.L) L.5.25 B3543 (I.L)
L.5.26 B3544 (I.L) L.5.27 B3545 (I.L) L.5.28 B3546 (I.L) L.5.29
B3547 (I.L) L.5.30 B3548 (I.L) L.5.31 B3549 (I.L) L.5.32 B3550
(I.L) L.5.33 B3551 (I.L) L.5.34 B3552 (I.L) L.5.35 B3553 (I.L)
L.5.36 B3554 (I.L) L.5.37 B3555 (I.L) L.5.38 B3556 (I.L) L.5.39
B3557 (I.L) L.5.40 B3558 (I.L) L.5.41 B3559 (I.L) L.5.42 B3560
(I.L) L.5.43 B3561 (I.L) L.5.44 B3562 (I.L) L.5.45 B3563 (I.L)
L.5.46 B3564 (I.L) L.5.47 B3565 (I.L) L.5.48 B3566 (I.L) L.5.49
B3567 (I.L) L.5.50 B3568 (I.L) L.5.51 B3569 (I.L) L.5.52 B3570
(I.L) L.5.53 B3571 (I.L) L.5.54 B3572 (I.L) L.5.55 B3573 (I.L)
L.5.56 B3574 (I.L) L.5.57 B3575 (I.L) L.5.58 B3576 (I.L) L.5.59
B3577 (I.L) L.5.60 B3578 (I.L) L.5.61 B3579 (I.L) L.5.62 B3580
(I.L) L.5.63 B3581 (I.L) L.5.64 B3582 (I.L) L.5.65 B3583 (I.L)
L.5.66 B3584 (I.L) L.5.67 B3585 (I.L) L.5.68 B3586 (I.L) L.5.69
B3587 (I.L) L.5.70 B3588 (I.L) L.5.71 B3589 (I.L) L.5.72 B3590
(I.L) L.5.73 B3591 (I.L) L.5.74 B3592 (I.L) L.5.75 B3593 (I.L)
L.5.76 B3594 (I.L) L.5.77 B3595 (I.L) L.5.78 B3596 (I.L) L.5.79
B3597 (I.L) L.5.80 B3598 (I.L) L.5.81 B3599 (I.L) L.5.82 B3600
(I.L) L.5.83 B3601 (I.L) L.5.84 B3602 (I.L) L.6.1 B3603 (I.L) L.6.2
B3604 (I.L) L.6.3 B3605 (I.L) L.6.4 B3606 (I.L) L.6.5 B3607 (I.L)
L.6.6 B3608 (I.L) L.6.7 B3609 (I.L) L.6.8 B3610 (I.L) L.6.9 B3611
(I.L) L.6.10 B3612 (I.L) L.6.11 B3613 (I.L) L.6.12 B3614 (I.L)
L.6.13 B3615 (I.L) L.6.14 B3616 (I.L) L.6.15 B3617 (I.L) L.6.16
B3618 (I.L) L.6.17 B3619 (I.L) L.6.18 B = Mixture; I = compound I;
II = compound II
TABLE-US-00013 TABLE 61 B I II B3620 (I.M) L.1.1 B3621 (I.M) L.1.2
B3622 (I.M) L.1.3 B3623 (I.M) L.1.4 B3624 (I.M) L.1.5 B3625 (I.M)
L.1.6 B3626 (I.M) L.1.7 B3627 (I.M) L.1.8 B3628 (I.M) L.1.9 B3629
(I.M) L.1.10 B3630 (I.M) L.1.11 B3631 (I.M) L.1.12 B3632 (I.M)
L.1.13 B3633 (I.M) L.1.14 B3634 (I.M) L.1.15 B3635 (I.M) L.1.16
B3636 (I.M) L.1.17 B3637 (I.M) L.1.18 B3638 (I.M) L.1.19 B3639
(I.M) L.1.20 B3640 (I.M) L.1.21 B3641 (I.M) L.1.22 B3642 (I.M)
L.1.23 B3643 (I.M) L.1.24 B3644 (I.M) L.1.25 B3645 (I.M) L.1.26
B3646 (I.M) L.1.27 B3647 (I.M) L.1.28 B3648 (I.M) L.1.29 B3649
(I.M) L.1.30 B3650 (I.M) L.1.31 B3651 (I.M) L.1.32 B3652 (I.M)
L.1.33 B3653 (I.M) L.1.34 B3654 (I.M) L.1.35 B3655 (I.M) L.1.36
B3656 (I.M) L.1.37 B3657 (I.M) L.1.38 B3658 (I.M) L.1.39 B3659
(I.M) L.1.40 B3660 (I.M) L.1.41 B3661 (I.M) L.1.42 B3662 (I.M)
L.1.43 B3663 (I.M) L.1.44 B3664 (I.M) L.1.45 B3665 (I.M) L.1.46
B3666 (I.M) L.1.47 B3667 (I.M) L.1.48 B3668 (I.M) L.1.49 B3669
(I.M) L.1.50 B3670 (I.M) L.1.51 B3671 (I.M) L.1.52 B3672 (I.M)
L.1.53 B3673 (I.M) L.1.54 B3674 (I.M) L.1.55 B3675 (I.M) L.1.56
B3676 (I.M) L.1.57 B3677 (I.M) L.1.58 B3678 (I.M) L.1.59 B3679
(I.M) L.1.60 B3680 (I.M) L.1.61 B3681 (I.M) L.1.62 B3682 (I.M)
L.1.63 B3683 (I.M) L.1.64 B3684 (I.M) L.1.65 B3685 (I.M) L.1.66
B3686 (I.M) L.1.67 B3687 (I.M) L.1.68 B3688 (I.M) L.1.69 B3689
(I.M) L.1.70 B3690 (I.M) L.1.71 B3691 (I.M) L.1.72 B3692 (I.M)
L.1.73 B3693 (I.M) L.1.74 B3694 (I.M) L.1.75 B3695 (I.M) L.1.76
B3696 (I.M) L.1.77 B3697 (I.M) L.1.78 B3698 (I.M) L.1.79 B3699
(I.M) L.1.80 B3700 (I.M) L.1.81 B3701 (I.M) L.1.82 B3702 (I.M)
L.1.83 B3703 (I.M) L.1.84 B3704 (I.M) L.1.85 B3705 (I.M) L.1.86
B3706 (I.M) L.1.87 B3707 (I.M) L.1.88 B3708 (I.M) L.1.89 B3709
(I.M) L.1.90 B3710 (I.M) L.1.91 B3711 (I.M) L.1.92 B3712 (I.M)
L.1.93 B3713 (I.M) L.1.94 B3714 (I.M) L.1.95 B3715 (I.M) L.1.96
B3716 (I.M) L.2.1 B3717 (I.M) L.2.2 B3718 (I.M) L.2.3 B3719 (I.M)
L.2.4 B3720 (I.M) L.2.5 B3721 (I.M) L.2.6 B3722 (I.M) L.2.7 B3723
(I.M) L.2.8 B3724 (I.M) L.2.9 B3725 (I.M) L.2.10 B3726 (I.M) L.2.11
B3727 (I.M) L.2.12 B3728 (I.M) L.2.13 B3729 (I.M) L.2.14 B3730
(I.M) L.2.15 B3731 (I.M) L.2.16 B3732 (I.M) L.2.17 B3733 (I.M)
L.2.18 B3734 (I.M) L.2.19 B3735 (I.M) L.2.20 B3736 (I.M) L.2.21
B3737 (I.M) L.2.22 B3738 (I.M) L.2.23 B3739 (I.M) L.2.24 B3740
(I.M) L.2.25 B3741 (I.M) L.2.26 B3742 (I.M) L.2.27 B3743 (I.M)
L.2.28 B3744 (I.M) L.2.29 B3745 (I.M) L.2.30 B3746 (I.M) L.2.31
B3747 (I.M) L.2.32 B3748 (I.M) L.2.33 B3749 (I.M) L.3.1 B3750 (I.M)
L.3.2 B3751 (I.M) L.3.3 B3752 (I.M) L.3.4 B3753 (I.M) L.3.5 B3754
(I.M) L.3.6 B3755 (I.M) L.3.7 B3756 (I.M) L.3.8 B3757 (I.M) L.3.9
B3758 (I.M) L.3.10 B3759 (I.M) L.3.11 B3760 (I.M) L.3.12 B3761
(I.M) L.3.13 B3762 (I.M) L.3.14 B3763 (I.M) L.3.15 B3764 (I.M)
L.3.16 B3765 (I.M) L.3.17 B3766 (I.M) L.3.18 B3767 (I.M) L.3.19
B3768 (I.M) L.3.20 B3769 (I.M) L.3.21 B3770 (I.M) L.3.22 B3771
(I.M) L.3.23 B3772 (I.M) L.3.24 B3773 (I.M) L.3.25 B3774 (I.M)
L.3.26 B3775 (I.M) L.3.27 B3776 (I.M) L.3.28 B3777 (I.M) L.3.29
B3778 (I.M) L.3.30 B3779 (I.M) L.3.31 B3780 (I.M) L.3.32 B3781
(I.M) L.3.33 B3782 (I.M) L.3.34 B3783 (I.M) L.3.35 B3784 (I.M)
L.3.36 B3785 (I.M) L.3.37 B3786 (I.M) L.3.38 B3787 (I.M) L.3.39
B3788 (I.M) L.3.40 B3789 (I.M) L.3.41 B3790 (I.M) L.3.42 B3791
(I.M) L.3.43 B3792 (I.M) L.3.44 B3793 (I.M) L.3.45 B3794 (I.M)
L.3.46 B3795 (I.M) L.3.47 B3796 (I.M) L.3.48 B3797 (I.M) L.3.49
B3798 (I.M) L.3.50 B3799 (I.M) L.3.51 B3800 (I.M) L.3.52 B3801
(I.M) L.3.53 B3802 (I.M) L.3.54 B3803 (I.M) L.3.55 B3804 (I.M)
L.3.56 B3805 (I.M) L.3.57 B3806 (I.M) L.3.58 B3807 (I.M) L.3.59
B3808 (I.M) L.3.60 B3809 (I.M) L.3.61 B3810 (I.M) L.3.62 B3811
(I.M) L.3.63 B3812 (I.M) L.3.1 B3813 (I.M) L.3.2 B3814 (I.M) L.4.1
B3815 (I.M) L.4.2 B3816 (I.M) L.4.3 B3817 (I.M) L.4.4 B3818 (I.M)
L.4.5 B3819 (I.M) L.4.6 B3820 (I.M) L.4.7 B3821 (I.M) L.4.8 B3822
(I.M) L.4.9 B3823 (I.M) L.4.10 B3824 (I.M) L.4.11 B3825 (I.M)
L.4.12 B3826 (I.M) L.4.13 B3827 (I.M) L.4.14 B3828 (I.M) L.4.15
B3829 (I.M) L.4.16 B3830 (I.M) L.4.17 B3831 (I.M) L.4.18 B3832
(I.M) L.4.19 B3833 (I.M) L.4.20 B3834 (I.M) L.4.21 B3835 (I.M)
L.4.22 B3836 (I.M) L.4.23 B3837 (I.M) L.4.24 B3838 (I.M) L.4.25
B3839 (I.M) L.4.26 B3840 (I.M) L.4.27 B3841 (I.M) L.4.28 B3842
(I.M) L.4.29 B3843 (I.M) L.4.30 B3844 (I.M) L.4.31 B3845 (I.M)
L.4.32 B3846 (I.M) L.4.33 B3847 (I.M) L.5.1 B3848 (I.M) L.5.2 B3849
(I.M) L.5.3 B3850 (I.M) L.5.4 B3851 (I.M) L.5.5 B3852 (I.M) L.5.6
B3853 (I.M) L.5.7 B3854 (I.M) L.5.8 B3855 (I.M) L.5.9 B3856 (I.M)
L.5.10 B3857 (I.M) L.5.11 B3858 (I.M) L.5.12 B3859 (I.M) L.5.13
B3860 (I.M) L.5.14 B3861 (I.M) L.5.15 B3862 (I.M) L.5.16 B3863
(I.M) L.5.17 B3864 (I.M) L.5.18 B3865 (I.M) L.5.19
B3866 (I.M) L.5.20 B3867 (I.M) L.5.21 B3868 (I.M) L.5.22 B3869
(I.M) L.5.23 B3870 (I.M) L.5.24 B3871 (I.M) L.5.25 B3872 (I.M)
L.5.26 B3873 (I.M) L.5.27 B3874 (I.M) L.5.28 B3875 (I.M) L.5.29
B3876 (I.M) L.5.30 B3877 (I.M) L.5.31 B3878 (I.M) L.5.32 B3879
(I.M) L.5.33 B3880 (I.M) L.5.34 B3881 (I.M) L.5.35 B3882 (I.M)
L.5.36 B3883 (I.M) L.5.37 B3884 (I.M) L.5.38 B3885 (I.M) L.5.39
B3886 (I.M) L.5.40 B3887 (I.M) L.5.41 B3888 (I.M) L.5.42 B3889
(I.M) L.5.43 B3890 (I.M) L.5.44 B3891 (I.M) L.5.45 B3892 (I.M)
L.5.46 B3893 (I.M) L.5.47 B3894 (I.M) L.5.48 B3895 (I.M) L.5.49
B3896 (I.M) L.5.50 B3897 (I.M) L.5.51 B3898 (I.M) L.5.52 B3899
(I.M) L.5.53 B3900 (I.M) L.5.54 B3901 (I.M) L.5.55 B3902 (I.M)
L.5.56 B3903 (I.M) L.5.57 B3904 (I.M) L.5.58 B3905 (I.M) L.5.59
B3906 (I.M) L.5.60 B3907 (I.M) L.5.61 B3908 (I.M) L.5.62 B3909
(I.M) L.5.63 B3910 (I.M) L.5.64 B3911 (I.M) L.5.65 B3912 (I.M)
L.5.66 B3913 (I.M) L.5.67 B3914 (I.M) L.5.68 B3915 (I.M) L.5.69
B3916 (I.M) L.5.70 B3917 (I.M) L.5.71 B3918 (I.M) L.5.72 B3919
(I.M) L.5.73 B3920 (I.M) L.5.74 B3921 (I.M) L.5.75 B3922 (I.M)
L.5.76 B3923 (I.M) L.5.77 B3924 (I.M) L.5.78 B3925 (I.M) L.5.79
B3926 (I.M) L.5.80 B3927 (I.M) L.5.81 B3928 (I.M) L.5.82 B3929
(I.M) L.5.83 B3930 (I.M) L.5.84 B3931 (I.M) L.6.1 B3932 (I.M) L.6.2
B3933 (I.M) L.6.3 B3934 (I.M) L.6.4 B3935 (I.M) L.6.5 B3936 (I.M)
L.6.6 B3937 (I.M) L.6.7 B3938 (I.M) L.6.8 B3939 (I.M) L.6.9 B3940
(I.M) L.6.10 B3941 (I.M) L.6.11 B3942 (I.M) L.6.12 B3943 (I.M)
L.6.13 B3944 (I.M) L.6.14 B3945 (I.M) L.6.15 B3946 (I.M) L.6.16
B3947 (I.M) L.6.17 B3948 (I.M) L.6.18 B = Mixture; I = compound I;
II = compound II
TABLE-US-00014 TABLE 62 B I II B3949 (I.N) L.1.1 B3950 (I.N) L.1.2
B3951 (I.N) L.1.3 B3952 (I.N) L.1.4 B3953 (I.N) L.1.5 B3954 (I.N)
L.1.6 B3955 (I.N) L.1.7 B3956 (I.N) L.1.8 B3957 (I.N) L.1.9 B3958
(I.N) L.1.10 B3959 (I.N) L.1.11 B3960 (I.N) L.1.12 B3961 (I.N)
L.1.13 B3962 (I.N) L.1.14 B3963 (I.N) L.1.15 B3964 (I.N) L.1.16
B3965 (I.N) L.1.17 B3966 (I.N) L.1.18 B3967 (I.N) L.1.19 B3968
(I.N) L.1.20 B3969 (I.N) L.1.21 B3970 (I.N) L.1.22 B3971 (I.N)
L.1.23 B3972 (I.N) L.1.24 B3973 (I.N) L.1.25 B3974 (I.N) L.1.26
B3975 (I.N) L.1.27 B3976 (I.N) L.1.28 B3977 (I.N) L.1.29 B3978
(I.N) L.1.30 B3979 (I.N) L.1.31 B3980 (I.N) L.1.32 B3981 (I.N)
L.1.33 B3982 (I.N) L.1.34 B3983 (I.N) L.1.35 B3984 (I.N) L.1.36
B3985 (I.N) L.1.37 B3986 (I.N) L.1.38 B3987 (I.N) L.1.39 B3988
(I.N) L.1.40 B3989 (I.N) L.1.41 B3990 (I.N) L.1.42 B3991 (I.N)
L.1.43 B3992 (I.N) L.1.44 B3993 (I.N) L.1.45 B3994 (I.N) L.1.46
B3995 (I.N) L.1.47 B3996 (I.N) L.1.48 B3997 (I.N) L.1.49 B3998
(I.N) L.1.50 B3999 (I.N) L.1.51 B4000 (I.N) L.1.52 B4001 (I.N)
L.1.53 B4002 (I.N) L.1.54 B4003 (I.N) L.1.55 B4004 (I.N) L.1.56
B4005 (I.N) L.1.57 B4006 (I.N) L.1.58 B4007 (I.N) L.1.59 B4008
(I.N) L.1.60 B4009 (I.N) L.1.61 B4010 (I.N) L.1.62 B4011 (I.N)
L.1.63 B4012 (I.N) L.1.64 B4013 (I.N) L.1.65 B4014 (I.N) L.1.66
B4015 (I.N) L.1.67 B4016 (I.N) L.1.68 B4017 (I.N) L.1.69 B4018
(I.N) L.1.70 B4019 (I.N) L.1.71 B4020 (I.N) L.1.72 B4021 (I.N)
L.1.73 B4022 (I.N) L.1.74 B4023 (I.N) L.1.75 B4024 (I.N) L.1.76
B4025 (I.N) L.1.77 B4026 (I.N) L.1.78 B4027 (I.N) L.1.79 B4028
(I.N) L.1.80 B4029 (I.N) L.1.81 B4030 (I.N) L.1.82 B4031 (I.N)
L.1.83 B4032 (I.N) L.1.84 B4033 (I.N) L.1.85 B4034 (I.N) L.1.86
B4035 (I.N) L.1.87 B4036 (I.N) L.1.88 B4037 (I.N) L.1.89 B4038
(I.N) L.1.90 B4039 (I.N) L.1.91 B4040 (I.N) L.1.92 B4041 (I.N)
L.1.93 B4042 (I.N) L.1.94 B4043 (I.N) L.1.95 B4044 (I.N) L.1.96
B4045 (I.N) L.2.1 B4046 (I.N) L.2.2 B4047 (I.N) L.2.3 B4048 (I.N)
L.2.4 B4049 (I.N) L.2.5 B4050 (I.N) L.2.6 B4051 (I.N) L.2.7 B4052
(I.N) L.2.8 B4053 (I.N) L.2.9 B4054 (I.N) L.2.10 B4055 (I.N) L.2.11
B4056 (I.N) L.2.12 B4057 (I.N) L.2.13 B4058 (I.N) L.2.14 B4059
(I.N) L.2.15 B4060 (I.N) L.2.16 B4061 (I.N) L.2.17 B4062 (I.N)
L.2.18 B4063 (I.N) L.2.19 B4064 (I.N) L.2.20 B4065 (I.N) L.2.21
B4066 (I.N) L.2.22 B4067 (I.N) L.2.23 B4068 (I.N) L.2.24 B4069
(I.N) L.2.25 B4070 (I.N) L.2.26 B4071 (I.N) L.2.27 B4072 (I.N)
L.2.28 B4073 (I.N) L.2.29 B4074 (I.N) L.2.30 B4075 (I.N) L.2.31
B4076 (I.N) L.2.32 B4077 (I.N) L.2.33 B4078 (I.N) L.3.1 B4079 (I.N)
L.3.2 B4080 (I.N) L.3.3 B4081 (I.N) L.3.4 B4082 (I.N) L.3.5 B4083
(I.N) L.3.6 B4084 (I.N) L.3.7 B4085 (I.N) L.3.8 B4086 (I.N) L.3.9
B4087 (I.N) L.3.10 B4088 (I.N) L.3.11 B4089 (I.N) L.3.12 B4090
(I.N) L.3.13 B4091 (I.N) L.3.14 B4092 (I.N) L.3.15 B4093 (I.N)
L.3.16 B4094 (I.N) L.3.17 B4095 (I.N) L.3.18 B4096 (I.N) L.3.19
B4097 (I.N) L.3.20 B4098 (I.N) L.3.21 B4099 (I.N) L.3.22 B4100
(I.N) L.3.23 B4101 (I.N) L.3.24 B4102 (I.N) L.3.25 B4103 (I.N)
L.3.26 B4104 (I.N) L.3.27 B4105 (I.N) L.3.28 B4106 (I.N) L.3.29
B4107 (I.N) L.3.30 B4108 (I.N) L.3.31 B4109 (I.N) L.3.32 B4110
(I.N) L.3.33 B4111 (I.N) L.3.34 B4112 (I.N) L.3.35 B4113 (I.N)
L.3.36 B4114 (I.N) L.3.37 B4115 (I.N) L.3.38 B4116 (I.N) L.3.39
B4117 (I.N) L.3.40 B4118 (I.N) L.3.41 B4119 (I.N) L.3.42 B4120
(I.N) L.3.43 B4121 (I.N) L.3.44 B4122 (I.N) L.3.45 B4123 (I.N)
L.3.46 B4124 (I.N) L.3.47 B4125 (I.N) L.3.48 B4126 (I.N) L.3.49
B4127 (I.N) L.3.50 B4128 (I.N) L.3.51 B4129 (I.N) L.3.52 B4130
(I.N) L.3.53 B4131 (I.N) L.3.54 B4132 (I.N) L.3.55 B4133 (I.N)
L.3.56 B4134 (I.N) L.3.57 B4135 (I.N) L.3.58 B4136 (I.N) L.3.59
B4137 (I.N) L.3.60 B4138 (I.N) L.3.61 B4139 (I.N) L.3.62 B4140
(I.N) L.3.63 B4141 (I.N) L.3.1 B4142 (I.N) L.3.2 B4143 (I.N) L.4.1
B4144 (I.N) L.4.2 B4145 (I.N) L.4.3 B4146 (I.N) L.4.4 B4147 (I.N)
L.4.5 B4148 (I.N) L.4.6 B4149 (I.N) L.4.7 B4150 (I.N) L.4.8 B4151
(I.N) L.4.9 B4152 (I.N) L.4.10 B4153 (I.N) L.4.11 B4154 (I.N)
L.4.12 B4155 (I.N) L.4.13 B4156 (I.N) L.4.14 B4157 (I.N) L.4.15
B4158 (I.N) L.4.16 B4159 (I.N) L.4.17 B4160 (I.N) L.4.18 B4161
(I.N) L.4.19 B4162 (I.N) L.4.20 B4163 (I.N) L.4.21 B4164 (I.N)
L.4.22 B4165 (I.N) L.4.23 B4166 (I.N) L.4.24 B4167 (I.N) L.4.25
B4168 (I.N) L.4.26 B4169 (I.N) L.4.27 B4170 (I.N) L.4.28 B4171
(I.N) L.4.29 B4172 (I.N) L.4.30 B4173 (I.N) L.4.31 B4174 (I.N)
L.4.32 B4175 (I.N) L.4.33 B4176 (I.N) L.5.1 B4177 (I.N) L.5.2 B4178
(I.N) L.5.3 B4179 (I.N) L.5.4 B4180 (I.N) L.5.5 B4181 (I.N) L.5.6
B4182 (I.N) L.5.7 B4183 (I.N) L.5.8 B4184 (I.N) L.5.9 B4185 (I.N)
L.5.10 B4186 (I.N) L.5.11 B4187 (I.N) L.5.12 B4188 (I.N) L.5.13
B4189 (I.N) L.5.14 B4190 (I.N) L.5.15 B4191 (I.N) L.5.16 B4192
(I.N) L.5.17 B4193 (I.N) L.5.18 B4194 (I.N) L.5.19
B4195 (I.N) L.5.20 B4196 (I.N) L.5.21 B4197 (I.N) L.5.22 B4198
(I.N) L.5.23 B4199 (I.N) L.5.24 B4200 (I.N) L.5.25 B4201 (I.N)
L.5.26 B4202 (I.N) L.5.27 B4203 (I.N) L.5.28 B4204 (I.N) L.5.29
B4205 (I.N) L.5.30 B4206 (I.N) L.5.31 B4207 (I.N) L.5.32 B4208
(I.N) L.5.33 B4209 (I.N) L.5.34 B4210 (I.N) L.5.35 B4211 (I.N)
L.5.36 B4212 (I.N) L.5.37 B4213 (I.N) L.5.38 B4214 (I.N) L.5.39
B4215 (I.N) L.5.40 B4216 (I.N) L.5.41 B4217 (I.N) L.5.42 B4218
(I.N) L.5.43 B4219 (I.N) L.5.44 B4220 (I.N) L.5.45 B4221 (I.N)
L.5.46 B4222 (I.N) L.5.47 B4223 (I.N) L.5.48 B4224 (I.N) L.5.49
B4225 (I.N) L.5.50 B4226 (I.N) L.5.51 B4227 (I.N) L.5.52 B4228
(I.N) L.5.53 B4229 (I.N) L.5.54 B4230 (I.N) L.5.55 B4231 (I.N)
L.5.56 B4232 (I.N) L.5.57 B4233 (I.N) L.5.58 B4234 (I.N) L.5.59
B4235 (I.N) L.5.60 B4236 (I.N) L.5.61 B4237 (I.N) L.5.62 B4238
(I.N) L.5.63 B4239 (I.N) L.5.64 B4240 (I.N) L.5.65 B4241 (I.N)
L.5.66 B4242 (I.N) L.5.67 B4243 (I.N) L.5.68 B4244 (I.N) L.5.69
B4245 (I.N) L.5.70 B4246 (I.N) L.5.71 B4247 (I.N) L.5.72 B4248
(I.N) L.5.73 B4249 (I.N) L.5.74 B4250 (I.N) L.5.75 B4251 (I.N)
L.5.76 B4252 (I.N) L.5.77 B4253 (I.N) L.5.78 B4254 (I.N) L.5.79
B4255 (I.N) L.5.80 B4256 (I.N) L.5.81 B4257 (I.N) L.5.82 B4258
(I.N) L.5.83 B4259 (I.N) L.5.84 B4260 (I.N) L.6.1 B4261 (I.N) L.6.2
B4262 (I.N) L.6.3 B4263 (I.N) L.6.4 B4264 (I.N) L.6.5 B4265 (I.N)
L.6.6 B4266 (I.N) L.6.7 B4267 (I.N) L.6.8 B4268 (I.N) L.6.9 B4269
(I.N) L.6.10 B4270 (I.N) L.6.11 B4271 (I.N) L.6.12 B4272 (I.N)
L.6.13 B4273 (I.N) L.6.14 B4274 (I.N) L.6.15 B4275 (I.N) L.6.16
B4276 (I.N) L.6.17 B4277 (I.N) L.6.18 B = Mixture; I = compound I;
II = compound II;
TABLE-US-00015 TABLE 63 B I II B4278 (I.O) L.1.1 B4279 (I.O) L.1.2
B4280 (I.O) L.1.3 B4281 (I.O) L.1.4 B4282 (I.O) L.1.5 B4283 (I.O)
L.1.6 B4284 (I.O) L.1.7 B4285 (I.O) L.1.8 B4286 (I.O) L.1.9 B4287
(I.O) L.1.10 B4288 (I.O) L.1.11 B4289 (I.O) L.1.12 B4290 (I.O)
L.1.13 B4291 (I.O) L.1.14 B4292 (I.O) L.1.15 B4293 (I.O) L.1.16
B4294 (I.O) L.1.17 B4295 (I.O) L.1.18 B4296 (I.O) L.1.19 B4297
(I.O) L.1.20 B4298 (I.O) L.1.21 B4299 (I.O) L.1.22 B4300 (I.O)
L.1.23 B4301 (I.O) L.1.24 B4302 (I.O) L.1.25 B4303 (I.O) L.1.26
B4304 (I.O) L.1.27 B4305 (I.O) L.1.28 B4306 (I.O) L.1.29 B4307
(I.O) L.1.30 B4308 (I.O) L.1.31 B4309 (I.O) L.1.32 B4310 (I.O)
L.1.33 B4311 (I.O) L.1.34 B4312 (I.O) L.1.35 B4313 (I.O) L.1.36
B4314 (I.O) L.1.37 B4315 (I.O) L.1.38 B4316 (I.O) L.1.39 B4317
(I.O) L.1.40 B4318 (I.O) L.1.41 B4319 (I.O) L.1.42 B4320 (I.O)
L.1.43 B4321 (I.O) L.1.44 B4322 (I.O) L.1.45 B4323 (I.O) L.1.46
B4324 (I.O) L.1.47 B4325 (I.O) L.1.48 B4326 (I.O) L.1.49 B4327
(I.O) L.1.50 B4328 (I.O) L.1.51 B4329 (I.O) L.1.52 B4330 (I.O)
L.1.53 B4331 (I.O) L.1.54 B4332 (I.O) L.1.55 B4333 (I.O) L.1.56
B4334 (I.O) L.1.57 B4335 (I.O) L.1.58 B4336 (I.O) L.1.59 B4337
(I.O) L.1.60 B4338 (I.O) L.1.61 B4339 (I.O) L.1.62 B4340 (I.O)
L.1.63 B4341 (I.O) L.1.64 B4342 (I.O) L.1.65 B4343 (I.O) L.1.66
B4344 (I.O) L.1.67 B4345 (I.O) L.1.68 B4346 (I.O) L.1.69 B4347
(I.O) L.1.70 B4348 (I.O) L.1.71 B4349 (I.O) L.1.72 B4350 (I.O)
L.1.73 B4351 (I.O) L.1.74 B4352 (I.O) L.1.75 B4353 (I.O) L.1.76
B4354 (I.O) L.1.77 B4355 (I.O) L.1.78 B4356 (I.O) L.1.79 B4357
(I.O) L.1.80 B4358 (I.O) L.1.81 B4359 (I.O) L.1.82 B4360 (I.O)
L.1.83 B4361 (I.O) L.1.84 B4362 (I.O) L.1.85 B4363 (I.O) L.1.86
B4364 (I.O) L.1.87 B4365 (I.O) L.1.88 B4366 (I.O) L.1.89 B4367
(I.O) L.1.90 B4368 (I.O) L.1.91 B4369 (I.O) L.1.92 B4370 (I.O)
L.1.93 B4371 (I.O) L.1.94 B4372 (I.O) L.1.95 B4373 (I.O) L.1.96
B4374 (I.O) L.2.1 B4375 (I.O) L.2.2 B4376 (I.O) L.2.3 B4377 (I.O)
L.2.4 B4378 (I.O) L.2.5 B4379 (I.O) L.2.6 B4380 (I.O) L.2.7 B4381
(I.O) L.2.8 B4382 (I.O) L.2.9 B4383 (I.O) L.2.10 B4384 (I.O) L.2.11
B4385 (I.O) L.2.12 B4386 (I.O) L.2.13 B4387 (I.O) L.2.14 B4388
(I.O) L.2.15 B4389 (I.O) L.2.16 B4390 (I.O) L.2.17 B4391 (I.O)
L.2.18 B4392 (I.O) L.2.19 B4393 (I.O) L.2.20 B4394 (I.O) L.2.21
B4395 (I.O) L.2.22 B4396 (I.O) L.2.23 B4397 (I.O) L.2.24 B4398
(I.O) L.2.25 B4399 (I.O) L.2.26 B4400 (I.O) L.2.27 B4401 (I.O)
L.2.28 B4402 (I.O) L.2.29 B4403 (I.O) L.2.30 B4404 (I.O) L.2.31
B4405 (I.O) L.2.32 B4406 (I.O) L.2.33 B4407 (I.O) L.3.1 B4408 (I.O)
L.3.2 B4409 (I.O) L.3.3 B4410 (I.O) L.3.4 B4411 (I.O) L.3.5 B4412
(I.O) L.3.6 B4413 (I.O) L.3.7 B4414 (I.O) L.3.8 B4415 (I.O) L.3.9
B4416 (I.O) L.3.10 B4417 (I.O) L.3.11 B4418 (I.O) L.3.12 B4419
(I.O) L.3.13 B4420 (I.O) L.3.14 B4421 (I.O) L.3.15 B4422 (I.O)
L.3.16 B4423 (I.O) L.3.17 B4424 (I.O) L.3.18 B4425 (I.O) L.3.19
B4426 (I.O) L.3.20 B4427 (I.O) L.3.21 B4428 (I.O) L.3.22 B4429
(I.O) L.3.23 B4430 (I.O) L.3.24 B4431 (I.O) L.3.25 B4432 (I.O)
L.3.26 B4433 (I.O) L.3.27 B4434 (I.O) L.3.28 B4435 (I.O) L.3.29
B4436 (I.O) L.3.30 B4437 (I.O) L.3.31 B4438 (I.O) L.3.32 B4439
(I.O) L.3.33 B4440 (I.O) L.3.34 B4441 (I.O) L.3.35 B4442 (I.O)
L.3.36 B4443 (I.O) L.3.37 B4444 (I.O) L.3.38 B4445 (I.O) L.3.39
B4446 (I.O) L.3.40 B4447 (I.O) L.3.41 B4448 (I.O) L.3.42 B4449
(I.O) L.3.43 B4450 (I.O) L.3.44 B4451 (I.O) L.3.45 B4452 (I.O)
L.3.46 B4453 (I.O) L.3.47 B4454 (I.O) L.3.48 B4455 (I.O) L.3.49
B4456 (I.O) L.3.50 B4457 (I.O) L.3.51 B4458 (I.O) L.3.52 B4459
(I.O) L.3.53 B4460 (I.O) L.3.54 B4461 (I.O) L.3.55 B4462 (I.O)
L.3.56 B4463 (I.O) L.3.57 B4464 (I.O) L.3.58 B4465 (I.O) L.3.59
B4466 (I.O) L.3.60 B4467 (I.O) L.3.61 B4468 (I.O) L.3.62 B4469
(I.O) L.3.63 B4470 (I.O) L.3.1 B4471 (I.O) L.3.2 B4472 (I.O) L.4.1
B4473 (I.O) L.4.2 B4474 (I.O) L.4.3 B4475 (I.O) L.4.4 B4476 (I.O)
L.4.5 B4477 (I.O) L.4.6 B4478 (I.O) L.4.7 B4479 (I.O) L.4.8 B4480
(I.O) L.4.9 B4481 (I.O) L.4.10 B4482 (I.O) L.4.11 B4483 (I.O)
L.4.12 B4484 (I.O) L.4.13 B4485 (I.O) L.4.14 B4486 (I.O) L.4.15
B4487 (I.O) L.4.16 B4488 (I.O) L.4.17 B4489 (I.O) L.4.18 B4490
(I.O) L.4.19 B4491 (I.O) L.4.20 B4492 (I.O) L.4.21 B4493 (I.O)
L.4.22 B4494 (I.O) L.4.23 B4495 (I.O) L.4.24 B4496 (I.O) L.4.25
B4497 (I.O) L.4.26 B4498 (I.O) L.4.27 B4499 (I.O) L.4.28 B4500
(I.O) L.4.29 B4501 (I.O) L.4.30 B4502 (I.O) L.4.31 B4503 (I.O)
L.4.32 B4504 (I.O) L.4.33 B4505 (I.O) L.5.1 B4506 (I.O) L.5.2 B4507
(I.O) L.5.3 B4508 (I.O) L.5.4 B4509 (I.O) L.5.5 B4510 (I.O) L.5.6
B4511 (I.O) L.5.7 B4512 (I.O) L.5.8 B4513 (I.O) L.5.9 B4514 (I.O)
L.5.10 B4515 (I.O) L.5.11 B4516 (I.O) L.5.12 B4517 (I.O) L.5.13
B4518 (I.O) L.5.14 B4519 (I.O) L.5.15 B4520 (I.O) L.5.16 B4521
(I.O) L.5.17 B4522 (I.O) L.5.18 B4523 (I.O) L.5.19
B4524 (I.O) L.5.20 B4525 (I.O) L.5.21 B4526 (I.O) L.5.22 B4527
(I.O) L.5.23 B4528 (I.O) L.5.24 B4529 (I.O) L.5.25 B4530 (I.O)
L.5.26 B4531 (I.O) L.5.27 B4532 (I.O) L.5.28 B4533 (I.O) L.5.29
B4534 (I.O) L.5.30 B4535 (I.O) L.5.31 B4536 (I.O) L.5.32 B4537
(I.O) L.5.33 B4538 (I.O) L.5.34 B4539 (I.O) L.5.35 B4540 (I.O)
L.5.36 B4541 (I.O) L.5.37 B4542 (I.O) L.5.38 B4543 (I.O) L.5.39
B4544 (I.O) L.5.40 B4545 (I.O) L.5.41 B4546 (I.O) L.5.42 B4547
(I.O) L.5.43 B4548 (I.O) L.5.44 B4549 (I.O) L.5.45 B4550 (I.O)
L.5.46 B4551 (I.O) L.5.47 B4552 (I.O) L.5.48 B4553 (I.O) L.5.49
B4554 (I.O) L.5.50 B4555 (I.O) L.5.51 B4556 (I.O) L.5.52 B4557
(I.O) L.5.53 B4558 (I.O) L.5.54 B4559 (I.O) L.5.55 B4560 (I.O)
L.5.56 B4561 (I.O) L.5.57 B4562 (I.O) L.5.58 B4563 (I.O) L.5.59
B4564 (I.O) L.5.60 B4565 (I.O) L.5.61 B4566 (I.O) L.5.62 B4567
(I.O) L.5.63 B4568 (I.O) L.5.64 B4569 (I.O) L.5.65 B4570 (I.O)
L.5.66 B4571 (I.O) L.5.67 B4572 (I.O) L.5.68 B4573 (I.O) L.5.69
B4574 (I.O) L.5.70 B4575 (I.O) L.5.71 B4576 (I.O) L.5.72 B4577
(I.O) L.5.73 B4578 (I.O) L.5.74 B4579 (I.O) L.5.75 B4580 (I.O)
L.5.76 B4581 (I.O) L.5.77 B4582 (I.O) L.5.78 B4583 (I.O) L.5.79
B4584 (I.O) L.5.80 B4585 (I.O) L.5.81 B4586 (I.O) L.5.82 B4587
(I.O) L.5.83 B4588 (I.O) L.5.84 B4589 (I.O) L.6.1 B4590 (I.O) L.6.2
B4591 (I.O) L.6.3 B4592 (I.O) L.6.4 B4593 (I.O) L.6.5 B4594 (I.O)
L.6.6 B4595 (I.O) L.6.7 B4596 (I.O) L.6.8 B4597 (I.O) L.6.9 B4598
(I.O) L.6.10 B4599 (I.O) L.6.11 B4600 (I.O) L.6.12 B4601 (I.O)
L.6.13 B4602 (I.O) L.6.14 B4603 (I.O) L.6.15 B4604 (I.O) L.6.16
B4605 (I.O) L.6.17 B4606 (I.O) L.6.18 B = Mixture; I = compound I;
II = compound II;
TABLE-US-00016 TABLE 64 B I II B4607 (I.P) L.1.1 B4608 (I.P) L.1.2
B4609 (I.P) L.1.3 B4610 (I.P) L.1.4 B4611 (I.P) L.1.5 B4612 (I.P)
L.1.6 B4613 (I.P) L.1.7 B4614 (I.P) L.1.8 B4615 (I.P) L.1.9 B4616
(I.P) L.1.10 B4617 (I.P) L.1.11 B4618 (I.P) L.1.12 B4619 (I.P)
L.1.13 B4620 (I.P) L.1.14 B4621 (I.P) L.1.15 B4622 (I.P) L.1.16
B4623 (I.P) L.1.17 B4624 (I.P) L.1.18 B4625 (I.P) L.1.19 B4626
(I.P) L.1.20 B4627 (I.P) L.1.21 B4628 (I.P) L.1.22 B4629 (I.P)
L.1.23 B4630 (I.P) L.1.24 B4631 (I.P) L.1.25 B4632 (I.P) L.1.26
B4633 (I.P) L.1.27 B4634 (I.P) L.1.28 B4635 (I.P) L.1.29 B4636
(I.P) L.1.30 B4637 (I.P) L.1.31 B4638 (I.P) L.1.32 B4639 (I.P)
L.1.33 B4640 (I.P) L.1.34 B4641 (I.P) L.1.35 B4642 (I.P) L.1.36
B4643 (I.P) L.1.37 B4644 (I.P) L.1.38 B4645 (I.P) L.1.39 B4646
(I.P) L.1.40 B4647 (I.P) L.1.41 B4648 (I.P) L.1.42 B4649 (I.P)
L.1.43 B4650 (I.P) L.1.44 B4651 (I.P) L.1.45 B4652 (I.P) L.1.46
B4653 (I.P) L.1.47 B4654 (I.P) L.1.48 B4655 (I.P) L.1.49 B4656
(I.P) L.1.50 B4657 (I.P) L.1.51 B4658 (I.P) L.1.52 B4659 (I.P)
L.1.53 B4660 (I.P) L.1.54 B4661 (I.P) L.1.55 B4662 (I.P) L.1.56
B4663 (I.P) L.1.57 B4664 (I.P) L.1.58 B4665 (I.P) L.1.59 B4666
(I.P) L.1.60 B4667 (I.P) L.1.61 B4668 (I.P) L.1.62 B4669 (I.P)
L.1.63 B4670 (I.P) L.1.64 B4671 (I.P) L.1.65 B4672 (I.P) L.1.66
B4673 (I.P) L.1.67 B4674 (I.P) L.1.68 B4675 (I.P) L.1.69 B4676
(I.P) L.1.70 B4677 (I.P) L.1.71 B4678 (I.P) L.1.72 B4679 (I.P)
L.1.73 B4680 (I.P) L.1.74 B4681 (I.P) L.1.75 B4682 (I.P) L.1.76
B4683 (I.P) L.1.77 B4684 (I.P) L.1.78 B4685 (I.P) L.1.79 B4686
(I.P) L.1.80 B4687 (I.P) L.1.81 B4688 (I.P) L.1.82 B4689 (I.P)
L.1.83 B4690 (I.P) L.1.84 B4691 (I.P) L.1.85 B4692 (I.P) L.1.86
B4693 (I.P) L.1.87 B4694 (I.P) L.1.88 B4695 (I.P) L.1.89 B4696
(I.P) L.1.90 B4697 (I.P) L.1.91 B4698 (I.P) L.1.92 B4699 (I.P)
L.1.93 B4700 (I.P) L.1.94 B4701 (I.P) L.1.95 B4702 (I.P) L.1.96
B4703 (I.P) L.2.1 B4704 (I.P) L.2.2 B4705 (I.P) L.2.3 B4706 (I.P)
L.2.4 B4707 (I.P) L.2.5 B4708 (I.P) L.2.6 B4709 (I.P) L.2.7 B4710
(I.P) L.2.8 B4711 (I.P) L.2.9 B4712 (I.P) L.2.10 B4713 (I.P) L.2.11
B4714 (I.P) L.2.12 B4715 (I.P) L.2.13 B4716 (I.P) L.2.14 B4717
(I.P) L.2.15 B4718 (I.P) L.2.16 B4719 (I.P) L.2.17 B4720 (I.P)
L.2.18 B4721 (I.P) L.2.19 B4722 (I.P) L.2.20 B4723 (I.P) L.2.21
B4724 (I.P) L.2.22 B4725 (I.P) L.2.23 B4726 (I.P) L.2.24 B4727
(I.P) L.2.25 B4728 (I.P) L.2.26 B4729 (I.P) L.2.27 B4730 (I.P)
L.2.28 B4731 (I.P) L.2.29 B4732 (I.P) L.2.30 B4733 (I.P) L.2.31
B4734 (I.P) L.2.32 B4735 (I.P) L.2.33 B4736 (I.P) L.3.1 B4737 (I.P)
L.3.2 B4738 (I.P) L.3.3 B4739 (I.P) L.3.4 B4740 (I.P) L.3.5 B4741
(I.P) L.3.6 B4742 (I.P) L.3.7 B4743 (I.P) L.3.8 B4744 (I.P) L.3.9
B4745 (I.P) L.3.10 B4746 (I.P) L.3.11 B4747 (I.P) L.3.12 B4748
(I.P) L.3.13 B4749 (I.P) L.3.14 B4750 (I.P) L.3.15 B4751 (I.P)
L.3.16 B4752 (I.P) L.3.17 B4753 (I.P) L.3.18 B4754 (I.P) L.3.19
B4755 (I.P) L.3.20 B4756 (I.P) L.3.21 B4757 (I.P) L.3.22 B4758
(I.P) L.3.23 B4759 (I.P) L.3.24 B4760 (I.P) L.3.25 B4761 (I.P)
L.3.26 B4762 (I.P) L.3.27 B4763 (I.P) L.3.28 B4764 (I.P) L.3.29
B4765 (I.P) L.3.30 B4766 (I.P) L.3.31 B4767 (I.P) L.3.32 B4768
(I.P) L.3.33 B4769 (I.P) L.3.34 B4770 (I.P) L.3.35 B4771 (I.P)
L.3.36 B4772 (I.P) L.3.37 B4773 (I.P) L.3.38 B4774 (I.P) L.3.39
B4775 (I.P) L.3.40 B4776 (I.P) L.3.41 B4777 (I.P) L.3.42 B4778
(I.P) L.3.43 B4779 (I.P) L.3.44 B4780 (I.P) L.3.45 B4781 (I.P)
L.3.46 B4782 (I.P) L.3.47 B4783 (I.P) L.3.48 B4784 (I.P) L.3.49
B4785 (I.P) L.3.50 B4786 (I.P) L.3.51 B4787 (I.P) L.3.52 B4788
(I.P) L.3.53 B4789 (I.P) L.3.54 B4790 (I.P) L.3.55 B4791 (I.P)
L.3.56 B4792 (I.P) L.3.57 B4793 (I.P) L.3.58 B4794 (I.P) L.3.59
B4795 (I.P) L.3.60 B4796 (I.P) L.3.61 B4797 (I.P) L.3.62 B4798
(I.P) L.3.63 B4799 (I.P) L.3.1 B4800 (I.P) L.3.2 B4801 (I.P) L.4.1
B4802 (I.P) L.4.2 B4803 (I.P) L.4.3 B4804 (I.P) L.4.4 B4805 (I.P)
L.4.5 B4806 (I.P) L.4.6 B4807 (I.P) L.4.7 B4808 (I.P) L.4.8 B4809
(I.P) L.4.9 B4810 (I.P) L.4.10 B4811 (I.P) L.4.11 B4812 (I.P)
L.4.12 B4813 (I.P) L.4.13 B4814 (I.P) L.4.14 B4815 (I.P) L.4.15
B4816 (I.P) L.4.16 B4817 (I.P) L.4.17 B4818 (I.P) L.4.18 B4819
(I.P) L.4.19 B4820 (I.P) L.4.20 B4821 (I.P) L.4.21 B4822 (I.P)
L.4.22 B4823 (I.P) L.4.23 B4824 (I.P) L.4.24 B4825 (I.P) L.4.25
B4826 (I.P) L.4.26 B4827 (I.P) L.4.27 B4828 (I.P) L.4.28 B4829
(I.P) L.4.29 B4830 (I.P) L.4.30 B4831 (I.P) L.4.31 B4832 (I.P)
L.4.32 B4833 (I.P) L.4.33 B4834 (I.P) L.5.1 B4835 (I.P) L.5.2 B4836
(I.P) L.5.3 B4837 (I.P) L.5.4 B4838 (I.P) L.5.5 B4839 (I.P) L.5.6
B4840 (I.P) L.5.7 B4841 (I.P) L.5.8 B4842 (I.P) L.5.9 B4843 (I.P)
L.5.10 B4844 (I.P) L.5.11 B4845 (I.P) L.5.12 B4846 (I.P) L.5.13
B4847 (I.P) L.5.14 B4848 (I.P) L.5.15 B4849 (I.P) L.5.16 B4850
(I.P) L.5.17 B4851 (I.P) L.5.18 B4852 (I.P) L.5.19
B4853 (I.P) L.5.20 B4854 (I.P) L.5.21 B4855 (I.P) L.5.22 B4856
(I.P) L.5.23 B4857 (I.P) L.5.24 B4858 (I.P) L.5.25 B4859 (I.P)
L.5.26 B4860 (I.P) L.5.27 B4861 (I.P) L.5.28 B4862 (I.P) L.5.29
B4863 (I.P) L.5.30 B4864 (I.P) L.5.31 B4865 (I.P) L.5.32 B4866
(I.P) L.5.33 B4867 (I.P) L.5.34 B4868 (I.P) L.5.35 B4869 (I.P)
L.5.36 B4870 (I.P) L.5.37 B4871 (I.P) L.5.38 B4872 (I.P) L.5.39
B4873 (I.P) L.5.40 B4874 (I.P) L.5.41 B4875 (I.P) L.5.42 B4876
(I.P) L.5.43 B4877 (I.P) L.5.44 B4878 (I.P) L.5.45 B4879 (I.P)
L.5.46 B4880 (I.P) L.5.47 B4881 (I.P) L.5.48 B4882 (I.P) L.5.49
B4883 (I.P) L.5.50 B4884 (I.P) L.5.51 B4885 (I.P) L.5.52 B4886
(I.P) L.5.53 B4887 (I.P) L.5.54 B4888 (I.P) L.5.55 B4889 (I.P)
L.5.56 B4890 (I.P) L.5.57 B4891 (I.P) L.5.58 B4892 (I.P) L.5.59
B4893 (I.P) L.5.60 B4894 (I.P) L.5.61 B4895 (I.P) L.5.62 B4896
(I.P) L.5.63 B4897 (I.P) L.5.64 B4898 (I.P) L.5.65 B4899 (I.P)
L.5.66 B4900 (I.P) L.5.67 B4901 (I.P) L.5.68 B4902 (I.P) L.5.69
B4903 (I.P) L.5.70 B4904 (I.P) L.5.71 B4905 (I.P) L.5.72 B4906
(I.P) L.5.73 B4907 (I.P) L.5.74 B4908 (I.P) L.5.75 B4909 (I.P)
L.5.76 B4910 (I.P) L.5.77 B4911 (I.P) L.5.78 B4912 (I.P) L.5.79
B4913 (I.P) L.5.80 B4914 (I.P) L.5.81 B4915 (I.P) L.5.82 B4916
(I.P) L.5.83 B4917 (I.P) L.5.84 B4918 (I.P) L.6.1 B4919 (I.P) L.6.2
B4920 (I.P) L.6.3 B4921 (I.P) L.6.4 B4922 (I.P) L.6.5 B4923 (I.P)
L.6.6 B4924 (I.P) L.6.7 B4925 (I.P) L.6.8 B4926 (I.P) L.6.9 B4927
(I.P) L.6.10 B4928 (I.P) L.6.11 B4929 (I.P) L.6.12 B4930 (I.P)
L.6.13 B4931 (I.P) L.6.14 B4932 (I.P) L.6.15 B4933 (I.P) L.6.16
B4934 (I.P) L.6.17 B4935 (I.P) L.6.18 B = Mixture; I = compound I;
II = compound II;
TABLE-US-00017 TABLE 65 B I II B4936 (I.Q) L.1.1 B4937 (I.Q) L.1.2
B4938 (I.Q) L.1.3 B4939 (I.Q) L.1.4 B4940 (I.Q) L.1.5 B4941 (I.Q)
L.1.6 B4942 (I.Q) L.1.7 B4943 (I.Q) L.1.8 B4944 (I.Q) L.1.9 B4945
(I.Q) L.1.10 B4946 (I.Q) L.1.11 B4947 (I.Q) L.1.12 B4948 (I.Q)
L.1.13 B4949 (I.Q) L.1.14 B4950 (I.Q) L.1.15 B4951 (I.Q) L.1.16
B4952 (I.Q) L.1.17 B4953 (I.Q) L.1.18 B4954 (I.Q) L.1.19 B4955
(I.Q) L.1.20 B4956 (I.Q) L.1.21 B4957 (I.Q) L.1.22 B4958 (I.Q)
L.1.23 B4959 (I.Q) L.1.24 B4960 (I.Q) L.1.25 B4961 (I.Q) L.1.26
B4962 (I.Q) L.1.27 B4963 (I.Q) L.1.28 B4964 (I.Q) L.1.29 B4965
(I.Q) L.1.30 B4966 (I.Q) L.1.31 B4967 (I.Q) L.1.32 B4968 (I.Q)
L.1.33 B4969 (I.Q) L.1.34 B4970 (I.Q) L.1.35 B4971 (I.Q) L.1.36
B4972 (I.Q) L.1.37 B4973 (I.Q) L.1.38 B4974 (I.Q) L.1.39 B4975
(I.Q) L.1.40 B4976 (I.Q) L.1.41 B4977 (I.Q) L.1.42 B4978 (I.Q)
L.1.43 B4979 (I.Q) L.1.44 B4980 (I.Q) L.1.45 B4981 (I.Q) L.1.46
B4982 (I.Q) L.1.47 B4983 (I.Q) L.1.48 B4984 (I.Q) L.1.49 B4985
(I.Q) L.1.50 B4986 (I.Q) L.1.51 B4987 (I.Q) L.1.52 B4988 (I.Q)
L.1.53 B4989 (I.Q) L.1.54 B4990 (I.Q) L.1.55 B4991 (I.Q) L.1.56
B4992 (I.Q) L.1.57 B4993 (I.Q) L.1.58 B4994 (I.Q) L.1.59 B4995
(I.Q) L.1.60 B4996 (I.Q) L.1.61 B4997 (I.Q) L.1.62 B4998 (I.Q)
L.1.63 B4999 (I.Q) L.1.64 B5000 (I.Q) L.1.65 B5001 (I.Q) L.1.66
B5002 (I.Q) L.1.67 B5003 (I.Q) L.1.68 B5004 (I.Q) L.1.69 B5005
(I.Q) L.1.70 B5006 (I.Q) L.1.71 B5007 (I.Q) L.1.72 B5008 (I.Q)
L.1.73 B5009 (I.Q) L.1.74 B5010 (I.Q) L.1.75 B5011 (I.Q) L.1.76
B5012 (I.Q) L.1.77 B5013 (I.Q) L.1.78 B5014 (I.Q) L.1.79 B5015
(I.Q) L.1.80 B5016 (I.Q) L.1.81 B5017 (I.Q) L.1.82 B5018 (I.Q)
L.1.83 B5019 (I.Q) L.1.84 B5020 (I.Q) L.1.85 B5021 (I.Q) L.1.86
B5022 (I.Q) L.1.87 B5023 (I.Q) L.1.88 B5024 (I.Q) L.1.89 B5025
(I.Q) L.1.90 B5026 (I.Q) L.1.91 B5027 (I.Q) L.1.92 B5028 (I.Q)
L.1.93 B5029 (I.Q) L.1.94 B5030 (I.Q) L.1.95 B5031 (I.Q) L.1.96
B5032 (I.Q) L.2.1 B5033 (I.Q) L.2.2 B5034 (I.Q) L.2.3 B5035 (I.Q)
L.2.4 B5036 (I.Q) L.2.5 B5037 (I.Q) L.2.6 B5038 (I.Q) L.2.7 B5039
(I.Q) L.2.8 B5040 (I.Q) L.2.9 B5041 (I.Q) L.2.10 B5042 (I.Q) L.2.11
B5043 (I.Q) L.2.12 B5044 (I.Q) L.2.13 B5045 (I.Q) L.2.14 B5046
(I.Q) L.2.15 B5047 (I.Q) L.2.16 B5048 (I.Q) L.2.17 B5049 (I.Q)
L.2.18 B5050 (I.Q) L.2.19 B5051 (I.Q) L.2.20 B5052 (I.Q) L.2.21
B5053 (I.Q) L.2.22 B5054 (I.Q) L.2.23 B5055 (I.Q) L.2.24 B5056
(I.Q) L.2.25 B5057 (I.Q) L.2.26 B5058 (I.Q) L.2.27 B5059 (I.Q)
L.2.28 B5060 (I.Q) L.2.29 B5061 (I.Q) L.2.30 B5062 (I.Q) L.2.31
B5063 (I.Q) L.2.32 B5064 (I.Q) L.2.33 B5065 (I.Q) L.3.1 B5066 (I.Q)
L.3.2 B5067 (I.Q) L.3.3 B5068 (I.Q) L.3.4 B5069 (I.Q) L.3.5 B5070
(I.Q) L.3.6 B5071 (I.Q) L.3.7 B5072 (I.Q) L.3.8 B5073 (I.Q) L.3.9
B5074 (I.Q) L.3.10 B5075 (I.Q) L.3.11 B5076 (I.Q) L.3.12 B5077
(I.Q) L.3.13 B5078 (I.Q) L.3.14 B5079 (I.Q) L.3.15 B5080 (I.Q)
L.3.16 B5081 (I.Q) L.3.17 B5082 (I.Q) L.3.18 B5083 (I.Q) L.3.19
B5084 (I.Q) L.3.20 B5085 (I.Q) L.3.21 B5086 (I.Q) L.3.22 B5087
(I.Q) L.3.23 B5088 (I.Q) L.3.24 B5089 (I.Q) L.3.25 B5090 (I.Q)
L.3.26 B5091 (I.Q) L.3.27 B5092 (I.Q) L.3.28 B5093 (I.Q) L.3.29
B5094 (I.Q) L.3.30 B5095 (I.Q) L.3.31 B5096 (I.Q) L.3.32 B5097
(I.Q) L.3.33 B5098 (I.Q) L.3.34 B5099 (I.Q) L.3.35 B5100 (I.Q)
L.3.36 B5101 (I.Q) L.3.37 B5102 (I.Q) L.3.38 B5103 (I.Q) L.3.39
B5104 (I.Q) L.3.40 B5105 (I.Q) L.3.41 B5106 (I.Q) L.3.42 B5107
(I.Q) L.3.43 B5108 (I.Q) L.3.44 B5109 (I.Q) L.3.45 B5110 (I.Q)
L.3.46 B5111 (I.Q) L.3.47 B5112 (I.Q) L.3.48 B5113 (I.Q) L.3.49
B5114 (I.Q) L.3.50 B5115 (I.Q) L.3.51 B5116 (I.Q) L.3.52 B5117
(I.Q) L.3.53 B5118 (I.Q) L.3.54 B5119 (I.Q) L.3.55 B5120 (I.Q)
L.3.56 B5121 (I.Q) L.3.57 B5122 (I.Q) L.3.58 B5123 (I.Q) L.3.59
B5124 (I.Q) L.3.60 B5125 (I.Q) L.3.61 B5126 (I.Q) L.3.62 B5127
(I.Q) L.3.63 B5128 (I.Q) L.3.1 B5129 (I.Q) L.3.2 B5130 (I.Q) L.4.1
B5131 (I.Q) L.4.2 B5132 (I.Q) L.4.3 B5133 (I.Q) L.4.4 B5134 (I.Q)
L.4.5 B5135 (I.Q) L.4.6 B5136 (I.Q) L.4.7 B5137 (I.Q) L.4.8 B5138
(I.Q) L.4.9 B5139 (I.Q) L.4.10 B5140 (I.Q) L.4.11 B5141 (I.Q)
L.4.12 B5142 (I.Q) L.4.13 B5143 (I.Q) L.4.14 B5144 (I.Q) L.4.15
B5145 (I.Q) L.4.16 B5146 (I.Q) L.4.17 B5147 (I.Q) L.4.18 B5148
(I.Q) L.4.19 B5149 (I.Q) L.4.20 B5150 (I.Q) L.4.21 B5151 (I.Q)
L.4.22 B5152 (I.Q) L.4.23 B5153 (I.Q) L.4.24 B5154 (I.Q) L.4.25
B5155 (I.Q) L.4.26 B5156 (I.Q) L.4.27 B5157 (I.Q) L.4.28 B5158
(I.Q) L.4.29 B5159 (I.Q) L.4.30 B5160 (I.Q) L.4.31 B5161 (I.Q)
L.4.32 B5162 (I.Q) L.4.33 B5163 (I.Q) L.5.1 B5164 (I.Q) L.5.2 B5165
(I.Q) L.5.3 B5166 (I.Q) L.5.4 B5167 (I.Q) L.5.5 B5168 (I.Q) L.5.6
B5169 (I.Q) L.5.7 B5170 (I.Q) L.5.8 B5171 (I.Q) L.5.9 B5172 (I.Q)
L.5.10 B5173 (I.Q) L.5.11 B5174 (I.Q) L.5.12 B5175 (I.Q) L.5.13
B5176 (I.Q) L.5.14 B5177 (I.Q) L.5.15 B5178 (I.Q) L.5.16 B5179
(I.Q) L.5.17 B5180 (I.Q) L.5.18 B5181 (I.Q) L.5.19
B5182 (I.Q) L.5.20 B5183 (I.Q) L.5.21 B5184 (I.Q) L.5.22 B5185
(I.Q) L.5.23 B5186 (I.Q) L.5.24 B5187 (I.Q) L.5.25 B5188 (I.Q)
L.5.26 B5189 (I.Q) L.5.27 B5190 (I.Q) L.5.28 B5191 (I.Q) L.5.29
B5192 (I.Q) L.5.30 B5193 (I.Q) L.5.31 B5194 (I.Q) L.5.32 B5195
(I.Q) L.5.33 B5196 (I.Q) L.5.34 B5197 (I.Q) L.5.35 B5198 (I.Q)
L.5.36 B5199 (I.Q) L.5.37 B5200 (I.Q) L.5.38 B5201 (I.Q) L.5.39
B5202 (I.Q) L.5.40 B5203 (I.Q) L.5.41 B5204 (I.Q) L.5.42 B5205
(I.Q) L.5.43 B5206 (I.Q) L.5.44 B5207 (I.Q) L.5.45 B5208 (I.Q)
L.5.46 B5209 (I.Q) L.5.47 B5210 (I.Q) L.5.48 B5211 (I.Q) L.5.49
B5212 (I.Q) L.5.50 B5213 (I.Q) L.5.51 B5214 (I.Q) L.5.52 B5215
(I.Q) L.5.53 B5216 (I.Q) L.5.54 B5217 (I.Q) L.5.55 B5218 (I.Q)
L.5.56 B5219 (I.Q) L.5.57 B5220 (I.Q) L.5.58 B5221 (I.Q) L.5.59
B5222 (I.Q) L.5.60 B5223 (I.Q) L.5.61 B5224 (I.Q) L.5.62 B5225
(I.Q) L.5.63 B5226 (I.Q) L.5.64 B5227 (I.Q) L.5.65 B5228 (I.Q)
L.5.66 B5229 (I.Q) L.5.67 B5230 (I.Q) L.5.68 B5231 (I.Q) L.5.69
B5232 (I.Q) L.5.70 B5233 (I.Q) L.5.71 B5234 (I.Q) L.5.72 B5235
(I.Q) L.5.73 B5236 (I.Q) L.5.74 B5237 (I.Q) L.5.75 B5238 (I.Q)
L.5.76 B5239 (I.Q) L.5.77 B5240 (I.Q) L.5.78 B5241 (I.Q) L.5.79
B5242 (I.Q) L.5.80 B5243 (I.Q) L.5.81 B5244 (I.Q) L.5.82 B5245
(I.Q) L.5.83 B5246 (I.Q) L.5.84 B5247 (I.Q) L.6.1 B5248 (I.Q) L.6.2
B5249 (I.Q) L.6.3 B5250 (I.Q) L.6.4 B5251 (I.Q) L.6.5 B5252 (I.Q)
L.6.6 B5253 (I.Q) L.6.7 B5254 (I.Q) L.6.8 B5255 (I.Q) L.6.9 B5256
(I.Q) L.6.10 B5257 (I.Q) L.6.11 B5258 (I.Q) L.6.12 B5259 (I.Q)
L.6.13 B5260 (I.Q) L.6.14 B5261 (I.Q) L.6.15 B5262 (I.Q) L.6.16
B5263 (I.Q) L.6.17 B5264 (I.Q) L.6.18 B = Mixture; I = compound I;
II = compound II;
TABLE-US-00018 TABLE 66 B I II B5265 (I.R) L.1.1 B5266 (I.R) L.1.2
B5267 (I.R) L.1.3 B5268 (I.R) L.1.4 B5269 (I.R) L.1.5 B5270 (I.R)
L.1.6 B5271 (I.R) L.1.7 B5272 (I.R) L.1.8 B5273 (I.R) L.1.9 B5274
(I.R) L.1.10 B5275 (I.R) L.1.11 B5276 (I.R) L.1.12 B5277 (I.R)
L.1.13 B5278 (I.R) L.1.14 B5279 (I.R) L.1.15 B5280 (I.R) L.1.16
B5281 (I.R) L.1.17 B5282 (I.R) L.1.18 B5283 (I.R) L.1.19 B5284
(I.R) L.1.20 B5285 (I.R) L.1.21 B5286 (I.R) L.1.22 B5287 (I.R)
L.1.23 B5288 (I.R) L.1.24 B5289 (I.R) L.1.25 B5290 (I.R) L.1.26
B5291 (I.R) L.1.27 B5292 (I.R) L.1.28 B5293 (I.R) L.1.29 B5294
(I.R) L.1.30 B5295 (I.R) L.1.31 B5296 (I.R) L.1.32 B5297 (I.R)
L.1.33 B5298 (I.R) L.1.34 B5299 (I.R) L.1.35 B5300 (I.R) L.1.36
B5301 (I.R) L.1.37 B5302 (I.R) L.1.38 B5303 (I.R) L.1.39 B5304
(I.R) L.1.40 B5305 (I.R) L.1.41 B5306 (I.R) L.1.42 B5307 (I.R)
L.1.43 B5308 (I.R) L.1.44 B5309 (I.R) L.1.45 B5310 (I.R) L.1.46
B5311 (I.R) L.1.47 B5312 (I.R) L.1.48 B5313 (I.R) L.1.49 B5314
(I.R) L.1.50 B5315 (I.R) L.1.51 B5316 (I.R) L.1.52 B5317 (I.R)
L.1.53 B5318 (I.R) L.1.54 B5319 (I.R) L.1.55 B5320 (I.R) L.1.56
B5321 (I.R) L.1.57 B5322 (I.R) L.1.58 B5323 (I.R) L.1.59 B5324
(I.R) L.1.60 B5325 (I.R) L.1.61 B5326 (I.R) L.1.62 B5327 (I.R)
L.1.63 B5328 (I.R) L.1.64 B5329 (I.R) L.1.65 B5330 (I.R) L.1.66
B5331 (I.R) L.1.67 B5332 (I.R) L.1.68 B5333 (I.R) L.1.69 B5334
(I.R) L.1.70 B5335 (I.R) L.1.71 B5336 (I.R) L.1.72 B5337 (I.R)
L.1.73 B5338 (I.R) L.1.74 B5339 (I.R) L.1.75 B5340 (I.R) L.1.76
B5341 (I.R) L.1.77 B5342 (I.R) L.1.78 B5343 (I.R) L.1.79 B5344
(I.R) L.1.80 B5345 (I.R) L.1.81 B5346 (I.R) L.1.82 B5347 (I.R)
L.1.83 B5348 (I.R) L.1.84 B5349 (I.R) L.1.85 B5350 (I.R) L.1.86
B5351 (I.R) L.1.87 B5352 (I.R) L.1.88 B5353 (I.R) L.1.89 B5354
(I.R) L.1.90 B5355 (I.R) L.1.91 B5356 (I.R) L.1.92 B5357 (I.R)
L.1.93 B5358 (I.R) L.1.94 B5359 (I.R) L.1.95 B5360 (I.R) L.1.96
B5361 (I.R) L.2.1 B5362 (I.R) L.2.2 B5363 (I.R) L.2.3 B5364 (I.R)
L.2.4 B5365 (I.R) L.2.5 B5366 (I.R) L.2.6 B5367 (I.R) L.2.7 B5368
(I.R) L.2.8 B5369 (I.R) L.2.9 B5370 (I.R) L.2.10 B5371 (I.R) L.2.11
B5372 (I.R) L.2.12 B5373 (I.R) L.2.13 B5374 (I.R) L.2.14 B5375
(I.R) L.2.15 B5376 (I.R) L.2.16 B5377 (I.R) L.2.17 B5378 (I.R)
L.2.18 B5379 (I.R) L.2.19 B5380 (I.R) L.2.20 B5381 (I.R) L.2.21
B5382 (I.R) L.2.22 B5383 (I.R) L.2.23 B5384 (I.R) L.2.24 B5385
(I.R) L.2.25 B5386 (I.R) L.2.26 B5387 (I.R) L.2.27 B5388 (I.R)
L.2.28 B5389 (I.R) L.2.29 B5390 (I.R) L.2.30 B5391 (I.R) L.2.31
B5392 (I.R) L.2.32 B5393 (I.R) L.2.33 B5394 (I.R) L.3.1 B5395 (I.R)
L.3.2 B5396 (I.R) L.3.3 B5397 (I.R) L.3.4 B5398 (I.R) L.3.5 B5399
(I.R) L.3.6 B5400 (I.R) L.3.7 B5401 (I.R) L.3.8 B5402 (I.R) L.3.9
B5403 (I.R) L.3.10 B5404 (I.R) L.3.11 B5405 (I.R) L.3.12 B5406
(I.R) L.3.13 B5407 (I.R) L.3.14 B5408 (I.R) L.3.15 B5409 (I.R)
L.3.16 B5410 (I.R) L.3.17 B5411 (I.R) L.3.18 B5412 (I.R) L.3.19
B5413 (I.R) L.3.20 B5414 (I.R) L.3.21 B5415 (I.R) L.3.22 B5416
(I.R) L.3.23 B5417 (I.R) L.3.24 B5418 (I.R) L.3.25 B5419 (I.R)
L.3.26 B5420 (I.R) L.3.27 B5421 (I.R) L.3.28 B5422 (I.R) L.3.29
B5423 (I.R) L.3.30 B5424 (I.R) L.3.31 B5425 (I.R) L.3.32 B5426
(I.R) L.3.33 B5427 (I.R) L.3.34 B5428 (I.R) L.3.35 B5429 (I.R)
L.3.36 B5430 (I.R) L.3.37 B5431 (I.R) L.3.38 B5432 (I.R) L.3.39
B5433 (I.R) L.3.40 B5434 (I.R) L.3.41 B5435 (I.R) L.3.42 B5436
(I.R) L.3.43 B5437 (I.R) L.3.44 B5438 (I.R) L.3.45 B5439 (I.R)
L.3.46 B5440 (I.R) L.3.47 B5441 (I.R) L.3.48 B5442 (I.R) L.3.49
B5443 (I.R) L.3.50 B5444 (I.R) L.3.51 B5445 (I.R) L.3.52 B5446
(I.R) L.3.53 B5447 (I.R) L.3.54 B5448 (I.R) L.3.55 B5449 (I.R)
L.3.56 B5450 (I.R) L.3.57 B5451 (I.R) L.3.58 B5452 (I.R) L.3.59
B5453 (I.R) L.3.60 B5454 (I.R) L.3.61 B5455 (I.R) L.3.62 B5456
(I.R) L.3.63 B5457 (I.R) L.3.1 B5458 (I.R) L.3.2 B5459 (I.R) L.4.1
B5460 (I.R) L.4.2 B5461 (I.R) L.4.3 B5462 (I.R) L.4.4 B5463 (I.R)
L.4.5 B5464 (I.R) L.4.6 B5465 (I.R) L.4.7 B5466 (I.R) L.4.8 B5467
(I.R) L.4.9 B5468 (I.R) L.4.10 B5469 (I.R) L.4.11 B5470 (I.R)
L.4.12 B5471 (I.R) L.4.13 B5472 (I.R) L.4.14 B5473 (I.R) L.4.15
B5474 (I.R) L.4.16 B5475 (I.R) L.4.17 B5476 (I.R) L.4.18 B5477
(I.R) L.4.19 B5478 (I.R) L.4.20 B5479 (I.R) L.4.21 B5480 (I.R)
L.4.22 B5481 (I.R) L.4.23 B5482 (I.R) L.4.24 B5483 (I.R) L.4.25
B5484 (I.R) L.4.26 B5485 (I.R) L.4.27 B5486 (I.R) L.4.28 B5487
(I.R) L.4.29 B5488 (I.R) L.4.30 B5489 (I.R) L.4.31 B5490 (I.R)
L.4.32 B5491 (I.R) L.4.33 B5492 (I.R) L.5.1 B5493 (I.R) L.5.2 B5494
(I.R) L.5.3 B5495 (I.R) L.5.4 B5496 (I.R) L.5.5 B5497 (I.R) L.5.6
B5498 (I.R) L.5.7 B5499 (I.R) L.5.8 B5500 (I.R) L.5.9 B5501 (I.R)
L.5.10 B5502 (I.R) L.5.11 B5503 (I.R) L.5.12 B5504 (I.R) L.5.13
B5505 (I.R) L.5.14 B5506 (I.R) L.5.15 B5507 (I.R) L.5.16 B5508
(I.R) L.5.17 B5509 (I.R) L.5.18 B5510 (I.R) L.5.19
B5511 (I.R) L.5.20 B5512 (I.R) L.5.21 B5513 (I.R) L.5.22 B5514
(I.R) L.5.23 B5515 (I.R) L.5.24 B5516 (I.R) L.5.25 B5517 (I.R)
L.5.26 B5518 (I.R) L.5.27 B5519 (I.R) L.5.28 B5520 (I.R) L.5.29
B5521 (I.R) L.5.30 B5522 (I.R) L.5.31 B5523 (I.R) L.5.32 B5524
(I.R) L.5.33 B5525 (I.R) L.5.34 B5526 (I.R) L.5.35 B5527 (I.R)
L.5.36 B5528 (I.R) L.5.37 B5529 (I.R) L.5.38 B5530 (I.R) L.5.39
B5531 (I.R) L.5.40 B5532 (I.R) L.5.41 B5533 (I.R) L.5.42 B5534
(I.R) L.5.43 B5535 (I.R) L.5.44 B5536 (I.R) L.5.45 B5537 (I.R)
L.5.46 B5538 (I.R) L.5.47 B5539 (I.R) L.5.48 B5540 (I.R) L.5.49
B5541 (I.R) L.5.50 B5542 (I.R) L.5.51 B5543 (I.R) L.5.52 B5544
(I.R) L.5.53 B5545 (I.R) L.5.54 B5546 (I.R) L.5.55 B5547 (I.R)
L.5.56 B5548 (I.R) L.5.57 B5549 (I.R) L.5.58 B5550 (I.R) L.5.59
B5551 (I.R) L.5.60 B5552 (I.R) L.5.61 B5553 (I.R) L.5.62 B5554
(I.R) L.5.63 B5555 (I.R) L.5.64 B5556 (I.R) L.5.65 B5557 (I.R)
L.5.66 B5558 (I.R) L.5.67 B5559 (I.R) L.5.68 B5560 (I.R) L.5.69
B5561 (I.R) L.5.70 B5562 (I.R) L.5.71 B5563 (I.R) L.5.72 B5564
(I.R) L.5.73 B5565 (I.R) L.5.74 B5566 (I.R) L.5.75 B5567 (I.R)
L.5.76 B5568 (I.R) L.5.77 B5569 (I.R) L.5.78 B5570 (I.R) L.5.79
B5571 (I.R) L.5.80 B5572 (I.R) L.5.81 B5573 (I.R) L.5.82 B5574
(I.R) L.5.83 B5575 (I.R) L.5.84 B5576 (I.R) L.6.1 B5577 (I.R) L.6.2
B5578 (I.R) L.6.3 B5579 (I.R) L.6.4 B5580 (I.R) L.6.5 B5581 (I.R)
L.6.6 B5582 (I.R) L.6.7 B5583 (I.R) L.6.8 B5584 (I.R) L.6.9 B5585
(I.R) L.6.10 B5586 (I.R) L.6.11 B5587 (I.R) L.6.12 B5588 (I.R)
L.6.13 B5589 (I.R) L.6.14 B5590 (I.R) L.6.15 B5591 (I.R) L.6.16
B5592 (I.R) L.6.17 B5593 (I.R) L.6.18 B = Mixture; I = compound I;
II = compound II;
TABLE-US-00019 TABLE 67 B I II B5594 (I.S) L.1.1 B5595 (I.S) L.1.2
B5596 (I.S) L.1.3 B5597 (I.S) L.1.4 B5598 (I.S) L.1.5 B5599 (I.S)
L.1.6 B5600 (I.S) L.1.7 B5601 (I.S) L.1.8 B5602 (I.S) L.1.9 B5603
(I.S) L.1.10 B5604 (I.S) L.1.11 B5605 (I.S) L.1.12 B5606 (I.S)
L.1.13 B5607 (I.S) L.1.14 B5608 (I.S) L.1.15 B5609 (I.S) L.1.16
B5610 (I.S) L.1.17 B5611 (I.S) L.1.18 B5612 (I.S) L.1.19 B5613
(I.S) L.1.20 B5614 (I.S) L.1.21 B5615 (I.S) L.1.22 B5616 (I.S)
L.1.23 B5617 (I.S) L.1.24 B5618 (I.S) L.1.25 B5619 (I.S) L.1.26
B5620 (I.S) L.1.27 B5621 (I.S) L.1.28 B5622 (I.S) L.1.29 B5623
(I.S) L.1.30 B5624 (I.S) L.1.31 B5625 (I.S) L.1.32 B5626 (I.S)
L.1.33 B5627 (I.S) L.1.34 B5628 (I.S) L.1.35 B5629 (I.S) L.1.36
B5630 (I.S) L.1.37 B5631 (I.S) L.1.38 B5632 (I.S) L.1.39 B5633
(I.S) L.1.40 B5634 (I.S) L.1.41 B5635 (I.S) L.1.42 B5636 (I.S)
L.1.43 B5637 (I.S) L.1.44 B5638 (I.S) L.1.45 B5639 (I.S) L.1.46
B5640 (I.S) L.1.47 B5641 (I.S) L.1.48 B5642 (I.S) L.1.49 B5643
(I.S) L.1.50 B5644 (I.S) L.1.51 B5645 (I.S) L.1.52 B5646 (I.S)
L.1.53 B5647 (I.S) L.1.54 B5648 (I.S) L.1.55 B5649 (I.S) L.1.56
B5650 (I.S) L.1.57 B5651 (I.S) L.1.58 B5652 (I.S) L.1.59 B5653
(I.S) L.1.60 B5654 (I.S) L.1.61 B5655 (I.S) L.1.62 B5656 (I.S)
L.1.63 B5657 (I.S) L.1.64 B5658 (I.S) L.1.65 B5659 (I.S) L.1.66
B5660 (I.S) L.1.67 B5661 (I.S) L.1.68 B5662 (I.S) L.1.69 B5663
(I.S) L.1.70 B5664 (I.S) L.1.71 B5665 (I.S) L.1.72 B5666 (I.S)
L.1.73 B5667 (I.S) L.1.74 B5668 (I.S) L.1.75 B5669 (I.S) L.1.76
B5670 (I.S) L.1.77 B5671 (I.S) L.1.78 B5672 (I.S) L.1.79 B5673
(I.S) L.1.80 B5674 (I.S) L.1.81 B5675 (I.S) L.1.82 B5676 (I.S)
L.1.83 B5677 (I.S) L.1.84 B5678 (I.S) L.1.85 B5679 (I.S) L.1.86
B5680 (I.S) L.1.87 B5681 (I.S) L.1.88 B5682 (I.S) L.1.89 B5683
(I.S) L.1.90 B5684 (I.S) L.1.91 B5685 (I.S) L.1.92 B5686 (I.S)
L.1.93 B5687 (I.S) L.1.94 B5688 (I.S) L.1.95 B5689 (I.S) L.1.96
B5690 (I.S) L.2.1 B5691 (I.S) L.2.2 B5692 (I.S) L.2.3 B5693 (I.S)
L.2.4 B5694 (I.S) L.2.5 B5695 (I.S) L.2.6 B5696 (I.S) L.2.7 B5697
(I.S) L.2.8 B5698 (I.S) L.2.9 B5699 (I.S) L.2.10 B5700 (I.S) L.2.11
B5701 (I.S) L.2.12 B5702 (I.S) L.2.13 B5703 (I.S) L.2.14 B5704
(I.S) L.2.15 B5705 (I.S) L.2.16 B5706 (I.S) L.2.17 B5707 (I.S)
L.2.18 B5708 (I.S) L.2.19 B5709 (I.S) L.2.20 B5710 (I.S) L.2.21
B5711 (I.S) L.2.22 B5712 (I.S) L.2.23 B5713 (I.S) L.2.24 B5714
(I.S) L.2.25 B5715 (I.S) L.2.26 B5716 (I.S) L.2.27 B5717 (I.S)
L.2.28 B5718 (I.S) L.2.29 B5719 (I.S) L.2.30 B5720 (I.S) L.2.31
B5721 (I.S) L.2.32 B5722 (I.S) L.2.33 B5723 (I.S) L.3.1 B5724 (I.S)
L.3.2 B5725 (I.S) L.3.3 B5726 (I.S) L.3.4 B5727 (I.S) L.3.5 B5728
(I.S) L.3.6 B5729 (I.S) L.3.7 B5730 (I.S) L.3.8 B5731 (I.S) L.3.9
B5732 (I.S) L.3.10 B5733 (I.S) L.3.11 B5734 (I.S) L.3.12 B5735
(I.S) L.3.13 B5736 (I.S) L.3.14 B5737 (I.S) L.3.15 B5738 (I.S)
L.3.16 B5739 (I.S) L.3.17 B5740 (I.S) L.3.18 B5741 (I.S) L.3.19
B5742 (I.S) L.3.20 B5743 (I.S) L.3.21 B5744 (I.S) L.3.22 B5745
(I.S) L.3.23 B5746 (I.S) L.3.24 B5747 (I.S) L.3.25 B5748 (I.S)
L.3.26 B5749 (I.S) L.3.27 B5750 (I.S) L.3.28 B5751 (I.S) L.3.29
B5752 (I.S) L.3.30 B5753 (I.S) L.3.31 B5754 (I.S) L.3.32 B5755
(I.S) L.3.33 B5756 (I.S) L.3.34 B5757 (I.S) L.3.35 B5758 (I.S)
L.3.36 B5759 (I.S) L.3.37 B5760 (I.S) L.3.38 B5761 (I.S) L.3.39
B5762 (I.S) L.3.40 B5763 (I.S) L.3.41 B5764 (I.S) L.3.42 B5765
(I.S) L.3.43 B5766 (I.S) L.3.44 B5767 (I.S) L.3.45 B5768 (I.S)
L.3.46 B5769 (I.S) L.3.47 B5770 (I.S) L.3.48 B5771 (I.S) L.3.49
B5772 (I.S) L.3.50 B5773 (I.S) L.3.51 B5774 (I.S) L.3.52 B5775
(I.S) L.3.53 B5776 (I.S) L.3.54 B5777 (I.S) L.3.55 B5778 (I.S)
L.3.56 B5779 (I.S) L.3.57 B5780 (I.S) L.3.58 B5781 (I.S) L.3.59
B5782 (I.S) L.3.60 B5783 (I.S) L.3.61 B5784 (I.S) L.3.62 B5785
(I.S) L.3.63 B5786 (I.S) L.3.1 B5787 (I.S) L.3.2 B5788 (I.S) L.4.1
B5789 (I.S) L.4.2 B5790 (I.S) L.4.3 B5791 (I.S) L.4.4 B5792 (I.S)
L.4.5 B5793 (I.S) L.4.6 B5794 (I.S) L.4.7 B5795 (I.S) L.4.8 B5796
(I.S) L.4.9 B5797 (I.S) L.4.10 B5798 (I.S) L.4.11 B5799 (I.S)
L.4.12 B5800 (I.S) L.4.13 B5801 (I.S) L.4.14 B5802 (I.S) L.4.15
B5803 (I.S) L.4.16 B5804 (I.S) L.4.17 B5805 (I.S) L.4.18 B5806
(I.S) L.4.19 B5807 (I.S) L.4.20 B5808 (I.S) L.4.21 B5809 (I.S)
L.4.22 B5810 (I.S) L.4.23 B5811 (I.S) L.4.24 B5812 (I.S) L.4.25
B5813 (I.S) L.4.26 B5814 (I.S) L.4.27 B5815 (I.S) L.4.28 B5816
(I.S) L.4.29 B5817 (I.S) L.4.30 B5818 (I.S) L.4.31 B5819 (I.S)
L.4.32 B5820 (I.S) L.4.33 B5821 (I.S) L.5.1 B5822 (I.S) L.5.2 B5823
(I.S) L.5.3 B5824 (I.S) L.5.4 B5825 (I.S) L.5.5 B5826 (I.S) L.5.6
B5827 (I.S) L.5.7 B5828 (I.S) L.5.8 B5829 (I.S) L.5.9 B5830 (I.S)
L.5.10 B5831 (I.S) L.5.11 B5832 (I.S) L.5.12 B5833 (I.S) L.5.13
B5834 (I.S) L.5.14 B5835 (I.S) L.5.15 B5836 (I.S) L.5.16 B5837
(I.S) L.5.17 B5838 (I.S) L.5.18 B5839 (I.S) L.5.19
B5840 (I.S) L.5.20 B5841 (I.S) L.5.21 B5842 (I.S) L.5.22 B5843
(I.S) L.5.23 B5844 (I.S) L.5.24 B5845 (I.S) L.5.25 B5846 (I.S)
L.5.26 B5847 (I.S) L.5.27 B5848 (I.S) L.5.28 B5849 (I.S) L.5.29
B5850 (I.S) L.5.30 B5851 (I.S) L.5.31 B5852 (I.S) L.5.32 B5853
(I.S) L.5.33 B5854 (I.S) L.5.34 B5855 (I.S) L.5.35 B5856 (I.S)
L.5.36 B5857 (I.S) L.5.37 B5858 (I.S) L.5.38 B5859 (I.S) L.5.39
B5860 (I.S) L.5.40 B5861 (I.S) L.5.41 B5862 (I.S) L.5.42 B5863
(I.S) L.5.43 B5864 (I.S) L.5.44 B5865 (I.S) L.5.45 B5866 (I.S)
L.5.46 B5867 (I.S) L.5.47 B5868 (I.S) L.5.48 B5869 (I.S) L.5.49
B5870 (I.S) L.5.50 B5871 (I.S) L.5.51 B5872 (I.S) L.5.52 B5873
(I.S) L.5.53 B5874 (I.S) L.5.54 B5875 (I.S) L.5.55 B5876 (I.S)
L.5.56 B5877 (I.S) L.5.57 B5878 (I.S) L.5.58 B5879 (I.S) L.5.59
B5880 (I.S) L.5.60 B5881 (I.S) L.5.61 B5882 (I.S) L.5.62 B5883
(I.S) L.5.63 B5884 (I.S) L.5.64 B5885 (I.S) L.5.65 B5886 (I.S)
L.5.66 B5887 (I.S) L.5.67 B5888 (I.S) L.5.68 B5889 (I.S) L.5.69
B5890 (I.S) L.5.70 B5891 (I.S) L.5.71 B5892 (I.S) L.5.72 B5893
(I.S) L.5.73 B5894 (I.S) L.5.74 B5895 (I.S) L.5.75 B5896 (I.S)
L.5.76 B5897 (I.S) L.5.77 B5898 (I.S) L.5.78 B5899 (I.S) L.5.79
B5900 (I.S) L.5.80 B5901 (I.S) L.5.81 B5902 (I.S) L.5.82 B5903
(I.S) L.5.83 B5904 (I.S) L.5.84 B5905 (I.S) L.6.1 B5906 (I.S) L.6.2
B5907 (I.S) L.6.3 B5908 (I.S) L.6.4 B5909 (I.S) L.6.5 B5910 (I.S)
L.6.6 B5911 (I.S) L.6.7 B5912 (I.S) L.6.8 B5913 (I.S) L.6.9 B5914
(I.S) L.6.10 B5915 (I.S) L.6.11 B5916 (I.S) L.6.12 B5917 (I.S)
L.6.13 B5918 (I.S) L.6.14 B5919 (I.S) L.6.15 B5920 (I.S) L.6.16
B5921 (I.S) L.6.17 B5922 (I.S) L.6.18 B = Mixture; I = compound I;
II = compound II;
TABLE-US-00020 TABLE 68 B I II B5923 (I.T) L.1.1 B5924 (I.T) L.1.2
B5925 (I.T) L.1.3 B5926 (I.T) L.1.4 B5927 (I.T) L.1.5 B5928 (I.T)
L.1.6 B5929 (I.T) L.1.7 B5930 (I.T) L.1.8 B5931 (I.T) L.1.9 B5932
(I.T) L.1.10 B5933 (I.T) L.1.11 B5934 (I.T) L.1.12 B5935 (I.T)
L.1.13 B5936 (I.T) L.1.14 B5937 (I.T) L.1.15 B5938 (I.T) L.1.16
B5939 (I.T) L.1.17 B5940 (I.T) L.1.18 B5941 (I.T) L.1.19 B5942
(I.T) L.1.20 B5943 (I.T) L.1.21 B5944 (I.T) L.1.22 B5945 (I.T)
L.1.23 B5946 (I.T) L.1.24 B5947 (I.T) L.1.25 B5948 (I.T) L.1.26
B5949 (I.T) L.1.27 B5950 (I.T) L.1.28 B5951 (I.T) L.1.29 B5952
(I.T) L.1.30 B5953 (I.T) L.1.31 B5954 (I.T) L.1.32 B5955 (I.T)
L.1.33 B5956 (I.T) L.1.34 B5957 (I.T) L.1.35 B5958 (I.T) L.1.36
B5959 (I.T) L.1.37 B5960 (I.T) L.1.38 B5961 (I.T) L.1.39 B5962
(I.T) L.1.40 B5963 (I.T) L.1.41 B5964 (I.T) L.1.42 B5965 (I.T)
L.1.43 B5966 (I.T) L.1.44 B5967 (I.T) L.1.45 B5968 (I.T) L.1.46
B5969 (I.T) L.1.47 B5970 (I.T) L.1.48 B5971 (I.T) L.1.49 B5972
(I.T) L.1.50 B5973 (I.T) L.1.51 B5974 (I.T) L.1.52 B5975 (I.T)
L.1.53 B5976 (I.T) L.1.54 B5977 (I.T) L.1.55 B5978 (I.T) L.1.56
B5979 (I.T) L.1.57 B5980 (I.T) L.1.58 B5981 (I.T) L.1.59 B5982
(I.T) L.1.60 B5983 (I.T) L.1.61 B5984 (I.T) L.1.62 B5985 (I.T)
L.1.63 B5986 (I.T) L.1.64 B5987 (I.T) L.1.65 B5988 (I.T) L.1.66
B5989 (I.T) L.1.67 B5990 (I.T) L.1.68 B5991 (I.T) L.1.69 B5992
(I.T) L.1.70 B5993 (I.T) L.1.71 B5994 (I.T) L.1.72 B5995 (I.T)
L.1.73 B5996 (I.T) L.1.74 B5997 (I.T) L.1.75 B5998 (I.T) L.1.76
B5999 (I.T) L.1.77 B6000 (I.T) L.1.78 B6001 (I.T) L.1.79 B6002
(I.T) L.1.80 B6003 (I.T) L.1.81 B6004 (I.T) L.1.82 B6005 (I.T)
L.1.83 B6006 (I.T) L.1.84 B6007 (I.T) L.1.85 B6008 (I.T) L.1.86
B6009 (I.T) L.1.87 B6010 (I.T) L.1.88 B6011 (I.T) L.1.89 B6012
(I.T) L.1.90 B6013 (I.T) L.1.91 B6014 (I.T) L.1.92 B6015 (I.T)
L.1.93 B6016 (I.T) L.1.94 B6017 (I.T) L.1.95 B6018 (I.T) L.1.96
B6019 (I.T) L.2.1 B6020 (I.T) L.2.2 B6021 (I.T) L.2.3 B6022 (I.T)
L.2.4 B6023 (I.T) L.2.5 B6024 (I.T) L.2.6 B6025 (I.T) L.2.7 B6026
(I.T) L.2.8 B6027 (I.T) L.2.9 B6028 (I.T) L.2.10 B6029 (I.T) L.2.11
B6030 (I.T) L.2.12 B6031 (I.T) L.2.13 B6032 (I.T) L.2.14 B6033
(I.T) L.2.15 B6034 (I.T) L.2.16 B6035 (I.T) L.2.17 B6036 (I.T)
L.2.18 B6037 (I.T) L.2.19 B6038 (I.T) L.2.20 B6039 (I.T) L.2.21
B6040 (I.T) L.2.22 B6041 (I.T) L.2.23 B6042 (I.T) L.2.24 B6043
(I.T) L.2.25 B6044 (I.T) L.2.26 B6045 (I.T) L.2.27 B6046 (I.T)
L.2.28 B6047 (I.T) L.2.29 B6048 (I.T) L.2.30 B6049 (I.T) L.2.31
B6050 (I.T) L.2.32 B6051 (I.T) L.2.33 B6052 (I.T) L.3.1 B6053 (I.T)
L.3.2 B6054 (I.T) L.3.3 B6055 (I.T) L.3.4 B6056 (I.T) L.3.5 B6057
(I.T) L.3.6 B6058 (I.T) L.3.7 B6059 (I.T) L.3.8 B6060 (I.T) L.3.9
B6061 (I.T) L.3.10 B6062 (I.T) L.3.11 B6063 (I.T) L.3.12 B6064
(I.T) L.3.13 B6065 (I.T) L.3.14 B6066 (I.T) L.3.15 B6067 (I.T)
L.3.16 B6068 (I.T) L.3.17 B6069 (I.T) L.3.18 B6070 (I.T) L.3.19
B6071 (I.T) L.3.20 B6072 (I.T) L.3.21 B6073 (I.T) L.3.22 B6074
(I.T) L.3.23 B6075 (I.T) L.3.24 B6076 (I.T) L.3.25 B6077 (I.T)
L.3.26 B6078 (I.T) L.3.27 B6079 (I.T) L.3.28 B6080 (I.T) L.3.29
B6081 (I.T) L.3.30 B6082 (I.T) L.3.31 B6083 (I.T) L.3.32 B6084
(I.T) L.3.33 B6085 (I.T) L.3.34 B6086 (I.T) L.3.35 B6087 (I.T)
L.3.36 B6088 (I.T) L.3.37 B6089 (I.T) L.3.38 B6090 (I.T) L.3.39
B6091 (I.T) L.3.40 B6092 (I.T) L.3.41 B6093 (I.T) L.3.42 B6094
(I.T) L.3.43 B6095 (I.T) L.3.44 B6096 (I.T) L.3.45 B6097 (I.T)
L.3.46 B6098 (I.T) L.3.47 B6099 (I.T) L.3.48 B6100 (I.T) L.3.49
B6101 (I.T) L.3.50 B6102 (I.T) L.3.51 B6103 (I.T) L.3.52 B6104
(I.T) L.3.53 B6105 (I.T) L.3.54 B6106 (I.T) L.3.55 B6107 (I.T)
L.3.56 B6108 (I.T) L.3.57 B6109 (I.T) L.3.58 B6110 (I.T) L.3.59
B6111 (I.T) L.3.60 B6112 (I.T) L.3.61 B6113 (I.T) L.3.62 B6114
(I.T) L.3.63 B6115 (I.T) L.3.1 B6116 (I.T) L.3.2 B6117 (I.T) L.4.1
B6118 (I.T) L.4.2 B6119 (I.T) L.4.3 B6120 (I.T) L.4.4 B6121 (I.T)
L.4.5 B6122 (I.T) L.4.6 B6123 (I.T) L.4.7 B6124 (I.T) L.4.8 B6125
(I.T) L.4.9 B6126 (I.T) L.4.10 B6127 (I.T) L.4.11 B6128 (I.T)
L.4.12 B6129 (I.T) L.4.13 B6130 (I.T) L.4.14 B6131 (I.T) L.4.15
B6132 (I.T) L.4.16 B6133 (I.T) L.4.17 B6134 (I.T) L.4.18 B6135
(I.T) L.4.19 B6136 (I.T) L.4.20 B6137 (I.T) L.4.21 B6138 (I.T)
L.4.22 B6139 (I.T) L.4.23 B6140 (I.T) L.4.24 B6141 (I.T) L.4.25
B6142 (I.T) L.4.26 B6143 (I.T) L.4.27 B6144 (I.T) L.4.28 B6145
(I.T) L.4.29 B6146 (I.T) L.4.30 B6147 (I.T) L.4.31 B6148 (I.T)
L.4.32 B6149 (I.T) L.4.33 B6150 (I.T) L.5.1 B6151 (I.T) L.5.2 B6152
(I.T) L.5.3 B6153 (I.T) L.5.4 B6154 (I.T) L.5.5 B6155 (I.T) L.5.6
B6156 (I.T) L.5.7 B6157 (I.T) L.5.8 B6158 (I.T) L.5.9 B6159 (I.T)
L.5.10 B6160 (I.T) L.5.11 B6161 (I.T) L.5.12 B6162 (I.T) L.5.13
B6163 (I.T) L.5.14 B6164 (I.T) L.5.15 B6165 (I.T) L.5.16 B6166
(I.T) L.5.17 B6167 (I.T) L.5.18 B6168 (I.T) L.5.19
B6169 (I.T) L.5.20 B6170 (I.T) L.5.21 B6171 (I.T) L.5.22 B6172
(I.T) L.5.23 B6173 (I.T) L.5.24 B6174 (I.T) L.5.25 B6175 (I.T)
L.5.26 B6176 (I.T) L.5.27 B6177 (I.T) L.5.28 B6178 (I.T) L.5.29
B6179 (I.T) L.5.30 B6180 (I.T) L.5.31 B6181 (I.T) L.5.32 B6182
(I.T) L.5.33 B6183 (I.T) L.5.34 B6184 (I.T) L.5.35 B6185 (I.T)
L.5.36 B6186 (I.T) L.5.37 B6187 (I.T) L.5.38 B6188 (I.T) L.5.39
B6189 (I.T) L.5.40 B6190 (I.T) L.5.41 B6191 (I.T) L.5.42 B6192
(I.T) L.5.43 B6193 (I.T) L.5.44 B6194 (I.T) L.5.45 B6195 (I.T)
L.5.46 B6196 (I.T) L.5.47 B6197 (I.T) L.5.48 B6198 (I.T) L.5.49
B6199 (I.T) L.5.50 B6200 (I.T) L.5.51 B6201 (I.T) L.5.52 B6202
(I.T) L.5.53 B6203 (I.T) L.5.54 B6204 (I.T) L.5.55 B6205 (I.T)
L.5.56 B6206 (I.T) L.5.57 B6207 (I.T) L.5.58 B6208 (I.T) L.5.59
B6209 (I.T) L.5.60 B6210 (I.T) L.5.61 B6211 (I.T) L.5.62 B6212
(I.T) L.5.63 B6213 (I.T) L.5.64 B6214 (I.T) L.5.65 B6215 (I.T)
L.5.66 B6216 (I.T) L.5.67 B6217 (I.T) L.5.68 B6218 (I.T) L.5.69
B6219 (I.T) L.5.70 B6220 (I.T) L.5.71 B6221 (I.T) L.5.72 B6222
(I.T) L.5.73 B6223 (I.T) L.5.74 B6224 (I.T) L.5.75 B6225 (I.T)
L.5.76 B6226 (I.T) L.5.77 B6227 (I.T) L.5.78 B6228 (I.T) L.5.79
B6229 (I.T) L.5.80 B6230 (I.T) L.5.81 B6231 (I.T) L.5.82 B6232
(I.T) L.5.83 B6233 (I.T) L.5.84 B6234 (I.T) L.6.1 B6235 (I.T) L.6.2
B6236 (I.T) L.6.3 B6237 (I.T) L.6.4 B6238 (I.T) L.6.5 B6239 (I.T)
L.6.6 B6240 (I.T) L.6.7 B6241 (I.T) L.6.8 B6242 (I.T) L.6.9 B6243
(I.T) L.6.10 B6244 (I.T) L.6.11 B6245 (I.T) L.6.12 B6246 (I.T)
L.6.13 B6247 (I.T) L.6.14 B6248 (I.T) L.6.15 B6249 (I.T) L.6.16
B6251 (I.T) L.6.18 B6250 (I.T) L.6.17 B = Mixture; I = compound I;
II = compound II;
TABLE-US-00021 TABLE 69 B I II B6252 (I.U) L.1.1 B6253 (I.U) L.1.2
B6254 (I.U) L.1.3 B6255 (I.U) L.1.4 B6256 (I.U) L.1.5 B6257 (I.U)
L.1.6 B6258 (I.U) L.1.7 B6259 (I.U) L.1.8 B6260 (I.U) L.1.9 B6261
(I.U) L.1.10 B6262 (I.U) L.1.11 B6263 (I.U) L.1.12 B6264 (I.U)
L.1.13 B6265 (I.U) L.1.14 B6266 (I.U) L.1.15 B6267 (I.U) L.1.16
B6268 (I.U) L.1.17 B6269 (I.U) L.1.18 B6270 (I.U) L.1.19 B6271
(I.U) L.1.20 B6272 (I.U) L.1.21 B6273 (I.U) L.1.22 B6274 (I.U)
L.1.23 B6275 (I.U) L.1.24 B6276 (I.U) L.1.25 B6277 (I.U) L.1.26
B6278 (I.U) L.1.27 B6279 (I.U) L.1.28 B6280 (I.U) L.1.29 B6281
(I.U) L.1.30 B6282 (I.U) L.1.31 B6283 (I.U) L.1.32 B6284 (I.U)
L.1.33 B6285 (I.U) L.1.34 B6286 (I.U) L.1.35 B6287 (I.U) L.1.36
B6288 (I.U) L.1.37 B6289 (I.U) L.1.38 B6290 (I.U) L.1.39 B6291
(I.U) L.1.40 B6292 (I.U) L.1.41 B6293 (I.U) L.1.42 B6294 (I.U)
L.1.43 B6295 (I.U) L.1.44 B6296 (I.U) L.1.45 B6297 (I.U) L.1.46
B6298 (I.U) L.1.47 B6299 (I.U) L.1.48 B6300 (I.U) L.1.49 B6301
(I.U) L.1.50 B6302 (I.U) L.1.51 B6303 (I.U) L.1.52 B6304 (I.U)
L.1.53 B6305 (I.U) L.1.54 B6306 (I.U) L.1.55 B6307 (I.U) L.1.56
B6308 (I.U) L.1.57 B6309 (I.U) L.1.58 B6310 (I.U) L.1.59 B6311
(I.U) L.1.60 B6312 (I.U) L.1.61 B6313 (I.U) L.1.62 B6314 (I.U)
L.1.63 B6315 (I.U) L.1.64 B6316 (I.U) L.1.65 B6317 (I.U) L.1.66
B6318 (I.U) L.1.67 B6319 (I.U) L.1.68 B6320 (I.U) L.1.69 B6321
(I.U) L.1.70 B6322 (I.U) L.1.71 B6323 (I.U) L.1.72 B6324 (I.U)
L.1.73 B6325 (I.U) L.1.74 B6326 (I.U) L.1.75 B6327 (I.U) L.1.76
B6328 (I.U) L.1.77 B6329 (I.U) L.1.78 B6330 (I.U) L.1.79 B6331
(I.U) L.1.80 B6332 (I.U) L.1.81 B6333 (I.U) L.1.82 B6334 (I.U)
L.1.83 B6335 (I.U) L.1.84 B6336 (I.U) L.1.85 B6337 (I.U) L.1.86
B6338 (I.U) L.1.87 B6339 (I.U) L.1.88 B6340 (I.U) L.1.89 B6341
(I.U) L.1.90 B6342 (I.U) L.1.91 B6343 (I.U) L.1.92 B6344 (I.U)
L.1.93 B6345 (I.U) L.1.94 B6346 (I.U) L.1.95 B6347 (I.U) L.1.96
B6348 (I.U) L.2.1 B6349 (I.U) L.2.2 B6350 (I.U) L.2.3 B6351 (I.U)
L.2.4 B6352 (I.U) L.2.5 B6353 (I.U) L.2.6 B6354 (I.U) L.2.7 B6355
(I.U) L.2.8 B6356 (I.U) L.2.9 B6357 (I.U) L.2.10 B6358 (I.U) L.2.11
B6359 (I.U) L.2.12 B6360 (I.U) L.2.13 B6361 (I.U) L.2.14 B6362
(I.U) L.2.15 B6363 (I.U) L.2.16 B6364 (I.U) L.2.17 B6365 (I.U)
L.2.18 B6366 (I.U) L.2.19 B6367 (I.U) L.2.20 B6368 (I.U) L.2.21
B6369 (I.U) L.2.22 B6370 (I.U) L.2.23 B6371 (I.U) L.2.24 B6372
(I.U) L.2.25 B6373 (I.U) L.2.26 B6374 (I.U) L.2.27 B6375 (I.U)
L.2.28 B6376 (I.U) L.2.29 B6377 (I.U) L.2.30 B6378 (I.U) L.2.31
B6379 (I.U) L.2.32 B6380 (I.U) L.2.33 B6381 (I.U) L.3.1 B6382 (I.U)
L.3.2 B6383 (I.U) L.3.3 B6384 (I.U) L.3.4 B6385 (I.U) L.3.5 B6386
(I.U) L.3.6 B6387 (I.U) L.3.7 B6388 (I.U) L.3.8 B6389 (I.U) L.3.9
B6390 (I.U) L.3.10 B6391 (I.U) L.3.11 B6392 (I.U) L.3.12 B6393
(I.U) L.3.13 B6394 (I.U) L.3.14 B6395 (I.U) L.3.15 B6396 (I.U)
L.3.16 B6397 (I.U) L.3.17 B6398 (I.U) L.3.18 B6399 (I.U) L.3.19
B6400 (I.U) L.3.20 B6401 (I.U) L.3.21 B6402 (I.U) L.3.22 B6403
(I.U) L.3.23 B6404 (I.U) L.3.24 B6405 (I.U) L.3.25 B6406 (I.U)
L.3.26 B6407 (I.U) L.3.27 B6408 (I.U) L.3.28 B6409 (I.U) L.3.29
B6410 (I.U) L.3.30 B6411 (I.U) L.3.31 B6412 (I.U) L.3.32 B6413
(I.U) L.3.33 B6414 (I.U) L.3.34 B6415 (I.U) L.3.35 B6416 (I.U)
L.3.36 B6417 (I.U) L.3.37 B6418 (I.U) L.3.38 B6419 (I.U) L.3.39
B6420 (I.U) L.3.40 B6421 (I.U) L.3.41 B6422 (I.U) L.3.42 B6423
(I.U) L.3.43 B6424 (I.U) L.3.44 B6425 (I.U) L.3.45 B6426 (I.U)
L.3.46 B6427 (I.U) L.3.47 B6428 (I.U) L.3.48 B6429 (I.U) L.3.49
B6430 (I.U) L.3.50 B6431 (I.U) L.3.51 B6432 (I.U) L.3.52 B6433
(I.U) L.3.53 B6434 (I.U) L.3.54 B6435 (I.U) L.3.55 B6436 (I.U)
L.3.56 B6437 (I.U) L.3.57 B6438 (I.U) L.3.58 B6439 (I.U) L.3.59
B6440 (I.U) L.3.60 B6441 (I.U) L.3.61 B6442 (I.U) L.3.62 B6443
(I.U) L.3.63 B6444 (I.U) L.3.1 B6445 (I.U) L.3.2 B6446 (I.U) L.4.1
B6447 (I.U) L.4.2 B6448 (I.U) L.4.3 B6449 (I.U) L.4.4 B6450 (I.U)
L.4.5 B6451 (I.U) L.4.6 B6452 (I.U) L.4.7 B6453 (I.U) L.4.8 B6454
(I.U) L.4.9 B6455 (I.U) L.4.10 B6456 (I.U) L.4.11 B6457 (I.U)
L.4.12 B6458 (I.U) L.4.13 B6459 (I.U) L.4.14 B6460 (I.U) L.4.15
B6461 (I.U) L.4.16 B6462 (I.U) L.4.17 B6463 (I.U) L.4.18 B6464
(I.U) L.4.19 B6465 (I.U) L.4.20 B6466 (I.U) L.4.21 B6467 (I.U)
L.4.22 B6468 (I.U) L.4.23 B6469 (I.U) L.4.24 B6470 (I.U) L.4.25
B6471 (I.U) L.4.26 B6472 (I.U) L.4.27 B6473 (I.U) L.4.28 B6474
(I.U) L.4.29 B6475 (I.U) L.4.30 B6476 (I.U) L.4.31 B6477 (I.U)
L.4.32 B6478 (I.U) L.4.33 B6479 (I.U) L.5.1 B6480 (I.U) L.5.2 B6481
(I.U) L.5.3 B6482 (I.U) L.5.4 B6483 (I.U) L.5.5 B6484 (I.U) L.5.6
B6485 (I.U) L.5.7 B6486 (I.U) L.5.8 B6487 (I.U) L.5.9 B6488 (I.U)
L.5.10 B6489 (I.U) L.5.11 B6490 (I.U) L.5.12 B6491 (I.U) L.5.13
B6492 (I.U) L.5.14 B6493 (I.U) L.5.15 B6494 (I.U) L.5.16 B6495
(I.U) L.5.17 B6496 (I.U) L.5.18 B6497 (I.U) L.5.19
B6498 (I.U) L.5.20 B6499 (I.U) L.5.21 B6500 (I.U) L.5.22 B6501
(I.U) L.5.23 B6502 (I.U) L.5.24 B6503 (I.U) L.5.25 B6504 (I.U)
L.5.26 B6505 (I.U) L.5.27 B6506 (I.U) L.5.28 B6507 (I.U) L.5.29
B6508 (I.U) L.5.30 B6509 (I.U) L.5.31 B6510 (I.U) L.5.32 B6511
(I.U) L.5.33 B6512 (I.U) L.5.34 B6513 (I.U) L.5.35 B6514 (I.U)
L.5.36 B6515 (I.U) L.5.37 B6516 (I.U) L.5.38 B6517 (I.U) L.5.39
B6518 (I.U) L.5.40 B6519 (I.U) L.5.41 B6520 (I.U) L.5.42 B6521
(I.U) L.5.43 B6522 (I.U) L.5.44 B6523 (I.U) L.5.45 B6524 (I.U)
L.5.46 B6525 (I.U) L.5.47 B6526 (I.U) L.5.48 B6527 (I.U) L.5.49
B6528 (I.U) L.5.50 B6529 (I.U) L.5.51 B6530 (I.U) L.5.52 B6531
(I.U) L.5.53 B6532 (I.U) L.5.54 B6533 (I.U) L.5.55 B6534 (I.U)
L.5.56 B6535 (I.U) L.5.57 B6536 (I.U) L.5.58 B6537 (I.U) L.5.59
B6538 (I.U) L.5.60 B6539 (I.U) L.5.61 B6540 (I.U) L.5.62 B6541
(I.U) L.5.63 B6542 (I.U) L.5.64 B6543 (I.U) L.5.65 B6544 (I.U)
L.5.66 B6545 (I.U) L.5.67 B6546 (I.U) L.5.68 B6547 (I.U) L.5.69
B6548 (I.U) L.5.70 B6549 (I.U) L.5.71 B6550 (I.U) L.5.72 B6551
(I.U) L.5.73 B6552 (I.U) L.5.74 B6553 (I.U) L.5.75 B6554 (I.U)
L.5.76 B6555 (I.U) L.5.77 B6556 (I.U) L.5.78 B6557 (I.U) L.5.79
B6558 (I.U) L.5.80 B6559 (I.U) L.5.81 B6560 (I.U) L.5.82 B6561
(I.U) L.5.83 B6562 (I.U) L.5.84 B6563 (I.U) L.6.1 B6564 (I.U) L.6.2
B6565 (I.U) L.6.3 B6566 (I.U) L.6.4 B6567 (I.U) L.6.5 B6568 (I.U)
L.6.6 B6569 (I.U) L.6.7 B6570 (I.U) L.6.8 B6571 (I.U) L.6.9 B6572
(I.U) L.6.10 B6573 (I.U) L.6.11 B6574 (I.U) L.6.12 B6575 (I.U)
L.6.13 B6576 (I.U) L.6.14 B6577 (I.U) L.6.15 B6578 (I.U) L.6.16
B6579 (I.U) L.6.17 B6580 (I.U) L.6.18 B = Mixture; I = compound I;
II = compound II
TABLE-US-00022 TABLE 70 B I II B6581 (I.V) L.1.1 B6582 (I.V) L.1.2
B6583 (I.V) L.1.3 B6584 (I.V) L.1.4 B6585 (I.V) L.1.5 B6586 (I.V)
L.1.6 B6587 (I.V) L.1.7 B6588 (I.V) L.1.8 B6589 (I.V) L.1.9 B6590
(I.V) L.1.10 B6591 (I.V) L.1.11 B6592 (I.V) L.1.12 B6593 (I.V)
L.1.13 B6594 (I.V) L.1.14 B6595 (I.V) L.1.15 B6596 (I.V) L.1.16
B6597 (I.V) L.1.17 B6598 (I.V) L.1.18 B6599 (I.V) L.1.19 B6600
(I.V) L.1.20 B6601 (I.V) L.1.21 B6602 (I.V) L.1.22 B6603 (I.V)
L.1.23 B6604 (I.V) L.1.24 B6605 (I.V) L.1.25 B6606 (I.V) L.1.26
B6607 (I.V) L.1.27 B6608 (I.V) L.1.28 B6609 (I.V) L.1.29 B6610
(I.V) L.1.30 B6611 (I.V) L.1.31 B6612 (I.V) L.1.32 B6613 (I.V)
L.1.33 B6614 (I.V) L.1.34 B6615 (I.V) L.1.35 B6616 (I.V) L.1.36
B6617 (I.V) L.1.37 B6618 (I.V) L.1.38 B6619 (I.V) L.1.39 B6620
(I.V) L.1.40 B6621 (I.V) L.1.41 B6622 (I.V) L.1.42 B6623 (I.V)
L.1.43 B6624 (I.V) L.1.44 B6625 (I.V) L.1.45 B6626 (I.V) L.1.46
B6627 (I.V) L.1.47 B6628 (I.V) L.1.48 B6629 (I.V) L.1.49 B6630
(I.V) L.1.50 B6631 (I.V) L.1.51 B6632 (I.V) L.1.52 B6633 (I.V)
L.1.53 B6634 (I.V) L.1.54 B6635 (I.V) L.1.55 B6636 (I.V) L.1.56
B6637 (I.V) L.1.57 B6638 (I.V) L.1.58 B6639 (I.V) L.1.59 B6640
(I.V) L.1.60 B6641 (I.V) L.1.61 B6642 (I.V) L.1.62 B6643 (I.V)
L.1.63 B6644 (I.V) L.1.64 B6645 (I.V) L.1.65 B6646 (I.V) L.1.66
B6647 (I.V) L.1.67 B6648 (I.V) L.1.68 B6649 (I.V) L.1.69 B6650
(I.V) L.1.70 B6651 (I.V) L.1.71 B6652 (I.V) L.1.72 B6653 (I.V)
L.1.73 B6654 (I.V) L.1.74 B6655 (I.V) L.1.75 B6656 (I.V) L.1.76
B6657 (I.V) L.1.77 B6658 (I.V) L.1.78 B6659 (I.V) L.1.79 B6660
(I.V) L.1.80 B6661 (I.V) L.1.81 B6662 (I.V) L.1.82 B6663 (I.V)
L.1.83 B6664 (I.V) L.1.84 B6665 (I.V) L.1.85 B6666 (I.V) L.1.86
B6667 (I.V) L.1.87 B6668 (I.V) L.1.88 B6669 (I.V) L.1.89 B6670
(I.V) L.1.90 B6671 (I.V) L.1.91 B6672 (I.V) L.1.92 B6673 (I.V)
L.1.93 B6674 (I.V) L.1.94 B6675 (I.V) L.1.95 B6676 (I.V) L.1.96
B6677 (I.V) L.2.1 B6678 (I.V) L.2.2 B6679 (I.V) L.2.3 B6680 (I.V)
L.2.4 B6681 (I.V) L.2.5 B6682 (I.V) L.2.6 B6683 (I.V) L.2.7 B6684
(I.V) L.2.8 B6685 (I.V) L.2.9 B6686 (I.V) L.2.10 B6687 (I.V) L.2.11
B6688 (I.V) L.2.12 B6689 (I.V) L.2.13 B6690 (I.V) L.2.14 B6691
(I.V) L.2.15 B6692 (I.V) L.2.16 B6693 (I.V) L.2.17 B6694 (I.V)
L.2.18 B6695 (I.V) L.2.19 B6696 (I.V) L.2.20 B6697 (I.V) L.2.21
B6698 (I.V) L.2.22 B6699 (I.V) L.2.23 B6700 (I.V) L.2.24 B6701
(I.V) L.2.25 B6702 (I.V) L.2.26 B6703 (I.V) L.2.27 B6704 (I.V)
L.2.28 B6705 (I.V) L.2.29 B6706 (I.V) L.2.30 B6707 (I.V) L.2.31
B6708 (I.V) L.2.32 B6709 (I.V) L.2.33 B6710 (I.V) L.3.1 B6711 (I.V)
L.3.2 B6712 (I.V) L.3.3 B6713 (I.V) L.3.4 B6714 (I.V) L.3.5 B6715
(I.V) L.3.6 B6716 (I.V) L.3.7 B6717 (I.V) L.3.8 B6718 (I.V) L.3.9
B6719 (I.V) L.3.10 B6720 (I.V) L.3.11 B6721 (I.V) L.3.12 B6722
(I.V) L.3.13 B6723 (I.V) L.3.14 B6724 (I.V) L.3.15 B6725 (I.V)
L.3.16 B6726 (I.V) L.3.17 B6727 (I.V) L.3.18 B6728 (I.V) L.3.19
B6729 (I.V) L.3.20 B6730 (I.V) L.3.21 B6731 (I.V) L.3.22 B6732
(I.V) L.3.23 B6733 (I.V) L.3.24 B6734 (I.V) L.3.25 B6735 (I.V)
L.3.26 B6736 (I.V) L.3.27 B6737 (I.V) L.3.28 B6738 (I.V) L.3.29
B6739 (I.V) L.3.30 B6740 (I.V) L.3.31 B6741 (I.V) L.3.32 B6742
(I.V) L.3.33 B6743 (I.V) L.3.34 B6744 (I.V) L.3.35 B6745 (I.V)
L.3.36 B6746 (I.V) L.3.37 B6747 (I.V) L.3.38 B6748 (I.V) L.3.39
B6749 (I.V) L.3.40 B6750 (I.V) L.3.41 B6751 (I.V) L.3.42 B6752
(I.V) L.3.43 B6753 (I.V) L.3.44 B6754 (I.V) L.3.45 B6755 (I.V)
L.3.46 B6756 (I.V) L.3.47 B6757 (I.V) L.3.48 B6758 (I.V) L.3.49
B6759 (I.V) L.3.50 B6760 (I.V) L.3.51 B6761 (I.V) L.3.52 B6762
(I.V) L.3.53 B6763 (I.V) L.3.54 B6764 (I.V) L.3.55 B6765 (I.V)
L.3.56 B6766 (I.V) L.3.57 B6767 (I.V) L.3.58 B6768 (I.V) L.3.59
B6769 (I.V) L.3.60 B6770 (I.V) L.3.61 B6771 (I.V) L.3.62 B6772
(I.V) L.3.63 B6773 (I.V) L.3.1 B6774 (I.V) L.3.2 B6775 (I.V) L.4.1
B6776 (I.V) L.4.2 B6777 (I.V) L.4.3 B6778 (I.V) L.4.4 B6779 (I.V)
L.4.5 B6780 (I.V) L.4.6 B6781 (I.V) L.4.7 B6782 (I.V) L.4.8 B6783
(I.V) L.4.9 B6784 (I.V) L.4.10 B6785 (I.V) L.4.11 B6786 (I.V)
L.4.12 B6787 (I.V) L.4.13 B6788 (I.V) L.4.14 B6789 (I.V) L.4.15
B6790 (I.V) L.4.16 B6791 (I.V) L.4.17 B6792 (I.V) L.4.18 B6793
(I.V) L.4.19 B6794 (I.V) L.4.20 B6795 (I.V) L.4.21 B6796 (I.V)
L.4.22 B6797 (I.V) L.4.23 B6798 (I.V) L.4.24 B6799 (I.V) L.4.25
B6800 (I.V) L.4.26 B6801 (I.V) L.4.27 B6802 (I.V) L.4.28 B6803
(I.V) L.4.29 B6804 (I.V) L.4.30 B6805 (I.V) L.4.31 B6806 (I.V)
L.4.32 B6807 (I.V) L.4.33 B6808 (I.V) L.5.1 B6809 (I.V) L.5.2 B6810
(I.V) L.5.3 B6811 (I.V) L.5.4 B6812 (I.V) L.5.5 B6813 (I.V) L.5.6
B6814 (I.V) L.5.7 B6815 (I.V) L.5.8 B6816 (I.V) L.5.9 B6817 (I.V)
L.5.10 B6818 (I.V) L.5.11 B6819 (I.V) L.5.12 B6820 (I.V) L.5.13
B6821 (I.V) L.5.14 B6822 (I.V) L.5.15 B6823 (I.V) L.5.16 B6824
(I.V) L.5.17 B6825 (I.V) L.5.18 B6826 (I.V) L.5.19
B6827 (I.V) L.5.20 B6828 (I.V) L.5.21 B6829 (I.V) L.5.22 B6830
(I.V) L.5.23 B6831 (I.V) L.5.24 B6832 (I.V) L.5.25 B6833 (I.V)
L.5.26 B6834 (I.V) L.5.27 B6835 (I.V) L.5.28 B6836 (I.V) L.5.29
B6837 (I.V) L.5.30 B6838 (I.V) L.5.31 B6839 (I.V) L.5.32 B6840
(I.V) L.5.33 B6841 (I.V) L.5.34 B6842 (I.V) L.5.35 B6843 (I.V)
L.5.36 B6844 (I.V) L.5.37 B6845 (I.V) L.5.38 B6846 (I.V) L.5.39
B6847 (I.V) L.5.40 B6848 (I.V) L.5.41 B6849 (I.V) L.5.42 B6850
(I.V) L.5.43 B6851 (I.V) L.5.44 B6852 (I.V) L.5.45 B6853 (I.V)
L.5.46 B6854 (I.V) L.5.47 B6855 (I.V) L.5.48 B6856 (I.V) L.5.49
B6857 (I.V) L.5.50 B6858 (I.V) L.5.51 B6859 (I.V) L.5.52 B6860
(I.V) L.5.53 B6861 (I.V) L.5.54 B6862 (I.V) L.5.55 B6863 (I.V)
L.5.56 B6864 (I.V) L.5.57 B6865 (I.V) L.5.58 B6866 (I.V) L.5.59
B6867 (I.V) L.5.60 B6868 (I.V) L.5.61 B6869 (I.V) L.5.62 B6870
(I.V) L.5.63 B6871 (I.V) L.5.64 B6872 (I.V) L.5.65 B6873 (I.V)
L.5.66 B6874 (I.V) L.5.67 B6875 (I.V) L.5.68 B6876 (I.V) L.5.69
B6877 (I.V) L.5.70 B6878 (I.V) L.5.71 B6879 (I.V) L.5.72 B6880
(I.V) L.5.73 B6881 (I.V) L.5.74 B6882 (I.V) L.5.75 B6883 (I.V)
L.5.76 B6884 (I.V) L.5.77 B6885 (I.V) L.5.78 B6886 (I.V) L.5.79
B6887 (I.V) L.5.80 B6888 (I.V) L.5.81 B6889 (I.V) L.5.82 B6890
(I.V) L.5.83 B6891 (I.V) L.5.84 B6892 (I.V) L.6.1 B6893 (I.V) L.6.2
B6894 (I.V) L.6.3 B6895 (I.V) L.6.4 B6896 (I.V) L.6.5 B6897 (I.V)
L.6.6 B6898 (I.V) L.6.7 B6899 (I.V) L.6.8 B6900 (I.V) L.6.9 B6901
(I.V) L.6.10 B6902 (I.V) L.6.11 B6903 (I.V) L.6.12 B6904 (I.V)
L.6.13 B6905 (I.V) L.6.14 B6906 (I.V) L.6.15 B6907 (I.V) L.6.16
B6908 (I.V) L.6.17 B6909 (I.V) L.6.18 B = Mixture; I = compound I;
II = compound II
TABLE-US-00023 TABLE 71 B I II B6910 (I.W) L.1.1 B6911 (I.W) L.1.2
B6912 (I.W) L.1.3 B6913 (I.W) L.1.4 B6914 (I.W) L.1.5 B6915 (I.W)
L.1.6 B6916 (I.W) L.1.7 B6917 (I.W) L.1.8 B6918 (I.W) L.1.9 B6919
(I.W) L.1.10 B6920 (I.W) L.1.11 B6921 (I.W) L.1.12 B6922 (I.W)
L.1.13 B6923 (I.W) L.1.14 B6924 (I.W) L.1.15 B6925 (I.W) L.1.16
B6926 (I.W) L.1.17 B6927 (I.W) L.1.18 B6928 (I.W) L.1.19 B6929
(I.W) L.1.20 B6930 (I.W) L.1.21 B6931 (I.W) L.1.22 B6932 (I.W)
L.1.23 B6933 (I.W) L.1.24 B6934 (I.W) L.1.25 B6935 (I.W) L.1.26
B6936 (I.W) L.1.27 B6937 (I.W) L.1.28 B6938 (I.W) L.1.29 B6939
(I.W) L.1.30 B6940 (I.W) L.1.31 B6941 (I.W) L.1.32 B6942 (I.W)
L.1.33 B6943 (I.W) L.1.34 B6944 (I.W) L.1.35 B6945 (I.W) L.1.36
B6946 (I.W) L.1.37 B6947 (I.W) L.1.38 B6948 (I.W) L.1.39 B6949
(I.W) L.1.40 B6950 (I.W) L.1.41 B6951 (I.W) L.1.42 B6952 (I.W)
L.1.43 B6953 (I.W) L.1.44 B6954 (I.W) L.1.45 B6955 (I.W) L.1.46
B6956 (I.W) L.1.47 B6957 (I.W) L.1.48 B6958 (I.W) L.1.49 B6959
(I.W) L.1.50 B6960 (I.W) L.1.51 B6961 (I.W) L.1.52 B6962 (I.W)
L.1.53 B6963 (I.W) L.1.54 B6964 (I.W) L.1.55 B6965 (I.W) L.1.56
B6966 (I.W) L.1.57 B6967 (I.W) L.1.58 B6968 (I.W) L.1.59 B6969
(I.W) L.1.60 B6970 (I.W) L.1.61 B6971 (I.W) L.1.62 B6972 (I.W)
L.1.63 B6973 (I.W) L.1.64 B6974 (I.W) L.1.65 B6975 (I.W) L.1.66
B6976 (I.W) L.1.67 B6977 (I.W) L.1.68 B6978 (I.W) L.1.69 B6979
(I.W) L.1.70 B6980 (I.W) L.1.71 B6981 (I.W) L.1.72 B6982 (I.W)
L.1.73 B6983 (I.W) L.1.74 B6984 (I.W) L.1.75 B6985 (I.W) L.1.76
B6986 (I.W) L.1.77 B6987 (I.W) L.1.78 B6988 (I.W) L.1.79 B6989
(I.W) L.1.80 B6990 (I.W) L.1.81 B6991 (I.W) L.1.82 B6992 (I.W)
L.1.83 B6993 (I.W) L.1.84 B6994 (I.W) L.1.85 B6995 (I.W) L.1.86
B6996 (I.W) L.1.87 B6997 (I.W) L.1.88 B6998 (I.W) L.1.89 B6999
(I.W) L.1.90 B7000 (I.W) L.1.91 B7001 (I.W) L.1.92 B7002 (I.W)
L.1.93 B7003 (I.W) L.1.94 B7004 (I.W) L.1.95 B7005 (I.W) L.1.96
B7006 (I.W) L.2.1 B7007 (I.W) L.2.2 B7008 (I.W) L.2.3 B7009 (I.W)
L.2.4 B7010 (I.W) L.2.5 B7011 (I.W) L.2.6 B7012 (I.W) L.2.7 B7013
(I.W) L.2.8 B7014 (I.W) L.2.9 B7015 (I.W) L.2.10 B7016 (I.W) L.2.11
B7017 (I.W) L.2.12 B7018 (I.W) L.2.13 B7019 (I.W) L.2.14 B7020
(I.W) L.2.15 B7021 (I.W) L.2.16 B7022 (I.W) L.2.17 B7023 (I.W)
L.2.18 B7024 (I.W) L.2.19 B7025 (I.W) L.2.20 B7026 (I.W) L.2.21
B7027 (I.W) L.2.22 B7028 (I.W) L.2.23 B7029 (I.W) L.2.24 B7030
(I.W) L.2.25 B7031 (I.W) L.2.26 B7032 (I.W) L.2.27 B7033 (I.W)
L.2.28 B7034 (I.W) L.2.29 B7035 (I.W) L.2.30 B7036 (I.W) L.2.31
B7037 (I.W) L.2.32 B7038 (I.W) L.2.33 B7039 (I.W) L.3.1 B7040 (I.W)
L.3.2 B7041 (I.W) L.3.3 B7042 (I.W) L.3.4 B7043 (I.W) L.3.5 B7044
(I.W) L.3.6 B7045 (I.W) L.3.7 B7046 (I.W) L.3.8 B7047 (I.W) L.3.9
B7048 (I.W) L.3.10 B7049 (I.W) L.3.11 B7050 (I.W) L.3.12 B7051
(I.W) L.3.13 B7052 (I.W) L.3.14 B7053 (I.W) L.3.15 B7054 (I.W)
L.3.16 B7055 (I.W) L.3.17 B7056 (I.W) L.3.18 B7057 (I.W) L.3.19
B7058 (I.W) L.3.20 B7059 (I.W) L.3.21 B7060 (I.W) L.3.22 B7061
(I.W) L.3.23 B7062 (I.W) L.3.24 B7063 (I.W) L.3.25 B7064 (I.W)
L.3.26 B7065 (I.W) L.3.27 B7066 (I.W) L.3.28 B7067 (I.W) L.3.29
B7068 (I.W) L.3.30 B7069 (I.W) L.3.31 B7070 (I.W) L.3.32 B7071
(I.W) L.3.33 B7072 (I.W) L.3.34 B7073 (I.W) L.3.35 B7074 (I.W)
L.3.36 B7075 (I.W) L.3.37 B7076 (I.W) L.3.38 B7077 (I.W) L.3.39
B7078 (I.W) L.3.40 B7079 (I.W) L.3.41 B7080 (I.W) L.3.42 B7081
(I.W) L.3.43 B7082 (I.W) L.3.44 B7083 (I.W) L.3.45 B7084 (I.W)
L.3.46 B7085 (I.W) L.3.47 B7086 (I.W) L.3.48 B7087 (I.W) L.3.49
B7088 (I.W) L.3.50 B7089 (I.W) L.3.51 B7090 (I.W) L.3.52 B7091
(I.W) L.3.53 B7092 (I.W) L.3.54 B7093 (I.W) L.3.55 B7094 (I.W)
L.3.56 B7095 (I.W) L.3.57 B7096 (I.W) L.3.58 B7097 (I.W) L.3.59
B7098 (I.W) L.3.60 B7099 (I.W) L.3.61 B7100 (I.W) L.3.62 B7101
(I.W) L.3.63 B7102 (I.W) L.3.1 B7103 (I.W) L.3.2 B7104 (I.W) L.4.1
B7105 (I.W) L.4.2 B7106 (I.W) L.4.3 B7107 (I.W) L.4.4 B7108 (I.W)
L.4.5 B7109 (I.W) L.4.6 B7110 (I.W) L.4.7 B7111 (I.W) L.4.8 B7112
(I.W) L.4.9 B7113 (I.W) L.4.10 B7114 (I.W) L.4.11 B7115 (I.W)
L.4.12 B7116 (I.W) L.4.13 B7117 (I.W) L.4.14 B7118 (I.W) L.4.15
B7119 (I.W) L.4.16 B7120 (I.W) L.4.17 B7121 (I.W) L.4.18 B7122
(I.W) L.4.19 B7123 (I.W) L.4.20 B7124 (I.W) L.4.21 B7125 (I.W)
L.4.22 B7126 (I.W) L.4.23 B7127 (I.W) L.4.24 B7128 (I.W) L.4.25
B7129 (I.W) L.4.26 B7130 (I.W) L.4.27 B7131 (I.W) L.4.28 B7132
(I.W) L.4.29 B7133 (I.W) L.4.30 B7134 (I.W) L.4.31 B7135 (I.W)
L.4.32 B7136 (I.W) L.4.33 B7137 (I.W) L.5.1 B7138 (I.W) L.5.2 B7139
(I.W) L.5.3 B7140 (I.W) L.5.4 B7141 (I.W) L.5.5 B7142 (I.W) L.5.6
B7143 (I.W) L.5.7 B7144 (I.W) L.5.8 B7145 (I.W) L.5.9 B7146 (I.W)
L.5.10 B7147 (I.W) L.5.11 B7148 (I.W) L.5.12 B7149 (I.W) L.5.13
B7150 (I.W) L.5.14 B7151 (I.W) L.5.15 B7152 (I.W) L.5.16 B7153
(I.W) L.5.17 B7154 (I.W) L.5.18 B7155 (I.W) L.5.19
B7156 (I.W) L.5.20 B7157 (I.W) L.5.21 B7158 (I.W) L.5.22 B7159
(I.W) L.5.23 B7160 (I.W) L.5.24 B7161 (I.W) L.5.25 B7162 (I.W)
L.5.26 B7163 (I.W) L.5.27 B7164 (I.W) L.5.28 B7165 (I.W) L.5.29
B7166 (I.W) L.5.30 B7167 (I.W) L.5.31 B7168 (I.W) L.5.32 B7169
(I.W) L.5.33 B7170 (I.W) L.5.34 B7171 (I.W) L.5.35 B7172 (I.W)
L.5.36 B7173 (I.W) L.5.37 B7174 (I.W) L.5.38 B7175 (I.W) L.5.39
B7176 (I.W) L.5.40 B7177 (I.W) L.5.41 B7178 (I.W) L.5.42 B7179
(I.W) L.5.43 B7180 (I.W) L.5.44 B7181 (I.W) L.5.45 B7182 (I.W)
L.5.46 B7183 (I.W) L.5.47 B7184 (I.W) L.5.48 B7185 (I.W) L.5.49
B7186 (I.W) L.5.50 B7187 (I.W) L.5.51 B7188 (I.W) L.5.52 B7189
(I.W) L.5.53 B7190 (I.W) L.5.54 B7191 (I.W) L.5.55 B7192 (I.W)
L.5.56 B7193 (I.W) L.5.57 B7194 (I.W) L.5.58 B7195 (I.W) L.5.59
B7196 (I.W) L.5.60 B7197 (I.W) L.5.61 B7198 (I.W) L.5.62 B7199
(I.W) L.5.63 B7200 (I.W) L.5.64 B7201 (I.W) L.5.65 B7202 (I.W)
L.5.66 B7203 (I.W) L.5.67 B7204 (I.W) L.5.68 B7205 (I.W) L.5.69
B7206 (I.W) L.5.70 B7207 (I.W) L.5.71 B7208 (I.W) L.5.72 B7209
(I.W) L.5.73 B7210 (I.W) L.5.74 B7211 (I.W) L.5.75 B7212 (I.W)
L.5.76 B7213 (I.W) L.5.77 B7214 (I.W) L.5.78 B7215 (I.W) L.5.79
B7216 (I.W) L.5.80 B7217 (I.W) L.5.81 B7218 (I.W) L.5.82 B7219
(I.W) L.5.83 B7220 (I.W) L.5.84 B7221 (I.W) L.6.1 B7222 (I.W) L.6.2
B7223 (I.W) L.6.3 B7224 (I.W) L.6.4 B7225 (I.W) L.6.5 B7226 (I.W)
L.6.6 B7227 (I.W) L.6.7 B7228 (I.W) L.6.8 B7229 (I.W) L.6.9 B7230
(I.W) L.6.10 B7231 (I.W) L.6.11 B7232 (I.W) L.6.12 B7233 (I.W)
L.6.13 B7234 (I.W) L.6.14 B7235 (I.W) L.6.15 B7236 (I.W) L.6.16
B7237 (I.W) L.6.17 B7238 (I.W) L.6.18 B = Mixture; I = compound I;
II = compound II
TABLE-US-00024 TABLE 72 B I II B7239 (I.X) L.1.1 B7240 (I.X) L.1.2
B7241 (I.X) L.1.3 B7242 (I.X) L.1.4 B7243 (I.X) L.1.5 B7244 (I.X)
L.1.6 B7245 (I.X) L.1.7 B7246 (I.X) L.1.8 B7247 (I.X) L.1.9 B7248
(I.X) L.1.10 B7249 (I.X) L.1.11 B7250 (I.X) L.1.12 B7251 (I.X)
L.1.13 B7252 (I.X) L.1.14 B7253 (I.X) L.1.15 B7254 (I.X) L.1.16
B7255 (I.X) L.1.17 B7256 (I.X) L.1.18 B7257 (I.X) L.1.19 B7258
(I.X) L.1.20 B7259 (I.X) L.1.21 B7260 (I.X) L.1.22 B7261 (I.X)
L.1.23 B7262 (I.X) L.1.24 B7263 (I.X) L.1.25 B7264 (I.X) L.1.26
B7265 (I.X) L.1.27 B7266 (I.X) L.1.28 B7267 (I.X) L.1.29 B7268
(I.X) L.1.30 B7269 (I.X) L.1.31 B7270 (I.X) L.1.32 B7271 (I.X)
L.1.33 B7272 (I.X) L.1.34 B7273 (I.X) L.1.35 B7274 (I.X) L.1.36
B7275 (I.X) L.1.37 B7276 (I.X) L.1.38 B7277 (I.X) L.1.39 B7278
(I.X) L.1.40 B7279 (I.X) L.1.41 B7280 (I.X) L.1.42 B7281 (I.X)
L.1.43 B7282 (I.X) L.1.44 B7283 (I.X) L.1.45 B7284 (I.X) L.1.46
B7285 (I.X) L.1.47 B7286 (I.X) L.1.48 B7287 (I.X) L.1.49 B7288
(I.X) L.1.50 B7289 (I.X) L.1.51 B7290 (I.X) L.1.52 B7291 (I.X)
L.1.53 B7292 (I.X) L.1.54 B7293 (I.X) L.1.55 B7294 (I.X) L.1.56
B7295 (I.X) L.1.57 B7296 (I.X) L.1.58 B7297 (I.X) L.1.59 B7298
(I.X) L.1.60 B7299 (I.X) L.1.61 B7300 (I.X) L.1.62 B7301 (I.X)
L.1.63 B7302 (I.X) L.1.64 B7303 (I.X) L.1.65 B7304 (I.X) L.1.66
B7305 (I.X) L.1.67 B7306 (I.X) L.1.68 B7307 (I.X) L.1.69 B7308
(I.X) L.1.70 B7309 (I.X) L.1.71 B7310 (I.X) L.1.72 B7311 (I.X)
L.1.73 B7312 (I.X) L.1.74 B7313 (I.X) L.1.75 B7314 (I.X) L.1.76
B7315 (I.X) L.1.77 B7316 (I.X) L.1.78 B7317 (I.X) L.1.79 B7318
(I.X) L.1.80 B7319 (I.X) L.1.81 B7320 (I.X) L.1.82 B7321 (I.X)
L.1.83 B7322 (I.X) L.1.84 B7323 (I.X) L.1.85 B7324 (I.X) L.1.86
B7325 (I.X) L.1.87 B7326 (I.X) L.1.88 B7327 (I.X) L.1.89 B7328
(I.X) L.1.90 B7329 (I.X) L.1.91 B7330 (I.X) L.1.92 B7331 (I.X)
L.1.93 B7332 (I.X) L.1.94 B7333 (I.X) L.1.95 B7334 (I.X) L.1.96
B7335 (I.X) L.2.1 B7336 (I.X) L.2.2 B7337 (I.X) L.2.3 B7338 (I.X)
L.2.4 B7339 (I.X) L.2.5 B7340 (I.X) L.2.6 B7341 (I.X) L.2.7 B7342
(I.X) L.2.8 B7343 (I.X) L.2.9 B7344 (I.X) L.2.10 B7345 (I.X) L.2.11
B7346 (I.X) L.2.12 B7347 (I.X) L.2.13 B7348 (I.X) L.2.14 B7349
(I.X) L.2.15 B7350 (I.X) L.2.16 B7351 (I.X) L.2.17 B7352 (I.X)
L.2.18 B7353 (I.X) L.2.19 B7354 (I.X) L.2.20 B7355 (I.X) L.2.21
B7356 (I.X) L.2.22 B7357 (I.X) L.2.23 B7358 (I.X) L.2.24 B7359
(I.X) L.2.25 B7360 (I.X) L.2.26 B7361 (I.X) L.2.27 B7362 (I.X)
L.2.28 B7363 (I.X) L.2.29 B7364 (I.X) L.2.30 B7365 (I.X) L.2.31
B7366 (I.X) L.2.32 B7367 (I.X) L.2.33 B7368 (I.X) L.3.1 B7369 (I.X)
L.3.2 B7370 (I.X) L.3.3 B7371 (I.X) L.3.4 B7372 (I.X) L.3.5 B7373
(I.X) L.3.6 B7374 (I.X) L.3.7 B7375 (I.X) L.3.8 B7376 (I.X) L.3.9
B7377 (I.X) L.3.10 B7378 (I.X) L.3.11 B7379 (I.X) L.3.12 B7380
(I.X) L.3.13 B7381 (I.X) L.3.14 B7382 (I.X) L.3.15 B7383 (I.X)
L.3.16 B7384 (I.X) L.3.17 B7385 (I.X) L.3.18 B7386 (I.X) L.3.19
B7387 (I.X) L.3.20 B7388 (I.X) L.3.21 B7389 (I.X) L.3.22 B7390
(I.X) L.3.23 B7391 (I.X) L.3.24 B7392 (I.X) L.3.25 B7393 (I.X)
L.3.26 B7394 (I.X) L.3.27 B7395 (I.X) L.3.28 B7396 (I.X) L.3.29
B7397 (I.X) L.3.30 B7398 (I.X) L.3.31 B7399 (I.X) L.3.32 B7400
(I.X) L.3.33 B7401 (I.X) L.3.34 B7402 (I.X) L.3.35 B7403 (I.X)
L.3.36 B7404 (I.X) L.3.37 B7405 (I.X) L.3.38 B7406 (I.X) L.3.39
B7407 (I.X) L.3.40 B7408 (I.X) L.3.41 B7409 (I.X) L.3.42 B7410
(I.X) L.3.43 B7411 (I.X) L.3.44 B7412 (I.X) L.3.45 B7413 (I.X)
L.3.46 B7414 (I.X) L.3.47 B7415 (I.X) L.3.48 B7416 (I.X) L.3.49
B7417 (I.X) L.3.50 B7418 (I.X) L.3.51 B7419 (I.X) L.3.52 B7420
(I.X) L.3.53 B7421 (I.X) L.3.54 B7422 (I.X) L.3.55 B7423 (I.X)
L.3.56 B7424 (I.X) L.3.57 B7425 (I.X) L.3.58 B7426 (I.X) L.3.59
B7427 (I.X) L.3.60 B7428 (I.X) L.3.61 B7429 (I.X) L.3.62 B7430
(I.X) L.3.63 B7431 (I.X) L.3.1 B7432 (I.X) L.3.2 B7433 (I.X) L.4.1
B7434 (I.X) L.4.2 B7435 (I.X) L.4.3 B7436 (I.X) L.4.4 B7437 (I.X)
L.4.5 B7438 (I.X) L.4.6 B7439 (I.X) L.4.7 B7440 (I.X) L.4.8 B7441
(I.X) L.4.9 B7442 (I.X) L.4.10 B7443 (I.X) L.4.11 B7444 (I.X)
L.4.12 B7445 (I.X) L.4.13 B7446 (I.X) L.4.14 B7447 (I.X) L.4.15
B7448 (I.X) L.4.16 B7449 (I.X) L.4.17 B7450 (I.X) L.4.18 B7451
(I.X) L.4.19 B7452 (I.X) L.4.20 B7453 (I.X) L.4.21 B7454 (I.X)
L.4.22 B7455 (I.X) L.4.23 B7456 (I.X) L.4.24 B7457 (I.X) L.4.25
B7458 (I.X) L.4.26 B7459 (I.X) L.4.27 B7460 (I.X) L.4.28 B7461
(I.X) L.4.29 B7462 (I.X) L.4.30 B7463 (I.X) L.4.31 B7464 (I.X)
L.4.32 B7465 (I.X) L.4.33 B7466 (I.X) L.5.1 B7467 (I.X) L.5.2 B7468
(I.X) L.5.3 B7469 (I.X) L.5.4 B7470 (I.X) L.5.5 B7471 (I.X) L.5.6
B7472 (I.X) L.5.7 B7473 (I.X) L.5.8 B7474 (I.X) L.5.9 B7475 (I.X)
L.5.10 B7476 (I.X) L.5.11 B7477 (I.X) L.5.12 B7478 (I.X) L.5.13
B7479 (I.X) L.5.14 B7480 (I.X) L.5.15 B7481 (I.X) L.5.16 B7482
(I.X) L.5.17 B7483 (I.X) L.5.18 B7484 (I.X) L.5.19
B7485 (I.X) L.5.20 B7486 (I.X) L.5.21 B7487 (I.X) L.5.22 B7488
(I.X) L.5.23 B7489 (I.X) L.5.24 B7490 (I.X) L.5.25 B7491 (I.X)
L.5.26 B7492 (I.X) L.5.27 B7493 (I.X) L.5.28 B7494 (I.X) L.5.29
B7495 (I.X) L.5.30 B7496 (I.X) L.5.31 B7497 (I.X) L.5.32 B7498
(I.X) L.5.33 B7499 (I.X) L.5.34 B7500 (I.X) L.5.35 B7501 (I.X)
L.5.36 B7502 (I.X) L.5.37 B7503 (I.X) L.5.38 B7504 (I.X) L.5.39
B7505 (I.X) L.5.40 B7506 (I.X) L.5.41 B7507 (I.X) L.5.42 B7508
(I.X) L.5.43 B7509 (I.X) L.5.44 B7510 (I.X) L.5.45 B7511 (I.X)
L.5.46 B7512 (I.X) L.5.47 B7513 (I.X) L.5.48 B7514 (I.X) L.5.49
B7515 (I.X) L.5.50 B7516 (I.X) L.5.51 B7517 (I.X) L.5.52 B7518
(I.X) L.5.53 B7519 (I.X) L.5.54 B7520 (I.X) L.5.55 B7521 (I.X)
L.5.56 B7522 (I.X) L.5.57 B7523 (I.X) L.5.58 B7524 (I.X) L.5.59
B7525 (I.X) L.5.60 B7526 (I.X) L.5.61 B7527 (I.X) L.5.62 B7528
(I.X) L.5.63 B7529 (I.X) L.5.64 B7530 (I.X) L.5.65 B7531 (I.X)
L.5.66 B7532 (I.X) L.5.67 B7533 (I.X) L.5.68 B7534 (I.X) L.5.69
B7535 (I.X) L.5.70 B7536 (I.X) L.5.71 B7537 (I.X) L.5.72 B7538
(I.X) L.5.73 B7539 (I.X) L.5.74 B7540 (I.X) L.5.75 B7541 (I.X)
L.5.76 B7542 (I.X) L.5.77 B7543 (I.X) L.5.78 B7544 (I.X) L.5.79
B7545 (I.X) L.5.80 B7546 (I.X) L.5.81 B7547 (I.X) L.5.82 B7548
(I.X) L.5.83 B7549 (I.X) L.5.84 B7550 (I.X) L.6.1 B7551 (I.X) L.6.2
B7552 (I.X) L.6.3 B7553 (I.X) L.6.4 B7554 (I.X) L.6.5 B7555 (I.X)
L.6.6 B7556 (I.X) L.6.7 B7557 (I.X) L.6.8 B7558 (I.X) L.6.9 B7559
(I.X) L.6.10 B7560 (I.X) L.6.11 B7561 (I.X) L.6.12 B7562 (I.X)
L.6.13 B7563 (I.X) L.6.14 B7564 (I.X) L.6.15 B7565 (I.X) L.6.16
B7566 (I.X) L.6.17 B7567 (I.X) L.6.18 B = Mixture; I = compound I;
II = compound II
TABLE-US-00025 TABLE 73 B I II B7568 (I.Y) L.1.1 B7569 (I.Y) L.1.2
B7570 (I.Y) L.1.3 B7571 (I.Y) L.1.4 B7572 (I.Y) L.1.5 B7573 (I.Y)
L.1.6 B7574 (I.Y) L.1.7 B7575 (I.Y) L.1.8 B7576 (I.Y) L.1.9 B7577
(I.Y) L.1.10 B7578 (I.Y) L.1.11 B7579 (I.Y) L.1.12 B7580 (I.Y)
L.1.13 B7581 (I.Y) L.1.14 B7582 (I.Y) L.1.15 B7583 (I.Y) L.1.16
B7584 (I.Y) L.1.17 B7585 (I.Y) L.1.18 B7586 (I.Y) L.1.19 B7587
(I.Y) L.1.20 B7588 (I.Y) L.1.21 B7589 (I.Y) L.1.22 B7590 (I.Y)
L.1.23 B7591 (I.Y) L.1.24 B7592 (I.Y) L.1.25 B7593 (I.Y) L.1.26
B7594 (I.Y) L.1.27 B7595 (I.Y) L.1.28 B7596 (I.Y) L.1.29 B7597
(I.Y) L.1.30 B7598 (I.Y) L.1.31 B7599 (I.Y) L.1.32 B7600 (I.Y)
L.1.33 B7601 (I.Y) L.1.34 B7602 (I.Y) L.1.35 B7603 (I.Y) L.1.36
B7604 (I.Y) L.1.37 B7605 (I.Y) L.1.38 B7606 (I.Y) L.1.39 B7607
(I.Y) L.1.40 B7608 (I.Y) L.1.41 B7609 (I.Y) L.1.42 B7610 (I.Y)
L.1.43 B7611 (I.Y) L.1.44 B7612 (I.Y) L.1.45 B7613 (I.Y) L.1.46
B7614 (I.Y) L.1.47 B7615 (I.Y) L.1.48 B7616 (I.Y) L.1.49 B7617
(I.Y) L.1.50 B7618 (I.Y) L.1.51 B7619 (I.Y) L.1.52 B7620 (I.Y)
L.1.53 B7621 (I.Y) L.1.54 B7622 (I.Y) L.1.55 B7623 (I.Y) L.1.56
B7624 (I.Y) L.1.57 B7625 (I.Y) L.1.58 B7626 (I.Y) L.1.59 B7627
(I.Y) L.1.60 B7628 (I.Y) L.1.61 B7629 (I.Y) L.1.62 B7630 (I.Y)
L.1.63 B7631 (I.Y) L.1.64 B7632 (I.Y) L.1.65 B7633 (I.Y) L.1.66
B7634 (I.Y) L.1.67 B7635 (I.Y) L.1.68 B7636 (I.Y) L.1.69 B7637
(I.Y) L.1.70 B7638 (I.Y) L.1.71 B7639 (I.Y) L.1.72 B7640 (I.Y)
L.1.73 B7641 (I.Y) L.1.74 B7642 (I.Y) L.1.75 B7643 (I.Y) L.1.76
B7644 (I.Y) L.1.77 B7645 (I.Y) L.1.78 B7646 (I.Y) L.1.79 B7647
(I.Y) L.1.80 B7648 (I.Y) L.1.81 B7649 (I.Y) L.1.82 B7650 (I.Y)
L.1.83 B7651 (I.Y) L.1.84 B7652 (I.Y) L.1.85 B7653 (I.Y) L.1.86
B7654 (I.Y) L.1.87 B7655 (I.Y) L.1.88 B7656 (I.Y) L.1.89 B7657
(I.Y) L.1.90 B7658 (I.Y) L.1.91 B7659 (I.Y) L.1.92 B7660 (I.Y)
L.1.93 B7661 (I.Y) L.1.94 B7662 (I.Y) L.1.95 B7663 (I.Y) L.1.96
B7664 (I.Y) L.2.1 B7665 (I.Y) L.2.2 B7666 (I.Y) L.2.3 B7667 (I.Y)
L.2.4 B7668 (I.Y) L.2.5 B7669 (I.Y) L.2.6 B7670 (I.Y) L.2.7 B7671
(I.Y) L.2.8 B7672 (I.Y) L.2.9 B7673 (I.Y) L.2.10 B7674 (I.Y) L.2.11
B7675 (I.Y) L.2.12 B7676 (I.Y) L.2.13 B7677 (I.Y) L.2.14 B7678
(I.Y) L.2.15 B7679 (I.Y) L.2.16 B7680 (I.Y) L.2.17 B7681 (I.Y)
L.2.18 B7682 (I.Y) L.2.19 B7683 (I.Y) L.2.20 B7684 (I.Y) L.2.21
B7685 (I.Y) L.2.22 B7686 (I.Y) L.2.23 B7687 (I.Y) L.2.24 B7688
(I.Y) L.2.25 B7689 (I.Y) L.2.26 B7690 (I.Y) L.2.27 B7691 (I.Y)
L.2.28 B7692 (I.Y) L.2.29 B7693 (I.Y) L.2.30 B7694 (I.Y) L.2.31
B7695 (I.Y) L.2.32 B7696 (I.Y) L.2.33 B7697 (I.Y) L.3.1 B7698 (I.Y)
L.3.2 B7699 (I.Y) L.3.3 B7700 (I.Y) L.3.4 B7701 (I.Y) L.3.5 B7702
(I.Y) L.3.6 B7703 (I.Y) L.3.7 B7704 (I.Y) L.3.8 B7705 (I.Y) L.3.9
B7706 (I.Y) L.3.10 B7707 (I.Y) L.3.11 B7708 (I.Y) L.3.12 B7709
(I.Y) L.3.13 B7710 (I.Y) L.3.14 B7711 (I.Y) L.3.15 B7712 (I.Y)
L.3.16 B7713 (I.Y) L.3.17 B7714 (I.Y) L.3.18 B7715 (I.Y) L.3.19
B7716 (I.Y) L.3.20 B7717 (I.Y) L.3.21 B7718 (I.Y) L.3.22 B7719
(I.Y) L.3.23 B7720 (I.Y) L.3.24 B7721 (I.Y) L.3.25 B7722 (I.Y)
L.3.26 B7723 (I.Y) L.3.27 B7724 (I.Y) L.3.28 B7725 (I.Y) L.3.29
B7726 (I.Y) L.3.30 B7727 (I.Y) L.3.31 B7728 (I.Y) L.3.32 B7729
(I.Y) L.3.33 B7730 (I.Y) L.3.34 B7731 (I.Y) L.3.35 B7732 (I.Y)
L.3.36 B7733 (I.Y) L.3.37 B7734 (I.Y) L.3.38 B7735 (I.Y) L.3.39
B7736 (I.Y) L.3.40 B7737 (I.Y) L.3.41 B7738 (I.Y) L.3.42 B7739
(I.Y) L.3.43 B7740 (I.Y) L.3.44 B7741 (I.Y) L.3.45 B7742 (I.Y)
L.3.46 B7743 (I.Y) L.3.47 B7744 (I.Y) L.3.48 B7745 (I.Y) L.3.49
B7746 (I.Y) L.3.50 B7747 (I.Y) L.3.51 B7748 (I.Y) L.3.52 B7749
(I.Y) L.3.53 B7750 (I.Y) L.3.54 B7751 (I.Y) L.3.55 B7752 (I.Y)
L.3.56 B7753 (I.Y) L.3.57 B7754 (I.Y) L.3.58 B7755 (I.Y) L.3.59
B7756 (I.Y) L.3.60 B7757 (I.Y) L.3.61 B7758 (I.Y) L.3.62 B7759
(I.Y) L.3.63 B7760 (I.Y) L.3.1 B7761 (I.Y) L.3.2 B7762 (I.Y) L.4.1
B7763 (I.Y) L.4.2 B7764 (I.Y) L.4.3 B7765 (I.Y) L.4.4 B7766 (I.Y)
L.4.5 B7767 (I.Y) L.4.6 B7768 (I.Y) L.4.7 B7769 (I.Y) L.4.8 B7770
(I.Y) L.4.9 B7771 (I.Y) L.4.10 B7772 (I.Y) L.4.11 B7773 (I.Y)
L.4.12 B7774 (I.Y) L.4.13 B7775 (I.Y) L.4.14 B7776 (I.Y) L.4.15
B7777 (I.Y) L.4.16 B7778 (I.Y) L.4.17 B7779 (I.Y) L.4.18 B7780
(I.Y) L.4.19 B7781 (I.Y) L.4.20 B7782 (I.Y) L.4.21 B7783 (I.Y)
L.4.22 B7784 (I.Y) L.4.23 B7785 (I.Y) L.4.24 B7786 (I.Y) L.4.25
B7787 (I.Y) L.4.26 B7788 (I.Y) L.4.27 B7789 (I.Y) L.4.28 B7790
(I.Y) L.4.29 B7791 (I.Y) L.4.30 B7792 (I.Y) L.4.31 B7793 (I.Y)
L.4.32 B7794 (I.Y) L.4.33 B7795 (I.Y) L.5.1 B7796 (I.Y) L.5.2 B7797
(I.Y) L.5.3 B7798 (I.Y) L.5.4 B7799 (I.Y) L.5.5 B7800 (I.Y) L.5.6
B7801 (I.Y) L.5.7 B7802 (I.Y) L.5.8 B7803 (I.Y) L.5.9 B7804 (I.Y)
L.5.10 B7805 (I.Y) L.5.11 B7806 (I.Y) L.5.12 B7807 (I.Y) L.5.13
B7808 (I.Y) L.5.14 B7809 (I.Y) L.5.15 B7810 (I.Y) L.5.16 B7811
(I.Y) L.5.17 B7812 (I.Y) L.5.18 B7813 (I.Y) L.5.19
B7814 (I.Y) L.5.20 B7815 (I.Y) L.5.21 B7816 (I.Y) L.5.22 B7817
(I.Y) L.5.23 B7818 (I.Y) L.5.24 B7819 (I.Y) L.5.25 B7820 (I.Y)
L.5.26 B7821 (I.Y) L.5.27 B7822 (I.Y) L.5.28 B7823 (I.Y) L.5.29
B7824 (I.Y) L.5.30 B7825 (I.Y) L.5.31 B7826 (I.Y) L.5.32 B7827
(I.Y) L.5.33 B7828 (I.Y) L.5.34 B7829 (I.Y) L.5.35 B7830 (I.Y)
L.5.36 B7831 (I.Y) L.5.37 B7832 (I.Y) L.5.38 B7833 (I.Y) L.5.39
B7834 (I.Y) L.5.40 B7835 (I.Y) L.5.41 B7836 (I.Y) L.5.42 B7837
(I.Y) L.5.43 B7838 (I.Y) L.5.44 B7839 (I.Y) L.5.45 B7840 (I.Y)
L.5.46 B7841 (I.Y) L.5.47 B7842 (I.Y) L.5.48 B7843 (I.Y) L.5.49
B7844 (I.Y) L.5.50 B7845 (I.Y) L.5.51 B7846 (I.Y) L.5.52 B7847
(I.Y) L.5.53 B7848 (I.Y) L.5.54 B7849 (I.Y) L.5.55 B7850 (I.Y)
L.5.56 B7851 (I.Y) L.5.57 B7852 (I.Y) L.5.58 B7853 (I.Y) L.5.59
B7854 (I.Y) L.5.60 B7855 (I.Y) L.5.61 B7856 (I.Y) L.5.62 B7857
(I.Y) L.5.63 B7858 (I.Y) L.5.64 B7859 (I.Y) L.5.65 B7860 (I.Y)
L.5.66 B7861 (I.Y) L.5.67 B7862 (I.Y) L.5.68 B7863 (I.Y) L.5.69
B7864 (I.Y) L.5.70 B7865 (I.Y) L.5.71 B7866 (I.Y) L.5.72 B7867
(I.Y) L.5.73 B7868 (I.Y) L.5.74 B7869 (I.Y) L.5.75 B7870 (I.Y)
L.5.76 B7871 (I.Y) L.5.77 B7872 (I.Y) L.5.78 B7873 (I.Y) L.5.79
B7874 (I.Y) L.5.80 B7875 (I.Y) L.5.81 B7876 (I.Y) L.5.82 B7877
(I.Y) L.5.83 B7878 (I.Y) L.5.84 B7879 (I.Y) L.6.1 B7880 (I.Y) L.6.2
B7881 (I.Y) L.6.3 B7882 (I.Y) L.6.4 B7883 (I.Y) L.6.5 B7884 (I.Y)
L.6.6 B7885 (I.Y) L.6.7 B7886 (I.Y) L.6.8 B7887 (I.Y) L.6.9 B7888
(I.Y) L.6.10 B7889 (I.Y) L.6.11 B7890 (I.Y) L.6.12 B7891 (I.Y)
L.6.13 B7892 (I.Y) L.6.14 B7893 (I.Y) L.6.15 B7894 (I.Y) L.6.16
B7895 (I.Y) L.6.17 B7896 (I.Y) L.6.18 B = Mixture; I = compound I;
II = compound II
TABLE-US-00026 TABLE 74 B I II B7897 (I.Z) L.1.1 B7898 (I.Z) L.1.2
B7899 (I.Z) L.1.3 B7900 (I.Z) L.1.4 B7901 (I.Z) L.1.5 B7902 (I.Z)
L.1.6 B7903 (I.Z) L.1.7 B7904 (I.Z) L.1.8 B7905 (I.Z) L.1.9 B7906
(I.Z) L.1.10 B7907 (I.Z) L.1.11 B7908 (I.Z) L.1.12 B7909 (I.Z)
L.1.13 B7910 (I.Z) L.1.14 B7911 (I.Z) L.1.15 B7912 (I.Z) L.1.16
B7913 (I.Z) L.1.17 B7914 (I.Z) L.1.18 B7915 (I.Z) L.1.19 B7916
(I.Z) L.1.20 B7917 (I.Z) L.1.21 B7918 (I.Z) L.1.22 B7919 (I.Z)
L.1.23 B7920 (I.Z) L.1.24 B7921 (I.Z) L.1.25 B7922 (I.Z) L.1.26
B7923 (I.Z) L.1.27 B7924 (I.Z) L.1.28 B7925 (I.Z) L.1.29 B7926
(I.Z) L.1.30 B7927 (I.Z) L.1.31 B7928 (I.Z) L.1.32 B7929 (I.Z)
L.1.33 B7930 (I.Z) L.1.34 B7931 (I.Z) L.1.35 B7932 (I.Z) L.1.36
B7933 (I.Z) L.1.37 B7934 (I.Z) L.1.38 B7935 (I.Z) L.1.39 B7936
(I.Z) L.1.40 B7937 (I.Z) L.1.41 B7938 (I.Z) L.1.42 B7939 (I.Z)
L.1.43 B7940 (I.Z) L.1.44 B7941 (I.Z) L.1.45 B7942 (I.Z) L.1.46
B7943 (I.Z) L.1.47 B7944 (I.Z) L.1.48 B7945 (I.Z) L.1.49 B7946
(I.Z) L.1.50 B7947 (I.Z) L.1.51 B7948 (I.Z) L.1.52 B7949 (I.Z)
L.1.53 B7950 (I.Z) L.1.54 B7951 (I.Z) L.1.55 B7952 (I.Z) L.1.56
B7953 (I.Z) L.1.57 B7954 (I.Z) L.1.58 B7955 (I.Z) L.1.59 B7956
(I.Z) L.1.60 B7957 (I.Z) L.1.61 B7958 (I.Z) L.1.62 B7959 (I.Z)
L.1.63 B7960 (I.Z) L.1.64 B7961 (I.Z) L.1.65 B7962 (I.Z) L.1.66
B7963 (I.Z) L.1.67 B7964 (I.Z) L.1.68 B7965 (I.Z) L.1.69 B7966
(I.Z) L.1.70 B7967 (I.Z) L.1.71 B7968 (I.Z) L.1.72 B7969 (I.Z)
L.1.73 B7970 (I.Z) L.1.74 B7971 (I.Z) L.1.75 B7972 (I.Z) L.1.76
B7973 (I.Z) L.1.77 B7974 (I.Z) L.1.78 B7975 (I.Z) L.1.79 B7976
(I.Z) L.1.80 B7977 (I.Z) L.1.81 B7978 (I.Z) L.1.82 B7979 (I.Z)
L.1.83 B7980 (I.Z) L.1.84 B7981 (I.Z) L.1.85 B7982 (I.Z) L.1.86
B7983 (I.Z) L.1.87 B7984 (I.Z) L.1.88 B7985 (I.Z) L.1.89 B7986
(I.Z) L.1.90 B7987 (I.Z) L.1.91 B7988 (I.Z) L.1.92 B7989 (I.Z)
L.1.93 B7990 (I.Z) L.1.94 B7991 (I.Z) L.1.95 B7992 (I.Z) L.1.96
B7993 (I.Z) L.2.1 B7994 (I.Z) L.2.2 B7995 (I.Z) L.2.3 B7996 (I.Z)
L.2.4 B7997 (I.Z) L.2.5 B7998 (I.Z) L.2.6 B7999 (I.Z) L.2.7 B8000
(I.Z) L.2.8 B8001 (I.Z) L.2.9 B8002 (I.Z) L.2.10 B8003 (I.Z) L.2.11
B8004 (I.Z) L.2.12 B8005 (I.Z) L.2.13 B8006 (I.Z) L.2.14 B8007
(I.Z) L.2.15 B8008 (I.Z) L.2.16 B8009 (I.Z) L.2.17 B8010 (I.Z)
L.2.18 B8011 (I.Z) L.2.19 B8012 (I.Z) L.2.20 B8013 (I.Z) L.2.21
B8014 (I.Z) L.2.22 B8015 (I.Z) L.2.23 B8016 (I.Z) L.2.24 B8017
(I.Z) L.2.25 B8018 (I.Z) L.2.26 B8019 (I.Z) L.2.27 B8020 (I.Z)
L.2.28 B8021 (I.Z) L.2.29 B8022 (I.Z) L.2.30 B8023 (I.Z) L.2.31
B8024 (I.Z) L.2.32 B8025 (I.Z) L.2.33 B8026 (I.Z) L.3.1 B8027 (I.Z)
L.3.2 B8028 (I.Z) L.3.3 B8029 (I.Z) L.3.4 B8030 (I.Z) L.3.5 B8031
(I.Z) L.3.6 B8032 (I.Z) L.3.7 B8033 (I.Z) L.3.8 B8034 (I.Z) L.3.9
B8035 (I.Z) L.3.10 B8036 (I.Z) L.3.11 B8037 (I.Z) L.3.12 B8038
(I.Z) L.3.13 B8039 (I.Z) L.3.14 B8040 (I.Z) L.3.15 B8041 (I.Z)
L.3.16 B8042 (I.Z) L.3.17 B8043 (I.Z) L.3.18 B8044 (I.Z) L.3.19
B8045 (I.Z) L.3.20 B8046 (I.Z) L.3.21 B8047 (I.Z) L.3.22 B8048
(I.Z) L.3.23 B8049 (I.Z) L.3.24 B8050 (I.Z) L.3.25 B8051 (I.Z)
L.3.26 B8052 (I.Z) L.3.27 B8053 (I.Z) L.3.28 B8054 (I.Z) L.3.29
B8055 (I.Z) L.3.30 B8056 (I.Z) L.3.31 B8057 (I.Z) L.3.32 B8058
(I.Z) L.3.33 B8059 (I.Z) L.3.34 B8060 (I.Z) L.3.35 B8061 (I.Z)
L.3.36 B8062 (I.Z) L.3.37 B8063 (I.Z) L.3.38 B8064 (I.Z) L.3.39
B8065 (I.Z) L.3.40 B8066 (I.Z) L.3.41 B8067 (I.Z) L.3.42 B8068
(I.Z) L.3.43 B8069 (I.Z) L.3.44 B8070 (I.Z) L.3.45 B8071 (I.Z)
L.3.46 B8072 (I.Z) L.3.47 B8073 (I.Z) L.3.48 B8074 (I.Z) L.3.49
B8075 (I.Z) L.3.50 B8076 (I.Z) L.3.51 B8077 (I.Z) L.3.52 B8078
(I.Z) L.3.53 B8079 (I.Z) L.3.54 B8080 (I.Z) L.3.55 B8081 (I.Z)
L.3.56 B8082 (I.Z) L.3.57 B8083 (I.Z) L.3.58 B8084 (I.Z) L.3.59
B8085 (I.Z) L.3.60 B8086 (I.Z) L.3.61 B8087 (I.Z) L.3.62 B8088
(I.Z) L.3.63 B8089 (I.Z) L.3.1 B8090 (I.Z) L.3.2 B8091 (I.Z) L.4.1
B8092 (I.Z) L.4.2 B8093 (I.Z) L.4.3 B8094 (I.Z) L.4.4 B8095 (I.Z)
L.4.5 B8096 (I.Z) L.4.6 B8097 (I.Z) L.4.7 B8098 (I.Z) L.4.8 B8099
(I.Z) L.4.9 B8100 (I.Z) L.4.10 B8101 (I.Z) L.4.11 B8102 (I.Z)
L.4.12 B8103 (I.Z) L.4.13 B8104 (I.Z) L.4.14 B8105 (I.Z) L.4.15
B8106 (I.Z) L.4.16 B8107 (I.Z) L.4.17 B8108 (I.Z) L.4.18 B8109
(I.Z) L.4.19 B8110 (I.Z) L.4.20 B8111 (I.Z) L.4.21 B8112 (I.Z)
L.4.22 B8113 (I.Z) L.4.23 B8114 (I.Z) L.4.24 B8115 (I.Z) L.4.25
B8116 (I.Z) L.4.26 B8117 (I.Z) L.4.27 B8118 (I.Z) L.4.28 B8119
(I.Z) L.4.29 B8120 (I.Z) L.4.30 B8121 (I.Z) L.4.31 B8122 (I.Z)
L.4.32 B8123 (I.Z) L.4.33 B8124 (I.Z) L.5.1 B8125 (I.Z) L.5.2 B8126
(I.Z) L.5.3 B8127 (I.Z) L.5.4 B8128 (I.Z) L.5.5 B8129 (I.Z) L.5.6
B8130 (I.Z) L.5.7 B8131 (I.Z) L.5.8 B8132 (I.Z) L.5.9 B8133 (I.Z)
L.5.10 B8134 (I.Z) L.5.11 B8135 (I.Z) L.5.12 B8136 (I.Z) L.5.13
B8137 (I.Z) L.5.14 B8138 (I.Z) L.5.15 B8139 (I.Z) L.5.16 B8140
(I.Z) L.5.17 B8141 (I.Z) L.5.18 B8142 (I.Z) L.5.19
B8143 (I.Z) L.5.20 B8144 (I.Z) L.5.21 B8145 (I.Z) L.5.22 B8146
(I.Z) L.5.23 B8147 (I.Z) L.5.24 B8148 (I.Z) L.5.25 B8149 (I.Z)
L.5.26 B8150 (I.Z) L.5.27 B8151 (I.Z) L.5.28 B8152 (I.Z) L.5.29
B8153 (I.Z) L.5.30 B8154 (I.Z) L.5.31 B8155 (I.Z) L.5.32 B8156
(I.Z) L.5.33 B8157 (I.Z) L.5.34 B8158 (I.Z) L.5.35 B8159 (I.Z)
L.5.36 B8160 (I.Z) L.5.37 B8161 (I.Z) L.5.38 B8162 (I.Z) L.5.39
B8163 (I.Z) L.5.40 B8164 (I.Z) L.5.41 B8165 (I.Z) L.5.42 B8166
(I.Z) L.5.43 B8167 (I.Z) L.5.44 B8168 (I.Z) L.5.45 B8169 (I.Z)
L.5.46 B8170 (I.Z) L.5.47 B8171 (I.Z) L.5.48 B8172 (I.Z) L.5.49
B8173 (I.Z) L.5.50 B8174 (I.Z) L.5.51 B8175 (I.Z) L.5.52 B8176
(I.Z) L.5.53 B8177 (I.Z) L.5.54 B8178 (I.Z) L.5.55 B8179 (I.Z)
L.5.56 B8180 (I.Z) L.5.57 B8181 (I.Z) L.5.58 B8182 (I.Z) L.5.59
B8183 (I.Z) L.5.60 B8184 (I.Z) L.5.61 B8185 (I.Z) L.5.62 B8186
(I.Z) L.5.63 B8187 (I.Z) L.5.64 B8188 (I.Z) L.5.65 B8189 (I.Z)
L.5.66 B8190 (I.Z) L.5.67 B8191 (I.Z) L.5.68 B8192 (I.Z) L.5.69
B8193 (I.Z) L.5.70 B8194 (I.Z) L.5.71 B8195 (I.Z) L.5.72 B8196
(I.Z) L.5.73 B8197 (I.Z) L.5.74 B8198 (I.Z) L.5.75 B8199 (I.Z)
L.5.76 B8200 (I.Z) L.5.77 B8201 (I.Z) L.5.78 B8202 (I.Z) L.5.79
B8203 (I.Z) L.5.80 B8204 (I.Z) L.5.81 B8205 (I.Z) L.5.82 B8206
(I.Z) L.5.83 B8207 (I.Z) L.5.84 B8208 (I.Z) L.6.1 B8209 (I.Z) L.6.2
B8210 (I.Z) L.6.3 B8211 (I.Z) L.6.4 B8212 (I.Z) L.6.5 B8213 (I.Z)
L.6.6 B8214 (I.Z) L.6.7 B8215 (I.Z) L.6.8 B8216 (I.Z) L.6.9 B8217
(I.Z) L.6.10 B8218 (I.Z) L.6.11 B8219 (I.Z) L.6.12 B8220 (I.Z)
L.6.13 B8221 (I.Z) L.6.14 B8222 (I.Z) L.6.15 B8223 (I.Z) L.6.16
B8224 (I.Z) L.6.17 B8225 (I.Z) L.6.18 B = Mixture; I = compound I;
II = compound II
[0349] Table 75: The binary mixtures A8500 to A8827 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AA.
[0350] Table 76: The binary mixtures A9000 to A9327 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AB.
[0351] Table 77: The binary mixtures A9500 to A9827 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AC.
[0352] Table 78: The binary mixtures A10000 to A10327 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AD.
[0353] Table 79: The binary mixtures A10500 to A10827 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AE.
[0354] Table 80: The binary mixtures A11000 to A11327 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AF.
[0355] Table 81: The binary mixtures A11500 to A11827 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AG.
[0356] Table 82: The binary mixtures A12000 to A12327 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AH.
[0357] Table 83: The binary mixtures A12500 to A12827 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AI.
[0358] Table 84: The binary mixtures A13000 to A13327 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AJ.
[0359] Table 85: The binary mixtures A13500 to A13827 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AK.
[0360] Table 86: The binary mixtures A14000 to A14327 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AL.
[0361] Table 87: The binary mixtures A14500 to A14827 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AM.
[0362] Table 88: The binary mixtures A15000 to A15327 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AN.
[0363] Table 89: The binary mixtures A15500 to A15827 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AO.
[0364] Table 90: The binary mixtures A16000 to A16327 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AP.
[0365] Table 91: The binary mixtures A16500 to A16827 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AQ.
[0366] Table 92: The binary mixtures A17000 to A17327 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AR.
[0367] Table 93: The binary mixtures A17500 to A17827 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AS.
[0368] Table 94: The binary mixtures A18000 to A18327 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AT.
[0369] Table 95: The binary mixtures A18500 to A18827 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AU.
[0370] Table 96: The binary mixtures A19000 to A19327 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AV.
[0371] Table 97: The binary mixtures A19500 to A19827 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AW.
[0372] Table 98: The binary mixtures A20000 to A20327 correspond to
the mixtures B1 to B328, wherein compound I.A is replaced by
compound I.AX.
[0373] Among the mixtures of tables 50 to 98, the mixtures
comprising L.1.1, L.1.7, L.1.2, L.1.13, L.1.14, L.1.15, L.1.16,
L.1.17, L.1.19, L.1.23, L.1.25, L.1.26, L.1.30, L.1.32, L.1.34,
L.1.36, L.1.38, L.1.40, L.1.41, L.1.43, L.1.44, L.1.48, L.1.49,
L.1.51, L.1.52, L.1.53, L.1.54, L.1.57, L.1.59, L.1.60, L.1.63,
L.1.66, L.1.68, L.1.70, L.1.72, L.1.75, L.1.76, L.1.77, L.1.78,
L.1.79, L.1.80, L.1.81, L.1.82, L.1.83, L.1.85, L.1.87, L.1.91,
L.1.92, L.1.93 or L.1.96 are preferred mixtures according to the
invention.
[0374] Among the mixtures of tables 50 to 98, the mixtures
comprising L.2.1, L.2.2 or L.2.8 are preferred mixtures according
to the invention.
[0375] Among the mixtures of tables 50 to 98, the mixtures
comprising L.3.3, L.3.18, L.3.20, L.3.21, L.3.28, L.3.30, L.3.32,
L.3.39, L.3.41, L.3.46, L.3.54, L.3.55, L.3.58, L.3.61, L.3.62 or
L.3.63 are preferred mixtures according to the invention.
[0376] Among the mixtures of tables 50 to 98, the mixtures
comprising L.4.9, L.4.13, L.4.31 or L.4.29 are preferred mixtures
according to the invention.
[0377] Among the mixtures of tables 50 to 98, the mixtures
comprising L.5.4, L.5.12, L.5.13, L.5.16, L.5.17, L.5.41, L.5.48,
L.5.9, L.5.10, L.5.16, L.5.17, L.5.24, L.5.26, L.5.27, L.5.28,
L.5.35, L.5.37, L.5.38, L.5.42, L.5.47, L.5.52, L.5.58, L.5.63,
L.5.64, L.5.65, L.5.66, L.5.71, L.5.72, L.5.73, L.5.76, L.5.78,
L.5.79, L.5.80, L.5.81, L.5.82, L.5.83 or L.5.84 are preferred
mixtures according to the invention.
[0378] Among the mixtures of tables 50 to 98, the mixtures
comprising L.6.10 or L.6.17 are preferred mixtures according to the
invention.
[0379] The biopesticides from group L1) and/or L2) may also have
insecticidal, acaricidal, molluscidal, pheromone, nematicidal,
plant stress reducing, plant growth regulator, plant growth
promoting and/or yield enhancing activity.
[0380] The biopesticides from group L3) and/or L4) may also have
fungicidal, bactericidal, viricidal, plant defense activator, plant
stress reducing, plant growth regulator, plant growth promoting
and/or yield enhancing activity.
[0381] The biopesticides from group L5) and/or L6) may also have
fungicidal, bactericidal, viricidal, plant defense activator,
insecticidal, acaricidal, molluscidal, pheromone and/or nematicidal
activity.
[0382] Many of these biopesticides have been deposited under
deposition numbers mentioned herein (the prefaces refer to the
acronym of the respective culture collection), are referred to in
literature, registered and/or are commercially available: aluminium
silicate (Screen.TM. Duo from Certis LLC, USA), Agrobacterium
radiobacter K1026 (e.g. NoGall.RTM. from BASF Agricultural
Specialties Pty Ltd, Australia), A. radiobacter K84 (Nature 280,
697-699, 1979; e.g. GallTroll.RTM. from AG Biochem, Inc., C, USA),
Ampelomyces quisqualis M-10 (e.g. AQ 10.RTM. from Intrachem Bio
GmbH & Co. KG, Germany), Ascophyllum nodosum (Norwegian kelp,
Brown kelp) extract or filtrate (e.g. ORKA GOLD from BASF
Agricultural Specialities (Pty) Ltd., South Africa; or Goemar.RTM.
from Laboratoires Goemar, France), Aspergillus flavus NRRL 21882
isolated from a peanut in Georgia in 1991 by USDA, National Peanut
Research Laboratory (e.g. in Afla-Guard.RTM. from Syngenta, CH),
mixtures of Aureobasidium pullulans DSM14940 and DSM 14941 (e.g.
blastospores in Blossom Protect.RTM. from bio-ferm GmbH, Germany),
Azospirillum amazonense SpY2 (DN: BR 11140; Proc. 9.sup.th Int. and
1.sup.st Latin American PGPR meeting, Quimara, Medellin, Colombia
2012, p. 60, ISBN 978-958-46-0908-3), A. brasilense AZ39 (also
called Az 39; INTA Az-39; Eur. J. Soil Biol 45(1), 28-35, 2009), A.
brasilense XOH (e.g. AZOS from Xtreme Gardening, USA or RTI
Reforestation Technologies International; USA), A. brasilense BR
11002 (Proc. 9.sup.th Int. and 1.sup.st Latin American PGPR
meeting, Quimara, Medellin, Colombia 2012, p. 60, ISBN
978-958-46-0908-3), A. brasilense Sp245 (BR 11005; e.g. in GELFIX
Gramineas from BASF Agricultural Specialties Ltd., Brazil), A.
brasilense strains Ab-V5 and Ab-V6 (e.g. in AzoMax from Novozymes
BioAg Produtos papra Agricultura Ltda., Quattro Barras, Brazil or
SimbioseMaiz.RTM. from Simbiose-Agro, Cruz Alta, RS, Brazil; Plant
Soil 331, 413-425, 2010), A. lipoferum BR 11646 (Sp31) (Proc.
9.sup.th Int. and 1.sup.st Latin American PGPR meeting, Quimara,
Medellin, Colombia 2012, p. 60), Bacillus altitudinis 41KF2b (DSM
21631; Int. J. Syst. Evol. Microbiol. 56(7), 1465-1473, 2006),
Bacillus amyloliquefaciens strains AP-136 (NRRL B-50614 and
B-50330), AP-188 (NRRL B-50615 and B-50331), AP-218 (NRRL B-50618),
AP-219 (NRRL B-50619 and B-50332), and AP-295 (NRRL B-50620 and
B-50333) all known from U.S. Pat. No. 8,445,255; B.
amyloliquefaciens IT-45 (CNCM I-3800) (e.g. Rhizocell C from ITHEC,
France), B. amyloliquefaciens IN937a (J. Microbiol. Biotechnol.
17(2), 280-286, 2007; e.g. BioYield.RTM. from Gustafson LLC, TX,
USA), B. amyloliquefaciens spp. plantarum D747 (US 20130236522 A1;
FERM BP-8234; e.g. Double Nickel.TM. 55 WDG or Double Nickel.TM. LC
from Certis LLC, USA), B. amyloliquefaciens spp. plantarum FZB24
isolated from plant pathogen-infested soil of a sugar beet field in
Brandenburg, Germany (also called SB3615; DSM ID 96-2; J. Plant
Dis. Prot. 105, 181-197, 1998; e.g. Taegro.RTM. from Novozyme
Biologicals, Inc., USA),), B. amyloliquefaciens spp. plantarum
SB3615vPPI being a phage-resistant variant of FZB24 (MRRL B-50349;
US 2011/023045 A1; from Novozyme Biologicals, Inc., USA), B.
amyloliquefaciens ssp. plantarum FZB42 isolated from plant
pathogen-infested soil of a sugar beet field in Brandenburg,
Germany (J. Plant Dis. Prot. 105, 181-197, 1998; DSM 23117; e.g.
RhizoVital.RTM. 42 from AbiTEP GmbH, Berlin, Germany), B.
amyloliquefaciens ssp. plantarumGB03 (also called GBO3; ATCC
SD-1397; Phytopathol. 86(11), S36, 1996; e.g. Kodiak.RTM. or
BioYield.RTM. from Gustafson, Inc., USA; or Companion.RTM. from
Growth Products, Ltd., White Plains, N.Y. 10603, USA), B.
amyloliquefaciens ssp. plantarum M B1600 also referred to as 1430
(NRRL B-50595; Int. J. Microbiol. Res. 3(2) (2011), 120-130; US
2012/0149571 A1; e.g. Integral.RTM., Subtilex.RTM. NG from BASF
Corp., USA), B. amyloliquefaciens spp. plantarum TJ1000 (also
called 1 BE; CA 2471555 A1; ATCC BAA-390; e.g. QuickRoots.TM. from
TJ Technologies, Watertown, S. Dak., USA), B. cereus CNCM I-1562
(U.S. Pat. No. 6,406,690), B. chitinosporus AQ746 isolated from
roots in Saskatchewan, Canada (NRRL B-21618; U.S. Pat. No.
5,733,544; AgraQuest now Bayer CropScience LP, USA), B. firmus CNCM
I-1582 (WO2009/126473, WO2009/124707, U.S. Pat. No. 6,406,690; e.g.
Votivo.RTM. from Bayer CropScience LP, USA), Bacillus licheniformis
strain RTI184 deposited as ATCC No. PTA-121722 and Bacillus
licheniformis CH200 deposited as Accession No. DSM 17236 (known
from US 2014/870,477 from FMC Corporation, Philadelphia (USA)),
Bacillus licheniformis strain SB3086 having the ATCC Deposit No.
55406 (known from U.S. Ser. No. 10/043,297 from Novozymes, USA.),
B. megaterium strains H491 (NRRL B-50769), M018 (NRRL B-50770) and
J142 (NRRL B-50771) all known from US 2014/0051571 A1 from Marrone
BioInnovations, Inc., USA; B. mojavensis AP-209 (NRRL B-50616; U.S.
Pat. No. 8,445,255), B. mycoides AQ726 (NRRL B-21664; U.S. Pat. No.
5,906,818; from Bayer Crop Science, Germany), B. mycoides strain J
(e.g. BmJ WG from Certis, USA against potato virus Y), B. pumilus
GB34 (ATCC 700814; e.g. YieldShield.RTM. from Gustafson LLC, TX,
USA), B. pumilus GHA 180 isolated from apple tree rhizosphere in
Mexico (IDAC 260707-01; e.g. in PRO-MIX.RTM. BX from Premier
Horticulture, 1, avenue Premier, Rivie're-du-Loup, Quebec, Canada
G5R6C1), B. pumilus KFP9F (NRRL B-50754; WO2014/029697; e.g. BAC-UP
or FUSION--P from BASF Agricultural Specialities (Pty) Ltd., South
Africa), B. pumilus INR-7 otherwise referred to as BU-F22 and
BU-F33 (NRRL B-50185, NRRL B-50153; U.S. Pat. No. 8,445,255), B.
pumilus QST 2808 (NRRL B-30087; e.g. Sonata.RTM. or Ballad.RTM.
Plus from AgraQuest Inc., USA), B. solisalsi AP-217 (NRRL B-50617;
U.S. Pat. No. 8,445,255), B. subtilis CX-9060 (Federal Register
77(7), 1633-1637; by Certis U.S.A., L.L.C.), B. subtilis FB17 also
called UD 1022 or UD10-22 isolated from red beet roots in North
America (ATCC PTA-11857; System. Appl. Microbiol. 27, 372-379,
2004; US 2010/0260735; WO 2011/109395); B. subtilis GB07
(Phytopathol. 86(11), S36, 1996; Epic.RTM. from Gustafson, Inc.,
USA), B. subtilis QST-713 isolated from a California peach orchard
in 1995 (NRRL B-21661; e.g. Rhapsody.RTM., Serenade.RTM. MAX or
Serenade.RTM. ASO from AgraQuest Inc., USA), B. thuringiensis ssp.
aizawai ABTS-1857 (also called ABG-6346; ATCC SD-1372; e.g.
XenTari.RTM. from BioFa AG, Munsingen, Germany), B. t. ssp. aizawai
SAN 401 I, ABG-6305 (WO 2013/087709); Bacillus t. ssp. israelensis
AM65-52 of Serotype H-14 (ATCC SD-1276; e.g. VectoBac.RTM. from
Valent BioSciences, IL, USA), Bacillus thuringiensis ssp. kurstaki
SB4 (NRRL B-50753; e.g. Beta Pro.RTM. from BASF Agricultural
Specialities (Pty) Ltd., South Africa), B. t. ssp. kurstaki
ABTS-351 identical to HD-1 (ATCC SD-1275; e.g. Dipel.RTM. DF from
Valent BioSciences, IL, USA), B. t. ssp. kurstaki EG 2348 (NRRL
B-18208; e.g. Lepinox.RTM. or Rapax.RTM. from CBC (Europe) S.r.I.,
Italy), B. t. ssp. tenebrionis DSM 2803 of Serotype H 8a, 8b
(identical to NRRL B-15939; EP 0 585 215 B1; Mycogen Corp.), B. t.
ssp. tenebrionis NB-125 (also referred to as SAN 418 I or ABG-6479;
EP 0 585 215 B1; DSM 5526; former production strain of
Novo-Nordisk), B. t. ssp. tenebrionis NB-176 (or NB-176-1; a
gamma-irradiated, induced high-yielding mutant of strain NB-125; EP
585 215 B1; DSM 5480; e.g. Novodor.RTM. from Valent BioSciences,
Switzerland), Beauveria bassiana JW-1 (ATCC 74040; e.g.
Naturalis.RTM. from CBC (Europe) S.r.I., Italy), B. bassiana DSM
12256 (US 200020031495; e.g. BioExpert.RTM. SC from Live Sytems
Technology S.A., Colombia), B. bassiana GHA (ATCC 74250; e.g.
BotaniGard.RTM. 22WGP from Laverlam Int. Corp., USA), B. bassiana
PPRI 5339 (ARSEF 5339; NRRL 50757; e.g. BroadBand.RTM. from BASF
Agricultural Specialities (Pty) Ltd., South Africa), B.
brongniartii for control of cockchafer (J. Appl. Microbiol.
100(5),1063-72, 2006; e.g. Melocont.RTM. from Agrifutur,
Agrianello, Italy), Bradyrhizobium sp. (e.g. Vault.RTM. from BASF
Corp., USA), B. sp. (Arachis) CB1015 presumably originally
collected in India (IITA 1006, USDA 3446; from Australian
Inoculants Research Group;
http://www.gaseeds.com.au/inoculant_applic.php). B. sp. (Arachis)
strains deposited at SEMIA and known from FEMS Microbiol. Letters
303(2), 123-131, 2010; Revista Brasileira de Ciencia do Solo 35(3),
739-742, 2011, ISSN 0100-0683: SEMIA 6144, SEMIA 6462 (BR 3267) and
SEMIA 6464 (BR 3262); B. sp. (Vigna) PNL01 (Bisson and Mason, Apr.
29, 2010, Project report, Worcester Polytechnic Institute,
Worcester, Mass., USA:
http://www.wpi.edu/Pubs/E-project/Available/E-project-042810-163614/;
e.g. Vault.RTM. Peanut Liquid from BASF Corp., USA), B. elkanii
SEMIA 587 (Appl. Environ. Microbiol. 73(8), 2635, 2007; e.g. GELFIX
5 from BASF Agricultural Specialties Ltd., Brazil), B. elkanii
SEMIA 5019 (=29W; Appl. Environ. Microbiol. 73(8), 2635, 2007; e.g.
GELFIX 5 from BASF Agricultural Specialties Ltd., Brazil), B.
elkanii USDA 76, B. elkanii USDA 94, B. elkanii USDA 3254, B.
elkanii U-1301 and U-1302 (e.g. Nitragin.RTM. Optimize from
Novozymes Bio As S.A., Brazil, or Nlitrasec for soybean from LAGE y
Cia, Brazil), B. japonicum (e.g. VAULT.RTM. from BASF Corp., USA),
B. japonicum 532c isolated from Wisconsin field (Nitragin 61A152;
Can. J. Plant. Sci. 70, 661-666, 1990; e.g. in Rhizoflo.RTM.,
Histick.RTM., Hicoat.RTM. Super from BASF Agricultural Specialties
Ltd., Canada), B. japonicum E-109 variant of strain USDA 138 (INTA
E109, SEMIA 5085; Eur. J. Soil Biol. 45, 28-35, 2009; Biol. Fertil.
Soils 47, 81-89, 2011), B. japonicumG49 (MSDJ G49; C. R. Acad.
Agric. Fr. 73, 163-171, 1987); B. japonicum strains deposited at
SEMIA known from Appl. Environ. Microbiol. 73(8), 2635, 2007: SEMIA
566 isolated from North American inoculant in 1966 and used in
Brazilian commercial inoculants from 1966 to 1978, SEMIA 586
originally isolated in Maryland, USA, in 1961 but received from
Australia in 1966 and used in Brazilian inoculants in 1977 (CB
1809, USDA 136, Nitragin 61A136, RCR 3407), SEMIA 5079 a natural
variant of SEMIA 566 used in commercial inoculants since 1992 (CPAC
15; e.g. GELFIX 5 or ADHERE 60 from BASF Agricultural Specialties
Ltd., Brazil), B. japonicum SEMIA 5080 a natural variant of SEMIA
586 used in commercial inoculants since 1992 (CPAC 7; e.g. GELFIX 5
or ADHERE 60 from BASF Agricultural Specialties Ltd., Brazil); B.
japonicum TA-11 (TA11 NOD*) (NRRL B-18466; U.S. Pat. No. 5,021,076;
Appl. Environ. Microbiol. 56, 2399-2403, 1990; e.g. VAULT.RTM. NP,
from BASF Corp., USA), B. japonicum strains deposited at USDA known
from U.S. Pat. No. 7,262,151 and Appl. Environ. Microbiol. 60,
940-94, 1994: USDA 3 isolated from Glycine max in Virginia (USA) in
1914, USDA 31 (=Nitragin 61A164) od Serogroup 31 isolated from
Glycine max in Wisconsin (USA) in 1941, USDA 76 isolated from plant
passage of strain USDA 74 (Serogroup 76) which has been isolated
from G. max in California (USA) in 1956, USDA 110 (=IITA 2121,
SEMIA 5032, RCR 3427, ARS 1-110 and Nitragin 61A89; Serogroup 110)
isolated from G. max in Florida in 1959, USDA 121 isolated from G.
max in Ohio (USA) in 1965 (Crop Science 26(5), 911-916, 1986); B.
japonicum WB74 (e.g. Eco-Rhiz Soya from Plant Health Products (Pty)
Ltd, South Africa; or Soybean inoculant from Stimuplant CC, South
Africa), B. lupini LL13 isolated from Lupinus luteus nodules from
French soils (deposited at INRA, France;
http://agriculture.gouv.fr/IMG/pdf/ch20060216.pdf), B. lupini
strains from Australia and known from Palta J. A., Berger J. B.
(eds), Proceed. 12th International Lupin Conference, 14-18 Sep.
2008, Fremantle, Western Australia, International Lupin
Association, Canterbury, New Zealand, 47-50,
http://www.lupins.org/pdf/conference/2008/Agronomy%20and%20Product-
ion/John%20Howieson%20and%20G%20OHara.pdf; Appl. Environ.
Microbiol. 71, 7041-7052, 2005; Australian J. Exp. Agricult. 36(1),
63-70, 1996: strains WU425 isolated in Esperance, Western Australia
from a non-Australian legume Ornithopus compressus, WSM471 isolated
from Ornithopus pinnatus in Oyster Harbour, Western Australia, and
WSM4024 isolated from lupins in Australia by CRS during a 2005
survey; Burkholderiasp. A396 (NRRL B-50319; WO 2013/032693; Marrone
Bio Innovations, Inc., USA), Candida oleophila I-182 (NRRL Y-18846;
Phytoparasitica 23(3), 231-234, 1995; e.g. Aspire.RTM. from Ecogen
Inc., USA;), C. oleophila strain 0 (NRRL Y-2317; Biological Control
51, 403-408, 2009), Candida saitoana (e.g. Biocure.RTM. [in mixture
with lysozyme] and BioCoat.RTM. from Micro Flo Company, USA (BASF
SE) and Arysta), chitosan (e.g. Armour-Zen.RTM. from BotriZen Ltd.,
NZ), Clonostachys rosea f. catenulate (also named Gliocladium
catenulatum) J1446 isolated from Finnish field soil (NJF seminar No
389: Pest, disease and weed management in strawberry; Finland 8-9.
November 2006 in NJF Report 2(10), 15-15, 2006; DSM 9212; e.g.
Primastop.RTM. or Prestop.RTM. from Verdera Oy, Finland),
Chromobacterium subtsugae PRAA4-1 isolated from soil under an
eastern hemlock (Tsuga canadensis) in the Catoctin Mountain region
of central Maryland (NRRL B-30655; e.g. Grandevo.RTM. from Marrone
Bio Innovations, USA), Coniothyrium minitans CON/M/91-08
(WO1996/021358; DSM 9660; e.g. Contans.RTM. WG, Intercept.RTM. WG
from Prophyta Biologischer Pflanzenschutz GmbH, Germany),
Cryphonectria parasitica (hypovirulent strains; Microbiol. Reviews
56(4), 561-576, 1992; e.g. product Endothia parasitica from CNICM,
France), Cryptococcus albidus (e.g. YIELD PLUS.RTM. from Anchor
Bio-Technologies, South Africa), Cryptophlebia leucotreta
granulovirus (CrleGV) (e.g. CRYPTEX from Adermatt Biocontrol,
Switzerland), Cydia pomonella granulovirus (CpGV) V03 (DSM GV-0006;
e.g. Madex.RTM. Max from Andermatt Biocontrol, Switzerland), CpGV
V22 (DSM GV-0014; e.g. Madex.RTM. Twin from Adermatt Biocontrol,
Switzerland), Delftia acidovorans RAY209 (ATCC PTA-4249; WO
2003/57861; e.g. BioBoost.RTM. from Brett Young, Winnipeg, Canada),
Dilophosphora alopecuri (FarmNote 396, February 2010, Department of
Agriculture and Food, Government of Western Australia; e.g. Twist
Fungus from BASF Agricultural Specialties Pty Ltd, Australia),
Ecklonia maxima (kelp) extract (J. Ecological Engineering 14(1),
48-52, 2013; e.g. KELPAK SL from Kelp Products Ltd, South Africa),
Flavobacterium sp. H492 (ATCC B-505584; WO 2013/138398; e.g.
MBI-302 from Marrone Bio Innovations, USA for soybean cyst nematode
control), formononetin (U.S. Pat. No. 5,002,603; e.g. Myconate.RTM.
from Plant Health Care plc, U.K.), Fusarium oxysporum Fo47
(non-pathogenic strain isolated from a suppressive soil located at
Chateaurenard, France; Appl. Environ. Microbiol 68(8), 4044-4060,
2002; Fusaclean.RTM. from Natural Plant Protection, N.P.P. (societe
anonyme) Route d'Artix F-64150 Nogueres, France), F. oxysporum
251/2RB (Prevention Today Vol. 2, n. 1-2, 47-62, 2006; e.g.
Biofox.RTM. C from S.I.A.P.A., Italy); Glomus intraradices
(e.g. Myc.RTM. 4000 from ITHEC, France), Glomus intraradices
RTI-801 (e.g. MYKOS from Xtreme Gardening, USA or RTI Reforestation
Technologies International; USA), grapefruit seeds and pulp extract
(e.g. BC-1000 from Chemie S.A., Chile), harpin (alpha-beta) protein
(Science 257, 85-88, 1992; e.g. Messenger.TM. or HARPN-Tek from
Plant Health Care plc, U.K.), Helicoverpa armigera
nucleopolyhedrovirus (HearNPV) (J. Invertebrate Pathol. 107,
112-126, 2011; e.g. Helicovex.RTM. from Adermatt Biocontrol,
Switzerland), Heterorhabditis bacteriophora (e.g. Nemasys.RTM. G
from BASF Agricultural Specialities Limited, UK), Isaria
fumosorosea Apopka-97 (ATCC 20874; Biocontrol Science Technol.
22(7), 747-761, 2012; e.g. PFR-97.TM. or PreFeRal.RTM. from Certis
LLC, USA), I. fumosorosea FE 9901 (ARSEF 4490; Biocontrol Science
Technol. 22(7), 747-761, 2012; e.g. blastospores in NoFly.TM. WP
from Natural Industries, Inc., Houston, Tex., USA or from
Novozymes, U.S.A.), cis-jasmone (U.S. Pat. Nos. 6,890,525;
8,221,736; Plant Bioscience Limited, Norwich, U.K.), laminarin
(e.g. in Vacciplant.RTM. from Laboratoires Goemar, St. Malo, France
or Stahler SA, Switzerland), Lecanicillium longisporum KV42 and
KV71 (e.g. Vertalec.RTM. from Koppert BV, Netherlands), L.
muscarium Ve6 (also called KV01; IMI 19-79, CABI 268317, CBS
102071, ARSEF 5128; e.g. Mycotal.RTM. from Koppert BV,
Netherlands), Lysobacter antibioticus 13-1 (Biological Control 45,
288-296, 2008), L. antibioticus HS124 (Curr. Microbiol. 59(6),
608-615, 2009), L. enzymogenes 3.1T8 (Microbiol. Res. 158, 107-115,
2003; Biological Control 31(2), 145-154, 2004); Melaleuca
alternifolia extract (Mesorhizobium spp. strains known from Soil
Biol. Biochem. 36(8), 1309-1317, 2004; Plant and Soil 348(1-2),
231-243, 2011: M. sp. WSM1271 collected in Sardinia, Italy, from
plant host Biserrula pelecinus, M. sp. WSM 1497 collected in
Mykonos, Greece, from Biserrula pelecinus, Mesorhizobium ciceri
CC1192 collected in Israel from Cicer arietinum nodules (UPM 848,
CECT 5549; Can. J. Microbiol. 48, 279-284, 2002; from Horticultural
Research Station, Gosford, Australia), M. huakuill-IN3015 isolated
from Astralagus sinicus in a rice-growing field of Southern China
(World J. Microbiol. Biotechn. 23(6), 845-851, 2007, ISSN
0959-3993), M. loti CC829 isolated from L. ulginosus nodules in USA
(NZP 2012; commerical inoculant for Lotus pedunculatus and L.
ulginosus in Australia), and M. loti SU343 isolated from host
nodules in USA (commercial inoculant for Lotus corniculatus in
Australia); Metarhizium anisopliae FI-1045 (AGAL V10/0104285; WO
2012/018266; e.g. Biocane.RTM. from BASF Agricultural Specialties
Pty Ltd, Australia), M. anisopliae var. anisopliae F52 also called
275 or V275 (DSM 3884, ATCC 90448; e.g. Met52.RTM. Novozymes
Biologicals BioAg Group, Canada), M. anisopliae ICIPE 69 isolated
from a soil sample obtained from the Democratic Republic of Congo
(DRC) and using the Galleria bait method in 1990 (e.g. Metathripol
from ICIPE, Nairobe, Kenya), M. anisopliae var. acridum IMI 330189
isolated from Ornithacris cavroisi in Niger (NRRL 50758; e.g. Green
Muscle.RTM. from BASF Agricultural Specialities (Pty) Ltd., South
Africa), M. a. var. acridum FI-985 isolated from a spur-throated
locust, Austracris guttulosa (Walker), near Rockhampton,
Queensland, Australia, in 1979 (ARSEF 324; Memoirs of the
Entomological Society of Canada 171, 287-300, 1997; e.g. Green
Guard.RTM. SC from BASF Agricultural Specialties Pty Ltd,
Australia), Metschnikowia fructicola 277 isolated from the surface
of grape berries (cv. Superior) grown in the central part of Israel
(U.S. Pat. No. 6,994,849; NRRL Y-30752; e.g. Shemer.RTM. from
Agrogreen, Israel, now distributed by Bayer CropSciences, Germany),
Microdochium dimerum L13 (CNCM I-3141; e.g. Antibot.RTM. from
Agrauxine, France), Microsphaeropsis ochracea P130A isolated from
apple leaves from an abandoned orchard, St-Joseph-du-Lac, Quebec,
Canada in 1993 (ATCC 74412; Mycologia 94(2), 297-301, 2002),
Muscodor albus QST 20799 also called 620 originally isolated from
the bark of a cinnamon tree in Honduras (NRRL 30547; e.g.
Muscudor.TM. or QRD300 from AgraQuest, USA), Muscodor albus SA-13
(NRRL B-50774; US 2014/0086879 A1; e.g. MBI-601-EP from Marrone
BioInnovations, Inc., USA), Neem oil (e.g. Trilogy.RTM.,
Triact.RTM. 70 EC from Certis LLC, USA), Nomuraea rileyi strains
SA86101, GU87401, SR86151, CG128 and VA9101 (Braz. Arch. Biol.
Technol. 46(1), 13-19, 2003; WO2013/110594), Paecilomyces lilacinus
251 isolated from infected nematode eggs in the Philippines (AGAL
89/030550; WO1991/02051; Crop Protection 27, 352-361, 2008; e.g.
BioAct.RTM./MeloCon.RTM. from Prophyta, Germany), P. lilacinus DSM
15169 (e.g. Nemata.RTM. SC from Live Systems Technology S.A.,
Colombia), P. lilacinus BCP2 (NRRL 50756; Acta agriculturae
Slovenica, 101-2, 263-275, 2013; e.g. PL Gold from BASF
Agricultural Specialities (Pty) Ltd., South Africa), Paenibacillus
alvei NAS6G6 (WO 2014/029697; NRRL B-50755; e.g. BAC-UP from BASF
Agricultural Specialities (Pty) Ltd., South Africa in mixture with
Bacillus pumilus KFP9F), P. polymyxa PKB1 (ATCC 202127; Can. J.
Microbiol. 48(2), 159-169, 2002), Paenibacillus polymyxa Lu16774
(Accession No. DSM 26969), Paenibacillus polymyxa Lu17007
(Accession No. DSM 26970), Paenibacillus sp. Lu17015 (Accession No.
DSM 26971; the Paenibacillus strains Lu16774, Lu 17007 and Lu17015
have been isolated from soil samples from a variety of European
locations including Germany and deposited under the Budapest Treaty
with the Deutsche Sammlung von Mikroorganismen and Zellkulturen
(DSMZ) under the abovementioned Accession numbers on February 201h,
2013 by BASF SE, Germany; the Paenibacillus strains Lu16774, Lu
17007 and Lu17015 are known from WO2016/020371 and the unpublished
applications PCT/EP2017/052532 and PCT/EP2017/052535 from BASF SE,
Germany), Paenibacillus sp. strain NRRL B-50972 and Paenibacillus
sp. strain NRRL B-67129 are known from WO2016/154297, Pantoea
agglomerans E325 (NRRL B-21856; Phytopathol. 101(10), 1234-41,
2011; Trees 26, 227-238, 2012; Bloomtime Biological.TM. from
Northwest Agricultural Products, Inc., USA), Pantoea vagans
(formerly agglomerans) C9-1 originally isolated in 1994 from apple
stem tissue for control of fire blight in apple (J. Bacteriol.
192(24), 6486-6487, 2010; e.g. BlightBan C9-1.RTM. from NuFrams
America Inc., USA), Pasteuria sp. ATCC PTA-9643 (WO 2010/085795),
Pasteuria sp. Ph3 isolated from turfgrass soil samples collected at
the DeBary Golf Course in central Florida (ATCC SD-5832;
WO2012/064527; for control of Hoplolaimus galeatus nematode from
Pasteuria Bioscience, Inc. now Syngenta Crop Protection, LLC, USA),
Pasteuria sp. Pr3 isolated from soil samples collected in the
southeastern United States (ATCC SD-5834; for control of
Rotylenchulus reniformis nematode potentially of species P. ramosa;
Naviva.RTM. ST from Syngenta Crop Protection, LLC, USA), P.
nishizawae (WO2010/80619), P. nishizawae Pn1 (Federal Register
76(22), 5808, Feb. 2, 2011; ATCC SD-5833; e.g. Clariva.TM. PN from
Syngenta Crop Protection, LLC, USA), P. penetrans (U.S. Pat. No.
5,248,500; Del Monte Corp.), P. ramosa (WO 2010/080619), P. thornea
(WO2010/080619), P. usgae BL1 (ATCC SD-5835; J. Nematol. 42(2):
87-90, 2010; ibid. 43(2), 101-109, 2011; e.g. Econem.TM. for
control of Belonolaimus longicaudatus from Pasteuria BioScience now
Syngenta sold by Harell's LLC, Florida, USA for use on turf for
management of Belonolaimus longicaudatus), Penicillium bilaiae
(also called P. bilaii) strains ATCC 18309 (=ATCC 74319), ATCC
20851 and/or ATCC 22348 (=ATCC 74318) originally isolated from soil
in southern Alberta (Fertilizer Res. 39, 97-103, 1994; Can. J.
Plant Sci. 78(1), 91-102, 1998; U.S. Pat. No. 5,026,417, WO
1995/017806; e.g. Jump Start.RTM., Provide.RTM. from Novozymes
Biologicals BioAg Group, Canada), P. bilaiae NRRL 50162 and NRRL
50169 (WO 2010/037228), Phlebiopsis gigantea (e.g. RotStop.RTM.
from Verdera Oy, Finland), Pichia anomala WRL-076 (NRRL Y-30842;
U.S. Pat. No. 8,206,972), potassium bicarbonate (e.g. Amicarb.RTM.
from Stahler SA, Switzerland), potassium silicate (e.g.
Sil-MATRIX.TM. from Certis LLC, USA), Pseudozyma flocculosa PF-A22
UL (e.g. Sporodex.RTM. L from Plant Products Co. Ltd., Canada),
Pseudomonassp. Proradix (DSM 13134; WO 2001/40441, e.g. PRORADIX
from Sourcon Padena GmbH & Co. KG, Hechinger Str. 262, 72072
Tubingen, Germany), P. chlororaphis MA 342 (Microbiology Monographs
18, 21-43, 2011; e.g. Cerall.RTM. or Cedemon.RTM. from BioAgri AB,
Uppsala, Sweden or Intrachem Bio Deutschland GmbH & Co. KG, Bad
Camberg, Germany), P. fluorescens (e.g. in Bio Cure-B from T.
Stanes & Company Limited, India; or in Blight-End from Agri
Naturals, Mumbai, India), P. fluorescens A506 (Phytopathol 97(2),
244-249, 2007; ATCC 31948; e.g. BlightBan.RTM. from NuFarm
Americas, Inc., Morrisville, N.C., USA), P. fluorescens ATCC 13525
of biovar I=biotype A; originally isolated from pre-filter tanks in
England (DSM 50090; registered for use in Canada), P. fluorescens
CHAO (Mol. Plant Microbe Interact. 5(1), 4-13, 1992), P.
fluorescens CL 145A (J. Invertebr. Pathol. 113(1), 104-14, 2013;
e.g. Zequanox.RTM. from Marrone BioInnovations, Davis, Calif.,
USA), P. fluorescens NCIB 12089 (EP 0210734 AI; Victus.RTM. from
Mauri Laboratories, 9 Moorebank Ave., Moorebank, NSW 2170,
Australia), P. fluorescens Pf-5 isolated from root surface of
cotton (ATCC BAA-477), P. putida ATCC 202153 (EMBRAPA 63/88 4 B; WO
2004/0245865), Pythium oligandrum DV 74 (US 2013/0035230; ATCC
38472; e.g. Poyversum.RTM. from Remeslo SSRO, Biopreparaty, Czech
Rep. and from Gowan, USA), Reynoutria sachalinensis extract (EP
0307510 B1; e.g. Regalia.RTM. SC from Marrone BioInnovations,
Davis, Calif., USA or Milsana.RTM. from BioFa AG, Germany),
Rhizobium leguminosarum bv. phaseoli(e.g. RHIZO-STICK from BASF
Corp., USA), R. leguminosarum bv. phaseoli RG-B10 (USDA 9041; from
Int. J. Syst. Bacteriol. 46(1), 240-244, 1996; Int. J. Syst. Evol.
Microbiol. 50, 159-170, 2000; e.g. Nodulator.RTM. Dry Bean in
Africa, Histick NT Dry bean in US, and Nodulator.RTM. Dry Bean in
Canada from BASF Corp., USA, or BASF Agricultural Specialties Ltd.,
Canada), R. I. bv. trifolii CB782 (Nodulaid.RTM. peat for Kenya
white clover from BASF Agricultural Specialties Pty Ltd,
Australia), R. I. bv. trifolii CC275e (Nodulaid.RTM. peat for NZ
white clover from BASF Agricultural Specialties Pty Ltd,
Australia), R. I. bv. trifolii CC283b (ICMP 4073b; Proc. New
Zealand Grassland Assoc. 56, 101-105, 1994; Microbiol. 153,
3184-3195, 2007; Nodulaid.RTM. peat for Caucasian clover from BASF
Agricultural Specialties Pty Ltd, Australia), R. I. bv. trifolii
CC1099 (Inoculating Legumes: A Practical Guide, ed. Grain Research
and Development Corporation, 2012, ISBN 978-1-921779-45-9; e.g.
Nodulaid.RTM. peat for sainfoin from BASF Agricultural Specialties
Pty Ltd, Australia), R. I. bv. trifolii RP113-7 (Appl. Environ.
Microbiol. 44(5), 1096-1101, 1982; e.g. Dormal.RTM. from BASF
Corp., USA), R. I. bv. trifolii TA1 (Appl. Environ. Microbiol.
49(1), 127-131, 1985; e.g. Nodulaid.RTM. peat for white clover from
BASF Agricultural Specialties Pty Ltd, Australia), R. I. bv.
trifolii strain WSM1325 isolated in 1993 from the Greek Island of
Serifos (Stand. Genomic Sci. 2(3), 347-356, 2010; Inoculating
Legumes: A Practical Guide, ed. Grain Research and Development
Corporation, 2012, ISBN 978-1-921779-45-9; Nodulaid.RTM. peat for
sub clover and Nodulator.RTM. granules for sub clover both from
BASF Agricultural Specialties Pty Ltd, Australia, for a broad range
of annual clovers of Mediterranean origin), R. I. bv. trifolii
strain WSM2304 isolated from Trifolium polymorphum in Uruguay in
1998 (Stand. Genomic Sci. 2(1), 66-76, 2010), R. I. bv. viciae
P1NP3Cst being a Streptomycin-resistant mutant of P1NP3C isolated
from pea root nodules in Breteniere, France (also referred to as
1435; New Phytol. 176, 680-690, 2007; ibid. 179(1), 224-235, 2008;
e.g. Nodulator.RTM. PL Peat Granule from BASF Corp., USA; or
Nodulator.RTM. XL PL from BASF Agricultural Specialties Ltd.,
Canada), R. I. bv. viciae RG-P2 also called P2 isolated from pea
root nodules in Saskatchewan, Canada (e. g RhizUP peat for peas and
lentils in Canada from BASF Agricultural Specialties Ltd., Canada),
R. bv. viciae SU303 (e.g. Nodulaid.RTM. Group E from BASF
Agricultural Specialties Pty Ltd, Australia), R. I. bv. viciae
WSM1455 (e.g. Nodulaid.RTM. Group F from BASF Agricultural
Specialties Pty Ltd, Australia), R. tropici CC511 (Agronomy, N.Z.
36, 4-35, 2006; e.g. Nodulaid.RTM. peat for common bean from BASF
Agricultural Specialties Pty Ltd, Australia) R. tropici CIAT 899
isolated in Colombia (SEMIA 4077; Rev. Ci nc. Agron. 44(4)
Fortaleza October/December 2013; e.g. Nitrafix.RTM. FEIJ O peat for
beans from BASF Agricultural Specialties Ltd., Brazil in mixture
with strain SEMIA 4080), R. tropici H12 isolated in Planaltina, DF,
Cerrados, Brazil (SEMIA 4088; Appl. Microbiol. Biotechnol. 93(5),
2035-49, 2012; e.g. Nitrafix.RTM. FEIJ O from BASF Agricultural
Specialties Ltd., Brazil), R. tropici PRF 81 isolated in Parana,
Brazil (SEMIA 4080; Soil Biology & Biochemistry 39, 867-876,
2007; BMC Microbiol. 12, 84, 2012; Nitrafix.RTM. FEIJ O peat for
beans from BASF Agricultural Specialties Ltd., Brazil in mixture
with strain SEMIA 4077), Sinorhizobium meliloti RCR2011 also called
2011 or SU47 (MSDJ0848; Mol. Gen. Genomics 272, 1-17, 2004; e.g.
Dormal.RTM. Alfalfa & Luzerne from BASF Corp., USA;
Nitragin.RTM. Gold from Novozymes Biologicals BioAg Group, Canada),
Sphaerodes mycoparasitica SMCD2220 also called SMCD2220-01 (IDAC
301008-01; WO 2011/022809), Spodoptera littoralis
nucleopolyhedrovirus (SpliNPV) (e.g. in LITTOVIR from Adermatt
Biocontrol, Switzerland), Steinernema carpocapsae (e.g.
Millenium.RTM. from BASF Agricultural Specialities Limited, UK), S.
feltiae (Nemashield.RTM. from BioWorks, Inc., USA; Nemasys.RTM.
from BASF Agricultural Specialities Limited, UK), S. kraussei L137
(Nemasys.RTM. L from BASF Agricultural Specialities Limited, UK),
Streptomyces galbus AQ6047 (NRRL 30232; WO 2012/135763; AgraQuest
now Bayer CropScience LP, USA); S. galbus M1064 (NRRL 50334; WO
2012/135763; AgraQuest now Bayer CropScience LP, USA); S.
griseoviridis K61 (Crop Protection 25, 468-475, 2006; e.g.
Mycostop.RTM. from Verdera Oy, Espoo, Finland), S. lydicus WYEC 108
(U.S. Pat. No. 5,403,584; e.g. Actinovate.RTM. from Natural
Industries, Inc., USA), S. violaceusniger YCED-9 (U.S. Pat. No.
5,968,503; e.g. DT-9.RTM. from Natural Industries, Inc., USA),
Talaromyces flavus V117b isolated from soil (e.g. Protus.RTM. WG
from Prophyta, Germany), Trichoderma asperellum SKT-1 isolated from
the rhizosphere of Japanese lawngrass (FERM P-16510; J. Gen. Plant
Pathol. 71(5), 351-356, 2005; e.g. Eco-Hope.RTM. from Kumiai
Chemical Industry Co., Ltd., Japan), T. asperellum ICC 012 isolated
from a soil in central Italy that was found to suppress plant
disease (IMI 392716; e.g. Tenet WP, Remdier WP or Bioten WP from
Isagro NC, USA, Bio-Tam
.TM. from AgraQuest, USA), T. asperellum TV1 formerly T. viride
(MUCL 43093; e.g. T. viride TV1 from Agribiotec srl, Italy or
Xedavir from Xeda Italia, Italy), T. atroviride LC52 (e.g.
Sentinel.RTM. from Agrimm Technologies Ltd, NZ), T. atroviride CNCM
I-1237 (e.g. Esquive.RTM. WG from Agrauxine S.A., France, e.g.
against pruning wound diseases on vine and plant root pathogens),
T. fertile JM41R (NRRL 50759; e.g. Trichoplus.TM. from BASF
Agricultural Specialities (Pty) Ltd., South Africa), T. gamsii ICC
080 (IMI 392151; e.g. Tenet WP, Remdier WP, Bioten WP from Isagro
NC, USA, Bio-Tam.TM. from AgraQuest, USA), T. harzianum T-22 also
called KRL-AG2 (ATCC 20847; BioControl 57, 687-696, 2012; e.g.
Plantshield.RTM. from BioWorks Inc., USA or SabrEx.TM. from
Advanced Biological Marketing Inc., Van Wert, Ohio, USA), T.
harzianum T-35 and T-315 (ATCC 20691; EP 0133878 B1; e.g. Root
Pro.RTM. from Mycontrol Ltd., Israel), T. harzianum T-39 (CNCM
I-952; EP 0466133 B2; e.g. Trichodex.RTM. or Trichoderma 2000.RTM.
from Mycontrol Ltd., Israel and Makhteshim Ltd., Israel), mixture
of T. harzianum and T. viride (e.g. Trichopel.RTM. from Agrimm
Technologies Ltd, NZ), mixture of T. harzianum ICC012 and T v/ride
ICC080 (e.g. Remdier.RTM. WP from Isagro Ricerca, Italy), T.
polysporum IMI 206039 (ATCC 20476; e.g. Binab.RTM. from BINAB
Bio-Innovation AB, Sweden in mixture with T. atroviride IMI
206040), T. stromaticum (e.g. Tricovab@ from C.E.P.L.A.C., Brazil),
T. virensGI-3 also called G1-3 or GL-3 (CA2471555 A1; ATCC 58678;
e.g. QuickRoots.TM. from TJ Technologies, Watertown, S. Dak., USA
in mixture with B. amyloliquefaciens TJ1000), T. sirens GL-21 also
called G1-21 isolated from a sclerotium of Sclerotinia minor (U.S.
Pat. No. 7,429,477; e.g. Soilguard.RTM. 12G from Certis LLC, USA;
EPA Registration Number: 70051-3 and EPA Establishment Number:
067250-IL-001), T. virens G-41 also called 041, #41X or ABM 127
isolated from soil samples taken from Aphanomyces-suppressive bean
fields in Livingston County, New York (ATCC 20906; U.S. Pat. No.
4,996,157; e.g. Root-shield.RTM. PLUS from BioWorks, Inc., USA), T.
viride (J. Biological Control 23(1), 31-36, 2009; e.g. Trieco.RTM.
from Ecosense Labs. (India) Pvt. Ltd., India; or Bio-Cure.RTM. F
from T. Stanes & Co. Ltd., India), and Ulocladium oudemansii
HRU3 (Agronomy 3, 632-647, 2013; e.g. Botry-Zen.RTM. from Botry-Zen
Ltd, NZ).
[0383] Strains can be obtained from culture collections and
deposition centers (listed by their acronym=strain prefix here:
http://www.wfcc.info/ccinfo/collection/by_acronym/) such as strains
with prefaces AGAL or NMI from: National Measurement Institute,
1/153 Bertie Street, Port Melbourne, Victoria, Australia 3207;
ATCC: American Type Culture Collection, 10801 University Blvd.,
Manassas, Va. 20110-2209, USA; BR: Embrapa Agrobiology
Diazothrophic Microbial Culture Collection, P.O. Box 74.505,
Seropedica, Rio de Janeiro, 23.851-970, Brazil; CABI or IMI: CABI
Europe--International Mycological Institute, Bakeham Lane, Egham,
Surrey, TW20 9TYNRRL, UK; CB: The CB Rhizobium Collection, School
of Environment and Agriculture, University of Western Sydney,
Hawkesbury, Locked Bag 1797, South Penrith Distribution Centre, NSW
1797, Australia; CBS: Centraalbureau voor Schimmelcultures, Fungal
Biodiversity Centre, Uppsalaan 8, PO Box 85167, 3508 AD Utrecht,
Netherlands; CC: Division of Plant Industry, CSIRO, Canberra,
Australia; CNCM: Collection Nationale de Cultures de
Microorganismes, Institute Pasteur, 25 rue du Docteur Roux, F-75724
PARIS Cedex 15; CPAC: Embrapa-Cerrados, CX. Postal
08223,Planaltina, DF, 73301-970, Brazil; DSM: Leibniz-lnstitut
DSMZ-Deutsche Sammlung von Mikroorganismen and Zellkulturen GmbH,
Inhoffenstra e 7 B, 38124 Braunschweig, Germany; IDAC:
International Depositary Authority of Canada Collection, Canada;
ICMP: International Collection of Micro-organisms from Plants,
Landcare Research, Private Bag 92170, Auckland Mail Centre,
Auckland 1142, New Zealand; IITA: IITA, PMB 5320, Ibadan, Nigeria;
INTA: Agriculture Collection Laboratory of the Instituto de
Microbiologia y Zoologia Agricola (IMYZA), Instituto Nacional de
Tecnologi'a Agropecuaria (INTA), Castelar, Argentina; MSDJ:
Laboratoire de Microbiologie des Sols, INRA, Dijon, France; MUCL:
Mycotheque de l'Universite catholique de Louvain, Croix du Sud 2,
box L7.05.06, 1348 Louvain-la-Neuve, Belgium; NCIMB or NICB: The
National Collections of Industrial and Marine Bacteria Ltd., Torry
Research Station, P.O. Box 31, 135 Abbey Road, Aberdeen, AB9 8DG,
Scotland; Nitragin: Nitragin strain collection, The Nitragin
Company, Milwaukee, Wis., USA, NRRL or ARSEF (collection of
entomopathogenic fungi): ARS Culture Collection of the National
Center for Agricultural Utilization Research, Agricultural Research
Service, U.S. Department of Agriculture, 1815 North University
Street, Peoria, Ill. 61604, USA; NZP: Department of Scientific and
Industrial Research Culture Collection, Applied Biochemistry
Division, Palmerston North, New Zealand; PPRI: ARC-Plant Protection
Research Institute, Private Bag X134, Queenswood Pretoria, Gauteng,
0121, South Africa; SEMIA: FEPAGRO-Fundacao Estadual de Pesquisa
Agropecuaria, Rua Goncalves Dias, 570, Bairro Menino Deus, Porto
Alegre/RS, Brazil; SRDI: SARDI, Adelaide, South Australia; USDA:
U.S. Department of Agriculture, Agricultural Research Service,
Soybean and Alfalfa Research Laboratory, BARC-West, 10300 Baltimore
Boulevard, Building 011, Beltsville, Md. 20705, USA (Beltsville
Rhiz. Cult. Catalog: http://pdf.usaid.gov/pdf_docs/PNAAW891.pdf);
and WSM: Murdoch University, Perth, Western Australia. Further
strains may be found at: http://gcm.wfcc.info/;
http://www.landcareresearch.co.nz/resources/collections/icmp.
[0384] Fusaricidins are a group of antibiotics isolated from
Paenibacillus spp., which belong to the class of cyclic
lipodepsipeptides. Among isolated fusaricidin antibiotics,
fusaricidin A has shown the most promising antimicrobial activity
against a variety of clinically relevant fungi and gram-positive
bacteria such a Staphylococcus aureus (MIC value range: 0.78-3.12
.mu.g/ml) (ChemMedChem 7, 871-882, 2012). Fusaricidins A, B, C and
D are also reported to inhibit plant pathogenic fungi such as
Fusarium oxysporum, Aspergillus niger, Aspergillus oryzae, and
Penicillum thomii (J. Antibiotics 49(2), 129-135, 1996; J.
Antibiotics 50(3), 220-228, 1997). Fusaricidins such as Li-F05,
LI-F07 and LI-F08 have been found to have certain antifungal
activity against various plant pathogenic fungi such as Fusarium
moniliforme, F. oxysporum, F. roseum, Giberella fujkuroi,
Helminthosporium sesamum and Penicillium expansum (J. Antibiotics
40(11), 1506-1514, 1987). Fusaricidins also have antibacterial
activity to Gram-positive bacteria including Staphylococcus aureus
(J. Antibiotics 49, 129-135, 1996; J. Antibiotics 50, 220-228,
1997). In addition, fusaricidins have antifungal activity against
Leptosphaeria maculans which causes black root rot of canola (Can.
J. Microbiol. 48, 159-169, 2002). Moreover, fusaricidins A and B
and two related compounds thereof, wherein D-allo-Thr is bound via
its hydroxyl group to an additional alanine using an ester bridge,
produced by certain Paenibacillus strains were found to induce
resistance reactions in cultured parsley cells and to inhibit
growth of Fusarium oxysporum (WO2006/016558; EP1 788 074 A1).
WO2007/086645 describes the fusaricidin synthetase enzyme and its
encoding gene as isolated from Paenibacillus polymyxa strain E681
which enzyme is involved in the synthesis of fusaricidins A, B, C,
D, LI-F03, LI-F05, LI-F07 and LI-F08. The genome of several
Paenibacillus polymyxa strains has been published so far: inter
alia for strain M-1 (NCBI acc. no. NC_017542; J. Bacteriol. 193
(29), 5862-63, 2011; BMC Microbiol. 13, 137, 2013), strain CR1
(GenBank acc. no. CP006941; Genome Announcements 2 (1), 1, 2014)
and strain SC2 (GenBank acc. nos. CP002213 and CP002214; NCBI acc.
no. NC_014622; J. Bacteriol. 193 (1), 311-312, 2011), for further
strains see legend of FIG. 12 herein. The P. polymyxa strain M-1
has been deposited in China General Microbiological Culture
Collection Center (CGMCC) under acc. no. CGMCC 7581. Fusaricidins
isolated from Paenibacillus polymyxa include LI-F03, LI-F04,
LI-F05, LI-F07 and LI-F08 (Kurusu K, Ohba K, Arai T and Fukushima
K., J. Antibiotics, 40: 1506-1514, 1987) and additional
fusaricidins A, B, C and D have been reported (Kajimura Y and
Kaneda M., 1. Antibiotics, 49: 129-135, 1996; Kajimura Y and Kaneda
M., J. Antibiotics, 50:220-228, 1997).
[0385] Fusaricidins 1A and 1B are known from WO2016/020371.
Respective pesticidal mixtures comprising fusaricidins 1 A and/or
1B are known from the yet unpublished applications
PCT/EP2017/052532 and PCT/EP2017/052535.
[0386] In one embodiment, compound II is a fusaricidin selected
from the group consisting of fusaricidin A, fusaricidin B,
fusaricidin C and fusaricidin D.
[0387] In one embodiment, compound II is a fusaricidin selected
from the group consisting of LI-F04c, LI-F04d, LI-F05a, LI F06a, LI
F06b, LI-F08a, LI-F08b, compound 1A and compound 1B.
[0388] In a preferred embodiment, compound II is a fusaricidin
selected from compound 1A and/or compound 1B.
[0389] Paeniserines and paeniprolixines are known from
WO2016/154297.
[0390] In one embodiment, compound II is a paeniserine selected
from the group consisting of paeniserin A1, paeniserin B1,
paeniserin A2, paeniserin A3, paeniserin A4, paeniserin B2,
paeniserin B3, paeniserin B4, paeniserin C1, paeniserin C2,
paeniserin C3, paeniserin C4, paeniserin D1, paeniserin D2,
paeniserin D3, and paeniserin D4.
[0391] In one embodiment, compound II is a paeniprolixine selected
from the group consisting of paeniprolixin A2, paeniprolixin B2,
paeniprolixin C1, paeniprolixin A1, paeniprolixin B1, paeniprolixin
C2, paeniprolixin D1, paeniprolixin D2, paeniprolixin E1,
paeniprolixin E2, paeniprolixin F1, paeniprolixin F2, paeniprolixin
G1, and paeniprolixin G2.
[0392] Jasmonic acid, its salts (jasmonates) or derivatives include
without limitation potassium, sodium, lithium, ammonium,
dimethylammonium, isopropylammonium, diolammonium and
diethtriethanolammonium jasmonate; and also jasmonic acid methyl
ester, jasmonic acid amide, jasmonic acid methylamide, jasmonic
acid-L-amino acid (amide-linked) conjugates (e.g. conjugates with
L-isoleucine, L-valine, L-leucine, or L-phenylalanine),
12-oxo-phytodienoic acid, coronatine, coronalon,
coronafacoyl-L-serine, coronafacoyl-L-threonine, methyl esters of
1-oxo-indanoyl-isoleucine, methyl esters of 1-oxo-indanoyl-leucine,
cis-jasmone, linoleic acid or derivatives thereof, and combinations
of any of the above.
[0393] Humates are humic and fulvic acids extracted from a form of
lignite coal and clay, known as leonardite. Humic acids are organic
acids that occur in humus and other organically derived materials
such as peat and certain soft coal. They have been shown to
increase fertilizer efficiency in phosphate and micro-nutrient
uptake by plants as well as aiding in the development of plant root
systems.
[0394] The present invention furthermore relates to agrochemical
compositions comprising a mixture of at least one compound I and at
least one compound II selected from the group L), in particular at
least one further fungicidal biopesticide selected from the groups
L1) and L2), as described above, and if desired at least one
suitable auxiliary.
[0395] The inventive mixtures comprising as compound II a microbial
pesticide from groups L1), L3) and L5) may be formulated as an
inoculant for a plant. The term "inoculant" means a preparation
that includes an isolated culture of a microbial pesticide and
optionally a carrier, which may include a biologically acceptable
medium.
[0396] According to one embodiment, the microbial pesticides
selected from groups L1), L3) and L5) embrace not only the
isolated, pure cultures of the respective micro-organism as defined
herein, but also its cell-free extract, its suspensions in a whole
broth culture or as a metabolite-containing supernatant or a
purified metabolite obtained from a whole broth culture of the
microorganism or microorganism strain.
[0397] According to a further embodiment, the microbial pesticides
selected from groups L1), L3 and L5) embraces not only the
isolated, pure cultures of the respective micro-organism as defined
herein, but also a cell-free extract thereof or at least one
metabolite thereof, and/or a mutant of the respective
micro-organism having all the identifying characteristics thereof
and also a cell-free extract or at least one metabolite of the
mutant.
[0398] The abovementioned microbial pesticides from groups L1), L3)
and L5) may be isolated or substantially purified. The terms
"isolated" or "substantially purified" refers to microbial
pesticides that have been removed from a natural environment and
have been isolated or separated, and are at least 60% free,
preferably at least 75% free, and more preferably at least 90%
free, even more preferably at least 95% free, and most preferably
at least 100% free from other components with which they were
naturally associated. An "isolated culture" or "substantially
purified culture" refers to a culture of the microbial pesticides
that does not include significant amounts of other materials such
as other materials which normally are found in natural habitat in
which the microbial pesticides grows and/or from which the
microbial pesticides normally may be obtained. An "isolated
culture" may be a culture that does not include any other
biological, microorganism, and/or bacterial species in quantities
sufficient to interfere with the replication of the isolated
culture. Isolated cultures of microbial pesticides may, however, be
combined to prepare a mixed culture of microbial pesticides.
[0399] Herein, microbial pesticides may be supplied in any
physiological state such as active or dormant. Dormant microbial
pesticides may be supplied for example frozen, dried, or
lyophilized or partly desiccated (procedures to produce partly
desiccated organisms are given in WO2008/002371) or in form of
spores.
[0400] Microbial pesticides selected from groups L1), L3) and L5)
used as organism in an active state can be delivered in a growth
medium without any additional additives or materials or in
combination with suitable nutrient mixtures.
[0401] The mixtures and compositions according to the invention can
also be present together with further pesticides, e.g. with
herbicides, insecticides, growth regulators, fungicides; or else
with fertilizers, as pre-mix or, if appropriate, not until
immediately prior to use (tank mix).
[0402] In one embodiment, the mixture according to the invention
comprises as active components one active compound I (nitrification
inhibitor), or an agriculturally useful salt thereof, and one
active compound II (biopesticide) selected from groups L1) to L6)
and one active compound III selected from group of herbicides,
insecticides, growth regulators, fungicides, urease inhibitors,
nitrification inhibitors, and denitrification inhibitors.
[0403] Mixing a composition comprising at least one compound I and
at least one compound II with further fungicides results in many
cases in an improvement of the nitrification inhibition effect
and/or an improvement of the health of a plant and/or an
improvement of the plant growth regulation. Furthermore, in many
cases, synergistic effects are obtained.
[0404] Mixing a composition comprising at least one compound I and
at least one compound II with further fungicides results in many
cases in an expansion of the fungicidal spectrum of activity or in
a prevention of fungicide resistance development. Furthermore, in
many cases, synergistic effects are obtained.
[0405] Mixing a composition comprising at least one compound I and
at least one compound II with further insecticides results in many
cases in an expansion of the insecticidal spectrum of activity or
in a prevention of insecticide resistance development. Furthermore,
in many cases, synergistic effects are obtained.
[0406] The mixtures and compositions according to the invention are
suitable as nitrification inhibitors, improvers for the plant
yield, or improvers for the plant health.
[0407] The mixtures and compositions according to the invention are
also suitable as fungicides. They are distinguished by an
outstanding effectiveness against a broad spectrum of
phytopathogenic fungi, including soil-borne fungi, which derive
especially from the classes of the Plasmodiophoromycetes,
Peronosporomycetes (syn. Oomycetes), Chytridiomycetes, Zygomycetes,
Ascomycetes, Basidiomycetes and Deuteromycetes (syn. Fungi
imperfecti). Some are systemically effective and they can be used
in crop protection as foliar fungicides, fungicides for seed
dressing and soil fungicides. Moreover, they are suitable for
controlling harmful fungi, which inter alia occur in wood or roots
of plants.
[0408] The mixtures and compositions according to the invention are
particularly important in the control of a multitude of
phytopathogenic fungi on various cultivated plants, such as
cereals, e.g. wheat, rye, barley, triticale, oats or rice; beet,
e.g. sugar beet or fodder beet; fruits, such as pomes, stone fruits
or soft fruits, e.g. apples, pears, plums, peaches, almonds,
cherries, strawberries, raspberries, blackberries or gooseberries;
leguminous plants, such as lentils, peas, alfalfa or soybeans; oil
plants, such as rape, mustard, olives, sunflowers, coconut, cocoa
beans, castor oil plants, oil palms, ground nuts or soybeans;
cucurbits, such as squashes, cucumber or melons; fiber plants, such
as cotton, flax, hemp or jute; citrus fruit, such as oranges,
lemons, grapefruits or mandarins; vegetables, such as spinach,
lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes,
cucurbits or paprika; lauraceous plants, such as avocados, cinnamon
or camphor; energy and raw material plants, such as corn, soybean,
rape, sugar cane or oil palm; corn; tobacco; nuts; coffee; tea;
bananas; vines (table grapes and grape juice grape vines); hop;
turf; natural rubber plants or ornamental and forestry plants, such
as flowers, shrubs, broad-leaved trees or evergreens, e.g.
conifers; and on the plant propagation material, such as seeds, and
the crop material of these plants.
[0409] Preferably the inventive mixtures and compositions are used
for controlling a multitude of fungi on field crops, such as
potatoes sugar beets, tobacco, wheat, rye, barley, oats, rice,
corn, cotton, soybeans, rape, legumes, sunflowers, coffee or sugar
cane; fruits; vines; ornamentals; or vegetables, such as cucumbers,
tomatoes, beans or squashes.
[0410] The term "plant propagation material" is to be understood to
denote all the generative parts of the plant such as seeds and
vegetative plant material such as cuttings and tubers (e.g.
potatoes), which can be used for the multiplication of the plant.
This includes seeds, roots, fruits, tubers, bulbs, rhizomes,
shoots, sprouts and other parts of plants, including seedlings and
young plants, which are to be transplanted after germination or
after emergence from soil.
[0411] These young plants may also be protected before
transplantation by a total or partial treatment by immersion or
pouring.
[0412] Preferably, treatment of plant propagation materials with
the inventive mixtures and compositions thereof, respectively, is
used for controlling a multitude of fungi on cereals, such as
wheat, rye, barley and oats; rice, corn, cotton and soybeans.
[0413] The term "cultivated plants" is to be understood as
including plants which have been modified by breeding, mutagenesis
or genetic engineering including but not limiting to agricultural
biotech products on the market or in development (cf.
http://cera-gmc.org/, see GM crop database therein). Genetically
modified plants are plants, which genetic material has been so
modified by the use of recombinant DNA techniques that under
natural circumstances cannot readily be obtained by cross breeding,
mutations or natural recombination. Typically, one or more genes
have been integrated into the genetic material of a genetically
modified plant in order to improve certain properties of the plant.
Such genetic modifications also include but are not limited to
targeted post-transitional modification of protein(s), oligo- or
polypeptides e.g. by glycosylation or polymer additions such as
prenylated, acetylated or farnesylated moieties or PEG
moieties.
[0414] Plants that have been modified by breeding, mutagenesis or
genetic engineering, e.g. have been rendered tolerant to
applications of specific classes of herbicides, such as
hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors; acetolactate
synthase (ALS) inhibitors, such as sulfonyl ureas (see e.g. U.S.
Pat. No. 6,222,100, WO 01/82685, WO 00/26390, WO 97/41218, WO
98/02526, WO 98/02527, WO 04/106529, WO 05/20673, WO 03/14357, WO
03/13225, WO 03/14356, WO 04/16073) or imidazolinones (see e.g.
U.S. Pat. No. 6,222,100, WO 01/82685, WO 00/026390, WO 97/41218, WO
98/002526, WO 98/02527, WO 04/106529, WO 05/20673, WO 03/014357, WO
03/13225, WO 03/14356, WO 04/16073);
enolpyruvylshikimate-3-phosphate synthase (EPSPS) inhibitors, such
as glyphosate (see e.g. WO 92/00377); glutamine synthetase (GS)
inhibitors, such as glufosinate (see e.g. EP-A 242 236, EP-A 242
246) or oxynil herbicides (see e.g. U.S. Pat. No. 5,559,024) as a
result of conventional methods of breeding or genetic engineering.
Several cultivated plants have been rendered tolerant to herbicides
by conventional methods of breeding (mutagenesis), e.g.
Clearfield.RTM. summer rape (Canola, BASF SE, Germany) being
tolerant to imidazolinones, e.g. imazamox. Genetic engineering
methods have been used to render cultivated plants such as soybean,
cotton, corn, beets and rape, tolerant to herbicides such as
glyphosate and glufosinate, some of which are commercially
available under the trade names RoundupReady.RTM.
(glyphosate-tolerant, Monsanto, U.S.A.) and LibertyLink.RTM.
(glufosinate-tolerant, Bayer CropScience, Germany).
[0415] Furthermore, plants are also covered that are by the use of
recombinant DNA techniques capable to synthesize one or more
insecticidal proteins, especially those known from the bacterial
genus Bacillus, particularly from Bacillus thuringiensis, such as
6-endotoxins, e.g. CryIA(b), CryIA(c), CryIF, CryIF(a2), CryIIA(b),
CryIIIA, CryIIIB(b1) or Cry9c; vegetative insecticidal proteins
(VIP), e.g. VIP1, VIP2, VIP3 or VIP3A; insecticidal proteins of
bacteria colonizing nematodes, e.g. Photorhabdus spp. or
Xenorhabdus spp.; toxins produced by animals, such as scorpion
toxins, arachnid toxins, wasp toxins, or other insect-specific
neurotoxins; toxins produced by fungi, such Streptomycetes toxins,
plant lectins, such as pea or barley lectins; agglutinins;
proteinase inhibitors, such as trypsin inhibitors, serine protease
inhibitors, patatin, cystatin or papain inhibitors;
ribosome-inactivating proteins (RIP), such as ricin, maize-RIP,
abrin, luffin, saporin or bryodin; steroid metabolism enzymes, such
as 3-hydroxysteroid oxidase, ecdysteroid-IDP-glycosyl-transferase,
cholesterol oxidases, ecdysone inhibitors or HMG-CoA-reductase; ion
channel blockers, such as blockers of sodium or calcium channels;
juvenile hormone esterase; diuretic hormone receptors (helicokinin
receptors); stilben synthase, bibenzyl synthase, chitinases or
glucanases. In the context of the present invention these
insecticidal proteins or toxins are to be understood expressly also
as pre-toxins, hybrid proteins, truncated or otherwise modified
proteins. Hybrid proteins are characterized by a new combination of
protein domains, (see, e.g. WO02/015701). Further examples of such
toxins or genetically modified plants capable of synthesizing such
toxins are disclosed, e.g., in EP-A374753, WO93/007278, WO95/34656,
EP-A427529, EP-A451 878, WO03/18810 and WO03/52073. The methods for
producing such genetically modified plants are generally known to
the person skilled in the art and are described, e.g. in the
publications mentioned above. These insecticidal proteins contained
in the genetically modified plants impart to the plants producing
these proteins tolerance to harmful pests from all taxonomic groups
of athropods, especially to beetles (Coeloptera), two-winged
insects (Diptera), and moths (Lepidoptera) and to nematodes
(Nematoda). Genetically modified plants capable to synthesize one
or more insecticidal proteins are, e.g., described in the
publications mentioned above, and some of which are commercially
available such as YieldGard.RTM. (corn cultivars producing the
CryIAb toxin), YieldGard.RTM. Plus (corn cultivars producing CryIAb
and Cry3Bb1 toxins), Starlink.RTM. (corn cultivars producing the
Cry9c toxin), Herculex.RTM. RW (corn cultivars producing Cry34Ab1,
Cry35Ab1 and the enzyme Phosphinothricin-N-Acetyltransferase
[PAT]); NuCOTN.RTM. 33B (cotton cultivars producing the CryIAc
toxin), Bollgard.RTM. I (cotton cultivars producing the CryIAc
toxin), Bollgard.RTM. II (cotton cultivars producing CryIAc and
Cry2Ab2 toxins); VIPCOT.RTM. (cotton cultivars producing a
VIP-toxin); NewLeaf.RTM. (potato cultivars producing the Cry3A
toxin); Bt-Xtra.RTM., NatureGard.RTM., KnockOut.RTM.,
BiteGard.RTM., Protecta.RTM., Bt11 (e.g. Agrisure.RTM. CB) and
Bt176 from Syngenta Seeds SAS, France, (corn cultivars producing
the Cry1Ab toxin and PAT enyzme), MIR604 from Syngenta Seeds SAS,
France (corn cultivars producing a modified version of the Cry3A
toxin, c.f. WO 03/018810), MON 863 from Monsanto Europe S.A.,
Belgium (corn cultivars producing the Cry3Bb1 toxin), IPC 531 from
Monsanto Europe S.A., Belgium (cotton cultivars producing a
modified version of the CryIAc toxin) and 1507 from Pioneer
Overseas Corporation, Belgium (corn cultivars producing the Cry1F
toxin and PAT enzyme).
[0416] Furthermore, plants are also covered that are by the use of
recombinant DNA techniques capable to synthesize one or more
proteins to increase the resistance or tolerance of those plants to
bacterial, viral or fungal pathogens. Examples of such proteins are
the so-called "pathogenesis-related proteins" (PR proteins, see,
e.g. EP-A 392 225), plant disease resistance genes (e.g. potato
cultivars, which express resistance genes acting against
Phytophthora infestans derived from the Mexican wild potato Solanum
bulbocastanum) or T4-lysozym (e.g. potato cultivars capable of
synthesizing these proteins with increased resistance against
bacteria such as Erwinia amylvora). The methods for producing such
genetically modified plants are generally known to the person
skilled in the art and are described, e.g. in the publications
mentioned above.
[0417] Furthermore, plants are also covered that are by the use of
recombinant DNA techniques capable to synthesize one or more
proteins to increase the productivity (e.g. bio mass production,
grain yield, starch content, oil content or protein content),
tolerance to drought, salinity or other growth-limiting
environmental factors or tolerance to pests and fungal, bacterial
or viral pathogens of those plants.
[0418] Furthermore, plants are also covered that contain by the use
of recombinant DNA techniques a modified amount of substances of
content or new substances of content, specifically to improve human
or animal nutrition, e.g. oil crops that produce health-promoting
long-chain omega-3 fatty acids or unsaturated omega-9 fatty acids
(e.g. Nexera.RTM. rape, DOW Agro Sciences, Canada).
[0419] Furthermore, plants are also covered that contain by the use
of recombinant DNA techniques a modified amount of substances of
content or new substances of content, specifically to improve raw
material production, e.g. potatoes that produce increased amounts
of amylopectin (e.g. Amflora.RTM. potato, BASF SE, Germany).
[0420] The inventive mixtures and compositions are particularly
suitable for controlling the following plant diseases:
Albugo spp. (white rust) on ornamentals, vegetables (e.g. A.
candida) and sunflowers (e.g. A. tragopogonis); Alternaria spp.
(Alternaria leaf spot) on vegetables, rape (A. brassicola or
brassicae), sugar beets (A. lentils), fruits, rice, soybeans,
potatoes (e.g. A. solani or A. alternata), tomatoes (e.g. A. solani
or A. alternata) and wheat; Aphanomyces spp. on sugar beets and
vegetables; Ascochyta spp. on cereals and vegetables, e.g. A.
tritici (anthracnose) on wheat and A. hordei on barley; Bipolaris
and Drechslera spp. (teleomorph: Cochliobolus spp.) on corn (e.g.
D. maydis), cereals (e.g. B. sorokiniana: spot blotch), rice (e.g.
B. oryzae) and turfs; Blumeria (formerly Erysiphe) graminis
(powdery mildew) on cereals (e.g. on wheat or barley); Botrytis
cinerea (teleomorph: Botryotinia fuckeliana: grey mold) on fruits
and berries (e.g. strawberries), vegetables (e.g. lettuce, carrots,
celery and cabbages), rape, flowers, vines, forestry plants and
wheat; Bremia lactucae (downy mildew) on lettuce; Ceratocystis
(syn. Ophiostoma) spp. (rot or wilt) on broad-leaved trees and
evergreens, e.g. C. ulmi (Dutch elm disease) on elms; Cercospora
spp. (Cercospora leaf spots) on corn, rice, sugar beets (e.g. C.
beticola), sugar cane, vegetables, coffee, soybeans (e.g. C. sojina
or C. kikuchii) and rice; Cladosporium spp. on tomatoes (e.g. C.
fulvum: leaf mold) and cereals, e.g. C. herbarum (black ear) on
wheat; Claviceps purpurea (ergot) on cereals; Cochliobolus
(anamorph: Helminthosporium of Bipolaris) spp. (leaf spots) on corn
(C. carbonum), cereals (e.g. C. sativus, anamorph: B. sorokiniana)
and rice (e.g. C. mivabeanus, anamorph: H. oryzae); Colletotrichum
(teleomorph: Glomerella) spp. (anthracnose) on cotton (e.g. C.
gossypii), corn (e.g. C. graminicola), soft fruits, potatoes (e.g.
C. coccodes: black dot), beans (e.g. C. lindemuthianum) and
soybeans (e.g. C. truncatum or C. gloeosporioides); Corticium spp.,
e.g. C. sasakii (sheath blight) on rice; Corynespora cassiicola
(leaf spots) on soybeans and ornamentals; Cycloconium spp., e.g. C.
oleaginum on olive trees; Cylindrocarpon spp. (e.g. fruit tree
canker or young vine decline, teleomorph: Nectria or Neonectria
spp.) on fruit trees, vines (e.g. C. liriodendri, teleomorph:
Neonectria liriodendri: Black Foot Disease) and ornamentals;
Dematophora (teleomorph: Rosellinia) necatrix (root and stem rot)
on soybeans; Diaporthe spp., e.g. D. phaseolorum (damping off) on
soybeans; Drechslera (syn. Helminthosporium, teleomorph:
Pyrenophora) spp. on corn, cereals, such as barley (e.g. D. teres,
net blotch) and wheat (e.g. D. tritici-repentis: tan spot), rice
and turf; Esca (dieback, apoplexy) on vines, caused by Formitiporia
(syn. Phellinus) punctata, F. mediterranea, Phaeomoniella
chlamydospora (earlier Phaeoacremonium chlamydosporum),
Phaeoacremonium aleophilum and/or Botryosphaeria obtusa, Elsinoe
spp. on pome fruits (E. pyri), soft fruits (E. veneta: anthracnose)
and vines (E. ampelina: anthracnose); Entyloma oryzae (leaf smut)
on rice; Epicoccum spp. (black mold) on wheat; Erysiphe spp.
(powdery mildew) on sugar beets (E. betae), vegetables (e.g. E.
pisi), such as cucurbits (e.g. E. cichoracearum), cabbages, rape
(e.g. E. cruciferarum); Eutypa lata (Eutypa canker or dieback,
anamorph: Cytosporina lata, syn. Libertella blepharis) on fruit
trees, vines and ornamental woods; Exserohilum (syn.
Helminthosporium) spp. on corn (e.g. E. turcicum); Fusarium
(teleomorph: Gibberella) spp. (wilt, root or stem rot) on various
plants, such as F. graminearum or F. culmorum (root rot, scab or
head blight) on cereals (e.g. wheat or barley), F. oxysporum on
tomatoes, F. solani on soybeans and F. verticillioides on corn;
Gaeumannomyces graminis (take-all) on cereals (e.g. wheat or
barley) and corn; Gibberella spp. on cereals (e.g. G. zeae) and
rice (e.g. G. fujikuror: Bakanae disease); Glomerella cingulata on
vines, pome fruits and other plants and G. gossypii on cotton;
Grainstaining complex on rice; Guignardia bidwellii (black rot) on
vines; Gymnosporangium spp. on rosaceous plants and junipers, e.g.
G. sabinae (rust) on pears; Helminthosporium spp. (syn. Drechslera,
teleomorph: Cochliobolus) on corn, cereals and rice; Hemileia spp.,
e.g. H. vastatrix (coffee leaf rust) on coffee; Isariopsis
clavispora (syn. Cladosporium vitis) on vines; Macrophomina
phaseolina (syn. phaseoli) (root and stem rot) on soybeans and
cotton; Microdochium (syn. Fusarium) nivale (pink snow mold) on
cereals (e.g. wheat or barley); Microsphaera diffusa (powdery
mildew) on soybeans; Monolinia spp., e.g. M. laxa, M. fructicola
and M. fructigena (bloom and twig blight, brown rot) on stone
fruits and other rosaceous plants; Mycosphaerella spp. on cereals,
bananas, soft fruits and ground nuts, such as e.g. M graminicola
(anamorph: Septoria tritici, Septoria blotch) on wheat; Peronospora
spp. (downy mildew) on cabbage (e.g. P. brassicae), rape (e.g. P.
parasitica), onions (e.g. P. destructor), tobacco (P. tabacina) and
soybeans (e.g. P. manshurica); Phakopsora pachyrhizi and P.
meibomiae (soybean rust) on soybeans; Phialophora spp. e.g. on
vines (e.g. P. tracheiphila and P. tetraspora) and soybeans (e.g.
P. gregata: stem rot); Phoma lingam (root and stem rot) on rape and
cabbage and P. betae (root rot, leaf spot and damping-off) on sugar
beets; Phomopsis spp. on sunflowers, vines (e.g. P. viticola: can
and leaf spot) and soybeans (e.g. stem rot: P. phaseoli,
teleomorph: Diaporthe phaseolorum); Physoderma maydis (brown spots)
on corn; Phytophthora spp. (wilt, root, leaf, fruit and stem root)
on various plants, such as paprika and cucurbits (e.g. P. capsid),
soybeans (e.g. P. megasperma, syn. P. sojae), potatoes and tomatoes
(e.g. P. infestans late blight) and broad-leaved trees (e.g. P.
ramorum: sudden oak death); Plasmodiophora brassicae (club root) on
cabbage, rape, radish and other plants; Plasmopara spp., e.g. P.
viticola (grapevine downy mildew) on vines and P. halstedii on
sunflowers; Podosphaera spp. (powdery mildew) on rosaceous plants,
hop, pome and soft fruits, e.g. P. leucotricha on apples; Polymyxa
spp., e.g. on cereals, such as barley and wheat (P. graminis) and
sugar beets (P. betae) and thereby transmitted viral diseases;
Pseudocercosporella herpotrichoides (eyespot, teleomorph: Tapesia
yallundae) on cereals, e.g. wheat or barley; Pseudoperonospora
(downy mildew) on various plants, e.g. P. cubensis on cucurbits or
P. humili on hop; Pseudopezicula tracheiphila (red fire disease or
`rotbrenner`, anamorph: Phialophora) on vines; Puccinia spp.
(rusts) on various plants, e.g. P. triticina (brown or leaf rust),
P. striiformis (stripe or yellow rust), P. hordei (dwarf rust), P.
graminis (stem or black rust) or P. recondita (brown or leaf rust)
on cereals, such as e.g. wheat, barley or rye, and asparagus (e.g.
P. asparagi); Pyrenophora (anamorph: Drechslera) tritici-repentis
(tan spot) on wheat or P. teres (net blotch) on barley; Pyricularia
spp., e.g. P. oryzae (teleomorph: Magnaporthe grisea, rice blast)
on rice and P. grisea on turf and cereals; Pythium spp.
(damping-off) on turf, rice, corn, wheat, cotton, rape, sunflowers,
soybeans, sugar beets, vegetables and various other plants (e.g. P.
ultimum or P. aphanidermatum); Ramularia spp., e.g. R.
collo-cygni(Ramularia leaf spots, Physiological leaf spots) on
barley and R. beticola on sugar beets; Rhizoctonia spp. on cotton,
rice, potatoes, turf, corn, rape, potatoes, sugar beets, vegetables
and various other plants, e.g. R. solani (root and stem rot) on
soybeans, R. solani (sheath blight) on rice or R. cerealis
(Rhizoctonia spring blight) on wheat or barley; Rhizopus stolonifer
(black mold, soft rot) on strawberries, carrots, cabbage, vines and
tomatoes; Rhynchosporium secalis (scald) on barley, rye and
triticale; Sarocladium oryzae and S. attenuatum (sheath rot) on
rice; Sclerotinia spp. (stem rot or white mold) on vegetables and
field crops, such as rape, sunflowers (e.g. S. sclerotiorum) and
soybeans (e.g. S. rolfsi or S. sclerotiorum); Septoria spp. on
various plants, e.g. S. glycines (brown spot) on soybeans, S.
tritici (Septoria blotch) on wheat and S. (syn. Stagonospora)
nodorum (Stagonospora blotch) on cereals; Uncinula (syn. Erysiphe)
necator (powdery mildew, anamorph: Oidium tuckeri) on vines;
Setospaeria spp. (leaf blight) on corn (e.g. S. turcicum, syn.
Helminthosporium turcicum) and turf; Sphacelotheca spp. (smut) on
corn, (e.g. S. reiliana: head smut), sorghum and sugar cane;
Sphaerotheca fuliginea (powdery mildew) on cucurbits; Spongospora
subterranea (powdery scab) on potatoes and thereby transmitted
viral diseases; Stagonospora spp. on cereals, e.g. S. nodorum
(Stagonospora blotch, teleomorph: Leptosphaeria [syn.
Phaeosphaeria] nodorum) on wheat; Synchytrium endobioticum on
potatoes (potato wart disease); Taphrina spp., e.g. T. deformans
(leaf curl disease) on peaches and T. pruni (plum pocket) on plums;
Thielaviopsis spp. (black root rot) on tobacco, pome fruits,
vegetables, soybeans and cotton, e.g. T. basicola (syn. Chalara
elegans); Tilletia spp. (common bunt or stinking smut) on cereals,
such as e.g. T. tritici (syn. T. caries, wheat bunt) and T.
controversa (dwarf bunt) on wheat; Typhula incarnata (grey snow
mold) on barley or wheat; Urocystis spp., e.g. U. occulta (stem
smut) on rye; Uromyces spp. (rust) on vegetables, such as beans
(e.g. U. appendiculatus, syn. U. phaseoli) and sugar beets (e.g. U.
betae); Ustilago spp. (loose smut) on cereals (e.g. U. nuda and U.
avaenae), corn (e.g. U. maydis: corn smut) and sugar cane; Venturia
spp. (scab) on apples (e.g. V. inaequalis) and pears; and
Verticillium spp. (wilt) on various plants, such as fruits and
ornamentals, vines, soft fruits, vegetables and field crops, e.g.
V. dahliae on strawberries, rape, potatoes and tomatoes.
[0421] In a preferred embodiment the compounds I, mixtures
comprising them and agrochemical compositions thereof,
respectively, are particularly suitable for controlling the
following plant diseases: Puccinia spp. (rusts) on various plants,
for example, but not limited to P. triticina (brown or leaf rust),
P. striiformis (stripe or yellow rust), P. hordei (dwarf rust), P.
graminis (stem or black rust) or P. recondita (brown or leaf rust)
on cereals, such as e.g. wheat, barley or rye and Phakopsoraceae
spp. on various plants, in particular Phakopsora pachyrhizi and P.
meibomiae (soybean rust) on soybeans.
[0422] In particular, the mixtures and compositions of the present
invention are effective against plant pathogens in specialty crops
such as vine, fruits, hop, vegetables and tobacco.
[0423] Bacteria pathogenic for plants are responsible for
devastating losses in agriculture. The use of antibiotics to
control such infections is restricted in many countries due to
worries over the evolution and transmission of antibiotic
resistance.
[0424] The mixtures and compositions according to the invention are
also suitable as bactericides. They are distinguished by an
outstanding effectiveness against a broad spectrum of
phytopathogenic bacteria, including soil-borne bacteria, which
derive especially from the genera of Agrobacterium, Clavibacter,
Corynebacterium, Erwinia, Leifsonia, Pectobacterium, Pseudomonas,
Ralstonia, Xanthomonas (e.g. Xanthomonas oryzae causing bacterial
blight on rice) and Xylella; preferably Erwinia; even more
preferably Erwinia amylovora causing fire blight on apples, pears
and other member of the family Rosaceae.
[0425] The mixtures according to the present invention and
compositions thereof, respectively, are also suitable for
controlling harmful fungi in the protection of stored products or
harvest and in the protection of materials. The term "protection of
materials" is to be understood to denote the protection of
technical and non-living materials, such as adhesives, glues, wood,
paper and paperboard, textiles, leather, paint dispersions,
plastics, coiling lubricants, fiber or fabrics, against the
infestation and destruction by harmful microorganisms, such as
fungi and bacteria. As to the protection of wood and other
materials, the particular attention is paid to the following
harmful fungi: Ascomycetes such as Ophiostoma spp., Ceratocystis
spp., Aureobasidium pullulans, Sclerophoma spp., Chaetomium spp.,
Humicola spp., Petriella spp., Trichurus spp.; Basidiomycetes such
as Coniophora spp., Coriolus spp., Gloeophyllum spp., Lentinus
spp., Pleurotus spp., Poria spp., Serpula spp. and Tyromyces spp.,
Deuteromycetes such as Aspergillus spp., Cladosporium spp.,
Penicillium spp., Trichorma spp., Alternaria spp., Paecilomyces
spp. and Zygomycetes such as Mucor spp., and in addition in the
protection of stored products and harvest the following yeast fungi
are worthy of note: Candida spp. and Saccharomyces cerevisae.
[0426] The method of treatment according to the invention can also
be used in the field of protecting stored products or harvest
against attack of fungi and microorganisms. According to the
present invention, the term "stored products" is understood to
denote natural substances of plant or animal origin and their
processed forms, which have been taken from the natural life cycle
and for which long-term protection is desired. Stored products of
crop plant origin, such as plants or parts thereof, for example
stalks, leafs, tubers, seeds, fruits or grains, can be protected in
the freshly harvested state or in processed form, such as
pre-dried, moistened, comminuted, ground, pressed or roasted, which
process is also known as post-harvest treatment. Also falling under
the definition of stored products is timber, whether in the form of
crude timber, such as construction timber, electricity pylons and
barriers, or in the form of finished articles, such as furniture or
objects made from wood. Stored products of animal origin are hides,
leather, furs, hairs and the like. The combinations according the
present invention can prevent disadvantageous effects such as
decay, discoloration or mold. Preferably "stored products" is
understood to denote natural substances of plant origin and their
processed forms, more preferably fruits and their processed forms,
such as pomes, stone fruits, soft fruits and citrus fruits and
their processed forms.
[0427] The mixtures and compositions according to the invention are
particularly important in the control of a multitude of
phytopathogenic insects or other pests (e.g. lepidopterans,
beetles, dipterans, thrips, heteropterans, hemiptera, homoptera,
termites, orthopterans, arachnids, and nematodes) on various
cultivated plants, such as cereals, e.g. wheat, rye, barley,
triticale, oats or rice; beet, e.g. sugar beet or fodder beet;
fruits, such as pomes, stone fruits or soft fruits, e.g. apples,
pears, plums, peaches, almonds, cherries, strawberries,
raspberries, blackberries or gooseberries; leguminous plants, such
as lentils, peas, alfalfa or soybeans; oil plants, such as rape,
mustard, olives, sunflowers, coconut, cocoa beans, castor oil
plants, oil palms, ground nuts or soybeans; cucurbits, such as
squashes, cucumber or melons; fiber plants, such as cotton, flax,
hemp or jute; citrus fruit, such as oranges, lemons, grapefruits or
mandarins; vegetables, such as spinach, lettuce, asparagus,
cabbages, carrots, onions, tomatoes, potatoes, cucurbits or
paprika; lauraceous plants, such as avocados, cinnamon or camphor;
energy and raw material plants, such as corn, soybean, rape, sugar
cane or oil palm; corn; tobacco; nuts; coffee; tea; bananas; vines
(table grapes and grape juice grape vines); hop; turf; natural
rubber plants or ornamental and forestry plants, such as flowers,
shrubs, broad-leaved trees or evergreens, e.g. conifers; and on the
plant propagation material, such as seeds, and the crop material of
these plants.
[0428] Preferably the inventive mixtures and compositions are used
for controlling a multitude of pests on field crops, such as
potatoes sugar beets, tobacco, wheat, rye, barley, oats, rice,
corn, cotton, soybeans, rape, legumes, sunflowers, coffee or sugar
cane; fruits; vines; ornamentals; or vegetables, such as cucumbers,
tomatoes, beans or squashes.
[0429] The inventive mixtures and the compositions thereof,
respectively, are particularly suitable for controlling the
following harmful insects from the order of the
lepidopterans (Lepidoptera), for example Agrotis ypsilon, Agrotis
segetum, Alabama argillacea, Anticarsia gemmatalis, Argyresthia
conjugella, Autographa gamma, Bupalus piniarius, Cacoecia murinana,
Capua reticulana, Cheimatobla brumata, Choristoneura fumiferana,
Choristoneura occidentalis, Cirphis unipuncta, Cydia pomonella,
Dendrolimus pini, Diaphania Diatraea grandiosella, Earias insulana,
Elasmopalpus lignosellus, Eupoecilia ambiguella, Evetria bouliana,
Feltia subterranea, Galleria mellonella, Grapholitha funebrana,
Grapholitha molesta, Heliothis armigera, Hellothis virescens,
Heliothis zea, Hellula undalis, Hibernia defoliafia, Hyphantria
cunea, Hyponomeuta malinellus, Keiferia lycopersicella, Lambdina
fiscellaria, Laphygma exigua, Leucoptera coffeella, Leucoptera
scitella, Lithocolletis blancardella, Lobesia botrana, Loxostege
sticticalis, Lymantria dispar, Lymantfia monacha, Lyonetia
clerkella, Malacosoma neustria, Mamestra brassicae, Orgyia
pseudotsugata, Ostrinia nubilalis, Panolis flammea, Pectinophora
gossypiella, Peridroma saucia, Phalera bucephala, Phthorimaea
operculella, Phyllocnistis citrella, Piers brassicae, Plathypena
scabra, Plutella xylostella, Pseudoplusia includens, Rhyacionia
frustrana, Scrobipalpula absoluta, Sitotroga cerealella,
Sparganothis pilleriana, Spodoptera frugiperda, Spodoptera
littoralis, Spodoptera litura, Thaumatopoea pityocampa, Tortrix
viridana, Trichoplusia ni and Zeiraphera canadensis, beetles
(Coleoptera), for example Agrilus sinuatus, Agfiotes lineatus,
Agriotes obscurus, Amphimallus solstitialis, Anisandrus dispar,
Anthonomus grandis, Anthonomus pomorum, Atomaria liearis,
Blastophagus piniperda, Blitophaga undata, Bruchus rufimanus,
Bruchus pisorum, Bruchus lentis, Byctiscus betulae, Cassida
nebulosa, Cerotoma trifurcata, Ceuthorrhynchus assimilis,
Ceuthorrhynchus napi, Chaetocnema tibialis, Conoderus vespertinus,
Crioceris asparagi, Diabrotica longicornis, Diabrotica speciosa,
Diabrotica 12-punctata, Diabrotica virgifera, Dlloboderus abderus,
Epilachna varivestis, Epitrix hirtipennis, Eutinobothrus
brasiliensis, Hylobius abietis, Hypera brunneipennis, Hypera
postica, Ips typographus, Lema bilineata, Lema melanopus,
Leptinotarsa decemlineata, Limonius califomicus, Lissorhoptrus
oryzophilus, Melanotus communis, Meligethes aeneus, Melolontha
hippocastani, Melolontha melolontha, Oulema oryzae, Ortiorrhynchus
sulcatus, Oryazophagus oryzae, Otiorrhynchus ovatus, Phaedon
cochleariae, Phyllotreta chrysocephala, Phyllophaga sp.,
Phyllophaga cuyabana, Phyllophaga triticophaga, Phyllopertha
horticola, Phyllotreta nemorum, Phyllotreta striolata, Popillia
japonica, Sitona lineatus and Sitophllus granaria, dipterans
(Diptera), for example Aedes aegypti, Aedes vexans, Anastrepha
ludens, Anopheles macullpennis, Ceratitis capitata, Chrysomya
bezziana, Chrysomya hominivorax, Chiysomya macellaria, Contarinia
sorghicola, Cordylobia anthropophaga, Culex pipiens, Dacus
cucurbitae, Dacus oleae, Dasineura brassicae, Fannia canlculanis,
Gasterophilus intestina/is, Glossina morsitans, Haematobia
irritans, Haplodiplosis equestris, Hylemyia platura, Hypoderma
lineata, Liriomyza sativae, Liriomyza trifolg Lucilia caprina,
Lucilia cuprina, Lucilia sericata, Lycoria pectoralis, Mayetiola
destructor, Musca domestica, Muscina stabulans, Oestrus ovis,
Oscinella frit, Pegomya hysocyami, Phorbia antiqua, Phorbia
brassicae, Phorbia coarctata, Rhagoletis cerasi, Rhagoletis
pomonella, Tabanus bovinus, Tipula oleracea and Tipula paludosa,
thrips (Thysanoptera), e.g. Frankliniella fusca, Frankliniella
occidentalis, Frankliniella tritict, Scirtothrips citri, Thrips
oryzae, Thrips palmi and Thrips tabaci, hymenopterans
(Hymenoptera), e.g. Acromyrmex ambuguus, Acromyrmex crassispinus,
Acromyrmex heiery, Acromyrmex landolti, Acromyrmex subterraneus,
Athalia rosae, Atta capiguara, Atta cephalotes, Atta laevigata,
Atta robusta, Atta sexdens, Atta texana, Hoplocampa minuta,
Hoplocampa testudinea, Monomorium pharaonis, Solenopsis geminata
and Solenopsis invicta, heteropterans (Heteroptera), e.g.
Acrosternum hllare, Blissus leucopterus, Cyrtopeltis notatus,
Dichelops furcatus, Dysdercus cingulatus, Dysdercus intermedius,
Euchistos heros, Eurygaster integriceps, Euschistus impictiventris,
Leptoglossus phyllopus, Lygus lineolaris, Lygus pratensis, Nezara
viridula, Piesma quadrata, Piezodorus guildini, Solubea insularis
and Thyanta perdilor,
[0430] Hemiptera and Homoptera, e.g. Acrosternum hilare, Blissus
leucopterus, Cyrtopeltis notatus, Diaphorina citric Dysdercus
cingulatus, Dysdercus intermedius, Eurygaster integriceps,
Euschistus impictiventris, Leptoglossus phyllopus, Lygus
lineolaris, Lygus pratensis, Nezara viridula, Piesma quadrata,
Solubea insularis, Thyanta perditor, Acyrthosiphon onoboichis,
Adelges laricis, Aphidula nasturtii, Aphis fabae, Aphis forbest,
Aphis pomi, Aphis gossypii, Aphis grossulariae, Aphis schneideri,
Aphis spiraecola, Aphis sambuci, Acyrthosiphon pisum, Aulacorthum
solani, Brachycaudus cardui, Brachycaudus helichrysi, Brachycaudus
persicae, Brachycaudus prunicola, Brevicoryne brassicae,
Capitophorus horni, Cerosipha gossypii, Chaetosiphon fragaefolii
Cryptomyzus ribis, Dreyfusia nordmannianae, Dreyfusia piceae,
Dysaphis radicola, Dysaulacorthum pseudosolani, Dysaphis
plantaginea, Dysaphis pyri, Empoasca fabae, Hyalopterus Pruni,
Hyperomyzus lactucae, Macrosiphum avenae, Macrosiphum euphorbiae,
Macrosiphon rosae, Megoura viciae, Melanaphis pyrarius,
Metopolophium dirhodum, Myzodes persicae, Myzus ascalonicus, Myzus
cerasi, Myzus varians, Nasonovia ribis-nigri, Nilaparvata lugens,
Pemphigus bursarius, Perkinsiella saccharicida, Phorodon humuli,
Psylla malt, Psylla oiri, Rhopalomyzus ascalonicus, Rhopalosiphum
maidis, Rhopalosiphum padi, Rhopalosiphum insertum, Sappaphis mala,
Sappaphis mali, Schizaphis graminum, Schizoneura lanuginosa,
Sitobion avenae, Trialeurodes vaporarlorum, Toxoptera aurantlland,
Viteus vitlfolli, Cirnex lectularius, Ciinex hemipterus, Reduvius
senilis, Triatoma spp., and Arilus critatus,
termites (Isoptera), e.g. Calotermes flavicollis, Cornitermes
cumulans, Heterotermes tents, Leucotermes flavipes, Neocapritemes
opacus, Procornilermes triacifer; Reticufitermes lucifugus,
Syntermes molestus, and Termes natalensis, orthopterans
(Orthoptera), e.g. Acheta domestica, Blatta orientalis, Blattella
germanica, Forficula auricularia, Gryllotalpa Locusta migratoria,
Melanoplus blvittatus, Melanoplus femur-rubrum, Melanoplus
mexicanus, Melanoplus sanguinipes, Melanoplus spretus, Nomadacris
septemfasciata, Periplaneta americana, Schistocerca americana,
Schistocerca peregrine, Stauronotus maroccanus and Tachycines
asynamorus, Arachnoidea, such as arachnids, e.g. of the families
Argasidae, Ixodidae and Sarcoptidae, such as Amblyomma americanum,
Amblyomma variegatum, Argas persicus, Boophllus annulatus,
Boophilus decoloratus, Boophllus microplus, Dermacentor silvarum,
Hyalomma truncatum, Ixodes ricinus, Ixodes rubicundus, Ornithodorus
moubata, Otobius megnio, Dermanyssus gallinae, Psoroptes ovis,
Rhipicephalus appendiculatus, Rhipicephalus evertsi, Sarcoptes
scabiei, and Eriophyidae spp. such as Aculus schlechtendali,
Phyllocoptrata oleivora and Eriophyes sheldoni; Tarsonemidae spp.
such as Phytonemus pallidus and Polyphagotarsonemus latus;
Tenuipalpidae spp. such as Brevipalpus phoenicis; Tetranychidae
spp. such as Tetranychus cinnabarinus, Tetranychus kanzawai,
Tetranychus pacificus, Tetranychus tetanus and Tetranychus urticae,
Panonychus ulmi, Panonychus citri, and Oligonychus pratensis.
[0431] In particular, the inventive mixtures are suitable for
combating pests of the orders Coleoptera, Lepidoptera,
Thysanoptera, Homoptera, Isoptera, and Orthoptera.
[0432] They are also suitable for controlling the following plant
parasitic nematodes such as root-knot nematodes, Meloidogyne
arenaria, Meloidogyne chitwoodi, Meloidogyne exigua, Meloidogyne
hapla, Meloidogyne incognita, Meloidogyne javanica and other
Meloidogyne species; cyst nematodes, Globodera rostochiensis,
Globodera pallida, Globodera tabacum and other Globodera species,
Heterodera avenae, Heterodera glycines, Heterodera schachtii,
Heterodera trifolii; and other Heterodera species; seed gall
nematodes, Anguina funesta, Anguina tritici and other Anguina
species; stem and foliar nematodes, Aphelenchoides besseyi,
Aphelenchoides fragariae, Aphelenchoides ritzemabosi and other
Aphelenchoides species, sting nematodes, Belonolaimus longicaudatus
and other Belonolaimus species; pine nematodes, Bursaphelenchus
xylophilus and other Bursaphelenchus species, ring nematodes,
Criconema species, Criconemella species, Criconemodes species, and
Mesocriconema species; stem and bulb nematodes, Ditylenchus
destructor, Ditylenchus dipsaci, Ditylenchus myceliophagus and
other Ditylenchus species; awl nematodes, Dolichodorus species;
spiral nematodes, Helicotylenchus dihystera, Helicotylenchus
multicinctus and other Helicotylenchus species, Rotylenchus
robustus and other Rotylenchus species, sheath nematodes,
Hemicycliophora species and Hemicriconemoides species;
Hirshmanniella species; lance nematodes, Hoplolaimus columbus,
Hoplolaimus galeatus and other Hoplolaimus species, false root-knot
nematodes, Nacobbus aberrans and other Nacobbus species; needle
nematodes, Longidorus elongates and other Longidorus species; pin
nematodes, Paratylenchus species; lesion nematodes, Pratylenchus
brachyurus, Pratylenchus coffeae, Pratylenchus curvitatus,
Pratylenchus goodeyi, Pratylencus neglectus, Pratylenchus
penetrans, Pratylenchus scribneri, Pratylenchus vulnus,
Pratylenchus zeae and other Pratylenchus species; Radinaphelenchus
cocophilus and other Radinaphelenchus species, burrowing nematodes,
Radopholus similis and other Radopholus species; reniform
nematodes, Rotylenchulus reniformis and other Rotylenchulus
species; Scutellonema species; stubby root nematodes, Trichodorus
primitivus and other Trichodorus species; Paratrichodorus minor and
other Paratrichodorus species, stunt nematodes, Tylenchorhynchus
claytoni, Tylenchorhynchus dubius and other Tylenchorhynchus
species and Merlinius species; citrus nematodes, Tylenchulus
semipenetrans and other Tylenchulus species; dagger nematodes,
Xiphinema americanum, Xiphinema index, Xiphinema diversicaudatum
and other Xiphinema species, and other plant parasitic nematode
species
[0433] Plant propagation materials may be treated with the mixtures
and compositions of the invention prophylactically either at or
before planting or transplanting.
[0434] In particular, the present invention relates to a method for
protection of plant propagation material from pests, wherein the
plant propagation material is treated with an effective amount of
an inventive mixture.
[0435] In a preferred embodiment, the present invention relates to
a method for protection of plant propagation material from animal
pests (insects, acarids or nematodes), wherein the plant
propagation material are treated with an effective amount of an
inventive mixture.
[0436] In an equally preferred embodiment, the present invention
relates to a method for protection of plant propagation material
from harmful fungi, wherein the plant propagation material is
treated with an effective amount of an inventive mixture.
[0437] In general, "pesticidally effective amount" means the amount
of the inventive mixtures or of compositions comprising the
mixtures needed to achieve an observable effect on growth,
including the effects of necrosis, death, retardation, prevention,
and removal, destruction, or otherwise diminishing the occurrence
and activity of the target organism. The pesticidally effective
amount can vary for the various mixtures/compositions used in the
invention. A pesticidally effective amount of the
mixtures/compositions will also vary according to the prevailing
conditions such as desired pesticidal effect and duration, weather,
target species, locus, mode of application, and the like.
[0438] In an equally preferred embodiment, the present invention
relates to a method for improving the nitrification-inhibiting
effect, wherein the seeds, the plants or the soil are treated with
a NI effective amount of an inventive mixture.
[0439] The term "NI effective amount" denotes an amount of the
inventive mixtures, which is sufficient for achieving
nitrification-inhibiting effects as defined herein below. More
exemplary information about amounts, ways of application and
suitable ratios to be used is given below. Anyway, the skilled
artisan is well aware of the fact that such an amount can vary in a
broad range and is dependent on various factors, e.g. weather,
target species, locus, mode of application, soil type, the treated
cultivated plant or material and the climatic conditions.
[0440] According to the present invention, the
nitrification-inhibiting effect is increased by at least 2%, more
preferably by at least 4%, most preferably at least 7%,
particularly preferably at least 10%, more particularly preferably
by at least 15%, most particularly preferably by at least 20%,
particularly more preferably by at least 25%, particularly most
preferably by at least 30%, particularly by at least 35%,
especially more preferably by at least 40%, especially most
preferably by at least 45%, especially by at least 50%, in
particular preferably by at least 55%, in particular more
preferably by at least 60%, in particular most preferably by at
least 65%, in particular by at least 70%, for example by at least
75%. In general, the increase of the nitrification-inhibiting
effect may be for example 5 to 10%, more preferably 10 to 20%, most
preferably 20 to 30%. The nitrification-inhibiting effect can be
measured according to Example 1 and 2 as shown below:
EXAMPLE 1
[0441] The compositions and mixtures of the invention have been
tested as follows in terms of the inhibition of nitrification:
[0442] Soil was sampled fresh from a field (e.g. Limburgerhof),
dried and sieved through a 500 .mu.m sieve. Approximately 200 mg of
soil were placed into each well of a 48 well plate. The
compositions or mixtures of the invention, or DMSO alone, were
added at a concentration of 10 ppm, dissolved in 1% DMSO. 6 .mu.mol
ammonium sulfate was added per well as well as 4.8 mg
NaClO.sub.3.
[0443] Subsequently, the samples were incubated at room temperature
for up to 72 hrs. After the incubation period 64 mg KCl were added
and mixed. 25 .mu.l of the supernatant were placed into a fresh
plate and 260 .mu.l of a color reaction solution (from Merck Nr
1.11799.0100) were added.
[0444] Measurements were taken with a Tecan plate Reader at 540 nm
wavelength.
EXAMPLE 2: (FOR THOSE RESULTS WITH A % INHIBITION AND NOT RESULTS
IN PPM)
[0445] 100 g soil is filled into 500 ml plastic bottles (e.g. soil
sampled from the field) and is moistened to 50% water holding
capacity. The soil is incubated at 20.degree. C. for two weeks to
activate the microbial biomass. 1 ml test solution, containing the
compositions and mixtures of the invention in the appropriate
concentration (usually 0.3 or 1% of nitrogen N), or DMSO and 10 mg
nitrogen in the form of ammoniumsulfate-N is added to the soil and
everything mixed well. Bottles are capped but loosely to allow air
exchange. The bottles are then incubated at 20.degree. C. for 0 and
14 days.
[0446] For analysis, 300 ml of a 1% K2SO4-solution is added to the
bottle containing the soil and shaken for 2 hrs in a horizontal
shaker at 150 rpm. Then the whole solution is filtered through a
Macherey-Nagel Filter MN 807 1/4. Ammonium and nitrate content is
then analyzed in the filtrate in an autoanalyzer at 550 nm (Merck,
AA11).
Calculations:
[0447] inhibition in % = ( NO 3 -- N without NI at end of
incubation - NO 3 -- N with NI at end of incubation ) ( NO 3 -- N
without NI at end of incubation - NO 3 -- N at beginning ) .times.
100 ##EQU00001##
[0448] In an equally preferred embodiment, the present invention
relates to a method for improving the health of plants, wherein the
plants are treated with a plant health effective amount of an
inventive mixture.
[0449] The term "plant health effective amount" denotes an amount
of the inventive mixtures, which is sufficient for achieving plant
health effects as defined herein below. More exemplary information
about amounts, ways of application and suitable ratios to be used
is given below. Anyway, the skilled artisan is well aware of the
fact that such an amount can vary in a broad range and is dependent
on various factors, e.g. the treated cultivated plant or material
and the climatic conditions.
[0450] Healthier plants are desirable since they result among
others in better yields and/or a better quality of the plants or
crops, specifically better quality of the harvested plant parts.
Healthier plants also better resist to biotic and/or abiotic
stress. A high resistance against biotic stresses in turn allows
the person skilled in the art to reduce the quantity of pesticides
applied and consequently to slow down the development of
resistances against the respective pesticides.
[0451] It has to be emphasized that the above mentioned effects of
the inventive mixtures, i.e. enhanced health of the plant, are also
present when the plant is not under biotic stress and in particular
when the plant is not under pest pressure.
[0452] For example, for seed treatment and soil applications, it is
evident that a plant suffering from fungal or insecticidal attack
shows reduced germination and emergence leading to poorer plant or
crop establishment and vigor, and consequently, to a reduced yield
as compared to a plant propagation material which has been
subjected to curative or preventive treatment against the relevant
pest and which can grow without the damage caused by the biotic
stress factor.
[0453] However, the methods according to the invention lead to an
enhanced plant health even in the absence of any biotic stress.
This means that the positive effects of the mixtures of the
invention cannot be explained just by the pesticidal activities of
the compounds I and compounds II, but are based on further activity
profiles. Accordingly, the application of the inventive mixtures
can also be carried out in the absence of pest pressure.
[0454] In an equally preferred embodiment, the present invention
relates to a method for improving the health of plants grown from
said plant propagation material, wherein the plant propagation
material is treated with an effective amount of an inventive
mixture.
[0455] Each plant health indicator listed below, which is selected
from the groups consisting of yield, plant vigor, quality and
tolerance of the plant to abiotic and/or biotic stress, is to be
understood as a preferred embodiment of the present invention
either each on its own or preferably in combination with each
other.
[0456] According to the present invention, "increased yield" of a
plant means that the yield of a product of the respective plant is
increased by a measurable amount over the yield of the same product
of the plant produced under the same conditions, but without the
application of the inventive mixture.
[0457] For seed treatment e.g. as inoculant and/or foliar
application forms, increased yield can be characterized, among
others, by the following improved properties of the plant:
increased plant weight; and/or increased plant height; and/or
increased biomass such as higher overall fresh weight (FW) or dry
weight (DW); and/or increased number of flowers per plant; and/or
higher grain and/or fruit yield; and/or more tillers or side shoots
(branches); and/or larger leaves; and/or increased shoot growth;
and/or increased protein content; and/or increased oil content;
and/or increased starch content; and/or increased pigment content;
and/or increased chlorophyll content (chlorophyll content has a
positive correlation with the plant's photosynthesis rate and
accordingly, the higher the chlorophyll content the higher the
yield of a plant) and/or increased quality of a plant; and/or
better nitrogen uptake (N uptake).
[0458] "Grain" and "fruit" are to be understood as any plant
product which is further utilized after harvesting, e.g. fruits in
the proper sense, vegetables, nuts, grains, seeds, wood (e.g. in
the case of silviculture plants), flowers (e.g. in the case of
gardening plants, ornamentals) etc., that is anything of economic
value that is produced by the plant.
[0459] According to the present invention, the yield is increased
by at least 2%, more preferably by at least 4%, most preferably at
least 7%, particularly preferably at least 10%, more particularly
preferably by at least 15%, most particularly preferably by at
least 20%, particularly more preferably by at least 25%,
particularly most preferably by at least 30%, particularly by at
least 35%, especially more preferably by at least 40%, especially
most preferably by at least 45%, especially by at least 50%, in
particular preferably by at least 55%, in particular more
preferably by at least 60%, in particular most preferably by at
least 65%, in particular by at least 70%, for example by at least
75%.
[0460] According to the present invention, the yield--if measured
in the absence of pest pressure--is increased by at least 2%, more
preferably by at least 4%, most preferably at least 7%,
particularly preferably at least 10%, more particularly preferably
by at least 15%, most particularly preferably by at least 20%,
particularly more preferably by at least 25%, particularly most
preferably by at least 30%, particularly by at least 35%,
especially more preferably by at least 40%, especially most
preferably by at least 45%, especially by at least 50%, in
particular preferably by at least 55%, in particular more
preferably by at least 60%, in particular most preferably by at
least 65%, in particular by at least 70%, for example by at least
75%.
[0461] Another indicator for the condition of the plant is the
plant vigor. The plant vigor becomes manifest in several aspects
such as the general visual appearance.
[0462] For foliar applications, improved plant vigor can be
characterized, among others, by the following improved properties
of the plant: improved vitality of the plant; and/or improved plant
growth; and/or improved plant development; and/or improved visual
appearance; and/or improved plant stand (less plant verse/lodging
and/or bigger leaf blade; and/or bigger size; and/or increased
plant height; and/or increased tiller number; and/or increased
number of side shoots; and/or increased number of flowers per
plant; and/or increased shoot growth; and/or enhanced
photosynthetic activity (e.g. based on increased stomatal
conductance and/or increased CO.sub.2 assimilation rate)); and/or
earlier flowering; and/or earlier fruiting; and/or earlier grain
maturity; and/or less non-productive tillers; and/or less dead
basal leaves; and/or less input needed (such as fertilizers or
water); and/or greener leaves; and/or complete maturation under
shortened vegetation periods; and/or easier harvesting; and/or
faster and more uniform ripening; and/or longer shelf-life; and/or
longer panicles; and/or delay of senescence; and/or stronger and/or
more productive tillers; and/or better extractability of
ingredients; and/or improved quality of seeds (for being seeded in
the following seasons for seed production); and/or reduced
production of ethylene and/or the inhibition of its reception by
the plant.
[0463] Another indicator for the condition of the plant is the
"quality" of a plant and/or its products. According to the present
invention, enhanced quality means that certain plant
characteristics such as the content or composition of certain
ingredients are increased or improved by a measurable or noticeable
amount over the same factor of the plant produced under the same
conditions, but without the application of the mixtures of the
present invention. Enhanced quality can be characterized, among
others, by following improved properties of the plant or its
product: increased nutrient content; and/or increased protein
content; and/or increased oil content; and/or increased starch
content; and/or increased content of fatty acids; and/or increased
metabolite content; and/or increased carotenoid content; and/or
increased sugar content; and/or increased amount of essential amino
acids; and/or improved nutrient composition; and/or improved
protein composition; and/or improved composition of fatty acids;
and/or improved metabolite composition; and/or improved carotenoid
composition; and/or improved sugar composition; and/or improved
amino acids composition; and/or improved or optimal fruit color;
and/or improved leaf color; and/or higher storage capacity; and/or
better processability of the harvested products.
[0464] Another indicator for the condition of the plant is the
plant's tolerance or resistance to biotic and/or abiotic stress
factors. Biotic and abiotic stress, especially over longer terms,
can have harmful effects on plants.
[0465] Biotic stress is caused by living organisms while abiotic
stress is caused for example by environmental extremes. According
to the present invention, "enhanced tolerance or resistance to
biotic and/or abiotic stress factors" means (1.) that certain
negative factors caused by biotic and/or abiotic stress are
diminished in a measurable or noticeable amount as compared to
plants exposed to the same conditions, but without being treated
with an inventive mixture and (2.) that the negative effects are
not diminished by a direct action of the inventive mixture on the
stress factors, e.g. by its fungicidal or insecticidal action which
directly destroys the microorganisms or pests, but rather by a
stimulation of the plants' own defensive reactions against said
stress factors.
[0466] Negative factors caused by biotic stress such as pathogens
and pests are widely known and are caused by living organisms, such
as competing plants (for example weeds), microorganisms (such as
phytopathogenic fungi and/or bacteria) and/or viruses.
[0467] Negative factors caused by abiotic stress are also
well-known and can often be observed as reduced plant vigor (see
above), for example:
less yield and/or less vigor, for both effects examples can be
burned leaves, less flowers, premature ripening, later crop
maturity, reduced nutritional value amongst others.
[0468] Abiotic stress can be caused for example by: extremes in
temperature such as heat or cold (heat stress/cold stress); and/or
strong variations in temperature; and/or temperatures unusual for
the specific season; and/or drought (drought stress); and/or
extreme wetness; and/or high salinity (salt stress); and/or
radiation (for example by increased UV radiation due to the
decreasing ozone layer); and/or increased ozone levels (ozone
stress); and/or organic pollution (for example by phytotoxic
amounts of pesticides); and/or inorganic pollution (for example by
heavy metal contaminants).
[0469] As a result of biotic and/or abiotic stress factors, the
quantity and the quality of the stressed plants decrease. As far as
quality (as defined above) is concerned, reproductive development
is usually severely affected with consequences on the crops which
are important for fruits or seeds. Synthesis, accumulation and
storage of proteins are mostly affected by temperature; growth is
slowed by almost all types of stress; polysaccharide synthesis,
both structural and storage is reduced or modified: these effects
result in a decrease in biomass (yield) and in changes in the
nutritional value of the product.
[0470] As pointed out above, the above identified indicators for
the health condition of a plant may be interdependent and may
result from each other. For example, an increased resistance to
biotic and/or abiotic stress may lead to a better plant vigor, e.g.
to better and bigger crops, and thus to an increased yield.
Inversely, a more developed root system may result in an increased
resistance to biotic and/or abiotic stress. However, these
interdependencies and interactions are neither all known nor fully
understood and therefore the different indicators are described
separately.
[0471] In one embodiment the inventive mixtures effectuate an
increased yield of a plant or its product. In another embodiment
the inventive mixtures effectuate an increased vigor of a plant or
its product. In another embodiment the inventive mixtures
effectuate in an increased quality of a plant or its product. In
yet another embodiment the inventive mixtures effectuate an
increased tolerance and/or resistance of a plant or its product
against biotic stress. In yet another embodiment the inventive
mixtures effectuate an increased tolerance and/or resistance of a
plant or its product against abiotic stress.
[0472] The invention also relates to agrochemical compositions
comprising an auxiliary and at least one compound I and at least
one compound II, or a cell-free extract of compound II or at least
one metabolite thereof having pesticidal activity, and/or a mutant
of compound II having pesticidal activity and producing at least
one pesticidal metabolite as defined herein, or a pesticidal
metabolite or extract of the mutant, and at least one pesticide II
according to the invention.
[0473] An agrochemical composition comprises a NI effective amount
or plant health effective amount of compound I. Such an amount can
vary in a broad range and is dependent on various factors, e.g.
weather, target species, locus, mode of application, soil type, the
treated cultivated plant or material and the climatic
conditions.
[0474] An agrochemical composition comprises a fungicidally or
insecticidally or plant health effective amount of compound II, or
a cell-free extract thereof or at least one metabolite thereof
having pesticidal activity, and/or a mutant of compound II having
pesticidal activity and producing at least one pesticidal
metabolite as defined herein, or a pesticidal metabolite or extract
of the mutant, and at least one pesticide II. Such an amount can
vary in a broad range and is dependent on various factors, such as
the fungal or pest species to be controlled, the treated cultivated
plant or material, the climatic conditions.
[0475] In the case of mixtures comprising microbial pesticides II
selected from groups L1), L3) and L5), the microorganisms as used
according to the invention can be cultivated continuously or
discontinuously in the batch process or in the fed batch or
repeated fed batch process. A review of known methods of
cultivation will be found in the textbook by Chmiel
(Bioprozesstechnik 1. Einfuhrung in die Bioverfahrenstechnik
(Gustav Fischer Verlag, Stuttgart, 1991)) or in the textbook by
Storhas (Bioreaktoren and periphere Einrichtungen (Vieweg Verlag,
Braunschweig/Wiesbaden, 1994)). The culture medium that is to be
used must satisfy the requirements of the particular strains in an
appropriate manner. Descriptions of culture media for various
microorganisms are given in the handbook "Manual of Methods for
General Bacteriology" of the American Society for Bacteriology
(Washington D. C., USA, 1981). These culture media that can be used
according to the invention generally comprise one or more sources
of carbon, sources of nitrogen, inorganic salts, vitamins and/or
trace elements. Preferred sources of carbon are sugars, such as
mono-, di- or polysaccharides. Very good sources of carbon are for
example glucose, fructose, mannose, galactose, ribose, sorbose,
ribulose, lactose, maltose, sucrose, raffinose, starch or
cellulose. Sugars can also be added to the media via complex
compounds, such as molasses, or other by-products from sugar
refining. It may also be advantageous to add mixtures of various
sources of carbon. Other possible sources of carbon are oils and
fats such as soybean oil, sunflower oil, peanut oil and coconut
oil, fatty acids such as palmitic acid, stearic acid or linoleic
acid, alcohols such as glycerol, methanol or ethanol and organic
acids such as acetic acid or lactic acid. Sources of nitrogen are
usually organic or inorganic nitrogen compounds or materials
containing these compounds. Examples of sources of nitrogen include
ammonia gas or ammonium salts, such as ammonium sulfate, ammonium
chloride, ammonium phosphate, ammonium carbonate or ammonium
nitrate, nitrates, urea, amino acids or complex sources of
nitrogen, such as corn-steep liquor, soybean flour, soybean
protein, yeast extract, meat extract and others. The sources of
nitrogen can be used separately or as a mixture. Inorganic salt
compounds that may be present in the media comprise the chloride,
phosphate or sulfate salts of calcium, magnesium, sodium, cobalt,
molybdenum, potassium, manganese, zinc, copper and iron. Inorganic
sulfur-containing compounds, for example sulfates, sulfites,
dithionites, tetrathionates, thiosulfates, sulfides, but also
organic sulfur compounds, such as mercaptans and thiols, can be
used as sources of sulfur. Phosphoric acid, potassium
dihydrogenphosphate or dipotassium hydrogenphosphate or the
corresponding sodium-containing salts can be used as sources of
phosphorus. Chelating agents can be added to the medium, in order
to keep the metal ions in solution. Especially suitable chelating
agents comprise dihydroxyphenols, such as catechol or
protocatechuate, or organic acids, such as citric acid. The culture
media used may also contain other growth factors, such as vitamins
or growth promoters, which include for example biotin, riboflavin,
thiamine, folic acid, nicotinic acid, pantothenate and pyridoxine.
Growth factors and salts often come from complex components of the
media, such as yeast extract, molasses, corn-steep liquor and the
like. In addition, suitable precursors can be added to the culture
medium. The precise composition of the compounds in the medium is
strongly dependent on the particular experiment and must be decided
individually for each specific case. Information on media
optimization can be found in the textbook "Applied Microbiol.
Physiology, A Practical Approach" (Publ. P. M. Rhodes, P. F.
Stanbury, IRL Press (1997) p. 53-73, ISBN 0 19 963577 3). Growing
media can also be obtained from commercial suppliers, such as
Standard 1 (Merck) or BHI (Brain heart infusion, DIFCO) etc. All
components of the medium are sterilized, either by heating (20 min
at 2.0 bar and 121.degree. C.) or by sterile filtration. The
components can be sterilized either together, or if necessary
separately. All the components of the medium can be present at the
start of growing, or optionally can be added continuously or by
batch feed. The temperature of the culture of the respective
microorganism is normally between 15.degree. C. and 45.degree. C.,
preferably 25.degree. C. to 40.degree. C. and can be kept constant
or can be varied during the experiment. The pH value of the medium
should be in the range from 5 to 8.5, preferably around 7.0. The pH
value for growing can be controlled during growing by adding basic
compounds such as sodium hydroxide, potassium hydroxide, ammonia or
ammonia water or acid compounds such as phosphoric acid or sulfuric
acid. Antifoaming agents, e.g. fatty acid polyglycol esters, can be
used for controlling foaming. To maintain the stability of
plasmids, suitable substances with selective action, e.g.
antibiotics, can be added to the medium. Oxygen or
oxygen-containing gas mixtures, e.g. the ambient air, are fed into
the culture in order to maintain aerobic conditions. The
temperature of the culture is normally from 20.degree. C. to
45.degree. C. Culture is continued until a maximum of the desired
product has formed. This is normally achieved within 10 hours to
160 hours. To obtain cell-free extracts, the cells can be disrupted
optionally by high-frequency ultrasound, by high pressure, e.g. in
a French pressure cell, by osmolysis, by the action of detergents,
lytic enzymes or organic solvents, by means of homogenizers or by a
combination of several of the methods listed. The methodology of
the present invention can further include a step of recovering
individual compositions such as cell-free extracts, supernatants,
metabolites or alike. The term "recovering" includes extracting,
harvesting, isolating or purifying of an extract, supernatant or
metabolite e.g. from whole culture broth. Recovering can be
performed according to any conventional isolation or purification
methodology known in the art including, but not limited to,
treatment with a conventional resin (e.g., anion or cation exchange
resin, nonionic adsorption resin, etc.), treatment with a
conventional adsorbent (e.g., activated charcoal, silicic acid,
silica gel, cellulose, alumina, etc.), alteration of pH, solvent
extraction (e.g., with a conventional solvent such as an alcohol,
ethyl acetate, hexane and the like), distillation, dialysis,
filtration, concentration, crystallization, recrystallization, pH
adjustment, lyophilization and the like. For example the agent can
be recovered from culture media by first removing the
microorganisms. The remaining broth is then passed through or over
a cation exchange resin to remove unwanted cations and then through
or over an anion exchange resin to remove unwanted inorganic anions
and organic acids.
[0476] According to one embodiment, individual components of the
composition according to the invention such as parts of a kit or
parts of a binary or ternary mixture may be mixed by the user
himself in a spray tank or any other kind of vessel used for
applications (e.g seed treater drums, seed pelleting machinery,
knapsack sprayer) and further auxiliaries may be added, if
appropriate. When living microorganisms, such as compounds II from
groups L1), L3) and L5), form part of such kit, it must be taken
care that choice and amounts of the other parts of the kit (e.g.
chemical pesticidal agents) and of the further auxiliaries should
not influence the viability of the microbial pesticides in the
composition mixed by the user. Especially for bactericides and
solvents, compatibility with the respective microbial pesticide has
to be taken into account.
[0477] Consequently, one embodiment of the invention is a kit for
preparing a usable pesticidal composition, the kit comprising a) a
composition comprising compound I as defined herein and at least
one auxiliary; and b) a composition comprising compound II as
defined herein and at least one auxiliary; and optionally c) a
composition comprising at least one auxiliary and optionally a
further active component III as defined herein.
[0478] The compounds according to the invention can be converted
into customary types of agrochemical compositions, e.g. solutions,
emulsions, suspensions, dusts, powders, pastes, granules,
pressings, capsules, and mixtures thereof. Examples for composition
types are suspensions (e.g. SC, OD, FS), emulsifiable concentrates
(e.g. EC), emulsions (e.g. EW, EO, ES, ME), capsules (e.g. CS, ZC),
pastes, pastilles, wettable powders or dusts (e.g. WP, SP, WS, DP,
DS), pressings (e.g. BR, TB, DT), granules (e.g. WG, SG, GR, FG,
GG, MG), insecticidal articles (e.g. LN), as well as gel
formulations for the treatment of plant propagation materials such
as seeds (e.g. GF). These and further compositions types are
defined in the "Catalogue of pesticide formulation types and
international coding system", Technical Monograph No. 2, 6th Ed.
May 2008, CropLife International.
[0479] The compositions are prepared in a known manner, such as
described by Mollet and Grubemann, Formulation technology, Wiley
VCH, Weinheim, 2001; or Knowles, New developments in crop
protection product formulation, Agrow Reports DS243, T&F
Informa, London, 2005.
[0480] Suitable auxiliaries are solvents, liquid carriers, solid
carriers or fillers, surfactants, dispersants, emulsifiers,
wetters, adjuvants, solubilizers, penetration enhancers, protective
colloids, adhesion agents, thickeners, humectants, repellents,
attractants, feeding stimulants, compatibilizers, bactericides,
anti-freezing agents, anti-foaming agents, colorants, tackifiers
and binders.
[0481] Suitable solvents and liquid carriers are water and organic
solvents, such as mineral oil fractions of medium to high boiling
point, e.g. kerosene, diesel oil; oils of vegetable or animal
origin; aliphatic, cyclic and aromatic hydrocarbons, e.g. toluene,
paraffin, tetrahydronaphthalene, alkylated naphthalenes; alcohols,
e.g. ethanol, propanol, butanol, benzylalcohol, cyclohexanol;
glycols; DMSO; ketones, e.g. cyclohexanone; esters, e.g. lactates,
carbonates, fatty acid esters, gamma-butyrolactone; fatty acids;
phosphonates; amines; amides, e.g. N-methylpyrrolidone, fatty acid
dimethylamides; and mixtures thereof.
[0482] Suitable solid carriers or fillers are mineral earths, e.g.
silicates, silica gels, talc, kaolins, limestone, lime, chalk,
clays, dolomite, diatomaceous earth, bentonite, calcium sulfate,
magnesium sulfate, magnesium oxide; polysaccharides, e.g.
cellulose, starch; fertilizers, e.g. ammonium sulfate, ammonium
phosphate, ammonium nitrate, ureas; products of vegetable origin,
e.g. cereal meal, tree bark meal, wood meal, nutshell meal, and
mixtures thereof.
[0483] Suitable surfactants are surface-active compounds, such as
anionic, cationic, nonionic and amphoteric surfactants, block
polymers, polyelectrolytes, and mixtures thereof. Such surfactants
can be used as emulsifier, dispersant, solubilizer, wetter,
penetration enhancer, protective colloid, or adjuvant. Examples of
surfactants are listed in McCutcheon's, Vol. 1: Emulsifiers &
Detergents, McCutcheon's Directories, Glen Rock, USA, 2008
(International Ed. or North American Ed.).
[0484] Suitable anionic surfactants are alkali, alkaline earth or
ammonium salts of sulfonates, sulfates, phosphates, carboxylates,
and mixtures thereof. Examples of sulfonates are
alkylarylsulfonates, diphenylsulfonates, alpha-olefin sulfonates,
lignine sulfonates, sulfonates of fatty acids and oils, sulfonates
of ethoxylated alkylphenols, sulfonates of alkoxylated arylphenols,
sulfonates of condensed naphthalenes, sulfonates of dodecyl- and
tridecylbenzenes, sulfonates of naphthalenes and alkylnaphthalenes,
sulfosuccinates or sulfosuccinamates. Examples of sulfates are
sulfates of fatty acids and oils, of ethoxylated alkylphenols, of
alcohols, of ethoxylated alcohols, or of fatty acid esters.
Examples of phosphates are phosphate esters. Examples of
carboxylates are alkyl carboxylates, and carboxylated alcohol or
alkylphenol ethoxylates.
[0485] Suitable nonionic surfactants are alkoxylates, N-substituted
fatty acid amides, amine oxides, esters, sugar-based surfactants,
polymeric surfactants, and mixtures thereof. Examples of
alkoxylates are compounds such as alcohols, alkylphenols, amines,
amides, arylphenols, fatty acids or fatty acid esters which have
been alkoxylated with 1 to 50 equivalents. Ethylene oxide and/or
propylene oxide may be employed for the alkoxylation, preferably
ethylene oxide. Examples of N-substituted fatty acid amides are
fatty acid glucamides or fatty acid alkanolamides. Examples of
esters are fatty acid esters, glycerol esters or monoglycerides.
Examples of sugar-based surfactants are sorbitans, ethoxylated
sorbitans, sucrose and glucose esters or alkylpolyglucosides.
Examples of polymeric surfactants are home- or copolymers of vinyl
pyrrolidone, vinylalcohols, or vinylacetate.
[0486] Suitable cationic surfactants are quaternary surfactants,
for example quaternary ammonium compounds with one or two
hydrophobic groups, or salts of long-chain primary amines. Suitable
amphoteric surfactants are alkylbetains and imidazolines. Suitable
block polymers are block polymers of the A-B or A-B-A type
comprising blocks of polyethylene oxide and polypropylene oxide, or
of the A-B--C type comprising alkanol, polyethylene oxide and
polypropylene oxide. Suitable polyelectrolytes are polyacids or
polybases. Examples of polyacids are alkali salts of polyacrylic
acid or polyacid comb polymers. Examples of polybases are
polyvinylamines or polyethyleneamines.
[0487] Suitable adjuvants are compounds, which have a neglectable
or even no pesticidal activity themselves, and which improve the
biological performance of the compound I on the target. Examples
are surfactants, mineral or vegetable oils, and other auxilaries.
Further examples are listed by Knowles, Adjuvants and additives,
Agrow Reports DS256, T&F Informa UK, 2006, chapter 5.
[0488] Suitable thickeners are polysaccharides (e.g. xanthan gum,
carboxymethylcellulose), anorganic clays (organically modified or
unmodified), polycarboxylates, and silicates.
[0489] Suitable bactericides are bronopol and isothiazolinone
derivatives such as alkylisothiazolinones and benzisothiazolinones.
Suitable anti-freezing agents are ethylene glycol, propylene
glycol, urea and glycerin. Suitable anti-foaming agents are
silicones, long chain alcohols, and salts of fatty acids. Suitable
colorants (e.g. in red, blue, or green) are pigments of low water
solubility and water-soluble dyes. Examples are inorganic colorants
(e.g. iron oxide, titan oxide, iron hexacyanoferrate) and organic
colorants (e.g. alizarin-, azo- and phthalocyanine colorants).
Suitable tackifiers or binders are polyvinylpyrrolidons,
polyvinylacetates, polyvinyl alcohols, polyacrylates, biological or
synthetic waxes, and cellulose ethers.
[0490] When living microorganisms, such as biopesticides from
groups L1), L3) and L5), form part of the compositions, such
compositions can be prepared as compositions comprising besides the
active ingredients at least one auxiliary (inert ingredient) by
usual means (see e.g. H. D. Burges: Formulation of Micobial
Biopestcides, Springer, 1998). Suitable customary types of such
compositions are suspensions, dusts, powders, pastes, granules,
pressings, capsules, and mixtures thereof. Examples for composition
types are suspensions (e.g. SC, OD, FS), capsules (e.g. CS, ZC),
pastes, pastilles, wettable powders or dusts (e.g. WP, SP, WS, DP,
DS), pressings (e.g. BR, TB, DT), granules (e.g. WG, SG, GR, FG,
GG, MG), insecticidal articles (e.g. LN), as well as gel
formulations for the treatment of plant propagation materials such
as seeds (e.g. GF). Herein, it has to be taken into account that
each formulation type or choice of auxiliary should not influence
the viability of the microorganism during storage of the
composition and when finally applied to the soil, plant or plant
propagation material. Suitable formulations are e.g. mentioned in
WO2008/002371, U.S. Pat. Nos. 6,955,912, 5,422,107.
[0491] Examples for suitable auxiliaries are those mentioned
earlier herein, wherein it must be taken care that choice and
amounts of such auxiliaries should not influence the viability of
the microbial pesticides in the composition. Especially for
bactericides and solvents, compatibility with the respective
microorganism of the respective microbial pesticide has to be taken
into account. In addition, compositions with microbial pesticides
may further contain stabilizers or nutrients and UV protectants.
Suitable stabilizers or nutrients are e.g. alpha-tocopherol,
trehalose, glutamate, potassium sorbate, various sugars like
glucose, sucrose, lactose and maltodextrine (H. D. Burges:
Formulation of Micobial Biopestcides, Springer, 1998). Suitable UV
protectants are e.g. inorganic compounds like titan dioxide, zinc
oxide and iron oxide pigments or organic compounds like
benzophenones, benzotriazoles and phenyltriazines. The compositions
may in addition to auxiliaries mentioned for compositions
comprising compounds I herein optionally comprise 0.1-80%
stabilizers or nutrients and 0.1-10% UV protectants.
[0492] Examples for composition types and their preparation
are:
i) Water-soluble concentrates (SL, LS)
[0493] 10-60 wt % of a compound I and 5-15 wt % wetting agent (e.g.
alcohol alkoxylates) are dissolved in water and/or in a
water-soluble solvent (e.g. alcohols) ad 100 wt %. The active
substance dissolves upon dilution with water.
ii) Dispersible concentrates (DC)
[0494] 5-25 wt % of a compound I and 1-10 wt % dispersant (e.g.
polyvinylpyrrolidone) are dissolved in organic solvent (e.g.
cyclohexanone) ad 100 wt %. Dilution with water gives a
dispersion.
iii) Emulsifiable concentrates (EC)
[0495] 15-70 wt % of a compound I and 5-10 wt % emulsifiers (e.g.
calcium dodecylbenzenesulfonate and castor oil ethoxylate) are
dissolved in water-insoluble organic solvent (e.g. aromatic
hydrocarbon) ad 100 wt %. Dilution with water gives an
emulsion.
iv) Emulsions (EW, EO, ES)
[0496] 5-40 wt % of a compound I and 1-10 wt % emulsifiers (e.g.
calcium dodecylbenzenesulfonate and castor oil ethoxylate) are
dissolved in 20-40 wt % water-insoluble organic solvent (e.g.
aromatic hydrocarbon). This mixture is introduced into water ad 100
wt % by means of an emulsifying machine and made into a homogeneous
emulsion. Dilution with water gives an emulsion.
v) Suspensions (SC, OD, FS)
[0497] In an agitated ball mill, 20-60 wt % of a compound I are
comminuted with addition of 2-10 wt % dispersants and wetting
agents (e.g. sodium lignosulfonate and alcohol ethoxylate), 0.1-2
wt % thickener (e.g. xanthan gum) and water ad 100 wt % to give a
fine active substance suspension. Dilution with water gives a
stable suspension of the active substance. For FS type composition
up to 40 wt % binder (e.g. polyvinylalcohol) is added.
vi) Water-dispersible granules and water-soluble granules (WG,
SG)
[0498] 50-80 wt % of a compound I are ground finely with addition
of dispersants and wetting agents (e.g. sodium lignosulfonate and
alcohol ethoxylate) ad 100 wt % and prepared as water-dispersible
or water-soluble granules by means of technical appliances (e.g.
extrusion, spray tower, fluidized bed). Dilution with water gives a
stable dispersion or solution of the active substance.
vii) Water-dispersible powders and water-soluble powders (WP, SP,
WS)
[0499] 50-80 wt % of a compound I are ground in a rotor-stator mill
with addition of 1-5 wt % dispersants (e.g. sodium lignosulfonate),
1-3 wt % wetting agents (e.g. alcohol ethoxylate) and solid carrier
(e.g. silica gel) ad 100 wt %. Dilution with water gives a stable
dispersion or solution of the active substance.
viii) Gel (GW, GF)
[0500] In an agitated ball mill, 5-25 wt % of a compound I are
comminuted with addition of 3-10 wt % dispersants (e.g. sodium
lignosulfonate), 1-5 wt % thickener (e.g. carboxymethylcellulose)
and water ad 100 wt % to give a fine suspension of the active
substance. Dilution with water gives a stable suspension of the
active substance.
ix) Microemulsion (ME)
[0501] 5-20 wt % of a compound I are added to 5-30 wt % organic
solvent blend (e.g. fatty acid dimethylamide and cyclohexanone),
10-25 wt % surfactant blend (e.g. alcohol ethoxylate and arylphenol
ethoxylate), and water ad 100%. This mixture is stirred for 1 h to
produce spontaneously a thermodynamically stable microemulsion.
x) Microcapsules (CS)
[0502] An oil phase comprising 5-50 wt % of a compound I, 0-40 wt %
water insoluble organic solvent (e.g. aromatic hydrocarbon), 2-15
wt % acrylic monomers (e.g. methylmethacrylate, methacrylic acid
and a di- or triacrylate) are dispersed into an aqueous solution of
a protective colloid (e.g. polyvinyl alcohol). Radical
polymerization initiated by a radical initiator results in the
formation of poly(meth)acrylate microcapsules. Alternatively, an
oil phase comprising 5-50 wt % of a compound I according to the
invention, 0-40 wt % water insoluble organic solvent (e.g. aromatic
hydrocarbon), and an isocyanate monomer (e.g.
diphenylmethene-4,4'-diisocyanatae) are dispersed into an aqueous
solution of a protective colloid (e.g. polyvinyl alcohol). The
addition of a polyamine (e.g. hexamethylenediamine) results in the
formation of polyurea microcapsules. The monomers amount to 1-10 wt
%. The wt % relate to the total CS composition.
xi) Dustable powders (DP, DS)
[0503] 1-10 wt % of a compound I are ground finely and mixed
intimately with solid carrier (e.g. finely divided kaolin) ad 100
wt %.
xii) Granules (GR, FG)
[0504] 0.5-30 wt % of a compound I is ground finely and associated
with solid carrier (e.g. silicate) ad 100 wt %. Granulation is
achieved by extrusion, spray-drying or fluidized bed.
xiii) Ultra-low volume liquids (UL)
[0505] 1-50 wt % of a compound I are dissolved in organic solvent
(e.g. aromatic hydrocarbon) ad 100 wt %.
[0506] The compositions types i) to xiii) may optionally comprise
further auxiliaries, such as 0.1-1 wt % bactericides, 5-15 wt %
anti-freezing agents, 0.1-1 wt % anti-foaming agents, and 0.1-1 wt
% colorants.
[0507] The compositions types i) to vii) may optionally comprise
further auxiliaries, such as 0.1-1 wt % bactericides, 5-15 wt %
anti-freezing agents, 0.1-1 wt % anti-foaming agents, 0.1-80%
stabilizers or nutrients, 0.1-10% UV protectants and 0.1-1 wt %
colorants.
[0508] The compositions types i) to xi) may optionally comprise
further auxiliaries, such as 0.1-1 wt % bactericides, 5-15 wt %
anti-freezing agents, 0.1-1 wt % anti-foaming agents, and 0.1-1 wt
% colorants.
[0509] The agrochemical compositions generally are characterized in
that they contain an effective quantity of the active components as
defined above. Generally, they contain between 0.01 and 95%,
preferably between 0.1 and 90%, and in particular between 0.5 and
75%, by weight of active components, in particular active
substances.
[0510] According to one embodiment, the compositions contain
biopesticides from groups L1), L3) and L5) in an amount from
1.times.10.sup.5 to 1.times.10.sup.12 CFU, preferably from
1.times.10.sup.7 CFU to 1.times.10.sup.12 CFU, more preferably from
1.times.10.sup.9 CFU to 1.times.10.sup.12 CFU per gram total weight
of the composition.
[0511] Solutions for seed treatment (LS), suspoemulsions (SE),
flowable concentrates (FS), powders for dry treatment (DS),
water-dispersible powders for slurry treatment (WS), water-soluble
powders (SS), emulsions (ES), emulsifiable concentrates (EC) and
gels (GF) are usually employed for the purposes of treatment of
plant propagation materials, particularly seeds.
[0512] Preferred examples of seed treatment formulation types or
soil application for pre-mix compositions are of WS, LS, ES, FS, WG
or CS-type.
[0513] The compositions in question give, after two-to-tenfold
dilution, active components concentrations of from 0.01 to 60% by
weight, preferably from 0.1 to 40%, in the ready-to-use
preparations. Application can be carried out before or during
sowing. Methods for applying or treating compound I and compound II
and compositions thereof, respectively, on to plant propagation
material, especially seeds include dressing, coating, pelleting,
dusting, soaking and in-furrow application methods of the
propagation material. Preferably, compound I and compound II or the
compositions thereof, respectively, are applied on to the plant
propagation material by a method such that germination is not
induced, e.g. by seed dressing, pelleting, coating and dusting.
[0514] Typically, a pre-mix formulation for seed treatment
application comprises 0.5 to 99.9 percent, especially 1 to 95
percent, of the desired ingredients, and 99.5 to 0.1 percent,
especially 99 to 5 percent, of a solid or liquid adjuvant
(including, for example, a solvent such as water), where the
auxiliaries can be a surfactant in an amount of 0 to 50 percent,
especially 0.5 to 40 percent, based on the pre-mix formulation.
Whereas commercial products will preferably be formulated as
concentrates (e.g., pre-mix composition (formulation)), the end
user will normally employ dilute formulations (e.g., tank mix
composition).
[0515] Seed treatment methods for applying or treating inventive
mixtures and compositions thereof to plant propagation material,
especially seeds, are known in the art, and include dressing,
coating, filmcoating, pelleting and soaking application methods of
the propagation material. Such methods are also applicable to the
combinations according to the invention. In a preferred embodiment,
the inventive mixture is applied or treated on to the plant
propagation material by a method such that the germination is not
negatively impacted. Accordingly, examples of suitable methods for
applying (or treating) a plant propagation material, such as a
seed, is seed dressing, seed coating or seed pelleting and
alike.
[0516] It is preferred that the plant propagation material is a
seed, seed piece (i.e. stalk) or seed bulb.
[0517] Although it is believed that the present method can be
applied to a seed in any physiological state, it is preferred that
the seed be in a sufficiently durable state that it incurs no
damage during the treatment process. Typically, the seed would be a
seed that had been harvested from the field; removed from the
plant; and separated from any cob, stalk, outer husk, and
surrounding pulp or other non-seed plant material. The seed would
preferably also be biologically stable to the extent that the
treatment would cause no biological damage to the seed. It is
believed that the treatment can be applied to the seed at any time
between harvest of the seed and sowing of the seed or during the
sowing process (seed directed applications). The seed may also be
primed either before or after the treatment.
[0518] Even distribution of the ingredients in inventive mixtures
and adherence thereof to the seeds is desired during propagation
material treatment. Treatment could vary from a thin film
(dressing) of the formulation containing the combination, for
example, a mixture of active ingredient(s), on a plant propagation
material, such as a seed, where the original size and/or shape are
recognizable to an intermediary state (such as a coating) and then
to a thicker film (such as pelleting with many layers of different
materials (such as carriers, for example, clays; different
formulations, such as of other active ingredients; polymers; and
colourants) where the original shape and/or size of the seed is no
longer recognizable.
[0519] An aspect of the present invention includes application of
the inventive mixtures onto the plant propagation material in a
targeted fashion, including positioning the ingredients in the
combination onto the entire plant propagation material or on only
parts thereof, including on only a single side or a portion of a
single side. One of ordinary skill in the art would understand
these application methods from the description provided in
EP954213B1 and WO06/112700.
[0520] The inventive mixtures can also be used in form of a "pill"
or "pellet" or a suitable substrate and placing, or sowing, the
treated pill, or substrate, next to a plant propagation material.
Such techniques are known in the art, particularly in EP1124414,
WO07/67042, and WO07/67044. Application of the combinations
described herein onto plant propagation material also includes
protecting the plant propagation material treated with the
combination of the present invention by placing one or more
pesticide-containing particles next to a pesticide-treated seed,
wherein the amount of pesticide is such that the pesticide-treated
seed and the pesticide-containing particles together contain an
Effective Dose of the pesticide and the pesticide dose contained in
the pesticide-treated seed is less than or equal to the Maximal
Non-Phytotoxic Dose of the pesticide. Such techniques are known in
the art, particularly in WO2005/120226.
[0521] Application of the combinations onto the seed also includes
controlled release coatings on the seeds, wherein the ingredients
of the combinations are incorporated into materials that release
the ingredients over time. Examples of controlled release seed
treatment technologies are generally known in the art and include
polymer films, waxes, or other seed coatings, wherein the
ingredients may be incorporated into the controlled release
material or applied between layers of materials, or both.
[0522] Seed can be treated by applying thereto the compound s
present in the inventive mixtures in any desired sequence or
simultaneously.
[0523] The seed treatment occurs to an unsown seed, and the term
"unsown seed" is meant to include seed at any period between the
harvest of the seed and the sowing of the seed in the ground for
the purpose of germination and growth of the plant.
[0524] Treatment to an unsown seed is not meant to include those
practices in which the active ingredient is applied to the soil but
would include any application practice that would target the seed
during the planting process.
[0525] Preferably, the treatment occurs before sowing of the seed
so that the sown seed has been pre-treated with the combination. In
particular, seed coating or seed pelleting are preferred in the
treatment of the combinations according to the invention. As a
result of the treatment, the ingredients in each combination are
adhered on to the seed and therefore available for pest
control.
[0526] The treated seeds can be stored, handled, sowed and tilled
in the same manner as any other active ingredient treated seed.
[0527] In particular, the present invention relates to a method for
protection of plant propagation material from pests and/or
improving the health of plants grown from said plant propagation
material, wherein the soil, wherein plant propagation material is
sown, is treated with an effective amount of an inventive
mixture.
[0528] In particular, the present invention relates to a method for
protection of plant propagation material from pests, wherein the
soil, wherein plant propagation material is sown, is treated with
an effective amount of an inventive mixture.
[0529] In particular, the present invention relates to a method for
protection of plant propagation material from harmful fungi,
wherein the soil, wherein plant propagation material is sown, is
treated with an effective amount of an inventive mixture.
[0530] In particular, the present invention relates to a method for
protection of plant propagation material from animal pests
(insects, acarids or nematodes), wherein the soil, wherein plant
propagation material is sown, is treated with an effective amount
of an inventive mixture.
[0531] In one embodiment, the treatment(s) are carried out as
foliar application.
[0532] In another embodiment, the treatment(s) are carried out as
soil application.
[0533] In one embodiment, the treatment(s) are carried out as seed
treatment.
[0534] When employed in plant protection, the total amounts of
active components applied are, depending on the kind of effect
desired, from 0.001 to 10 kg per ha, preferably from 0.005 to 2 kg
per ha, more preferably from 0.05 to 0.9 kg per ha, in particular
from 0.1 to 0.75 kg per ha. In the case of compounds II, the
application rates preferably range from about 1.times.10.sup.6 to
5.times.10.sup.15 (or more) CFU/ha. Preferably, the spore
concentration is about 1.times.10.sup.7 to about 1.times.10.sup.12
CFU/ha. In the case of (entomopathogenic) nematodes as microbial
pesticides (e.g. Steinernema feltiae), the application rates
preferably range inform about 1.times.10.sup.5 to 1.times.10.sup.12
(or more), more preferably from 1.times.10.sup.8 to
1.times.10.sup.11, even more preferably from 5.times.10.sup.8 to
1.times.10.sup.10 individuals (e.g. in the form of eggs, juvenile
or any other live stages, preferably in an infective juvenile
stage) per ha.
[0535] When employed in plant protection by seed treatment, the
amount of the inventive mixtures (based on total weight of active
components) is in the range from 0.01-10 kg, preferably from
0.1-1000 g, more preferably from 1-100 g per 100 kg of plant
propagation material (preferably seeds). In the case of compounds
II, the application rates with respect to plant propagation
material preferably range from about 1.times.10.sup.6 to
1.times.10.sup.12 (or more) CFU/seed. Preferably, the concentration
is about 1.times.10.sup.6 to about 1.times.10.sup.9 CFU/seed. In
the case of compounds II, the application rates with respect to
plant propagation material also preferably range from about
1.times.10.sup.7 to 1.times.10.sup.14 (or more) CFU per 100 kg of
seed, preferably from 1.times.10.sup.9 to about 1.times.10.sup.12
CFU per 100 kg of seed.
[0536] When used in the protection of materials or stored products,
the amount of active components applied depends on the kind of
application area and on the desired effect. Amounts customarily
applied in the protection of materials are 0.001 g to 2 kg,
preferably 0.005 g to 1 kg, of active components per cubic meter of
treated material.
[0537] Various types of oils, wetters, adjuvants, fertilizer, or
micronutrients, and further pesticides (e.g. herbicides,
insecticides, fungicides, growth regulators, safeners,
biopesticides) may be added to the mictures or the compositions
comprising them as premix or, if appropriate not until immediately
prior to use (tank mix). These agents can be admixed with the
mixtures or compositions according to the invention in a weight
ratio of 1:100 to 100:1, preferably 1:10 to 10:1.
[0538] These further useful active compounds can be fertilizers or
micronutrient donors (such as Mo, Zn and/or Co), especially when
applied to plant propagation materials.
[0539] According to one embodiment, a polyether polymethylsiloxane
copolymer may be added to the mixture or composition according to
the invention, preferably in a weight ratio of 1:100 to 100:1, more
preferably in a weight ratio of 1:10 to 10:1, in particular in a
weight ratio of 1:5 to 5:1 based on the total weight of the
compound I and compound II.
[0540] According to a further embodiment, a mineral oil or a
vegetable oil may be added to the mixture or composition according
to the invention, preferably in a weight ratio of 1:100 to 100:1,
more preferably in a weight ratio of 1:10 to 10:1, in particular in
a weight ratio of 1:5 to 5:1 based on the total weight of compound
I and compound II.
[0541] The user applies the mixture or composition according to the
invention usually from a predosage device, a knapsack sprayer, a
spray tank, a spray plane, or an irrigation system. Usually, the
agrochemical composition is made up with water, buffer, and/or
further auxiliaries to the desired application concentration and
the ready-to-use spray liquor or the agrochemical composition
according to the invention is thus obtained. Usually, 20 to 2000
liters, preferably 50 to 400 liters, of the ready-to-use spray
liquor are applied per hectare of agricultural useful area.
[0542] In one embodiment, the at least one compound I and the at
least one compound II are applied simultaneously, either as a
mixture or separately, or subsequently to the soil, the plant or
the plant propagules.
[0543] Moreover, we have found that simultaneous, that is joint or
separate, application of at least one active compound I and at
least one active compound II or the successive application of at
least one active compound I and at least one active compound II
synergistically increase the efficacy for controlling pests or for
improving the health of a plant or for inhibiting nitrification
compared to the application of the individual components alone.
[0544] In one embodiment, compound I and compound II are present in
a synergistically effective amount.
[0545] When applying at least one compound I and at least one
compound II sequentially the time between both applications may
vary e.g. between 2 hours to 7 days. Also a broader range is
possible ranging from 0.25 hour to 30 days, preferably from 0.5
hour to 14 days, particularly from 1 hour to 7 days or from 1.5
hours to 5 days, even more preferred from 2 hours to 1 day.
[0546] In the mixtures and compositions, the compound ratios are
advantageously chosen so as to produce a synergistic effect.
[0547] The term "synergstic effect" is understood to refer in
particular to that defined by Colby's formula (Colby, S. R.,
"Calculating synergistic and antagonistic responses of herbicide
combinations", Weeds, 15, pp. 20-22, 1967).
[0548] The term "synergistic effect" is also understood to refer to
that defined by application of the Tammes method, (Tammes, P. M.
L., "Isoboles, a graphic representation of synergism in
pesticides", Netherl. J. Plant Pathol. 70, 1964).
[0549] According to the invention, the solid material (dry matter)
of the biopesticides (with the exception of oils such as Neem oil,
Tagetes oil, etc.) are considered as active components (e.g. to be
obtained after drying or evaporation of the extraction medium or
the suspension medium in case of liquid formulations of the
microbial pesticides).
[0550] In accordance with the present invention, the weight ratios
and percentages used herein for a biological extract such as
Quillay extract are based on the total weight of the dry content
(solid material) of the respective extract(s).
[0551] The total weight ratios of compositions comprising at least
one microbial pesticide in the form of viable microbial cells
including dormant forms, can be determined using the amount of CFU
of the respective microorganism to calculate the total weight of
the respective active component with the following equation that
1.times.10.sup.10 CFU equals one gram of total weight of the
respective active component. Colony forming unit is measure of
viable microbial cells, in particular fungal and bacterial cells.
In addition, here "CFU" may also be understood as the number of
(juvenile) individual nematodes in case of (entomopathogenic)
nematode biopesticides, such as Steinernema feltiae.
[0552] For mixtures according to the invention comprising compound
I (nitrification inhibitor) and compound II (biopesticide), the
weight ratio of compound I and compound II generally depends from
the properties of the active substances used, usually it is in the
range of from 1:1000 to 1000:1, regularly in the range of from
1:500 to 500:1, preferably in the range of from 1:250 to 250:1,
more preferably in the range of from 1:100 to 100:1, most
preferably in the range of from 1:70 to 70:1, particularly
preferably in the range of from 1:50 to 50:1, particularly more
preferably in the range of from 1:30 to 30:1, particularly most
preferably in the range from 1:20 to 20:1, particularly in the
range of from 1:15 to 15:1, especially preferably in the range of
from 1:10 to 10:1, especially more preferably in the range of from
1:8 to 8:1, especially most preferably in the range of from 1:6.5
to 6.5:1, especially in the range of from 1:5 to 5:1, in particular
preferably in the range of 1:4 to 4:1, in particular more
preferably in the range of from 1:3 to 3:1, in particular most
preferably in the range of from 2.5:1 to 1:2.5, in particular in
the range of from 1:2 to 2:1, for example in the range of from
1:1.5 to 1.5:1. For mixtures according to the invention, the weight
ratio of compound I and compound II generally depends from the
properties of the active substances used, usually it is not more
than 1000:1, regularly not more than 250:1, preferably not more
than 100:1, more preferably not more than 50:1, most preferably not
more than 30:1, particularly preferably not more than 15:1,
particularly more preferably not more than 8:1, particularly most
preferably not more than 4:1, particularly not more than 2:1,
especially preferably not more than 1:1, especially more preferably
not more than 1:2, especially most preferably not more than 1:4,
especially not more than 1:8, in particular preferably not more
than 1:15, in particular more preferably not more than 1:30, in
particular most preferably not more than 1:50, in particular not
more than 1:100, for example preferably not more than 1:250, for
example not more than 1:1000. For mixtures according to the
invention, the weight ratio of compound I and compound II generally
depends from the properties of the active substances used, usually
it is at least 1000:1, regularly at least 250:1, preferably at
least 100:1, more preferably at least 50:1, most preferably at
least 30:1, particularly preferably at least 15:1, particularly
more preferably at least 8:1, particularly most preferably at least
4:1, particularly at least 2:1, especially preferably at least 1:1,
especially more preferably at least 1:2, especially most preferably
at least 1:4, especially at least 1:8, in particular preferably at
least 1:15, in particular more preferably at least 1:30, in
particular most preferably at least 1:50, in particular at least
1:100, for example preferably at least 1:250, for example at least
1:1000.
[0553] In another preferred embodiment, compound I and compound II
are present in a weight ratio of from 250:1 to 1:250, preferably in
a weight ratio of from 100:1 to 1:100, more preferably in a weight
ratio of from 50:1 to 1:50, more preferably in a weight ratio of
from 30:1 to 1:30, most preferably in a weight ratio of from 15:1
to 1:15, particularly in a weight ratio of from 8:1 to 1:8,
particularly preferably in a weight ratio of from 4:1 to 1:4,
particularly more preferably in a weight ratio of from 2:1 to 1:2,
particularly most preferably in a weight ratio of from 1.5:1 to
1:1.5.
[0554] In another preferred embodiment, compound I and compound II
are present in a weight ratio of from 250:1 to 1:250, preferably in
a weight ratio of from 100:1 to 1:100, more preferably in a weight
ratio of from 50:1 to 1:50, more preferably in a weight ratio of
from 30:1 to 1:30, most preferably in a weight ratio of from 15:1
to 1:15, particularly in a weight ratio of from 8:1 to 1:8,
particularly preferably in a weight ratio of from 4:1 to 1:4,
particularly more preferably in a weight ratio of from 2:1 to 1:2,
particularly most preferably in a weight ratio of from 1.5:1 to
1:1.5, wherein the total weight of compound II is based on the
amount of the solid material (dry matter) of compound II.
[0555] In another preferred embodiment, compound I and compound II
are present in a weight ratio of from 250:1 to 1:250, preferably in
a weight ratio of from 100:1 to 1:100, more preferably in a weight
ratio of from 50:1 to 1:50, more preferably in a weight ratio of
from 30:1 to 1:30, most preferably in a weight ratio of from 15:1
to 1:15, particularly in a weight ratio of from 8:1 to 1:8,
particularly preferably in a weight ratio of from 4:1 to 1:4,
particularly more preferably in a weight ratio of from 2:1 to 1:2,
particularly most preferably in a weight ratio of from 1.5:1 to
1:1.5, wherein the total weight of compound II is calculated on the
basis of the amount of CFU of compound II, wherein 1.times.10.sup.9
CFU equals one gram of total weight of compound II.
[0556] In another preferred embodiment, compound I and compound II
are present in a weight ratio of from 1000:1 to 1:1000, preferably
in a weight ratio of from 500:1 to 1:500, more preferably in a
weight ratio of from 300:1 to 1:300, more preferably in a weight
ratio of from 150:1 to 1:80, most preferably in a weight ratio of
from 100:1 to 1:30, particularly in a weight ratio of from 70:1 to
1:10, particularly preferably in a weight ratio of from 50:1 to
1:1, particularly more preferably in a weight ratio of from 25:1 to
1.5:1, particularly most preferably in a weight ratio of from 15:1
to 2:1, for example in a weight ratio of either from 12:1 to 8:1 or
from 5:1 to 2.5:1, wherein the total weight of compound II is
calculated on the basis of the amount of CFU of compound II,
wherein 1.times.10.sup.9 CFU equals one gram of total weight of
compound II.
[0557] In another preferred embodiment, compound I and compound II
are present in a weight ratio of from 100:1 to 1:1000, preferably
in a weight ratio of from 50:1 to 1:500, more preferably in a
weight ratio of from 30:1 to 1:300, more preferably in a weight
ratio of from 15:1 to 1:100, most preferably in a weight ratio of
from 10:1 to 1:70, particularly in a weight ratio of from 7:1 to
1:40, particularly preferably in a weight ratio of from 3:1 to
1:25, particularly more preferably in a weight ratio of from 1:1 to
1:15, particularly most preferably in a weight ratio of from 1:2 to
1:10, for example in a weight ratio of either from 1:4 to 1:7.
[0558] In another preferred embodiment, the mixture or composition
according to the invention contains
a) DMPSA1 and/or DMPSA2, and/or a derivative thereof, and/or a salt
thereof, as compound I, and b) Bradyrhizobium japonicum, preferably
Bradyrhizobium japonicum 532c, as compound II, wherein the compound
I and compound II are present in a weight ratio of from 1000:1 to
1:1000, preferably in a weight ratio of from 500:1 to 1:500, more
preferably in a weight ratio of from 300:1 to 1:300, more
preferably in a weight ratio of from 150:1 to 1:80, most preferably
in a weight ratio of from 100:1 to 1:30, particularly in a weight
ratio of from 70:1 to 1:10, particularly preferably in a weight
ratio of from 50:1 to 1:1, particularly more preferably in a weight
ratio of from 25:1 to 1.5:1, particularly most preferably in a
weight ratio of from 15:1 to 2:1, for example in a weight ratio of
either from 12:1 to 8:1 or from 5:1 to 2.5:1, wherein the total
weight of compound II is calculated on the basis of the amount of
CFU of compound II, wherein 1.times.10.sup.9 CFU equals one gram of
total weight of compound II.
[0559] In another preferred embodiment, the mixture or composition
according to the invention contains
a) DMPSA1 and/or DMPSA2, and/or a derivative thereof, and/or a salt
thereof, as compound I (nitrication inhibitor), b) grape seed
extract (L.6.18) as compound II, wherein the compound I and
compound II are present in a weight ratio of from 100:1 to 1:1000,
preferably in a weight ratio of from 50:1 to 1:500, more preferably
in a weight ratio of from 30:1 to 1:300, more preferably in a
weight ratio of from 15:1 to 1:100, most preferably in a weight
ratio of from 10:1 to 1:70, particularly in a weight ratio of from
7:1 to 1:40, particularly preferably in a weight ratio of from 3:1
to 1:25, particularly more preferably in a weight ratio of from 1:1
to 1:15, particularly most preferably in a weight ratio of from 1:2
to 1:10, for example in a weight ratio of either from 1:4 to
1:7.
[0560] According to further embodiments of the binary mixtures and
compositions, the weight ratio of the compound I and the compound
II usually is in the range of from 1000:1 to 1:1, often in the
range of from 100:1 to 1:1, regularly in the range of from 50:1 to
1:1, preferably in the range of from 20:1 to 1:1, more preferably
in the range of from 10:1 to 1:1, even more preferably in the range
of from 4:1 to 1:1 and in particular in the range of from 2:1 to
1:1.
[0561] According to a further embodiments of the binary mixtures
and compositions, the weight ratio of the compound I and the
compound II usually is in the range of from 1:1 to 1:1000, often in
the range of from 1:1 to 1:100, regularly in the range of from 1:1
to 1:50, preferably in the range of from 1:1 to 1:20, more
preferably in the range of from 1:1 to 1:10, even more preferably
in the range of from 1:1 to 1:4 and in particular in the range of
from 1:1 to 1:2.
[0562] According to further embodiments of the mixtures and
compositions, the weight ratio of the compound I and the compound
II generally depends from the properties of the active components
used, usually it is in the range of from 1:10,000 to 10,000:1,
regularly in the range of from 1:100 to 10,000:1, preferably in the
range of from 1:100 to 5,000:1, more preferably in the range of
from 1:1 to 1,000:1, even more preferably in the range of from 1:1
to 500:1 and in particular in the range of from 10:1 to 300:1.
[0563] According to further embodiments of the mixtures and
compositions, the weight ratio of the compound I and the compound
II usually is in the range of from 20,000:1 to 1:10, often in the
range of from 10,000:1 to 1:1, regularly in the range of from
5,000:1 to 5:1, preferably in the range of from 5,000:1 to 10:1,
more preferably in the range of from 2,000:1 to 30:1, even more
preferably in the range of from 2,000:1 to 100:1 and in particular
in the range of from 1,000:1 to 100:1.
[0564] According to further embodiments of the mixtures and
compositions, the weight ratio of the compound I and the compound
II usually is in the range of from 1:20,000 to 10:1, often in the
range of from 1:10,000 to 1:1, regularly in the range of from
1:5,000 to 1:5, preferably in the range of from 1:5,000 to 1:10,
more preferably in the range of from 1:2,000 to 1:30, even more
preferably in the range of from 1:2,000 to 1:100 and in particular
in the range of from 1:1,000 to 1 100.
[0565] According to further embodiments of the mixtures and
compositions, the weight ratio of the compound I and the compound
II usually is in the range of from 500:1 to 1:500, often in the
range of from 250:1 to 1:250, regularly in the range of from 100:1
to 1:100, preferably in the range of from 50:1 to 1:30, more
preferably in the range of from 25:1 to 1:10, even more preferably
in the range of from 18:1 to 1:5, particularly preferably in the
range of 12:1 to 1:1 and in particular in the range of from 8:1 to
2:1.
[0566] In the ternary mixtures, i.e. compositions according to the
invention comprising the compound I and compound II and a compound
III, the weight ratio of compound I and compound II depends from
the properties of the active substances used, usually it is in the
range of from 1:100 to 100:1, regularly in the range of from 1:50
to 50:1, preferably in the range of from 1:20 to 20:1, more
preferably in the range of from 1:10 to 10:1 and in particular in
the range of from 1:4 to 4:1, and the weight ratio of compound I
and compound III usually it is in the range of from 1:100 to 100:1,
regularly in the range of from 1:50 to 50:1, preferably in the
range of from 1:20 to 20:1, more preferably in the range of from
1:10 to 10:1 and in particular in the range of from 1:4 to 4:1.
[0567] Any further active compounds are, if desired, added in a
ratio of from 20:1 to 1:20 to the compound I.
[0568] These ratios are also suitable for inventive mixtures
applied by seed treatment.
[0569] In further specific embodiments
References