U.S. patent application number 16/477047 was filed with the patent office on 2020-05-07 for composition for enhancing protein strength.
This patent application is currently assigned to LG Household & Health Care Ltd.. The applicant listed for this patent is LG Household & Health Care Ltd.. Invention is credited to Won Kyung Choi, Dong Wan Kim, Jeong Rae Lee, Sang Min Lee, Seong Kil Son, Ji Hee Yoo.
Application Number | 20200138688 16/477047 |
Document ID | / |
Family ID | 63058491 |
Filed Date | 2020-05-07 |
United States Patent
Application |
20200138688 |
Kind Code |
A1 |
Son; Seong Kil ; et
al. |
May 7, 2020 |
Composition For Enhancing Protein Strength
Abstract
A composition for enhancing protein strength according to the
present invention contains an aminosilane compound capable of
covalent binding with a protein of hair, scalp, skin, nails,
leather, or textile, so that the protein and the amino silane
compound form a covalent bond, and thus the composition can improve
the protein strength enhancement effect and maximize the
semi-permanent protein strength enhancement effect.
Inventors: |
Son; Seong Kil; (Daejeon,
KR) ; Choi; Won Kyung; (Daejeon, KR) ; Kim;
Dong Wan; (Daejeon, KR) ; Yoo; Ji Hee;
(Daejeon, KR) ; Lee; Jeong Rae; (Daejeon, KR)
; Lee; Sang Min; (Daejeon, KR) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
LG Household & Health Care Ltd. |
Seoul |
|
KR |
|
|
Assignee: |
LG Household & Health Care
Ltd.
Seoul
KR
|
Family ID: |
63058491 |
Appl. No.: |
16/477047 |
Filed: |
December 12, 2017 |
PCT Filed: |
December 12, 2017 |
PCT NO: |
PCT/KR2017/014555 |
371 Date: |
July 10, 2019 |
Current U.S.
Class: |
1/1 |
Current CPC
Class: |
A61K 8/40 20130101; A61K
8/86 20130101; A61Q 5/00 20130101; A61K 8/585 20130101; A61Q 19/00
20130101; A61K 8/66 20130101; A61K 8/55 20130101; A61K 8/8129
20130101; A61Q 19/10 20130101; A61Q 5/12 20130101; A61K 8/8147
20130101; A61K 8/8176 20130101; A61K 8/64 20130101; A61Q 5/02
20130101; A61K 8/4926 20130101 |
International
Class: |
A61K 8/58 20060101
A61K008/58; A61K 8/55 20060101 A61K008/55; A61K 8/66 20060101
A61K008/66; A61Q 5/00 20060101 A61Q005/00; A61Q 19/00 20060101
A61Q019/00 |
Foreign Application Data
Date |
Code |
Application Number |
Jan 11, 2017 |
KR |
10-2017-0004038 |
Nov 29, 2017 |
KR |
10-2017-0161920 |
Claims
1. A composition for enhancing protein strength, comprising: an
aminosilane compound; and a reaction mediator.
2. The composition according to claim 1, wherein the aminosilane
compound is selected from the group consisting of the compounds
represented by Formulas 1 to 3 below: ##STR00006## wherein in
Formulas 1 to 3, R.sub.1 is each independently hydrogen; or a
linear, branched or cyclic hydrocarbon having 1 to 500 carbon atoms
or a benzene ring hydrocarbon, which includes one or more double
bonds in a part of the molecule, or is substituted with one or more
atoms selected from the group consisting of O, N, S, P and Si or
substituted in an anionic, cationic or amphoteric form, or includes
a structure to which a metal ion is bonded in a salt form; and
R.sub.2 is each independently a linear, branched or cyclic
hydrocarbon having 1 to 500 carbon atoms or a benzene ring
hydrocarbon, which includes one or more double bonds in a part of
the molecule, or is substituted with one or more atoms selected
from the group consisting of O, N, S, P and Si or substituted in an
anionic, cationic or amphoteric form, or includes a structure to
which a metal ion is bonded in a salt form and in which at least
one primary or secondary amine is included at an end of the
molecular structure.
3. The composition according to claim 1, wherein the aminosilane
compound is one or more selected from the group consisting of
3-aminopropyltriethoxysilane, bis[(3-triethoxysilyl)propyl]amine,
3-aminopropyltrimethoxysilane, 4-aminobutyltriethoxysilane,
bis[(3-trimethoxysilyl)propyl]amine,
3-aminopropylmethyldiethoxysilane,
3-aminopropyldimethylethoxysilane,
3-aminopropylmethyldimethoxysilane,
aminoethylaminopropyltrimethoxysilane,
aminoethylaminopropyltriethoxysilane,
aminoethylaminopropylmethyldimethoxysilane,
diethylenetriaminopropylmethyldimethoxysilane,
piperazinylpropylmethyldimethoxysilane,
(n-phenylamino)methyltrimethoxysilane,
(n-phenylamino)methyltriethoxysilane,
3-(n-phenylamino)propyltrimethoxysilane,
n-(n-butyl)-3-aminopropyltrimethoxysilane,
4-aminobutyltriethoxysilane, m-aminophenyltrimethoxysilane,
p-aminophenyltrimethoxysilane, aminophenyltrimethoxysilane,
m-aminophenyltriethoxysilane, p-aminophenyltriethoxysilane,
aminophenyltriethoxysilane,
3-aminopropyltris(methoxyethoxy-ethoxy)silane,
11-aminoundecyltriethoxysilane,
3-(m-aminophenoxy(propyltrimethoxy-silane), aminopropylsilanetriol,
3-aminopropylmethyldiethoxysilane,
3-aminopropyldiisopropylethoxy-silane,
3-aminopropyldimethylethoxysilane,
n-(2-aminoethyl)-3-aminopropyltri-methoxysilane,
n-(2-aminoethyl)-3-aminopropyltri-ethoxysilane,
n-(6-aminohexyl)aminomethyl-triethoxysilane,
n-(6-aminohexyl)aminopropyl-trimethoxysilane,
n-(2-aminoethyl)-11-aminoundecyl-trimethoxysilane,
(aminoethylaminomethyl)phenethyl-trimethoxysilane,
n-3-[(amino(polypropylenoxy)]amino-propyltrimethoxysilane,
n-(2-aminoethyl)-3-aminopropyl-silanetriol,
n-(2-aminoethyl)-3-aminopropylmethyl-dimethoxysilane,
n-(2-aminoethyl)-3-aminoisobutyl-methyldimethoxysilane,
(aminoethylamino)-3-isobutyldi-methylmethoxysilane,
(3-trimethoxysilylpropyl)diethylene-triamine,
n-butylaminopropyltrimethoxy-silane,
n-ethylaminoisobutyltrimethoxy-silane,
n-methylaminopropyltrimethoxy-silane,
n-phenylaminopropyltrimethoxy-silane,
3-(n-allylamino)propyltrimethoxy-silane,
(cyclohexylaminomethyl)tri-ethoxysilane,
n-cyclohexylaminopropyltrimeth-oxysilane,
n-ethylaminoisobutylmethyl-diethoxysilane,
(phenylaminomethyl)methyl-dimethoxysilane,
n-phenylaminomethyltriethoxysilane,
n-methylaminopropylmethyl-dimethoxysilane,
3-(n-styrylmethyl-2-aminoethylamino)-propyltrimethoxysilane
hydrochloride, n-(trimethoxysilylpropyl)isothio-uronium chloride,
bis[(3-trimethoxysilyl)propyl]-ethylenediamine,
bis[(3-trimethoxysilyl)propyl]-ethylenediamine,
bis[3-(triethoxysilyl)propyl]urea, bis(trimethoxysilylpropyl)urea,
bis(methyldiethoxysilylpropyl)amine, ureidopropyltriethoxysilane,
acetamidopropyltrimethoxysilane,
n-[5-(trimethoxysilyl)-2-aza-1-oxo-pentyl]caprolactam and
ureidopropyltrimethoxysilane.
4. The composition according to claim 1, wherein the reaction
mediator is one or more selected from the group consisting of a
carbodiimide-based compound, a dihydroxyquinoline-based compound,
an aminium-based compound, a phosphonium-based compound and an
enzyme.
5. The composition according to claim 4, wherein the
carbodiimidie-based compound is a compound having at least one
methane diimine (--N.dbd.C.dbd.N--) in the molecule.
6. The composition according to claim 4, wherein the
carbodiimidie-based compound is a compound represented by Formula 4
below: ##STR00007## wherein in Formula 4, A is a monomer which has
one or more structures selected from the group consisting of
##STR00008## and includes isocyanate (*) groups at both ends of a
repeat unit, wherein R is each independently hydrogen; or a linear,
branched or cyclic hydrocarbon having 1 to 500 carbon atoms or a
benzene ring hydrocarbon, which includes one or more double bonds
in a part of the molecule, or is substituted with one or more atoms
selected from the group consisting of O, N, S, P and Si or
substituted in an anionic, cationic or amphoteric form, or includes
a structure to which a metal ion is bonded in a salt form; and m is
an integer of 1 to 100.
7. The composition according to claim 4, wherein the
dihydroxyquinoline-based compound is a compound represented by
Formula 5 below: ##STR00009## Wherein in Formula 5, R.sub.1 is one
selected from the group consisting of aqueous non-ionic polymers;
bead- and resin-type polymer resins; and silica beads, and R.sub.2
and R.sub.3 are each independently a linear or branched saturated
alkyl group having 1 to 10 carbon atoms; or an unsaturated alkyl
group.
8. The composition according to claim 7, wherein the aqueous
non-ionic polymer is one or more polymers selected from the group
consisting of polyethylene glycol (PEG), polyvinyl alcohol (PVA),
polyethylene oxide (PEO), polyacrylonitrile (PAN),
polyvinylpyrrolidone (PVP), polyisopropylacrylamide (PNIPPAm), a
cellulose derivative, a starch derivative, dextran and guar gum,
and has a molecular weight of less than 20,000 Da.
9. The composition according to claim 7, wherein the bead- and
resin-type polymer resin is a polymer prepared by polymerizing one
or more monomers selected from the group consisting of styrene,
ethylene, butadiene, acrylonitrile, methylstyrene, terephthalate,
ethylene chloride, ketone ether, imide ether, sulfone ether,
phthalamide, phenylene ether, phenylene oxide, phenylsulfide,
sulfone, urethane, vinylidene fluoride and tetrafluoroethylene, and
has a molecular weight of less than 20,000 Da.
10. The composition according to claim 7, wherein the silica bead
has a diameter of 100 nm to 1 mm.
11. The composition according to claim 4, wherein the aminium-based
compound is one or more selected from the group consisting of
N-[(1H-benzotriazol-1-yl)(dimethylamino)methylene]-N-methylmethanaminium
hexafluorophosphate N-oxide,
N-[(1H-benzotriazol-1-yl)(dimethylamino)methylene]-N-methylmethanaminium
hexafluoroborate, 2-(3,4-(N-[(1H-benzotriazol-1-yl)
(dimethylamino)methylene]-N-methylmethanaminium hexafluorophosphate
N-oxide,
2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-1,1,3,3,-tetrameth-
yl uronium tetrafluoroborate,
O-(3,4,-dihydro-4-oxo-5-azabenzo-1,2,3-triazin-3-yl)-1,1,3,3,-tetramethyl-
uronium hexafluoroborate,
O-(3,4,-dihydro-4-oxo-5-azabenzo-1,2,3-triazin-3-yl)-1,1,3,3,-tetramethyl-
uronium hexafluorophosphate,
2-(2-oxo-1(2H)-pyridyl-1,1,3,3,-tetramethyluronium
tetrafluoroborate,
2-(2-oxo-1(2H)-pyridyl-1,1,3,3-tetramethyluronium
tetrafluorophosphate, 2-succinimido-1,1,3,3-tetramethyluronium
tetrafluoroborate), 2-succinimido-1,1,3,3-tetramethyluronium
tetrafluorophosphate,
N,N,N',N'-bis(tetramethylene-O-pentafluorophenyluronium
tetrafluoroborate,
N,N,N',N'-bis(tetramethylene-O-pentafluorophenyluronium
hexafluorophosphate, N-[6-trifluoromethyl(1H-benzotriazol-1-yl)
(dimethylamino)methylene]-N-methyl methanaminium tetrafluoroborate
N-oxide,
N-[6-trifluoromethyl(1H-benzotriazol-1-yl)(dimethylamino)methyle-
ne]-N-methylmethanaminium hexafluorophosphate N-oxide,
N-[(dimethylamino)-1H-1,2,3-triazolo[4,5,b]pyridin-1-yl]methylene]-N-meth-
ylmethanaminium hexafluorophosphate N-oxide,
N-[(dimethylamino)-1H-1,2,3-triazolo
[4,5-b]pyridin-1-ylmethylene]-N-methyl methanaminium
tetrafluoroborate N-oxide,
N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridin-1-ylmethylene-
]-N-methylmethanaminium hexafluorophosphate N-sulfide,
S-(1-oxido-1-pyridinyl)-1,1,3,3-tetramethylthiouronium
hexafluorophosphate,
O-[cyano(ethoxycarbonyl)methyleneamino]-N,N,N',N'-tetramethyluronium
tetrafluoroborate, O-[cyano(ethoxycarbonyl) methylene
amino]-N,N,N',N'-tetramethyluronium hexafluorophosphate,
O-[(dicyano methylidene)-amino]-1,1,3,3-tetramethyluronium
hexafluorophosphate,
O-[(dimethoxycarbonylmethylidene)-amino]-1,1,3,3-tetramethyluronium
hexafluorophosphate, N-[(cyano(pyridin-2-yl)methylene aminooxy)
(dimethylamino)methylene]-N-methylmethanaminium
hexafluorophosphate,
2-(5-norbornene-2,3-dicarboximido)-1,1,3,3-tetramethyluronium
tetrafluoroborate, 2-phthalimido-1,1,3,3-tetramethyluronium
tetrafluoroborate, bis(tetra methylene)chloroformamidinium
hexafluorophosphate,
(1H-benzotriazol-1-yl)(1-pyrollidinylmethylene) pyrrolidinium
hexafluorophosphate N-oxide, 1-(1-pyrrolidinyl-1H-1,2,3-triazolo
[4,5-b]pyridin-1-ylmethylene) pyrrolidinium hexafluorophosphate
N-oxide, O-(3,4-dihydro-4-oxo-1,2,3-benzo
triazin-3-yl)-1,1,3,3-bis(tetramethylene)uranium
hexafluorophosphate,
O-(3,4-dihydro-4-oxo-5-azabenzo-1,2,3-triazin-3-yl)-1,1,3,3-bis(tetrameth-
ylene) uranium hexafluorophosphate, N,N,N',N'-bis(tetra
methylene)-O-pentafluoro phenyluronium hexafluorphosphate,
N,N,N',N'-bis(tetramethylene)-S-pentafluorothiophenyluronium
hexafluorphosphate,
1-(1-pyrrolidinyl-1H-1,2,3-triazolo[4,5-b]pyridin-1-ylmethylene)
pyrrolidinium hexafluorophosphate N-sulfide,
N,N,N',N'-bis(tetramethylene)-O-2-nitrophenyluronium
hexafluorophosphate,
N,N,N',N'-bis(tetramethylene)-O-pentafluorophenyluronium
hexafluorohosphate,
O-(benzotriazol-1-yl)-1,1,3,3-bis(pentamethylene)
hexafluorophosphate,
O-(7-azabenzotriazol-1-yl)-1,1,3,3-bis(pentamethylene)-uronium
hexafluorophosphate,
2-[2-oxo-1(2H)-pyridyl]-1,1,3,3-bis(pentamethylene) uronium
tetrafluoroborate, 2-chloro-1,3-dimethylimidazolidinium
hexafluorophosphate,
O-(benzotriazol-1-yl)-1,3-dimethyl-1,3-dimethylene uronium
hexafluorophosphate,
O-(7-azabenzotriazol-1-yl)-1,3-dimethyl-1,3-dimethyleneuronium
hexafluorophosphate, 2-chloro-1,3-dimethylpyrimidinium
hexafluorophosphate,
O-(benzotriazol-1-yl)-1,3-dimethyl-1,3-trimethyleneuronium
hexafluorophosphate,
O-(7-azabenzotriazol-1-yl)-1,3-dimethyl-1,3-trimethyleneuronium
hexafluorophosphate, (7-benzotriazol-yl)-1,1,3-tri
methyl-1-hexafluorophosphate,
(7-azabenzotriazol-yl)-1,1,3-trimethyl-1-phenyluronium
hexafluorophosphate,
O-(1H-benzotriazol-1-yl)-1,1-dimethyl-3,3-tetramethylene uranium
hexafluorophosphate,
O-(1H-1,2,3-triazolo[4,5-b[pyridin-yl)-1,1-dimethyl-3,3-tetramethyleneuro-
nium hexafluorophosphate,
O-(1H-benzotriazol-1-yl)-1,1-dimethyl-3,3-pentamethylene uranium
hexafluorophosphate,
6-chloro-1((dimethylamino)(morpholino)methylene)-1H-benzo
triazolium hexafluorophosphate-3oxide,
3-((dimethylamino)-(morpholino)methylene)-1H-[1,2,3]triazolo[4,5-b]pyridi-
nium hexafluorophosphate,
6-trifluoromethyl-1-((dimethylamino)-(morpholino)methylene)-1H-benzotriaz-
oliumhexafluorophosphate-3-oxide, 1-((dimethylamino)-(morpholino))
oxypentafluorophenylmetheniminium hexafluorophosphate,
1-[(1-(cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino
morpholinomethylene)]methanaminium hexafluorophosphate,
1-[(1-(dicyanomethyleneaminooxy) dimethylamino
morpholinomethylene)]methanaminium hexafluorophosphate,
1-[(1,3-diethoxy-1,3-dioxopropan-2-ylideneaminooxy)
dimethylaminomorpholinomethylene)]methanaminium
hexafluorophosphate, N-[(cyano(pyridin-2-yl)methyleneaminooxy)
(dimethylamino)methylene]-N-morpholinomethanaminiumhexafluorophosphate,
1-[(1-(cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylaminopyrrolodino
methylene)]methanaminium hexafluorophosphate,
1-((dicyanomethyleneaminooxy) morpholinomethylene)pyrrolidinium
hexafluorophosphate,
1-[(1,3-diethoxy-1,3-dioxopropan-2-yldeneaminooxy)-dimethylamino-pyrrolod-
inomethylene]]methanaminium hexafluorophosphate,
1-[(1-(cyano-2-ethoxy-2-oxoethylidene
aminooxy)-dimethylamino-pyrrolodinomethylene)]methanaminium
hexafluororphosphate,
1-((1-cyano-2-ethoxy-2-oxoethylideneaminooxy)(morpholino)
methylene)pyrrolidinium hexafluorophosphate,
benzotriazol-1-yloxy-N,N-dimethyl-methanaminium
hexachloroantimonate,
5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl-2H-pyrrolium
hexachloroantimonate,
5-(7-azabenzotriazol-1-yloxy)-3,4-dihydro-1-methyl-2H-pyrrolium
hexachloroantimonate, 1-(1H-benzotriaol-1-yloxy)phenyl-methylene
pyrrolidinium hexachloroantimonate,
5-(pentafluorophenyloxy)-3,4-dihydro-1-methyl-2H-pyrrolium
hexachloroantimonate,
5-(succinimidyloxy)-3,4-dihydro-1-methyl-2H-pyrrolium
hexachloroantimonate,
5-(3',4'-dihydro-4'-oxo-1',2',3'-benzotriazin-3'-yloxy)-3,4-diydro-1-meth-
yl-2H-pyrrolium hexachloroantimonate) and a derivative thereof.
12. The composition according to claim 4, wherein the
phosphonium-based compound is a compound having one or more
phosphonium salts in the molecule.
13. The composition according to claim 4, wherein the
phosphonium-based compound is one or more selected from the group
consisting of benzotriazol-1-yloxytris (dimethylamino) phosphonium
hexafluorophosphate, bromotris (dimethylamino) phosphonium
hexafluorophosphate, chlorotri (pyrrolidino) phosphonium
hexafluorophosphate, bromotri (pyrrolidino) phosphonium
hexafluorophosphate, chloro-tris(dimethylamino) phosphonium
hexafluorophosphate, benzotriazol-1-yloxytri (pyrrolidino)
phosphonium hexafluorophosphate,
[(7-azabenzotriazol-1-yl)oxy]tris-(dimethylamino) phosphonium
hexafluorophosphate,
[(7-azabenzotriazol-1-yl)oxy]tris-(pyrrolidino) phosphonium
hexaflurophosphate,
O-[(cyano-(ethoxycarbonyl)methyliden)-amino]-yloxytripyrrolidino
phosphonium hexafluorophosphate, .left
brkt-bot.(6-nitrobenzotriazol-yl)oxy.right
brkt-bot.tris-(pyrrolidino) phosphonium hexafluorophosphate,
[(6-trifluoromethyl)benzotriazol-1-yl]oxy-tris(pyrrolidino)phosphonium
hexafluorophosphate,
[4-nitro-6-(trifluoromethyl)benzotriazol-1-yl]oxy]tris(pyrrolidino)
phosphonium hexafluorophosphate,
(6-chloro-benzotriazol-1-yloxy)tris (pyrrolidino)-phosphonium
hexafluorophosphate, N',N',N',N'-bis(tetramethylene)-O-pentafluoro
phenyluronium hexafluorophosphate, (pyridyl-2-thio)tris
(pyrrolidino)-phosphonium hexafluorophosphate,
[(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)oxy]tris-(pyrrolidino)phospho-
nium hexafluorophosphate,
[(3,4-dihydro-4-oxo-5-azabenzo-1,2,3-triazin-3-yl]tris-(pyrrolidino)
phosphonium hexafluorophosphate and a derivative thereof.
14. The composition according to claim 4, wherein the enzyme is
transglutaminase, sortase A, tyrosinase, laccase/peroxidase or
lysyl oxidase/amine oxidase.
15. The composition according to claim 1, which is for enhancing
the strength of a hair, scalp, skin, finger/toe nail, leather or
fiber protein.
16. The composition according to claim 1, wherein the aminosilane
compound is contained at 0.000001 to 30 parts by weight with
respect to 100 parts by weight of the total composition.
17. The composition according to claim 1, wherein the reaction
mediator is contained at 0.001 to 20 parts by weight with respect
to 100 parts by weight of the total composition.
18. A care product comprising the composition for enhancing protein
strength of claim 1.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a national phase entry under 35 U.S.C.
.sctn. 371 of International Application No. PCT/KR2017/014555,
filed Dec. 12, 2017, which claims priority to Korean Patent
Application No. 10-2017-0004038, filed Jan. 11, 2017 and Korean
Patent Application No. 10-2017-0161920, filed Nov. 29, 2017.
TECHNICAL FIELD
[0002] The present invention relates to a composition for enhancing
protein strength of hair, skin, finger/toe nails, leather or
fiber.
BACKGROUND ART
[0003] The skin is tissue covering the surface of a body,
consisting of the epidermis, the dermis and a subcutaneous fat
layer, and skin appendages include a sweat gland, a sebaceous
gland, hair, and hand/toe nails. The epidermis constituting the
outermost part of the skin is derived from the ectoderm, and
largely consists of an inner part formed of living cells called the
malpighian layer, and an outer part, the stratum corneum, formed of
anucleate, flat, dry and dead cells. The thicknesses of the skin
are about 0.03 mm at a face part, about 0.16 to 0.8 mm at the palms
and soles of feet, and about 0.1 mm at an eyelid, which is the
thinnest part. The epidermis is generally the stratified squamous
cornified epithelium, mainly consisting of keratinocytes, and also
including melanocytes, Langerhans cells and Merkel cells.
[0004] The keratinocyte is the main component of the epidermis,
which is divided into four layers such as the cornified layer (the
outermost layer), the granular layer, the spinous layer and the
basal layer, and there is a translucent layer between the cornified
layer and the granular layer at the soles of palms and feet.
[0005] Millions of new cells are formed every day in the epidermis,
and continue to be shed from the outermost part of the epidermis
without staying in one place. Here, these cells gradually turn into
rigid keratin when being shed from the cells. The cells of the
epidermis are first made in the basal layer, and their shapes and
functions are also changed while gradually rising toward the
surface.
[0006] The epidermis is gradually transformed into the basal layer,
the spinous layer, the granular layer and the cornified layer as
keratinized, and all of these cells are cells made during
keratogenesis, and thus called keratinocytes.
[0007] A differentiation process in the keratinocytes is performed
through four steps: 1) division of basal cells, 2) synthesis and
alignment in spinous cells, 3) self-degradation in granular cells,
and 4) reconstruction in corneocytes, and in the final step of
differentiation, the cornified layer is formed. This process is
called keratinization.
[0008] The life span of keratinocytes is about 28 days, and
although slightly varying from site to site, millions of
keratinocytes are detached every day, and millions of new cells are
generated from the underlying layer. On the skin surface of the
human body, aging keratinocytes are continuously being shed, and in
aged skin, it takes more time for the detachment of the cornified
layer, resulting in thickening of the cornified layer. Therefore,
the functional degradation of keratinocytes leads to generation of
more dead cells, and causes fine lines and skin roughness.
[0009] The cornified layer is a part forming keratin, which is the
outermost, rigid, dry and thin layer, and consisting of 20 to 25
layers. The cornified layer is the name given due to the fact that
a protein consists of keratin made by changing a protein to be
rigid. As it is close to the skin surface, the cornified layer has
a flat and long shape. The main components of the cornified layer
include the keratin protein (58%), a lipid (11%), a natural
moisturizing factor (NMF, 38%). The thickness of the cornified
layer varies depending on a body part, and the palms or soles have
very thick cornified layers and thus they can withstand physical
impact, friction or trauma which is received in daily life.
Although the cornified layer consists of anucleate, dead cells and
keratin protein, it is most important in terms of skin protection.
The cornified layer plays an important role in preventing external
bacteria or foreign toxic substances from entering the body, and
dehydration of the body. The main component of the cornified layer
is the keratin protein (58%), consisting of amino acids such as
glycine, alanine, valine, leucine, isoleucine, threonine, serine,
cysteine, cystine, methionine, aspartic acid, asparagine, glutamic
acid, diiodotyrosine, lysine, arginine, histidine, phenylalanine,
tyrosine, tryptophan, proline and oxyproline, and particularly, the
keratin constituted in the cornified layer includes about 6.4 to
8.1% of aspartic acid, about 9.1 to 15.4% of glutamic acid, and
about 3.1 to 6.9% of lysine.
[0010] Generally, hair is a keratinized structure formed by
embryological depression of the epithelium, and corresponds to one
of the skin appendages including a sweat gland and a sebaceous
gland. Hair refers to the coat covering the outside of the human
body, including the hair on the head, soft hair, mustaches or
beards, the hair under the arms, pubic hair, etc., and in some
cases, only refers to hair on the scalp.
[0011] Hair consists of the keratin protein which is the same as
the main component of the cornified layer, and keratin is largely
classified into two according to origin. The keratin constituting
the cornified layer is called soft keratin, and keratin
constituting hair and finger nails is called hard keratin. The
keratin is divided due to the difference in content of cysteine,
which is one of the amino acids, and the hard keratin has a high
cysteine content, and the soft keratin has a low cysteine content.
Therefore, the hard keratin is highly resistant to an external
stimulus or the penetration of a chemical substance.
[0012] A hair fiber has a thickness of about 50 to 100 .mu.m,
consists of a cuticle and a cortex, and sometimes, further includes
a medulla, present in the middle of the hair fiber. All of these
cells are dead cells, and most of them are filled with the keratin
protein.
[0013] Human hair consists of about 65 to 95% of the keratin
protein, and includes water and lipids (binding and unbinding
types), a pigment, and trace elements. The protein is formed of
mixtures of about 20 to 50 amino acids in a long chain, and each
chain is wound in a helical or coiled form.
[0014] Among the numerous amino acid compositions constituting
human hair, cystine is one of the most important amino acids.
Cystine is composed of two cysteines (thiols), which are present in
different amino acid chains, respectively, and has a disulfide bond
known as a very strong bond forming a bond between two sulfur atoms
in close proximity to each other. In addition to the disulfide
bond, hair includes very abundant peptide bonds. In addition, due
to the presence of many CO--and NH-- groups, there is hydrogen
bonding between neighboring chain molecular groups. However, due to
a high cystine content, which is the very unique part of the cell
structure of human hair, the physical characteristics of hair are
exhibited. A pigment, which is a part related to a hair color, is
melanin, and is mainly present in granule form at the cortex of
human hair.
[0015] Most of the hair consists of a protein, and the other
components include the melanin pigment, lipids, trace elements, and
water. The protein that constitutes most of the amino acid
composition of hair is the keratin protein abundantly containing
cysteine. Hair keratin consists of about 18 types of amino acids,
and compared to the human epithelium, it has a large cysteine
content. In addition, a ratio of basic amino acids, for example,
histidine, lysine and arginine is 1:3:10, which is the unique ratio
of hair keratin. Skin collagen has high glycine, proline and
alanine contents without cysteine. The melanin pigment determining
hair color is contained in the hair at about 3% or less.
[0016] In addition to the protein and the melanin pigment, it has
been known that the hair contains minerals such as copper, zinc,
iron, calcium and magnesium, and trace elements, and other than
these elements, also contains inorganic components such as
phosphorus, silicon, etc.
[0017] In addition to the peptide bonds between amino acids in the
protein, bonds present in the hair include intermolecular forces or
binding strength between molecules of each protein, which maintain
the morphology and shape of hair. Types of bonds largely include
crosslinking bonds such as a cystine bond and a peptide bond, and
non-cros slinking bonds such as an ionic bond, a hydrogen bond and
a hydrophobic interaction. Among these, the cystine bond (disulfide
bond; --CH.sub.2--S--S--CH.sub.2--), uniquely formed in a sulfur
(S)-containing protein, is a side chain bond not shown in other
fibers and a bond characteristically shown in keratin. The cystine
bond imparts strong physiochemical characteristics to the
keratin.
[0018] The keratin protein (58%), which is the main component of
hair, consists of amino acids such as glycine, alanine, valine,
leucine, isoleucine, threonine, serine, cysteine, cystine,
methionine, aspartic acid, asparagine, glutamic acid,
diiodotyrosine, lysine, arginine, histidine, phenylalanine,
tyrosine, tryptophan, proline and oxyproline, and particularly, the
keratin constituting the hair includes about 3.9 to 7.7% of
aspartic acid, about 13.6 to 14.2% of glutamic acid, and about 1.9
to 3.1% of lysine.
[0019] Generally, fibers may be largely divided into natural fibers
and artificial fibers, and among the natural fibers, a fiber
obtained from an animal is referred to as an animal fiber, whose
chemical component is a protein, and thus is also called a
protein-based fiber. The protein-based fibers include a fiber
obtained from the coat of an animal and a fiber obtained from
cocoons, and the fibers obtained from the animal coat may be
divided into wool obtained from the coat of sheep and a hair fiber
obtained from goats, camels, rabbits, horses, cows, or other
animals
[0020] Like the hair, these protein-based fibers consist of amino
acids such as glycine, alanine, valine, leucin, isoleucine,
threonine, serine, cysteine, cystine, methionine, aspartic acid,
asparagine, glutamic acid, diiodotyrosine, lysine, arginine,
histidine, phenylalanine, tyrosine, tryptophan, proline and
oxyproline, and the most generally and widely used wool among the
protein-based fibers is known to have an amino acid composition
similar to the hair.
[0021] These protein-based fibers, hair, skin, finger/toe nails and
leather are types of very rigid proteins under mild conditions such
as water or a neutral solvent, but may be easily damaged by
physical/chemical treatment and environmental stress such as
combing, heat of a dryer, dyeing or a permanent, which commonly
occurs in common life, physical friction in daily life, washing,
sunlight, heat of ironing, adsorption of a pollutant, exposure to
ultraviolet rays, exposure to high and low temperatures, seawater,
or chlorine of a pool. Accordingly, the damaged hair, skin,
finger/toe nails, fibers or leather have pores due to the release
of proteins inside and outside and thus becomes rough, thereby
having problems of decreased softness and elasticity, difficult
handling due to increased friction, lower glossiness and a turbid
color.
[0022] Therefore, to improve the surface characteristics of a
substrate such as hair, skin, fibers or leather, and thus maintain
beautiful and heathy appearance, a treatment agent is used.
Particularly, glossiness, softness and smoothness are important and
representative surface characteristics to be improved.
[0023] Examples of the treatment agents for imparting strength
improvement include hair cosmetic agents, such as a shampoo, a
rinse, a treatment, a wax, a spray, a mousse, a hair lotion, a hair
cream, a pack, a mask, a sheet, etc., cosmetic agents for skin,
such as a skin, a lotion, an essence, a serum, a cream, a gel, a
foundation, a powder, a makeup base, point makeup, a mask, a patch,
etc., fabric care agents such as a fabric softener, a fabric
coloring agent, a detergent, a treatment, a pre/after treatment
agent, a laundry aid, a spot stain remover, a spray, etc. The
treatment agents also include finger/toe nail treatment agents such
as a polisher, a nutrient, an enhancer, etc., and a leather
treatment agent such as a cream, a lotion, an essence, a serum, a
gel, a wax, a spray, a cleanser, a cleaner, a spot stain remover, a
salve-type agent, a polisher, a strip, a sheet, etc.
[0024] In addition, generally, the "cosmetic" is used to clean and
make the body look more beautiful, enhance attractiveness, change
an appearance, or healthily maintain skin or hair by applying,
spraying, or other similar methods onto the body, and defined as
being slightly effective on the human body. Such cosmetics have
various functions for keeping various body parts, such as the skin,
hair, and finger/toe nails, healthy and beautiful, and among these
functions, strength improvement may be one of the main functions of
the cosmetics.
[0025] General raw materials constituting the cosmetic for
improving strength include oil raw materials such as oil, wax,
hydrocarbons, higher fatty acids, higher alcohols, ester oil,
silicone oil, etc., anionic, cationic, amphoteric or non-ionic
surfactants, high-molecular compounds such as moisturizing agents,
thickening agents and coating agents, UV absorption/blocking
agents, antioxidants, sequestering agents, colorants including dyes
and pigments, fragrances, and preservatives.
[0026] Other than these materials, as components for exhibiting
special performance, oil and natural or synthetic fatty acids,
fatty alcohols, alcohols, alkylglycerylethers, esters,
hydrocarbons, silicones, fluorine compounds, polyhydric alcohols,
saccharides, natural or synthetic polymers, wax, vitamins,
hormones, amino acids, peptides, proteins, animal/plant extracts,
mineral extracts, and derivatives thereof may be included.
[0027] However, most of the components for improving strength
included in this composition impart their effect through simple
adsorption, rather than strong covalent bonding. Due to the various
external environments that are experienced in daily lives after the
treatment of the composition, these components are continuously
released, and strength is gradually lowered, and during a cleansing
process, such a phenomenon is further accelerated.
[0028] For example, in Korean Unexamined Patent Application
Publication No. 2014-0096053, a method for glossy makeup through
coating with a keratin substance (particularly, for nails)
including an alkoxy silane and water contained at a predetermined
molar ratio obtained using a specific equation, and a related kit
composition are disclosed. However, due to the limitation in that
only one part of the silane molecule is bound to the protein
surface through dehydration, the composition has a coating ability,
but is not effective in strength improvement which can be obtained
by binding between the silane molecule and the protein at both
ends.
DISCLOSURE
Technical Problem
[0029] The present invention is directed to providing a composition
for enhancing protein strength, which is effective in
semi-permanent improvement in the strength of hair, scalp, skin,
finger/toe nails, leather or fiber.
[0030] The present invention is also directed to providing a care
product including the composition for enhancing protein
strength.
Technical Solution
[0031] To solve the problems of the present invention, the present
invention provides a composition for enhancing protein strength,
which includes an aminosilane compound and a reaction mediator.
[0032] In addition, the present invention provides a care product
including the composition.
Advantageous Effects
[0033] A composition for enhancing protein strength according to
the present invention contains an aminosilane compound which
enables covalent bonding with a protein of hair, scalp, skin,
finger/toe nails, leather or fiber, thereby forming a covalent bond
between the protein and an aminosilane compound, and thus a protein
strength enhancing effect may be improved, and a semi-permanent
protein strength enhancing effect can be maximized
MODES OF THE INVENTION
[0034] The present invention relates to a composition for enhancing
protein strength, which includes an aminosilane compound and a
reaction mediator.
[0035] The "composition for enhancing protein strength" used herein
refers to a composition acting to semi-permanently link proteins
through covalent bonding between an aminosilane compound and
carboxyl groups and amine groups, which are present in large
amounts as a constituent component of a hair, scalp, finger/toe
nail, skin or fiber protein, to enhance protein strength. In
addition, the composition for enhancing protein strength refers to
a composition which makes a protein appear thicker, and has side
effects such as increasing elasticity and thickness.
[0036] The "composition for enhancing protein strength" may include
a composition for enhancing the strength of a hair protein, a
composition for enhancing the strength of a scalp protein, a
composition for enhancing the strength of a skin protein, a
composition for enhancing the strength of a finger/toe nail
protein, a composition for enhancing the strength of a leather
protein and/or a composition for enhancing the strength of a fiber
protein.
[0037] The composition for enhancing protein strength according to
the present invention may allow a reaction between a substrate
consisting of a protein and an aminosilane compound using a
reaction mediator to form a covalent bond between a carboxyl group
of the protein substrate and an amine group of the aminosilane
compound, between an amine group of the protein substrate and a
carboxyl group of the aminosilane compound and/or between the amine
group of the protein substrate and an amine group of the
aminosilane compound, and thus a protein strength enhancement
effect may be semi-permanently maximized
[0038] The "substrate consisting of a protein" includes, for
example, hair, scalp, skin, finger/toe nails, leather and fiber,
but the present invention is not limited thereto.
[0039] The "aminosilane compound" used herein includes mono-, di-
and tri-alkoxyaminosilane compounds represented by the following
Formulas 1 to 3, which have at least one or more amine groups in
the same molecule as well as forming one to three hydroxyl groups
directly binding to silicon (Si) by hydrolysis with water.
##STR00001##
[0040] In Formulas 1 to 3, R.sub.1 is each independently hydrogen;
or a linear, branched or cyclic hydrocarbon having 1 to 500 carbon
atoms or a benzene ring hydrocarbon, which includes one or more
double bonds in a part of the molecule, or is substituted with one
or more atoms selected from the group consisting of O, N, S, P and
Si or substituted in an anionic, cationic or amphoteric form, or
includes a structure to which a metal ion is bonded in a salt form;
and R.sub.2 is each independently a linear, branched or cyclic
hydrocarbon having 1 to 500 carbon atoms or a benzene ring
hydrocarbon, which includes one or more double bonds in a part of
the molecule, or is substituted with one or more atoms selected
from the group consisting of O, N, S, P and Si or substituted in an
anionic, cationic or amphoteric form, or includes a structure to
which a metal ion is bonded in a salt form and in which at least
one primary or secondary amine is included at an end of the
molecular structure.
[0041] The aminosilane compound may be one or more selected from
the group consisting of 3-aminopropyltriethoxysilane,
bis[(3-triethoxysilyl)propyl]amine, 3-aminopropyltrimethoxysilane,
4-aminobutyltriethoxysilane, bis[(3-trimethoxysilyl)propyl]amine,
3-aminopropylmethyldiethoxysilane,
3-aminopropyldimethylethoxysilane,
3-aminopropylmethyldimethoxysilane,
aminoethylaminopropyltrimethoxysilane,
aminoethylaminopropyltriethoxysilane,
aminoethylaminopropylmethyldimethoxysilane,
diethylenetriaminopropylmethyldimethoxysilane,
piperazinylpropylmethyldimethoxysilane,
(n-phenylamino)methyltrimethoxysilane,
(n-phenylamino)methyltriethoxysilane,
3-(n-phenylamino)propyltrimethoxysilane,
n-(n-butyl)-3-aminopropyltrimethoxysilane,
4-aminobutyltriethoxysilane, m-aminophenyltrimethoxysilane,
p-aminophenyltrimethoxysilane, aminophenyltrimethoxysilane,
m-aminophenyltriethoxysilane, p-aminophenyltriethoxysilane,
aminophenyltriethoxysilane,
3-aminopropyltris(methoxyethoxy-ethoxy)silane,
11-aminoundecyltriethoxysilane,
3-(m-aminophenoxy(propyltrimethoxy-silane), aminopropylsilanetriol,
3-aminopropylmethyldiethoxysilane,
3-aminopropyldiisopropylethoxy-silane,
3-aminopropyldimethylethoxysilane,
n-(2-aminoethyl)-3-aminopropyltri-methoxysilane,
n-(2-aminoethyl)-3-aminopropyltri-ethoxysilane,
n-(6-aminohexyl)aminomethyl-triethoxysilane,
n-(6-aminohexyl)aminopropyl-trimethoxysilane,
n-(2-aminoethyl)-11-aminoundecyl-trimethoxysilane,
(aminoethylaminomethyl)phenethyl-trimethoxysilane,
n-3-[(amino(polypropylenoxy)]amino-propyltrimethoxysilane,
n-(2-aminoethyl)-3-aminopropyl-silanetriol,
n-(2-aminoethyl)-3-aminopropylmethyl-dimethoxysilane,
n-(2-aminoethyl)-3-aminoisobutyl-methyldimethoxysilane,
(aminoethylamino)-3-isobutyldi-methylmethoxysilane,
(3-trimethoxysilylpropyl)diethylene-triamine,
n-butylaminopropyltrimethoxy-silane,
n-ethylaminoisobutyltrimethoxy-silane,
methylaminopropyltrimethoxy-silane,
n-phenylaminopropyltrimethoxy-silane,
3-(n-allylamino)propyltrimethoxy-silane,
(cyclohexylaminomethyl)tri-ethoxysilane,
cyclohexylaminopropyltrimeth-oxysilane,
n-ethylaminoisobutylmethyl-diethoxysilane,
(phenylaminomethyl)methyl-dimethoxysilane,
n-phenylaminomethyltriethoxysilane,
n-methylaminopropylmethyl-dimethoxysilane,
3-(n-styrylmethyl-2-aminoethylamino)-propyltrimethoxysilane
hydrochloride, n-(trimethoxysilylpropyl)isothio-uronium chloride,
bis.left brkt-top.(3-trimethoxysilyl)propyl.right
brkt-bot.-ethylenediamine,
bis[(3-trimethoxysilyl)propyl]-ethylenediamine,
bis[3-(triethoxysilyl)propyl]urea, bis(trimethoxysilylpropyl)urea,
bis(methyldiethoxysilylpropyl)amine, ureidopropyltriethoxysilane,
acetamidopropyltrimethoxysilane,
n-[5-(trimethoxysilyl)-2-aza-1-oxo-pentyl]caprolactam and
ureidopropyltrimethoxysilane, but the present invention is not
limited thereto.
[0042] The aminosilane compound may be contained at 0.000001 to 30
parts by weight, 0.001 to 15 parts by weight, 0.01 to 5 parts by
weight with respect to 100 parts by weight of the total
composition. When the content of the aminosilane compound is less
than 0.000001 part by weight, it is difficult to exhibit an effect
of continuously enhancing protein strength, and when the content of
the aminosilane compound is more than 30 parts by weight, an amine
present in the aminosilane compound is contained in the composition
at an excessively large amount, so that there may be a problem with
stability of a formulation.
[0043] In the present invention, the reaction mediator includes one
or more selected from the group consisting of a carbodiimide-based
compound, a dihydroxyquinoline-based compound, an aminium-based
compound, a phosphonium-based compound and an enzyme.
[0044] The carbodiimide-based compound is a compound having at
least one methane diimine (--N.dbd.C.dbd.N--) in the molecule, and
may include a component represented by Formula 4 below:
##STR00002##
[0045] In Formula 4, A is a monomer which has one or more
structures selected from the group consisting of
##STR00003##
and includes isocyanate (*) groups at both ends of a repeat unit,
wherein R is each independently hydrogen; or a linear, branched or
cyclic hydrocarbon having 1 to 500 carbon atoms or a benzene ring
hydrocarbon, which includes one or more double bonds in a part of
the molecule, or is substituted with one or more atoms selected
from the group consisting of O, N, S, P and Si or substituted in an
anionic, cationic or amphoteric form, or includes a structure to
which a metal ion is bonded in a salt form; and m is an integer of
1 to 100.
[0046] The carbodiimide-based compound may be one or more selected
from the group consisting of
1,1'-methylene-bis-(4-isocyanatocyclohexane)-, homopolymer,
polyethylene glycol mono-Me-ether-blocked;
1,1'-methylene-bis-(3-isocyanatocyclohexane)-, homopolymer,
polyethylene glycol mono-Me-ether-blocked;
1,1'-methylene-bis-(4-isocyanatocycloheptane)-, homopolymer,
polyethylene glycol mono-Me-ether-blocked;
1,1'-methylene-bis-(3-isocyanatocycloheptane)-, homopolymer,
polyethylene glycol mono-Me-ether-blocked;
1,1'-methylene-bis-(3-isocyanatocyclopentane)-, homopolymer,
polyethylene glycol mono-Me-ether-blocked; benzene;
1,3-bis(1-isocyanato-1-methylethyl)-, homopolymer, polyethylene
glycol mono-Me-ether-blocked;
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; and
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide HCl, but the present
invention is not limited thereto.
[0047] In one exemplary embodiment, as a reaction mediator, a
carbodiimide-based compound such as benzene;
1,3-bis(1-isocyanato-1-methylethyl)-, homopolymer, polyethylene
glycol mono-Me-ether-blocked; or
1,1'-methylene-bis-(4-isocyanatocyclohexane)-, homopolymer,
polyethylene glycol mono-Me-ether-blocked may be used.
[0048] The dihydroxyquinoline-based compound may be a compound
represented by Formula 5 below:
##STR00004##
[0049] In Formula 5, R.sub.1 may be one selected from the group
consisting of aqueous non-ionic polymers; bead- and resin-type
polymer resins; and silica beads, and R.sub.2 and R.sub.3 may be
each independently a linear or branched saturated alkyl group
having 1 to 10 carbon atoms; or an unsaturated alkyl group.
[0050] The aqueous non-ionic polymer may be one or more polymers
selected from the group consisting of polyethylene glycol (PEG),
polyvinyl alcohol (PVA), polyethylene oxide (PEO),
polyacrylonitrile (PAN), polyvinylpyrrolidone (PVP),
polyisopropylacrylamide (PNIPPAm), a cellulose derivative, a starch
derivative, dextran and guar gum, each having a molecular weight of
less than 20,000 Da, but the present invention is not limited
thereto. When the molecular weight of the aqueous non-ionic polymer
is 20,000 Da or more, a proportion of the dihydroxyquinoline-based
compound inducing covalent bonding is too small, it is difficult to
exhibit a glossy effect.
[0051] The bead- and resin-type polymer resin may be a polymer
prepared by polymerizing one or more monomers selected from the
group consisting of styrene, ethylene, butadiene, acrylonitrile,
methylstyrene, terephthalate, ethylene chloride, ketone ether,
imide ether, sulfone ether, phthalamide, phenylene ether, phenylene
oxide, phenylsulfide, sulfone, urethane, vinylidene fluoride and
tetrafluoroethylene, each having a molecular weight of less than
20,000 Da, but the present invention is not limited thereto.
[0052] When the molecular weight of the bead- and resin-type
polymer resins is more than 20,000 Da, a proportion of the
dihydroxyquinoline-based compound inducing covalent bonding is very
small, it is difficult to exhibit a glossy effect.
[0053] The silica bead may have a diameter of 100 nm to 1 mm, for
example, 100 nm to 100 .mu.m, 1 to 100 .mu.m, or 1 to 70 .mu.m.
When the diameter of the silica bead is smaller than 100 nm, there
may be a problem with safety on the skin surface, and when the
diameter of the silica bead is larger than 1 mm, there are problems
with formulation and stabilization.
[0054] The reaction mediator of the present invention may be an
aminium-based compound, which is a cationic compound having a
--R.sub.3NH.sup.+ structure formed by the hydrogenation of one
amine; or a phosphonium salt (PH.sub.4.sup.+) series compound
having a PH.sub.4.sup.+ structure as a polyatomic cation, but the
present invention is not limited thereto. R.sub.3 is hydrogen; or a
linear, branched or cyclic hydrocarbon having 1 to 500 carbon atoms
or a benzene ring hydrocarbon, which includes one or more double
bonds in a part of the molecule, or is substituted with one or more
atoms selected from the group consisting of O, N, S, P and Si or
substituted in an anionic, cationic or amphoteric form, or includes
a structure to which a metal ion is bonded in a salt form.
[0055] The aminium-based compound may be one or more selected from
the group consisting of
N-[(1H-benzotriazol-1-yl)(dimethylamino)methylene]-N-methylmethanaminium
hexafluorophosphate N-oxide, N-[(1H-benzotriazol-1-yl)
(dimethylamino)methylene]-N-methylmethanaminium hexafluoroborate,
2-(3,4-(N-.left
brkt-top.(1H-benzotriazol-1-yl)(dimethylamino)methylene.right
brkt-bot.-N-methylmethanaminium hexafluorophosphate N-oxide,
2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-1,1,3,3,-tetramethyl
uronium tetrafluoroborate,
O-(3,4,-dihydro-4-oxo-5-azabenzo-1,2,3-triazin-3-yl)-1,1,3,3,-tetramethyl-
uronium hexafluoroborate, O-(3,4,-dihydro-4-oxo
-5-azabenzo-1,2,3-triazin-3-yl)-1,1,3,3 tetramethyluronium
hexafluorophosphate,
2-(2-oxo-1(2H)-pyridyl-1,1,3,3,-tetramethyluronium
tetrafluoroborate,
2-(2-oxo-1(2H)-pyridyl-1,1,3,3-tetramethyluronium
tetrafluorophosphate, 2-succinimido-1,1,3,3-tetramethyluronium
tetrafluoroborate), 2-succinimido-1,1,3,3-tetramethyluronium
tetrafluorophosphate,
N,N,N',N'-bis(tetramethylene-O-pentafluorophenyluronium
tetrafluoroborate,
N,N,N',N'-bis(tetramethylene-O-pentafluorophenyluronium
hexafluorophosphate,
N-[6-trifluoromethyl(1H-benzotriazol-1-yl)(dimethylamino)methylene]-N-met-
hyl methanaminium tetrafluoroborate N-oxide,
N-[6-trifluoromethyl(1H-benzotriazol-1-yl)
(dimethylamino)methylenel-N-methylmethanaminium hexafluorophosphate
N-oxide,
N-[(dimethylamino)-1H-1,2,3-triazolo[4,5,b]pyridin-1-yl]methylen-
e]-N-methylmethanaminium hexafluorophosphate N-oxide,
N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridin-1-ylmethylene]-N-methy-
l methanaminium tetrafluoroborate N-oxide,
N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridin-1-ylmethylene]-N-methy-
lmethanaminium hexafluorophosphate N-sulfide,
S-(1-oxido-1-pyridinyl)-1,1,3,3-tetramethylthiouronium
hexafluorophosphate,
O-[cyano(ethoxycarbonyl)methyleneamino]-N,N,N',N'-tetramethyluronium
tetrafluoroborate, O-[cyano(ethoxycarbonyl) methylene
amino]-N,N,N',N'-tetramethyluronium hexafluorophosphate,
O-[(dicyano methylidene)-amino]-1,1,3,3-tetramethyluronium
hexafluorophosphate,
O-[(dimethoxycarbonylmethylidene)-amino]-1,1,3,3-tetramethyluronium
hexafluorophosphate, N-[(cyano(pyridin-2-yl)methylene aminooxy)
(dimethylamino)methylenel-N-methylmethanaminium
hexafluorophosphate,
2-(5-norbornene-2,3-dicarboximido)-1,1,3,3-tetramethyluronium
tetrafluoroborate, 2-phthalimido-1,1,3,3-tetramethyluronium
tetrafluoroborate, bis(tetra methylene)chloroformamidinium
hexafluorophosphate,
(1H-benzotriazol-1-yl)(1-pyrollidinylmethylene) pyrrolidinium
hexafluorophosphate N-oxide,
1-(1-pyrrolidinyl-1H-1,2,3-triazolo[4,5-b]pyridin-1-ylmethylene)
pyrrolidinium hexafluorophosphate N-oxide,
O-(3,4-dihydro-4-oxo-1,2,3-benzo
triazin-3-yl)-1,1,3,3-bis(tetramethylene)uranium
hexafluorophosphate,
O-(3,4-dihydro-4-oxo-5-azabenzo-1,2,3-triazin-3-yl)-1,1,3,3-bis(tetrameth-
ylene) uranium hexafluorophosphate, N,N,N',N'-bis(tetra
methylene)-O-pentafluoro phenyluronium hexafluorphosphate,
N,N,N',N'-bis(tetramethylene)-S-pentafluorothiophenyluronium
hexafluorphosphate,
1-(1-pyrrolidinyl-1H-1,2,3-triazolo[4,5-b]pyridin-1-ylmethylene)
pyrrolidinium hexafluorophosphate N-sulfide,
N,N,N',N'-bis(tetramethylene)-O-2-nitrophenyluronium
hexafluorophosphate,
N,N,N',N'-bis(tetramethylene)-O-pentafluorophenyluronium
hexafluorohosphate,
O-(benzotriazol-1-yl)-1,1,3,3-bis(pentamethylene)
hexafluorophosphate,
O-(7-azabenzotriazol-1-yl)-1,1,3,3-bis(pentamethylene)-uronium
hexafluorophosphate,
2-[2-oxo-1(2H)-pyridyl]-1,1,3,3-bis(pentamethylene) uronium
tetrafluoroborate, 2-chloro-1,3-dimethylimidazolidinium
hexafluorophosphate,
O-(benzotriazol-1-yl)-1,3-dimethyl-1,3-dimethylene uronium
hexafluorophosphate, O-(7-azabenzotriazol-1-yl)-1
,3-dimethyl-1,3-dimethyleneuronium hexafluorophosphate,
2-chloro-1,3-dimethylpyrimidinium hexafluorophosphate,
O-(benzotriazol-1-yl)-1,3-dimethyl-1,3-trimethyleneuronium
hexafluorophosphate,
O-(7-azabenzotriazol-1-yl)-1,3-dimethyl-1,3-trimethyleneuronium
hexafluorophosphate, (7-benzotriazol-yl)-1,1,3-tri
methyl-1-hexafluorophosphate,
(7-azabenzotriazol-yl)-1,1,3-trimethyl-1-phenyluronium
hexafluorophosphate,
O-(1H-benzotriazol-1-yl)-1,1-dimethyl-3,3-tetramethylene uranium
hexafluorophosphate,
O-(1H-1,2,3-triazolo[4,5-b]pyridin-yl)-1,1-dimethyl-3,3-tetramethyleneuro-
nium hexafluorophosphate,
O-(1H-benzotriazol-1-yl)-1,1-dimethyl-3,3-pentamethylene uranium
hexafluorophosphate,
6-chloro-1((dimethylamino)(morpholino)methylene)-1H-benzo
triazolium hexafluorophosphate-3oxide,
3-((dimethylamino)-(morpholino)methylene)-1H-[1,2,3]triazolo[4,5-b]pyridi-
nium hexafluorophosphate,
6-trifluoromethyl-1-((dimethylamino)-(morpholino)methylene)-1H-benzotriaz-
oliumhexafluorophosphate-3-oxide, 1-((dimethylamino)-(morpholino))
oxypentafluorophenylmetheniminium hexafluorophosphate,
1-[(1-(cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino
morpholinomethylene)]methanaminium hexafluorophosphate,
1-[(1-(dicyanomethyleneaminooxy) dimethylamino
morpholinomethylene)]methanaminium hexafluorophosphate,
1-[(1,3-diethoxy-1,3-dioxopropan-2-ylideneaminooxy)
dimethylaminomorpholinomethylene)]methanaminium
hexafluorophosphate, N-[(cyano(pyridin-2-yl)methyleneaminooxy)
(dimethylamino)methylene]-N-morpholinomethanaminiumhexafluorophosphate,
1-[(1-(cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylaminopyrrolodino
methylene)]methanaminium hexafluorophosphate,
1-((dicyanomethyleneaminooxy) morpholinomethylene)pyrrolidinium
hexafluorophosphate,
1-[(1,3-diethoxy-1,3-dioxopropan-2-yldeneaminooxy)-dimethylamino-pyrrolod-
inomethylene]]methanaminium hexafluorophosphate,
1-[(1-(cyano-2-ethoxy-2-oxoethylidene
aminooxy)-dimethylamino-pyrrolodinomethylene)]methanaminium
hexafluororphosphate,
1-((1-cyano-2-ethoxy-2-oxoethylideneaminooxy)(morpholino)
methylene)pyrrolidinium hexafluorophosphate,
benzotriazol-1-yloxy-N,N-dimethyl-methanaminium
hexachloroantimonate, 5-(1
H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl-2H-pyrrolium
hexachloroantimonate,
5-(7-azabenzotriazol-1-yloxy)-3,4-dihydro-1-methyl-2H-pyrrolium
hexachloroantimonate, 1-(1H-benzotriaol-1-yloxy)phenyl-methylene
pyrrolidinium hexachloroantimonate,
5-(pentafluorophenyloxy)-3,4-dihydro-1-methyl-2H-pyrrolium
hexachloroantimonite,
5-(succinimidyloxy)-3,4-dihydro-1-methyl-2H-pyrrolium
hexachloroantimonate,
5-(3',4'-dihydro-4'-oxo-1',2',3'-benzotriazin-3'-yloxy)-3,4-diydro-1-meth-
yl-2H-pyrrolium hexachloroantimonate) and a derivative thereof, but
the present invention is not limited thereto.
[0056] The phosphonium-based compound may be one or more selected
from the group consisting of
benzotriazol-1-yloxytris(dimethylamino) phosphonium
hexafluorophosphate, bromotris (dimethylamino) phosphonium
hexafluorophosphate, chlorotri (pyrrolidino) phosphonium
hexafluorophosphate, bromotri (pyrrolidino) phosphonium
hexafluorophosphate, chloro-tris(dimethylamino) phosphonium
hexafluorophosphate, benzotriazol-1-yloxytri (pyrrolidino)
phosphonium hexafluorophosphate, .left
brkt-bot.(7-azabenzotriazol-1-yl)oxy.right brkt-bot.tris-(dimethyl
amino) phosphonium hexafluorophosphate,
[(7-azabenzotriazol-1-yl)oxy]tris-(pyrrolidino) phosphonium
hexaflurophosphate,
O-[(cyano-(ethoxycarbonyl)methyliden)-amino]-yloxytripyrrolidino
phosphonium hexafluorophosphate,
[(6-nitrobenzotriazol-yl)oxyltris-(pyrrolidino) phosphonium
hexafluorophosphate,
[(6-trifluoromethyl)benzotriazol-1-yl]oxy-tris(pyrrolidino)phosphonium
hexafluorophosphate,
[4-nitro-6-(trifluoromethyl)benzotriazol-1-yl]oxyl]tris(pyrrolidino)
phosphonium hexafluorophosphate,
(6-chloro-benzotriazol-1-yloxy)tris (pyrrolidino)-phosphonium
hexafluorophosphate, N',N',N',N'-bis(tetramethylene)-O-pentafluoro
phenyluronium hexafluorophosphate, (pyridyl-2-thio)tris
(pyrrolidino)-phosphonium hexafluorophosphate,
[(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)oxy]tris-(pyrrolidino)phospho-
nium hexafluorophosphate,
[(3,4-dihydro-4-oxo-5-azabenzo-1,2,3-triazin-3-yl]tris-(pyrrolidino)
phosphonium hexafluorophosphate and a derivative thereof, but the
present invention is not limited thereto.
[0057] The enzyme may be transglutaminase, sortase A, tyrosinase,
laccase/peroxidase or lysyl oxidase/amine oxidase, which mediates
bioconjugation between the amine of glutamine and the amine of
lysine, but the present invention is not limited thereto.
[0058] The reaction mediator may be used at 0.000001 to 10 parts by
weight, 0.001 to 7 parts by weight, or 0.01 to 5 parts by weight
with respect to 100 parts by weight of the total composition. When
the content of the reaction mediator is less than 0.000001 part by
weight, it is difficult to exhibit a continuous surface improvement
effect, and when the content of the reaction mediator is more than
10 parts by weight, the reaction mediator excessively present in an
amount higher than a reaction position present in a substrate
consisting of a protein reacts with a functional component while
not reacting with the protein substrate, and thus it does not help
to improve the sustainability of glossiness, and is rather
lost.
[0059] This reaction may be performed under a condition of pH 2 to
pH 12, and more preferably, at pH 3 to pH 10, and most preferably,
in a weakly acidic aqueous solution of pH 4.5 to pH 8 to maximize
reaction efficiency. The reaction is finished within 1 minute to 30
minutes.
[0060] The composition may be used by coating, spraying, dilution,
or other similar methods, and dehydration may be promoted under a
mild condition such as an elevated temperature (20 to 80.degree.
C.) at which thermal denaturation of a protein does not occur, and
thus the reaction efficiency may be enhanced.
[0061] In one exemplary embodiment, using a carbodiimide-based
compound as a reaction mediator, a reaction between a carboxyl
group on the surface of the substrate consisting of a protein and
an amine group of triethoxyaminopropylsilane is illustrated in
Reaction Scheme 1 below.
##STR00005##
[0062] As shown in Reaction Scheme 1, an amino acid linked to hair,
scalp, skin, finger/toe nails, leather and/or fiber is not easily
detached in general cleansing with a shampoo, a detergent or a
soap, and thus the structure attached to the hair, scalp, skin,
finger/toe nails, leather and/or fiber may be almost permanently
maintained.
[0063] The composition for enhancing protein strength according to
the present invention may further include a component capable of
improving a protein strength enhancement effect, other than the
aminosilane compound and the reaction mediator. For example, the
composition may be easily prepared when mixed with a fatty acid
such as palmitic acid, stearic acid, lauric acid or myristic acid,
a cationic surfactant such as a fatty alcohol, or a linear or
branched long-chain alkyl quaternary ammonium salt, a cationic
polymer such as cationic cellulose, cationic guar gum or cationic
polyvinylpyrrolidone, or silicone. In addition, for formulation as
a cosmetic preparation, components for preparing a cosmetic such as
a solvent, a surfactant, a thickening agent, a stabilizer, a
preservative, a coloring agent, a pH adjustor, a sequestering
agent, a coloring agent, a pearlizing agent, an appearance
improving agent, a pigment and powder particles may be further
included. The components for preparation may be used at 40 to 99
parts by weight with respect to 100 parts by weight of the total
composition.
[0064] The composition for enhancing protein strength according to
the present invention may include an aminosilane compound with a
functional group and thus is able to be used in the formulation of
a composition for enhancing protein strength. Examples of the
composition for hair may include all cosmetic preparations capable
of being used for hair, for example, a pre-shampoo product, a
shampoo, a rinse, a treatment, a wax, a spray, a mousse, a hair
lotion, an essence, a hair cream, a pack, a mask, a tablet, a
patch, a strip, a slave, a permanent hair dye, a temporary hair dye
and a hair waving agent, examples of the composition for skin may
include all cosmetic preparations capable of being used for skin,
for example, a skin toner, a lotion, an essence, a serum, a cream,
a gel, a foundation, a powder, a makeup base, a point makeup
product, a mask and a patch, examples of the composition for fabric
may include all fabric care preparations capable of being used in
fabric, for example, a fabric softener, a fabric dye, a washing
detergent, a treatment, a pre/after care agent, a laundry
supplement, a spot stain remover and a spray. Examples of the
composition for leather may include all preparations for treating
leather, for example, a cream, a lotion, an essence, a serum, a
gel, a wax, a spray, a cleanser, a cleaner, a spot stain remover, a
salve, a temporary dye, a permanent dye, a polish, a stripping
agent and a sheet, but the present invention is not limited
thereto.
[0065] To enhance the protein strength enhancement effect in the
composition for enhancing protein strength according to the present
invention, a di-basic acid ester oil such as dioctyl succinate,
dioctyl adipate or diethyl sebacate, polyol, polyethylene glycol,
propylene glycol, hexylene glycol, butanediol and their isomers,
and glycerol, benzyl alcohol, ethoxydiglycol and their derivatives
may be used. The above-mentioned solvents increase the permeability
of hair and skin and are used as solvents for a poorly soluble
substance.
[0066] The advantages and features of the present invention, and
methods of attaining the same will be clarified with reference to
examples that will be described below in detail. However, the
present invention may be embodied in a variety of different forms
and is not limited to the examples described below, and the
examples are merely provided to complete the disclosure of the
present invention, and fully inform the scope of the present
invention to those of ordinary skill in the art.
EXAMPLES 1 TO 12 AND COMPARATIVE EXAMPLES 1 TO 4
[0067] Shampoo compositions for enhancing the strength of a hair
protein according to Examples 1 to 12 and Comparative Examples 1 to
4 were prepared with compositions and contents shown in Tables 1
and 2 below. Hair was thoroughly washed with each of the prepared
shampoo compositions, and then about 3 g of a towel-dried hair
tress was prepared, and therefrom, 50 strings of the hair were
randomly extracted to measure a tensile strength using a hair
tensile strength tester, and the result was determined to be hair
tensile strength before use of the composition. Shampooing was
performed 30 times on the specimens prepared from the same tress
using 0.3 g of each composition, and then subjected to the
measurement of tensile strength to evaluate strength variations.
The results obtained from the all compositions were compared.
TABLE-US-00001 TABLE 1 Example Example Example Example Example
Example Example Example Example Example Example Example (Parts by
weight) 1 2 3 4 5 6 7 8 9 10 11 12 Water To To To To To To To To To
To To To 100 100 100 100 100 100 100 100 100 100 100 100
Polyquaternium-10 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5
EDTA 4Na 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05
0.05 Sodium Lauryl 35 35 35 35 35 35 35 35 35 35 35 35 Ether(2
mole) Sulfate (30%) Cocamidopropyl 15 15 15 15 15 15 15 15 15 15 15
15 Betaine (30%) Fragrance 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9
0.9 0.9 3- 0.5 -- -- -- 0.5 -- -- -- 0.2 0.2 0.5 0.5
aminopropyltriethoxysilane 3- 0.5 -- -- -- 0.5 -- -- -- 0.2 0.2 --
-- aminopropylmethyldiethoxy- silane 3- -- 0.5 -- -- -- 0.5 -- --
0.2 0.2 -- -- aminopropyldimethylethoxy- silane p- -- -- -- 0.5 --
-- -- 0.5 0.2 0.2 -- -- aminophenyltriethoxysilane Benzene,
1,3-bis(1- 1 1 1 1 -- -- -- -- -- 0.5 -- --
isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol
mono-Me-ether- blocked 1,1'- methylene-bis-(4- -- -- -- -- 1 1 1 1
1 0.5 -- -- isocyanatocyclohexane)-, homopolymer, polyethylene
glycol mono-Me-ether-blocked N-[(1H-benzotriazole-1- -- -- -- -- --
-- -- -- -- -- 1 -- yl)(dimethylamino) methylene]-N-
methylmethaneaminium hexafluorophosphate N-oxide Benzotriazole-1-
-- -- -- -- -- -- -- -- -- -- -- 1 yloxytris(dimethylamino)
phosphonium hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s.
q.s. q.s. q.s. q.s. q.s. q.s. q.s. q.s. Total 100 100 100 100 100
100 100 100 100 100 100 100
TABLE-US-00002 TABLE 2 (Parts by weight) Comparative Comparative
Comparative Comparative Example 1 Example 2 Example 3 Example 4
Water To 100 To 100 To 100 To 100 Polyquaternium-10 0.5 0.5 0.5 0.5
EDTA 4Na 0.05 0.05 0.05 0.05 Sodium Lauryl Ether(2 mole) Sulfate
(30%) 35 35 35 35 Cocamidopropyl Betaine (30%) 15 15 15 15
Fragrance 0.9 0.9 0.9 0.9 3-aminopropyl triethoxysilane 0.5 -- --
-- 3-aminopropylmethyldiethoxysilane -- 0.5 -- --
3-aminopropyldimethylethoxysilane -- -- 0.5 --
p-aminophenyltriethoxysilane -- -- -- 0.5 Benzene,
1,3-bis(1-isocyanato-1- -- -- -- -- methylethyl)-, homopolymer,
polyethylene glycol mono-Me-ether-blocked 1,1'-methylene-bis-(4- --
-- -- -- isocyanatocyclohexane)-, homopolymer, polyethylene glycol
mono-Me-ether-blocked N-[(1H-benzotriazole-1- -- -- -- --
yl)(dimethylamino)methylene]-N- methylmethaneaminium
hexafluorophosphate N-oxide
Benzotriazole-1-yloxytris(dimethylamino) -- -- -- -- phosphonium
hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s. Total 100 100
100 100
TABLE-US-00003 TABLE 3 Example Example Example Example Example
Example Example Example Example Example Example Example 1 2 3 4 5 6
7 8 9 10 11 12 Tensile 56.3 55.2 53.3 52.9 76.3 75.2 73.4 73 75.8
76.9 55.2 53.1 strength increase rate (%)
TABLE-US-00004 TABLE 4 Comparative Comparative Comparative
Comparative Example 1 Example 2 Example 3 Example 4 Tensile 31.6
28.3 25.6 20.3 strength Increase rate (%)
[0068] As shown in Tables 3 and 4, the experiments for the
compositions of Examples 1 to 12 and Comparative Examples 1 to 4
showed that, compared to the compositions of Comparative Examples 1
to 4 including only an aminosilane component without a reaction
mediator, the compositions including, as a reaction mediator,
benzene, 1,3-bis(1-isocyanato-1-methylethyl)-, homopolymer,
polyethylene glycol mono-Me-ether-blocked (Examples 1 to 4 and 10)
or 1,1'-methylene-bis-(4-isocyanatocyclohexane)-, homopolymer,
polyethylene glycol mono-Me-ether-blocked (Examples 5 to 10),
N-[(1H-benzotriazole-1-yl)
(dimethylamino)methylene]-N-methylmethaneaminium
hexafluorophosphate N-oxide (Example 11) and
benzotriazole-1-yloxytris(dimethylamino)phosphonium
hexafluorophosphate (Example 12) exhibit a very excellent hair
tensile strength enhancement effect after the use of the
shampoos.
EXAMPLES 13 TO 24 AND COMPARATIVE EXAMPLES 5 TO 8
[0069] Body wash compositions for enhancing elasticity through skin
strengthening according to Examples 13 to 24 and Comparative
Examples 5 to 8 were prepared with compositions and contents shown
in Tables 5 and 6. The initial elasticity of artificial skin was
measured, the elasticity of artificial skin after 30 times of use
was assessed using each composition prepared previously, and the
skin elasticity enhancement effect of the compositions were
compared.
TABLE-US-00005 TABLE 5 Example Example Example Example Example
Example Example Example Example Example Example Example (Parts by
weight) 13 14 15 16 17 18 19 20 21 22 23 24 Water To To To To To To
To To To To To To 100 100 100 100 100 100 100 100 100 100 100 100
Polyquaternium-7 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5
EDTA 4Na 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05
0.05 Lauric Acid 3 3 3 3 3 3 3 3 3 3 3 3 Myristic acid 4 4 4 4 4 4
4 4 4 4 4 4 Sodium Lauryl Ether 20 20 20 20 20 20 20 20 20 20 20 20
(2 mole) Sulfate (30%) Cocamidopropyl 15 15 15 15 15 15 15 15 15 15
15 15 Betaine (30%) Fragrance 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9
0.9 0.9 0.9 3- 0.5 -- -- -- 0.5 -- -- -- 0.2 0.2 0.5 0.5
aminopropyltriethoxysilane 3- -- 0.5 -- -- -- 0.5 -- -- 0.2 0.2 --
-- aminopropylmethyldiethoxy- silane 3- -- -- 0.5 -- -- -- 0.5 --
0.2 0.2 -- -- aminopropyldimethylethoxy- silane p- -- -- -- 0.5 --
-- -- 0.5 0.2 0.2 -- -- aminophenyltriethoxysilane Benzene,
1,3-bis(1- 1 1 1 1 -- -- -- -- -- 0.5 -- --
isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol
mono-Me-ether-blocked 1,1'- methylene-bis-(4- -- -- -- -- 1 1 1 1 1
0.5 -- -- isocyanatocyclohexane)-, homopolymer, polyethylene glycol
mono-Me-ether-blocked N-[(1H-benzotriazole-1- yl)(dimethylamino)
methylene]-N- -- -- -- -- -- -- -- -- -- -- 1 --
methylmethaneaminium hexafluorophosphate N-oxide Benzotriazole-1-
-- -- -- -- -- -- -- -- -- -- -- 1 yloxytris(dimethylamino)
phosphonium hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s.
q.s. q.s. q.s. q.s. q.s. q.s. q.s. q.s. Total 100 100 100 100 100
100 100 100 100 100 100 100
TABLE-US-00006 TABLE 6 (Parts by weight) Comparative Comparative
Comparative Comparative Example 5 Example 6 Example 7 Example 8
Water To 100 To 100 To 100 To 100 Polyquaternium-7 0.5 0.5 0.5 0.5
EDTA 4Na 0.05 0.05 0.05 0.05 Lauric Acid 3 3 3 3 Myristic acid 4 4
4 4 Sodium Lauryl Ether (2 mole) Sulfate (30%) 20 20 20 20
Cocamidopropyl Betaine (30%) 15 15 15 15 Fragrance 0.9 0.9 0.9 0.9
3-aminopropyltriethoxysilane 0.5 -- -- --
3-aminopropylmethyldiethoxysilane -- 0.5 -- --
3-aminopropyldimethylethoxysilane -- -- 0.5 --
p-aminophenyltriethoxysilane -- -- -- 0.5 Benzene,
1,3-bis(1-isocyanato-1- -- -- -- -- methylethyl)-, homopolymer,
polyethylene glycol mono-Me-ether-blocked 1,1'-methylene-bis-(4- --
-- -- -- isocyanatocyclohexane)-, homopolymer, polyethylene glycol
mono-Me-ether-blocked N-[(1H-benzotriazole-1- -- -- -- --
yl)(dimethylamino)methylene]-N- methylmethaneaminium
hexafluorophosphate N-oxide
Benzotriazole-1-yloxytris(dimethylamino) -- -- -- -- phosphonium
hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s. Total 100 100
100 100
TABLE-US-00007 TABLE 7 Example Example Example Example Example
Example Example Example Example Example Example Example 13 14 15 16
17 18 19 20 21 22 23 24 Skin 23.2 22.1 22 20.9 23.1 22.3 22.1 20
33.4 34.7 21.7 22.2 elasticity increase rate (%)
TABLE-US-00008 TABLE 8 Comparative Comparative Comparative
Comparative Example 5 Example 6 Example 7 Example 8 Skin elasticity
10.2 9.8 9.7 8.5 increase rate (%)
[0070] As shown in Tables 7 and 8, the experiments for the
compositions according to Examples 13 to 24 and Comparative
Examples 5 to 8 showed that, compared to the compositions of
Comparative Examples 5 to 8 including only an amino acid component
without a reaction mediator, the compositions including, as a
reaction mediator, benzene, 1,3-bis(1-isocyanato-1-methylethyl)-,
homopolymer, polyethylene glycol mono-Me-ether-blocked (Examples 13
to 16 and 22) or 1,1'-methylene-bis-(4-isocyanatocyclohexane)-,
homopolymer, polyethylene glycol mono-Me-ether-blocked (Examples 17
to 22), N-[(1H-benzotriazole-1-yl)
(dimethylamino)methylene]-N-methylmethaneaminium
hexafluorophosphate N-oxide (Example 23) and
benzotriazole-1-yloxytris(dimethylamino)phosphonium
hexafluorophosphate (Example 24) exhibit a very excellent skin
elasticity improvement effect after the use of the body washes.
EXAMPLES 25 TO 36 AND COMPARATIVE EXAMPLES 9 TO 12
[0071] Compositions for strengthening nails according to Examples
25 to 36 and Comparative Examples 9 to 12 were prepared with
compositions and contents shown in Tables 9 and 10 below. Each
composition was used on 10 consumers for 20 days, and then
conditions of nails such as splitting or cracking were compared to
those of the initial conditions of the nails, and sensory evaluated
on a 5-point scale (5: very good, 4: good, 3: no difference, 2:
almost no effect, 1: no effect at all) for comparison.
TABLE-US-00009 TABLE 9 Example Example Example Example Example
Example Example Example Example Example Example Example (Parts by
weight) 25 26 27 28 29 30 31 32 33 34 35 36 Water To To To To To To
To To To To To To 100 100 100 100 100 100 100 100 100 100 100 100
Amodimethicone 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5
18-Methyl Eicosanoic 1 1 1 1 1 1 1 1 1 1 1 1 Acid Isostearylamine 1
1 1 1 1 1 1 1 1 1 1 1 Glycerin 2 2 2 2 2 2 2 2 2 2 2 2 Butylene
glycol 2 2 2 2 2 2 2 2 2 2 2 2 Propylene glycol 2 2 2 2 2 2 2 2 2 2
2 2 Fragrance 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9
Carboxyvinyl polymer 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
0.1 Polysolvate 60 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
Liquid paraffin 5 5 5 5 5 5 5 5 5 5 5 5 Caprylic/capric 2.5 2.5 2.5
2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 triglyceride Squalane 2.5 2.5
2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 Cetearyl glucoside 2 2 2 2
2 2 2 2 2 2 2 2 Triethanolamine 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
0.1 0.1 0.1 3- 0.5 -- -- -- 0.5 -- -- -- 0.2 0.2 0.5 0.5
aminopropyltriethoxysilane 3- -- 0.5 -- -- -- 0.5 -- -- 0.2 0.2 --
-- aminopropylmethyldiethoxy- silane 3- -- -- 0.5 -- -- -- 0.5 --
0.2 0.2 -- -- aminopropyldimethylethoxy- silane p- -- -- -- 0.5 --
-- -- 0.5 0.2 0.2 -- -- aminophenyltriethoxysilane Benzene,
1,3-bis(1- 1 1 1 1 -- -- -- -- -- 0.5 -- -- isocyanato-1-
methylethyl)-, homopolymer, polyethylene glycol
mono-Me-ether-blocked 1,1'-methylene-bis-(4- -- -- -- -- 1 1 1 1 1
0.5 -- -- isocyanatocyclohexane)-, homopolymer, polyethylene glycol
mono-Me-ether-blocked N-[(1H-benzotriazole-1- -- -- -- -- -- -- --
-- -- -- 1 -- yl)(dimethylamino) methylene]-N- methylmethaneaminium
hexafluorophosphate N-oxide Benzotriazole-1- -- -- -- -- -- -- --
-- -- -- -- 1 yloxytris(dimethylamino) phosphonium
hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s. q.s. q.s. q.s.
q.s. q.s. q.s. q.s. q.s. Total 100 100 100 100 100 100 100 100 100
100 100 100
TABLE-US-00010 TABLE 10 (Parts by weight) Comparative Comparative
Comparative Comparative Example 9 Example 10 Example 11 Example 12
Water To 100 To 100 To 100 To 100 Amodimethicone 0.5 0.5 0.5 0.5
18-Methyl Eicosanoic Acid 1 1 1 1 Isostearylamine 1 1 1 1 Glycerin
2 2 2 2 Butylene glycol 2 2 2 2 Propylene glycol 2 2 2 2 Fragrance
0.9 0.9 0.9 0.9 Carboxyvinyl polymer 0.1 0.1 0.1 0.1 Polysolvate 60
1.5 1.5 1.5 1.5 Liquid paraffin 5 5 5 5 Caprylic/caprictriglyceride
2.5 2.5 2.5 2.5 Squalane 2.5 2.5 2.5 2.5 Cetearyl glucoside 2 2 2 2
triethanolamine 0.1 0.1 0.1 0.1 3-aminopropyltriethoxysilane 0.5 --
-- -- 3-aminopropylmethyldiethoxysilane -- 0.5 -- --
3-aminopropyldimethylethoxysilane -- -- 0.5 --
p-aminophenyltriethoxysilane -- -- -- 0.5 Benzene,
1,3-bis(1-isocyanato-1- -- -- -- -- methylethyl)-, homopolymer,
polyethylene glycol mono-Me-ether-blocked 1,1'-methylene-bis-(4- --
-- -- -- isocyanatocyclohexane)-, homopolymer, polyethylene glycol
mono-Me-ether-blocked N-[(1H-benzotriazole-1- -- -- -- --
yl)(dimethylamino)methylene]-N- methylmethaneaminium
hexafluorophosphate N-oxide
Benzotriazole-1-yloxytris(dimethylamino) -- -- -- -- phosphonium
hexafluorophosphate pH adjustor q.s. q.s. q.s. q.s. Total 100 100
100 100
TABLE-US-00011 TABLE 11 Example Example Example Example Example
Example Example Example Example Example Example Example 25 26 27 28
29 30 31 32 33 34 35 36 Satisfaction 3.7 3.7 3.6 3.8 4.1 4 4 3.9
4.2 4.4 3.6 3.6 of nail strength improvement effect (5-point
scale)
TABLE-US-00012 TABLE 12 Comparative Comparative Comparative
Comparative Example 9 Example 10 Example 11 Example 12 Satisfaction
of 2.2 2.4 2.2 2.1 nail strength improvement effect (5-point
scale)
[0072] As shown in Tables 11 and 12, experiments for the
compositions according to Examples 25 to 36 and Comparative
Examples 9 to 12 showed that, compared to the compositions of
Comparative Examples 9 to 12 including only an amino acid component
without a reaction mediator, the compositions including, as a
reaction mediator, benzene, 1,3-bis(1-isocyanato-1-methylethyl)-,
homopolymer, polyethylene glycol mono-Me-ether-blocked (Examples 25
to 28 and 34) or 1,1'-methylene-bis-(4-isocyanatocyclohexane)-,
homopolymer, polyethylene glycol mono-Me-ether-blocked (Examples 29
to 34), N-[(1H-benzotriazole-1-yl)
(dimethylamino)methylene]-N-methylmethaneaminium
hexafluorophosphate N-oxide (Example 35), and
benzotriazole-1-yloxytris(dimethylamino)phosphonium
hexafluorophosphate (Example 36) exhibit a very excellent nail
strength enhancement effect.
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