U.S. patent application number 16/456773 was filed with the patent office on 2019-10-17 for rna viruses expressing il-12 for immunovirotherapy. This patent application is currently assigned to DEUTSCHES KREBSFORSCHUNGSZENTRUM. The applicant listed for this patent is DEUTSCHES KREBSFORSCHUNGSZENTRUM, RUPRECHT-KARLS UNIVERSITAET. Invention is credited to Christine ENGELAND, Guy UNGERECHTS, Ruta VEINALDE.
Application Number | 20190315825 16/456773 |
Document ID | / |
Family ID | 59678868 |
Filed Date | 2019-10-17 |
United States Patent Application | 20190315825 |
Kind Code | A1 |
UNGERECHTS; Guy ; et al. | October 17, 2019 |
The present invention relates to a recombinant virus of the family Paramyxoviridae, comprising at least one expressible polynucleotide encoding an IL-12 polypeptide, wherein said IL-12 polypeptide is an IL-12 fusion polypeptide comprising a p35 subunit of an IL-12 and a p40 subunit of an IL-12; to a polynucleotide encoding the same, and to a kit comprising the same. Moreover, the present invention relates to a method for treating cancer in a subject afflicted with cancer, comprising contacting said subject with a recombinant virus of the family Paramyxoviridae of the invention, and thereby, treating cancer in a subject afflicted with cancer.
Inventors: | UNGERECHTS; Guy; (Heidelberg, DE) ; ENGELAND; Christine; (Heidelberg, DE) ; VEINALDE; Ruta; (Heidelberg, DE) | ||||||||||
Applicant: |
|
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Assignee: | DEUTSCHES
KREBSFORSCHUNGSZENTRUM Heidelberg DE RUPRECHT-KARLS UNIVERSITAET Heidelberg DE |
||||||||||
Family ID: | 59678868 | ||||||||||
Appl. No.: | 16/456773 | ||||||||||
Filed: | June 28, 2019 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
15441545 | Feb 24, 2017 | 10344067 | ||
16456773 | ||||
62299788 | Feb 25, 2016 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | A61K 2039/5256 20130101; C12N 2760/18043 20130101; A61K 38/00 20130101; C12N 2760/18432 20130101; C07K 14/5434 20130101; C12N 2760/18443 20130101; C07K 16/2827 20130101; C07K 16/3007 20130101; A61K 2039/507 20130101; A61K 2039/505 20130101; C07K 16/2887 20130101; C07K 16/2818 20130101; C07K 2317/622 20130101 |
International Class: | C07K 14/54 20060101 C07K014/54; C07K 16/30 20060101 C07K016/30; C07K 16/28 20060101 C07K016/28 |
Sequence CWU 1
1
1715PRTArtificialartificial linker sequence 1Gly Gly Gly Gly Ser1
52502PRTArtificialanti-human PD-L1 single-chain antibody 2Met Glu
Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro1 5 10 15Asp
Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 20 25
30Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser
35 40 45Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala
Pro 50 55 60Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile
Pro Ala65 70 75 80Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Thr Ile Ser 85 90 95Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln Gln Arg Ser 100 105 110Asn Trp Pro Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Arg Gly 115 120 125Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gln Val 130 135 140Gln Leu Val Gln Ser
Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val145 150 155 160Lys Val
Ser Cys Lys Thr Ser Gly Asp Thr Phe Ser Thr Tyr Ala Ile 165 170
175Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly
180 185 190Ile Ile Pro Ile Phe Gly Lys Ala His Tyr Ala Gln Lys Phe
Gln Gly 195 200 205Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr
Ala Tyr Met Glu 210 215 220Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
Val Tyr Phe Cys Ala Arg225 230 235 240Lys Phe His Phe Val Ser Gly
Ser Pro Phe Gly Met Asp Val Trp Gly 245 250 255Gln Gly Thr Thr Val
Thr Val Ser Ser Val Asp Glu Ala Lys Ser Cys 260 265 270Asp Lys Thr
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 275 280 285Gly
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295
300Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
His305 310 315 320Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly Val Glu Val 325 330 335His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Tyr Asn Ser Thr Tyr 340 345 350Arg Val Val Ser Val Leu Thr Val
Leu His Gln Asp Trp Leu Asn Gly 355 360 365Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 370 375 380Glu Lys Thr Ile
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val385 390 395 400Tyr
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410
415Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
420 425 430Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
Pro Pro 435 440 445Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
Lys Leu Thr Val 450 455 460Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser Cys Ser Val Met465 470 475 480His Glu Ala Leu His Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser 485 490 495Pro Gly Lys Val Asp
Asn 50031509DNAArtificialanti-human PD-L1 single-chain antibody
encoding sequence 3atggaaaccc cagcacagct tctcttcctc ctgctgctct
ggctcccaga taccactgga 60gagattgtcc tgacacagag cccagctaca ctttccctgt
ctccgggcga aagagcaacc 120ctctcttgca gggctagcca gtctgtcagc
tcttatctcg cctggtatca gcagaaacca 180ggccaggctc ccagactgct
gatctacgac gctagcaatc gcgccactgg cataccagca 240cgcttttcag
ggtccggcag tggtaccgac ttcaccctga ccatctcctc actggaacct
300gaggactttg ccgtgtatta ctgtcaacag cggagtaact ggcccacctt
tgggcagggc 360actaaggtgg agatcaaacg cggtggtggt ggatcaggtg
gaggcggaag tggaggtggc 420ggatcccagg tgcaactggt acagagcggc
gcagaagtga agaaacccgg gtcctcagtg 480aaggtcagtt gcaagacatc
cggggacacc ttctcaacgt atgccattag ctgggttaga 540caggctcctg
gtcaagggct tgagtggatg ggaggtatca ttcccatatt cgggaaagcg
600cattatgccc agaagttcca aggcagggtc accatcactg ccgatgaatc
cacaagtact 660gcctacatgg agttgagctc cttgcgtagc gaggatactg
cggtgtactt ttgtgcacgg 720aagtttcact tcgtttcagg gagccctttc
gggatggatg tttggggaca gggtacaacg 780gtgacagtat ccagcgtcga
cgaggccaaa tcttgtgaca aaactcacac atgcccaccg 840tgcccagcac
ccgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag
900gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga
cgtgagccac 960gaagaccctg aggtcaagtt caactggtac gtggacggcg
tggaggtgca taatgccaag 1020acaaagccgc gggaggagca gtacaacagc
acgtaccgtg tggtcagcgt cctcaccgtc 1080ctgcaccagg actggctgaa
tggcaaggag tacaagtgca aggtctccaa caaagccctc 1140ccagccccca
tcgagaaaac catctccaaa gccaaggggc agccccgaga accacaggtg
1200tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct
gacctgcctg 1260gtcaaaggct tctatcccag cgacatcgcc gtggagtggg
agagcaatgg gcagccggag 1320aacaactaca agaccacgcc tcccgtgctg
gactccgacg gctccttctt cctctacagc 1380aagctcaccg tggacaagag
caggtggcag caggggaacg tcttctcatg ctccgtgatg 1440catgaggctc
tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaagtc
1500gacaattaa 1509417610DNAArtificialrecombinant MV genome
MeVac_P-FmIL-12 4accaaacaaa gttgggtaag gatagttcaa tcaatgatca
tcttctagtg cacttaggat 60tcaagatcct attatcaggg acaagagcag gattagggat
atccgagatg gccacacttt 120taaggagctt agcattgttc aaaagaaaca
aggacaaacc acccattaca tcaggatccg 180gtggagccat cagaggaatc
aaacacatta ttatagtacc aatccctgga gattcctcaa 240ttaccactcg
atccagactt ctggaccggt tggtgaggtt aattggaaac ccggatgtga
300gcgggcccaa actaacaggg gcactaatag gtatattatc cttatttgtg
gagtctccag 360gtcaattgat tcagaggatc accgatgacc ctgacgttag
cataaggctg ttagaggttg 420tccagagtga ccagtcacaa tctggcctta
ccttcgcatc aagaggtacc aacatggagg 480atgaggcgga ccaatacttt
tcacatgatg atccaattag tagtgatcaa tccaggttcg 540gatggttcgg
gaacaaggaa atctcagata ttgaagtgca agaccctgag ggattcaaca
600tgattctggg taccatccta gcccaaattt gggtcttgct cgcaaaggcg
gttacggccc 660cagacacggc agctgattcg gagctaagaa ggtggataaa
gtacacccaa caaagaaggg 720tagttggtga atttagattg gagagaaaat
ggttggatgt ggtgaggaac aggattgccg 780aggacctctc cttacgccga
ttcatggtcg ctctaatcct ggatatcaag agaacacccg 840gaaacaaacc
caggattgct gaaatgatat gtgacattga tacatatatc gtagaggcag
900gattagccag ttttatcctg actattaagt ttgggataga aactatgtat
cctgctcttg 960gactgcatga atttgctggt gagttatcca cacttgagtc
cttgatgaac ctttaccagc 1020aaatggggga aactgcaccc tacatggtaa
tcctggagaa ctcaattcag aacaagttca 1080gtgcaggatc ataccctctg
ctctggagct atgccatggg agtaggagtg gaacttgaaa 1140actccatggg
aggtttgaac tttggccgat cttactttga tccagcatat tttagattag
1200ggcaagagat ggtaaggagg tcagctggaa aggtcagttc cacattggca
tctgaactcg 1260gtatcactgc cgaggatgca aggcttgttt cagagattgc
aatgcatact actgaggaca 1320agatcagtag agcggttgga cccagacaag
cccaagtatc atttctacac ggtgatcaaa 1380gtgagaatga gctaccgaga
ttggggggca aggaagatag gagggtcaaa cagagtcgag 1440gagaagccag
ggagagctac agagaaaccg ggcccagcag agcaagtgat gcgagagctg
1500cccatcttcc aaccggcaca cccctagaca ttgacactgc aacggagtcc
agccaagatc 1560cgcaggacag tcgaaggtca gctgacgccc tgcttaggct
gcaagccatg gcaggaatct 1620cggaagaaca aggctcagac acggacaccc
ctatagtgta caatgacaga aatcttctag 1680actaggtgcg agaggccgag
ggccagaaca acatccgcct accatccatc attgttataa 1740aaaacttagg
aaccaggtcc acacagccgc cagcccatca accatccact cccacgattg
1800gagccaatgg cagaagagca ggcacgccat gtcaaaaacg gactggaatg
catccgggct 1860ctcaaggccg agcccatcgg ctcactggcc atcgaggaag
ctatggcagc atggtcagaa 1920atatcagaca acccaggaca ggagcgagcc
acctgcaggg aagagaaggc aggcagttcg 1980ggtctcagca aaccatgcct
ctcagcaatt ggatcaactg aaggcggtgc acctcgcatc 2040cgcggtcagg
gacctggaga gagcgatgac gacgctgaaa ctttgggaat ccccccaaga
2100aatctccagg catcaagcac tgggttacag tgttattacg tttatgatca
cagcggtgaa 2160gcggttaagg gaatccaaga tgctgactct atcatggttc
aatcaggcct tgatggtgat 2220agcaccctct caggaggaga caatgaatct
gaaaacagcg atgtggatat tggcgaacct 2280gataccgagg gatatgctat
cactgaccgg ggatctgctc ccatctctat ggggttcagg 2340gcttctgatg
ttgaaactgc agaaggaggg gagatccacg agctcctgag actccaatcc
2400agaggcaaca actttccgaa gcttgggaaa actctcaatg ttcctccgcc
cccggacccc 2460ggtagggcca gcacttccgg gacacccatt aaaaagggca
cagacgcgag attagcctca 2520tttggaacgg agatcgcgtc tttattgaca
ggtggtgcaa cccaatgtgc tcgaaagtca 2580ccctcggaac catcagggcc
aggtgcacct gcggggaatg tccccgagtg tgtgagcaat 2640gccgcactga
tacaggagtg gacacccgaa tctggtacca caatctcccc gagatcccag
2700aataatgaag aagggggaga ctattatgat gatgagctgt tctctgatgt
ccaagatatt 2760aaaacagcct tggccaaaat acacgaggat aatcagaaga
taatctccaa gctagaatca 2820ctgctgttat tgaagggaga agttgagtca
attaagaagc agatcaacag gcaaaatatc 2880agcatatcca ccctggaagg
acacctctca agcatcatga tcgccattcc tggacttggg 2940aaggatccca
acgaccccac tgcagatgtc gaaatcaatc ccgacttgaa acccatcata
3000ggcagagatt caggccgagc actggccgaa gttctcaaga aacccgttgc
cagccgacaa 3060ctccaaggaa tgacaaatgg acggaccagt tccagaggac
agctgctgaa ggaatttcag 3120ctaaagccga tcgggaaaaa gatgagctca
gccgtcgggt ttgttcctga caccggccct 3180gcatcacgca gtgtaatccg
ctccattata aaatccagcc ggctagagga ggatcggaag 3240cgttacctga
tgactctcct tgatgatatc aaaggagcca atgatcttgc caagttccac
3300cagatgctga tgaagataat aatgaagtag ctacagctca acttacctgc
caaccccatg 3360ccagtcgacc caactagcaa cctaaatcca ttataaaaaa
cttaggaacc aggtccacac 3420agctcgagtc gcgcgtggcc accatgtgtc
ctcagaagct aaccatctcc tggtttgcca 3480tcgttttgct ggtgtcccca
ctcatggcca tgtgggagct ggagaaagac gtttatgttg 3540tagaggtgga
ctggactccc gatgcccctg gagaaacagt gaacctcacc tgtgacacgc
3600ctgaagaaga tgacatcacc tggacctcag accagagaca tggagtcata
ggctctggaa 3660agaccctgac catcactgtc aaagagtttc tagatgctgg
ccagtacacc tgccacaaag 3720gaggcgagac tctgagccac tcacatctgc
tgctccacaa gaaggaaaat ggaatttggt 3780ccactgaaat tttaaaaaat
ttcaaaaaca agactttcct gaagtgtgaa gcaccaaatt 3840actccggacg
gttcacgtgc tcatggctgg tgcaaagaaa catggacttg aagttcaaca
3900tcaagagcag tagcagttcc cctgactctc gggcagtgac atgtggaatg
gcgtctctgt 3960ctgcagagaa ggtcacactg gaccaaaggg actatgagaa
gtattcagtg tcctgccagg 4020aggatgtcac ctgcccaact gccgaggaga
ccctgcccat tgaactggcg ttggaagcac 4080ggcagcagaa taaatatgag
aactacagca ccagcttctt catcagggac atcatcaaac 4140cagacccgcc
caagaacttg cagatgaagc ctttgaagaa ctcacaggtg gaggtcagct
4200gggagtaccc tgactcctgg agcactcccc attcctactt ctccctcaag
ttctttgttc 4260gaatccagcg caagaaagaa aagatgaagg agacagagga
ggggtgtaac cagaaaggtg 4320cgttcctcgt agagaagaca tctaccgaag
tccaatgcaa aggcgggaat gtctgcgtgc 4380aagctcagga tcgctattac
aattcctcgt gcagcaagtg ggcatgtgtt ccctgcaggg 4440tccgatccgg
tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga tctagggtca
4500ttccagtctc tggacctgcc aggtgtctta gccagtcccg aaacctgctg
aagaccacag 4560atgacatggt gaagacggcc agagaaaaac tgaaacatta
ttcctgcact gctgaagaca 4620tcgatcatga agacatcaca cgggaccaaa
ccagcacatt gaagacctgt ttaccactgg 4680aactacacaa gaacgagagt
tgcctggcta ctagagagac ttcttccaca acaagaggga 4740gctgcctgcc
cccacagaag acgtctttga tgatgaccct gtgccttggt agcatctatg
4800aggacttgaa gatgtaccag acagagttcc aggccatcaa cgcagcactt
cagaatcaca 4860accatcagca gatcattcta gacaagggca tgctggtggc
catcgatgag ctgatgcagt 4920ctctgaatca taatggcgag actctgcgcc
agaaacctcc tgtgggagaa gcagaccctt 4980acagagtgaa aatgaagctc
tgcatcctgc ttcacgcctt cagcacccgc gtcgtgacca 5040tcaacagggt
gatgggctat ctgagctccg cctgataatc gcgcgcgtgc tagtacaacc
5100taaatccatt ataaaaaact taggagcaaa gtgattgcct cccaaggtcc
acaatgacag 5160agacctacga cttcgacaag tcggcatggg acatcaaagg
gtcgatcgct ccgatacaac 5220ccaccaccta cagtgatggc aggctggtgc
cccaggtcag agtcatagat cctggtctag 5280gcgacaggaa ggatgaatgc
tttatgtaca tgtttctgct gggggttgtt gaggacagcg 5340attccctagg
gcctccaatc gggcgagcat ttgggttcct gcccttaggt gttggcagat
5400ccacagcaaa gcccgaaaaa ctcctcaaag aggccactga gcttgacata
gttgttagac 5460gtacagcagg gctcaatgaa aaactggtgt tctacaacaa
caccccacta actctcctca 5520caccttggag aaaggtccta acaacaggga
gtgtcttcaa cgcaaaccaa gtgtgcaatg 5580cggttaatct gataccgctc
gataccccgc agaggttccg tgttgtttat atgagcatca 5640cccgtctttc
ggataacggg tattacaccg ttcctagaag aatgctggaa ttcagatcgg
5700tcaatgcagt ggccttcaac ctgctggtga cccttaggat tgacaaggcg
ataggccctg 5760ggaagatcat cgacaataca gagcaacttc ctgaggcaac
atttatggtc cacatcggga 5820acttcaggag aaagaagagt gaagtctact
ctgccgatta ttgcaaaatg aaaatcgaaa 5880agatgggcct ggtttttgca
cttggtggga tagggggcac cagtcttcac attagaagca 5940caggcaaaat
gagcaagact ctccatgcac aactcgggtt caagaagacc ttatgttacc
6000cgctgatgga tatcaatgaa gaccttaatc gattactctg gaggagcaga
tgcaagatag 6060taagaatcca ggcagttttg cagccatcag ttcctcaaga
attccgcatt tacgacgacg 6120tgatcataaa tgatgaccaa ggactattca
aagttctgta gaccgtagtg cccagcaatg 6180cccgaaaacg acccccctca
caatgacagc cagaaggccc ggacaaaaaa gccccctccg 6240aaagactcca
cggaccaagc gagaggccag ccagcagccg acggcaagcg cgaacaccag
6300gcggccccag cacagaacag ccctgacaca aggccaccac cagccacccc
aatctgcatc 6360ctcctcgtgg gacccccgag gaccaacccc caaggctgcc
cccgatccaa accaccaacc 6420gcatccccac cacccccggg aaagaaaccc
ccagcaattg gaaggcccct ccccctcttc 6480ctcaacacaa gaactccaca
accgaaccgc acaagcgacc gaggtgaccc aaccgcaggc 6540atccgactcc
ctagacagat cctctctccc cggcaaacta aacaaaactt agggccaagg
6600aacatacaca cccaacagaa cccagacccc ggcccacggc gccgcgcccc
caacccccga 6660caaccagagg gagcccccaa ccaatcccgc cggctccccc
ggtgcccaca ggcagggaca 6720ccaacccccg aacagaccca gcacccaacc
atcgacaatc caagacgggg gggccccccc 6780aaaaaaaggc ccccaggggc
cgacagccag caccgcgagg aagcccaccc accccacaca 6840cgaccacggc
aaccaaacca gaacccagac caccctgggc caccagctcc cagactcggc
6900catcaccccg cagaaaggaa aggccacaac ccgcgcaccc cagccccgat
ccggcgggga 6960gccacccaac ccgaaccagc acccaagagc gatccccgaa
ggacccccga accgcaaagg 7020acatcagtat cccacagcct ctccaagtcc
cccggtctcc tcctcttctc gaagggacca 7080aaagatcaat ccaccacacc
cgacgacact caactcccca cccctaaagg agacaccggg 7140aatcccagaa
tcaagactca tccaatgtcc atcatgggtc tcaaggtgaa cgtctctgcc
7200atattcatgg cagtactgtt aactctccaa acacccaccg gtcaaatcca
ttggggcaat 7260ctctctaaga taggggtggt aggaatagga agtgcaagct
acaaagttat gactcgttcc 7320agccatcaat cattagtcat aaaattaatg
cccaatataa ctctcctcaa taactgcacg 7380agggtagaga ttgcagaata
caggagacta ctgagaacag ttttggaacc aattagagat 7440gcacttaatg
caatgaccca gaatataaga ccggttcaga gtgtagcttc aagtaggaga
7500cacaagagat ttgcgggagt agtcctggca ggtgcggccc taggcgttgc
cacagctgct 7560cagataacag ccggcattgc acttcaccag tccatgctga
actctcaagc catcgacaat 7620ctgagagcga gcctggaaac tactaatcag
gcaattgaga caatcagaca agcagggcag 7680gagatgatat tggctgttca
gggtgtccaa gactacatca ataatgagct gataccgtct 7740atgaaccaac
tatcttgtga tttaatcggc cagaagctcg ggctcaaatt gctcagatac
7800tatacagaaa tcctgtcatt atttggcccc agtttacggg accccatatc
tgcggagata 7860tctatccagg ctttgagcta tgcgcttgga ggagacatca
ataaggtgtt agaaaagctc 7920ggatacagtg gaggtgattt actgggcatc
ttagagagcg gaggaataaa ggcccggata 7980actcacgtcg acacagagtc
ctacttcatt gtcctcagta tagcctatcc gacgctgtcc 8040gagattaagg
gggtgattgt ccaccggcta gagggggtct cgtacaacat aggctctcaa
8100gagtggtata ccactgtgcc caagtatgtt gcaacccaag ggtaccttat
ctcgaatttt 8160gatgagtcat cgtgtacttt catgccagag gggactgtgt
gcagccaaaa tgccttgtac 8220ccgatgagtc ctctgctcca agaatgcctc
cgggggtaca ccaagtcctg tgctcgtaca 8280ctcgtatccg ggtcttttgg
gaaccggttc attttatcac aagggaacct aatagccaat 8340tgtgcatcaa
tcctttgcaa gtgttacaca acaggaacga tcattaatca agaccctgac
8400aagatcctaa catacattgc tgccgatcac tgcccggtag tcgaggtgaa
cggcgtgacc 8460atccaagtcg ggagcaggag gtatccagac gctgtgtact
tgcacagaat tgacctcggt 8520cctcccatat cattggagag gttggacgta
gggacaaatc tggggaatgc aattgctaag 8580ttggaggatg ccaaggaatt
gttggagtca tcggaccaga tattgaggag tatgaaaggt 8640ttatcgagca
ctagcatagt ctacatcctg attgcagtgt gtcttggagg gttgataggg
8700atccccgctt taatatgttg ctgcaggggg cgttgtaaca aaaagggaga
acaagttggt 8760atgtcaagac caggcctaaa gcctgatctt acgggaacat
caaaatccta tgtaaggtcg 8820ctctgatcct ctacaactct tgaaacacaa
atgtcccaca agtctcctct tcgtcatcaa 8880gcaaccaccg cacccagcat
caagcccacc tgaaattatc tccggcttcc ctctggccga 8940acaatatcgg
tagttaatca aaacttaggg tgcaagatca tccacaatgt caccacaacg
9000agaccggata aatgccttct acaaagataa cccccatccc aagggaagta
ggatagtcat 9060taacagagaa catcttatga ttgatagacc ttatgttttg
ctggctgttc tgtttgtcat 9120gtttctgagc ttgatcgggt tgctagccat
tgcaggcatt agacttcatc gggcagccat 9180ctacaccgca gagatccata
aaagcctcag caccaatcta gatgtaacta actcaatcga 9240gcatcaggtc
aaggacgtgc tgacaccact cttcaaaatc atcggtgatg aagtgggcct
9300gaggacacct cagagattca ctgacctagt gaaattaatc tctgacaaga
ttaaattcct 9360taatccggat agggagtacg acttcagaga tctcacttgg
tgtatcaacc cgccagagag 9420aatcaaattg gattatgatc aatactgtgc
agatgtggct gctgaagagc tcatgaatgc 9480attggtgaac tcaactctac
tggagaccag aacaaccaat cagttcctag ctgtctcaaa 9540gggaaactgc
tcagggccca ctacaatcag aggtcaattc tcaaacatgt cgctgtccct
9600gttagacttg tatttaggtc gaggttacaa tgtgtcatct atagtcacta
tgacatccca 9660gggaatgtat gggggaactt acctagtgga aaagcctaat
ctgagcagca aaaggtcaga 9720gttgtcacaa ctgagcatgt accgagtgtt
tgaagtaggt gttatcagaa atccgggttt 9780gggggctccg gtgttccata
tgacaaacta tcttgagcaa ccagtcagta atgatctcag 9840caactgtatg
gtggctttgg gggagctcaa actcgcagcc ctttgtcacg gggaagattc
9900tatcacaatt ccctatcagg gatcagggaa aggtgtcagc ttccagctcg
tcaagctagg 9960tgtctggaaa tccccaaccg acatgcaatc ctgggtcccc
ttatcaacgg atgatccagt 10020gatagacagg ctttacctct catctcacag
aggtgttatc gctgacaatc aagcaaaatg 10080ggctgtcccg acaacacgaa
cagatgacaa gttgcgaatg gagacatgct tccaacaggc 10140gtgtaagggt
aaaatccaag cactctgcga gaatcccgag tgggcaccat tgaaggataa
10200caggattcct tcatacgggg tcttgtctgt tgatctgagt ctgacagttg
agcttaaaat 10260caaaattgct tcgggattcg ggccattgat cacacacggt
tcagggatgg acctatacaa 10320atccaaccac aacaatgtgt attggctgac
tatcccgcca atgaagaacc tagccttagg 10380tgtaatcaac acattggagt
ggataccgag attcaaggtt agtccctacc tcttcactgt 10440cccaattaag
gaagcaggcg aagactgcca tgccccaaca tacctacctg cggaggtgga
10500tggtgatgtc aaactcagtt ccaatctggt gattctacct ggtcaagatc
tccaatatgt 10560tttggcaacc tacgatactt ccagggttga acatgctgtg
gtttattacg tttacagccc 10620aagccgctca ttttcttact tttatccttt
taggttgcct ataaaggggg tccccatcga 10680attacaagtg gaatgcttca
catgggacca aaaactctgg tgccgtcact tctgtgtgct 10740tgcggactca
gaatctggtg gacatatcac tcactctggg atggtgggca tgggagtcag
10800ctgcacagtc acccgggaag atggaaccaa tcgcagatag ggctgctagt
gaaccaatca 10860catgatgtca cccagacatc aggcataccc actagtgtga
aatagacatc agaattaaga 10920aaaacgtagg gtccaagtgg ttccccgtta
tggactcgct atctgtcaac cagatcttat 10980accctgaagt tcacctagat
agcccgatag ttaccaataa gatagtagcc atcctggagt 11040atgctcgagt
ccctcacgct tacagcctgg aggaccctac actgtgtcag aacatcaagc
11100accgcctaaa aaacggattt tccaaccaaa tgattataaa caatgtggaa
gttgggaatg 11160tcatcaagtc caagcttagg agttatccgg cccactctca
tattccatat ccaaattgta 11220atcaggattt atttaacata gaagacaaag
agtcaacgag gaagatccgt gaactcctca 11280aaaaggggaa ttcgctgtac
tccaaagtca gtgataaggt tttccaatgc ttaagggaca 11340ctaactcacg
gcttggccta ggctccgaat tgagggagga catcaaggag aaagttatta
11400acttgggagt ttacatgcac agctcccagt ggtttgagcc ctttctgttt
tggtttacag 11460tcaagactga gatgaggtca gtgattaaat cacaaaccca
tacttgccat aggaggagac 11520acacacctgt attcttcact ggtagttcag
ttgagttgct aatctctcgt gaccttgttg 11580ctataatcag taaagagtct
caacatgtat attacctgac atttgaactg gttttgatgt 11640attgtgatgt
catagagggg aggttaatga cagagaccgc tatgactatt gatgctaggt
11700atacagagct tctaggaaga gtcagataca tgtggaaact gatagatggt
ttcttccctg 11760cactcgggaa tccaacttat caaattgtag ccatgctgga
gcctctttca cttgcttacc 11820tgcagctgag ggatataaca gtagaactca
gaggtgcttt ccttaaccac tgctttactg 11880aaatacatga tgttcttgac
caaaacgggt tttctgatga aggtacttat catgagttaa 11940ctgaagctct
agattacatt ttcataactg atgacataca tctgacaggg gagattttct
12000catttttcag aagtttcggc caccccagac ttgaagcagt aacggctgct
gaaaatgtta 12060ggaaatacat gaatcagcct aaagtcattg tgtatgagac
tctgatgaaa ggtcatgcca 12120tattttgtgg aatcataatc aacggctatc
gtgacaggca cggaggcagt tggccaccgc 12180tgaccctccc cctgcatgct
gcagacacaa tccggaatgc tcaagcttca ggtgaagggt 12240taacacatga
gcagtgcgtt gataactgga aatcttttgc tggagtgaaa tttggctgct
12300ttatgcctct tagcctggat agtgatctga caatgtacct aaaggacaag
gcacttgctg 12360ctctccaaag ggaatgggat tcagtttacc cgaaagagtt
cctgcgttac gaccctccca 12420agggaaccgg gtcacggagg cttgtagatg
ttttccttaa tgattcgagc tttgacccat 12480atgatgtgat aatgtatgtt
gtaagtggag cttacctcca tgaccctgag ttcaacctgt 12540cttacagcct
gaaagaaaag gagatcaagg aaacaggtag actttttgct aaaatgactt
12600acaaaatgag ggcatgccaa gtgattgctg aaaatctaat ctcaaacggg
attggcaaat 12660attttaagga caatgggatg gccaaggatg agcacgattt
gactaaggca ctccacactc 12720tagctgtctc aggagtcccc aaagatctca
aagaaagtca cagggggggg ccagtcttaa 12780aaacctactc ccgaagccca
gtccacacaa gtaccaggaa cgtgagagca gcaaaagggt 12840ttatagggtt
ccctcaagta attcggcagg accaagacac tgatcatccg gagaatatgg
12900aagcttacga gacagtcagt gcatttatca cgactgatct caagaagtac
tgccttaatt 12960ggagatatga gaccatcagc ttgtttgcac agaggctaaa
tgagatttac ggattgccct 13020catttttcca gtggctgcat aagaggcttg
agacctctgt cctgtatgta agtgaccctc 13080attgcccccc cgaccttgac
gcccatatcc cgttatataa agtccccaat gatcaaatct 13140tcattaagta
ccctatggga ggtatagaag ggtattgtca gaagctgtgg accatcagca
13200ccattcccta tctatacctg gctgcttatg agagcggagt aaggattgct
tcgttagtgc 13260aaggggacaa tcagaccata gccgtaacaa aaagggtacc
cagcacatgg ccctacaacc 13320ttaagaaacg ggaagctgct agagtaacta
gagattactt tgtaattctt aggcaaaggc 13380tacatgatat tggccatcac
ctcaaggcaa atgagacaat tgtttcatca catttttttg 13440tctattcaaa
aggaatatat tatgatgggc tacttgtgtc ccaatcactc aagagcatcg
13500caagatgtgt attctggtca gagactatag ttgatgaaac aagggcagca
tgcagtaata 13560ttgctacaac aatggctaaa agcatcgaga gaggttatga
ccgttacctt gcatattccc 13620tgaacgtcct aaaagtgata cagcaaattc
tgatctctct tggcttcaca atcaattcaa 13680ccatgacccg ggatgtagtc
atacccctcc tcacaaacaa cgacctctta ataaggatgg 13740cactgttgcc
cgctcctatt ggggggatga attatctgaa tatgagcagg ctgtttgtca
13800gaaacatcgg tgatccagta acatcatcaa ttgctgatct caagagaatg
attctcgcct 13860cactaatgcc tgaagagacc ctccatcaag taatgacaca
acaaccgggg gactcttcat 13920tcctagactg ggctagcgac ccttactcag
caaatcttgt atgtgtccag agcatcacta 13980gactcctcaa gaacataact
gcaaggtttg tcctgatcca tagtccaaac ccaatgttaa 14040aaggattatt
ccatgatgac agtaaagaag aggacgaggg actggcggca ttcctcatgg
14100acaggcatat tatagtacct agggcagctc atgaaatcct ggatcatagt
gtcacagggg 14160caagagagtc tattgcaggc atgctggata ccacaaaagg
cttgattcga gccagcatga 14220ggaagggggg gttaacctct cgagtgataa
ccagattgtc caattatgac tatgaacaat 14280tcagagcagg gatggtgcta
ttgacaggaa gaaagagaaa tgtcctcatt gacaaagagt 14340catgttcagt
gcagctggcg agagctctaa gaagccatat gtgggcgagg ctagctcgag
14400gacggcctat ttacggcctt gaggtccctg atgtactaga atctatgcga
ggccacctta 14460ttcggcgtca tgagacatgt gtcatctgcg agtgtggatc
agtcaactac ggatggtttt 14520ttgtcccctc gggttgccaa ctggatgata
ttgacaagga aacatcatcc ttgagagtcc 14580catatattgg ttctaccact
gatgagagaa cagacatgaa gcttgccttc gtaagagccc 14640caagtcgatc
cttgcgatct gctgttagaa tagcaacagt gtactcatgg gcttacggtg
14700atgatgatag ctcttggaac gaagcctggt tgttggctag gcaaagggcc
aatgtgagcc 14760tggaggagct aagggtgatc actcccatct caacttcgac
taatttagcg cataggttga 14820gggatcgtag cactcaagtg aaatactcag
gtacatccct tgtccgagtg gcgaggtata 14880ccacaatctc caacgacaat
ctctcatttg tcatatcaga taagaaggtt gatactaact 14940ttatatacca
acaaggaatg cttctagggt tgggtgtttt agaaacattg tttcgactcg
15000agaaagatac cggatcatct aacacggtat tacatcttca cgtcgaaaca
gattgttgcg 15060tgatcccgat gatagatcat cccaggatac ccagctcccg
caagctagag ctgagggcag 15120agctatgtac caacccattg atatatgata
atgcaccttt aattgacaga gatgcaacaa 15180ggctatacac ccagagccat
aggaggcacc ttgtggaatt tgttacatgg tccacacccc 15240aactatatca
cattttagct aagtccacag cactatctat gattgacctg gtaacaaaat
15300ttgagaagga ccatatgaat gaaatttcag ctctcatagg ggatgacgat
atcaatagtt 15360tcataactga gtttctgctc atagagccaa gattattcac
tatctacttg ggccagtgtg 15420cggccatcaa ttgggcattt gatgtacatt
atcatagacc atcagggaaa tatcagatgg 15480gtgagctgtt gtcatcgttc
ctttctagaa tgagcaaagg agtgtttaag gtgcttgtca 15540atgctctaag
ccacccaaag atctacaaga aattctggca ttgtggtatt atagagccta
15600tccatggtcc ttcacttgat gctcaaaact tgcacacaac tgtgtgcaac
atggtttaca 15660catgctatat gacctacctc gacctgttgt tgaatgaaga
gttagaagag ttcacatttc 15720tcttgtgtga aagcgacgag gatgtagtac
cggacagatt cgacaacatc caggcaaaac 15780acttatgtgt tctggcagat
ttgtactgtc aaccagggac ctgcccacca attcgaggtc 15840taagaccggt
agagaaatgt gcagttctaa ccgaccatat caaggcagag gctatgttat
15900ctccagcagg atcttcgtgg aacataaatc caattattgt agaccattac
tcatgctctc 15960tgacttatct ccggcgagga tcgatcaaac agataagatt
gagagttgat ccaggattca 16020ttttcgacgc cctcgctgag gtaaatgtca
gtcagccaaa gatcggcagc aacaacatct 16080caaatatgag catcaaggct
ttcagacccc cacacgatga tgttgcaaaa ttgctcaaag 16140atatcaacac
aagcaagcac aatcttccca tttcaggggg caatctcgcc aattatgaaa
16200tccatgcttt ccgcagaatc gggttgaact catctgcttg ctacaaagct
gttgagatat 16260caacattaat taggagatgc cttgagccag gggaggacgg
cttgttcttg ggtgagggat 16320cgggttctat gttgatcact tataaagaga
tacttaaact aaacaagtgc ttctataata 16380gtggggtttc cgccaattct
agatctggtc aaagggaatt agcaccctat ccctccgaag 16440ttggccttgt
cgaacacaga atgggagtag gtaatattgt caaagtgctc tttaacggga
16500ggcccgaagt cacgtgggta ggcagtgtag attgcttcaa tttcatagtt
agtaatatcc 16560ctacctctag tgtggggttt atccattcag atatagagac
cttgcctgac aaagatacta 16620tagagaagct agaggaattg gcagccatct
tatcgatggc tctgctcctg ggcaaaatag 16680gatcaatact ggtgattaag
cttatgcctt tcagcgggga ttttgttcag ggatttataa 16740gttatgtagg
gtctcattat agagaagtga accttgtata ccctagatac agcaacttca
16800tctctactga atcttatttg gttatgacag atctcaaggc taaccggcta
atgaatcctg 16860aaaagattaa gcagcagata attgaatcat ctgtgaggac
ttcacctgga cttataggtc 16920acatcctatc cattaagcaa ctaagctgca
tacaagcaat tgtgggagac gcagttagta 16980gaggtgatat caatcctact
ctgaaaaaac ttacacctat agagcaggtg ctgatcaatt 17040gcgggttggc
aattaacgga cctaagctgt gcaaagaatt gatccaccat gatgttgcct
17100cagggcaaga tggattgctt aattctatac tcatcctcta cagggagttg
gcaagattca 17160aagacaacca aagaagtcaa caagggatgt tccacgctta
ccccgtattg gtaagtagca 17220ggcaacgaga acttatatct aggatcaccc
gcaaattctg ggggcacatt cttctttact 17280ccgggaacaa aaagttgata
aataagttta tccagaatct caagtccggc tatctgatac 17340tagacttaca
ccagaatatc ttcgttaaga atctatccaa gtcagagaaa cagattatta
17400tgacgggggg tttgaaacgt gagtgggttt ttaaggtaac agtcaaggag
accaaagaat 17460ggtataagtt agtcggatac agtgccctga ttaaggacta
attggttgaa ctccggaacc 17520ctaatcctgc cctaggtggt taggcattat
ttgcaatata ttaaagaaaa ctttgaaaat 17580acgaagtttc tattcccagc
tttgtctggt 17610517570DNAArtificialartificial MV genome
MeVac_P-FhIL-12 5accaaacaaa gttgggtaag gatagttcaa tcaatgatca
tcttctagtg cacttaggat 60tcaagatcct attatcaggg acaagagcag gattagggat
atccgagatg gccacacttt 120taaggagctt agcattgttc aaaagaaaca
aggacaaacc acccattaca tcaggatccg 180gtggagccat cagaggaatc
aaacacatta ttatagtacc aatccctgga gattcctcaa 240ttaccactcg
atccagactt ctggaccggt tggtgaggtt aattggaaac ccggatgtga
300gcgggcccaa actaacaggg gcactaatag gtatattatc cttatttgtg
gagtctccag 360gtcaattgat tcagaggatc accgatgacc ctgacgttag
cataaggctg ttagaggttg 420tccagagtga ccagtcacaa tctggcctta
ccttcgcatc aagaggtacc aacatggagg 480atgaggcgga ccaatacttt
tcacatgatg atccaattag tagtgatcaa tccaggttcg 540gatggttcgg
gaacaaggaa atctcagata ttgaagtgca agaccctgag ggattcaaca
600tgattctggg taccatccta gcccaaattt gggtcttgct cgcaaaggcg
gttacggccc 660cagacacggc agctgattcg gagctaagaa ggtggataaa
gtacacccaa caaagaaggg 720tagttggtga atttagattg gagagaaaat
ggttggatgt ggtgaggaac aggattgccg 780aggacctctc cttacgccga
ttcatggtcg ctctaatcct ggatatcaag agaacacccg 840gaaacaaacc
caggattgct gaaatgatat gtgacattga tacatatatc gtagaggcag
900gattagccag ttttatcctg actattaagt ttgggataga aactatgtat
cctgctcttg 960gactgcatga atttgctggt gagttatcca cacttgagtc
cttgatgaac ctttaccagc 1020aaatggggga aactgcaccc tacatggtaa
tcctggagaa ctcaattcag aacaagttca 1080gtgcaggatc ataccctctg
ctctggagct atgccatggg agtaggagtg gaacttgaaa 1140actccatggg
aggtttgaac tttggccgat cttactttga tccagcatat tttagattag
1200ggcaagagat ggtaaggagg tcagctggaa aggtcagttc cacattggca
tctgaactcg 1260gtatcactgc cgaggatgca aggcttgttt cagagattgc
aatgcatact actgaggaca 1320agatcagtag agcggttgga cccagacaag
cccaagtatc atttctacac ggtgatcaaa 1380gtgagaatga gctaccgaga
ttggggggca aggaagatag gagggtcaaa cagagtcgag 1440gagaagccag
ggagagctac agagaaaccg ggcccagcag agcaagtgat gcgagagctg
1500cccatcttcc aaccggcaca cccctagaca ttgacactgc aacggagtcc
agccaagatc 1560cgcaggacag tcgaaggtca gctgacgccc tgcttaggct
gcaagccatg gcaggaatct 1620cggaagaaca aggctcagac acggacaccc
ctatagtgta caatgacaga aatcttctag 1680actaggtgcg agaggccgag
ggccagaaca acatccgcct accatccatc attgttataa 1740aaaacttagg
aaccaggtcc acacagccgc cagcccatca accatccact cccacgattg
1800gagccaatgg cagaagagca ggcacgccat gtcaaaaacg gactggaatg
catccgggct 1860ctcaaggccg agcccatcgg ctcactggcc atcgaggaag
ctatggcagc atggtcagaa 1920atatcagaca acccaggaca ggagcgagcc
acctgcaggg aagagaaggc aggcagttcg 1980ggtctcagca aaccatgcct
ctcagcaatt ggatcaactg aaggcggtgc acctcgcatc 2040cgcggtcagg
gacctggaga gagcgatgac gacgctgaaa ctttgggaat ccccccaaga
2100aatctccagg catcaagcac tgggttacag tgttattacg tttatgatca
cagcggtgaa 2160gcggttaagg gaatccaaga tgctgactct atcatggttc
aatcaggcct tgatggtgat 2220agcaccctct caggaggaga caatgaatct
gaaaacagcg atgtggatat tggcgaacct 2280gataccgagg gatatgctat
cactgaccgg ggatctgctc ccatctctat ggggttcagg 2340gcttctgatg
ttgaaactgc agaaggaggg gagatccacg agctcctgag actccaatcc
2400agaggcaaca actttccgaa gcttgggaaa actctcaatg ttcctccgcc
cccggacccc 2460ggtagggcca gcacttccgg gacacccatt aaaaagggca
cagacgcgag attagcctca 2520tttggaacgg agatcgcgtc tttattgaca
ggtggtgcaa cccaatgtgc tcgaaagtca 2580ccctcggaac catcagggcc
aggtgcacct gcggggaatg tccccgagtg tgtgagcaat 2640gccgcactga
tacaggagtg gacacccgaa tctggtacca caatctcccc gagatcccag
2700aataatgaag aagggggaga ctattatgat gatgagctgt tctctgatgt
ccaagatatt 2760aaaacagcct tggccaaaat acacgaggat aatcagaaga
taatctccaa gctagaatca 2820ctgctgttat tgaagggaga agttgagtca
attaagaagc agatcaacag gcaaaatatc 2880agcatatcca ccctggaagg
acacctctca agcatcatga tcgccattcc tggacttggg 2940aaggatccca
acgaccccac tgcagatgtc gaaatcaatc ccgacttgaa acccatcata
3000ggcagagatt caggccgagc actggccgaa gttctcaaga aacccgttgc
cagccgacaa 3060ctccaaggaa tgacaaatgg acggaccagt tccagaggac
agctgctgaa ggaatttcag 3120ctaaagccga tcgggaaaaa gatgagctca
gccgtcgggt ttgttcctga caccggccct 3180gcatcacgca gtgtaatccg
ctccattata aaatccagcc ggctagagga ggatcggaag 3240cgttacctga
tgactctcct tgatgatatc aaaggagcca atgatcttgc caagttccac
3300cagatgctga tgaagataat aatgaagtag ctacagctca acttacctgc
caaccccatg 3360ccagtcgacc caactagcaa cctaaatcca ttataaaaaa
cttaggaacc aggtccacac 3420agctcgagtc gcgcgtgcca ccatgtgtca
ccagcagttg gtcatctctt ggttttccct 3480ggtttttctg gcatctcccc
tcgtggccat atgggaactg aagaaagatg tttatgtcgt 3540agaattggat
tggtatccgg atgcccctgg agaaatggtg gtcctcacct gtgacacccc
3600tgaagaagat ggtatcacct ggaccttgga ccagagcagt gaggtcttag
gctctggcaa 3660aaccctgacc atccaagtca aagagtttgg agatgctggc
cagtacacct gtcacaaagg 3720aggcgaggtt ctaagccatt cgctcctgct
gcttcacaaa aaggaagatg gaatttggtc 3780cactgatatt ttaaaggacc
agaaagaacc caaaaataag acctttctaa gatgcgaggc 3840caagaattat
tctggacgtt tcacctgctg gtggctgacg acaatcagta ctgatttgac
3900attcagtgtc aaaagcagca gaggctcttc tgacccccaa ggggtgacgt
gcggagctgc 3960tacactctct gcagagagag tcagagggga caacaaggag
tatgagtact cagtggagtg 4020ccaggaggac agtgcctgcc cagctgctga
ggagagtctg cccattgagg tcatggtgga 4080tgccgttcac aagctcaagt
atgaaaacta caccagcagc ttcttcatca gggacatcat 4140caaacctgac
ccacccaaga acttgcagct gaagccatta aagaattctc ggcaggtgga
4200ggtcagctgg gagtaccctg acacctggag tactccacat tcctacttct
ccctgacatt 4260ctgcgttcag gtccagggca agagcaagag agaaaagaaa
gatagagtct tcaccgacaa 4320gacctcagcc acggtcatct gccgcaaaaa
tgccagcatt agcgtgcggg cccaggaccg 4380ctactatagc tcatcttgga
gcgaatgggc atctgtgccc tgcagtggtg gcggtggcgg 4440cggatctaga
aacctccccg tggccactcc agacccagga atgttcccat gccttcacca
4500ctcccaaaac ctgctgaggg ccgtcagcaa catgctccag aaggccagac
aaactctaga 4560attttaccct tgcacttctg aagagattga tcatgaagat
atcacaaaag ataaaaccag 4620cacagtggag gcctgtttac cattggaatt
aaccaagaat gagagttgcc taaattccag 4680agagacctct ttcataacta
atgggagttg cctggcctcc agaaagacct cttttatgat 4740ggccctgtgc
cttagtagta tttatgaaga cttgaagatg taccaggtgg agttcaagac
4800catgaatgca aagcttctga tggatcctaa gaggcagatc tttctagatc
aaaacatgct 4860ggcagttatt gatgagctga tgcaggccct gaatttcaac
agtgagactg tgccacaaaa 4920atcctccctt gaagaaccgg atttttataa
aactaaaatc aagctctgca tacttcttca 4980tgctttcaga attcgggcag
tgactattga tagagtgatg agctatctga atgcttccta 5040ggcgcgcgtg
ctagtacaac ctaaatccat tataaaaaac ttaggagcaa agtgattgcc
5100tcccaaggtc cacaatgaca gagacctacg acttcgacaa gtcggcatgg
gacatcaaag 5160ggtcgatcgc tccgatacaa cccaccacct acagtgatgg
caggctggtg ccccaggtca 5220gagtcataga tcctggtcta ggcgacagga
aggatgaatg ctttatgtac atgtttctgc 5280tgggggttgt tgaggacagc
gattccctag ggcctccaat cgggcgagca tttgggttcc 5340tgcccttagg
tgttggcaga tccacagcaa agcccgaaaa actcctcaaa gaggccactg
5400agcttgacat agttgttaga cgtacagcag ggctcaatga aaaactggtg
ttctacaaca 5460acaccccact aactctcctc acaccttgga gaaaggtcct
aacaacaggg agtgtcttca 5520acgcaaacca agtgtgcaat gcggttaatc
tgataccgct cgataccccg cagaggttcc 5580gtgttgttta tatgagcatc
acccgtcttt cggataacgg gtattacacc gttcctagaa 5640gaatgctgga
attcagatcg gtcaatgcag tggccttcaa cctgctggtg acccttagga
5700ttgacaaggc gataggccct gggaagatca tcgacaatac agagcaactt
cctgaggcaa 5760catttatggt ccacatcggg aacttcagga gaaagaagag
tgaagtctac tctgccgatt 5820attgcaaaat gaaaatcgaa aagatgggcc
tggtttttgc acttggtggg atagggggca 5880ccagtcttca cattagaagc
acaggcaaaa tgagcaagac tctccatgca caactcgggt 5940tcaagaagac
cttatgttac ccgctgatgg atatcaatga agaccttaat cgattactct
6000ggaggagcag atgcaagata gtaagaatcc aggcagtttt gcagccatca
gttcctcaag 6060aattccgcat ttacgacgac gtgatcataa atgatgacca
aggactattc aaagttctgt 6120agaccgtagt gcccagcaat gcccgaaaac
gacccccctc acaatgacag ccagaaggcc 6180cggacaaaaa agccccctcc
gaaagactcc acggaccaag cgagaggcca gccagcagcc 6240gacggcaagc
gcgaacacca ggcggcccca gcacagaaca gccctgacac aaggccacca
6300ccagccaccc caatctgcat cctcctcgtg ggacccccga ggaccaaccc
ccaaggctgc 6360ccccgatcca aaccaccaac cgcatcccca ccacccccgg
gaaagaaacc cccagcaatt 6420ggaaggcccc tccccctctt cctcaacaca
agaactccac aaccgaaccg cacaagcgac 6480cgaggtgacc caaccgcagg
catccgactc cctagacaga tcctctctcc ccggcaaact 6540aaacaaaact
tagggccaag gaacatacac acccaacaga acccagaccc cggcccacgg
6600cgccgcgccc ccaacccccg acaaccagag ggagccccca accaatcccg
ccggctcccc 6660cggtgcccac aggcagggac accaaccccc gaacagaccc
agcacccaac catcgacaat 6720ccaagacggg ggggcccccc caaaaaaagg
cccccagggg ccgacagcca gcaccgcgag 6780gaagcccacc caccccacac
acgaccacgg caaccaaacc agaacccaga ccaccctggg 6840ccaccagctc
ccagactcgg ccatcacccc gcagaaagga aaggccacaa cccgcgcacc
6900ccagccccga tccggcgggg agccacccaa cccgaaccag cacccaagag
cgatccccga 6960aggacccccg aaccgcaaag gacatcagta tcccacagcc
tctccaagtc ccccggtctc 7020ctcctcttct cgaagggacc aaaagatcaa
tccaccacac ccgacgacac tcaactcccc 7080acccctaaag gagacaccgg
gaatcccaga atcaagactc atccaatgtc catcatgggt 7140ctcaaggtga
acgtctctgc catattcatg gcagtactgt taactctcca aacacccacc
7200ggtcaaatcc attggggcaa tctctctaag ataggggtgg taggaatagg
aagtgcaagc 7260tacaaagtta tgactcgttc cagccatcaa tcattagtca
taaaattaat gcccaatata 7320actctcctca ataactgcac gagggtagag
attgcagaat acaggagact actgagaaca 7380gttttggaac caattagaga
tgcacttaat gcaatgaccc agaatataag accggttcag 7440agtgtagctt
caagtaggag acacaagaga tttgcgggag tagtcctggc aggtgcggcc
7500ctaggcgttg ccacagctgc tcagataaca gccggcattg cacttcacca
gtccatgctg 7560aactctcaag
ccatcgacaa tctgagagcg agcctggaaa ctactaatca ggcaattgag
7620acaatcagac aagcagggca ggagatgata ttggctgttc agggtgtcca
agactacatc 7680aataatgagc tgataccgtc tatgaaccaa ctatcttgtg
atttaatcgg ccagaagctc 7740gggctcaaat tgctcagata ctatacagaa
atcctgtcat tatttggccc cagtttacgg 7800gaccccatat ctgcggagat
atctatccag gctttgagct atgcgcttgg aggagacatc 7860aataaggtgt
tagaaaagct cggatacagt ggaggtgatt tactgggcat cttagagagc
7920ggaggaataa aggcccggat aactcacgtc gacacagagt cctacttcat
tgtcctcagt 7980atagcctatc cgacgctgtc cgagattaag ggggtgattg
tccaccggct agagggggtc 8040tcgtacaaca taggctctca agagtggtat
accactgtgc ccaagtatgt tgcaacccaa 8100gggtacctta tctcgaattt
tgatgagtca tcgtgtactt tcatgccaga ggggactgtg 8160tgcagccaaa
atgccttgta cccgatgagt cctctgctcc aagaatgcct ccgggggtac
8220accaagtcct gtgctcgtac actcgtatcc gggtcttttg ggaaccggtt
cattttatca 8280caagggaacc taatagccaa ttgtgcatca atcctttgca
agtgttacac aacaggaacg 8340atcattaatc aagaccctga caagatccta
acatacattg ctgccgatca ctgcccggta 8400gtcgaggtga acggcgtgac
catccaagtc gggagcagga ggtatccaga cgctgtgtac 8460ttgcacagaa
ttgacctcgg tcctcccata tcattggaga ggttggacgt agggacaaat
8520ctggggaatg caattgctaa gttggaggat gccaaggaat tgttggagtc
atcggaccag 8580atattgagga gtatgaaagg tttatcgagc actagcatag
tctacatcct gattgcagtg 8640tgtcttggag ggttgatagg gatccccgct
ttaatatgtt gctgcagggg gcgttgtaac 8700aaaaagggag aacaagttgg
tatgtcaaga ccaggcctaa agcctgatct tacgggaaca 8760tcaaaatcct
atgtaaggtc gctctgatcc tctacaactc ttgaaacaca aatgtcccac
8820aagtctcctc ttcgtcatca agcaaccacc gcacccagca tcaagcccac
ctgaaattat 8880ctccggcttc cctctggccg aacaatatcg gtagttaatc
aaaacttagg gtgcaagatc 8940atccacaatg tcaccacaac gagaccggat
aaatgccttc tacaaagata acccccatcc 9000caagggaagt aggatagtca
ttaacagaga acatcttatg attgatagac cttatgtttt 9060gctggctgtt
ctgtttgtca tgtttctgag cttgatcggg ttgctagcca ttgcaggcat
9120tagacttcat cgggcagcca tctacaccgc agagatccat aaaagcctca
gcaccaatct 9180agatgtaact aactcaatcg agcatcaggt caaggacgtg
ctgacaccac tcttcaaaat 9240catcggtgat gaagtgggcc tgaggacacc
tcagagattc actgacctag tgaaattaat 9300ctctgacaag attaaattcc
ttaatccgga tagggagtac gacttcagag atctcacttg 9360gtgtatcaac
ccgccagaga gaatcaaatt ggattatgat caatactgtg cagatgtggc
9420tgctgaagag ctcatgaatg cattggtgaa ctcaactcta ctggagacca
gaacaaccaa 9480tcagttccta gctgtctcaa agggaaactg ctcagggccc
actacaatca gaggtcaatt 9540ctcaaacatg tcgctgtccc tgttagactt
gtatttaggt cgaggttaca atgtgtcatc 9600tatagtcact atgacatccc
agggaatgta tgggggaact tacctagtgg aaaagcctaa 9660tctgagcagc
aaaaggtcag agttgtcaca actgagcatg taccgagtgt ttgaagtagg
9720tgttatcaga aatccgggtt tgggggctcc ggtgttccat atgacaaact
atcttgagca 9780accagtcagt aatgatctca gcaactgtat ggtggctttg
ggggagctca aactcgcagc 9840cctttgtcac ggggaagatt ctatcacaat
tccctatcag ggatcaggga aaggtgtcag 9900cttccagctc gtcaagctag
gtgtctggaa atccccaacc gacatgcaat cctgggtccc 9960cttatcaacg
gatgatccag tgatagacag gctttacctc tcatctcaca gaggtgttat
10020cgctgacaat caagcaaaat gggctgtccc gacaacacga acagatgaca
agttgcgaat 10080ggagacatgc ttccaacagg cgtgtaaggg taaaatccaa
gcactctgcg agaatcccga 10140gtgggcacca ttgaaggata acaggattcc
ttcatacggg gtcttgtctg ttgatctgag 10200tctgacagtt gagcttaaaa
tcaaaattgc ttcgggattc gggccattga tcacacacgg 10260ttcagggatg
gacctataca aatccaacca caacaatgtg tattggctga ctatcccgcc
10320aatgaagaac ctagccttag gtgtaatcaa cacattggag tggataccga
gattcaaggt 10380tagtccctac ctcttcactg tcccaattaa ggaagcaggc
gaagactgcc atgccccaac 10440atacctacct gcggaggtgg atggtgatgt
caaactcagt tccaatctgg tgattctacc 10500tggtcaagat ctccaatatg
ttttggcaac ctacgatact tccagggttg aacatgctgt 10560ggtttattac
gtttacagcc caagccgctc attttcttac ttttatcctt ttaggttgcc
10620tataaagggg gtccccatcg aattacaagt ggaatgcttc acatgggacc
aaaaactctg 10680gtgccgtcac ttctgtgtgc ttgcggactc agaatctggt
ggacatatca ctcactctgg 10740gatggtgggc atgggagtca gctgcacagt
cacccgggaa gatggaacca atcgcagata 10800gggctgctag tgaaccaatc
acatgatgtc acccagacat caggcatacc cactagtgtg 10860aaatagacat
cagaattaag aaaaacgtag ggtccaagtg gttccccgtt atggactcgc
10920tatctgtcaa ccagatctta taccctgaag ttcacctaga tagcccgata
gttaccaata 10980agatagtagc catcctggag tatgctcgag tccctcacgc
ttacagcctg gaggacccta 11040cactgtgtca gaacatcaag caccgcctaa
aaaacggatt ttccaaccaa atgattataa 11100acaatgtgga agttgggaat
gtcatcaagt ccaagcttag gagttatccg gcccactctc 11160atattccata
tccaaattgt aatcaggatt tatttaacat agaagacaaa gagtcaacga
11220ggaagatccg tgaactcctc aaaaagggga attcgctgta ctccaaagtc
agtgataagg 11280ttttccaatg cttaagggac actaactcac ggcttggcct
aggctccgaa ttgagggagg 11340acatcaagga gaaagttatt aacttgggag
tttacatgca cagctcccag tggtttgagc 11400cctttctgtt ttggtttaca
gtcaagactg agatgaggtc agtgattaaa tcacaaaccc 11460atacttgcca
taggaggaga cacacacctg tattcttcac tggtagttca gttgagttgc
11520taatctctcg tgaccttgtt gctataatca gtaaagagtc tcaacatgta
tattacctga 11580catttgaact ggttttgatg tattgtgatg tcatagaggg
gaggttaatg acagagaccg 11640ctatgactat tgatgctagg tatacagagc
ttctaggaag agtcagatac atgtggaaac 11700tgatagatgg tttcttccct
gcactcggga atccaactta tcaaattgta gccatgctgg 11760agcctctttc
acttgcttac ctgcagctga gggatataac agtagaactc agaggtgctt
11820tccttaacca ctgctttact gaaatacatg atgttcttga ccaaaacggg
ttttctgatg 11880aaggtactta tcatgagtta actgaagctc tagattacat
tttcataact gatgacatac 11940atctgacagg ggagattttc tcatttttca
gaagtttcgg ccaccccaga cttgaagcag 12000taacggctgc tgaaaatgtt
aggaaataca tgaatcagcc taaagtcatt gtgtatgaga 12060ctctgatgaa
aggtcatgcc atattttgtg gaatcataat caacggctat cgtgacaggc
12120acggaggcag ttggccaccg ctgaccctcc ccctgcatgc tgcagacaca
atccggaatg 12180ctcaagcttc aggtgaaggg ttaacacatg agcagtgcgt
tgataactgg aaatcttttg 12240ctggagtgaa atttggctgc tttatgcctc
ttagcctgga tagtgatctg acaatgtacc 12300taaaggacaa ggcacttgct
gctctccaaa gggaatggga ttcagtttac ccgaaagagt 12360tcctgcgtta
cgaccctccc aagggaaccg ggtcacggag gcttgtagat gttttcctta
12420atgattcgag ctttgaccca tatgatgtga taatgtatgt tgtaagtgga
gcttacctcc 12480atgaccctga gttcaacctg tcttacagcc tgaaagaaaa
ggagatcaag gaaacaggta 12540gactttttgc taaaatgact tacaaaatga
gggcatgcca agtgattgct gaaaatctaa 12600tctcaaacgg gattggcaaa
tattttaagg acaatgggat ggccaaggat gagcacgatt 12660tgactaaggc
actccacact ctagctgtct caggagtccc caaagatctc aaagaaagtc
12720acaggggggg gccagtctta aaaacctact cccgaagccc agtccacaca
agtaccagga 12780acgtgagagc agcaaaaggg tttatagggt tccctcaagt
aattcggcag gaccaagaca 12840ctgatcatcc ggagaatatg gaagcttacg
agacagtcag tgcatttatc acgactgatc 12900tcaagaagta ctgccttaat
tggagatatg agaccatcag cttgtttgca cagaggctaa 12960atgagattta
cggattgccc tcatttttcc agtggctgca taagaggctt gagacctctg
13020tcctgtatgt aagtgaccct cattgccccc ccgaccttga cgcccatatc
ccgttatata 13080aagtccccaa tgatcaaatc ttcattaagt accctatggg
aggtatagaa gggtattgtc 13140agaagctgtg gaccatcagc accattccct
atctatacct ggctgcttat gagagcggag 13200taaggattgc ttcgttagtg
caaggggaca atcagaccat agccgtaaca aaaagggtac 13260ccagcacatg
gccctacaac cttaagaaac gggaagctgc tagagtaact agagattact
13320ttgtaattct taggcaaagg ctacatgata ttggccatca cctcaaggca
aatgagacaa 13380ttgtttcatc acattttttt gtctattcaa aaggaatata
ttatgatggg ctacttgtgt 13440cccaatcact caagagcatc gcaagatgtg
tattctggtc agagactata gttgatgaaa 13500caagggcagc atgcagtaat
attgctacaa caatggctaa aagcatcgag agaggttatg 13560accgttacct
tgcatattcc ctgaacgtcc taaaagtgat acagcaaatt ctgatctctc
13620ttggcttcac aatcaattca accatgaccc gggatgtagt catacccctc
ctcacaaaca 13680acgacctctt aataaggatg gcactgttgc ccgctcctat
tggggggatg aattatctga 13740atatgagcag gctgtttgtc agaaacatcg
gtgatccagt aacatcatca attgctgatc 13800tcaagagaat gattctcgcc
tcactaatgc ctgaagagac cctccatcaa gtaatgacac 13860aacaaccggg
ggactcttca ttcctagact gggctagcga cccttactca gcaaatcttg
13920tatgtgtcca gagcatcact agactcctca agaacataac tgcaaggttt
gtcctgatcc 13980atagtccaaa cccaatgtta aaaggattat tccatgatga
cagtaaagaa gaggacgagg 14040gactggcggc attcctcatg gacaggcata
ttatagtacc tagggcagct catgaaatcc 14100tggatcatag tgtcacaggg
gcaagagagt ctattgcagg catgctggat accacaaaag 14160gcttgattcg
agccagcatg aggaaggggg ggttaacctc tcgagtgata accagattgt
14220ccaattatga ctatgaacaa ttcagagcag ggatggtgct attgacagga
agaaagagaa 14280atgtcctcat tgacaaagag tcatgttcag tgcagctggc
gagagctcta agaagccata 14340tgtgggcgag gctagctcga ggacggccta
tttacggcct tgaggtccct gatgtactag 14400aatctatgcg aggccacctt
attcggcgtc atgagacatg tgtcatctgc gagtgtggat 14460cagtcaacta
cggatggttt tttgtcccct cgggttgcca actggatgat attgacaagg
14520aaacatcatc cttgagagtc ccatatattg gttctaccac tgatgagaga
acagacatga 14580agcttgcctt cgtaagagcc ccaagtcgat ccttgcgatc
tgctgttaga atagcaacag 14640tgtactcatg ggcttacggt gatgatgata
gctcttggaa cgaagcctgg ttgttggcta 14700ggcaaagggc caatgtgagc
ctggaggagc taagggtgat cactcccatc tcaacttcga 14760ctaatttagc
gcataggttg agggatcgta gcactcaagt gaaatactca ggtacatccc
14820ttgtccgagt ggcgaggtat accacaatct ccaacgacaa tctctcattt
gtcatatcag 14880ataagaaggt tgatactaac tttatatacc aacaaggaat
gcttctaggg ttgggtgttt 14940tagaaacatt gtttcgactc gagaaagata
ccggatcatc taacacggta ttacatcttc 15000acgtcgaaac agattgttgc
gtgatcccga tgatagatca tcccaggata cccagctccc 15060gcaagctaga
gctgagggca gagctatgta ccaacccatt gatatatgat aatgcacctt
15120taattgacag agatgcaaca aggctataca cccagagcca taggaggcac
cttgtggaat 15180ttgttacatg gtccacaccc caactatatc acattttagc
taagtccaca gcactatcta 15240tgattgacct ggtaacaaaa tttgagaagg
accatatgaa tgaaatttca gctctcatag 15300gggatgacga tatcaatagt
ttcataactg agtttctgct catagagcca agattattca 15360ctatctactt
gggccagtgt gcggccatca attgggcatt tgatgtacat tatcatagac
15420catcagggaa atatcagatg ggtgagctgt tgtcatcgtt cctttctaga
atgagcaaag 15480gagtgtttaa ggtgcttgtc aatgctctaa gccacccaaa
gatctacaag aaattctggc 15540attgtggtat tatagagcct atccatggtc
cttcacttga tgctcaaaac ttgcacacaa 15600ctgtgtgcaa catggtttac
acatgctata tgacctacct cgacctgttg ttgaatgaag 15660agttagaaga
gttcacattt ctcttgtgtg aaagcgacga ggatgtagta ccggacagat
15720tcgacaacat ccaggcaaaa cacttatgtg ttctggcaga tttgtactgt
caaccaggga 15780cctgcccacc aattcgaggt ctaagaccgg tagagaaatg
tgcagttcta accgaccata 15840tcaaggcaga ggctatgtta tctccagcag
gatcttcgtg gaacataaat ccaattattg 15900tagaccatta ctcatgctct
ctgacttatc tccggcgagg atcgatcaaa cagataagat 15960tgagagttga
tccaggattc attttcgacg ccctcgctga ggtaaatgtc agtcagccaa
16020agatcggcag caacaacatc tcaaatatga gcatcaaggc tttcagaccc
ccacacgatg 16080atgttgcaaa attgctcaaa gatatcaaca caagcaagca
caatcttccc atttcagggg 16140gcaatctcgc caattatgaa atccatgctt
tccgcagaat cgggttgaac tcatctgctt 16200gctacaaagc tgttgagata
tcaacattaa ttaggagatg ccttgagcca ggggaggacg 16260gcttgttctt
gggtgaggga tcgggttcta tgttgatcac ttataaagag atacttaaac
16320taaacaagtg cttctataat agtggggttt ccgccaattc tagatctggt
caaagggaat 16380tagcacccta tccctccgaa gttggccttg tcgaacacag
aatgggagta ggtaatattg 16440tcaaagtgct ctttaacggg aggcccgaag
tcacgtgggt aggcagtgta gattgcttca 16500atttcatagt tagtaatatc
cctacctcta gtgtggggtt tatccattca gatatagaga 16560ccttgcctga
caaagatact atagagaagc tagaggaatt ggcagccatc ttatcgatgg
16620ctctgctcct gggcaaaata ggatcaatac tggtgattaa gcttatgcct
ttcagcgggg 16680attttgttca gggatttata agttatgtag ggtctcatta
tagagaagtg aaccttgtat 16740accctagata cagcaacttc atctctactg
aatcttattt ggttatgaca gatctcaagg 16800ctaaccggct aatgaatcct
gaaaagatta agcagcagat aattgaatca tctgtgagga 16860cttcacctgg
acttataggt cacatcctat ccattaagca actaagctgc atacaagcaa
16920ttgtgggaga cgcagttagt agaggtgata tcaatcctac tctgaaaaaa
cttacaccta 16980tagagcaggt gctgatcaat tgcgggttgg caattaacgg
acctaagctg tgcaaagaat 17040tgatccacca tgatgttgcc tcagggcaag
atggattgct taattctata ctcatcctct 17100acagggagtt ggcaagattc
aaagacaacc aaagaagtca acaagggatg ttccacgctt 17160accccgtatt
ggtaagtagc aggcaacgag aacttatatc taggatcacc cgcaaattct
17220gggggcacat tcttctttac tccgggaaca aaaagttgat aaataagttt
atccagaatc 17280tcaagtccgg ctatctgata ctagacttac accagaatat
cttcgttaag aatctatcca 17340agtcagagaa acagattatt atgacggggg
gtttgaaacg tgagtgggtt tttaaggtaa 17400cagtcaagga gaccaaagaa
tggtataagt tagtcggata cagtgccctg attaaggact 17460aattggttga
actccggaac cctaatcctg ccctaggtgg ttaggcatta tttgcaatat
17520attaaagaaa actttgaaaa tacgaagttt ctattcccag ctttgtctgg
17570618400DNAArtificialrecombinant measles virus expressing fused
mouse IL-12 with MV H protein specifically targeting human CEA
antigen (MeVac P-FmIL-12 Hbl-antiCEA) 6accaaacaaa gttgggtaag
gatagttcaa tcaatgatca tcttctagtg cacttaggat 60tcaagatcct attatcaggg
acaagagcag gattagggat atccgagatg gccacacttt 120taaggagctt
agcattgttc aaaagaaaca aggacaaacc acccattaca tcaggatccg
180gtggagccat cagaggaatc aaacacatta ttatagtacc aatccctgga
gattcctcaa 240ttaccactcg atccagactt ctggaccggt tggtgaggtt
aattggaaac ccggatgtga 300gcgggcccaa actaacaggg gcactaatag
gtatattatc cttatttgtg gagtctccag 360gtcaattgat tcagaggatc
accgatgacc ctgacgttag cataaggctg ttagaggttg 420tccagagtga
ccagtcacaa tctggcctta ccttcgcatc aagaggtacc aacatggagg
480atgaggcgga ccaatacttt tcacatgatg atccaattag tagtgatcaa
tccaggttcg 540gatggttcgg gaacaaggaa atctcagata ttgaagtgca
agaccctgag ggattcaaca 600tgattctggg taccatccta gcccaaattt
gggtcttgct cgcaaaggcg gttacggccc 660cagacacggc agctgattcg
gagctaagaa ggtggataaa gtacacccaa caaagaaggg 720tagttggtga
atttagattg gagagaaaat ggttggatgt ggtgaggaac aggattgccg
780aggacctctc cttacgccga ttcatggtcg ctctaatcct ggatatcaag
agaacacccg 840gaaacaaacc caggattgct gaaatgatat gtgacattga
tacatatatc gtagaggcag 900gattagccag ttttatcctg actattaagt
ttgggataga aactatgtat cctgctcttg 960gactgcatga atttgctggt
gagttatcca cacttgagtc cttgatgaac ctttaccagc 1020aaatggggga
aactgcaccc tacatggtaa tcctggagaa ctcaattcag aacaagttca
1080gtgcaggatc ataccctctg ctctggagct atgccatggg agtaggagtg
gaacttgaaa 1140actccatggg aggtttgaac tttggccgat cttactttga
tccagcatat tttagattag 1200ggcaagagat ggtaaggagg tcagctggaa
aggtcagttc cacattggca tctgaactcg 1260gtatcactgc cgaggatgca
aggcttgttt cagagattgc aatgcatact actgaggaca 1320agatcagtag
agcggttgga cccagacaag cccaagtatc atttctacac ggtgatcaaa
1380gtgagaatga gctaccgaga ttggggggca aggaagatag gagggtcaaa
cagagtcgag 1440gagaagccag ggagagctac agagaaaccg ggcccagcag
agcaagtgat gcgagagctg 1500cccatcttcc aaccggcaca cccctagaca
ttgacactgc aacggagtcc agccaagatc 1560cgcaggacag tcgaaggtca
gctgacgccc tgcttaggct gcaagccatg gcaggaatct 1620cggaagaaca
aggctcagac acggacaccc ctatagtgta caatgacaga aatcttctag
1680actaggtgcg agaggccgag ggccagaaca acatccgcct accatccatc
attgttataa 1740aaaacttagg aaccaggtcc acacagccgc cagcccatca
accatccact cccacgattg 1800gagccaatgg cagaagagca ggcacgccat
gtcaaaaacg gactggaatg catccgggct 1860ctcaaggccg agcccatcgg
ctcactggcc atcgaggaag ctatggcagc atggtcagaa 1920atatcagaca
acccaggaca ggagcgagcc acctgcaggg aagagaaggc aggcagttcg
1980ggtctcagca aaccatgcct ctcagcaatt ggatcaactg aaggcggtgc
acctcgcatc 2040cgcggtcagg gacctggaga gagcgatgac gacgctgaaa
ctttgggaat ccccccaaga 2100aatctccagg catcaagcac tgggttacag
tgttattacg tttatgatca cagcggtgaa 2160gcggttaagg gaatccaaga
tgctgactct atcatggttc aatcaggcct tgatggtgat 2220agcaccctct
caggaggaga caatgaatct gaaaacagcg atgtggatat tggcgaacct
2280gataccgagg gatatgctat cactgaccgg ggatctgctc ccatctctat
ggggttcagg 2340gcttctgatg ttgaaactgc agaaggaggg gagatccacg
agctcctgag actccaatcc 2400agaggcaaca actttccgaa gcttgggaaa
actctcaatg ttcctccgcc cccggacccc 2460ggtagggcca gcacttccgg
gacacccatt aaaaagggca cagacgcgag attagcctca 2520tttggaacgg
agatcgcgtc tttattgaca ggtggtgcaa cccaatgtgc tcgaaagtca
2580ccctcggaac catcagggcc aggtgcacct gcggggaatg tccccgagtg
tgtgagcaat 2640gccgcactga tacaggagtg gacacccgaa tctggtacca
caatctcccc gagatcccag 2700aataatgaag aagggggaga ctattatgat
gatgagctgt tctctgatgt ccaagatatt 2760aaaacagcct tggccaaaat
acacgaggat aatcagaaga taatctccaa gctagaatca 2820ctgctgttat
tgaagggaga agttgagtca attaagaagc agatcaacag gcaaaatatc
2880agcatatcca ccctggaagg acacctctca agcatcatga tcgccattcc
tggacttggg 2940aaggatccca acgaccccac tgcagatgtc gaaatcaatc
ccgacttgaa acccatcata 3000ggcagagatt caggccgagc actggccgaa
gttctcaaga aacccgttgc cagccgacaa 3060ctccaaggaa tgacaaatgg
acggaccagt tccagaggac agctgctgaa ggaatttcag 3120ctaaagccga
tcgggaaaaa gatgagctca gccgtcgggt ttgttcctga caccggccct
3180gcatcacgca gtgtaatccg ctccattata aaatccagcc ggctagagga
ggatcggaag 3240cgttacctga tgactctcct tgatgatatc aaaggagcca
atgatcttgc caagttccac 3300cagatgctga tgaagataat aatgaagtag
ctacagctca acttacctgc caaccccatg 3360ccagtcgacc caactagcaa
cctaaatcca ttataaaaaa cttaggaacc aggtccacac 3420agctcgagtc
gcgcgtggcc accatgtgtc ctcagaagct aaccatctcc tggtttgcca
3480tcgttttgct ggtgtcccca ctcatggcca tgtgggagct ggagaaagac
gtttatgttg 3540tagaggtgga ctggactccc gatgcccctg gagaaacagt
gaacctcacc tgtgacacgc 3600ctgaagaaga tgacatcacc tggacctcag
accagagaca tggagtcata ggctctggaa 3660agaccctgac catcactgtc
aaagagtttc tagatgctgg ccagtacacc tgccacaaag 3720gaggcgagac
tctgagccac tcacatctgc tgctccacaa gaaggaaaat ggaatttggt
3780ccactgaaat tttaaaaaat ttcaaaaaca agactttcct gaagtgtgaa
gcaccaaatt 3840actccggacg gttcacgtgc tcatggctgg tgcaaagaaa
catggacttg aagttcaaca 3900tcaagagcag tagcagttcc cctgactctc
gggcagtgac atgtggaatg gcgtctctgt 3960ctgcagagaa ggtcacactg
gaccaaaggg actatgagaa gtattcagtg tcctgccagg 4020aggatgtcac
ctgcccaact gccgaggaga ccctgcccat tgaactggcg ttggaagcac
4080ggcagcagaa taaatatgag aactacagca ccagcttctt catcagggac
atcatcaaac 4140cagacccgcc caagaacttg cagatgaagc ctttgaagaa
ctcacaggtg gaggtcagct 4200gggagtaccc tgactcctgg agcactcccc
attcctactt ctccctcaag ttctttgttc 4260gaatccagcg caagaaagaa
aagatgaagg agacagagga ggggtgtaac cagaaaggtg 4320cgttcctcgt
agagaagaca tctaccgaag tccaatgcaa aggcgggaat gtctgcgtgc
4380aagctcagga tcgctattac aattcctcgt gcagcaagtg ggcatgtgtt
ccctgcaggg 4440tccgatccgg tggcggtggc tcgggcggtg gtgggtcggg
tggcggcgga tctagggtca 4500ttccagtctc tggacctgcc aggtgtctta
gccagtcccg aaacctgctg aagaccacag 4560atgacatggt gaagacggcc
agagaaaaac tgaaacatta ttcctgcact gctgaagaca 4620tcgatcatga
agacatcaca cgggaccaaa ccagcacatt gaagacctgt ttaccactgg
4680aactacacaa gaacgagagt tgcctggcta ctagagagac ttcttccaca
acaagaggga 4740gctgcctgcc cccacagaag acgtctttga tgatgaccct
gtgccttggt agcatctatg 4800aggacttgaa gatgtaccag acagagttcc
aggccatcaa cgcagcactt cagaatcaca 4860accatcagca gatcattcta
gacaagggca
tgctggtggc catcgatgag ctgatgcagt 4920ctctgaatca taatggcgag
actctgcgcc agaaacctcc tgtgggagaa gcagaccctt 4980acagagtgaa
aatgaagctc tgcatcctgc ttcacgcctt cagcacccgc gtcgtgacca
5040tcaacagggt gatgggctat ctgagctccg cctgataatc gcgcgcgtgc
tagtacaacc 5100taaatccatt ataaaaaact taggagcaaa gtgattgcct
cccaaggtcc acaatgacag 5160agacctacga cttcgacaag tcggcatggg
acatcaaagg gtcgatcgct ccgatacaac 5220ccaccaccta cagtgatggc
aggctggtgc cccaggtcag agtcatagat cctggtctag 5280gcgacaggaa
ggatgaatgc tttatgtaca tgtttctgct gggggttgtt gaggacagcg
5340attccctagg gcctccaatc gggcgagcat ttgggttcct gcccttaggt
gttggcagat 5400ccacagcaaa gcccgaaaaa ctcctcaaag aggccactga
gcttgacata gttgttagac 5460gtacagcagg gctcaatgaa aaactggtgt
tctacaacaa caccccacta actctcctca 5520caccttggag aaaggtccta
acaacaggga gtgtcttcaa cgcaaaccaa gtgtgcaatg 5580cggttaatct
gataccgctc gataccccgc agaggttccg tgttgtttat atgagcatca
5640cccgtctttc ggataacggg tattacaccg ttcctagaag aatgctggaa
ttcagatcgg 5700tcaatgcagt ggccttcaac ctgctggtga cccttaggat
tgacaaggcg ataggccctg 5760ggaagatcat cgacaataca gagcaacttc
ctgaggcaac atttatggtc cacatcggga 5820acttcaggag aaagaagagt
gaagtctact ctgccgatta ttgcaaaatg aaaatcgaaa 5880agatgggcct
ggtttttgca cttggtggga tagggggcac cagtcttcac attagaagca
5940caggcaaaat gagcaagact ctccatgcac aactcgggtt caagaagacc
ttatgttacc 6000cgctgatgga tatcaatgaa gaccttaatc gattactctg
gaggagcaga tgcaagatag 6060taagaatcca ggcagttttg cagccatcag
ttcctcaaga attccgcatt tacgacgacg 6120tgatcataaa tgatgaccaa
ggactattca aagttctgta gaccgtagtg cccagcaatg 6180cccgaaaacg
acccccctca caatgacagc cagaaggccc ggacaaaaaa gccccctccg
6240aaagactcca cggaccaagc gagaggccag ccagcagccg acggcaagcg
cgaacaccag 6300gcggccccag cacagaacag ccctgacaca aggccaccac
cagccacccc aatctgcatc 6360ctcctcgtgg gacccccgag gaccaacccc
caaggctgcc cccgatccaa accaccaacc 6420gcatccccac cacccccggg
aaagaaaccc ccagcaattg gaaggcccct ccccctcttc 6480ctcaacacaa
gaactccaca accgaaccgc acaagcgacc gaggtgaccc aaccgcaggc
6540atccgactcc ctagacagat cctctctccc cggcaaacta aacaaaactt
agggccaagg 6600aacatacaca cccaacagaa cccagacccc ggcccacggc
gccgcgcccc caacccccga 6660caaccagagg gagcccccaa ccaatcccgc
cggctccccc ggtgcccaca ggcagggaca 6720ccaacccccg aacagaccca
gcacccaacc atcgacaatc caagacgggg gggccccccc 6780aaaaaaaggc
ccccaggggc cgacagccag caccgcgagg aagcccaccc accccacaca
6840cgaccacggc aaccaaacca gaacccagac caccctgggc caccagctcc
cagactcggc 6900catcaccccg cagaaaggaa aggccacaac ccgcgcaccc
cagccccgat ccggcgggga 6960gccacccaac ccgaaccagc acccaagagc
gatccccgaa ggacccccga accgcaaagg 7020acatcagtat cccacagcct
ctccaagtcc cccggtctcc tcctcttctc gaagggacca 7080aaagatcaat
ccaccacacc cgacgacact caactcccca cccctaaagg agacaccggg
7140aatcccagaa tcaagactca tccaatgtcc atcatgggtc tcaaggtgaa
cgtctctgcc 7200atattcatgg cagtactgtt aactctccaa acacccaccg
gtcaaatcca ttggggcaat 7260ctctctaaga taggggtggt aggaatagga
agtgcaagct acaaagttat gactcgttcc 7320agccatcaat cattagtcat
aaaattaatg cccaatataa ctctcctcaa taactgcacg 7380agggtagaga
ttgcagaata caggagacta ctgagaacag ttttggaacc aattagagat
7440gcacttaatg caatgaccca gaatataaga ccggttcaga gtgtagcttc
aagtaggaga 7500cacaagagat ttgcgggagt agtcctggca ggtgcggccc
taggcgttgc cacagctgct 7560cagataacag ccggcattgc acttcaccag
tccatgctga actctcaagc catcgacaat 7620ctgagagcga gcctggaaac
tactaatcag gcaattgaga caatcagaca agcagggcag 7680gagatgatat
tggctgttca gggtgtccaa gactacatca ataatgagct gataccgtct
7740atgaaccaac tatcttgtga tttaatcggc cagaagctcg ggctcaaatt
gctcagatac 7800tatacagaaa tcctgtcatt atttggcccc agtttacggg
accccatatc tgcggagata 7860tctatccagg ctttgagcta tgcgcttgga
ggagacatca ataaggtgtt agaaaagctc 7920ggatacagtg gaggtgattt
actgggcatc ttagagagcg gaggaataaa ggcccggata 7980actcacgtcg
acacagagtc ctacttcatt gtcctcagta tagcctatcc gacgctgtcc
8040gagattaagg gggtgattgt ccaccggcta gagggggtct cgtacaacat
aggctctcaa 8100gagtggtata ccactgtgcc caagtatgtt gcaacccaag
ggtaccttat ctcgaatttt 8160gatgagtcat cgtgtacttt catgccagag
gggactgtgt gcagccaaaa tgccttgtac 8220ccgatgagtc ctctgctcca
agaatgcctc cgggggtaca ccaagtcctg tgctcgtaca 8280ctcgtatccg
ggtcttttgg gaaccggttc attttatcac aagggaacct aatagccaat
8340tgtgcatcaa tcctttgcaa gtgttacaca acaggaacga tcattaatca
agaccctgac 8400aagatcctaa catacattgc tgccgatcac tgcccggtag
tcgaggtgaa cggcgtgacc 8460atccaagtcg ggagcaggag gtatccagac
gctgtgtact tgcacagaat tgacctcggt 8520cctcccatat cattggagag
gttggacgta gggacaaatc tggggaatgc aattgctaag 8580ttggaggatg
ccaaggaatt gttggagtca tcggaccaga tattgaggag tatgaaaggt
8640ttatcgagca ctagcatagt ctacatcctg attgcagtgt gtcttggagg
gttgataggg 8700atccccgctt taatatgttg ctgcaggggg cgttgtaaca
aaaagggaga acaagttggt 8760atgtcaagac caggcctaaa gcctgatctt
acgggaacat caaaatccta tgtaaggtcg 8820ctctgatcct ctacaactct
tgaaacacaa atgtcccaca agtctcctct tcgtcatcaa 8880gcaaccaccg
cacccagcat caagcccacc tgaaattatc tccggcttcc ctctggccga
8940acaatatcgg tagttaatca aaacttaggg tgcaagatca tccacaatgt
caccacaacg 9000agaccggata aatgccttct acaaagataa cccccatccc
aagggaagta ggatagtcat 9060taacagagaa catcttatga ttgatagacc
ttatgttttg ctggctgttc tgtttgtcat 9120gtttctgagc ttgatcgggt
tgctagccat tgcaggcatt agacttcatc gggcagccat 9180ctacaccgca
gagatccata aaagcctcag caccaatcta gatgtaacta actcaatcga
9240gcatcaggtc aaggacgtgc tgacaccact cttcaaaatc atcggtgatg
aagtgggcct 9300gaggacacct cagagattca ctgacctagt gaaattaatc
tctgacaaga ttaaattcct 9360taatccggat agggagtacg acttcagaga
tctcacttgg tgtatcaacc cgccagagag 9420aatcaaattg gattatgatc
aatactgtgc agatgtggct gctgaagagc tcatgaatgc 9480attggtgaac
tcaactctac tggagaccag aacaaccaat cagttcctag ctgtctcaaa
9540gggaaactgc tcagggccca ctacaatcag aggtcaattc tcaaacatgt
cgctgtccct 9600gttagacttg tatttaggtc gaggttacaa tgtgtcatct
atagtcacta tgacatccca 9660gggaatgtat gggggaactt acctagtgga
aaagcctaat ctgagcagca aaaggtcaga 9720gttgtcacaa ctgagcatgt
accgagtgtt tgaagtaggt gttatcagaa atccgggttt 9780gggggctccg
gtgttccata tgacaaacta tcttgagcaa ccagtcagta atgatctcag
9840caactgtatg gtggctttgg gggagctcaa actcgcagcc ctttgtcacg
gggaagattc 9900tatcacaatt ccctatcagg gatcagggaa aggtgtcagc
ttccagctcg tcaagctagg 9960tgtctggaaa tccccaaccg acatgcaatc
ctgggtcccc ttatcaacgg atgatccagt 10020gatagacagg ctttacctct
catctcacag aggtgttatc gctgacaatc aagcaaaatg 10080ggctgtcccg
acaacacgaa cagatgacaa gttgcgaatg gagacatgct tccaacaggc
10140gtgtaagggt aaaatccaag cactctgcga gaatcccgag tgggcaccat
tgaaggataa 10200caggattcct tcatacgggg tcttgtctgt tgatctgagt
ctgacagttg agcttaaaat 10260caaaattgct tcgggattcg ggccattgat
cacacacggt tcagggatgg acctatacaa 10320atccaaccac aacaatgtgt
attggctgac tatcccgcca atgaagaacc tagccttagg 10380tgtaatcaac
acattggagt ggataccgag attcaaggtt agtcccgcac tcttcactgt
10440cccaattaag gaagcaggcg aagactgcca tgccccaaca tacctacctg
cggaggtgga 10500tggtgatgtc aaactcagtt ccaatctggt gattctacct
ggtcaagatc tccaatatgt 10560tttggcaacc tacgatactt ccgcggttga
acatgctgtg gtttattacg tttacagccc 10620aagccgccta tcgtcttact
tttatccttt taggttgcct ataaaggggg tccccatcga 10680attacaagtg
gaatgcttca catgggacca aaaactctgg tgccgtcact tctgtgtgct
10740tgcggactca gaatctggtg gacatatcac tcactctggg atggtgggca
tgggagtcag 10800ctgcacagtc acccgggaag atggaaccaa tgcggcccag
ccggccatcg agggaaggat 10860ggctcaggtg aaactgcagc agtctggggc
agaacttgtg aggtcaggga cctcagtcaa 10920gttgtcctgc acagcttctg
gcttcaacat taaagactcc tatatgcact ggttgaggca 10980ggggcctgaa
cagtgcctcg agtggattgg atggattgat cctgagaatg gtgatactga
11040atatgccccg aagttccagg gcaaggccac ttttactaca gacacatcct
ccaacacagc 11100ctacctgcag ctcagcagcc tgacatctga ggacactgcc
gtctattatt gtaatgaggg 11160gactccgact gggccgtact actttgacta
ctggggccaa gggaccacgg tcaccgtctc 11220ctcaggtgga ggcggttcag
gcggaggtgg ctctggcggt ggcggatcag aaaatgtgct 11280cacccagtct
ccagcaatca tgtctgcatc tccaggggag aaggtcacca taacctgcag
11340tgccagctca agtgtaagtt acatgcactg gttccagcag aagccaggca
cttctcccaa 11400actctggatt tatagcacat ccaacctggc ttctggagtc
cctgctcgct tcagtggcag 11460tggatctggg acctcttact ctctcacaat
cagccgaatg gaggctgaag atgctgccac 11520ttattactgc cagcaaagga
gtagttaccc actcacgttc ggttgtggca ccaagctcga 11580gctgaaacgg
gcggccgcaa gaggttctca tcaccatcac catcactaat agggctgcta
11640gtgaaccaat cacatgatgt cacccagaca tcaggcatac ccactagtgt
gaaatagaca 11700tcagaattaa gaaaaacgta gggtccaagt ggttccccgt
tatggactcg ctatctgtca 11760accagatctt ataccctgaa gttcacctag
atagcccgat agttaccaat aagatagtag 11820ccatcctgga gtatgctcga
gtccctcacg cttacagcct ggaggaccct acactgtgtc 11880agaacatcaa
gcaccgccta aaaaacggat tttccaacca aatgattata aacaatgtgg
11940aagttgggaa tgtcatcaag tccaagctta ggagttatcc ggcccactct
catattccat 12000atccaaattg taatcaggat ttatttaaca tagaagacaa
agagtcaacg aggaagatcc 12060gtgaactcct caaaaagggg aattcgctgt
actccaaagt cagtgataag gttttccaat 12120gcttaaggga cactaactca
cggcttggcc taggctccga attgagggag gacatcaagg 12180agaaagttat
taacttggga gtttacatgc acagctccca gtggtttgag ccctttctgt
12240tttggtttac agtcaagact gagatgaggt cagtgattaa atcacaaacc
catacttgcc 12300ataggaggag acacacacct gtattcttca ctggtagttc
agttgagttg ctaatctctc 12360gtgaccttgt tgctataatc agtaaagagt
ctcaacatgt atattacctg acatttgaac 12420tggttttgat gtattgtgat
gtcatagagg ggaggttaat gacagagacc gctatgacta 12480ttgatgctag
gtatacagag cttctaggaa gagtcagata catgtggaaa ctgatagatg
12540gtttcttccc tgcactcggg aatccaactt atcaaattgt agccatgctg
gagcctcttt 12600cacttgctta cctgcagctg agggatataa cagtagaact
cagaggtgct ttccttaacc 12660actgctttac tgaaatacat gatgttcttg
accaaaacgg gttttctgat gaaggtactt 12720atcatgagtt aactgaagct
ctagattaca ttttcataac tgatgacata catctgacag 12780gggagatttt
ctcatttttc agaagtttcg gccaccccag acttgaagca gtaacggctg
12840ctgaaaatgt taggaaatac atgaatcagc ctaaagtcat tgtgtatgag
actctgatga 12900aaggtcatgc catattttgt ggaatcataa tcaacggcta
tcgtgacagg cacggaggca 12960gttggccacc gctgaccctc cccctgcatg
ctgcagacac aatccggaat gctcaagctt 13020caggtgaagg gttaacacat
gagcagtgcg ttgataactg gaaatctttt gctggagtga 13080aatttggctg
ctttatgcct cttagcctgg atagtgatct gacaatgtac ctaaaggaca
13140aggcacttgc tgctctccaa agggaatggg attcagttta cccgaaagag
ttcctgcgtt 13200acgaccctcc caagggaacc gggtcacgga ggcttgtaga
tgttttcctt aatgattcga 13260gctttgaccc atatgatgtg ataatgtatg
ttgtaagtgg agcttacctc catgaccctg 13320agttcaacct gtcttacagc
ctgaaagaaa aggagatcaa ggaaacaggt agactttttg 13380ctaaaatgac
ttacaaaatg agggcatgcc aagtgattgc tgaaaatcta atctcaaacg
13440ggattggcaa atattttaag gacaatggga tggccaagga tgagcacgat
ttgactaagg 13500cactccacac tctagctgtc tcaggagtcc ccaaagatct
caaagaaagt cacagggggg 13560ggccagtctt aaaaacctac tcccgaagcc
cagtccacac aagtaccagg aacgtgagag 13620cagcaaaagg gtttataggg
ttccctcaag taattcggca ggaccaagac actgatcatc 13680cggagaatat
ggaagcttac gagacagtca gtgcatttat cacgactgat ctcaagaagt
13740actgccttaa ttggagatat gagaccatca gcttgtttgc acagaggcta
aatgagattt 13800acggattgcc ctcatttttc cagtggctgc ataagaggct
tgagacctct gtcctgtatg 13860taagtgaccc tcattgcccc cccgaccttg
acgcccatat cccgttatat aaagtcccca 13920atgatcaaat cttcattaag
taccctatgg gaggtataga agggtattgt cagaagctgt 13980ggaccatcag
caccattccc tatctatacc tggctgctta tgagagcgga gtaaggattg
14040cttcgttagt gcaaggggac aatcagacca tagccgtaac aaaaagggta
cccagcacat 14100ggccctacaa ccttaagaaa cgggaagctg ctagagtaac
tagagattac tttgtaattc 14160ttaggcaaag gctacatgat attggccatc
acctcaaggc aaatgagaca attgtttcat 14220cacatttttt tgtctattca
aaaggaatat attatgatgg gctacttgtg tcccaatcac 14280tcaagagcat
cgcaagatgt gtattctggt cagagactat agttgatgaa acaagggcag
14340catgcagtaa tattgctaca acaatggcta aaagcatcga gagaggttat
gaccgttacc 14400ttgcatattc cctgaacgtc ctaaaagtga tacagcaaat
tctgatctct cttggcttca 14460caatcaattc aaccatgacc cgggatgtag
tcatacccct cctcacaaac aacgacctct 14520taataaggat ggcactgttg
cccgctccta ttggggggat gaattatctg aatatgagca 14580ggctgtttgt
cagaaacatc ggtgatccag taacatcatc aattgctgat ctcaagagaa
14640tgattctcgc ctcactaatg cctgaagaga ccctccatca agtaatgaca
caacaaccgg 14700gggactcttc attcctagac tgggctagcg acccttactc
agcaaatctt gtatgtgtcc 14760agagcatcac tagactcctc aagaacataa
ctgcaaggtt tgtcctgatc catagtccaa 14820acccaatgtt aaaaggatta
ttccatgatg acagtaaaga agaggacgag ggactggcgg 14880cattcctcat
ggacaggcat attatagtac ctagggcagc tcatgaaatc ctggatcata
14940gtgtcacagg ggcaagagag tctattgcag gcatgctgga taccacaaaa
ggcttgattc 15000gagccagcat gaggaagggg gggttaacct ctcgagtgat
aaccagattg tccaattatg 15060actatgaaca attcagagca gggatggtgc
tattgacagg aagaaagaga aatgtcctca 15120ttgacaaaga gtcatgttca
gtgcagctgg cgagagctct aagaagccat atgtgggcga 15180ggctagctcg
aggacggcct atttacggcc ttgaggtccc tgatgtacta gaatctatgc
15240gaggccacct tattcggcgt catgagacat gtgtcatctg cgagtgtgga
tcagtcaact 15300acggatggtt ttttgtcccc tcgggttgcc aactggatga
tattgacaag gaaacatcat 15360ccttgagagt cccatatatt ggttctacca
ctgatgagag aacagacatg aagcttgcct 15420tcgtaagagc cccaagtcga
tccttgcgat ctgctgttag aatagcaaca gtgtactcat 15480gggcttacgg
tgatgatgat agctcttgga acgaagcctg gttgttggct aggcaaaggg
15540ccaatgtgag cctggaggag ctaagggtga tcactcccat ctcaacttcg
actaatttag 15600cgcataggtt gagggatcgt agcactcaag tgaaatactc
aggtacatcc cttgtccgag 15660tggcgaggta taccacaatc tccaacgaca
atctctcatt tgtcatatca gataagaagg 15720ttgatactaa ctttatatac
caacaaggaa tgcttctagg gttgggtgtt ttagaaacat 15780tgtttcgact
cgagaaagat accggatcat ctaacacggt attacatctt cacgtcgaaa
15840cagattgttg cgtgatcccg atgatagatc atcccaggat acccagctcc
cgcaagctag 15900agctgagggc agagctatgt accaacccat tgatatatga
taatgcacct ttaattgaca 15960gagatgcaac aaggctatac acccagagcc
ataggaggca ccttgtggaa tttgttacat 16020ggtccacacc ccaactatat
cacattttag ctaagtccac agcactatct atgattgacc 16080tggtaacaaa
atttgagaag gaccatatga atgaaatttc agctctcata ggggatgacg
16140atatcaatag tttcataact gagtttctgc tcatagagcc aagattattc
actatctact 16200tgggccagtg tgcggccatc aattgggcat ttgatgtaca
ttatcataga ccatcaggga 16260aatatcagat gggtgagctg ttgtcatcgt
tcctttctag aatgagcaaa ggagtgttta 16320aggtgcttgt caatgctcta
agccacccaa agatctacaa gaaattctgg cattgtggta 16380ttatagagcc
tatccatggt ccttcacttg atgctcaaaa cttgcacaca actgtgtgca
16440acatggttta cacatgctat atgacctacc tcgacctgtt gttgaatgaa
gagttagaag 16500agttcacatt tctcttgtgt gaaagcgacg aggatgtagt
accggacaga ttcgacaaca 16560tccaggcaaa acacttatgt gttctggcag
atttgtactg tcaaccaggg acctgcccac 16620caattcgagg tctaagaccg
gtagagaaat gtgcagttct aaccgaccat atcaaggcag 16680aggctatgtt
atctccagca ggatcttcgt ggaacataaa tccaattatt gtagaccatt
16740actcatgctc tctgacttat ctccggcgag gatcgatcaa acagataaga
ttgagagttg 16800atccaggatt cattttcgac gccctcgctg aggtaaatgt
cagtcagcca aagatcggca 16860gcaacaacat ctcaaatatg agcatcaagg
ctttcagacc cccacacgat gatgttgcaa 16920aattgctcaa agatatcaac
acaagcaagc acaatcttcc catttcaggg ggcaatctcg 16980ccaattatga
aatccatgct ttccgcagaa tcgggttgaa ctcatctgct tgctacaaag
17040ctgttgagat atcaacatta attaggagat gccttgagcc aggggaggac
ggcttgttct 17100tgggtgaggg atcgggttct atgttgatca cttataaaga
gatacttaaa ctaaacaagt 17160gcttctataa tagtggggtt tccgccaatt
ctagatctgg tcaaagggaa ttagcaccct 17220atccctccga agttggcctt
gtcgaacaca gaatgggagt aggtaatatt gtcaaagtgc 17280tctttaacgg
gaggcccgaa gtcacgtggg taggcagtgt agattgcttc aatttcatag
17340ttagtaatat ccctacctct agtgtggggt ttatccattc agatatagag
accttgcctg 17400acaaagatac tatagagaag ctagaggaat tggcagccat
cttatcgatg gctctgctcc 17460tgggcaaaat aggatcaata ctggtgatta
agcttatgcc tttcagcggg gattttgttc 17520agggatttat aagttatgta
gggtctcatt atagagaagt gaaccttgta taccctagat 17580acagcaactt
catctctact gaatcttatt tggttatgac agatctcaag gctaaccggc
17640taatgaatcc tgaaaagatt aagcagcaga taattgaatc atctgtgagg
acttcacctg 17700gacttatagg tcacatccta tccattaagc aactaagctg
catacaagca attgtgggag 17760acgcagttag tagaggtgat atcaatccta
ctctgaaaaa acttacacct atagagcagg 17820tgctgatcaa ttgcgggttg
gcaattaacg gacctaagct gtgcaaagaa ttgatccacc 17880atgatgttgc
ctcagggcaa gatggattgc ttaattctat actcatcctc tacagggagt
17940tggcaagatt caaagacaac caaagaagtc aacaagggat gttccacgct
taccccgtat 18000tggtaagtag caggcaacga gaacttatat ctaggatcac
ccgcaaattc tgggggcaca 18060ttcttcttta ctccgggaac aaaaagttga
taaataagtt tatccagaat ctcaagtccg 18120gctatctgat actagactta
caccagaata tcttcgttaa gaatctatcc aagtcagaga 18180aacagattat
tatgacgggg ggtttgaaac gtgagtgggt ttttaaggta acagtcaagg
18240agaccaaaga atggtataag ttagtcggat acagtgccct gattaaggac
taattggttg 18300aactccggaa ccctaatcct gccctaggtg gttaggcatt
atttgcaata tattaaagaa 18360aactttgaaa atacgaagtt tctattccca
gctttgtctg 18400718420DNAArtificialartificial MV genome
MeVac_P_FmIL-12_Hbl_anti_CD20 7accaaacaaa gttgggtaag gatagttcaa
tcaatgatca tcttctagtg cacttaggat 60tcaagatcct attatcaggg acaagagcag
gattagggat atccgagatg gccacacttt 120taaggagctt agcattgttc
aaaagaaaca aggacaaacc acccattaca tcaggatccg 180gtggagccat
cagaggaatc aaacacatta ttatagtacc aatccctgga gattcctcaa
240ttaccactcg atccagactt ctggaccggt tggtgaggtt aattggaaac
ccggatgtga 300gcgggcccaa actaacaggg gcactaatag gtatattatc
cttatttgtg gagtctccag 360gtcaattgat tcagaggatc accgatgacc
ctgacgttag cataaggctg ttagaggttg 420tccagagtga ccagtcacaa
tctggcctta ccttcgcatc aagaggtacc aacatggagg 480atgaggcgga
ccaatacttt tcacatgatg atccaattag tagtgatcaa tccaggttcg
540gatggttcgg gaacaaggaa atctcagata ttgaagtgca agaccctgag
ggattcaaca 600tgattctggg taccatccta gcccaaattt gggtcttgct
cgcaaaggcg gttacggccc 660cagacacggc agctgattcg gagctaagaa
ggtggataaa gtacacccaa caaagaaggg 720tagttggtga atttagattg
gagagaaaat ggttggatgt ggtgaggaac aggattgccg 780aggacctctc
cttacgccga ttcatggtcg ctctaatcct ggatatcaag agaacacccg
840gaaacaaacc caggattgct gaaatgatat gtgacattga tacatatatc
gtagaggcag 900gattagccag ttttatcctg actattaagt ttgggataga
aactatgtat cctgctcttg 960gactgcatga atttgctggt gagttatcca
cacttgagtc cttgatgaac ctttaccagc 1020aaatggggga aactgcaccc
tacatggtaa tcctggagaa ctcaattcag aacaagttca 1080gtgcaggatc
ataccctctg ctctggagct atgccatggg agtaggagtg gaacttgaaa
1140actccatggg aggtttgaac tttggccgat cttactttga tccagcatat
tttagattag 1200ggcaagagat ggtaaggagg tcagctggaa aggtcagttc
cacattggca tctgaactcg 1260gtatcactgc cgaggatgca aggcttgttt
cagagattgc aatgcatact actgaggaca 1320agatcagtag agcggttgga
cccagacaag cccaagtatc atttctacac ggtgatcaaa 1380gtgagaatga
gctaccgaga ttggggggca aggaagatag gagggtcaaa cagagtcgag
1440gagaagccag ggagagctac
agagaaaccg ggcccagcag agcaagtgat gcgagagctg 1500cccatcttcc
aaccggcaca cccctagaca ttgacactgc aacggagtcc agccaagatc
1560cgcaggacag tcgaaggtca gctgacgccc tgcttaggct gcaagccatg
gcaggaatct 1620cggaagaaca aggctcagac acggacaccc ctatagtgta
caatgacaga aatcttctag 1680actaggtgcg agaggccgag ggccagaaca
acatccgcct accatccatc attgttataa 1740aaaacttagg aaccaggtcc
acacagccgc cagcccatca accatccact cccacgattg 1800gagccaatgg
cagaagagca ggcacgccat gtcaaaaacg gactggaatg catccgggct
1860ctcaaggccg agcccatcgg ctcactggcc atcgaggaag ctatggcagc
atggtcagaa 1920atatcagaca acccaggaca ggagcgagcc acctgcaggg
aagagaaggc aggcagttcg 1980ggtctcagca aaccatgcct ctcagcaatt
ggatcaactg aaggcggtgc acctcgcatc 2040cgcggtcagg gacctggaga
gagcgatgac gacgctgaaa ctttgggaat ccccccaaga 2100aatctccagg
catcaagcac tgggttacag tgttattacg tttatgatca cagcggtgaa
2160gcggttaagg gaatccaaga tgctgactct atcatggttc aatcaggcct
tgatggtgat 2220agcaccctct caggaggaga caatgaatct gaaaacagcg
atgtggatat tggcgaacct 2280gataccgagg gatatgctat cactgaccgg
ggatctgctc ccatctctat ggggttcagg 2340gcttctgatg ttgaaactgc
agaaggaggg gagatccacg agctcctgag actccaatcc 2400agaggcaaca
actttccgaa gcttgggaaa actctcaatg ttcctccgcc cccggacccc
2460ggtagggcca gcacttccgg gacacccatt aaaaagggca cagacgcgag
attagcctca 2520tttggaacgg agatcgcgtc tttattgaca ggtggtgcaa
cccaatgtgc tcgaaagtca 2580ccctcggaac catcagggcc aggtgcacct
gcggggaatg tccccgagtg tgtgagcaat 2640gccgcactga tacaggagtg
gacacccgaa tctggtacca caatctcccc gagatcccag 2700aataatgaag
aagggggaga ctattatgat gatgagctgt tctctgatgt ccaagatatt
2760aaaacagcct tggccaaaat acacgaggat aatcagaaga taatctccaa
gctagaatca 2820ctgctgttat tgaagggaga agttgagtca attaagaagc
agatcaacag gcaaaatatc 2880agcatatcca ccctggaagg acacctctca
agcatcatga tcgccattcc tggacttggg 2940aaggatccca acgaccccac
tgcagatgtc gaaatcaatc ccgacttgaa acccatcata 3000ggcagagatt
caggccgagc actggccgaa gttctcaaga aacccgttgc cagccgacaa
3060ctccaaggaa tgacaaatgg acggaccagt tccagaggac agctgctgaa
ggaatttcag 3120ctaaagccga tcgggaaaaa gatgagctca gccgtcgggt
ttgttcctga caccggccct 3180gcatcacgca gtgtaatccg ctccattata
aaatccagcc ggctagagga ggatcggaag 3240cgttacctga tgactctcct
tgatgatatc aaaggagcca atgatcttgc caagttccac 3300cagatgctga
tgaagataat aatgaagtag ctacagctca acttacctgc caaccccatg
3360ccagtcgacc caactagcaa cctaaatcca ttataaaaaa cttaggaacc
aggtccacac 3420agctcgagtc gcgcgtggcc accatgtgtc ctcagaagct
aaccatctcc tggtttgcca 3480tcgttttgct ggtgtcccca ctcatggcca
tgtgggagct ggagaaagac gtttatgttg 3540tagaggtgga ctggactccc
gatgcccctg gagaaacagt gaacctcacc tgtgacacgc 3600ctgaagaaga
tgacatcacc tggacctcag accagagaca tggagtcata ggctctggaa
3660agaccctgac catcactgtc aaagagtttc tagatgctgg ccagtacacc
tgccacaaag 3720gaggcgagac tctgagccac tcacatctgc tgctccacaa
gaaggaaaat ggaatttggt 3780ccactgaaat tttaaaaaat ttcaaaaaca
agactttcct gaagtgtgaa gcaccaaatt 3840actccggacg gttcacgtgc
tcatggctgg tgcaaagaaa catggacttg aagttcaaca 3900tcaagagcag
tagcagttcc cctgactctc gggcagtgac atgtggaatg gcgtctctgt
3960ctgcagagaa ggtcacactg gaccaaaggg actatgagaa gtattcagtg
tcctgccagg 4020aggatgtcac ctgcccaact gccgaggaga ccctgcccat
tgaactggcg ttggaagcac 4080ggcagcagaa taaatatgag aactacagca
ccagcttctt catcagggac atcatcaaac 4140cagacccgcc caagaacttg
cagatgaagc ctttgaagaa ctcacaggtg gaggtcagct 4200gggagtaccc
tgactcctgg agcactcccc attcctactt ctccctcaag ttctttgttc
4260gaatccagcg caagaaagaa aagatgaagg agacagagga ggggtgtaac
cagaaaggtg 4320cgttcctcgt agagaagaca tctaccgaag tccaatgcaa
aggcgggaat gtctgcgtgc 4380aagctcagga tcgctattac aattcctcgt
gcagcaagtg ggcatgtgtt ccctgcaggg 4440tccgatccgg tggcggtggc
tcgggcggtg gtgggtcggg tggcggcgga tctagggtca 4500ttccagtctc
tggacctgcc aggtgtctta gccagtcccg aaacctgctg aagaccacag
4560atgacatggt gaagacggcc agagaaaaac tgaaacatta ttcctgcact
gctgaagaca 4620tcgatcatga agacatcaca cgggaccaaa ccagcacatt
gaagacctgt ttaccactgg 4680aactacacaa gaacgagagt tgcctggcta
ctagagagac ttcttccaca acaagaggga 4740gctgcctgcc cccacagaag
acgtctttga tgatgaccct gtgccttggt agcatctatg 4800aggacttgaa
gatgtaccag acagagttcc aggccatcaa cgcagcactt cagaatcaca
4860accatcagca gatcattcta gacaagggca tgctggtggc catcgatgag
ctgatgcagt 4920ctctgaatca taatggcgag actctgcgcc agaaacctcc
tgtgggagaa gcagaccctt 4980acagagtgaa aatgaagctc tgcatcctgc
ttcacgcctt cagcacccgc gtcgtgacca 5040tcaacagggt gatgggctat
ctgagctccg cctgataatc gcgcgcgtgc tagtacaacc 5100taaatccatt
ataaaaaact taggagcaaa gtgattgcct cccaaggtcc acaatgacag
5160agacctacga cttcgacaag tcggcatggg acatcaaagg gtcgatcgct
ccgatacaac 5220ccaccaccta cagtgatggc aggctggtgc cccaggtcag
agtcatagat cctggtctag 5280gcgacaggaa ggatgaatgc tttatgtaca
tgtttctgct gggggttgtt gaggacagcg 5340attccctagg gcctccaatc
gggcgagcat ttgggttcct gcccttaggt gttggcagat 5400ccacagcaaa
gcccgaaaaa ctcctcaaag aggccactga gcttgacata gttgttagac
5460gtacagcagg gctcaatgaa aaactggtgt tctacaacaa caccccacta
actctcctca 5520caccttggag aaaggtccta acaacaggga gtgtcttcaa
cgcaaaccaa gtgtgcaatg 5580cggttaatct gataccgctc gataccccgc
agaggttccg tgttgtttat atgagcatca 5640cccgtctttc ggataacggg
tattacaccg ttcctagaag aatgctggaa ttcagatcgg 5700tcaatgcagt
ggccttcaac ctgctggtga cccttaggat tgacaaggcg ataggccctg
5760ggaagatcat cgacaataca gagcaacttc ctgaggcaac atttatggtc
cacatcggga 5820acttcaggag aaagaagagt gaagtctact ctgccgatta
ttgcaaaatg aaaatcgaaa 5880agatgggcct ggtttttgca cttggtggga
tagggggcac cagtcttcac attagaagca 5940caggcaaaat gagcaagact
ctccatgcac aactcgggtt caagaagacc ttatgttacc 6000cgctgatgga
tatcaatgaa gaccttaatc gattactctg gaggagcaga tgcaagatag
6060taagaatcca ggcagttttg cagccatcag ttcctcaaga attccgcatt
tacgacgacg 6120tgatcataaa tgatgaccaa ggactattca aagttctgta
gaccgtagtg cccagcaatg 6180cccgaaaacg acccccctca caatgacagc
cagaaggccc ggacaaaaaa gccccctccg 6240aaagactcca cggaccaagc
gagaggccag ccagcagccg acggcaagcg cgaacaccag 6300gcggccccag
cacagaacag ccctgacaca aggccaccac cagccacccc aatctgcatc
6360ctcctcgtgg gacccccgag gaccaacccc caaggctgcc cccgatccaa
accaccaacc 6420gcatccccac cacccccggg aaagaaaccc ccagcaattg
gaaggcccct ccccctcttc 6480ctcaacacaa gaactccaca accgaaccgc
acaagcgacc gaggtgaccc aaccgcaggc 6540atccgactcc ctagacagat
cctctctccc cggcaaacta aacaaaactt agggccaagg 6600aacatacaca
cccaacagaa cccagacccc ggcccacggc gccgcgcccc caacccccga
6660caaccagagg gagcccccaa ccaatcccgc cggctccccc ggtgcccaca
ggcagggaca 6720ccaacccccg aacagaccca gcacccaacc atcgacaatc
caagacgggg gggccccccc 6780aaaaaaaggc ccccaggggc cgacagccag
caccgcgagg aagcccaccc accccacaca 6840cgaccacggc aaccaaacca
gaacccagac caccctgggc caccagctcc cagactcggc 6900catcaccccg
cagaaaggaa aggccacaac ccgcgcaccc cagccccgat ccggcgggga
6960gccacccaac ccgaaccagc acccaagagc gatccccgaa ggacccccga
accgcaaagg 7020acatcagtat cccacagcct ctccaagtcc cccggtctcc
tcctcttctc gaagggacca 7080aaagatcaat ccaccacacc cgacgacact
caactcccca cccctaaagg agacaccggg 7140aatcccagaa tcaagactca
tccaatgtcc atcatgggtc tcaaggtgaa cgtctctgcc 7200atattcatgg
cagtactgtt aactctccaa acacccaccg gtcaaatcca ttggggcaat
7260ctctctaaga taggggtggt aggaatagga agtgcaagct acaaagttat
gactcgttcc 7320agccatcaat cattagtcat aaaattaatg cccaatataa
ctctcctcaa taactgcacg 7380agggtagaga ttgcagaata caggagacta
ctgagaacag ttttggaacc aattagagat 7440gcacttaatg caatgaccca
gaatataaga ccggttcaga gtgtagcttc aagtaggaga 7500cacaagagat
ttgcgggagt agtcctggca ggtgcggccc taggcgttgc cacagctgct
7560cagataacag ccggcattgc acttcaccag tccatgctga actctcaagc
catcgacaat 7620ctgagagcga gcctggaaac tactaatcag gcaattgaga
caatcagaca agcagggcag 7680gagatgatat tggctgttca gggtgtccaa
gactacatca ataatgagct gataccgtct 7740atgaaccaac tatcttgtga
tttaatcggc cagaagctcg ggctcaaatt gctcagatac 7800tatacagaaa
tcctgtcatt atttggcccc agtttacggg accccatatc tgcggagata
7860tctatccagg ctttgagcta tgcgcttgga ggagacatca ataaggtgtt
agaaaagctc 7920ggatacagtg gaggtgattt actgggcatc ttagagagcg
gaggaataaa ggcccggata 7980actcacgtcg acacagagtc ctacttcatt
gtcctcagta tagcctatcc gacgctgtcc 8040gagattaagg gggtgattgt
ccaccggcta gagggggtct cgtacaacat aggctctcaa 8100gagtggtata
ccactgtgcc caagtatgtt gcaacccaag ggtaccttat ctcgaatttt
8160gatgagtcat cgtgtacttt catgccagag gggactgtgt gcagccaaaa
tgccttgtac 8220ccgatgagtc ctctgctcca agaatgcctc cgggggtaca
ccaagtcctg tgctcgtaca 8280ctcgtatccg ggtcttttgg gaaccggttc
attttatcac aagggaacct aatagccaat 8340tgtgcatcaa tcctttgcaa
gtgttacaca acaggaacga tcattaatca agaccctgac 8400aagatcctaa
catacattgc tgccgatcac tgcccggtag tcgaggtgaa cggcgtgacc
8460atccaagtcg ggagcaggag gtatccagac gctgtgtact tgcacagaat
tgacctcggt 8520cctcccatat cattggagag gttggacgta gggacaaatc
tggggaatgc aattgctaag 8580ttggaggatg ccaaggaatt gttggagtca
tcggaccaga tattgaggag tatgaaaggt 8640ttatcgagca ctagcatagt
ctacatcctg attgcagtgt gtcttggagg gttgataggg 8700atccccgctt
taatatgttg ctgcaggggg cgttgtaaca aaaagggaga acaagttggt
8760atgtcaagac caggcctaaa gcctgatctt acgggaacat caaaatccta
tgtaaggtcg 8820ctctgatcct ctacaactct tgaaacacaa atgtcccaca
agtctcctct tcgtcatcaa 8880gcaaccaccg cacccagcat caagcccacc
tgaaattatc tccggcttcc ctctggccga 8940acaatatcgg tagttaatca
aaacttaggg tgcaagatca tccacaatgt caccacaacg 9000agaccggata
aatgccttct acaaagataa cccccatccc aagggaagta ggatagtcat
9060taacagagaa catcttatga ttgatagacc ttatgttttg ctggctgttc
tgtttgtcat 9120gtttctgagc ttgatcgggt tgctagccat tgcaggcatt
agacttcatc gggcagccat 9180ctacaccgca gagatccata aaagcctcag
caccaatcta gatgtaacta actcaatcga 9240gcatcaggtc aaggacgtgc
tgacaccact cttcaaaatc atcggtgatg aagtgggcct 9300gaggacacct
cagagattca ctgacctagt gaaattaatc tctgacaaga ttaaattcct
9360taatccggat agggagtacg acttcagaga tctcacttgg tgtatcaacc
cgccagagag 9420aatcaaattg gattatgatc aatactgtgc agatgtggct
gctgaagagc tcatgaatgc 9480attggtgaac tcaactctac tggagaccag
aacaaccaat cagttcctag ctgtctcaaa 9540gggaaactgc tcagggccca
ctacaatcag aggtcaattc tcaaacatgt cgctgtccct 9600gttagacttg
tatttaggtc gaggttacaa tgtgtcatct atagtcacta tgacatccca
9660gggaatgtat gggggaactt acctagtgga aaagcctaat ctgagcagca
aaaggtcaga 9720gttgtcacaa ctgagcatgt accgagtgtt tgaagtaggt
gttatcagaa atccgggttt 9780gggggctccg gtgttccata tgacaaacta
tcttgagcaa ccagtcagta atgatctcag 9840caactgtatg gtggctttgg
gggagctcaa actcgcagcc ctttgtcacg gggaagattc 9900tatcacaatt
ccctatcagg gatcagggaa aggtgtcagc ttccagctcg tcaagctagg
9960tgtctggaaa tccccaaccg acatgcaatc ctgggtcccc ttatcaacgg
atgatccagt 10020gatagacagg ctttacctct catctcacag aggtgttatc
gctgacaatc aagcaaaatg 10080ggctgtcccg acaacacgaa cagatgacaa
gttgcgaatg gagacatgct tccaacaggc 10140gtgtaagggt aaaatccaag
cactctgcga gaatcccgag tgggcaccat tgaaggataa 10200caggattcct
tcatacgggg tcttgtctgt tgatctgagt ctgacagttg agcttaaaat
10260caaaattgct tcgggattcg ggccattgat cacacacggt tcagggatgg
acctatacaa 10320atccaaccac aacaatgtgt attggctgac tatcccgcca
atgaagaacc tagccttagg 10380tgtaatcaac acattggagt ggataccgag
attcaaggtt agtcccgcac tcttcactgt 10440cccaattaag gaagcaggcg
aagactgcca tgccccaaca tacctacctg cggaggtgga 10500tggtgatgtc
aaactcagtt ccaatctggt gattctacct ggtcaagatc tccaatatgt
10560tttggcaacc tacgatactt ccgcggttga acatgctgtg gtttattacg
tttacagccc 10620aagccgccta tcgtcttact tttatccttt taggttgcct
ataaaggggg tccccatcga 10680attacaagtg gaatgcttca catgggacca
aaaactctgg tgccgtcact tctgtgtgct 10740tgcggactca gaatctggtg
gacatatcac tcactctggg atggtgggca tgggagtcag 10800ctgcacagtc
acccgggaag atggaaccaa tgcggcccag ccggccatcg agggaaggat
10860ggctcaggtt cagctggtcc agtcaggggc tgagctggtg aagcctgggg
cctcagtgaa 10920gatgtcctgc aaggcttctg gctacacatt taccagttac
aatatgcact gggtaaagca 10980gacacctgga cagggcctgg aatggattgg
agctatttat ccaggaaatg gtgatacttc 11040ctacaatcag aagttcaaag
gcaaggccac attgactgca gacaaatcct ccagcacagc 11100ctacatgcag
ctcagcagcc tgacatctga ggactctgcg gtctattact gtgcaagagc
11160gcaattacga cctaactact ggtacttcga tgtctggggc gcagggacca
cggtcaccgt 11220gagcaagatc tctggtggcg gtggctcggg cggtggtggg
tcgggtggcg gaggctcggg 11280tggctcgagc gacatcgtgc tgtcgcagtc
tccagcaatc ctgtctgcat ctccagggga 11340gaaggtcaca atgacttgca
gggccagctc aagtgtaagt tacatgcact ggtaccagca 11400gaagccagga
tcctccccca aaccctggat ttatgccaca tccaacctgg cttctggagt
11460ccctgctcgc ttcagtggca gtgggtctgg gacctcttac tctctcacaa
tcagcagagt 11520ggaggctgaa gatgctgcca cttattactg ccagcagtgg
attagtaacc cacccacgtt 11580cggtgctggg accaagctgg agctgaaggc
ggccgcaaga ggttctcatc accatcacca 11640tcactaatag ggctgctagt
gaaccaatca catgatgtca cccagacatc aggcataccc 11700actagtgtga
aatagacatc agaattaaga aaaacgtagg gtccaagtgg ttccccgtta
11760tggactcgct atctgtcaac cagatcttat accctgaagt tcacctagat
agcccgatag 11820ttaccaataa gatagtagcc atcctggagt atgctcgagt
ccctcacgct tacagcctgg 11880aggaccctac actgtgtcag aacatcaagc
accgcctaaa aaacggattt tccaaccaaa 11940tgattataaa caatgtggaa
gttgggaatg tcatcaagtc caagcttagg agttatccgg 12000cccactctca
tattccatat ccaaattgta atcaggattt atttaacata gaagacaaag
12060agtcaacgag gaagatccgt gaactcctca aaaaggggaa ttcgctgtac
tccaaagtca 12120gtgataaggt tttccaatgc ttaagggaca ctaactcacg
gcttggccta ggctccgaat 12180tgagggagga catcaaggag aaagttatta
acttgggagt ttacatgcac agctcccagt 12240ggtttgagcc ctttctgttt
tggtttacag tcaagactga gatgaggtca gtgattaaat 12300cacaaaccca
tacttgccat aggaggagac acacacctgt attcttcact ggtagttcag
12360ttgagttgct aatctctcgt gaccttgttg ctataatcag taaagagtct
caacatgtat 12420attacctgac atttgaactg gttttgatgt attgtgatgt
catagagggg aggttaatga 12480cagagaccgc tatgactatt gatgctaggt
atacagagct tctaggaaga gtcagataca 12540tgtggaaact gatagatggt
ttcttccctg cactcgggaa tccaacttat caaattgtag 12600ccatgctgga
gcctctttca cttgcttacc tgcagctgag ggatataaca gtagaactca
12660gaggtgcttt ccttaaccac tgctttactg aaatacatga tgttcttgac
caaaacgggt 12720tttctgatga aggtacttat catgagttaa ctgaagctct
agattacatt ttcataactg 12780atgacataca tctgacaggg gagattttct
catttttcag aagtttcggc caccccagac 12840ttgaagcagt aacggctgct
gaaaatgtta ggaaatacat gaatcagcct aaagtcattg 12900tgtatgagac
tctgatgaaa ggtcatgcca tattttgtgg aatcataatc aacggctatc
12960gtgacaggca cggaggcagt tggccaccgc tgaccctccc cctgcatgct
gcagacacaa 13020tccggaatgc tcaagcttca ggtgaagggt taacacatga
gcagtgcgtt gataactgga 13080aatcttttgc tggagtgaaa tttggctgct
ttatgcctct tagcctggat agtgatctga 13140caatgtacct aaaggacaag
gcacttgctg ctctccaaag ggaatgggat tcagtttacc 13200cgaaagagtt
cctgcgttac gaccctccca agggaaccgg gtcacggagg cttgtagatg
13260ttttccttaa tgattcgagc tttgacccat atgatgtgat aatgtatgtt
gtaagtggag 13320cttacctcca tgaccctgag ttcaacctgt cttacagcct
gaaagaaaag gagatcaagg 13380aaacaggtag actttttgct aaaatgactt
acaaaatgag ggcatgccaa gtgattgctg 13440aaaatctaat ctcaaacggg
attggcaaat attttaagga caatgggatg gccaaggatg 13500agcacgattt
gactaaggca ctccacactc tagctgtctc aggagtcccc aaagatctca
13560aagaaagtca cagggggggg ccagtcttaa aaacctactc ccgaagccca
gtccacacaa 13620gtaccaggaa cgtgagagca gcaaaagggt ttatagggtt
ccctcaagta attcggcagg 13680accaagacac tgatcatccg gagaatatgg
aagcttacga gacagtcagt gcatttatca 13740cgactgatct caagaagtac
tgccttaatt ggagatatga gaccatcagc ttgtttgcac 13800agaggctaaa
tgagatttac ggattgccct catttttcca gtggctgcat aagaggcttg
13860agacctctgt cctgtatgta agtgaccctc attgcccccc cgaccttgac
gcccatatcc 13920cgttatataa agtccccaat gatcaaatct tcattaagta
ccctatggga ggtatagaag 13980ggtattgtca gaagctgtgg accatcagca
ccattcccta tctatacctg gctgcttatg 14040agagcggagt aaggattgct
tcgttagtgc aaggggacaa tcagaccata gccgtaacaa 14100aaagggtacc
cagcacatgg ccctacaacc ttaagaaacg ggaagctgct agagtaacta
14160gagattactt tgtaattctt aggcaaaggc tacatgatat tggccatcac
ctcaaggcaa 14220atgagacaat tgtttcatca catttttttg tctattcaaa
aggaatatat tatgatgggc 14280tacttgtgtc ccaatcactc aagagcatcg
caagatgtgt attctggtca gagactatag 14340ttgatgaaac aagggcagca
tgcagtaata ttgctacaac aatggctaaa agcatcgaga 14400gaggttatga
ccgttacctt gcatattccc tgaacgtcct aaaagtgata cagcaaattc
14460tgatctctct tggcttcaca atcaattcaa ccatgacccg ggatgtagtc
atacccctcc 14520tcacaaacaa cgacctctta ataaggatgg cactgttgcc
cgctcctatt ggggggatga 14580attatctgaa tatgagcagg ctgtttgtca
gaaacatcgg tgatccagta acatcatcaa 14640ttgctgatct caagagaatg
attctcgcct cactaatgcc tgaagagacc ctccatcaag 14700taatgacaca
acaaccgggg gactcttcat tcctagactg ggctagcgac ccttactcag
14760caaatcttgt atgtgtccag agcatcacta gactcctcaa gaacataact
gcaaggtttg 14820tcctgatcca tagtccaaac ccaatgttaa aaggattatt
ccatgatgac agtaaagaag 14880aggacgaggg actggcggca ttcctcatgg
acaggcatat tatagtacct agggcagctc 14940atgaaatcct ggatcatagt
gtcacagggg caagagagtc tattgcaggc atgctggata 15000ccacaaaagg
cttgattcga gccagcatga ggaagggggg gttaacctct cgagtgataa
15060ccagattgtc caattatgac tatgaacaat tcagagcagg gatggtgcta
ttgacaggaa 15120gaaagagaaa tgtcctcatt gacaaagagt catgttcagt
gcagctggcg agagctctaa 15180gaagccatat gtgggcgagg ctagctcgag
gacggcctat ttacggcctt gaggtccctg 15240atgtactaga atctatgcga
ggccacctta ttcggcgtca tgagacatgt gtcatctgcg 15300agtgtggatc
agtcaactac ggatggtttt ttgtcccctc gggttgccaa ctggatgata
15360ttgacaagga aacatcatcc ttgagagtcc catatattgg ttctaccact
gatgagagaa 15420cagacatgaa gcttgccttc gtaagagccc caagtcgatc
cttgcgatct gctgttagaa 15480tagcaacagt gtactcatgg gcttacggtg
atgatgatag ctcttggaac gaagcctggt 15540tgttggctag gcaaagggcc
aatgtgagcc tggaggagct aagggtgatc actcccatct 15600caacttcgac
taatttagcg cataggttga gggatcgtag cactcaagtg aaatactcag
15660gtacatccct tgtccgagtg gcgaggtata ccacaatctc caacgacaat
ctctcatttg 15720tcatatcaga taagaaggtt gatactaact ttatatacca
acaaggaatg cttctagggt 15780tgggtgtttt agaaacattg tttcgactcg
agaaagatac cggatcatct aacacggtat 15840tacatcttca cgtcgaaaca
gattgttgcg tgatcccgat gatagatcat cccaggatac 15900ccagctcccg
caagctagag ctgagggcag agctatgtac caacccattg atatatgata
15960atgcaccttt aattgacaga gatgcaacaa ggctatacac ccagagccat
aggaggcacc 16020ttgtggaatt tgttacatgg tccacacccc aactatatca
cattttagct aagtccacag 16080cactatctat gattgacctg gtaacaaaat
ttgagaagga ccatatgaat gaaatttcag 16140ctctcatagg ggatgacgat
atcaatagtt tcataactga gtttctgctc atagagccaa 16200gattattcac
tatctacttg ggccagtgtg cggccatcaa ttgggcattt gatgtacatt
16260atcatagacc atcagggaaa tatcagatgg gtgagctgtt gtcatcgttc
ctttctagaa 16320tgagcaaagg agtgtttaag gtgcttgtca atgctctaag
ccacccaaag atctacaaga 16380aattctggca ttgtggtatt atagagccta
tccatggtcc ttcacttgat gctcaaaact 16440tgcacacaac tgtgtgcaac
atggtttaca catgctatat gacctacctc gacctgttgt 16500tgaatgaaga
gttagaagag
ttcacatttc tcttgtgtga aagcgacgag gatgtagtac 16560cggacagatt
cgacaacatc caggcaaaac acttatgtgt tctggcagat ttgtactgtc
16620aaccagggac ctgcccacca attcgaggtc taagaccggt agagaaatgt
gcagttctaa 16680ccgaccatat caaggcagag gctatgttat ctccagcagg
atcttcgtgg aacataaatc 16740caattattgt agaccattac tcatgctctc
tgacttatct ccggcgagga tcgatcaaac 16800agataagatt gagagttgat
ccaggattca ttttcgacgc cctcgctgag gtaaatgtca 16860gtcagccaaa
gatcggcagc aacaacatct caaatatgag catcaaggct ttcagacccc
16920cacacgatga tgttgcaaaa ttgctcaaag atatcaacac aagcaagcac
aatcttccca 16980tttcaggggg caatctcgcc aattatgaaa tccatgcttt
ccgcagaatc gggttgaact 17040catctgcttg ctacaaagct gttgagatat
caacattaat taggagatgc cttgagccag 17100gggaggacgg cttgttcttg
ggtgagggat cgggttctat gttgatcact tataaagaga 17160tacttaaact
aaacaagtgc ttctataata gtggggtttc cgccaattct agatctggtc
17220aaagggaatt agcaccctat ccctccgaag ttggccttgt cgaacacaga
atgggagtag 17280gtaatattgt caaagtgctc tttaacggga ggcccgaagt
cacgtgggta ggcagtgtag 17340attgcttcaa tttcatagtt agtaatatcc
ctacctctag tgtggggttt atccattcag 17400atatagagac cttgcctgac
aaagatacta tagagaagct agaggaattg gcagccatct 17460tatcgatggc
tctgctcctg ggcaaaatag gatcaatact ggtgattaag cttatgcctt
17520tcagcgggga ttttgttcag ggatttataa gttatgtagg gtctcattat
agagaagtga 17580accttgtata ccctagatac agcaacttca tctctactga
atcttatttg gttatgacag 17640atctcaaggc taaccggcta atgaatcctg
aaaagattaa gcagcagata attgaatcat 17700ctgtgaggac ttcacctgga
cttataggtc acatcctatc cattaagcaa ctaagctgca 17760tacaagcaat
tgtgggagac gcagttagta gaggtgatat caatcctact ctgaaaaaac
17820ttacacctat agagcaggtg ctgatcaatt gcgggttggc aattaacgga
cctaagctgt 17880gcaaagaatt gatccaccat gatgttgcct cagggcaaga
tggattgctt aattctatac 17940tcatcctcta cagggagttg gcaagattca
aagacaacca aagaagtcaa caagggatgt 18000tccacgctta ccccgtattg
gtaagtagca ggcaacgaga acttatatct aggatcaccc 18060gcaaattctg
ggggcacatt cttctttact ccgggaacaa aaagttgata aataagttta
18120tccagaatct caagtccggc tatctgatac tagacttaca ccagaatatc
ttcgttaaga 18180atctatccaa gtcagagaaa cagattatta tgacgggggg
tttgaaacgt gagtgggttt 18240ttaaggtaac agtcaaggag accaaagaat
ggtataagtt agtcggatac agtgccctga 18300ttaaggacta attggttgaa
ctccggaacc ctaatcctgc cctaggtggt taggcattat 18360ttgcaatata
ttaaagaaaa ctttgaaaat acgaagtttc tattcccagc tttgtctggt
18420815DNAArtificiallinker sequence 8ggggsggggs ggggs
1597DNAArtificialartificial linker sequence 9ggggggs
710543PRTArtificialFmIL-12 fusion polypeptide 10Met Cys Pro Gln Lys
Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu1 5 10 15Val Ser Pro Leu
Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 20 25 30Val Glu Val
Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 35 40 45Thr Cys
Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 50 55 60Arg
His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys65 70 75
80Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr
85 90 95Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile
Trp 100 105 110Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe
Leu Lys Cys 115 120 125Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys
Ser Trp Leu Val Gln 130 135 140Arg Asn Met Asp Leu Lys Phe Asn Ile
Lys Ser Ser Ser Ser Ser Pro145 150 155 160Asp Ser Arg Ala Val Thr
Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 165 170 175Val Thr Leu Asp
Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 180 185 190Glu Asp
Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 195 200
205Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser
210 215 220Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn
Leu Gln225 230 235 240Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val
Ser Trp Glu Tyr Pro 245 250 255Asp Ser Trp Ser Thr Pro His Ser Tyr
Phe Ser Leu Lys Phe Phe Val 260 265 270Arg Ile Gln Arg Lys Lys Glu
Lys Met Lys Glu Thr Glu Glu Gly Cys 275 280 285Asn Gln Lys Gly Ala
Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 290 295 300Cys Lys Gly
Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn305 310 315
320Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly
325 330 335Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Arg Val 340 345 350Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln
Ser Arg Asn Leu 355 360 365Leu Lys Thr Thr Asp Asp Met Val Lys Thr
Ala Arg Glu Lys Leu Lys 370 375 380His Tyr Ser Cys Thr Ala Glu Asp
Ile Asp His Glu Asp Ile Thr Arg385 390 395 400Asp Gln Thr Ser Thr
Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys 405 410 415Asn Glu Ser
Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly 420 425 430Ser
Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu 435 440
445Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala
450 455 460Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile
Leu Asp465 470 475 480Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met
Gln Ser Leu Asn His 485 490 495Asn Gly Glu Thr Leu Arg Gln Lys Pro
Pro Val Gly Glu Ala Asp Pro 500 505 510Tyr Arg Val Lys Met Lys Leu
Cys Ile Leu Leu His Ala Phe Ser Thr 515 520 525Arg Val Val Thr Ile
Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 530 535
540111632DNAArtificialFmIL-12 fusion polypeptide coding sequence
11atgtgtcctc agaagctaac catctcctgg tttgccatcg ttttgctggt gtccccactc
60atggccatgt gggagctgga gaaagacgtt tatgttgtag aggtggactg gactcccgat
120gcccctggag aaacagtgaa cctcacctgt gacacgcctg aagaagatga
catcacctgg 180acctcagacc agagacatgg agtcataggc tctggaaaga
ccctgaccat cactgtcaaa 240gagtttctag atgctggcca gtacacctgc
cacaaaggag gcgagactct gagccactca 300catctgctgc tccacaagaa
ggaaaatgga atttggtcca ctgaaatttt aaaaaatttc 360aaaaacaaga
ctttcctgaa gtgtgaagca ccaaattact ccggacggtt cacgtgctca
420tggctggtgc aaagaaacat ggacttgaag ttcaacatca agagcagtag
cagttcccct 480gactctcggg cagtgacatg tggaatggcg tctctgtctg
cagagaaggt cacactggac 540caaagggact atgagaagta ttcagtgtcc
tgccaggagg atgtcacctg cccaactgcc 600gaggagaccc tgcccattga
actggcgttg gaagcacggc agcagaataa atatgagaac 660tacagcacca
gcttcttcat cagggacatc atcaaaccag acccgcccaa gaacttgcag
720atgaagcctt tgaagaactc acaggtggag gtcagctggg agtaccctga
ctcctggagc 780actccccatt cctacttctc cctcaagttc tttgttcgaa
tccagcgcaa gaaagaaaag 840atgaaggaga cagaggaggg gtgtaaccag
aaaggtgcgt tcctcgtaga gaagacatct 900accgaagtcc aatgcaaagg
cgggaatgtc tgcgtgcaag ctcaggatcg ctattacaat 960tcctcgtgca
gcaagtgggc atgtgttccc tgcagggtcc gatccggtgg cggtggctcg
1020ggcggtggtg ggtcgggtgg cggcggatcc agggtcattc cagtctctgg
acctgccagg 1080tgtcttagcc agtcccgaaa cctgctgaag accacagatg
acatggtgaa gacggccaga 1140gaaaaactga aacattattc ctgcactgct
gaagacatcg atcatgaaga catcacacgg 1200gaccaaacca gcacattgaa
gacctgttta ccactggaac tacacaagaa cgagagttgc 1260ctggctacta
gagagacttc ttccacaaca agagggagct gcctgccccc acagaagacg
1320tctttgatga tgaccctgtg ccttggtagc atctatgagg acttgaagat
gtaccagaca 1380gagttccagg ccatcaacgc agcacttcag aatcacaacc
atcagcagat cattctagac 1440aagggcatgc tggtggccat cgatgagctg
atgcagtctc tgaatcataa tggcgagact 1500ctgcgccaga aacctcctgt
gggagaagca gacccttaca gagtgaaaat gaagctctgc 1560atcctgcttc
acgccttcag cacccgcgtc gtgaccatca acagggtgat gggctatctg
1620agctccgcct ga 163212532PRTArtificialFhIL-12 fusion polypeptide
12Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu1
5 10 15Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr
Val 20 25 30Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val
Val Leu 35 40 45Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr
Leu Asp Gln 50 55 60Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr
Ile Gln Val Lys65 70 75 80Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys
His Lys Gly Gly Glu Val 85 90 95Leu Ser His Ser Leu Leu Leu Leu His
Lys Lys Glu Asp Gly Ile Trp 100 105 110Ser Thr Asp Ile Leu Lys Asp
Gln Lys Glu Pro Lys Asn Lys Thr Phe 115 120 125Leu Arg Cys Glu Ala
Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 130 135 140Leu Thr Thr
Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg145 150 155
160Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser
165 170 175Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser
Val Glu 180 185 190Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu
Ser Leu Pro Ile 195 200 205Glu Val Met Val Asp Ala Val His Lys Leu
Lys Tyr Glu Asn Tyr Thr 210 215 220Ser Ser Phe Phe Ile Arg Asp Ile
Ile Lys Pro Asp Pro Pro Asn Asn225 230 235 240Leu Gln Leu Lys Pro
Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 245 250 255Glu Tyr Pro
Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 260 265 270Phe
Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 275 280
285Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala
290 295 300Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser
Trp Ser305 310 315 320Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly
Gly Gly Gly Ser Arg 325 330 335Asn Leu Pro Val Ala Thr Pro Asp Pro
Gly Met Phe Pro Cys Leu His 340 345 350His Ser Gln Asn Leu Leu Arg
Ala Val Ser Asn Met Leu Gln Lys Ala 355 360 365Arg Gln Thr Leu Glu
Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 370 375 380Glu Asp Ile
Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro385 390 395
400Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser
405 410 415Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser
Phe Met 420 425 430Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu
Lys Met Tyr Gln 435 440 445Val Glu Phe Lys Thr Met Asn Ala Lys Leu
Leu Met Asp Pro Lys Arg 450 455 460Gln Ile Phe Leu Asp Gln Asn Met
Leu Ala Val Ile Asp Glu Leu Met465 470 475 480Gln Ala Leu Asn Phe
Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 485 490 495Glu Glu Pro
Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 500 505 510His
Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 515 520
525Leu Asn Ala Ser 530131599DNAArtificialFhIL-12 fusion polypeptide
encoding sequence 13atgtgtcacc agcagttggt catctcttgg ttttccctgg
tttttctggc atctcccctc 60gtggccatat gggaactgaa gaaagatgtt tatgtcgtag
aattggattg gtatccggat 120gcccctggag aaatggtggt cctcacctgt
gacacccctg aagaagatgg tatcacctgg 180accttggacc agagcagtga
ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa 240gagtttggag
atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg
300ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt
aaaggaccag 360aaagaaccca aaaataagac ctttctaaga tgcgaggcca
agaattattc tggacgtttc 420acctgctggt ggctgacgac aatcagtact
gatttgacat tcagtgtcaa aagcagcaga 480ggctcttctg acccccaagg
ggtgacgtgc ggagctgcta cactctctgc agagagagtc 540agaggggaca
acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca
600gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa
gctcaagtat 660gaaaactaca ccagcagctt cttcatcagg gacatcatca
aacctgaccc acccaacaac 720ttgcagctga agccattaaa gaattctcgg
caggtggagg tcagctggga gtaccctgac 780acctggagta ctccacattc
ctacttctcc ctgacattct gcgttcaggt ccagggcaag 840agcaagagag
aaaagaaaga tagagtcttc accgacaaga cctcagccac ggtcatctgc
900cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc
atcttggagc 960gaatgggcat ctgtgccctg cagtggtggc ggtggcggcg
gatctagaaa cctccccgtg 1020gccactccag acccaggaat gttcccatgc
cttcaccact cccaaaacct gctgagggcc 1080gtcagcaaca tgctccagaa
ggccagacaa actctagaat tttacccttg cacttctgaa 1140gagattgatc
atgaagatat cacaaaagat aaaaccagca cagtggaggc ctgtttacca
1200ttggaattaa ccaagaatga gagttgccta aattccagag agacctcttt
cataactaat 1260gggagttgcc tggcctccag aaagacctct tttatgatgg
ccctgtgcct tagtagtatt 1320tatgaagact tgaagatgta ccaggtggag
ttcaagacca tgaatgcaaa gcttctgatg 1380gatcctaaga ggcagatctt
tctagatcaa aacatgctgg cagttattga tgagctgatg 1440caggccctga
atttcaacag tgagactgtg ccacaaaaat cctcccttga agaaccggat
1500ttttataaaa ctaaaatcaa gctctgcata cttcttcatg ctttcagaat
tcgggcagtg 1560actattgata gagtgatgag ctatctgaat gcttcctag
15991417628DNAArtificialartificial polynucleotide encoding
Edmonston B MV encoding a murine IL12 fusion protein 14accaaacaaa
gttgggtaag gatagttcaa tcaatgatca tcttctagtg cacttaggat 60tcaagatcct
attatcaggg acaagagcag gattagggat atccgagatg gccacacttt
120taaggagctt agcattgttc aaaagaaaca aggacaaacc acccattaca
tcaggatccg 180gtggagccat cagaggaatc aaacacatta ttatagtacc
aatccctgga gattcctcaa 240ttaccactcg atccagactt ctggaccggt
tggtcaggtt aattggaaac ccggatgtga 300gcgggcccaa actaacaggg
gcactaatag gtatattatc cttatttgtg gagtctccag 360gtcaattgat
tcagaggatc accgatgacc ctgacgttag cataaggctg ttagaggttg
420tccagagtga ccagtcacaa tctggcctta ccttcgcatc aagaggtacc
aacatggagg 480atgaggcgga ccaatacttt tcacatgatg atccaattag
tagtgatcaa tccaggttcg 540gatggttcga gaacaaggaa atctcagata
ttgaagtgca agaccctgag ggattcaaca 600tgattctggg taccatccta
gcccaaattt gggtcttgct cgcaaaggcg gttacggccc 660cagacacggc
agctgattcg gagctaagaa ggtggataaa gtacacccaa caaagaaggg
720tagttggtga atttagattg gagagaaaat ggttggatgt ggtgaggaac
aggattgccg 780aggacctctc cttacgccga ttcatggtcg ctctaatcct
ggacatcaag agaacacccg 840gaaacaaacc caggattgct gaaatgatat
gtgacattga tacatatatc gtagaggcag 900gattagccag ttttatcctg
actattaagt ttgggataga aactatgtat cctgctcttg 960gactgcatga
atttgctggt gagttatcca cacttgagtc cttgatgaac ctttaccagc
1020aaatggggga aactgcaccc tacatggtaa tcctggagaa ctcaattcag
aacaagttca 1080gtgcaggatc ataccctctg ctctggagct atgccatggg
agtaggagtg gaacttgaaa 1140actccatggg aggtttgaac tttggccgat
cttactttga tccagcatat tttagattag 1200ggcaagagat ggtaaggagg
tcagctggaa aggtcagttc cacattggca tctgaactcg 1260gtatcactgc
cgaggatgca aggcttgttt cagagattgc aatgcatact actgaggaca
1320agatcagtag agcggttgga cccagacaag cccaagtatc atttctacac
ggtgatcaaa 1380gtgagaatga gctaccgaga ttggggggca aggaagatag
gagggtcaaa cagagtcgag 1440gagaagccag ggagagctac agagaaaccg
ggcccagcag agcaagtgat gcgagagctg 1500cccatcttcc aaccggcaca
cccctagaca ttgacactgc atcggagtcc agccaagatc 1560cgcaggacag
tcgaaggtca gctgacgccc tgcttaggct gcaagccatg gcaggaatct
1620cggaagaaca aggctcagac acggacaccc ctatagtgta caatgacaga
aatcttctag 1680actaggtgcg agaggccgag gaccagaaca acatccgcct
accctccatc attgttataa 1740aaaacttagg aaccaggtcc acacagccgc
cagcccatca accatccact cccacgattg 1800gagcagatgg cagaagagca
ggcacgccat gtcaaaaacg gactggaatg catccgggct 1860ctcaaggccg
agcccatcgg ctcactggcc atcgaggaag ctatggcagc atggtcagaa
1920atatcagaca acccaggaca ggagcgagcc acctgcaggg aagagaaggc
aggcagttcg 1980ggtctcagca aaccatgcct ctcagcaatt ggatcaactg
aaggcggtgc acctcgcatc 2040cgcggtcagg gacctggaga gagcgatgac
gacgctgaaa ctttgggaat ccccccaaga 2100aatctccagg catcaagcac
tgggctacag tgtcattatg tttatgatca cagcggtgaa 2160gcggttaagg
gaatccaaga tgctgactct atcatggttc aatcaggcct tgatggtgat
2220agcaccctct caggaggaga caatgaatct gaaaacagcg atgtggatat
tggcgaacct 2280gataccgagg gatatgctat cactgaccgg ggatctgctc
ccatctctat ggggttcagg 2340gcttctgatg ttgaaactgc agaaggaggg
gagatccacg agctcctgag actccaatcc 2400agaggcaaca actttccgaa
gcttgggaaa actctcaatg ttcctccgcc cccggacccc 2460ggtagggcca
gcacttccgg gacacccatt aaaaagggca cagacgcgag attagcctca
2520tttggaacgg agatcgcgtc ttcattgaca ggtggtgcaa cccaatgtgc
tcgaaagtca 2580ccctcggaac catcagggcc aggtgcacct gcggggaacg
tccccgagtg tgtgagcaat 2640gccgcactga tacaggagtg gacacccgaa
tctggcacca caatctcccc gagatcccag 2700aataatgaag aagggggaga
ccattatgat gatgagctgt tctctgatgt ccaagatatt 2760aaaacagcct
tggccaaaat acacgaggat aatcagaaga taatctccaa
gctagaatca 2820ctgctgttat tgaagggaga agttgagtca attaagaagc
agatcaacag gcaaaatatc 2880agcatatcca ccctggaagg acacctctca
agcatcatga tcgccattcc tggacttggg 2940aaggatccca acgaccccac
tgcagatgtc gaaatcaatc ccgacttgaa acccatcata 3000ggcagagatt
caggccgagc actggccgaa gttctcaaga aacccgttgc cagccgacaa
3060ctccaaggaa tgacaaatgg acggaccagt tccagaggac agctgctgaa
ggaatttcag 3120ctaaagccga tcgggaaaaa gatgagctca gccgtcgggt
ttgttcctga caccggccct 3180gcatcacgca gtgtaatccg ctccattata
aaatccagcc ggctagagga ggatcggaag 3240cgttacctga tgactctcct
tgatgatatc aaaggagcca atgatcttgc caagttccac 3300cagatgctgg
tgaagataat aatgaagtag ctacagctca acttacctgc caaccccatg
3360ccagtcgacc caactagcgt acacaaccta aatccattat aaaaaactta
ggaaccaggt 3420ccacacactc gagtcgcgcg tggccaccat gtgtcctcag
aagctaacca tctcctggtt 3480tgccatcgtt ttgctggtgt ccccactcat
ggccatgtgg gagctggaga aagacgttta 3540tgttgtagag gtggactgga
ctcccgatgc ccctggagaa acagtgaacc tcacctgtga 3600cacgcctgaa
gaagatgaca tcacctggac ctcagaccag agacatggag tcataggctc
3660tggaaagacc ctgaccatca ctgtcaaaga gtttctagat gctggccagt
acacctgcca 3720caaaggaggc gagactctga gccactcaca tctgctgctc
cacaagaagg aaaatggaat 3780ttggtccact gaaattttaa aaaatttcaa
aaacaagact ttcctgaagt gtgaagcacc 3840aaattactcc ggacggttca
cgtgctcatg gctggtgcaa agaaacatgg acttgaagtt 3900caacatcaag
agcagtagca gttcccctga ctctcgggca gtgacatgtg gaatggcgtc
3960tctgtctgca gagaaggtca cactggacca aagggactat gagaagtatt
cagtgtcctg 4020ccaggaggat gtcacctgcc caactgccga ggagaccctg
cccattgaac tggcgttgga 4080agcacggcag cagaataaat atgagaacta
cagcaccagc ttcttcatca gggacatcat 4140caaaccagac ccgcccaaga
acttgcagat gaagcctttg aagaactcac aggtggaggt 4200cagctgggag
taccctgact cctggagcac tccccattcc tacttctccc tcaagttctt
4260tgttcgaatc cagcgcaaga aagaaaagat gaaggagaca gaggaggggt
gtaaccagaa 4320aggtgcgttc ctcgtagaga agacatctac cgaagtccaa
tgcaaaggcg ggaatgtctg 4380cgtgcaagct caggatcgct attacaattc
ctcgtgcagc aagtgggcat gtgttccctg 4440cagggtccga tccggtggcg
gtggctcggg cggtggtggg tcgggtggcg gcggatccag 4500ggtcattcca
gtctctggac ctgccaggtg tcttagccag tcccgaaacc tgctgaagac
4560cacagatgac atggtgaaga cggccagaga aaaactgaaa cattattcct
gcactgctga 4620agacatcgat catgaagaca tcacacggga ccaaaccagc
acattgaaga cctgtttacc 4680actggaacta cacaagaacg agagttgcct
ggctactaga gagacttctt ccacaacaag 4740agggagctgc ctgcccccac
agaagacgtc tttgatgatg accctgtgcc ttggtagcat 4800ctatgaggac
ttgaagatgt accagacaga gttccaggcc atcaacgcag cacttcagaa
4860tcacaaccat cagcagatca ttctagacaa gggcatgctg gtggccatcg
atgagctgat 4920gcagtctctg aatcataatg gcgagactct gcgccagaaa
cctcctgtgg gagaagcaga 4980cccttacaga gtgaaaatga agctctgcat
cctgcttcac gccttcagca cccgcgtcgt 5040gaccatcaac agggtgatgg
gctatctgag ctccgcctga taatagcgcg cgtcgtacga 5100tgacgtccta
gtacaaccta aatccattat aaaaaactta ggagcaaagt gattgcctcc
5160caagttccac aatgacagag atctacgact tcgacaagtc ggcatgggac
atcaaagggt 5220cgatcgctcc gatacaaccc accacctaca gtgatggcag
gctggtgccc caggtcagag 5280tcatagatcc tggtctaggc gacaggaagg
atgaatgctt tatgtacatg tttctgctgg 5340gggttgttga ggacagcgat
tccctagggc ctccaatcgg gcgagcattt gggtccctgc 5400ccttaggtgt
tggcagatcc acagcaaagc ccgaaaaact cctcaaagag gccactgagc
5460ttgacatagt tgttagacgt acagcagggc tcaatgaaaa actggtgttc
tacaacaaca 5520ccccactaac tctcctcaca ccttggagaa aggtcctaac
aacagggagt gtcttcaacg 5580caaaccaagt gtgcaatgcg gttaatctga
taccgctcga taccccgcag aggttccgtg 5640ttgtttatat gagcatcacc
cgtctttcgg ataacgggta ttacaccgtt cctggaagaa 5700tgctggaatt
cagatcggtc aatgcagtgg ccttcaacct gctggtgacc cttaggattg
5760acaaggcgat aggccctggg aagatcatcg acaatacaga gcaacttcct
gaggcaacat 5820ttatggtcca catcgggaac ttcaggagaa agaagagtga
agtctactct gccgattatt 5880gcaaaatgaa aatcgaaaag atgggcctgg
tttttgcact tggtgggata gggggcacca 5940gtcttcacat tagaagcaca
ggcaaaatga gcaagactct ccatgcacaa ctcgggttca 6000agaagacctt
atgttacccg ctgatggata tcaatgaaga ccttaatcga ttactctgga
6060ggagcagatg caagatagta agaatccagg cagttttgca gccatcagtt
cctcaagaat 6120tccgcattta cgacgacgtg atcataaatg atgaccaagg
actattcaaa gttctgtaga 6180ccgtagtgcc cagcaatgcc cgaaaacgac
ccccctcaca atgacagcca gaaggcccgg 6240acaaaaaagc cccctccgaa
agactccacg gaccaagcga gaggccagcc agcagccgac 6300ggcaagcgcg
aacaccaggc ggccccagca cagaacagcc ctgacacaag gccaccacca
6360gccaccccaa tctgcatcct cctcgtggga cccccgagga ccaaccccca
aggctgcccc 6420cgatccaaac caccaaccgc atccccacca cccccgggaa
agaaaccccc agcaattgga 6480aggcccctcc ccctcttcct caacacaaga
actccacaac cgaaccgcac aagcgaccga 6540ggtgacccaa ccgcaggcat
ccgactccct agacagatcc tctctccccg gcaaactaaa 6600caaaacttag
ggccaaggaa catacacacc caacagaacc cagaccccgg cccacggcgc
6660cgcgccccca acccccgaca accagaggga gcccccaacc aatcccgccg
gctcccccgg 6720tgcccacagg cagggacacc aacccccgaa cagacccagc
acccaaccat cgacaatcca 6780agacgggggg gcccccccaa aaaaaggccc
ccaggggccg acagccagca ccgcgaggaa 6840gcccacccac cccacacacg
accacggcaa ccaaaccaga acccagacca ccctgggcca 6900ccagctccca
gactcggcca tcaccccgca gaaaggaaag gccacaaccc gcgcacccca
6960gccccgatcc ggcggggagc cacccaaccc gaaccagcac ccaagagcga
tccccgaagg 7020acccccgaac cgcaaaggac atcagtatcc cacagcctct
ccaagtcccc cggtctcctc 7080ctcttctcga agggaccaaa agatcaatcc
accacacccg acgacactca actccccacc 7140cctaaaggag acaccgggaa
tcccagaatc aagactcatc caatgtccat catgggtctc 7200aaggtgaacg
tctctgccat attcatggca gtactgttaa ctctccaaac acccaccggt
7260caaatccatt ggggcaatct ctctaagata ggggtggtag gaataggaag
tgcaagctac 7320aaagttatga ctcgttccag ccatcaatca ttagtcataa
aattaatgcc caatataact 7380ctcctcaata actgcacgag ggtagagatt
gcagaataca ggagactact gagaacagtt 7440ttggaaccaa ttagagatgc
acttaatgca gtgacccaga atataagacc ggttcagagt 7500gtagcttcaa
gtaggagaca caagagattt gcgggagtag tcctggcagg tgcggcccta
7560ggcgttgcca cagctgctca gataacagcc ggcattgcac ttcaccagtc
catgctgaac 7620tctcaagcca tcgacaatct gagagcgagc ctggaaacta
ctaatcaggc aattgaggca 7680atcagacaag cagggcagga gatgatattg
gctgttcagg gtgtccaaga ctacatcaat 7740aatgagctga taccgtctat
gaaccaacta tcttgtgatt taatcggcca gaagctcggg 7800ctcaaattgc
tcagatacta tacagaaatc ctgtcattat ttggccccag cttacgggac
7860cccatatctg cggagatatc tatccaggct ttgagctatg cgcttggagg
agacatcaat 7920aaggtgttag aaaagctcgg atacagtgga ggtgatttac
tgggcatctt agagagcaga 7980ggaataaagg cccggataac tcacgtcgac
acagagtcct acttcattgt cctcagtata 8040gcctatccga cgctgtccga
gattaagggg gtgattgtcc accggctaga gggggtctcg 8100tacaacatag
gctctcaaga gtggtatacc actgtgccca agtatgttgc aacccaaggg
8160taccttatct cgaattttga tgagtcatcg tgtactttca tgccagaggg
gactgtgtgc 8220agccaaaatg ccttgtaccc gatgagtcct ctgctccaag
aatgcctccg ggggtccacc 8280aagtcctgtg ctcgtacact cgtatccggg
tcttttggga accggttcat tttatcacaa 8340gggaacctaa tagccaattg
tgcatcaatc ctttgcaagt gttacacaac aggaacgatc 8400attaatcaag
accctgacaa gatcctaaca tacattgctg ccgatcactg cccggtagtc
8460gaggtgaacg gcgtgaccat ccaagtcggg agcaggaggt atccagacgc
tgtgtacttg 8520cacagaattg acctcggtcc tcccatatca ttggagaggt
tggacgtagg gacaaatctg 8580gggaatgcaa ttgctaagtt ggaggatgcc
aaggaattgt tggagtcatc ggaccagata 8640ttgaggagta tgaaaggttt
atcgagcact agcatagtct acatcctgat tgcagtgtgt 8700cttggagggt
tgatagggat ccccgcttta atatgttgct gcagggggcg ttgtaacaaa
8760aagggagaac aagttggtat gtcaagacca ggcctaaagc ctgatcttac
gggaacatca 8820aaatcctatg taaggtcgct ctgatcctct acaactcttg
aaacacaaat gtcccacaag 8880tctcctcttc gtcatcaagc aaccaccgca
cccagcatca agcccacctg aaattatctc 8940cggtttccct ctggccgaac
aatatcggta gttaattaaa acttagggtg caagatcatc 9000cacaatgtca
ccacaacgag accggataaa tgccttctac aaagataacc cccatcccaa
9060gggaagtagg atagtcatta acagagaaca tcttatgatt gatagacctt
atgttttgct 9120ggctgttctg tttgtcatgt ttctgagctt gatcgggttg
ctagccattg caggcattag 9180acttcatcgg gcagccatct acaccgcaga
gatccataaa agcctcagca ccaatctaga 9240tgtaactaac tcaatcgagc
atcaggtcaa ggacgtgctg acaccactct tcaaaatcat 9300cggtgatgaa
gtgggcctga ggacacctca gagattcact gacctagtga aattcatctc
9360tgacaagatt aaattcctta atccggatag ggagtacgac ttcagagatc
tcacttggtg 9420tatcaacccg ccagagagaa tcaaattgga ttatgatcaa
tactgtgcag atgtggctgc 9480tgaagagctc atgaatgcat tggtgaactc
aactctactg gagaccagaa caaccaatca 9540gttcctagct gtctcaaagg
gaaactgctc agggcccact acaatcagag gtcaattctc 9600aaacatgtcg
ctgtccctgt tagacttgta tttaggtcga ggttacaatg tgtcatctat
9660agtcactatg acatcccagg gaatgtatgg gggaacttac ctagtggaaa
agcctaatct 9720gagcagcaaa aggtcagagt tgtcacaact gagcatgtac
cgagtgtttg aagtaggtgt 9780tatcagaaat ccgggtttgg gggctccggt
gttccatatg acaaactatc ttgagcaacc 9840agtcagtaat gatctcagca
actgtatggt ggctttgggg gagctcaaac tcgcagccct 9900ttgtcacggg
gaagattcta tcacaattcc ctatcaggga tcagggaaag gtgtcagctt
9960ccagctcgtc aagctaggtg tctggaaatc cccaaccgac atgcaatcct
gggtcccctt 10020atcaacggat gatccagtga tagacaggct ttacctctca
tctcacagag gtgttatcgc 10080tgacaaccaa gcaaaatggg ctgtcccgac
aacacgaaca gatgacaagt tgcgaatgga 10140gacatgcttc caacaggcgt
gtaagggtaa aatccaagca ctctgcgaga atcccgagtg 10200ggcaccattg
aaggataaca ggattccttc atacggggtc ttgtctgttg atctgagtct
10260gacagttgag cttaaaatca aaattgcttc gggattcggg ccattgatca
cacacggttc 10320agggatggac ctatacaaat ccaaccacaa caatgtgtat
tggctgacta tcccgccaat 10380gaagaaccta gccttaggtg taatcaacac
attggagtgg ataccgagat tcaaggttag 10440tccctacctc ttcactgtcc
caattaagga agcaggcgga gactgccatg ccccaacata 10500cctacctgcg
gaggtggatg gtgatgtcaa actcagttcc aatctggtga ttctacctgg
10560tcaagatctc caatatgttt tggcaaccta cgatacttcc agggttgaac
atgctgtggt 10620ttattacgtt tacagcccaa gccgctcatt ttcttacttt
tatcctttta ggttgcctat 10680aaagggggtc cccatcgaat tacaagtgga
atgcttcaca tgggaccaaa aactctggtg 10740ccgtcacttc tgtgtgcttg
cggactcaga atctggtgga catatcactc actctgggat 10800ggtgggcatg
ggagtcagct gcacagtcac ccgggaagat ggaaccaatc gcagataggg
10860ctgctagtga accaatcaca tgatgtcacc cagacatcag gcatacccac
tagtgtgaaa 10920tagacatcag aattaagaaa aacgtagggt ccaagtggtt
ccccgttatg gactcgctat 10980ctgtcaacca gatcttatac cctgaagttc
acctagatag cccgatagtt accaataaga 11040tagtagccat cctggagtat
gctcgagtcc ctcacgctta cagcctggag gaccctacac 11100tgtgtcagaa
catcaagcac cgcctaaaaa acggattttc caaccaaatg attataaaca
11160atgtggaagt tgggaatgtc atcaagtcca agcttaggag ttatccggcc
cactctcata 11220ttccatatcc aaattgtaat caggatttat ttaacataga
agacaaagag tcaacgagga 11280agatccgtga actcctcaaa aaggggaatt
cgctgtactc caaagtcagt gataaggttt 11340tccaatgctt aagggacact
aactcacggc ttggcctagg ctccgaattg agggaggaca 11400tcaaggagaa
agttattaac ttgggagttt acatgcacag ctcccagtgg tttgagccct
11460ttctgttttg gtttacagtc aagactgaga tgaggtcagt gattaaatca
caaacccata 11520cttgccatag gaggagacac acacctgtat tcttcactgg
tagttcagtt gagttgctaa 11580tctctcgtga ccttgttgct ataatcagta
aagagtctca acatgtatat tacctgacat 11640ttgaactggt tttgatgtat
tgtgatgtca tagaggggag gttaatgaca gagaccgcta 11700tgactattga
tgctaggtat acagagcttc taggaagagt cagatacatg tggaaactga
11760tagatggttt cttccctgca ctcgggaatc caacttatca aattgtagcc
atgctggagc 11820ctctttcact tgcttacctg cagctgaggg atataacagt
agaactcaga ggtgctttcc 11880ttaaccactg ctttactgaa atacatgatg
ttcttgacca aaacgggttt tctgatgaag 11940gtacttatca tgagttaatt
gaagctctag attacatttt cataactgat gacatacatc 12000tgacagggga
gattttctca tttttcagaa gtttcggcca ccccagactt gaagcagtaa
12060cggctgctga aaatgttagg aaatacatga atcagcctaa agtcattgtg
tatgagactc 12120tgatgaaagg tcatgccata ttttgtggaa tcataatcaa
cggctatcgt gacaggcacg 12180gaggcagttg gccaccgctg accctccccc
tgcatgctgc agacacaatc cggaatgctc 12240aagcttcagg tgatgggtta
acacatgagc agtgcgttga taactggaaa tcttttgctg 12300gagtgaaatt
tggctgcttt atgcctctta gcctggatag tgatctgaca atgtacctaa
12360aggacaaggc acttgctgct ctccaaaggg aatgggattc agtttacccg
aaagagttcc 12420tgcgttacga ccctcccaag ggaaccgggt cacggaggct
tgtagatgtt ttccttaatg 12480attcgagctt tgacccatat gatgtgataa
tgtatgttgt aagtggagct tacctccatg 12540accctgagtt caacctgtct
tacagcctga aagaaaagga gatcaaggaa acaggtagac 12600tttttgctaa
aatgacttac aaaatgaggg catgccaagt gattgctgaa aatctaatct
12660caaacgggat tggcaaatat tttaaggaca atgggatggc caaggatgag
cacgatttga 12720ctaaggcact ccacactcta gctgtctcag gagtccccaa
agatctcaaa gaaagtcaca 12780ggggggggcc agtcttaaaa acctactccc
gaagcccagt ccacacaagt accaggaacg 12840tgagagcagc aaaagggttt
atagggttcc ctcaagtaat tcggcaggac caagacactg 12900atcatccgga
gaatatggaa gcttacgaga cagtcagtgc atttatcacg actgatctca
12960agaagtactg ccttaattgg agatatgaga ccatcagctt gtttgcacag
aggctaaatg 13020agatttacgg attgccctca tttttccagt ggctgcataa
gaggcttgag acctctgtcc 13080tgtatgtaag tgaccctcat tgcccccccg
accttgacgc ccatatcccg ttatataaag 13140tccccaatga tcaaatcttc
attaagtacc ctatgggagg tatagaaggg tattgtcaga 13200agctgtggac
catcagcacc attccctatc tatacctggc tgcttatgag agcggagtaa
13260ggattgcttc gttagtgcaa ggggacaatc agaccatagc cgtaacaaaa
agggtaccca 13320gcacatggcc ctacaacctt aagaaacggg aagctgctag
agtaactaga gattactttg 13380taattcttag gcaaaggcta catgatattg
gccatcacct caaggcaaat gagacaattg 13440tttcatcaca tttttttgtc
tattcaaaag gaatatatta tgatgggcta cttgtgtccc 13500aatcactcaa
gagcatcgca agatgtgtat tctggtcaga gactatagtt gatgaaacaa
13560gggcagcatg cagtaatatt gctacaacaa tggctaaaag catcgagaga
ggttatgacc 13620gttaccttgc atattccctg aacgtcctaa aagtgataca
gcaaattctg atctctcttg 13680gcttcacaat caattcaacc atgacccggg
atgtagtcat acccctcctc acaaacaacg 13740acctcttaat aaggatggca
ctgttgcccg ctcctattgg ggggatgaat tatctgaata 13800tgagcaggct
gtttgtcaga aacatcggtg atccagtaac atcatcaatt gctgatctca
13860agagaatgat tctcgcctca ctaatgcctg aagagaccct ccatcaggta
atgacacaac 13920aaccggggga ctcttcattc ctagactggg ctagcgaccc
ttactcagca aatcttgtat 13980gtgtccagag catcactaga ctcctcaaga
acataactgc aaggtttgtc ctgatccata 14040gtccaaaccc aatgttaaaa
ggattattcc atgatgacag taaagaagag gacgagggac 14100tggcggcatt
cctcatggac aggcatatta tagtacctag ggcagctcat gaaatcctgg
14160atcatagtgt cacaggggca agagagtcta ttgcaggcat gctggatacc
acaaaaggct 14220tgattcgagc cagcatgagg aaggggggtt taacctctcg
agtgataacc agattgtcca 14280attatgacta tgaacaattc agagcaggga
tggtgctatt gacaggaaga aagagaaatg 14340tcctcattga caaagagtca
tgttcagtgc agctggcgag agctctaaga agccatatgt 14400gggcgaggct
agctcgagga cggcctattt acggccttga ggtccctgat gtactagaat
14460ctatgcgagg ccaccttatt cggcgtcatg agacatgtgt catctgcgag
tgtggatcag 14520tcaactacgg atggtttttt gtcccctcgg gttgccaact
ggatgatatt gacaaggaaa 14580catcatcctt gagagtccca tatattggtt
ctaccactga tgagagaaca gacatgaagc 14640ttgccttcgt aagagcccca
agtcgatcct tgcgatctgc tgttagaata gcaacagtgt 14700actcatgggc
ttacggtgat gatgatagct cttggaacga agcctggttg ttggctaggc
14760aaagggccaa tgtgagcctg gaggagctaa gggtgatcac tcccatctca
acttcgacta 14820atttagcgca taggttgagg gatcgtagca ctcaagtgaa
atactcaggt acatcccttg 14880tccgagtggc gaggtatacc acaatctcca
acgacaatct ctcatttgtc atatcagata 14940agaaggttga tactaacttt
atataccaac aaggaatgct tctagggttg ggtgttttag 15000aaacattgtt
tcgactcgag aaagataccg gatcatctaa cacggtatta catcttcacg
15060tcgaaacaga ttgttgcgtg atcccgatga tagatcatcc caggataccc
agctcccgca 15120agctagagct gagggcagag ctatgtacca acccattgat
atatgataat gcacctttaa 15180ttgacagaga tgcaacaagg ctatacaccc
agagccatag gaggcacctt gtggaatttg 15240ttacatggtc cacaccccaa
ctatatcaca ttttagctaa gtccacagca ctatctatga 15300ttgacctggt
aacaaaattt gagaaggacc atatgaatga aatttcagct ctcatagggg
15360atgacgatat caatagtttc ataactgagt ttctgctcat agagccaaga
ttattcacta 15420tctacttggg ccagtgtgcg gccatcaatt gggcatttga
tgtacattat catagaccat 15480cagggaaata tcagatgggt gagctgttgt
catcgttcct ttctagaatg agcaaaggag 15540tgtttaaggt gcttgtcaat
gctctaagcc acccaaagat ctacaagaaa ttctggcatt 15600gtggtattat
agagcctatc catggtcctt cacttgatgc tcaaaacttg cacacaactg
15660tgtgcaacat ggtttacaca tgctatatga cctacctcga cctgttgttg
aatgaagagt 15720tagaagagtt cacatttctc ttgtgtgaaa gcgacgagga
tgtagtaccg gacagattcg 15780acaacatcca ggcaaaacac ttatgtgttc
tggcagattt gtactgtcaa ccagggacct 15840gcccaccaat tcaaggtcta
agaccggtag agaaatgtgc agttctaacc gaccatatca 15900aggcagaggc
tatgttatct ccagcaggat cttcgtggaa cataaatcca attattgtag
15960accattactc atgctccctg acttatctcc ggcgaggatc gatcaaacag
ataagattga 16020gagttgatcc aggattcatt ttcgacgccc tcgctgaggt
aaatgtcagt cagccaaaga 16080tcggcagcaa caacatctca aatatgagca
tcaaggcttt cagaccccca cacgatgatg 16140ttgcaaaatt gctcaaagat
atcaacacaa gcaagcacaa tcttcccatt tcagggggca 16200atctcgccaa
ttatgaaatc catgctttcc gcagaatcgg gttgaactca tctgcttgct
16260acaaagctgt tgagatatca acattaatta ggagatgcct tgagccaggg
gaggacggct 16320tgttcttggg tgagggatcg ggttctatgt tgatcactta
taaggagata cttaaactaa 16380gcaagtgctt ctataatagt ggggtttccg
ccaattctag atctggtcaa agggaattag 16440caccctatcc ctccgaagtt
ggccttgtcg aacacagaat gggagtaggt aatattgtca 16500aagtgctctt
taacgggagg cccgaagtca cgtgggtagg cagtgtagat tgcttcaatt
16560tcatagttag taatatccct acctctagtg tggggtttat ccattcagat
atagagacct 16620tgcctgacaa agatactata gagaagctag aggaattggc
agccatctta tcgatggctc 16680tgctcctggg caaaatagga tcaatactgg
tgattaagct tatgcctttc agcggggatt 16740ttgttcaggg atttataagt
tatgtagggt ctcattatag agaagtgaac cttgtatacc 16800ctagatacag
caacttcatc tctactgaat cttatttggt tatgacagat ctcaaggcta
16860accggctaat gaatcctgaa aagattaagc agcagataat tgaatcatct
gtgaggactt 16920cacctggact tataggtcac atcctatcca ttaagcaact
aagctgcata caagcaattg 16980tgggagacgc agttagtaga ggtgatatca
atcctactct gaaaaaactt acacctatag 17040agcaggtgct gatcaattgc
gggttggcaa ttaacggacc taagctgtgc aaagaattga 17100tccaccatga
tgttgcctca gggcaagatg gattgcttaa ttctatactc atcctctaca
17160gggagttggc aagattcaaa gacaaccaaa gaagtcaaca agggatgttc
cacgcttacc 17220ccgtattggt aagtagcagg caacgagaac ttatatctag
gatcacccgc aaattctggg 17280ggcacattct tctttactcc gggaacaaaa
agttgataaa taagtttatc cagaatctca 17340agtccggcta tctgatacta
gacttacacc agaatatctt cgttaagaat ctatccaagt 17400cagagaaaca
gattattatg acggggggtt tgaaacgtga gtgggttttt aaggtaacag
17460tcaaggagac caaagaatgg tataagttag tcggatacag tgccctgatt
aaggactaat 17520tggttgaact ccggaaccct aatcctgccc taggtggtta
ggcattattt gcaatatatt 17580aaagaaaact ttgaaaatac gaagtttcta
ttcccagctt tgtctggt 176281517571DNAArtificialartificial
polynucleotide encoding MV MeVac_H_FhIL-12 15accaaacaaa gttgggtaag
gatagttcaa tcaatgatca tcttctagtg cacttaggat 60tcaagatcct attatcaggg
acaagagcag gattagggat atccgagatg gccacacttt 120taaggagctt
agcattgttc aaaagaaaca aggacaaacc
acccattaca tcaggatccg 180gtggagccat cagaggaatc aaacacatta
ttatagtacc aatccctgga gattcctcaa 240ttaccactcg atccagactt
ctggaccggt tggtgaggtt aattggaaac ccggatgtga 300gcgggcccaa
actaacaggg gcactaatag gtatattatc cttatttgtg gagtctccag
360gtcaattgat tcagaggatc accgatgacc ctgacgttag cataaggctg
ttagaggttg 420tccagagtga ccagtcacaa tctggcctta ccttcgcatc
aagaggtacc aacatggagg 480atgaggcgga ccaatacttt tcacatgatg
atccaattag tagtgatcaa tccaggttcg 540gatggttcgg gaacaaggaa
atctcagata ttgaagtgca agaccctgag ggattcaaca 600tgattctggg
taccatccta gcccaaattt gggtcttgct cgcaaaggcg gttacggccc
660cagacacggc agctgattcg gagctaagaa ggtggataaa gtacacccaa
caaagaaggg 720tagttggtga atttagattg gagagaaaat ggttggatgt
ggtgaggaac aggattgccg 780aggacctctc cttacgccga ttcatggtcg
ctctaatcct ggatatcaag agaacacccg 840gaaacaaacc caggattgct
gaaatgatat gtgacattga tacatatatc gtagaggcag 900gattagccag
ttttatcctg actattaagt ttgggataga aactatgtat cctgctcttg
960gactgcatga atttgctggt gagttatcca cacttgagtc cttgatgaac
ctttaccagc 1020aaatggggga aactgcaccc tacatggtaa tcctggagaa
ctcaattcag aacaagttca 1080gtgcaggatc ataccctctg ctctggagct
atgccatggg agtaggagtg gaacttgaaa 1140actccatggg aggtttgaac
tttggccgat cttactttga tccagcatat tttagattag 1200ggcaagagat
ggtaaggagg tcagctggaa aggtcagttc cacattggca tctgaactcg
1260gtatcactgc cgaggatgca aggcttgttt cagagattgc aatgcatact
actgaggaca 1320agatcagtag agcggttgga cccagacaag cccaagtatc
atttctacac ggtgatcaaa 1380gtgagaatga gctaccgaga ttggggggca
aggaagatag gagggtcaaa cagagtcgag 1440gagaagccag ggagagctac
agagaaaccg ggcccagcag agcaagtgat gcgagagctg 1500cccatcttcc
aaccggcaca cccctagaca ttgacactgc aacggagtcc agccaagatc
1560cgcaggacag tcgaaggtca gctgacgccc tgcttaggct gcaagccatg
gcaggaatct 1620cggaagaaca aggctcagac acggacaccc ctatagtgta
caatgacaga aatcttctag 1680actaggtgcg agaggccgag ggccagaaca
acatccgcct accatccatc attgttataa 1740aaaacttagg aaccaggtcc
acacagccgc cagcccatca accatccact cccacgattg 1800gagccaatgg
cagaagagca ggcacgccat gtcaaaaacg gactggaatg catccgggct
1860ctcaaggccg agcccatcgg ctcactggcc atcgaggaag ctatggcagc
atggtcagaa 1920atatcagaca acccaggaca ggagcgagcc acctgcaggg
aagagaaggc aggcagttcg 1980ggtctcagca aaccatgcct ctcagcaatt
ggatcaactg aaggcggtgc acctcgcatc 2040cgcggtcagg gacctggaga
gagcgatgac gacgctgaaa ctttgggaat ccccccaaga 2100aatctccagg
catcaagcac tgggttacag tgttattacg tttatgatca cagcggtgaa
2160gcggttaagg gaatccaaga tgctgactct atcatggttc aatcaggcct
tgatggtgat 2220agcaccctct caggaggaga caatgaatct gaaaacagcg
atgtggatat tggcgaacct 2280gataccgagg gatatgctat cactgaccgg
ggatctgctc ccatctctat ggggttcagg 2340gcttctgatg ttgaaactgc
agaaggaggg gagatccacg agctcctgag actccaatcc 2400agaggcaaca
actttccgaa gcttgggaaa actctcaatg ttcctccgcc cccggacccc
2460ggtagggcca gcacttccgg gacacccatt aaaaagggca cagacgcgag
attagcctca 2520tttggaacgg agatcgcgtc tttattgaca ggtggtgcaa
cccaatgtgc tcgaaagtca 2580ccctcggaac catcagggcc aggtgcacct
gcggggaatg tccccgagtg tgtgagcaat 2640gccgcactga tacaggagtg
gacacccgaa tctggtacca caatctcccc gagatcccag 2700aataatgaag
aagggggaga ctattatgat gatgagctgt tctctgatgt ccaagatatt
2760aaaacagcct tggccaaaat acacgaggat aatcagaaga taatctccaa
gctagaatca 2820ctgctgttat tgaagggaga agttgagtca attaagaagc
agatcaacag gcaaaatatc 2880agcatatcca ccctggaagg acacctctca
agcatcatga tcgccattcc tggacttggg 2940aaggatccca acgaccccac
tgcagatgtc gaaatcaatc ccgacttgaa acccatcata 3000ggcagagatt
caggccgagc actggccgaa gttctcaaga aacccgttgc cagccgacaa
3060ctccaaggaa tgacaaatgg acggaccagt tccagaggac agctgctgaa
ggaatttcag 3120ctaaagccga tcgggaaaaa gatgagctca gccgtcgggt
ttgttcctga caccggccct 3180gcatcacgca gtgtaatccg ctccattata
aaatccagcc ggctagagga ggatcggaag 3240cgttacctga tgactctcct
tgatgatatc aaaggagcca atgatcttgc caagttccac 3300cagatgctga
tgaagataat aatgaagtag ctacagctca acttacctgc caaccccatg
3360ccagtcgacc caactagtac aacctaaatc cattataaaa aacttaggag
caaagtgatt 3420gcctcccaag gtccacaatg acagagacct acgacttcga
caagtcggca tgggacatca 3480aagggtcgat cgctccgata caacccacca
cctacagtga tggcaggctg gtgccccagg 3540tcagagtcat agatcctggt
ctaggcgaca ggaaggatga atgctttatg tacatgtttc 3600tgctgggggt
tgttgaggac agcgattccc tagggcctcc aatcgggcga gcatttgggt
3660tcctgccctt aggtgttggc agatccacag caaagcccga aaaactcctc
aaagaggcca 3720ctgagcttga catagttgtt agacgtacag cagggctcaa
tgaaaaactg gtgttctaca 3780acaacacccc actaactctc ctcacacctt
ggagaaaggt cctaacaaca gggagtgtct 3840tcaacgcaaa ccaagtgtgc
aatgcggtta atctgatacc gctcgatacc ccgcagaggt 3900tccgtgttgt
ttatatgagc atcacccgtc tttcggataa cgggtattac accgttccta
3960gaagaatgct ggaattcaga tcggtcaatg cagtggcctt caacctgctg
gtgaccctta 4020ggattgacaa ggcgataggc cctgggaaga tcatcgacaa
tacagagcaa cttcctgagg 4080caacatttat ggtccacatc gggaacttca
ggagaaagaa gagtgaagtc tactctgccg 4140attattgcaa aatgaaaatc
gaaaagatgg gcctggtttt tgcacttggt gggatagggg 4200gcaccagtct
tcacattaga agcacaggca aaatgagcaa gactctccat gcacaactcg
4260ggttcaagaa gaccttatgt tacccgctga tggatatcaa tgaagacctt
aatcgattac 4320tctggaggag cagatgcaag atagtaagaa tccaggcagt
tttgcagcca tcagttcctc 4380aagaattccg catttacgac gacgtgatca
taaatgatga ccaaggacta ttcaaagttc 4440tgtagaccgt agtgcccagc
aatgcccgaa aacgaccccc ctcacaatga cagccagaag 4500gcccggacaa
aaaagccccc tccgaaagac tccacggacc aagcgagagg ccagccagca
4560gccgacggca agcgcgaaca ccaggcggcc ccagcacaga acagccctga
cacaaggcca 4620ccaccagcca ccccaatctg catcctcctc gtgggacccc
cgaggaccaa cccccaaggc 4680tgcccccgat ccaaaccacc aaccgcatcc
ccaccacccc cgggaaagaa acccccagca 4740attggaaggc ccctccccct
cttcctcaac acaagaactc cacaaccgaa ccgcacaagc 4800gaccgaggtg
acccaaccgc aggcatccga ctccctagac agatcctctc tccccggcaa
4860actaaacaaa acttagggcc aaggaacata cacacccaac agaacccaga
ccccggccca 4920cggcgccgcg cccccaaccc ccgacaacca gagggagccc
ccaaccaatc ccgccggctc 4980ccccggtgcc cacaggcagg gacaccaacc
cccgaacaga cccagcaccc aaccatcgac 5040aatccaagac gggggggccc
ccccaaaaaa aggcccccag gggccgacag ccagcaccgc 5100gaggaagccc
acccacccca cacacgacca cggcaaccaa accagaaccc agaccaccct
5160gggccaccag ctcccagact cggccatcac cccgcagaaa ggaaaggcca
caacccgcgc 5220accccagccc cgatccggcg gggagccacc caacccgaac
cagcacccaa gagcgatccc 5280cgaaggaccc ccgaaccgca aaggacatca
gtatcccaca gcctctccaa gtcccccggt 5340ctcctcctct tctcgaaggg
accaaaagat caatccacca cacccgacga cactcaactc 5400cccaccccta
aaggagacac cgggaatccc agaatcaaga ctcatccaat gtccatcatg
5460ggtctcaagg tgaacgtctc tgccatattc atggcagtac tgttaactct
ccaaacaccc 5520accggtcaaa tccattgggg caatctctct aagatagggg
tggtaggaat aggaagtgca 5580agctacaaag ttatgactcg ttccagccat
caatcattag tcataaaatt aatgcccaat 5640ataactctcc tcaataactg
cacgagggta gagattgcag aatacaggag actactgaga 5700acagttttgg
aaccaattag agatgcactt aatgcaatga cccagaatat aagaccggtt
5760cagagtgtag cttcaagtag gagacacaag agatttgcgg gagtagtcct
ggcaggtgcg 5820gccctaggcg ttgccacagc tgctcagata acagccggca
ttgcacttca ccagtccatg 5880ctgaactctc aagccatcga caatctgaga
gcgagcctgg aaactactaa tcaggcaatt 5940gagacaatca gacaagcagg
gcaggagatg atattggctg ttcagggtgt ccaagactac 6000atcaataatg
agctgatacc gtctatgaac caactatctt gtgatttaat cggccagaag
6060ctcgggctca aattgctcag atactataca gaaatcctgt cattatttgg
ccccagttta 6120cgggacccca tatctgcgga gatatctatc caggctttga
gctatgcgct tggaggagac 6180atcaataagg tgttagaaaa gctcggatac
agtggaggtg atttactggg catcttagag 6240agcggaggaa taaaggcccg
gataactcac gtcgacacag agtcctactt cattgtcctc 6300agtatagcct
atccgacgct gtccgagatt aagggggtga ttgtccaccg gctagagggg
6360gtctcgtaca acataggctc tcaagagtgg tataccactg tgcccaagta
tgttgcaacc 6420caagggtacc ttatctcgaa ttttgatgag tcatcgtgta
ctttcatgcc agaggggact 6480gtgtgcagcc aaaatgcctt gtacccgatg
agtcctctgc tccaagaatg cctccggggg 6540tacaccaagt cctgtgctcg
tacactcgta tccgggtctt ttgggaaccg gttcatttta 6600tcacaaggga
acctaatagc caattgtgca tcaatccttt gcaagtgtta cacaacagga
6660acgatcatta atcaagaccc tgacaagatc ctaacataca ttgctgccga
tcactgcccg 6720gtagtcgagg tgaacggcgt gaccatccaa gtcgggagca
ggaggtatcc agacgctgtg 6780tacttgcaca gaattgacct cggtcctccc
atatcattgg agaggttgga cgtagggaca 6840aatctgggga atgcaattgc
taagttggag gatgccaagg aattgttgga gtcatcggac 6900cagatattga
ggagtatgaa aggtttatcg agcactagca tagtctacat cctgattgca
6960gtgtgtcttg gagggttgat agggatcccc gctttaatat gttgctgcag
ggggcgttgt 7020aacaaaaagg gagaacaagt tggtatgtca agaccaggcc
taaagcctga tcttacggga 7080acatcaaaat cctatgtaag gtcgctctga
tcctctacaa ctcttgaaac acaaatgtcc 7140cacaagtctc ctcttcgtca
tcaagcaacc accgcaccca gcatcaagcc cacctgaaat 7200tatctccggc
ttccctctgg ccgaacaata tcggtagtta atcaaaactt agggtgcaag
7260atcatccaca atgtcaccac aacgagaccg gataaatgcc ttctacaaag
ataaccccca 7320tcccaaggga agtaggatag tcattaacag agaacatctt
atgattgata gaccttatgt 7380tttgctggct gttctgtttg tcatgtttct
gagcttgatc gggttgctag ccattgcagg 7440cattagactt catcgggcag
ccatctacac cgcagagatc cataaaagcc tcagcaccaa 7500tctagatgta
actaactcaa tcgagcatca ggtcaaggac gtgctgacac cactcttcaa
7560aatcatcggt gatgaagtgg gcctgaggac acctcagaga ttcactgacc
tagtgaaatt 7620aatctctgac aagattaaat tccttaatcc ggatagggag
tacgacttca gagatctcac 7680ttggtgtatc aacccgccag agagaatcaa
attggattat gatcaatact gtgcagatgt 7740ggctgctgaa gagctcatga
atgcattggt gaactcaact ctactggaga ccagaacaac 7800caatcagttc
ctagctgtct caaagggaaa ctgctcaggg cccactacaa tcagaggtca
7860attctcaaac atgtcgctgt ccctgttaga cttgtattta ggtcgaggtt
acaatgtgtc 7920atctatagtc actatgacat cccagggaat gtatggggga
acttacctag tggaaaagcc 7980taatctgagc agcaaaaggt cagagttgtc
acaactgagc atgtaccgag tgtttgaagt 8040aggtgttatc agaaatccgg
gtttgggggc tccggtgttc catatgacaa actatcttga 8100gcaaccagtc
agtaatgatc tcagcaactg tatggtggct ttgggggagc tcaaactcgc
8160agccctttgt cacggggaag attctatcac aattccctat cagggatcag
ggaaaggtgt 8220cagcttccag ctcgtcaagc taggtgtctg gaaatcccca
accgacatgc aatcctgggt 8280ccccttatca acggatgatc cagtgataga
caggctttac ctctcatctc acagaggtgt 8340tatcgctgac aatcaagcaa
aatgggctgt cccgacaaca cgaacagatg acaagttgcg 8400aatggagaca
tgcttccaac aggcgtgtaa gggtaaaatc caagcactct gcgagaatcc
8460cgagtgggca ccattgaagg ataacaggat tccttcatac ggggtcttgt
ctgttgatct 8520gagtctgaca gttgagctta aaatcaaaat tgcttcggga
ttcgggccat tgatcacaca 8580cggttcaggg atggacctat acaaatccaa
ccacaacaat gtgtattggc tgactatccc 8640gccaatgaag aacctagcct
taggtgtaat caacacattg gagtggatac cgagattcaa 8700ggttagtccc
tacctcttca ctgtcccaat taaggaagca ggcgaagact gccatgcccc
8760aacataccta cctgcggagg tggatggtga tgtcaaactc agttccaatc
tggtgattct 8820acctggtcaa gatctccaat atgttttggc aacctacgat
acttccaggg ttgaacatgc 8880tgtggtttat tacgtttaca gcccaagccg
ctcattttct tacttttatc cttttaggtt 8940gcctataaag ggggtcccca
tcgaattaca agtggaatgc ttcacatggg accaaaaact 9000ctggtgccgt
cacttctgtg tgcttgcgga ctcagaatct ggtggacata tcactcactc
9060tgggatggtg ggcatgggag tcagctgcac agtcacccgg gaagatggaa
ccaatcgcag 9120atagggctgc tagtgaacca atcacatgat gtcacccaga
catcaggcat acccactagt 9180catccatcat tgttataaaa aacttaggaa
ccaggtccac acagctcgag tcgcgcgtgc 9240caccatgtgt caccagcagt
tggtcatctc ttggttttcc ctggtttttc tggcatctcc 9300cctcgtggcc
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc
9360ggatgcccct ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag
atggtatcac 9420ctggaccttg gaccagagca gtgaggtctt aggctctggc
aaaaccctga ccatccaagt 9480caaagagttt ggagatgctg gccagtacac
ctgtcacaaa ggaggcgagg ttctaagcca 9540ttcgctcctg ctgcttcaca
aaaaggaaga tggaatttgg tccactgata ttttaaagga 9600ccagaaagaa
cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg
9660tttcacctgc tggtggctga cgacaatcag tactgatttg acattcagtg
tcaaaagcag 9720cagaggctct tctgaccccc aaggggtgac gtgcggagct
gctacactct ctgcagagag 9780agtcagaggg gacaacaagg agtatgagta
ctcagtggag tgccaggagg acagtgcctg 9840cccagctgct gaggagagtc
tgcccattga ggtcatggtg gatgccgttc acaagctcaa 9900gtatgaaaac
tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa
9960caacttgcag ctgaagccat taaagaattc tcggcaggtg gaggtcagct
gggagtaccc 10020tgacacctgg agtactccac attcctactt ctccctgaca
ttctgcgttc aggtccaggg 10080caagagcaag agagaaaaga aagatagagt
cttcaccgac aagacctcag ccacggtcat 10140ctgccgcaaa aatgccagca
ttagcgtgcg ggcccaggac cgctactata gctcatcttg 10200gagcgaatgg
gcatctgtgc cctgcagtgg tggcggtggc ggcggatcta gaaacctccc
10260cgtggccact ccagacccag gaatgttccc atgccttcac cactcccaaa
acctgctgag 10320ggccgtcagc aacatgctcc agaaggccag acaaactcta
gaattttacc cttgcacttc 10380tgaagagatt gatcatgaag atatcacaaa
agataaaacc agcacagtgg aggcctgttt 10440accattggaa ttaaccaaga
atgagagttg cctaaattcc agagagacct ctttcataac 10500taatgggagt
tgcctggcct ccagaaagac ctcttttatg atggccctgt gccttagtag
10560tatttatgaa gacttgaaga tgtaccaggt ggagttcaag accatgaatg
caaagcttct 10620gatggatcct aagaggcaga tctttctaga tcaaaacatg
ctggcagtta ttgatgagct 10680gatgcaggcc ctgaatttca acagtgagac
tgtgccacaa aaatcctccc ttgaagaacc 10740ggatttttat aaaactaaaa
tcaagctctg catacttctt catgctttca gaattcgggc 10800agtgactatt
gatagagtga tgagctatct gaatgcttcc taggcgcgcg ttctagtgtg
10860aaatagacat cagaattaag aaaaacgtag ggtccaagtg gttccccgtt
atggactcgc 10920tatctgtcaa ccagatctta taccctgaag ttcacctaga
tagcccgata gttaccaata 10980agatagtagc catcctggag tatgctcgag
tccctcacgc ttacagcctg gaggacccta 11040cactgtgtca gaacatcaag
caccgcctaa aaaacggatt ttccaaccaa atgattataa 11100acaatgtgga
agttgggaat gtcatcaagt ccaagcttag gagttatccg gcccactctc
11160atattccata tccaaattgt aatcaggatt tatttaacat agaagacaaa
gagtcaacga 11220ggaagatccg tgaactcctc aaaaagggga attcgctgta
ctccaaagtc agtgataagg 11280ttttccaatg cttaagggac actaactcac
ggcttggcct aggctccgaa ttgagggagg 11340acatcaagga gaaagttatt
aacttgggag tttacatgca cagctcccag tggtttgagc 11400cctttctgtt
ttggtttaca gtcaagactg agatgaggtc agtgattaaa tcacaaaccc
11460atacttgcca taggaggaga cacacacctg tattcttcac tggtagttca
gttgagttgc 11520taatctctcg tgaccttgtt gctataatca gtaaagagtc
tcaacatgta tattacctga 11580catttgaact ggttttgatg tattgtgatg
tcatagaggg gaggttaatg acagagaccg 11640ctatgactat tgatgctagg
tatacagagc ttctaggaag agtcagatac atgtggaaac 11700tgatagatgg
tttcttccct gcactcggga atccaactta tcaaattgta gccatgctgg
11760agcctctttc acttgcttac ctgcagctga gggatataac agtagaactc
agaggtgctt 11820tccttaacca ctgctttact gaaatacatg atgttcttga
ccaaaacggg ttttctgatg 11880aaggtactta tcatgagtta actgaagctc
tagattacat tttcataact gatgacatac 11940atctgacagg ggagattttc
tcatttttca gaagtttcgg ccaccccaga cttgaagcag 12000taacggctgc
tgaaaatgtt aggaaataca tgaatcagcc taaagtcatt gtgtatgaga
12060ctctgatgaa aggtcatgcc atattttgtg gaatcataat caacggctat
cgtgacaggc 12120acggaggcag ttggccaccg ctgaccctcc ccctgcatgc
tgcagacaca atccggaatg 12180ctcaagcttc aggtgaaggg ttaacacatg
agcagtgcgt tgataactgg aaatcttttg 12240ctggagtgaa atttggctgc
tttatgcctc ttagcctgga tagtgatctg acaatgtacc 12300taaaggacaa
ggcacttgct gctctccaaa gggaatggga ttcagtttac ccgaaagagt
12360tcctgcgtta cgaccctccc aagggaaccg ggtcacggag gcttgtagat
gttttcctta 12420atgattcgag ctttgaccca tatgatgtga taatgtatgt
tgtaagtgga gcttacctcc 12480atgaccctga gttcaacctg tcttacagcc
tgaaagaaaa ggagatcaag gaaacaggta 12540gactttttgc taaaatgact
tacaaaatga gggcatgcca agtgattgct gaaaatctaa 12600tctcaaacgg
gattggcaaa tattttaagg acaatgggat ggccaaggat gagcacgatt
12660tgactaaggc actccacact ctagctgtct caggagtccc caaagatctc
aaagaaagtc 12720acaggggggg gccagtctta aaaacctact cccgaagccc
agtccacaca agtaccagga 12780acgtgagagc agcaaaaggg tttatagggt
tccctcaagt aattcggcag gaccaagaca 12840ctgatcatcc ggagaatatg
gaagcttacg agacagtcag tgcatttatc acgactgatc 12900tcaagaagta
ctgccttaat tggagatatg agaccatcag cttgtttgca cagaggctaa
12960atgagattta cggattgccc tcatttttcc agtggctgca taagaggctt
gagacctctg 13020tcctgtatgt aagtgaccct cattgccccc ccgaccttga
cgcccatatc ccgttatata 13080aagtccccaa tgatcaaatc ttcattaagt
accctatggg aggtatagaa gggtattgtc 13140agaagctgtg gaccatcagc
accattccct atctatacct ggctgcttat gagagcggag 13200taaggattgc
ttcgttagtg caaggggaca atcagaccat agccgtaaca aaaagggtac
13260ccagcacatg gccctacaac cttaagaaac gggaagctgc tagagtaact
agagattact 13320ttgtaattct taggcaaagg ctacatgata ttggccatca
cctcaaggca aatgagacaa 13380ttgtttcatc acattttttt gtctattcaa
aaggaatata ttatgatggg ctacttgtgt 13440cccaatcact caagagcatc
gcaagatgtg tattctggtc agagactata gttgatgaaa 13500caagggcagc
atgcagtaat attgctacaa caatggctaa aagcatcgag agaggttatg
13560accgttacct tgcatattcc ctgaacgtcc taaaagtgat acagcaaatt
ctgatctctc 13620ttggcttcac aatcaattca accatgaccc gggatgtagt
catacccctc ctcacaaaca 13680acgacctctt aataaggatg gcactgttgc
ccgctcctat tggggggatg aattatctga 13740atatgagcag gctgtttgtc
agaaacatcg gtgatccagt aacatcatca attgctgatc 13800tcaagagaat
gattctcgcc tcactaatgc ctgaagagac cctccatcaa gtaatgacac
13860aacaaccggg ggactcttca ttcctagact gggctagcga cccttactca
gcaaatcttg 13920tatgtgtcca gagcatcact agactcctca agaacataac
tgcaaggttt gtcctgatcc 13980atagtccaaa cccaatgtta aaaggattat
tccatgatga cagtaaagaa gaggacgagg 14040gactggcggc attcctcatg
gacaggcata ttatagtacc tagggcagct catgaaatcc 14100tggatcatag
tgtcacaggg gcaagagagt ctattgcagg catgctggat accacaaaag
14160gcttgattcg agccagcatg aggaaggggg ggttaacctc tcgagtgata
accagattgt 14220ccaattatga ctatgaacaa ttcagagcag ggatggtgct
attgacagga agaaagagaa 14280atgtcctcat tgacaaagag tcatgttcag
tgcagctggc gagagctcta agaagccata 14340tgtgggcgag gctagctcga
ggacggccta tttacggcct tgaggtccct gatgtactag 14400aatctatgcg
aggccacctt attcggcgtc atgagacatg tgtcatctgc gagtgtggat
14460cagtcaacta cggatggttt tttgtcccct cgggttgcca actggatgat
attgacaagg 14520aaacatcatc cttgagagtc ccatatattg gttctaccac
tgatgagaga acagacatga 14580agcttgcctt cgtaagagcc ccaagtcgat
ccttgcgatc tgctgttaga atagcaacag 14640tgtactcatg ggcttacggt
gatgatgata gctcttggaa cgaagcctgg ttgttggcta 14700ggcaaagggc
caatgtgagc ctggaggagc taagggtgat cactcccatc tcaacttcga
14760ctaatttagc gcataggttg agggatcgta gcactcaagt gaaatactca
ggtacatccc 14820ttgtccgagt ggcgaggtat accacaatct ccaacgacaa
tctctcattt gtcatatcag 14880ataagaaggt tgatactaac tttatatacc
aacaaggaat gcttctaggg ttgggtgttt 14940tagaaacatt gtttcgactc
gagaaagata ccggatcatc taacacggta ttacatcttc 15000acgtcgaaac
agattgttgc gtgatcccga tgatagatca tcccaggata cccagctccc
15060gcaagctaga gctgagggca gagctatgta ccaacccatt gatatatgat
aatgcacctt 15120taattgacag agatgcaaca aggctataca cccagagcca
taggaggcac cttgtggaat 15180ttgttacatg gtccacaccc caactatatc
acattttagc
taagtccaca gcactatcta 15240tgattgacct ggtaacaaaa tttgagaagg
accatatgaa tgaaatttca gctctcatag 15300gggatgacga tatcaatagt
ttcataactg agtttctgct catagagcca agattattca 15360ctatctactt
gggccagtgt gcggccatca attgggcatt tgatgtacat tatcatagac
15420catcagggaa atatcagatg ggtgagctgt tgtcatcgtt cctttctaga
atgagcaaag 15480gagtgtttaa ggtgcttgtc aatgctctaa gccacccaaa
gatctacaag aaattctggc 15540attgtggtat tatagagcct atccatggtc
cttcacttga tgctcaaaac ttgcacacaa 15600ctgtgtgcaa catggtttac
acatgctata tgacctacct cgacctgttg ttgaatgaag 15660agttagaaga
gttcacattt ctcttgtgtg aaagcgacga ggatgtagta ccggacagat
15720tcgacaacat ccaggcaaaa cacttatgtg ttctggcaga tttgtactgt
caaccaggga 15780cctgcccacc aattcgaggt ctaagaccgg tagagaaatg
tgcagttcta accgaccata 15840tcaaggcaga ggctatgtta tctccagcag
gatcttcgtg gaacataaat ccaattattg 15900tagaccatta ctcatgctct
ctgacttatc tccggcgagg atcgatcaaa cagataagat 15960tgagagttga
tccaggattc attttcgacg ccctcgctga ggtaaatgtc agtcagccaa
16020agatcggcag caacaacatc tcaaatatga gcatcaaggc tttcagaccc
ccacacgatg 16080atgttgcaaa attgctcaaa gatatcaaca caagcaagca
caatcttccc atttcagggg 16140gcaatctcgc caattatgaa atccatgctt
tccgcagaat cgggttgaac tcatctgctt 16200gctacaaagc tgttgagata
tcaacattaa ttaggagatg ccttgagcca ggggaggacg 16260gcttgttctt
gggtgaggga tcgggttcta tgttgatcac ttataaagag atacttaaac
16320taaacaagtg cttctataat agtggggttt ccgccaattc tagatctggt
caaagggaat 16380tagcacccta tccctccgaa gttggccttg tcgaacacag
aatgggagta ggtaatattg 16440tcaaagtgct ctttaacggg aggcccgaag
tcacgtgggt aggcagtgta gattgcttca 16500atttcatagt tagtaatatc
cctacctcta gtgtggggtt tatccattca gatatagaga 16560ccttgcctga
caaagatact atagagaagc tagaggaatt ggcagccatc ttatcgatgg
16620ctctgctcct gggcaaaata ggatcaatac tggtgattaa gcttatgcct
ttcagcgggg 16680attttgttca gggatttata agttatgtag ggtctcatta
tagagaagtg aaccttgtat 16740accctagata cagcaacttc atctctactg
aatcttattt ggttatgaca gatctcaagg 16800ctaaccggct aatgaatcct
gaaaagatta agcagcagat aattgaatca tctgtgagga 16860cttcacctgg
acttataggt cacatcctat ccattaagca actaagctgc atacaagcaa
16920ttgtgggaga cgcagttagt agaggtgata tcaatcctac tctgaaaaaa
cttacaccta 16980tagagcaggt gctgatcaat tgcgggttgg caattaacgg
acctaagctg tgcaaagaat 17040tgatccacca tgatgttgcc tcagggcaag
atggattgct taattctata ctcatcctct 17100acagggagtt ggcaagattc
aaagacaacc aaagaagtca acaagggatg ttccacgctt 17160accccgtatt
ggtaagtagc aggcaacgag aacttatatc taggatcacc cgcaaattct
17220gggggcacat tcttctttac tccgggaaca aaaagttgat aaataagttt
atccagaatc 17280tcaagtccgg ctatctgata ctagacttac accagaatat
cttcgttaag aatctatcca 17340agtcagagaa acagattatt atgacggggg
gtttgaaacg tgagtgggtt tttaaggtaa 17400cagtcaagga gaccaaagaa
tggtataagt tagtcggata cagtgccctg attaaggact 17460aattggttga
actccggaac cctaatcctg ccctaggtgg ttaggcatta tttgcaatat
17520attaaagaaa actttgaaaa tacgaagttt ctattcccag ctttgtctgg t
1757116282PRTArtificialartificial subsequence of IgG1 (Fc) 16Met
Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro1 5 10
15Gly Ser Thr Gly Asp Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ala
20 25 30Gln Pro Ala Val Asp Glu Ala Lys Ser Cys Asp Lys Thr His Thr
Cys 35 40 45Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
Phe Leu 50 55 60Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu65 70 75 80Val Thr Cys Val Val Val Asp Val Ser His Glu
Asp Pro Glu Val Lys 85 90 95Phe Asn Trp Tyr Val Asp Gly Val Glu Val
His Asn Ala Lys Thr Lys 100 105 110Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr Arg Val Val Ser Val Leu 115 120 125Thr Val Leu His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 130 135 140Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys145 150 155 160Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 165 170
175Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
180 185 190Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
Gly Gln 195 200 205Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
Asp Ser Asp Gly 210 215 220Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln225 230 235 240Gln Gly Asn Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn 245 250 255His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Glu 260 265 270Gln Lys Leu
Ile Ser Glu Glu Asp Leu Asn 275 28017852DNAArtificialartificial
sequence encoding IgG1-Fc 17atggagacag acacactcct gctatgggta
ctgctgctct gggttccagg ttccactggt 60gactatccat atgatgttcc agattatgct
ggggcccagc cggccgtcga cgaggccaaa 120tcttgtgaca aaactcacac
atgcccaccg tgcccagcac ccgaactcct ggggggaccg 180tcagtcttcc
tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag
240gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt
caactggtac 300gtggacggcg tggaggtgca taatgccaag acaaagccgc
gggaggagca gtacaacagc 360acgtaccgtg tggtcagcgt cctcaccgtc
ctgcaccagg actggctgaa tggcaaggag 420tacaagtgca aggtctccaa
caaagccctc ccagccccca tcgagaaaac catctccaaa 480gccaaggggc
agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg
540accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag
cgacatcgcc 600gtggagtggg agagcaatgg gcagccggag aacaactaca
agaccacgcc tcccgtgctg 660gactccgacg gctccttctt cctctacagc
aagctcaccg tggacaagag caggtggcag 720caggggaacg tcttctcatg
ctccgtgatg catgaggctc tgcacaacca ctacacgcag 780aagagcctct
ccctgtctcc gggtaaagtc gacgaacaaa aactcatctc agaagaagat
840ctgaattgat ag 852
uspto.report is an independent third-party trademark research tool that is not affiliated, endorsed, or sponsored by the United States Patent and Trademark Office (USPTO) or any other governmental organization. The information provided by uspto.report is based on publicly available data at the time of writing and is intended for informational purposes only.
While we strive to provide accurate and up-to-date information, we do not guarantee the accuracy, completeness, reliability, or suitability of the information displayed on this site. The use of this site is at your own risk. Any reliance you place on such information is therefore strictly at your own risk.
All official trademark data, including owner information, should be verified by visiting the official USPTO website at www.uspto.gov. This site is not intended to replace professional legal advice and should not be used as a substitute for consulting with a legal professional who is knowledgeable about trademark law.