U.S. patent application number 16/145618 was filed with the patent office on 2019-05-23 for dosing regimes for treatment of synucleinopathies. The applicant listed for this patent is F. Hoffmann-La Roche AG, Prothena Biosciences Limited. Invention is credited to Sara Belli, Frank Boess, Valerie Cosson, Ronald Gieschke, Hans Peter Grimm, Martin Koller, Meret Martin-Fracklam, Diane Mould, Daniel Keith Ness, Jay Soto, Silke Weber.
Application Number | 20190153102 16/145618 |
Document ID | / |
Family ID | 66534923 |
Filed Date | 2019-05-23 |
United States Patent Application | 20190153102 |
Kind Code | A1 |
Soto; Jay ; et al. | May 23, 2019 |
The invention provides dosage regimes for treatment of synucleinopathies. In one regime, a subject receives 3000-5000 mg of an antibody intravenously every 3-5 weeks. In another regime, a subject receives 1300-1700 mg of an antibody intravenously every 3-5 weeks.
Inventors: | Soto; Jay; (San Francisco, CA) ; Ness; Daniel Keith; (San Mateo, CA) ; Koller; Martin; (Rancho Santa Fe, CA) ; Mould; Diane; (Fort Myers, FL) ; Boess; Frank; (Basel, CH) ; Martin-Fracklam; Meret; (Basel, CH) ; Cosson; Valerie; (Basel, CH) ; Grimm; Hans Peter; (Basel, CH) ; Gieschke; Ronald; (Basel, CH) ; Belli; Sara; (Basel, CH) ; Weber; Silke; (Basel, CH) | ||||||||||
Applicant: |
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Family ID: | 66534923 | ||||||||||
Appl. No.: | 16/145618 | ||||||||||
Filed: | September 28, 2018 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
62564992 | Sep 28, 2017 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | A61B 5/1101 20130101; A61K 9/0019 20130101; C07K 16/2857 20130101; A61K 2039/545 20130101; A61P 25/16 20180101; A61B 5/11 20130101; A61P 25/28 20180101; A61K 2039/505 20130101; A61B 5/0004 20130101; C07K 16/18 20130101; A61B 5/4082 20130101; A61B 5/4848 20130101; A61K 31/198 20130101 |
International Class: | C07K 16/28 20060101 C07K016/28; A61P 25/28 20060101 A61P025/28; A61P 25/16 20060101 A61P025/16; A61B 5/00 20060101 A61B005/00; A61B 5/11 20060101 A61B005/11; A61K 9/00 20060101 A61K009/00; A61K 31/198 20060101 A61K031/198 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 151 <210> SEQ ID NO 1 <211> LENGTH: 113
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 1 Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu
Ala Val Ser Val Gly 1 5 10 15 Glu Lys Val Thr Met Ser Cys Lys Ser
Ile Gln Thr Leu Leu Tyr Ser 20 25 30 Ser Asn Gln Lys Asn Tyr Leu
Ala Trp Phe Gln Gln Lys Pro Gly Gln 35 40 45 Ser Pro Lys Leu Leu
Ile Tyr Trp Ala Ser Ile Arg Lys Ser Gly Val 50 55 60 Pro Asp Arg
Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile
Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 85 90
95 Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110 Lys <210> SEQ ID NO 2 <211> LENGTH: 107
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 2 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala
Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys
Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser
Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 85 90
95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210>
SEQ ID NO 3 <211> LENGTH: 113 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 3
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5
10 15 Asp Arg Val Thr Ile Thr Cys Lys Ser Ile Gln Thr Leu Leu Tyr
Ser 20 25 30 Ser Asn Gln Lys Asn Tyr Leu Ala Trp Phe Gln Gln Lys
Pro Gly Lys 35 40 45 Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile
Arg Lys Ser Gly Val 50 55 60 Pro Ser Arg Phe Ser Gly Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Pro Glu
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Ser Tyr Pro
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 100 105 110 Lys
<210> SEQ ID NO 4 <211> LENGTH: 113 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 4
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5
10 15 Asp Arg Val Thr Ile Thr Cys Lys Ser Ile Gln Thr Leu Leu Tyr
Ser 20 25 30 Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys
Pro Gly Lys 35 40 45 Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile
Arg Lys Ser Gly Val 50 55 60 Pro Ser Arg Phe Ser Gly Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Pro Glu
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Ser Tyr Pro
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 100 105 110 Lys
<210> SEQ ID NO 5 <211> LENGTH: 113 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 5
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5
10 15 Asp Arg Val Thr Ile Thr Cys Lys Ser Ile Gln Thr Leu Leu Tyr
Ser 20 25 30 Ser Asn Gln Lys Asn Tyr Leu Ala Trp Phe Gln Gln Lys
Pro Gly Lys 35 40 45 Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile
Arg Lys Ser Gly Val 50 55 60 Pro Ser Arg Phe Ser Gly Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Pro Glu
Asp Leu Ala Thr Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Ser Tyr Pro
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 100 105 110 Lys
<210> SEQ ID NO 6 <211> LENGTH: 116 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 6
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Ala 1 5
10 15 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn
Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Thr Ser Asp Lys Arg Leu
Glu Trp Val 35 40 45 Ala Ser Ile Ser Ser Gly Gly Gly Ser Thr Tyr
Tyr Pro Asp Asn Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Glu
Asp Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg
Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ser Arg Gly Gly Ala
Gly Ile Asp Tyr Trp Gly Gln Gly Thr Thr Leu 100 105 110 Thr Val Ser
Ser 115 <210> SEQ ID NO 7 <211> LENGTH: 116 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 7 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro
Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr
Phe Ser Ser Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Gln Asp Gly Ser
Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg
Gly Ser Ser Asp Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> SEQ ID NO 8 <211> LENGTH: 116
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 8 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ser Ser
Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Asn Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ser Arg Gly Gly Ala Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110 Thr Val Ser Ser 115 <210> SEQ ID NO 9 <211>
LENGTH: 116 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 9 Glu Val Gln Leu Val Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met Ser Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser
Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Asn Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ser Arg Gly Gly Ala Gly Ile Asp Tyr Trp Gly Gln
Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> SEQ ID
NO 10 <211> LENGTH: 116 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 10 Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25
30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 Ala Ser Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp
Asn Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys
Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ala Gly Ile Asp
Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115
<210> SEQ ID NO 11 <211> LENGTH: 116 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 11
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn
Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ala Ser Ile Ser Ser Gly Gly Gly Ser Thr Tyr
Tyr Pro Asp Asn Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ala
Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser
Ser 115 <210> SEQ ID NO 12 <211> LENGTH: 140
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 12 Met Asp Val Phe Met Lys Gly Leu Ser Lys
Ala Lys Glu Gly Val Val 1 5 10 15 Ala Ala Ala Glu Lys Thr Lys Gln
Gly Val Ala Glu Ala Ala Gly Lys 20 25 30 Thr Lys Glu Gly Val Leu
Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 35 40 45 Val His Gly Val
Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 50 55 60 Asn Val
Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 65 70 75 80
Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 85
90 95 Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly
Ile 100 105 110 Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr
Glu Met Pro 115 120 125 Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu
Ala 130 135 140 <210> SEQ ID NO 13 <211> LENGTH: 107
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 13 Arg Thr Val Ala Ala Pro Ser Val Phe Ile
Phe Pro Pro Ser Asp Glu 1 5 10 15 Gln Leu Lys Ser Gly Thr Ala Ser
Val Val Cys Leu Leu Asn Asn Phe 20 25 30 Tyr Pro Arg Glu Ala Lys
Val Gln Trp Lys Val Asp Asn Ala Leu Gln 35 40 45 Ser Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 50 55 60 Thr Tyr
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 65 70 75 80
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 85
90 95 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105
<210> SEQ ID NO 14 <211> LENGTH: 324 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 14
cgaaactgtg gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc
60 tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg
ccaaagtaca 120 gtggaaggtg gataacgccc tccaatcggg taactcccag
gagagtgtca cagagcagga 180 cagcaaggac agcacctaca gcctcagcag
caccctgacg ctgagcaaag cagactacga 240 gaaacacaaa gtctacgcct
gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa 300 gagctcaaca
ggggagagtg ttag 324 <210> SEQ ID NO 15 <211> LENGTH:
330 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 15 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala
Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85
90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu
Val His Asn Val Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210
215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> SEQ ID NO
16 <211> LENGTH: 991 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 16 gcctccacca
agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg
120 tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct
acagtcctca 180 ggactctact ccctcagcag cgtggtgacc gtgccctcca
gcagcttggg cacccagacc 240 acatctgcaa cgtgaatcac aagcccagca
acaccaaggt ggacaagaga gttgagccca 300 aatcttgtga caaaactcac
acatgcccac cgtgcccagc acctgaactc ctggggggac 360 cgtcagtctt
cctcttcccc ccaaaaccca aggacaccct catgatctcc cggacccctg 420
aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt
480 acgtggacgg cgtggaggtg cataatgtca agacaaagcc gcgggaggag
cagtacaaca 540 gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca
ggactggctg aatggcaagg 600 agtacaagtg caaggtctcc aacaaagccc
tcccagcccc catcgagaaa accatctcca 660 aagccaaagg gcagccccga
gaaccacagg tgtacacgct gcccccatcc cgggaggaga 720 tgaccaagaa
ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc agcgacatcg 780
cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct
840 ggactccgac ggctccttct tcctctatag caagctcacc gtggacaaga
gcaggtggca 900 gcaggggaac gtcttctcat gctccgtgat gcatgaggct
ctgcacaacc actacacgca 960 gaagagcctc tccctgtccc cgggtaaatg a 991
<210> SEQ ID NO 17 <211> LENGTH: 339 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 17
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc
60 atcacctgca agtccatcca gaccctgctg tactcctcca accagaagaa
ctacctggcc 120 tggttccagc agaagcccgg caaggccccc aagctgctga
tctactgggc ctccatccgc 180 aagtccggcg tgccctcccg cttctccggc
tccggctccg gcaccgactt caccctgacc 240 atctcctccc tgcagcccga
ggacttcgcc acctactact gccagcagta ctactcctac 300 cccctgacct
tcggcggcgg caccaagctg gagatcaag 339 <210> SEQ ID NO 18
<211> LENGTH: 339 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 18 gacatccaga
tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc 60
atcacctgca agtccatcca gaccctgctg tactcctcca accagaagaa ctacctggcc
120 tggtaccagc agaagcccgg caaggccccc aagctgctga tctactgggc
ctccatccgc 180 aagtccggcg tgccctcccg cttctccggc tccggctccg
gcaccgactt caccctgacc 240 atctcctccc tgcagcccga ggacttcgcc
acctactact gccagcagta ctactcctac 300 cccctgacct tcggcggcgg
caccaagctg gagatcaag 339 <210> SEQ ID NO 19 <211>
LENGTH: 339 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 19 gacatccaga tgacccagtc
cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc 60 atcacctgca
agtccatcca gaccctgctg tactcctcca accagaagaa ctacctggcc 120
tggttccagc agaagcccgg caaggccccc aagctgctga tctactgggc ctccatccgc
180 aagtccggcg tgccctcccg cttctccggc tccggctccg gcaccgactt
caccctgacc 240 atctcctccc tgcagcccga ggacctggcc acctactact
gccagcagta ctactcctac 300 cccctgacct tcggcggcgg caccaagctg
gagatcaag 339 <210> SEQ ID NO 20 <211> LENGTH: 348
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 20 gaggtgcagc tggtggagtc cggcggcggc
ctggtgcagc ccggcggctc cctgcgcctg 60 tcctgcgccg cctccggctt
caccttctcc aactacggca tgtcctgggt gcgccaggcc 120 cccggcaagg
gcctggagtg ggtggcctcc atctcctccg gcggcggctc cacctactac 180
cccgacaacg tgaagggccg cttcaccatc tcccgcgacg acgccaagaa ctccctgtac
240 ctgcagatga actccctgcg cgccgaggac accgccgtgt actactgctc
ccgcggcggc 300 gccggcatcg actactgggg ccagggcacc ctggtgaccg tgtcctcc
348 <210> SEQ ID NO 21 <211> LENGTH: 348 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 21 gaggtgcagc tggtggagtc cggcggcggc ctggtgcagc ccggcggctc
cctgcgcctg 60 tcctgcgccg cctccggctt caccttctcc aactacggca
tgtcctgggt gcgccaggcc 120 cccggcaagg gcctggagtg ggtggcctcc
atctcctccg gcggcggctc cacctactac 180 cccgacaacg tgaagggccg
cttcaccatc tcccgcgaca acgccaagaa ctccctgtac 240 ctgcagatga
actccctgcg cgccgaggac accgccgtgt actactgctc ccgcggcggc 300
gccggcatcg actactgggg ccagggcacc ctggtgaccg tgtcctcc 348
<210> SEQ ID NO 22 <211> LENGTH: 348 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 22
gaggtgcagc tggtggagtc cggcggcggc ctggtgcagc ccggcggctc cctgcgcctg
60 tcctgcgccg cctccggctt caccttctcc aactacggca tgtcctgggt
gcgccaggcc 120 cccggcaagg gcctggagtg ggtggcctcc atctcctccg
gcggcggctc cacctactac 180 cccgacaacg tgaagggccg cttcaccatc
tcccgcgacg acgccaagaa ctccctgtac 240 ctgcagatga actccctgcg
cgccgaggac accgccgtgt actactgcgc ccgcggcggc 300 gccggcatcg
actactgggg ccagggcacc ctggtgaccg tgtcctcc 348 <210> SEQ ID NO
23 <211> LENGTH: 348 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 23 gaggtgcagc
tggtggagtc cggcggcggc ctggtgcagc ccggcggctc cctgcgcctg 60
tcctgcgccg cctccggctt caccttctcc aactacggca tgtcctgggt gcgccaggcc
120 cccggcaagg gcctggagtg ggtggcctcc atctcctccg gcggcggctc
cacctactac 180 cccgacaacg tgaagggccg cttcaccatc tcccgcgaca
acgccaagaa ctccctgtac 240 ctgcagatga actccctgcg cgccgaggac
accgccgtgt actactgcgc ccgcggcggc 300 gccggcatcg actactgggg
ccagggcacc ctggtgaccg tgtcctcc 348 <210> SEQ ID NO 24
<211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 24 Met Asp Met Arg
Val Pro Ala Gln Leu Leu Gly Leu Leu Met Leu Trp 1 5 10 15 Val Ser
Gly Ser Ser Gly 20 <210> SEQ ID NO 25 <211> LENGTH: 66
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 25 atggacatgc gcgtgcccgc ccagctgctg
ggcctgctga tgctgtgggt gtccggctcc 60 tccggc 66 <210> SEQ ID NO
26 <211> LENGTH: 19 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 26 Met Glu Phe
Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 1 5 10 15 Val
Gln Cys <210> SEQ ID NO 27 <211> LENGTH: 57 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 27 atggagttcg gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt
gcagtgc 57 <210> SEQ ID NO 28 <211> LENGTH: 113
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (42)..(42) <223> OTHER INFORMATION: Xaa = Y or F
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (89)..(89) <223> OTHER INFORMATION: Xaa = F or L
<400> SEQUENCE: 28 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys
Ser Ile Gln Thr Leu Leu Tyr Ser 20 25 30 Ser Asn Gln Lys Asn Tyr
Leu Ala Trp Xaa Gln Gln Lys Pro Gly Lys 35 40 45 Ala Pro Lys Leu
Leu Ile Tyr Trp Ala Ser Ile Arg Lys Ser Gly Val 50 55 60 Pro Ser
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80
Ile Ser Ser Leu Gln Pro Glu Asp Xaa Ala Thr Tyr Tyr Cys Gln Gln 85
90 95 Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
Ile 100 105 110 Lys <210> SEQ ID NO 29 <211> LENGTH:
116 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (74)..(74) <223> OTHER INFORMATION: Xaa = N or D
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (97)..(97) <223> OTHER INFORMATION: Xaa = A or S
<400> SEQUENCE: 29 Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ser
Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Asn Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Xaa Ala Lys Asn Ser Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Xaa Arg Gly Gly Ala Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu
Val 100 105 110 Thr Val Ser Ser 115 <210> SEQ ID NO 30
<211> LENGTH: 106 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 30 Thr Val Ala Ala
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 1 5 10 15 Leu Lys
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 20 25 30
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 35
40 45 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
Thr 50 55 60 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
Tyr Glu Lys 65 70 75 80 His Lys Val Tyr Ala Cys Glu Val Thr His Gln
Gly Leu Ser Ser Pro 85 90 95 Val Thr Lys Ser Phe Asn Arg Gly Glu
Cys 100 105 <210> SEQ ID NO 31 <211> LENGTH: 321
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 31 aactgtggct gcaccatctg tcttcatctt
cccgccatct gatgagcagt tgaaatctgg 60 aactgcctct gttgtgtgcc
tgctgaataa cttctatccc agagaggcca aagtacagtg 120 gaaggtggat
aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag 180
caaggacagc acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa
240 acacaaagtc tacgcctgcg aagtcaccca tcagggcctg agctcgcccg
tcacaaagag 300 ctcaacaggg gagagtgtta g 321 <210> SEQ ID NO 32
<211> LENGTH: 220 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 32 Asp Ile Gln Met
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg
Val Thr Ile Thr Cys Lys Ser Ile Gln Thr Leu Leu Tyr Ser 20 25 30
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 35
40 45 Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Lys Ser Gly
Val 50 55 60 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Pro Glu Asp Leu Ala Thr
Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly
Gly Gly Thr Lys Leu Glu Ile 100 105 110 Lys Arg Thr Val Ala Ala Pro
Ser Val Phe Ile Phe Pro Pro Ser Asp 115 120 125 Glu Gln Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 130 135 140 Phe Tyr Pro
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 145 150 155 160
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 165
170 175 Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
Tyr 180 185 190 Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln
Gly Leu Ser 195 200 205 Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
Cys 210 215 220 <210> SEQ ID NO 33 <211> LENGTH: 219
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 33 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys
Ser Ile Gln Thr Leu Leu Tyr Ser 20 25 30 Ser Asn Gln Lys Asn Tyr
Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 35 40 45 Ala Pro Lys Leu
Leu Ile Tyr Trp Ala Ser Ile Arg Lys Ser Gly Val 50 55 60 Pro Ser
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80
Ile Ser Ser Leu Gln Pro Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln 85
90 95 Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
Ile 100 105 110 Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
Ser Asp Glu 115 120 125 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys
Leu Leu Asn Asn Phe 130 135 140 Tyr Pro Arg Glu Ala Lys Val Gln Trp
Lys Val Asp Asn Ala Leu Gln 145 150 155 160 Ser Gly Asn Ser Gln Glu
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 165 170 175 Thr Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 180 185 190 Lys His
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 195 200 205
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> SEQ
ID NO 34 <211> LENGTH: 446 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 34 Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25
30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 Ala Ser Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp
Asn Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys
Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ala Gly Ile Asp
Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser Ala Ser
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 115 120 125 Pro Ser Ser Lys
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 130 135 140 Val Lys
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 145 150 155
160 Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
165 170 175 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
Ser Leu 180 185 190 Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
Pro Ser Asn Thr 195 200 205 Lys Val Asp Lys Arg Val Glu Pro Lys Ser
Cys Asp Lys Thr His Thr 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu
Leu Leu Gly Gly Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 260 265 270 Lys
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Val Lys Thr 275 280
285 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
290 295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
Lys Cys 305 310 315 320 Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro 340 345 350 Ser Arg Glu Glu Met Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val 355 360 365 Lys Gly Phe Tyr Pro
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375 380 Gln Pro Glu
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 385 390 395 400
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 405
410 415 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His 420 425 430 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
Lys 435 440 445 <210> SEQ ID NO 35 <211> LENGTH: 330
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 35 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala
Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85
90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210
215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> SEQ ID NO
36 <211> LENGTH: 446 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 36 Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25
30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 Ala Ser Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp
Asn Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys
Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ala Gly Ile Asp
Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser Ala Ser
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 115 120 125 Pro Ser Ser Lys
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 130 135 140 Val Lys
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 145 150 155
160 Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
165 170 175 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
Ser Leu 180 185 190 Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
Pro Ser Asn Thr 195 200 205 Lys Val Asp Lys Arg Val Glu Pro Lys Ser
Cys Asp Lys Thr His Thr 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu
Leu Leu Gly Gly Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 260 265 270 Lys
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Val Lys Thr 275 280
285 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
290 295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
Lys Cys 305 310 315 320 Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro 340 345 350 Ser Arg Glu Glu Met Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val 355 360 365 Lys Gly Phe Tyr Pro
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375 380 Gln Pro Glu
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 385 390 395 400
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 405
410 415 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His 420 425 430 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
Lys 435 440 445 <210> SEQ ID NO 37 <211> LENGTH: 446
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 37 Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ser
Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Asn Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Gly Gly Ala Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu
Val 100 105 110 Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
Pro Leu Ala 115 120 125 Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
Ala Leu Gly Cys Leu 130 135 140 Val Lys Asp Tyr Phe Pro Glu Pro Val
Thr Val Ser Trp Asn Ser Gly 145 150 155 160 Ala Leu Thr Ser Gly Val
His Thr Phe Pro Ala Val Leu Gln Ser Ser 165 170 175 Gly Leu Tyr Ser
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 180 185 190 Gly Thr
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 195 200 205
Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 210
215 220 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
Phe 225 230 235 240 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
Ser Arg Thr Pro 245 250 255 Glu Val Thr Cys Val Val Val Asp Val Ser
His Glu Asp Pro Glu Val 260 265 270 Lys Phe Asn Trp Tyr Val Asp Gly
Val Glu Val His Asn Ala Lys Thr 275 280 285 Lys Pro Arg Glu Glu Gln
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 290 295 300 Leu Thr Val Leu
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 305 310 315 320 Lys
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 325 330
335 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
340 345 350 Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
Leu Val 355 360 365 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
Glu Ser Asn Gly 370 375 380 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
Pro Val Leu Asp Ser Asp 385 390 395 400 Gly Ser Phe Phe Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp 405 410 415 Gln Gln Gly Asn Val
Phe Ser Cys Ser Val Met His Glu Ala Leu His 420 425 430 Asn His Tyr
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210>
SEQ ID NO 38 <211> LENGTH: 345 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 38
caggtccagc tgcagcagtc tggggctgaa ctggcaaaac ctgggacctc agtgcagatg
60 tcctgcaagg cttctggcta cacctttact aattactgga tgaactggat
aaaagcgagg 120 cctggacagg gtctggaatg gattggggct actaatccta
acaatggtta tactgactac 180 aatcagaggt tcaaggacaa ggccatatta
actgcagaca aatcctccaa tacagcctac 240 atgcacctga gcagcctgac
atctgaagac tctgcagtct atttctgtgc aagtgggggg 300 cacttggctt
actggggcca ggggactgtg gtcactgtct ctgca 345 <210> SEQ ID NO 39
<211> LENGTH: 115 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 39 Gln Val Gln Leu
Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Thr 1 5 10 15 Ser Val
Gln Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30
Trp Met Asn Trp Ile Lys Ala Arg Pro Gly Gln Gly Leu Glu Trp Ile 35
40 45 Gly Ala Thr Asn Pro Asn Asn Gly Tyr Thr Asp Tyr Asn Gln Arg
Phe 50 55 60 Lys Asp Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Asn
Thr Ala Tyr 65 70 75 80 Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser
Ala Val Tyr Phe Cys 85 90 95 Ala Ser Gly Gly His Leu Ala Tyr Trp
Gly Gln Gly Thr Val Val Thr 100 105 110 Val Ser Ala 115 <210>
SEQ ID NO 40 <211> LENGTH: 57 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 40
atggaaaggc actggatctt tctcttcctg ttatcagtaa ctggaggtgt ccactcc 57
<210> SEQ ID NO 41 <211> LENGTH: 19 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 41
Met Glu Arg His Trp Ile Phe Leu Phe Leu Leu Ser Val Thr Gly Gly 1 5
10 15 Val His Ser <210> SEQ ID NO 42 <211> LENGTH: 336
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 42 gatgttgtga tgacccaaat tccactctac
ctgtctgtca gtcctggaga tcaagcctcc 60 atctcttgca gatctagtca
gagccttttc catagtaaag gaaacaccta tttacattgg 120 tatctgcaga
agccaggcca gtctccaaag ctcctgatca acagggtttc caaccgattt 180
tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc
240 agcggagtgg aggctgaaga tctgggagtt tatttctgtt ctcaaagtgc
acatgttccg 300 tggacgttcg gtggaggcac caagctggaa atcaga 336
<210> SEQ ID NO 43 <211> LENGTH: 112 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 43
Asp Val Val Met Thr Gln Ile Pro Leu Tyr Leu Ser Val Ser Pro Gly 1 5
10 15 Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Phe His
Ser 20 25 30 Lys Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro
Gly Gln Ser 35 40 45 Pro Lys Leu Leu Ile Asn Arg Val Ser Asn Arg
Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Gly Val Glu Ala Glu Asp
Leu Gly Val Tyr Phe Cys Ser Gln Ser 85 90 95 Ala His Val Pro Trp
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 100 105 110 <210>
SEQ ID NO 44 <211> LENGTH: 60 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 44
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat
60 <210> SEQ ID NO 45 <211> LENGTH: 20 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 45 Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp
Ile Pro Ala 1 5 10 15 Ser Ser Ser Asp 20 <210> SEQ ID NO 46
<211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 46 Val Asp Pro Asp
Asn Glu Ala Tyr Glu Gly Gly Cys 1 5 10 <210> SEQ ID NO 47
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 47 Asn Tyr Trp Met
Asn 1 5 <210> SEQ ID NO 48 <211> LENGTH: 17 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 48 Ala Thr Asn Pro Asn Asn Gly Tyr Thr Asp Tyr Asn Gln
Arg Phe Lys 1 5 10 15 Asp <210> SEQ ID NO 49 <211>
LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 49 Gly Gly His Leu Ala Tyr 1 5
<210> SEQ ID NO 50 <211> LENGTH: 16 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 50
Arg Ser Ser Gln Ser Leu Phe His Ser Lys Gly Asn Thr Tyr Leu His 1 5
10 15 <210> SEQ ID NO 51 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 51 Arg Val Ser Asn Arg Phe Ser 1 5 <210> SEQ ID NO
52 <211> LENGTH: 9 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 52 Ser Gln Ser
Ala His Val Pro Trp Thr 1 5 <210> SEQ ID NO 53 <211>
LENGTH: 402 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 53 atggaaaggc actggatctt
tctcttcctg ttatcagtaa ctggaggtgt ccactcccag 60 gtccagctgc
agcagtctgg ggctgaactg gcaaaacctg ggacctcagt gcagatgtcc 120
tgcaaggctt ctggctacac ctttactaat tactggatga actggataaa agcgaggcct
180 ggacagggtc tggaatggat tggggctact aatcctaaca atggttatac
tgactacaat 240 cagaggttca aggacaaggc catattaact gcagacaaat
cctccaatac agcctacatg 300 cacctgagca gcctgacatc tgaagactct
gcagtctatt tctgtgcaag tggggggcac 360 ttggcttact ggggccaggg
gactgtggtc actgtctctg ca 402 <210> SEQ ID NO 54 <211>
LENGTH: 134 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 54 Met Glu Arg His Trp Ile Phe
Leu Phe Leu Leu Ser Val Thr Gly Gly 1 5 10 15 Val His Ser Gln Val
Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys 20 25 30 Pro Gly Thr
Ser Val Gln Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45 Thr
Asn Tyr Trp Met Asn Trp Ile Lys Ala Arg Pro Gly Gln Gly Leu 50 55
60 Glu Trp Ile Gly Ala Thr Asn Pro Asn Asn Gly Tyr Thr Asp Tyr Asn
65 70 75 80 Gln Arg Phe Lys Asp Lys Ala Ile Leu Thr Ala Asp Lys Ser
Ser Asn 85 90 95 Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu
Asp Ser Ala Val 100 105 110 Tyr Phe Cys Ala Ser Gly Gly His Leu Ala
Tyr Trp Gly Gln Gly Thr 115 120 125 Val Val Thr Val Ser Ala 130
<210> SEQ ID NO 55 <211> LENGTH: 393 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 55
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat
60 gttgtgatga cccaaattcc actctacctg tctgtcagtc ctggagatca
agcctccatc 120 tcttgcagat ctagtcagag ccttttccat agtaaaggaa
acacctattt acattggtat 180 ctgcagaagc caggccagtc tccaaagctc
ctgatcaaca gggtttccaa ccgattttct 240 ggggtcccag acaggttcag
tggcagtgga tcagggacag atttcacact caagatcagc 300 ggagtggagg
ctgaagatct gggagtttat ttctgttctc aaagtgcaca tgttccgtgg 360
acgttcggtg gaggcaccaa gctggaaatc aga 393 <210> SEQ ID NO 56
<211> LENGTH: 131 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 56 Met Lys Leu Pro
Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 1 5 10 15 Ser Ser
Ser Asp Val Val Met Thr Gln Ile Pro Leu Tyr Leu Ser Val 20 25 30
Ser Pro Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35
40 45 Phe His Ser Lys Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys
Pro 50 55 60 Gly Gln Ser Pro Lys Leu Leu Ile Asn Arg Val Ser Asn
Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser
Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Gly Val Glu Ala Glu
Asp Leu Gly Val Tyr Phe Cys 100 105 110 Ser Gln Ser Ala His Val Pro
Trp Thr Phe Gly Gly Gly Thr Lys Leu 115 120 125 Glu Ile Arg 130
<210> SEQ ID NO 57 <211> LENGTH: 118 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 57
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5
10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn
Tyr 20 25 30 Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Thr
Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp
Glu Ser Thr Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg
Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Asn
Leu Asn Trp Leu Asp Pro Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr
Val Ser Ser 115 <210> SEQ ID NO 58 <211> LENGTH: 115
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 58 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Leu Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Met Asn Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ala Thr Asn
Pro Asn Asn Gly Tyr Thr Asp Tyr Asn Gln Arg Phe 50 55 60 Lys Asp
Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Gly Gly His Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val
Thr 100 105 110 Val Ser Ser 115 <210> SEQ ID NO 59
<211> LENGTH: 115 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 59 Gln Val Gln Leu
Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 1 5 10 15 Ser Val
Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35
40 45 Gly Ala Thr Asn Pro Asn Asn Gly Tyr Thr Asp Tyr Asn Gln Arg
Phe 50 55 60 Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn
Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly His Leu Ala Tyr Trp
Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210>
SEQ ID NO 60 <211> LENGTH: 115 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 60
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 1 5
10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn
Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu Trp Ile 35 40 45 Gly Ala Thr Asn Pro Asn Asn Gly Tyr Thr Asp
Tyr Asn Gln Arg Phe 50 55 60 Lys Asp Arg Ala Thr Leu Thr Ala Asp
Lys Ser Thr Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg
Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Gly Gly His
Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser
115 <210> SEQ ID NO 61 <211> LENGTH: 115 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 61 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys
Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
Thr Phe Thr Asn Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ala Thr Asn Pro Asn Asn
Gly Tyr Thr Asp Tyr Asn Gln Arg Phe 50 55 60 Lys Asp Arg Ala Thr
Leu Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Ser Gly Gly His Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 100 105
110 Val Ser Ser 115 <210> SEQ ID NO 62 <211> LENGTH:
115 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 62 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Leu Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Met Asn Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ala Thr Asn
Pro Asn Asn Gly Tyr Thr Asp Tyr Asn Gln Arg Phe 50 55 60 Lys Asp
Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Ser Gly Gly His Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val
Thr 100 105 110 Val Ser Ser 115 <210> SEQ ID NO 63
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 63 atggagttcg
gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt gcagtgccag 60
gtgcagctgg tgcagtccgg cgccgagctg aagaagcccg gctcctccgt gaaggtgtcc
120 tgcaaggcct ccggctacac cttcaccaac tactggatga actgggtgcg
ccaggccccc 180 ggccagggcc tggagtggat cggcgccacc aaccccaaca
acggctacac cgactacaac 240 cagcgcttca aggaccgcgc caccctgacc
gccgacaagt ccaccaacac cgcctacatg 300 gagctgtcct ccctgcgctc
cgaggacacc gccgtgtact actgcgcccg cggcggccac 360 ctggcctact
ggggccaggg caccctggtg accgtgtcct cc 402 <210> SEQ ID NO 64
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 64 atggagttcg
gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt gcagtgccag 60
gtgcagctgg tgcagtccgg cgccgagctg aagaagcccg gctcctccgt gaaggtgtcc
120 tgcaaggcct ccggctacac cttcaccaac tactggatga actgggtgcg
ccaggccccc 180 ggccagggcc tggagtggat cggcgccacc aaccccaaca
acggctacac cgactacaac 240 cagcgcttca aggaccgcgt gaccatcacc
gccgacaagt ccaccaacac cgcctacatg 300 gagctgtcct ccctgcgctc
cgaggacacc gccgtgtact actgcgcccg cggcggccac 360 ctggcctact
ggggccaggg caccctggtg accgtgtcct cc 402 <210> SEQ ID NO 65
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 65 atggagttcg
gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt gcagtgccag 60
gtgcagctgg tgcagtccgg cgccgagctg aagaagcccg gctcctccgt gaaggtgtcc
120 tgcaaggcct ccggctacac cttcaccaac tactggatga actgggtgcg
ccaggccccc 180 ggccagggcc tggagtggat cggcgccacc aaccccaaca
acggctacac cgactacaac 240 cagcgcttca aggaccgcgc caccctgacc
gccgacaagt ccaccaacac cgcctacatg 300 gagctgtcct ccctgcgctc
cgaggacacc gccgtgtact tctgcgcctc cggcggccac 360 ctggcctact
ggggccaggg caccctggtg accgtgtcct cc 402 <210> SEQ ID NO 66
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 66 atggagttcg
gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt gcagtgccag 60
gtgcagctgg tgcagtccgg cgccgagctg aagaagcccg gctcctccgt gaaggtgtcc
120 tgcaaggcct ccggctacac cttcaccaac tactggatga actgggtgcg
ccaggccccc 180 ggccagggcc tggagtggat cggcgccacc aaccccaaca
acggctacac cgactacaac 240 cagcgcttca aggaccgcgc caccctgacc
gccgacaagt ccaccaacac cgcctacatg 300 gagctgtcct ccctgcgctc
cgaggacacc gccgtgtact actgcgcctc cggcggccac 360 ctggcctact
ggggccaggg caccctggtg accgtgtcct cc 402 <210> SEQ ID NO 67
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 67 atggagttcg
gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt gcagtgccag 60
gtgcagctgg tgcagtccgg cgccgagctg aagaagcccg gctcctccgt gaaggtgtcc
120 tgcaaggcct ccggctacac cttcaccaac tactggatga actgggtgcg
ccaggccccc 180 ggccagggcc tggagtggat cggcgccacc aaccccaaca
acggctacac cgactacaac 240 cagcgcttca aggaccgcgt gaccatcacc
gccgacaagt ccaccaacac cgcctacatg 300 gagctgtcct ccctgcgctc
cgaggacacc gccgtgtact actgcgccag cggcggccac 360 ctggcctact
ggggccaggg caccctggtg accgtgtcct cc 402 <210> SEQ ID NO 68
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 68 Asp Ile Val Met
Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro
Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35
40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val
Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Pro Thr Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> SEQ ID NO 69
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 69 Asp Val Val Met
Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Pro
Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Phe His Ser 20 25 30
Lys Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35
40 45 Pro Lys Leu Leu Ile Asn Arg Val Ser Asn Arg Phe Ser Gly Val
Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
Phe Cys Ser Gln Ser 85 90 95 Ala His Val Pro Trp Thr Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> SEQ ID NO 70
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 70 Asp Ile Val Met
Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Pro
Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Phe His Ser 20 25 30
Lys Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35
40 45 Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val
Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
Phe Cys Ser Gln Ser 85 90 95 Ala His Val Pro Trp Thr Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> SEQ ID NO 71
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 71 Asp Val Val Met
Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Pro
Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Phe His Ser 20 25 30
Lys Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35
40 45 Pro Gln Leu Leu Ile Asn Arg Val Ser Asn Arg Phe Ser Gly Val
Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
Phe Cys Ser Gln Ser 85 90 95 Ala His Val Pro Trp Thr Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> SEQ ID NO 72
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 72 Asp Ile Val Met
Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Pro
Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Phe His Ser 20 25 30
Lys Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35
40 45 Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val
Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
Phe Cys Ser Gln Ser 85 90 95 Ala His Val Pro Trp Thr Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> SEQ ID NO 73
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 73 atggacatgc
gcgtgcccgc ccagctgctg ggcctgctga tgctgtgggt gtccggctcc 60
tccggcgacg tggtgatgac ccagtccccc ctgtccctgt ccgtgtcccc cggcgagccc
120 gcctccatct cctgccgctc ctcccagtcc ctgttccact ccaagggcaa
cacctacctg 180 cactggtacc tgcagaagcc cggccagtcc cccaagctgc
tgatcaaccg cgtgtccaac 240 cgcttctccg gcgtgcccga ccgcttctcc
ggctccggct ccggcaccga cttcaccctg 300 aagatctccc gcgtggaggc
cgaggacgtg ggcgtgtact tctgctccca gtccgcccac 360 gtgccctgga
ccttcggcgg cggcaccaag gtggagatca ag 402 <210> SEQ ID NO 74
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 74 atggacatgc
gcgtgcccgc ccagctgctg ggcctgctga tgctgtgggt gtccggctcc 60
tccggcgaca tcgtgatgac ccagtccccc ctgtccctgt ccgtgtcccc cggcgagccc
120 gcctccatct cctgccgctc ctcccagtcc ctgttccact ccaagggcaa
cacctacctg 180 cactggtacc tgcagaagcc cggccagtcc cccaagctgc
tgatctaccg cgtgtccaac 240 cgcttctccg gcgtgcccga ccgcttctcc
ggctccggct ccggcaccga cttcaccctg 300 aagatctccc gcgtggaggc
cgaggacgtg ggcgtgtact actgctccca gtccgcccac 360 gtgccctgga
ccttcggcgg cggcaccaag gtggagatca ag 402 <210> SEQ ID NO 75
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 75 atggacatgc
gcgtgcccgc ccagctgctg ggcctgctga tgctgtgggt gtccggctcc 60
tccggcgacg tggtgatgac ccagtccccc ctgtccctgt ccgtgtcccc cggcgagccc
120 gcctccatct cctgccgctc ctcccagtcc ctgttccact ccaagggcaa
cacctacctg 180 cactggtacc tgcagaagcc cggccagtcc ccccagctgc
tgatcaaccg cgtgtccaac 240 cgcttctccg gcgtgcccga ccgcttctcc
ggctccggct ccggcaccga cttcaccctg 300 aagatctccc gcgtggaggc
cgaggacgtg ggcgtgtact tctgctccca gtccgcccac 360 gtgccctgga
ccttcggcgg cggcaccaag gtggagatca ag 402 <210> SEQ ID NO 76
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 76 atggacatgc
gcgtgcccgc ccagctgctg ggcctgctga tgctgtgggt gtccggctcc 60
tccggcgaca tcgtgatgac ccagtccccc ctgtccctgt ccgtgtcccc cggcgagccc
120 gcctccatct cctgccgctc ctcccagtcc ctgttccact ccaagggcaa
cacctacctg 180 cactggtacc tgcagaagcc cggccagtcc ccccagctgc
tgatctaccg cgtgtccaac 240 cgcttctccg gcgtgcccga ccgcttctcc
ggctccggct ccggcaccga cttcaccctg 300 aagatctccc gcgtggaggc
cgaggacgtg ggcgtgtact actgctccca gtccgcccac 360 gtgccctgga
ccttcggcgg cggcaccaag gtggagatca ag 402 <210> SEQ ID NO 77
<211> LENGTH: 321 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 77 actgtggctg
caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 60
actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg
120 aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga
gcaggacagc 180 aaggacagca cctacagcct cagcagcacc ctgacgctga
gcaaagcaga ctacgagaaa 240 cacaaagtct acgcctgcga agtcacccat
cagggcctga gctcgcccgt cacaaagagc 300 ttcaacaggg gagagtgtta g 321
<210> SEQ ID NO 78 <211> LENGTH: 35 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 78
Glu Gln Val Thr Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala 1 5
10 15 Val Ala Gln Lys Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala
Thr 20 25 30 Gly Phe Val 35 <210> SEQ ID NO 79 <211>
LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 79 Lys Glu Gln Val Thr Asn Val
Gly Gly Ala Val Val Thr Gly Val Thr 1 5 10 15 Ala Val Ala Gln Lys
Thr Val Glu Gly Ala Gly Ser 20 25 <210> SEQ ID NO 80
<211> LENGTH: 405 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 80 atgggatgga
gctgggtctt tatcttcctc ctgtcaggaa ctgcaggtgt ccattgccag 60
gtccagctgc agcagtctgg acctgagctg gtgaagcctg ggacttcagt gaagatatcc
120 tgcaaggctt ctggctacag cttcacaagc tactatatac actgggtgaa
gcagagtcct 180 ggacagggac ttgagtggat tggatggatt tatcctggaa
gtggtaatac taagtacagt 240 gagaagttca agggcaaggc cacactgact
gcagacacat cctccagcac agcctacatg 300 cagctcagca gcctgacatc
tgaggactct gcagtctatt tctgtgcaag agatggttgc 360 tacgggtttg
cttactgggg ccaagggact ctggtcactg tctct 405 <210> SEQ ID NO 81
<211> LENGTH: 135 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 81 Met Gly Trp Ser
Trp Val Phe Ile Phe Leu Leu Ser Gly Thr Ala Gly 1 5 10 15 Val His
Cys Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 20 25 30
Pro Gly Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 35
40 45 Thr Ser Tyr Tyr Ile His Trp Val Lys Gln Ser Pro Gly Gln Gly
Leu 50 55 60 Glu Trp Ile Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr
Lys Tyr Ser 65 70 75 80 Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala
Asp Thr Ser Ser Ser 85 90 95 Thr Ala Tyr Met Gln Leu Ser Ser Leu
Thr Ser Glu Asp Ser Ala Val 100 105 110 Tyr Phe Cys Ala Arg Asp Gly
Cys Tyr Gly Phe Ala Tyr Trp Gly Gln 115 120 125 Gly Thr Leu Val Thr
Val Ser 130 135 <210> SEQ ID NO 82 <211> LENGTH: 393
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 82 atggagacag acacactcct gttatgggtg
ctgctgctct gggttccagg ctccactggt 60 gacattgtgc tgacccaatc
tccagcttct ttggctgtgt ctctagggca gagggccacc 120 atctcctgca
aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac 180
caacagaaac caggacagcc acccaaattc ctcatctgtg ctgcatccaa tctagaatct
240 gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct
caacatccat 300 cctgtggagg aggaggatgc tgcaacctat tactgtcagc
aaagtaatga ggatccattc 360 acgttcggct cggggacaaa gttggaaata aaa 393
<210> SEQ ID NO 83 <211> LENGTH: 131 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 83
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5
10 15 Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu
Ala 20 25 30 Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala
Ser Gln Ser 35 40 45 Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn Trp
Tyr Gln Gln Lys Pro 50 55 60 Gly Gln Pro Pro Lys Phe Leu Ile Cys
Ala Ala Ser Asn Leu Glu Ser 65 70 75 80 Gly Ile Pro Ala Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Asn Ile His Pro
Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 100 105 110 Gln Gln Ser
Asn Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 115 120 125 Glu
Ile Lys 130 <210> SEQ ID NO 84 <211> LENGTH: 345
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 84 gtccagctgc agcagtctgg acctgagctg
gtgaagcctg ggacttcagt gaagatatcc 60 tgcaaggctt ctggctacag
cttcacaagc tactatatac actgggtgaa gcagagtcct 120 ggacagggac
ttgagtggat tggatggatt tatcctggaa gtggtaatac taagtacagt 180
gagaagttca agggcaaggc cacactgact gcagacacat cctccagcac agcctacatg
240 cagctcagca gcctgacatc tgaggactct gcagtctatt tctgtgcaag
agatggttgc 300 tacgggtttg cttactgggg ccaagggact ctggtcactg tctct
345 <210> SEQ ID NO 85 <211> LENGTH: 115 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 85 Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro
Gly Thr Ser 1 5 10 15 Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser
Phe Thr Ser Tyr Tyr 20 25 30 Ile His Trp Val Lys Gln Ser Pro Gly
Gln Gly Leu Glu Trp Ile Gly 35 40 45 Trp Ile Tyr Pro Gly Ser Gly
Asn Thr Lys Tyr Ser Glu Lys Phe Lys 50 55 60 Gly Lys Ala Thr Leu
Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr Met 65 70 75 80 Gln Leu Ser
Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 85 90 95 Arg
Asp Gly Cys Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 100 105
110 Thr Val Ser 115 <210> SEQ ID NO 86 <211> LENGTH:
333 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 86 gacattgtgc tgacccaatc tccagcttct
ttggctgtgt ctctagggca gagggccacc 60 atctcctgca aggccagcca
aagtgttgat tatgatggtg atagttatat gaactggtac 120 caacagaaac
caggacagcc acccaaattc ctcatctgtg ctgcatccaa tctagaatct 180
gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat
240 cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga
ggatccattc 300 acgttcggct cggggacaaa gttggaaata aaa 333 <210>
SEQ ID NO 87 <211> LENGTH: 111 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 87
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5
10 15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr
Asp 20 25 30 Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly
Gln Pro Pro 35 40 45 Lys Phe Leu Ile Cys Ala Ala Ser Asn Leu Glu
Ser Gly Ile Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu Glu Glu Asp Ala
Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 85 90 95 Glu Asp Pro Phe Thr
Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> SEQ
ID NO 88 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 88 Ser Tyr Tyr
Ile His 1 5 <210> SEQ ID NO 89 <211> LENGTH: 17
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 89 Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys
Tyr Ser Glu Lys Phe Lys 1 5 10 15 Gly <210> SEQ ID NO 90
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 90 Asp Gly Cys Tyr
Gly Phe Ala Tyr 1 5 <210> SEQ ID NO 91 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 91 Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly
Asp Ser Tyr Met Asn 1 5 10 15 <210> SEQ ID NO 92 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 92 Ala Ala Ser Asn Leu Glu Ser 1
5 <210> SEQ ID NO 93 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 93
Gln Gln Ser Asn Glu Asp Pro Phe Thr 1 5 <210> SEQ ID NO 94
<211> LENGTH: 351 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 94 caggtgcagc
tggtgcagtc cggcgccgag ctgaagaagc ccggcgcctc cgtgaaggtg 60
tcctgcaagg cctccggcta ctccttcacc tcctactaca tccactgggt gaagcaggcc
120 cccggccagg gcctggagtg gatcggctgg atctaccccg gctccggcaa
caccaagtac 180 tccgagaagt tcaagggccg cgccaccctg accgccgaca
cctccacctc caccgcctac 240 atggagctgc gctccctgcg ctccgacgac
accgccgtgt acttctgcgc ccgcgacggc 300 tgctacggct tcgcctactg
gggccagggc accctggtga ccgtgtcctc a 351 <210> SEQ ID NO 95
<211> LENGTH: 117 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 95 Gln Val Gln Leu
Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val
Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30
Tyr Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35
40 45 Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu Lys
Phe 50 55 60 Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Thr Ser
Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr
Ala Val Tyr Phe Cys 85 90 95 Ala Arg Asp Gly Cys Tyr Gly Phe Ala
Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115
<210> SEQ ID NO 96 <211> LENGTH: 351 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 96
caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgcctc cgtgaaggtg
60 tcctgcaagg cctccggcta ctccttcacc tcctactaca tccactgggt
gcgccaggcc 120 cccggccagg gcctggagtg gatcggctgg atctaccccg
gctccggcaa caccaagtac 180 tccgagaagt tcaagggccg cgccaccctg
accgccgaca cctccacctc caccgcctac 240 atggagctgc gctccctgcg
ctccgacgac accgccgtgt acttctgcgc ccgcgacggc 300 tgctacggct
tcgcctactg gggccagggc accctggtga ccgtgtcctc a 351 <210> SEQ
ID NO 97 <211> LENGTH: 117 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 97 Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25
30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45 Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu
Lys Phe 50 55 60 Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Thr
Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Asp Gly Cys Tyr Gly Phe
Ala Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115
<210> SEQ ID NO 98 <211> LENGTH: 351 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 98
caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgcctc cgtgaaggtg
60 tcctgcaagg cctccggcta caccttcacc tcctactaca tccactgggt
gcgccaggcc 120 cccggccagg gcctggagtg gatgggctgg atctaccccg
gctccggcaa caccaagtac 180 tccgagaagt tcaagggccg cgccaccatg
accgccgaca cctccacctc caccgcctac 240 atggagctgc gctccctgcg
ctccgacgac accgccgtgt actactgcgc ccgcgacggc 300 tgctacggct
tcgcctactg gggccagggc accctggtga ccgtgtcctc a 351 <210> SEQ
ID NO 99 <211> LENGTH: 117 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 99 Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25
30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45 Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu
Lys Phe 50 55 60 Lys Gly Arg Ala Thr Met Thr Ala Asp Thr Ser Thr
Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Cys Tyr Gly Phe
Ala Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115
<210> SEQ ID NO 100 <211> LENGTH: 351 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
100 caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgcctc
cgtgaaggtg 60 tcctgcaagg cctccggcta ctccttcacc tcctactaca
tccactgggt gcgccaggcc 120 cccggccagg gcctggagtg gatcggctgg
atctaccccg gctccggcaa caccaagtac 180 tccgagaagt tcaagggccg
cgccaccctg accgccgaca cctccacctc caccgcctac 240 atggagctgc
gctccctgcg ctccgacgac accgccgtgt acttctgcgc ccgcgacggc 300
tcctacggct tcgcctactg gggccagggc accctggtga ccgtgtcctc a 351
<210> SEQ ID NO 101 <211> LENGTH: 117 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
101 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr
Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Ile 35 40 45 Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr
Lys Tyr Ser Glu Lys Phe 50 55 60 Lys Gly Arg Ala Thr Leu Thr Ala
Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu
Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Asp Gly
Ser Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr
Val Ser Ser 115 <210> SEQ ID NO 102 <211> LENGTH: 351
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 102 caggtgcagc tggtgcagtc cggcgccgag
gtgaagaagc ccggcgcctc cgtgaaggtg 60 tcctgcaagg cctccggcta
caccttcacc tcctactaca tccactgggt gcgccaggcc 120 cccggccagg
gcctggagtg gatgggctgg atctaccccg gctccggcaa caccaagtac 180
tccgagaagt tcaagggccg cgccaccatg accgccgaca cctccacctc caccgcctac
240 atggagctgc gctccctgcg ctccgacgac accgccgtgt actactgcgc
ccgcgacggc 300 tcctacggct tcgcctactg gggccagggc accctggtga
ccgtgtcctc a 351 <210> SEQ ID NO 103 <211> LENGTH: 117
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 103 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr
Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu Lys Phe 50 55 60 Lys Gly
Arg Ala Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr
Leu 100 105 110 Val Thr Val Ser Ser 115 <210> SEQ ID NO 104
<211> LENGTH: 57 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 104 atggagttcg
gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt gcagtgc 57 <210>
SEQ ID NO 105 <211> LENGTH: 19 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
105 Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly
1 5 10 15 Val Gln Cys <210> SEQ ID NO 106 <211> LENGTH:
57 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 106 atggactgga cctggagcat ccttttcttg
gtggcagcag caacaggtgc ccactcc 57 <210> SEQ ID NO 107
<211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 107 Met Asp Trp Thr
Trp Ser Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 1 5 10 15 Ala His
Ser <210> SEQ ID NO 108 <211> LENGTH: 333 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 108 gacatccagc tgacccagtc cccctcctcc ctgtccgcct
ccgtgggcga ccgcgtgacc 60 atcacctgca aggcctccca gtccgtggac
tacgacggcg actcctacat gaactggtac 120 cagcagaagc ccggcaaggc
ccccaagttc ctgatctgcg ccgcctccaa cctggagtcc 180 ggcgtgccct
cccgcttctc cggctccggc tccggcaccg acttcaccct gaccatctcc 240
tccctgcagc ccgaggacgc cgccacctac tactgccagc agtccaacga ggaccccttc
300 accttcggcc agggcaccaa gctggagatc aag 333 <210> SEQ ID NO
109 <211> LENGTH: 111 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 109 Asp Ile
Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20
25 30 Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
Pro 35 40 45 Lys Phe Leu Ile Cys Ala Ala Ser Asn Leu Glu Ser Gly
Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp Ala Ala Thr
Tyr Tyr Cys Gln Gln Ser Asn 85 90 95 Glu Asp Pro Phe Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> SEQ ID NO
110 <211> LENGTH: 333 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 110 gacatccagc
tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc 60
atcacctgca aggcctccca gtccgtggac tacgacggcg actcctacat gaactggtac
120 cagcagaagc ccggcaaggc ccccaagttc ctgatctacg ccgcctccaa
cctggagtcc 180 ggcgtgccct cccgcttctc cggctccggc tccggcaccg
acttcaccct gaccatctcc 240 tccctgcagc ccgaggacgc cgccacctac
tactgccagc agtccaacga ggaccccttc 300 accttcggcc agggcaccaa
gctggagatc aag 333 <210> SEQ ID NO 111 <211> LENGTH:
111 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 111 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Met Asn
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Phe Leu Ile
Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80
Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 85
90 95 Glu Asp Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110 <210> SEQ ID NO 112 <211> LENGTH: 333
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 112 gacatccagc tgacccagtc cccctcctcc
ctgtccgcct ccgtgggcga ccgcgtgacc 60 atcacctgca aggcctccca
gtccgtggac tacgacggcg actcctacat gaactggtac 120 cagcagaagc
ccggcaaggc ccccaagttc ctgatctgcg ccgcctccaa cctggagtcc 180
ggcgtgccct cccgcttctc cggctccggc tccggcaccg acttcaccct gaccatctcc
240 tccctgcagc ccgaggactt cgccacctac tactgccagc agtccaacga
ggaccccttc 300 accttcggcc agggcaccaa gctggagatc aag 333 <210>
SEQ ID NO 113 <211> LENGTH: 111 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
113 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
Tyr Asp 20 25 30 Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro
Gly Lys Ala Pro 35 40 45 Lys Phe Leu Ile Cys Ala Ala Ser Asn Leu
Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp
Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 85 90 95 Glu Asp Pro Phe
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210>
SEQ ID NO 114 <211> LENGTH: 333 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
114 gacatccagc tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga
ccgcgtgacc 60 atcacctgca aggcctccca gtccgtggac tacgacggcg
actcctacat gaactggtac 120 cagcagaagc ccggcaaggc ccccaagttc
ctgatctacg ccgcctccaa cctggagtcc 180 ggcgtgccct cccgcttctc
cggctccggc tccggcaccg acttcaccct gaccatctcc 240 tccctgcagc
ccgaggactt cgccacctac tactgccagc agtccaacga ggaccccttc 300
accttcggcc agggcaccaa gctggagatc aag 333 <210> SEQ ID NO 115
<211> LENGTH: 111 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 115 Asp Ile Gln Leu
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg
Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35
40 45 Lys Phe Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro
Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
Cys Gln Gln Ser Asn 85 90 95 Glu Asp Pro Phe Thr Phe Gly Gln Gly
Thr Lys Leu Glu Ile Lys 100 105 110 <210> SEQ ID NO 116
<211> LENGTH: 66 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 116 atggacatgc
gcgtgcccgc ccagctgctg ggcctgctga tgctgtgggt gtccggctcc 60 tccggc 66
<210> SEQ ID NO 117 <211> LENGTH: 117 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
117 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
Ser Phe 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Pro Tyr Asn Gly Asp Thr
Asn Tyr Ala Gln Asn Leu 50 55 60 Gln Gly Arg Val Thr Met Thr Thr
Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu
Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg
Gly Ser Met Ser Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr
Val Ser Ser 115 <210> SEQ ID NO 118 <211> LENGTH: 107
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 118 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser
Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Pro 85
90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105
<210> SEQ ID NO 119 <211> LENGTH: 117 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
119 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr
Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr
Lys Tyr Ser Glu Lys Phe 50 55 60 Lys Gly Arg Val Thr Met Thr Thr
Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu
Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly
Cys Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr
Val Ser Ser 115 <210> SEQ ID NO 120 <211> LENGTH: 111
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 120 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Met Asn
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile
Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 85
90 95 Glu Asp Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110 <210> SEQ ID NO 121 <211> LENGTH: 117
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa = V or L
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (28)..(28) <223> OTHER INFORMATION: Xaa = S or T
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (38)..(38) <223> OTHER INFORMATION: Xaa = R or K
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (48)..(48) <223> OTHER INFORMATION: Xaa = M or I
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (68)..(68) <223> OTHER INFORMATION: Xaa = V or A
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (70)..(70) <223> OTHER INFORMATION: Xaa = M or L
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (72)..(72) <223> OTHER INFORMATION: Xaa = T or A
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (95)..(95) <223> OTHER INFORMATION: Xaa = Y or F
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (101)..(101) <223> OTHER INFORMATION: Xaa = C or S
<400> SEQUENCE: 121 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Xaa Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Xaa Phe Thr Ser Tyr 20 25 30 Tyr Ile His Trp Val Xaa
Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa 35 40 45 Gly Trp Ile Tyr
Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu Lys Phe 50 55 60 Lys Gly
Arg Xaa Thr Xaa Thr Xaa Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Xaa Cys 85
90 95 Ala Arg Asp Gly Xaa Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr
Leu 100 105 110 Val Thr Val Ser Ser 115 <210> SEQ ID NO 122
<211> LENGTH: 111 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (50)..(50) <223> OTHER
INFORMATION: Xaa = L or F <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (53)..(53) <223>
OTHER INFORMATION: Xaa = Y or C <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (87)..(87) <223>
OTHER INFORMATION: Xaa = F or A <400> SEQUENCE: 122 Asp Ile
Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20
25 30 Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
Pro 35 40 45 Lys Xaa Leu Ile Xaa Ala Ala Ser Asn Leu Glu Ser Gly
Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp Xaa Ala Thr
Tyr Tyr Cys Gln Gln Ser Asn 85 90 95 Glu Asp Pro Phe Thr Phe Gly
Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> SEQ ID NO
123 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (3)..(3) <223> OTHER
INFORMATION: Xaa = C or M or S or T <400> SEQUENCE: 123 Asp
Gly Xaa Tyr Gly Phe Ala Tyr 1 5 <210> SEQ ID NO 124
<211> LENGTH: 218 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 124 Asp Ile Gln Leu
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg
Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35
40 45 Lys Phe Leu Ile Cys Ala Ala Ser Asn Leu Glu Ser Gly Val Pro
Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
Cys Gln Gln Ser Asn 85 90 95 Glu Asp Pro Phe Thr Phe Gly Gln Gly
Thr Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val
Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165
170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu
Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210
215 <210> SEQ ID NO 125 <211> LENGTH: 217 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 125 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln
Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Met Asn Trp Tyr Gln
Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Phe Leu Ile Cys Ala Ala
Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 85 90 95 Glu
Asp Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr 100 105
110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu
115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln
Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr
Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys
Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser
Phe Asn Arg Gly Glu Cys 210 215 <210> SEQ ID NO 126
<211> LENGTH: 447 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 126 Gln Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val
Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35
40 45 Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu Lys
Phe 50 55 60 Lys Gly Arg Ala Thr Met Thr Ala Asp Thr Ser Thr Ser
Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Cys Tyr Gly Phe Ala
Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser Ala Ser
Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125 Ala Pro Ser Ser Lys
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 145 150 155 160
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 165
170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
Ser 180 185 190 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser
Cys Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu
Leu Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Val Lys 275 280 285
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290
295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Glu Glu Met Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410
415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
Lys 435 440 445 <210> SEQ ID NO 127 <211> LENGTH: 447
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 127 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr
Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu Lys Phe 50 55 60 Lys Gly
Arg Ala Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Asp Gly Cys Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr
Leu 100 105 110 Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
Phe Pro Leu 115 120 125 Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys Asp Tyr Phe Pro Glu Pro
Val Thr Val Ser Trp Asn Ser 145 150 155 160 Gly Ala Leu Thr Ser Gly
Val His Thr Phe Pro Ala Val Leu Gln Ser 165 170 175 Ser Gly Leu Tyr
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 180 185 190 Leu Gly
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 195 200 205
Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 210
215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val
Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 325 330
335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
340 345 350 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445
<210> SEQ ID NO 128 <211> LENGTH: 326 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
128 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys
Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln
Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro
Ser Ser Asn Phe Gly Thr Gln Thr 65 70 75 80 Tyr Thr Cys Asn Val Asp
His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Thr Val Glu Arg
Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 100 105 110 Pro Val
Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 115 120 125
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 130
135 140 Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
Gly 145 150 155 160 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
Glu Gln Phe Asn 165 170 175 Ser Thr Phe Arg Val Val Ser Val Leu Thr
Val Val His Gln Asp Trp 180 185 190 Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val Ser Asn Lys Gly Leu Pro 195 200 205 Ala Pro Ile Glu Lys Thr
Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 210 215 220 Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 225 230 235 240 Gln
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 245 250
255 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
260 265 270 Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
Ser Lys 275 280 285 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
Val Phe Ser Cys 290 295 300 Ser Val Met His Glu Ala Leu His Asn His
Tyr Thr Gln Lys Ser Leu 305 310 315 320 Ser Leu Ser Pro Gly Lys 325
<210> SEQ ID NO 129 <211> LENGTH: 330 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
129 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln
Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro
Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn
His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130
135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250
255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 325 330 <210> SEQ ID NO 130 <211> LENGTH:
113 <212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 130 Glu Val Gln Leu Val Gln Ser Gly Gly Gly
Leu Val Glu Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Val
Ser Gly Phe Asp Phe Glu Lys Ala 20 25 30 Trp Met Ser Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 35 40 45 Ala Arg Ile Lys
Ser Thr Ala Asp Gly Gly Thr Thr Ser Tyr Ala Ala 50 55 60 Pro Val
Glu Gly Arg Phe Ile Ile Ser Arg Asp Asp Ser Arg Asn Met 65 70 75 80
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85
90 95 Tyr Cys Thr Ser Ala His Trp Gly Gln Gly Thr Leu Val Thr Val
Ser 100 105 110 Ser <210> SEQ ID NO 131 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 131 Lys Ala Trp Met Ser 1 5 <210> SEQ
ID NO 132 <211> LENGTH: 19 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 132 Arg Ile
Lys Ser Thr Ala Asp Gly Gly Thr Thr Ser Tyr Ala Ala Pro 1 5 10 15
Val Glu Gly <210> SEQ ID NO 133 <400> SEQUENCE: 133 000
<210> SEQ ID NO 134 <211> LENGTH: 108 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
134 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1 5 10 15 Thr Ala Arg Ile Thr Cys Ser Gly Glu Ala Leu Pro Met Gln
Phe Ala 20 25 30 His Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Val
Ile Val Val Tyr 35 40 45 Lys Asp Ser Glu Arg Pro Ser Gly Val Pro
Glu Arg Phe Ser Gly Ser 50 55 60 Ser Ser Gly Thr Thr Ala Thr Leu
Thr Ile Thr Gly Val Gln Ala Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr
Cys Gln Ser Pro Asp Ser Thr Asn Thr Tyr 85 90 95 Glu Val Phe Gly
Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> SEQ ID NO 135
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 135 Ser Gly Glu Ala
Leu Pro Met Gln Phe Ala His 1 5 10 <210> SEQ ID NO 136
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 136 Lys Asp Ser Glu
Arg Pro Ser 1 5 <210> SEQ ID NO 137 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 137 Gln Ser Pro Asp Ser Thr Asn Thr Tyr Glu
Val 1 5 10 <210> SEQ ID NO 138 <211> LENGTH: 124
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 138 Glu Val Gln Leu Val Glu Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Ala Met His Trp Val Arg
Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn
Ala Gly Asn Gly Lys Arg Lys Tyr Ser Gln Lys Phe 50 55 60 Gln Asp
Arg Val Thr Ile Asn Arg Asp Thr Ser Ala Ser Thr Ile Tyr 65 70 75 80
Met Glu Leu Ser Ser Leu Gly Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Glu Glu Asp His Ala Gly Ser Gly Ser Tyr Leu Ser Met
Asp 100 105 110 Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115
120 <210> SEQ ID NO 139 <211> LENGTH: 5 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 139 Asn Tyr Ala Met His 1 5 <210> SEQ ID NO 140
<211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 140 Trp Ile Asn Ala
Gly Asn Gly Lys Arg Lys Tyr Ser Gln Lys Phe Gln 1 5 10 15 Asp
<210> SEQ ID NO 141 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
141 Glu Glu Asp His Ala Gly Ser Gly Ser Tyr Leu Ser Met Asp Val 1 5
10 15 <210> SEQ ID NO 142 <211> LENGTH: 113 <212>
TYPE: PRT <213> ORGANISM: Artificial sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 142 Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val
Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln
Asn Val Leu Tyr Ser 20 25 30 Ser Asn Asn Lys Asn Tyr Leu Ala Trp
Tyr Gln Gln Lys Pro Gly His 35 40 45 Pro Pro Lys Leu Leu Ile Tyr
Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Thr Ser
Leu Gln Thr Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 85 90 95 Tyr
Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 100 105
110 Lys <210> SEQ ID NO 143 <211> LENGTH: 17
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 143 Lys Ser Ser Gln Asn Val Leu Tyr Ser Ser
Asn Asn Lys Asn Tyr Leu 1 5 10 15 Ala <210> SEQ ID NO 144
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 144 Trp Ala Ser Thr
Arg Glu Ser 1 5 <210> SEQ ID NO 145 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 145 Gln Gln Tyr Tyr Ser Ser Pro Leu Thr 1 5
<210> SEQ ID NO 146 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
146 Asn Tyr Gly Met Ser 1 5 <210> SEQ ID NO 147 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 147 Ser Ile Ser Ser Gly Gly Gly
Ser Thr Tyr Tyr Pro Asp Asn Val Lys 1 5 10 15 Gly <210> SEQ
ID NO 148 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 148 Gly Gly
Ala Gly Ile Asp Tyr 1 5 <210> SEQ ID NO 149 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 149 Lys Ser Ile Gln Thr Leu Leu
Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 1 5 10 15 Ala <210> SEQ
ID NO 150 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Artificial sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 150 Trp Ala
Ser Ile Arg Lys Ser 1 5 <210> SEQ ID NO 151 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 151 Gln Gln Tyr Tyr Ser Tyr Pro
Leu Thr 1 5
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 151
<210> SEQ ID NO 1 <211> LENGTH: 113 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 1
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 1 5
10 15 Glu Lys Val Thr Met Ser Cys Lys Ser Ile Gln Thr Leu Leu Tyr
Ser 20 25 30 Ser Asn Gln Lys Asn Tyr Leu Ala Trp Phe Gln Gln Lys
Pro Gly Gln 35 40 45 Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile
Arg Lys Ser Gly Val 50 55 60 Pro Asp Arg Phe Thr Gly Ser Gly Ser
Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Val Lys Ala Glu
Asp Leu Ala Val Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Ser Tyr Pro
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 100 105 110 Lys
<210> SEQ ID NO 2 <211> LENGTH: 107 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 2
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5
10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser
Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro
Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr
Cys Gln Gln Ser Tyr Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gly Gly
Thr Lys Leu Glu Ile Lys 100 105 <210> SEQ ID NO 3 <211>
LENGTH: 113 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 3 Asp Ile Gln Met Thr Gln Ser Pro
Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr
Cys Lys Ser Ile Gln Thr Leu Leu Tyr Ser 20 25 30 Ser Asn Gln Lys
Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 35 40 45 Ala Pro
Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Lys Ser Gly Val 50 55 60
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65
70 75 80 Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
Gln Gln 85 90 95 Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile 100 105 110 Lys <210> SEQ ID NO 4 <211>
LENGTH: 113 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 4 Asp Ile Gln Met Thr Gln Ser Pro
Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr
Cys Lys Ser Ile Gln Thr Leu Leu Tyr Ser 20 25 30 Ser Asn Gln Lys
Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 35 40 45 Ala Pro
Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Lys Ser Gly Val 50 55 60
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65
70 75 80 Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
Gln Gln 85 90 95 Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile 100 105 110 Lys <210> SEQ ID NO 5 <211>
LENGTH: 113 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 5 Asp Ile Gln Met Thr Gln Ser Pro
Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr
Cys Lys Ser Ile Gln Thr Leu Leu Tyr Ser 20 25 30 Ser Asn Gln Lys
Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 35 40 45 Ala Pro
Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Lys Ser Gly Val 50 55 60
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65
70 75 80 Ile Ser Ser Leu Gln Pro Glu Asp Leu Ala Thr Tyr Tyr Cys
Gln Gln 85 90 95 Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile 100 105 110 Lys <210> SEQ ID NO 6 <211>
LENGTH: 116 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 6 Glu Val Lys Leu Val Glu Ser Gly
Gly Gly Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Leu Lys Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met Ser Trp
Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val 35 40 45 Ala Ser
Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Asn Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Glu Asp Ala Lys Asn Thr Leu Tyr 65
70 75 80 Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr
Tyr Cys 85 90 95 Ser Arg Gly Gly Ala Gly Ile Asp Tyr Trp Gly Gln
Gly Thr Thr Leu 100 105 110 Thr Val Ser Ser 115 <210> SEQ ID
NO 7 <211> LENGTH: 116 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 7 Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25
30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp
Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys
Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Ser Ser Asp Met Asp
Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115
<210> SEQ ID NO 8 <211> LENGTH: 116 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 8
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn
Tyr
20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
Trp Val 35 40 45 Ala Ser Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr
Pro Asp Asn Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp
Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala
Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ser Arg Gly Gly Ala Gly
Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser
115 <210> SEQ ID NO 9 <211> LENGTH: 116 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 9 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro
Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr
Phe Ser Asn Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ser Ser Gly Gly Gly
Ser Thr Tyr Tyr Pro Asp Asn Val 50 55 60 Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ser Arg
Gly Gly Ala Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110
Thr Val Ser Ser 115 <210> SEQ ID NO 10 <211> LENGTH:
116 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 10 Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ser
Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Asn Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Gly Gly Ala Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu
Val 100 105 110 Thr Val Ser Ser 115 <210> SEQ ID NO 11
<211> LENGTH: 116 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 11 Glu Val Gln Leu
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35
40 45 Ala Ser Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Asn
Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ala Gly Ile Asp Tyr
Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115
<210> SEQ ID NO 12 <211> LENGTH: 140 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 12 Met
Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 1 5 10
15 Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys
20 25 30 Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu
Gly Val 35 40 45 Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys
Glu Gln Val Thr 50 55 60 Asn Val Gly Gly Ala Val Val Thr Gly Val
Thr Ala Val Ala Gln Lys 65 70 75 80 Thr Val Glu Gly Ala Gly Ser Ile
Ala Ala Ala Thr Gly Phe Val Lys 85 90 95 Lys Asp Gln Leu Gly Lys
Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 100 105 110 Leu Glu Asp Met
Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 115 120 125 Ser Glu
Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 130 135 140 <210> SEQ
ID NO 13 <211> LENGTH: 107 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 13 Arg Thr Val
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 1 5 10 15 Gln
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 20 25
30 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
35 40 45 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys
Asp Ser 50 55 60 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
Ala Asp Tyr Glu 65 70 75 80 Lys His Lys Val Tyr Ala Cys Glu Val Thr
His Gln Gly Leu Ser Ser 85 90 95 Pro Val Thr Lys Ser Phe Asn Arg
Gly Glu Cys 100 105 <210> SEQ ID NO 14 <211> LENGTH:
324 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 14 cgaaactgtg gctgcaccat ctgtcttcat
cttcccgcca tctgatgagc agttgaaatc 60 tggaactgcc tctgttgtgt
gcctgctgaa taacttctat cccagagagg ccaaagtaca 120 gtggaaggtg
gataacgccc tccaatcggg taactcccag gagagtgtca cagagcagga 180
cagcaaggac agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga
240 gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc
ccgtcacaaa 300 gagctcaaca ggggagagtg ttag 324 <210> SEQ ID NO
15 <211> LENGTH: 330 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 15 Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25
30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu
Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu
Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser
Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro Lys Ser Cys Asp
Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155
160 Tyr Val Asp Gly Val Glu Val His Asn Val Lys Thr Lys Pro Arg
Glu
165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280
285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325
330 <210> SEQ ID NO 16 <211> LENGTH: 991 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 16 gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag
cacctctggg 60 ggcacagcgg ccctgggctg cctggtcaag gactacttcc
ccgaaccggt gacggtgtcg 120 tggaactcag gcgccctgac cagcggcgtg
cacaccttcc cggctgtcct acagtcctca 180 ggactctact ccctcagcag
cgtggtgacc gtgccctcca gcagcttggg cacccagacc 240 acatctgcaa
cgtgaatcac aagcccagca acaccaaggt ggacaagaga gttgagccca 300
aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc ctggggggac
360 cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc
cggacccctg 420 aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc
tgaggtcaag ttcaactggt 480 acgtggacgg cgtggaggtg cataatgtca
agacaaagcc gcgggaggag cagtacaaca 540 gcacgtaccg tgtggtcagc
gtcctcaccg tcctgcacca ggactggctg aatggcaagg 600 agtacaagtg
caaggtctcc aacaaagccc tcccagcccc catcgagaaa accatctcca 660
aagccaaagg gcagccccga gaaccacagg tgtacacgct gcccccatcc cgggaggaga
720 tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc
agcgacatcg 780 cgtggagtgg gagagcaatg ggcagccgga gaacaactac
aagaccacgc ctcccgtgct 840 ggactccgac ggctccttct tcctctatag
caagctcacc gtggacaaga gcaggtggca 900 gcaggggaac gtcttctcat
gctccgtgat gcatgaggct ctgcacaacc actacacgca 960 gaagagcctc
tccctgtccc cgggtaaatg a 991 <210> SEQ ID NO 17 <211>
LENGTH: 339 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 17 gacatccaga tgacccagtc
cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc 60 atcacctgca
agtccatcca gaccctgctg tactcctcca accagaagaa ctacctggcc 120
tggttccagc agaagcccgg caaggccccc aagctgctga tctactgggc ctccatccgc
180 aagtccggcg tgccctcccg cttctccggc tccggctccg gcaccgactt
caccctgacc 240 atctcctccc tgcagcccga ggacttcgcc acctactact
gccagcagta ctactcctac 300 cccctgacct tcggcggcgg caccaagctg
gagatcaag 339 <210> SEQ ID NO 18 <211> LENGTH: 339
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 18 gacatccaga tgacccagtc cccctcctcc
ctgtccgcct ccgtgggcga ccgcgtgacc 60 atcacctgca agtccatcca
gaccctgctg tactcctcca accagaagaa ctacctggcc 120 tggtaccagc
agaagcccgg caaggccccc aagctgctga tctactgggc ctccatccgc 180
aagtccggcg tgccctcccg cttctccggc tccggctccg gcaccgactt caccctgacc
240 atctcctccc tgcagcccga ggacttcgcc acctactact gccagcagta
ctactcctac 300 cccctgacct tcggcggcgg caccaagctg gagatcaag 339
<210> SEQ ID NO 19 <211> LENGTH: 339 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 19
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc
60 atcacctgca agtccatcca gaccctgctg tactcctcca accagaagaa
ctacctggcc 120 tggttccagc agaagcccgg caaggccccc aagctgctga
tctactgggc ctccatccgc 180 aagtccggcg tgccctcccg cttctccggc
tccggctccg gcaccgactt caccctgacc 240 atctcctccc tgcagcccga
ggacctggcc acctactact gccagcagta ctactcctac 300 cccctgacct
tcggcggcgg caccaagctg gagatcaag 339 <210> SEQ ID NO 20
<211> LENGTH: 348 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 20 gaggtgcagc
tggtggagtc cggcggcggc ctggtgcagc ccggcggctc cctgcgcctg 60
tcctgcgccg cctccggctt caccttctcc aactacggca tgtcctgggt gcgccaggcc
120 cccggcaagg gcctggagtg ggtggcctcc atctcctccg gcggcggctc
cacctactac 180 cccgacaacg tgaagggccg cttcaccatc tcccgcgacg
acgccaagaa ctccctgtac 240 ctgcagatga actccctgcg cgccgaggac
accgccgtgt actactgctc ccgcggcggc 300 gccggcatcg actactgggg
ccagggcacc ctggtgaccg tgtcctcc 348 <210> SEQ ID NO 21
<211> LENGTH: 348 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 21 gaggtgcagc
tggtggagtc cggcggcggc ctggtgcagc ccggcggctc cctgcgcctg 60
tcctgcgccg cctccggctt caccttctcc aactacggca tgtcctgggt gcgccaggcc
120 cccggcaagg gcctggagtg ggtggcctcc atctcctccg gcggcggctc
cacctactac 180 cccgacaacg tgaagggccg cttcaccatc tcccgcgaca
acgccaagaa ctccctgtac 240 ctgcagatga actccctgcg cgccgaggac
accgccgtgt actactgctc ccgcggcggc 300 gccggcatcg actactgggg
ccagggcacc ctggtgaccg tgtcctcc 348 <210> SEQ ID NO 22
<211> LENGTH: 348 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 22 gaggtgcagc
tggtggagtc cggcggcggc ctggtgcagc ccggcggctc cctgcgcctg 60
tcctgcgccg cctccggctt caccttctcc aactacggca tgtcctgggt gcgccaggcc
120 cccggcaagg gcctggagtg ggtggcctcc atctcctccg gcggcggctc
cacctactac 180 cccgacaacg tgaagggccg cttcaccatc tcccgcgacg
acgccaagaa ctccctgtac 240 ctgcagatga actccctgcg cgccgaggac
accgccgtgt actactgcgc ccgcggcggc 300 gccggcatcg actactgggg
ccagggcacc ctggtgaccg tgtcctcc 348 <210> SEQ ID NO 23
<211> LENGTH: 348 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 23 gaggtgcagc
tggtggagtc cggcggcggc ctggtgcagc ccggcggctc cctgcgcctg 60
tcctgcgccg cctccggctt caccttctcc aactacggca tgtcctgggt gcgccaggcc
120 cccggcaagg gcctggagtg ggtggcctcc atctcctccg gcggcggctc
cacctactac 180 cccgacaacg tgaagggccg cttcaccatc tcccgcgaca
acgccaagaa ctccctgtac 240 ctgcagatga actccctgcg cgccgaggac
accgccgtgt actactgcgc ccgcggcggc 300 gccggcatcg actactgggg
ccagggcacc ctggtgaccg tgtcctcc 348 <210> SEQ ID NO 24
<211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 24 Met Asp Met Arg
Val Pro Ala Gln Leu Leu Gly Leu Leu Met Leu Trp 1 5 10 15 Val Ser
Gly Ser Ser Gly 20 <210> SEQ ID NO 25 <211> LENGTH: 66
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 25 atggacatgc gcgtgcccgc ccagctgctg
ggcctgctga tgctgtgggt gtccggctcc 60 tccggc 66 <210> SEQ ID NO
26 <211> LENGTH: 19 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 26 Met Glu Phe
Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 1 5 10 15 Val
Gln Cys <210> SEQ ID NO 27 <211> LENGTH: 57 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 27 atggagttcg gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt
gcagtgc 57 <210> SEQ ID NO 28 <211> LENGTH: 113
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (42)..(42) <223> OTHER INFORMATION: Xaa = Y or F
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (89)..(89) <223> OTHER INFORMATION: Xaa = F or L
<400> SEQUENCE: 28 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys
Ser Ile Gln Thr Leu Leu Tyr Ser 20 25 30 Ser Asn Gln Lys Asn Tyr
Leu Ala Trp Xaa Gln Gln Lys Pro Gly Lys 35 40 45 Ala Pro Lys Leu
Leu Ile Tyr Trp Ala Ser Ile Arg Lys Ser Gly Val 50 55 60 Pro Ser
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80
Ile Ser Ser Leu Gln Pro Glu Asp Xaa Ala Thr Tyr Tyr Cys Gln Gln 85
90 95 Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
Ile 100 105 110 Lys <210> SEQ ID NO 29 <211> LENGTH:
116 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (74)..(74) <223> OTHER INFORMATION: Xaa = N or D
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (97)..(97) <223> OTHER INFORMATION: Xaa = A or S
<400> SEQUENCE: 29 Glu Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ser
Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Asn Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Xaa Ala Lys Asn Ser Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Xaa Arg Gly Gly Ala Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu
Val 100 105 110 Thr Val Ser Ser 115 <210> SEQ ID NO 30
<211> LENGTH: 106 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 30 Thr Val Ala Ala
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 1 5 10 15 Leu Lys
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 20 25 30
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 35
40 45 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
Thr 50 55 60 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
Tyr Glu Lys 65 70 75 80 His Lys Val Tyr Ala Cys Glu Val Thr His Gln
Gly Leu Ser Ser Pro 85 90 95 Val Thr Lys Ser Phe Asn Arg Gly Glu
Cys 100 105 <210> SEQ ID NO 31 <211> LENGTH: 321
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 31 aactgtggct gcaccatctg tcttcatctt
cccgccatct gatgagcagt tgaaatctgg 60 aactgcctct gttgtgtgcc
tgctgaataa cttctatccc agagaggcca aagtacagtg 120 gaaggtggat
aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag 180
caaggacagc acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa
240 acacaaagtc tacgcctgcg aagtcaccca tcagggcctg agctcgcccg
tcacaaagag 300 ctcaacaggg gagagtgtta g 321 <210> SEQ ID NO 32
<211> LENGTH: 220 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 32 Asp Ile Gln Met
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg
Val Thr Ile Thr Cys Lys Ser Ile Gln Thr Leu Leu Tyr Ser 20 25 30
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 35
40 45 Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Lys Ser Gly
Val 50 55 60 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Pro Glu Asp Leu Ala Thr
Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly
Gly Gly Thr Lys Leu Glu Ile 100 105 110 Lys Arg Thr Val Ala Ala Pro
Ser Val Phe Ile Phe Pro Pro Ser Asp 115 120 125 Glu Gln Leu Lys Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 130 135 140 Phe Tyr Pro
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 145 150 155 160
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 165
170 175 Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
Tyr 180 185 190 Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln
Gly Leu Ser 195 200 205 Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
Cys 210 215 220 <210> SEQ ID NO 33 <211> LENGTH: 219
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 33 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys
Ser Ile Gln Thr Leu Leu Tyr Ser 20 25 30 Ser Asn Gln Lys Asn Tyr
Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 35 40 45 Ala Pro Lys Leu
Leu Ile Tyr Trp Ala Ser Ile Arg Lys Ser Gly Val 50 55 60 Pro Ser
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80
Ile Ser Ser Leu Gln Pro Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln 85
90 95
Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 100
105 110 Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
Glu 115 120 125 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
Asn Asn Phe 130 135 140 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val
Asp Asn Ala Leu Gln 145 150 155 160 Ser Gly Asn Ser Gln Glu Ser Val
Thr Glu Gln Asp Ser Lys Asp Ser 165 170 175 Thr Tyr Ser Leu Ser Ser
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 180 185 190 Lys His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 195 200 205 Pro Val
Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> SEQ ID NO
34 <211> LENGTH: 446 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 34 Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25
30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 Ala Ser Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp
Asn Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys
Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ala Gly Ile Asp
Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser Ala Ser
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 115 120 125 Pro Ser Ser Lys
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 130 135 140 Val Lys
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 145 150 155
160 Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
165 170 175 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
Ser Leu 180 185 190 Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
Pro Ser Asn Thr 195 200 205 Lys Val Asp Lys Arg Val Glu Pro Lys Ser
Cys Asp Lys Thr His Thr 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu
Leu Leu Gly Gly Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 260 265 270 Lys
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Val Lys Thr 275 280
285 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
290 295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
Lys Cys 305 310 315 320 Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro 340 345 350 Ser Arg Glu Glu Met Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val 355 360 365 Lys Gly Phe Tyr Pro
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375 380 Gln Pro Glu
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 385 390 395 400
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 405
410 415 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His 420 425 430 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
Lys 435 440 445 <210> SEQ ID NO 35 <211> LENGTH: 330
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 35 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala
Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85
90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210
215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> SEQ ID NO
36 <211> LENGTH: 446 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 36 Glu Val Gln
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25
30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45 Ala Ser Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp
Asn Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys
Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ala Gly Ile Asp
Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser Ala Ser
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 115 120 125 Pro Ser Ser Lys
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 130 135 140 Val Lys
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 145 150 155
160 Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
165 170 175 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
Ser Leu 180 185 190 Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
Pro Ser Asn Thr 195 200 205 Lys Val Asp Lys Arg Val Glu Pro Lys Ser
Cys Asp Lys Thr His Thr 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu
Leu Leu Gly Gly Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
260 265 270 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Val
Lys Thr 275 280 285 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
Val Val Ser Val 290 295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn
Gly Lys Glu Tyr Lys Cys 305 310 315 320 Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 340 345 350 Ser Arg Glu
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 355 360 365 Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375
380 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
385 390 395 400 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
Ser Arg Trp 405 410 415 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
His Glu Ala Leu His 420 425 430 Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser Pro Gly Lys 435 440 445 <210> SEQ ID NO 37
<211> LENGTH: 446 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 37 Glu Val Gln Leu
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35
40 45 Ala Ser Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Asn
Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn
Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ala Gly Ile Asp Tyr
Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser Ala Ser Thr
Lys Gly Pro Ser Val Phe Pro Leu Ala 115 120 125 Pro Ser Ser Lys Ser
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 130 135 140 Val Lys Asp
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 145 150 155 160
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 165
170 175 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
Leu 180 185 190 Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
Ser Asn Thr 195 200 205 Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys
Asp Lys Thr His Thr 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu Leu
Leu Gly Gly Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys Pro
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr Cys
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 260 265 270 Lys Phe
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 275 280 285
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 290
295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
Cys 305 310 315 320 Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro 340 345 350 Ser Arg Glu Glu Met Thr Lys Asn
Gln Val Ser Leu Thr Cys Leu Val 355 360 365 Lys Gly Phe Tyr Pro Ser
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375 380 Gln Pro Glu Asn
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 385 390 395 400 Gly
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 405 410
415 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
420 425 430 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
435 440 445 <210> SEQ ID NO 38 <211> LENGTH: 345
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 38 caggtccagc tgcagcagtc tggggctgaa
ctggcaaaac ctgggacctc agtgcagatg 60 tcctgcaagg cttctggcta
cacctttact aattactgga tgaactggat aaaagcgagg 120 cctggacagg
gtctggaatg gattggggct actaatccta acaatggtta tactgactac 180
aatcagaggt tcaaggacaa ggccatatta actgcagaca aatcctccaa tacagcctac
240 atgcacctga gcagcctgac atctgaagac tctgcagtct atttctgtgc
aagtgggggg 300 cacttggctt actggggcca ggggactgtg gtcactgtct ctgca
345 <210> SEQ ID NO 39 <211> LENGTH: 115 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 39 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys
Pro Gly Thr 1 5 10 15 Ser Val Gln Met Ser Cys Lys Ala Ser Gly Tyr
Thr Phe Thr Asn Tyr 20 25 30 Trp Met Asn Trp Ile Lys Ala Arg Pro
Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ala Thr Asn Pro Asn Asn
Gly Tyr Thr Asp Tyr Asn Gln Arg Phe 50 55 60 Lys Asp Lys Ala Ile
Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 65 70 75 80 Met His Leu
Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala
Ser Gly Gly His Leu Ala Tyr Trp Gly Gln Gly Thr Val Val Thr 100 105
110 Val Ser Ala 115 <210> SEQ ID NO 40 <211> LENGTH: 57
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 40 atggaaaggc actggatctt tctcttcctg
ttatcagtaa ctggaggtgt ccactcc 57 <210> SEQ ID NO 41
<211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 41 Met Glu Arg His
Trp Ile Phe Leu Phe Leu Leu Ser Val Thr Gly Gly 1 5 10 15 Val His
Ser <210> SEQ ID NO 42 <211> LENGTH: 336 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 42 gatgttgtga tgacccaaat tccactctac ctgtctgtca gtcctggaga
tcaagcctcc 60 atctcttgca gatctagtca gagccttttc catagtaaag
gaaacaccta tttacattgg 120 tatctgcaga agccaggcca gtctccaaag
ctcctgatca acagggtttc caaccgattt 180 tctggggtcc cagacaggtt
cagtggcagt ggatcaggga cagatttcac actcaagatc 240 agcggagtgg
aggctgaaga tctgggagtt tatttctgtt ctcaaagtgc acatgttccg 300
tggacgttcg gtggaggcac caagctggaa atcaga 336 <210> SEQ ID NO
43 <211> LENGTH: 112 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 43 Asp Val Val
Met Thr Gln Ile Pro Leu Tyr Leu Ser Val Ser Pro Gly 1 5 10 15 Asp
Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Phe His Ser 20 25
30 Lys Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln
Ser
35 40 45 Pro Lys Leu Leu Ile Asn Arg Val Ser Asn Arg Phe Ser Gly
Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
Thr Leu Lys Ile 65 70 75 80 Ser Gly Val Glu Ala Glu Asp Leu Gly Val
Tyr Phe Cys Ser Gln Ser 85 90 95 Ala His Val Pro Trp Thr Phe Gly
Gly Gly Thr Lys Leu Glu Ile Arg 100 105 110 <210> SEQ ID NO
44 <211> LENGTH: 60 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 44 atgaagttgc
ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat 60
<210> SEQ ID NO 45 <211> LENGTH: 20 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 45
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 1 5
10 15 Ser Ser Ser Asp 20 <210> SEQ ID NO 46 <211>
LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 46 Val Asp Pro Asp Asn Glu Ala
Tyr Glu Gly Gly Cys 1 5 10 <210> SEQ ID NO 47 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 47 Asn Tyr Trp Met Asn 1 5
<210> SEQ ID NO 48 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 48
Ala Thr Asn Pro Asn Asn Gly Tyr Thr Asp Tyr Asn Gln Arg Phe Lys 1 5
10 15 Asp <210> SEQ ID NO 49 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 49 Gly Gly His Leu Ala Tyr 1 5 <210>
SEQ ID NO 50 <211> LENGTH: 16 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 50
Arg Ser Ser Gln Ser Leu Phe His Ser Lys Gly Asn Thr Tyr Leu His 1 5
10 15 <210> SEQ ID NO 51 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 51 Arg Val Ser Asn Arg Phe Ser 1 5 <210> SEQ ID NO
52 <211> LENGTH: 9 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 52 Ser Gln Ser
Ala His Val Pro Trp Thr 1 5 <210> SEQ ID NO 53 <211>
LENGTH: 402 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 53 atggaaaggc actggatctt
tctcttcctg ttatcagtaa ctggaggtgt ccactcccag 60 gtccagctgc
agcagtctgg ggctgaactg gcaaaacctg ggacctcagt gcagatgtcc 120
tgcaaggctt ctggctacac ctttactaat tactggatga actggataaa agcgaggcct
180 ggacagggtc tggaatggat tggggctact aatcctaaca atggttatac
tgactacaat 240 cagaggttca aggacaaggc catattaact gcagacaaat
cctccaatac agcctacatg 300 cacctgagca gcctgacatc tgaagactct
gcagtctatt tctgtgcaag tggggggcac 360 ttggcttact ggggccaggg
gactgtggtc actgtctctg ca 402 <210> SEQ ID NO 54 <211>
LENGTH: 134 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 54 Met Glu Arg His Trp Ile Phe
Leu Phe Leu Leu Ser Val Thr Gly Gly 1 5 10 15 Val His Ser Gln Val
Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys 20 25 30 Pro Gly Thr
Ser Val Gln Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45 Thr
Asn Tyr Trp Met Asn Trp Ile Lys Ala Arg Pro Gly Gln Gly Leu 50 55
60 Glu Trp Ile Gly Ala Thr Asn Pro Asn Asn Gly Tyr Thr Asp Tyr Asn
65 70 75 80 Gln Arg Phe Lys Asp Lys Ala Ile Leu Thr Ala Asp Lys Ser
Ser Asn 85 90 95 Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu
Asp Ser Ala Val 100 105 110 Tyr Phe Cys Ala Ser Gly Gly His Leu Ala
Tyr Trp Gly Gln Gly Thr 115 120 125 Val Val Thr Val Ser Ala 130
<210> SEQ ID NO 55 <211> LENGTH: 393 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 55
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat
60 gttgtgatga cccaaattcc actctacctg tctgtcagtc ctggagatca
agcctccatc 120 tcttgcagat ctagtcagag ccttttccat agtaaaggaa
acacctattt acattggtat 180 ctgcagaagc caggccagtc tccaaagctc
ctgatcaaca gggtttccaa ccgattttct 240 ggggtcccag acaggttcag
tggcagtgga tcagggacag atttcacact caagatcagc 300 ggagtggagg
ctgaagatct gggagtttat ttctgttctc aaagtgcaca tgttccgtgg 360
acgttcggtg gaggcaccaa gctggaaatc aga 393 <210> SEQ ID NO 56
<211> LENGTH: 131 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 56 Met Lys Leu Pro
Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 1 5 10 15 Ser Ser
Ser Asp Val Val Met Thr Gln Ile Pro Leu Tyr Leu Ser Val 20 25 30
Ser Pro Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35
40 45 Phe His Ser Lys Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys
Pro 50 55 60 Gly Gln Ser Pro Lys Leu Leu Ile Asn Arg Val Ser Asn
Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser
Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Gly Val Glu Ala Glu
Asp Leu Gly Val Tyr Phe Cys 100 105 110
Ser Gln Ser Ala His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 115
120 125 Glu Ile Arg 130 <210> SEQ ID NO 57 <211>
LENGTH: 118 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 57 Gln Val Gln Leu Val Gln Ser
Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Tyr 20 25 30 Ala Ile Asn
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly
Gly Ile Ile Pro Ile Phe Gly Thr Thr Thr Tyr Ala Gln Lys Phe 50 55
60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr
65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Glu Gly Asn Leu Asn Trp Leu Asp Pro Trp
Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210>
SEQ ID NO 58 <211> LENGTH: 115 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 58
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 1 5
10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn
Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu Trp Ile 35 40 45 Gly Ala Thr Asn Pro Asn Asn Gly Tyr Thr Asp
Tyr Asn Gln Arg Phe 50 55 60 Lys Asp Arg Ala Thr Leu Thr Ala Asp
Lys Ser Thr Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg
Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly His
Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser
115 <210> SEQ ID NO 59 <211> LENGTH: 115 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 59 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys
Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
Thr Phe Thr Asn Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro
Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ala Thr Asn Pro Asn Asn
Gly Tyr Thr Asp Tyr Asn Gln Arg Phe 50 55 60 Lys Asp Arg Val Thr
Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Gly Gly His Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 100 105
110 Val Ser Ser 115 <210> SEQ ID NO 60 <211> LENGTH:
115 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 60 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Leu Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Met Asn Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ala Thr Asn
Pro Asn Asn Gly Tyr Thr Asp Tyr Asn Gln Arg Phe 50 55 60 Lys Asp
Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85
90 95 Ala Ser Gly Gly His Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val
Thr 100 105 110 Val Ser Ser 115 <210> SEQ ID NO 61
<211> LENGTH: 115 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 61 Gln Val Gln Leu
Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 1 5 10 15 Ser Val
Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35
40 45 Gly Ala Thr Asn Pro Asn Asn Gly Tyr Thr Asp Tyr Asn Gln Arg
Phe 50 55 60 Lys Asp Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Asn
Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Gly Gly His Leu Ala Tyr Trp
Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210>
SEQ ID NO 62 <211> LENGTH: 115 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 62
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 1 5
10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn
Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
Glu Trp Ile 35 40 45 Gly Ala Thr Asn Pro Asn Asn Gly Tyr Thr Asp
Tyr Asn Gln Arg Phe 50 55 60 Lys Asp Arg Val Thr Ile Thr Ala Asp
Lys Ser Thr Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg
Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Gly Gly His
Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser
115 <210> SEQ ID NO 63 <211> LENGTH: 402 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 63 atggagttcg gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt
gcagtgccag 60 gtgcagctgg tgcagtccgg cgccgagctg aagaagcccg
gctcctccgt gaaggtgtcc 120 tgcaaggcct ccggctacac cttcaccaac
tactggatga actgggtgcg ccaggccccc 180 ggccagggcc tggagtggat
cggcgccacc aaccccaaca acggctacac cgactacaac 240 cagcgcttca
aggaccgcgc caccctgacc gccgacaagt ccaccaacac cgcctacatg 300
gagctgtcct ccctgcgctc cgaggacacc gccgtgtact actgcgcccg cggcggccac
360 ctggcctact ggggccaggg caccctggtg accgtgtcct cc 402 <210>
SEQ ID NO 64 <211> LENGTH: 402 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 64
atggagttcg gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt gcagtgccag
60 gtgcagctgg tgcagtccgg cgccgagctg aagaagcccg gctcctccgt
gaaggtgtcc 120 tgcaaggcct ccggctacac cttcaccaac tactggatga
actgggtgcg ccaggccccc 180 ggccagggcc tggagtggat cggcgccacc
aaccccaaca acggctacac cgactacaac 240
cagcgcttca aggaccgcgt gaccatcacc gccgacaagt ccaccaacac cgcctacatg
300 gagctgtcct ccctgcgctc cgaggacacc gccgtgtact actgcgcccg
cggcggccac 360 ctggcctact ggggccaggg caccctggtg accgtgtcct cc 402
<210> SEQ ID NO 65 <211> LENGTH: 402 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 65
atggagttcg gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt gcagtgccag
60 gtgcagctgg tgcagtccgg cgccgagctg aagaagcccg gctcctccgt
gaaggtgtcc 120 tgcaaggcct ccggctacac cttcaccaac tactggatga
actgggtgcg ccaggccccc 180 ggccagggcc tggagtggat cggcgccacc
aaccccaaca acggctacac cgactacaac 240 cagcgcttca aggaccgcgc
caccctgacc gccgacaagt ccaccaacac cgcctacatg 300 gagctgtcct
ccctgcgctc cgaggacacc gccgtgtact tctgcgcctc cggcggccac 360
ctggcctact ggggccaggg caccctggtg accgtgtcct cc 402 <210> SEQ
ID NO 66 <211> LENGTH: 402 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 66 atggagttcg
gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt gcagtgccag 60
gtgcagctgg tgcagtccgg cgccgagctg aagaagcccg gctcctccgt gaaggtgtcc
120 tgcaaggcct ccggctacac cttcaccaac tactggatga actgggtgcg
ccaggccccc 180 ggccagggcc tggagtggat cggcgccacc aaccccaaca
acggctacac cgactacaac 240 cagcgcttca aggaccgcgc caccctgacc
gccgacaagt ccaccaacac cgcctacatg 300 gagctgtcct ccctgcgctc
cgaggacacc gccgtgtact actgcgcctc cggcggccac 360 ctggcctact
ggggccaggg caccctggtg accgtgtcct cc 402 <210> SEQ ID NO 67
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 67 atggagttcg
gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt gcagtgccag 60
gtgcagctgg tgcagtccgg cgccgagctg aagaagcccg gctcctccgt gaaggtgtcc
120 tgcaaggcct ccggctacac cttcaccaac tactggatga actgggtgcg
ccaggccccc 180 ggccagggcc tggagtggat cggcgccacc aaccccaaca
acggctacac cgactacaac 240 cagcgcttca aggaccgcgt gaccatcacc
gccgacaagt ccaccaacac cgcctacatg 300 gagctgtcct ccctgcgctc
cgaggacacc gccgtgtact actgcgccag cggcggccac 360 ctggcctact
ggggccaggg caccctggtg accgtgtcct cc 402 <210> SEQ ID NO 68
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 68 Asp Ile Val Met
Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro
Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35
40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val
Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Pro Thr Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> SEQ ID NO 69
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 69 Asp Val Val Met
Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Pro
Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Phe His Ser 20 25 30
Lys Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35
40 45 Pro Lys Leu Leu Ile Asn Arg Val Ser Asn Arg Phe Ser Gly Val
Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
Phe Cys Ser Gln Ser 85 90 95 Ala His Val Pro Trp Thr Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> SEQ ID NO 70
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 70 Asp Ile Val Met
Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Pro
Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Phe His Ser 20 25 30
Lys Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35
40 45 Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val
Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
Phe Cys Ser Gln Ser 85 90 95 Ala His Val Pro Trp Thr Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> SEQ ID NO 71
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 71 Asp Val Val Met
Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Pro
Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Phe His Ser 20 25 30
Lys Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35
40 45 Pro Gln Leu Leu Ile Asn Arg Val Ser Asn Arg Phe Ser Gly Val
Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
Phe Cys Ser Gln Ser 85 90 95 Ala His Val Pro Trp Thr Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> SEQ ID NO 72
<211> LENGTH: 112 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 72 Asp Ile Val Met
Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Pro
Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Phe His Ser 20 25 30
Lys Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35
40 45 Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val
Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
Phe Cys Ser Gln Ser 85 90 95 Ala His Val Pro Trp Thr Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> SEQ ID NO 73
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 73 atggacatgc
gcgtgcccgc ccagctgctg ggcctgctga tgctgtgggt gtccggctcc 60
tccggcgacg tggtgatgac ccagtccccc ctgtccctgt ccgtgtcccc cggcgagccc
120 gcctccatct cctgccgctc ctcccagtcc ctgttccact ccaagggcaa
cacctacctg 180 cactggtacc tgcagaagcc cggccagtcc cccaagctgc
tgatcaaccg cgtgtccaac 240
cgcttctccg gcgtgcccga ccgcttctcc ggctccggct ccggcaccga cttcaccctg
300 aagatctccc gcgtggaggc cgaggacgtg ggcgtgtact tctgctccca
gtccgcccac 360 gtgccctgga ccttcggcgg cggcaccaag gtggagatca ag 402
<210> SEQ ID NO 74 <211> LENGTH: 402 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 74
atggacatgc gcgtgcccgc ccagctgctg ggcctgctga tgctgtgggt gtccggctcc
60 tccggcgaca tcgtgatgac ccagtccccc ctgtccctgt ccgtgtcccc
cggcgagccc 120 gcctccatct cctgccgctc ctcccagtcc ctgttccact
ccaagggcaa cacctacctg 180 cactggtacc tgcagaagcc cggccagtcc
cccaagctgc tgatctaccg cgtgtccaac 240 cgcttctccg gcgtgcccga
ccgcttctcc ggctccggct ccggcaccga cttcaccctg 300 aagatctccc
gcgtggaggc cgaggacgtg ggcgtgtact actgctccca gtccgcccac 360
gtgccctgga ccttcggcgg cggcaccaag gtggagatca ag 402 <210> SEQ
ID NO 75 <211> LENGTH: 402 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 75 atggacatgc
gcgtgcccgc ccagctgctg ggcctgctga tgctgtgggt gtccggctcc 60
tccggcgacg tggtgatgac ccagtccccc ctgtccctgt ccgtgtcccc cggcgagccc
120 gcctccatct cctgccgctc ctcccagtcc ctgttccact ccaagggcaa
cacctacctg 180 cactggtacc tgcagaagcc cggccagtcc ccccagctgc
tgatcaaccg cgtgtccaac 240 cgcttctccg gcgtgcccga ccgcttctcc
ggctccggct ccggcaccga cttcaccctg 300 aagatctccc gcgtggaggc
cgaggacgtg ggcgtgtact tctgctccca gtccgcccac 360 gtgccctgga
ccttcggcgg cggcaccaag gtggagatca ag 402 <210> SEQ ID NO 76
<211> LENGTH: 402 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 76 atggacatgc
gcgtgcccgc ccagctgctg ggcctgctga tgctgtgggt gtccggctcc 60
tccggcgaca tcgtgatgac ccagtccccc ctgtccctgt ccgtgtcccc cggcgagccc
120 gcctccatct cctgccgctc ctcccagtcc ctgttccact ccaagggcaa
cacctacctg 180 cactggtacc tgcagaagcc cggccagtcc ccccagctgc
tgatctaccg cgtgtccaac 240 cgcttctccg gcgtgcccga ccgcttctcc
ggctccggct ccggcaccga cttcaccctg 300 aagatctccc gcgtggaggc
cgaggacgtg ggcgtgtact actgctccca gtccgcccac 360 gtgccctgga
ccttcggcgg cggcaccaag gtggagatca ag 402 <210> SEQ ID NO 77
<211> LENGTH: 321 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 77 actgtggctg
caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 60
actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg
120 aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga
gcaggacagc 180 aaggacagca cctacagcct cagcagcacc ctgacgctga
gcaaagcaga ctacgagaaa 240 cacaaagtct acgcctgcga agtcacccat
cagggcctga gctcgcccgt cacaaagagc 300 ttcaacaggg gagagtgtta g 321
<210> SEQ ID NO 78 <211> LENGTH: 35 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 78
Glu Gln Val Thr Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala 1 5
10 15 Val Ala Gln Lys Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala
Thr 20 25 30 Gly Phe Val 35 <210> SEQ ID NO 79 <211>
LENGTH: 28 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 79 Lys Glu Gln Val Thr Asn Val
Gly Gly Ala Val Val Thr Gly Val Thr 1 5 10 15 Ala Val Ala Gln Lys
Thr Val Glu Gly Ala Gly Ser 20 25 <210> SEQ ID NO 80
<211> LENGTH: 405 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 80 atgggatgga
gctgggtctt tatcttcctc ctgtcaggaa ctgcaggtgt ccattgccag 60
gtccagctgc agcagtctgg acctgagctg gtgaagcctg ggacttcagt gaagatatcc
120 tgcaaggctt ctggctacag cttcacaagc tactatatac actgggtgaa
gcagagtcct 180 ggacagggac ttgagtggat tggatggatt tatcctggaa
gtggtaatac taagtacagt 240 gagaagttca agggcaaggc cacactgact
gcagacacat cctccagcac agcctacatg 300 cagctcagca gcctgacatc
tgaggactct gcagtctatt tctgtgcaag agatggttgc 360 tacgggtttg
cttactgggg ccaagggact ctggtcactg tctct 405 <210> SEQ ID NO 81
<211> LENGTH: 135 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 81 Met Gly Trp Ser
Trp Val Phe Ile Phe Leu Leu Ser Gly Thr Ala Gly 1 5 10 15 Val His
Cys Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 20 25 30
Pro Gly Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 35
40 45 Thr Ser Tyr Tyr Ile His Trp Val Lys Gln Ser Pro Gly Gln Gly
Leu 50 55 60 Glu Trp Ile Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr
Lys Tyr Ser 65 70 75 80 Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala
Asp Thr Ser Ser Ser 85 90 95 Thr Ala Tyr Met Gln Leu Ser Ser Leu
Thr Ser Glu Asp Ser Ala Val 100 105 110 Tyr Phe Cys Ala Arg Asp Gly
Cys Tyr Gly Phe Ala Tyr Trp Gly Gln 115 120 125 Gly Thr Leu Val Thr
Val Ser 130 135 <210> SEQ ID NO 82 <211> LENGTH: 393
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 82 atggagacag acacactcct gttatgggtg
ctgctgctct gggttccagg ctccactggt 60 gacattgtgc tgacccaatc
tccagcttct ttggctgtgt ctctagggca gagggccacc 120 atctcctgca
aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac 180
caacagaaac caggacagcc acccaaattc ctcatctgtg ctgcatccaa tctagaatct
240 gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct
caacatccat 300 cctgtggagg aggaggatgc tgcaacctat tactgtcagc
aaagtaatga ggatccattc 360 acgttcggct cggggacaaa gttggaaata aaa 393
<210> SEQ ID NO 83 <211> LENGTH: 131 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 83
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5
10 15 Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu
Ala 20 25 30 Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala
Ser Gln Ser 35 40 45 Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn Trp
Tyr Gln Gln Lys Pro 50 55 60 Gly Gln Pro Pro Lys Phe Leu Ile Cys
Ala Ala Ser Asn Leu Glu Ser 65 70 75 80 Gly Ile Pro Ala Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Asn Ile His Pro
Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 100 105 110
Gln Gln Ser Asn Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 115
120 125 Glu Ile Lys 130 <210> SEQ ID NO 84 <211>
LENGTH: 345 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 84 gtccagctgc agcagtctgg
acctgagctg gtgaagcctg ggacttcagt gaagatatcc 60 tgcaaggctt
ctggctacag cttcacaagc tactatatac actgggtgaa gcagagtcct 120
ggacagggac ttgagtggat tggatggatt tatcctggaa gtggtaatac taagtacagt
180 gagaagttca agggcaaggc cacactgact gcagacacat cctccagcac
agcctacatg 240 cagctcagca gcctgacatc tgaggactct gcagtctatt
tctgtgcaag agatggttgc 300 tacgggtttg cttactgggg ccaagggact
ctggtcactg tctct 345 <210> SEQ ID NO 85 <211> LENGTH:
115 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 85 Val Gln Leu Gln Gln Ser Gly Pro Glu Leu
Val Lys Pro Gly Thr Ser 1 5 10 15 Val Lys Ile Ser Cys Lys Ala Ser
Gly Tyr Ser Phe Thr Ser Tyr Tyr 20 25 30 Ile His Trp Val Lys Gln
Ser Pro Gly Gln Gly Leu Glu Trp Ile Gly 35 40 45 Trp Ile Tyr Pro
Gly Ser Gly Asn Thr Lys Tyr Ser Glu Lys Phe Lys 50 55 60 Gly Lys
Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr Met 65 70 75 80
Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 85
90 95 Arg Asp Gly Cys Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu
Val 100 105 110 Thr Val Ser 115 <210> SEQ ID NO 86
<211> LENGTH: 333 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 86 gacattgtgc
tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc 60
atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac
120 caacagaaac caggacagcc acccaaattc ctcatctgtg ctgcatccaa
tctagaatct 180 gggatcccag ccaggtttag tggcagtggg tctgggacag
acttcaccct caacatccat 240 cctgtggagg aggaggatgc tgcaacctat
tactgtcagc aaagtaatga ggatccattc 300 acgttcggct cggggacaaa
gttggaaata aaa 333 <210> SEQ ID NO 87 <211> LENGTH: 111
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 87 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Met Asn
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 35 40 45 Lys Phe Leu Ile
Cys Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 85
90 95 Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105 110 <210> SEQ ID NO 88 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 88 Ser Tyr Tyr Ile His 1 5 <210> SEQ ID
NO 89 <211> LENGTH: 17 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 89 Trp Ile Tyr
Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu Lys Phe Lys 1 5 10 15 Gly
<210> SEQ ID NO 90 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 90
Asp Gly Cys Tyr Gly Phe Ala Tyr 1 5 <210> SEQ ID NO 91
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 91 Lys Ala Ser Gln
Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 1 5 10 15 <210>
SEQ ID NO 92 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 92
Ala Ala Ser Asn Leu Glu Ser 1 5 <210> SEQ ID NO 93
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 93 Gln Gln Ser Asn
Glu Asp Pro Phe Thr 1 5 <210> SEQ ID NO 94 <211>
LENGTH: 351 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 94 caggtgcagc tggtgcagtc
cggcgccgag ctgaagaagc ccggcgcctc cgtgaaggtg 60 tcctgcaagg
cctccggcta ctccttcacc tcctactaca tccactgggt gaagcaggcc 120
cccggccagg gcctggagtg gatcggctgg atctaccccg gctccggcaa caccaagtac
180 tccgagaagt tcaagggccg cgccaccctg accgccgaca cctccacctc
caccgcctac 240 atggagctgc gctccctgcg ctccgacgac accgccgtgt
acttctgcgc ccgcgacggc 300 tgctacggct tcgcctactg gggccagggc
accctggtga ccgtgtcctc a 351 <210> SEQ ID NO 95 <211>
LENGTH: 117 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 95 Gln Val Gln Leu Val Gln Ser
Gly Ala Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser
Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Tyr Ile His
Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly
Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu Lys Phe 50 55
60 Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr
Phe Cys 85 90 95 Ala Arg Asp Gly Cys Tyr Gly Phe Ala Tyr Trp Gly
Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115
<210> SEQ ID NO 96 <211> LENGTH: 351 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 96
caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgcctc cgtgaaggtg
60 tcctgcaagg cctccggcta ctccttcacc tcctactaca tccactgggt
gcgccaggcc 120 cccggccagg gcctggagtg gatcggctgg atctaccccg
gctccggcaa caccaagtac 180 tccgagaagt tcaagggccg cgccaccctg
accgccgaca cctccacctc caccgcctac 240 atggagctgc gctccctgcg
ctccgacgac accgccgtgt acttctgcgc ccgcgacggc 300 tgctacggct
tcgcctactg gggccagggc accctggtga ccgtgtcctc a 351 <210> SEQ
ID NO 97 <211> LENGTH: 117 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 97 Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25
30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45 Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu
Lys Phe 50 55 60 Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Thr
Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Asp Gly Cys Tyr Gly Phe
Ala Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115
<210> SEQ ID NO 98 <211> LENGTH: 351 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE: 98
caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgcctc cgtgaaggtg
60 tcctgcaagg cctccggcta caccttcacc tcctactaca tccactgggt
gcgccaggcc 120 cccggccagg gcctggagtg gatgggctgg atctaccccg
gctccggcaa caccaagtac 180 tccgagaagt tcaagggccg cgccaccatg
accgccgaca cctccacctc caccgcctac 240 atggagctgc gctccctgcg
ctccgacgac accgccgtgt actactgcgc ccgcgacggc 300 tgctacggct
tcgcctactg gggccagggc accctggtga ccgtgtcctc a 351 <210> SEQ
ID NO 99 <211> LENGTH: 117 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthesized <400> SEQUENCE: 99 Gln Val Gln
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25
30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45 Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu
Lys Phe 50 55 60 Lys Gly Arg Ala Thr Met Thr Ala Asp Thr Ser Thr
Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Cys Tyr Gly Phe
Ala Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115
<210> SEQ ID NO 100 <211> LENGTH: 351 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
100 caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgcctc
cgtgaaggtg 60 tcctgcaagg cctccggcta ctccttcacc tcctactaca
tccactgggt gcgccaggcc 120 cccggccagg gcctggagtg gatcggctgg
atctaccccg gctccggcaa caccaagtac 180 tccgagaagt tcaagggccg
cgccaccctg accgccgaca cctccacctc caccgcctac 240 atggagctgc
gctccctgcg ctccgacgac accgccgtgt acttctgcgc ccgcgacggc 300
tcctacggct tcgcctactg gggccagggc accctggtga ccgtgtcctc a 351
<210> SEQ ID NO 101 <211> LENGTH: 117 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
101 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr
Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Ile 35 40 45 Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr
Lys Tyr Ser Glu Lys Phe 50 55 60 Lys Gly Arg Ala Thr Leu Thr Ala
Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu
Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Asp Gly
Ser Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr
Val Ser Ser 115 <210> SEQ ID NO 102 <211> LENGTH: 351
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 102 caggtgcagc tggtgcagtc cggcgccgag
gtgaagaagc ccggcgcctc cgtgaaggtg 60 tcctgcaagg cctccggcta
caccttcacc tcctactaca tccactgggt gcgccaggcc 120 cccggccagg
gcctggagtg gatgggctgg atctaccccg gctccggcaa caccaagtac 180
tccgagaagt tcaagggccg cgccaccatg accgccgaca cctccacctc caccgcctac
240 atggagctgc gctccctgcg ctccgacgac accgccgtgt actactgcgc
ccgcgacggc 300 tcctacggct tcgcctactg gggccagggc accctggtga
ccgtgtcctc a 351 <210> SEQ ID NO 103 <211> LENGTH: 117
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 103 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr
Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu Lys Phe 50 55 60 Lys Gly
Arg Ala Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr
Leu 100 105 110 Val Thr Val Ser Ser 115 <210> SEQ ID NO 104
<211> LENGTH: 57 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 104 atggagttcg
gcctgtcctg gctgttcctg gtggccatcc tgaagggcgt gcagtgc 57 <210>
SEQ ID NO 105 <211> LENGTH: 19 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
105 Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly
1 5 10 15 Val Gln Cys
<210> SEQ ID NO 106 <211> LENGTH: 57 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
106 atggactgga cctggagcat ccttttcttg gtggcagcag caacaggtgc ccactcc
57 <210> SEQ ID NO 107 <211> LENGTH: 19 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <400>
SEQUENCE: 107 Met Asp Trp Thr Trp Ser Ile Leu Phe Leu Val Ala Ala
Ala Thr Gly 1 5 10 15 Ala His Ser <210> SEQ ID NO 108
<211> LENGTH: 333 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 108 gacatccagc
tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc 60
atcacctgca aggcctccca gtccgtggac tacgacggcg actcctacat gaactggtac
120 cagcagaagc ccggcaaggc ccccaagttc ctgatctgcg ccgcctccaa
cctggagtcc 180 ggcgtgccct cccgcttctc cggctccggc tccggcaccg
acttcaccct gaccatctcc 240 tccctgcagc ccgaggacgc cgccacctac
tactgccagc agtccaacga ggaccccttc 300 accttcggcc agggcaccaa
gctggagatc aag 333 <210> SEQ ID NO 109 <211> LENGTH:
111 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 109 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Met Asn
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Phe Leu Ile
Cys Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80
Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 85
90 95 Glu Asp Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110 <210> SEQ ID NO 110 <211> LENGTH: 333
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 110 gacatccagc tgacccagtc cccctcctcc
ctgtccgcct ccgtgggcga ccgcgtgacc 60 atcacctgca aggcctccca
gtccgtggac tacgacggcg actcctacat gaactggtac 120 cagcagaagc
ccggcaaggc ccccaagttc ctgatctacg ccgcctccaa cctggagtcc 180
ggcgtgccct cccgcttctc cggctccggc tccggcaccg acttcaccct gaccatctcc
240 tccctgcagc ccgaggacgc cgccacctac tactgccagc agtccaacga
ggaccccttc 300 accttcggcc agggcaccaa gctggagatc aag 333 <210>
SEQ ID NO 111 <211> LENGTH: 111 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
111 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
Tyr Asp 20 25 30 Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro
Gly Lys Ala Pro 35 40 45 Lys Phe Leu Ile Tyr Ala Ala Ser Asn Leu
Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp
Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 85 90 95 Glu Asp Pro Phe
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210>
SEQ ID NO 112 <211> LENGTH: 333 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
112 gacatccagc tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga
ccgcgtgacc 60 atcacctgca aggcctccca gtccgtggac tacgacggcg
actcctacat gaactggtac 120 cagcagaagc ccggcaaggc ccccaagttc
ctgatctgcg ccgcctccaa cctggagtcc 180 ggcgtgccct cccgcttctc
cggctccggc tccggcaccg acttcaccct gaccatctcc 240 tccctgcagc
ccgaggactt cgccacctac tactgccagc agtccaacga ggaccccttc 300
accttcggcc agggcaccaa gctggagatc aag 333 <210> SEQ ID NO 113
<211> LENGTH: 111 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 113 Asp Ile Gln Leu
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg
Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35
40 45 Lys Phe Leu Ile Cys Ala Ala Ser Asn Leu Glu Ser Gly Val Pro
Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
Cys Gln Gln Ser Asn 85 90 95 Glu Asp Pro Phe Thr Phe Gly Gln Gly
Thr Lys Leu Glu Ile Lys 100 105 110 <210> SEQ ID NO 114
<211> LENGTH: 333 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 114 gacatccagc
tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc 60
atcacctgca aggcctccca gtccgtggac tacgacggcg actcctacat gaactggtac
120 cagcagaagc ccggcaaggc ccccaagttc ctgatctacg ccgcctccaa
cctggagtcc 180 ggcgtgccct cccgcttctc cggctccggc tccggcaccg
acttcaccct gaccatctcc 240 tccctgcagc ccgaggactt cgccacctac
tactgccagc agtccaacga ggaccccttc 300 accttcggcc agggcaccaa
gctggagatc aag 333 <210> SEQ ID NO 115 <211> LENGTH:
111 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 115 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Met Asn
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Phe Leu Ile
Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 85
90 95 Glu Asp Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110 <210> SEQ ID NO 116 <211> LENGTH: 66
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 116 atggacatgc gcgtgcccgc ccagctgctg
ggcctgctga tgctgtgggt gtccggctcc 60
tccggc 66 <210> SEQ ID NO 117 <211> LENGTH: 117
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 117 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Phe 20 25 30 Gly Ile Ser Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser
Pro Tyr Asn Gly Asp Thr Asn Tyr Ala Gln Asn Leu 50 55 60 Gln Gly
Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Asp Arg Gly Ser Met Ser Asp Tyr Trp Gly Gln Gly Thr
Leu 100 105 110 Val Thr Val Ser Ser 115 <210> SEQ ID NO 118
<211> LENGTH: 107 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 118 Asp Ile Gln Leu
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg
Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35
40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser
Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp
Tyr Asn Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu
Ile Lys 100 105 <210> SEQ ID NO 119 <211> LENGTH: 117
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 119 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr
Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu Lys Phe 50 55 60 Lys Gly
Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Asp Gly Cys Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr
Leu 100 105 110 Val Thr Val Ser Ser 115 <210> SEQ ID NO 120
<211> LENGTH: 111 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 120 Asp Ile Gln Leu
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg
Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35
40 45 Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro
Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
Cys Gln Gln Ser Asn 85 90 95 Glu Asp Pro Phe Thr Phe Gly Gln Gly
Thr Lys Leu Glu Ile Lys 100 105 110 <210> SEQ ID NO 121
<211> LENGTH: 117 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (11)..(11) <223> OTHER
INFORMATION: Xaa = V or L <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (28)..(28) <223>
OTHER INFORMATION: Xaa = S or T <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (38)..(38) <223>
OTHER INFORMATION: Xaa = R or K <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (48)..(48) <223>
OTHER INFORMATION: Xaa = M or I <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (68)..(68) <223>
OTHER INFORMATION: Xaa = V or A <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (70)..(70) <223>
OTHER INFORMATION: Xaa = M or L <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (72)..(72) <223>
OTHER INFORMATION: Xaa = T or A <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (95)..(95) <223>
OTHER INFORMATION: Xaa = Y or F <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (101)..(101) <223>
OTHER INFORMATION: Xaa = C or S <400> SEQUENCE: 121 Gln Val
Gln Leu Val Gln Ser Gly Ala Glu Xaa Lys Lys Pro Gly Ala 1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Xaa Phe Thr Ser Tyr 20
25 30 Tyr Ile His Trp Val Xaa Gln Ala Pro Gly Gln Gly Leu Glu Trp
Xaa 35 40 45 Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Ser
Glu Lys Phe 50 55 60 Lys Gly Arg Xaa Thr Xaa Thr Xaa Asp Thr Ser
Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp
Asp Thr Ala Val Tyr Xaa Cys 85 90 95 Ala Arg Asp Gly Xaa Tyr Gly
Phe Ala Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser
115 <210> SEQ ID NO 122 <211> LENGTH: 111 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthesized <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(50)..(50) <223> OTHER INFORMATION: Xaa = L or F <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(53)..(53) <223> OTHER INFORMATION: Xaa = Y or C <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(87)..(87) <223> OTHER INFORMATION: Xaa = F or A <400>
SEQUENCE: 122 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala
Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln
Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Met Asn Trp Tyr Gln
Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Xaa Leu Ile Xaa Ala Ala
Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln
Pro Glu Asp Xaa Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 85 90 95 Glu
Asp Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110
<210> SEQ ID NO 123 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (3)..(3) <223> OTHER INFORMATION: Xaa = C or M or S
or T <400> SEQUENCE: 123 Asp Gly Xaa Tyr Gly Phe Ala Tyr 1 5
<210> SEQ ID NO 124 <211> LENGTH: 218 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
124 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
Tyr Asp 20 25 30 Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro
Gly Lys Ala Pro 35 40 45 Lys Phe Leu Ile Cys Ala Ala Ser Asn Leu
Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp
Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 85 90 95 Glu Asp Pro Phe
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130
135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser
Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val
Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn
Arg Gly Glu Cys 210 215 <210> SEQ ID NO 125 <211>
LENGTH: 217 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 125 Asp Ile Gln Leu Thr Gln Ser
Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile
Thr Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser
Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys
Phe Leu Ile Cys Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55
60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65 70 75 80 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
Ser Asn 85 90 95 Glu Asp Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu
Glu Ile Lys Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro
Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val
Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln
Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185
190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val
195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210>
SEQ ID NO 126 <211> LENGTH: 447 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
126 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr
Lys Tyr Ser Glu Lys Phe 50 55 60 Lys Gly Arg Ala Thr Met Thr Ala
Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu
Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly
Cys Tyr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 130
135 140 Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
Ser 145 150 155 160 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
Val Leu Gln Ser 165 170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
Thr Val Pro Ser Ser Ser 180 185 190 Leu Gly Thr Gln Thr Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Arg
Val Glu Pro Lys Ser Cys Asp Lys Thr His 210 215 220 Thr Cys Pro Pro
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 225 230 235 240 Phe
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250
255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
260 265 270 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
Val Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala
Leu Pro Ala Pro Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375
380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser Pro Gly Lys 435 440 445 <210> SEQ ID NO 127
<211> LENGTH: 447 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 127 Gln Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val
Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35
40 45 Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Ser Glu Lys
Phe 50 55 60 Lys Gly Arg Ala Thr Met Thr Ala Asp Thr Ser Thr Ser
Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Cys Tyr Gly Phe Ala
Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser Ala Ser
Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125 Ala Pro Ser Ser Lys
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 145 150 155 160
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
165 170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
Ser Ser 180 185 190 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
Lys Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Arg Val Glu Pro Lys
Ser Cys Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280
285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Glu Glu Met Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405
410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 435 440 445 <210> SEQ ID NO 128 <211> LENGTH:
326 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 128 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala
Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser
Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 65 70 75 80
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85
90 95 Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala
Pro 100 105 110 Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
Pro Lys Asp 115 120 125 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val Val Val Asp 130 135 140 Val Ser His Glu Asp Pro Glu Val Gln
Phe Asn Trp Tyr Val Asp Gly 145 150 155 160 Val Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 165 170 175 Ser Thr Phe Arg
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 180 185 190 Leu Asn
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 195 200 205
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 210
215 220 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
Asn 225 230 235 240 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile 245 250 255 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr 260 265 270 Thr Pro Pro Met Leu Asp Ser Asp
Gly Ser Phe Phe Leu Tyr Ser Lys 275 280 285 Leu Thr Val Asp Lys Ser
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 290 295 300 Ser Val Met His
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 305 310 315 320 Ser
Leu Ser Pro Gly Lys 325 <210> SEQ ID NO 129 <211>
LENGTH: 330 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 129 Ala Ser Thr Lys Gly Pro Ser
Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55
60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val
Asp Lys 85 90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile
Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser
His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185
190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala
Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310
315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210>
SEQ ID NO 130 <211> LENGTH: 113 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
130 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Glu Pro Gly Gly
1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp Phe Glu
Lys Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Gln Trp Val 35 40 45 Ala Arg Ile Lys Ser Thr Ala Asp Gly Gly
Thr Thr Ser Tyr Ala Ala 50 55 60 Pro Val Glu Gly Arg Phe Ile Ile
Ser Arg Asp Asp Ser Arg Asn Met 65 70 75 80 Leu Tyr Leu Gln Met Asn
Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Ser
Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser
<210> SEQ ID NO 131 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
131 Lys Ala Trp Met Ser 1 5 <210> SEQ ID NO 132 <211>
LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
132 Arg Ile Lys Ser Thr Ala Asp Gly Gly Thr Thr Ser Tyr Ala Ala Pro
1 5 10 15 Val Glu Gly <210> SEQ ID NO 133 <400>
SEQUENCE: 133 000 <210> SEQ ID NO 134 <211> LENGTH: 108
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 134 Gln Ser Val Leu Thr Gln Pro Pro Ser Val
Ser Val Ser Pro Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Ser Gly
Glu Ala Leu Pro Met Gln Phe Ala 20 25 30 His Trp Tyr Gln Gln Arg
Pro Gly Lys Ala Pro Val Ile Val Val Tyr 35 40 45 Lys Asp Ser Glu
Arg Pro Ser Gly Val Pro Glu Arg Phe Ser Gly Ser 50 55 60 Ser Ser
Gly Thr Thr Ala Thr Leu Thr Ile Thr Gly Val Gln Ala Glu 65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Pro Asp Ser Thr Asn Thr Tyr 85
90 95 Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105
<210> SEQ ID NO 135 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
135 Ser Gly Glu Ala Leu Pro Met Gln Phe Ala His 1 5 10 <210>
SEQ ID NO 136 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
136 Lys Asp Ser Glu Arg Pro Ser 1 5 <210> SEQ ID NO 137
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 137 Gln Ser Pro Asp
Ser Thr Asn Thr Tyr Glu Val 1 5 10 <210> SEQ ID NO 138
<211> LENGTH: 124 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 138 Glu Val Gln Leu
Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val
Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 35
40 45 Gly Trp Ile Asn Ala Gly Asn Gly Lys Arg Lys Tyr Ser Gln Lys
Phe 50 55 60 Gln Asp Arg Val Thr Ile Asn Arg Asp Thr Ser Ala Ser
Thr Ile Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Gly Ser Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Glu Asp His Ala Gly Ser
Gly Ser Tyr Leu Ser Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Leu
Val Thr Val Ser Ser 115 120 <210> SEQ ID NO 139 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 139 Asn Tyr Ala Met His 1 5
<210> SEQ ID NO 140 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
140 Trp Ile Asn Ala Gly Asn Gly Lys Arg Lys Tyr Ser Gln Lys Phe Gln
1 5 10 15 Asp <210> SEQ ID NO 141 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 141 Glu Glu Asp His Ala Gly Ser Gly Ser Tyr
Leu Ser Met Asp Val 1 5 10 15 <210> SEQ ID NO 142 <211>
LENGTH: 113 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 142 Asp Val Val Met Thr Gln Ser
Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile
Asn Cys Lys Ser Ser Gln Asn Val Leu Tyr Ser 20 25 30 Ser Asn Asn
Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly His 35 40 45 Pro
Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55
60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80 Ile Thr Ser Leu Gln Thr Glu Asp Val Ala Val Tyr Tyr Cys
Gln Gln 85 90 95 Tyr Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr
Lys Val Glu Ile 100 105 110 Lys <210> SEQ ID NO 143
<211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 143 Lys Ser Ser Gln
Asn Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 1 5 10 15 Ala
<210> SEQ ID NO 144 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthesized <400> SEQUENCE:
144 Trp Ala Ser Thr Arg Glu Ser 1 5 <210> SEQ ID NO 145
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 145 Gln Gln Tyr Tyr
Ser Ser Pro Leu Thr 1 5 <210> SEQ ID NO 146 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial
sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthesized <400> SEQUENCE: 146 Asn Tyr Gly Met Ser 1 5
<210> SEQ ID NO 147 <211> LENGTH: 17
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 147 Ser Ile Ser Ser Gly Gly Gly Ser Thr Tyr
Tyr Pro Asp Asn Val Lys 1 5 10 15 Gly <210> SEQ ID NO 148
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 148 Gly Gly Ala Gly
Ile Asp Tyr 1 5 <210> SEQ ID NO 149 <211> LENGTH: 17
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 149 Lys Ser Ile Gln Thr Leu Leu Tyr Ser Ser
Asn Gln Lys Asn Tyr Leu 1 5 10 15 Ala <210> SEQ ID NO 150
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Artificial sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthesized <400> SEQUENCE: 150 Trp Ala Ser Ile
Arg Lys Ser 1 5 <210> SEQ ID NO 151 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Artificial sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthesized
<400> SEQUENCE: 151 Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr 1
5
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