U.S. patent application number 16/209239 was filed with the patent office on 2019-03-21 for variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods. The applicant listed for this patent is AMGEN INC.. Invention is credited to Edward J. Belouski, Randy Ira Hecht, Randal R. Ketchem, Mark Leo Michaels, Jason Charles O'Neill, Jeonghoon Sun.
Application Number | 20190085054 16/209239 |
Document ID | / |
Family ID | 50473803 |
Filed Date | 2019-03-21 |
United States Patent Application | 20190085054 |
Kind Code | A1 |
Sun; Jeonghoon ; et al. | March 21, 2019 |
There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
Inventors: | Sun; Jeonghoon; (Poway, CA) ; O'Neill; Jason Charles; (Brier, WA) ; Ketchem; Randal R.; (Snohomish, WA) ; Hecht; Randy Ira; (Raleigh, NC) ; Belouski; Edward J.; (Thousand Oaks, CA) ; Michaels; Mark Leo; (Encino, CA) | ||||||||||
Applicant: |
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Family ID: | 50473803 | ||||||||||
Appl. No.: | 16/209239 | ||||||||||
Filed: | December 4, 2018 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
14775482 | Sep 11, 2015 | 10189890 | ||
PCT/US14/26811 | Mar 13, 2014 | |||
16209239 | ||||
61782613 | Mar 14, 2013 | |||
61798160 | Mar 15, 2013 | |||
61802988 | Mar 18, 2013 | |||
61940673 | Feb 17, 2014 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | A61P 1/00 20180101; A61P 9/04 20180101; C12N 9/6489 20130101; A61P 13/00 20180101; A61P 29/00 20180101; A61P 17/06 20180101; A61P 19/10 20180101; A61P 25/28 20180101; A61P 43/00 20180101; A61P 25/00 20180101; A61K 38/00 20130101; A61P 1/04 20180101; A61P 11/00 20180101; A61P 11/08 20180101; A61P 17/02 20180101; A61P 1/02 20180101; A61P 1/16 20180101; A61P 9/00 20180101; A61P 27/02 20180101; C07K 14/8146 20130101; A61P 31/12 20180101; A61P 11/02 20180101; A61P 37/06 20180101; A61P 21/04 20180101; A61P 31/00 20180101; A61P 19/00 20180101; A61P 11/06 20180101; A61P 17/04 20180101; A61P 19/08 20180101; A61P 33/00 20180101; A61P 37/08 20180101; A61P 21/00 20180101; A61P 37/02 20180101; A61P 19/02 20180101; Y02A 50/30 20180101; A61P 35/00 20180101; A61P 1/18 20180101; A61P 9/10 20180101; A61P 15/14 20180101; A61P 37/00 20180101 |
International Class: | C07K 14/81 20060101 C07K014/81; C12N 9/64 20060101 C12N009/64 |
Sequence CWU 1
1
991633DNAHomo sapiens 1atgacccctt ggctcgggct catcgtgctc ctgggcagct
ggagcctggg ggactggggc 60gccgaggcgt gcacatgctc gcccagccac ccccaggacg
ccttctgcaa ctccgacatc 120gtgatccggg ccaaggtggt ggggaagaag
ctggtaaagg aggggccctt cggcacgctg 180gtctacacca tcaagcagat
gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag 240tacatccaca
cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac
300cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct
gtgcaacttc 360gtggagaggt gggaccagct caccctctcc cagcgcaagg
ggctgaacta tcggtatcac 420ctgggttgta actgcaagat caagtcctgc
tactacctgc cttgctttgt gacttccaag 480aacgagtgtc tctggaccga
catgctctcc aatttcggtt accctggcta ccagtccaaa 540cactacgcct
gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc
600ccggataaaa gcatcatcaa tgccacagac ccc 6332211PRTHomo sapiens 2Met
Thr Pro Trp Leu Gly Leu Ile Val Leu Leu Gly Ser Trp Ser Leu 1 5 10
15 Gly Asp Trp Gly Ala Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln
20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val
Val Gly 35 40 45 Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu
Val Tyr Thr Ile 50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr
Lys Met Pro His Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu
Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr
Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly
Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser
Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140
Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145
150 155 160 Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr
Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys
Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp
Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp Pro 210
3211PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid from a
heterologous signal peptideMOD_RES(2)..(2)Thr or any amino acid
from a heterologous signal peptideMOD_RES(3)..(3)Pro or any amino
acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or any
amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or
any amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(7)..(7)Leu or any amino acid from a heterologous
signal peptideMOD_RES(8)..(8)Ile or any amino acid from a
heterologous signal peptideMOD_RES(9)..(9)Val or any amino acid
from a heterologous signal peptideMOD_RES(10)..(11)Leu or any amino
acid from a heterologous signal peptideMOD_RES(12)..(12)Gly or any
amino acid from a heterologous signal peptideMOD_RES(13)..(13)Ser
or any amino acid from a heterologous signal
peptideMOD_RES(14)..(14)Trp or any amino acid from a heterologous
signal peptideMOD_RES(15)..(15)Ser or any amino acid from a
heterologous signal peptideMOD_RES(16)..(16)Leu or any amino acid
from a heterologous signal peptideMOD_RES(17)..(17)Gly or any amino
acid from a heterologous signal peptideMOD_RES(18)..(18)Asp or any
amino acid from a heterologous signal peptideMOD_RES(19)..(19)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(20)..(20)Gly or any amino acid from a heterologous
signal peptideMOD_RES(21)..(21)Ala or any amino acid from a
heterologous signal peptideMOD_RES(22)..(22)Glu or any amino acid
from a heterologous signal peptideMOD_RES(23)..(23)Ala or any amino
acid from a heterologous signal peptideMOD_RES(45)..(45)Lys, Glu,
Asn or SerMOD_RES(47)..(47)Val or ThrMOD_RES(49)..(49)Lys, Glu, Asn
or SerMOD_RES(50)..(50)Lys or AsnMOD_RES(51)..(51)Leu, Asn or
ThrMOD_RES(52)..(52)Val or ThrMOD_RES(53)..(53)Lys or
ThrMOD_RES(56)..(56)Pro or AsnMOD_RES(57)..(57)Phe or
AsnMOD_RES(58)..(58)Gly or ThrMOD_RES(63)..(63)Thr, Glu or
AsnMOD_RES(65)..(65)Lys, Thr or AsnMOD_RES(67)..(67)Met or
ThrMOD_RES(68)..(68)Lys or SerMOD_RES(74)..(74)Thr or
GluMOD_RES(75)..(75)Lys or AsnMOD_RES(77)..(77)Pro or
ThrMOD_RES(78)..(78)His, Asp, Glu or AsnMOD_RES(80)..(80)Gln, Glu
or ThrMOD_RES(94)..(94)Lys or AsnMOD_RES(96)..(96)Glu, Thr or
AsnMOD_RES(97)..(97)Val or AsnMOD_RES(98)..(98)Asn or
ThrMOD_RES(99)..(99)Lys or ThrMOD_RES(110)..(110)Asp or
AsnMOD_RES(112)..(112)Lys or ThrMOD_RES(126)..(126)Gln or
AsnMOD_RES(133)..(133)Lys or SerMOD_RES(138)..(138)Arg, Asn or
ThrMOD_RES(140)..(140)His or ThrMOD_RES(158)..(158)Thr or
AsnMOD_RES(160)..(160)Lys or ThrMOD_RES(166)..(166)Thr or
AsnMOD_RES(168)..(168)Met or ThrMOD_RES(173)..(173)Gly or
ThrMOD_RES(181)..(181)His or AsnMOD_RES(183)..(183)Ala or
ThrMOD_RES(186)..(186)Arg or AsnMOD_RES(188)..(188)Lys or
ThrMOD_RES(201)..(201)Pro or AsnMOD_RES(203)..(203)Lys or
ThrMOD_RES(208)..(208)Ala, Val or Tyr 3Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Xaa Val Xaa Gly 35 40 45 Xaa
Xaa Xaa Xaa Xaa Glu Gly Xaa Xaa Xaa Thr Leu Val Tyr Xaa Ile 50 55
60 Xaa Gln Xaa Xaa Met Tyr Arg Gly Phe Xaa Xaa Met Xaa Xaa Val Xaa
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Xaa
Leu Xaa 85 90 95 Xaa Xaa Xaa Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Xaa Gly Xaa 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Xaa Leu Thr 115 120 125 Leu Ser Gln Arg Xaa Gly Leu Asn
Tyr Xaa Tyr Xaa Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Xaa Ser Xaa 145 150 155 160 Asn Glu Cys
Leu Trp Xaa Asp Xaa Leu Ser Asn Phe Xaa Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys Xaa Tyr Xaa Cys Ile Xaa Gln Xaa Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Xaa Asp Xaa Ser Ile Ile Asn Xaa
195 200 205 Thr Asp Pro 210 4211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptideMOD_RES(25)..(25)Thr, His, Lys, Pro, Arg, Ser or
TrpMOD_RES(27)..(27)Ser or AlaMOD_RES(28)..(28)Pro, Asp, Leu or
SerMOD_RES(32)..(32)Gln or AsnMOD_RES(39)..(39)Asp or
ThrMOD_RES(43)..(43)Arg, Thr, Phe, Ala or AsnMOD_RES(45)..(45)Lys,
Ile or ThrMOD_RES(46)..(46)Val or AspMOD_RES(48)..(48)Gly or
SerMOD_RES(49)..(49)Lys or SerMOD_RES(51)..(51)Leu or
ThrMOD_RES(53)..(53)Lys or ThrMOD_RES(54)..(54)Glu or
TyrMOD_RES(67)..(67)Met or AsnMOD_RES(68)..(68)Lys or
IleMOD_RES(78)..(78)His, Asp or TrpMOD_RES(202)..(202)Asp or
AsnMOD_RES(207)..(207)Asn or Ser 4Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Cys Xaa Cys Xaa Xaa Ser His Pro Xaa 20 25 30 Asp Ala Phe Cys
Asn Ser Xaa Ile Val Ile Xaa Ala Xaa Xaa Val Xaa 35 40 45 Xaa Lys
Xaa Val Xaa Xaa Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60
Lys Gln Xaa Xaa Met Tyr Arg Gly Phe Thr Lys Met Pro Xaa Val Gln 65
70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Xaa Lys Ser Ile Ile Xaa Ala
195 200 205 Thr Asp Pro 210 5211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 5Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser
Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile Val
Ile Arg Ala Glu Val Val Gly 35 40 45 Ser Lys Leu Val Lys Glu Gly
Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Lys Met
Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 65 70 75 80 Tyr Ile His
Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95 Val
Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100 105
110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr
115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly
Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe
Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met Leu
Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr Ala
Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg Gly
Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp Pro
210 6211PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid from a
heterologous signal peptideMOD_RES(2)..(2)Thr or any amino acid
from a heterologous signal peptideMOD_RES(3)..(3)Pro or any amino
acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or any
amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or
any amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(7)..(7)Leu or any amino acid from a heterologous
signal peptideMOD_RES(8)..(8)Ile or any amino acid from a
heterologous signal peptideMOD_RES(9)..(9)Val or any amino acid
from a heterologous signal peptideMOD_RES(10)..(11)Leu or any amino
acid from a heterologous signal peptideMOD_RES(12)..(12)Gly or any
amino acid from a heterologous signal peptideMOD_RES(13)..(13)Ser
or any amino acid from a heterologous signal
peptideMOD_RES(14)..(14)Trp or any amino acid from a heterologous
signal peptideMOD_RES(15)..(15)Ser or any amino acid from a
heterologous signal peptideMOD_RES(16)..(16)Leu or any amino acid
from a heterologous signal peptideMOD_RES(17)..(17)Gly or any amino
acid from a heterologous signal peptideMOD_RES(18)..(18)Asp or any
amino acid from a heterologous signal peptideMOD_RES(19)..(19)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(20)..(20)Gly or any amino acid from a heterologous
signal peptideMOD_RES(21)..(21)Ala or any amino acid from a
heterologous signal peptideMOD_RES(22)..(22)Glu or any amino acid
from a heterologous signal peptideMOD_RES(23)..(23)Ala or any amino
acid from a heterologous signal peptide 6Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala
Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Glu Val Val Gly 35 40 45
Glu Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50
55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val
Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu
Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg
Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val
Glu Arg Trp Asp Gln Leu Thr 115
120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys
Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val
Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met Leu Ser
Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr Ala Cys
Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg Gly Trp
Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp Pro 210
7211PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid from a
heterologous signal peptideMOD_RES(2)..(2)Thr or any amino acid
from a heterologous signal peptideMOD_RES(3)..(3)Pro or any amino
acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or any
amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or
any amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(7)..(7)Leu or any amino acid from a heterologous
signal peptideMOD_RES(8)..(8)Ile or any amino acid from a
heterologous signal peptideMOD_RES(9)..(9)Val or any amino acid
from a heterologous signal peptideMOD_RES(10)..(11)Leu or any amino
acid from a heterologous signal peptideMOD_RES(12)..(12)Gly or any
amino acid from a heterologous signal peptideMOD_RES(13)..(13)Ser
or any amino acid from a heterologous signal
peptideMOD_RES(14)..(14)Trp or any amino acid from a heterologous
signal peptideMOD_RES(15)..(15)Ser or any amino acid from a
heterologous signal peptideMOD_RES(16)..(16)Leu or any amino acid
from a heterologous signal peptideMOD_RES(17)..(17)Gly or any amino
acid from a heterologous signal peptideMOD_RES(18)..(18)Asp or any
amino acid from a heterologous signal peptideMOD_RES(19)..(19)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(20)..(20)Gly or any amino acid from a heterologous
signal peptideMOD_RES(21)..(21)Ala or any amino acid from a
heterologous signal peptideMOD_RES(22)..(22)Glu or any amino acid
from a heterologous signal peptideMOD_RES(23)..(23)Ala or any amino
acid from a heterologous signal peptide 7Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala
Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Glu Val Val Gly 35 40 45
Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 50
55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val
Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu
Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg
Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val
Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu
Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser
Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu
Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175
Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180
185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn
Ala 195 200 205 Thr Asp Pro 210 8211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 8Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys
Asn Ser Asp Ile Val Ile Arg Ala Glu Val Val Gly 35 40 45 Lys Lys
Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60
Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Glu 65
70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 9211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 9Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser
Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile Val
Ile Arg Ala Lys Val Val Gly 35 40 45 Lys Lys Leu Val Lys Glu Gly
Pro Phe Gly Thr Leu Val Tyr Glu Ile 50 55 60 Lys Gln Met Lys Met
Tyr Arg Gly Phe Thr Lys Met Pro Glu Val Gln 65 70 75 80 Tyr Ile His
Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95 Val
Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100 105
110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr
115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly
Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe
Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met Leu
Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr Ala
Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg Gly
Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp Pro
210 10211PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid from a
heterologous signal peptideMOD_RES(2)..(2)Thr or any amino acid
from a heterologous signal peptideMOD_RES(3)..(3)Pro or any amino
acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or any
amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or
any amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(7)..(7)Leu or any amino acid from a heterologous
signal peptideMOD_RES(8)..(8)Ile or any amino acid from a
heterologous signal peptideMOD_RES(9)..(9)Val or any amino acid
from a heterologous signal peptideMOD_RES(10)..(11)Leu or any amino
acid from a heterologous signal peptideMOD_RES(12)..(12)Gly or any
amino acid from a heterologous signal peptideMOD_RES(13)..(13)Ser
or any amino acid from a heterologous signal
peptideMOD_RES(14)..(14)Trp or any amino acid from a heterologous
signal peptideMOD_RES(15)..(15)Ser or any amino acid from a
heterologous signal peptideMOD_RES(16)..(16)Leu or any amino acid
from a heterologous signal peptideMOD_RES(17)..(17)Gly or any amino
acid from a heterologous signal peptideMOD_RES(18)..(18)Asp or any
amino acid from a heterologous signal peptideMOD_RES(19)..(19)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(20)..(20)Gly or any amino acid from a heterologous
signal peptideMOD_RES(21)..(21)Ala or any amino acid from a
heterologous signal peptideMOD_RES(22)..(22)Glu or any amino acid
from a heterologous signal peptideMOD_RES(23)..(23)Ala or any amino
acid from a heterologous signal peptide 10Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala
Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Glu Val Val Gly 35 40 45
Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 50
55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro Glu Val
Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu
Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg
Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val
Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu
Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser
Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu
Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175
Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180
185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn
Ala 195 200 205 Thr Asp Pro 210 11211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 11Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro Glu Val Glu
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser
Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser
Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200
205 Thr Asp Pro 210 12211PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or any
amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr or
any amino acid from a heterologous signal peptideMOD_RES(3)..(3)Pro
or any amino acid from a heterologous signal
peptideMOD_RES(4)..(4)Trp or any amino acid from a heterologous
signal peptideMOD_RES(5)..(5)Leu or any amino acid from a
heterologous signal peptideMOD_RES(6)..(6)Gly or any amino acid
from a heterologous signal peptideMOD_RES(7)..(7)Leu or any amino
acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or any
amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val or
any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 12Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Glu Val Val Gly 35 40 45 Lys Lys Leu Val Lys Glu
Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 50 55 60 Lys Gln Met Lys
Met Tyr Arg Gly Phe Thr Lys Met Pro Glu Val Glu 65 70 75 80 Tyr Ile
His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100
105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu
Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu
Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys
Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met
Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr
Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg
Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp
Pro 210 13211PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid
from a heterologous signal peptideMOD_RES(2)..(2)Thr or any amino
acid from a heterologous signal peptideMOD_RES(3)..(3)Pro or any
amino acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or
any amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(6)..(6)Gly or any amino acid from a heterologous
signal peptideMOD_RES(7)..(7)Leu or any amino acid from a
heterologous signal peptideMOD_RES(8)..(8)Ile or any amino acid
from a heterologous signal peptideMOD_RES(9)..(9)Val or any amino
acid from a heterologous signal peptideMOD_RES(10)..(11)Leu or any
amino acid from a heterologous signal peptideMOD_RES(12)..(12)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(13)..(13)Ser or any amino acid from a heterologous
signal peptideMOD_RES(14)..(14)Trp or any amino acid from a
heterologous signal peptideMOD_RES(15)..(15)Ser or any amino acid
from a heterologous signal peptideMOD_RES(16)..(16)Leu or any amino
acid from a heterologous signal peptideMOD_RES(17)..(17)Gly or any
amino acid from a heterologous signal peptideMOD_RES(18)..(18)Asp
or any amino acid from a heterologous signal
peptideMOD_RES(19)..(19)Trp or any amino acid from a heterologous
signal peptideMOD_RES(20)..(20)Gly or any amino acid from a
heterologous signal peptideMOD_RES(21)..(21)Ala or any amino acid
from a heterologous signal peptideMOD_RES(22)..(22)Glu or any amino
acid from a heterologous signal peptideMOD_RES(23)..(23)Ala or any
amino acid from a heterologous signal peptide 13Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp
Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40
45 Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile
50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Glu
Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly
Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly
Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe
Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly
Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys
Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn
Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170
175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys
180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile
Asn Ala 195 200 205 Thr Asp Pro 210 14211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 14Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Asp Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 15211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 15Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys Lys Thr Val Lys Glu
Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Lys
Met Tyr Arg Gly Phe Glu Lys Met Pro Asp Val Gln 65 70 75 80 Tyr Ile
His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100
105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu
Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu
Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys
Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met
Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr
Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg
Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp
Pro 210 16211PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid
from a heterologous signal peptideMOD_RES(2)..(2)Thr or any amino
acid from a heterologous signal peptideMOD_RES(3)..(3)Pro or any
amino acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or
any amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(6)..(6)Gly or any amino acid from a heterologous
signal peptideMOD_RES(7)..(7)Leu or any amino acid from a
heterologous signal peptideMOD_RES(8)..(8)Ile or any amino acid
from a heterologous signal peptideMOD_RES(9)..(9)Val or any amino
acid from a heterologous signal peptideMOD_RES(10)..(11)Leu or any
amino acid from a heterologous signal peptideMOD_RES(12)..(12)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(13)..(13)Ser or any amino acid from a heterologous
signal peptideMOD_RES(14)..(14)Trp or any amino acid from a
heterologous signal peptideMOD_RES(15)..(15)Ser or any amino acid
from a heterologous signal peptideMOD_RES(16)..(16)Leu or any amino
acid from a heterologous signal peptideMOD_RES(17)..(17)Gly or any
amino acid from a heterologous signal peptideMOD_RES(18)..(18)Asp
or any amino acid from a heterologous signal
peptideMOD_RES(19)..(19)Trp or any amino acid from a heterologous
signal peptideMOD_RES(20)..(20)Gly or any amino acid from a
heterologous signal peptideMOD_RES(21)..(21)Ala or any amino acid
from a heterologous signal peptideMOD_RES(22)..(22)Glu or any amino
acid from a heterologous signal peptideMOD_RES(23)..(23)Ala or any
amino acid from a heterologous signal peptide 16Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp
Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40
45 Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile
50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Glu
Val Glu 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly
Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly
Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe
Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly
Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys
Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn
Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170
175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys
180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile
Asn Ala 195 200 205 Thr Asp Pro 210 17211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a
heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 17Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Asp Val Glu
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 18211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 18Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Asn Val Thr Gly 35 40 45 Lys Lys Leu Val Lys Glu
Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 50 55 60 Lys Gln Met Lys
Met Tyr Arg Gly Phe Glu Lys Met Pro Glu Val Gln 65 70 75 80 Tyr Ile
His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100
105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu
Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu
Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys
Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met
Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr
Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg
Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp
Pro 210 19211PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid
from a heterologous signal peptideMOD_RES(2)..(2)Thr or any amino
acid from a heterologous signal peptideMOD_RES(3)..(3)Pro or any
amino acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or
any amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(6)..(6)Gly or any amino acid from a heterologous
signal peptideMOD_RES(7)..(7)Leu or any amino acid from a
heterologous signal peptideMOD_RES(8)..(8)Ile or any amino acid
from a heterologous signal peptideMOD_RES(9)..(9)Val or any amino
acid from a heterologous signal peptideMOD_RES(10)..(11)Leu or any
amino acid from a heterologous signal peptideMOD_RES(12)..(12)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(13)..(13)Ser or any amino acid from a heterologous
signal peptideMOD_RES(14)..(14)Trp or any amino acid from a
heterologous signal peptideMOD_RES(15)..(15)Ser or any amino acid
from a heterologous signal peptideMOD_RES(16)..(16)Leu or any amino
acid from a heterologous signal peptideMOD_RES(17)..(17)Gly or any
amino acid from a heterologous signal peptideMOD_RES(18)..(18)Asp
or any amino acid from a heterologous signal
peptideMOD_RES(19)..(19)Trp or any amino acid from a heterologous
signal peptideMOD_RES(20)..(20)Gly or any amino acid from a
heterologous signal peptideMOD_RES(21)..(21)Ala or any amino acid
from a heterologous signal peptideMOD_RES(22)..(22)Glu or any amino
acid from a heterologous signal peptideMOD_RES(23)..(23)Ala or any
amino acid from a heterologous signal peptide 19Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp
Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40
45 Asn Lys Thr Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile
50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Glu
Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly
Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly
Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe
Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly
Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys
Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn
Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170
175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys
180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile
Asn Ala 195 200 205 Thr Asp Pro 210 20211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 20Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Glu Val Val Gly 35 40 45 Asn
Lys Thr Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Glu Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 21211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 21Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Lys Val Val Gly 35 40 45 Asn Lys Thr Val Lys Glu
Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Lys
Met Tyr Arg Gly Phe Glu Lys Met Pro Glu Val Gln 65 70 75 80 Tyr Ile
His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100
105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu
Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu
Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys
Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met
Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr
Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg
Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp
Pro 210 22211PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid
from a heterologous signal peptideMOD_RES(2)..(2)Thr or any amino
acid from a heterologous signal peptideMOD_RES(3)..(3)Pro or any
amino acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or
any amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(6)..(6)Gly or any amino acid from a heterologous
signal peptideMOD_RES(7)..(7)Leu or any amino
acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or any
amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val or
any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 22Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Ser Val Val Gly 35 40 45 Lys Lys Leu Val Lys Glu
Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Lys
Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 65 70 75 80 Tyr Ile
His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100
105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu
Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu
Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys
Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met
Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr
Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg
Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp
Pro 210 23211PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid
from a heterologous signal peptideMOD_RES(2)..(2)Thr or any amino
acid from a heterologous signal peptideMOD_RES(3)..(3)Pro or any
amino acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or
any amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(6)..(6)Gly or any amino acid from a heterologous
signal peptideMOD_RES(7)..(7)Leu or any amino acid from a
heterologous signal peptideMOD_RES(8)..(8)Ile or any amino acid
from a heterologous signal peptideMOD_RES(9)..(9)Val or any amino
acid from a heterologous signal peptideMOD_RES(10)..(11)Leu or any
amino acid from a heterologous signal peptideMOD_RES(12)..(12)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(13)..(13)Ser or any amino acid from a heterologous
signal peptideMOD_RES(14)..(14)Trp or any amino acid from a
heterologous signal peptideMOD_RES(15)..(15)Ser or any amino acid
from a heterologous signal peptideMOD_RES(16)..(16)Leu or any amino
acid from a heterologous signal peptideMOD_RES(17)..(17)Gly or any
amino acid from a heterologous signal peptideMOD_RES(18)..(18)Asp
or any amino acid from a heterologous signal
peptideMOD_RES(19)..(19)Trp or any amino acid from a heterologous
signal peptideMOD_RES(20)..(20)Gly or any amino acid from a
heterologous signal peptideMOD_RES(21)..(21)Ala or any amino acid
from a heterologous signal peptideMOD_RES(22)..(22)Glu or any amino
acid from a heterologous signal peptideMOD_RES(23)..(23)Ala or any
amino acid from a heterologous signal peptide 23Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp
Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Ser Val Val Gly 35 40
45 Lys Lys Leu Val Lys Glu Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile
50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His
Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly
Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly
Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe
Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly
Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys
Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn
Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170
175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys
180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile
Asn Ala 195 200 205 Thr Asp Pro 210 24211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 24Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Ser Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Ser Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 25211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 25Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys Lys Leu Val Lys Glu
Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Lys
Met Tyr Arg Gly Phe Glu Lys Met Pro Asp Val Glu 65 70 75 80 Tyr Ile
His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100
105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu
Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu
Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys
Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met
Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr
Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg
Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp
Pro 210 26211PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid
from a heterologous signal peptideMOD_RES(2)..(2)Thr or any amino
acid from a heterologous signal peptideMOD_RES(3)..(3)Pro or any
amino acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or
any amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(6)..(6)Gly or any amino acid from a heterologous
signal peptideMOD_RES(7)..(7)Leu or any amino acid from a
heterologous signal peptideMOD_RES(8)..(8)Ile or any amino acid
from a heterologous signal peptideMOD_RES(9)..(9)Val or any amino
acid from a heterologous signal peptideMOD_RES(10)..(11)Leu or any
amino acid from a heterologous signal peptideMOD_RES(12)..(12)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(13)..(13)Ser or any amino acid from a heterologous
signal peptideMOD_RES(14)..(14)Trp or any amino acid from a
heterologous signal peptideMOD_RES(15)..(15)Ser or any amino acid
from a heterologous signal peptideMOD_RES(16)..(16)Leu or any amino
acid from a heterologous signal peptideMOD_RES(17)..(17)Gly or any
amino acid from a heterologous signal peptideMOD_RES(18)..(18)Asp
or any amino acid from a heterologous signal
peptideMOD_RES(19)..(19)Trp or any amino acid from a heterologous
signal peptideMOD_RES(20)..(20)Gly or any amino acid from a
heterologous signal peptideMOD_RES(21)..(21)Ala or any amino acid
from a heterologous signal peptideMOD_RES(22)..(22)Glu or any amino
acid from a heterologous signal peptideMOD_RES(23)..(23)Ala or any
amino acid from a heterologous signal peptide 26Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp
Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Asn Val Thr Gly 35 40
45 Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile
50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His
Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly
Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly
Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe
Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly
Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys
Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn
Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170
175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys
180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile
Asn Ala 195 200 205 Thr Asp Pro 210 27211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a
heterologous signal peptideMOD_RES(14)..(14)Trp or any amino acid
from a heterologous signal peptideMOD_RES(15)..(15)Ser or any amino
acid from a heterologous signal peptideMOD_RES(16)..(16)Leu or any
amino acid from a heterologous signal peptideMOD_RES(17)..(17)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(18)..(18)Asp or any amino acid from a heterologous
signal peptideMOD_RES(19)..(19)Trp or any amino acid from a
heterologous signal peptideMOD_RES(20)..(20)Gly or any amino acid
from a heterologous signal peptideMOD_RES(21)..(21)Ala or any amino
acid from a heterologous signal peptideMOD_RES(22)..(22)Glu or any
amino acid from a heterologous signal peptideMOD_RES(23)..(23)Ala
or any amino acid from a heterologous signal peptide 27Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25
30 Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly
35 40 45 Asn Lys Thr Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr
Thr Ile 50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met
Pro His Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu
Cys Gly Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu
Thr Gly Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys
Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg
Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys
Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155
160 Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly
165 170 175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly
Tyr Cys 180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser
Ile Ile Asn Ala 195 200 205 Thr Asp Pro 210 28211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 28Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Ser
Lys Leu Val Lys Glu Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 29211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 29Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Lys Val Val Gly 35 40 45 Ser Lys Leu Val Lys Glu
Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Ser
Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 65 70 75 80 Tyr Ile
His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100
105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu
Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu
Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys
Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met
Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr
Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg
Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp
Pro 210 30211PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid
from a heterologous signal peptideMOD_RES(2)..(2)Thr or any amino
acid from a heterologous signal peptideMOD_RES(3)..(3)Pro or any
amino acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or
any amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(6)..(6)Gly or any amino acid from a heterologous
signal peptideMOD_RES(7)..(7)Leu or any amino acid from a
heterologous signal peptideMOD_RES(8)..(8)Ile or any amino acid
from a heterologous signal peptideMOD_RES(9)..(9)Val or any amino
acid from a heterologous signal peptideMOD_RES(10)..(11)Leu or any
amino acid from a heterologous signal peptideMOD_RES(12)..(12)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(13)..(13)Ser or any amino acid from a heterologous
signal peptideMOD_RES(14)..(14)Trp or any amino acid from a
heterologous signal peptideMOD_RES(15)..(15)Ser or any amino acid
from a heterologous signal peptideMOD_RES(16)..(16)Leu or any amino
acid from a heterologous signal peptideMOD_RES(17)..(17)Gly or any
amino acid from a heterologous signal peptideMOD_RES(18)..(18)Asp
or any amino acid from a heterologous signal
peptideMOD_RES(19)..(19)Trp or any amino acid from a heterologous
signal peptideMOD_RES(20)..(20)Gly or any amino acid from a
heterologous signal peptideMOD_RES(21)..(21)Ala or any amino acid
from a heterologous signal peptideMOD_RES(22)..(22)Glu or any amino
acid from a heterologous signal peptideMOD_RES(23)..(23)Ala or any
amino acid from a heterologous signal peptide 30Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp
Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40
45 Lys Asn Leu Thr Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile
50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His
Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly
Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly
Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe
Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly
Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys
Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn
Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170
175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys
180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile
Asn Ala 195 200 205 Thr Asp Pro 210 31211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 31Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Asn Phe Thr Thr Leu Val Tyr Thr Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 32211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous
signal peptideMOD_RES(19)..(19)Trp or any amino acid from a
heterologous signal peptideMOD_RES(20)..(20)Gly or any amino acid
from a heterologous signal peptideMOD_RES(21)..(21)Ala or any amino
acid from a heterologous signal peptideMOD_RES(22)..(22)Glu or any
amino acid from a heterologous signal peptideMOD_RES(23)..(23)Ala
or any amino acid from a heterologous signal peptide 32Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25
30 Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly
35 40 45 Lys Lys Leu Val Lys Glu Gly Asn Phe Thr Thr Leu Val Tyr
Asn Ile 50 55 60 Thr Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met
Pro His Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu
Cys Gly Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu
Thr Gly Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys
Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg
Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys
Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155
160 Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly
165 170 175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly
Tyr Cys 180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser
Ile Ile Asn Ala 195 200 205 Thr Asp Pro 210 33211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 33Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 34211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 34Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys Lys Leu Val Lys Glu
Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Ser
Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 65 70 75 80 Tyr Ile
His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100
105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu
Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu
Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys
Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met
Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr
Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg
Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp
Pro 210 35211PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid
from a heterologous signal peptideMOD_RES(2)..(2)Thr or any amino
acid from a heterologous signal peptideMOD_RES(3)..(3)Pro or any
amino acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or
any amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(6)..(6)Gly or any amino acid from a heterologous
signal peptideMOD_RES(7)..(7)Leu or any amino acid from a
heterologous signal peptideMOD_RES(8)..(8)Ile or any amino acid
from a heterologous signal peptideMOD_RES(9)..(9)Val or any amino
acid from a heterologous signal peptideMOD_RES(10)..(11)Leu or any
amino acid from a heterologous signal peptideMOD_RES(12)..(12)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(13)..(13)Ser or any amino acid from a heterologous
signal peptideMOD_RES(14)..(14)Trp or any amino acid from a
heterologous signal peptideMOD_RES(15)..(15)Ser or any amino acid
from a heterologous signal peptideMOD_RES(16)..(16)Leu or any amino
acid from a heterologous signal peptideMOD_RES(17)..(17)Gly or any
amino acid from a heterologous signal peptideMOD_RES(18)..(18)Asp
or any amino acid from a heterologous signal
peptideMOD_RES(19)..(19)Trp or any amino acid from a heterologous
signal peptideMOD_RES(20)..(20)Gly or any amino acid from a
heterologous signal peptideMOD_RES(21)..(21)Ala or any amino acid
from a heterologous signal peptideMOD_RES(22)..(22)Glu or any amino
acid from a heterologous signal peptideMOD_RES(23)..(23)Ala or any
amino acid from a heterologous signal peptide 35Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp
Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40
45 Lys Lys Leu Val Lys Glu Gly Pro Asn Gly Thr Leu Val Tyr Thr Ile
50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His
Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly
Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly
Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe
Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Ser Gly
Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys
Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn
Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170
175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys
180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile
Asn Ala 195 200 205 Thr Asp Pro 210 36211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 36Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Asn Ile 50 55
60 Thr Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 37211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 37Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp
Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40
45 Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile
50 55 60 Asn Gln Thr Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His
Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly
Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly
Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe
Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly
Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys
Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn
Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170
175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys
180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile
Asn Ala 195 200 205 Thr Asp Pro 210 38211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 38Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Asn Met Thr His Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 39211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 39Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys Lys Leu Val Lys Glu
Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Lys
Met Tyr Arg Gly Phe Thr Lys Met Pro Asn Val Thr 65 70 75 80 Tyr Ile
His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100
105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu
Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu
Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys
Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met
Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr
Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg
Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp
Pro 210 40211PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid
from a heterologous signal peptideMOD_RES(2)..(2)Thr or any amino
acid from a heterologous signal peptideMOD_RES(3)..(3)Pro or any
amino acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or
any amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(6)..(6)Gly or any amino acid from a heterologous
signal peptideMOD_RES(7)..(7)Leu or any amino acid from a
heterologous signal peptideMOD_RES(8)..(8)Ile or any amino acid
from a heterologous signal peptideMOD_RES(9)..(9)Val or any amino
acid from a heterologous signal peptideMOD_RES(10)..(11)Leu or any
amino acid from a heterologous signal peptideMOD_RES(12)..(12)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(13)..(13)Ser or any amino acid from a heterologous
signal peptideMOD_RES(14)..(14)Trp or any amino acid from a
heterologous signal peptideMOD_RES(15)..(15)Ser or any amino acid
from a heterologous signal peptideMOD_RES(16)..(16)Leu or any amino
acid from a heterologous signal peptideMOD_RES(17)..(17)Gly or any
amino acid from a heterologous signal peptideMOD_RES(18)..(18)Asp
or any amino acid from a heterologous signal
peptideMOD_RES(19)..(19)Trp or any amino acid from a heterologous
signal peptideMOD_RES(20)..(20)Gly or any amino acid from a
heterologous signal peptideMOD_RES(21)..(21)Ala or any amino acid
from a heterologous signal peptideMOD_RES(22)..(22)Glu or any amino
acid from a heterologous signal peptideMOD_RES(23)..(23)Ala or any
amino acid from a heterologous signal peptide 40Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp
Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40
45 Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile
50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His
Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly
Leu Asn Leu Thr 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly
Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe
Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly
Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys
Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn
Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170
175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys
180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile
Asn Ala 195 200 205 Thr Asp Pro 210 41211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 41Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Asn 85 90 95 Val Thr Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 42211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 42Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys Lys Leu Val Lys Glu
Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50
55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val
Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu
Lys Leu Glu 85 90 95 Asn Asn Thr Tyr Gln Tyr Leu Leu Thr Gly Arg
Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val
Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu
Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser
Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu
Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175
Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180
185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn
Ala 195 200 205 Thr Asp Pro 210 43211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 43Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asn Gly Thr 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 44211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 44Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys Lys Leu Val Lys Glu
Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Lys
Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 65 70 75 80 Tyr Ile
His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100
105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Asn Leu
Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu
Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys
Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met
Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr
Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg
Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp
Pro 210 45211PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid
from a heterologous signal peptideMOD_RES(2)..(2)Thr or any amino
acid from a heterologous signal peptideMOD_RES(3)..(3)Pro or any
amino acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or
any amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(6)..(6)Gly or any amino acid from a heterologous
signal peptideMOD_RES(7)..(7)Leu or any amino acid from a
heterologous signal peptideMOD_RES(8)..(8)Ile or any amino acid
from a heterologous signal peptideMOD_RES(9)..(9)Val or any amino
acid from a heterologous signal peptideMOD_RES(10)..(11)Leu or any
amino acid from a heterologous signal peptideMOD_RES(12)..(12)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(13)..(13)Ser or any amino acid from a heterologous
signal peptideMOD_RES(14)..(14)Trp or any amino acid from a
heterologous signal peptideMOD_RES(15)..(15)Ser or any amino acid
from a heterologous signal peptideMOD_RES(16)..(16)Leu or any amino
acid from a heterologous signal peptideMOD_RES(17)..(17)Gly or any
amino acid from a heterologous signal peptideMOD_RES(18)..(18)Asp
or any amino acid from a heterologous signal
peptideMOD_RES(19)..(19)Trp or any amino acid from a heterologous
signal peptideMOD_RES(20)..(20)Gly or any amino acid from a
heterologous signal peptideMOD_RES(21)..(21)Ala or any amino acid
from a heterologous signal peptideMOD_RES(22)..(22)Glu or any amino
acid from a heterologous signal peptideMOD_RES(23)..(23)Ala or any
amino acid from a heterologous signal peptide 45Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp
Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40
45 Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile
50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His
Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly
Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly
Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe
Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly
Leu Asn Tyr Thr Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys
Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn
Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170
175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys
180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile
Asn Ala 195 200 205 Thr Asp Pro 210 46211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 46Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Asn Tyr Thr Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 47211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 47Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys Lys Leu Val Lys Glu
Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Lys
Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 65 70 75 80 Tyr Ile
His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100
105 110 Met Tyr
Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 115 120 125
Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130
135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Asn Ser
Thr 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe
Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg
Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro
Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp Pro 210
48211PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid from a
heterologous signal peptideMOD_RES(2)..(2)Thr or any amino acid
from a heterologous signal peptideMOD_RES(3)..(3)Pro or any amino
acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or any
amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or
any amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(7)..(7)Leu or any amino acid from a heterologous
signal peptideMOD_RES(8)..(8)Ile or any amino acid from a
heterologous signal peptideMOD_RES(9)..(9)Val or any amino acid
from a heterologous signal peptideMOD_RES(10)..(11)Leu or any amino
acid from a heterologous signal peptideMOD_RES(12)..(12)Gly or any
amino acid from a heterologous signal peptideMOD_RES(13)..(13)Ser
or any amino acid from a heterologous signal
peptideMOD_RES(14)..(14)Trp or any amino acid from a heterologous
signal peptideMOD_RES(15)..(15)Ser or any amino acid from a
heterologous signal peptideMOD_RES(16)..(16)Leu or any amino acid
from a heterologous signal peptideMOD_RES(17)..(17)Gly or any amino
acid from a heterologous signal peptideMOD_RES(18)..(18)Asp or any
amino acid from a heterologous signal peptideMOD_RES(19)..(19)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(20)..(20)Gly or any amino acid from a heterologous
signal peptideMOD_RES(21)..(21)Ala or any amino acid from a
heterologous signal peptideMOD_RES(22)..(22)Glu or any amino acid
from a heterologous signal peptideMOD_RES(23)..(23)Ala or any amino
acid from a heterologous signal peptide 48Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala
Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45
Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50
55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val
Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu
Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg
Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val
Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu
Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser
Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu
Cys Leu Trp Asn Asp Thr Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175
Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180
185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn
Ala 195 200 205 Thr Asp Pro 210 49211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 49Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Thr Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 50211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 50Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys Lys Leu Val Lys Glu
Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Lys
Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 65 70 75 80 Tyr Ile
His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100
105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu
Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu
Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys
Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met
Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys Asn Tyr
Thr Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg
Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp
Pro 210 51211PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid
from a heterologous signal peptideMOD_RES(2)..(2)Thr or any amino
acid from a heterologous signal peptideMOD_RES(3)..(3)Pro or any
amino acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or
any amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(6)..(6)Gly or any amino acid from a heterologous
signal peptideMOD_RES(7)..(7)Leu or any amino acid from a
heterologous signal peptideMOD_RES(8)..(8)Ile or any amino acid
from a heterologous signal peptideMOD_RES(9)..(9)Val or any amino
acid from a heterologous signal peptideMOD_RES(10)..(11)Leu or any
amino acid from a heterologous signal peptideMOD_RES(12)..(12)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(13)..(13)Ser or any amino acid from a heterologous
signal peptideMOD_RES(14)..(14)Trp or any amino acid from a
heterologous signal peptideMOD_RES(15)..(15)Ser or any amino acid
from a heterologous signal peptideMOD_RES(16)..(16)Leu or any amino
acid from a heterologous signal peptideMOD_RES(17)..(17)Gly or any
amino acid from a heterologous signal peptideMOD_RES(18)..(18)Asp
or any amino acid from a heterologous signal
peptideMOD_RES(19)..(19)Trp or any amino acid from a heterologous
signal peptideMOD_RES(20)..(20)Gly or any amino acid from a
heterologous signal peptideMOD_RES(21)..(21)Ala or any amino acid
from a heterologous signal peptideMOD_RES(22)..(22)Glu or any amino
acid from a heterologous signal peptideMOD_RES(23)..(23)Ala or any
amino acid from a heterologous signal peptide 51Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp
Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40
45 Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile
50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His
Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly
Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly
Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe
Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly
Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys
Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn
Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170
175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Asn Gln Thr Gly Gly Tyr Cys
180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile
Asn Ala 195 200 205 Thr Asp Pro 210 52211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 52Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly
165 170 175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly
Tyr Cys 180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Asn Asp Thr Ser
Ile Ile Asn Ala 195 200 205 Thr Asp Pro 210 53211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 53Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Thr Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Glu Lys Met Pro Asp Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala
195 200 205 Thr Asp Pro 210 54211PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or
any amino acid from a heterologous signal peptideMOD_RES(2)..(2)Thr
or any amino acid from a heterologous signal
peptideMOD_RES(3)..(3)Pro or any amino acid from a heterologous
signal peptideMOD_RES(4)..(4)Trp or any amino acid from a
heterologous signal peptideMOD_RES(5)..(5)Leu or any amino acid
from a heterologous signal peptideMOD_RES(6)..(6)Gly or any amino
acid from a heterologous signal peptideMOD_RES(7)..(7)Leu or any
amino acid from a heterologous signal peptideMOD_RES(8)..(8)Ile or
any amino acid from a heterologous signal peptideMOD_RES(9)..(9)Val
or any amino acid from a heterologous signal
peptideMOD_RES(10)..(11)Leu or any amino acid from a heterologous
signal peptideMOD_RES(12)..(12)Gly or any amino acid from a
heterologous signal peptideMOD_RES(13)..(13)Ser or any amino acid
from a heterologous signal peptideMOD_RES(14)..(14)Trp or any amino
acid from a heterologous signal peptideMOD_RES(15)..(15)Ser or any
amino acid from a heterologous signal peptideMOD_RES(16)..(16)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(17)..(17)Gly or any amino acid from a heterologous
signal peptideMOD_RES(18)..(18)Asp or any amino acid from a
heterologous signal peptideMOD_RES(19)..(19)Trp or any amino acid
from a heterologous signal peptideMOD_RES(20)..(20)Gly or any amino
acid from a heterologous signal peptideMOD_RES(21)..(21)Ala or any
amino acid from a heterologous signal peptideMOD_RES(22)..(22)Glu
or any amino acid from a heterologous signal
peptideMOD_RES(23)..(23)Ala or any amino acid from a heterologous
signal peptide 54Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Cys
Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe Cys Asn Ser Asp Ile
Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys Lys Asn Val Thr Glu
Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55 60 Lys Gln Met Lys
Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 65 70 75 80 Tyr Ile
His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 85 90 95
Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 100
105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu
Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu
Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys
Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys Leu Trp Thr Asp Met
Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr Gln Ser Lys His Tyr
Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185 190 Ser Trp Tyr Arg
Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 195 200 205 Thr Asp
Pro 210 55211PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideMOD_RES(1)..(1)Met or any amino acid
from a heterologous signal peptideMOD_RES(2)..(2)Thr or any amino
acid from a heterologous signal peptideMOD_RES(3)..(3)Pro or any
amino acid from a heterologous signal peptideMOD_RES(4)..(4)Trp or
any amino acid from a heterologous signal peptideMOD_RES(5)..(5)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(6)..(6)Gly or any amino acid from a heterologous
signal peptideMOD_RES(7)..(7)Leu or any amino acid from a
heterologous signal peptideMOD_RES(8)..(8)Ile or any amino acid
from a heterologous signal peptideMOD_RES(9)..(9)Val or any amino
acid from a heterologous signal peptideMOD_RES(10)..(11)Leu or any
amino acid from a heterologous signal peptideMOD_RES(12)..(12)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(13)..(13)Ser or any amino acid from a heterologous
signal peptideMOD_RES(14)..(14)Trp or any amino acid from a
heterologous signal peptideMOD_RES(15)..(15)Ser or any amino acid
from a heterologous signal peptideMOD_RES(16)..(16)Leu or any amino
acid from a heterologous signal peptideMOD_RES(17)..(17)Gly or any
amino acid from a heterologous signal peptideMOD_RES(18)..(18)Asp
or any amino acid from a heterologous signal
peptideMOD_RES(19)..(19)Trp or any amino acid from a heterologous
signal peptideMOD_RES(20)..(20)Gly or any amino acid from a
heterologous signal peptideMOD_RES(21)..(21)Ala or any amino acid
from a heterologous signal peptideMOD_RES(22)..(22)Glu or any amino
acid from a heterologous signal peptideMOD_RES(23)..(23)Ala or any
amino acid from a heterologous signal peptide 55Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp
Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40
45 Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile
50 55 60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His
Val Gln 65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly
Leu Lys Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly
Arg Val Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe
Val Glu Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly
Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys
Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn
Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170
175 Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys
180 185 190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile
Asn Tyr 195 200 205 Thr Asp Pro 210 56211PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideMOD_RES(1)..(1)Met or any amino acid from a heterologous
signal peptideMOD_RES(2)..(2)Thr or any amino acid from a
heterologous signal peptideMOD_RES(3)..(3)Pro or any amino acid
from a heterologous signal peptideMOD_RES(4)..(4)Trp or any amino
acid from a heterologous signal peptideMOD_RES(5)..(5)Leu or any
amino acid from a heterologous signal peptideMOD_RES(6)..(6)Gly or
any amino acid from a heterologous signal peptideMOD_RES(7)..(7)Leu
or any amino acid from a heterologous signal
peptideMOD_RES(8)..(8)Ile or any amino acid from a heterologous
signal peptideMOD_RES(9)..(9)Val or any amino acid from a
heterologous signal peptideMOD_RES(10)..(11)Leu or any amino acid
from a heterologous signal peptideMOD_RES(12)..(12)Gly or any amino
acid from a heterologous signal peptideMOD_RES(13)..(13)Ser or any
amino acid from a heterologous signal peptideMOD_RES(14)..(14)Trp
or any amino acid from a heterologous signal
peptideMOD_RES(15)..(15)Ser or any amino acid from a heterologous
signal peptideMOD_RES(16)..(16)Leu or any amino acid from a
heterologous signal peptideMOD_RES(17)..(17)Gly or any amino acid
from a heterologous signal peptideMOD_RES(18)..(18)Asp or any amino
acid from a heterologous signal peptideMOD_RES(19)..(19)Trp or any
amino acid from a heterologous signal peptideMOD_RES(20)..(20)Gly
or any amino acid from a heterologous signal
peptideMOD_RES(21)..(21)Ala or any amino acid from a heterologous
signal peptideMOD_RES(22)..(22)Glu or any amino acid from a
heterologous signal peptideMOD_RES(23)..(23)Ala or any amino acid
from a heterologous signal peptide 56Xaa Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Cys Thr Cys Ser Pro Ser His Pro Gln 20 25 30 Asp Ala Phe
Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 35 40 45 Lys
Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 50 55
60 Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln
65 70 75 80 Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys
Leu Glu 85 90 95 Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val
Tyr Asp Gly Lys 100 105 110 Met Tyr Thr Gly Leu Cys Asn Phe Val Glu
Arg Trp Asp Gln Leu Thr 115 120 125 Leu Ser Gln Arg Lys Gly Leu Asn
Tyr Arg Tyr His Leu Gly Cys Asn 130 135 140 Cys Lys Ile Lys Ser Cys
Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 145 150 155 160 Asn Glu Cys
Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 165 170 175 Tyr
Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 180 185
190 Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Val
195 200 205 Thr Asp Pro 210 57188PRTHomo sapienshuTIMP3(K45S, F57N,
I205F, A208G) 57Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys
Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys
Leu Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile
Lys Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His
Val Gln Tyr Ile His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly
Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly
Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe
Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105
110 Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr
115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp
Thr Asp 130 135 140 Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser
Lys His Tyr Ala 145 150 155 160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys
Ser Trp Tyr Arg Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Phe Ile
Asn Gly Thr Asp Pro 180 185 58188PRTHomo sapienshuTIMP3(K45S, F57N,
A208G) 58Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn
Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu
Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys
Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val
Gln Tyr Ile His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu
Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg
Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val
Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110
Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115
120 125 Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr
Asp 130 135 140 Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys
His Tyr Ala 145 150 155 160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser
Trp Tyr Arg Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn
Gly Thr Asp Pro 180 185 59188PRTHomo sapienshuTIMP3(K45S, F57N,
I205Y) 59Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn
Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu
Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys
Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val
Gln Tyr Ile His Thr Glu Ala Ser 50 55 60
Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr Leu 65
70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu
Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln
Arg Lys Gly Leu 100 105 110 Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys
Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser
Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu Ser Asn Phe Gly
Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155 160 Cys Ile Arg
Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 165 170 175 Pro
Pro Asp Lys Ser Tyr Ile Asn Ala Thr Asp Pro 180 185 60188PRTHomo
sapienshuTIMP3(K45S, F57N, I205Y, A208G) 60Cys Thr Cys Ser Pro Ser
His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile Val Ile Arg
Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 20 25 30 Pro Asn
Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 35 40 45
Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 50
55 60 Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Lys Tyr Gln Tyr
Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly
Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser
Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Arg Tyr His Leu Gly Cys Asn
Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys Phe Val Thr
Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu Ser Asn Phe
Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155 160 Cys Ile
Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 165 170 175
Pro Pro Asp Lys Ser Tyr Ile Asn Gly Thr Asp Pro 180 185
61188PRTHomo sapiens
huTIMP3(K45N,V47T,F57N,K75N,P77T,K94N,E96T,R138T,G173T) 61Cys Thr
Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15
Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 20
25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr
Arg 35 40 45 Gly Phe Thr Asn Met Thr His Val Gln Tyr Ile His Thr
Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn
Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys
Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln
Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His
Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro
Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met
Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150
155 160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp
Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180
185 62188PRTHomo
sapienshuTIMP3(K45N,V47T,F57N,K94N,E96T,R138T,G173T) 62Cys Thr Cys
Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile
Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 20 25
30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg
35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu
Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys
Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met
Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu
Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His Leu
Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys
Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu
Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155
160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala
165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185
63188PRTHomo sapienshuTIMP3(K45N,V47T,K50N,V52T,F57N,V97N,K99T)
63Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1
5 10 15 Ile Val Ile Arg Ala Asn Val Thr Gly Lys Asn Leu Thr Lys Glu
Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys
Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile
His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Lys Leu Glu
Asn Asn Thr Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp
Gly Lys Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp
Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Arg
Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr
Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135
140 Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala
145 150 155 160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg
Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp
Pro 180 185 64188PRTHomo sapiens
huTIMP3(K45S,K50N,V52T,F57N,V97N,K99T,R186N,K188T) 64Cys Thr Cys
Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile
Val Ile Arg Ala Ser Val Val Gly Lys Asn Leu Thr Lys Glu Gly 20 25
30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg
35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu
Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn Thr
Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met
Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu
Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Arg Tyr His Leu
Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys
Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu
Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155
160 Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala
165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185
65188PRTHomo sapiens
huTIMP3(K45S,F57N,K94N,E96T,D110N,K112T,R138T,G173T) 65Cys Thr Cys
Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile
Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 20 25
30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg
35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu
Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys
Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asn Gly Thr Met
Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu
Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His Leu
Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys
Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu
Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155
160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala
165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185
66188PRTHomo sapienshuTIMP3(K45S,F57N,T63N,K65T,K94N,E96T,G173T)
66Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1
5 10 15 Ile Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu
Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr Asn Ile Thr Gln Met Lys
Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile
His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr
Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp
Gly Lys Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp
Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Arg
Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr
Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135
140 Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala
145 150 155 160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg
Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp
Pro 180 185 67188PRTHomo sapiens
huTIMP3(K45N,V47T,K50N,V52T,F57N,V97N,K99T,R138T,R186N,K188T) 67Cys
Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10
15 Ile Val Ile Arg Ala Asn Val Thr Gly Lys Asn Leu Thr Lys Glu Gly
20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met
Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His
Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn
Asn Thr Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly
Lys Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp
Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr
His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu
Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140
Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145
150 155 160 Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly
Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro
180 185 68188PRTHomo sapiens
huTIMP3(K45S,F57N,T63N,K65T,K94N,E96T,Q126N,R138T) 68Cys Thr Cys
Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile
Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 20 25
30 Pro Asn Gly Thr Leu Val Tyr Asn Ile Thr Gln Met Lys Met Tyr Arg
35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu
Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys
Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met
Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Asn Leu
Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His Leu
Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys
Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu
Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155
160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala
165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185
69188PRTHomo sapiens
huTIMP3(K45N,V47T,K50N,V52T,F57N,V97N,K99T,R186N,K188T) 69Cys Thr
Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15
Ile Val Ile Arg Ala Asn Val Thr Gly Lys Asn Leu Thr Lys Glu Gly 20
25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr
Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr
Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn
Thr Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys
Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln
Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Arg Tyr His
Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro
Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met
Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150
155 160 Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp
Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180
185 70188PRTHomo sapiens
huTIMP3(K45N,V47T,K50N,V52T,V97N,K99T,R138T,R186N,K188T) 70Cys Thr
Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15
Ile Val Ile Arg Ala Asn Val Thr Gly Lys Asn Leu Thr Lys Glu Gly 20
25 30 Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr
Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr
Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn
Thr Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys
Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln
Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His
Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro
Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met
Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145
150
155 160 Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp
Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180
185 71188PRTHomo sapiens
huTIMP3(K45S,F57N,H78N,Q80T,K94N,E96T,R138T,G173T) 71Cys Thr Cys
Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile
Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 20 25
30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg
35 40 45 Gly Phe Thr Lys Met Pro Asn Val Thr Tyr Ile His Thr Glu
Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys
Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met
Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu
Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His Leu
Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys
Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu
Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155
160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala
165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185
72188PRTHomo sapiens
huTIMP3(K45S,F57N,K75N,P77T,K94N,E96T,R138T,G173T) 72Cys Thr Cys
Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile
Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 20 25
30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg
35 40 45 Gly Phe Thr Asn Met Thr His Val Gln Tyr Ile His Thr Glu
Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys
Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met
Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu
Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His Leu
Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys
Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu
Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155
160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala
165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185
73188PRTHomo sapiens
huTIMP3(K45N,V47T,K50N,V52T,V97N,K99T,G173T,R186N,K188T) 73Cys Thr
Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15
Ile Val Ile Arg Ala Asn Val Thr Gly Lys Asn Leu Thr Lys Glu Gly 20
25 30 Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr
Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr
Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn
Thr Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys
Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln
Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Arg Tyr His
Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro
Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met
Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150
155 160 Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp
Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180
185 74188PRTHomo sapienshuTIMP3(K45E,F57N,Q126N,R138T,G173T) 74Cys
Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10
15 Ile Val Ile Arg Ala Glu Val Val Gly Lys Lys Leu Val Lys Glu Gly
20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met
Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His
Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Lys Leu Glu Val
Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly
Lys Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp
Asn Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr
His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu
Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140
Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145
150 155 160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly
Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro
180 185 75188PRTHomo sapiens
huTIMP3(K45S,F57N,T63N,K65T,K94N,E96T,R138T,G173T) 75Cys Thr Cys
Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile
Val Ile Arg Ala Ser Val Val Gly Lys Lys Leu Val Lys Glu Gly 20 25
30 Pro Asn Gly Thr Leu Val Tyr Asn Ile Thr Gln Met Lys Met Tyr Arg
35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu
Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys
Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met
Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu
Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His Leu
Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys
Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu
Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155
160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala
165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185
76188PRTHomo sapiens
huTIMP3(K45S,K50N,V52T,F57N,V97N,K99T,R138T,R186N,K188T) 76Cys Thr
Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15
Ile Val Ile Arg Ala Ser Val Val Gly Lys Asn Leu Thr Lys Glu Gly 20
25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr
Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr
Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn
Thr Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys
Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln
Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His
Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro
Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met
Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150
155 160 Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp
Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180
185 77188PRTHomo sapiens
huTIMP3(K45S.K50N,V52T,F57N,V97N,K99T,G173T,R186N,K188T) 77Cys Thr
Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15
Ile Val Ile Arg Ala Ser Val Val Gly Lys Asn Leu Thr Lys Glu Gly 20
25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr
Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr
Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Lys Leu Glu Asn Asn
Thr Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys
Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln
Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Arg Tyr His
Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro
Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met
Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150
155 160 Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp
Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180
185 78188PRTHomo sapiens huTIMP3(K45N,V47T, F57N, K94N,E96T, G173T,
R186N,K188T) 78Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys
Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys
Leu Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile
Lys Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His
Val Gln Tyr Ile His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly
Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly
Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe
Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105
110 Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr
115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp
Thr Asp 130 135 140 Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser
Lys His Tyr Ala 145 150 155 160 Cys Ile Asn Gln Thr Gly Gly Tyr Cys
Ser Trp Tyr Arg Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile
Asn Ala Thr Asp Pro 180 185 79188PRTHomo sapiens huTIMP3(K45N,V47T,
F57N, K94N,E96T, D110N,K112T, R186N,K188T) 79Cys Thr Cys Ser Pro
Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile Val Ile
Arg Ala Asn Val Thr Gly Lys Lys Leu Val Lys Glu Gly 20 25 30 Pro
Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 35 40
45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser
50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln
Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr
Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu Thr Leu
Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Arg Tyr His Leu Gly Cys
Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys Phe Val
Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu Ser Asn
Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155 160 Cys
Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 165 170
175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185
80188PRTHomo sapiens huTIMP3(K45N,V47T, F57N, V97N,K99T, R138T,
G173T) 80Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn
Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys Leu
Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys
Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val
Gln Tyr Ile His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu
Lys Leu Glu Asn Asn Thr Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg
Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val
Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110
Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115
120 125 Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr
Asp 130 135 140 Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys
His Tyr Ala 145 150 155 160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser
Trp Tyr Arg Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn
Ala Thr Asp Pro 180 185 81188PRTHomo sapiens huTIMP3(K45N,V47T,
F57N, K99E G173T, R186N,K188T) 81Cys Thr Cys Ser Pro Ser His Pro
Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Asn
Val Thr Gly Lys Lys Leu Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr
Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe
Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 50 55 60
Glu Ser Leu Cys Gly Leu Lys Leu Glu Val Asn Glu Tyr Gln Tyr Leu 65
70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu
Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln
Arg Lys Gly Leu 100 105 110 Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys
Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser
Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu Ser Asn Phe Thr
Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155 160 Cys Ile Asn
Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 165 170 175 Pro
Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185 82188PRTHomo
sapienshuTIMP3(K45E, K49E, F57N, K94N,E96T, D110N,K112T, G173T,
R186N,K188T) 82Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys
Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Glu Val Val Gly Glu Lys
Leu Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile
Lys Gln Met Lys Met Tyr Arg 35 40 45
Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 50
55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr
Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly
Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser
Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Arg Tyr His Leu Gly Cys Asn
Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys Phe Val Thr
Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu Ser Asn Phe
Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155 160 Cys Ile
Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 165 170 175
Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185
83188PRTHomo sapienshuTIMP3(K50N,V52T, K94N,E96T, R138T, G173T)
83Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1
5 10 15 Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu
Gly 20 25 30 Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys
Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile
His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr
Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp
Gly Lys Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp
Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr
Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr
Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135
140 Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala
145 150 155 160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg
Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp
Pro 180 185 84188PRTHomo sapienshuTIMP3(K45E, K50N,V52T, K94N,E96T,
D110N,K112T, R138T, G173T) 84Cys Thr Cys Ser Pro Ser His Pro Gln
Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Glu Val
Val Gly Lys Asn Leu Thr Lys Glu Gly 20 25 30 Pro Phe Gly Thr Leu
Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe Thr
Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 50 55 60 Glu
Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 65 70
75 80 Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys
Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg
Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys
Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser Lys
Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu Ser Asn Phe Thr Tyr
Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155 160 Cys Ile Arg Gln
Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 165 170 175 Pro Pro
Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185 85188PRTHomo
sapienshuTIMP3(K50N,V52T, K94N,E96T, R138T, G173T, R186N,K188T)
85Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1
5 10 15 Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu
Gly 20 25 30 Pro Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys
Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile
His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr
Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp
Gly Lys Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp
Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr
Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr
Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135
140 Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala
145 150 155 160 Cys Ile Asn Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg
Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp
Pro 180 185 86188PRTHomo sapienshuTIMP3(K45E, F57N ,T63N,K65T,
K94N,E96T ,G173T, R186N,K188T) 86Cys Thr Cys Ser Pro Ser His Pro
Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Glu
Val Val Gly Lys Lys Leu Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr
Leu Val Tyr Asn Ile Thr Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe
Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 50 55 60
Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 65
70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu
Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln
Arg Lys Gly Leu 100 105 110 Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys
Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser
Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu Ser Asn Phe Thr
Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155 160 Cys Ile Asn
Gln Thr Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 165 170 175 Pro
Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185 87188PRTHomo
sapienshuTIMP3(K45N,V47T, F57N, K94N,E96T, D110N,K112T, G173T,
R186Q,K188Q) 87Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys
Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Asn Val Thr Gly Lys Lys
Leu Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile
Lys Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His
Val Gln Tyr Ile His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly
Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly
Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe
Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105
110 Asn Tyr Arg Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr
115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp
Thr Asp 130 135 140 Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser
Lys His Tyr Ala 145 150 155 160 Cys Ile Gln Gln Gln Gly Gly Tyr Cys
Ser Trp Tyr Arg Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile
Asn Ala Thr Asp Pro 180 185 88188PRTHomo sapiensHuTIMP3(K45S, F57N,
K94N, E96T, R138T, G173T) 88Cys Thr Cys Ser Pro Ser His Pro Gln Asp
Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Ser Val Val
Gly Lys Lys Leu Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr Leu Val
Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe Thr Lys
Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 50 55 60 Glu Ser
Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80
Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 85
90 95 Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly
Leu 100 105 110 Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys
Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu
Cys Leu Trp Thr Asp 130 135 140 Met Leu Ser Asn Phe Thr Tyr Pro Gly
Tyr Gln Ser Lys His Tyr Ala 145 150 155 160 Cys Ile Arg Gln Lys Gly
Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 165 170 175 Pro Pro Asp Lys
Ser Ile Ile Asn Ala Thr Asp Pro 180 185 89188PRTHomo
sapiensHuTIMP3(K45E, F57N, K94N, E96T, R138T, G173T) 89Cys Thr Cys
Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile
Val Ile Arg Ala Glu Val Val Gly Lys Lys Leu Val Lys Glu Gly 20 25
30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg
35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu
Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys
Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met
Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu
Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His Leu
Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys
Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu
Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155
160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala
165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185
90188PRTHomo sapiensHuTIMP3(K45E, F57N, K94N, E96T, D110N, K112T,
R138T, G173T) 90Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys
Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Glu Val Val Gly Lys Lys
Leu Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile
Lys Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His
Val Gln Tyr Ile His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly
Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly
Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe
Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105
110 Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr
115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp
Thr Asp 130 135 140 Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser
Lys His Tyr Ala 145 150 155 160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys
Ser Trp Tyr Arg Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile
Asn Ala Thr Asp Pro 180 185 91188PRTHomo sapiensHuTIMP3(K45E, F57N,
K94N, E96T, R138T, G173T, R186Q, K188Q) 91Cys Thr Cys Ser Pro Ser
His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile Val Ile Arg
Ala Glu Val Val Gly Lys Lys Leu Val Lys Glu Gly 20 25 30 Pro Asn
Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 35 40 45
Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 50
55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr
Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly
Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser
Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His Leu Gly Cys Asn
Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys Phe Val Thr
Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu Ser Asn Phe
Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155 160 Cys Ile
Gln Gln Gln Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 165 170 175
Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185
92188PRTHomo sapiensHuTIMP3(K45E, F57N, K94N, E96T, R138T, G173T,
R186E) 92Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn
Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Glu Val Val Gly Lys Lys Leu
Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys
Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val
Gln Tyr Ile His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu
Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg
Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val
Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110
Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115
120 125 Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr
Asp 130 135 140 Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser Lys
His Tyr Ala 145 150 155 160 Cys Ile Glu Gln Lys Gly Gly Tyr Cys Ser
Trp Tyr Arg Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn
Ala Thr Asp Pro 180 185 93188PRTHomo sapiensHuTIMP3(K45E, F57N,
K94N, E96T, R138T, G173T, K188E) 93Cys Thr Cys Ser Pro Ser His Pro
Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Glu
Val Val Gly Lys Lys Leu Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr
Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe
Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 50 55 60
Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 65
70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu
Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln
Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys
Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser
Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu Ser Asn Phe Thr
Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155 160 Cys Ile Arg
Gln Glu Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala
165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185
94188PRTHomo sapiensHuTIMP3(K45E, F57N, K94N, E96T, R138T, G173T,
R186N, K188T) 94Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys
Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Glu Val Val Gly Lys Lys
Leu Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile
Lys Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His
Val Gln Tyr Ile His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly
Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly
Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe
Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105
110 Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr
115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp
Thr Asp 130 135 140 Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser
Lys His Tyr Ala 145 150 155 160 Cys Ile Asn Gln Thr Gly Gly Tyr Cys
Ser Trp Tyr Arg Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile
Asn Ala Thr Asp Pro 180 185 95188PRTHomo sapiensHuTIMP3(K45E, K50N,
V52T, K94N, E96T, D110N, K112T, R138T, G173T) 95Cys Thr Cys Ser Pro
Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile Val Ile
Arg Ala Glu Val Val Gly Lys Asn Leu Thr Lys Glu Gly 20 25 30 Pro
Phe Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 35 40
45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser
50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln
Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr
Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu Thr Leu
Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His Leu Gly Cys
Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys Phe Val
Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu Ser Asn
Phe Thr Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155 160 Cys
Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 165 170
175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185
96188PRTHomo sapiensHuTIMP3(K45E, K50N, V52T, K94N, E96T, R138T,
G173T, K188E) 96Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys
Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Glu Val Val Gly Lys Asn
Leu Thr Lys Glu Gly 20 25 30 Pro Phe Gly Thr Leu Val Tyr Thr Ile
Lys Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His
Val Gln Tyr Ile His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly
Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly
Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe
Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105
110 Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr
115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp
Thr Asp 130 135 140 Met Leu Ser Asn Phe Thr Tyr Pro Gly Tyr Gln Ser
Lys His Tyr Ala 145 150 155 160 Cys Ile Arg Gln Glu Gly Gly Tyr Cys
Ser Trp Tyr Arg Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile
Asn Ala Thr Asp Pro 180 185 97188PRTHomo sapiensHuTIMP3(K50N, V52T,
F57N, K94N, E96T, R138T, G173T) 97Cys Thr Cys Ser Pro Ser His Pro
Gln Asp Ala Phe Cys Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Lys
Val Val Gly Lys Asn Leu Thr Lys Glu Gly 20 25 30 Pro Asn Gly Thr
Leu Val Tyr Thr Ile Lys Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe
Thr Lys Met Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 50 55 60
Glu Ser Leu Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 65
70 75 80 Leu Thr Gly Arg Val Tyr Asp Gly Lys Met Tyr Thr Gly Leu
Cys Asn 85 90 95 Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln
Arg Lys Gly Leu 100 105 110 Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys
Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser
Lys Asn Glu Cys Leu Trp Thr Asp 130 135 140 Met Leu Ser Asn Phe Thr
Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala 145 150 155 160 Cys Ile Arg
Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 165 170 175 Pro
Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp Pro 180 185 98188PRTHomo
sapiensHuTIMP3(K50N, V52T, F57N, K94N, E96T, D110N, K112T, R138T)
98Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala Phe Cys Asn Ser Asp 1
5 10 15 Ile Val Ile Arg Ala Lys Val Val Gly Lys Asn Leu Thr Lys Glu
Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr Thr Ile Lys Gln Met Lys
Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met Pro His Val Gln Tyr Ile
His Thr Glu Ala Ser 50 55 60 Glu Ser Leu Cys Gly Leu Asn Leu Thr
Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu Thr Gly Arg Val Tyr Asn
Gly Thr Met Tyr Thr Gly Leu Cys Asn 85 90 95 Phe Val Glu Arg Trp
Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu 100 105 110 Asn Tyr Thr
Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser Cys Tyr 115 120 125 Tyr
Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys Leu Trp Thr Asp 130 135
140 Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr Gln Ser Lys His Tyr Ala
145 150 155 160 Cys Ile Arg Gln Lys Gly Gly Tyr Cys Ser Trp Tyr Arg
Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser Ile Ile Asn Ala Thr Asp
Pro 180 185 99188PRTHomo sapiensHuTIMP3(K45E, F57N, K94N, E96T,
D110N, K112T, R138T) 99Cys Thr Cys Ser Pro Ser His Pro Gln Asp Ala
Phe Cys Asn Ser Asp 1 5 10 15 Ile Val Ile Arg Ala Glu Val Val Gly
Lys Lys Leu Val Lys Glu Gly 20 25 30 Pro Asn Gly Thr Leu Val Tyr
Thr Ile Lys Gln Met Lys Met Tyr Arg 35 40 45 Gly Phe Thr Lys Met
Pro His Val Gln Tyr Ile His Thr Glu Ala Ser 50 55 60 Glu Ser Leu
Cys Gly Leu Asn Leu Thr Val Asn Lys Tyr Gln Tyr Leu 65 70 75 80 Leu
Thr Gly Arg Val Tyr Asn Gly Thr Met Tyr Thr Gly Leu Cys Asn 85 90
95 Phe Val Glu Arg Trp Asp Gln Leu Thr Leu Ser Gln Arg Lys Gly Leu
100 105 110 Asn Tyr Thr Tyr His Leu Gly Cys Asn Cys Lys Ile Lys Ser
Cys Tyr 115 120 125 Tyr Leu Pro Cys Phe Val Thr Ser Lys Asn Glu Cys
Leu Trp Thr Asp 130 135 140 Met Leu Ser Asn Phe Gly Tyr Pro Gly Tyr
Gln Ser Lys His Tyr Ala 145 150 155 160 Cys Ile Arg Gln Lys Gly Gly
Tyr Cys Ser Trp Tyr Arg Gly Trp Ala 165 170 175 Pro Pro Asp Lys Ser
Ile Ile Asn Ala Thr Asp Pro 180 185
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