U.S. patent application number 15/959054 was filed with the patent office on 2019-02-28 for uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases. The applicant listed for this patent is NGM Biopharmaceuticals, Inc.. Invention is credited to Lei Ling, Jian Luo.
Application Number | 20190060403 15/959054 |
Document ID | / |
Family ID | 51388754 |
Filed Date | 2019-02-28 |
United States Patent Application | 20190060403 |
Kind Code | A1 |
Ling; Lei ; et al. | February 28, 2019 |
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as bile acid homeostasis modulating activity, and methods for and uses in treatment of bile acid and other disorders.
Inventors: | Ling; Lei; (Foster City, CA) ; Luo; Jian; (Albany, CA) | ||||||||||
Applicant: |
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Family ID: | 51388754 | ||||||||||
Appl. No.: | 15/959054 | ||||||||||
Filed: | April 20, 2018 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
14985070 | Dec 30, 2015 | 9974833 | ||
15959054 | ||||
14141256 | Dec 26, 2013 | 9273107 | ||
14985070 | ||||
61779604 | Mar 13, 2013 | |||
61746499 | Dec 27, 2012 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | A61K 38/1825 20130101; G01N 33/68 20130101; C07K 2319/30 20130101; C07K 14/50 20130101; G01N 33/5067 20130101 |
International Class: | A61K 38/18 20060101 A61K038/18; G01N 33/50 20060101 G01N033/50; G01N 33/68 20060101 G01N033/68; C07K 14/50 20060101 C07K014/50 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 196 <210> SEQ ID NO 1 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 1 Arg Pro Leu Ala Phe Ser Asp Ala Ser Pro His
Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg Thr
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80 Met
Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85 90
95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr
100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala
Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu
Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu Pro
Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe Ser
Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu Val
Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 2 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 2 Arg
Pro Leu Ala Phe Ser Asp Ser Ser Pro Leu Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 3
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 3 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala
Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55
60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Leu Glu Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 4 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 4 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His
Val His Tyr Ala Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg Thr
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80 Met
Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85 90
95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr
100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala
Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu
Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu Pro
Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe Ser
Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu Val
Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 5 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 5 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 1 5 10
15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 6 <211> LENGTH:
187 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 6 Arg Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly
Gln Val Arg Leu Arg 1 5 10 15 His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser Ser Cys Phe Leu Arg 20 25 30 Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg Gly Gln Ser Ala His 35 40 45 Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys 50 55 60 Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met 65 70 75 80 Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu 85 90
95 Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu
100 105 110 Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys
Asn Arg 115 120 125 Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu
Pro Met Val Pro 130 135 140 Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu Ser Asp Met Phe Ser 145 150 155 160 Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe Gly Leu Val Thr Gly 165 170 175 Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 <210> SEQ ID NO 7 <211>
LENGTH: 192 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 7 Arg Pro Leu Ala Phe Ser Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly 1 5 10 15 Gln Val Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60 Thr
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65 70
75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 8 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 8 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro 1 5 10
15 Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 9 <211> LENGTH:
193 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 9 Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu
Gln Phe Gly Trp Gly 1 5 10 15 Asp Pro Ile Arg Leu Arg His Leu Tyr
Thr Ser Gly Pro His Gly Leu 20 25 30 Ser Ser Cys Phe Leu Arg Ile
Arg Ala Asp Gly Val Val Asp Cys Ala 35 40 45 Arg Gly Gln Ser Ala
His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 50 55 60 Arg Thr Val
Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 65 70 75 80 Gly
Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 85 90
95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg
100 105 110 Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys
Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser
His Phe Leu Pro 130 135 140 Met Leu Pro Met Val Pro Glu Glu Pro Glu
Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe Gly Leu Val Thr
Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185 190 Lys
<210> SEQ ID NO 10 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 10 Arg
His Pro Ile Pro Asp Ser Ser Pro His Val His Tyr Gly Trp Gly 1 5 10
15 Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu
20 25 30 Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp
Cys Ala 35 40 45 Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys
Ala Val Ala Leu 50 55 60 Arg Thr Val Ala Ile Lys Gly Val His Ser
Val Arg Tyr Leu Cys Met 65 70 75 80 Gly Ala Asp Gly Lys Met Gln Gly
Leu Leu Gln Tyr Ser Glu Glu Asp 85 90 95 Cys Ala Phe Glu Glu Glu
Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg 100 105 110 Ser Glu Lys His
Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg 115 120 125 Gln Leu
Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro 130 135 140
Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu 145
150 155 160 Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met
Asp Pro 165 170 175 Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser
Pro Ser Phe Glu 180 185 190 Lys <210> SEQ ID NO 11
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 11 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro Leu Leu Gln Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 12 <211> LENGTH: 194 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
12 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Leu Leu Gln Phe Gly Trp
1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro
His Gly 20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly
Val Val Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu
Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly
Val His Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys
Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe
Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser
Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125
Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130
135 140 Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly
His 145 150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr
Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala
Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO
13 <211> LENGTH: 192 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 13 Arg Pro Leu Ala Phe
Ser Asp Ala Gly Pro Leu Leu Gln Phe Gly Gly 1 5 10 15 Gln Val Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40
45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg
50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170
175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys
180 185 190 <210> SEQ ID NO 14 <211> LENGTH: 191
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 14 Arg His Pro Ile Pro Asp Ser Ser Pro His
Val His Tyr Gly Gly Gln 1 5 10 15 Val Arg Leu Arg His Leu Tyr Thr
Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg Ile Arg
Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser Ala His
Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60 Val Ala
Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65 70 75 80
Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85
90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser
Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln
Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His
Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu Pro Glu Asp
Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe Ser Ser Pro
Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu Val Thr Gly
Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190 <210>
SEQ ID NO 15 <211> LENGTH: 192 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 15 Arg Pro
Leu Ala Phe Ser Asp Ala Gly Pro His Val His Trp Gly Asp 1 5 10 15
Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20
25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150
155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 16 <211>
LENGTH: 192 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 16 Arg Pro Leu Ala Phe Ser Asp Ala
Gly Pro His Val His Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65
70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 17 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
17 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val Gly Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 18
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 18 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Tyr Gly Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 19 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
19 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Val Tyr Gly Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 20
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 20 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro Val His Gly Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 21 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
21 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Val His Tyr Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 22
<211> LENGTH: 193 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 22 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val His Gly Trp Gly 1 5 10 15 Asp Pro Ile Arg Leu
Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 20 25 30 Ser Ser Cys
Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 35 40 45 Arg
Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 50 55
60 Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met
65 70 75 80 Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu
Glu Asp 85 90 95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr
Asn Val Tyr Arg 100 105 110 Ser Glu Lys His Arg Leu Pro Val Ser Leu
Ser Ser Ala Lys Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg Gly Phe
Leu Pro Leu Ser His Phe Leu Pro 130 135 140 Met Leu Pro Met Val Pro
Glu Glu Pro Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp
Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe
Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185
190 Lys <210> SEQ ID NO 23 <211> LENGTH: 192
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 23 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His His Gly Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile
Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala
His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60 Thr Val
Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80
Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85
90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser
His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu Glu Pro Glu
Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly Leu Val Thr
Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 24 <211> LENGTH: 192 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 24 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His His Tyr Trp Gly Asp 1 5 10
15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140
Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145
150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 25 <211>
LENGTH: 192 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 25 Arg Pro Leu Ala Phe Ser Asp Ala
Gly Pro His Val Tyr Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65
70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 26 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
26 Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro Leu Val His Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 27
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 27 Arg Pro Leu Ala Phe Ser Asp
Ser Ser Pro His Val His Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 28 <211> LENGTH: 191 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
28 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val Trp Gly Asp Pro
1 5 10 15 Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu
Ser Ser 20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp
Cys Ala Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys
Ala Val Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser
Val Arg Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly
Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu
Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His
Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125
Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130
135 140 Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu
Ser 145 150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met
Asp Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser
Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 29
<211> LENGTH: 193 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 29 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val His Tyr Trp Gly 1 5 10 15 Asp Pro Ile Arg Leu
Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 20 25 30 Ser Ser Cys
Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 35 40 45 Arg
Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 50 55
60 Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met
65 70 75 80 Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu
Glu Asp 85 90 95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr
Asn Val Tyr Arg 100 105 110 Ser Glu Lys His Arg Leu Pro Val Ser Leu
Ser Ser Ala Lys Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg Gly Phe
Leu Pro Leu Ser His Phe Leu Pro 130 135 140 Met Leu Pro Met Val Pro
Glu Glu Pro Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp
Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe
Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185
190 Lys <210> SEQ ID NO 30 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 30 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Ala Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 31 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 31 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Ala Gln 1 5 10
15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 32 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 32 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Asp Gln 1 5 10 15 Val Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 33 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 33 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Pro Gln 1 5 10
15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 34 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 34 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Ala 1 5 10 15 Val Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 35 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 35 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Glu 1 5 10
15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 36 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 36 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Asn 1 5 10 15 Val Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 37 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 37 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 1 5 10
15 Ala Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 38 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 38 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Gln 1 5 10 15 Ile Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 39 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 39 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 1 5 10
15 Thr Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 40 <211>
LENGTH: 193 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 40 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Trp Gly 1 5 10 15 Gln Pro Val Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu 20 25 30 Ser Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 35 40 45 Arg Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 50 55 60
Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 65
70 75 80 Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu
Glu Asp 85 90 95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr
Asn Val Tyr Arg 100 105 110 Ser Glu Lys His Arg Leu Pro Val Ser Leu
Ser Ser Ala Lys Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg Gly Phe
Leu Pro Leu Ser His Phe Leu Pro 130 135 140 Met Leu Pro Met Val Pro
Glu Glu Pro Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp
Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe
Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185
190 Lys <210> SEQ ID NO 41 <211> LENGTH: 182
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 41 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Glu Pro Pro Gly Ile
Leu Ala Pro Gln Pro Pro Asp 145 150 155 160 Val Gly Ser Ser Asp Pro
Leu Ser Met Val Gly Pro Ser Gln Gly Arg 165 170 175 Ser Pro Ser Tyr
Ala Ser 180 <210> SEQ ID NO 42 <211> LENGTH: 178
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 42 His Pro Ile Pro Asp Ser Ser Pro Leu Leu
Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Leu Arg His Leu Tyr Thr Ser
Gly Pro His Gly Leu Ser Ser Cys 20 25 30 Phe Leu Arg Ile Arg Ala
Asp Gly Val Val Asp Cys Ala Arg Gly Gln 35 40 45 Ser Ala His Ser
Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 50 55 60 Ala Ile
Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 65 70 75 80
Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 85
90 95 Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu
Lys 100 105 110 His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg
Gln Leu Tyr 115 120 125 Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe
Leu Pro Met Leu Pro 130 135 140 Glu Pro Pro Gly Ile Leu Ala Pro Gln
Pro Pro Asp Val Gly Ser Ser 145 150 155 160 Asp Pro Leu Ser Met Val
Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr 165 170 175 Ala Ser
<210> SEQ ID NO 43 <211> LENGTH: 192 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 43 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Gly 1 5 10
15 Asp Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140
Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145
150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 44 <211>
LENGTH: 185 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 44 Arg Pro Leu Ala Phe Ser Asp Ala
Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Gln
Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln 20 25 30 Thr Glu Ala His
Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 35 40 45 Ala Asp
Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 50 55 60
Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 65
70 75 80 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro
Glu Ala 85 90 95 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr
Asn Val Tyr Gln 100 105 110 Ser Glu Ala His Gly Leu Pro Leu His Leu
Pro Gly Asn Lys Ser Pro 115 120 125 His Arg Asp Pro Ala Pro Arg Gly
Pro Ala Arg Phe Leu Pro Leu Pro 130 135 140 Gly Leu Pro Pro Ala Leu
Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 145 150 155 160 Pro Pro Asp
Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser 165 170 175 Gln
Gly Arg Ser Pro Ser Tyr Ala Ser 180 185 <210> SEQ ID NO 45
<211> LENGTH: 193 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 45 His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Gln Arg Tyr Leu
Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 20 25 30 Leu Glu Ile
Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 35 40 45 Pro
Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 50 55
60 Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly
65 70 75 80 Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser
Phe Arg 85 90 95 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln
Ser Glu Ala His 100 105 110 Gly Leu Pro Leu His Leu Pro Gly Asn Lys
Ser Pro His Arg Asp Pro 115 120 125 Ala Pro Arg Gly Pro Ala Arg Phe
Leu Pro Leu Pro Gly Leu Pro Pro 130 135 140 Ala Leu Pro Met Val Pro
Glu Glu Pro Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp
Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe
Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185
190 Lys <210> SEQ ID NO 46 <211> LENGTH: 232
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 46 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Gln Arg Tyr
Leu Tyr Thr Asp Asp Ala Gln Gln 20 25 30 Thr Glu Ala His Leu Glu
Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 35 40 45 Ala Asp Gln Ser
Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 50 55 60 Gly Val
Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 65 70 75 80
Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 85
90 95 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr
Gln 100 105 110 Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn
Lys Ser Pro 115 120 125 His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg
Phe Leu Pro Leu Pro 130 135 140 Gly Leu Pro Pro Ala Leu Pro Glu Pro
Pro Gly Ile Leu Ala Pro Gln 145 150 155 160 Pro Pro Asp Val Gly Ser
Ser Asp Pro Leu Ser Met Val Gly Pro Ser 165 170 175 Gln Gly Arg Ser
Pro Ser Tyr Ala Ser Pro Met Val Pro Glu Glu Pro 180 185 190 Glu Asp
Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 195 200 205
Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 210
215 220 Val Arg Ser Pro Ser Phe Glu Lys 225 230 <210> SEQ ID
NO 47 <211> LENGTH: 190 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 47 His Pro Ile Pro Asp
Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro Ile 1 5 10 15 Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 20 25 30 Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 35 40
45 Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val
50 55 60 Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
Ala Asp 65 70 75 80 Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys Ala Phe 85 90 95 Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser Glu Lys 100 105 110 His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln Leu Tyr 115 120 125 Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met Leu Pro 130 135 140 Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp 145 150 155 160 Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 165 170
175 Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 48 <211> LENGTH: 187 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
48 Arg Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Leu Arg
1 5 10 15 His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe
Leu Arg 20 25 30 Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly
Gln Ser Ala His 35 40 45 Ser Leu Leu Glu Ile Lys Ala Val Ala Leu
Arg Thr Val Ala Ile Lys 50 55 60 Gly Val His Ser Val Arg Tyr Leu
Cys Met Gly Ala Asp Gly Lys Met 65 70 75 80 Gln Gly Leu Leu Gln Tyr
Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu 85 90 95 Ile Arg Pro Asp
Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu 100 105 110 Pro Val
Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg 115 120 125
Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro 130
135 140 Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe
Ser 145 150 155 160 Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly
Leu Val Thr Gly 165 170 175 Leu Glu Ala Val Arg Ser Pro Ser Phe Glu
Lys 180 185 <210> SEQ ID NO 49 <211> LENGTH: 192
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 49 Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro
Leu Leu Gln Phe Gly Gly 1 5 10 15 Gln Val Arg Leu Arg His Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile
Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala
His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60 Thr Val
Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80
Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85
90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser
His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu Glu Pro Glu
Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly Leu Val Thr
Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 50 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 50 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Asp Gln 1 5 10
15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Leu
Glu Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 51 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 51 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Asn 1 5 10 15 Val Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 52 <211> LENGTH: 187 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 52 Arg
Asp Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro Ile Arg Leu Arg 1 5 10
15 His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg
20 25 30 Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser
Ala His 35 40 45 Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr
Val Ala Ile Lys 50 55 60 Gly Val His Ser Val Arg Tyr Leu Cys Met
Gly Ala Asp Gly Lys Met 65 70 75 80 Gln Gly Leu Leu Gln Tyr Ser Glu
Glu Asp Cys Ala Phe Glu Glu Glu 85 90 95 Ile Arg Pro Asp Gly Tyr
Asn Val Tyr Arg Ser Glu Lys His Arg Leu 100 105 110 Pro Val Ser Leu
Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg 115 120 125 Gly Phe
Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro 130 135 140
Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser 145
150 155 160 Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val
Thr Gly 165 170 175 Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180
185 <210> SEQ ID NO 53 <211> LENGTH: 189 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
53 Met Asp Ser Ser Pro Leu Val His Tyr Gly Trp Gly Asp Pro Ile Arg
1 5 10 15 Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
Cys Phe 20 25 30 Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly Gln Ser 35 40 45 Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr Val Ala 50 55 60 Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala Asp Gly 65 70 75 80 Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu 85 90 95 Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His 100 105 110 Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys 115 120 125
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met 130
135 140 Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp
Met 145 150 155 160 Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly Leu Val 165 170 175 Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 <210> SEQ ID NO 54 <211> LENGTH:
192 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 54 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
Leu Leu Gln Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile
Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala
His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60 Thr Val
Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80
Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85
90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser
His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu Glu Pro Glu
Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly Leu Val Thr
Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 55 <211> LENGTH: 192 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 55 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Tyr Gly Trp Gly Asp 1 5 10
15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140
Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145
150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 56 <211>
LENGTH: 192 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 56 Arg Pro Leu Ala Phe Ser Asp Ala
Gly Pro Val Tyr Gly Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65
70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 57 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
57 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Val His Gly Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 58
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 58 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro Val His Tyr Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 59 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
59 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His His Gly Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 60
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 60 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His His Tyr Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 61 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
61 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val Gly Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 62
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 62 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val Tyr Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 63 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
63 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 64
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 64 Arg Pro Leu Ala Phe Ser Asp
Ser Ser Pro Leu Val His Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 65 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
65 Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro His Val His Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 66
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 66 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Leu Gln Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 67 <211> LENGTH: 191 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
67 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val Trp Gly Asp Pro
1 5 10 15 Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu
Ser Ser 20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp
Cys Ala Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys
Ala Val Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser
Val Arg Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly
Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu
Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His
Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125
Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130
135 140 Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu
Ser 145 150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met
Asp Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser
Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 68
<211> LENGTH: 193 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 68 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val His Tyr Trp Gly 1 5 10 15 Asp Pro Ile Arg Leu
Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 20 25 30 Ser Ser Cys
Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 35 40 45 Arg
Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 50 55
60 Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met
65 70 75 80 Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu
Glu Asp 85 90 95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr
Asn Val Tyr Arg 100 105 110 Ser Glu Lys His Arg Leu Pro Val Ser Leu
Ser Ser Ala Lys Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg Gly Phe
Leu Pro Leu Ser His Phe Leu Pro 130 135 140 Met Leu Pro Met Val Pro
Glu Glu Pro Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp
Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe
Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185
190 Lys <210> SEQ ID NO 69 <211> LENGTH: 189
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 69 Arg Asp Ser Ser Pro Leu Val His Tyr Gly
Trp Gly Asp Pro Ile Arg 1 5 10 15 Leu Arg His Leu Tyr Thr Ser Gly
Pro His Gly Leu Ser Ser Cys Phe 20 25 30 Leu Arg Ile Arg Ala Asp
Gly Val Val Asp Cys Ala Arg Gly Gln Ser 35 40 45 Ala His Ser Leu
Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala 50 55 60 Ile Lys
Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly 65 70 75 80
Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu 85
90 95 Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys
His 100 105 110 Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln
Leu Tyr Lys 115 120 125 Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu
Pro Met Leu Pro Met 130 135 140 Val Pro Glu Glu Pro Glu Asp Leu Arg
Gly His Leu Glu Ser Asp Met 145 150 155 160 Phe Ser Ser Pro Leu Glu
Thr Asp Ser Met Asp Pro Phe Gly Leu Val 165 170 175 Thr Gly Leu Glu
Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 <210> SEQ ID NO
70 <211> LENGTH: 190 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 70 Met Arg Asp Ser Ser
Pro Leu Val His Tyr Gly Trp Gly Asp Pro Ile 1 5 10 15 Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 20 25 30 Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 35 40
45 Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val
50 55 60 Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
Ala Asp 65 70 75 80 Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys Ala Phe 85 90 95 Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser Glu Lys 100 105 110 His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln Leu Tyr 115 120 125 Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met Leu Pro 130 135 140 Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp 145 150 155 160 Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 165 170
175 Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 71 <211> LENGTH: 181 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
71 His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val
1 5 10 15 Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu
Ala His 20 25 30 Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala
Ala Asp Gln Ser 35 40 45 Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu
Lys Pro Gly Val Ile Gln 50 55 60 Ile Leu Gly Val Lys Thr Ser Arg
Phe Leu Cys Gln Arg Pro Asp Gly 65 70 75 80 Ala Leu Tyr Gly Ser Leu
His Phe Asp Pro Glu Ala Cys Ser Phe Arg 85 90 95 Glu Leu Leu Leu
Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 100 105 110 Ser Leu
Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 115 120 125
Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 130
135 140 Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp
Val 145 150 155 160 Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser
Gln Gly Arg Ser 165 170 175 Pro Ser Tyr Ala Ser 180 <210> SEQ
ID NO 72 <211> LENGTH: 181 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 72 His Pro Ile Pro Asp
Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Gln Arg
Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 20 25 30 Leu
Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 35 40
45 Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln
50 55 60 Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro
Asp Gly 65 70 75 80 Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala
Cys Ser Phe Arg 85 90 95 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val
Tyr Gln Ser Glu Ala His 100 105 110 Gly Leu Pro Leu His Leu Pro Gly
Asn Lys Ser Pro His Arg Asp Pro 115 120 125 Ala Pro Arg Gly Pro Ala
Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 130 135 140 Ala Pro Pro Glu
Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 145 150 155 160 Gly
Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 165 170
175 Pro Ser Tyr Ala Ser 180 <210> SEQ ID NO 73 <211>
LENGTH: 212 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 73 His Pro Ile Pro Asp Ser Ser Pro
Leu Leu Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Gln Arg Tyr Leu Tyr
Thr Asp Asp Ala Gln Gln Thr Glu Ala His 20 25 30 Leu Glu Ile Arg
Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 35 40 45 Pro Glu
Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 50 55 60
Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 65
70 75 80 Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser
Phe Arg 85 90 95 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln
Ser Glu Ala His 100 105 110 Gly Leu Pro Leu His Leu Pro Gly Asn Lys
Ser Pro His Arg Asp Pro 115 120 125 Ala Pro Arg Gly Pro Ala Arg Phe
Leu Pro Leu Pro Gly Leu Pro Pro 130 135 140 Ala Leu Pro Glu Pro Pro
Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 145 150 155 160 Gly Ser Ser
Asp Pro Leu Ser Met Val Val Gln Asp Glu Leu Gln Gly 165 170 175 Val
Gly Gly Glu Gly Cys His Met His Pro Glu Asn Cys Lys Thr Leu 180 185
190 Leu Thr Asp Ile Asp Arg Thr His Thr Glu Lys Pro Val Trp Asp Gly
195 200 205 Ile Thr Gly Glu 210 <210> SEQ ID NO 74
<211> LENGTH: 189 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 74 Arg Asp Ala Gly Pro His Val
His Tyr Gly Trp Gly Asp Pro Ile Arg 1 5 10 15 Leu Arg His Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe 20 25 30 Leu Arg Ile
Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser 35 40 45 Ala
His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala 50 55
60 Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly
65 70 75 80 Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala
Phe Glu 85 90 95 Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser Glu Lys His 100 105 110 Arg Leu Pro Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln Leu Tyr Lys 115 120 125 Asn Arg Gly Phe Leu Pro Leu Ser
His Phe Leu Pro Met Leu Pro Met 130 135 140 Val Pro Glu Glu Pro Glu
Asp Leu Arg Gly His Leu Glu Ser Asp Met 145 150 155 160 Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val 165 170 175 Thr
Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 <210>
SEQ ID NO 75 <211> LENGTH: 184 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 75 Arg Val
His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 1 5 10 15
Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 20
25 30 Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu
Leu 35 40 45 Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys
Gly Val His 50 55 60 Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly
Lys Met Gln Gly Leu 65 70 75 80 Leu Gln Tyr Ser Glu Glu Asp Cys Ala
Phe Glu Glu Glu Ile Arg Pro 85 90 95 Asp Gly Tyr Asn Val Tyr Arg
Ser Glu Lys His Arg Leu Pro Val Ser 100 105 110 Leu Ser Ser Ala Lys
Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 115 120 125 Pro Leu Ser
His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 130 135 140 Glu
Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 145 150
155 160 Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu
Ala 165 170 175 Val Arg Ser Pro Ser Phe Glu Lys 180 <210> SEQ
ID NO 76 <211> LENGTH: 179 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 76 Arg Gly Asp Pro Ile
Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His 1 5 10 15 Gly Leu Ser
Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp 20 25 30 Cys
Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val 35 40
45 Ala Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu
50 55 60 Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr
Ser Glu 65 70 75 80 Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp
Gly Tyr Asn Val 85 90 95 Tyr Arg Ser Glu Lys His Arg Leu Pro Val
Ser Leu Ser Ser Ala Lys 100 105 110 Gln Arg Gln Leu Tyr Lys Asn Arg
Gly Phe Leu Pro Leu Ser His Phe 115 120 125 Leu Pro Met Leu Pro Met
Val Pro Glu Glu Pro Glu Asp Leu Arg Gly 130 135 140 His Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met 145 150 155 160 Asp
Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser 165 170
175 Phe Glu Lys <210> SEQ ID NO 77 <211> LENGTH: 175
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 77 Arg Arg Leu Arg His Leu Tyr Thr Ser Gly
Pro His Gly Leu Ser Ser 1 5 10 15 Cys Phe Leu Arg Ile Arg Ala Asp
Gly Val Val Asp Cys Ala Arg Gly 20 25 30 Gln Ser Ala His Ser Leu
Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 35 40 45 Val Ala Ile Lys
Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 50 55 60 Asp Gly
Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 65 70 75 80
Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 85
90 95 Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln
Leu 100 105 110 Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu
Pro Met Leu 115 120 125 Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg
Gly His Leu Glu Ser 130 135 140 Asp Met Phe Ser Ser Pro Leu Glu Thr
Asp Ser Met Asp Pro Phe Gly 145 150 155 160 Leu Val Thr Gly Leu Glu
Ala Val Arg Ser Pro Ser Phe Glu Lys 165 170 175 <210> SEQ ID
NO 78 <211> LENGTH: 188 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 78 Arg Ala Gly Pro His
Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu 1 5 10 15 Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu 20 25 30 Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala 35 40
45 His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile
50 55 60 Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp
Gly Lys 65 70 75 80 Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys
Ala Phe Glu Glu 85 90 95 Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr
Arg Ser Glu Lys His Arg 100 105 110 Leu Pro Val Ser Leu Ser Ser Ala
Lys Gln Arg Gln Leu Tyr Lys Asn 115 120 125 Arg Gly Phe Leu Pro Leu
Ser His Phe Leu Pro Met Leu Pro Met Val 130 135 140 Pro Glu Glu Pro
Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe 145 150 155 160 Ser
Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr 165 170
175 Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
<210> SEQ ID NO 79 <211> LENGTH: 187 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 79 Arg
Gly Pro His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg 1 5 10
15 His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg
20 25 30 Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser
Ala His 35 40 45 Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr
Val Ala Ile Lys 50 55 60 Gly Val His Ser Val Arg Tyr Leu Cys Met
Gly Ala Asp Gly Lys Met 65 70 75 80 Gln Gly Leu Leu Gln Tyr Ser Glu
Glu Asp Cys Ala Phe Glu Glu Glu 85 90 95 Ile Arg Pro Asp Gly Tyr
Asn Val Tyr Arg Ser Glu Lys His Arg Leu 100 105 110 Pro Val Ser Leu
Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg 115 120 125 Gly Phe
Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro 130 135 140
Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser 145
150 155 160 Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val
Thr Gly 165 170 175 Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180
185 <210> SEQ ID NO 80 <211> LENGTH: 186 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
80 Arg Pro His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His
1 5 10 15 Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu
Arg Ile 20 25 30 Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln
Ser Ala His Ser 35 40 45 Leu Leu Glu Ile Lys Ala Val Ala Leu Arg
Thr Val Ala Ile Lys Gly 50 55 60 Val His Ser Val Arg Tyr Leu Cys
Met Gly Ala Asp Gly Lys Met Gln 65 70 75 80 Gly Leu Leu Gln Tyr Ser
Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile 85 90 95 Arg Pro Asp Gly
Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro 100 105 110 Val Ser
Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly 115 120 125
Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu 130
135 140 Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser
Ser 145 150 155 160 Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu
Val Thr Gly Leu 165 170 175 Glu Ala Val Arg Ser Pro Ser Phe Glu Lys
180 185 <210> SEQ ID NO 81 <211> LENGTH: 185
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 81 Arg His Val His Tyr Gly Trp Gly Asp Pro
Ile Arg Leu Arg His Leu 1 5 10 15 Tyr Thr Ser Gly Pro His Gly Leu
Ser Ser Cys Phe Leu Arg Ile Arg 20 25 30 Ala Asp Gly Val Val Asp
Cys Ala Arg Gly Gln Ser Ala His Ser Leu 35 40 45 Leu Glu Ile Lys
Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val 50 55 60 His Ser
Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly 65 70 75 80
Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg 85
90 95 Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro
Val 100 105 110 Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn
Arg Gly Phe 115 120 125 Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro
Met Val Pro Glu Glu 130 135 140 Pro Glu Asp Leu Arg Gly His Leu Glu
Ser Asp Met Phe Ser Ser Pro 145 150 155 160 Leu Glu Thr Asp Ser Met
Asp Pro Phe Gly Leu Val Thr Gly Leu Glu 165 170 175 Ala Val Arg Ser
Pro Ser Phe Glu Lys 180 185 <210> SEQ ID NO 82 <211>
LENGTH: 194 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 82 Arg Pro Leu Ala Phe Ser Ala Ala
Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu
Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys
Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg
Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60
Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65
70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 83 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 83 Arg Pro Leu Ala Phe Ser Asp Ala Ala Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 84 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 84 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Ala His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 85
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 85 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val His Tyr Gly Ala 1 5 10 15 Gly Asp Pro Ile Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala
Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55
60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 86 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 86 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Ala Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 87 <211> LENGTH: 167 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 87 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Ala Ile Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu
20 25 30 Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val
His Ser 35 40 45 Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met
Gln Gly Leu Leu 50 55 60 Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu
Glu Glu Ile Arg Pro Asp 65 70 75 80 Gly Tyr Asn Val Tyr Arg Ser Glu
Lys His Arg Leu Pro Val Ser Leu 85 90 95 Ser Ser Ala Lys Gln Arg
Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro 100 105 110 Leu Ser His Phe
Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu 115 120 125 Asp Leu
Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu 130 135 140
Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val 145
150 155 160 Arg Ser Pro Ser Phe Glu Lys 165 <210> SEQ ID NO
88 <211> LENGTH: 194 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 88 Arg Pro Leu Ala Phe
Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro
Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro Ala Gly 20 25 30 Leu
Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40
45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala
50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr
Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln
Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro
Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro
Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn
Arg Gly Phe Leu Pro Leu Ala His Phe Leu 130 135 140 Pro Met Leu Pro
Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu
Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170
175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe
180 185 190 Glu Lys <210> SEQ ID NO 89 <211> LENGTH:
194 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 89 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro Ala Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser Ala Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 90 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 90 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Ala Gln 115 120 125 Ala Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 91
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 91 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala
Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55
60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Ala Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ala His Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 92 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 92 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Ala Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser Ala Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 93 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 93 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Ala Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ala His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 94
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 94 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala
Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55
60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ala Ala Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 95 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 95 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Ala Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser Ala Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 96 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 96 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Ala Gln 115 120 125 Ala Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ala His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 97
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 97 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala
Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55
60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Ala Gln 115 120 125 Ala Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ser Ala Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 98 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 98 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Ala Gln 115 120 125 Ala Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ala Ala Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 99 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 99 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 100
<211> LENGTH: 181 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 100 His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Gln Arg Tyr Leu
Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 20 25 30 Leu Glu Ile
Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 35 40 45 Pro
Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 50 55
60 Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly
65 70 75 80 Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser
Phe Arg 85 90 95 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln
Ser Glu Ala His 100 105 110 Gly Leu Pro Leu His Leu Pro Gly Asn Lys
Ser Pro His Arg Asp Pro 115 120 125 Ala Pro Arg Gly Pro Ala Arg Phe
Leu Pro Leu Pro Gly Leu Pro Pro 130 135 140 Ala Leu Pro Glu Pro Pro
Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 145 150 155 160 Gly Ser Ser
Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 165 170 175 Pro
Ser Tyr Ala Ser 180 <210> SEQ ID NO 101 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 101 Val His Tyr Gly 1 <210> SEQ ID NO
102 <211> LENGTH: 9 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 102 Asp Ala Ser Pro
His Val His Tyr Gly 1 5 <210> SEQ ID NO 103 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 103 Asp Ser Ser Pro Leu Val His Tyr Gly 1 5
<210> SEQ ID NO 104 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 104
Asp Ser Ser Pro Leu Leu Gln 1 5 <210> SEQ ID NO 105
<211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 105 Asp Ser Ser Pro Leu Leu Gln
Phe Gly Gly Gln Val 1 5 10 <210> SEQ ID NO 106 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 106 Arg His Pro Ile Pro 1 5 <210> SEQ
ID NO 107 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 107 His Pro Ile Pro 1
<210> SEQ ID NO 108 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 108
Arg Pro Leu Ala Phe 1 5 <210> SEQ ID NO 109 <211>
LENGTH: 4 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 109 Pro Leu Ala Phe 1 <210> SEQ ID NO
110 <211> LENGTH: 6 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 110 Met Asp Ser Ser
Pro Leu 1 5 <210> SEQ ID NO 111 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 111 Met Ser Asp Ser Ser Pro Leu 1 5
<210> SEQ ID NO 112 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 112
Ser Asp Ser Ser Pro Leu 1 5 <210> SEQ ID NO 113 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 113 Met Ser Ser Pro Leu 1 5 <210> SEQ
ID NO 114 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 114 Ser Ser Pro Leu 1
<210> SEQ ID NO 115 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 115
Arg Asp Ser Ser 1 <210> SEQ ID NO 116 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 116 Met Asp Ser Ser 1 <210> SEQ ID NO
117 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 117 Met Arg Asp Ser
Ser 1 5 <210> SEQ ID NO 118 <211> LENGTH: 5 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
118 Met Ser Ser Pro Leu 1 5 <210> SEQ ID NO 119 <211>
LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 119 Met Asp Ser Ser Pro Leu 1 5 <210>
SEQ ID NO 120 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 120 Met
Ser Asp Ser Ser Pro Leu 1 5 <210> SEQ ID NO 121 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 121 Asp Ser Ser Pro Leu 1 5 <210> SEQ
ID NO 122 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 122 Asp Ala Ser Pro
His 1 5 <210> SEQ ID NO 123 <211> LENGTH: 4 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
123 Arg Asp Ser Ser 1 <210> SEQ ID NO 124 <211> LENGTH:
4 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 124 Met Asp Ser Ser 1 <210> SEQ ID NO
125 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 125 Met Arg Asp Ser
Ser 1 5 <210> SEQ ID NO 126 <211> LENGTH: 6 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
126 Met Asp Ser Ser Pro Leu 1 5 <210> SEQ ID NO 127
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 127 Met Ser Asp Ser Ser Pro Leu
1 5 <210> SEQ ID NO 128 <211> LENGTH: 5 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
128 Met Ser Ser Pro Leu 1 5 <210> SEQ ID NO 129 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Description of Artificial Sequence: Linker sequence <400>
SEQUENCE: 129 Gly Ser Gly Gly Ser 1 5 <210> SEQ ID NO 130
<211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Description of Artificial Sequence: Linker sequence
<400> SEQUENCE: 130 Gly Gly Gly Ser 1 <210> SEQ ID NO
131 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Description of Artificial Sequence: Linker
sequence <400> SEQUENCE: 131 Gly Gly Ser Gly 1 <210>
SEQ ID NO 132 <211> LENGTH: 5 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Linker sequence <400> SEQUENCE: 132 Gly Gly Ser Gly Gly 1 5
<210> SEQ ID NO 133 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Linker sequence <400> SEQUENCE: 133 Gly Ser Gly Ser Gly 1 5
<210> SEQ ID NO 134 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Linker sequence <400> SEQUENCE: 134 Gly Ser Gly Gly Gly 1 5
<210> SEQ ID NO 135 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Linker sequence <400> SEQUENCE: 135 Gly Ser Ser Ser Gly 1 5
<210> SEQ ID NO 136 <211> LENGTH: 32 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Forward primer <400> SEQUENCE: 136 ccgactagtc accatgcgga
gcgggtgtgt gg 32 <210> SEQ ID NO 137 <211> LENGTH: 41
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Reverse primer <400> SEQUENCE: 137
ataagaatgc ggccgcttac ttctcaaagc tgggactcct c 41 <210> SEQ ID
NO 138 <211> LENGTH: 186 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 138 Asp Ser Ser Pro
Leu Leu Gln Phe Gly Gly Gln Val Arg Leu Arg His 1 5 10 15 Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile 20 25 30
Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser 35
40 45 Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys
Gly 50 55 60 Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly
Lys Met Gln 65 70 75 80 Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala
Phe Glu Glu Glu Ile 85 90 95 Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser Glu Lys His Arg Leu Pro 100 105 110 Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln Leu Tyr Lys Asn Arg Gly 115 120 125 Phe Leu Pro Leu Ser
His Phe Leu Pro Met Leu Pro Met Val Pro Glu 130 135 140 Glu Pro Glu
Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser 145 150 155 160
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu 165
170 175 Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 <210>
SEQ ID NO 139 <211> LENGTH: 194 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 139 Arg
Pro Leu Ala Phe Ser Asp Ala Ser Pro His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 140
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 140 Arg Pro Leu Ala Phe Ser Asp
Ser Ser Pro Leu Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala
Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55
60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 141 <211> LENGTH: 188
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 141 Asp Ser Ser Pro Leu Val His Tyr Gly Trp
Gly Asp Pro Ile Arg Leu 1 5 10 15 Arg His Leu Tyr Thr Ser Gly Pro
His Gly Leu Ser Ser Cys Phe Leu 20 25 30 Arg Ile Arg Ala Asp Gly
Val Val Asp Cys Ala Arg Gly Gln Ser Ala 35 40 45 His Ser Leu Leu
Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile 50 55 60 Lys Gly
Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys 65 70 75 80
Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu 85
90 95 Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His
Arg 100 105 110 Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu
Tyr Lys Asn 115 120 125 Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro
Met Leu Pro Met Val 130 135 140 Pro Glu Glu Pro Glu Asp Leu Arg Gly
His Leu Glu Ser Asp Met Phe 145 150 155 160 Ser Ser Pro Leu Glu Thr
Asp Ser Met Asp Pro Phe Gly Leu Val Thr 165 170 175 Gly Leu Glu Ala
Val Arg Ser Pro Ser Phe Glu Lys 180 185 <210> SEQ ID NO 142
<211> LENGTH: 193 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 142 Arg His Pro Ile Pro Asp Ser
Ser Pro Leu Leu Gln Phe Gly Trp Gly 1 5 10 15 Asp Pro Ile Arg Leu
Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 20 25 30 Ser Ser Cys
Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 35 40 45 Arg
Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 50 55
60 Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met
65 70 75 80 Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu
Glu Asp 85 90 95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr
Asn Val Tyr Arg 100 105 110 Ser Glu Lys His Arg Leu Pro Val Ser Leu
Ser Ser Ala Lys Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg Gly Phe
Leu Pro Leu Ser His Phe Leu Pro 130 135 140 Met Leu Pro Met Val Pro
Glu Glu Pro Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp
Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe
Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185
190 Lys <210> SEQ ID NO 143 <211> LENGTH: 191
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 143 Arg His Pro Ile Pro Asp Ser Ser Pro Leu
Leu Gln Trp Gly Asp Pro 1 5 10 15 Ile Arg Leu Arg His Leu Tyr Thr
Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg Ile Arg
Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser Ala His
Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60 Val Ala
Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65 70 75 80
Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85
90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser
Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln
Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His
Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu Pro Glu Asp
Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe Ser Ser Pro
Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu Val Thr Gly
Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190 <210>
SEQ ID NO 144 <211> LENGTH: 194 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 144 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro Leu Leu Gln Phe Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 145
<211> LENGTH: 193 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 145 Arg His Pro Ile Pro Asp Ser
Ser Pro His Val His Tyr Gly Trp Gly 1 5 10 15 Asp Pro Ile Arg Leu
Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 20 25 30 Ser Ser Cys
Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 35 40 45 Arg
Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 50 55
60 Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met
65 70 75 80 Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu
Glu Asp 85 90 95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr
Asn Val Tyr Arg 100 105 110 Ser Glu Lys His Arg Leu Pro Val Ser Leu
Ser Ser Ala Lys Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg Gly Phe
Leu Pro Leu Ser His Phe Leu Pro 130 135 140 Met Leu Pro Met Val Pro
Glu Glu Pro Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp
Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe
Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185
190 Lys <210> SEQ ID NO 146 <211> LENGTH: 192
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 146 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
Leu Leu Gln Phe Gly Gly 1 5 10 15 Gln Val Arg Leu Arg His Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile
Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala
His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60 Thr Val
Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80
Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85
90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser
His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu Glu Pro Glu
Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly Leu Val Thr
Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 147 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 147
Arg His Pro Ile Pro Asp Ser Ser Pro His Val His Tyr Gly Gly Gln 1 5
10 15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
Ser 20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135
140 Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser
145 150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 148 <211>
LENGTH: 187 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 148 Arg Asp Ser Ser Pro Leu Leu Gln
Phe Gly Gly Gln Val Arg Leu Arg 1 5 10 15 His Leu Tyr Thr Ser Gly
Pro His Gly Leu Ser Ser Cys Phe Leu Arg 20 25 30 Ile Arg Ala Asp
Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His 35 40 45 Ser Leu
Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys 50 55 60
Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met 65
70 75 80 Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu
Glu Glu 85 90 95 Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu
Lys His Arg Leu 100 105 110 Pro Val Ser Leu Ser Ser Ala Lys Gln Arg
Gln Leu Tyr Lys Asn Arg 115 120 125 Gly Phe Leu Pro Leu Ser His Phe
Leu Pro Met Leu Pro Met Val Pro 130 135 140 Glu Glu Pro Glu Asp Leu
Arg Gly His Leu Glu Ser Asp Met Phe Ser 145 150 155 160 Ser Pro Leu
Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly 165 170 175 Leu
Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 <210> SEQ ID
NO 149 <211> LENGTH: 192 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 149 Arg Pro Leu Ala
Phe Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 1 5 10 15 Gln Val
Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30
Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35
40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu
Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu
Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr
Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp
Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val
Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg
Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met
Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160
Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165
170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu
Lys 180 185 190 <210> SEQ ID NO 150 <211> LENGTH: 191
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 150 Arg His Pro Ile Pro Asp Ser Ser Pro Leu
Leu Gln Phe Gly Ala Gln 1 5 10 15 Val Arg Leu Arg His Leu Tyr Thr
Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg Ile Arg
Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser Ala His
Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60 Val Ala
Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65 70 75 80
Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85
90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser
Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln
Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His
Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu Pro Glu Asp
Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe Ser Ser Pro
Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu Val Thr Gly
Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190 <210>
SEQ ID NO 151 <211> LENGTH: 191 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 151 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Asp Gln 1 5 10
15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 152 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 152 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Pro Gln 1 5 10 15 Val Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 153 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 153
Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Ala 1 5
10 15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
Ser 20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135
140 Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser
145 150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 154 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 154 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Glu 1 5 10 15 Val Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 155 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 155
Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Asn 1 5
10 15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
Ser 20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135
140 Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser
145 150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 156 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 156 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Gln 1 5 10 15 Ala Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 157 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 157
Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 1 5
10 15 Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
Ser 20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135
140 Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser
145 150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 158 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 158 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Gln 1 5 10 15 Thr Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 159 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 159
Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Trp Gly 1 5
10 15 Gln Pro Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu 20 25 30 Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala 35 40 45 Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu 50 55 60 Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met 65 70 75 80 Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp 85 90 95 Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg 100 105 110 Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg 115 120 125 Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro 130 135
140 Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
145 150 155 160 Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro 165 170 175 Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu 180 185 190 Lys <210> SEQ ID NO 160
<211> LENGTH: 190 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 160 His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 20 25 30 Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 35 40 45 Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 50 55
60 Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp
65 70 75 80 Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys
Ala Phe 85 90 95 Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr
Arg Ser Glu Lys 100 105 110 His Arg Leu Pro Val Ser Leu Ser Ser Ala
Lys Gln Arg Gln Leu Tyr 115 120 125 Lys Asn Arg Gly Phe Leu Pro Leu
Ser His Phe Leu Pro Met Leu Pro 130 135 140 Met Val Pro Glu Glu Pro
Glu Asp Leu Arg Gly His Leu Glu Ser Asp 145 150 155 160 Met Phe Ser
Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 165 170 175 Val
Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 161 <211> LENGTH: 186 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 161
Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Leu Arg His 1 5
10 15 Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg
Ile 20 25 30 Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser
Ala His Ser 35 40 45 Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr
Val Ala Ile Lys Gly 50 55 60 Val His Ser Val Arg Tyr Leu Cys Met
Gly Ala Asp Gly Lys Met Gln 65 70 75 80 Gly Leu Leu Gln Tyr Ser Glu
Glu Asp Cys Ala Phe Glu Glu Glu Ile 85 90 95 Arg Pro Asp Gly Tyr
Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro 100 105 110 Val Ser Leu
Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly 115 120 125 Phe
Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu 130 135
140 Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser
145 150 155 160 Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val
Thr Gly Leu 165 170 175 Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180
185 <210> SEQ ID NO 162 <211> LENGTH: 190 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
162 His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro Ile
1 5 10 15 Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
Ser Cys 20 25 30 Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg Gly Gln 35 40 45 Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg Thr Val 50 55 60 Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly Ala Asp 65 70 75 80 Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 85 90 95 Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 100 105 110 His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 115 120 125
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro 130
135 140 Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser
Asp 145 150 155 160 Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe Gly Leu 165 170 175 Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 163 <211>
LENGTH: 192 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 163 His Pro Ile Pro Asp Ser Ser Pro
Leu Leu Gln Phe Gly Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65
70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 164 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
164 His Pro Ile Pro Asp Ser Ser Pro His Val His Tyr Gly Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 165
<211> LENGTH: 190 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 165 His Pro Ile Pro Asp Ser Ser
Pro His Val His Tyr Gly Gly Gln Val 1 5 10 15 Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 20 25 30 Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 35 40 45 Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 50 55
60 Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp
65 70 75 80 Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys
Ala Phe 85 90 95 Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr
Arg Ser Glu Lys 100 105 110 His Arg Leu Pro Val Ser Leu Ser Ser Ala
Lys Gln Arg Gln Leu Tyr 115 120 125 Lys Asn Arg Gly Phe Leu Pro Leu
Ser His Phe Leu Pro Met Leu Pro 130 135 140 Met Val Pro Glu Glu Pro
Glu Asp Leu Arg Gly His Leu Glu Ser Asp 145 150 155 160 Met Phe Ser
Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 165 170 175 Val
Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 166 <211> LENGTH: 188 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 166
Asp Ala Gly Pro His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu 1 5
10 15 Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe
Leu 20 25 30 Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly
Gln Ser Ala 35 40 45 His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu
Arg Thr Val Ala Ile 50 55 60 Lys Gly Val His Ser Val Arg Tyr Leu
Cys Met Gly Ala Asp Gly Lys 65 70 75 80 Met Gln Gly Leu Leu Gln Tyr
Ser Glu Glu Asp Cys Ala Phe Glu Glu 85 90 95 Glu Ile Arg Pro Asp
Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg 100 105 110 Leu Pro Val
Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn 115 120 125 Arg
Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val 130 135
140 Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe
145 150 155 160 Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly
Leu Val Thr 165 170 175 Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu
Lys 180 185 <210> SEQ ID NO 167 <211> LENGTH: 183
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 167 Val His Tyr Gly Trp Gly Asp Pro Ile Arg
Leu Arg His Leu Tyr Thr 1 5 10 15 Ser Gly Pro His Gly Leu Ser Ser
Cys Phe Leu Arg Ile Arg Ala Asp 20 25 30 Gly Val Val Asp Cys Ala
Arg Gly Gln Ser Ala His Ser Leu Leu Glu 35 40 45 Ile Lys Ala Val
Ala Leu Arg Thr Val Ala Ile Lys Gly Val His Ser 50 55 60 Val Arg
Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu 65 70 75 80
Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp 85
90 95 Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu 100 105 110 Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro 115 120 125 Leu Ser His Phe Leu Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu 130 135 140 Asp Leu Arg Gly His Leu Glu Ser Asp
Met Phe Ser Ser Pro Leu Glu 145 150 155 160 Thr Asp Ser Met Asp Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val 165 170 175 Arg Ser Pro Ser
Phe Glu Lys 180 <210> SEQ ID NO 168 <211> LENGTH: 174
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 168 Arg Leu Arg His Leu Tyr Thr Ser Gly Pro
His Gly Leu Ser Ser Cys 1 5 10 15 Phe Leu Arg Ile Arg Ala Asp Gly
Val Val Asp Cys Ala Arg Gly Gln 20 25 30 Ser Ala His Ser Leu Leu
Glu Ile Lys Ala Val Ala Leu Arg Thr Val 35 40 45 Ala Ile Lys Gly
Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 50 55 60 Gly Lys
Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 65 70 75 80
Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 85
90 95 His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu
Tyr 100 105 110 Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro
Met Leu Pro 115 120 125 Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly
His Leu Glu Ser Asp 130 135 140 Met Phe Ser Ser Pro Leu Glu Thr Asp
Ser Met Asp Pro Phe Gly Leu 145 150 155 160 Val Thr Gly Leu Glu Ala
Val Arg Ser Pro Ser Phe Glu Lys 165 170 <210> SEQ ID NO 169
<211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 169 Trp Gly
Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly 1 5 10 <210>
SEQ ID NO 170 <211> LENGTH: 5 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 170 Trp Gly Asp Pro Ile 1 5 <210> SEQ ID NO 171
<211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 171 Trp Gly
Pro Ile 1 <210> SEQ ID NO 172 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 172 Trp Gly Asp Pro Val 1 5
<210> SEQ ID NO 173 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 173 Trp Gly Asp Ile 1 <210> SEQ ID NO 174
<211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 174 Gly Asp
Pro Ile 1 <210> SEQ ID NO 175 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 175 Trp Gly Gln Pro Ile 1 5
<210> SEQ ID NO 176 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 176 Trp Gly Ala Pro Ile 1 5 <210> SEQ ID NO 177
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 177 Ala Gly
Asp Pro Ile 1 5 <210> SEQ ID NO 178 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 178 Trp Ala Asp Pro Ile 1 5
<210> SEQ ID NO 179 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 179 Trp Gly Asp Ala Ile 1 5 <210> SEQ ID NO 180
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 180 Trp Gly
Asp Pro Ala 1 5 <210> SEQ ID NO 181 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 181 Trp Asp Pro Ile 1 <210> SEQ
ID NO 182 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 182 Trp
Gly Asp Ile 1 <210> SEQ ID NO 183 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 183 Trp Gly Asp Pro 1 <210> SEQ
ID NO 184 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 184 Phe
Gly Asp Pro Ile 1 5 <210> SEQ ID NO 185 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 185 Arg Leu Arg His Leu Tyr Thr Ser
Gly 1 5 <210> SEQ ID NO 186 <211> LENGTH: 9 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: core sequence <400>
SEQUENCE: 186 Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 1 5 <210>
SEQ ID NO 187 <211> LENGTH: 13 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 187 Ala Gly Pro His Val His Tyr Gly Trp Gly Asp Pro Ile 1
5 10 <210> SEQ ID NO 188 <211> LENGTH: 165 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<223> OTHER INFORMATION: FGF19 C-terminal sequence
<400> SEQUENCE: 188 Pro His Gly Leu Ser Ser Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val 1 5 10 15 Val Asp Cys Ala Arg Gly Gln Ser
Ala His Ser Leu Leu Glu Ile Lys 20 25 30 Ala Val Ala Leu Arg Thr
Val Ala Ile Lys Gly Val His Ser Val Arg 35 40 45 Tyr Leu Cys Met
Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr 50 55 60 Ser Glu
Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr 65 70 75 80
Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser 85
90 95 Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu
Ser 100 105 110 His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro
Glu Asp Leu 115 120 125 Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp 130 135 140 Ser Met Asp Pro Phe Gly Leu Val Thr
Gly Leu Glu Ala Val Arg Ser 145 150 155 160 Pro Ser Phe Glu Lys 165
<210> SEQ ID NO 189 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Linker sequence <400>
SEQUENCE: 189 Gly Gly Gly Ser Gly 1 5 <210> SEQ ID NO 190
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <223> OTHER INFORMATION:
Sheet-8/Loop-8/Sheet-9 region of FGF19 <400> SEQUENCE: 190
Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 1 5 10 <210> SEQ
ID NO 191 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <220> FEATURE: <223> OTHER
INFORMATION: Sheet-8/Loop-8/Sheet-9 region of FGF21 <400>
SEQUENCE: 191 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 1 5 10
<210> SEQ ID NO 192 <211> LENGTH: 187 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: M53 sequence <400> SEQUENCE:
192 Met Asp Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro Ile Arg Leu Arg
1 5 10 15 His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe
Leu Arg 20 25 30 Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly
Gln Ser Ala His 35 40 45 Ser Leu Leu Glu Ile Lys Ala Val Ala Leu
Arg Thr Val Ala Ile Lys 50 55 60 Gly Val His Ser Val Arg Tyr Leu
Cys Met Gly Ala Asp Gly Lys Met 65 70 75 80 Gln Gly Leu Leu Gln Tyr
Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu 85 90 95 Ile Arg Pro Asp
Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu 100 105 110 Pro Val
Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg 115 120 125
Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro 130
135 140 Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe
Ser 145 150 155 160 Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly
Leu Val Thr Gly 165 170 175 Leu Glu Ala Val Arg Ser Pro Ser Phe Glu
Lys 180 185 <210> SEQ ID NO 193 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: M139 sequence
<400> SEQUENCE: 193 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Leu Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 194 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: M140 sequence <400> SEQUENCE:
194 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp
1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro
His Gly 20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly
Val Val Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu
Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly
Val His Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys
Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe
Glu Glu Glu Ile Arg Glu Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser
Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125
Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130
135 140 Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly
His 145 150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr
Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala
Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO
195 <211> LENGTH: 194 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: M141 sequence <400> SEQUENCE: 195 Arg Pro
Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15
Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20
25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp
Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys
Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser
Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly
Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu
Ile Leu Cys Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His
Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu
Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140 Pro
Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150
155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met
Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser
Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 196
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: M160 sequence <400> SEQUENCE: 196 Arg Pro Leu
Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly
Asp Pro Ile Arg Gln Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25
30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile
Leu Glu Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140 Pro Met
Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155
160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe 180 185 190 Glu Lys
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 196
<210> SEQ ID NO 1 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 1 Arg
Pro Leu Ala Phe Ser Asp Ala Ser Pro His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 2
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 2 Arg Pro Leu Ala Phe Ser Asp
Ser Ser Pro Leu Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala
Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55
60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 3 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 3 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His
Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg Thr
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80 Met
Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85 90
95 Asp Cys Ala Phe Glu Glu Glu Ile Leu Glu Asp Gly Tyr Asn Val Tyr
100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala
Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu
Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu Pro
Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe Ser
Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu Val
Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 4 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 4 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Ala Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 5
<211> LENGTH: 191 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 5 Arg His Pro Ile Pro Asp Ser
Ser Pro Leu Leu Gln Phe Gly Gly Gln 1 5 10 15 Val Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55
60 Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala
65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 6 <211> LENGTH: 187 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 6 Arg
Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Leu Arg 1 5 10
15 His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg
20 25 30 Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser
Ala His 35 40 45 Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr
Val Ala Ile Lys
50 55 60 Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly
Lys Met 65 70 75 80 Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala
Phe Glu Glu Glu 85 90 95 Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser Glu Lys His Arg Leu 100 105 110 Pro Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln Leu Tyr Lys Asn Arg 115 120 125 Gly Phe Leu Pro Leu Ser
His Phe Leu Pro Met Leu Pro Met Val Pro 130 135 140 Glu Glu Pro Glu
Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser 145 150 155 160 Ser
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly 165 170
175 Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 <210>
SEQ ID NO 7 <211> LENGTH: 192 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 7 Arg Pro
Leu Ala Phe Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 1 5 10 15
Gln Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20
25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150
155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 8 <211> LENGTH:
191 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 8 Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu
Gln Trp Gly Asp Pro 1 5 10 15 Ile Arg Leu Arg His Leu Tyr Thr Ser
Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg Ile Arg Ala
Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser Ala His Ser
Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60 Val Ala Ile
Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp
Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85 90
95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu
100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg
Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe
Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu Pro Glu Asp Leu
Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe Ser Ser Pro Leu
Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu
Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ
ID NO 9 <211> LENGTH: 193 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 9 Arg His Pro Ile Pro
Asp Ser Ser Pro Leu Leu Gln Phe Gly Trp Gly 1 5 10 15 Asp Pro Ile
Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 20 25 30 Ser
Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 35 40
45 Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu
50 55 60 Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu
Cys Met 65 70 75 80 Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr
Ser Glu Glu Asp 85 90 95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp
Gly Tyr Asn Val Tyr Arg 100 105 110 Ser Glu Lys His Arg Leu Pro Val
Ser Leu Ser Ser Ala Lys Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg
Gly Phe Leu Pro Leu Ser His Phe Leu Pro 130 135 140 Met Leu Pro Met
Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu
Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170
175 Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu
180 185 190 Lys <210> SEQ ID NO 10 <211> LENGTH: 193
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 10 Arg His Pro Ile Pro Asp Ser Ser Pro His
Val His Tyr Gly Trp Gly 1 5 10 15 Asp Pro Ile Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu 20 25 30 Ser Ser Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala 35 40 45 Arg Gly Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 50 55 60 Arg Thr
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 65 70 75 80
Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 85
90 95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr
Arg 100 105 110 Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala
Lys Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu
Ser His Phe Leu Pro 130 135 140 Met Leu Pro Met Val Pro Glu Glu Pro
Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp Met Phe Ser
Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe Gly Leu Val
Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185 190 Lys
<210> SEQ ID NO 11 <211> LENGTH: 192 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 11 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro Leu Leu Gln Trp Gly Asp 1 5 10
15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140
Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145
150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 12 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 12 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro Leu Leu Gln Phe Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 13
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 13 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro Leu Leu Gln Phe Gly Gly 1 5 10 15 Gln Val Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 14 <211> LENGTH: 191 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
14 Arg His Pro Ile Pro Asp Ser Ser Pro His Val His Tyr Gly Gly Gln
1 5 10 15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu
Ser Ser 20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp
Cys Ala Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys
Ala Val Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser
Val Arg Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly
Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu
Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His
Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125
Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130
135 140 Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu
Ser 145 150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met
Asp Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser
Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 15
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 15 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val His Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 16 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
16 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 17
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 17 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val Gly Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln
115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu
Pro Met 130 135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg
Gly His Leu Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu
Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu
Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID
NO 18 <211> LENGTH: 192 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 18 Arg Pro Leu Ala Phe
Ser Asp Ala Gly Pro His Tyr Gly Trp Gly Asp 1 5 10 15 Pro Ile Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40
45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg
50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170
175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys
180 185 190 <210> SEQ ID NO 19 <211> LENGTH: 192
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 19 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
Val Tyr Gly Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile
Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala
His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60 Thr Val
Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80
Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85
90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser
His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu Glu Pro Glu
Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly Leu Val Thr
Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 20 <211> LENGTH: 192 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 20 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro Val His Gly Trp Gly Asp 1 5 10
15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140
Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145
150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 21 <211>
LENGTH: 192 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 21 Arg Pro Leu Ala Phe Ser Asp Ala
Gly Pro Val His Tyr Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65
70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 22 <211> LENGTH: 193 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
22 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Gly Trp Gly
1 5 10 15 Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His
Gly Leu 20 25 30 Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val
Val Asp Cys Ala 35 40 45 Arg Gly Gln Ser Ala His Ser Leu Leu Glu
Ile Lys Ala Val Ala Leu 50 55 60 Arg Thr Val Ala Ile Lys Gly Val
His Ser Val Arg Tyr Leu Cys Met 65 70 75 80 Gly Ala Asp Gly Lys Met
Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 85 90 95 Cys Ala Phe Glu
Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg 100 105 110 Ser Glu
Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg 115 120 125
Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro 130
135 140 Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His
Leu 145 150 155 160 Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp
Ser Met Asp Pro 165 170 175 Phe Gly Leu Val Thr Gly Leu Glu Ala Val
Arg Ser Pro Ser Phe Glu 180 185 190 Lys <210> SEQ ID NO 23
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 23 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His His Gly Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg
35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala
Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr
Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln
Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro
Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro
Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn
Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro
Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155
160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe
165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe
Glu Lys 180 185 190 <210> SEQ ID NO 24 <211> LENGTH:
192 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 24 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His His Tyr Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile
Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala
His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60 Thr Val
Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80
Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85
90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser
His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu Glu Pro Glu
Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly Leu Val Thr
Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 25 <211> LENGTH: 192 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 25 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val Tyr Trp Gly Asp 1 5 10
15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140
Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145
150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 26 <211>
LENGTH: 192 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 26 Arg Pro Leu Ala Phe Ser Asp Ser
Ser Pro Leu Val His Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65
70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 27 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
27 Arg Pro Leu Ala Phe Ser Asp Ser Ser Pro His Val His Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 28
<211> LENGTH: 191 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 28 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val Trp Gly Asp Pro 1 5 10 15 Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55
60 Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala
65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 29
<211> LENGTH: 193 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 29 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val His Tyr Trp Gly 1 5 10 15 Asp Pro Ile Arg Leu
Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu 20 25 30 Ser Ser Cys
Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 35 40 45 Arg
Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 50 55
60 Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met
65 70 75 80 Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu
Glu Asp 85 90 95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr
Asn Val Tyr Arg 100 105 110 Ser Glu Lys His Arg Leu Pro Val Ser Leu
Ser Ser Ala Lys Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg Gly Phe
Leu Pro Leu Ser His Phe Leu Pro 130 135 140 Met Leu Pro Met Val Pro
Glu Glu Pro Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp
Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe
Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185
190 Lys <210> SEQ ID NO 30 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 30 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Ala Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 31 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 31 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Ala Gln 1 5 10
15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 32 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 32 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Asp Gln 1 5 10 15 Val Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 33 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 33 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Pro Gln 1 5 10
15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 34 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 34 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Ala 1 5 10 15 Val Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110
Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115
120 125 Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met
Leu 130 135 140 Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His
Leu Glu Ser 145 150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp
Ser Met Asp Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val
Arg Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 35
<211> LENGTH: 191 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 35 Arg His Pro Ile Pro Asp Ser
Ser Pro Leu Leu Gln Phe Gly Gly Glu 1 5 10 15 Val Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55
60 Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala
65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 36 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 36 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Asn 1 5 10
15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 37 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 37 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Gln 1 5 10 15 Ala Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 38 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 38 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 1 5 10
15 Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 39 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 39 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Gln 1 5 10 15 Thr Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 40 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 40 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Trp Gly 1 5 10
15 Gln Pro Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu
20 25 30 Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp
Cys Ala 35 40 45
Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 50
55 60 Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
Met 65 70 75 80 Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu Asp 85 90 95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr Arg 100 105 110 Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Lys Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ser His Phe Leu Pro 130 135 140 Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180
185 190 Lys <210> SEQ ID NO 41 <211> LENGTH: 182
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 41 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Glu Pro Pro Gly Ile
Leu Ala Pro Gln Pro Pro Asp 145 150 155 160 Val Gly Ser Ser Asp Pro
Leu Ser Met Val Gly Pro Ser Gln Gly Arg 165 170 175 Ser Pro Ser Tyr
Ala Ser 180 <210> SEQ ID NO 42 <211> LENGTH: 178
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 42 His Pro Ile Pro Asp Ser Ser Pro Leu Leu
Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Leu Arg His Leu Tyr Thr Ser
Gly Pro His Gly Leu Ser Ser Cys 20 25 30 Phe Leu Arg Ile Arg Ala
Asp Gly Val Val Asp Cys Ala Arg Gly Gln 35 40 45 Ser Ala His Ser
Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 50 55 60 Ala Ile
Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 65 70 75 80
Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 85
90 95 Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu
Lys 100 105 110 His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg
Gln Leu Tyr 115 120 125 Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe
Leu Pro Met Leu Pro 130 135 140 Glu Pro Pro Gly Ile Leu Ala Pro Gln
Pro Pro Asp Val Gly Ser Ser 145 150 155 160 Asp Pro Leu Ser Met Val
Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr 165 170 175 Ala Ser
<210> SEQ ID NO 43 <211> LENGTH: 192 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 43 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Gly 1 5 10
15 Asp Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140
Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145
150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 44 <211>
LENGTH: 185 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 44 Arg Pro Leu Ala Phe Ser Asp Ala
Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Gln
Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln 20 25 30 Thr Glu Ala His
Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 35 40 45 Ala Asp
Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 50 55 60
Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 65
70 75 80 Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro
Glu Ala 85 90 95 Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr
Asn Val Tyr Gln 100 105 110 Ser Glu Ala His Gly Leu Pro Leu His Leu
Pro Gly Asn Lys Ser Pro 115 120 125 His Arg Asp Pro Ala Pro Arg Gly
Pro Ala Arg Phe Leu Pro Leu Pro 130 135 140 Gly Leu Pro Pro Ala Leu
Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 145 150 155 160 Pro Pro Asp
Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser 165 170 175 Gln
Gly Arg Ser Pro Ser Tyr Ala Ser 180 185 <210> SEQ ID NO 45
<211> LENGTH: 193 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 45 His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Gln Arg Tyr Leu
Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 20 25 30 Leu Glu Ile
Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 35 40 45 Pro
Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 50 55
60 Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly
65 70 75 80 Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser
Phe Arg 85 90 95 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln
Ser Glu Ala His 100 105 110 Gly Leu Pro Leu His Leu Pro Gly Asn Lys
Ser Pro His Arg Asp Pro 115 120 125 Ala Pro Arg Gly Pro Ala Arg Phe
Leu Pro Leu Pro Gly Leu Pro Pro 130 135 140 Ala Leu Pro Met Val Pro
Glu Glu Pro Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp
Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe
Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185
190 Lys
<210> SEQ ID NO 46 <211> LENGTH: 232 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 46 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln
20 25 30 Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly
Gly Ala 35 40 45 Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys
Ala Leu Lys Pro 50 55 60 Gly Val Ile Gln Ile Leu Gly Val Lys Thr
Ser Arg Phe Leu Cys Gln 65 70 75 80 Arg Pro Asp Gly Ala Leu Tyr Gly
Ser Leu His Phe Asp Pro Glu Ala 85 90 95 Cys Ser Phe Arg Glu Leu
Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 100 105 110 Ser Glu Ala His
Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro 115 120 125 His Arg
Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 130 135 140
Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 145
150 155 160 Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly
Pro Ser 165 170 175 Gln Gly Arg Ser Pro Ser Tyr Ala Ser Pro Met Val
Pro Glu Glu Pro 180 185 190 Glu Asp Leu Arg Gly His Leu Glu Ser Asp
Met Phe Ser Ser Pro Leu 195 200 205 Glu Thr Asp Ser Met Asp Pro Phe
Gly Leu Val Thr Gly Leu Glu Ala 210 215 220 Val Arg Ser Pro Ser Phe
Glu Lys 225 230 <210> SEQ ID NO 47 <211> LENGTH: 190
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 47 His Pro Ile Pro Asp Ser Ser Pro Leu Leu
Gln Trp Gly Asp Pro Ile 1 5 10 15 Arg Leu Arg His Leu Tyr Thr Ser
Gly Pro His Gly Leu Ser Ser Cys 20 25 30 Phe Leu Arg Ile Arg Ala
Asp Gly Val Val Asp Cys Ala Arg Gly Gln 35 40 45 Ser Ala His Ser
Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 50 55 60 Ala Ile
Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 65 70 75 80
Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 85
90 95 Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu
Lys 100 105 110 His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg
Gln Leu Tyr 115 120 125 Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe
Leu Pro Met Leu Pro 130 135 140 Met Val Pro Glu Glu Pro Glu Asp Leu
Arg Gly His Leu Glu Ser Asp 145 150 155 160 Met Phe Ser Ser Pro Leu
Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 165 170 175 Val Thr Gly Leu
Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ
ID NO 48 <211> LENGTH: 187 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 48 Arg Asp Ser Ser Pro
Leu Leu Gln Phe Gly Gly Gln Val Arg Leu Arg 1 5 10 15 His Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg 20 25 30 Ile
Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His 35 40
45 Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys
50 55 60 Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly
Lys Met 65 70 75 80 Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala
Phe Glu Glu Glu 85 90 95 Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser Glu Lys His Arg Leu 100 105 110 Pro Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln Leu Tyr Lys Asn Arg 115 120 125 Gly Phe Leu Pro Leu Ser
His Phe Leu Pro Met Leu Pro Met Val Pro 130 135 140 Glu Glu Pro Glu
Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser 145 150 155 160 Ser
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly 165 170
175 Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 <210>
SEQ ID NO 49 <211> LENGTH: 192 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 49 Arg Pro
Leu Ala Phe Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 1 5 10 15
Gln Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20
25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150
155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 50 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 50 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Asp Gln 1 5 10 15 Val Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Leu Glu Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 51 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 51 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Asn 1 5 10
15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80
Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85
90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser
Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln
Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His
Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu Pro Glu Asp
Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe Ser Ser Pro
Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu Val Thr Gly
Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190 <210>
SEQ ID NO 52 <211> LENGTH: 187 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 52 Arg Asp
Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro Ile Arg Leu Arg 1 5 10 15
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg 20
25 30 Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala
His 35 40 45 Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val
Ala Ile Lys 50 55 60 Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
Ala Asp Gly Lys Met 65 70 75 80 Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys Ala Phe Glu Glu Glu 85 90 95 Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser Glu Lys His Arg Leu 100 105 110 Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg 115 120 125 Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro 130 135 140 Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser 145 150
155 160 Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr
Gly 165 170 175 Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
<210> SEQ ID NO 53 <211> LENGTH: 189 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 53 Met
Asp Ser Ser Pro Leu Val His Tyr Gly Trp Gly Asp Pro Ile Arg 1 5 10
15 Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe
20 25 30 Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly
Gln Ser 35 40 45 Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu
Arg Thr Val Ala 50 55 60 Ile Lys Gly Val His Ser Val Arg Tyr Leu
Cys Met Gly Ala Asp Gly 65 70 75 80 Lys Met Gln Gly Leu Leu Gln Tyr
Ser Glu Glu Asp Cys Ala Phe Glu 85 90 95 Glu Glu Ile Arg Pro Asp
Gly Tyr Asn Val Tyr Arg Ser Glu Lys His 100 105 110 Arg Leu Pro Val
Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys 115 120 125 Asn Arg
Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met 130 135 140
Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met 145
150 155 160 Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly
Leu Val 165 170 175 Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu
Lys 180 185 <210> SEQ ID NO 54 <211> LENGTH: 192
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 54 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
Leu Leu Gln Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile
Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala
His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60 Thr Val
Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80
Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85
90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser
His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu Glu Pro Glu
Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly Leu Val Thr
Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 55 <211> LENGTH: 192 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 55 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Tyr Gly Trp Gly Asp 1 5 10
15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140
Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145
150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 56 <211>
LENGTH: 192 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 56 Arg Pro Leu Ala Phe Ser Asp Ala
Gly Pro Val Tyr Gly Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65
70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 57 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
57 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro Val His Gly Trp Gly Asp
1 5 10 15
Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20
25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150
155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 58 <211>
LENGTH: 192 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 58 Arg Pro Leu Ala Phe Ser Asp Ala
Gly Pro Val His Tyr Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65
70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 59 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
59 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His His Gly Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 60
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 60 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His His Tyr Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 61 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
61 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val Gly Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 62
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 62 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val Tyr Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175
Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180
185 190 <210> SEQ ID NO 63 <211> LENGTH: 192
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 63 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile
Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala
His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60 Thr Val
Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80
Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85
90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser
His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu Glu Pro Glu
Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly Leu Val Thr
Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 64 <211> LENGTH: 192 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 64 Arg
Pro Leu Ala Phe Ser Asp Ser Ser Pro Leu Val His Trp Gly Asp 1 5 10
15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140
Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145
150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 65 <211>
LENGTH: 192 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 65 Arg Pro Leu Ala Phe Ser Asp Ser
Ser Pro His Val His Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65
70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 66 <211> LENGTH: 192 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
66 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Leu Gln Trp Gly Asp
1 5 10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130
135 140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu
Glu 145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 67
<211> LENGTH: 191 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 67 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val Trp Gly Asp Pro 1 5 10 15 Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55
60 Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala
65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 68 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 68 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Trp Gly 1 5 10
15 Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu
20 25 30 Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp
Cys Ala 35 40 45 Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys
Ala Val Ala Leu 50 55 60 Arg Thr Val Ala Ile Lys Gly Val His Ser
Val Arg Tyr Leu Cys Met 65 70 75 80 Gly Ala Asp Gly Lys Met Gln Gly
Leu Leu Gln Tyr Ser Glu Glu Asp 85 90 95 Cys Ala Phe Glu Glu Glu
Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg 100 105 110
Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg 115
120 125 Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu
Pro 130 135 140 Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg
Gly His Leu 145 150 155 160 Glu Ser Asp Met Phe Ser Ser Pro Leu Glu
Thr Asp Ser Met Asp Pro 165 170 175 Phe Gly Leu Val Thr Gly Leu Glu
Ala Val Arg Ser Pro Ser Phe Glu 180 185 190 Lys <210> SEQ ID
NO 69 <211> LENGTH: 189 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 69 Arg Asp Ser Ser Pro
Leu Val His Tyr Gly Trp Gly Asp Pro Ile Arg 1 5 10 15 Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe 20 25 30 Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser 35 40
45 Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala
50 55 60 Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala
Asp Gly 65 70 75 80 Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala Phe Glu 85 90 95 Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu Lys His 100 105 110 Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu Tyr Lys 115 120 125 Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu Pro Met 130 135 140 Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met 145 150 155 160 Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val 165 170
175 Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
<210> SEQ ID NO 70 <211> LENGTH: 190 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 70 Met
Arg Asp Ser Ser Pro Leu Val His Tyr Gly Trp Gly Asp Pro Ile 1 5 10
15 Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys
20 25 30 Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg
Gly Gln 35 40 45 Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala
Leu Arg Thr Val 50 55 60 Ala Ile Lys Gly Val His Ser Val Arg Tyr
Leu Cys Met Gly Ala Asp 65 70 75 80 Gly Lys Met Gln Gly Leu Leu Gln
Tyr Ser Glu Glu Asp Cys Ala Phe 85 90 95 Glu Glu Glu Ile Arg Pro
Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 100 105 110 His Arg Leu Pro
Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 115 120 125 Lys Asn
Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro 130 135 140
Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp 145
150 155 160 Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe
Gly Leu 165 170 175 Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe
Glu Lys 180 185 190 <210> SEQ ID NO 71 <211> LENGTH:
181 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 71 His Pro Ile Pro Asp Ser Ser Pro Leu Leu
Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Gln Arg Tyr Leu Tyr Thr Asp
Asp Ala Gln Gln Thr Glu Ala His 20 25 30 Leu Glu Ile Arg Glu Asp
Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 35 40 45 Pro Glu Ser Leu
Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 50 55 60 Ile Leu
Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 65 70 75 80
Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 85
90 95 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala
His 100 105 110 Ser Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
Arg Asp Pro 115 120 125 Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu
Pro Gly Leu Pro Pro 130 135 140 Ala Leu Pro Glu Pro Pro Gly Ile Leu
Ala Pro Gln Pro Pro Asp Val 145 150 155 160 Gly Ser Ser Asp Pro Leu
Ser Met Val Gly Pro Ser Gln Gly Arg Ser 165 170 175 Pro Ser Tyr Ala
Ser 180 <210> SEQ ID NO 72 <211> LENGTH: 181
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 72 His Pro Ile Pro Asp Ser Ser Pro Leu Leu
Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Gln Arg Tyr Leu Tyr Thr Asp
Asp Ala Gln Gln Thr Glu Ala His 20 25 30 Leu Glu Ile Arg Glu Asp
Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 35 40 45 Pro Glu Ser Leu
Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 50 55 60 Ile Leu
Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 65 70 75 80
Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 85
90 95 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala
His 100 105 110 Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
Arg Asp Pro 115 120 125 Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu
Pro Gly Leu Pro Pro 130 135 140 Ala Pro Pro Glu Pro Pro Gly Ile Leu
Ala Pro Gln Pro Pro Asp Val 145 150 155 160 Gly Ser Ser Asp Pro Leu
Ser Met Val Gly Pro Ser Gln Gly Arg Ser 165 170 175 Pro Ser Tyr Ala
Ser 180 <210> SEQ ID NO 73 <211> LENGTH: 212
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 73 His Pro Ile Pro Asp Ser Ser Pro Leu Leu
Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Gln Arg Tyr Leu Tyr Thr Asp
Asp Ala Gln Gln Thr Glu Ala His 20 25 30 Leu Glu Ile Arg Glu Asp
Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 35 40 45 Pro Glu Ser Leu
Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 50 55 60 Ile Leu
Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 65 70 75 80
Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 85
90 95 Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala
His 100 105 110 Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His
Arg Asp Pro 115 120 125 Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu
Pro Gly Leu Pro Pro 130 135 140 Ala Leu Pro Glu Pro Pro Gly Ile Leu
Ala Pro Gln Pro Pro Asp Val 145 150 155 160 Gly Ser Ser Asp Pro Leu
Ser Met Val Val Gln Asp Glu Leu Gln Gly 165 170 175 Val Gly Gly Glu
Gly Cys His Met His Pro Glu Asn Cys Lys Thr Leu 180 185 190 Leu Thr
Asp Ile Asp Arg Thr His Thr Glu Lys Pro Val Trp Asp Gly 195 200 205
Ile Thr Gly Glu 210 <210> SEQ ID NO 74 <211> LENGTH:
189 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 74
Arg Asp Ala Gly Pro His Val His Tyr Gly Trp Gly Asp Pro Ile Arg 1 5
10 15 Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys
Phe 20 25 30 Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg
Gly Gln Ser 35 40 45 Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala
Leu Arg Thr Val Ala 50 55 60 Ile Lys Gly Val His Ser Val Arg Tyr
Leu Cys Met Gly Ala Asp Gly 65 70 75 80 Lys Met Gln Gly Leu Leu Gln
Tyr Ser Glu Glu Asp Cys Ala Phe Glu 85 90 95 Glu Glu Ile Arg Pro
Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His 100 105 110 Arg Leu Pro
Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys 115 120 125 Asn
Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met 130 135
140 Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met
145 150 155 160 Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe
Gly Leu Val 165 170 175 Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe
Glu Lys 180 185 <210> SEQ ID NO 75 <211> LENGTH: 184
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 75 Arg Val His Tyr Gly Trp Gly Asp Pro Ile
Arg Leu Arg His Leu Tyr 1 5 10 15 Thr Ser Gly Pro His Gly Leu Ser
Ser Cys Phe Leu Arg Ile Arg Ala 20 25 30 Asp Gly Val Val Asp Cys
Ala Arg Gly Gln Ser Ala His Ser Leu Leu 35 40 45 Glu Ile Lys Ala
Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 50 55 60 Ser Val
Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 65 70 75 80
Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 85
90 95 Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val
Ser 100 105 110 Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg
Gly Phe Leu 115 120 125 Pro Leu Ser His Phe Leu Pro Met Leu Pro Met
Val Pro Glu Glu Pro 130 135 140 Glu Asp Leu Arg Gly His Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu 145 150 155 160 Glu Thr Asp Ser Met Asp
Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 165 170 175 Val Arg Ser Pro
Ser Phe Glu Lys 180 <210> SEQ ID NO 76 <211> LENGTH:
179 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 76 Arg Gly Asp Pro Ile Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His 1 5 10 15 Gly Leu Ser Ser Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp 20 25 30 Cys Ala Arg Gly Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val 35 40 45 Ala Leu Arg Thr
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu 50 55 60 Cys Met
Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu 65 70 75 80
Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val 85
90 95 Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala
Lys 100 105 110 Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu
Ser His Phe 115 120 125 Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro
Glu Asp Leu Arg Gly 130 135 140 His Leu Glu Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met 145 150 155 160 Asp Pro Phe Gly Leu Val
Thr Gly Leu Glu Ala Val Arg Ser Pro Ser 165 170 175 Phe Glu Lys
<210> SEQ ID NO 77 <211> LENGTH: 175 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 77 Arg
Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 1 5 10
15 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly
20 25 30 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu
Arg Thr 35 40 45 Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu
Cys Met Gly Ala 50 55 60 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr
Ser Glu Glu Asp Cys Ala 65 70 75 80 Phe Glu Glu Glu Ile Arg Pro Asp
Gly Tyr Asn Val Tyr Arg Ser Glu 85 90 95 Lys His Arg Leu Pro Val
Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 100 105 110 Tyr Lys Asn Arg
Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 115 120 125 Pro Met
Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 130 135 140
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 145
150 155 160 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu
Lys 165 170 175 <210> SEQ ID NO 78 <211> LENGTH: 188
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 78 Arg Ala Gly Pro His Val His Tyr Gly Trp
Gly Asp Pro Ile Arg Leu 1 5 10 15 Arg His Leu Tyr Thr Ser Gly Pro
His Gly Leu Ser Ser Cys Phe Leu 20 25 30 Arg Ile Arg Ala Asp Gly
Val Val Asp Cys Ala Arg Gly Gln Ser Ala 35 40 45 His Ser Leu Leu
Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile 50 55 60 Lys Gly
Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys 65 70 75 80
Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu 85
90 95 Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His
Arg 100 105 110 Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu
Tyr Lys Asn 115 120 125 Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro
Met Leu Pro Met Val 130 135 140 Pro Glu Glu Pro Glu Asp Leu Arg Gly
His Leu Glu Ser Asp Met Phe 145 150 155 160 Ser Ser Pro Leu Glu Thr
Asp Ser Met Asp Pro Phe Gly Leu Val Thr 165 170 175 Gly Leu Glu Ala
Val Arg Ser Pro Ser Phe Glu Lys 180 185 <210> SEQ ID NO 79
<211> LENGTH: 187 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 79 Arg Gly Pro His Val His Tyr
Gly Trp Gly Asp Pro Ile Arg Leu Arg 1 5 10 15 His Leu Tyr Thr Ser
Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg 20 25 30 Ile Arg Ala
Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His 35 40 45 Ser
Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys 50 55
60 Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met
65 70 75 80 Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu
Glu Glu 85 90 95 Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu
Lys His Arg Leu 100 105 110 Pro Val Ser Leu Ser Ser Ala Lys Gln Arg
Gln Leu Tyr Lys Asn Arg 115 120 125 Gly Phe Leu Pro Leu Ser His Phe
Leu Pro Met Leu Pro Met Val Pro 130 135 140 Glu Glu Pro Glu Asp Leu
Arg Gly His Leu Glu Ser Asp Met Phe Ser 145 150 155 160 Ser Pro Leu
Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly 165 170 175 Leu
Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
<210> SEQ ID NO 80 <211> LENGTH: 186 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 80 Arg
Pro His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His 1 5 10
15 Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile
20 25 30 Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala
His Ser 35 40 45 Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val
Ala Ile Lys Gly 50 55 60 Val His Ser Val Arg Tyr Leu Cys Met Gly
Ala Asp Gly Lys Met Gln 65 70 75 80 Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys Ala Phe Glu Glu Glu Ile 85 90 95 Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser Glu Lys His Arg Leu Pro 100 105 110 Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly 115 120 125 Phe Leu
Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu 130 135 140
Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser 145
150 155 160 Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr
Gly Leu 165 170 175 Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
<210> SEQ ID NO 81 <211> LENGTH: 185 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 81 Arg
His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu 1 5 10
15 Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg
20 25 30 Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His
Ser Leu 35 40 45 Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala
Ile Lys Gly Val 50 55 60 His Ser Val Arg Tyr Leu Cys Met Gly Ala
Asp Gly Lys Met Gln Gly 65 70 75 80 Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala Phe Glu Glu Glu Ile Arg 85 90 95 Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu Lys His Arg Leu Pro Val 100 105 110 Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe 115 120 125 Leu Pro
Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu 130 135 140
Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro 145
150 155 160 Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly
Leu Glu 165 170 175 Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
<210> SEQ ID NO 82 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 82 Arg
Pro Leu Ala Phe Ser Ala Ala Gly Pro His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 83
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 83 Arg Pro Leu Ala Phe Ser Asp
Ala Ala Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala
Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55
60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 84 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 84 Arg Pro Leu Ala Phe Ser Asp Ala Gly Ala
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 85 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 85 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Ala 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu
85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu
Lys <210> SEQ ID NO 86 <211> LENGTH: 194 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
86 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp
1 5 10 15 Gly Ala Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro
His Gly 20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly
Val Val Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu
Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly
Val His Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys
Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe
Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser
Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125
Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130
135 140 Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly
His 145 150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr
Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala
Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO
87 <211> LENGTH: 167 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 87 Arg Pro Leu Ala Phe
Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Ala
Ile Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu 20 25 30 Ile
Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His Ser 35 40
45 Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu
50 55 60 Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg
Pro Asp 65 70 75 80 Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu
Pro Val Ser Leu 85 90 95 Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys
Asn Arg Gly Phe Leu Pro 100 105 110 Leu Ser His Phe Leu Pro Met Leu
Pro Met Val Pro Glu Glu Pro Glu 115 120 125 Asp Leu Arg Gly His Leu
Glu Ser Asp Met Phe Ser Ser Pro Leu Glu 130 135 140 Thr Asp Ser Met
Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val 145 150 155 160 Arg
Ser Pro Ser Phe Glu Lys 165 <210> SEQ ID NO 88 <211>
LENGTH: 194 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 88 Arg Pro Leu Ala Phe Ser Asp Ala
Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu
Arg His Leu Tyr Thr Ser Gly Pro Ala Gly 20 25 30 Leu Ser Ser Cys
Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg
Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60
Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65
70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ala His Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 89 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 89 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro Ala Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser Ala Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 90 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 90 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Ala Gln 115 120 125 Ala Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 91
<211> LENGTH: 194 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 91 Arg Pro
Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15
Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20
25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp
Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys
Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser
Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly
Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu
Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His
Arg Leu Pro Val Ser Leu Ser Ser Ala Ala Gln 115 120 125 Arg Gln Leu
Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ala His Phe Leu 130 135 140 Pro
Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150
155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met
Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser
Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 92
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 92 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala
Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55
60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Ala Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ser Ala Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 93 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 93 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln 115 120 125 Ala Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ala His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 94 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 94 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ala Ala Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 95
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 95 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala
Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55
60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Ala Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ser Ala Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 96 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 96 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95
Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100
105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Ala
Gln 115 120 125 Ala Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ala
His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu
Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu Val Thr
Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 97 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 97 Arg
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Ala Gln 115 120 125 Ala Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser Ala Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 98
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 98 Arg Pro Leu Ala Phe Ser Asp
Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala
Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55
60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Ala Gln 115 120 125 Ala Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ala Ala Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 99 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 99 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
His Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His
Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys Phe Leu
Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg Gly Gln
Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg
Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65 70 75 80
Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85
90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 100 <211> LENGTH: 181 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 100
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 1 5
10 15 Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala
His 20 25 30 Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala
Asp Gln Ser 35 40 45 Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys
Pro Gly Val Ile Gln 50 55 60 Ile Leu Gly Val Lys Thr Ser Arg Phe
Leu Cys Gln Arg Pro Asp Gly 65 70 75 80 Ala Leu Tyr Gly Ser Leu His
Phe Asp Pro Glu Ala Cys Ser Phe Arg 85 90 95 Glu Leu Leu Leu Glu
Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 100 105 110 Gly Leu Pro
Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 115 120 125 Ala
Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 130 135
140 Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val
145 150 155 160 Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln
Gly Arg Ser 165 170 175 Pro Ser Tyr Ala Ser 180 <210> SEQ ID
NO 101 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 101 Val His Tyr Gly 1
<210> SEQ ID NO 102 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 102
Asp Ala Ser Pro His Val His Tyr Gly 1 5 <210> SEQ ID NO 103
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 103 Asp Ser Ser Pro Leu Val His
Tyr Gly 1 5 <210> SEQ ID NO 104 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 104 Asp Ser Ser Pro Leu Leu Gln 1 5
<210> SEQ ID NO 105 <211> LENGTH: 12 <212> TYPE:
PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 105 Asp
Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 1 5 10 <210> SEQ
ID NO 106 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 106 Arg His Pro Ile
Pro 1 5 <210> SEQ ID NO 107 <211> LENGTH: 4 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
107 His Pro Ile Pro 1 <210> SEQ ID NO 108 <211> LENGTH:
5 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 108 Arg Pro Leu Ala Phe 1 5 <210> SEQ
ID NO 109 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 109 Pro Leu Ala Phe 1
<210> SEQ ID NO 110 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 110
Met Asp Ser Ser Pro Leu 1 5 <210> SEQ ID NO 111 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 111 Met Ser Asp Ser Ser Pro Leu 1 5
<210> SEQ ID NO 112 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 112
Ser Asp Ser Ser Pro Leu 1 5 <210> SEQ ID NO 113 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 113 Met Ser Ser Pro Leu 1 5 <210> SEQ
ID NO 114 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 114 Ser Ser Pro Leu 1
<210> SEQ ID NO 115 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 115
Arg Asp Ser Ser 1 <210> SEQ ID NO 116 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 116 Met Asp Ser Ser 1 <210> SEQ ID NO
117 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 117 Met Arg Asp Ser
Ser 1 5 <210> SEQ ID NO 118 <211> LENGTH: 5 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
118 Met Ser Ser Pro Leu 1 5 <210> SEQ ID NO 119 <211>
LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 119 Met Asp Ser Ser Pro Leu 1 5 <210>
SEQ ID NO 120 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 120 Met
Ser Asp Ser Ser Pro Leu 1 5 <210> SEQ ID NO 121 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 121 Asp Ser Ser Pro Leu 1 5 <210> SEQ
ID NO 122 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 122 Asp Ala Ser Pro
His 1 5 <210> SEQ ID NO 123 <211> LENGTH: 4 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
123 Arg Asp Ser Ser 1 <210> SEQ ID NO 124 <211> LENGTH:
4 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 124 Met Asp Ser Ser 1 <210> SEQ ID NO
125 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 125 Met Arg Asp Ser
Ser 1 5 <210> SEQ ID NO 126 <211> LENGTH: 6 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
126 Met Asp Ser Ser Pro Leu 1 5 <210> SEQ ID NO 127
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 127 Met Ser Asp Ser Ser Pro Leu
1 5 <210> SEQ ID NO 128
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 128 Met Ser Ser Pro Leu 1 5
<210> SEQ ID NO 129 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Linker sequence <400> SEQUENCE: 129 Gly Ser Gly Gly Ser 1 5
<210> SEQ ID NO 130 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Linker sequence <400> SEQUENCE: 130 Gly Gly Gly Ser 1
<210> SEQ ID NO 131 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Linker sequence <400> SEQUENCE: 131 Gly Gly Ser Gly 1
<210> SEQ ID NO 132 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Linker sequence <400> SEQUENCE: 132 Gly Gly Ser Gly Gly 1 5
<210> SEQ ID NO 133 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Linker sequence <400> SEQUENCE: 133 Gly Ser Gly Ser Gly 1 5
<210> SEQ ID NO 134 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Linker sequence <400> SEQUENCE: 134 Gly Ser Gly Gly Gly 1 5
<210> SEQ ID NO 135 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Linker sequence <400> SEQUENCE: 135 Gly Ser Ser Ser Gly 1 5
<210> SEQ ID NO 136 <211> LENGTH: 32 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Description of Artificial Sequence:
Forward primer <400> SEQUENCE: 136 ccgactagtc accatgcgga
gcgggtgtgt gg 32 <210> SEQ ID NO 137 <211> LENGTH: 41
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Description of
Artificial Sequence: Reverse primer <400> SEQUENCE: 137
ataagaatgc ggccgcttac ttctcaaagc tgggactcct c 41 <210> SEQ ID
NO 138 <211> LENGTH: 186 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 138 Asp Ser Ser Pro
Leu Leu Gln Phe Gly Gly Gln Val Arg Leu Arg His 1 5 10 15 Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile 20 25 30
Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser 35
40 45 Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys
Gly 50 55 60 Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly
Lys Met Gln 65 70 75 80 Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala
Phe Glu Glu Glu Ile 85 90 95 Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser Glu Lys His Arg Leu Pro 100 105 110 Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln Leu Tyr Lys Asn Arg Gly 115 120 125 Phe Leu Pro Leu Ser
His Phe Leu Pro Met Leu Pro Met Val Pro Glu 130 135 140 Glu Pro Glu
Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser 145 150 155 160
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu 165
170 175 Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 <210>
SEQ ID NO 139 <211> LENGTH: 194 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 139 Arg
Pro Leu Ala Phe Ser Asp Ala Ser Pro His Val His Tyr Gly Trp 1 5 10
15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly
20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val
Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile
Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145
150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser
Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg
Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 140
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 140 Arg Pro Leu Ala Phe Ser Asp
Ser Ser Pro Leu Val His Tyr Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg
Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser
Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala
Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55
60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys
65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95
Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 100
105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys
Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser
His Phe Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu
Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu Val Thr
Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys
<210> SEQ ID NO 141 <211> LENGTH: 188 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 141
Asp Ser Ser Pro Leu Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu 1 5
10 15 Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe
Leu 20 25 30 Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly
Gln Ser Ala 35 40 45 His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu
Arg Thr Val Ala Ile 50 55 60 Lys Gly Val His Ser Val Arg Tyr Leu
Cys Met Gly Ala Asp Gly Lys 65 70 75 80 Met Gln Gly Leu Leu Gln Tyr
Ser Glu Glu Asp Cys Ala Phe Glu Glu 85 90 95 Glu Ile Arg Pro Asp
Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg 100 105 110 Leu Pro Val
Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn 115 120 125 Arg
Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val 130 135
140 Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe
145 150 155 160 Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly
Leu Val Thr 165 170 175 Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu
Lys 180 185 <210> SEQ ID NO 142 <211> LENGTH: 193
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 142 Arg His Pro Ile Pro Asp Ser Ser Pro Leu
Leu Gln Phe Gly Trp Gly 1 5 10 15 Asp Pro Ile Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu 20 25 30 Ser Ser Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala 35 40 45 Arg Gly Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 50 55 60 Arg Thr
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 65 70 75 80
Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 85
90 95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr
Arg 100 105 110 Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala
Lys Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu
Ser His Phe Leu Pro 130 135 140 Met Leu Pro Met Val Pro Glu Glu Pro
Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp Met Phe Ser
Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe Gly Leu Val
Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185 190 Lys
<210> SEQ ID NO 143 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 143
Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro 1 5
10 15 Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
Ser 20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135
140 Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser
145 150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 144 <211>
LENGTH: 194 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 144 Arg Pro Leu Ala Phe Ser Asp Ala
Gly Pro Leu Leu Gln Phe Gly Trp 1 5 10 15 Gly Asp Pro Ile Arg Leu
Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25 30 Leu Ser Ser Cys
Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 35 40 45 Ala Arg
Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 50 55 60
Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 65
70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser
Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly
Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His Arg Leu Pro Val Ser
Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu Tyr Lys Asn Arg Gly
Phe Leu Pro Leu Ser His Phe Leu 130 135 140 Pro Met Leu Pro Met Val
Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150 155 160 Leu Glu Ser
Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 165 170 175 Pro
Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 180 185
190 Glu Lys <210> SEQ ID NO 145 <211> LENGTH: 193
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 145 Arg His Pro Ile Pro Asp Ser Ser Pro His
Val His Tyr Gly Trp Gly 1 5 10 15 Asp Pro Ile Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu 20 25 30 Ser Ser Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala 35 40 45 Arg Gly Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 50 55 60 Arg Thr
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 65 70 75 80
Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp 85
90 95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr
Arg 100 105 110 Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala
Lys Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu
Ser His Phe Leu Pro 130 135 140 Met Leu Pro Met Val Pro Glu Glu Pro
Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp Met Phe Ser
Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe Gly Leu Val
Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185 190 Lys
<210> SEQ ID NO 146 <211> LENGTH: 192 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 146 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
Leu Leu Gln Phe Gly Gly 1 5 10 15 Gln Val Arg Leu Arg His Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe Leu Arg Ile
Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly Gln Ser Ala
His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55 60 Thr Val
Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly 65 70 75 80
Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85
90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser
His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu Glu Pro Glu
Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met Phe Ser Ser
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly Leu Val Thr
Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 147 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 147
Arg His Pro Ile Pro Asp Ser Ser Pro His Val His Tyr Gly Gly Gln 1 5
10 15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
Ser 20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135
140 Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser
145 150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 148 <211>
LENGTH: 187 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 148 Arg Asp Ser Ser Pro Leu Leu Gln
Phe Gly Gly Gln Val Arg Leu Arg 1 5 10 15 His Leu Tyr Thr Ser Gly
Pro His Gly Leu Ser Ser Cys Phe Leu Arg 20 25 30 Ile Arg Ala Asp
Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His 35 40 45 Ser Leu
Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys 50 55 60
Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met 65
70 75 80 Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu
Glu Glu 85 90 95 Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu
Lys His Arg Leu 100 105 110 Pro Val Ser Leu Ser Ser Ala Lys Gln Arg
Gln Leu Tyr Lys Asn Arg 115 120 125 Gly Phe Leu Pro Leu Ser His Phe
Leu Pro Met Leu Pro Met Val Pro 130 135 140 Glu Glu Pro Glu Asp Leu
Arg Gly His Leu Glu Ser Asp Met Phe Ser 145 150 155 160 Ser Pro Leu
Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly 165 170 175 Leu
Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 <210> SEQ ID
NO 149 <211> LENGTH: 192 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 149 Arg Pro Leu Ala
Phe Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 1 5 10 15 Gln Val
Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30
Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35
40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu
Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu
Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr
Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp
Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val
Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg
Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met
Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160
Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165
170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu
Lys 180 185 190 <210> SEQ ID NO 150 <211> LENGTH: 191
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 150 Arg His Pro Ile Pro Asp Ser Ser Pro Leu
Leu Gln Phe Gly Ala Gln 1 5 10 15 Val Arg Leu Arg His Leu Tyr Thr
Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg Ile Arg
Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser Ala His
Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60 Val Ala
Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65 70 75 80
Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85
90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser
Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln
Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His
Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu Pro Glu Asp
Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe Ser Ser Pro
Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu Val Thr Gly
Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190 <210>
SEQ ID NO 151 <211> LENGTH: 191 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 151 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Asp Gln 1 5 10
15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser
145 150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 152 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 152 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Pro Gln 1 5 10 15 Val Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 153 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 153
Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Ala 1 5
10 15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
Ser 20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135
140 Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser
145 150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 154 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 154 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Glu 1 5 10 15 Val Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 155 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 155
Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Asn 1 5
10 15 Val Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
Ser 20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135
140 Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser
145 150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 156 <211>
LENGTH: 191 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 156 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Gly Gln 1 5 10 15 Ala Arg Leu Arg His Leu
Tyr Thr Ser Gly Pro His Gly Leu Ser Ser 20 25 30 Cys Phe Leu Arg
Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly 35 40 45 Gln Ser
Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr 50 55 60
Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala 65
70 75 80 Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp
Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val
Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser
Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro
Leu Ser His Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu
Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe
Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu
Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190
<210> SEQ ID NO 157 <211> LENGTH: 191 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 157
Arg His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 1 5
10 15 Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
Ser 20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly Ala 65 70 75 80
Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala 85
90 95 Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser
Glu 100 105 110 Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln
Arg Gln Leu 115 120 125 Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His
Phe Leu Pro Met Leu 130 135 140 Pro Met Val Pro Glu Glu Pro Glu Asp
Leu Arg Gly His Leu Glu Ser 145 150 155 160 Asp Met Phe Ser Ser Pro
Leu Glu Thr Asp Ser Met Asp Pro Phe Gly 165 170 175 Leu Val Thr Gly
Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190 <210>
SEQ ID NO 158 <211> LENGTH: 191 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 158 Arg
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 1 5 10
15 Thr Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser
20 25 30 Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala
Arg Gly 35 40 45 Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val
Ala Leu Arg Thr 50 55 60 Val Ala Ile Lys Gly Val His Ser Val Arg
Tyr Leu Cys Met Gly Ala 65 70 75 80 Asp Gly Lys Met Gln Gly Leu Leu
Gln Tyr Ser Glu Glu Asp Cys Ala 85 90 95 Phe Glu Glu Glu Ile Arg
Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu 100 105 110 Lys His Arg Leu
Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu 115 120 125 Tyr Lys
Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu 130 135 140
Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser 145
150 155 160 Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro
Phe Gly 165 170 175 Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser
Phe Glu Lys 180 185 190 <210> SEQ ID NO 159 <211>
LENGTH: 193 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 159 Arg His Pro Ile Pro Asp Ser Ser
Pro Leu Leu Gln Phe Gly Trp Gly 1 5 10 15 Gln Pro Val Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu 20 25 30 Ser Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala 35 40 45 Arg Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu 50 55 60
Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met 65
70 75 80 Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu
Glu Asp 85 90 95 Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr
Asn Val Tyr Arg 100 105 110 Ser Glu Lys His Arg Leu Pro Val Ser Leu
Ser Ser Ala Lys Gln Arg 115 120 125 Gln Leu Tyr Lys Asn Arg Gly Phe
Leu Pro Leu Ser His Phe Leu Pro 130 135 140 Met Leu Pro Met Val Pro
Glu Glu Pro Glu Asp Leu Arg Gly His Leu 145 150 155 160 Glu Ser Asp
Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro 165 170 175 Phe
Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu 180 185
190 Lys <210> SEQ ID NO 160 <211> LENGTH: 190
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 160 His Pro Ile Pro Asp Ser Ser Pro Leu Leu
Gln Phe Gly Gly Gln Val 1 5 10 15 Arg Leu Arg His Leu Tyr Thr Ser
Gly Pro His Gly Leu Ser Ser Cys 20 25 30 Phe Leu Arg Ile Arg Ala
Asp Gly Val Val Asp Cys Ala Arg Gly Gln 35 40 45 Ser Ala His Ser
Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 50 55 60 Ala Ile
Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 65 70 75 80
Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 85
90 95 Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu
Lys 100 105 110 His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg
Gln Leu Tyr 115 120 125 Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe
Leu Pro Met Leu Pro 130 135 140 Met Val Pro Glu Glu Pro Glu Asp Leu
Arg Gly His Leu Glu Ser Asp 145 150 155 160 Met Phe Ser Ser Pro Leu
Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 165 170 175 Val Thr Gly Leu
Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 190 <210> SEQ
ID NO 161 <211> LENGTH: 186 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 161 Asp Ser Ser Pro
Leu Leu Gln Phe Gly Gly Gln Val Arg Leu Arg His 1 5 10 15 Leu Tyr
Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile 20 25 30
Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser 35
40 45 Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys
Gly 50 55 60 Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly
Lys Met Gln 65 70 75 80 Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala
Phe Glu Glu Glu Ile 85 90 95 Arg Pro Asp Gly Tyr Asn Val Tyr Arg
Ser Glu Lys His Arg Leu Pro 100 105 110 Val Ser Leu Ser Ser Ala Lys
Gln Arg Gln Leu Tyr Lys Asn Arg Gly 115 120 125 Phe Leu Pro Leu Ser
His Phe Leu Pro Met Leu Pro Met Val Pro Glu 130 135 140 Glu Pro Glu
Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser 145 150 155 160
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu 165
170 175 Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 <210>
SEQ ID NO 162 <211> LENGTH: 190 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 162 His
Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro Ile 1 5 10
15 Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys
20 25 30 Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg
Gly Gln 35 40 45 Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala
Leu Arg Thr Val 50 55 60 Ala Ile Lys Gly Val His Ser Val Arg Tyr
Leu Cys Met Gly Ala Asp 65 70 75 80 Gly Lys Met Gln Gly Leu Leu Gln
Tyr Ser Glu Glu Asp Cys Ala Phe 85 90 95 Glu Glu Glu Ile Arg Pro
Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 100 105 110 His Arg Leu Pro
Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 115 120 125 Lys Asn
Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro 130 135 140
Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp 145
150 155 160 Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe
Gly Leu 165 170 175 Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe
Glu Lys 180 185 190 <210> SEQ ID NO 163 <211> LENGTH:
192 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 163
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Trp Gly Asp 1 5
10 15 Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu
Ser 20 25 30 Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp
Cys Ala Arg 35 40 45 Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys
Ala Val Ala Leu Arg 50 55 60 Thr Val Ala Ile Lys Gly Val His Ser
Val Arg Tyr Leu Cys Met Gly 65 70 75 80 Ala Asp Gly Lys Met Gln Gly
Leu Leu Gln Tyr Ser Glu Glu Asp Cys 85 90 95 Ala Phe Glu Glu Glu
Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser 100 105 110 Glu Lys His
Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln 115 120 125 Leu
Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met 130 135
140 Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu
145 150 155 160 Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met
Asp Pro Phe 165 170 175 Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser
Pro Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 164
<211> LENGTH: 192 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 164 His Pro Ile Pro Asp Ser Ser
Pro His Val His Tyr Gly Trp Gly Asp 1 5 10 15 Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser 20 25 30 Ser Cys Phe
Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg 35 40 45 Gly
Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg 50 55
60 Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
65 70 75 80 Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys 85 90 95 Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser 100 105 110 Glu Lys His Arg Leu Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln 115 120 125 Leu Tyr Lys Asn Arg Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met 130 135 140 Leu Pro Met Val Pro Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu 145 150 155 160 Ser Asp Met
Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe 165 170 175 Gly
Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
190 <210> SEQ ID NO 165 <211> LENGTH: 190 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
165 His Pro Ile Pro Asp Ser Ser Pro His Val His Tyr Gly Gly Gln Val
1 5 10 15 Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser
Ser Cys 20 25 30 Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
Ala Arg Gly Gln 35 40 45 Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala Leu Arg Thr Val 50 55 60 Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys Met Gly Ala Asp 65 70 75 80 Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 85 90 95 Glu Glu Glu Ile
Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 100 105 110 His Arg
Leu Pro Val Ser Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 115 120 125
Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro 130
135 140 Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser
Asp 145 150 155 160 Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp
Pro Phe Gly Leu 165 170 175 Val Thr Gly Leu Glu Ala Val Arg Ser Pro
Ser Phe Glu Lys 180 185 190 <210> SEQ ID NO 166 <211>
LENGTH: 188 <212> TYPE: PRT <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 166 Asp Ala Gly Pro His Val His Tyr
Gly Trp Gly Asp Pro Ile Arg Leu 1 5 10 15 Arg His Leu Tyr Thr Ser
Gly Pro His Gly Leu Ser Ser Cys Phe Leu 20 25 30 Arg Ile Arg Ala
Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala 35 40 45 His Ser
Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile 50 55 60
Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys 65
70 75 80 Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe
Glu Glu 85 90 95 Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser
Glu Lys His Arg 100 105 110 Leu Pro Val Ser Leu Ser Ser Ala Lys Gln
Arg Gln Leu Tyr Lys Asn 115 120 125 Arg Gly Phe Leu Pro Leu Ser His
Phe Leu Pro Met Leu Pro Met Val 130 135 140 Pro Glu Glu Pro Glu Asp
Leu Arg Gly His Leu Glu Ser Asp Met Phe 145 150 155 160 Ser Ser Pro
Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr 165 170 175 Gly
Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185 <210> SEQ
ID NO 167 <211> LENGTH: 183 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 167 Val His Tyr Gly
Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr 1 5 10 15 Ser Gly
Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp 20 25 30
Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu 35
40 45 Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His
Ser 50 55 60 Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln
Gly Leu Leu 65 70 75 80 Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu
Glu Ile Arg Pro Asp 85 90 95 Gly Tyr Asn Val Tyr Arg Ser Glu Lys
His Arg Leu Pro Val Ser Leu 100 105 110 Ser Ser Ala Lys Gln Arg Gln
Leu Tyr Lys Asn Arg Gly Phe Leu Pro 115 120 125 Leu Ser His Phe Leu
Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu 130 135 140 Asp Leu Arg
Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu 145 150 155 160
Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val 165
170 175 Arg Ser Pro Ser Phe Glu Lys 180 <210> SEQ ID NO 168
<211> LENGTH: 174 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 168 Arg Leu Arg His Leu Tyr Thr
Ser Gly Pro His Gly Leu Ser Ser Cys 1 5 10 15 Phe Leu Arg Ile Arg
Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 20 25 30 Ser Ala His
Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 35 40 45 Ala
Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 50 55
60 Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe
65 70 75 80 Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser
Glu Lys 85 90 95 His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln
Arg Gln Leu Tyr 100 105 110 Lys Asn Arg Gly Phe Leu Pro Leu Ser His
Phe Leu Pro Met Leu Pro 115 120 125 Met Val Pro Glu Glu Pro Glu Asp
Leu Arg Gly His Leu Glu Ser Asp 130 135 140 Met Phe Ser Ser Pro Leu
Glu Thr Asp Ser Met Asp Pro Phe Gly Leu 145 150 155 160 Val Thr Gly
Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys
165 170 <210> SEQ ID NO 169 <211> LENGTH: 14
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 169 Trp Gly Asp Pro Ile Arg Leu Arg
His Leu Tyr Thr Ser Gly 1 5 10 <210> SEQ ID NO 170
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 170 Trp Gly
Asp Pro Ile 1 5 <210> SEQ ID NO 171 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 171 Trp Gly Pro Ile 1 <210> SEQ
ID NO 172 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 172 Trp
Gly Asp Pro Val 1 5 <210> SEQ ID NO 173 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 173 Trp Gly Asp Ile 1 <210> SEQ
ID NO 174 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 174 Gly
Asp Pro Ile 1 <210> SEQ ID NO 175 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 175 Trp Gly Gln Pro Ile 1 5
<210> SEQ ID NO 176 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 176 Trp Gly Ala Pro Ile 1 5 <210> SEQ ID NO 177
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 177 Ala Gly
Asp Pro Ile 1 5 <210> SEQ ID NO 178 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 178 Trp Ala Asp Pro Ile 1 5
<210> SEQ ID NO 179 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 179 Trp Gly Asp Ala Ile 1 5 <210> SEQ ID NO 180
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 180 Trp Gly
Asp Pro Ala 1 5 <210> SEQ ID NO 181 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 181 Trp Asp Pro Ile 1 <210> SEQ
ID NO 182 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 182 Trp
Gly Asp Ile 1 <210> SEQ ID NO 183 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 183 Trp Gly Asp Pro 1 <210> SEQ
ID NO 184 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 184 Phe
Gly Asp Pro Ile 1 5 <210> SEQ ID NO 185 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide <400> SEQUENCE: 185 Arg Leu Arg His Leu Tyr Thr Ser
Gly 1 5 <210> SEQ ID NO 186 <211> LENGTH: 9 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: core sequence <400>
SEQUENCE: 186 Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 1 5 <210>
SEQ ID NO 187 <211> LENGTH: 13 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 187 Ala Gly Pro His Val His Tyr Gly Trp Gly Asp Pro Ile 1
5 10 <210> SEQ ID NO 188
<211> LENGTH: 165 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <220> FEATURE: <223> OTHER INFORMATION:
FGF19 C-terminal sequence <400> SEQUENCE: 188 Pro His Gly Leu
Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val 1 5 10 15 Val Asp
Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys 20 25 30
Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg 35
40 45 Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln
Tyr 50 55 60 Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro
Asp Gly Tyr 65 70 75 80 Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro
Val Ser Leu Ser Ser 85 90 95 Ala Lys Gln Arg Gln Leu Tyr Lys Asn
Arg Gly Phe Leu Pro Leu Ser 100 105 110 His Phe Leu Pro Met Leu Pro
Met Val Pro Glu Glu Pro Glu Asp Leu 115 120 125 Arg Gly His Leu Glu
Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp 130 135 140 Ser Met Asp
Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser 145 150 155 160
Pro Ser Phe Glu Lys 165 <210> SEQ ID NO 189 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: Linker
sequence <400> SEQUENCE: 189 Gly Gly Gly Ser Gly 1 5
<210> SEQ ID NO 190 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <220> FEATURE:
<223> OTHER INFORMATION: Sheet-8/Loop-8/Sheet-9 region of
FGF19 <400> SEQUENCE: 190 Glu Glu Ile Arg Pro Asp Gly Tyr Asn
Val Tyr 1 5 10 <210> SEQ ID NO 191 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<220> FEATURE: <223> OTHER INFORMATION:
Sheet-8/Loop-8/Sheet-9 region of FGF21 <400> SEQUENCE: 191
Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 1 5 10 <210> SEQ
ID NO 192 <211> LENGTH: 187 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: M53 sequence <400> SEQUENCE: 192 Met Asp
Ser Ser Pro Leu Leu Gln Trp Gly Asp Pro Ile Arg Leu Arg 1 5 10 15
His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg 20
25 30 Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala
His 35 40 45 Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val
Ala Ile Lys 50 55 60 Gly Val His Ser Val Arg Tyr Leu Cys Met Gly
Ala Asp Gly Lys Met 65 70 75 80 Gln Gly Leu Leu Gln Tyr Ser Glu Glu
Asp Cys Ala Phe Glu Glu Glu 85 90 95 Ile Arg Pro Asp Gly Tyr Asn
Val Tyr Arg Ser Glu Lys His Arg Leu 100 105 110 Pro Val Ser Leu Ser
Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg 115 120 125 Gly Phe Leu
Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro 130 135 140 Glu
Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser 145 150
155 160 Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr
Gly 165 170 175 Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 180 185
<210> SEQ ID NO 193 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: M139 sequence <400> SEQUENCE:
193 Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp
1 5 10 15 Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro
His Gly 20 25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly
Val Val Asp Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu
Glu Ile Lys Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly
Val His Ser Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys
Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe
Glu Glu Glu Ile Leu Pro Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser
Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125
Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130
135 140 Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly
His 145 150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr
Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala
Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO
194 <211> LENGTH: 194 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: M140 sequence <400> SEQUENCE: 194 Arg Pro
Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15
Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20
25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp
Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys
Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser
Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly
Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu
Ile Arg Glu Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His
Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu
Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140 Pro
Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150
155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met
Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser
Pro Ser Phe 180 185 190 Glu Lys <210> SEQ ID NO 195
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: M141 sequence <400> SEQUENCE: 195 Arg Pro Leu
Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15 Gly
Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 20 25
30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys
35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala
Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val
Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly Leu
Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu Ile
Leu Cys Asp Gly Tyr Asn Val Tyr 100 105 110
Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115
120 125 Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe
Leu 130 135 140 Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu
Arg Gly His 145 150 155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu
Glu Thr Asp Ser Met Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu
Glu Ala Val Arg Ser Pro Ser Phe 180 185 190 Glu Lys <210> SEQ
ID NO 196 <211> LENGTH: 194 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: M160 sequence <400> SEQUENCE: 196 Arg Pro
Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 1 5 10 15
Gly Asp Pro Ile Arg Gln Arg His Leu Tyr Thr Ser Gly Pro His Gly 20
25 30 Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp
Cys 35 40 45 Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys
Ala Val Ala 50 55 60 Leu Arg Thr Val Ala Ile Lys Gly Val His Ser
Val Arg Tyr Leu Cys 65 70 75 80 Met Gly Ala Asp Gly Lys Met Gln Gly
Leu Leu Gln Tyr Ser Glu Glu 85 90 95 Asp Cys Ala Phe Glu Glu Glu
Ile Leu Glu Asp Gly Tyr Asn Val Tyr 100 105 110 Arg Ser Glu Lys His
Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 115 120 125 Arg Gln Leu
Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 130 135 140 Pro
Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 145 150
155 160 Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met
Asp 165 170 175 Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser
Pro Ser Phe 180 185 190 Glu Lys
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