U.S. patent application number 16/130295 was filed with the patent office on 2019-02-07 for plant genome modification using guide rna/cas endonuclease systems and methods of use. This patent application is currently assigned to E. I. DU PONT DE NEMOURS AND COMPANY. The applicant listed for this patent is E. I. DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL, INC.. Invention is credited to ANDREW MARK CIGAN, SAVERIO CARL FALCO, HUIRONG GAO, ZHONGSEN LI, ZHAN-BIN LIU, LESZEK ALEKSANDER LYZNIK, JINRUI SHI, SERGEI SVITASHEV, JOSHUA K. YOUNG.
Application Number | 20190040405 16/130295 |
Document ID | / |
Family ID | 51493053 |
Filed Date | 2019-02-07 |
United States Patent Application | 20190040405 |
Kind Code | A1 |
CIGAN; ANDREW MARK ; et al. | February 7, 2019 |
Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification of a nucleotide sequence in the genome of a cell or organism, for gene editing, and/or for inserting or deleting a polynucleotide of interest into or from the genome of a cell or organism. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Breeding methods and methods for selecting plants utilizing a two component RNA guide and Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell.
Inventors: | CIGAN; ANDREW MARK; (MADISON, WI) ; FALCO; SAVERIO CARL; (WILMINGTON, DE) ; GAO; HUIRONG; (JOHNSTON, IA) ; LI; ZHONGSEN; (HOCKESSIN, DE) ; LIU; ZHAN-BIN; (CLIVE, IA) ; LYZNIK; LESZEK ALEKSANDER; (JOHNSTON, IA) ; SHI; JINRUI; (JOHNSTON, IA) ; SVITASHEV; SERGEI; (JOHNSTON, IA) ; YOUNG; JOSHUA K.; (JOHNSTON, IA) | ||||||||||
Applicant: |
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Assignee: | E. I. DU PONT DE NEMOURS AND
COMPANY WILMINGTON DE PIONEER HI-BRED INTERNATIONAL, INC. JOHNSTON IA |
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Family ID: | 51493053 | ||||||||||
Appl. No.: | 16/130295 | ||||||||||
Filed: | September 13, 2018 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
14463687 | Aug 20, 2014 | |||
16130295 | ||||
62023239 | Jul 11, 2014 | |||
61953090 | Mar 14, 2014 | |||
61937045 | Feb 7, 2014 | |||
61882532 | Sep 25, 2013 | |||
61868706 | Aug 22, 2013 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | A01H 1/00 20130101; C12N 2310/10 20130101; C12N 15/113 20130101; C12N 2310/3231 20130101; C12N 15/8213 20130101; C12N 2310/3341 20130101; C12N 15/8216 20130101; C12N 15/8241 20130101; C12N 2310/20 20170501; C12N 2310/315 20130101; C12N 2310/321 20130101; C12N 2310/3521 20130101; C12N 2310/322 20130101; C12N 2310/3533 20130101 |
International Class: | C12N 15/82 20060101 C12N015/82; C12N 15/113 20100101 C12N015/113; C12N 15/81 20060101 C12N015/81; C12Q 1/6895 20180101 C12Q001/6895 |
Sequence CWU 1
1
56714107DNAStreptococcus pyogenes M1 GAS (SF370) 1atggataaga
aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg 60atcactgatg
aatataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc
120cacagtatca aaaaaaatct tataggggct cttttatttg acagtggaga
gacagcggaa 180gcgactcgtc tcaaacggac agctcgtaga aggtatacac
gtcggaagaa tcgtatttgt 240tatctacagg agattttttc aaatgagatg
gcgaaagtag atgatagttt ctttcatcga 300cttgaagagt cttttttggt
ggaagaagac aagaagcatg aacgtcatcc tatttttgga 360aatatagtag
atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa
420aaattggtag attctactga taaagcggat ttgcgcttaa tctatttggc
cttagcgcat 480atgattaagt ttcgtggtca ttttttgatt gagggagatt
taaatcctga taatagtgat 540gtggacaaac tatttatcca gttggtacaa
acctacaatc aattatttga agaaaaccct 600attaacgcaa gtggagtaga
tgctaaagcg attctttctg cacgattgag taaatcaaga 660cgattagaaa
atctcattgc tcagctcccc ggtgagaaga aaaatggctt atttgggaat
720ctcattgctt tgtcattggg tttgacccct aattttaaat caaattttga
tttggcagaa 780gatgctaaat tacagctttc aaaagatact tacgatgatg
atttagataa tttattggcg 840caaattggag atcaatatgc tgatttgttt
ttggcagcta agaatttatc agatgctatt 900ttactttcag atatcctaag
agtaaatact gaaataacta aggctcccct atcagcttca 960atgattaaac
gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga
1020caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa
cggatatgca 1080ggttatattg atgggggagc tagccaagaa gaattttata
aatttatcaa accaatttta 1140gaaaaaatgg atggtactga ggaattattg
gtgaaactaa atcgtgaaga tttgctgcgc 1200aagcaacgga cctttgacaa
cggctctatt ccccatcaaa ttcacttggg tgagctgcat 1260gctattttga
gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt
1320gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg
tggcaatagt 1380cgttttgcat ggatgactcg gaagtctgaa gaaacaatta
ccccatggaa ttttgaagaa 1440gttgtcgata aaggtgcttc agctcaatca
tttattgaac gcatgacaaa ctttgataaa 1500aatcttccaa atgaaaaagt
actaccaaaa catagtttgc tttatgagta ttttacggtt 1560tataacgaat
tgacaaaggt caaatatgtt actgaaggaa tgcgaaaacc agcatttctt
1620tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg
aaaagtaacc 1680gttaagcaat taaaagaaga ttatttcaaa aaaatagaat
gttttgatag tgttgaaatt 1740tcaggagttg aagatagatt taatgcttca
ttaggtacct accatgattt gctaaaaatt 1800attaaagata aagatttttt
ggataatgaa gaaaatgaag atatcttaga ggatattgtt 1860ttaacattga
ccttatttga agatagggag atgattgagg aaagacttaa aacatatgct
1920cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac
tggttgggga 1980cgtttgtctc gaaaattgat taatggtatt agggataagc
aatctggcaa aacaatatta 2040gattttttga aatcagatgg ttttgccaat
cgcaatttta tgcagctgat ccatgatgat 2100agtttgacat ttaaagaaga
cattcaaaaa gcacaagtgt ctggacaagg cgatagttta 2160catgaacata
ttgcaaattt agctggtagc cctgctatta aaaaaggtat tttacagact
2220gtaaaagttg ttgatgaatt ggtcaaagta atggggcggc ataagccaga
aaatatcgtt 2280attgaaatgg cacgtgaaaa tcagacaact caaaagggcc
agaaaaattc gcgagagcgt 2340atgaaacgaa tcgaagaagg tatcaaagaa
ttaggaagtc agattcttaa agagcatcct 2400gttgaaaata ctcaattgca
aaatgaaaag ctctatctct attatctcca aaatggaaga 2460gacatgtatg
tggaccaaga attagatatt aatcgtttaa gtgattatga tgtcgatcac
2520attgttccac aaagtttcct taaagacgat tcaatagaca ataaggtctt
aacgcgttct 2580gataaaaatc gtggtaaatc ggataacgtt ccaagtgaag
aagtagtcaa aaagatgaaa 2640aactattgga gacaacttct aaacgccaag
ttaatcactc aacgtaagtt tgataattta 2700acgaaagctg aacgtggagg
tttgagtgaa cttgataaag ctggttttat caaacgccaa 2760ttggttgaaa
ctcgccaaat cactaagcat gtggcacaaa ttttggatag tcgcatgaat
2820actaaatacg atgaaaatga taaacttatt cgagaggtta aagtgattac
cttaaaatct 2880aaattagttt ctgacttccg aaaagatttc caattctata
aagtacgtga gattaacaat 2940taccatcatg cccatgatgc gtatctaaat
gccgtcgttg gaactgcttt gattaagaaa 3000tatccaaaac ttgaatcgga
gtttgtctat ggtgattata aagtttatga tgttcgtaaa 3060atgattgcta
agtctgagca agaaataggc aaagcaaccg caaaatattt cttttactct
3120aatatcatga acttcttcaa aacagaaatt acacttgcaa atggagagat
tcgcaaacgc 3180cctctaatcg aaactaatgg ggaaactgga gaaattgtct
gggataaagg gcgagatttt 3240gccacagtgc gcaaagtatt gtccatgccc
caagtcaata ttgtcaagaa aacagaagta 3300cagacaggcg gattctccaa
ggagtcaatt ttaccaaaaa gaaattcgga caagcttatt 3360gctcgtaaaa
aagactggga tccaaaaaaa tatggtggtt ttgatagtcc aacggtagct
3420tattcagtcc tagtggttgc taaggtggaa aaagggaaat cgaagaagtt
aaaatccgtt 3480aaagagttac tagggatcac aattatggaa agaagttcct
ttgaaaaaaa tccgattgac 3540tttttagaag ctaaaggata taaggaagtt
aaaaaagact taatcattaa actacctaaa 3600tatagtcttt ttgagttaga
aaacggtcgt aaacggatgc tggctagtgc cggagaatta 3660caaaaaggaa
atgagctggc tctgccaagc aaatatgtga attttttata tttagctagt
3720cattatgaaa agttgaaggg tagtccagaa gataacgaac aaaaacaatt
gtttgtggag 3780cagcataagc attatttaga tgagattatt gagcaaatca
gtgaattttc taagcgtgtt 3840attttagcag atgccaattt agataaagtt
cttagtgcat ataacaaaca tagagacaaa 3900ccaatacgtg aacaagcaga
aaatattatt catttattta cgttgacgaa tcttggagct 3960cccgctgctt
ttaaatattt tgatacaaca attgatcgta aacgatatac gtctacaaaa
4020gaagttttag atgccactct tatccatcaa tccatcactg gtctttatga
aacacgcatt 4080gatttgagtc agctaggagg tgactga 41072189DNASolanum
tuberosum 2gtaagtttct gcttctacct ttgatatata tataataatt atcattaatt
agtagtaata 60taatatttca aatatttttt tcaaaataaa agaatgtagt atatagcaat
tgcttttctg 120tagtttataa gtgtgtatat tttaatttat aacttttcta
atatatgacc aaaacatggt 180gatgtgcag 18939PRTSimian virus 40 3Met Ala
Pro Lys Lys Lys Arg Lys Val 1 5 418PRTAgrobacterium tumefaciens
4Lys Arg Pro Arg Asp Arg His Asp Gly Glu Leu Gly Gly Arg Lys Arg 1
5 10 15 Ala Arg 56717DNAArtificial SequenceMaize optimized Cas9
expression cassette 5gtgcagcgtg acccggtcgt gcccctctct agagataatg
agcattgcat gtctaagtta 60taaaaaatta ccacatattt tttttgtcac acttgtttga
agtgcagttt atctatcttt 120atacatatat ttaaacttta ctctacgaat
aatataatct atagtactac aataatatca 180gtgttttaga gaatcatata
aatgaacagt tagacatggt ctaaaggaca attgagtatt 240ttgacaacag
gactctacag ttttatcttt ttagtgtgca tgtgttctcc tttttttttg
300caaatagctt cacctatata atacttcatc cattttatta gtacatccat
ttagggttta 360gggttaatgg tttttataga ctaatttttt tagtacatct
attttattct attttagcct 420ctaaattaag aaaactaaaa ctctatttta
gtttttttat ttaataattt agatataaaa 480tagaataaaa taaagtgact
aaaaattaaa caaataccct ttaagaaatt aaaaaaacta 540aggaaacatt
tttcttgttt cgagtagata atgccagcct gttaaacgcc gtcgacgagt
600ctaacggaca ccaaccagcg aaccagcagc gtcgcgtcgg gccaagcgaa
gcagacggca 660cggcatctct gtcgctgcct ctggacccct ctcgagagtt
ccgctccacc gttggacttg 720ctccgctgtc ggcatccaga aattgcgtgg
cggagcggca gacgtgagcc ggcacggcag 780gcggcctcct cctcctctca
cggcaccggc agctacgggg gattcctttc ccaccgctcc 840ttcgctttcc
cttcctcgcc cgccgtaata aatagacacc ccctccacac cctctttccc
900caacctcgtg ttgttcggag cgcacacaca cacaaccaga tctcccccaa
atccacccgt 960cggcacctcc gcttcaaggt acgccgctcg tcctcccccc
cccccctctc taccttctct 1020agatcggcgt tccggtccat gcatggttag
ggcccggtag ttctacttct gttcatgttt 1080gtgttagatc cgtgtttgtg
ttagatccgt gctgctagcg ttcgtacacg gatgcgacct 1140gtacgtcaga
cacgttctga ttgctaactt gccagtgttt ctctttgggg aatcctggga
1200tggctctagc cgttccgcag acgggatcga tttcatgatt ttttttgttt
cgttgcatag 1260ggtttggttt gcccttttcc tttatttcaa tatatgccgt
gcacttgttt gtcgggtcat 1320cttttcatgc ttttttttgt cttggttgtg
atgatgtggt ctggttgggc ggtcgttcta 1380gatcggagta gaattctgtt
tcaaactacc tggtggattt attaattttg gatctgtatg 1440tgtgtgccat
acatattcat agttacgaat tgaagatgat ggatggaaat atcgatctag
1500gataggtata catgttgatg cgggttttac tgatgcatat acagagatgc
tttttgttcg 1560cttggttgtg atgatgtggt gtggttgggc ggtcgttcat
tcgttctaga tcggagtaga 1620atactgtttc aaactacctg gtgtatttat
taattttgga actgtatgtg tgtgtcatac 1680atcttcatag ttacgagttt
aagatggatg gaaatatcga tctaggatag gtatacatgt 1740tgatgtgggt
tttactgatg catatacatg atggcatatg cagcatctat tcatatgctc
1800taaccttgag tacctatcta ttataataaa caagtatgtt ttataattat
tttgatcttg 1860atatacttgg atgatggcat atgcagcagc tatatgtgga
tttttttagc cctgccttca 1920tacgctattt atttgcttgg tactgtttct
tttgtcgatg ctcaccctgt tgtttggtgt 1980tacttctgca ggtcgactct
agaggatcca tggcaccgaa gaagaagcgc aaggtgatgg 2040acaagaagta
cagcatcggc ctcgacatcg gcaccaactc ggtgggctgg gccgtcatca
2100cggacgaata taaggtcccg tcgaagaagt tcaaggtcct cggcaataca
gaccgccaca 2160gcatcaagaa aaacttgatc ggcgccctcc tgttcgatag
cggcgagacc gcggaggcga 2220ccaggctcaa gaggaccgcc aggagacggt
acactaggcg caagaacagg atctgctacc 2280tgcaggagat cttcagcaac
gagatggcga aggtggacga ctccttcttc caccgcctgg 2340aggaatcatt
cctggtggag gaggacaaga agcatgagcg gcacccaatc ttcggcaaca
2400tcgtcgacga ggtaagtttc tgcttctacc tttgatatat atataataat
tatcattaat 2460tagtagtaat ataatatttc aaatattttt ttcaaaataa
aagaatgtag tatatagcaa 2520ttgcttttct gtagtttata agtgtgtata
ttttaattta taacttttct aatatatgac 2580caaaacatgg tgatgtgcag
gtggcctacc acgagaagta cccgacaatc taccacctcc 2640ggaagaaact
ggtggacagc acagacaagg cggacctccg gctcatctac cttgccctcg
2700cgcatatgat caagttccgc ggccacttcc tcatcgaggg cgacctgaac
ccggacaact 2760ccgacgtgga caagctgttc atccagctcg tgcagacgta
caatcaactg ttcgaggaga 2820accccataaa cgctagcggc gtggacgcca
aggccatcct ctcggccagg ctctcgaaat 2880caagaaggct ggagaacctt
atcgcgcagt tgccaggcga aaagaagaac ggcctcttcg 2940gcaaccttat
tgcgctcagc ctcggcctga cgccgaactt caaatcaaac ttcgacctcg
3000cggaggacgc caagctccag ctctcaaagg acacctacga cgacgacctc
gacaacctcc 3060tggcccagat aggagaccag tacgcggacc tcttcctcgc
cgccaagaac ctctccgacg 3120ctatcctgct cagcgacatc cttcgggtca
acaccgaaat taccaaggca ccgctgtccg 3180ccagcatgat taaacgctac
gacgagcacc atcaggacct cacgctgctc aaggcactcg 3240tccgccagca
gctccccgag aagtacaagg agatcttctt cgaccaatca aaaaacggct
3300acgcgggata tatcgacggc ggtgccagcc aggaagagtt ctacaagttc
atcaaaccaa 3360tcctggagaa gatggacggc accgaggagt tgctggtcaa
gctcaacagg gaggacctcc 3420tcaggaagca gaggaccttc gacaacggct
ccatcccgca tcagatccac ctgggcgaac 3480tgcatgccat cctgcggcgc
caggaggact tctacccgtt cctgaaggat aaccgggaga 3540agatcgagaa
gatcttgacg ttccgcatcc catactacgt gggcccgctg gctcgcggca
3600actcccggtt cgcctggatg acccggaagt cggaggagac catcacaccc
tggaactttg 3660aggaggtggt cgataagggc gctagcgctc agagcttcat
cgagcgcatg accaacttcg 3720ataaaaacct gcccaatgaa aaagtcctcc
ccaagcactc gctgctctac gagtacttca 3780ccgtgtacaa cgagctcacc
aaggtcaaat acgtcaccga gggcatgcgg aagccggcgt 3840tcctgagcgg
cgagcagaag aaggcgatag tggacctcct cttcaagacc aacaggaagg
3900tgaccgtgaa gcaattaaaa gaggactact tcaagaaaat agagtgcttc
gactccgtgg 3960agatctcggg cgtggaggat cggttcaacg cctcactcgg
cacgtatcac gacctcctca 4020agatcattaa agacaaggac ttcctcgaca
acgaggagaa cgaggacatc ctcgaggaca 4080tcgtcctcac cctgaccctg
ttcgaggacc gcgaaatgat cgaggagagg ctgaagacct 4140acgcgcacct
gttcgacgac aaggtcatga aacagctcaa gaggcgccgc tacactggtt
4200ggggaaggct gtcccgcaag ctcattaatg gcatcaggga caagcagagc
ggcaagacca 4260tcctggactt cctcaagtcc gacgggttcg ccaaccgcaa
cttcatgcag ctcattcacg 4320acgactcgct cacgttcaag gaagacatcc
agaaggcaca ggtgagcggg cagggtgact 4380ccctccacga acacatcgcc
aacctggccg gctcgccggc cattaaaaag ggcatcctgc 4440agacggtcaa
ggtcgtcgac gagctcgtga aggtgatggg ccggcacaag cccgaaaata
4500tcgtcataga gatggccagg gagaaccaga ccacccaaaa agggcagaag
aactcgcgcg 4560agcggatgaa acggatcgag gagggcatta aagagctcgg
gtcccagatc ctgaaggagc 4620accccgtgga aaatacccag ctccagaatg
aaaagctcta cctctactac ctgcagaacg 4680gccgcgacat gtacgtggac
caggagctgg acattaatcg gctatcggac tacgacgtcg 4740accacatcgt
gccgcagtcg ttcctcaagg acgatagcat cgacaacaag gtgctcaccc
4800ggtcggataa aaatcggggc aagagcgaca acgtgcccag cgaggaggtc
gtgaagaaga 4860tgaaaaacta ctggcgccag ctcctcaacg cgaaactgat
cacccagcgc aagttcgaca 4920acctgacgaa ggcggaacgc ggtggcttga
gcgaactcga taaggcgggc ttcataaaaa 4980ggcagctggt cgagacgcgc
cagatcacga agcatgtcgc ccagatcctg gacagccgca 5040tgaatactaa
gtacgatgaa aacgacaagc tgatccggga ggtgaaggtg atcacgctga
5100agtccaagct cgtgtcggac ttccgcaagg acttccagtt ctacaaggtc
cgcgagatca 5160acaactacca ccacgcccac gacgcctacc tgaatgcggt
ggtcgggacc gccctgatca 5220agaagtaccc gaagctggag tcggagttcg
tgtacggcga ctacaaggtc tacgacgtgc 5280gcaaaatgat cgccaagtcc
gagcaggaga tcggcaaggc cacggcaaaa tacttcttct 5340actcgaacat
catgaacttc ttcaagaccg agatcaccct cgcgaacggc gagatccgca
5400agcgcccgct catcgaaacc aacggcgaga cgggcgagat cgtctgggat
aagggccggg 5460atttcgcgac ggtccgcaag gtgctctcca tgccgcaagt
caatatcgtg aaaaagacgg 5520aggtccagac gggcgggttc agcaaggagt
ccatcctccc gaagcgcaac tccgacaagc 5580tcatcgcgag gaagaaggat
tgggacccga aaaaatatgg cggcttcgac agcccgaccg 5640tcgcatacag
cgtcctcgtc gtggcgaagg tggagaaggg caagtcaaag aagctcaagt
5700ccgtgaagga gctgctcggg atcacgatta tggagcggtc ctccttcgag
aagaacccga 5760tcgacttcct agaggccaag ggatataagg aggtcaagaa
ggacctgatt attaaactgc 5820cgaagtactc gctcttcgag ctggaaaacg
gccgcaagag gatgctcgcc tccgcaggcg 5880agttgcagaa gggcaacgag
ctcgccctcc cgagcaaata cgtcaatttc ctgtacctcg 5940ctagccacta
tgaaaagctc aagggcagcc cggaggacaa cgagcagaag cagctcttcg
6000tggagcagca caagcattac ctggacgaga tcatcgagca gatcagcgag
ttctcgaagc 6060gggtgatcct cgccgacgcg aacctggaca aggtgctgtc
ggcatataac aagcaccgcg 6120acaaaccaat acgcgagcag gccgaaaata
tcatccacct cttcaccctc accaacctcg 6180gcgctccggc agccttcaag
tacttcgaca ccacgattga ccggaagcgg tacacgagca 6240cgaaggaggt
gctcgatgcg acgctgatcc accagagcat cacagggctc tatgaaacac
6300gcatcgacct gagccagctg ggcggagaca agagaccacg ggaccgccac
gatggcgagc 6360tgggaggccg caagcgggca aggtaggtac cgttaaccta
gacttgtcca tcttctggat 6420tggccaactt aattaatgta tgaaataaaa
ggatgcacac atagtgacat gctaatcact 6480ataatgtggg catcaaagtt
gtgtgttatg tgtaattact agttatctga ataaaagaga 6540aagagatcat
ccatatttct tatcctaaat gaatgtcacg tgtctttata attctttgat
6600gaaccagatg catttcatta accaaatcca tatacatata aatattaatc
atatataatt 6660aatatcaatt gggttagcaa aacaaatcta gtctaggtgt
gttttgcgaa tgcggcc 6717639RNAArtificial SequencecrRNA containing
the LIGCas-3 target sequence in the variable targeting domain
6gcguacgcgu acgugugguu uuagagcuau gcuguuuug 39786RNAStreptococcus
pyogenes M1 GAS (SF370)tracRNA(1)..(86) 7ggaaccauuc aaaacagcau
agcaaguuaa aauaaggcua guccguuauc aacuugaaaa 60aguggcaccg agucggugcu
uuuuuu 86894RNAArtificial SequenceLong guide RNA containing the
LIGCas-3 target sequence in the variable targeting domain
8gcguacgcgu acgugugguu uuagagcuag aaauagcaag uuaaaauaag gcuaguccgu
60uaucaacuug aaaaaguggc accgagucgg ugcu 9491000DNAZea mays
9tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag
60tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc
120ccggattaat tcctagccgg attacttctc taatttatat agattttgat
gagctggaat 180gaatcctggc ttattccggt acaaccgaac aggccctgaa
ggataccagt aatcgctgag 240ctaaattggc atgctgtcag agtgtcagta
ttgcagcaag gtagtgagat aaccggcatc 300atggtgccag tttgatggca
ccattagggt tagagatggt ggccatgggc gcatgtcctg 360gccaactttg
tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg
420gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga
gggggcatca 480aagatctggc tgtgtttcca gctgtttttg ttagccccat
cgaatccttg acataatgat 540cccgcttaaa taagcaacct cgcttgtata
gttccttgtg ctctaacaca cgatgatgat 600aagtcgtaaa atagtggtgt
ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct 660attcgaattt
ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt
720ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata
tttgcaaaaa 780agtaaaagag aaagtcatag cggcgtatgt gccaaaaact
tcgtcacaga gagggccata 840agaaacatgg cccacggccc aatacgaagc
accgcgacga agcccaaaca gcagtccgta 900ggtggagcaa agcgctgggt
aatacgcaaa cgttttgtcc caccttgact aatcacaaga 960gtggagcgta
ccttataaac cgagccgcaa gcaccgaatt 10001016DNAZea mays 10tttttttttt
tttttt 161159RNAArtificial SequenceShort guide RNA containing the
LIGCas-3 variable targeting domain 11gcguacgcgu acgugugguu
uuagagcuag aaauagcaag uuaaaauaag gcuaguccg 59121102DNAArtificial
SequenceMaize optimized long guide RNA expression cassette
containing the LIGCas-3 variable targeting domain 12tgagagtaca
atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag 60tctatgatcc
agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc
120ccggattaat tcctagccgg attacttctc taatttatat agattttgat
gagctggaat 180gaatcctggc ttattccggt acaaccgaac aggccctgaa
ggataccagt aatcgctgag 240ctaaattggc atgctgtcag agtgtcagta
ttgcagcaag gtagtgagat aaccggcatc 300atggtgccag tttgatggca
ccattagggt tagagatggt ggccatgggc gcatgtcctg 360gccaactttg
tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg
420gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga
gggggcatca 480aagatctggc tgtgtttcca gctgtttttg ttagccccat
cgaatccttg acataatgat 540cccgcttaaa taagcaacct cgcttgtata
gttccttgtg ctctaacaca cgatgatgat 600aagtcgtaaa atagtggtgt
ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct 660attcgaattt
ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt
720ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata
tttgcaaaaa 780agtaaaagag aaagtcatag cggcgtatgt gccaaaaact
tcgtcacaga gagggccata 840agaaacatgg cccacggccc aatacgaagc
accgcgacga agcccaaaca gcagtccgta 900ggtggagcaa agcgctgggt
aatacgcaaa cgttttgtcc caccttgact aatcacaaga 960gtggagcgta
ccttataaac cgagccgcaa gcaccgaatt gcgtacgcgt acgtgtggtt
1020ttagagctag aaatagcaag ttaaaataag gctagtccgt tatcaacttg
aaaaagtggc 1080accgagtcgg tgcttttttt tt 11021327DNAZea mays
13gtactccatc cgccccatcg agtaggg 271424DNAZea mays 14gcacgtacgt
caccatcccg ccgg 241524DNAZea mays 15gacgtacgtg ccctactcga tggg
241624DNAZea mays 16gtaccgtacg tgccccggcg gagg 241724DNAZea mays
17ggaattgtac cgtacgtgcc ccgg 241820DNAZea mays 18gcgtacgcgt
acgtgtgagg 201922DNAZea mays 19gctggccgag gtcgactacc gg
222023DNAZea mays 20ggccgaggtc gactaccggc cgg 232123DNAZea mays
21ggcgcgagct cgtgcttcac cgg 232221DNAZea mays 22ggtgccaatc
atgcgtcgcg g 212320DNAZea mays 23ggtcgccatc acgggacagg 202424DNAZea
mays 24gtcgcggcac ctgtcccgtg atgg 242523DNAZea mays 25ggaatgctgg
aactgcaatg cgg 232624DNAZea mays 26gcagctcttc ttggggaatg ctgg
242723DNAZea mays 27gcagtaacag ctgctgtcaa tgg 232856DNAArtificial
SequenceMS26Cas-1 forward primer 28ctacactctt tccctacacg acgctcttcc
gatctaggac cggaagctcg ccgcgt 562954DNAArtificial SequenceMS26Cas-1
and MS26Cas-3 reverse primer 29caagcagaag acggcatacg agctcttccg
atcttcctgg aggacgacgt gctg 543059DNAArtificial SequenceMS26Cas-2
forward primer 30ctacactctt tccctacacg acgctcttcc gatctaaggt
cctggaggac gacgtgctg 593151DNAArtificial SequenceMS26Cas-2 and MS26
meganuclease reverse primer 31caagcagaag acggcatacg agctcttccg
atctccggaa gctcgccgcg t 513256DNAArtificial SequenceMS26Cas-3
forward primer 32ctacactctt tccctacacg acgctcttcc gatcttcctc
cggaagctcg ccgcgt 563359DNAArtificial SequenceMS26 Meganuclease
forward primer 33ctacactctt tccctacacg acgctcttcc gatctttcct
cctggaggac gacgtgctg 593463DNAArtificial SequenceLIGCas-1 forward
primer 34ctacactctt tccctacacg acgctcttcc gatctaggac tgtaacgatt
tacgcacctg 60ctg 633558DNAArtificial SequenceLIGCas-1 and LIGCas-2
reverse primer 35caagcagaag acggcatacg agctcttccg atctgcaaat
gagtagcagc gcacgtat 583663DNAArtificial SequenceLIGCas-2 forward
primer 36ctacactctt tccctacacg acgctcttcc gatcttcctc tgtaacgatt
tacgcacctg 60ctg 633760DNAArtificial SequenceLIGCas-3 forward
primer 37ctacactctt tccctacacg acgctcttcc gatctaaggc gcaaatgagt
agcagcgcac 603857DNAArtificial SequenceLIGCas-3 and LIG3-4
meganuclease reverse primer 38caagcagaag acggcatacg agctcttccg
atctcacctg ctgggaattg taccgta 573960DNAArtificial SequenceLIG3-4
meganuclease forward primer 39ctacactctt tccctacacg acgctcttcc
gatctccttc gcaaatgagt agcagcgcac 604058DNAArtificial
SequenceMS45Cas-1 forward primer 40ctacactctt tccctacacg acgctcttcc
gatctaggag gacccgttcg gcctcagt 584154DNAArtificial
SequenceMS45Cas-1, MS45Cas-2 and MS45Cas-3 reverse primer
41caagcagaag acggcatacg agctcttccg atctgccggc tggcattgtc tctg
544258DNAArtificial SequenceMS45Cas-2 forward primer 42ctacactctt
tccctacacg acgctcttcc gatcttcctg gacccgttcg gcctcagt
584358DNAArtificial SequenceMS45Cas-3 forward primer 43ctacactctt
tccctacacg acgctcttcc gatctgaagg gacccgttcg gcctcagt
584458DNAArtificial SequenceALSCas-1 forward primer 44ctacactctt
tccctacacg acgctcttcc gatctaaggc gacgatgggc gtctcctg
584553DNAArtificial SequenceALSCas-1, ALSCas-2 and ALSCas-3 reverse
primer 45caagcagaag acggcatacg agctcttccg atctgcgtct gcatcgccac ctc
534658DNAArtificial SequenceALSCas-2 forward primer 46ctacactctt
tccctacacg acgctcttcc gatctttccc gacgatgggc gtctcctg
584758DNAArtificial SequenceALSCas-3 forward primer 47ctacactctt
tccctacacg acgctcttcc gatctggaac gacgatgggc gtctcctg
584863DNAArtificial SequenceEPSPSCas-1 forward primer 48ctacactctt
tccctacacg acgctcttcc gatctggaag aggaaacata cgttgcattt 60cca
634957DNAArtificial SequencePSPSCas-1 and EPSPSCas-3 reverse primer
49caagcagaag acggcatacg agctcttccg atctggtgga aagttcccag ttgagga
575062DNAArtificial SequencePSPSCas-2 forward primer 50ctacactctt
tccctacacg acgctcttcc gatctaagcg gtggaaagtt cccagttgag 60ga
625158DNAArtificial SequenceEPSPSCas-2 reverse primer 51caagcagaag
acggcatacg agctcttccg atctgaggaa acatacgttg catttcca
585263DNAArtificial SequenceEPSPSCas-3 forward primer 52ctacactctt
tccctacacg acgctcttcc gatctccttg aggaaacata cgttgcattt 60cca
635343DNAArtificial SequenceForward primer for secondary PCR
53aatgatacgg cgaccaccga gatctacact ctttccctac acg
435418DNAArtificial SequenceReverse primer for secondary PCR
54caagcagaag acggcata 185593DNAZea mays 55ctgtaacgat ttacgcacct
gctgggaatt gtaccgtacg tgccccggcg gaggatatat 60atacctcaca cgtacgcgta
cgcgtatata tac 935698DNAArtificial sequenceMutation 1 for LIGCas-1
locus 56aggactgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc
ggtcggagga 60tatatatacc tcacacgtac gcgtacgcgt atatatac
985798DNAArtificial sequenceMutation 2 for LIGCas-1 locus
57aggactgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggacggagga
60tatatatacc tcacacgtac gcgtacgcgt atatatac 985898DNAArtificial
sequenceMutation 3 for LIGCas-1 locus 58aggactgtaa cgatttacgc
acctgctggg aattgtaccg tacgtgcccc gggcggagga 60tatatatacc tcacacgtac
gcgtacgcgt atatatac 985995DNAArtificial sequenceMutation 4 for
LIGCas-1 locus 59aggactgtaa cgatttacgc acctgctggg aattgtaccg
tacgtgcggt cggaggatat 60atatacctca cacgtacgcg tacgcgtata tatac
956098DNAArtificial SequenceMutation 5 for LIGCas-1 locus
60aggactgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggccggagga
60tatatatacc tcacacgtac gcgtacgcgt atatatac 986196DNAArtificial
sequenceMutation 6 for LIGCas-1 locus 61aggactgtaa cgatttacgc
acctgctggg aattgtaccg tacgtgcccc gcggaggata 60tatatacctc acacgtacgc
gtacgcgtat atatac 966296DNAArtificial SequenceMutation 7 for
LIGCas-1 locus 62aggactgtaa cgatttacgc acctgctggg aattgtaccg
tacgtgcccc ggggaggata 60tatatacctc acacgtacgc gtacgcgtat atatac
966394DNAArtificial SequenceMutation 8 for LIGCas-1 locus
63aggactgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggaggatata
60tatacctcac acgtacgcgt acgcgtatat atac 946494DNAArtificial
SequenceMutation 8 for LIGCas-1 locus 64aggactgtaa cgatttacgc
acctgctggg aattgtaccg tacgtgcgtc ggaggatata 60tatacctcac acgtacgcgt
acgcgtatat atac 946543DNAArtificial SequenceMutation 10 for
LIGCas-1 locus 65aggactgtaa cgatttacgc acctgctggg aattgtaccg tac
436698DNAArtificial SequenceMutation 1 for LIGCas-2 locus
66tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgaccc cggcggagga
60tatatatacc tcacacgtac gcgtacgcgt atatatac 986796DNAArtificial
SequenceMutation 2 for LIGCas-2 locus 67tcctctgtaa cgatttacgc
acctgctggg aattgtaccg tacgtccccg gcggaggata 60tatatacctc acacgtacgc
gtacgcgtat atatac 966898DNAArtificial SequenceMutation 3 for
LIGCas-2 locus 68tcctctgtaa cgatttacgc acctgctggg aattgtaccg
tacgtgtccc cggcggagga 60tatatatacc tcacacgtac gcgtacgcgt atatatac
986994DNAArtificial SequenceMutation 4 for LIGCas-2 locus
69tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacccccggc ggaggatata
60tatacctcac acgtacgcgt acgcgtatat atac 947093DNAArtificial
SequenceMutation 5 for LIGCas-2 locus 70tcctctgtaa cgatttacgc
acctgctggg aattgtaccg taccccggcg gaggatatat 60atacctcaca cgtacgcgta
cgcgtatata tac 937198DNAArtificial SequenceMutation 6 for LIGCas-2
locus 71tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtggccc
cggcggagga 60tatatatacc tcacacgtac gcgtacgcgt atatatac
987292DNAArtificial SequenceMutation 7 for LIGCas-2 locus
72tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacccggcgg aggatatata
60tacctcacac gtacgcgtac gcgtatatat ac 927399DNAArtificial
SequenceMutation 8 for LIGCas-2 locus 73tcctctgtaa cgatttacgc
acctgctggg aattgtaccg tacgtgaacc ccggcggagg 60atatatatac ctcacacgta
cgcgtacgcg tatatatac 997461DNAArtificial SequenceMutation 9 for
LIGCas-2 locus 74tcctctgtaa cgatttacgc acctgctggg aattgtaccg
tacgtgtacg cgtatatata 60c 617595DNAArtificial SequenceMutation 10
for LIGCas-2 locus 75tcctctgtaa cgatttacgc acctgctggg aattgtaccg
tacgccccgg cggaggatat 60atatacctca cacgtacgcg tacgcgtata tatac
957693DNAZea mays 76cgcaaatgag tagcagcgca cgtatatata cgcgtacgcg
tacgtgtgag gtatatatat 60cctccgccgg ggcacgtacg gtacaattcc cag
937798DNAArtificial SequenceMutation 1 for LIGCas-3 locus
77aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacgtt gtgaggtata
60tatatcctcc gccggggcac gtacggtaca attcccag 987896DNAArtificial
SequenceMutation 2 for LIGCas-3 locus 78aaggcgcaaa tgagtagcag
cgcacgtata tatacgcgta cgcgtacggt gaggtatata 60tatcctccgc cggggcacgt
acggtacaat tcccag 967996DNAArtificial SequenceMutation 3 for
LIGCas-3 locus 79aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta
cgcgtactgt gaggtatata 60tatcctccgc cggggcacgt acggtacaat tcccag
968095DNAArtificial SequenceMutation 4 for LIGCas-3 locus
80aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacgtg aggtatatat
60atcctccgcc ggggcacgta cggtacaatt cccag 958168DNAArtificial
SequenceMutation 5 for LIGCas-3 locus 81aaggcgcaaa tgagtagcag
cgcacgtata tatatcctcc gccggggcac gtacggtaca 60attcccag
688255DNAArtificial SequenceMutation 6 for LIGCas-3 locus
82aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cggtacaatt cccag
558393DNAArtificial SequenceMutation 7 for LIGCas-3 locus
83aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtgtgag gtatatatat
60cctccgccgg ggcacgtacg gtacaattcc cag 938469DNAArtificial
SequenceMutation 8 for LIGCas-3 locus 84aaggcgcaaa tgagtagcag
cgcacgtata tatacgcgta cgccggggca cgtacggtac 60aattcccag
698566DNAArtificial SequenceMutation 9 for LIGCas-3 locus
85aaggcgcaaa tgagtagcag cgcacgtata tatcctccgc cggggcacgt acggtacaat
60tcccag 668695DNAArtificial SequenceMutation 10 for LIGCas-3 locus
86aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtatgtg aggtatatat
60atcctccgcc ggggcacgta cggtacaatt cccag 958795DNAArtificial
SequenceMutation 1 for LIG3-4 homing endonuclease locus
87ccttcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacgtg aggtatatat
60atcctccgcc ggggcacgta cggtacaatt cccag 958868DNAArtificial
SequenceMutation 2 for LIG3-4 homing endonuclease locus
88ccttcgcaaa tgagtagcag cgcacgtata tatatcctcc gccggggcac gtacggtaca
60attcccag 688965DNAArtificial SequenceMutation 3 for LIG3-4 homing
endonuclease locus 89ccttcgcaaa tgagtagcag cgcacgtata tatacgcgta
cgcgtacgta cggtacaatt 60cccag 659055DNAArtificial SequenceMutation
4 for LIG3-4 homing endonuclease locus 90ccttcgcaaa tgagtagcag
cgcacgtata tatacgcgta cggtacaatt cccag 559169DNAArtificial
SequenceMutation 5 for LIG3-4 homing endonuclease locus
91ccttcgcaaa tgagtagcag cgcacgtata tatacgcgta cgccggggca cgtacggtac
60aattcccag 699285DNAArtificial SequenceMutation 6 for LIG3-4
homing endonuclease locus 92ccttcgcaaa tgagtagcag cgcacgtata
tatacgtgtg aggtatatat atcctccgcc 60ggggcacgta cggtacaatt cccag
859393DNAArtificial SequenceMutation 7 for LIG3-4 homing
endonuclease locus 93ccttcgcaaa tgagtagcag cgcacgtata tatacgcgta
cgcgtgtgag gtatatatat 60cctccgccgg ggcacgtacg gtacaattcc cag
939466DNAArtificial SequenceMutation 8 for LIG3-4 homing
endonuclease locus 94ccttcgcaaa tgagtagcag cgcacgtata tatcctccgc
cggggcacgt acggtacaat 60tcccag 669595DNAArtificial SequenceMutation
9 for LIG3-4 homing endonuclease locus 95ccttcgcaaa tgagtagcag
cgcacgtata tatacgcgta cgcgtacgtg tggtatatat 60atcctccgcc ggggcacgta
cggtacaatt cccag 9596102DNAArtificial SequenceMutation 10 for
LIG3-4 homing endonuclease locus 96ccttcgcaaa tgagtagcag cgcacgtata
tatacgcgta cggtatatat acgtgtgagg 60tatatatatc ctccgccggg gcacgtacgg
tacaattccc ag 102975424DNAArtificial Sequencedonor DNA -HR Repair
DNA 97cccatagaaa actgtgtgct ataatacacc aaaaggaaag caaagtgaaa
aggaaacttt 60gaatagccaa gaagactcgg agtgcttcac gccttcacct atcccacata
ggtgatgagc 120taagagtaaa atgtagattc tctcgagtac tgaatattgc
ctgcactttt ccttgcagta 180aatacacctt taatccatga cgagagtcca
ctctttgagt ccgtcttgag attcttccat 240tgatcataca acatgacctc
gaagtcctga tggagaacaa cttatataat taaaactaca 300atacagaaag
ttcctgacaa ttaaaacctt tggtggtggc atgccgtagg ttaaaaaaaa
360tagataatga caacacaact ggagacacgc tctttgccga gtgctcacac
gtttgctgag 420agcgagcact cggcaaatat atgatttgcc gaataccacc
ctcctcggca aaacaataca 480ctaggcaaaa aggtagtttc ccatcaccat
gatgcccgcc gttaatgtac cttctatgcc 540gagtatgttg gcgctcagca
aagagatcgt taccggcgtt tgtttcacca agagctcttt 600gacgagtgtg
gcacacgaca aaaccttttg ccgagtgtaa ttagtcgttt gccaagtgac
660tggtgcagtt ggcaaaggag tcgtttatta tgtgtgggca aaatgatata
tggtgccagt 720tagggctagc aaattaaagg gggggggggg ggggttaggt
tgaagaaggt gacgagtaat 780aaggtctcgg acggccgcgc gcatatatat
cagatccgat ccaatggcac acggtgcaaa 840cgaaaagcac gaaatttcca
ccagcttaat tagggagaga aaaatagagc accagctgat 900gagtgaatga
atgagataga cgggacacag agggtccagc aggctagcct actctggccg
960ccctaaatag aagtcagtgc cgtgacgacg cgcaaacttc ttttgatcgg
ctgcggaaat 1020aatatactgt aacgatttac gcacctgctg ggaattgtac
cgtacgtgcc ccggcggagg 1080atatatatac ctcacacaag ggcgaattgt
actagttagt tagctagtcg gtcctagatg 1140ccgtaatcat tagctaatcg
taagtgacgc ttggacacga gcggcttgag ctaggaacct 1200acgaagtcat
cggaatcagc tcaggtgtac agaagttcct atactttctg gagaatagga
1260acttcggaat aggaacttcg tatacgctag ggccgcattc gcaaaacaca
cctagactag 1320atttgttttg ctaacccaat tgatattaat tatatatgat
taatatttat atgtatatgg 1380atttggttaa tgaaatgcat ctggttcatc
aaagaattat aaagacacgt gacattcatt 1440taggataaga aatatggatg
atctctttct cttttattca gataactagt aattacacat 1500aacacacaac
tttgatgccc acattatagt gattagcatg tcactatgtg tgcatccttt
1560tatttcatac attaattaag ttggccaatc cagaagatgg acaagtctag
gtttcgactc 1620agatctgcgt caccgggcgc accgggcgcg gcggggccgg
cagctcgaag tcgcgctgcc 1680agaagccgac gtcgtgccag ccgccgtgct
tgtagccggc ggcgcggagg gtgccgcggg 1740cggtgtagcc gagggcctcg
tggaggcgca cggacgggtc gttcgggagg ccgatcacgg 1800ccaccacgga
cttgaagccc tgggcctcca tgctcttgag gaggtgggtg tagagggtgg
1860agccgaggcc gaggcgctgg tggcggtggg acacgtacac ggtggactcc
acggtccagt 1920cgtaggcgtt gcgggccttc cacgggccgg cgtaggcgat
gccggccacc acgccctcca 1980cctcggccac gagccacggg tagcggtcct
ggaggcgctc caggtcgtcg atccactcct 2040gcggggtctg cggctcggtg
cggaagttca cggtggaggt ctcgatgtag tggttcacga 2100tgtcgcacac
ggcggccatg tcggcggcgg tggccgggcg gatctcgacg gggcggcgct
2160cgggggacat ggtgtcgtgt ggatcccggt ggatctgaag ttcctatact
ttctagagaa 2220taggaacttc ggaataggaa cttcgctagc gaattgatcc
tctagagtcg acctgcagaa 2280gtaacaccaa acaacagggt gagcatcgac
aaaagaaaca gtaccaagca aataaatagc 2340gtatgaaggc agggctaaaa
aaatccacat atagctgctg catatgccat catccaagta 2400tatcaagatc
aaaataatta taaaacatac ttgtttatta taatagatag gtactcaagg
2460ttagagcata tgaatagatg ctgcatatgc catcatgtat atgcatcagt
aaaacccaca 2520tcaacatgta tacctatcct agatcgatat ttccatccat
cttaaactcg taactatgaa 2580gatgtatgac acacacatac agttccaaaa
ttaataaata caccaggtag tttgaaacag 2640tattctactc cgatctagaa
cgaatgaacg accgcccaac cacaccacat catcacaacc 2700aagcgaacaa
aaagcatctc tgtatatgca tcagtaaaac ccgcatcaac atgtatacct
2760atcctagatc gatatttcca tccatcatct tcaattcgta actatgaata
tgtatggcac 2820acacatacag atccaaaatt aataaatcca ccaggtagtt
tgaaacagaa ttctactccg 2880atctagaacg accgcccaac cagaccacat
catcacaacc aagacaaaaa aaagcatgaa 2940aagatgaccc gacaaacaag
tgcacggcat atattgaaat aaaggaaaag ggcaaaccaa 3000accctatgca
acgaaacaaa aaaaatcatg aaatcgatcc cgtctgcgga acggctagag
3060ccatcccagg attccccaaa gagaaacact ggcaagttag caatcagaac
gtgtctgacg 3120tacaggtcgc atccgtgtac gaacgctagc agcacggatc
taacacaaac acggatctaa 3180cacaaacatg aacagaagta gaactaccgg
gccctaacca tgcatggacc ggaacgccga 3240tctagagaag gtagagaggg
ggggggggga ggacgagcgg cgtaccttga agcggaggtg 3300ccgacgggtg
gatttggggg agatctggtt gtgtgtgtgt gcgctccgaa caacacgagg
3360ttggggaaag agggtgtgga gggggtgtct atttattacg gcgggcgagg
aagggaaagc 3420gaaggagcgg tgggaaagga atcccccgta gctgccggtg
ccgtgagagg aggaggaggc 3480cgcctgccgt gccggctcac gtctgccgct
ccgccacgca atttctggat gccgacagcg 3540gagcaagtcc aacggtggag
cggaactctc gagaggggtc cagaggcagc gacagagatg 3600ccgtgccgtc
tgcttcgctt ggcccgacgc gacgctgctg gttcgctggt tggtgtccgt
3660tagactcgtc gacggcgttt aacaggctgg cattatctac tcgaaacaag
aaaaatgttt 3720ccttagtttt tttaatttct taaagggtat ttgtttaatt
tttagtcact ttattttatt 3780ctattttata tctaaattat taaataaaaa
aactaaaata gagttttagt tttcttaatt 3840tagaggctaa aatagaataa
aatagatgta ctaaaaaaat tagtctataa aaaccattaa 3900ccctaaaccc
taaatggatg tactaataaa atggatgaag tattatatag gtgaagctat
3960ttgcaaaaaa aaaggagaac acatgcacac taaaaagata aaactgtaga
gtcctgttgt 4020caaaatactc aattgtcctt tagaccatgt ctaactgttc
atttatatga ttctctaaaa 4080cactgatatt attgtagtac tatagattat
attattcgta gagtaaagtt taaatatatg 4140tataaagata gataaactgc
acttcaaaca agtgtgacaa aaaaaatatg tggtaatttt 4200ttataactta
gacatgcaat gctcattatc tctagagagg ggcacgaccg ggtcacgctg
4260cactgcaggc tagcggcgaa ttcgcccttg tacgcgtacg cgtatatata
cgtgcgctgc 4320tactcatttg cgcgggaata cagctcagtc tgctgtgcgc
tgcaggatgt acatacatac 4380atgcgcaggt gcaaagtcta cgcgcgcggg
caatgcaagc ccctggcgta gttgggccat 4440gactgagatc acgcctcatg
gtcatggaac gaaacaccgc gtccggccgg gctgcccctg 4500gcgtcacgcg
ggaggcagct gctagcgtta gcgtacgtac ccaccgtctc gtacacacca
4560ccgcagggag agagaagagc gatgcaatgc acatgtacag catccgcatc
atgcatagat 4620actcatatct tcaaggccac acatgcagca gtgtcgtacg
ctacgttgtt tcaacggagg 4680aggaggatac atacatagac acccacagcc
agcctagcat atagcagata gcatacggac 4740tcccgggtga ggaaaaatgg
agggcgaacc aaaccaacca caaagaagca gcagcagcag 4800cagcagcagc
tgcggctgct atcaccactc accaactcca attaaagatc tctctctctc
4860tctctactgg ccggccctgt cagtgccagc gcccggtttg ttgctagctg
agctgcgggc 4920gtcgctctta gatatagccc aaaactcact ccaccaccac
tcgttccatg gaaccctaga 4980ccaaaagtac tcgcgctctc ggccctcgct
ctcgccctct ccctctccgc agcaaaagag 5040atccggccgg ccgagaaggg
cgcgcgctag ctgcccggct actagctggc gcccgcccgc 5100gcatatatct
gtgtcatcgc catcacccac accatggccc ggccggccaa caccgccgta
5160ttagctctgt ctgtcgctcg tccacctgcg accgactgag cgatcgatct
ccaccgagct 5220ctccgctaag cgctgtcctt gccgccgtcc tcccctccgt
cccctacgca tccatttccg 5280tgtgctcgtg tgtgcgcgcg cgggcactcc
tgctcctgct ccctccggcc cctcctcccc 5340tcccaggctc ccagctagcc
gcgcccgccc gcgcgacctg cacctgcaca gatcgggcgg 5400ccgggccgac
cgatcgatcg agat 54249824DNAArtificial SequenceForward PCR primer
98cccgttattg tatgaggtaa tgac 249931DNAArtificial SequenceReverse
PCR primer for site-specific transgene insertion at junction 1
99gctcgtgtcc aagcgtcact tacgattagc t 3110032DNAArtificial
SequenceForward PCR primer for site-specific transgene insertion at
junction 2 100ccatgtctaa ctgttcattt atatgattct ct
3210124DNAArtificial SequenceReverse PCR primer for site-specific
transgene insertion at junction 2 101gcagccgata ggttcatcat cttc
241027850DNAArtificial SequenceLinked Cas9 and LIGCas-3 long guide
RNA expression cassettes 102gtgcagcgtg acccggtcgt gcccctctct
agagataatg agcattgcat gtctaagtta 60taaaaaatta ccacatattt tttttgtcac
acttgtttga agtgcagttt atctatcttt 120atacatatat ttaaacttta
ctctacgaat aatataatct atagtactac aataatatca 180gtgttttaga
gaatcatata aatgaacagt tagacatggt ctaaaggaca attgagtatt
240ttgacaacag gactctacag ttttatcttt ttagtgtgca tgtgttctcc
tttttttttg 300caaatagctt cacctatata atacttcatc cattttatta
gtacatccat ttagggttta 360gggttaatgg tttttataga ctaatttttt
tagtacatct attttattct attttagcct 420ctaaattaag aaaactaaaa
ctctatttta gtttttttat ttaataattt agatataaaa 480tagaataaaa
taaagtgact aaaaattaaa caaataccct ttaagaaatt aaaaaaacta
540aggaaacatt tttcttgttt cgagtagata atgccagcct gttaaacgcc
gtcgacgagt 600ctaacggaca ccaaccagcg aaccagcagc gtcgcgtcgg
gccaagcgaa gcagacggca 660cggcatctct gtcgctgcct ctggacccct
ctcgagagtt ccgctccacc gttggacttg 720ctccgctgtc ggcatccaga
aattgcgtgg cggagcggca gacgtgagcc ggcacggcag 780gcggcctcct
cctcctctca cggcaccggc agctacgggg gattcctttc ccaccgctcc
840ttcgctttcc cttcctcgcc cgccgtaata aatagacacc ccctccacac
cctctttccc 900caacctcgtg ttgttcggag cgcacacaca cacaaccaga
tctcccccaa atccacccgt 960cggcacctcc gcttcaaggt acgccgctcg
tcctcccccc cccccctctc taccttctct 1020agatcggcgt tccggtccat
gcatggttag ggcccggtag ttctacttct gttcatgttt 1080gtgttagatc
cgtgtttgtg ttagatccgt gctgctagcg ttcgtacacg gatgcgacct
1140gtacgtcaga cacgttctga ttgctaactt gccagtgttt ctctttgggg
aatcctggga 1200tggctctagc cgttccgcag acgggatcga tttcatgatt
ttttttgttt cgttgcatag 1260ggtttggttt gcccttttcc tttatttcaa
tatatgccgt gcacttgttt gtcgggtcat 1320cttttcatgc ttttttttgt
cttggttgtg atgatgtggt ctggttgggc ggtcgttcta 1380gatcggagta
gaattctgtt tcaaactacc tggtggattt attaattttg gatctgtatg
1440tgtgtgccat acatattcat agttacgaat tgaagatgat ggatggaaat
atcgatctag 1500gataggtata catgttgatg cgggttttac tgatgcatat
acagagatgc tttttgttcg 1560cttggttgtg atgatgtggt gtggttgggc
ggtcgttcat tcgttctaga tcggagtaga 1620atactgtttc aaactacctg
gtgtatttat taattttgga actgtatgtg tgtgtcatac 1680atcttcatag
ttacgagttt aagatggatg gaaatatcga tctaggatag gtatacatgt
1740tgatgtgggt tttactgatg catatacatg atggcatatg cagcatctat
tcatatgctc 1800taaccttgag tacctatcta ttataataaa caagtatgtt
ttataattat tttgatcttg 1860atatacttgg atgatggcat atgcagcagc
tatatgtgga tttttttagc cctgccttca 1920tacgctattt atttgcttgg
tactgtttct tttgtcgatg ctcaccctgt tgtttggtgt 1980tacttctgca
ggtcgactct agaggatcca tggcaccgaa gaagaagcgc aaggtgatgg
2040acaagaagta cagcatcggc ctcgacatcg gcaccaactc ggtgggctgg
gccgtcatca 2100cggacgaata taaggtcccg tcgaagaagt tcaaggtcct
cggcaataca gaccgccaca 2160gcatcaagaa aaacttgatc ggcgccctcc
tgttcgatag cggcgagacc gcggaggcga 2220ccaggctcaa gaggaccgcc
aggagacggt acactaggcg caagaacagg atctgctacc 2280tgcaggagat
cttcagcaac gagatggcga aggtggacga ctccttcttc caccgcctgg
2340aggaatcatt cctggtggag gaggacaaga agcatgagcg gcacccaatc
ttcggcaaca 2400tcgtcgacga ggtaagtttc tgcttctacc tttgatatat
atataataat tatcattaat 2460tagtagtaat ataatatttc aaatattttt
ttcaaaataa aagaatgtag tatatagcaa 2520ttgcttttct gtagtttata
agtgtgtata ttttaattta taacttttct aatatatgac 2580caaaacatgg
tgatgtgcag gtggcctacc acgagaagta cccgacaatc taccacctcc
2640ggaagaaact ggtggacagc acagacaagg cggacctccg gctcatctac
cttgccctcg 2700cgcatatgat caagttccgc ggccacttcc tcatcgaggg
cgacctgaac ccggacaact 2760ccgacgtgga caagctgttc atccagctcg
tgcagacgta caatcaactg ttcgaggaga 2820accccataaa cgctagcggc
gtggacgcca aggccatcct ctcggccagg ctctcgaaat 2880caagaaggct
ggagaacctt atcgcgcagt tgccaggcga aaagaagaac ggcctcttcg
2940gcaaccttat tgcgctcagc ctcggcctga cgccgaactt caaatcaaac
ttcgacctcg 3000cggaggacgc caagctccag ctctcaaagg acacctacga
cgacgacctc gacaacctcc 3060tggcccagat aggagaccag tacgcggacc
tcttcctcgc cgccaagaac ctctccgacg 3120ctatcctgct cagcgacatc
cttcgggtca acaccgaaat taccaaggca ccgctgtccg 3180ccagcatgat
taaacgctac gacgagcacc atcaggacct cacgctgctc aaggcactcg
3240tccgccagca gctccccgag aagtacaagg agatcttctt cgaccaatca
aaaaacggct 3300acgcgggata tatcgacggc ggtgccagcc aggaagagtt
ctacaagttc atcaaaccaa 3360tcctggagaa gatggacggc accgaggagt
tgctggtcaa gctcaacagg gaggacctcc 3420tcaggaagca gaggaccttc
gacaacggct ccatcccgca tcagatccac ctgggcgaac 3480tgcatgccat
cctgcggcgc caggaggact tctacccgtt cctgaaggat aaccgggaga
3540agatcgagaa gatcttgacg ttccgcatcc catactacgt gggcccgctg
gctcgcggca 3600actcccggtt cgcctggatg acccggaagt cggaggagac
catcacaccc tggaactttg 3660aggaggtggt cgataagggc gctagcgctc
agagcttcat cgagcgcatg accaacttcg 3720ataaaaacct gcccaatgaa
aaagtcctcc ccaagcactc gctgctctac gagtacttca 3780ccgtgtacaa
cgagctcacc aaggtcaaat acgtcaccga gggcatgcgg aagccggcgt
3840tcctgagcgg cgagcagaag aaggcgatag tggacctcct cttcaagacc
aacaggaagg 3900tgaccgtgaa gcaattaaaa gaggactact tcaagaaaat
agagtgcttc gactccgtgg 3960agatctcggg cgtggaggat cggttcaacg
cctcactcgg cacgtatcac gacctcctca 4020agatcattaa agacaaggac
ttcctcgaca acgaggagaa cgaggacatc ctcgaggaca 4080tcgtcctcac
cctgaccctg ttcgaggacc gcgaaatgat cgaggagagg ctgaagacct
4140acgcgcacct gttcgacgac aaggtcatga aacagctcaa gaggcgccgc
tacactggtt 4200ggggaaggct gtcccgcaag ctcattaatg gcatcaggga
caagcagagc ggcaagacca 4260tcctggactt cctcaagtcc gacgggttcg
ccaaccgcaa cttcatgcag ctcattcacg 4320acgactcgct cacgttcaag
gaagacatcc agaaggcaca ggtgagcggg cagggtgact 4380ccctccacga
acacatcgcc aacctggccg gctcgccggc cattaaaaag ggcatcctgc
4440agacggtcaa ggtcgtcgac gagctcgtga aggtgatggg ccggcacaag
cccgaaaata 4500tcgtcataga gatggccagg gagaaccaga ccacccaaaa
agggcagaag aactcgcgcg 4560agcggatgaa acggatcgag gagggcatta
aagagctcgg gtcccagatc ctgaaggagc 4620accccgtgga aaatacccag
ctccagaatg aaaagctcta cctctactac ctgcagaacg 4680gccgcgacat
gtacgtggac caggagctgg acattaatcg gctatcggac tacgacgtcg
4740accacatcgt gccgcagtcg ttcctcaagg acgatagcat cgacaacaag
gtgctcaccc 4800ggtcggataa aaatcggggc aagagcgaca acgtgcccag
cgaggaggtc gtgaagaaga 4860tgaaaaacta ctggcgccag ctcctcaacg
cgaaactgat cacccagcgc aagttcgaca 4920acctgacgaa ggcggaacgc
ggtggcttga gcgaactcga taaggcgggc ttcataaaaa 4980ggcagctggt
cgagacgcgc cagatcacga agcatgtcgc ccagatcctg gacagccgca
5040tgaatactaa gtacgatgaa aacgacaagc tgatccggga ggtgaaggtg
atcacgctga 5100agtccaagct cgtgtcggac ttccgcaagg acttccagtt
ctacaaggtc cgcgagatca 5160acaactacca ccacgcccac gacgcctacc
tgaatgcggt ggtcgggacc gccctgatca 5220agaagtaccc gaagctggag
tcggagttcg tgtacggcga ctacaaggtc tacgacgtgc 5280gcaaaatgat
cgccaagtcc gagcaggaga tcggcaaggc cacggcaaaa tacttcttct
5340actcgaacat catgaacttc ttcaagaccg agatcaccct cgcgaacggc
gagatccgca 5400agcgcccgct catcgaaacc aacggcgaga cgggcgagat
cgtctgggat aagggccggg 5460atttcgcgac ggtccgcaag gtgctctcca
tgccgcaagt caatatcgtg aaaaagacgg 5520aggtccagac gggcgggttc
agcaaggagt ccatcctccc gaagcgcaac tccgacaagc 5580tcatcgcgag
gaagaaggat tgggacccga aaaaatatgg cggcttcgac agcccgaccg
5640tcgcatacag cgtcctcgtc gtggcgaagg tggagaaggg caagtcaaag
aagctcaagt 5700ccgtgaagga gctgctcggg atcacgatta tggagcggtc
ctccttcgag aagaacccga 5760tcgacttcct agaggccaag ggatataagg
aggtcaagaa ggacctgatt attaaactgc 5820cgaagtactc gctcttcgag
ctggaaaacg gccgcaagag gatgctcgcc tccgcaggcg 5880agttgcagaa
gggcaacgag ctcgccctcc cgagcaaata cgtcaatttc ctgtacctcg
5940ctagccacta tgaaaagctc aagggcagcc cggaggacaa cgagcagaag
cagctcttcg 6000tggagcagca caagcattac ctggacgaga tcatcgagca
gatcagcgag ttctcgaagc 6060gggtgatcct cgccgacgcg aacctggaca
aggtgctgtc ggcatataac aagcaccgcg 6120acaaaccaat acgcgagcag
gccgaaaata tcatccacct cttcaccctc accaacctcg 6180gcgctccggc
agccttcaag tacttcgaca ccacgattga ccggaagcgg tacacgagca
6240cgaaggaggt gctcgatgcg acgctgatcc accagagcat cacagggctc
tatgaaacac 6300gcatcgacct gagccagctg ggcggagaca agagaccacg
ggaccgccac gatggcgagc 6360tgggaggccg caagcgggca aggtaggtac
cgttaaccta gacttgtcca tcttctggat 6420tggccaactt aattaatgta
tgaaataaaa ggatgcacac atagtgacat gctaatcact 6480ataatgtggg
catcaaagtt gtgtgttatg tgtaattact agttatctga ataaaagaga
6540aagagatcat ccatatttct tatcctaaat gaatgtcacg tgtctttata
attctttgat 6600gaaccagatg catttcatta accaaatcca tatacatata
aatattaatc atatataatt 6660aatatcaatt gggttagcaa aacaaatcta
gtctaggtgt gttttgcgaa tgcggccccc 6720cctcgaggtc gacggtatcg
ataagctttg agagtacaat gatgaaccta gattaatcaa 6780tgccaaagtc
tgaaaaatgc accctcagtc tatgatccag aaaatcaaga ttgcttgagg
6840ccctgttcgg ttgttccgga ttagagcccc ggattaattc ctagccggat
tacttctcta 6900atttatatag attttgatga gctggaatga atcctggctt
attccggtac aaccgaacag 6960gccctgaagg ataccagtaa tcgctgagct
aaattggcat gctgtcagag tgtcagtatt 7020gcagcaaggt agtgagataa
ccggcatcat ggtgccagtt tgatggcacc attagggtta 7080gagatggtgg
ccatgggcgc atgtcctggc caactttgta tgatatatgg cagggtgaat
7140aggaaagtaa aattgtattg taaaaaggga tttcttctgt ttgttagcgc
atgtacaagg 7200aatgcaagtt ttgagcgagg gggcatcaaa gatctggctg
tgtttccagc tgtttttgtt 7260agccccatcg aatccttgac ataatgatcc
cgcttaaata agcaacctcg cttgtatagt 7320tccttgtgct ctaacacacg
atgatgataa gtcgtaaaat agtggtgtcc aaagaatttc 7380caggcccagt
tgtaaaagct aaaatgctat tcgaatttct actagcagta agtcgtgttt
7440agaaattatt tttttatata ccttttttcc ttctatgtac agtaggacac
agtgtcagcg 7500ccgcgttgac ggagaatatt tgcaaaaaag taaaagagaa
agtcatagcg gcgtatgtgc 7560caaaaacttc gtcacagaga gggccataag
aaacatggcc cacggcccaa tacgaagcac 7620cgcgacgaag cccaaacagc
agtccgtagg tggagcaaag cgctgggtaa tacgcaaacg 7680ttttgtccca
ccttgactaa tcacaagagt ggagcgtacc ttataaaccg agccgcaagc
7740accgaattgc gtacgcgtac gtgtggtttt agagctagaa atagcaagtt
aaaataaggc 7800tagtccgtta tcaacttgaa aaagtggcac cgagtcggtg
cttttttttt 785010323DNAZea mays 103tgggcaggtc tcacgacggt tgg
2310491DNAZea mays 104ccggtttcgc gtgctctggc tttacattac atgggcaggt
ctcacgacgg ttgggctgga 60gagccggctg gtaggggagg acctcaacgg c
9110590DNAArtificial SequenceMutation 1 for 55CasRNA-1 locus
105ccggtttcgc gtgctctggc tttacattac atgggcaggt ctcacgaggt
tgggctggag 60agccggctgg taggggagga cctcaacggc 9010690DNAArtificial
SequenceMutation 2 for 55CasRNA-1 locus 106ccggtttcgc gtgctctggc
tttacattac atgggcaggt ctcacacggt tgggctggag 60agccggctgg taggggagga
cctcaacggc 9010792DNAArtificial SequenceMutation 3 for 55CasRNA-1
locus 107ccggtttcgc gtgctctggc tttacattac atgggcaggt ctcacgacgg
tttgggctgg 60agagccggct ggtaggggag gacctcaacg gc
9210889DNAArtificial SequenceMutation 4 for 55CasRNA-1 locus
108ccggtttcgc gtgctctggc tttacattgc atgagcaggt cgtgacggtt
gggctggaga 60gccggctggt aggggaggac ctcaacggc 8910957DNAArtificial
SequenceMutation 5 for 55CasRNA-1 locus 109gggcaggtct cgacggttgg
gctggagagc cggctggtag gggaggacct caacggc 5711057DNAArtificial
SequenceMutation 6 for 55CasRNA-1 locus 110ccggtttcgc gtgctcttgg
gctggagagc cggctggtag gggaggacct caacggc 5711122DNAZea mays
111atatacctca cacgtacgcg ta 221121053DNAZea mays 112atgaacacca
agtacaacaa ggagttcctg ctctacctgg ccggcttcgt ggacggcgac 60ggctccatca
aggcgcagat caagccgaac cagtcctgca agttcaagca ccagctctcc
120ctgaccttcc aggtgaccca gaagacgcag aggcgctggt tcctcgacaa
gctggtcgac 180gagatcgggg tgggctacgt ctacgaccgc gggtcggtgt
ccgactacga gctctcccag 240atcaagcccc tgcacaactt cctcacccag
ctccagccgt tcctcaagct gaagcagaag 300caggcgaacc tcgtcctgaa
gatcatcgag cagctcccct cggccaagga gtccccggac 360aagttcctgg
aggtgtgcac gtgggtcgac cagatcgcgg ccctcaacga cagcaagacc
420cgcaagacga cctcggagac ggtgcgggcg gtcctggact ccctcccagg
atccgtggga 480ggtctatcgc catctcaggc atccagcgcc gcatcctcgg
cttcctcaag cccgggttca 540gggatctccg aagcactcag agctggagca
actaagtcca aggaattcct gctctacctg 600gccggcttcg tggacggcga
cggctccatc atcgcgtcca tcaagccgcg ccagtgctac 660aagttcaagc
acgagctccg cctggagttc accgtgaccc agaagacgca gaggcgctgg
720ttcctcgaca agctggtcga cgagatcggg gtgggctacg tctacgaccg
cgggtcggtg 780tccgactacc gcctctccca gatcaagccc ctgcacaact
tcctcaccca gctccagccg 840ttcctcaagc tgaagcagaa gcaggcgaac
ctcgtcctga agatcatcga gcagctcccc 900tcggccaagg agtccccgga
caagttcctg gaggtgtgca cgtgggtcga ccagatcgcg 960gccctcaacg
acagcaagac ccgcaagacg acctcggaga cggtgcgggc ggtcctggac
1020tccctcagcg agaagaagaa gtcgtccccc tga 105311322DNAZea mays
113gatggtgacg tacgtgccct ac 221141053DNAZea mays 114atgaacacca
agtacaacaa ggagttcctc ctctacctgg caggtttcgt ggacggcgat 60gggtctatca
tcgcccagat taccccgcaa cagtcctaca agttcaagca cgccctgcgg
120ctgaggttca cggtcactca gaagacgcag cgcaggtggt tcctcgataa
gctggtcgac 180gaaatcggag tcggcaaggt gcgggacagg ggctctgtca
gcgactacat cctctcccag 240aagaagccgc tccacaactt cctgacccag
ctgcagccct tcctcaagct caagcagaag 300caggccaacc tggtgctcaa
gatcatcgag cagctgccat ctgccaagga gtcaccagac 360aagttccttg
aggtctgcac ctgggtcgat cagatcgctg ccctgaacga ctccaagacg
420aggaagacca cctccgagac cgtcagggct gtgctggact cactcccagg
atccgttggc 480ggtctcagcc cttctcaggc tagctcggct gcttcctcag
ccagcagctc acctggctcc 540ggtatcagcg aggctctcag agcaggtgcc
accaagtcca aggagttcct cctgtacctg 600gcaggcttcg ttgacggcga
cggctcgatc atggcgtcca ttaccccgaa ccagtcgtgt 660aagttcaagc
atcagctgcg cctgcgcttt accgtcacgc agaagaccca gaggcgctgg
720ttcctggaca aactggtgga cgagatcggg gtcgggaagg tgtacgacag
agggagcgtt 780agcgactacc ggctgtccca gaagaagccg ctccacaact
tcctgacgca gctccaaccc 840ttcctgaagc tgaagcagaa gcaggcgaac
cttgtgctga agatcattga gcagctgccg 900agcgccaagg agagccctga
caagttcctg gaggtctgca cctgggtcga ccagatcgct 960gccctcaacg
actccaagac caggaagacc acgagcgaga ccgttcgggc tgtcctggac
1020agcctctccg agaagaagaa gtcgagcccg tag 10531154104DNAArtificial
sequencesoybean codon optimized Cas9 115atggacaaaa agtactcaat
agggctcgac atagggacta actccgttgg atgggccgtc 60atcaccgacg agtacaaggt
gccctccaag aagttcaagg tgttgggaaa caccgacagg 120cacagcataa
agaagaattt gatcggtgcc ctcctcttcg actccggaga gaccgctgag
180gctaccaggc tcaagaggac cgctagaagg cgctacacca gaaggaagaa
cagaatctgc 240tacctgcagg agatcttctc caacgagatg gccaaggtgg
acgactcctt cttccaccgc 300cttgaggaat cattcctggt ggaggaggat
aaaaagcacg agagacaccc aatcttcggg 360aacatcgtcg acgaggtggc
ctaccatgaa aagtacccta ccatctacca cctgaggaag 420aagctggtcg
actctaccga caaggctgac ttgcgcttga tttacctggc tctcgctcac
480atgataaagt tccgcggaca cttcctcatt gagggagacc tgaacccaga
caactccgac 540gtggacaagc tcttcatcca gctcgttcag acctacaacc
agcttttcga ggagaaccca 600atcaacgcca gtggagttga cgccaaggct
atcctctctg ctcgtctgtc aaagtccagg 660aggcttgaga acttgattgc
ccagctgcct ggcgaaaaga agaacggact gttcggaaac 720ttgatcgctc
tctccctggg attgactccc aacttcaagt ccaacttcga cctcgccgag
780gacgctaagt tgcagttgtc taaagacacc tacgacgatg acctcgacaa
cttgctggcc 840cagataggcg accaatacgc cgatctcttc ctcgccgcta
agaacttgtc cgacgcaatc 900ctgctgtccg acatcctgag agtcaacact
gagattacca aagctcctct gtctgcttcc 960atgattaagc gctacgacga
gcaccaccaa gatctgaccc tgctcaaggc cctggtgaga 1020cagcagctgc
ccgagaagta caaggagatc tttttcgacc agtccaagaa cggctacgcc
1080ggatacattg acggaggcgc ctcccaggaa gagttctaca agttcatcaa
gcccatcctt 1140gagaagatgg acggtaccga ggagctgttg gtgaagttga
acagagagga cctgttgagg 1200aagcagagaa ccttcgacaa cggaagcatc
cctcaccaaa tccacctggg agagctccac 1260gccatcttga ggaggcagga
ggatttctat cccttcctga aggacaaccg cgagaagatt 1320gagaagatct
tgaccttcag aattccttac tacgtcgggc cactcgccag aggaaactct
1380aggttcgcct ggatgacccg caaatctgaa gagaccatta ctccctggaa
cttcgaggaa 1440gtcgtggaca agggcgcttc cgctcagtct ttcatcgaga
ggatgaccaa cttcgataaa 1500aatctgccca acgagaaggt gctgcccaag
cactccctgt tgtacgagta tttcacagtg 1560tacaacgagc tcaccaaggt
gaagtacgtc acagagggaa tgaggaagcc tgccttcttg 1620tccggagagc
agaagaaggc catcgtcgac ctgctcttca agaccaacag gaaggtgact
1680gtcaagcagc tgaaggagga ctacttcaag aagatcgagt gcttcgactc
cgtcgagatc 1740tctggtgtcg aggacaggtt caacgcctcc cttgggactt
accacgatct gctcaagatt 1800attaaagaca aggacttcct ggacaacgag
gagaacgagg acatccttga ggacatcgtg 1860ctcaccctga ccttgttcga
agacagggaa atgatcgaag agaggctcaa gacctacgcc 1920cacctcttcg
acgacaaggt gatgaaacag ctgaagagac gcagatatac cggctgggga
1980aggctctccc gcaaattgat caacgggatc agggacaagc agtcagggaa
gactatactc 2040gacttcctga agtccgacgg attcgccaac aggaacttca
tgcagctcat tcacgacgac 2100tccttgacct tcaaggagga catccagaag
gctcaggtgt ctggacaggg tgactccttg 2160catgagcaca ttgctaactt
ggccggctct cccgctatta agaagggcat tttgcagacc 2220gtgaaggtcg
ttgacgagct cgtgaaggtg atgggacgcc acaagccaga gaacatcgtt
2280attgagatgg ctcgcgagaa ccaaactacc cagaaagggc agaagaattc
ccgcgagagg 2340atgaagcgca ttgaggaggg cataaaagag cttggctctc
agatcctcaa ggagcacccc 2400gtcgagaaca ctcagctgca gaacgagaag
ctgtacctgt actacctcca aaacggaagg 2460gacatgtacg tggaccagga
gctggacatc aacaggttgt ccgactacga cgtcgaccac 2520atcgtgcctc
agtccttcct gaaggatgac tccatcgaca ataaagtgct gacacgctcc
2580gataaaaata gaggcaagtc cgacaacgtc ccctccgagg aggtcgtgaa
gaagatgaaa 2640aactactgga gacagctctt gaacgccaag ctcatcaccc
agcgtaagtt cgacaacctg 2700actaaggctg agagaggagg attgtccgag
ctcgataagg ccggattcat caagagacag 2760ctcgtcgaaa cccgccaaat
taccaagcac gtggcccaaa ttctggattc ccgcatgaac 2820accaagtacg
atgaaaatga caagctgatc cgcgaggtca aggtgatcac cttgaagtcc
2880aagctggtct ccgacttccg caaggacttc cagttctaca aggtgaggga
gatcaacaac 2940taccaccacg cacacgacgc ctacctcaac gctgtcgttg
gaaccgccct catcaaaaaa 3000tatcctaagc tggagtctga gttcgtctac
ggcgactaca aggtgtacga cgtgaggaag 3060atgatcgcta agtctgagca
ggagatcggc aaggccaccg ccaagtactt cttctactcc 3120aacatcatga
acttcttcaa gaccgagatc actctcgcca acggtgagat caggaagcgc
3180ccactgatcg agaccaacgg tgagactgga gagatcgtgt gggacaaagg
gagggatttc 3240gctactgtga ggaaggtgct ctccatgcct caggtgaaca
tcgtcaagaa gaccgaagtt 3300cagaccggag gattctccaa ggagtccatc
ctccccaaga gaaactccga caagctgatc 3360gctagaaaga aagactggga
ccctaagaag tacggaggct tcgattctcc taccgtggcc 3420tactctgtgc
tggtcgtggc caaggtggag aagggcaagt ccaagaagct gaaatccgtc
3480aaggagctcc tcgggattac catcatggag aggagttcct tcgagaagaa
ccctatcgac 3540ttcctggagg ccaagggata taaagaggtg aagaaggacc
tcatcatcaa gctgcccaag 3600tactccctct tcgagttgga gaacggaagg
aagaggatgc tggcttctgc cggagagttg 3660cagaagggaa atgagctcgc
ccttccctcc aagtacgtga acttcctgta cctcgcctct 3720cactatgaaa
agttgaaggg ctctcctgag gacaacgagc agaagcagct cttcgtggag
3780cagcacaagc actacctgga cgaaattatc gagcagatct ctgagttctc
caagcgcgtg 3840atattggccg acgccaacct cgacaaggtg ctgtccgcct
acaacaagca cagggataag 3900cccattcgcg agcaggctga aaacattatc
cacctgttta ccctcacaaa cttgggagcc 3960cctgctgcct tcaagtactt
cgacaccacc attgacagga agagatacac ctccaccaag 4020gaggtgctcg
acgcaacact catccaccaa tccatcaccg gcctctatga aacaaggatt
4080gacttgtccc agctgggagg cgac 41041161503DNAGlycine max
116ccgggtttac ttattttgtg ggtatctata cttttattag atttttaatc
aggctcctga 60tttcttttta tttcgattga attcctgaac ttgtattatt cagtagatcg
aataaattat 120aaaaagataa aatcataaaa taatatttta tcctatcaat
catattaaag caatgaatat 180gtaaaattaa tcttatcttt attttaaaaa
atcatatagg tttagtattt ttttaaaaat 240aaagatagga ttagttttac
tattcactgc ttattacttt taaaaaaatc ataaaggttt 300agtatttttt
taaaataaat ataggaatag ttttactatt cactgcttta atagaaaaat
360agtttaaaat ttaagatagt tttaatccca gcatttgcca cgtttgaacg
tgagccgaaa 420cgatgtcgtt acattatctt aacctagctg aaacgatgtc
gtcataatat cgccaaatgc 480caactggact acgtcgaacc cacaaatccc
acaaagcgcg tgaaatcaaa tcgctcaaac 540cacaaaaaag aacaacgcgt
ttgttacacg ctcaatccca cgcgagtaga gcacagtaac 600cttcaaataa
gcgaatgggg cataatcaga aatccgaaat aaacctaggg gcattatcgg
660aaatgaaaag tagctcactc aatataaaaa tctaggaacc ctagttttcg
ttatcactct 720gtgctccctc gctctatttc tcagtctctg tgtttgcggc
tgaggattcc gaacgagtga 780ccttcttcgt ttctcgcaaa ggtaacagcc
tctgctcttg tctcttcgat tcgatctatg 840cctgtctctt atttacgatg
atgtttcttc ggttatgttt ttttatttat gctttatgct 900gttgatgttc
ggttgtttgt ttcgctttgt ttttgtggtt cagtttttta ggattctttt
960ggtttttgaa tcgattaatc ggaagagatt ttcgagttat ttggtgtgtt
ggaggtgaat 1020cttttttttg aggtcataga tctgttgtat ttgtgttata
aacatgcgac tttgtatgat 1080tttttacgag gttatgatgt tctggttgtt
ttattatgaa tctgttgaga cagaaccatg 1140atttttgttg atgttcgttt
acactattaa aggtttgttt taacaggatt aaaagttttt 1200taagcatgtt
gaaggagtct tgtagatatg taaccgtcga tagttttttt gtgggtttgt
1260tcacatgtta tcaagcttaa tcttttacta tgtatgcgac catatctgga
tccagcaaag 1320gcgatttttt aattccttgt gaaacttttg taatatgaag
ttgaaatttt gttattggta 1380aactataaat gtgtgaagtt ggagtatacc
tttaccttct tatttggctt tgtgatagtt 1440taatttatat gtattttgag
ttctgacttg tatttctttg aattgattct agtttaagta 1500atc
150311733DNAArtificial sequencelinker SV40 NLS 117tctagagccg
atcccaagaa gaagagaaag gtg 331181379PRTArtificial sequenceCas9 with
a SV40 NLS 118Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr
Asn Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val
Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His
Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser
Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg
Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln
Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe
Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105
110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr
115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu
Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu
Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu
Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys
Leu Phe Ile Gln Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu
Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile
Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu
Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230
235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn
Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp
Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly
Asp Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser
Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu
Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg
Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu
Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350
Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355
360 365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met
Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp
Leu Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile
Pro His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg
Arg Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu
Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val
Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr
Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475
480 Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr
485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys
His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu
Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala
Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu
Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys
Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu
Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr
Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600
605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr
610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr
Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu
Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys
Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile
Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe
Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp
Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720
His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725
730 735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met
Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg
Glu Asn Gln 755 760 765 Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu
Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser
Gln Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gln Leu
Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gln Asn Gly Arg
Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser
Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 835 840 845
Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850
855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met
Lys 865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile
Thr Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly
Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gln
Leu Val Glu Thr Arg Gln Ile Thr 915 920 925 Lys His Val Ala Gln Ile
Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn Asp Lys
Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945 950 955 960 Lys
Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 965 970
975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val
980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser
Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg
Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gln Glu Ile Gly Lys Ala
Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met Asn Phe
Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu Ile Arg
Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr Gly Glu
Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 Arg
Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr 1085 1090
1095 Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys
1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp
Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val
Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu Lys Gly
Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu Leu Gly
Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Phe Glu Lys Asn Pro
Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180 1185 Glu Val Lys
Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 1190 1195 1200 Phe
Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly 1205 1210
1215 Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val
1220 1225 1230 Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys
Gly Ser 1235 1240 1245 Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val
Glu Gln His Lys 1250 1255 1260 His Tyr Leu Asp Glu Ile Ile Glu Gln
Ile Ser Glu Phe Ser Lys 1265 1270 1275 Arg Val Ile Leu Ala Asp Ala
Asn Leu Asp Lys Val Leu Ser Ala 1280 1285 1290 Tyr Asn Lys His Arg
Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 Ile Ile His
Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315 1320 Phe
Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser 1325 1330
1335 Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr
1340 1345 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly
Gly Asp 1355 1360 1365 Ser Arg Ala Asp Pro Lys Lys Lys Arg Lys Val
1370 1375 1198519DNAArtificial sequenceQC782 119ccgggtttac
ttattttgtg ggtatctata cttttattag atttttaatc aggctcctga 60tttcttttta
tttcgattga attcctgaac ttgtattatt cagtagatcg aataaattat
120aaaaagataa aatcataaaa taatatttta tcctatcaat catattaaag
caatgaatat 180gtaaaattaa tcttatcttt attttaaaaa atcatatagg
tttagtattt ttttaaaaat 240aaagatagga ttagttttac tattcactgc
ttattacttt taaaaaaatc ataaaggttt 300agtatttttt taaaataaat
ataggaatag ttttactatt cactgcttta atagaaaaat 360agtttaaaat
ttaagatagt tttaatccca gcatttgcca cgtttgaacg tgagccgaaa
420cgatgtcgtt acattatctt aacctagctg aaacgatgtc gtcataatat
cgccaaatgc 480caactggact acgtcgaacc cacaaatccc acaaagcgcg
tgaaatcaaa tcgctcaaac 540cacaaaaaag aacaacgcgt ttgttacacg
ctcaatccca cgcgagtaga gcacagtaac 600cttcaaataa gcgaatgggg
cataatcaga aatccgaaat aaacctaggg gcattatcgg 660aaatgaaaag
tagctcactc aatataaaaa tctaggaacc ctagttttcg ttatcactct
720gtgctccctc gctctatttc tcagtctctg tgtttgcggc tgaggattcc
gaacgagtga 780ccttcttcgt ttctcgcaaa ggtaacagcc tctgctcttg
tctcttcgat tcgatctatg 840cctgtctctt atttacgatg atgtttcttc
ggttatgttt ttttatttat gctttatgct 900gttgatgttc ggttgtttgt
ttcgctttgt ttttgtggtt cagtttttta ggattctttt 960ggtttttgaa
tcgattaatc ggaagagatt ttcgagttat ttggtgtgtt ggaggtgaat
1020cttttttttg aggtcataga tctgttgtat ttgtgttata aacatgcgac
tttgtatgat 1080tttttacgag gttatgatgt tctggttgtt
ttattatgaa tctgttgaga cagaaccatg 1140atttttgttg atgttcgttt
acactattaa aggtttgttt taacaggatt aaaagttttt 1200taagcatgtt
gaaggagtct tgtagatatg taaccgtcga tagttttttt gtgggtttgt
1260tcacatgtta tcaagcttaa tcttttacta tgtatgcgac catatctgga
tccagcaaag 1320gcgatttttt aattccttgt gaaacttttg taatatgaag
ttgaaatttt gttattggta 1380aactataaat gtgtgaagtt ggagtatacc
tttaccttct tatttggctt tgtgatagtt 1440taatttatat gtattttgag
ttctgacttg tatttctttg aattgattct agtttaagta 1500atccatggac
aaaaagtact caatagggct cgacataggg actaactccg ttggatgggc
1560cgtcatcacc gacgagtaca aggtgccctc caagaagttc aaggtgttgg
gaaacaccga 1620caggcacagc ataaagaaga atttgatcgg tgccctcctc
ttcgactccg gagagaccgc 1680tgaggctacc aggctcaaga ggaccgctag
aaggcgctac accagaagga agaacagaat 1740ctgctacctg caggagatct
tctccaacga gatggccaag gtggacgact ccttcttcca 1800ccgccttgag
gaatcattcc tggtggagga ggataaaaag cacgagagac acccaatctt
1860cgggaacatc gtcgacgagg tggcctacca tgaaaagtac cctaccatct
accacctgag 1920gaagaagctg gtcgactcta ccgacaaggc tgacttgcgc
ttgatttacc tggctctcgc 1980tcacatgata aagttccgcg gacacttcct
cattgaggga gacctgaacc cagacaactc 2040cgacgtggac aagctcttca
tccagctcgt tcagacctac aaccagcttt tcgaggagaa 2100cccaatcaac
gccagtggag ttgacgccaa ggctatcctc tctgctcgtc tgtcaaagtc
2160caggaggctt gagaacttga ttgcccagct gcctggcgaa aagaagaacg
gactgttcgg 2220aaacttgatc gctctctccc tgggattgac tcccaacttc
aagtccaact tcgacctcgc 2280cgaggacgct aagttgcagt tgtctaaaga
cacctacgac gatgacctcg acaacttgct 2340ggcccagata ggcgaccaat
acgccgatct cttcctcgcc gctaagaact tgtccgacgc 2400aatcctgctg
tccgacatcc tgagagtcaa cactgagatt accaaagctc ctctgtctgc
2460ttccatgatt aagcgctacg acgagcacca ccaagatctg accctgctca
aggccctggt 2520gagacagcag ctgcccgaga agtacaagga gatctttttc
gaccagtcca agaacggcta 2580cgccggatac attgacggag gcgcctccca
ggaagagttc tacaagttca tcaagcccat 2640ccttgagaag atggacggta
ccgaggagct gttggtgaag ttgaacagag aggacctgtt 2700gaggaagcag
agaaccttcg acaacggaag catccctcac caaatccacc tgggagagct
2760ccacgccatc ttgaggaggc aggaggattt ctatcccttc ctgaaggaca
accgcgagaa 2820gattgagaag atcttgacct tcagaattcc ttactacgtc
gggccactcg ccagaggaaa 2880ctctaggttc gcctggatga cccgcaaatc
tgaagagacc attactccct ggaacttcga 2940ggaagtcgtg gacaagggcg
cttccgctca gtctttcatc gagaggatga ccaacttcga 3000taaaaatctg
cccaacgaga aggtgctgcc caagcactcc ctgttgtacg agtatttcac
3060agtgtacaac gagctcacca aggtgaagta cgtcacagag ggaatgagga
agcctgcctt 3120cttgtccgga gagcagaaga aggccatcgt cgacctgctc
ttcaagacca acaggaaggt 3180gactgtcaag cagctgaagg aggactactt
caagaagatc gagtgcttcg actccgtcga 3240gatctctggt gtcgaggaca
ggttcaacgc ctcccttggg acttaccacg atctgctcaa 3300gattattaaa
gacaaggact tcctggacaa cgaggagaac gaggacatcc ttgaggacat
3360cgtgctcacc ctgaccttgt tcgaagacag ggaaatgatc gaagagaggc
tcaagaccta 3420cgcccacctc ttcgacgaca aggtgatgaa acagctgaag
agacgcagat ataccggctg 3480gggaaggctc tcccgcaaat tgatcaacgg
gatcagggac aagcagtcag ggaagactat 3540actcgacttc ctgaagtccg
acggattcgc caacaggaac ttcatgcagc tcattcacga 3600cgactccttg
accttcaagg aggacatcca gaaggctcag gtgtctggac agggtgactc
3660cttgcatgag cacattgcta acttggccgg ctctcccgct attaagaagg
gcattttgca 3720gaccgtgaag gtcgttgacg agctcgtgaa ggtgatggga
cgccacaagc cagagaacat 3780cgttattgag atggctcgcg agaaccaaac
tacccagaaa gggcagaaga attcccgcga 3840gaggatgaag cgcattgagg
agggcataaa agagcttggc tctcagatcc tcaaggagca 3900ccccgtcgag
aacactcagc tgcagaacga gaagctgtac ctgtactacc tccaaaacgg
3960aagggacatg tacgtggacc aggagctgga catcaacagg ttgtccgact
acgacgtcga 4020ccacatcgtg cctcagtcct tcctgaagga tgactccatc
gacaataaag tgctgacacg 4080ctccgataaa aatagaggca agtccgacaa
cgtcccctcc gaggaggtcg tgaagaagat 4140gaaaaactac tggagacagc
tcttgaacgc caagctcatc acccagcgta agttcgacaa 4200cctgactaag
gctgagagag gaggattgtc cgagctcgat aaggccggat tcatcaagag
4260acagctcgtc gaaacccgcc aaattaccaa gcacgtggcc caaattctgg
attcccgcat 4320gaacaccaag tacgatgaaa atgacaagct gatccgcgag
gtcaaggtga tcaccttgaa 4380gtccaagctg gtctccgact tccgcaagga
cttccagttc tacaaggtga gggagatcaa 4440caactaccac cacgcacacg
acgcctacct caacgctgtc gttggaaccg ccctcatcaa 4500aaaatatcct
aagctggagt ctgagttcgt ctacggcgac tacaaggtgt acgacgtgag
4560gaagatgatc gctaagtctg agcaggagat cggcaaggcc accgccaagt
acttcttcta 4620ctccaacatc atgaacttct tcaagaccga gatcactctc
gccaacggtg agatcaggaa 4680gcgcccactg atcgagacca acggtgagac
tggagagatc gtgtgggaca aagggaggga 4740tttcgctact gtgaggaagg
tgctctccat gcctcaggtg aacatcgtca agaagaccga 4800agttcagacc
ggaggattct ccaaggagtc catcctcccc aagagaaact ccgacaagct
4860gatcgctaga aagaaagact gggaccctaa gaagtacgga ggcttcgatt
ctcctaccgt 4920ggcctactct gtgctggtcg tggccaaggt ggagaagggc
aagtccaaga agctgaaatc 4980cgtcaaggag ctcctcggga ttaccatcat
ggagaggagt tccttcgaga agaaccctat 5040cgacttcctg gaggccaagg
gatataaaga ggtgaagaag gacctcatca tcaagctgcc 5100caagtactcc
ctcttcgagt tggagaacgg aaggaagagg atgctggctt ctgccggaga
5160gttgcagaag ggaaatgagc tcgcccttcc ctccaagtac gtgaacttcc
tgtacctcgc 5220ctctcactat gaaaagttga agggctctcc tgaggacaac
gagcagaagc agctcttcgt 5280ggagcagcac aagcactacc tggacgaaat
tatcgagcag atctctgagt tctccaagcg 5340cgtgatattg gccgacgcca
acctcgacaa ggtgctgtcc gcctacaaca agcacaggga 5400taagcccatt
cgcgagcagg ctgaaaacat tatccacctg tttaccctca caaacttggg
5460agcccctgct gccttcaagt acttcgacac caccattgac aggaagagat
acacctccac 5520caaggaggtg ctcgacgcaa cactcatcca ccaatccatc
accggcctct atgaaacaag 5580gattgacttg tcccagctgg gaggcgactc
tagagccgat cccaagaaga agagaaaggt 5640gtaggttaac ctagacttgt
ccatcttctg gattggccaa cttaattaat gtatgaaata 5700aaaggatgca
cacatagtga catgctaatc actataatgt gggcatcaaa gttgtgtgtt
5760atgtgtaatt actagttatc tgaataaaag agaaagagat catccatatt
tcttatccta 5820aatgaatgtc acgtgtcttt ataattcttt gatgaaccag
atgcatttca ttaaccaaat 5880ccatatacat ataaatatta atcatatata
attaatatca attgggttag caaaacaaat 5940ctagtctagg tgtgttttgc
gaatgcggcc gctcgagggg gggcccggta ccggcgcgcc 6000gttctatagt
gtcacctaaa tcgtatgtgt atgatacata aggttatgta ttaattgtag
6060ccgcgttcta acgacaatat gtccatatgg tgcactctca gtacaatctg
ctctgatgcc 6120gcatagttaa gccagccccg acacccgcca acacccgctg
acgcgccctg acgggcttgt 6180ctgctcccgg catccgctta cagacaagct
gtgaccgtct ccgggagctg catgtgtcag 6240aggttttcac cgtcatcacc
gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt 6300ttataggtta
atgtcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca
6360gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg
cgtaatctgc 6420tgcttgcaaa caaaaaaacc accgctacca gcggtggttt
gtttgccgga tcaagagcta 6480ccaactcttt ttccgaaggt aactggcttc
agcagagcgc agataccaaa tactgtcctt 6540ctagtgtagc cgtagttagg
ccaccacttc aagaactctg tagcaccgcc tacatacctc 6600gctctgctaa
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg
6660ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac
ggggggttcg 6720tgcacacagc ccagcttgga gcgaacgacc tacaccgaac
tgagatacct acagcgtgag 6780cattgagaaa gcgccacgct tcccgaaggg
agaaaggcgg acaggtatcc ggtaagcggc 6840agggtcggaa caggagagcg
cacgagggag cttccagggg gaaacgcctg gtatctttat 6900agtcctgtcg
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg
6960gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct
ggccttttgc 7020tggccttttg ctcacatgtt ctttcctgcg ttatcccctg
attctgtgga taaccgtatt 7080accgcctttg agtgagctga taccgctcgc
cgcagccgaa cgaccgagcg cagcgagtca 7140gtgagcgagg aagcggaaga
gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg 7200attcattaat
gcaggttgat cagatctcga tcccgcgaaa ttaatacgac tcactatagg
7260gagaccacaa cggtttccct ctagaaataa ttttgtttaa ctttaagaag
gagatatacc 7320catggaaaag cctgaactca ccgcgacgtc tgtcgagaag
tttctgatcg aaaagttcga 7380cagcgtctcc gacctgatgc agctctcgga
gggcgaagaa tctcgtgctt tcagcttcga 7440tgtaggaggg cgtggatatg
tcctgcgggt aaatagctgc gccgatggtt tctacaaaga 7500tcgttatgtt
tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat
7560tggggaattc agcgagagcc tgacctattg catctcccgc cgtgcacagg
gtgtcacgtt 7620gcaagacctg cctgaaaccg aactgcccgc tgttctgcag
ccggtcgcgg aggctatgga 7680tgcgatcgct gcggccgatc ttagccagac
gagcgggttc ggcccattcg gaccgcaagg 7740aatcggtcaa tacactacat
ggcgtgattt catatgcgcg attgctgatc cccatgtgta 7800tcactggcaa
actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga
7860gctgatgctt tgggccgagg actgccccga agtccggcac ctcgtgcacg
cggatttcgg 7920ctccaacaat gtcctgacgg acaatggccg cataacagcg
gtcattgact ggagcgaggc 7980gatgttcggg gattcccaat acgaggtcgc
caacatcttc ttctggaggc cgtggttggc 8040ttgtatggag cagcagacgc
gctacttcga gcggaggcat ccggagcttg caggatcgcc 8100gcggctccgg
gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga
8160cggcaatttc gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg
tccgatccgg 8220agccgggact gtcgggcgta cacaaatcgc ccgcagaagc
gcggccgtct ggaccgatgg 8280ctgtgtagaa gtactcgccg atagtggaaa
ccgacgcccc agcactcgtc cgagggcaaa 8340ggaatagtga ggtacagctt
ggatcgatcc ggctgctaac aaagcccgaa aggaagctga 8400gttggctgct
gccaccgctg agcaataact agcataaccc cttggggcct ctaaacgggt
8460cttgaggggt tttttgctga aaggaggaac tatatccgga tgatcgggcg
cgccggtac 8519120434DNAGlycine max 120ccgggtgtga tttagtataa
agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta 60cctagtaata agtaatattg
aacaaaataa atggtaaagt gtcagatata taaaataggc 120tttaataaaa
ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt
180catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat
acattaaaaa 240atacttggat ctttctctta ccctgtttat attgagacct
gaaacttgag agagatacac 300taatcttgcc ttgttgtttc attccctaac
ttacaggact cagcgcatgt catgtggtct 360cgttccccat ttaagtccca
caccgtctaa acttattaaa ttattaatgt ttataactag 420atgcacaaca acaa
434121104DNAArtificial sequenceGuide RNA for DD43CR1 121gtcccttgta
cttgtacgta gttttagagc tagaaatagc aagttaaaat aaggctagtc 60cgttatcaac
ttgaaaaagt ggcaccgagt cggtgctttt tttt 1041223098DNAArtificial
sequenceQC783 122ccgggtgtga tttagtataa agtgaagtaa tggtcaaaag
aaaaagtgta aaacgaagta 60cctagtaata agtaatattg aacaaaataa atggtaaagt
gtcagatata taaaataggc 120tttaataaaa ggaagaaaaa aaacaaacaa
aaaataggtt gcaatggggc agagcagagt 180catcatgaag ctagaaaggc
taccgataga taaactatag ttaattaaat acattaaaaa 240atacttggat
ctttctctta ccctgtttat attgagacct gaaacttgag agagatacac
300taatcttgcc ttgttgtttc attccctaac ttacaggact cagcgcatgt
catgtggtct 360cgttccccat ttaagtccca caccgtctaa acttattaaa
ttattaatgt ttataactag 420atgcacaaca acaaagcttg tcccttgtac
ttgtacgtag ttttagagct agaaatagca 480agttaaaata aggctagtcc
gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt 540tttgcggccg
ctcgaggggg ggcccggtac cggcgcgccg ttctatagtg tcacctaaat
600cgtatgtgta tgatacataa ggttatgtat taattgtagc cgcgttctaa
cgacaatatg 660tccatatggt gcactctcag tacaatctgc tctgatgccg
catagttaag ccagccccga 720cacccgccaa cacccgctga cgcgccctga
cgggcttgtc tgctcccggc atccgcttac 780agacaagctg tgaccgtctc
cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg 840aaacgcgcga
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgacc
900aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga
aaagatcaaa 960ggatcttctt gagatccttt ttttctgcgc gtaatctgct
gcttgcaaac aaaaaaacca 1020ccgctaccag cggtggtttg tttgccggat
caagagctac caactctttt tccgaaggta 1080actggcttca gcagagcgca
gataccaaat actgtccttc tagtgtagcc gtagttaggc 1140caccacttca
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca
1200gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag
acgatagtta 1260ccggataagg cgcagcggtc gggctgaacg gggggttcgt
gcacacagcc cagcttggag 1320cgaacgacct acaccgaact gagataccta
cagcgtgagc attgagaaag cgccacgctt 1380cccgaaggga gaaaggcgga
caggtatccg gtaagcggca gggtcggaac aggagagcgc 1440acgagggagc
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac
1500ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct
atggaaaaac 1560gccagcaacg cggccttttt acggttcctg gccttttgct
ggccttttgc tcacatgttc 1620tttcctgcgt tatcccctga ttctgtggat
aaccgtatta ccgcctttga gtgagctgat 1680accgctcgcc gcagccgaac
gaccgagcgc agcgagtcag tgagcgagga agcggaagag 1740cgcccaatac
gcaaaccgcc tctccccgcg cgttggccga ttcattaatg caggttgatc
1800agatctcgat cccgcgaaat taatacgact cactataggg agaccacaac
ggtttccctc 1860tagaaataat tttgtttaac tttaagaagg agatataccc
atggaaaagc ctgaactcac 1920cgcgacgtct gtcgagaagt ttctgatcga
aaagttcgac agcgtctccg acctgatgca 1980gctctcggag ggcgaagaat
ctcgtgcttt cagcttcgat gtaggagggc gtggatatgt 2040cctgcgggta
aatagctgcg ccgatggttt ctacaaagat cgttatgttt atcggcactt
2100tgcatcggcc gcgctcccga ttccggaagt gcttgacatt ggggaattca
gcgagagcct 2160gacctattgc atctcccgcc gtgcacaggg tgtcacgttg
caagacctgc ctgaaaccga 2220actgcccgct gttctgcagc cggtcgcgga
ggctatggat gcgatcgctg cggccgatct 2280tagccagacg agcgggttcg
gcccattcgg accgcaagga atcggtcaat acactacatg 2340gcgtgatttc
atatgcgcga ttgctgatcc ccatgtgtat cactggcaaa ctgtgatgga
2400cgacaccgtc agtgcgtccg tcgcgcaggc tctcgatgag ctgatgcttt
gggccgagga 2460ctgccccgaa gtccggcacc tcgtgcacgc ggatttcggc
tccaacaatg tcctgacgga 2520caatggccgc ataacagcgg tcattgactg
gagcgaggcg atgttcgggg attcccaata 2580cgaggtcgcc aacatcttct
tctggaggcc gtggttggct tgtatggagc agcagacgcg 2640ctacttcgag
cggaggcatc cggagcttgc aggatcgccg cggctccggg cgtatatgct
2700ccgcattggt cttgaccaac tctatcagag cttggttgac ggcaatttcg
atgatgcagc 2760ttgggcgcag ggtcgatgcg acgcaatcgt ccgatccgga
gccgggactg tcgggcgtac 2820acaaatcgcc cgcagaagcg cggccgtctg
gaccgatggc tgtgtagaag tactcgccga 2880tagtggaaac cgacgcccca
gcactcgtcc gagggcaaag gaatagtgag gtacagcttg 2940gatcgatccg
gctgctaaca aagcccgaaa ggaagctgag ttggctgctg ccaccgctga
3000gcaataacta gcataacccc ttggggcctc taaacgggtc ttgaggggtt
ttttgctgaa 3060aggaggaact atatccggat gatcgggcgc gccggtac
30981239093DNAArtificial sequenceQC815 123ccgggtgtga tttagtataa
agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta 60cctagtaata agtaatattg
aacaaaataa atggtaaagt gtcagatata taaaataggc 120tttaataaaa
ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt
180catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat
acattaaaaa 240atacttggat ctttctctta ccctgtttat attgagacct
gaaacttgag agagatacac 300taatcttgcc ttgttgtttc attccctaac
ttacaggact cagcgcatgt catgtggtct 360cgttccccat ttaagtccca
caccgtctaa acttattaaa ttattaatgt ttataactag 420atgcacaaca
acaaagcttg tcccttgtac ttgtacgtag ttttagagct agaaatagca
480agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc
ggtgcttttt 540tttgcggccg caattggatc gggtttactt attttgtggg
tatctatact tttattagat 600ttttaatcag gctcctgatt tctttttatt
tcgattgaat tcctgaactt gtattattca 660gtagatcgaa taaattataa
aaagataaaa tcataaaata atattttatc ctatcaatca 720tattaaagca
atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt
780tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt
attactttta 840aaaaaatcat aaaggtttag tattttttta aaataaatat
aggaatagtt ttactattca 900ctgctttaat agaaaaatag tttaaaattt
aagatagttt taatcccagc atttgccacg 960tttgaacgtg agccgaaacg
atgtcgttac attatcttaa cctagctgaa acgatgtcgt 1020cataatatcg
ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg
1080aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct
caatcccacg 1140cgagtagagc acagtaacct tcaaataagc gaatggggca
taatcagaaa tccgaaataa 1200acctaggggc attatcggaa atgaaaagta
gctcactcaa tataaaaatc taggaaccct 1260agttttcgtt atcactctgt
gctccctcgc tctatttctc agtctctgtg tttgcggctg 1320aggattccga
acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc
1380tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg
ttatgttttt 1440ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt
cgctttgttt ttgtggttca 1500gttttttagg attcttttgg tttttgaatc
gattaatcgg aagagatttt cgagttattt 1560ggtgtgttgg aggtgaatct
tttttttgag gtcatagatc tgttgtattt gtgttataaa 1620catgcgactt
tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc
1680tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag
gtttgtttta 1740acaggattaa aagtttttta agcatgttga aggagtcttg
tagatatgta accgtcgata 1800gtttttttgt gggtttgttc acatgttatc
aagcttaatc ttttactatg tatgcgacca 1860tatctggatc cagcaaaggc
gattttttaa ttccttgtga aacttttgta atatgaagtt 1920gaaattttgt
tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta
1980tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta
tttctttgaa 2040ttgattctag tttaagtaat ccatggacaa aaagtactca
atagggctcg acatagggac 2100taactccgtt ggatgggccg tcatcaccga
cgagtacaag gtgccctcca agaagttcaa 2160ggtgttggga aacaccgaca
ggcacagcat aaagaagaat ttgatcggtg ccctcctctt 2220cgactccgga
gagaccgctg aggctaccag gctcaagagg accgctagaa ggcgctacac
2280cagaaggaag aacagaatct gctacctgca ggagatcttc tccaacgaga
tggccaaggt 2340ggacgactcc ttcttccacc gccttgagga atcattcctg
gtggaggagg ataaaaagca 2400cgagagacac ccaatcttcg ggaacatcgt
cgacgaggtg gcctaccatg aaaagtaccc 2460taccatctac cacctgagga
agaagctggt cgactctacc gacaaggctg acttgcgctt 2520gatttacctg
gctctcgctc acatgataaa gttccgcgga cacttcctca ttgagggaga
2580cctgaaccca gacaactccg acgtggacaa gctcttcatc cagctcgttc
agacctacaa 2640ccagcttttc gaggagaacc caatcaacgc cagtggagtt
gacgccaagg ctatcctctc 2700tgctcgtctg tcaaagtcca ggaggcttga
gaacttgatt gcccagctgc ctggcgaaaa 2760gaagaacgga ctgttcggaa
acttgatcgc tctctccctg ggattgactc ccaacttcaa 2820gtccaacttc
gacctcgccg aggacgctaa gttgcagttg tctaaagaca cctacgacga
2880tgacctcgac aacttgctgg cccagatagg cgaccaatac gccgatctct
tcctcgccgc 2940taagaacttg tccgacgcaa tcctgctgtc cgacatcctg
agagtcaaca ctgagattac 3000caaagctcct ctgtctgctt ccatgattaa
gcgctacgac gagcaccacc aagatctgac 3060cctgctcaag gccctggtga
gacagcagct gcccgagaag tacaaggaga tctttttcga 3120ccagtccaag
aacggctacg ccggatacat tgacggaggc gcctcccagg aagagttcta
3180caagttcatc aagcccatcc ttgagaagat ggacggtacc gaggagctgt
tggtgaagtt 3240gaacagagag gacctgttga ggaagcagag aaccttcgac
aacggaagca tccctcacca 3300aatccacctg ggagagctcc acgccatctt
gaggaggcag gaggatttct atcccttcct 3360gaaggacaac cgcgagaaga
ttgagaagat cttgaccttc agaattcctt actacgtcgg 3420gccactcgcc
agaggaaact ctaggttcgc ctggatgacc cgcaaatctg aagagaccat
3480tactccctgg aacttcgagg aagtcgtgga caagggcgct tccgctcagt
ctttcatcga 3540gaggatgacc aacttcgata aaaatctgcc caacgagaag
gtgctgccca agcactccct 3600gttgtacgag tatttcacag tgtacaacga
gctcaccaag gtgaagtacg tcacagaggg 3660aatgaggaag cctgccttct
tgtccggaga gcagaagaag gccatcgtcg acctgctctt 3720caagaccaac
aggaaggtga ctgtcaagca gctgaaggag gactacttca agaagatcga
3780gtgcttcgac tccgtcgaga tctctggtgt cgaggacagg ttcaacgcct
cccttgggac 3840ttaccacgat ctgctcaaga ttattaaaga caaggacttc
ctggacaacg aggagaacga 3900ggacatcctt gaggacatcg tgctcaccct
gaccttgttc gaagacaggg aaatgatcga 3960agagaggctc aagacctacg
cccacctctt cgacgacaag gtgatgaaac agctgaagag 4020acgcagatat
accggctggg gaaggctctc ccgcaaattg atcaacggga tcagggacaa
4080gcagtcaggg aagactatac tcgacttcct gaagtccgac ggattcgcca
acaggaactt 4140catgcagctc attcacgacg actccttgac cttcaaggag
gacatccaga aggctcaggt 4200gtctggacag ggtgactcct tgcatgagca
cattgctaac ttggccggct ctcccgctat 4260taagaagggc attttgcaga
ccgtgaaggt cgttgacgag ctcgtgaagg tgatgggacg 4320ccacaagcca
gagaacatcg ttattgagat ggctcgcgag aaccaaacta cccagaaagg
4380gcagaagaat tcccgcgaga ggatgaagcg cattgaggag ggcataaaag
agcttggctc 4440tcagatcctc aaggagcacc ccgtcgagaa cactcagctg
cagaacgaga agctgtacct 4500gtactacctc caaaacggaa gggacatgta
cgtggaccag gagctggaca tcaacaggtt 4560gtccgactac gacgtcgacc
acatcgtgcc tcagtccttc ctgaaggatg actccatcga 4620caataaagtg
ctgacacgct ccgataaaaa tagaggcaag tccgacaacg tcccctccga
4680ggaggtcgtg aagaagatga aaaactactg gagacagctc ttgaacgcca
agctcatcac 4740ccagcgtaag ttcgacaacc tgactaaggc tgagagagga
ggattgtccg agctcgataa 4800ggccggattc atcaagagac agctcgtcga
aacccgccaa attaccaagc acgtggccca 4860aattctggat tcccgcatga
acaccaagta cgatgaaaat gacaagctga tccgcgaggt 4920caaggtgatc
accttgaagt ccaagctggt ctccgacttc cgcaaggact tccagttcta
4980caaggtgagg gagatcaaca actaccacca cgcacacgac gcctacctca
acgctgtcgt 5040tggaaccgcc ctcatcaaaa aatatcctaa gctggagtct
gagttcgtct acggcgacta 5100caaggtgtac gacgtgagga agatgatcgc
taagtctgag caggagatcg gcaaggccac 5160cgccaagtac ttcttctact
ccaacatcat gaacttcttc aagaccgaga tcactctcgc 5220caacggtgag
atcaggaagc gcccactgat cgagaccaac ggtgagactg gagagatcgt
5280gtgggacaaa gggagggatt tcgctactgt gaggaaggtg ctctccatgc
ctcaggtgaa 5340catcgtcaag aagaccgaag ttcagaccgg aggattctcc
aaggagtcca tcctccccaa 5400gagaaactcc gacaagctga tcgctagaaa
gaaagactgg gaccctaaga agtacggagg 5460cttcgattct cctaccgtgg
cctactctgt gctggtcgtg gccaaggtgg agaagggcaa 5520gtccaagaag
ctgaaatccg tcaaggagct cctcgggatt accatcatgg agaggagttc
5580cttcgagaag aaccctatcg acttcctgga ggccaaggga tataaagagg
tgaagaagga 5640cctcatcatc aagctgccca agtactccct cttcgagttg
gagaacggaa ggaagaggat 5700gctggcttct gccggagagt tgcagaaggg
aaatgagctc gcccttccct ccaagtacgt 5760gaacttcctg tacctcgcct
ctcactatga aaagttgaag ggctctcctg aggacaacga 5820gcagaagcag
ctcttcgtgg agcagcacaa gcactacctg gacgaaatta tcgagcagat
5880ctctgagttc tccaagcgcg tgatattggc cgacgccaac ctcgacaagg
tgctgtccgc 5940ctacaacaag cacagggata agcccattcg cgagcaggct
gaaaacatta tccacctgtt 6000taccctcaca aacttgggag cccctgctgc
cttcaagtac ttcgacacca ccattgacag 6060gaagagatac acctccacca
aggaggtgct cgacgcaaca ctcatccacc aatccatcac 6120cggcctctat
gaaacaagga ttgacttgtc ccagctggga ggcgactcta gagccgatcc
6180caagaagaag agaaaggtgt aggttaacct agacttgtcc atcttctgga
ttggccaact 6240taattaatgt atgaaataaa aggatgcaca catagtgaca
tgctaatcac tataatgtgg 6300gcatcaaagt tgtgtgttat gtgtaattac
tagttatctg aataaaagag aaagagatca 6360tccatatttc ttatcctaaa
tgaatgtcac gtgtctttat aattctttga tgaaccagat 6420gcatttcatt
aaccaaatcc atatacatat aaatattaat catatataat taatatcaat
6480tgggttagca aaacaaatct agtctaggtg tgttttgcga attcgatatc
aagcttatcg 6540ataccgtcga gggggggccc ggtaccggcg cgccgttcta
tagtgtcacc taaatcgtat 6600gtgtatgata cataaggtta tgtattaatt
gtagccgcgt tctaacgaca atatgtccat 6660atggtgcact ctcagtacaa
tctgctctga tgccgcatag ttaagccagc cccgacaccc 6720gccaacaccc
gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca
6780agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat
caccgaaacg 6840cgcgagacga aagggcctcg tgatacgcct atttttatag
gttaatgtca tgaccaaaat 6900cccttaacgt gagttttcgt tccactgagc
gtcagacccc gtagaaaaga tcaaaggatc 6960ttcttgagat cctttttttc
tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct 7020accagcggtg
gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg
7080cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt
taggccacca 7140cttcaagaac tctgtagcac cgcctacata cctcgctctg
ctaatcctgt taccagtggc 7200tgctgccagt ggcgataagt cgtgtcttac
cgggttggac tcaagacgat agttaccgga 7260taaggcgcag cggtcgggct
gaacgggggg ttcgtgcaca cagcccagct tggagcgaac 7320gacctacacc
gaactgagat acctacagcg tgagcattga gaaagcgcca cgcttcccga
7380agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag
agcgcacgag 7440ggagcttcca gggggaaacg cctggtatct ttatagtcct
gtcgggtttc gccacctctg 7500acttgagcgt cgatttttgt gatgctcgtc
aggggggcgg agcctatgga aaaacgccag 7560caacgcggcc tttttacggt
tcctggcctt ttgctggcct tttgctcaca tgttctttcc 7620tgcgttatcc
cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc
7680tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg
aagagcgccc 7740aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat
taatgcaggt tgatcagatc 7800tcgatcccgc gaaattaata cgactcacta
tagggagacc acaacggttt ccctctagaa 7860ataattttgt ttaactttaa
gaaggagata tacccatgga aaagcctgaa ctcaccgcga 7920cgtctgtcga
gaagtttctg atcgaaaagt tcgacagcgt ctccgacctg atgcagctct
7980cggagggcga agaatctcgt gctttcagct tcgatgtagg agggcgtgga
tatgtcctgc 8040gggtaaatag ctgcgccgat ggtttctaca aagatcgtta
tgtttatcgg cactttgcat 8100cggccgcgct cccgattccg gaagtgcttg
acattgggga attcagcgag agcctgacct 8160attgcatctc ccgccgtgca
cagggtgtca cgttgcaaga cctgcctgaa accgaactgc 8220ccgctgttct
gcagccggtc gcggaggcta tggatgcgat cgctgcggcc gatcttagcc
8280agacgagcgg gttcggccca ttcggaccgc aaggaatcgg tcaatacact
acatggcgtg 8340atttcatatg cgcgattgct gatccccatg tgtatcactg
gcaaactgtg atggacgaca 8400ccgtcagtgc gtccgtcgcg caggctctcg
atgagctgat gctttgggcc gaggactgcc 8460ccgaagtccg gcacctcgtg
cacgcggatt tcggctccaa caatgtcctg acggacaatg 8520gccgcataac
agcggtcatt gactggagcg aggcgatgtt cggggattcc caatacgagg
8580tcgccaacat cttcttctgg aggccgtggt tggcttgtat ggagcagcag
acgcgctact 8640tcgagcggag gcatccggag cttgcaggat cgccgcggct
ccgggcgtat atgctccgca 8700ttggtcttga ccaactctat cagagcttgg
ttgacggcaa tttcgatgat gcagcttggg 8760cgcagggtcg atgcgacgca
atcgtccgat ccggagccgg gactgtcggg cgtacacaaa 8820tcgcccgcag
aagcgcggcc gtctggaccg atggctgtgt agaagtactc gccgatagtg
8880gaaaccgacg ccccagcact cgtccgaggg caaaggaata gtgaggtaca
gcttggatcg 8940atccggctgc taacaaagcc cgaaaggaag ctgagttggc
tgctgccacc gctgagcaat 9000aactagcata accccttggg gcctctaaac
gggtcttgag gggttttttg ctgaaaggag 9060gaactatatc cggatgatcg
ggcgcgccgg tac 90931244107DNAS. pyogenes 124atggataaga aatactcaat
aggcttagat atcggcacaa atagcgtcgg atgggcggtg 60atcactgatg attataaggt
tccgtctaaa aagctcaagg gtctgggaaa tacagaccgc 120cacggtatca
aaaaaaatct tataggggct cttttatttg acagtggaga gacagcggaa
180gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa
tcgtatttgt 240tatctacagg agattttttc aaatgagatg gcgaaagtag
atgatagttt ctttcatcga 300cttgaagagt cttttttggt ggaagaagac
aagaagcatg aacgtcatcc tatttttgga 360aatatagtag atgaagttgc
ttatcatgag aaatatccaa ctatctatca tctgcgaaaa 420aaattggcag
attctactga taaagtggat ttgcgcttaa tctatttggc cttagcgcat
480atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga
taatagtgat 540gtggacaaac tatttatcca gttggtacaa acctacaatc
aattatttga agaaaaccct 600attaacgcaa gtagagtaga tgctaaagcg
attctttctg cacgattgag taaatcaaga 660cgattagaaa atctcattgc
tcagctcccc ggtgagaaga aaaatggatt gtttgggaat 720ctcattgctt
tgtcattggg attgacccct aattttaaat caaattttga tttggcagaa
780gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa
tttattggcg 840caaattggag atcaatatgc tgatttgttt ttggcagcta
agaatttatc agatgctact 900ttactttcag atatcctaag agtaaatagt
gaaataacta aggctcccct atcagcttca 960atgattaagc gctacgatga
acatcatcaa gacttgactc ttttaaaagc tttagttcga 1020caacaacttc
cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca
1080ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa
accaatttta 1140gaaaaaatgg atggtactga ggaattattg gcgaaactaa
atcgtgaaga tttgctgcgc 1200aagcaacgga cctttgacaa cggctctatt
ccctatcaaa ttcacttggg tgagctgcat 1260gctattttga gaagacaaga
agacttttat ccatttttaa aagacaatcg tgagaagatt 1320gaaaaaatct
tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt
1380cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa
ttttgaagaa 1440gttgtcgata aaggtgcttc agctcaatca tttattgaac
gcatgacaaa ctttgataaa 1500aatcttccaa atgaaaaagt actaccaaaa
catagtttgc tttatgagta ttttacggtt 1560tataacgaat tgacaaaagt
caaatatgtt actgagggaa tgcgaaaacc agcatttctt 1620tcaggtgaac
agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc
1680gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag
tgttgaaatt 1740tcaggagttg aagatagatt taatgcttca ttaggtacct
accatgattt gctaaaaatt 1800attaaagata aagatttttt ggataatgaa
gaaaacgaag atatcttaga ggatattgtt 1860ttaacattga ccttatttga
agatagggag atgattgagg aaagacttaa aacatatgct 1920cacctctttg
atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga
1980cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa
aacaatatta 2040gattttttga aatcagatgg ttttgccaat cgcaatttta
tgcagctgat ccatgatgat 2100agtttgacat ttaaagaaga cattcaaaaa
gcacaagtgt ctggacaagg cgatagttta 2160catgaacata ttgcaaattt
agctggtagc cctgctatta aaaaaggtat tttacagact 2220gtaaaagttg
ttgatgaatt ggtcaaagta atggggcggc ataagccaga aaatatcgtt
2280attgaaatgg cacgtgaaaa tcagacaact caaaagggcc agaaaaattc
gcgtgagcgt 2340atgaaacgta ttgaagaagg aataaaagaa ctaggaagtg
atattctaaa ggagtatcct 2400gttgaaaaca ctcaattaca aaatgaaaag
ctctatctct attatctcca aaatggaaga 2460gacatgtatg tggaccaaga
attagatatt aatcgtttaa gtgattatga tgtcgatcac 2520attgttccac
aaagtttcct taaagacgat tcaatagaca ataaggtctt aacgcgttct
2580gataaaaatc gtggtaaatc ggataacgtt ccaagtgaag aagtagtcaa
aaagatgaaa 2640aactattgga gacaacttct aaacgccaag ttaatcactc
aacgtaagtt tgataattta 2700acaaaagctg aacgtggagg tttgagtgaa
cttgataaag ttggttttat caaacgccaa 2760ttggttgaaa ctcgccaaat
cactaagcat gtggcacaaa ttttggatag tcgcatgaat 2820actaaatacg
atgaaaatga taaacttatt cgagaggtta gagtgattac cttaaaatct
2880aaattagttt ctgacttccg aaaagatttc caattctata aagtacgtga
gattaacaat 2940taccatcatg cccatgatgc gtatcttaat gccgtcgttg
gaactgcttt gattaagaaa 3000tatccaaaac ttgaatcgga gtttgtctat
ggtgattata aagtttatga tgttcgtaaa 3060atgattgcta agtctgagca
ggaaataggc aaagcaaccg caaaatattt cttttactct 3120aatatcatga
acttcttcaa aacagaaatt acacttgcaa atggagagat tcgcaaacgc
3180cctctaatcg aaactaatgg ggaaactgga gaaattgtct gggataaagg
gcgagatttt 3240gccacagtgc gcaaagtatt gtccatgccc caagtcaata
ttgtcaagaa aacagaagta 3300cagacaggcg gattctccaa ggagtcaatt
ttaccaaaaa gaaattcgga caagcttatt 3360gctcgtaaaa aagactggga
tccaaaaaaa tatggtggtt ttgatagtcc aacggtagct 3420tattcagtcc
tagtggttgc taaggtggaa aaagggaaat cgaagaagtt aaaatccgtt
3480aaagagttac tagggatcac aataatggaa agaagctctt ttgaaaaaga
tccgattgac 3540tttttagaag ctaaaggata taaggaagtt agaaaagact
taatcattaa actacctaaa 3600tatagtcttt ttgagttaga aaacggtcgt
aaacggatgc tggctagtgc cggagaattg 3660caaaaaggaa atgagctagc
tctgccaagc aaatatgtga attttttata tttagctagt 3720cattatgaaa
agttgaaggg tagtccagaa gataacgaac aaaaacaatt gtttgtggag
3780cagcataagc attatttaga tgagattatt gagcaaatca gtgaattttc
taagcgtgtt 3840attttagcag atgccaattt agataaagtt cttagtgcat
ataacaaaca tagagacaaa 3900ccaatacgtg aacaagcaga aaatattatt
catttattta cgttgacgaa tcttggagct 3960cccgctgctt ttaaatattt
tgatacaaca attgatcgta aacgatatac gtctacaaaa 4020gaagttttag
atgccactct tatccatcaa tccatcactg gtctttatga aacacgcatt
4080gatttgagtc agctaggagg tgactga 410712520DNAGlycine max
125ggaactgaca cacgacatga 2012620DNAGlycine max 126gacatgatgg
aacgtgacta 2012720DNAGlycine max 127gtcccttgta cttgtacgta
2012820DNAGlycine max 128gtattctaga aaagaggaat 2012970DNAGlycine
max 129atcaaaattc ggaactgaca cacgacatga tggaacgtga ctaaggtggg
tttttgactt 60tgcatgtcga 7013070DNAGlycine max 130tcgacatgca
aagtcaaaaa cccaccttag tcacgttcca tcatgtcgtg tgtcagttcc 60gaattttgat
7013170DNAGlycine max 131ggcagactcc aattcctctt ttctagaata
ccctccgtac gtacaagtac aagggacttg 60tgagttgtaa 7013270DNAGlycine max
132ttacaactca caagtccctt gtacttgtac gtacggaggg tattctagaa
aagaggaatt 60ggagtctgcc 7013371DNAGlycine max 133ctacactctt
tccctacacg acgctcttcc gatctggaat ttacagcaca agtagatcac 60ttgtacttat
c 7113459DNAGlycine max 134caagcagaag acggcatacg agctcttccg
atctaaatca ctctcacttc gacatgcaa 5913571DNAGlycine max 135ctacactctt
tccctacacg acgctcttcc gatctttcct ttacagcaca agtagatcac 60ttgtacttat
c 7113668DNAGlycine max 136ctacactctt tccctacacg acgctcttcc
gatctagctg taaatacagc cttacaactc 60acaagtcc 6813763DNAArtificial
sequencePrimer, DD43-A 137caagcagaag acggcatacg agctcttccg
atctttaatt taggactaaa agaagaggca 60gac 6313868DNAArtificial
sequencePrimer, DD43-S4 138ctacactctt tccctacacg acgctcttcc
gatctctagg taaatacagc cttacaactc 60acaagtcc 6813968DNAArtificial
sequencePrimer, DD43-S5 139ctacactctt tccctacacg acgctcttcc
gatctgatcg taaatacagc cttacaactc 60acaagtcc 6814043DNAArtificial
sequencePrimer, JKY557 140aatgatacgg cgaccaccga gatctacact
ctttccctac acg 4314118DNAArtificial sequenceprimer, JKY558
141caagcagaag acggcata 18142117DNAArtificial sequenceDD20CR1 PCR
amplicon 142ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacgaca 60tgatggaacg tgactaaggt gggtttttga ctttgcatgt cgaagtgaga
gtgattt 117143117DNAArtificial sequenceDD20CR2 PCR amplicon
143ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacgaca 60tgatggaacg tgactaaggt gggtttttga ctttgcatgt cgaagtgaga
gtgattt 117144108DNAArtificial sequenceDD43CR1 PCR amplicon
144agctgtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaaaaga ggaattggag tctgcctctt cttttagtcc taaattaa
108145108DNAArtificial sequenceDD43CR2 PCR amplicon 145ctaggtaaat
acagccttac aactcacaag tcccttgtac ttgtacgtac ggagggtatt 60ctagaaaaga
ggaattggag tctgcctctt cttttagtcc taaattaa 108146108DNAartificial
sequenceamplicon 146ctaggtaaat acagccttac aactcacaag tcccttgtac
ttgtacgtac ggagggtatt 60ctagaaaaga ggaattggag tctgcctctt cttttagtcc
taaattaa 108147101DNAArtificial sequenceDD20CR1 mutant target site
147ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacgatg 60atggaacgtg actaaggtgg gtttttgact ttgcatgtcg a
101148101DNAArtificial sequenceDD20CR1 mutant target site
148ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacgatg 60gaacgtgact aaggtgggtt tttgactttg catgtcgaag t
101149101DNAArtificial sequenceDD20CR1 mutant target site
149ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacgact 60gatggaacgt gactaaggtg ggtttttgac tttgcatgtc g
101150101DNAArtificial sequenceDD20CR1 mutant target site
150ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacatgg 60aacgtgacta aggtgggttt ttgactttgc atgtcgaagt g
101151101DNAArtificial sequenceDD20CR1 mutant target site
151ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacatgatg 60gaacgtgact aaggtgggtt tttgactttg catgtcgaag t
101152101DNAArtificial sequenceDD20CR1 mutant target site
152ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacagacat 60gatggaacgt gactaaggtg ggtttttgac tttgcatgtc g
101153101DNAArtificial sequenceDD20CR1 mutant target site
153ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacgacatg 60atggaacgtg actaaggtgg gtttttgact ttgcatgtcg a
101154101DNAArtificial sequenceDD20CR1 mutant target site i
154ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacaagaaa 60tgatggaacg tgactaaggt gggtttttga ctttgcatgt c
101155101DNAArtificial sequenceDD20CR1 mutant target site
155ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacgatt 60gaacgtgact aaggtgggtt tttgactttg catgtcgaag t
101156101DNAArtificial sequenceDD20CR1 mutant target site
156ggaatttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacattg 60aacgtgacta aggtgggttt ttgactttgc atgtcgaagt g
101157101DNAArtificial sequenceDD20CR2 mutant target site
157ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacgaca 60tgatggaacg tctaaggtgg gtttttgact ttgcatgtcg a
101158101DNAArtificial sequenceDD20CR2 mutant target site
158ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacgaca 60tgatggaacc taaggtgggt ttttgacttt gcatgtcgaa g
101159101DNAArtificial sequenceDD20CR2 mutant target site
159ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacgaca 60tgatggaacg tgactaggtg ggtttttgac tttgcatgtc g
101160101DNAArtificial sequenceDD20CR2 mutant target site
160ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacgaca 60tgatggaact aaggtgggtt tttgactttg catgtcgaag t
101161101DNAArtificial sequenceDD20CR2 mutant target site
161ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacgaca 60tgatggaacg
aaggtgggtt tttgactttg catgtcgaag t 101162101DNAArtificial
sequenceDD20CR2 mutant target site 162ttcctttaca gcacaagtag
atcacttgta cttatcaaaa ttcggaactg acacacgaca 60tgatggaagg tgggtttttg
actttgcatg tcgaagtgag a 101163101DNAArtificial sequenceDD20CR2
mutant target site i 163ttcctttaca gcacaagtag atcacttgta cttatcaaaa
ttcggaactg acacacgaca 60tgatggacgt gactaaggtg ggtttttgac tttgcatgtc
g 101164101DNAArtificial sequenceDD20CR2 mutant target site
164ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacgaca 60tgatggaact ttactaaggt gggtttttga ctttgcatgt c
101165101DNAArtificial sequenceDD20CR2 mutant target site
165ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacacgaca 60tgatggaacg tgacaaggtg ggtttttgac tttgcatgtc g
101166101DNAArtificial sequenceDD20CR2 mutant target site
166ttcctttaca gcacaagtag atcacttgta cttatcaaaa ttcggaactg
acacactaca 60ttatttaact ttactaaggt gggtttttga ctttgcatgt c
101167108DNAArtificial sequenceDD43CR1 mutant target site
167agctgtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaaaaga ggaattggag tctgcctctt cttttagtcc taaattaa
108168101DNAArtificial sequenceDD43CR1 mutant target site
168agctgtaaat acagccttac aactcacaag tcccttgtac ggagggtatt
ctagaaaaga 60ggaattggag tctgcctctt cttttagtcc taaattaaag a
101169101DNAArtificial sequenceDD43CR1 mutant target site
169agctgtaaat acagccttac aactcacaag tcccttgtac ttgtacggag
ggtattctag 60aaaagaggaa ttggagtctg cctcttcttt tagtcctaaa t
101170101DNAArtificial sequenceDD43CR1 mutant target site
170agctgtaaat acagccttac aactcacaag tcccttacgg agggtattct
agaaaagagg 60aattggagtc tgcctcttct tttagtccta aattaaagat c
101171101DNAArtificial sequenceDD43CR1 mutant target site
171agctgtaaat acagccttac aactcacaag tcccttgtac ttgtaccgta
cggagggtat 60tctagaaaag aggaattgga gtctgcctct tcttttagtc c
101172101DNAArtificial sequenceDD43CR1 mutant target site
172agctgtaaat acagccttac aactcacaag tcccttgtac tgtacggagg
gtattctaga 60aaagaggaat tggagtctgc ctcttctttt agtcctaaat t
101173101DNAArtificial sequenceDD43CR1 mutant target site
173agctgtaaat acagccttac aactcacaag tcccttgtag tacggagggt
attctagaaa 60agaggaattg gagtctgcct cttcttttag tcctaaatta a
101174101DNAArtificial sequenceDD43CR1 mutant target site
174agctgtaaat acagccttac aactcacaag tcccttgtac ttgtacgtag
ggtattctag 60aaaagaggaa ttggagtctg cctcttcttt tagtcctaaa t
101175100DNAArtificial sequenceDD43CR1 mutant target site
175agctgtaaat acagccttac aactcacaag tcctacactc tttccctaca
cgacgctctt 60cttttagtcc taaattaaag atcggaagat ctcgtatgcc
100176101DNAArtificial sequenceDD43CR1 mutant target site
176agctgtaaat acagccttac aactcacaag tcccttgtac ttgtacctta
cggagggtat 60tctagaaaag aggaattgga gtctgcctct tcttttagtc c
101177101DNAArtificial sequenceDD43CR2 mutant target site
177ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaaaatt ggagtctgcc tcttctttta gtcctaaatt a
101178101DNAArtificial sequenceDD43CR2 mutant target site
178ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaaaaga attggagtct gcctcttctt ttagtcctaa a
101179101DNAArtificial sequenceDD43CR2 mutant target site
179ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaattgg agtctgcctc ttcttttagt cctaaattaa a
101180101DNAArtificial sequenceDD43CR2 mutant target site
180ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaaaaga aattggagtc tgcctcttct tttagtccta a
101181101DNAArtificial sequenceDD43CR2 mutant target site
181ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaaaaat tggagtctgc ctcttctttt agtcctaaat t
101182101DNAArtificial sequenceDD43CR2 mutant target site
182ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaaaaga ggattggagt ctgcctcttc ttttagtcct a
101183101DNAArtificial sequenceDD43CR2 mutant target site
183ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaaattg gagtctgcct cttcttttag tcctaaatta a
101184101DNAArtificial sequenceDD43CR2 mutant target site
184ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctattggagt ctgcctcttc ttttagtcct aaattaaaga t
101185101DNAArtificial sequenceDD43CR2 mutant target site
185ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagtctgcc tcttctttta gtcctaaatt aaagatcgga a
101186101DNAArtificial sequenceDD43CR2 mutant target site
186ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaaaagt ctgcctcttc ttttagtcct aaattaaaga t
101187101DNAArtificial sequenceDD43CR2 mutant target site
187ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaaaaga gaattggagt ctgcctcttc ttttagtcct a
101188101DNAArtificial sequenceDD43CR2 mutant target site
188ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaaaaga ggagtctgcc tcttctttta gtcctaaatt a
101189101DNAArtificial sequenceDD43CR2 mutant target site
189ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctaattggag tctgcctctt cttttagtcc taaattaaag a
101190101DNAArtificial sequenceDD43CR2 mutant target site
190ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaaaaga ggaaattgga gtctgcctct tcttttagtc c
101191101DNAArtificial sequenceDD43CR2 mutant target site
191ctaggtaaat acagccttac aactcacaag tcccttgtac ttgtacgtac
ggagggtatt 60ctagaaagag gaattggagt ctgcctcttc ttttagtcct a
1011921377PRTArtificial sequencemaize optimized moCAS9 endonuclease
192Met Ala Pro Lys Lys Lys Arg Lys Val Met Asp Lys Lys Tyr Ser Ile
1 5 10 15 Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile
Thr Asp 20 25 30 Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu
Gly Asn Thr Asp 35 40 45 Arg His Ser Ile Lys Lys Asn Leu Ile Gly
Ala Leu Leu Phe Asp Ser 50 55 60 Gly Glu Thr Ala Glu Ala Thr Arg
Leu Lys Arg Thr Ala Arg Arg Arg 65 70 75 80 Tyr Thr Arg Arg Lys Asn
Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser 85 90 95 Asn Glu Met Ala
Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu 100 105 110 Ser Phe
Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe 115 120 125
Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile 130
135 140 Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp
Leu 145 150 155 160 Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys
Phe Arg Gly His 165 170 175 Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp
Asn Ser Asp Val Asp Lys 180 185 190 Leu Phe Ile Gln Leu Val Gln Thr
Tyr Asn Gln Leu Phe Glu Glu Asn 195 200 205 Pro Ile Asn Ala Ser Gly
Val Asp Ala Lys Ala Ile Leu Ser Ala Arg 210 215 220 Leu Ser Lys Ser
Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly 225 230 235 240 Glu
Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly 245 250
255 Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys
260 265 270 Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn
Leu Leu 275 280 285 Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu
Ala Ala Lys Asn 290 295 300 Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile
Leu Arg Val Asn Thr Glu 305 310 315 320 Ile Thr Lys Ala Pro Leu Ser
Ala Ser Met Ile Lys Arg Tyr Asp Glu 325 330 335 His His Gln Asp Leu
Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu 340 345 350 Pro Glu Lys
Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr 355 360 365 Ala
Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe 370 375
380 Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val
385 390 395 400 Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr
Phe Asp Asn 405 410 415 Gly Ser Ile Pro His Gln Ile His Leu Gly Glu
Leu His Ala Ile Leu 420 425 430 Arg Arg Gln Glu Asp Phe Tyr Pro Phe
Leu Lys Asp Asn Arg Glu Lys 435 440 445 Ile Glu Lys Ile Leu Thr Phe
Arg Ile Pro Tyr Tyr Val Gly Pro Leu 450 455 460 Ala Arg Gly Asn Ser
Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu 465 470 475 480 Thr Ile
Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser 485 490 495
Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro 500
505 510 Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe
Thr 515 520 525 Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu
Gly Met Arg 530 535 540 Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys
Ala Ile Val Asp Leu 545 550 555 560 Leu Phe Lys Thr Asn Arg Lys Val
Thr Val Lys Gln Leu Lys Glu Asp 565 570 575 Tyr Phe Lys Lys Ile Glu
Cys Phe Asp Ser Val Glu Ile Ser Gly Val 580 585 590 Glu Asp Arg Phe
Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys 595 600 605 Ile Ile
Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile 610 615 620
Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met 625
630 635 640 Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp
Lys Val 645 650 655 Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp
Gly Arg Leu Ser 660 665 670 Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys
Gln Ser Gly Lys Thr Ile 675 680 685 Leu Asp Phe Leu Lys Ser Asp Gly
Phe Ala Asn Arg Asn Phe Met Gln 690 695 700 Leu Ile His Asp Asp Ser
Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala 705 710 715 720 Gln Val Ser
Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu 725 730 735 Ala
Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val 740 745
750 Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile
755 760 765 Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly
Gln Lys 770 775 780 Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly
Ile Lys Glu Leu 785 790 795 800 Gly Ser Gln Ile Leu Lys Glu His Pro
Val Glu Asn Thr Gln Leu Gln 805 810 815 Asn Glu Lys Leu Tyr Leu Tyr
Tyr Leu Gln Asn Gly Arg Asp Met Tyr 820 825 830 Val Asp Gln Glu Leu
Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 835 840 845 His Ile Val
Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys 850 855 860 Val
Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro 865 870
875 880 Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu
Leu 885 890 895 Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu
Thr Lys Ala 900 905 910 Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala
Gly Phe Ile Lys Arg 915 920 925 Gln Leu Val Glu Thr Arg Gln Ile Thr
Lys His Val Ala Gln Ile Leu 930 935 940 Asp Ser Arg Met Asn Thr Lys
Tyr Asp Glu Asn Asp Lys Leu Ile Arg 945 950 955 960 Glu Val Lys Val
Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 965 970 975 Lys Asp
Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His 980 985 990
Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu Ile Lys 995
1000 1005 Lys Tyr Pro Lys Leu Glu Ser Glu Phe Val Tyr Gly Asp Tyr
Lys 1010 1015 1020 Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu
Gln Glu Ile 1025 1030 1035 Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr
Ser Asn Ile Met Asn 1040 1045 1050 Phe Phe Lys Thr Glu Ile Thr Leu
Ala Asn Gly Glu Ile Arg Lys 1055 1060 1065 Arg Pro Leu Ile Glu Thr
Asn Gly Glu Thr Gly Glu Ile Val Trp 1070 1075 1080 Asp Lys Gly Arg
Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met 1085 1090 1095 Pro Gln
Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly 1100 1105 1110
Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu 1115
1120 1125 Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly
Phe 1130 1135 1140 Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val
Ala Lys Val 1145 1150 1155 Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser
Val Lys Glu Leu Leu 1160 1165 1170 Gly Ile Thr Ile Met Glu Arg Ser
Ser Phe Glu Lys Asn Pro Ile 1175 1180 1185 Asp Phe Leu Glu Ala Lys
Gly Tyr Lys Glu Val Lys Lys Asp Leu 1190 1195 1200 Ile Ile Lys Leu
Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly 1205 1210 1215 Arg Lys
Arg Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn 1220 1225 1230
Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala 1235
1240 1245 Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu
Gln 1250 1255 1260 Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu
Asp Glu Ile 1265 1270 1275 Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg
Val Ile Leu Ala Asp 1280 1285 1290 Ala Asn Leu Asp Lys Val Leu Ser
Ala Tyr Asn Lys His Arg Asp 1295 1300 1305 Lys Pro Ile Arg Glu Gln
Ala Glu Asn Ile Ile His Leu Phe Thr 1310 1315 1320 Leu Thr Asn Leu
Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr 1325 1330 1335 Thr Ile
Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp 1340 1345 1350
Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg 1355
1360 1365 Ile Asp Leu Ser Gln Leu Gly Gly Asp 1370 1375
1936677DNAArtificial sequencemaize optimized moCAS9 endonuclease
193ctgcagtgca gcgtgacccg gtcgtgcccc tctctagaga taatgagcat
tgcatgtcta 60agttataaaa aattaccaca tatttttttt gtcacacttg tttgaagtgc
agtttatcta 120tctttataca tatatttaaa ctttactcta cgaataatat
aatctatagt actacaataa 180tatcagtgtt ttagagaatc atataaatga
acagttagac atggtctaaa ggacaattga 240gtattttgac aacaggactc
tacagtttta tctttttagt gtgcatgtgt tctccttttt 300ttttgcaaat
agcttcacct atataatact
tcatccattt tattagtaca tccatttagg 360gtttagggtt aatggttttt
atagactaat ttttttagta catctatttt attctatttt 420agcctctaaa
ttaagaaaac taaaactcta ttttagtttt tttatttaat aatttagata
480taaaatagaa taaaataaag tgactaaaaa ttaaacaaat accctttaag
aaattaaaaa 540aactaaggaa acatttttct tgtttcgagt agataatgcc
agcctgttaa acgccgtcga 600cgagtctaac ggacaccaac cagcgaacca
gcagcgtcgc gtcgggccaa gcgaagcaga 660cggcacggca tctctgtcgc
tgcctctgga cccctctcga gagttccgct ccaccgttgg 720acttgctccg
ctgtcggcat ccagaaattg cgtggcggag cggcagacgt gagccggcac
780ggcaggcggc ctcctcctcc tctcacggca cggcagctac gggggattcc
tttcccaccg 840ctccttcgct ttcccttcct cgcccgccgt aataaataga
caccccctcc acaccctctt 900tccccaacct cgtgttgttc ggagcgcaca
cacacacaac cagatctccc ccaaatccac 960ccgtcggcac ctccgcttca
aggtacgccg ctcgtcctcc cccccccccc tctctacctt 1020ctctagatcg
gcgttccggt ccatgcatgg ttagggcccg gtagttctac ttctgttcat
1080gtttgtgtta gatccgtgtt tgtgttagat ccgtgctgct agcgttcgta
cacggatgcg 1140acctgtacgt cagacacgtt ctgattgcta acttgccagt
gtttctcttt ggggaatcct 1200gggatggctc tagccgttcc gcagacggga
tcgatttcat gatttttttt gtttcgttgc 1260atagggtttg gtttgccctt
ttcctttatt tcaatatatg ccgtgcactt gtttgtcggg 1320tcatcttttc
atgctttttt ttgtcttggt tgtgatgatg tggtctggtt gggcggtcgt
1380tctagatcgg agtagaattc tgtttcaaac tacctggtgg atttattaat
tttggatctg 1440tatgtgtgtg ccatacatat tcatagttac gaattgaaga
tgatggatgg aaatatcgat 1500ctaggatagg tatacatgtt gatgcgggtt
ttactgatgc atatacagag atgctttttg 1560ttcgcttggt tgtgatgatg
tggtgtggtt gggcggtcgt tcattcgttc tagatcggag 1620tagaatactg
tttcaaacta cctggtgtat ttattaattt tggaactgta tgtgtgtgtc
1680atacatcttc atagttacga gtttaagatg gatggaaata tcgatctagg
ataggtatac 1740atgttgatgt gggttttact gatgcatata catgatggca
tatgcagcat ctattcatat 1800gctctaacct tgagtaccta tctattataa
taaacaagta tgttttataa ttattttgat 1860cttgatatac ttggatgatg
gcatatgcag cagctatatg tggatttttt tagccctgcc 1920ttcatacgct
atttatttgc ttggtactgt ttcttttgtc gatgctcacc ctgttgtttg
1980gtgttacttc tgcaggtcga ctctagagga tccccatggc cccgaagaag
aagaggaagg 2040tgcacatgga taagaagtac agcatcggcc tcgacatcgg
gaccaacagc gtcggctggg 2100ccgtcatcac cgacgaatat aaggtgccca
gcaagaagtt caaggtgctc gggaatacag 2160accgccacag catcaagaag
aacctgatcg gcgccctcct gttcgactcg ggcgagaccg 2220ctgaggccac
cagactaaag aggaccgctc gccgccgcta cacccgccgc aagaaccgca
2280tatgctacct ccaggagatc ttcagcaacg agatggccaa ggtggacgac
agcttcttcc 2340accgccttga ggagtcgttc ctcgtggagg aggacaagaa
gcatgagagg cacccgatct 2400tcgggaacat cgtggacgag gtaagtttct
gcttctacct ttgatatata tataataatt 2460atcattaatt agtagtaata
taatatttca aatatttttt tcaaaataaa agaatgtagt 2520atatagcaat
tgcttttctg tagtttataa gtgtgtatat tttaatttat aacttttcta
2580atatatgacc aaaacatggt gatgtgcagg tggcgtacca cgagaagtac
ccgacgatct 2640accacctccg caagaagctg gtcgactcca cagacaaggc
cgacctcaga ctgatctacc 2700tggccctcgc gcacatgatc aagttccgcg
ggcacttcct catcgagggc gacctgaacc 2760cggacaactc cgacgtcgac
aagctcttca tccagctggt ccagacctac aatcaactgt 2820tcgaggagaa
cccgatcaac gcgtccggcg tggacgcgaa ggccatcctc agcgcgaggc
2880tcagcaaatc aagacggctg gagaacctga tcgcccagct cccaggcgag
aagaaaaacg 2940gcttgttcgg caacctgatc gcgctctcgc tcggcctcac
gcccaacttc aaatcaaact 3000tcgacctggc cgaggacgcg aaactgcagc
tgtccaagga cacttacgac gacgacctcg 3060acaacctgct ggcgcaaatc
ggtgaccagt acgcagacct cttcctggcc gccaagaacc 3120tctcggacgc
catcctgctg tccgatatcc tgagagtgaa tacggagatc accaaggcgc
3180cgctcagcgc ctccatgatt aaaaggtacg acgagcacca ccaggacctg
acgctgctca 3240aggccctggt gcgccagcag ctccccgaga agtacaagga
gatcttcttc gaccaatcaa 3300aaaacggcta cgccggctac atcgacgggg
gcgcctccca ggaggagttc tacaagttca 3360tcaaaccaat tctcgagaag
atggacggca cggaggagct tctcgtgaag ctcaaccggg 3420aggacctcct
gaggaagcag aggacgttcg acaacggctc gataccgcat cagatccacc
3480tgggcgagct ccacgccatc ctgcgccggc aggaggattt ctatccgttc
ctcaaggaca 3540acagggagaa gatcgagaaa attctgacgt tccgcatccc
gtactacgtg ggccctctcg 3600cgcgcgggaa cagccggttc gcctggatga
ctcggaagtc ggaggagacg atcacgccgt 3660ggaacttcga ggaggtggtg
gacaagggcg cctccgccca gtcgttcatc gagcgcatga 3720cgaacttcga
taaaaatctg cccaatgaaa aagtgctccc gaagcacagc ctcctctacg
3780agtacttcac ggtgtacaac gagctcacga aggtgaagta cgtgaccgag
ggtatgcgga 3840agccggcgtt cctgagcggc gagcagaaga aggccatcgt
ggacctcctc ttcaagacga 3900accggaaagt caccgtgaag caattaaagg
aggactactt caagaaaata gagtgcttcg 3960acagcgtcga gatctcgggc
gtcgaggaca ggttcaacgc gtcgctgggc acataccacg 4020acctcctcaa
gatcattaaa gacaaggact tcctggacaa cgaggagaac gaggacatcc
4080tcgaggacat cgtgctgacc ctcaccctgt ttgaggaccg ggagatgatc
gaggagcgcc 4140tcaagacgta cgctcacctt ttcgacgaca aggtgatgaa
acagctgaag cggcgccgct 4200acaccggatg gggccggctc tcccgcaagc
tcattaatgg gatcagggac aagcagtccg 4260gcaagaccat actcgatttc
ctgaagagcg acggcttcgc caaccggaac ttcatgcagc 4320tcatccacga
cgactccctc actttcaagg aggacatcca gaaggcccag gtcagcggac
4380agggcgactc gctccacgaa cacatcgcca acctggccgg gtcgcctgcg
attaaaaagg 4440gaatccttca gaccgtcaag gtcgtggacg agctggtgaa
ggtgatgggc aggcacaagc 4500ccgaaaatat cgtcattgag atggcccggg
agaaccagac cacgcagaaa ggccagaaga 4560acagccggga gcgcatgaaa
cggatcgagg agggtatcaa ggagctgggc tcgcagatcc 4620tcaaggagca
ccctgtggaa aatacccagc tgcagaatga aaagctctac ctctactacc
4680tccagaacgg ccgcgacatg tacgtggacc aggagctgga cattaatcgc
ctctcggact 4740acgacgtcga ccacatcgtc ccgcagtcct tcctgaagga
cgacagcatc gacaacaagg 4800tcttgacccg ctccgataaa aatcgcggga
agtccgacaa cgtgccgtcg gaggaggtgg 4860tcaagaagat gaaaaactac
tggcgccagc tgctcaacgc caagctaatc acgcagcgca 4920agttcgacaa
cctcaccaag gccgaacgcg gcggtctctc cgagcttgat aaggctgggt
4980tcatcaagag acagctggtg gagacccggc agatcaccaa gcatgtcgcc
cagatcctgg 5040actcgcgcat gaatactaag tacgatgaaa acgacaagct
catccgcgag gtgaaggtga 5100tcaccctgaa gagcaagctg gtctcggact
tccggaagga cttccagttc tacaaggtcc 5160gggagatcaa caactaccac
cacgcgcacg acgcctacct gaacgcggtg gtgggcacag 5220cccttataaa
gaagtaccct aagctcgagt ccgagttcgt gtacggcgac tacaaggtgt
5280acgacgtccg caagatgatc gcgaagagcg agcaggagat cgggaaggcc
accgcaaaat 5340acttcttcta ctccaacatc atgaacttct tcaagaccga
gatcaccctg gccaacgggg 5400agatccgcaa gcgcccgctg attgagacga
acggagagac aggcgagata gtctgggaca 5460agggcaggga cttcgccacc
gtgcgcaagg ttctgtccat gccgcaggtg aacatcgtga 5520agaagactga
ggtgcagaca ggcggcttct cgaaggagtc catcctgccc aagcggaaca
5580gcgacaagct catcgcgcgg aagaaggact gggaccctaa aaaatatggc
gggttcgact 5640cgcccaccgt ggcttactcg gtcctcgtgg tggccaaggt
cgagaagggc aaaagcaaga 5700agctgaagag cgtcaaggag ctcctcggca
tcaccatcat ggagcggtcc agcttcgaga 5760agaacccgat cgacttcctc
gaggcgaagg gatataagga ggtgaagaag gacctcatca 5820ttaaactgcc
gaagtactcg ctattcgaac tggagaatgg tcgcaagagg atgctcgcga
5880gcgctggcga gctgcagaaa gggaacgagc tggctctccc gagcaagtac
gtcaacttcc 5940tctacctggc ctcccactat gaaaagctca agggctcgcc
ggaggacaac gagcagaagc 6000agctgttcgt cgagcagcac aagcattacc
tcgacgagat catcgagcag atctcggagt 6060tcagcaagcg cgtgatcctg
gccgacgcca acctcgacaa ggtgctgtcc gcatataaca 6120agcaccgcga
caaaccaata cgggagcagg ccgaaaatat catccacctg ttcaccctca
6180cgaacctggg cgcccccgcc gcgttcaagt acttcgacac aaccatcgac
cgcaagcggt 6240acacgagcac gaaggaggtg ctggacgcca cgttgattca
ccagtccatc acgggcctgt 6300atgaaacaag gatcgatctc agccagctcg
gcggcgacta ggtaccacat ggttaaccta 6360gacttgtcca tcttctggat
tggccaactt aattaatgta tgaaataaaa ggatgcacac 6420atagtgacat
gctaatcact ataatgtggg catcaaagtt gtgtgttatg tgtaattact
6480agttatctga ataaaagaga aagagatcat ccatatttct tatcctaaat
gaatgtcacg 6540tgtctttata attctttgat gaaccagatg catttcatta
accaaatcca tatacatata 6600aatattaatc atatataatt aatatcaatt
gggttagcaa aacaaatcta gtctaggtgt 6660gttttgcgaa ttgcggc
6677194100DNAArtificial sequenceDNA version of guide RNA (EPSPS
sgRNA) 194gcagtaacag ctgctgtcaa gttttagagc tagaaatagc aagttaaaat
aaggctagtc 60cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt
1001953708DNAArtificial sequenceEPSPS polynucleotide template
195ctgcagccca tcaaggagat ctccggcacc gtcaagctgc cggggtccaa
gtcgctttcc 60aacaggatcc tcctgctcgc cgccctgtcc gaggtgagcg attttggtgc
ttgctgcgct 120gccctgtctc actgctacct aaatgttttg cctgtcgaat
accatggatt ctcggtgtaa 180tccatctcac gatcagatgc accgcatgtc
gcatgcctag ctctctctaa tttgtctagt 240agtttgtata cggattaaga
ttgataaatc ggtaccgcaa aagctaggtg taaataaaca 300ctacaaaatt
ggatgttccc ctatcggcct gtactcggct actcgttctt gtgatggcat
360gttatttctt cttggtgttt ggtgaactcc cttatgaaat ttgggcgcaa
agaaatcgcc 420ctcaagggtt gatcttatgc catcgtcatg ataaacagtg
aagcacggat gatcctttac 480gttgttttta acaaactttg tcagaaaact
agcaatgtta acttcttaat gatgatttca 540caacaaaaaa ggtaaccttg
ctactaacat aacaaaagac ttgttgctta ttaattatat 600gtttttttaa
tctttgatca ggggacaaca gtggttgata acctgttgaa cagtgaggat
660gtccactaca tgctcggggc cttgaggact cttggtctct ctgtcgaagc
ggacaaagct 720gccaaaagag ctgtagttgt tggctgtggt ggaaagttcc
cagttgagga tgctaaagag 780gaagtgcagc tcttcttggg gaatgctgga
atcgcaatgc ggtcattgac agcagctgtt 840actgctgctg gtggaaatgc
aacgtatgtt tcctctctct ctctacaata cttgttggag 900ttagtatgaa
acccatgtgt atgtctagtg gcttatggtg tattggtttt tgaacttcag
960ttacgtgctt gatggagtac caagaatgag ggagagaccc attggcgact
tggttgtcgg 1020attgaagcag cttggtgcag atgttgattg tttccttggc
actgactgcc cacctgttcg 1080tgtcaatgga atcggagggc tacctggtgg
caaggttagt tactaagggc cacatgttac 1140attcttctgt aaatggtaca
actattgtcg agcttttgca tttgtaagga aaacattgat 1200tgatctgaat
ttgatgctac accacaaaat atctacaaat ggtcatccct aactagcaaa
1260ccatgtctcc attaagctca atgaagtaat acttggcatg tgtttatcaa
cttaatttcc 1320atcttctggg gtattgcctg ttttctagtc taatagcatt
tgtttttaga attagctctt 1380acaactgtta tgttctacag gtcaagctgt
ctggctccat cagcagtcag tacttgagtg 1440ccttgctgat ggctgctcct
ttggctcttg gggatgtgga gattgaaatc attgataaat 1500taatctccat
tccctacgtc gaaatgacat tgagattgat ggagcgtttt ggtgtgaaag
1560cagagcattc tgatagctgg gacagattct acattaaggg aggtcaaaaa
tacaagtaag 1620ctctgtaatg tatttcacta ctttgatgcc aatgtttcag
ttttcagttt tccaaacagt 1680cgcatcaata tttgaataga tgcactgtag
aaaaaaatca ttgcagggaa aaactagtac 1740tgagtatttt gactgtaaat
tatttaacca gtcggaatat agtcagtcta ttggagtcaa 1800gagcgtgaac
cgaaatagcc agttaattat cccattatac agaggacaac catgtatact
1860attgaaactt ggtttaagag aatctaggta gctggactcg tagctgcttg
gcatggatac 1920cttcttatct ttaggaaaag acacttgatt ttttttctgt
ggccctctat gatgtgtgaa 1980cctgcttctc tattgcttta gaaggatata
tctatgtcgt tatgcaacat gcttccctta 2040gtcatttgta ctgaaatcag
tttcataagt tcgttagtgg ttccctaaac gaaaccttgt 2100ttttctttgc
aatcaacagg tcccctaaaa atgcctatgt tgaaggtgat gcctcaagcg
2160caagctattt cttggctggt gctgcaatta ctggagggac tgtgactgtg
gaaggttgtg 2220gcaccaccag tttgcaggta aagatttctt ggctggtgct
acgataactg cttttgtctt 2280tttggtttca gcattgttct cagagtcact
aaataacatt atcatctgca aacgtcaaat 2340agacatactt aggtgaatgg
atattcatgt aaccgtttcc ttacaaattt gctgaaacct 2400cagggtgatg
tgaagtttgc tgaggtactg gagatgatgg gagcgaaggt tacatggacc
2460gagactagcg taactgttac tggcccaccg cgggagccat ttgggaggaa
acacctcaag 2520gcgattgatg tcaacatgaa caagatgcct gatgtcgcca
tgactcttgc tgtggttgcc 2580ctctttgccg atggcccgac agccatcaga
gacggtaaaa cattctcagc cctacaacca 2640tgcctcttct acatcactac
ttgacaagac taaaaactat tggctcgttg gcagtggctt 2700cctggagagt
aaaggagacc gagaggatgg ttgcgatccg gacggagcta accaaggtaa
2760ggctacatac ttcacatgtc tcacgtcgtc tttccatagc tcgctgcctc
ttagcggctt 2820gcctgcggtc gctccatcct cggttgctgt ctgtgttttc
cacagctggg agcatctgtt 2880gaggaagggc cggactactg catcatcacg
ccgccggaga agctgaacgt gacggcgatc 2940gacacgtacg acgaccacag
gatggccatg gccttctccc ttgccgcctg tgccgaggtc 3000cccgtgacca
tccgggaccc tgggtgcacc cggaagacct tccccgacta cttcgatgtg
3060ctgagcactt tcgtcaagaa ttaataaagc gtgcgatact accacgcagc
ttgattgaag 3120tgataggctt gtgctgagga aatacatttc ttttgttctg
ttttttctct ttcacgggat 3180taagttttga gtctgtaacg ttagttgttt
gtagcaagtt tctatttcgg atcttaagtt 3240tgtgcactgt aagccaaatt
tcatttcaag agtggttcgt tggaataata agaataataa 3300attacgtttc
agtggctgtc aagcctgctg ctacgtttta ggagatggca ttagacattc
3360atcatcaaca acaataaaac cttttagcct caaacaataa tagtgaagtt
attttttagt 3420cctaaacaag ttgcattagg atatagttaa aacacaaaag
aagctaaagt tagggtttag 3480acatgtggat attgttttcc atgtatagta
tgttctttct ttgagtctca tttaactacc 3540tctacacata ccaactttag
ttttttttct acctcttcat gttactatgg tgccttctta 3600tcccactgag
cattggtata tttagaggtt tttgttgaac atgcctaaat catctcaatc
3660aacgatggac aatcttttct tcgattgagc tgaggtacgt catctaga
370819615DNAArtificial sequenceTIPS nucleotide modifications
196atcgcaatgc ggtca 1519719DNAArtificial sequencePrimer Seqeunce-1
F-E2 197ccgaggagat cgtgctgca 1919820DNAArtificial sequencePrimer
Seqeunce-2 F-E2 198caatggccgc attgcagttc 2019919DNAArtificial
sequencePrimer Seqeunce-1 F-T 199ccgaggagat cgtgctgca
1920020DNAArtificial sequencePrimer Seqeunce-2 F-T 200tgaccgcatt
gcgattccag 2020124DNAArtificial sequencePrimer Seqeunce-1 H-T
201tccaagtcgc tttccaacag gatc 2420220DNAArtificial sequencePrimer
Seqeunce-2 H-T 202tgaccgcatt gcgattccag 2020319DNAArtificial
sequencePrimer Seqeunce-1 F-E3 203ccgaggagat cgtgctgca
1920424DNAArtificial sequencePrimer Seqeunce-2 F-E3 204accaagctgc
ttcaatccga caac 2420563DNAArtificial sequenceDNA fragment with
intact Cas target sequence 205ggggaatgct ggaactgcaa tgcggccatt
gacagcagct gttactgctg ctggtggaaa 60tgc 6320660DNAArtificial
sequenceDNA fragment with mutated Cas target sequence 206ggggaatgct
ggaactgcaa tgcggccatt ggcagctgtt actgctgctg gtggaaatgc
6020750DNAArtificial sequenceDNA fragment with mutated Cas target
sequence 207ggggaatgct ggaactgcac agcagctgtt actgctgctg gtggaaatgc
5020833DNAArtificial sequenceDNA fragment with mutated Cas target
sequence 208ggggaatgct gttactgctg ctggtggaaa tgc
3320951DNAArtificial sequenceTIPS edited EPSPS nucleotide sequence
fragment 209aatgctggaa tcgcaatgcg gtcattgaca gcagctgtta ctgctgctgg
t 5121051DNAArtificial sequenceWild-type epsps nucleotide sequence
fragment 210aatgctggaa ctgcaatgcg gccattgaca gcagctgtta ctgctgctgg
t 512115124DNAZea mays 211atggcggcca tggcgaccaa ggccgccgcg
ggcaccgtgt cgctggacct cgccgcgccg 60ccggcggcgg cagcggcggc ggcggtgcag
gcgggtgccg aggagatcgt gctgcagccc 120atcaaggaga tctccggcac
cgtcaagctg ccggggtcca agtcgctttc caacaggatc 180ctcctgctcg
ccgccctgtc cgaggtgagc gattttggtg cttgctgcgc tgccctgtct
240cactgctacc taaatgtttt gcctgtcgaa taccatggat tctcggtgta
atccatctca 300cgatcagatg caccgcatgt cgcatgccta gctctctcta
atttgtctag tagtttgtat 360acggattaag attgataaat cggtaccgca
aaagctaggt gtaaataaac actacaaaat 420tggatgttcc cctatcggcc
tgtactcggc tactcgttct tgtgatggca tgttatttct 480tcttggtgtt
tggtgaactc ccttatgaaa tttgggcgca aagaaatcgc cctcaagggt
540tgatcttatg ccatcgtcat gataaacagt gaagcacgga tgatccttta
cgttgttttt 600aacaaacttt gtcagaaaac tagcaatgtt aacttcttaa
tgatgatttc acaacaaaaa 660aggtaacctt gctactaaca taacaaaaga
cttgttgctt attaattata tgttttttta 720atctttgatc aggggacaac
agtggttgat aacctgttga acagtgagga tgtccactac 780atgctcgggg
ccttgaggac tcttggtctc tctgtcgaag cggacaaagc tgccaaaaga
840gctgtagttg ttggctgtgg tggaaagttc ccagttgagg atgctaaaga
ggaagtgcag 900ctcttcttgg ggaatgctgg aactgcaatg cggccattga
cagcagctgt tactgctgct 960ggtggaaatg caacgtatgt ttcctctctc
tctctacaat acttgttgga gttagtatga 1020aacccatgtg tatgtctagt
ggcttatggt gtattggttt ttgaacttca gttacgtgct 1080tgatggagta
ccaagaatga gggagagacc cattggcgac ttggttgtcg gattgaagca
1140gcttggtgca gatgttgatt gtttccttgg cactgactgc ccacctgttc
gtgtcaatgg 1200aatcggaggg ctacctggtg gcaaggttag ttactaaggg
ccacatgtta cattcttctg 1260taaatggtac aactattgtc gagcttttgc
atttgtaagg aaaacattga ttgatctgaa 1320tttgatgcta caccacaaaa
tatctacaaa tggtcatccc taactagcaa accatgtctc 1380cattaagctc
aatgaagtaa tacttggcat gtgtttatca acttaatttc catcttctgg
1440ggtattgcct gttttctagt ctaatagcat ttgtttttag aattagctct
tacaactgtt 1500atgttctaca ggtcaagctg tctggctcca tcagcagtca
gtacttgagt gccttgctga 1560tggctgctcc tttggctctt ggggatgtgg
agattgaaat cattgataaa ttaatctcca 1620ttccctacgt cgaaatgaca
ttgagattga tggagcgttt tggtgtgaaa gcagagcatt 1680ctgatagctg
ggacagattc tacattaagg gaggtcaaaa atacaagtaa gctctgtaat
1740gtatttcact actttgatgc caatgtttca gttttcagtt ttccaaacag
tcgcatcaat 1800atttgaatag atgcactgta gaaaaaaatc attgcaggga
aaaactagta ctgagtattt 1860tgactgtaaa ttatttaacc agtcggaata
tagtcagtct attggagtca agagcgtgaa 1920ccgaaatagc cagttaatta
tcccattata cagaggacaa ccatgtatac tattgaaact 1980tggtttaaga
gaatctaggt agctggactc gtagctgctt ggcatggata ccttcttatc
2040tttaggaaaa gacacttgat tttttttctg tggccctcta tgatgtgtga
acctgcttct 2100ctattgcttt agaaggatat atctatgtcg ttatgcaaca
tgcttccctt agtcatttgt 2160actgaaatca gtttcataag ttcgttagtg
gttccctaaa cgaaaccttg tttttctttg 2220caatcaacag gtcccctaaa
aatgcctatg ttgaaggtga tgcctcaagc gcaagctatt 2280tcttggctgg
tgctgcaatt actggaggga ctgtgactgt ggaaggttgt ggcaccacca
2340gtttgcaggt aaagatttct tggctggtgc tacgataact gcttttgtct
ttttggtttc 2400agcattgttc tcagagtcac taaataacat tatcatctgc
aaacgtcaaa tagacatact 2460taggtgaatg gatattcatg taaccgtttc
cttacaaatt tgctgaaacc tcagggtgat 2520gtgaagtttg ctgaggtact
ggagatgatg ggagcgaagg ttacatggac cgagactagc 2580gtaactgtta
ctggcccacc gcgggagcca tttgggagga aacacctcaa ggcgattgat
2640gtcaacatga acaagatgcc tgatgtcgcc atgactcttg ctgtggttgc
cctctttgcc 2700gatggcccga cagccatcag agacggtaaa acattctcag
ccctacaacc atgcctcttc 2760tacatcacta cttgacaaga ctaaaaacta
ttggctcgtt ggcagtggct tcctggagag 2820taaaggagac
cgagaggatg gttgcgatcc ggacggagct aaccaaggta aggctacata
2880cttcacatgt ctcacgtcgt ctttccatag ctcgctgcct cttagcggct
tgcctgcggt 2940cgctccatcc tcggttgctg tctgtgtttt ccacagctgg
gagcatctgt tgaggaaggg 3000ccggactact gcatcatcac gccgccggag
aagctgaacg tgacggcgat cgacacgtac 3060gacgaccaca ggatggccat
ggccttctcc cttgccgcct gtgccgaggt ccccgtgacc 3120atccgggacc
ctgggtgcac ccggaagacc ttccccgact acttcgatgt gctgagcact
3180ttcgtcaaga attaataaag cgtgcgatac taccacgcag cttgattgaa
gtgataggct 3240tgtgctgagg aaatacattt cttttgttct gttttttctc
tttcacggga ttaagttttg 3300agtctgtaac gttagttgtt tgtagcaagt
ttctatttcg gatcttaagt ttgtgcactg 3360taagccaaat ttcatttcaa
gagtggttcg ttggaataat aagaataata aattacgttt 3420cagtggctgt
caagcctgct gctacgtttt aggagatggc attagacatt catcatcaac
3480aacaataaaa ccttttagcc tcaaacaata atagtgaagt tattttttag
tcctaaacaa 3540gttgcattag gatatagtta aaacacaaaa gaagctaaag
ttagggttta gacatgtgga 3600tattgttttc catgtatagt atgttctttc
tttgagtctc atttaactac ctctacacat 3660accaacttta gttttttttc
tacctcttca tgttactatg gtgccttctt atcccactga 3720gcattggtat
atttagaggt ttttgttgaa catgcctaaa tcatctcaat caacgatgga
3780caatcttttc ttcgattgag ctgaggtacg tcatctagag gataggacct
tgagaatatg 3840tgtccgtcaa tagctaaccc tctactaatt ttttcaatca
agcaacctat tggcttgact 3900ttaattcgta ccggcttcta ctacttctac
agtattttgt ctctataaat tgcagctaca 3960acagtcagaa cggctggctt
taaaatcaaa tggcctaagg atcattgaaa ggcatcttag 4020caatgtctaa
aattattacc ttctctagac gttgatatct ttgctccgga ttcgatccct
4080tgttgtatga ccacaaatcc aacaccaaat acgcatttct gcaacacacc
caaacacccc 4140ttccaaataa gtggaatggt tgagaaattt gctattttga
ttaaatattg gtgaaggggc 4200aaggctgagg aaacgagacg aaggttcctt
gacagctgaa aaatggaaca ctctagaggc 4260ggagggagcg aggcgagctg
tgtgaattgc cacccattga ttaagaatcc aacaacttga 4320ctagcaaatg
ccgacatggg tagcctacaa aggcgagttt tggagctggt ttcgtaataa
4380ggaaatttct caaccaacta ctttccttag aaaagagttg cttgaccgga
tcaacatctc 4440cccctaaacc ccttggaggg ggagggggct aagattttaa
tctacaagtt agatctaact 4500gtccacctca atccccctca aggaggtttt
tgtattattt gttagtgtag aatgataaag 4560tggatgtatt gataggagat
ggggtacaca tatttatagg gactcaaccc taaccctaat 4620gggtcggcag
cccaacagtg gtgtccggcc cacacacaca ctcacacaca cagtctaaca
4680tcccccgcag tcgcaacggg gacaccacac acgatgagac tggagtagag
gccgaaggta 4740ggagccgacg ggttgaaatc ccccctagtc gcagcgtcgt
gatagtacga atgttgcggc 4800tggagtagag accggtgtgt gctccaagaa
gacgatagcc cctagatgcc gaggtagccg 4860aagtcgaggt ggtcgcggtc
ggaagacgcg cagcaaaagc ctgatcttcg ggatggtcga 4920cgttcgagcg
tcaacgatcg gtagggcgac acaataaaag ggcaccagca ggtcgacctt
4980cctgcttctt cgatcgtcca gacgtcaagg agcctcgcta gggaggccga
cggcagcgca 5040cgcggctacg ccggtcatgg tgtcctcacc cgcggcagaa
aagaagggga atgtcggatc 5100cgaccgagaa ggccacggca gcga
51242123387DNAS. thermophilus 212atgagtgact tagttttagg acttgatatc
ggtataggtt ctgttggtgt aggtatcctt 60aacaaagtga caggagaaat tatccataaa
aactcacgca tcttcccagc agctcaagca 120gaaaataacc tagtacgtag
aacgaatcgt caaggaagac gcttgacacg acgtaaaaaa 180catcgtatag
ttcgtttaaa tcgtctattt gaggaaagtg gattaatcac cgattttacg
240aagatttcaa ttaatcttaa cccatatcaa ttacgagtta agggcttgac
cgatgaattg 300tctaatgaag aactgtttat cgctcttaaa aatatggtga
aacaccgtgg gattagttac 360ctcgatgatg ctagtgatga cggaaattca
tcagtaggag actatgcaca aattgttaag 420gaaaatagta aacaattaga
aactaagaca ccgggacaga tacagttgga acgctaccaa 480acatatggtc
aattacgtgg tgattttact gttgagaaag atggcaaaaa acatcgcttg
540attaatgtct ttccaacatc agcttatcgt tcagaagcct taaggatact
gcaaactcaa 600caagaattta atccacagat tacagatgaa tttattaatc
gttatctcga aattttaact 660ggaaaacgga aatattatca tggacccgga
aatgaaaagt cacggactga ttatggtcgt 720tacagaacga gtggagaaac
tttagacaat atttttggaa ttctaattgg gaaatgtaca 780ttttatccag
aagagtttag agcagcaaaa gcttcctaca cggctcaaga attcaatttg
840ctaaatgatt tgaacaatct aacagttcct actgaaacca aaaagttgag
caaagaacag 900aagaatcaaa tcattaatta tgtcaaaaat gaaaaggcaa
tggggccagc gaaacttttt 960aaatatatcg ctaagttact ttcttgtgat
gttgcagata tcaagggata ccgtatcgac 1020aaatcaggta aggctgagat
tcatactttc gaagcctatc gaaaaatgaa aacgcttgaa 1080accttagata
ttgaacaaat ggatagagaa acgcttgata aattagccta tgtcttaaca
1140ttaaacactg agagggaagg tattcaagaa gccttagaac atgaatttgc
tgatggtagc 1200tttagccaga agcaagttga cgaattggtt caattccgca
aagcaaatag ttccattttt 1260ggaaaaggat ggcataattt ttctgtcaaa
ctgatgatgg agttaattcc agaattgtat 1320gagacgtcag aagagcaaat
gactatcctg acacgacttg gaaaacaaaa acgacttcgt 1380cttcaaataa
aacaaaatat ttcaaataaa acaaaatata tagatgagaa actattaact
1440gaagaaatct ataatcctgt tgttgctaag tctgttcgcc aggctataaa
aatcgtaaat 1500gcggcgatta aagaatacgg agactttgac aatattgtca
tcgaaatggc tcgtgaaaca 1560aatgaagatg atgaaaagaa agctattcaa
aagattcaaa aagccaacaa agatgaaaaa 1620gatgcagcaa tgcttaaggc
tgctaaccaa tataatggaa aggctgaatt accacatagt 1680gttttccacg
gtcataagca attagcgact aaaatccgcc tttggcatca gcaaggagaa
1740cgttgccttt atactggtaa gacaatctca atccatgatt tgataaataa
tcctaatcag 1800tttgaagtag atcatatttt acctctttct atcacattcg
atgatagcct tgcaaataag 1860gttttggttt atgcaactgc taaccaagaa
aaaggacaac gaacacctta tcaggcttta 1920gatagtatgg atgatgcgtg
gtctttccgt gaattaaaag cttttgtacg tgagtcaaaa 1980acactttcaa
acaagaaaaa agaatacctc cttacagaag aagatatttc aaagtttgat
2040gttcgaaaga aatttattga acgaaatctt gtagatacaa gatacgcttc
aagagttgtc 2100ctcaatgccc ttcaagaaca ctttagagct cacaagattg
atacaaaagt ttccgtggtt 2160cgtggccaat ttacatctca attgagacgc
cattggggaa ttgagaagac tcgtgatact 2220tatcatcacc atgctgtcga
tgcattgatt attgccgcct caagtcagtt gaatttgtgg 2280aaaaaacaaa
agaataccct tgtaagttat tcagaagaac aactccttga tattgaaaca
2340ggtgaactta ttagtgatga tgagtacaag gaatctgtgt tcaaagcccc
ttatcaacat 2400tttgttgata cattgaagag taaagaattt gaagacagta
tcttattctc atatcaagtg 2460gattctaagt ttaatcgtaa aatatcagat
gccactattt atgcgacaag acaggctaaa 2520gtgggaaaag ataagaagga
tgaaacttat gtcttaggga aaatcaaaga tatctatact 2580caggatggtt
atgatgcctt tatgaagatt tataagaagg ataagtcaaa attcctcatg
2640tatcgtcacg acccacaaac ctttgagaaa gttatcgagc caattttaga
gaactatcct 2700aataagcaaa tgaatgaaaa aggaaaagag gtaccatgta
atcctttcct aaaatataaa 2760gaagaacatg gctatattcg taaatatagt
aaaaaaggca atggtcctga aatcaagagt 2820cttaaatact atgatagtaa
gcttttaggt aatcctattg atattactcc agagaatagt 2880aaaaataaag
ttgtcttaca gtcattaaaa ccttggagaa cagatgtcta tttcaataag
2940gctactggaa aatacgaaat ccttggatta aaatatgctg atctacaatt
tgagaaaggg 3000acaggaacat ataagatttc ccaggaaaaa tacaatgaca
ttaagaaaaa agagggtgta 3060gattctgatt cagaattcaa gtttacactt
tataaaaatg atttgttact cgttaaagat 3120acagaaacaa aagaacaaca
gcttttccgt tttctttctc gaactttacc taaacaaaag 3180cattatgttg
aattaaaacc ttatgataaa cagaaatttg aaggaggtga ggcgttaatt
3240aaagtgttgg gtaacgttgc taatggtggt caatgcataa aaggactagc
aaaatcaaat 3300atttctattt ataaagtaag aacagatgtc ctaggaaatc
agcatatcat caaaaatgag 3360ggtgataagc ctaagctaga tttttaa
33872133369DNAS. thermophilus 213atgagtgact tagttttagg acttgatatc
ggtataggtt ctgttggtgt aggtatcctt 60aacaaagtga caggagaaat tatccataaa
aactcacgca tcttcccagc agctcaagca 120gaaaataacc tagtacgtag
aacgaatcgt caaggaagac gcttgacacg acgtaaaaaa 180catcgtatag
ttcgtttaaa tcgtctattt gaggaaagtg gattaatcac cgattttacg
240aagatttcaa ttaatcttaa cccatatcaa ttacgagtta agggcttgac
cgatgaattg 300tctaatgaag aactgtttat cgctcttaaa aatatggtga
aacaccgtgg gattagttac 360ctcgatgatg ctagtgatga cggaaattca
tcagtaggag actatgcaca aattgttaag 420gaaaatagta aacaattaga
aactaagaca ccgggacaga tacagttgga acgctaccaa 480acatatggtc
aattacgtgg tgattttact gttgagaaag atggcaaaaa acatcgcttg
540attaatgtct ttccaacatc agcttatcgt tcagaagcct taaggatact
gcaaactcaa 600caagaattta attcacagat tacagatgaa tttattaatc
gttatctcga aattttaact 660ggaaaacgga aatattatca tggacccgga
aatgaaaagt cacggactga ttatggtcgt 720tacagaacga atggagaaac
tttagacaat atttttggaa ttctaattgg gaaatgtaca 780ttttatccag
acgagtttag agcagcaaaa gcttcctaca cggctcaaga attcaatttg
840ctaaatgatt tgaacaatct aacagttcct actgaaacca aaaagttgag
caaagaacag 900aagaatcaaa tcattaatta tgtcaaaaat gaaaaggtaa
tggggccagc gaaacttttt 960aaatatatcg ctaaattact ttcttgtgat
gttgcagata tcaagggaca ccgtatcgac 1020aaatcaggta aggctgagat
tcatactttc gaagcctatc gaaaaatgaa aacgcttgaa 1080accttagata
ttgagcaaat ggatagagaa acgcttgata aattagccta tgtcttaaca
1140ttaaacactg agagggaagg tattcaagaa gctttagaac atgaatttgc
tgatggtagc 1200tttagccaga agcaagttga cgaattggtt caattccgca
aagcaaatag ttccattttt 1260ggaaaaggat ggcataattt ttctgtcaaa
ctgatgatgg agttaattcc agaattgtat 1320gagacgtcag aagagcaaat
gactatcctg acacgacttg gaaaacaaaa aacaacttcg 1380tcttcaaata
aaacaaaata tatagatgag aaactattaa ctgaagaaat ctataatcct
1440gttgttgcta agtctgttcg ccaggctata aaaatcgtaa atgcggcgat
taaagaatac 1500ggagactttg acaatattgt catcgaaatg gctcgtgaaa
caaatgaaga tgatgaaaag 1560aaagctattc aaaagattca aaaagccaac
aaagatgaaa aagatgcagc aatgcttaag 1620gctgctaacc aatataatgg
aaaggctgaa ttaccacata gtgttttcca cggtcataag 1680caattagcga
ctaaaatccg cctttggcat cagcaaggag aacgttgcct ttatactggt
1740aagacaatct caatccatga tttgataaat aatcctaatc agtttgaagt
agatcatatt 1800ttacctcttt ctatcacatt cgatgatagc cttgcaaata
aggttttggt ttatgcaact 1860gctaaccaag aaaaaggaca acgaacacct
tatcaggctt tagatagtat ggatgatgcg 1920tggtctttcc gtgaattaaa
agcttttgta cgtgagtcaa aaacactttc aaacaagaaa 1980aaagaatacc
tccttacaga agaagatatt tcaaagtttg atgttcgaaa gaaatttatt
2040gaacgaaatc ttgtagatac aagatacgct tcaagagttg tcctcaatgc
ccttcaagaa 2100cactttagag ctcacaagat tgatacaaaa gtttccgtgg
ttcgtggcca atttacatct 2160caattgagac gccattgggg aattgagaag
actcgtgata cttatcatca ccatgctgtc 2220gatgcattga ttattgccgc
ctcaagtcag ttgaatttgt ggaaaaaaca aaagaatacc 2280cttgtaagtt
attcagaaga acaactcctt gatattgaaa caggtgaact tattagtgat
2340gatgagtaca aggaatctgt gttcaaagcc ccttatcaac attttgttga
tacattgaag 2400agtaaagaat ttgaagacag tatcttattc tcatatcaag
tggattctaa gtttaatcgt 2460aaaatatcag atgccactat ttatgcgaca
agacaggcta aagtgggaaa agataagaag 2520gatgaaactt atgtcttagg
gaaaatcaaa gatatctata ctcaggatgg ttatgatgcc 2580tttatgaaga
tttataagaa ggataagtca aaattcctca tgtatcgtca cgacccacaa
2640acctttgaga aagttatcga gccaatttta gagaactatc ctaataagga
aatgaatgaa 2700aaagggaaag aagtaccatg taatcctttc ctaaaatata
aagaagaaca tggctatatt 2760cgtaaatata gtaaaaaagg caatggtcct
gaaatcaaga gtcttaaata ctatgatagt 2820aagcttttag gtaatcctat
tgatattact ccagagaata gtaaaaataa agttgtctta 2880cagtcattaa
aaccttggag aacagatgtc tatttcaata aaaatactgg taaatatgaa
2940attttaggac tgaaatatgc tgatttacaa tttgaaaaga agacaggaac
atataagatt 3000tcccaggaaa aatacaatgg cattatgaaa gaagagggtg
tagattctga ttcagaattc 3060aagtttacac tttataaaaa tgatttgtta
ctcgttaaag atacagaaac aaaagaacaa 3120cagcttttcc gttttctttc
tcgaactatg cctaatgtga aatattatgt agagttaaag 3180ccttattcaa
aagataaatt tgagaagaat gagtcactta ttgaaatttt aggttctgca
3240gataagtcag gacgatgtat aaaagggcta ggaaaatcaa atatttctat
ttataaggta 3300agaacagatg tcctaggaaa tcagcatatc atcaaaaatg
agggtgataa gcctaagcta 3360gatttttaa 33692144113DNAS. agalactiae
214atgaataagc catattcaat aggccttgac atcggtacta attccgtcgg
atggagcatt 60attacagatg attataaagt acctgctaag aagatgagag ttttagggaa
cactgataaa 120gaatatatta agaagaatct cataggtgct ctgctttttg
atggcgggaa tactgctgca 180gatagacgct tgaagcgaac tgctcgtcgt
cgttatacac gtcgtagaaa tcgtattcta 240tatttacaag aaatttttgc
agaggaaatg agtaaagttg atgatagttt ctttcatcga 300ttagaggatt
cttttctagt tgaggaagat aagagaggga gcaagtatcc tatctttgca
360acattgcagg aagagaaaga ttatcatgaa aaattttcga caatctatca
tttgagaaaa 420gaattagctg acaagaaaga aaaagcagac cttcgtctta
tttatattgc tctagctcat 480atcattaaat ttagagggca tttcctaatt
gaggatgata gctttgatgt caggaataca 540gacatttcaa aacaatatca
agatttttta gaaatcttta atacaacttt tgaaaataat 600gatttgttat
ctcaaaacgt tgacgtagag gcaatactaa cagataagat tagcaagtct
660gcgaagaaag atcgtatttt agcgcagtat cctaaccaaa aatctactgg
catttttgca 720gaatttttga aattgattgt cggaaatcaa gctgacttca
agaaatattt caatttggag 780gataaaacgc cgcttcaatt cgctaaggat
agctacgatg aagatttaga aaatcttctt 840ggacagattg gtgatgaatt
tgcagactta ttctcagcag cgaaaaagtt atatgatagt 900gtccttttgt
ctggcattct tacagtaatc gacctcagta ccaaggcgcc actttcagct
960tctatgattc agcgttatga tgaacataga gaggacttga aacagttaaa
acaattcgta 1020aaagcttcat tgccggaaaa atatcaagaa atatttgctg
attcatcaaa agatggctac 1080gctggttata ttgaaggtaa aactaatcaa
gaagcttttt ataaatacct gtcaaaattg 1140ttgaccaagc aagaagatag
cgagaatttt cttgaaaaaa tcaagaatga agatttcttg 1200agaaaacaaa
ggacctttga taatggctca attccacacc aagtccattt gacagagctg
1260aaagctatta tccgccgtca atcagaatac tatcccttct tgaaagagaa
tcaagatagg 1320attgaaaaaa tccttacctt tagaattcct tattatatcg
ggccactagc acgtgagaag 1380agtgattttg catggatgac tcgcaaaaca
gatgacagta ttcgaccttg gaattttgaa 1440gacttggttg ataaagaaaa
atctgcggaa gcttttatcc atcgtatgac caacaatgat 1500ttttatcttc
ctgaagaaaa agttttacca aagcatagtc ttatttatga aaaatttacg
1560gtctataatg agttgactaa ggttagatat aaaaatgagc aaggtgagac
ttattttttt 1620gatagcaata ttaaacaaga aatctttgat ggagtattca
aggaacatcg taaggtatcc 1680aagaagaagt tgctagattt tctggctaaa
gaatatgagg agtttaggat agtagatgtt 1740attggtctag ataaagaaaa
taaagctttc aacgcctcat tgggaactta ccacgatctc 1800gaaaaaatac
tagacaaaga ttttctagat aatccagata atgagtctat tctggaagat
1860atcgtccaaa ctctaacatt atttgaagac agagaaatga ttaagaagcg
tcttgaaaac 1920tataaagatc tttttacaga gtcacaacta aaaaaactct
atcgtcgtca ctatactggc 1980tggggacgat tgtctgctaa gttaatcaat
ggtattcgag ataaagagag tcaaaaaaca 2040atcttggact atcttattga
tgatggtaga tctaatcgca actttatgca gttgataaat 2100gatgatggtc
tatctttcaa atcaattatc agtaaggcac aggctggtag tcattcagat
2160aatctaaaag aagttgtagg tgagcttgca ggtagccctg ctattaaaaa
gggaattcta 2220caaagtttga aaattgttga tgagcttgtt aaagtcatgg
gatacgaacc tgaacaaatt 2280gtggttgaga tggcgcgtga gaatcaaaca
acaaatcaag gtcgtcgtaa ctctcgacaa 2340cgctataaac ttcttgatga
tggcgttaag aatctagcta gtgacttgaa tggcaatatt 2400ttgaaagaat
atcctacgga taatcaagcg ttgcaaaatg aaagactttt cctttactac
2460ttacaaaacg gaagagatat gtatacaggg gaagctctag atattgacaa
tttaagtcaa 2520tatgatattg accacattat tcctcaagct ttcataaaag
atgattctat tgataatcgt 2580gttttggtat catctgctaa aaatcgtgga
aagtcagatg atgttcctag ccttgaaatt 2640gtaaaagatt gtaaagtttt
ctggaaaaaa ttacttgatg ctaagttaat gagtcagcgt 2700aagtatgata
atttgactaa ggcagagcgc ggaggcctaa cttccgatga taaggcaaga
2760tttatccaac gtcagttggt tgagacacga caaattacca agcatgttgc
ccgtatcttg 2820gatgaacgct ttaataatga gcttgatagt aaaggtagaa
ggatccgcaa agttaaaatt 2880gtaaccttga agtcaaattt ggtttcaaat
ttccgaaaag aatttggatt ctataaaatt 2940cgtgaagtta acaattatca
ccatgcacat gatgcctatc ttaatgcagt agttgctaaa 3000gctattctaa
ccaaatatcc tcagttagag ccagaatttg tctacggcga ctatccaaaa
3060tataatagtt acaaaacgcg taaatccgct acagaaaagc tatttttcta
ttcaaatatt 3120atgaacttct ttaaaactaa ggtaacttta gcggatggaa
ccgttgttgt aaaagatgat 3180attgaagtta ataatgatac gggtgaaatt
gtttgggata aaaagaaaca ctttgcgaca 3240gttagaaaag tcttgtcata
ccctcagaac aatatcgtga agaagacaga gattcagaca 3300ggtggtttct
ctaaggaatc aatcttggcg catggtaact cagataagtt gattccaaga
3360aaaacgaagg atatttattt agatcctaag aaatatggag gttttgatag
tccgatagta 3420gcttactctg ttttagttgt agctgatatc aaaaagggta
aagcacaaaa actaaaaaca 3480gttacggaac ttttaggaat taccatcatg
gagaggtcca gatttgagaa aaatccatca 3540gctttccttg aatcaaaagg
ctatttaaat attagggctg ataaactaat tattttgccc 3600aagtatagtc
tgttcgaatt agaaaatggg cgtcgtcgat tacttgctag tgctggtgaa
3660ttacaaaaag gtaatgagct agccttacca acacaattta tgaagttctt
ataccttgca 3720agtcgttata atgagtcaaa aggtaaacca gaggagattg
agaagaaaca agaatttgta 3780aatcaacatg tctcttattt tgatgacatc
cttcaattaa ttaatgattt ttcaaaacga 3840gttattctag cagatgctaa
tttagagaaa atcaataagc tttaccaaga taataaggaa 3900aatatatcag
tagatgaact tgctaataat attatcaatc tatttacttt taccagtcta
3960ggagctccag cagcttttaa attttttgat aaaatagttg atagaaaacg
ctatacatca 4020actaaagaag tacttaattc taccctaatt catcaatcta
ttactggact ttatgaaaca 4080cgtattgatt tgggtaagtt aggagaagat tga
41132154134DNAS. agalactiae 215atgaataagc catattcaat aggccttgac
atcggtacta attccgtcgg atggagcatt 60attacagatg attataaagt acctgctaag
aagatgagag ttttagggaa cactgataaa 120gaatatatta agaagaatct
cataggtgct ctgctttttg atggcgggaa tactgctgca 180gatagacgct
tgaagcgaac tgctcgtcgt cgttatacac gtcgtagaaa tcgtattcta
240tatttacaag aaatttttgc agaggaaatg agtaaagttg atgatagttt
ctttcatcga 300ttagaggatt cttttctagt tgaggaagat aagagaggta
gcaagtatcc tatctttgca 360acaatgcagg aggagaaata ttatcatgaa
aaatttccga caatctatca tttgagaaaa 420gaattggctg acaagaaaga
aaaagcagac cttcgtcttg tttatctggc tctagctcat 480atcattaaat
tcagagggca tttcctaatt gaggatgata gatttgatgt gaggaatacc
540gatattcaaa aacaatatca agccttttta gaaatttttg atactacctt
tgaaaataat 600catttgttat ctcaaaatgt agatgtagaa gcaattctaa
cagataagat tagcaagtct 660gcgaagaagg atcgcatctt agcgcagtat
cctaaccaaa aatctactgg tatttttgca 720gaatttttga aattgattgt
cggaaatcaa gctgacttca agaaacattt caatttggag 780gataaaacac
cgcttcaatt cgctaaggat agctacgatg aagatttaga aaatcttctt
840ggacagattg gtgatgaatt tgcagactta ttctcagtag cgaaaaagct
atatgatagt 900gttcttttat ctggcattct tacagtaact gatctcagta
ccaaggcgcc actttctgcc 960tctatgattc agcgttatga tgaacatcat
gaggacttaa agcatctaaa acaattcgta 1020aaagcttcat tacctgaaaa
ttatcgggaa gtatttgctg attcatcaaa agatggctac 1080gctggctata
ttgaaggcaa aactaatcaa gaagcttttt ataaatatct gttaaaattg
1140ttgaccaaac aagaaggtag cgagtatttt cttgagaaaa ttaagaatga
agattttttg 1200agaaaacaga gaacctttga taatggctca atcccgcatc
aagtccattt gacagaattg 1260agggctatta ttcgacgtca atcagaatac
tatccattct tgaaagagaa tcaagatagg 1320attgaaaaaa tccttacctt
tagaattcct tattatgtcg ggccactagc acgtgagaag 1380agtgattttg
catggatgac tcgcaaaaca gatgacagta ttcgaccttg gaattttgaa
1440gacttggttg ataaagaaaa atctgcggaa gcttttatcc atcgcatgac
caacaatgac 1500ctctatcttc cagaagaaaa agttttacca aagcatagtc
ttatttatga aaaatttact 1560gtttacaatg aattaacgaa ggttagattt
ttggcagaag gctttaaaga ttttcaattt 1620ttaaatagga agcaaaaaga
aactatcttt
aacagcttgt ttaaggaaaa acgtaaagta 1680actgaaaagg atattattag
ttttttgaat aaagttgatg gatatgaagg aattgcaatc 1740aaaggaattg
agaaacagtt taacgctagc ctttcaacct atcatgatct taaaaaaata
1800cttggcaagg atttccttga taatacagat aacgagctta ttttggaaga
tatcgtccaa 1860actctaacct tatttgaaga tagagaaatg attaagaagt
gtcttgacat ctataaagat 1920ttttttacag agtcacagct taaaaagctc
tatcgccgtc actatactgg ctggggacga 1980ttgtctgcta agctaataaa
tggcatccga aataaagaga atcaaaaaac aatcttggac 2040tatcttattg
atgatggaag tgcaaaccga aacttcatgc agttgataaa tgatgatgat
2100ctatcattta aaccaattat tgacaaggca cgaactggta gtcattcgga
taatctgaaa 2160gaagttgtag gtgaacttgc tggtagccct gctattaaaa
aagggattct acaaagtttg 2220aaaatagttg atgagctggt taaagtcatg
ggctatgaac ctgaacaaat cgtggttgaa 2280atggcacgtg agaaccaaac
gacagcaaaa ggattaagtc gttcacgaca acgcttgaca 2340accttgagag
aatctcttgc taatttgaag agtaatattt tggaagagaa aaagcctaag
2400tatgtgaaag atcaagttga aaatcatcat ttatctgatg accgtctttt
cctttactac 2460ttacaaaacg gaagagatat gtatacaaaa aaggctctgg
atattgataa tttaagtcaa 2520tatgatattg accacattat tcctcaagct
ttcataaaag atgattctat tgataatcgt 2580gttttggtat catctgctaa
aaatcgtgga aaatcagatg atgttcctag cattgaaatt 2640gtaaaagctc
gcaaaatgtt ctggaaaaat ttactggatg ctaagttaat gagtcagcgt
2700aagtatgata atttgactaa ggcagagcgc ggaggcctaa cttccgatga
taaggcaaga 2760tttatccaac gtcagttggt tgagactcga caaattacca
agcatgtagc tcgtatcttg 2820gatgaacgct tcaataatga agttgataat
ggtaaaaaga tttgcaaggt taaaattgta 2880accttgaagt caaatttggt
ttcaaatttc cgaaaagaat ttggattcta taaaattcgt 2940gaagttaatg
attatcacca tgcacacgat gcttatctta atgcagtagt tgccaaagct
3000attctaacca aatatccaca gttagagcca gagtttgtct acggaatgta
tagacagaaa 3060aaactttcga aaatcgttca tgaggataag gaagaaaaat
atagtgaagc aaccaggaaa 3120atgtttttct actccaactt gatgaatatg
ttcaaaagag ttgtgaggtt agcagatggt 3180tctattgttg taagaccagt
aatagaaact ggtagatata tgagaaaaac tgcatgggat 3240aaaaagaaac
actttgcgac agttagaaaa gtcttgtcat accctcagaa caatatcgtg
3300aagaagacag agattcagac aggtggtttc tctaaggaat caatcttggc
gcatggtaac 3360tcagataagt tgattccaag aaaaacgaag gatatttatt
tagatcctaa gaaatatgga 3420ggttttgata gtccgatagt agcttactct
gttttagttg tagctgatat caaaaaaggt 3480aaagcacaaa aactaaaaac
agttacggaa cttttaggaa ttaccatcat ggagaggtcc 3540agatttgaga
aaaatccatc agctttcctt gaatcaaaag gttatttaaa tattagggac
3600gataaattaa tgattttacc gaagtatagt ctgttcgaat tagaaaatgg
gcgtcgtcga 3660ttacttgcta gtgctggtga attacaaaaa ggtaacgagc
tagccttacc aacacaattt 3720atgaagttct tataccttgc aagtcgttat
aatgagtcaa aaggtaaacc agaggagatt 3780gagaagaaac aagaatttgt
aaatcaacat gtctcttatt ttgatgacat ccttcaatta 3840attaatgatt
tttcaaaacg agttattcta gcagatgcta atttagagaa aatcaataag
3900ctttaccagg ataataagga aaatatacca gtagatgaac ttgctaataa
tattatcaat 3960ctatttactt ttaccagtct aggagctcca gcagctttta
aattttttga taaaatagtt 4020gatagaaaac gctatacatc aactaaagaa
gtacttaatt ctactctaat ccatcaatct 4080attactggac tttatgaaac
acgtattgat ttgggtaaat taggagaaga ttga 41342164038DNAS. mutans
216atgaaaaaac cttactctat tggacttgat attggaacca attctgttgg
ttgggctgtt 60gtgacagatg actacaaagt tcctgctaag aagatgaagg ttctgggaaa
tacagataaa 120agtcatatcg agaaaaattt gcttggcgct ttattatttg
atagcgggaa tactgcagaa 180gacagacggt taaagagaac tgctcgccgt
cgttacacac gtcgcagaaa tcgtatttta 240tatttgcaag agattttttc
agaagaaatg ggcaaggtag atgatagttt ctttcatcgt 300ttagaggatt
cttttcttgt tactgaggat aaacgaggag agcgccatcc catttttggg
360aatcttgaag aagaagttaa gtatcatgaa aattttccaa ccatttatca
tttgcggcaa 420tatcttgcgg ataatccaga aaaagttgat ttgcgtttag
tttatttggc tttggcacat 480ataattaagt ttagaggtca ttttttaatt
gaaggaaagt ttgatacacg caataatgat 540gtacaaagac tgtttcaaga
atttttagca gtctatgata atacttttga gaatagttcg 600cttcaggagc
aaaatgttca agttgaagaa attctgactg ataaaatcag taaatctgct
660aagaaagata gagttttgaa actttttcct aatgaaaagt ctaatggccg
ctttgcagaa 720tttctaaaac taattgttgg taatcaagct gattttaaaa
agcattttga attagaagag 780aaagcaccat tgcaattttc taaagatact
tatgaagaag agttagaagt actattagct 840caaattggag ataattacgc
agagctcttt ttatcagcaa agaaactgta tgatagtatc 900cttttatcag
ggattttaac agttactgat gttggtacca aagcgccttt atctgcttcg
960atgattcagc gatataatga acatcagatg gatttagctc agcttaaaca
attcattcgt 1020cagaaattat cagataaata taacgaagtt ttttctgatg
tttcaaaaga cggctatgcg 1080ggttatattg atgggaaaac aaatcaagaa
gctttttata aataccttaa aggtctatta 1140aataagattg agggaagtgg
ctatttcctt gataaaattg agcgtgaaga ttttctaaga 1200aagcaacgta
cctttgacaa tggctctatt ccacatcaga ttcatcttca agaaatgcgt
1260gctatcattc gtagacaggc tgaattttat ccgtttttag cagacaatca
agataggatt 1320gagaaattat tgactttccg tattccctac tatgttggtc
cattagcgcg cggaaaaagt 1380gattttgctt ggttaagtcg gaaatcggct
gataaaatta caccatggaa ttttgatgaa 1440atcgttgata aagaatcctc
tgcagaagct tttatcaatc gtatgacaaa ttatgatttg 1500tacttgccaa
atcaaaaagt tcttcctaaa catagtttat tatacgaaaa atttactgtt
1560tacaatgaat taacaaaggt taaatataaa acagagcaag gaaaaacagc
attttttgat 1620gccaatatga agcaagaaat ctttgatggc gtatttaagg
tttatcgaaa agtaactaaa 1680gataaattaa tggatttcct tgaaaaagaa
tttgatgaat ttcgtattgt tgatttaaca 1740ggtctggata aagaaaataa
agtatttaac gcttcttatg gaacttatca tgatttgtgt 1800aaaattttag
ataaagattt tctcgataat tcaaagaatg aaaagatttt agaagatatt
1860gtgttgacct taacgttatt tgaagataga gaaatgatta gaaaacgtct
agaaaattac 1920agtgatttat tgaccaaaga acaagtgaaa aagctggaaa
gacgtcatta tactggttgg 1980ggaagattat cagctgagtt aattcatggt
attcgcaata aagaaagcag aaaaacaatt 2040cttgattatc tcattgatga
tggcaatagc aatcggaact ttatgcaact gattaacgat 2100gatgctcttt
ctttcaaaga agagattgct aaggcacaag ttattggaga aacagacaat
2160ctaaatcaag ttgttagtga tattgctggc agccctgcta ttaaaaaagg
aattttacaa 2220agcttgaaga ttgttgatga gcttgtcaaa attatgggac
atcaacctga aaatatcgtc 2280gtggagatgg cgcgtgaaaa ccagtttacc
aatcagggac gacgaaattc acagcaacgt 2340ttgaaaggtt tgacagattc
tattaaagaa tttggaagtc aaattcttaa agaacatccg 2400gttgagaatt
cacagttaca aaatgataga ttgtttctat attatttaca aaacggcaga
2460gatatgtata ctggagaaga attggatatt gattatctaa gccagtatga
tatagaccat 2520attatcccgc aagcttttat aaaggataat tctattgata
atagagtatt gactagctca 2580aaggaaaatc gtggaaaatc ggatgatgta
ccaagtaaag atgttgttcg taaaatgaaa 2640tcctattgga gtaagctact
ttcggcaaag cttattacac aacgtaaatt tgataatttg 2700acaaaagctg
aacgaggtgg attgaccgac gatgataaag ctggattcat caagcgtcaa
2760ttagtagaaa cacgacaaat taccaaacat gtagcacgta ttctggacga
acgatttaat 2820acagaaacag atgaaaacaa caagaaaatt cgtcaagtaa
aaattgtgac cttgaaatca 2880aatcttgttt ccaatttccg taaagagttt
gaactctaca aagtgcgtga aattaatgac 2940tatcatcatg cacatgatgc
ctatctcaat gctgtaattg gaaaggcttt actaggtgtt 3000tacccacaat
tggaacctga atttgtttat ggtgattatc ctcattttca tggacataaa
3060gaaaataaag caactgctaa gaaatttttc tattcaaata ttatgaactt
ctttaaaaaa 3120gatgatgtcc gtactgataa aaatggtgaa attatctgga
aaaaagatga gcatatttct 3180aatattaaaa aagtgctttc ttatccacaa
gttaatattg ttaagaaagt agaggagcaa 3240acgggaggat tttctaaaga
atctatcttg ccgaaaggta attctgacaa gcttattcct 3300cgaaaaacga
agaaatttta ttgggatacc aagaaatatg gaggatttga tagcccgatt
3360gttgcttatt ctattttagt tattgctgat attgaaaaag gtaaatctaa
aaaattgaaa 3420acagtcaaag ccttagttgg tgtcactatt atggaaaaga
tgacttttga aagggatcca 3480gttgcttttc ttgagcgaaa aggctatcga
aatgttcaag aagaaaatat tataaagtta 3540ccaaaatata gtttatttaa
actagaaaac ggacgaaaaa ggctattggc aagtgctagg 3600gaacttcaaa
agggaaatga aatcgttttg ccaaatcatt taggaacctt gctttatcac
3660gctaaaaata ttcataaagt tgatgaacca aagcatttgg actatgttga
taaacataaa 3720gatgaattta aggagttgct agatgttgtg tcaaactttt
ctaaaaaata tactttagca 3780gaaggaaatt tagaaaaaat caaagaatta
tatgcacaaa ataatggtga agatcttaaa 3840gaattagcaa gttcatttat
caacttatta acatttactg ctataggagc accggctact 3900tttaaattct
ttgataaaaa tattgatcga aaacgatata cttcaactac tgaaattctc
3960aacgctaccc tcatccacca atccatcacc ggtctttatg aaacgcggat
tgatctcaat 4020aagttaggag gagactaa 403821720DNAArtificial
SequenceMprimer qADH-F 217caagtcgcgg ttttcaatca
2021821DNAArtificial SequencePrimer qADH-R 218tgaaggtgga agtcccaaca
a 2121919DNAArtificial Sequenceprobe ADH-VIC 219tgggaagcct
atctaccac 1922015DNAArtificial SequenceProbe wtEPSPS 220cggccattga
cagca 1522120DNAArtificial SequenceForward primer qEPSPS-F
221tcttggggaa tgctggaact 2022221DNAArtificial Sequencereverse
primer qEPSPSR 222caccagcagc agtaacagct g 2122317DNAArtificial
SequenceFAM-wtEPSPS R probe 223tgctgtcaat ggccgca
1722420DNAArtificial Sequenceforward primer qEPSPS-F 224tcttggggaa
tgctggaact 2022520DNAArtificial Sequencereverse primer q wtEPSPS RA
225ccaccagcag cagtaacagc 2022621DNAArtificial Sequenceorward primer
q epTIPS F 226ggaagtgcag ctcttcttgg g 2122719DNAArtificial
Sequencereverse primer q epTIPS R 227agctgctgtc aatgaccgc
1922815DNAArtificial SequenceTIPS probe 228aatgctggaa tcgca
1522923DNAZea maysMHP14Cas1 target site(1)..(23) 229gttaaatctg
acgtgaatct gtt 2323021DNAZea maysMHP14Cas3 target site(1)..(21)
230acaaacattg aagcgacata g 2123118DNAZea maysTS8Cas1 target
site(1)..(18) 231gtacgtaacg tgcagtac 1823220DNAZea maysTS8Cas2
target site(1)..(20) 232gctcatcagt gatcagctgg 2023317DNAZea
maysTS9Cas2 target site(1)..(17) 233ggctgtttgc ggcctcg
1723421DNAZea maysTS9Cas3 target site(1)..(21) 234gcctcgaggt
tgcacgcacg t 2123520DNAZea maysTS10Cas1 target site(1)..(20)
235gcctcgcctt cgctagttaa 2023618DNAZea maysTS10Cas3 target
site(1)..(18) 236gctcgtgttg gagataca 1823780DNAZea mays
237gttaaatctg acgtgaatct gtttggaatt gaaaaacaag tgcttccttt
catacaccac 60tatgtcgctt caatgtttgt 8023880DNAZea mays 238acaaacattg
aagcgacata gtggtgtatg aaaggaagca cttgtttttc aattccaaac 60agattcacgt
cagatttaac 8023966DNAZea mays 239ccagtactgc acgttacgta cgtacgaact
aatatactcc accagctgat cactgatgag 60ccgagc 6624066DNAZea mays
240gctcggctca tcagtgatca gctggtggag tatattagtt cgtacgtacg
taacgtgcag 60tactgg 6624135DNAZea mays 241ccgacgtgcg tgcaacctcg
aggccgcaaa cagcc 3524235DNAZea mays 242ggctgtttgc ggcctcgagg
ttgcacgcac gtcgg 3524368DNAZea mays 243gctcgtgttg gagatacagg
gacagcaagt acttggccct taactagcga aggcgaggcg 60gccatgga
6824468DNAZea mays 244tccatggccg cctcgccttc gctagttaag ggccaagtac
ttgctgtccc tgtatctcca 60acacgagc 682451108DNAArtificial
SequenceMHP14Cas-1 guideRNA cassette 245tgagagtaca atgatgaacc
tagattaatc aatgccaaag tctgaaaaat gcaccctcag 60tctatgatcc agaaaatcaa
gattgcttga ggccctgttc ggttgttccg gattagagcc 120ccggattaat
tcctagccgg attacttctc taatttatat agattttgat gagctggaat
180gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt
aatcgctgag 240ctaaattggc atgctgtcag agtgtcagta ttgcagcaag
gtagtgagat aaccggcatc 300atggtgccag tttgatggca ccattagggt
tagagatggt ggccatgggc gcatgtcctg 360gccaactttg tatgatatat
ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg 420gatttcttct
gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca
480aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg
acataatgat 540cccgcttaaa taagcaacct cgcttgtata gttccttgtg
ctctaacaca cgatgatgat 600aagtcgtaaa atagtggtgt ccaaagaatt
tccaggccca gttgtaaaag ctaaaatgct 660attcgaattt ctactagcag
taagtcgtgt ttagaaatta tttttttata tacctttttt 720ccttctatgt
acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa
780agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga
gagggccata 840agaaacatgg cccacggccc aatacgaagc accgcgacga
agcccaaaca gcagtccgta 900ggtggagcaa agcgctgggt aatacgcaaa
cgttttgtcc caccttgact aatcacaaga 960gtggagcgta ccttataaac
cgagccgcaa gcaccgaatt gttaaatctg acgtgaatct 1020gttgttttag
agctagaaat agcaagttaa aataaggcta gtccgttatc aacttgaaaa
1080agtggcaccg agtcggtgct tttttttt 11082461106DNAArtificial
SequenceMHP14Cas-3 gRNA cassette 246tgagagtaca atgatgaacc
tagattaatc aatgccaaag tctgaaaaat gcaccctcag 60tctatgatcc agaaaatcaa
gattgcttga ggccctgttc ggttgttccg gattagagcc 120ccggattaat
tcctagccgg attacttctc taatttatat agattttgat gagctggaat
180gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt
aatcgctgag 240ctaaattggc atgctgtcag agtgtcagta ttgcagcaag
gtagtgagat aaccggcatc 300atggtgccag tttgatggca ccattagggt
tagagatggt ggccatgggc gcatgtcctg 360gccaactttg tatgatatat
ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg 420gatttcttct
gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca
480aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg
acataatgat 540cccgcttaaa taagcaacct cgcttgtata gttccttgtg
ctctaacaca cgatgatgat 600aagtcgtaaa atagtggtgt ccaaagaatt
tccaggccca gttgtaaaag ctaaaatgct 660attcgaattt ctactagcag
taagtcgtgt ttagaaatta tttttttata tacctttttt 720ccttctatgt
acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa
780agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga
gagggccata 840agaaacatgg cccacggccc aatacgaagc accgcgacga
agcccaaaca gcagtccgta 900ggtggagcaa agcgctgggt aatacgcaaa
cgttttgtcc caccttgact aatcacaaga 960gtggagcgta ccttataaac
cgagccgcaa gcaccgaatt gcaaacattg aagcgacata 1020ggttttagag
ctagaaatag caagttaaaa taaggctagt ccgttatcaa cttgaaaaag
1080tggcaccgag tcggtgcttt tttttt 11062471103DNAArtificial
SequenceTS8Cas-1 guideRNA cassette 247tgagagtaca atgatgaacc
tagattaatc aatgccaaag tctgaaaaat gcaccctcag 60tctatgatcc agaaaatcaa
gattgcttga ggccctgttc ggttgttccg gattagagcc 120ccggattaat
tcctagccgg attacttctc taatttatat agattttgat gagctggaat
180gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt
aatcgctgag 240ctaaattggc atgctgtcag agtgtcagta ttgcagcaag
gtagtgagat aaccggcatc 300atggtgccag tttgatggca ccattagggt
tagagatggt ggccatgggc gcatgtcctg 360gccaactttg tatgatatat
ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg 420gatttcttct
gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca
480aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg
acataatgat 540cccgcttaaa taagcaacct cgcttgtata gttccttgtg
ctctaacaca cgatgatgat 600aagtcgtaaa atagtggtgt ccaaagaatt
tccaggccca gttgtaaaag ctaaaatgct 660attcgaattt ctactagcag
taagtcgtgt ttagaaatta tttttttata tacctttttt 720ccttctatgt
acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa
780agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga
gagggccata 840agaaacatgg cccacggccc aatacgaagc accgcgacga
agcccaaaca gcagtccgta 900ggtggagcaa agcgctgggt aatacgcaaa
cgttttgtcc caccttgact aatcacaaga 960gtggagcgta ccttataaac
cgagccgcaa gcaccgaatt gtacgtaacg tgcagtacgt 1020tttagagcta
gaaatagcaa gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg
1080caccgagtcg gtgctttttt ttt 11032481105DNAArtificial
SequenceTS8Cas-2 guideRNA cassette 248tgagagtaca atgatgaacc
tagattaatc aatgccaaag tctgaaaaat gcaccctcag 60tctatgatcc agaaaatcaa
gattgcttga ggccctgttc ggttgttccg gattagagcc 120ccggattaat
tcctagccgg attacttctc taatttatat agattttgat gagctggaat
180gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt
aatcgctgag 240ctaaattggc atgctgtcag agtgtcagta ttgcagcaag
gtagtgagat aaccggcatc 300atggtgccag tttgatggca ccattagggt
tagagatggt ggccatgggc gcatgtcctg 360gccaactttg tatgatatat
ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg 420gatttcttct
gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca
480aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg
acataatgat 540cccgcttaaa taagcaacct cgcttgtata gttccttgtg
ctctaacaca cgatgatgat 600aagtcgtaaa atagtggtgt ccaaagaatt
tccaggccca gttgtaaaag ctaaaatgct 660attcgaattt ctactagcag
taagtcgtgt ttagaaatta tttttttata tacctttttt 720ccttctatgt
acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa
780agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga
gagggccata 840agaaacatgg cccacggccc aatacgaagc accgcgacga
agcccaaaca gcagtccgta 900ggtggagcaa agcgctgggt aatacgcaaa
cgttttgtcc caccttgact aatcacaaga 960gtggagcgta ccttataaac
cgagccgcaa gcaccgaatt gctcatcagt gatcagctgg 1020gttttagagc
tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt
1080ggcaccgagt cggtgctttt ttttt 11052491102DNAArtificial
SequenceTS9Cas-2 guideRNA cassette 249tgagagtaca atgatgaacc
tagattaatc aatgccaaag tctgaaaaat gcaccctcag 60tctatgatcc agaaaatcaa
gattgcttga ggccctgttc ggttgttccg gattagagcc 120ccggattaat
tcctagccgg attacttctc taatttatat agattttgat gagctggaat
180gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt
aatcgctgag 240ctaaattggc atgctgtcag agtgtcagta ttgcagcaag
gtagtgagat aaccggcatc 300atggtgccag tttgatggca ccattagggt
tagagatggt ggccatgggc gcatgtcctg 360gccaactttg tatgatatat
ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg 420gatttcttct
gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca
480aagatctggc tgtgtttcca gctgtttttg
ttagccccat cgaatccttg acataatgat 540cccgcttaaa taagcaacct
cgcttgtata gttccttgtg ctctaacaca cgatgatgat 600aagtcgtaaa
atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct
660attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata
tacctttttt 720ccttctatgt acagtaggac acagtgtcag cgccgcgttg
acggagaata tttgcaaaaa 780agtaaaagag aaagtcatag cggcgtatgt
gccaaaaact tcgtcacaga gagggccata 840agaaacatgg cccacggccc
aatacgaagc accgcgacga agcccaaaca gcagtccgta 900ggtggagcaa
agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga
960gtggagcgta ccttataaac cgagccgcaa gcaccgaatt ggctgtttgc
ggcctcggtt 1020ttagagctag aaatagcaag ttaaaataag gctagtccgt
tatcaacttg aaaaagtggc 1080accgagtcgg tgcttttttt tt
11022501106DNAArtificial SequenceTS9Cas-3 guideRNA cassette
250tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat
gcaccctcag 60tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg
gattagagcc 120ccggattaat tcctagccgg attacttctc taatttatat
agattttgat gagctggaat 180gaatcctggc ttattccggt acaaccgaac
aggccctgaa ggataccagt aatcgctgag 240ctaaattggc atgctgtcag
agtgtcagta ttgcagcaag gtagtgagat aaccggcatc 300atggtgccag
tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg
360gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat
tgtaaaaagg 420gatttcttct gtttgttagc gcatgtacaa ggaatgcaag
ttttgagcga gggggcatca 480aagatctggc tgtgtttcca gctgtttttg
ttagccccat cgaatccttg acataatgat 540cccgcttaaa taagcaacct
cgcttgtata gttccttgtg ctctaacaca cgatgatgat 600aagtcgtaaa
atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct
660attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata
tacctttttt 720ccttctatgt acagtaggac acagtgtcag cgccgcgttg
acggagaata tttgcaaaaa 780agtaaaagag aaagtcatag cggcgtatgt
gccaaaaact tcgtcacaga gagggccata 840agaaacatgg cccacggccc
aatacgaagc accgcgacga agcccaaaca gcagtccgta 900ggtggagcaa
agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga
960gtggagcgta ccttataaac cgagccgcaa gcaccgaatt gcctcgaggt
tgcacgcacg 1020tgttttagag ctagaaatag caagttaaaa taaggctagt
ccgttatcaa cttgaaaaag 1080tggcaccgag tcggtgcttt tttttt
11062511105DNAArtificial SequenceTS10Cas-1 guideRNA cassette
251tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat
gcaccctcag 60tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg
gattagagcc 120ccggattaat tcctagccgg attacttctc taatttatat
agattttgat gagctggaat 180gaatcctggc ttattccggt acaaccgaac
aggccctgaa ggataccagt aatcgctgag 240ctaaattggc atgctgtcag
agtgtcagta ttgcagcaag gtagtgagat aaccggcatc 300atggtgccag
tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg
360gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat
tgtaaaaagg 420gatttcttct gtttgttagc gcatgtacaa ggaatgcaag
ttttgagcga gggggcatca 480aagatctggc tgtgtttcca gctgtttttg
ttagccccat cgaatccttg acataatgat 540cccgcttaaa taagcaacct
cgcttgtata gttccttgtg ctctaacaca cgatgatgat 600aagtcgtaaa
atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct
660attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata
tacctttttt 720ccttctatgt acagtaggac acagtgtcag cgccgcgttg
acggagaata tttgcaaaaa 780agtaaaagag aaagtcatag cggcgtatgt
gccaaaaact tcgtcacaga gagggccata 840agaaacatgg cccacggccc
aatacgaagc accgcgacga agcccaaaca gcagtccgta 900ggtggagcaa
agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga
960gtggagcgta ccttataaac cgagccgcaa gcaccgaatt gcctcgcctt
cgctagttaa 1020gttttagagc tagaaatagc aagttaaaat aaggctagtc
cgttatcaac ttgaaaaagt 1080ggcaccgagt cggtgctttt ttttt
11052521103DNAArtificial SequenceTSCas-3 guideRNA cassette
252tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat
gcaccctcag 60tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg
gattagagcc 120ccggattaat tcctagccgg attacttctc taatttatat
agattttgat gagctggaat 180gaatcctggc ttattccggt acaaccgaac
aggccctgaa ggataccagt aatcgctgag 240ctaaattggc atgctgtcag
agtgtcagta ttgcagcaag gtagtgagat aaccggcatc 300atggtgccag
tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg
360gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat
tgtaaaaagg 420gatttcttct gtttgttagc gcatgtacaa ggaatgcaag
ttttgagcga gggggcatca 480aagatctggc tgtgtttcca gctgtttttg
ttagccccat cgaatccttg acataatgat 540cccgcttaaa taagcaacct
cgcttgtata gttccttgtg ctctaacaca cgatgatgat 600aagtcgtaaa
atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct
660attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata
tacctttttt 720ccttctatgt acagtaggac acagtgtcag cgccgcgttg
acggagaata tttgcaaaaa 780agtaaaagag aaagtcatag cggcgtatgt
gccaaaaact tcgtcacaga gagggccata 840agaaacatgg cccacggccc
aatacgaagc accgcgacga agcccaaaca gcagtccgta 900ggtggagcaa
agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga
960gtggagcgta ccttataaac cgagccgcaa gcaccgaatt gctcgtgttg
gagatacagt 1020tttagagcta gaaatagcaa gttaaaataa ggctagtccg
ttatcaactt gaaaaagtgg 1080caccgagtcg gtgctttttt ttt
11032534928DNAArtificial SequenceMHP14Cas1 donor 253gccatgtcat
cttgtagtta gggcttggag ctagtcgacc gttggaggct ttgtcctcat 60gcggcaccgg
acagtctggt gctacaccgg acagtccggt gcccctctga ccatctgctc
120tgacatctga attgcactgt tcactttgca gagtcgacca ttgcgtgcag
gtagccattg 180ctccgctggt gcaccggaca gtccagtggc acaccggaca
gtccgatgaa ttatagcgga 240gctgcgcctg ggaaacccga agctgaggag
tttgagctga ttcaccctgg tgcaccggac 300actgtccggt ggcacactgg
acagtccggt gcgccggacc agggcacact tcggtttcct 360ttttgctcct
ttcttttgaa gcctaacttg ttcttttgat tggtttgtgt tgaaccttta
420gcacctgtag aatgtatgat ctagagcaaa ctagttagtc caattatttg
tgttgggcaa 480ttcaaccacc aaaaacattt aggaaaatgt ttgatcttat
ttccctttca tattctctta 540ttgctagttg tcggggtgaa gttgagctct
tgcttaggtt ttaattagtg ttgattttta 600gaaaaaccca attcaccccc
ctcttgggca tcgtgatcct tttagcaaca aaatgtgcac 660acatcaaaac
aagcgcttct accatatgta gttgttgcac aataatggtc ctccttagga
720tttgcaaccg tttaacaata gctatgtgac cacagattta tgtcggatgc
acgaaaattg 780taggatttta catttcttta ccttggttca caaacattga
agcgacatag tggtgtatga 840aaggaagcac ttgtttttca attccaaacc
gcggtaccat ttaaatctta agcctaggat 900aacttcgtat agcatacatt
atacgaagtt atggcgccgc tagcctgcag tgcagcgtga 960cccggtcgtg
cccctctcta gagataatga gcattgcatg tctaagttat aaaaaattac
1020cacatatttt ttttgtcaca cttgtttgaa gtgcagttta tctatcttta
tacatatatt 1080taaactttac tctacgaata atataatcta tagtactaca
ataatatcag tgttttagag 1140aatcatataa atgaacagtt agacatggtc
taaaggacaa ttgagtattt tgacaacagg 1200actctacagt tttatctttt
tagtgtgcat gtgttctcct ttttttttgc aaatagcttc 1260acctatataa
tacttcatcc attttattag tacatccatt tagggtttag ggttaatggt
1320ttttatagac taattttttt agtacatcta ttttattcta ttttagcctc
taaattaaga 1380aaactaaaac tctattttag tttttttatt taataattta
gatataaaat agaataaaat 1440aaagtgacta aaaattaaac aaataccctt
taagaaatta aaaaaactaa ggaaacattt 1500ttcttgtttc gagtagataa
tgccagcctg ttaaacgccg tcgacgagtc taacggacac 1560caaccagcga
accagcagcg tcgcgtcggg ccaagcgaag cagacggcac ggcatctctg
1620tcgctgcctc tggacccctc tcgagagttc cgctccaccg ttggacttgc
tccgctgtcg 1680gcatccagaa attgcgtggc ggagcggcag acgtgagccg
gcacggcagg cggcctcctc 1740ctcctctcac ggcaccggca gctacggggg
attcctttcc caccgctcct tcgctttccc 1800ttcctcgccc gccgtaataa
atagacaccc cctccacacc ctctttcccc aacctcgtgt 1860tgttcggagc
gcacacacac acaaccagat ctcccccaaa tccacccgtc ggcacctccg
1920cttcaaggta cgccgctcgt cctccccccc ccccctctct accttctcta
gatcggcgtt 1980ccggtccatg catggttagg gcccggtagt tctacttctg
ttcatgtttg tgttagatcc 2040gtgtttgtgt tagatccgtg ctgctagcgt
tcgtacacgg atgcgacctg tacgtcagac 2100acgttctgat tgctaacttg
ccagtgtttc tctttgggga atcctgggat ggctctagcc 2160gttccgcaga
cgggatcgat ttcatgattt tttttgtttc gttgcatagg gtttggtttg
2220cccttttcct ttatttcaat atatgccgtg cacttgtttg tcgggtcatc
ttttcatgct 2280tttttttgtc ttggttgtga tgatgtggtc tggttgggcg
gtcgttctag atcggagtag 2340aattctgttt caaactacct ggtggattta
ttaattttgg atctgtatgt gtgtgccata 2400catattcata gttacgaatt
gaagatgatg gatggaaata tcgatctagg ataggtatac 2460atgttgatgc
gggttttact gatgcatata cagagatgct ttttgttcgc ttggttgtga
2520tgatgtggtg tggttgggcg gtcgttcatt cgttctagat cggagtagaa
tactgtttca 2580aactacctgg tgtatttatt aattttggaa ctgtatgtgt
gtgtcataca tcttcatagt 2640tacgagttta agatggatgg aaatatcgat
ctaggatagg tatacatgtt gatgtgggtt 2700ttactgatgc atatacatga
tggcatatgc agcatctatt catatgctct aaccttgagt 2760acctatctat
tataataaac aagtatgttt tataattatt ttgatcttga tatacttgga
2820tgatggcata tgcagcagct atatgtggat ttttttagcc ctgccttcat
acgctattta 2880tttgcttggt actgtttctt ttgtcgatgc tcaccctgtt
gtttggtgtt acttctgcag 2940gtcgactcta gaggatcaat tcgctagcga
agttcctatt ccgaagttcc tattctctag 3000aaagtatagg aacttcagat
ccaccgggat ccccgatcat gcaaaaactc attaactcag 3060tgcaaaacta
tgcctggggc agcaaaacgg cgttgactga actttatggt atggaaaatc
3120cgtccagcca gccgatggcc gagctgtgga tgggcgcaca tccgaaaagc
agttcacgag 3180tgcagaatgc cgccggagat atcgtttcac tgcgtgatgt
gattgagagt gataaatcga 3240ctctgctcgg agaggccgtt gccaaacgct
ttggcgaact gcctttcctg ttcaaagtat 3300tatgcgcagc acagccactc
tccattcagg ttcatccaaa caaacacaat tctgaaatcg 3360gttttgccaa
agaaaatgcc gcaggtatcc cgatggatgc cgccgagcgt aactataaag
3420atcctaacca caagccggag ctggtttttg cgctgacgcc tttccttgcg
atgaacgcgt 3480ttcgtgaatt ttccgagatt gtctccctac tccagccggt
cgcaggtgca catccggcga 3540ttgctcactt tttacaacag cctgatgccg
aacgtttaag cgaactgttc gccagcctgt 3600tgaatatgca gggtgaagaa
aaatcccgcg cgctggcgat tttaaaatcg gccctcgata 3660gccagcaggg
tgaaccgtgg caaacgattc gtttaatttc tgaattttac ccggaagaca
3720gcggtctgtt ctccccgcta ttgctgaatg tggtgaaatt gaaccctggc
gaagcgatgt 3780tcctgttcgc tgaaacaccg cacgcttacc tgcaaggcgt
ggcgctggaa gtgatggcaa 3840actccgataa cgtgctgcgt gcgggtctga
cgcctaaata cattgatatt ccggaactgg 3900ttgccaatgt gaaattcgaa
gccaaaccgg ctaaccagtt gttgacccag ccggtgaaac 3960aaggtgcaga
actggacttc ccgattccag tggatgattt tgccttctcg ctgcatgacc
4020ttagtgataa agaaaccacc attagccagc agagtgccgc cattttgttc
tgcgtcgaag 4080gcgatgcaac gttgtggaaa ggttctcagc agttacagct
taaaccgggt gaatcagcgt 4140ttattgccgc caacgaatca ccggtgactg
tcaaaggcca cggccgttta gcgcgtgttt 4200acaacaagct gtaagagctt
actgaaaaaa ttaacatctc ttgctaagct gggggtggaa 4260cctagacttg
tccatcttct ggattggcca acttaattaa tgtatgaaat aaaaggatgc
4320acacatagtg acatgctaat cactataatg tgggcatcaa agttgtgtgt
tatgtgtaat 4380tactagttat ctgaataaaa gagaaagaga tcatccatat
ttcttatcct aaatgaatgt 4440cacgtgtctt tataattctt tgatgaacca
gatgcatttc attaaccaaa tccatataca 4500tataaatatt aatcatatat
aattaatatc aattgggtta gcaaaacaaa tctagtctag 4560gtgtgttttg
cgaatgcggc cctagcgtat acgaagttcc tattccgaag ttcctattct
4620ccagaaagta taggaacttc tgtacacctg agctgattcc gatgacttcg
taggttccta 4680gctcaagccg ctcgtgtcca agcgtcactt acgattagct
aatgattacg gcatctagga 4740ccgactagct aactaactag taccgaggcc
ggccccgcgg gagctcggcg cgccagattc 4800acgtcagatt taaccaaaac
tatattatga ggtacacata ttacaatcca aaatgaatta 4860tctagttctc
gagttgtaca cagtttatca cgtgttttac acattccaac cctaaactcc 4920aaccgtgg
49282544570DNAArtificial SequenceMHP14Cas3 donor 254acacttcggt
ttcctttttg ctcctttctt ttgaagccta acttgttctt ttgattggtt 60tgtgttgaac
ctttagcacc tgtagaatgt atgatctaga gcaaactagt tagtccaatt
120atttgtgttg ggcaattcaa ccaccaaaaa catttaggaa aatgtttgat
cttatttccc 180tttcatattc tcttattgct agttgtcggg gtgaagttga
gctcttgctt aggttttaat 240tagtgttgat ttttagaaaa acccaattca
cccccctctt gggcatcgtg atccttttag 300caacaaaatg tgcacacatc
aaaacaagcg cttctaccat atgtagttgt tgcacaataa 360tggtcctcct
taggatttgc aaccgtttaa caatagctat gtgaccacag atttatgtcg
420gatgcacgaa aattgtagga ttttacattt ctttaccttg gttcacaaac
attgaagcga 480caggtaccat ttaaatctta agcctaggat aacttcgtat
agcatacatt atacgaagtt 540atggcgccgc tagcctgcag tgcagcgtga
cccggtcgtg cccctctcta gagataatga 600gcattgcatg tctaagttat
aaaaaattac cacatatttt ttttgtcaca cttgtttgaa 660gtgcagttta
tctatcttta tacatatatt taaactttac tctacgaata atataatcta
720tagtactaca ataatatcag tgttttagag aatcatataa atgaacagtt
agacatggtc 780taaaggacaa ttgagtattt tgacaacagg actctacagt
tttatctttt tagtgtgcat 840gtgttctcct ttttttttgc aaatagcttc
acctatataa tacttcatcc attttattag 900tacatccatt tagggtttag
ggttaatggt ttttatagac taattttttt agtacatcta 960ttttattcta
ttttagcctc taaattaaga aaactaaaac tctattttag tttttttatt
1020taataattta gatataaaat agaataaaat aaagtgacta aaaattaaac
aaataccctt 1080taagaaatta aaaaaactaa ggaaacattt ttcttgtttc
gagtagataa tgccagcctg 1140ttaaacgccg tcgacgagtc taacggacac
caaccagcga accagcagcg tcgcgtcggg 1200ccaagcgaag cagacggcac
ggcatctctg tcgctgcctc tggacccctc tcgagagttc 1260cgctccaccg
ttggacttgc tccgctgtcg gcatccagaa attgcgtggc ggagcggcag
1320acgtgagccg gcacggcagg cggcctcctc ctcctctcac ggcaccggca
gctacggggg 1380attcctttcc caccgctcct tcgctttccc ttcctcgccc
gccgtaataa atagacaccc 1440cctccacacc ctctttcccc aacctcgtgt
tgttcggagc gcacacacac acaaccagat 1500ctcccccaaa tccacccgtc
ggcacctccg cttcaaggta cgccgctcgt cctccccccc 1560ccccctctct
accttctcta gatcggcgtt ccggtccatg catggttagg gcccggtagt
1620tctacttctg ttcatgtttg tgttagatcc gtgtttgtgt tagatccgtg
ctgctagcgt 1680tcgtacacgg atgcgacctg tacgtcagac acgttctgat
tgctaacttg ccagtgtttc 1740tctttgggga atcctgggat ggctctagcc
gttccgcaga cgggatcgat ttcatgattt 1800tttttgtttc gttgcatagg
gtttggtttg cccttttcct ttatttcaat atatgccgtg 1860cacttgtttg
tcgggtcatc ttttcatgct tttttttgtc ttggttgtga tgatgtggtc
1920tggttgggcg gtcgttctag atcggagtag aattctgttt caaactacct
ggtggattta 1980ttaattttgg atctgtatgt gtgtgccata catattcata
gttacgaatt gaagatgatg 2040gatggaaata tcgatctagg ataggtatac
atgttgatgc gggttttact gatgcatata 2100cagagatgct ttttgttcgc
ttggttgtga tgatgtggtg tggttgggcg gtcgttcatt 2160cgttctagat
cggagtagaa tactgtttca aactacctgg tgtatttatt aattttggaa
2220ctgtatgtgt gtgtcataca tcttcatagt tacgagttta agatggatgg
aaatatcgat 2280ctaggatagg tatacatgtt gatgtgggtt ttactgatgc
atatacatga tggcatatgc 2340agcatctatt catatgctct aaccttgagt
acctatctat tataataaac aagtatgttt 2400tataattatt ttgatcttga
tatacttgga tgatggcata tgcagcagct atatgtggat 2460ttttttagcc
ctgccttcat acgctattta tttgcttggt actgtttctt ttgtcgatgc
2520tcaccctgtt gtttggtgtt acttctgcag gtcgactcta gaggatcaat
tcgctagcga 2580agttcctatt ccgaagttcc tattctctag aaagtatagg
aacttcagat ccaccgggat 2640ccccgatcat gcaaaaactc attaactcag
tgcaaaacta tgcctggggc agcaaaacgg 2700cgttgactga actttatggt
atggaaaatc cgtccagcca gccgatggcc gagctgtgga 2760tgggcgcaca
tccgaaaagc agttcacgag tgcagaatgc cgccggagat atcgtttcac
2820tgcgtgatgt gattgagagt gataaatcga ctctgctcgg agaggccgtt
gccaaacgct 2880ttggcgaact gcctttcctg ttcaaagtat tatgcgcagc
acagccactc tccattcagg 2940ttcatccaaa caaacacaat tctgaaatcg
gttttgccaa agaaaatgcc gcaggtatcc 3000cgatggatgc cgccgagcgt
aactataaag atcctaacca caagccggag ctggtttttg 3060cgctgacgcc
tttccttgcg atgaacgcgt ttcgtgaatt ttccgagatt gtctccctac
3120tccagccggt cgcaggtgca catccggcga ttgctcactt tttacaacag
cctgatgccg 3180aacgtttaag cgaactgttc gccagcctgt tgaatatgca
gggtgaagaa aaatcccgcg 3240cgctggcgat tttaaaatcg gccctcgata
gccagcaggg tgaaccgtgg caaacgattc 3300gtttaatttc tgaattttac
ccggaagaca gcggtctgtt ctccccgcta ttgctgaatg 3360tggtgaaatt
gaaccctggc gaagcgatgt tcctgttcgc tgaaacaccg cacgcttacc
3420tgcaaggcgt ggcgctggaa gtgatggcaa actccgataa cgtgctgcgt
gcgggtctga 3480cgcctaaata cattgatatt ccggaactgg ttgccaatgt
gaaattcgaa gccaaaccgg 3540ctaaccagtt gttgacccag ccggtgaaac
aaggtgcaga actggacttc ccgattccag 3600tggatgattt tgccttctcg
ctgcatgacc ttagtgataa agaaaccacc attagccagc 3660agagtgccgc
cattttgttc tgcgtcgaag gcgatgcaac gttgtggaaa ggttctcagc
3720agttacagct taaaccgggt gaatcagcgt ttattgccgc caacgaatca
ccggtgactg 3780tcaaaggcca cggccgttta gcgcgtgttt acaacaagct
gtaagagctt actgaaaaaa 3840ttaacatctc ttgctaagct gggggtggaa
cctagacttg tccatcttct ggattggcca 3900acttaattaa tgtatgaaat
aaaaggatgc acacatagtg acatgctaat cactataatg 3960tgggcatcaa
agttgtgtgt tatgtgtaat tactagttat ctgaataaaa gagaaagaga
4020tcatccatat ttcttatcct aaatgaatgt cacgtgtctt tataattctt
tgatgaacca 4080gatgcatttc attaaccaaa tccatataca tataaatatt
aatcatatat aattaatatc 4140aattgggtta gcaaaacaaa tctagtctag
gtgtgttttg cgaatgcggc cctagcgtat 4200acgaagttcc tattccgaag
ttcctattct ccagaaagta taggaacttc tgtacacctg 4260agctgattcc
gatgacttcg taggttccta gctcaagccg ctcgtgtcca agcgtcactt
4320acgattagct aatgattacg gcatctagga ccgactagct aactaactag
taccgaggcc 4380ggccccgcgg gagctcggcg cgcctagtgg tgtatgaaag
gaagcacttg tttttcaatt 4440ccaaacagat tcacgtcaga tttaaccaaa
actatattat gaggtacaca tattacaatc 4500caaaatgaat tatctagttc
tcgagttgta cacagtttat cacgtgtttt acacattcca 4560accctaaact
45702555091DNAArtificial SequenceTS8Cas-1 donor 255cacacatgac
tgcctgagaa tctgctgccg ttgcctctca tattatattc gatcccctga 60ctaaaaaaac
tcggggccgg ctaatacgta ctgtacgtac gcagaattta cggtccagca
120cgggcatgcc gcgcgggctg actttgctcc actgactcga tcatgtgcgg
attccatcgc 180ggcgtagcgt agccaaccgc aacgcaaacc gacttcatct
ttttttttta ttatgaacaa 240aaggagatcg agagaaacgt gaacggtaaa
taatatatct gatcccatgc atgcacgctg 300cctgggtcga tctcgctctc
gctccgccca gacgaacatg catgctggtc aggctcaacg 360ctcaggcggg
caagctgtgg gaggacatgg gatgggagag gaggacacat gcatgctggc
420cagtcaggca ctgtgctggc acatgaggta gggatagggg ggccctcggc
cagtgtccag 480gccgcatgca tgcatgcccc ccctgctgct cgaccgaaca
acgttggatg cctggattga 540tgcaacagtt tggacggacg gaccatacgt
tatgtaccag taggtaccat ttaaatctta 600agcctaggat aacttcgtat
agcatacatt atacgaagtt atggcgccgc tagcctgcag 660tgcagcgtga
cccggtcgtg cccctctcta gagataatga gcattgcatg tctaagttat
720aaaaaattac cacatatttt ttttgtcaca cttgtttgaa gtgcagttta
tctatcttta 780tacatatatt taaactttac tctacgaata atataatcta
tagtactaca ataatatcag 840tgttttagag aatcatataa atgaacagtt
agacatggtc taaaggacaa ttgagtattt 900tgacaacagg actctacagt
tttatctttt tagtgtgcat gtgttctcct ttttttttgc 960aaatagcttc
acctatataa tacttcatcc attttattag tacatccatt tagggtttag
1020ggttaatggt ttttatagac taattttttt agtacatcta ttttattcta
ttttagcctc 1080taaattaaga aaactaaaac tctattttag tttttttatt
taataattta gatataaaat 1140agaataaaat aaagtgacta aaaattaaac
aaataccctt taagaaatta aaaaaactaa 1200ggaaacattt ttcttgtttc
gagtagataa tgccagcctg ttaaacgccg tcgacgagtc 1260taacggacac
caaccagcga accagcagcg tcgcgtcggg ccaagcgaag cagacggcac
1320ggcatctctg tcgctgcctc tggacccctc tcgagagttc cgctccaccg
ttggacttgc 1380tccgctgtcg gcatccagaa attgcgtggc ggagcggcag
acgtgagccg gcacggcagg 1440cggcctcctc ctcctctcac ggcaccggca
gctacggggg attcctttcc caccgctcct 1500tcgctttccc ttcctcgccc
gccgtaataa atagacaccc cctccacacc ctctttcccc 1560aacctcgtgt
tgttcggagc gcacacacac acaaccagat ctcccccaaa tccacccgtc
1620ggcacctccg cttcaaggta cgccgctcgt cctccccccc ccccctctct
accttctcta 1680gatcggcgtt ccggtccatg catggttagg gcccggtagt
tctacttctg ttcatgtttg 1740tgttagatcc gtgtttgtgt tagatccgtg
ctgctagcgt tcgtacacgg atgcgacctg 1800tacgtcagac acgttctgat
tgctaacttg ccagtgtttc tctttgggga atcctgggat 1860ggctctagcc
gttccgcaga cgggatcgat ttcatgattt tttttgtttc gttgcatagg
1920gtttggtttg cccttttcct ttatttcaat atatgccgtg cacttgtttg
tcgggtcatc 1980ttttcatgct tttttttgtc ttggttgtga tgatgtggtc
tggttgggcg gtcgttctag 2040atcggagtag aattctgttt caaactacct
ggtggattta ttaattttgg atctgtatgt 2100gtgtgccata catattcata
gttacgaatt gaagatgatg gatggaaata tcgatctagg 2160ataggtatac
atgttgatgc gggttttact gatgcatata cagagatgct ttttgttcgc
2220ttggttgtga tgatgtggtg tggttgggcg gtcgttcatt cgttctagat
cggagtagaa 2280tactgtttca aactacctgg tgtatttatt aattttggaa
ctgtatgtgt gtgtcataca 2340tcttcatagt tacgagttta agatggatgg
aaatatcgat ctaggatagg tatacatgtt 2400gatgtgggtt ttactgatgc
atatacatga tggcatatgc agcatctatt catatgctct 2460aaccttgagt
acctatctat tataataaac aagtatgttt tataattatt ttgatcttga
2520tatacttgga tgatggcata tgcagcagct atatgtggat ttttttagcc
ctgccttcat 2580acgctattta tttgcttggt actgtttctt ttgtcgatgc
tcaccctgtt gtttggtgtt 2640acttctgcag gtcgactcta gaggatcaat
tcgctagcga agttcctatt ccgaagttcc 2700tattctctag aaagtatagg
aacttcagat ccaccgggat ccccgatcat gcaaaaactc 2760attaactcag
tgcaaaacta tgcctggggc agcaaaacgg cgttgactga actttatggt
2820atggaaaatc cgtccagcca gccgatggcc gagctgtgga tgggcgcaca
tccgaaaagc 2880agttcacgag tgcagaatgc cgccggagat atcgtttcac
tgcgtgatgt gattgagagt 2940gataaatcga ctctgctcgg agaggccgtt
gccaaacgct ttggcgaact gcctttcctg 3000ttcaaagtat tatgcgcagc
acagccactc tccattcagg ttcatccaaa caaacacaat 3060tctgaaatcg
gttttgccaa agaaaatgcc gcaggtatcc cgatggatgc cgccgagcgt
3120aactataaag atcctaacca caagccggag ctggtttttg cgctgacgcc
tttccttgcg 3180atgaacgcgt ttcgtgaatt ttccgagatt gtctccctac
tccagccggt cgcaggtgca 3240catccggcga ttgctcactt tttacaacag
cctgatgccg aacgtttaag cgaactgttc 3300gccagcctgt tgaatatgca
gggtgaagaa aaatcccgcg cgctggcgat tttaaaatcg 3360gccctcgata
gccagcaggg tgaaccgtgg caaacgattc gtttaatttc tgaattttac
3420ccggaagaca gcggtctgtt ctccccgcta ttgctgaatg tggtgaaatt
gaaccctggc 3480gaagcgatgt tcctgttcgc tgaaacaccg cacgcttacc
tgcaaggcgt ggcgctggaa 3540gtgatggcaa actccgataa cgtgctgcgt
gcgggtctga cgcctaaata cattgatatt 3600ccggaactgg ttgccaatgt
gaaattcgaa gccaaaccgg ctaaccagtt gttgacccag 3660ccggtgaaac
aaggtgcaga actggacttc ccgattccag tggatgattt tgccttctcg
3720ctgcatgacc ttagtgataa agaaaccacc attagccagc agagtgccgc
cattttgttc 3780tgcgtcgaag gcgatgcaac gttgtggaaa ggttctcagc
agttacagct taaaccgggt 3840gaatcagcgt ttattgccgc caacgaatca
ccggtgactg tcaaaggcca cggccgttta 3900gcgcgtgttt acaacaagct
gtaagagctt actgaaaaaa ttaacatctc ttgctaagct 3960gggggtggaa
cctagacttg tccatcttct ggattggcca acttaattaa tgtatgaaat
4020aaaaggatgc acacatagtg acatgctaat cactataatg tgggcatcaa
agttgtgtgt 4080tatgtgtaat tactagttat ctgaataaaa gagaaagaga
tcatccatat ttcttatcct 4140aaatgaatgt cacgtgtctt tataattctt
tgatgaacca gatgcatttc attaaccaaa 4200tccatataca tataaatatt
aatcatatat aattaatatc aattgggtta gcaaaacaaa 4260tctagtctag
gtgtgttttg cgaatgcggc cctagcgtat acgaagttcc tattccgaag
4320ttcctattct ccagaaagta taggaacttc tgtacacctg agctgattcc
gatgacttcg 4380taggttccta gctcaagccg ctcgtgtcca agcgtcactt
acgattagct aatgattacg 4440gcatctagga ccgactagct aactaactag
taccgaggcc ggccccgcgg actgcacgtt 4500acgtacgtac gaactaatat
actccaccag ctgatcactg atgagccgag ccgccatgca 4560ttgtaattta
taacatgtgc ggctgtacgc ttccatctca aatacctttt tatatatata
4620ttgtacttta tagtctacga cataatctgc catggtaatt tataagatgt
gctttattgc 4680tcgttgttct gttctcatct gtgtccatgg catggcatgg
atacaaaatg tatgtatggc 4740cacgcatcca atctgtgacg ttgtcaaggc
agaggtccaa ccgtccaaga ccctcttgtg 4800ccgccctgta cttgcagtca
gtgacgttgt gagaaaaagc tgtgggtggt ctccgcagag 4860cgcgcgggcc
acgagaggga gccccatctc tcggccgagg ggtacggggg ctccagacac
4920ggtcctttgg tttcttctgc ctgtagcgag cggccccgcc ccccaccgcg
ctgctagcct 4980agccgatgct gatccatcca ccacccacaa gggattgttc
cacgacttgt ggacctgacc 5040atgacgtgac ttcacgccat gtacgctcag
ccgctcacta gctttttttt c 50912565237DNAArtificial SequenceTS8Cas-2
donor 256tctctttcag ggcttgttcg tttacgttgg attgcacccg gaatcgttac
agctaatcaa 60agtttatata aattagagaa gcaaccggat aggaatcgtt ccgacccacc
aattcgacac 120aaacgaacaa ggcctcaatc cttctcaatc cacctccaac
ccaataagct cttggaggcg 180gcggcgggag agcagccaca cacatgactg
cctgagaatc tgctgccgtt gcctctcata 240ttatattcga tcccctgact
aaaaaaactc ggggccggct aatacgtact gtacgtacgc 300agaatttacg
gtccagcacg ggcatgccgc gcgggctgac tttgctccac tgactcgatc
360atgtgcggat tccatcgcgg cgtagcgtag ccaaccgcaa cgcaaaccga
cttcatcttt 420tttttttatt atgaacaaaa ggagatcgag agaaacgtga
acggtaaata atatatctga 480tcccatgcat gcacgctgcc tgggtcgatc
tcgctctcgc tccgcccaga cgaacatgca 540tgctggtcag gctcaacgct
caggcgggca agctgtggga ggacatggga tgggagagga 600ggacacatgc
atgctggcca gtcaggcact gtgctggcac atgaggtagg gatagggggg
660ccctcggcca gtgtccaggc cgcatgcatg catgcccccc ctgctgctcg
accgaacaac 720gttggatgcc tggattgatg caacagtttg gacggacgga
ccatacgtta tgtaccagta 780ctgcacgtta cgtacgtacg aactaatata
ctccaccagg taccatttaa atcttaagcc 840taggataact tcgtatagca
tacattatac gaagttatgg cgccgctagc ctgcagtgca 900gcgtgacccg
gtcgtgcccc tctctagaga taatgagcat tgcatgtcta agttataaaa
960aattaccaca tatttttttt gtcacacttg tttgaagtgc agtttatcta
tctttataca 1020tatatttaaa ctttactcta cgaataatat aatctatagt
actacaataa tatcagtgtt 1080ttagagaatc atataaatga acagttagac
atggtctaaa ggacaattga gtattttgac 1140aacaggactc tacagtttta
tctttttagt gtgcatgtgt tctccttttt ttttgcaaat 1200agcttcacct
atataatact tcatccattt tattagtaca tccatttagg gtttagggtt
1260aatggttttt atagactaat ttttttagta catctatttt attctatttt
agcctctaaa 1320ttaagaaaac taaaactcta ttttagtttt tttatttaat
aatttagata taaaatagaa 1380taaaataaag tgactaaaaa ttaaacaaat
accctttaag aaattaaaaa aactaaggaa 1440acatttttct tgtttcgagt
agataatgcc agcctgttaa acgccgtcga cgagtctaac 1500ggacaccaac
cagcgaacca gcagcgtcgc gtcgggccaa gcgaagcaga cggcacggca
1560tctctgtcgc tgcctctgga cccctctcga gagttccgct ccaccgttgg
acttgctccg 1620ctgtcggcat ccagaaattg cgtggcggag cggcagacgt
gagccggcac ggcaggcggc 1680ctcctcctcc tctcacggca ccggcagcta
cgggggattc ctttcccacc gctccttcgc 1740tttcccttcc tcgcccgccg
taataaatag acaccccctc cacaccctct ttccccaacc 1800tcgtgttgtt
cggagcgcac acacacacaa ccagatctcc cccaaatcca cccgtcggca
1860cctccgcttc aaggtacgcc gctcgtcctc cccccccccc ctctctacct
tctctagatc 1920ggcgttccgg tccatgcatg gttagggccc ggtagttcta
cttctgttca tgtttgtgtt 1980agatccgtgt ttgtgttaga tccgtgctgc
tagcgttcgt acacggatgc gacctgtacg 2040tcagacacgt tctgattgct
aacttgccag tgtttctctt tggggaatcc tgggatggct 2100ctagccgttc
cgcagacggg atcgatttca tgattttttt tgtttcgttg catagggttt
2160ggtttgccct tttcctttat ttcaatatat gccgtgcact tgtttgtcgg
gtcatctttt 2220catgcttttt tttgtcttgg ttgtgatgat gtggtctggt
tgggcggtcg ttctagatcg 2280gagtagaatt ctgtttcaaa ctacctggtg
gatttattaa ttttggatct gtatgtgtgt 2340gccatacata ttcatagtta
cgaattgaag atgatggatg gaaatatcga tctaggatag 2400gtatacatgt
tgatgcgggt tttactgatg catatacaga gatgcttttt gttcgcttgg
2460ttgtgatgat gtggtgtggt tgggcggtcg ttcattcgtt ctagatcgga
gtagaatact 2520gtttcaaact acctggtgta tttattaatt ttggaactgt
atgtgtgtgt catacatctt 2580catagttacg agtttaagat ggatggaaat
atcgatctag gataggtata catgttgatg 2640tgggttttac tgatgcatat
acatgatggc atatgcagca tctattcata tgctctaacc 2700ttgagtacct
atctattata ataaacaagt atgttttata attattttga tcttgatata
2760cttggatgat ggcatatgca gcagctatat gtggattttt ttagccctgc
cttcatacgc 2820tatttatttg cttggtactg tttcttttgt cgatgctcac
cctgttgttt ggtgttactt 2880ctgcaggtcg actctagagg atcaattcgc
tagcgaagtt cctattccga agttcctatt 2940ctctagaaag tataggaact
tcagatccac cgggatcccc gatcatgcaa aaactcatta 3000actcagtgca
aaactatgcc tggggcagca aaacggcgtt gactgaactt tatggtatgg
3060aaaatccgtc cagccagccg atggccgagc tgtggatggg cgcacatccg
aaaagcagtt 3120cacgagtgca gaatgccgcc ggagatatcg tttcactgcg
tgatgtgatt gagagtgata 3180aatcgactct gctcggagag gccgttgcca
aacgctttgg cgaactgcct ttcctgttca 3240aagtattatg cgcagcacag
ccactctcca ttcaggttca tccaaacaaa cacaattctg 3300aaatcggttt
tgccaaagaa aatgccgcag gtatcccgat ggatgccgcc gagcgtaact
3360ataaagatcc taaccacaag ccggagctgg tttttgcgct gacgcctttc
cttgcgatga 3420acgcgtttcg tgaattttcc gagattgtct ccctactcca
gccggtcgca ggtgcacatc 3480cggcgattgc tcacttttta caacagcctg
atgccgaacg tttaagcgaa ctgttcgcca 3540gcctgttgaa tatgcagggt
gaagaaaaat cccgcgcgct ggcgatttta aaatcggccc 3600tcgatagcca
gcagggtgaa ccgtggcaaa cgattcgttt aatttctgaa ttttacccgg
3660aagacagcgg tctgttctcc ccgctattgc tgaatgtggt gaaattgaac
cctggcgaag 3720cgatgttcct gttcgctgaa acaccgcacg cttacctgca
aggcgtggcg ctggaagtga 3780tggcaaactc cgataacgtg ctgcgtgcgg
gtctgacgcc taaatacatt gatattccgg 3840aactggttgc caatgtgaaa
ttcgaagcca aaccggctaa ccagttgttg acccagccgg 3900tgaaacaagg
tgcagaactg gacttcccga ttccagtgga tgattttgcc ttctcgctgc
3960atgaccttag tgataaagaa accaccatta gccagcagag tgccgccatt
ttgttctgcg 4020tcgaaggcga tgcaacgttg tggaaaggtt ctcagcagtt
acagcttaaa ccgggtgaat 4080cagcgtttat tgccgccaac gaatcaccgg
tgactgtcaa aggccacggc cgtttagcgc 4140gtgtttacaa caagctgtaa
gagcttactg aaaaaattaa catctcttgc taagctgggg 4200gtggaaccta
gacttgtcca tcttctggat tggccaactt aattaatgta tgaaataaaa
4260ggatgcacac atagtgacat gctaatcact ataatgtggg catcaaagtt
gtgtgttatg 4320tgtaattact agttatctga ataaaagaga aagagatcat
ccatatttct tatcctaaat 4380gaatgtcacg tgtctttata attctttgat
gaaccagatg catttcatta accaaatcca 4440tatacatata aatattaatc
atatataatt aatatcaatt gggttagcaa aacaaatcta 4500gtctaggtgt
gttttgcgaa tgcggcccta gcgtatacga agttcctatt ccgaagttcc
4560tattctccag aaagtatagg aacttctgta cacctgagct gattccgatg
acttcgtagg 4620ttcctagctc aagccgctcg tgtccaagcg tcacttacga
ttagctaatg attacggcat 4680ctaggaccga ctagctaact aactagtacc
gaggccggcc ccgcgggagc tcgctgatca 4740ctgatgagcc gagccgccat
gcattgtaat ttataacatg tgcggctgta cgcttccatc 4800tcaaatacct
ttttatatat atattgtact ttatagtcta cgacataatc tgccatggta
4860atttataaga tgtgctttat tgctcgttgt tctgttctca tctgtgtcca
tggcatggca 4920tggatacaaa atgtatgtat ggccacgcat ccaatctgtg
acgttgtcaa ggcagaggtc 4980caaccgtcca agaccctctt gtgccgccct
gtacttgcag tcagtgacgt tgtgagaaaa 5040agctgtgggt ggtctccgca
gagcgcgcgg gccacgagag ggagccccat ctctcggccg 5100aggggtacgg
gggctccaga cacggtcctt tggtttcttc tgcctgtagc gagcggcccc
5160gccccccacc gcgctgctag cctagccgat gctgatccat ccaccaccca
caagggattg 5220ttccacgact tgtggac 52372575427DNAArtificial
SequenceTS9Cas-2 donor 257agcaaggaac taaactgtta ttggacgcta
aagtttagta ctttatcttt aacatctttc 60agcatttcta tgtagatatt taagggctaa
attttagcaa gtgtgctgat aaattttagc 120ctaaatgttt ctgttgggct
aaattttagc aagtgtactg ttaaatttta gcatattcct 180tttagagtgg
tatgggtgtg catagactaa atgtttccgt tgggccctaa tttaacgatg
240tgtacgcagg cctgtttaga tgacttggta ccggcatatg gcctcgtact
gtttcatttg 300atgacgcgag cgtgcggccc atgcagcagc agcacgccgg
gaaggcagcg gattttgaag 360tactattgga cagcgcggcg cggggaccgg
gtcgttggcg cgcggtggag tgggggtggg 420tggtcctggc gtcctgccct
gcgcgatggt cgatggatgc cccatgcgcg tgtaaccgcc 480cagccgtcgc
catccgacca ggtgggcaga cgtacgtacg gtggcacgcc cacggcccat
540cggccatcgc gatcgcgttc gtatcgtgtc ctcaataacg aaagcgccaa
cggaaggcgc 600tgtcgtcgtc agttcaccgc gcgccggcgc cctgtgtcct
cgtccctctc gacttctcga 660ccagtaagaa ctctcgcgag ctgcggagct
gctggcgatg gccggccggt gggatccgac 720gtgcgtgcaa cctcgaattt
aaatcttaag cctaggataa cttcgtatag catacattat 780acgaagttat
ggcgccgcta gcctgcagtg cagcgtgacc cggtcgtgcc cctctctaga
840gataatgagc attgcatgtc taagttataa aaaattacca catatttttt
ttgtcacact 900tgtttgaagt gcagtttatc tatctttata catatattta
aactttactc tacgaataat 960ataatctata gtactacaat aatatcagtg
ttttagagaa tcatataaat gaacagttag 1020acatggtcta aaggacaatt
gagtattttg acaacaggac tctacagttt tatcttttta 1080gtgtgcatgt
gttctccttt ttttttgcaa atagcttcac ctatataata cttcatccat
1140tttattagta catccattta gggtttaggg ttaatggttt ttatagacta
atttttttag 1200tacatctatt ttattctatt ttagcctcta aattaagaaa
actaaaactc tattttagtt 1260tttttattta ataatttaga tataaaatag
aataaaataa agtgactaaa aattaaacaa 1320atacccttta agaaattaaa
aaaactaagg aaacattttt cttgtttcga gtagataatg 1380ccagcctgtt
aaacgccgtc gacgagtcta acggacacca accagcgaac cagcagcgtc
1440gcgtcgggcc aagcgaagca gacggcacgg catctctgtc gctgcctctg
gacccctctc 1500gagagttccg ctccaccgtt ggacttgctc cgctgtcggc
atccagaaat tgcgtggcgg 1560agcggcagac gtgagccggc acggcaggcg
gcctcctcct cctctcacgg caccggcagc 1620tacgggggat tcctttccca
ccgctccttc gctttccctt cctcgcccgc cgtaataaat 1680agacaccccc
tccacaccct ctttccccaa cctcgtgttg ttcggagcgc acacacacac
1740aaccagatct cccccaaatc cacccgtcgg cacctccgct tcaaggtacg
ccgctcgtcc 1800tccccccccc ccctctctac cttctctaga tcggcgttcc
ggtccatgca tggttagggc 1860ccggtagttc tacttctgtt catgtttgtg
ttagatccgt gtttgtgtta gatccgtgct 1920gctagcgttc gtacacggat
gcgacctgta cgtcagacac gttctgattg ctaacttgcc 1980agtgtttctc
tttggggaat cctgggatgg ctctagccgt tccgcagacg ggatcgattt
2040catgattttt tttgtttcgt tgcatagggt ttggtttgcc cttttccttt
atttcaatat 2100atgccgtgca cttgtttgtc gggtcatctt ttcatgcttt
tttttgtctt ggttgtgatg 2160atgtggtctg gttgggcggt cgttctagat
cggagtagaa ttctgtttca aactacctgg 2220tggatttatt aattttggat
ctgtatgtgt gtgccataca tattcatagt tacgaattga 2280agatgatgga
tggaaatatc gatctaggat aggtatacat gttgatgcgg gttttactga
2340tgcatataca gagatgcttt ttgttcgctt ggttgtgatg atgtggtgtg
gttgggcggt 2400cgttcattcg ttctagatcg gagtagaata ctgtttcaaa
ctacctggtg tatttattaa 2460ttttggaact gtatgtgtgt gtcatacatc
ttcatagtta cgagtttaag atggatggaa 2520atatcgatct aggataggta
tacatgttga tgtgggtttt actgatgcat atacatgatg 2580gcatatgcag
catctattca tatgctctaa ccttgagtac ctatctatta taataaacaa
2640gtatgtttta taattatttt gatcttgata tacttggatg atggcatatg
cagcagctat 2700atgtggattt ttttagccct gccttcatac gctatttatt
tgcttggtac tgtttctttt 2760gtcgatgctc accctgttgt ttggtgttac
ttctgcaggt cgactctaga ggatcaattc 2820gctagcgaag ttcctattcc
gaagttccta ttctctagaa agtataggaa cttcagatcc 2880accgggatcc
ccgatcatgc aaaaactcat taactcagtg caaaactatg cctggggcag
2940caaaacggcg ttgactgaac tttatggtat ggaaaatccg tccagccagc
cgatggccga 3000gctgtggatg ggcgcacatc cgaaaagcag ttcacgagtg
cagaatgccg ccggagatat 3060cgtttcactg cgtgatgtga ttgagagtga
taaatcgact ctgctcggag aggccgttgc 3120caaacgcttt ggcgaactgc
ctttcctgtt caaagtatta tgcgcagcac agccactctc 3180cattcaggtt
catccaaaca aacacaattc tgaaatcggt tttgccaaag aaaatgccgc
3240aggtatcccg atggatgccg ccgagcgtaa ctataaagat cctaaccaca
agccggagct 3300ggtttttgcg ctgacgcctt tccttgcgat gaacgcgttt
cgtgaatttt ccgagattgt 3360ctccctactc cagccggtcg caggtgcaca
tccggcgatt gctcactttt tacaacagcc 3420tgatgccgaa cgtttaagcg
aactgttcgc cagcctgttg aatatgcagg gtgaagaaaa 3480atcccgcgcg
ctggcgattt taaaatcggc cctcgatagc cagcagggtg aaccgtggca
3540aacgattcgt ttaatttctg aattttaccc ggaagacagc ggtctgttct
ccccgctatt 3600gctgaatgtg gtgaaattga accctggcga agcgatgttc
ctgttcgctg aaacaccgca 3660cgcttacctg caaggcgtgg cgctggaagt
gatggcaaac tccgataacg tgctgcgtgc 3720gggtctgacg cctaaataca
ttgatattcc ggaactggtt gccaatgtga aattcgaagc 3780caaaccggct
aaccagttgt tgacccagcc ggtgaaacaa ggtgcagaac tggacttccc
3840gattccagtg gatgattttg ccttctcgct gcatgacctt agtgataaag
aaaccaccat 3900tagccagcag agtgccgcca ttttgttctg cgtcgaaggc
gatgcaacgt tgtggaaagg 3960ttctcagcag ttacagctta aaccgggtga
atcagcgttt attgccgcca acgaatcacc 4020ggtgactgtc aaaggccacg
gccgtttagc gcgtgtttac aacaagctgt aagagcttac 4080tgaaaaaatt
aacatctctt gctaagctgg gggtggaacc tagacttgtc catcttctgg
4140attggccaac ttaattaatg tatgaaataa aaggatgcac acatagtgac
atgctaatca 4200ctataatgtg ggcatcaaag ttgtgtgtta tgtgtaatta
ctagttatct gaataaaaga 4260gaaagagatc atccatattt cttatcctaa
atgaatgtca cgtgtcttta taattctttg 4320atgaaccaga tgcatttcat
taaccaaatc catatacata taaatattaa tcatatataa 4380ttaatatcaa
ttgggttagc aaaacaaatc tagtctaggt gtgttttgcg aatgcggccc
4440tagcgtatac gaagttccta ttccgaagtt cctattctcc agaaagtata
ggaacttctg 4500tacacctgag ctgattccga tgacttcgta ggttcctagc
tcaagccgct cgtgtccaag 4560cgtcacttac gattagctaa tgattacggc
atctaggacc gactagctaa ctaactagta 4620ccgaggccgg ccccgcggga
gctcggccgc aaacagcctg gtgacagacg aagccagcaa 4680gcacgtacgt
acgcacgtct ctgctggtct ggatgtgtat ggatatggac gtctcacgtc
4740tggacgtcgt cgtcgccgtt gtattgtatc atgccaacca cttccgtacc
gtaccccctc 4800gcgtgccaac atgaccaccg ccggtacgtc tccatcgtcg
gccgtcggcg tctcaggcag 4860ctctcaatta agcggacgtg ttttggtaat
ctggtggaac gccgcgcgca ctgagggttt 4920gggggccccg gcggacgagc
gagcgagaga cggtgcatgc atgccaaatg gcaacgaggg 4980cccgcccgcc
catccaataa ccaacccaga cgtagcgcaa ccaacgtacg agtcctgtgc
5040tggcgcgtac gactaccacg ctagctgccg cgacatgcga actacggtcc
accaggcacc 5100agccatgaca atatatactg tatatatatt tttcttcttc
tttttgtttc cgctctctca 5160agttcctgct ctgctcctgc ctgtccgcgg
tgccgatcgg cgagagagca tgcatggaca 5220tggaccacgc gagatccagg
aaccggcacg ggcccatgcg tggcaggcgg ccgtttcgtc 5280aggttccccg
aaatgcccca actgcgcggc tgcaggatgg ctcatggctg gctgcctagc
5340tggcccgtga caccgatcga tcggtaacga cgacgcacgc acctgaagca
caggaaggag 5400cctccctctc gcatgcacgt tagtact
54272585426DNAArtificial SequenceTS9Cas-3 donor 258agcaaggaac
taaactgtta ttggacgcaa agtttagtac tttatcttta acatctttca 60gcatttctat
gtagatattt aagggctaaa ttttagcaag tgtgctgata aattttagcc
120taaatgtttc tgttgggcta aattttagca agtgtactgt taaattttag
catattcctt 180ttagagtggt atgggtgtgc atagactaaa tgtttccgtt
gggccctaat ttaacgatgt 240gtacgcaggc ctgtttagat gacttggtac
cggcatatgg cctcgtactg tttcatttga 300tgacgcgagc gtgcggccca
tgcagcagca gcacgccggg aaggcagcgg attttgaagt 360actattggac
agcgcggcgc ggggaccggg tcgttggcgc gcggtggagt gggggtgggt
420ggtcctggcg tcctgccctg cgcgatggtc gatggatgcc ccatgcgcgt
gtaaccgccc 480agccgtcgcc atccgaccag gtgggcagac gtacgtacgg
tggcacgccc acggcccatc 540ggccatcgcg atcgcgttcg tatcgtgtcc
tcaataacga aagcgccaac ggaaggcgct 600gtcgtcgtca gttcaccgcg
cgccggcgcc ctgtgtcctc gtccctctcg acttctcgac 660cagtaagaac
tctcgcgagc tgcggagctg ctggcgatgg ccggccggtg ggatccgacg
720atttaaatct taagcctagg ataacttcgt atagcataca ttatacgaag
ttatggcgcc 780gctagcctgc agtgcagcgt gacccggtcg tgcccctctc
tagagataat gagcattgca 840tgtctaagtt ataaaaaatt accacatatt
ttttttgtca cacttgtttg aagtgcagtt 900tatctatctt tatacatata
tttaaacttt actctacgaa taatataatc tatagtacta 960caataatatc
agtgttttag agaatcatat aaatgaacag ttagacatgg tctaaaggac
1020aattgagtat tttgacaaca ggactctaca gttttatctt tttagtgtgc
atgtgttctc 1080cttttttttt gcaaatagct tcacctatat aatacttcat
ccattttatt agtacatcca 1140tttagggttt agggttaatg gtttttatag
actaattttt ttagtacatc tattttattc 1200tattttagcc tctaaattaa
gaaaactaaa actctatttt agttttttta tttaataatt 1260tagatataaa
atagaataaa ataaagtgac taaaaattaa acaaataccc tttaagaaat
1320taaaaaaact aaggaaacat ttttcttgtt tcgagtagat aatgccagcc
tgttaaacgc 1380cgtcgacgag tctaacggac accaaccagc gaaccagcag
cgtcgcgtcg ggccaagcga 1440agcagacggc acggcatctc tgtcgctgcc
tctggacccc tctcgagagt tccgctccac 1500cgttggactt gctccgctgt
cggcatccag aaattgcgtg gcggagcggc agacgtgagc 1560cggcacggca
ggcggcctcc tcctcctctc acggcaccgg cagctacggg ggattccttt
1620cccaccgctc cttcgctttc ccttcctcgc ccgccgtaat aaatagacac
cccctccaca 1680ccctctttcc ccaacctcgt gttgttcgga gcgcacacac
acacaaccag atctccccca 1740aatccacccg tcggcacctc cgcttcaagg
tacgccgctc gtcctccccc ccccccctct 1800ctaccttctc tagatcggcg
ttccggtcca tgcatggtta gggcccggta gttctacttc 1860tgttcatgtt
tgtgttagat ccgtgtttgt gttagatccg tgctgctagc gttcgtacac
1920ggatgcgacc tgtacgtcag acacgttctg attgctaact tgccagtgtt
tctctttggg 1980gaatcctggg atggctctag ccgttccgca gacgggatcg
atttcatgat tttttttgtt 2040tcgttgcata gggtttggtt tgcccttttc
ctttatttca atatatgccg tgcacttgtt 2100tgtcgggtca tcttttcatg
cttttttttg tcttggttgt gatgatgtgg tctggttggg 2160cggtcgttct
agatcggagt agaattctgt ttcaaactac ctggtggatt tattaatttt
2220ggatctgtat gtgtgtgcca tacatattca tagttacgaa ttgaagatga
tggatggaaa 2280tatcgatcta ggataggtat acatgttgat gcgggtttta
ctgatgcata tacagagatg 2340ctttttgttc gcttggttgt gatgatgtgg
tgtggttggg cggtcgttca ttcgttctag 2400atcggagtag aatactgttt
caaactacct ggtgtattta ttaattttgg aactgtatgt 2460gtgtgtcata
catcttcata gttacgagtt taagatggat ggaaatatcg atctaggata
2520ggtatacatg ttgatgtggg ttttactgat gcatatacat gatggcatat
gcagcatcta 2580ttcatatgct ctaaccttga gtacctatct attataataa
acaagtatgt tttataatta 2640ttttgatctt gatatacttg gatgatggca
tatgcagcag ctatatgtgg atttttttag 2700ccctgccttc atacgctatt
tatttgcttg gtactgtttc ttttgtcgat gctcaccctg 2760ttgtttggtg
ttacttctgc aggtcgactc tagaggatca attcgctagc gaagttccta
2820ttccgaagtt cctattctct agaaagtata ggaacttcag atccaccggg
atccccgatc 2880atgcaaaaac tcattaactc agtgcaaaac tatgcctggg
gcagcaaaac ggcgttgact 2940gaactttatg gtatggaaaa tccgtccagc
cagccgatgg ccgagctgtg gatgggcgca 3000catccgaaaa gcagttcacg
agtgcagaat gccgccggag atatcgtttc actgcgtgat 3060gtgattgaga
gtgataaatc gactctgctc ggagaggccg ttgccaaacg ctttggcgaa
3120ctgcctttcc tgttcaaagt attatgcgca gcacagccac tctccattca
ggttcatcca 3180aacaaacaca attctgaaat cggttttgcc aaagaaaatg
ccgcaggtat cccgatggat 3240gccgccgagc gtaactataa agatcctaac
cacaagccgg agctggtttt tgcgctgacg 3300cctttccttg cgatgaacgc
gtttcgtgaa ttttccgaga ttgtctccct actccagccg 3360gtcgcaggtg
cacatccggc gattgctcac tttttacaac agcctgatgc cgaacgttta
3420agcgaactgt tcgccagcct gttgaatatg cagggtgaag aaaaatcccg
cgcgctggcg 3480attttaaaat cggccctcga tagccagcag ggtgaaccgt
ggcaaacgat tcgtttaatt 3540tctgaatttt acccggaaga cagcggtctg
ttctccccgc tattgctgaa tgtggtgaaa 3600ttgaaccctg gcgaagcgat
gttcctgttc gctgaaacac cgcacgctta cctgcaaggc 3660gtggcgctgg
aagtgatggc aaactccgat aacgtgctgc gtgcgggtct gacgcctaaa
3720tacattgata ttccggaact ggttgccaat gtgaaattcg aagccaaacc
ggctaaccag 3780ttgttgaccc agccggtgaa acaaggtgca gaactggact
tcccgattcc agtggatgat 3840tttgccttct cgctgcatga ccttagtgat
aaagaaacca ccattagcca gcagagtgcc 3900gccattttgt tctgcgtcga
aggcgatgca acgttgtgga aaggttctca gcagttacag 3960cttaaaccgg
gtgaatcagc gtttattgcc gccaacgaat caccggtgac tgtcaaaggc
4020cacggccgtt tagcgcgtgt ttacaacaag ctgtaagagc ttactgaaaa
aattaacatc 4080tcttgctaag ctgggggtgg aacctagact tgtccatctt
ctggattggc caacttaatt 4140aatgtatgaa ataaaaggat gcacacatag
tgacatgcta atcactataa tgtgggcatc 4200aaagttgtgt gttatgtgta
attactagtt atctgaataa aagagaaaga gatcatccat 4260atttcttatc
ctaaatgaat gtcacgtgtc tttataattc tttgatgaac cagatgcatt
4320tcattaacca aatccatata catataaata ttaatcatat ataattaata
tcaattgggt 4380tagcaaaaca aatctagtct aggtgtgttt tgcgaatgcg
gccctagcgt atacgaagtt 4440cctattccga agttcctatt ctccagaaag
tataggaact tctgtacacc tgagctgatt 4500ccgatgactt cgtaggttcc
tagctcaagc cgctcgtgtc caagcgtcac ttacgattag 4560ctaatgatta
cggcatctag gaccgactag ctaactaact agtaccgagg ccggccccgc
4620gggagctctg cgtgcaacct cgaggccgca aacagcctgg tgacagacga
agccagcaag 4680cacgtacgta cgcacgtctc tgctggtctg gatgtgtatg
gatatggacg tctcacgtct 4740ggacgtcgtc gtcgccgttg tattgtatca
tgccaaccac ttccgtaccg taccccctcg 4800cgtgccaaca tgaccaccgc
cggtacgtct ccatcgtcgg ccgtcggcgt ctcaggcagc 4860tctcaattaa
gcggacgtgt tttggtaatc tggtggaacg ccgcgcgcac tgagggtttg
4920ggggccccgg cggacgagcg agcgagagac ggtgcatgca tgccaaatgg
caacgagggc 4980ccgcccgccc atccaataac caacccagac gtagcgcaac
caacgtacga gtcctgtgct 5040ggcgcgtacg actaccacgc tagctgccgc
gacatgcgaa ctacggtcca ccaggcacca 5100gccatgacaa tatatactgt
atatatattt ttcttcttct ttttgtttcc gctctctcaa 5160gttcctgctc
tgctcctgcc tgtccgcggt gccgatcggc gagagagcat gcatggacat
5220ggaccacgcg agatccagga accggcacgg gcccatgcgt ggcaggcggc
cgtttcgtca 5280ggttccccga aatgccccaa ctgcgcggct gcaggatggc
tcatggctgg ctgcctagct 5340ggcccgtgac accgatcgat cggtaacgac
gacgcacgca cctgaagcac aggaaggagc 5400ctccctctcg catgcacgtt agtact
54262595152DNAArtificial SequenceTS10Cas-1 donor 259ggtaccaaat
agtaaacggg aggggaggtc gctagtagta aacgctaggt agctaggata 60atccgtctcg
tgttggacgg aaggttttgg acgcatctgc gtgcacagcc cgctgataca
120gatctgatcg actagctagc tagatgccga ggccccagag caaggcccgg
atactcctgc 180acagtccctg agatttcagc acagcaggtg ctgttgcatc
aatatataaa tccctgcttt 240attaatttaa tctctgtgca tgtatccata
catcgtcagc ggctcagcgc tatcacactg 300cagtgcacgc agctagttga
gcgcctgggt cagtatatat atagctagta gggacaaagg 360ggggcactgt
acgttggttt ggtttggcac gcacgcgatc gagagtggtg gaatggactg
420cagatcatcg atcgctgcac tgtacgcacg cgcaccggac tgcatttgca
tgcccctgaa 480ggaggaaagg ggaaggaaag aaaagaaata ggagaaagaa
gaagaagcag agaaatacgt 540cacagtccaa gaagagtgag ccgccctagc
tagcttcaac cctgacgaac ccggcagcca 600cacttccggc catgtatgca
tgcatgcatg gcttagcttc agatgtccaa tcgaatccat 660caagacctgg
ccggttttcc atggccgcct cgccttcgct agtggtacca tttaaatctt
720aagcctagga taacttcgta tagcatacat tatacgaagt tatggcgccg
ctagcctgca 780gtgcagcgtg acccggtcgt gcccctctct agagataatg
agcattgcat gtctaagtta 840taaaaaatta ccacatattt tttttgtcac
acttgtttga agtgcagttt atctatcttt 900atacatatat ttaaacttta
ctctacgaat aatataatct atagtactac aataatatca 960gtgttttaga
gaatcatata aatgaacagt tagacatggt ctaaaggaca attgagtatt
1020ttgacaacag gactctacag ttttatcttt ttagtgtgca tgtgttctcc
tttttttttg 1080caaatagctt cacctatata atacttcatc cattttatta
gtacatccat ttagggttta 1140gggttaatgg tttttataga ctaatttttt
tagtacatct attttattct attttagcct 1200ctaaattaag aaaactaaaa
ctctatttta gtttttttat ttaataattt agatataaaa 1260tagaataaaa
taaagtgact aaaaattaaa caaataccct ttaagaaatt aaaaaaacta
1320aggaaacatt tttcttgttt cgagtagata atgccagcct gttaaacgcc
gtcgacgagt 1380ctaacggaca ccaaccagcg aaccagcagc gtcgcgtcgg
gccaagcgaa gcagacggca 1440cggcatctct gtcgctgcct ctggacccct
ctcgagagtt ccgctccacc gttggacttg 1500ctccgctgtc ggcatccaga
aattgcgtgg cggagcggca gacgtgagcc ggcacggcag 1560gcggcctcct
cctcctctca cggcaccggc agctacgggg gattcctttc ccaccgctcc
1620ttcgctttcc cttcctcgcc cgccgtaata aatagacacc ccctccacac
cctctttccc 1680caacctcgtg ttgttcggag cgcacacaca cacaaccaga
tctcccccaa atccacccgt 1740cggcacctcc gcttcaaggt acgccgctcg
tcctcccccc cccccctctc taccttctct 1800agatcggcgt tccggtccat
gcatggttag ggcccggtag ttctacttct gttcatgttt 1860gtgttagatc
cgtgtttgtg ttagatccgt gctgctagcg ttcgtacacg gatgcgacct
1920gtacgtcaga cacgttctga ttgctaactt gccagtgttt ctctttgggg
aatcctggga 1980tggctctagc cgttccgcag acgggatcga tttcatgatt
ttttttgttt cgttgcatag 2040ggtttggttt gcccttttcc tttatttcaa
tatatgccgt gcacttgttt gtcgggtcat 2100cttttcatgc ttttttttgt
cttggttgtg atgatgtggt ctggttgggc ggtcgttcta 2160gatcggagta
gaattctgtt tcaaactacc tggtggattt attaattttg gatctgtatg
2220tgtgtgccat acatattcat agttacgaat tgaagatgat ggatggaaat
atcgatctag 2280gataggtata catgttgatg cgggttttac tgatgcatat
acagagatgc tttttgttcg 2340cttggttgtg atgatgtggt gtggttgggc
ggtcgttcat tcgttctaga tcggagtaga 2400atactgtttc aaactacctg
gtgtatttat taattttgga actgtatgtg tgtgtcatac 2460atcttcatag
ttacgagttt aagatggatg gaaatatcga tctaggatag gtatacatgt
2520tgatgtgggt tttactgatg catatacatg atggcatatg cagcatctat
tcatatgctc 2580taaccttgag tacctatcta ttataataaa caagtatgtt
ttataattat tttgatcttg 2640atatacttgg atgatggcat atgcagcagc
tatatgtgga tttttttagc cctgccttca 2700tacgctattt atttgcttgg
tactgtttct tttgtcgatg ctcaccctgt tgtttggtgt 2760tacttctgca
ggtcgactct agaggatcaa ttcgctagcg aagttcctat tccgaagttc
2820ctattctcta gaaagtatag gaacttcaga tccaccggga tccccgatca
tgcaaaaact 2880cattaactca gtgcaaaact atgcctgggg cagcaaaacg
gcgttgactg aactttatgg 2940tatggaaaat ccgtccagcc agccgatggc
cgagctgtgg atgggcgcac atccgaaaag 3000cagttcacga gtgcagaatg
ccgccggaga tatcgtttca ctgcgtgatg tgattgagag 3060tgataaatcg
actctgctcg gagaggccgt tgccaaacgc tttggcgaac tgcctttcct
3120gttcaaagta ttatgcgcag cacagccact ctccattcag gttcatccaa
acaaacacaa 3180ttctgaaatc ggttttgcca aagaaaatgc cgcaggtatc
ccgatggatg ccgccgagcg 3240taactataaa gatcctaacc acaagccgga
gctggttttt gcgctgacgc ctttccttgc 3300gatgaacgcg tttcgtgaat
tttccgagat tgtctcccta ctccagccgg tcgcaggtgc 3360acatccggcg
attgctcact ttttacaaca gcctgatgcc gaacgtttaa gcgaactgtt
3420cgccagcctg ttgaatatgc agggtgaaga aaaatcccgc gcgctggcga
ttttaaaatc 3480ggccctcgat agccagcagg gtgaaccgtg gcaaacgatt
cgtttaattt ctgaatttta 3540cccggaagac agcggtctgt tctccccgct
attgctgaat gtggtgaaat tgaaccctgg 3600cgaagcgatg ttcctgttcg
ctgaaacacc gcacgcttac ctgcaaggcg tggcgctgga 3660agtgatggca
aactccgata acgtgctgcg tgcgggtctg acgcctaaat acattgatat
3720tccggaactg gttgccaatg tgaaattcga agccaaaccg gctaaccagt
tgttgaccca 3780gccggtgaaa caaggtgcag aactggactt cccgattcca
gtggatgatt ttgccttctc 3840gctgcatgac cttagtgata aagaaaccac
cattagccag cagagtgccg ccattttgtt 3900ctgcgtcgaa ggcgatgcaa
cgttgtggaa aggttctcag cagttacagc ttaaaccggg 3960tgaatcagcg
tttattgccg ccaacgaatc accggtgact gtcaaaggcc acggccgttt
4020agcgcgtgtt tacaacaagc tgtaagagct tactgaaaaa attaacatct
cttgctaagc 4080tgggggtgga acctagactt gtccatcttc tggattggcc
aacttaatta atgtatgaaa 4140taaaaggatg cacacatagt gacatgctaa
tcactataat gtgggcatca aagttgtgtg 4200ttatgtgtaa ttactagtta
tctgaataaa agagaaagag atcatccata tttcttatcc 4260taaatgaatg
tcacgtgtct ttataattct ttgatgaacc agatgcattt cattaaccaa
4320atccatatac atataaatat taatcatata taattaatat caattgggtt
agcaaaacaa 4380atctagtcta ggtgtgtttt gcgaatgcgg ccctagcgta
tacgaagttc ctattccgaa 4440gttcctattc tccagaaagt ataggaactt
ctgtacacct gagctgattc cgatgacttc 4500gtaggttcct agctcaagcc
gctcgtgtcc aagcgtcact tacgattagc taatgattac 4560ggcatctagg
accgactagc taactaacta gtaccgaggc cggccccgcg ggagctcggc
4620gcgcctaagg gccaagtact tgctgtccct gtatctccaa cacgagcctt
gattcctgcc 4680ggccggtgat ggcaatggcc gctagtagtc tccgctagct
agggagcggc gatccgacgc 4740gacgccacca tgtgtctaga aaagaagttt
cttgctttgc atgcagactt attagcgcgg 4800tcgacacctg tggggacccc
gtgtcttgag acaatgagac tgcctgtccg cccaagacac 4860tacttgtagc
catgaagcca tcgactcctc tccttgctct ccagtaatcc agtggatgga
4920tccatcatcg atagtttagt ttatcagtct tcttgaggcc ggtgtccccc
atgcataatg 4980atgacagaaa gcctgggcca ggtaaaagcc aaaaagtttg
accctctagg tactggggcc 5040agccctggcg tttgaacaaa aaaaaaatct
gagcgtgtcg ccccggcctg ttttcgaact 5100cctaaacgac gtcgcaactt
tttttataca cacactaccg gtacatggct tt 51522605146DNAArtificial
SequenceTS10Cas-3 donor 260aaatagtaaa cgggagggga ggtcgctagt
agtaaacgct aggtagctag gataatccgt 60ctcgtgttgg acggaaggtt ttggacgcat
ctgcgtgcac agcccgctga tacagatctg 120atcgactagc tagctagatg
ccgaggcccc agagcaaggc ccggatactc ctgcacagtc 180cctgagattt
cagcacagca ggtgctgttg catcaatata taaatccctg ctttattaat
240ttaatctctg tgcatgtatc catacatcgt cagcggctca gcgctatcac
actgcagtgc 300acgcagctag ttgagcgcct gggtcagtat atatatagct
agtagggaca aaggggggca 360ctgtacgttg gtttggtttg gcacgcacgc
gatcgagagt ggtggaatgg actgcagatc 420atcgatcgct gcactgtacg
cacgcgcacc ggactgcatt tgcatgcccc tgaaggagga 480aaggggaagg
aaagaaaaga aataggagaa agaagaagaa gcagagaaat acgtcacagt
540ccaagaagag tgagccgccc tagctagctt caaccctgac gaacccggca
gccacacttc 600cggccatgta tgcatgcatg catggcttag cttcagatgt
ccaatcgaat ccatcaagac 660ctggccggtt ttccatggcc gcctcgcctt
cgctagttaa gggccaagta cttgctgtcc 720ctgtggtacc atttaaatct
taagcctagg ataacttcgt atagcataca ttatacgaag 780ttatggcgcc
gctagcctgc agtgcagcgt gacccggtcg tgcccctctc tagagataat
840gagcattgca tgtctaagtt ataaaaaatt accacatatt ttttttgtca
cacttgtttg 900aagtgcagtt tatctatctt tatacatata tttaaacttt
actctacgaa taatataatc 960tatagtacta caataatatc agtgttttag
agaatcatat aaatgaacag ttagacatgg 1020tctaaaggac aattgagtat
tttgacaaca ggactctaca gttttatctt tttagtgtgc 1080atgtgttctc
cttttttttt gcaaatagct tcacctatat aatacttcat ccattttatt
1140agtacatcca tttagggttt agggttaatg gtttttatag actaattttt
ttagtacatc 1200tattttattc tattttagcc tctaaattaa gaaaactaaa
actctatttt agttttttta 1260tttaataatt tagatataaa atagaataaa
ataaagtgac taaaaattaa acaaataccc 1320tttaagaaat taaaaaaact
aaggaaacat ttttcttgtt tcgagtagat aatgccagcc 1380tgttaaacgc
cgtcgacgag tctaacggac accaaccagc gaaccagcag cgtcgcgtcg
1440ggccaagcga agcagacggc acggcatctc tgtcgctgcc tctggacccc
tctcgagagt 1500tccgctccac cgttggactt gctccgctgt cggcatccag
aaattgcgtg gcggagcggc 1560agacgtgagc cggcacggca ggcggcctcc
tcctcctctc acggcaccgg cagctacggg 1620ggattccttt cccaccgctc
cttcgctttc ccttcctcgc ccgccgtaat aaatagacac 1680cccctccaca
ccctctttcc ccaacctcgt gttgttcgga gcgcacacac acacaaccag
1740atctccccca aatccacccg tcggcacctc cgcttcaagg tacgccgctc
gtcctccccc 1800ccccccctct ctaccttctc tagatcggcg ttccggtcca
tgcatggtta gggcccggta 1860gttctacttc tgttcatgtt tgtgttagat
ccgtgtttgt gttagatccg tgctgctagc 1920gttcgtacac ggatgcgacc
tgtacgtcag acacgttctg attgctaact tgccagtgtt 1980tctctttggg
gaatcctggg atggctctag ccgttccgca gacgggatcg atttcatgat
2040tttttttgtt tcgttgcata gggtttggtt tgcccttttc ctttatttca
atatatgccg 2100tgcacttgtt tgtcgggtca tcttttcatg cttttttttg
tcttggttgt gatgatgtgg 2160tctggttggg cggtcgttct agatcggagt
agaattctgt ttcaaactac ctggtggatt 2220tattaatttt ggatctgtat
gtgtgtgcca tacatattca tagttacgaa ttgaagatga 2280tggatggaaa
tatcgatcta ggataggtat acatgttgat gcgggtttta ctgatgcata
2340tacagagatg ctttttgttc gcttggttgt gatgatgtgg tgtggttggg
cggtcgttca 2400ttcgttctag atcggagtag aatactgttt caaactacct
ggtgtattta ttaattttgg 2460aactgtatgt gtgtgtcata catcttcata
gttacgagtt taagatggat ggaaatatcg 2520atctaggata ggtatacatg
ttgatgtggg ttttactgat gcatatacat gatggcatat 2580gcagcatcta
ttcatatgct ctaaccttga gtacctatct attataataa acaagtatgt
2640tttataatta ttttgatctt gatatacttg gatgatggca tatgcagcag
ctatatgtgg 2700atttttttag ccctgccttc atacgctatt tatttgcttg
gtactgtttc ttttgtcgat 2760gctcaccctg ttgtttggtg ttacttctgc
aggtcgactc tagaggatca attcgctagc 2820gaagttccta ttccgaagtt
cctattctct agaaagtata ggaacttcag atccaccggg 2880atccccgatc
atgcaaaaac tcattaactc agtgcaaaac tatgcctggg gcagcaaaac
2940ggcgttgact gaactttatg gtatggaaaa tccgtccagc cagccgatgg
ccgagctgtg 3000gatgggcgca catccgaaaa gcagttcacg agtgcagaat
gccgccggag atatcgtttc 3060actgcgtgat gtgattgaga gtgataaatc
gactctgctc ggagaggccg ttgccaaacg 3120ctttggcgaa ctgcctttcc
tgttcaaagt attatgcgca gcacagccac tctccattca 3180ggttcatcca
aacaaacaca attctgaaat cggttttgcc aaagaaaatg ccgcaggtat
3240cccgatggat gccgccgagc gtaactataa agatcctaac cacaagccgg
agctggtttt 3300tgcgctgacg cctttccttg cgatgaacgc gtttcgtgaa
ttttccgaga ttgtctccct 3360actccagccg gtcgcaggtg cacatccggc
gattgctcac tttttacaac agcctgatgc 3420cgaacgttta agcgaactgt
tcgccagcct gttgaatatg cagggtgaag aaaaatcccg 3480cgcgctggcg
attttaaaat cggccctcga tagccagcag ggtgaaccgt ggcaaacgat
3540tcgtttaatt tctgaatttt acccggaaga cagcggtctg ttctccccgc
tattgctgaa 3600tgtggtgaaa ttgaaccctg gcgaagcgat gttcctgttc
gctgaaacac cgcacgctta 3660cctgcaaggc gtggcgctgg aagtgatggc
aaactccgat aacgtgctgc gtgcgggtct 3720gacgcctaaa tacattgata
ttccggaact ggttgccaat gtgaaattcg aagccaaacc 3780ggctaaccag
ttgttgaccc agccggtgaa acaaggtgca gaactggact tcccgattcc
3840agtggatgat tttgccttct cgctgcatga ccttagtgat aaagaaacca
ccattagcca 3900gcagagtgcc gccattttgt tctgcgtcga aggcgatgca
acgttgtgga aaggttctca 3960gcagttacag cttaaaccgg gtgaatcagc
gtttattgcc gccaacgaat caccggtgac 4020tgtcaaaggc cacggccgtt
tagcgcgtgt ttacaacaag ctgtaagagc ttactgaaaa 4080aattaacatc
tcttgctaag ctgggggtgg aacctagact tgtccatctt ctggattggc
4140caacttaatt aatgtatgaa ataaaaggat gcacacatag tgacatgcta
atcactataa 4200tgtgggcatc aaagttgtgt gttatgtgta attactagtt
atctgaataa aagagaaaga 4260gatcatccat atttcttatc ctaaatgaat
gtcacgtgtc tttataattc tttgatgaac 4320cagatgcatt tcattaacca
aatccatata catataaata ttaatcatat ataattaata 4380tcaattgggt
tagcaaaaca aatctagtct aggtgtgttt tgcgaatgcg gccctagcgt
4440atacgaagtt cctattccga agttcctatt ctccagaaag tataggaact
tctgtacacc 4500tgagctgatt ccgatgactt cgtaggttcc tagctcaagc
cgctcgtgtc caagcgtcac 4560ttacgattag ctaatgatta
cggcatctag gaccgactag ctaactaact agtaccgagg 4620ccggccccgc
gggagctcgg cgcgccatct ccaacacgag ccttgattcc tgccggccgg
4680tgatggcaat ggccgctagt agtctccgct agctagggag cggcgatccg
acgcgacgcc 4740accatgtgtc tagaaaagaa gtttcttgct ttgcatgcag
acttattagc gcggtcgaca 4800cctgtgggga ccccgtgtct tgagacaatg
agactgcctg tccgcccaag acactacttg 4860tagccatgaa gccatcgact
cctctccttg ctctccagta atccagtgga tggatccatc 4920atcgatagtt
tagtttatca gtcttcttga ggccggtgtc ccccatgcat aatgatgaca
4980gaaagcctgg gccaggtaaa agccaaaaag tttgaccctc taggtactgg
ggccagccct 5040ggcgtttgaa caaaaaaaaa atctgagcgt gtcgccccgg
cctgttttcg aactcctaaa 5100cgacgtcgca acttttttta tacacacact
accggtacat ggcttt 514626132DNAArtificial Sequenceubir primer from
donor 261ccatgtctaa ctgttcattt atatgattct ct 3226231DNAArtificial
Sequencepsbf primer from dono 262gctcgtgtcc aagcgtcact tacgattagc t
3126327DNAArtificial SequencesMHP14 14-1HR1f primer 263ctcacatgag
gctcttcttt gcttgct 2726426DNAArtificial SequenceMHP14 14-1HR2r
primer 264aggatcctat tccccaattt gtagat 2626521DNAArtificial
SequenceCHR1-8 8HR1f primer 265cagtccgtgg attgaagcca t
2126622DNAArtificial SequenceCHR1-8 8HR2r primer 266ctctgtctcc
gagacgtgct ta 2226726DNAArtificial SequenceCHR1-9 9HR1f primer
267ggagcaaatg ttttaggtat gaaatg 2626828DNAArtificial SequenceCHR1-9
9HR2r primer 268cggattctaa agatcatacg taaatgaa 2826921DNAArtificial
SequenceCHR1-10 10HR1f primer 269tggcttgtct atgcgcatct c
2127020DNAArtificial SequenceCHR1-10 10HR2r primer 270ccagacccaa
acagcaggtt 2027118DNAArtificial SequenceMHP14Cas-1 probe
271cagattcacg tcagattt 1827227DNAArtificial SequenceMHP14cas-1
forward primer 272catagtggtg tatgaaagga agcactt
2727330DNAArtificial SequenceMHP14cas-1 reverse primer
273cattttggat tgtaatatgt gtacctcata 3027417DNAArtificial
SequenceMHP14Cas-3 probe 274caccactatg tcgcttc 1727522DNAArtificial
SequenceMHP14Cas-3 forward primer 275cggatgcacg aaaattgtag ga
2227624DNAArtificial SequenceMHP14Cas-3 reverse primer
276ctgacgtgaa tctgtttgga attg 2427718DNAArtificial SequenceTS8Cas-1
probe 277tacgtaacgt gcagtact 1827821DNAArtificial SequenceTS8Cas-1
forward primer 278acggacggac catacgttat g 2127926DNAArtificial
SequenceTS8Cas-1 reverse primer 279tcagctggtg gagtatatta gttcgt
2628018DNAArtificial SequenceTS8Cas-2 probe 280ccagctgatc actgatga
1828121DNAArtificial SequenceTS8Cas-2 forward primer 281acggacggac
catacgttat g 2128226DNAArtificial SequenceTS8Cas-2 reverse primer
282cgcacatgtt ataaattaca atgcat 2628314DNAArtificial
SequenceTS9Cas-2 probe 283ctgtttgcgg cctc 1428419DNAArtificial
SequenceTS9Cas-2 forward primer 284ctgcggagct gctggcgat
1928520DNAArtificial SequenceTS9Cas-2 reverse primer 285cttgctggct
tcgtctgtca 2028615DNAArtificial SequenceTS9Cas-3 probe
286ccgacgtgcg tgcaa 1528719DNAArtificial SequenceTS9Cas-3 forward
primer 287ctgcggagct gctggcgat 1928820DNAArtificial
SequenceTS9Cas-3 reverse primer 288cttgctggct tcgtctgtca
2028917DNAArtificial SequenceTS10Cas-1 probe 289tcgccttcgc tagttaa
1729020DNAArtificial SequenceTS10Cas-1 forward primer 290aagacctggc
cggttttcca 2029118DNAArtificial SequenceTS10Cas-1 reverse primer
291tagcggccat tgccatca 1829219DNAArtificial SequenceTS10Cas-3 probe
292ctgtatctcc aacacgagc 1929320DNAArtificial SequenceTS10Cas-3
forward primer 293aagacctggc cggttttcca 2029418DNAArtificial
SequenceTS10Cas-3 reverse primer 294tagcggccat tgccatca
18295472DNAGlycine maxGM-U6-9.1 promoter(1)..(472) 295cccgggttaa
gagaattgta agtgtgcttt tatatattta aaattaatat attttgaaat 60gttaaaatat
aaaagaaaat tcaatgtaaa ttaaaaataa ataaatgttt aataaagata
120aattttaaaa cataaaagaa aatgtctaac aagaggatta agatcctgtg
ctcttaaatt 180tttaggtgtt gaaatcttag ccatacaaaa tatattttat
taaaaccaag catgaaaaaa 240gtcactaaag agctatataa ctcatgcagc
tagaaatgaa gtgaagggaa tccagtttgt 300tctcagtcga aagagtgtct
atctttgttc ttttctgcaa ccgagttaag caaaatggga 360atgcgaggta
tcttcctttc gttaggggag caccagatgc atagttagtc ccacattgat
420gaatataaca agagcttcac agaatatata gcccaggcca cagtaaaagc tt
4722965958DNAArtificial sequenceEF1A2-CAS9 296gggtttactt attttgtggg
tatctatact tttattagat ttttaatcag gctcctgatt 60tctttttatt tcgattgaat
tcctgaactt gtattattca gtagatcgaa taaattataa 120aaagataaaa
tcataaaata atattttatc ctatcaatca tattaaagca atgaatatgt
180aaaattaatc ttatctttat tttaaaaaat catataggtt tagtattttt
ttaaaaataa 240agataggatt agttttacta ttcactgctt attactttta
aaaaaatcat aaaggtttag 300tattttttta aaataaatat aggaatagtt
ttactattca ctgctttaat agaaaaatag 360tttaaaattt aagatagttt
taatcccagc atttgccacg tttgaacgtg agccgaaacg 420atgtcgttac
attatcttaa cctagctgaa acgatgtcgt cataatatcg ccaaatgcca
480actggactac gtcgaaccca caaatcccac aaagcgcgtg aaatcaaatc
gctcaaacca 540caaaaaagaa caacgcgttt gttacacgct caatcccacg
cgagtagagc acagtaacct 600tcaaataagc gaatggggca taatcagaaa
tccgaaataa acctaggggc attatcggaa 660atgaaaagta gctcactcaa
tataaaaatc taggaaccct agttttcgtt atcactctgt 720gctccctcgc
tctatttctc agtctctgtg tttgcggctg aggattccga acgagtgacc
780ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc tcttcgattc
gatctatgcc 840tgtctcttat ttacgatgat gtttcttcgg ttatgttttt
ttatttatgc tttatgctgt 900tgatgttcgg ttgtttgttt cgctttgttt
ttgtggttca gttttttagg attcttttgg 960tttttgaatc gattaatcgg
aagagatttt cgagttattt ggtgtgttgg aggtgaatct 1020tttttttgag
gtcatagatc tgttgtattt gtgttataaa catgcgactt tgtatgattt
1080tttacgaggt tatgatgttc tggttgtttt attatgaatc tgttgagaca
gaaccatgat 1140ttttgttgat gttcgtttac actattaaag gtttgtttta
acaggattaa aagtttttta 1200agcatgttga aggagtcttg tagatatgta
accgtcgata gtttttttgt gggtttgttc 1260acatgttatc aagcttaatc
ttttactatg tatgcgacca tatctggatc cagcaaaggc 1320gattttttaa
ttccttgtga aacttttgta atatgaagtt gaaattttgt tattggtaaa
1380ctataaatgt gtgaagttgg agtatacctt taccttctta tttggctttg
tgatagttta 1440atttatatgt attttgagtt ctgacttgta tttctttgaa
ttgattctag tttaagtaat 1500ccatggacaa aaagtactca atagggctcg
acatagggac taactccgtt ggatgggccg 1560tcatcaccga cgagtacaag
gtgccctcca agaagttcaa ggtgttggga aacaccgaca 1620ggcacagcat
aaagaagaat ttgatcggtg ccctcctctt cgactccgga gagaccgctg
1680aggctaccag gctcaagagg accgctagaa ggcgctacac cagaaggaag
aacagaatct 1740gctacctgca ggagatcttc tccaacgaga tggccaaggt
ggacgactcc ttcttccacc 1800gccttgagga atcattcctg gtggaggagg
ataaaaagca cgagagacac ccaatcttcg 1860ggaacatcgt cgacgaggtg
gcctaccatg aaaagtaccc taccatctac cacctgagga 1920agaagctggt
cgactctacc gacaaggctg acttgcgctt gatttacctg gctctcgctc
1980acatgataaa gttccgcgga cacttcctca ttgagggaga cctgaaccca
gacaactccg 2040acgtggacaa gctcttcatc cagctcgttc agacctacaa
ccagcttttc gaggagaacc 2100caatcaacgc cagtggagtt gacgccaagg
ctatcctctc tgctcgtctg tcaaagtcca 2160ggaggcttga gaacttgatt
gcccagctgc ctggcgaaaa gaagaacgga ctgttcggaa 2220acttgatcgc
tctctccctg ggattgactc ccaacttcaa gtccaacttc gacctcgccg
2280aggacgctaa gttgcagttg tctaaagaca cctacgacga tgacctcgac
aacttgctgg 2340cccagatagg cgaccaatac gccgatctct tcctcgccgc
taagaacttg tccgacgcaa 2400tcctgctgtc cgacatcctg agagtcaaca
ctgagattac caaagctcct ctgtctgctt 2460ccatgattaa gcgctacgac
gagcaccacc aagatctgac cctgctcaag gccctggtga 2520gacagcagct
gcccgagaag tacaaggaga tctttttcga ccagtccaag aacggctacg
2580ccggatacat tgacggaggc gcctcccagg aagagttcta caagttcatc
aagcccatcc 2640ttgagaagat ggacggtacc gaggagctgt tggtgaagtt
gaacagagag gacctgttga 2700ggaagcagag aaccttcgac aacggaagca
tccctcacca aatccacctg ggagagctcc 2760acgccatctt gaggaggcag
gaggatttct atcccttcct gaaggacaac cgcgagaaga 2820ttgagaagat
cttgaccttc agaattcctt actacgtcgg gccactcgcc agaggaaact
2880ctaggttcgc ctggatgacc cgcaaatctg aagagaccat tactccctgg
aacttcgagg 2940aagtcgtgga caagggcgct tccgctcagt ctttcatcga
gaggatgacc aacttcgata 3000aaaatctgcc caacgagaag gtgctgccca
agcactccct gttgtacgag tatttcacag 3060tgtacaacga gctcaccaag
gtgaagtacg tcacagaggg aatgaggaag cctgccttct 3120tgtccggaga
gcagaagaag gccatcgtcg acctgctctt caagaccaac aggaaggtga
3180ctgtcaagca gctgaaggag gactacttca agaagatcga gtgcttcgac
tccgtcgaga 3240tctctggtgt cgaggacagg ttcaacgcct cccttgggac
ttaccacgat ctgctcaaga 3300ttattaaaga caaggacttc ctggacaacg
aggagaacga ggacatcctt gaggacatcg 3360tgctcaccct gaccttgttc
gaagacaggg aaatgatcga agagaggctc aagacctacg 3420cccacctctt
cgacgacaag gtgatgaaac agctgaagag acgcagatat accggctggg
3480gaaggctctc ccgcaaattg atcaacggga tcagggacaa gcagtcaggg
aagactatac 3540tcgacttcct gaagtccgac ggattcgcca acaggaactt
catgcagctc attcacgacg 3600actccttgac cttcaaggag gacatccaga
aggctcaggt gtctggacag ggtgactcct 3660tgcatgagca cattgctaac
ttggccggct ctcccgctat taagaagggc attttgcaga 3720ccgtgaaggt
cgttgacgag ctcgtgaagg tgatgggacg ccacaagcca gagaacatcg
3780ttattgagat ggctcgcgag aaccaaacta cccagaaagg gcagaagaat
tcccgcgaga 3840ggatgaagcg cattgaggag ggcataaaag agcttggctc
tcagatcctc aaggagcacc 3900ccgtcgagaa cactcagctg cagaacgaga
agctgtacct gtactacctc caaaacggaa 3960gggacatgta cgtggaccag
gagctggaca tcaacaggtt gtccgactac gacgtcgacc 4020acatcgtgcc
tcagtccttc ctgaaggatg actccatcga caataaagtg ctgacacgct
4080ccgataaaaa tagaggcaag tccgacaacg tcccctccga ggaggtcgtg
aagaagatga 4140aaaactactg gagacagctc ttgaacgcca agctcatcac
ccagcgtaag ttcgacaacc 4200tgactaaggc tgagagagga ggattgtccg
agctcgataa ggccggattc atcaagagac 4260agctcgtcga aacccgccaa
attaccaagc acgtggccca aattctggat tcccgcatga 4320acaccaagta
cgatgaaaat gacaagctga tccgcgaggt caaggtgatc accttgaagt
4380ccaagctggt ctccgacttc cgcaaggact tccagttcta caaggtgagg
gagatcaaca 4440actaccacca cgcacacgac gcctacctca acgctgtcgt
tggaaccgcc ctcatcaaaa 4500aatatcctaa gctggagtct gagttcgtct
acggcgacta caaggtgtac gacgtgagga 4560agatgatcgc taagtctgag
caggagatcg gcaaggccac cgccaagtac ttcttctact 4620ccaacatcat
gaacttcttc aagaccgaga tcactctcgc caacggtgag atcaggaagc
4680gcccactgat cgagaccaac ggtgagactg gagagatcgt gtgggacaaa
gggagggatt 4740tcgctactgt gaggaaggtg ctctccatgc ctcaggtgaa
catcgtcaag aagaccgaag 4800ttcagaccgg aggattctcc aaggagtcca
tcctccccaa gagaaactcc gacaagctga 4860tcgctagaaa gaaagactgg
gaccctaaga agtacggagg cttcgattct cctaccgtgg 4920cctactctgt
gctggtcgtg gccaaggtgg agaagggcaa gtccaagaag ctgaaatccg
4980tcaaggagct cctcgggatt accatcatgg agaggagttc cttcgagaag
aaccctatcg 5040acttcctgga ggccaaggga tataaagagg tgaagaagga
cctcatcatc aagctgccca 5100agtactccct cttcgagttg gagaacggaa
ggaagaggat gctggcttct gccggagagt 5160tgcagaaggg aaatgagctc
gcccttccct ccaagtacgt gaacttcctg tacctcgcct 5220ctcactatga
aaagttgaag ggctctcctg aggacaacga gcagaagcag ctcttcgtgg
5280agcagcacaa gcactacctg gacgaaatta tcgagcagat ctctgagttc
tccaagcgcg 5340tgatattggc cgacgccaac ctcgacaagg tgctgtccgc
ctacaacaag cacagggata 5400agcccattcg cgagcaggct gaaaacatta
tccacctgtt taccctcaca aacttgggag 5460cccctgctgc cttcaagtac
ttcgacacca ccattgacag gaagagatac acctccacca 5520aggaggtgct
cgacgcaaca ctcatccacc aatccatcac cggcctctat gaaacaagga
5580ttgacttgtc ccagctggga ggcgactcta gagccgatcc caagaagaag
agaaaggtgt 5640aggttaacct agacttgtcc atcttctgga ttggccaact
taattaatgt atgaaataaa 5700aggatgcaca catagtgaca tgctaatcac
tataatgtgg gcatcaaagt tgtgtgttat 5760gtgtaattac tagttatctg
aataaaagag aaagagatca tccatatttc ttatcctaaa 5820tgaatgtcac
gtgtctttat aattctttga tgaaccagat gcatttcatt aaccaaatcc
5880atatacatat aaatattaat catatataat taatatcaat tgggttagca
aaacaaatct 5940agtctaggtg tgttttgc 5958297573DNAArtificial
sequenceU6-9.1-DD20CR1 297ccgggttaag agaattgtaa gtgtgctttt
atatatttaa aattaatata ttttgaaatg 60ttaaaatata aaagaaaatt caatgtaaat
taaaaataaa taaatgttta ataaagataa 120attttaaaac ataaaagaaa
atgtctaaca agaggattaa gatcctgtgc tcttaaattt 180ttaggtgttg
aaatcttagc catacaaaat atattttatt aaaaccaagc atgaaaaaag
240tcactaaaga gctatataac tcatgcagct agaaatgaag tgaagggaat
ccagtttgtt 300ctcagtcgaa agagtgtcta tctttgttct tttctgcaac
cgagttaagc aaaatgggaa 360tgcgaggtat cttcctttcg ttaggggagc
accagatgca tagttagtcc cacattgatg 420aatataacaa gagcttcaca
gaatatatag cccaggccac agtaaaagct tggaactgac 480acacgacatg
agttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa
540cttgaaaaag tggcaccgag tcggtgcttt ttt 5732986611DNAArtificial
sequenceU6-9.1-DD20CR1+EF1A2-CAS9 298cgcgccggta cccgggttaa
gagaattgta agtgtgcttt tatatattta aaattaatat 60attttgaaat gttaaaatat
aaaagaaaat tcaatgtaaa ttaaaaataa ataaatgttt 120aataaagata
aattttaaaa cataaaagaa aatgtctaac aagaggatta agatcctgtg
180ctcttaaatt tttaggtgtt gaaatcttag ccatacaaaa tatattttat
taaaaccaag 240catgaaaaaa gtcactaaag agctatataa ctcatgcagc
tagaaatgaa gtgaagggaa 300tccagtttgt tctcagtcga aagagtgtct
atctttgttc ttttctgcaa ccgagttaag 360caaaatggga atgcgaggta
tcttcctttc gttaggggag caccagatgc atagttagtc 420ccacattgat
gaatataaca agagcttcac agaatatata gcccaggcca cagtaaaagc
480ttggaactga cacacgacat gagttttaga gctagaaata gcaagttaaa
ataaggctag 540tccgttatca acttgaaaaa gtggcaccga gtcggtgctt
ttttttgcgg ccgcaattgg 600atcgggttta cttattttgt gggtatctat
acttttatta gatttttaat caggctcctg 660atttcttttt atttcgattg
aattcctgaa cttgtattat tcagtagatc gaataaatta 720taaaaagata
aaatcataaa ataatatttt atcctatcaa tcatattaaa gcaatgaata
780tgtaaaatta atcttatctt tattttaaaa aatcatatag gtttagtatt
tttttaaaaa 840taaagatagg attagtttta ctattcactg cttattactt
ttaaaaaaat cataaaggtt 900tagtattttt ttaaaataaa tataggaata
gttttactat tcactgcttt aatagaaaaa 960tagtttaaaa tttaagatag
ttttaatccc agcatttgcc acgtttgaac gtgagccgaa 1020acgatgtcgt
tacattatct taacctagct gaaacgatgt cgtcataata tcgccaaatg
1080ccaactggac tacgtcgaac ccacaaatcc cacaaagcgc gtgaaatcaa
atcgctcaaa 1140ccacaaaaaa gaacaacgcg tttgttacac gctcaatccc
acgcgagtag agcacagtaa 1200ccttcaaata agcgaatggg gcataatcag
aaatccgaaa taaacctagg ggcattatcg 1260gaaatgaaaa gtagctcact
caatataaaa atctaggaac cctagttttc gttatcactc 1320tgtgctccct
cgctctattt ctcagtctct gtgtttgcgg ctgaggattc cgaacgagtg
1380accttcttcg tttctcgcaa aggtaacagc ctctgctctt gtctcttcga
ttcgatctat 1440gcctgtctct tatttacgat gatgtttctt cggttatgtt
tttttattta tgctttatgc 1500tgttgatgtt cggttgtttg tttcgctttg
tttttgtggt tcagtttttt aggattcttt 1560tggtttttga atcgattaat
cggaagagat tttcgagtta tttggtgtgt tggaggtgaa 1620tctttttttt
gaggtcatag atctgttgta tttgtgttat aaacatgcga ctttgtatga
1680ttttttacga ggttatgatg ttctggttgt tttattatga atctgttgag
acagaaccat 1740gatttttgtt gatgttcgtt tacactatta aaggtttgtt
ttaacaggat taaaagtttt 1800ttaagcatgt tgaaggagtc ttgtagatat
gtaaccgtcg atagtttttt tgtgggtttg 1860ttcacatgtt atcaagctta
atcttttact atgtatgcga ccatatctgg atccagcaaa 1920ggcgattttt
taattccttg tgaaactttt gtaatatgaa gttgaaattt tgttattggt
1980aaactataaa tgtgtgaagt tggagtatac ctttaccttc ttatttggct
ttgtgatagt 2040ttaatttata tgtattttga gttctgactt gtatttcttt
gaattgattc tagtttaagt 2100aatccatgga caaaaagtac tcaatagggc
tcgacatagg gactaactcc gttggatggg 2160ccgtcatcac cgacgagtac
aaggtgccct ccaagaagtt caaggtgttg ggaaacaccg 2220acaggcacag
cataaagaag aatttgatcg gtgccctcct cttcgactcc ggagagaccg
2280ctgaggctac caggctcaag aggaccgcta gaaggcgcta caccagaagg
aagaacagaa 2340tctgctacct gcaggagatc ttctccaacg agatggccaa
ggtggacgac tccttcttcc 2400accgccttga ggaatcattc ctggtggagg
aggataaaaa gcacgagaga cacccaatct 2460tcgggaacat cgtcgacgag
gtggcctacc atgaaaagta ccctaccatc taccacctga 2520ggaagaagct
ggtcgactct accgacaagg ctgacttgcg cttgatttac ctggctctcg
2580ctcacatgat aaagttccgc ggacacttcc tcattgaggg agacctgaac
ccagacaact 2640ccgacgtgga caagctcttc atccagctcg ttcagaccta
caaccagctt ttcgaggaga 2700acccaatcaa cgccagtgga gttgacgcca
aggctatcct ctctgctcgt ctgtcaaagt 2760ccaggaggct tgagaacttg
attgcccagc tgcctggcga aaagaagaac ggactgttcg 2820gaaacttgat
cgctctctcc ctgggattga ctcccaactt caagtccaac ttcgacctcg
2880ccgaggacgc taagttgcag ttgtctaaag acacctacga cgatgacctc
gacaacttgc 2940tggcccagat aggcgaccaa tacgccgatc tcttcctcgc
cgctaagaac ttgtccgacg 3000caatcctgct gtccgacatc ctgagagtca
acactgagat taccaaagct cctctgtctg 3060cttccatgat taagcgctac
gacgagcacc accaagatct gaccctgctc aaggccctgg 3120tgagacagca
gctgcccgag aagtacaagg agatcttttt cgaccagtcc aagaacggct
3180acgccggata cattgacgga ggcgcctccc aggaagagtt ctacaagttc
atcaagccca 3240tccttgagaa gatggacggt accgaggagc tgttggtgaa
gttgaacaga gaggacctgt 3300tgaggaagca gagaaccttc gacaacggaa
gcatccctca ccaaatccac ctgggagagc 3360tccacgccat cttgaggagg
caggaggatt tctatccctt cctgaaggac aaccgcgaga 3420agattgagaa
gatcttgacc ttcagaattc
cttactacgt cgggccactc gccagaggaa 3480actctaggtt cgcctggatg
acccgcaaat ctgaagagac cattactccc tggaacttcg 3540aggaagtcgt
ggacaagggc gcttccgctc agtctttcat cgagaggatg accaacttcg
3600ataaaaatct gcccaacgag aaggtgctgc ccaagcactc cctgttgtac
gagtatttca 3660cagtgtacaa cgagctcacc aaggtgaagt acgtcacaga
gggaatgagg aagcctgcct 3720tcttgtccgg agagcagaag aaggccatcg
tcgacctgct cttcaagacc aacaggaagg 3780tgactgtcaa gcagctgaag
gaggactact tcaagaagat cgagtgcttc gactccgtcg 3840agatctctgg
tgtcgaggac aggttcaacg cctcccttgg gacttaccac gatctgctca
3900agattattaa agacaaggac ttcctggaca acgaggagaa cgaggacatc
cttgaggaca 3960tcgtgctcac cctgaccttg ttcgaagaca gggaaatgat
cgaagagagg ctcaagacct 4020acgcccacct cttcgacgac aaggtgatga
aacagctgaa gagacgcaga tataccggct 4080ggggaaggct ctcccgcaaa
ttgatcaacg ggatcaggga caagcagtca gggaagacta 4140tactcgactt
cctgaagtcc gacggattcg ccaacaggaa cttcatgcag ctcattcacg
4200acgactcctt gaccttcaag gaggacatcc agaaggctca ggtgtctgga
cagggtgact 4260ccttgcatga gcacattgct aacttggccg gctctcccgc
tattaagaag ggcattttgc 4320agaccgtgaa ggtcgttgac gagctcgtga
aggtgatggg acgccacaag ccagagaaca 4380tcgttattga gatggctcgc
gagaaccaaa ctacccagaa agggcagaag aattcccgcg 4440agaggatgaa
gcgcattgag gagggcataa aagagcttgg ctctcagatc ctcaaggagc
4500accccgtcga gaacactcag ctgcagaacg agaagctgta cctgtactac
ctccaaaacg 4560gaagggacat gtacgtggac caggagctgg acatcaacag
gttgtccgac tacgacgtcg 4620accacatcgt gcctcagtcc ttcctgaagg
atgactccat cgacaataaa gtgctgacac 4680gctccgataa aaatagaggc
aagtccgaca acgtcccctc cgaggaggtc gtgaagaaga 4740tgaaaaacta
ctggagacag ctcttgaacg ccaagctcat cacccagcgt aagttcgaca
4800acctgactaa ggctgagaga ggaggattgt ccgagctcga taaggccgga
ttcatcaaga 4860gacagctcgt cgaaacccgc caaattacca agcacgtggc
ccaaattctg gattcccgca 4920tgaacaccaa gtacgatgaa aatgacaagc
tgatccgcga ggtcaaggtg atcaccttga 4980agtccaagct ggtctccgac
ttccgcaagg acttccagtt ctacaaggtg agggagatca 5040acaactacca
ccacgcacac gacgcctacc tcaacgctgt cgttggaacc gccctcatca
5100aaaaatatcc taagctggag tctgagttcg tctacggcga ctacaaggtg
tacgacgtga 5160ggaagatgat cgctaagtct gagcaggaga tcggcaaggc
caccgccaag tacttcttct 5220actccaacat catgaacttc ttcaagaccg
agatcactct cgccaacggt gagatcagga 5280agcgcccact gatcgagacc
aacggtgaga ctggagagat cgtgtgggac aaagggaggg 5340atttcgctac
tgtgaggaag gtgctctcca tgcctcaggt gaacatcgtc aagaagaccg
5400aagttcagac cggaggattc tccaaggagt ccatcctccc caagagaaac
tccgacaagc 5460tgatcgctag aaagaaagac tgggacccta agaagtacgg
aggcttcgat tctcctaccg 5520tggcctactc tgtgctggtc gtggccaagg
tggagaaggg caagtccaag aagctgaaat 5580ccgtcaagga gctcctcggg
attaccatca tggagaggag ttccttcgag aagaacccta 5640tcgacttcct
ggaggccaag ggatataaag aggtgaagaa ggacctcatc atcaagctgc
5700ccaagtactc cctcttcgag ttggagaacg gaaggaagag gatgctggct
tctgccggag 5760agttgcagaa gggaaatgag ctcgcccttc cctccaagta
cgtgaacttc ctgtacctcg 5820cctctcacta tgaaaagttg aagggctctc
ctgaggacaa cgagcagaag cagctcttcg 5880tggagcagca caagcactac
ctggacgaaa ttatcgagca gatctctgag ttctccaagc 5940gcgtgatatt
ggccgacgcc aacctcgaca aggtgctgtc cgcctacaac aagcacaggg
6000ataagcccat tcgcgagcag gctgaaaaca ttatccacct gtttaccctc
acaaacttgg 6060gagcccctgc tgccttcaag tacttcgaca ccaccattga
caggaagaga tacacctcca 6120ccaaggaggt gctcgacgca acactcatcc
accaatccat caccggcctc tatgaaacaa 6180ggattgactt gtcccagctg
ggaggcgact ctagagccga tcccaagaag aagagaaagg 6240tgtaggttaa
cctagacttg tccatcttct ggattggcca acttaattaa tgtatgaaat
6300aaaaggatgc acacatagtg acatgctaat cactataatg tgggcatcaa
agttgtgtgt 6360tatgtgtaat tactagttat ctgaataaaa gagaaagaga
tcatccatat ttcttatcct 6420aaatgaatgt cacgtgtctt tataattctt
tgatgaacca gatgcatttc attaaccaaa 6480tccatataca tataaatatt
aatcatatat aattaatatc aattgggtta gcaaaacaaa 6540tctagtctag
gtgtgttttg cgaattcgat atcaagctta tcgataccgt cgaggggggg
6600cccggtaccg g 66112995686DNAArtificial
sequenceDD20HR1-SAMSHPT-DD20HR2 299cgcgcctcta gttgaagaca cgttcatgtc
ttcatcgtaa gaagacactc agtagtcttc 60ggccagaatg gccatctgga ttcagcaggc
ctagaaggcc atttaaatcc tgaggatctg 120gtcttcctaa ggacccggga
tatcgctatc aactttgtat agaaaagttg ggccgaattc 180gagctcggta
cggccagaat ccggtaagtg actagggtca cgtgacccta gtcacttaaa
240ttcggccaga atggccatct ggattcagca ggcctagaag gcccggaccg
attaaacttt 300aattcggtcc gggttacctc gagcctagta ataattacac
atctaagata tccccttctt 360tttcaagtaa aataatatca tatgatctca
ttttagtgaa acaatactat ttccctgata 420actctcttca acattaggga
cttcatctaa tcatctactt tcaaggtata actagacgta 480tttgttcttt
taaaaaaaac actagatgta ctcgtcaact caaaattcat cgttcatgca
540ttttaattaa actttaatta gctaatgagt agaaaaagat catacgagta
aaatagaaga 600atcttcctag attttggaag aatggattgg agtgtaagtg
aattgatcca ttagtggaag 660atgctcttta caatggccaa actgttctaa
ttgttagagc acatttgaga tgaaacactt 720cagtagtgga ggtaacctac
aatcctagga tctgtatcct ctatcactaa tggagcaatg 780ggtttgagat
tgacttactc ctttccttgt ctctcgtagt gcatatgcgc actttcaaag
840gctacacaaa agccgttaac tttttgttta tttaagttac gaaagatagt
tgaattagag 900taaatggtga tattgaatta ggattttaaa taattttaaa
agaatttttt taataaaaaa 960aatattgtgt tgttggatca aaatttttaa
ataacatgaa taaggaaatg gattgcaatg 1020aggttttaaa caattatttt
aacatatagg attttagaaa gacttttata atattttgtt 1080gaagtttaga
ttttaatata tttatgtttt aaaattttaa aaaaaacttc atgaatttat
1140aatatttgaa aaagacacgt gaatatttag aaaacattta aaattacaat
aataaatcat 1200aatgagatag ggtgtattca tgtgtagacg agacaccaag
tatatggttc acaagtgaat 1260catctttttt ttttacagca caagtagatc
acttgtactt atcaaaattc ggaactgaca 1320cacactagtg gtcacctaag
tgactagggt cacgtgaccc tagtcactta ttcccaaaca 1380ctagtaacgg
ccgccagtgt gctggaattc gcccttccca agctttgctc tagatcaaac
1440tcacatccaa acataacatg gatatcttcc ttaccaatca tactaattat
tttgggttaa 1500atattaatca ttatttttaa gatattaatt aagaaattaa
aagatttttt aaaaaaatgt 1560ataaaattat attattcatg atttttcata
catttgattt tgataataaa tatatttttt 1620ttaatttctt aaaaaatgtt
gcaagacact tattagacat agtcttgttc tgtttacaaa 1680agcattcatc
atttaataca ttaaaaaata tttaatacta acagtagaat cttcttgtga
1740gtggtgtggg agtaggcaac ctggcattga aacgagagaa agagagtcag
aaccagaaga 1800caaataaaaa gtatgcaaca aacaaatcaa aatcaaaggg
caaaggctgg ggttggctca 1860attggttgct acattcaatt ttcaactcag
tcaacggttg agattcactc tgacttcccc 1920aatctaagcc gcggatgcaa
acggttgaat ctaacccaca atccaatctc gttacttagg 1980ggcttttccg
tcattaactc acccctgcca cccggtttcc ctataaattg gaactcaatg
2040ctcccctcta aactcgtatc gcttcagagt tgagaccaag acacactcgt
tcatatatct 2100ctctgctctt ctcttctctt ctacctctca aggtactttt
cttctccctc taccaaatcc 2160tagattccgt ggttcaattt cggatcttgc
acttctggtt tgctttgcct tgctttttcc 2220tcaactgggt ccatctagga
tccatgtgaa actctactct ttctttaata tctgcggaat 2280acgcgtttga
ctttcagatc tagtcgaaat catttcataa ttgcctttct ttcttttagc
2340ttatgagaaa taaaatcact ttttttttat ttcaaaataa accttgggcc
ttgtgctgac 2400tgagatgggg tttggtgatt acagaatttt agcgaatttt
gtaattgtac ttgtttgtct 2460gtagttttgt tttgttttct tgtttctcat
acattcctta ggcttcaatt ttattcgagt 2520ataggtcaca ataggaattc
aaactttgag caggggaatt aatcccttcc ttcaaatcca 2580gtttgtttgt
atatatgttt aaaaaatgaa acttttgctt taaattctat tataactttt
2640tttatggctg aaatttttgc atgtgtcttt gctctctgtt gtaaatttac
tgtttaggta 2700ctaactctag gcttgttgtg cagtttttga agtataacaa
cagaagttcc tattccgaag 2760ttcctattct ctagaaagta taggaacttc
cactagtcca tgaaaaagcc tgaactcacc 2820gcgacgtctg tcgagaagtt
tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 2880ctctcggagg
gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc
2940ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta
tcggcacttt 3000gcatcggccg cgctcccgat tccggaagtg cttgacattg
gggaattcag cgagagcctg 3060acctattgca tctcccgccg tgcacagggt
gtcacgttgc aagacctgcc tgaaaccgaa 3120ctgcccgctg ttctgcagcc
ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 3180agccagacga
gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg
3240cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac
tgtgatggac 3300gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc
tgatgctttg ggccgaggac 3360tgccccgaag tccggcacct cgtgcacgcg
gatttcggct ccaacaatgt cctgacggac 3420aatggccgca taacagcggt
cattgactgg agcgaggcga tgttcgggga ttcccaatac 3480gaggtcgcca
acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc
3540tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc
gtatatgctc 3600cgcattggtc ttgaccaact ctatcagagc ttggttgacg
gcaatttcga tgatgcagct 3660tgggcgcagg gtcgatgcga cgcaatcgtc
cgatccggag ccgggactgt cgggcgtaca 3720caaatcgccc gcagaagcgc
ggccgtctgg accgatggct gtgtagaagt actcgccgat 3780agtggaaacc
gacgccccag cactcgtccg agggcaaagg aatagtgagg tacctaaaga
3840aggagtgcgt cgaagcagat cgttcaaaca tttggcaata aagtttctta
agattgaatc 3900ctgttgccgg tcttgcgatg attatcatat aatttctgtt
gaattacgtt aagcatgtaa 3960taattaacat gtaatgcatg acgttattta
tgagatgggt ttttatgatt agagtcccgc 4020aattatacat ttaatacgcg
atagaaaaca aaatatagcg cgcaaactag gataaattat 4080cgcgcgcggt
gtcatctatg ttactagatc gatgtcgacc cgggccctag gaggccggcc
4140cagctgatga tcccggtgaa gttcctattc cgaagttcct attctccaga
aagtatagga 4200acttcactag agcttgcggc cgcgcatgct gacttaatca
gctaacgcca ctcgacctgc 4260aggcatgccc gcggatatcg atgggccccg
gccgaagctt caagtttgta caaaaaagca 4320ggctggcgcc ggaaccaatt
cagtcgactg gatccggtac cgaattcgcg gccgcactcg 4380agatatctag
acccagcttt cttgtacaaa gtggccgtta acggatcggc cagaatccgg
4440taagtgacta gggtcacgtg accctagtca cttaaattcg gccagaatgg
ccatctggat 4500tcagcaggcc tagaaggccc ggaccgatta aactttaatt
cggtccgggt tacctctaga 4560aagcttgtcg acctgcagac acgacatgat
ggaacgtgac taaggtgggt ttttgacttt 4620gcatgtcgaa gtgagagtga
ttttattgag agaataatag aagacctaca aaacaaatga 4680tcccgacgct
aaagtaagta cgagagttaa gagaataaat gggaaaatat gcatacatga
4740ttaggtgtgt gttcgtctca agaaagtacg aatgaatatg gtgtgtttgt
agtacatgaa 4800tgatgtgttt tgagggttca agggaaattg atatttatag
agtgaaatgg aaccagaggt 4860ctttgttgac aagggttgtt atgactcttg
caaataatta atagcttata aataatagcc 4920aataacttat tatagataga
gttagagata atatatagct aaatttgaac aaggcataca 4980aaacaaaaat
gctaaatatg aataagacaa tcaaaattgt agtcgatgtt caactctttg
5040tcgttgaaga acttgtttgc agtggtatag taaatgggtg tgagtgcagt
gtctcaccca 5100tctcacacca cacaaccaac ttcatatcta aagatattgt
cgctgaatac aaaattgagt 5160tatggaatat acaattcata atatagatac
gaaaaatcat ttcttacaaa acattcaatc 5220aaaaattatt caaacataat
tctagattaa gtaatccgaa gtacaagtta gtatcctaga 5280tccgttaatt
taaaattatg tttgcataat tttggatttg gtgttctata agggcacaat
5340tttgttcatt cttacaagtt tgtcaattct aaaatatatg caaatttgaa
gaaaaaaaat 5400ttacgaatgt gtctcaaaca ataacttaat gggaggagaa
tgagggatga agaagctcaa 5460aattaccaac gccttctacc tcaagaagct
acttcacaca aaatatgact ggcggaagga 5520taggggacaa ccgataacga
gaaggagata cataaggtaa tgtacgttgt tgtgtgaggg 5580atccggtcac
ctaagtgact agggtcacgt gaccctagtc acttattccc gggcaacttt
5640attatacaaa gttgatagat ctcgaattca ttccgattaa tcgtgg
56863006611DNAArtificial sequenceU6-9.1-DD20CR2+EF1A2-CAS9
300cgcgccggta cccgggttaa gagaattgta agtgtgcttt tatatattta
aaattaatat 60attttgaaat gttaaaatat aaaagaaaat tcaatgtaaa ttaaaaataa
ataaatgttt 120aataaagata aattttaaaa cataaaagaa aatgtctaac
aagaggatta agatcctgtg 180ctcttaaatt tttaggtgtt gaaatcttag
ccatacaaaa tatattttat taaaaccaag 240catgaaaaaa gtcactaaag
agctatataa ctcatgcagc tagaaatgaa gtgaagggaa 300tccagtttgt
tctcagtcga aagagtgtct atctttgttc ttttctgcaa ccgagttaag
360caaaatggga atgcgaggta tcttcctttc gttaggggag caccagatgc
atagttagtc 420ccacattgat gaatataaca agagcttcac agaatatata
gcccaggcca cagtaaaagc 480ttgacatgat ggaacgtgac tagttttaga
gctagaaata gcaagttaaa ataaggctag 540tccgttatca acttgaaaaa
gtggcaccga gtcggtgctt ttttttgcgg ccgcaattgg 600atcgggttta
cttattttgt gggtatctat acttttatta gatttttaat caggctcctg
660atttcttttt atttcgattg aattcctgaa cttgtattat tcagtagatc
gaataaatta 720taaaaagata aaatcataaa ataatatttt atcctatcaa
tcatattaaa gcaatgaata 780tgtaaaatta atcttatctt tattttaaaa
aatcatatag gtttagtatt tttttaaaaa 840taaagatagg attagtttta
ctattcactg cttattactt ttaaaaaaat cataaaggtt 900tagtattttt
ttaaaataaa tataggaata gttttactat tcactgcttt aatagaaaaa
960tagtttaaaa tttaagatag ttttaatccc agcatttgcc acgtttgaac
gtgagccgaa 1020acgatgtcgt tacattatct taacctagct gaaacgatgt
cgtcataata tcgccaaatg 1080ccaactggac tacgtcgaac ccacaaatcc
cacaaagcgc gtgaaatcaa atcgctcaaa 1140ccacaaaaaa gaacaacgcg
tttgttacac gctcaatccc acgcgagtag agcacagtaa 1200ccttcaaata
agcgaatggg gcataatcag aaatccgaaa taaacctagg ggcattatcg
1260gaaatgaaaa gtagctcact caatataaaa atctaggaac cctagttttc
gttatcactc 1320tgtgctccct cgctctattt ctcagtctct gtgtttgcgg
ctgaggattc cgaacgagtg 1380accttcttcg tttctcgcaa aggtaacagc
ctctgctctt gtctcttcga ttcgatctat 1440gcctgtctct tatttacgat
gatgtttctt cggttatgtt tttttattta tgctttatgc 1500tgttgatgtt
cggttgtttg tttcgctttg tttttgtggt tcagtttttt aggattcttt
1560tggtttttga atcgattaat cggaagagat tttcgagtta tttggtgtgt
tggaggtgaa 1620tctttttttt gaggtcatag atctgttgta tttgtgttat
aaacatgcga ctttgtatga 1680ttttttacga ggttatgatg ttctggttgt
tttattatga atctgttgag acagaaccat 1740gatttttgtt gatgttcgtt
tacactatta aaggtttgtt ttaacaggat taaaagtttt 1800ttaagcatgt
tgaaggagtc ttgtagatat gtaaccgtcg atagtttttt tgtgggtttg
1860ttcacatgtt atcaagctta atcttttact atgtatgcga ccatatctgg
atccagcaaa 1920ggcgattttt taattccttg tgaaactttt gtaatatgaa
gttgaaattt tgttattggt 1980aaactataaa tgtgtgaagt tggagtatac
ctttaccttc ttatttggct ttgtgatagt 2040ttaatttata tgtattttga
gttctgactt gtatttcttt gaattgattc tagtttaagt 2100aatccatgga
caaaaagtac tcaatagggc tcgacatagg gactaactcc gttggatggg
2160ccgtcatcac cgacgagtac aaggtgccct ccaagaagtt caaggtgttg
ggaaacaccg 2220acaggcacag cataaagaag aatttgatcg gtgccctcct
cttcgactcc ggagagaccg 2280ctgaggctac caggctcaag aggaccgcta
gaaggcgcta caccagaagg aagaacagaa 2340tctgctacct gcaggagatc
ttctccaacg agatggccaa ggtggacgac tccttcttcc 2400accgccttga
ggaatcattc ctggtggagg aggataaaaa gcacgagaga cacccaatct
2460tcgggaacat cgtcgacgag gtggcctacc atgaaaagta ccctaccatc
taccacctga 2520ggaagaagct ggtcgactct accgacaagg ctgacttgcg
cttgatttac ctggctctcg 2580ctcacatgat aaagttccgc ggacacttcc
tcattgaggg agacctgaac ccagacaact 2640ccgacgtgga caagctcttc
atccagctcg ttcagaccta caaccagctt ttcgaggaga 2700acccaatcaa
cgccagtgga gttgacgcca aggctatcct ctctgctcgt ctgtcaaagt
2760ccaggaggct tgagaacttg attgcccagc tgcctggcga aaagaagaac
ggactgttcg 2820gaaacttgat cgctctctcc ctgggattga ctcccaactt
caagtccaac ttcgacctcg 2880ccgaggacgc taagttgcag ttgtctaaag
acacctacga cgatgacctc gacaacttgc 2940tggcccagat aggcgaccaa
tacgccgatc tcttcctcgc cgctaagaac ttgtccgacg 3000caatcctgct
gtccgacatc ctgagagtca acactgagat taccaaagct cctctgtctg
3060cttccatgat taagcgctac gacgagcacc accaagatct gaccctgctc
aaggccctgg 3120tgagacagca gctgcccgag aagtacaagg agatcttttt
cgaccagtcc aagaacggct 3180acgccggata cattgacgga ggcgcctccc
aggaagagtt ctacaagttc atcaagccca 3240tccttgagaa gatggacggt
accgaggagc tgttggtgaa gttgaacaga gaggacctgt 3300tgaggaagca
gagaaccttc gacaacggaa gcatccctca ccaaatccac ctgggagagc
3360tccacgccat cttgaggagg caggaggatt tctatccctt cctgaaggac
aaccgcgaga 3420agattgagaa gatcttgacc ttcagaattc cttactacgt
cgggccactc gccagaggaa 3480actctaggtt cgcctggatg acccgcaaat
ctgaagagac cattactccc tggaacttcg 3540aggaagtcgt ggacaagggc
gcttccgctc agtctttcat cgagaggatg accaacttcg 3600ataaaaatct
gcccaacgag aaggtgctgc ccaagcactc cctgttgtac gagtatttca
3660cagtgtacaa cgagctcacc aaggtgaagt acgtcacaga gggaatgagg
aagcctgcct 3720tcttgtccgg agagcagaag aaggccatcg tcgacctgct
cttcaagacc aacaggaagg 3780tgactgtcaa gcagctgaag gaggactact
tcaagaagat cgagtgcttc gactccgtcg 3840agatctctgg tgtcgaggac
aggttcaacg cctcccttgg gacttaccac gatctgctca 3900agattattaa
agacaaggac ttcctggaca acgaggagaa cgaggacatc cttgaggaca
3960tcgtgctcac cctgaccttg ttcgaagaca gggaaatgat cgaagagagg
ctcaagacct 4020acgcccacct cttcgacgac aaggtgatga aacagctgaa
gagacgcaga tataccggct 4080ggggaaggct ctcccgcaaa ttgatcaacg
ggatcaggga caagcagtca gggaagacta 4140tactcgactt cctgaagtcc
gacggattcg ccaacaggaa cttcatgcag ctcattcacg 4200acgactcctt
gaccttcaag gaggacatcc agaaggctca ggtgtctgga cagggtgact
4260ccttgcatga gcacattgct aacttggccg gctctcccgc tattaagaag
ggcattttgc 4320agaccgtgaa ggtcgttgac gagctcgtga aggtgatggg
acgccacaag ccagagaaca 4380tcgttattga gatggctcgc gagaaccaaa
ctacccagaa agggcagaag aattcccgcg 4440agaggatgaa gcgcattgag
gagggcataa aagagcttgg ctctcagatc ctcaaggagc 4500accccgtcga
gaacactcag ctgcagaacg agaagctgta cctgtactac ctccaaaacg
4560gaagggacat gtacgtggac caggagctgg acatcaacag gttgtccgac
tacgacgtcg 4620accacatcgt gcctcagtcc ttcctgaagg atgactccat
cgacaataaa gtgctgacac 4680gctccgataa aaatagaggc aagtccgaca
acgtcccctc cgaggaggtc gtgaagaaga 4740tgaaaaacta ctggagacag
ctcttgaacg ccaagctcat cacccagcgt aagttcgaca 4800acctgactaa
ggctgagaga ggaggattgt ccgagctcga taaggccgga ttcatcaaga
4860gacagctcgt cgaaacccgc caaattacca agcacgtggc ccaaattctg
gattcccgca 4920tgaacaccaa gtacgatgaa aatgacaagc tgatccgcga
ggtcaaggtg atcaccttga 4980agtccaagct ggtctccgac ttccgcaagg
acttccagtt ctacaaggtg agggagatca 5040acaactacca ccacgcacac
gacgcctacc tcaacgctgt cgttggaacc gccctcatca 5100aaaaatatcc
taagctggag tctgagttcg tctacggcga ctacaaggtg tacgacgtga
5160ggaagatgat cgctaagtct gagcaggaga tcggcaaggc caccgccaag
tacttcttct 5220actccaacat catgaacttc ttcaagaccg agatcactct
cgccaacggt gagatcagga 5280agcgcccact gatcgagacc aacggtgaga
ctggagagat cgtgtgggac aaagggaggg 5340atttcgctac tgtgaggaag
gtgctctcca tgcctcaggt gaacatcgtc aagaagaccg 5400aagttcagac
cggaggattc tccaaggagt ccatcctccc caagagaaac tccgacaagc
5460tgatcgctag aaagaaagac tgggacccta agaagtacgg aggcttcgat
tctcctaccg 5520tggcctactc tgtgctggtc gtggccaagg tggagaaggg
caagtccaag aagctgaaat 5580ccgtcaagga gctcctcggg attaccatca
tggagaggag ttccttcgag aagaacccta 5640tcgacttcct ggaggccaag
ggatataaag aggtgaagaa ggacctcatc atcaagctgc 5700ccaagtactc
cctcttcgag ttggagaacg gaaggaagag gatgctggct tctgccggag
5760agttgcagaa gggaaatgag ctcgcccttc cctccaagta cgtgaacttc
ctgtacctcg 5820cctctcacta tgaaaagttg aagggctctc ctgaggacaa
cgagcagaag cagctcttcg 5880tggagcagca caagcactac ctggacgaaa
ttatcgagca gatctctgag ttctccaagc 5940gcgtgatatt ggccgacgcc
aacctcgaca aggtgctgtc cgcctacaac aagcacaggg 6000ataagcccat
tcgcgagcag gctgaaaaca
ttatccacct gtttaccctc acaaacttgg 6060gagcccctgc tgccttcaag
tacttcgaca ccaccattga caggaagaga tacacctcca 6120ccaaggaggt
gctcgacgca acactcatcc accaatccat caccggcctc tatgaaacaa
6180ggattgactt gtcccagctg ggaggcgact ctagagccga tcccaagaag
aagagaaagg 6240tgtaggttaa cctagacttg tccatcttct ggattggcca
acttaattaa tgtatgaaat 6300aaaaggatgc acacatagtg acatgctaat
cactataatg tgggcatcaa agttgtgtgt 6360tatgtgtaat tactagttat
ctgaataaaa gagaaagaga tcatccatat ttcttatcct 6420aaatgaatgt
cacgtgtctt tataattctt tgatgaacca gatgcatttc attaaccaaa
6480tccatataca tataaatatt aatcatatat aattaatatc aattgggtta
gcaaaacaaa 6540tctagtctag gtgtgttttg cgaattcgat atcaagctta
tcgataccgt cgaggggggg 6600cccggtaccg g 66113016611DNAArtificial
sequenceU6-9.1DD43CR1+EF1A2CAS9 301cgcgccggta cccgggttaa gagaattgta
agtgtgcttt tatatattta aaattaatat 60attttgaaat gttaaaatat aaaagaaaat
tcaatgtaaa ttaaaaataa ataaatgttt 120aataaagata aattttaaaa
cataaaagaa aatgtctaac aagaggatta agatcctgtg 180ctcttaaatt
tttaggtgtt gaaatcttag ccatacaaaa tatattttat taaaaccaag
240catgaaaaaa gtcactaaag agctatataa ctcatgcagc tagaaatgaa
gtgaagggaa 300tccagtttgt tctcagtcga aagagtgtct atctttgttc
ttttctgcaa ccgagttaag 360caaaatggga atgcgaggta tcttcctttc
gttaggggag caccagatgc atagttagtc 420ccacattgat gaatataaca
agagcttcac agaatatata gcccaggcca cagtaaaagc 480ttgtcccttg
tacttgtacg tagttttaga gctagaaata gcaagttaaa ataaggctag
540tccgttatca acttgaaaaa gtggcaccga gtcggtgctt ttttttgcgg
ccgcaattgg 600atcgggttta cttattttgt gggtatctat acttttatta
gatttttaat caggctcctg 660atttcttttt atttcgattg aattcctgaa
cttgtattat tcagtagatc gaataaatta 720taaaaagata aaatcataaa
ataatatttt atcctatcaa tcatattaaa gcaatgaata 780tgtaaaatta
atcttatctt tattttaaaa aatcatatag gtttagtatt tttttaaaaa
840taaagatagg attagtttta ctattcactg cttattactt ttaaaaaaat
cataaaggtt 900tagtattttt ttaaaataaa tataggaata gttttactat
tcactgcttt aatagaaaaa 960tagtttaaaa tttaagatag ttttaatccc
agcatttgcc acgtttgaac gtgagccgaa 1020acgatgtcgt tacattatct
taacctagct gaaacgatgt cgtcataata tcgccaaatg 1080ccaactggac
tacgtcgaac ccacaaatcc cacaaagcgc gtgaaatcaa atcgctcaaa
1140ccacaaaaaa gaacaacgcg tttgttacac gctcaatccc acgcgagtag
agcacagtaa 1200ccttcaaata agcgaatggg gcataatcag aaatccgaaa
taaacctagg ggcattatcg 1260gaaatgaaaa gtagctcact caatataaaa
atctaggaac cctagttttc gttatcactc 1320tgtgctccct cgctctattt
ctcagtctct gtgtttgcgg ctgaggattc cgaacgagtg 1380accttcttcg
tttctcgcaa aggtaacagc ctctgctctt gtctcttcga ttcgatctat
1440gcctgtctct tatttacgat gatgtttctt cggttatgtt tttttattta
tgctttatgc 1500tgttgatgtt cggttgtttg tttcgctttg tttttgtggt
tcagtttttt aggattcttt 1560tggtttttga atcgattaat cggaagagat
tttcgagtta tttggtgtgt tggaggtgaa 1620tctttttttt gaggtcatag
atctgttgta tttgtgttat aaacatgcga ctttgtatga 1680ttttttacga
ggttatgatg ttctggttgt tttattatga atctgttgag acagaaccat
1740gatttttgtt gatgttcgtt tacactatta aaggtttgtt ttaacaggat
taaaagtttt 1800ttaagcatgt tgaaggagtc ttgtagatat gtaaccgtcg
atagtttttt tgtgggtttg 1860ttcacatgtt atcaagctta atcttttact
atgtatgcga ccatatctgg atccagcaaa 1920ggcgattttt taattccttg
tgaaactttt gtaatatgaa gttgaaattt tgttattggt 1980aaactataaa
tgtgtgaagt tggagtatac ctttaccttc ttatttggct ttgtgatagt
2040ttaatttata tgtattttga gttctgactt gtatttcttt gaattgattc
tagtttaagt 2100aatccatgga caaaaagtac tcaatagggc tcgacatagg
gactaactcc gttggatggg 2160ccgtcatcac cgacgagtac aaggtgccct
ccaagaagtt caaggtgttg ggaaacaccg 2220acaggcacag cataaagaag
aatttgatcg gtgccctcct cttcgactcc ggagagaccg 2280ctgaggctac
caggctcaag aggaccgcta gaaggcgcta caccagaagg aagaacagaa
2340tctgctacct gcaggagatc ttctccaacg agatggccaa ggtggacgac
tccttcttcc 2400accgccttga ggaatcattc ctggtggagg aggataaaaa
gcacgagaga cacccaatct 2460tcgggaacat cgtcgacgag gtggcctacc
atgaaaagta ccctaccatc taccacctga 2520ggaagaagct ggtcgactct
accgacaagg ctgacttgcg cttgatttac ctggctctcg 2580ctcacatgat
aaagttccgc ggacacttcc tcattgaggg agacctgaac ccagacaact
2640ccgacgtgga caagctcttc atccagctcg ttcagaccta caaccagctt
ttcgaggaga 2700acccaatcaa cgccagtgga gttgacgcca aggctatcct
ctctgctcgt ctgtcaaagt 2760ccaggaggct tgagaacttg attgcccagc
tgcctggcga aaagaagaac ggactgttcg 2820gaaacttgat cgctctctcc
ctgggattga ctcccaactt caagtccaac ttcgacctcg 2880ccgaggacgc
taagttgcag ttgtctaaag acacctacga cgatgacctc gacaacttgc
2940tggcccagat aggcgaccaa tacgccgatc tcttcctcgc cgctaagaac
ttgtccgacg 3000caatcctgct gtccgacatc ctgagagtca acactgagat
taccaaagct cctctgtctg 3060cttccatgat taagcgctac gacgagcacc
accaagatct gaccctgctc aaggccctgg 3120tgagacagca gctgcccgag
aagtacaagg agatcttttt cgaccagtcc aagaacggct 3180acgccggata
cattgacgga ggcgcctccc aggaagagtt ctacaagttc atcaagccca
3240tccttgagaa gatggacggt accgaggagc tgttggtgaa gttgaacaga
gaggacctgt 3300tgaggaagca gagaaccttc gacaacggaa gcatccctca
ccaaatccac ctgggagagc 3360tccacgccat cttgaggagg caggaggatt
tctatccctt cctgaaggac aaccgcgaga 3420agattgagaa gatcttgacc
ttcagaattc cttactacgt cgggccactc gccagaggaa 3480actctaggtt
cgcctggatg acccgcaaat ctgaagagac cattactccc tggaacttcg
3540aggaagtcgt ggacaagggc gcttccgctc agtctttcat cgagaggatg
accaacttcg 3600ataaaaatct gcccaacgag aaggtgctgc ccaagcactc
cctgttgtac gagtatttca 3660cagtgtacaa cgagctcacc aaggtgaagt
acgtcacaga gggaatgagg aagcctgcct 3720tcttgtccgg agagcagaag
aaggccatcg tcgacctgct cttcaagacc aacaggaagg 3780tgactgtcaa
gcagctgaag gaggactact tcaagaagat cgagtgcttc gactccgtcg
3840agatctctgg tgtcgaggac aggttcaacg cctcccttgg gacttaccac
gatctgctca 3900agattattaa agacaaggac ttcctggaca acgaggagaa
cgaggacatc cttgaggaca 3960tcgtgctcac cctgaccttg ttcgaagaca
gggaaatgat cgaagagagg ctcaagacct 4020acgcccacct cttcgacgac
aaggtgatga aacagctgaa gagacgcaga tataccggct 4080ggggaaggct
ctcccgcaaa ttgatcaacg ggatcaggga caagcagtca gggaagacta
4140tactcgactt cctgaagtcc gacggattcg ccaacaggaa cttcatgcag
ctcattcacg 4200acgactcctt gaccttcaag gaggacatcc agaaggctca
ggtgtctgga cagggtgact 4260ccttgcatga gcacattgct aacttggccg
gctctcccgc tattaagaag ggcattttgc 4320agaccgtgaa ggtcgttgac
gagctcgtga aggtgatggg acgccacaag ccagagaaca 4380tcgttattga
gatggctcgc gagaaccaaa ctacccagaa agggcagaag aattcccgcg
4440agaggatgaa gcgcattgag gagggcataa aagagcttgg ctctcagatc
ctcaaggagc 4500accccgtcga gaacactcag ctgcagaacg agaagctgta
cctgtactac ctccaaaacg 4560gaagggacat gtacgtggac caggagctgg
acatcaacag gttgtccgac tacgacgtcg 4620accacatcgt gcctcagtcc
ttcctgaagg atgactccat cgacaataaa gtgctgacac 4680gctccgataa
aaatagaggc aagtccgaca acgtcccctc cgaggaggtc gtgaagaaga
4740tgaaaaacta ctggagacag ctcttgaacg ccaagctcat cacccagcgt
aagttcgaca 4800acctgactaa ggctgagaga ggaggattgt ccgagctcga
taaggccgga ttcatcaaga 4860gacagctcgt cgaaacccgc caaattacca
agcacgtggc ccaaattctg gattcccgca 4920tgaacaccaa gtacgatgaa
aatgacaagc tgatccgcga ggtcaaggtg atcaccttga 4980agtccaagct
ggtctccgac ttccgcaagg acttccagtt ctacaaggtg agggagatca
5040acaactacca ccacgcacac gacgcctacc tcaacgctgt cgttggaacc
gccctcatca 5100aaaaatatcc taagctggag tctgagttcg tctacggcga
ctacaaggtg tacgacgtga 5160ggaagatgat cgctaagtct gagcaggaga
tcggcaaggc caccgccaag tacttcttct 5220actccaacat catgaacttc
ttcaagaccg agatcactct cgccaacggt gagatcagga 5280agcgcccact
gatcgagacc aacggtgaga ctggagagat cgtgtgggac aaagggaggg
5340atttcgctac tgtgaggaag gtgctctcca tgcctcaggt gaacatcgtc
aagaagaccg 5400aagttcagac cggaggattc tccaaggagt ccatcctccc
caagagaaac tccgacaagc 5460tgatcgctag aaagaaagac tgggacccta
agaagtacgg aggcttcgat tctcctaccg 5520tggcctactc tgtgctggtc
gtggccaagg tggagaaggg caagtccaag aagctgaaat 5580ccgtcaagga
gctcctcggg attaccatca tggagaggag ttccttcgag aagaacccta
5640tcgacttcct ggaggccaag ggatataaag aggtgaagaa ggacctcatc
atcaagctgc 5700ccaagtactc cctcttcgag ttggagaacg gaaggaagag
gatgctggct tctgccggag 5760agttgcagaa gggaaatgag ctcgcccttc
cctccaagta cgtgaacttc ctgtacctcg 5820cctctcacta tgaaaagttg
aagggctctc ctgaggacaa cgagcagaag cagctcttcg 5880tggagcagca
caagcactac ctggacgaaa ttatcgagca gatctctgag ttctccaagc
5940gcgtgatatt ggccgacgcc aacctcgaca aggtgctgtc cgcctacaac
aagcacaggg 6000ataagcccat tcgcgagcag gctgaaaaca ttatccacct
gtttaccctc acaaacttgg 6060gagcccctgc tgccttcaag tacttcgaca
ccaccattga caggaagaga tacacctcca 6120ccaaggaggt gctcgacgca
acactcatcc accaatccat caccggcctc tatgaaacaa 6180ggattgactt
gtcccagctg ggaggcgact ctagagccga tcccaagaag aagagaaagg
6240tgtaggttaa cctagacttg tccatcttct ggattggcca acttaattaa
tgtatgaaat 6300aaaaggatgc acacatagtg acatgctaat cactataatg
tgggcatcaa agttgtgtgt 6360tatgtgtaat tactagttat ctgaataaaa
gagaaagaga tcatccatat ttcttatcct 6420aaatgaatgt cacgtgtctt
tataattctt tgatgaacca gatgcatttc attaaccaaa 6480tccatataca
tataaatatt aatcatatat aattaatatc aattgggtta gcaaaacaaa
6540tctagtctag gtgtgttttg cgaattcgat atcaagctta tcgataccgt
cgaggggggg 6600cccggtaccg g 66113025719DNAArtificial
sequenceDD43HR1-SAMSHPT-DD43HR2 302cgcgcctcta gttgaagaca cgttcatgtc
ttcatcgtaa gaagacactc agtagtcttc 60ggccagaatg gccatctgga ttcagcaggc
ctagaaggcc atttaaatcc tgaggatctg 120gtcttcctaa ggacccggga
tatcgctatc aactttgtat agaaaagttg ggccgaattc 180gagctcggta
cggccagaat ccggtaagtg actagggtca cgtgacccta gtcacttaaa
240ttcggccaga atggccatct ggattcagca ggcctagaag gcccggaccg
attaaacttt 300aattcggtcc gggttacctc gagatcttgt tcccctcctt
ggtttggcat aaattgattt 360tcatggctct tctcggtcga aactggagct
aattcaccct tagtctctct taaaattctg 420gctgtaagaa acaccacaga
acacataaat tataaactaa ttataatttg aagagtaaaa 480tatgttttta
ctcttatgat ttaattagtg tagttttaat tttctccttt ttttaaaaaa
540ttttggtatt cataaatttc aattttttaa aaataattgt tgttacccgt
taatgataac 600gggatatgtt atgttaccac taaatcggac aaaaaaaatt
caaaactttt ataaggatta 660aaattaacaa aaatatttta aaaaaatcta
acctcaataa agttaaattt ataagcacaa 720aataatactt ttaagcctaa
tttggcaaga cacaagcaag ctcacctgta gcattaatag 780aaaggaagca
aagcaagaga aaagcaacca gaaggaagcg tttgcttggt gacacagcca
840tcttacttga atttatggta ttactgagaa accttgatct tgcttcaaaa
tcttctagtt 900accctctttt tataggcaga aagagaacta gctagttgcc
aataggatat gaggacatgt 960ggtgcaatgc actcactctt caaggacaag
aaaaacaatg gctacaattg tggttcaaat 1020caatgtctcc tgctctgtcc
tgcctgaaaa tgacaccctt ttgcttggaa aagaggatca 1080aagctaagaa
caggagtggc ttcattccct tcatgtaacc aaacactttc gcattctgtc
1140attcgtgaat cagcaaaatc tgcaaccaaa aatatatggt gcctaaataa
aagaaataaa 1200ataatttaga gttgcggact aaaataataa acaaaagaaa
tatattataa tctagaatta 1260atttaggact aaaagaagag gcagactcca
attcctcttt tctagaatac cctccgtacg 1320tacactagtg gtcacctaag
tgactagggt cacgtgaccc tagtcactta ttcccaaaca 1380ctagtaacgg
ccgccagtgt gctggaattc gcccttccca agctttgctc tagatcaaac
1440tcacatccaa acataacatg gatatcttcc ttaccaatca tactaattat
tttgggttaa 1500atattaatca ttatttttaa gatattaatt aagaaattaa
aagatttttt aaaaaaatgt 1560ataaaattat attattcatg atttttcata
catttgattt tgataataaa tatatttttt 1620ttaatttctt aaaaaatgtt
gcaagacact tattagacat agtcttgttc tgtttacaaa 1680agcattcatc
atttaataca ttaaaaaata tttaatacta acagtagaat cttcttgtga
1740gtggtgtggg agtaggcaac ctggcattga aacgagagaa agagagtcag
aaccagaaga 1800caaataaaaa gtatgcaaca aacaaatcaa aatcaaaggg
caaaggctgg ggttggctca 1860attggttgct acattcaatt ttcaactcag
tcaacggttg agattcactc tgacttcccc 1920aatctaagcc gcggatgcaa
acggttgaat ctaacccaca atccaatctc gttacttagg 1980ggcttttccg
tcattaactc acccctgcca cccggtttcc ctataaattg gaactcaatg
2040ctcccctcta aactcgtatc gcttcagagt tgagaccaag acacactcgt
tcatatatct 2100ctctgctctt ctcttctctt ctacctctca aggtactttt
cttctccctc taccaaatcc 2160tagattccgt ggttcaattt cggatcttgc
acttctggtt tgctttgcct tgctttttcc 2220tcaactgggt ccatctagga
tccatgtgaa actctactct ttctttaata tctgcggaat 2280acgcgtttga
ctttcagatc tagtcgaaat catttcataa ttgcctttct ttcttttagc
2340ttatgagaaa taaaatcact ttttttttat ttcaaaataa accttgggcc
ttgtgctgac 2400tgagatgggg tttggtgatt acagaatttt agcgaatttt
gtaattgtac ttgtttgtct 2460gtagttttgt tttgttttct tgtttctcat
acattcctta ggcttcaatt ttattcgagt 2520ataggtcaca ataggaattc
aaactttgag caggggaatt aatcccttcc ttcaaatcca 2580gtttgtttgt
atatatgttt aaaaaatgaa acttttgctt taaattctat tataactttt
2640tttatggctg aaatttttgc atgtgtcttt gctctctgtt gtaaatttac
tgtttaggta 2700ctaactctag gcttgttgtg cagtttttga agtataacaa
cagaagttcc tattccgaag 2760ttcctattct ctagaaagta taggaacttc
cactagtcca tgaaaaagcc tgaactcacc 2820gcgacgtctg tcgagaagtt
tctgatcgaa aagttcgaca gcgtctccga cctgatgcag 2880ctctcggagg
gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc
2940ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta
tcggcacttt 3000gcatcggccg cgctcccgat tccggaagtg cttgacattg
gggaattcag cgagagcctg 3060acctattgca tctcccgccg tgcacagggt
gtcacgttgc aagacctgcc tgaaaccgaa 3120ctgcccgctg ttctgcagcc
ggtcgcggag gccatggatg cgatcgctgc ggccgatctt 3180agccagacga
gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg
3240cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac
tgtgatggac 3300gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc
tgatgctttg ggccgaggac 3360tgccccgaag tccggcacct cgtgcacgcg
gatttcggct ccaacaatgt cctgacggac 3420aatggccgca taacagcggt
cattgactgg agcgaggcga tgttcgggga ttcccaatac 3480gaggtcgcca
acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc
3540tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc
gtatatgctc 3600cgcattggtc ttgaccaact ctatcagagc ttggttgacg
gcaatttcga tgatgcagct 3660tgggcgcagg gtcgatgcga cgcaatcgtc
cgatccggag ccgggactgt cgggcgtaca 3720caaatcgccc gcagaagcgc
ggccgtctgg accgatggct gtgtagaagt actcgccgat 3780agtggaaacc
gacgccccag cactcgtccg agggcaaagg aatagtgagg tacctaaaga
3840aggagtgcgt cgaagcagat cgttcaaaca tttggcaata aagtttctta
agattgaatc 3900ctgttgccgg tcttgcgatg attatcatat aatttctgtt
gaattacgtt aagcatgtaa 3960taattaacat gtaatgcatg acgttattta
tgagatgggt ttttatgatt agagtcccgc 4020aattatacat ttaatacgcg
atagaaaaca aaatatagcg cgcaaactag gataaattat 4080cgcgcgcggt
gtcatctatg ttactagatc gatgtcgacc cgggccctag gaggccggcc
4140cagctgatga tcccggtgaa gttcctattc cgaagttcct attctccaga
aagtatagga 4200acttcactag agcttgcggc cgcgcatgct gacttaatca
gctaacgcca ctcgacctgc 4260aggcatgccc gcggatatcg atgggccccg
gccgaagctt caagtttgta caaaaaagca 4320ggctggcgcc ggaaccaatt
cagtcgactg gatccggtac cgaattcgcg gccgcactcg 4380agatatctag
acccagcttt cttgtacaaa gtggccgtta acggatcggc cagaatccgg
4440taagtgacta gggtcacgtg accctagtca cttaaattcg gccagaatgg
ccatctggat 4500tcagcaggcc tagaaggccc ggaccgatta aactttaatt
cggtccgggt tacctctaga 4560aagcttgtcg acctgcaggt acaagtacaa
gggacttgtg agttgtaagg ctgtatttac 4620aatagtgaaa agagaatcat
ctgggtgatt gggtttttag tccccagtga cgaattaaag 4680gtttgaattc
ttagtatgtt tgggaatcaa ttaggaattt cgttttggac tttccaaagc
4740aattattcac tttttcattc attaaatgtg actaaaaaat tgttatttct
ccattggcca 4800ggatgcatcg tttatataaa cataacctta gtgaaagcag
tgttttcatg tgacagcggc 4860agactatatc ttaaacaaaa ttacttgtaa
agaaagatac cgttaggaaa aaaatgaaaa 4920gaaaattgaa gctatcactt
gtttactttc ctaatatctt tcaagaatac aatgtggtga 4980atttcaattt
tccctacata tgtataccgt cagcctgacg caacttatga aacttctctt
5040tctttcattt gatgtatata taaagacaca ttatatataa agaaacttta
tatatatctc 5100catcatattt tagtacttgc tactatgtaa aattagctgt
tggaagtatc tcaagaaaca 5160tttaatttat tgaaccaagc attaaccatt
catctacatt tgagttctaa aataaatctt 5220aaatgatgtg gaggaaggga
aattgttaat tatttccctc ttctcctaca tggatatacc 5280tgaaacatgc
aatggatgga ttagatttta acatttgcag cctgagaagt tcactgactt
5340tcctccagct attttatgtg tgcccgccac catttatagc tcatgattgt
agctgaactg 5400caaaaactgc atcgattgca aactgaaatt gagaatctct
tttcaacttt atatgctgat 5460tgatgcatgc tgagcatgct atactagtac
tcgaagttcc tatatgtaga ctttgttact 5520gcctaatata ctttgtgttt
gttctcaagt tcttatttta tttcatattt tttcctataa 5580aaggttaatg
gctctataaa ggttgagtga cggatccggt cacctaagtg actagggtca
5640cgtgacccta gtcacttatt cccgggcaac tttattatac aaagttgata
gatctcgaat 5700tcattccgat taatcgtgg 57193036611DNAArtificial
sequenceU6-9.1DD43CR2+EF1A2CAS9 303cgcgccggta cccgggttaa gagaattgta
agtgtgcttt tatatattta aaattaatat 60attttgaaat gttaaaatat aaaagaaaat
tcaatgtaaa ttaaaaataa ataaatgttt 120aataaagata aattttaaaa
cataaaagaa aatgtctaac aagaggatta agatcctgtg 180ctcttaaatt
tttaggtgtt gaaatcttag ccatacaaaa tatattttat taaaaccaag
240catgaaaaaa gtcactaaag agctatataa ctcatgcagc tagaaatgaa
gtgaagggaa 300tccagtttgt tctcagtcga aagagtgtct atctttgttc
ttttctgcaa ccgagttaag 360caaaatggga atgcgaggta tcttcctttc
gttaggggag caccagatgc atagttagtc 420ccacattgat gaatataaca
agagcttcac agaatatata gcccaggcca cagtaaaagc 480ttgtattcta
gaaaagagga atgttttaga gctagaaata gcaagttaaa ataaggctag
540tccgttatca acttgaaaaa gtggcaccga gtcggtgctt ttttttgcgg
ccgcaattgg 600atcgggttta cttattttgt gggtatctat acttttatta
gatttttaat caggctcctg 660atttcttttt atttcgattg aattcctgaa
cttgtattat tcagtagatc gaataaatta 720taaaaagata aaatcataaa
ataatatttt atcctatcaa tcatattaaa gcaatgaata 780tgtaaaatta
atcttatctt tattttaaaa aatcatatag gtttagtatt tttttaaaaa
840taaagatagg attagtttta ctattcactg cttattactt ttaaaaaaat
cataaaggtt 900tagtattttt ttaaaataaa tataggaata gttttactat
tcactgcttt aatagaaaaa 960tagtttaaaa tttaagatag ttttaatccc
agcatttgcc acgtttgaac gtgagccgaa 1020acgatgtcgt tacattatct
taacctagct gaaacgatgt cgtcataata tcgccaaatg 1080ccaactggac
tacgtcgaac ccacaaatcc cacaaagcgc gtgaaatcaa atcgctcaaa
1140ccacaaaaaa gaacaacgcg tttgttacac gctcaatccc acgcgagtag
agcacagtaa 1200ccttcaaata agcgaatggg gcataatcag aaatccgaaa
taaacctagg ggcattatcg 1260gaaatgaaaa gtagctcact caatataaaa
atctaggaac cctagttttc gttatcactc 1320tgtgctccct cgctctattt
ctcagtctct gtgtttgcgg ctgaggattc cgaacgagtg 1380accttcttcg
tttctcgcaa aggtaacagc ctctgctctt gtctcttcga ttcgatctat
1440gcctgtctct tatttacgat gatgtttctt cggttatgtt tttttattta
tgctttatgc 1500tgttgatgtt cggttgtttg tttcgctttg tttttgtggt
tcagtttttt aggattcttt 1560tggtttttga atcgattaat cggaagagat
tttcgagtta tttggtgtgt tggaggtgaa 1620tctttttttt gaggtcatag
atctgttgta tttgtgttat aaacatgcga ctttgtatga 1680ttttttacga
ggttatgatg ttctggttgt tttattatga atctgttgag acagaaccat
1740gatttttgtt gatgttcgtt tacactatta aaggtttgtt ttaacaggat
taaaagtttt 1800ttaagcatgt tgaaggagtc ttgtagatat
gtaaccgtcg atagtttttt tgtgggtttg 1860ttcacatgtt atcaagctta
atcttttact atgtatgcga ccatatctgg atccagcaaa 1920ggcgattttt
taattccttg tgaaactttt gtaatatgaa gttgaaattt tgttattggt
1980aaactataaa tgtgtgaagt tggagtatac ctttaccttc ttatttggct
ttgtgatagt 2040ttaatttata tgtattttga gttctgactt gtatttcttt
gaattgattc tagtttaagt 2100aatccatgga caaaaagtac tcaatagggc
tcgacatagg gactaactcc gttggatggg 2160ccgtcatcac cgacgagtac
aaggtgccct ccaagaagtt caaggtgttg ggaaacaccg 2220acaggcacag
cataaagaag aatttgatcg gtgccctcct cttcgactcc ggagagaccg
2280ctgaggctac caggctcaag aggaccgcta gaaggcgcta caccagaagg
aagaacagaa 2340tctgctacct gcaggagatc ttctccaacg agatggccaa
ggtggacgac tccttcttcc 2400accgccttga ggaatcattc ctggtggagg
aggataaaaa gcacgagaga cacccaatct 2460tcgggaacat cgtcgacgag
gtggcctacc atgaaaagta ccctaccatc taccacctga 2520ggaagaagct
ggtcgactct accgacaagg ctgacttgcg cttgatttac ctggctctcg
2580ctcacatgat aaagttccgc ggacacttcc tcattgaggg agacctgaac
ccagacaact 2640ccgacgtgga caagctcttc atccagctcg ttcagaccta
caaccagctt ttcgaggaga 2700acccaatcaa cgccagtgga gttgacgcca
aggctatcct ctctgctcgt ctgtcaaagt 2760ccaggaggct tgagaacttg
attgcccagc tgcctggcga aaagaagaac ggactgttcg 2820gaaacttgat
cgctctctcc ctgggattga ctcccaactt caagtccaac ttcgacctcg
2880ccgaggacgc taagttgcag ttgtctaaag acacctacga cgatgacctc
gacaacttgc 2940tggcccagat aggcgaccaa tacgccgatc tcttcctcgc
cgctaagaac ttgtccgacg 3000caatcctgct gtccgacatc ctgagagtca
acactgagat taccaaagct cctctgtctg 3060cttccatgat taagcgctac
gacgagcacc accaagatct gaccctgctc aaggccctgg 3120tgagacagca
gctgcccgag aagtacaagg agatcttttt cgaccagtcc aagaacggct
3180acgccggata cattgacgga ggcgcctccc aggaagagtt ctacaagttc
atcaagccca 3240tccttgagaa gatggacggt accgaggagc tgttggtgaa
gttgaacaga gaggacctgt 3300tgaggaagca gagaaccttc gacaacggaa
gcatccctca ccaaatccac ctgggagagc 3360tccacgccat cttgaggagg
caggaggatt tctatccctt cctgaaggac aaccgcgaga 3420agattgagaa
gatcttgacc ttcagaattc cttactacgt cgggccactc gccagaggaa
3480actctaggtt cgcctggatg acccgcaaat ctgaagagac cattactccc
tggaacttcg 3540aggaagtcgt ggacaagggc gcttccgctc agtctttcat
cgagaggatg accaacttcg 3600ataaaaatct gcccaacgag aaggtgctgc
ccaagcactc cctgttgtac gagtatttca 3660cagtgtacaa cgagctcacc
aaggtgaagt acgtcacaga gggaatgagg aagcctgcct 3720tcttgtccgg
agagcagaag aaggccatcg tcgacctgct cttcaagacc aacaggaagg
3780tgactgtcaa gcagctgaag gaggactact tcaagaagat cgagtgcttc
gactccgtcg 3840agatctctgg tgtcgaggac aggttcaacg cctcccttgg
gacttaccac gatctgctca 3900agattattaa agacaaggac ttcctggaca
acgaggagaa cgaggacatc cttgaggaca 3960tcgtgctcac cctgaccttg
ttcgaagaca gggaaatgat cgaagagagg ctcaagacct 4020acgcccacct
cttcgacgac aaggtgatga aacagctgaa gagacgcaga tataccggct
4080ggggaaggct ctcccgcaaa ttgatcaacg ggatcaggga caagcagtca
gggaagacta 4140tactcgactt cctgaagtcc gacggattcg ccaacaggaa
cttcatgcag ctcattcacg 4200acgactcctt gaccttcaag gaggacatcc
agaaggctca ggtgtctgga cagggtgact 4260ccttgcatga gcacattgct
aacttggccg gctctcccgc tattaagaag ggcattttgc 4320agaccgtgaa
ggtcgttgac gagctcgtga aggtgatggg acgccacaag ccagagaaca
4380tcgttattga gatggctcgc gagaaccaaa ctacccagaa agggcagaag
aattcccgcg 4440agaggatgaa gcgcattgag gagggcataa aagagcttgg
ctctcagatc ctcaaggagc 4500accccgtcga gaacactcag ctgcagaacg
agaagctgta cctgtactac ctccaaaacg 4560gaagggacat gtacgtggac
caggagctgg acatcaacag gttgtccgac tacgacgtcg 4620accacatcgt
gcctcagtcc ttcctgaagg atgactccat cgacaataaa gtgctgacac
4680gctccgataa aaatagaggc aagtccgaca acgtcccctc cgaggaggtc
gtgaagaaga 4740tgaaaaacta ctggagacag ctcttgaacg ccaagctcat
cacccagcgt aagttcgaca 4800acctgactaa ggctgagaga ggaggattgt
ccgagctcga taaggccgga ttcatcaaga 4860gacagctcgt cgaaacccgc
caaattacca agcacgtggc ccaaattctg gattcccgca 4920tgaacaccaa
gtacgatgaa aatgacaagc tgatccgcga ggtcaaggtg atcaccttga
4980agtccaagct ggtctccgac ttccgcaagg acttccagtt ctacaaggtg
agggagatca 5040acaactacca ccacgcacac gacgcctacc tcaacgctgt
cgttggaacc gccctcatca 5100aaaaatatcc taagctggag tctgagttcg
tctacggcga ctacaaggtg tacgacgtga 5160ggaagatgat cgctaagtct
gagcaggaga tcggcaaggc caccgccaag tacttcttct 5220actccaacat
catgaacttc ttcaagaccg agatcactct cgccaacggt gagatcagga
5280agcgcccact gatcgagacc aacggtgaga ctggagagat cgtgtgggac
aaagggaggg 5340atttcgctac tgtgaggaag gtgctctcca tgcctcaggt
gaacatcgtc aagaagaccg 5400aagttcagac cggaggattc tccaaggagt
ccatcctccc caagagaaac tccgacaagc 5460tgatcgctag aaagaaagac
tgggacccta agaagtacgg aggcttcgat tctcctaccg 5520tggcctactc
tgtgctggtc gtggccaagg tggagaaggg caagtccaag aagctgaaat
5580ccgtcaagga gctcctcggg attaccatca tggagaggag ttccttcgag
aagaacccta 5640tcgacttcct ggaggccaag ggatataaag aggtgaagaa
ggacctcatc atcaagctgc 5700ccaagtactc cctcttcgag ttggagaacg
gaaggaagag gatgctggct tctgccggag 5760agttgcagaa gggaaatgag
ctcgcccttc cctccaagta cgtgaacttc ctgtacctcg 5820cctctcacta
tgaaaagttg aagggctctc ctgaggacaa cgagcagaag cagctcttcg
5880tggagcagca caagcactac ctggacgaaa ttatcgagca gatctctgag
ttctccaagc 5940gcgtgatatt ggccgacgcc aacctcgaca aggtgctgtc
cgcctacaac aagcacaggg 6000ataagcccat tcgcgagcag gctgaaaaca
ttatccacct gtttaccctc acaaacttgg 6060gagcccctgc tgccttcaag
tacttcgaca ccaccattga caggaagaga tacacctcca 6120ccaaggaggt
gctcgacgca acactcatcc accaatccat caccggcctc tatgaaacaa
6180ggattgactt gtcccagctg ggaggcgact ctagagccga tcccaagaag
aagagaaagg 6240tgtaggttaa cctagacttg tccatcttct ggattggcca
acttaattaa tgtatgaaat 6300aaaaggatgc acacatagtg acatgctaat
cactataatg tgggcatcaa agttgtgtgt 6360tatgtgtaat tactagttat
ctgaataaaa gagaaagaga tcatccatat ttcttatcct 6420aaatgaatgt
cacgtgtctt tataattctt tgatgaacca gatgcatttc attaaccaaa
6480tccatataca tataaatatt aatcatatat aattaatatc aattgggtta
gcaaaacaaa 6540tctagtctag gtgtgttttg cgaattcgat atcaagctta
tcgataccgt cgaggggggg 6600cccggtaccg g 661130464DNAArtificial
sequenceDD20 qPCR amplicon 304attcggaact gacacacgac atgatggaac
gtgactaagg tgggtttttg actttgcatg 60tcga 64305115DNAArtificial
sequenceDD43 qPCR amplicon 305aaagaagagg cagactccaa ttcctctttt
ctagaatacc ctccgtacgt acaagtacaa 60gggacttgtg agttgtaagg ctgtatttac
aatagtgaaa agagaatcat ctggg 11530620DNAArtificial sequenceprimer,
DD20-CR1 306ggaactgaca cacgacatga 2030720DNAArtificial
sequenceprimer, DD20-CR2 307gacatgatgg aacgtgacta
2030822DNAArtificial sequenceprimer, DD20-F 308attcggaact
gacacacgac at 2230917DNAArtificial sequenceFAM-MGB probe, DD20-T
309atggaacgtg actaagg 1731022DNAArtificial sequenceprimer, DD20-R
310tcgacatgca aagtcaaaaa cc 2231120DNAArtificial sequenceprimer,
DD43CR1 311gtcccttgta cttgtacgta 2031220DNAArtificial
sequenceprimer, DD43CR2 312gtattctaga aaagaggaat
2031326DNAArtificial sequenceprimer, DD43-F 313ttctagaata
ccctccgtac gtacaa 2631426DNAArtificial sequenceprimer, DD43-F2
314aaagaagagg cagactccaa ttcctc 2631519DNAArtificial
sequenceFAM-MGB probe, DD43-T 315caagggactt gtgagttgt
1931626DNAArtificial sequenceprimer, DD43-R 316cccagatgat
tctcttttca ctattg 2631719DNAArtificial sequenceprimer, Cas9-F
317ccttcttcca ccgccttga 1931819DNAArtificial sequenceFAM-MGB probe,
Cas9-T 318aatcattcct ggtggagga 1931921DNAArtificial sequenceprimer,
Cas9-R 319tgggtgtctc tcgtgctttt t 2132022DNAArtificial
sequenceprimer, Sams-76F 320aggcttgttg tgcagttttt ga
2232122DNAArtificial sequenceFAM-MGB probe, FRT1I-63T 321tggactagtg
gaagttccta ta 2232221DNAArtificial sequenceprimer, FRT1I-41F
322gcggtgagtt caggcttttt c 2132331DNAArtificial sequenceprimer,
DD20-LB 323ggttatacct tcttcttagt gtggtctatc c 3132431DNAArtificial
sequenceprimer, Sams-A1 324cccaaaataa ttagtatgat tggtaaggaa g
3132523DNAArtificial sequenceprimer, QC498A-S1 325ggaacttcac
tagagcttgc ggc 2332628DNAArtificial sequenceprimer, DD20-RB
326gccattacat tcttcataag ttcctctc 2832726DNAArtificial
sequenceprimer, DD43-LB 327gtgtagtcca ttgtagccaa gtcacc
2632824DNAArtificial sequenceprimer, DD43-RB 328caaaccggag
agagaggaag aacc 243292105DNAArtificial SequenceDD20 HR1-HR2 PCR
amplicon 329ggttatacct tcttcttagt gtggtctatc ccctagtaat aattacacat
ctaagatatc 60cccttctttt tcaagtaaaa taatatcata tgatctcatt ttagtgaaac
aatactattt 120ccctgataac tctcttcaac attagggact tcatctaatc
atctactttc aaggtataac 180tagacgtatt tgttctttta aaaaaaacac
tagatgtact cgtcaactca aaattcatcg 240ttcatgcatt ttaattaaac
tttaattagc taatgagtag aaaaagatca tacgagtaaa 300atagaagaat
cttcctagat tttggaagaa tggattggag tgtaagtgaa ttgatccatt
360agtggaagat gctctttaca atggccaaac tgttctaatt gttagagcac
atttgagatg 420aaacacttca gtagtggagg taacctacaa tcctaggatc
tgtatcctct atcactaatg 480gagcaatggg tttgagattg acttactcct
ttccttgtct ctcgtagtgc atatgcgcac 540tttcaaaggc tacacaaaag
ccgttaactt tttgtttatt taagttacga aagatagttg 600aattagagta
aatggtgata ttgaattagg attttaaata attttaaaag aattttttta
660ataaaaaaaa tattgtgttg ttggatcaaa atttttaaat aacatgaata
aggaaatgga 720ttgcaatgag gttttaaaca attattttaa catataggat
tttagaaaga cttttataat 780attttgttga agtttagatt ttaatatatt
tatgttttaa aattttaaaa aaaacttcat 840gaatttataa tatttgaaaa
agacacgtga atatttagaa aacatttaaa attacaataa 900taaatcataa
tgagataggg tgtattcatg tgtagacgag acaccaagta tatggttcac
960aagtgaatca tctttttttt ttacagcaca agtagatcac ttgtacttat
caaaattcgg 1020aactgacaca cgacatgatg gaacgtgact aaggtgggtt
tttgactttg catgtcgaag 1080tgagagtgat tttattgaga gaataataga
agacctacaa aacaaatgat cccgacgcta 1140aagtaagtac gagagttaag
agaataaatg ggaaaatatg catacatgat taggtgtgtg 1200ttcgtctcaa
gaaagtacga atgaatatgg tgtgtttgta gtacatgaat gatgtgtttt
1260gagggttcaa gggaaattga tatttataga gtgaaatgga accagaggtc
tttgttgaca 1320agggttgtta tgactcttgc aaataattaa tagcttataa
ataatagcca ataacttatt 1380atagatagag ttagagataa tatatagcta
aatttgaaca aggcatacaa aacaaaaatg 1440ctaaatatga ataagacaat
caaaattgta gtcgatgttc aactctttgt cgttgaagaa 1500cttgtttgca
gtggtatagt aaatgggtgt gagtgcagtg tctcacccat ctcacaccac
1560acaaccaact tcatatctaa agatattgtc gctgaataca aaattgagtt
atggaatata 1620caattcataa tatagatacg aaaaatcatt tcttacaaaa
cattcaatca aaaattattc 1680aaacataatt ctagattaag taatccgaag
tacaagttag tatcctagat ccgttaattt 1740aaaattatgt ttgcataatt
ttggatttgg tgttctataa gggcacaatt ttgttcattc 1800ttacaagttt
gtcaattcta aaatatatgc aaatttgaag aaaaaaaatt tacgaatgtg
1860tctcaaacaa taacttaatg ggaggagaat gagggatgaa gaagctcaaa
attaccaacg 1920ccttctacct caagaagcta cttcacacaa aatatgactg
gcggaaggat aggggacaac 1980cgataacgag aaggagatac ataaggtaat
gtacgttgtt gtgtgaggta cacaattatg 2040gggatgaaga agttcaactt
tagtcgaaaa aatgtttgag aggaacttat gaagaatgta 2100atggc
21053301204DNAArtificial SequenceDD20 HR1-SAMS PCR amplicon
330ggttatacct tcttcttagt gtggtctatc ccctagtaat aattacacat
ctaagatatc 60cccttctttt tcaagtaaaa taatatcata tgatctcatt ttagtgaaac
aatactattt 120ccctgataac tctcttcaac attagggact tcatctaatc
atctactttc aaggtataac 180tagacgtatt tgttctttta aaaaaaacac
tagatgtact cgtcaactca aaattcatcg 240ttcatgcatt ttaattaaac
tttaattagc taatgagtag aaaaagatca tacgagtaaa 300atagaagaat
cttcctagat tttggaagaa tggattggag tgtaagtgaa ttgatccatt
360agtggaagat gctctttaca atggccaaac tgttctaatt gttagagcac
atttgagatg 420aaacacttca gtagtggagg taacctacaa tcctaggatc
tgtatcctct atcactaatg 480gagcaatggg tttgagattg acttactcct
ttccttgtct ctcgtagtgc atatgcgcac 540tttcaaaggc tacacaaaag
ccgttaactt tttgtttatt taagttacga aagatagttg 600aattagagta
aatggtgata ttgaattagg attttaaata attttaaaag aattttttta
660ataaaaaaaa tattgtgttg ttggatcaaa atttttaaat aacatgaata
aggaaatgga 720ttgcaatgag gttttaaaca attattttaa catataggat
tttagaaaga cttttataat 780attttgttga agtttagatt ttaatatatt
tatgttttaa aattttaaaa aaaacttcat 840gaatttataa tatttgaaaa
agacacgtga atatttagaa aacatttaaa attacaataa 900taaatcataa
tgagataggg tgtattcatg tgtagacgag acaccaagta tatggttcac
960aagtgaatca tctttttttt ttacagcaca agtagatcac ttgtacttat
caaaattcgg 1020aactgacaca cactagtggt cacctaagtg actagggtca
cgtgacccta gtcacttatt 1080cccaaacact agtaacggcc gccagtgtgc
tggaattcgc ccttcccaag ctttgctcta 1140gatcaaactc acatccaaac
ataacatgga tatcttcctt accaatcata ctaattattt 1200tggg
12043311459DNAArtificial SequenceDD20 NOS-HR2 PCR amplicon
331ggaacttcac tagagcttgc ggccgcgcat gctgacttaa tcagctaacg
ccactcgacc 60tgcaggcatg cccgcggata tcgatgggcc ccggccgaag cttcaagttt
gtacaaaaaa 120gcaggctggc gccggaacca attcagtcga ctggatccgg
taccgaattc gcggccgcac 180tcgagatatc tagacccagc tttcttgtac
aaagtggccg ttaacggatc ggccagaatc 240cggtaagtga ctagggtcac
gtgaccctag tcacttaaat tcggccagaa tggccatctg 300gattcagcag
gcctagaagg cccggaccga ttaaacttta attcggtccg ggttacctct
360agaaagcttg tcgacctgca gacacgacat gatggaacgt gactaaggtg
ggtttttgac 420tttgcatgtc gaagtgagag tgattttatt gagagaataa
tagaagacct acaaaacaaa 480tgatcccgac gctaaagtaa gtacgagagt
taagagaata aatgggaaaa tatgcataca 540tgattaggtg tgtgttcgtc
tcaagaaagt acgaatgaat atggtgtgtt tgtagtacat 600gaatgatgtg
ttttgagggt tcaagggaaa ttgatattta tagagtgaaa tggaaccaga
660ggtctttgtt gacaagggtt gttatgactc ttgcaaataa ttaatagctt
ataaataata 720gccaataact tattatagat agagttagag ataatatata
gctaaatttg aacaaggcat 780acaaaacaaa aatgctaaat atgaataaga
caatcaaaat tgtagtcgat gttcaactct 840ttgtcgttga agaacttgtt
tgcagtggta tagtaaatgg gtgtgagtgc agtgtctcac 900ccatctcaca
ccacacaacc aacttcatat ctaaagatat tgtcgctgaa tacaaaattg
960agttatggaa tatacaattc ataatataga tacgaaaaat catttcttac
aaaacattca 1020atcaaaaatt attcaaacat aattctagat taagtaatcc
gaagtacaag ttagtatcct 1080agatccgtta atttaaaatt atgtttgcat
aattttggat ttggtgttct ataagggcac 1140aattttgttc attcttacaa
gtttgtcaat tctaaaatat atgcaaattt gaagaaaaaa 1200aatttacgaa
tgtgtctcaa acaataactt aatgggagga gaatgaggga tgaagaagct
1260caaaattacc aacgccttct acctcaagaa gctacttcac acaaaatatg
actggcggaa 1320ggatagggga caaccgataa cgagaaggag atacataagg
taatgtacgt tgttgtgtga 1380ggtacacaat tatggggatg aagaagttca
actttagtcg aaaaaatgtt tgagaggaac 1440ttatgaagaa tgtaatggc
14593322098DNAArtificial SequenceDD43 HR1-HR2 PCR amplicon
332gtgtagtcca ttgtagccaa gtcaccaata tcttgttccc ctccttggtt
tggcataaat 60tgattttcat ggctcttctc ggtcgaaact ggagctaatt cacccttagt
ctctcttaaa 120attctggctg taagaaacac cacagaacac ataaattata
aactaattat aatttgaaga 180gtaaaatatg tttttactct tatgatttaa
ttagtgtagt tttaattttc tccttttttt 240aaaaaatttt ggtattcata
aatttcaatt ttttaaaaat aattgttgtt acccgttaat 300gataacggga
tatgttatgt taccactaaa tcggacaaaa aaaattcaaa acttttataa
360ggattaaaat taacaaaaat attttaaaaa aatctaacct caataaagtt
aaatttataa 420gcacaaaata atacttttaa gcctaatttg gcaagacaca
agcaagctca cctgtagcat 480taatagaaag gaagcaaagc aagagaaaag
caaccagaag gaagcgtttg cttggtgaca 540cagccatctt acttgaattt
atggtattac tgagaaacct tgatcttgct tcaaaatctt 600ctagttaccc
tctttttata ggcagaaaga gaactagcta gttgccaata ggatatgagg
660acatgtggtg caatgcactc actcttcaag gacaagaaaa acaatggcta
caattgtggt 720tcaaatcaat gtctcctgct ctgtcctgcc tgaaaatgac
acccttttgc ttggaaaaga 780ggatcaaagc taagaacagg agtggcttca
ttcccttcat gtaaccaaac actttcgcat 840tctgtcattc gtgaatcagc
aaaatctgca accaaaaata tatggtgcct aaataaaaga 900aataaaataa
tttagagttg cggactaaaa taataaacaa aagaaatata ttataatcta
960gaattaattt aggactaaaa gaagaggcag actccaattc ctcttttcta
gaataccctc 1020cgtacgtaca agtacaaggg acttgtgagt tgtaaggctg
tatttacaat agtgaaaaga 1080gaatcatctg ggtgattggg tttttagtcc
ccagtgacga attaaaggtt tgaattctta 1140gtatgtttgg gaatcaatta
ggaatttcgt tttggacttt ccaaagcaat tattcacttt 1200ttcattcatt
aaatgtgact aaaaaattgt tatttctcca ttggccagga tgcatcgttt
1260atataaacat aaccttagtg aaagcagtgt tttcatgtga cagcggcaga
ctatatctta 1320aacaaaatta cttgtaaaga aagataccgt taggaaaaaa
atgaaaagaa aattgaagct 1380atcacttgtt tactttccta atatctttca
agaatacaat gtggtgaatt tcaattttcc 1440ctacatatgt ataccgtcag
cctgacgcaa cttatgaaac ttctctttct ttcatttgat 1500gtatatataa
agacacatta tatataaaga aactttatat atatctccat catattttag
1560tacttgctac tatgtaaaat tagctgttgg aagtatctca agaaacattt
aatttattga 1620accaagcatt aaccattcat ctacatttga gttctaaaat
aaatcttaaa tgatgtggag 1680gaagggaaat tgttaattat ttccctcttc
tcctacatgg atatacctga aacatgcaat 1740ggatggatta gattttaaca
tttgcagcct gagaagttca ctgactttcc tccagctatt 1800ttatgtgtgc
ccgccaccat ttatagctca tgattgtagc tgaactgcaa aaactgcatc
1860gattgcaaac tgaaattgag aatctctttt caactttata tgctgattga
tgcatgctga 1920gcatgctata ctagtactcg aagttcctat atgtagactt
tgttactgcc taatatactt 1980tgtgtttgtt ctcaagttct tattttattt
catatttttt cctataaaag gttaatggct 2040ctataaaggt tgagtgacat
atatatacta taaaggttct tcctctctct ccggtttg 20983331202DNAArtificial
SequenceDD43 HR1-SAMS PCR PCR amplicon 333gtgtagtcca ttgtagccaa
gtcaccaata tcttgttccc ctccttggtt tggcataaat 60tgattttcat ggctcttctc
ggtcgaaact ggagctaatt cacccttagt ctctcttaaa 120attctggctg
taagaaacac cacagaacac ataaattata aactaattat aatttgaaga
180gtaaaatatg tttttactct tatgatttaa ttagtgtagt tttaattttc
tccttttttt
240aaaaaatttt ggtattcata aatttcaatt ttttaaaaat aattgttgtt
acccgttaat 300gataacggga tatgttatgt taccactaaa tcggacaaaa
aaaattcaaa acttttataa 360ggattaaaat taacaaaaat attttaaaaa
aatctaacct caataaagtt aaatttataa 420gcacaaaata atacttttaa
gcctaatttg gcaagacaca agcaagctca cctgtagcat 480taatagaaag
gaagcaaagc aagagaaaag caaccagaag gaagcgtttg cttggtgaca
540cagccatctt acttgaattt atggtattac tgagaaacct tgatcttgct
tcaaaatctt 600ctagttaccc tctttttata ggcagaaaga gaactagcta
gttgccaata ggatatgagg 660acatgtggtg caatgcactc actcttcaag
gacaagaaaa acaatggcta caattgtggt 720tcaaatcaat gtctcctgct
ctgtcctgcc tgaaaatgac acccttttgc ttggaaaaga 780ggatcaaagc
taagaacagg agtggcttca ttcccttcat gtaaccaaac actttcgcat
840tctgtcattc gtgaatcagc aaaatctgca accaaaaata tatggtgcct
aaataaaaga 900aataaaataa tttagagttg cggactaaaa taataaacaa
aagaaatata ttataatcta 960gaattaattt aggactaaaa gaagaggcag
actccaattc ctcttttcta gaataccctc 1020cgtacgtaca ctagtggtca
cctaagtgac tagggtcacg tgaccctagt cacttattcc 1080caaacactag
taacggccgc cagtgtgctg gaattcgccc ttcccaagct ttgctctaga
1140tcaaactcac atccaaacat aacatggata tcttccttac caatcatact
aattattttg 1200gg 12023341454DNAArtificial SequenceDD43 NOS-HR2 PCR
PCR amplicon 334ggaacttcac tagagcttgc ggccgcgcat gctgacttaa
tcagctaacg ccactcgacc 60tgcaggcatg cccgcggata tcgatgggcc ccggccgaag
cttcaagttt gtacaaaaaa 120gcaggctggc gccggaacca attcagtcga
ctggatccgg taccgaattc gcggccgcac 180tcgagatatc tagacccagc
tttcttgtac aaagtggccg ttaacggatc ggccagaatc 240cggtaagtga
ctagggtcac gtgaccctag tcacttaaat tcggccagaa tggccatctg
300gattcagcag gcctagaagg cccggaccga ttaaacttta attcggtccg
ggttacctct 360agaaagcttg tcgacctgca ggtacaagta caagggactt
gtgagttgta aggctgtatt 420tacaatagtg aaaagagaat catctgggtg
attgggtttt tagtccccag tgacgaatta 480aaggtttgaa ttcttagtat
gtttgggaat caattaggaa tttcgttttg gactttccaa 540agcaattatt
cactttttca ttcattaaat gtgactaaaa aattgttatt tctccattgg
600ccaggatgca tcgtttatat aaacataacc ttagtgaaag cagtgttttc
atgtgacagc 660ggcagactat atcttaaaca aaattacttg taaagaaaga
taccgttagg aaaaaaatga 720aaagaaaatt gaagctatca cttgtttact
ttcctaatat ctttcaagaa tacaatgtgg 780tgaatttcaa ttttccctac
atatgtatac cgtcagcctg acgcaactta tgaaacttct 840ctttctttca
tttgatgtat atataaagac acattatata taaagaaact ttatatatat
900ctccatcata ttttagtact tgctactatg taaaattagc tgttggaagt
atctcaagaa 960acatttaatt tattgaacca agcattaacc attcatctac
atttgagttc taaaataaat 1020cttaaatgat gtggaggaag ggaaattgtt
aattatttcc ctcttctcct acatggatat 1080acctgaaaca tgcaatggat
ggattagatt ttaacatttg cagcctgaga agttcactga 1140ctttcctcca
gctattttat gtgtgcccgc caccatttat agctcatgat tgtagctgaa
1200ctgcaaaaac tgcatcgatt gcaaactgaa attgagaatc tcttttcaac
tttatatgct 1260gattgatgca tgctgagcat gctatactag tactcgaagt
tcctatatgt agactttgtt 1320actgcctaat atactttgtg tttgttctca
agttcttatt ttatttcata ttttttccta 1380taaaaggtta atggctctat
aaaggttgag tgacatatat atactataaa ggttcttcct 1440ctctctccgg tttg
145433560DNAGlycine maxsoybean genomic DD20CR1 target
region(1)..(60) 335acttgtactt atcaaaattc ggaactgaca cacgacatga
tggaacgtga ctaaggtggg 6033659DNAArtificial sequencesequence of
gRNA/Cas9 system mediated NHEJ 336acttgtactt atcaaaattc ggaactgaca
cacgactgat ggaacgtgac taaggtggg 5933759DNAArtificial
sequencesequence of gRNA/Cas9 system mediated NHEJ 337acttgtactt
atcaaaattc ggaactgaca cacgaatgat ggaacgtgac taaggtggg
5933858DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 338acttgtactt atcaaaattc ggaactgaca cacgatgatg gaacgtgact
aaggtggg 5833958DNAArtificial sequencesequence of gRNA/Cas9 system
mediated NHEJ 339acttgtactt atcaaaattc ggaactgaca cacgacgatg
gaacgtgact aaggtggg 5834058DNAArtificial sequencesequence of
gRNA/Cas9 system mediated NHEJ 340acttgtactt atcaaaattc ggaactgaca
cacggtgatg gaacgtgact aaggtggg 5834157DNAArtificial
sequencesequence of gRNA/Cas9 system mediated NHEJ 341acttgtactt
atcaaaattc ggaactgaca cacatgatgg aacgtgacta aggtggg
5734257DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 342acttgtactt atcaaaattc ggaactgaca cacgtgatgg aacgtgacta
aggtggg 5734356DNAArtificial sequencesequence of gRNA/Cas9 system
mediated NHEJ 343acttgtactt atcaaaattc ggaactgaca cactgatgga
acgtgactaa ggtggg 5634456DNAArtificial sequencesequence of
gRNA/Cas9 system mediated NHEJ 344acttgtactt atcaaaattc ggaactgaca
cacggatgga acgtgactaa ggtggg 5634555DNAArtificial sequencesequence
of gRNA/Cas9 system mediated NHEJ 345acttgtactt atcaaaattc
ggaactgaca cacgatggaa cgtgactaag gtggg 5534655DNAArtificial
sequencesequence of gRNA/Cas9 system mediated NHEJ 346acttgtactt
atcaaaattc ggaactgaca catgatggaa cgtgactaag gtggg
5534754DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 347acttgtactt atcaaaattc ggaactgaca cacatggaac gtgactaagg tggg
5434854DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 348acttgtactt atcaaaattc ggaactgaca ctgatggaac gtgactaagg tggg
5434953DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 349acttgtactt atcaaaattc ggaactgaca cgatggaacg tgactaaggt ggg
5335051DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 350acttgtactt atcaaaattc ggaactgatg atggaacgtg actaaggtgg g
5135150DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 351acttgtactt atcaaaattc ggaactgaca tggaacgtga ctaaggtggg
5035250DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 352acttgtactt atcaaaattc ggaactgtga tggaacgtga ctaaggtggg
5035351DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 353acttgtactt atcaaaattc ggaactgaca cacgaacgtg actaaggtgg g
5135450DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 354acttgtactt atcaaaattc ggaactgaca cggaacgtga ctaaggtggg
5035549DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 355acttgtacct atcaaaattc ggaactgaat ggaacgtgac taaggtggg
4935648DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 356acttgtactt atcaaaattc ggaactgatg gaacgtgact aaggtggg
4835746DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 357acttgtactt atcaaaattc ggaactgaga acgtgactaa ggtggg
4635838DNAArtificial sequencesequence of gRNA/Cas9 system mediated
target site modification 358acttgtactt atcaaaattc ggaactgaca
cacgacat 3835938DNAArtificial sequencesequence of gRNA/Cas9 system
mediated NHEJ 359acttgtactt atcaaaattc ggaactgaca aaggtggg
3836039DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 360acttgtactt atcaaaattc ggaacgtgac taaggtggg
3936124DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 361actatggaac gtgactaagg tggg 24362211DNAArtificial
sequencesequence of gRNA/Cas9 system mediated target site
modification 362acttgtactt atcaaaattc ggaactgaca cacggccggt
gatggattgg tggatgagtg 60ttgcgtcgag cacctccttg gtggaggtgt atctcttcct
gtcaatggtg gtgtcgaagt 120acttgaaggc agcaggggct cccaagtttg
tgagggtaaa caggtggata atgttttcag 180cctgctcgcg atggaacgtg
actaaggtgg g 21136390DNAArtificial sequencesequence of gRNA/Cas9
system mediated target site modification 363acttgtactt atcaaaaact
acttgtgctg taaaaaaaaa gaggaacaat cttcactcat 60caataagtga tggaacgcga
ctaaggtggg 9036457DNAGlycine maxsoybean genomic DD20CR2 target
region(1)..(57) 364gacacacgac atgatggaac gtgactaagg tgggtttttg
actttgcatg tcgaagt 5736561DNAartificial sequencesequence of
gRNA/Cas9 system mediated target site modification 365actgacacac
gacatgatgg aacgtgaact aaggtgggtt tttgactttg catgtcgaag 60t
6136659DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 366actgacacac gacatgatgg aacgtactaa ggtgggtttt tgactttgca
tgtcgaagt 5936758DNAArtificial sequencesequence of gRNA/Cas9 system
mediated NHEJ 367actgacacac gacatgatgg aacgtctaag gtgggttttt
gactttgcat gtcgaagt 5836858DNAArtificial sequencesequence of
gRNA/Cas9 system mediated NHEJ 368actgacacac gacatgatgg aacgtgaaag
gtgggttttt gactttgcat gtcgaagt 5836957DNAArtificial
sequencesequence of gRNA/Cas9 system mediated NHEJ 369actgacacac
gacatgatgg aacgctaagg tgggtttttg actttgcatg tcgaagt
5737057DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 370actgacacac gacatgatgg aacgtgaagg tgggtttttg actttgcatg
tcgaagt 5737156DNAArtificial sequencesequence of gRNA/Cas9 system
mediated NHEJ 371actgacacac gacatgatgg aacgtgaggt gggtttttga
ctttgcatgt cgaagt 5637256DNAArtificial sequencesequence of
gRNA/Cas9 system mediated NHEJ 372actgacacac gacatgatgg aacgtaaggt
gggtttttga ctttgcatgt cgaagt 5637356DNAArtificial sequencesequence
of gRNA/Cas9 system mediated NHEJ 373actgacacac gacatgatgg
aacctaaggt gggtttttga ctttgcatgt cgaagt 5637456DNAArtificial
sequencesequence of gRNA/Cas9 system mediated NHEJ 374actgacacac
gacatgatgg aacgtgaggt gggtttttga ctttgcatgt cgaagt
5637555DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 375actgacacac gacatgatgg aactaaggtg ggtttttgac tttgcatgtc
gaagt 5537654DNAArtificial sequencesequence of gRNA/Cas9 system
mediated NHEJ 376actgacacac gacatgatgg aataaggtgg gtttttgact
ttgcatgtcg aagt 5437753DNAArtificial sequencesequence of gRNA/Cas9
system mediated NHEJ 377actgacacac gacatgatgg ctaaggtggg tttttgactt
tgcatgtcga agt 5337853DNAArtificial sequencesequence of gRNA/Cas9
system mediated NHEJ 378actgacacac gacatgatgg ataaggtggg tttttgactt
tgcatgtcga agt 5337951DNAArtificial sequencesequence of gRNA/Cas9
system mediated NHEJ 379actgacacac gacatgatgg aaggtgggtt tttgactttg
catgtcgaag t 5138050DNAArtificial sequencesequence of gRNA/Cas9
system mediated NHEJ 380actgacacac gacatgatgg aggtgggttt ttgactttgc
atgtcgaagt 5038144DNAArtificial sequencesequence of gRNA/Cas9
system mediated NHEJ 381actgacacac gacatgatgg gtttttgact ttgcatgtcg
aagt 4438243DNAArtificial sequencesequence of gRNA/Cas9 system
mediated NHEJ 382actgacacac gacaggtggg tttttgactt tgcatgtcga agt
4338340DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 383actgacacta aggtgggttt ttgactttgc atgtcgaagt
4038425DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 384actgacacac gacatgatgg aacgt 2538520DNAArtificial
sequencesequence of gRNA/Cas9 system mediated NHEJ 385actgacacac
gacatgatgg 2038660DNAGlycine maxsoybean genomic DD43CR1 target
region(1)..(60) 386agccttacaa ctcacaagtc ccttgtactt gtacgtacgg
agggtattct agaaaagagg 6038759DNAArtificial sequencesequence of
gRNA/Cas9 system mediated NHEJ 387agccttacaa ctcacaagtc ccttgtactt
gtactacgga gggtattcta gaaaagagg 5938859DNAArtificial
sequencesequence of gRNA/Cas9 system mediated NHEJ 388agccttacaa
ctcacaagtc ccttgtactt gtagtacgga gggtattcta gaaaagagg
5938958DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 389agccttacaa ctcacaagtc ccttgtactt gtgtacggag ggtattctag
aaaagagg 5839058DNAArtificial sequencesequence of gRNA/Cas9 system
mediated NHEJ 390agccttacaa ctcacaagtc ccttgtactt gcgtacggag
ggtattctag aaaagagg 5839157DNAArtificial sequencesequence of
gRNA/Cas9 system mediated NHEJ 391agccttacaa ctcacaagtc ccttgtactt
ggtacggagg gtattctaga aaagagg 5739257DNAArtificial sequencesequence
of gRNA/Cas9 system mediated NHEJ 392agccttacaa ctcacaagtc
ccttgtactt gttacggagg gtattctaga aaagagg 5739356DNAArtificial
sequencesequence of gRNA/Cas9 system mediated NHEJ 393agccttacaa
ctcacaagtc ccttgtactt gtacggaggg tattctagaa aagagg
5639455DNAArtificial sequencesequence of gRNA/Cas9 system mediated
NHEJ 394agccttacaa ctcacaagtc ccttgtactt tacggagggt attctagaaa
agagg 5539555DNAArtificial sequencesequence of gRNA/Cas9 system
mediated NHEJ 395agccttacaa ctcacaagtc ccttgtactg tacggagggt
attctagaaa agagg 5539654DNAArtificial sequencesequence of gRNA/Cas9
system mediated NHEJ 396agccttacaa ctcacaagcc ccttgtactt acggagggta
ttctagaaaa gagg 5439752DNAArtificial sequencesequence of gRNA/Cas9
system mediated NHEJ 397agccttacaa ctcacaagtc ccttgtatac ggagggtatt
ctagaaaaga gg 5239852DNAArtificial sequencesequence of gRNA/Cas9
system mediated NHEJ 398agccttacaa ctcacaagtc ccttgtgtac ggagggtatt
ctagaaaaga gg 5239950DNAArtificial sequencesequence of gRNA/Cas9
system mediated NHEJ 399agccttacaa ctcacaagtc ccttgtacgg agggtattct
agaaaagagg 5040049DNAArtificial sequencesequence of gRNA/Cas9
system mediated NHEJ 400agccttacaa ctcacaagtc cctttacgga gggtattcta
gaaaagagg 4940148DNAArtificial sequencesequence of gRNA/Cas9 system
mediated NHEJ 401agccttacaa ctcacaagtc ccttacggag ggtattctag
aaaagagg 4840247DNAArtificial sequencesequence of gRNA/Cas9 system
mediated NHEJ 402agccttacaa ctcacaagtc cctacggagg gtattctaga
aaagagg 4740343DNAArtificial sequencesequence of gRNA/Cas9 system
mediated NHEJ 403agccttacaa ctcacaagtc ccttgtactt gtaagaaaag agg
4340449DNAArtificial sequencesequence of gRNA/Cas9 system mediated
target site modification 404agccttacaa ctcacaagtc ctaaattaaa
ggttattcta gaaaagagg 49405227DNAArtificial sequencesequence of
gRNA/Cas9 system mediated target site modification 405agccttacaa
ctcacaagtc ccttgtactt gtagaatcca gttcataaaa caagtgacac 60acaacagata
tgaactggac tacgtcgaac ccacaaatcc cacaaagcgc gtgaaatcaa
120atcgctcaaa ccacaaaaaa gaacaacgcg tttgttacac gctaatacca
aaattatacc 180caaatcttaa gctatttatg cgtacggagg gtattctaga aaagagg
22740697DNAArtificial sequencesequence of gRNA/Cas9 system mediated
target site modification 406agccttacaa ctcacaagtc ccttgtactt
gtaatgctcc cctctaaact cgtatcgctt 60cagagttgag agtacggagg gtattctaga
aaagagg 97407183DNAArtificial sequencesequence of gRNA/Cas9 system
mediated target site modification 407agccttacaa ctcacaagtc
ccttgtatat agatacccac aaaataagta aacccgatcc 60aaaatcttaa atgatgtgga
ggaagggaaa ttgttaatta ttcccctctt ctcctacatg 120gatatacctg
aaacatgcaa tggatggatt agattttgta cggagggtat tctagaaaag 180agg
183408234DNAArtificial sequencesequence of gRNA/Cas9 system
mediated target site modification 408agccttacaa ctcacaagtc
ccttgtactt gtaccagggg atgtttttta tttacattca 60cgtcttttgg aaagagccgc
taaattaagt tctcagttag gcgaaggaag tatgactgct 120ttaccaatag
ttgaaactca atcgggagat gtttcagctt atattcctac taatgtaatt
180tccattacag atggccaaat attcttacgt acggagggta ttctagaaaa gagg
234409280DNAArtificial sequencesequence of gRNA/Cas9 system
mediated target site modification 409agccttacaa ctcacaagtc
ccttgtactt gtaccgaaaa tttcagccat aaaaaaagtt 60ataatagaat ttaaagcaaa
agtttcattt tttaaacata tatactgaca cgctccgata 120aaaatagagg
caagtccgac aacgtcccct ccgaggaggt cgtgaagaag atgaaaaact
180actggagaca gctcttgaac gccaagctca tcacccagcg taagctcgac
aacctgacta 240aggctgagag aggtgtacgg agggtattct agaaaagagg
280410250DNAArtificial sequencesequence of gRNA/Cas9 system
mediated target site modification 410agccttacaa ctcacaagtc
ccttgtactt gtactggatt tggtgaggga tgcttccgtt 60gtcgaaggtt ctctgcttcc
tcaacaggtc ctctctgttc aacttcacca acagctcctc 120ggtaccgtcc
atcttctcaa ggatgaagat cgagtgcttc gactccgtcg agatctctgg
180tgtcgaggac aggttcaacg cctcccttgg gacttgccac gatcgtacgg
agggtattct 240agaaaagagg 250411161DNAArtificial sequencesequence of
gRNA/Cas9 system mediated target site modification 411agccttacaa
ctcacaagtc ccttatgacc tcaaaaaaaa gattcacctc caacacacca 60aataactcga
aaatctcttt cctattctct agaaagtata ggaacttcca ctagtccatg
120aaaaagcctg aactcgtacg gagggtattc tagaaaagag g
161412185DNAArtificial sequencesequence of gRNA/Cas9 system
mediated target site modification 412agccttacaa ctcacaagtc
ccttgtactt gtacacctgg ggcatggaga gcaccttcct 60cacagtagcg aaatccctcc
ctttgtccca cacgatctct ccagtctcac cgttggtctc 120gatcagtggg
cgcttcctga tctcaccgtt ggcgagagtg tacggagggt attctagaaa 180agagg
185413212DNAArtificial sequencesequence of gRNA/Cas9 system
mediated target site modification 413agccttacaa ctcacaagtc
ccttgtactt gtgctaggtt agccgaaaga tggttatcgg 60ttcaaggacg caaggtgccc
ctgctttttc agggtaataa ggggtagaga aaatgcctcg 120agccaaagtt
cgagtaccag gcgctacagc gctgaagtaa tccatgccat actcccagga
180aaagccgtac ggagggtatt ctagaaaaga gg 212414231DNAArtificial
sequencesequence of gRNA/Cas9 system mediated target site
modification 414agccttacaa ctcacaagtc ccttgtactt gtactcaagt
tcttatttta tttcatattt 60tttcctataa aaggttaatg gctctataaa ggttgagtga
cggatccggt cacctaagtg 120actagggtca cgtgacccta gtcacttatt
cccgggcaac tttattatac aaagttgata 180gatctcgaat tcattccgat
taatcgtggc gagggtattc tagaaaagag g 23141598DNAArtificial
sequenceLIGCas-1 mutation 1 415tcctctgtaa cgatttacgc acctgctggg
aattgtaccg tacgtgcccc ggtcggagga 60tatatatacc tcacacgtac gcgtacgcgt
atatatac 9841698DNAArtificial sequenceLIGCas-1 mutation 2
416tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc
ggacggagga 60tatatatacc tcacacgtac gcgtacgcgt atatatac
9841798DNAArtificial
sequenceLIGCas-1 mutation 3 417tcctctgtaa cgatttacgc acctgctggg
aattgtaccg tacgtgcccc gggcggagga 60tatatatacc tcacacgtac gcgtacgcgt
atatatac 9841898DNAArtificial sequenceLIGCas-1 mutation 4
418tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc
ggccggagga 60tatatatacc tcacacgtac gcgtacgcgt atatatac
9841999DNAArtificial sequenceLIGCas-1 mutation 5 419tcctctgtaa
cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggatcggagg 60atatatatac
ctcacacgta cgcgtacgcg tatatatac 9942094DNAArtificial
sequenceLIGCas-1 mutation 6 420tcctctgtaa cgatttacgc acctgctggg
aattgtaccg tacgtgcccc ggaggatata 60tatacctcac acgtacgcgt acgcgtatat
atac 9442181DNAArtificial sequenceLIGCas-1 mutation 7 421tcctctgtaa
cgatttacgc acctgctggg aattgtaccg tacgtgcccc ggttcacacg 60tacgcgtacg
cgtatatata c 8142265DNAArtificial sequenceLIGCas-1 mutation 8
422tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtacgcg
tacgcgtata 60tatac 6542399DNAArtificial sequenceLIGCas-1 mutation 9
423tcctctgtaa cgatttacgc acctgctggg aattgtaccg tacgtgcccc
ggttcggagg 60atatatatac ctcacacgta cgcgtacgcg tatatatac
9942495DNAArtificial sequenceLIGCas-1 mutation 10 424tcctctgtaa
cgatttacgc acctgctggg aattgtaccg tacgtgcccc cggaggatat 60atatacctca
cacgtacgcg tacgcgtata tatac 9542598DNAArtificial sequenceLIGCas-2
mutation 1 425gaagctgtaa cgatttacgc acctgctggg aattgtaccg
tacgtgaccc cggcggagga 60tatatatacc tcacacgtac gcgtacgcgt atatatac
9842698DNAArtificial sequenceLIGCas-2 mutation 2 426gaagctgtaa
cgatttacgc acctgctggg aattgtaccg tacgtgtccc cggcggagga 60tatatatacc
tcacacgtac gcgtacgcgt atatatac 9842796DNAArtificial
sequenceLIGCas-2 mutation 3 427gaagctgtaa cgatttacgc acctgctggg
aattgtaccg tacgtccccg gcggaggata 60tatatacctc acacgtacgc gtacgcgtat
atatac 9642898DNAArtificial sequenceLIGCas-2 mutation 4
428gaagctgtaa cgatttacgc acctgctggg aattgtaccg tacgtggccc
cggcggagga 60tatatatacc tcacacgtac gcgtacgcgt atatatac
9842999DNAArtificial sequenceLIGCas-2 mutation 5 429gaagctgtaa
cgatttacgc acctgctggg aattgtaccg tacgtgcacc ccggcggagg 60atatatatac
ctcacacgta cgcgtacgcg tatatatac 9943087DNAArtificial
sequenceLIGCas-2 mutation 6 430gaagctgtaa cgatttacgc acctgctggg
aattgtaccc ggcggaggat atatatacct 60cacacgtacg cgtacgcgta tatatac
8743192DNAArtificial sequenceLIGCas-2 mutation 7 431gaagctgtaa
cgatttacgc acctgctggg aattgtaccg tccccggcgg aggatatata 60tacctcacac
gtacgcgtac gcgtatatat ac 9243294DNAArtificial sequenceLIGCas-2
mutation 8 432gaagctgtaa cgatttacgc acctgctggg aattgtaccg
tacccccggc ggaggatata 60tatacctcac acgtacgcgt acgcgtatat atac
9443395DNAArtificial sequenceLIGCas-2 mutation 9 433gaagctgtaa
cgatttacgc acctgctggg aattgtaccg tacgccccgg cggaggatat 60atatacctca
cacgtacgcg tacgcgtata tatac 9543488DNAArtificial sequenceLIGCas-2
mutation 10 434gaagctgtaa cgatttacgc acctgctggg aattgtaccc
cggcggagga tatatatacc 60tcacacgtac gcgtacgcgt atatatac
8843598DNAArtificial sequenceLIGCas-3 mutation 1 435aaggcgcaaa
tgagtagcag cgcacgtata tatacgcgta cgcgtacgtt gtgaggtata 60tatatcctcc
gccggggcac gtacggtaca attcccag 9843696DNAArtificial
sequenceLIGCas-3 mutation 2 436aaggcgcaaa tgagtagcag cgcacgtata
tatacgcgta cgcgtacggt gaggtatata 60tatcctccgc cggggcacgt acggtacaat
tcccag 9643795DNAArtificial sequenceLIGCas-3 mutation 3
437aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtacgtg
aggtatatat 60atcctccgcc ggggcacgta cggtacaatt cccag
9543896DNAArtificial sequenceLIGCas-3 mutation 4 438aaggcgcaaa
tgagtagcag cgcacgtata tatacgcgta cgcgtactgt gaggtatata 60tatcctccgc
cggggcacgt acggtacaat tcccag 9643968DNAArtificial sequenceLIGCas-3
mutation 5 439aaggcgcaaa tgagtagcag cgcacgtata tatatcctcc
gccggggcac gtacggtaca 60attcccag 6844093DNAArtificial
sequenceLIGCas-3 mutation 6 440aaggcgcaaa tgagtagcag cgcacgtata
tatacgcgta cgcgtgtgag gtatatatat 60cctccgccgg ggcacgtacg gtacaattcc
cag 9344189DNAArtificial sequenceLIGCas-3 mutation 7 441aaggcgcaaa
tgagtagcag cgcacgtata tatacgcgta cgtgaggtat atatatcctc 60cgccggggca
cgtacggtac aattcccag 8944289DNAArtificial sequenceLIGCas-3 mutation
8 442aaggcgcaaa tgagtagcag cgcacgtata tatacgcgta cgcgtactat
atatatcctc 60cgccggggca cgtacggtac aattcccag 8944394DNAArtificial
sequenceLIGCas-3 mutation 9 443aaggcgcaaa tgagtagcag cgcacgtata
tatacgcgta cgcgtacgga ggtatatata 60tcctccgccg gggcacgtac ggtacaattc
ccag 9444496DNAArtificial sequenceLIGCas-3 mutation 0 444aaggcgcaaa
tgagtagcag cgcacgtata tatacgcgta cgcgtacgat gaggtatata 60tatcctccgc
cggggcacgt acggtacaat tcccag 964451051DNAArtificial
sequenceLIGCas-1_crRNA_Expression_Cassette 445tgagagtaca atgatgaacc
tagattaatc aatgccaaag tctgaaaaat gcaccctcag 60tctatgatcc agaaaatcaa
gattgcttga ggccctgttc ggttgttccg gattagagcc 120ccggattaat
tcctagccgg attacttctc taatttatat agattttgat gagctggaat
180gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt
aatcgctgag 240ctaaattggc atgctgtcag agtgtcagta ttgcagcaag
gtagtgagat aaccggcatc 300atggtgccag tttgatggca ccattagggt
tagagatggt ggccatgggc gcatgtcctg 360gccaactttg tatgatatat
ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg 420gatttcttct
gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca
480aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg
acataatgat 540cccgcttaaa taagcaacct cgcttgtata gttccttgtg
ctctaacaca cgatgatgat 600aagtcgtaaa atagtggtgt ccaaagaatt
tccaggccca gttgtaaaag ctaaaatgct 660attcgaattt ctactagcag
taagtcgtgt ttagaaatta tttttttata tacctttttt 720ccttctatgt
acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa
780agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga
gagggccata 840agaaacatgg cccacggccc aatacgaagc accgcgacga
agcccaaaca gcagtccgta 900ggtggagcaa agcgctgggt aatacgcaaa
cgttttgtcc caccttgact aatcacaaga 960gtggagcgta ccttataaac
cgagccgcaa gcaccgaatt gtaccgtacg tgccccggcg 1020ggttttagag
ctatgctgtt ttgttttttt t 10514461051DNAArtificial
sequenceLIGCas-2_crRNA_Expression_Cassette 446tgagagtaca atgatgaacc
tagattaatc aatgccaaag tctgaaaaat gcaccctcag 60tctatgatcc agaaaatcaa
gattgcttga ggccctgttc ggttgttccg gattagagcc 120ccggattaat
tcctagccgg attacttctc taatttatat agattttgat gagctggaat
180gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt
aatcgctgag 240ctaaattggc atgctgtcag agtgtcagta ttgcagcaag
gtagtgagat aaccggcatc 300atggtgccag tttgatggca ccattagggt
tagagatggt ggccatgggc gcatgtcctg 360gccaactttg tatgatatat
ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg 420gatttcttct
gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca
480aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg
acataatgat 540cccgcttaaa taagcaacct cgcttgtata gttccttgtg
ctctaacaca cgatgatgat 600aagtcgtaaa atagtggtgt ccaaagaatt
tccaggccca gttgtaaaag ctaaaatgct 660attcgaattt ctactagcag
taagtcgtgt ttagaaatta tttttttata tacctttttt 720ccttctatgt
acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa
780agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga
gagggccata 840agaaacatgg cccacggccc aatacgaagc accgcgacga
agcccaaaca gcagtccgta 900ggtggagcaa agcgctgggt aatacgcaaa
cgttttgtcc caccttgact aatcacaaga 960gtggagcgta ccttataaac
cgagccgcaa gcaccgaatt ggaattgtac cgtacgtgcc 1020cgttttagag
ctatgctgtt ttgttttttt t 10514471047DNAArtificial
sequenceLIGCas-3_crRNA_Expression_Cassette 447tgagagtaca atgatgaacc
tagattaatc aatgccaaag tctgaaaaat gcaccctcag 60tctatgatcc agaaaatcaa
gattgcttga ggccctgttc ggttgttccg gattagagcc 120ccggattaat
tcctagccgg attacttctc taatttatat agattttgat gagctggaat
180gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt
aatcgctgag 240ctaaattggc atgctgtcag agtgtcagta ttgcagcaag
gtagtgagat aaccggcatc 300atggtgccag tttgatggca ccattagggt
tagagatggt ggccatgggc gcatgtcctg 360gccaactttg tatgatatat
ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg 420gatttcttct
gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca
480aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg
acataatgat 540cccgcttaaa taagcaacct cgcttgtata gttccttgtg
ctctaacaca cgatgatgat 600aagtcgtaaa atagtggtgt ccaaagaatt
tccaggccca gttgtaaaag ctaaaatgct 660attcgaattt ctactagcag
taagtcgtgt ttagaaatta tttttttata tacctttttt 720ccttctatgt
acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa
780agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga
gagggccata 840agaaacatgg cccacggccc aatacgaagc accgcgacga
agcccaaaca gcagtccgta 900ggtggagcaa agcgctgggt aatacgcaaa
cgttttgtcc caccttgact aatcacaaga 960gtggagcgta ccttataaac
cgagccgcaa gcaccgaatt gcgtacgcgt acgtgtggtt 1020ttagagctat
gctgttttgt ttttttt 10474481087DNAArtificial
sequencetracrRNA_Expression_Cassette 448tgagagtaca atgatgaacc
tagattaatc aatgccaaag tctgaaaaat gcaccctcag 60tctatgatcc agaaaatcaa
gattgcttga ggccctgttc ggttgttccg gattagagcc 120ccggattaat
tcctagccgg attacttctc taatttatat agattttgat gagctggaat
180gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt
aatcgctgag 240ctaaattggc atgctgtcag agtgtcagta ttgcagcaag
gtagtgagat aaccggcatc 300atggtgccag tttgatggca ccattagggt
tagagatggt ggccatgggc gcatgtcctg 360gccaactttg tatgatatat
ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg 420gatttcttct
gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca
480aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg
acataatgat 540cccgcttaaa taagcaacct cgcttgtata gttccttgtg
ctctaacaca cgatgatgat 600aagtcgtaaa atagtggtgt ccaaagaatt
tccaggccca gttgtaaaag ctaaaatgct 660attcgaattt ctactagcag
taagtcgtgt ttagaaatta tttttttata tacctttttt 720ccttctatgt
acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa
780agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga
gagggccata 840agaaacatgg cccacggccc aatacgaagc accgcgacga
agcccaaaca gcagtccgta 900ggtggagcaa agcgctgggt aatacgcaaa
cgttttgtcc caccttgact aatcacaaga 960gtggagcgta ccttataaac
cgagccgcaa gcaccgaatt ggaaccattc aaaacagcat 1020agcaagttaa
aataaggcta gtccgttatc aacttgaaaa agtggcaccg agtcggtgct 1080ttttttt
108744963DNAArtificial SequenceLIGCas-2 forward primer for primary
449ctacactctt tccctacacg acgctcttcc gatctgaagc tgtaacgatt
tacgcacctg 60ctg 6345060DNAArtificial SequenceLIGCas-3 forward
primer for primary PCR 450ctacactctt tccctacacg acgctcttcc
gatctttccc gcaaatgagt agcagcgcac 6045119DNAArtificial
sequenceZm-ARGOS8-CTS1, Cas9 target sequence 1 451gcgtgcatcg
atccatcgc 1945221DNAArtificial sequencem-ARGOS8-CTS2, Cas9 target
sequence 2 452ggctacggat agatatgatg c 2145320DNAArtificial
sequenceZm-ARGOS8-CTS3, Cas9 target sequence 3 453gttacttctc
taagcacggc 2045421DNAArtificial sequenceP1, Forward_primer
454gcgccattcc ctaaaggtaa c 2145523DNAArtificial sequenceP2,
Reverse_primer 455gctaatcgta agtgacgctt gga 2345631DNAArtificial
sequenceP3, Forward_primer 456gctcgtgtcc aagcgtcact tacgattagc t
3145720DNAArtificial sequenceP4, Reverse_primer 457ctgcgaactg
cttgattccg 2045824DNAArtificial sequenceP5, Forward_primer
458accgtcctta tctctgcatc atct 2445931DNAArtificial sequencePBS,
Primer Binding Site 459gctcgtgtcc aagcgtcact tacgattagc t
314601823DNAZea maysmisc_feature(1)..(1823)Zm-GOS2 PRO-GOS2 INTRON,
maize GOS2 promoter and GOS2 intron1 including the promoter,
5'-UTR1, INTRON1 and 5'-UTR2 sequence 460taattattgg ctgtaggatt
ctaaacagag cctaaatagc tggaatagct ctagccctca 60atccaaacta atgatatcta
tacttatgca actctaaatt tttattctaa aagtaatatt 120tcatttttgt
caacgagatt ctctactcta ttccacaatc ttttgaagct atatttacct
180taaatctgta ctctatacca ataatcatat attctattat ttatttttat
ctctctccta 240aggagcatcc ctctatgtct gcatggcccc cgcctcgggt
cccaatctct tgctctgcta 300gtagcacaga agaaaacact agaaatgact
tgcttgactt agagtatcag ataaacatca 360tgtttactta actttaattt
gtatcggttt ctactatttt tataatattt ttgtctctat 420agatactacg
tgcaacagta taatcaacct agtttaatcc agagcgaagg attttttact
480aagtacgtga ctccatatgc acagcgttcc ttttatggtt cctcactggg
cacagcataa 540acgaaccctg tccaatgttt tcagcgcgaa caaacagaaa
ttccatcagc gaacaaacaa 600catacatgcg agatgaaaat aaataataaa
aaaagctccg tctcgatagg ccggcacgaa 660tcgagagcct ccatagccag
ttttttccat cggaacggcg gttcgcgcac ctaattatat 720gcaccacacg
cctataaagc caaccaaccc gtcggagggg cgcaagccag acagaagaca
780gcccgtcagc ccctctcgtt tttcatccgc cttcgcctcc aaccgcgtgc
gctccacgcc 840tcctccagga aagcgagagg tgagcgcagt cccctttccc
ctccttccaa ttcaattcgt 900cttctcgttc gcagccctag gatttggggg
tctggagggg tttgatcgtt tctcgccgtg 960aatctgcttt ggtgtaaacc
aacggatctc ggatcgtagt cttcagaaga tcccggattt 1020tgcggtttgg
cccctcctgg attcaattcg tcgtatcgtt cgcagcccta ggatttgggg
1080atctggaggg gtttgatcgt ttctcgccgc gaatctgctc tggtgtaaac
caacggatct 1140cgggtcgtag tcttcagaag gtcccggatt ttgcggtttg
gcccctcctg gattcaattc 1200gtcgtatcgt tcgcagccct aggatttggg
gatctggagg ggtttgatcc tttctcgccg 1260cgaatctgct ctggtataac
caacggatct cgggtcgtag tcttcagaag gtcccggatt 1320ttgcggtttg
gtggttcttg ctctatgaat cagagggatg gttcttcccg gatttatgcc
1380ttgcggccac tctgtcgaat catggggttt cgacccgatt cgtaggcgtg
ctccctgttt 1440tggatgggaa gtaggcgtgt ttgtagtatt cgtgcttcga
ttcgtcaacg gagattagaa 1500gacctgggat gggatttgag gaaatctagg
tatctgtcta gcacgtttct agatctattc 1560ttcagctgtt atatgagagt
aattttggaa ccctggtggg gtatgtttga ccgagtattc 1620tgtagattat
tgtccgtgac ttgctggctg ttaccgtcct tatctctgca tcatctatct
1680gtgctagttt ctgcgtgctt ctcaaatatt tccggcctgt gtagcatgtg
actgataata 1740tgattttggc agcttctgca taagaacaac aaatcaaaag
cttgatcagc tcggtgccta 1800caaaacctca acaaccaagt ttc
1823461556DNAZea maysmisc_feature(1)..(556)Zm-ARGOS8 promoter
461gttacttctc taagcacggc tggatttcag gcctctagtc ctctactagt
actagctaca 60cgacgtgcac gcatgcatca cagcatcaac aactagacac gcacacgctg
cacgcggccg 120gggaacccac tgattccccc cttccccgcg cgcggtttga
tttcctttcc tggtacggat 180ccatatctga gggcttgttc ggttattccc
aacacacatg tattggatgg gattgaaaaa 240aaaatgagaa gaagtttgac
ttgtttggga ttcaaaccca tccaatccca ctcaatccac 300atggattgag
agctaaccga acaagccctc atagtacata cctggtacgg atccatatca
360tagtacatag atccagtaga atagaaggtg atccgaccgc cggcgcttgc
gttgttttcc 420ccggtccatt gaacctgcca accctcctaa ccacaggcac
gccaaaccgc gggctccggc 480caccaccgcc accgccacct gccctgccgc
acctctccaa ccccaaatcc aggggggggg 540gggggcacca tgcgtg
556462155DNAZea maysmisc_feature(1)..(155)Zm-ARGOS8 5'-UTR
462catcgatcca tcgctggcgc gcgggtccgg cggggcggtc tgtgagggca
aatttatata 60ggtctagtgg gtacccggct acggatagat atgatgctgc actgcacatt
ggctatatct 120gaggctcctg cgcgcgcctt ggccaggtgt ctgtc
155463285DNAZea mays 463atgcgggcga tgccgcagga agaggaagcc gcggtggcga
cgacgaccat ggccgggggc 60aaggtggcgg cgctgctggc cacggcggcc gcgctgctgc
tgctgctccc gctggcgctg 120ccgccgctgc cgccgccgcc cacgcagctg
ttgttcgtcc ccgtggtctt gctgctcctc 180gtggcgtccc tcgcgttctg
ccccgccgcg accccctcgc cgtcgccgat gcatgccgcc 240gaccacgggt
cgttcgggac cactggatca ccgcacctat gttga 2854642843DNAZea
maysmisc_feature(1)..(2843)Zm-GOS2 gene, including promoter,
5'-UTR, CDS, 3'-UTR and introns sequence 464taattattgg ctgtaggatt
ctaaacagag cctaaatagc tggaatagct ctagccctca 60atccaaacta atgatatcta
tacttatgca actctaaatt tttattctaa aagtaatatt 120tcatttttgt
caacgagatt ctctactcta ttccacaatc ttttgaagct atatttacct
180taaatctgta ctctatacca ataatcatat attctattat ttatttttat
ctctctccta 240aggagcatcc ctctatgtct gcatggcccc cgcctcgggt
cccaatctct tgctctgcta 300gtagcacaga agaaaacact agaaatgact
tgcttgactt agagtatcag ataaacatca 360tgtttactta actttaattt
gtatcggttt ctactatttt tataatattt ttgtctctat 420agatactacg
tgcaacagta taatcaacct agtttaatcc agagcgaagg attttttact
480aagtacgtga ctccatatgc acagcgttcc ttttatggtt cctcactggg
cacagcataa 540acgaaccctg tccaatgttt tcagcgcgaa caaacagaaa
ttccatcagc gaacaaacaa 600catacatgcg agatgaaaat aaataataaa
aaaagctccg tctcgatagg ccggcacgaa 660tcgagagcct ccatagccag
ttttttccat cggaacggcg gttcgcgcac ctaattatat 720gcaccacacg
cctataaagc caaccaaccc gtcggagggg cgcaagccag acagaagaca
780gcccgtcagc ccctctcgtt tttcatccgc cttcgcctcc aaccgcgtgc
gctccacgcc 840tcctccagga aagcgagagg tgagcgcagt cccctttccc
ctccttccaa ttcaattcgt 900cttctcgttc gcagccctag gatttggggg
tctggagggg tttgatcgtt tctcgccgtg 960aatctgcttt ggtgtaaacc
aacggatctc ggatcgtagt cttcagaaga tcccggattt 1020tgcggtttgg
cccctcctgg attcaattcg tcgtatcgtt cgcagcccta ggatttgggg
1080atctggaggg gtttgatcgt ttctcgccgc gaatctgctc tggtgtaaac
caacggatct 1140cgggtcgtag tcttcagaag gtcccggatt ttgcggtttg
gcccctcctg gattcaattc 1200gtcgtatcgt tcgcagccct aggatttggg
gatctggagg ggtttgatcc tttctcgccg 1260cgaatctgct ctggtataac
caacggatct cgggtcgtag tcttcagaag gtcccggatt 1320ttgcggtttg
gtggttcttg ctctatgaat cagagggatg gttcttcccg gatttatgcc
1380ttgcggccac tctgtcgaat catggggttt cgacccgatt cgtaggcgtg
ctccctgttt 1440tggatgggaa gtaggcgtgt ttgtagtatt cgtgcttcga
ttcgtcaacg gagattagaa 1500gacctgggat gggatttgag gaaatctagg
tatctgtcta gcacgtttct agatctattc 1560ttcagctgtt atatgagagt
aattttggaa ccctggtggg gtatgtttga ccgagtattc 1620tgtagattat
tgtccgtgac ttgctggctg ttaccgtcct tatctctgca tcatctatct
1680gtgctagttt ctgcgtgctt ctcaaatatt tccggcctgt gtagcatgtg
actgataata 1740tgattttggc agcttctgca taagaacaac aaatcaaaag
cttgatcagc tcggtgccta 1800caaaacctca acaaccaagt ttcatgtctg
atctcgacgt ccagcttcca tctgcctttg 1860gtatggctac ttctcaattc
atgatgccat gttttttttt atattgtggt tttacataat 1920acatagcatc
ttccagcttc ctgaagagta ttactgaata gattgataac atcatacaca
1980cgaagttcat cttgaacatg cttattagtg ttctgtttgc atctgatggt
atggcatcat 2040ctttgataga tccgtttgct gaggcaaatg ctgaggactc
tggtgctggt cctggaacga 2100aggattatgt gcatgtgcgc atccagcagc
gcaacggcag aaagagtctg actacagtcc 2160agggtctgaa gaaagagttc
agctataaca agatcctcaa ggatctgaag aaggaattct 2220gctgcaatgg
tactgtagtt caggacccag agctaggcca ggtaagatac gagaacaatg
2280catttcaagc ttgtaaaaat ggtatctgcc ggttggtgga tatactgatc
tgtttgtccg 2340ctgcaggtca ttcagctcca aggtgaccag cgcaagaatg
ttgctacttt cctagttcag 2400gtattcagaa tcttcagacc tggccagctg
aatactgttt taccataccg atagatgttc 2460aatctgttaa tactgatcgt
gcaattatta cttgtcttgg taggctggga ttgcgaagaa 2520agagaacatc
aagattcacg ggttctaagg gacctgtaaa tgcttgtgcc ctatattgtg
2580tgcctccaca tattggggag cttgaagcat cgacagttac tagtcattgc
ttacttatat 2640aagaacataa gtagtatttg ctattgtcaa gtgtgccttg
cttgatgcaa gttgtgtttt 2700cgtatcatta ttattatgca cggccatcgt
acgtgtatgg cttgtatggg ttattgccaa 2760cttaataaaa gcacactctg
tttgcctata agcactgatg tttgcctcgt catgcacatg 2820ttgagtcggg
ttttatttgt att 2843465800DNAZea maysmisc_feature(1)..(800)Zm-GOS2
PRO, maize GOS2 promoter 465taattattgg ctgtaggatt ctaaacagag
cctaaatagc tggaatagct ctagccctca 60atccaaacta atgatatcta tacttatgca
actctaaatt tttattctaa aagtaatatt 120tcatttttgt caacgagatt
ctctactcta ttccacaatc ttttgaagct atatttacct 180taaatctgta
ctctatacca ataatcatat attctattat ttatttttat ctctctccta
240aggagcatcc ctctatgtct gcatggcccc cgcctcgggt cccaatctct
tgctctgcta 300gtagcacaga agaaaacact agaaatgact tgcttgactt
agagtatcag ataaacatca 360tgtttactta actttaattt gtatcggttt
ctactatttt tataatattt ttgtctctat 420agatactacg tgcaacagta
taatcaacct agtttaatcc agagcgaagg attttttact 480aagtacgtga
ctccatatgc acagcgttcc ttttatggtt cctcactggg cacagcataa
540acgaaccctg tccaatgttt tcagcgcgaa caaacagaaa ttccatcagc
gaacaaacaa 600catacatgcg agatgaaaat aaataataaa aaaagctccg
tctcgatagg ccggcacgaa 660tcgagagcct ccatagccag ttttttccat
cggaacggcg gttcgcgcac ctaattatat 720gcaccacacg cctataaagc
caaccaaccc gtcggagggg cgcaagccag acagaagaca 780gcccgtcagc
ccctctcgtt 8004661023DNAZea maysmisc_feature(1)..(1023)GOS2 INTRON,
maize GOS2 5'-UTR1 and intron1 and 5'-UTR2 sequence 466tttcatccgc
cttcgcctcc aaccgcgtgc gctccacgcc tcctccagga aagcgagagg 60tgagcgcagt
cccctttccc ctccttccaa ttcaattcgt cttctcgttc gcagccctag
120gatttggggg tctggagggg tttgatcgtt tctcgccgtg aatctgcttt
ggtgtaaacc 180aacggatctc ggatcgtagt cttcagaaga tcccggattt
tgcggtttgg cccctcctgg 240attcaattcg tcgtatcgtt cgcagcccta
ggatttgggg atctggaggg gtttgatcgt 300ttctcgccgc gaatctgctc
tggtgtaaac caacggatct cgggtcgtag tcttcagaag 360gtcccggatt
ttgcggtttg gcccctcctg gattcaattc gtcgtatcgt tcgcagccct
420aggatttggg gatctggagg ggtttgatcc tttctcgccg cgaatctgct
ctggtataac 480caacggatct cgggtcgtag tcttcagaag gtcccggatt
ttgcggtttg gtggttcttg 540ctctatgaat cagagggatg gttcttcccg
gatttatgcc ttgcggccac tctgtcgaat 600catggggttt cgacccgatt
cgtaggcgtg ctccctgttt tggatgggaa gtaggcgtgt 660ttgtagtatt
cgtgcttcga ttcgtcaacg gagattagaa gacctgggat gggatttgag
720gaaatctagg tatctgtcta gcacgtttct agatctattc ttcagctgtt
atatgagagt 780aattttggaa ccctggtggg gtatgtttga ccgagtattc
tgtagattat tgtccgtgac 840ttgctggctg ttaccgtcct tatctctgca
tcatctatct gtgctagttt ctgcgtgctt 900ctcaaatatt tccggcctgt
gtagcatgtg actgataata tgattttggc agcttctgca 960taagaacaac
aaatcaaaag cttgatcagc tcggtgccta caaaacctca acaaccaagt 1020ttc
102346723DNAGlycine max 467gcgtcctttg acagcagctg tgg
2346823DNAGlycine max 468gcaaccacag ctgctgtcaa agg
23469434DNAGlycine max 469ccgggtgtga tttagtataa agtgaagtaa
tggtcaaaag aaaaagtgta aaacgaagta 60cctagtaata agtaatattg aacaaaataa
atggtaaagt gtcagatata taaaataggc 120tttaataaaa ggaagaaaaa
aaacaaacaa aaaataggtt gcaatggggc agagcagagt 180catcatgaag
ctagaaaggc taccgataga taaactatag ttaattaaat acattaaaaa
240atacttggat ctttctctta ccctgtttat attgagacct gaaacttgag
agagatacac 300taatcttgcc ttgttgtttc attccctaac ttacaggact
cagcgcatgt catgtggtct 360cgttccccat ttaagtccca caccgtctaa
acttattaaa ttattaatgt ttataactag 420atgcacaaca acaa
4344709093DNAArtificial sequenceQC878 470ccgggtgtga tttagtataa
agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta 60cctagtaata agtaatattg
aacaaaataa atggtaaagt gtcagatata taaaataggc 120tttaataaaa
ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt
180catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat
acattaaaaa 240atacttggat ctttctctta ccctgtttat attgagacct
gaaacttgag agagatacac 300taatcttgcc ttgttgtttc attccctaac
ttacaggact cagcgcatgt catgtggtct 360cgttccccat ttaagtccca
caccgtctaa acttattaaa ttattaatgt ttataactag 420atgcacaaca
acaaagcttg cgtcctttga cagcagctgg ttttagagct agaaatagca
480agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc
ggtgcttttt 540tttgcggccg caattggatc gggtttactt attttgtggg
tatctatact tttattagat 600ttttaatcag gctcctgatt tctttttatt
tcgattgaat tcctgaactt gtattattca 660gtagatcgaa taaattataa
aaagataaaa tcataaaata atattttatc ctatcaatca 720tattaaagca
atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt
780tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt
attactttta 840aaaaaatcat aaaggtttag tattttttta aaataaatat
aggaatagtt ttactattca 900ctgctttaat agaaaaatag tttaaaattt
aagatagttt taatcccagc atttgccacg 960tttgaacgtg agccgaaacg
atgtcgttac attatcttaa cctagctgaa acgatgtcgt 1020cataatatcg
ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg
1080aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct
caatcccacg 1140cgagtagagc acagtaacct tcaaataagc gaatggggca
taatcagaaa tccgaaataa 1200acctaggggc attatcggaa atgaaaagta
gctcactcaa tataaaaatc taggaaccct 1260agttttcgtt atcactctgt
gctccctcgc tctatttctc agtctctgtg tttgcggctg 1320aggattccga
acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc
1380tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg
ttatgttttt 1440ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt
cgctttgttt ttgtggttca 1500gttttttagg attcttttgg tttttgaatc
gattaatcgg aagagatttt cgagttattt 1560ggtgtgttgg aggtgaatct
tttttttgag gtcatagatc tgttgtattt gtgttataaa 1620catgcgactt
tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc
1680tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag
gtttgtttta 1740acaggattaa aagtttttta agcatgttga aggagtcttg
tagatatgta accgtcgata 1800gtttttttgt gggtttgttc acatgttatc
aagcttaatc ttttactatg tatgcgacca 1860tatctggatc cagcaaaggc
gattttttaa ttccttgtga aacttttgta atatgaagtt 1920gaaattttgt
tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta
1980tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta
tttctttgaa 2040ttgattctag tttaagtaat ccatggacaa aaagtactca
atagggctcg acatagggac 2100taactccgtt ggatgggccg tcatcaccga
cgagtacaag gtgccctcca agaagttcaa 2160ggtgttggga aacaccgaca
ggcacagcat aaagaagaat ttgatcggtg ccctcctctt 2220cgactccgga
gagaccgctg aggctaccag gctcaagagg accgctagaa ggcgctacac
2280cagaaggaag aacagaatct gctacctgca ggagatcttc tccaacgaga
tggccaaggt 2340ggacgactcc ttcttccacc gccttgagga atcattcctg
gtggaggagg ataaaaagca 2400cgagagacac ccaatcttcg ggaacatcgt
cgacgaggtg gcctaccatg aaaagtaccc 2460taccatctac cacctgagga
agaagctggt cgactctacc gacaaggctg acttgcgctt 2520gatttacctg
gctctcgctc acatgataaa gttccgcgga cacttcctca ttgagggaga
2580cctgaaccca gacaactccg acgtggacaa gctcttcatc cagctcgttc
agacctacaa 2640ccagcttttc gaggagaacc caatcaacgc cagtggagtt
gacgccaagg ctatcctctc 2700tgctcgtctg tcaaagtcca ggaggcttga
gaacttgatt gcccagctgc ctggcgaaaa 2760gaagaacgga ctgttcggaa
acttgatcgc tctctccctg ggattgactc ccaacttcaa 2820gtccaacttc
gacctcgccg aggacgctaa gttgcagttg tctaaagaca cctacgacga
2880tgacctcgac aacttgctgg cccagatagg cgaccaatac gccgatctct
tcctcgccgc 2940taagaacttg tccgacgcaa tcctgctgtc cgacatcctg
agagtcaaca ctgagattac 3000caaagctcct ctgtctgctt ccatgattaa
gcgctacgac gagcaccacc aagatctgac 3060cctgctcaag gccctggtga
gacagcagct gcccgagaag tacaaggaga tctttttcga 3120ccagtccaag
aacggctacg ccggatacat tgacggaggc gcctcccagg aagagttcta
3180caagttcatc aagcccatcc ttgagaagat ggacggtacc gaggagctgt
tggtgaagtt 3240gaacagagag gacctgttga ggaagcagag aaccttcgac
aacggaagca tccctcacca 3300aatccacctg ggagagctcc acgccatctt
gaggaggcag gaggatttct atcccttcct 3360gaaggacaac cgcgagaaga
ttgagaagat cttgaccttc agaattcctt actacgtcgg 3420gccactcgcc
agaggaaact ctaggttcgc ctggatgacc cgcaaatctg aagagaccat
3480tactccctgg aacttcgagg aagtcgtgga caagggcgct tccgctcagt
ctttcatcga 3540gaggatgacc aacttcgata aaaatctgcc caacgagaag
gtgctgccca agcactccct 3600gttgtacgag tatttcacag tgtacaacga
gctcaccaag gtgaagtacg tcacagaggg 3660aatgaggaag cctgccttct
tgtccggaga gcagaagaag gccatcgtcg acctgctctt 3720caagaccaac
aggaaggtga ctgtcaagca gctgaaggag gactacttca agaagatcga
3780gtgcttcgac tccgtcgaga tctctggtgt cgaggacagg ttcaacgcct
cccttgggac 3840ttaccacgat ctgctcaaga ttattaaaga caaggacttc
ctggacaacg aggagaacga 3900ggacatcctt gaggacatcg tgctcaccct
gaccttgttc gaagacaggg aaatgatcga 3960agagaggctc aagacctacg
cccacctctt cgacgacaag gtgatgaaac agctgaagag 4020acgcagatat
accggctggg gaaggctctc ccgcaaattg atcaacggga tcagggacaa
4080gcagtcaggg aagactatac tcgacttcct gaagtccgac ggattcgcca
acaggaactt 4140catgcagctc attcacgacg actccttgac cttcaaggag
gacatccaga aggctcaggt 4200gtctggacag ggtgactcct tgcatgagca
cattgctaac ttggccggct ctcccgctat 4260taagaagggc attttgcaga
ccgtgaaggt cgttgacgag ctcgtgaagg tgatgggacg 4320ccacaagcca
gagaacatcg ttattgagat ggctcgcgag aaccaaacta cccagaaagg
4380gcagaagaat tcccgcgaga ggatgaagcg cattgaggag ggcataaaag
agcttggctc 4440tcagatcctc aaggagcacc ccgtcgagaa cactcagctg
cagaacgaga agctgtacct 4500gtactacctc caaaacggaa gggacatgta
cgtggaccag gagctggaca tcaacaggtt 4560gtccgactac gacgtcgacc
acatcgtgcc tcagtccttc ctgaaggatg actccatcga 4620caataaagtg
ctgacacgct ccgataaaaa tagaggcaag tccgacaacg tcccctccga
4680ggaggtcgtg aagaagatga aaaactactg gagacagctc ttgaacgcca
agctcatcac 4740ccagcgtaag ttcgacaacc tgactaaggc tgagagagga
ggattgtccg agctcgataa 4800ggccggattc atcaagagac agctcgtcga
aacccgccaa attaccaagc acgtggccca 4860aattctggat tcccgcatga
acaccaagta cgatgaaaat gacaagctga tccgcgaggt 4920caaggtgatc
accttgaagt ccaagctggt ctccgacttc cgcaaggact tccagttcta
4980caaggtgagg gagatcaaca actaccacca cgcacacgac gcctacctca
acgctgtcgt 5040tggaaccgcc ctcatcaaaa aatatcctaa gctggagtct
gagttcgtct acggcgacta 5100caaggtgtac gacgtgagga agatgatcgc
taagtctgag caggagatcg gcaaggccac 5160cgccaagtac ttcttctact
ccaacatcat gaacttcttc aagaccgaga tcactctcgc 5220caacggtgag
atcaggaagc gcccactgat cgagaccaac ggtgagactg gagagatcgt
5280gtgggacaaa gggagggatt tcgctactgt gaggaaggtg ctctccatgc
ctcaggtgaa 5340catcgtcaag aagaccgaag ttcagaccgg aggattctcc
aaggagtcca tcctccccaa 5400gagaaactcc gacaagctga tcgctagaaa
gaaagactgg gaccctaaga agtacggagg 5460cttcgattct cctaccgtgg
cctactctgt gctggtcgtg gccaaggtgg agaagggcaa 5520gtccaagaag
ctgaaatccg tcaaggagct cctcgggatt accatcatgg agaggagttc
5580cttcgagaag aaccctatcg acttcctgga ggccaaggga tataaagagg
tgaagaagga 5640cctcatcatc aagctgccca agtactccct cttcgagttg
gagaacggaa ggaagaggat 5700gctggcttct gccggagagt tgcagaaggg
aaatgagctc gcccttccct ccaagtacgt 5760gaacttcctg tacctcgcct
ctcactatga aaagttgaag ggctctcctg aggacaacga 5820gcagaagcag
ctcttcgtgg agcagcacaa gcactacctg gacgaaatta tcgagcagat
5880ctctgagttc tccaagcgcg tgatattggc cgacgccaac ctcgacaagg
tgctgtccgc 5940ctacaacaag cacagggata agcccattcg cgagcaggct
gaaaacatta tccacctgtt 6000taccctcaca aacttgggag cccctgctgc
cttcaagtac ttcgacacca ccattgacag 6060gaagagatac acctccacca
aggaggtgct cgacgcaaca ctcatccacc aatccatcac 6120cggcctctat
gaaacaagga ttgacttgtc ccagctggga ggcgactcta gagccgatcc
6180caagaagaag agaaaggtgt aggttaacct agacttgtcc atcttctgga
ttggccaact 6240taattaatgt atgaaataaa aggatgcaca catagtgaca
tgctaatcac tataatgtgg 6300gcatcaaagt tgtgtgttat gtgtaattac
tagttatctg aataaaagag aaagagatca 6360tccatatttc ttatcctaaa
tgaatgtcac gtgtctttat aattctttga tgaaccagat 6420gcatttcatt
aaccaaatcc atatacatat aaatattaat catatataat taatatcaat
6480tgggttagca aaacaaatct agtctaggtg tgttttgcga attcgatatc
aagcttatcg 6540ataccgtcga gggggggccc ggtaccggcg cgccgttcta
tagtgtcacc taaatcgtat 6600gtgtatgata cataaggtta tgtattaatt
gtagccgcgt tctaacgaca atatgtccat 6660atggtgcact ctcagtacaa
tctgctctga tgccgcatag ttaagccagc cccgacaccc 6720gccaacaccc
gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca
6780agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat
caccgaaacg 6840cgcgagacga aagggcctcg tgatacgcct atttttatag
gttaatgtca tgaccaaaat 6900cccttaacgt gagttttcgt tccactgagc
gtcagacccc gtagaaaaga tcaaaggatc 6960ttcttgagat cctttttttc
tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct 7020accagcggtg
gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg
7080cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt
taggccacca 7140cttcaagaac tctgtagcac cgcctacata cctcgctctg
ctaatcctgt taccagtggc 7200tgctgccagt ggcgataagt cgtgtcttac
cgggttggac tcaagacgat agttaccgga 7260taaggcgcag cggtcgggct
gaacgggggg ttcgtgcaca cagcccagct tggagcgaac 7320gacctacacc
gaactgagat acctacagcg tgagcattga gaaagcgcca cgcttcccga
7380agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag
agcgcacgag 7440ggagcttcca gggggaaacg cctggtatct ttatagtcct
gtcgggtttc gccacctctg 7500acttgagcgt cgatttttgt gatgctcgtc
aggggggcgg agcctatgga aaaacgccag 7560caacgcggcc tttttacggt
tcctggcctt ttgctggcct tttgctcaca tgttctttcc 7620tgcgttatcc
cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc
7680tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg
aagagcgccc 7740aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat
taatgcaggt tgatcagatc 7800tcgatcccgc gaaattaata cgactcacta
tagggagacc acaacggttt ccctctagaa 7860ataattttgt ttaactttaa
gaaggagata tacccatgga aaagcctgaa ctcaccgcga 7920cgtctgtcga
gaagtttctg atcgaaaagt tcgacagcgt ctccgacctg atgcagctct
7980cggagggcga agaatctcgt gctttcagct tcgatgtagg agggcgtgga
tatgtcctgc 8040gggtaaatag ctgcgccgat ggtttctaca aagatcgtta
tgtttatcgg cactttgcat 8100cggccgcgct cccgattccg gaagtgcttg
acattgggga attcagcgag agcctgacct 8160attgcatctc ccgccgtgca
cagggtgtca cgttgcaaga cctgcctgaa accgaactgc 8220ccgctgttct
gcagccggtc gcggaggcta tggatgcgat cgctgcggcc gatcttagcc
8280agacgagcgg gttcggccca ttcggaccgc aaggaatcgg tcaatacact
acatggcgtg 8340atttcatatg cgcgattgct gatccccatg tgtatcactg
gcaaactgtg atggacgaca 8400ccgtcagtgc gtccgtcgcg caggctctcg
atgagctgat gctttgggcc gaggactgcc 8460ccgaagtccg gcacctcgtg
cacgcggatt tcggctccaa caatgtcctg acggacaatg 8520gccgcataac
agcggtcatt gactggagcg aggcgatgtt cggggattcc caatacgagg
8580tcgccaacat cttcttctgg aggccgtggt tggcttgtat ggagcagcag
acgcgctact 8640tcgagcggag gcatccggag cttgcaggat cgccgcggct
ccgggcgtat atgctccgca 8700ttggtcttga ccaactctat cagagcttgg
ttgacggcaa tttcgatgat gcagcttggg 8760cgcagggtcg atgcgacgca
atcgtccgat ccggagccgg gactgtcggg cgtacacaaa 8820tcgcccgcag
aagcgcggcc gtctggaccg atggctgtgt agaagtactc gccgatagtg
8880gaaaccgacg ccccagcact cgtccgaggg caaaggaata gtgaggtaca
gcttggatcg 8940atccggctgc taacaaagcc cgaaaggaag ctgagttggc
tgctgccacc gctgagcaat 9000aactagcata accccttggg gcctctaaac
gggtcttgag gggttttttg ctgaaaggag 9060gaactatatc cggatgatcg
ggcgcgccgg tac 90934719093DNAArtificial sequenceQC879 471ccgggtgtga
tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta 60cctagtaata
agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc
120tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc
agagcagagt 180catcatgaag ctagaaaggc taccgataga taaactatag
ttaattaaat acattaaaaa 240atacttggat ctttctctta ccctgtttat
attgagacct gaaacttgag agagatacac 300taatcttgcc ttgttgtttc
attccctaac ttacaggact cagcgcatgt catgtggtct 360cgttccccat
ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag
420atgcacaaca acaaagcttg caaccacagc tgctgtcaag ttttagagct
agaaatagca 480agttaaaata aggctagtcc gttatcaact tgaaaaagtg
gcaccgagtc ggtgcttttt 540tttgcggccg caattggatc gggtttactt
attttgtggg tatctatact tttattagat 600ttttaatcag gctcctgatt
tctttttatt tcgattgaat tcctgaactt gtattattca 660gtagatcgaa
taaattataa aaagataaaa tcataaaata atattttatc ctatcaatca
720tattaaagca atgaatatgt aaaattaatc ttatctttat tttaaaaaat
catataggtt 780tagtattttt ttaaaaataa agataggatt agttttacta
ttcactgctt attactttta 840aaaaaatcat aaaggtttag tattttttta
aaataaatat aggaatagtt ttactattca 900ctgctttaat agaaaaatag
tttaaaattt aagatagttt taatcccagc atttgccacg 960tttgaacgtg
agccgaaacg atgtcgttac attatcttaa cctagctgaa acgatgtcgt
1020cataatatcg ccaaatgcca actggactac gtcgaaccca caaatcccac
aaagcgcgtg 1080aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt
gttacacgct caatcccacg 1140cgagtagagc acagtaacct tcaaataagc
gaatggggca taatcagaaa tccgaaataa 1200acctaggggc attatcggaa
atgaaaagta gctcactcaa tataaaaatc taggaaccct 1260agttttcgtt
atcactctgt gctccctcgc tctatttctc agtctctgtg tttgcggctg
1320aggattccga acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc
tgctcttgtc 1380tcttcgattc gatctatgcc tgtctcttat ttacgatgat
gtttcttcgg ttatgttttt 1440ttatttatgc tttatgctgt tgatgttcgg
ttgtttgttt cgctttgttt ttgtggttca 1500gttttttagg attcttttgg
tttttgaatc gattaatcgg aagagatttt cgagttattt 1560ggtgtgttgg
aggtgaatct tttttttgag gtcatagatc tgttgtattt gtgttataaa
1620catgcgactt tgtatgattt tttacgaggt tatgatgttc tggttgtttt
attatgaatc 1680tgttgagaca gaaccatgat ttttgttgat gttcgtttac
actattaaag gtttgtttta 1740acaggattaa aagtttttta agcatgttga
aggagtcttg tagatatgta accgtcgata 1800gtttttttgt gggtttgttc
acatgttatc aagcttaatc ttttactatg tatgcgacca 1860tatctggatc
cagcaaaggc gattttttaa ttccttgtga aacttttgta atatgaagtt
1920gaaattttgt tattggtaaa ctataaatgt gtgaagttgg agtatacctt
taccttctta 1980tttggctttg tgatagttta atttatatgt attttgagtt
ctgacttgta tttctttgaa 2040ttgattctag tttaagtaat ccatggacaa
aaagtactca atagggctcg acatagggac 2100taactccgtt ggatgggccg
tcatcaccga cgagtacaag gtgccctcca agaagttcaa 2160ggtgttggga
aacaccgaca ggcacagcat aaagaagaat ttgatcggtg ccctcctctt
2220cgactccgga gagaccgctg aggctaccag gctcaagagg accgctagaa
ggcgctacac 2280cagaaggaag aacagaatct gctacctgca ggagatcttc
tccaacgaga tggccaaggt 2340ggacgactcc ttcttccacc gccttgagga
atcattcctg gtggaggagg ataaaaagca 2400cgagagacac ccaatcttcg
ggaacatcgt cgacgaggtg gcctaccatg aaaagtaccc 2460taccatctac
cacctgagga agaagctggt cgactctacc gacaaggctg acttgcgctt
2520gatttacctg gctctcgctc acatgataaa gttccgcgga cacttcctca
ttgagggaga 2580cctgaaccca gacaactccg acgtggacaa gctcttcatc
cagctcgttc agacctacaa 2640ccagcttttc gaggagaacc caatcaacgc
cagtggagtt gacgccaagg ctatcctctc 2700tgctcgtctg tcaaagtcca
ggaggcttga gaacttgatt gcccagctgc ctggcgaaaa 2760gaagaacgga
ctgttcggaa acttgatcgc tctctccctg ggattgactc ccaacttcaa
2820gtccaacttc gacctcgccg aggacgctaa gttgcagttg tctaaagaca
cctacgacga 2880tgacctcgac aacttgctgg cccagatagg cgaccaatac
gccgatctct tcctcgccgc 2940taagaacttg tccgacgcaa tcctgctgtc
cgacatcctg agagtcaaca ctgagattac 3000caaagctcct ctgtctgctt
ccatgattaa gcgctacgac gagcaccacc aagatctgac 3060cctgctcaag
gccctggtga gacagcagct gcccgagaag tacaaggaga tctttttcga
3120ccagtccaag aacggctacg ccggatacat tgacggaggc gcctcccagg
aagagttcta 3180caagttcatc aagcccatcc ttgagaagat ggacggtacc
gaggagctgt tggtgaagtt 3240gaacagagag gacctgttga ggaagcagag
aaccttcgac aacggaagca tccctcacca 3300aatccacctg ggagagctcc
acgccatctt gaggaggcag gaggatttct atcccttcct 3360gaaggacaac
cgcgagaaga ttgagaagat cttgaccttc agaattcctt actacgtcgg
3420gccactcgcc agaggaaact ctaggttcgc ctggatgacc cgcaaatctg
aagagaccat 3480tactccctgg aacttcgagg aagtcgtgga caagggcgct
tccgctcagt ctttcatcga 3540gaggatgacc aacttcgata aaaatctgcc
caacgagaag gtgctgccca agcactccct 3600gttgtacgag tatttcacag
tgtacaacga gctcaccaag gtgaagtacg tcacagaggg 3660aatgaggaag
cctgccttct tgtccggaga gcagaagaag gccatcgtcg acctgctctt
3720caagaccaac aggaaggtga ctgtcaagca gctgaaggag gactacttca
agaagatcga 3780gtgcttcgac tccgtcgaga tctctggtgt cgaggacagg
ttcaacgcct cccttgggac 3840ttaccacgat ctgctcaaga ttattaaaga
caaggacttc ctggacaacg aggagaacga 3900ggacatcctt gaggacatcg
tgctcaccct gaccttgttc gaagacaggg aaatgatcga 3960agagaggctc
aagacctacg cccacctctt cgacgacaag gtgatgaaac agctgaagag
4020acgcagatat accggctggg gaaggctctc ccgcaaattg atcaacggga
tcagggacaa 4080gcagtcaggg aagactatac tcgacttcct gaagtccgac
ggattcgcca acaggaactt 4140catgcagctc attcacgacg actccttgac
cttcaaggag gacatccaga aggctcaggt 4200gtctggacag ggtgactcct
tgcatgagca cattgctaac ttggccggct ctcccgctat 4260taagaagggc
attttgcaga ccgtgaaggt cgttgacgag ctcgtgaagg tgatgggacg
4320ccacaagcca gagaacatcg ttattgagat ggctcgcgag aaccaaacta
cccagaaagg 4380gcagaagaat tcccgcgaga ggatgaagcg cattgaggag
ggcataaaag agcttggctc 4440tcagatcctc aaggagcacc ccgtcgagaa
cactcagctg cagaacgaga agctgtacct 4500gtactacctc caaaacggaa
gggacatgta cgtggaccag gagctggaca tcaacaggtt 4560gtccgactac
gacgtcgacc acatcgtgcc tcagtccttc ctgaaggatg actccatcga
4620caataaagtg ctgacacgct ccgataaaaa tagaggcaag tccgacaacg
tcccctccga 4680ggaggtcgtg aagaagatga aaaactactg gagacagctc
ttgaacgcca agctcatcac 4740ccagcgtaag ttcgacaacc tgactaaggc
tgagagagga ggattgtccg agctcgataa 4800ggccggattc atcaagagac
agctcgtcga aacccgccaa attaccaagc acgtggccca 4860aattctggat
tcccgcatga acaccaagta cgatgaaaat gacaagctga tccgcgaggt
4920caaggtgatc accttgaagt ccaagctggt ctccgacttc cgcaaggact
tccagttcta 4980caaggtgagg gagatcaaca actaccacca cgcacacgac
gcctacctca acgctgtcgt 5040tggaaccgcc ctcatcaaaa aatatcctaa
gctggagtct gagttcgtct acggcgacta 5100caaggtgtac gacgtgagga
agatgatcgc taagtctgag caggagatcg gcaaggccac 5160cgccaagtac
ttcttctact ccaacatcat gaacttcttc aagaccgaga tcactctcgc
5220caacggtgag atcaggaagc gcccactgat cgagaccaac ggtgagactg
gagagatcgt 5280gtgggacaaa gggagggatt tcgctactgt gaggaaggtg
ctctccatgc ctcaggtgaa 5340catcgtcaag aagaccgaag ttcagaccgg
aggattctcc aaggagtcca tcctccccaa 5400gagaaactcc gacaagctga
tcgctagaaa gaaagactgg gaccctaaga agtacggagg 5460cttcgattct
cctaccgtgg cctactctgt gctggtcgtg gccaaggtgg agaagggcaa
5520gtccaagaag ctgaaatccg tcaaggagct cctcgggatt accatcatgg
agaggagttc 5580cttcgagaag aaccctatcg acttcctgga ggccaaggga
tataaagagg tgaagaagga 5640cctcatcatc aagctgccca agtactccct
cttcgagttg gagaacggaa ggaagaggat 5700gctggcttct gccggagagt
tgcagaaggg aaatgagctc gcccttccct ccaagtacgt 5760gaacttcctg
tacctcgcct ctcactatga aaagttgaag ggctctcctg aggacaacga
5820gcagaagcag ctcttcgtgg agcagcacaa gcactacctg gacgaaatta
tcgagcagat 5880ctctgagttc tccaagcgcg tgatattggc cgacgccaac
ctcgacaagg tgctgtccgc 5940ctacaacaag cacagggata agcccattcg
cgagcaggct gaaaacatta tccacctgtt 6000taccctcaca aacttgggag
cccctgctgc cttcaagtac ttcgacacca ccattgacag 6060gaagagatac
acctccacca aggaggtgct cgacgcaaca ctcatccacc aatccatcac
6120cggcctctat gaaacaagga ttgacttgtc ccagctggga ggcgactcta
gagccgatcc 6180caagaagaag agaaaggtgt aggttaacct agacttgtcc
atcttctgga ttggccaact 6240taattaatgt atgaaataaa aggatgcaca
catagtgaca tgctaatcac tataatgtgg 6300gcatcaaagt tgtgtgttat
gtgtaattac tagttatctg aataaaagag aaagagatca 6360tccatatttc
ttatcctaaa tgaatgtcac gtgtctttat aattctttga tgaaccagat
6420gcatttcatt aaccaaatcc atatacatat aaatattaat catatataat
taatatcaat 6480tgggttagca aaacaaatct agtctaggtg tgttttgcga
attcgatatc aagcttatcg 6540ataccgtcga gggggggccc ggtaccggcg
cgccgttcta tagtgtcacc taaatcgtat 6600gtgtatgata cataaggtta
tgtattaatt gtagccgcgt tctaacgaca atatgtccat 6660atggtgcact
ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc
6720gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg
cttacagaca 6780agctgtgacc gtctccggga gctgcatgtg tcagaggttt
tcaccgtcat caccgaaacg 6840cgcgagacga aagggcctcg tgatacgcct
atttttatag gttaatgtca tgaccaaaat 6900cccttaacgt gagttttcgt
tccactgagc gtcagacccc gtagaaaaga tcaaaggatc 6960ttcttgagat
cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct
7020accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga
aggtaactgg 7080cttcagcaga gcgcagatac caaatactgt ccttctagtg
tagccgtagt taggccacca 7140cttcaagaac tctgtagcac cgcctacata
cctcgctctg ctaatcctgt taccagtggc 7200tgctgccagt ggcgataagt
cgtgtcttac cgggttggac tcaagacgat agttaccgga 7260taaggcgcag
cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac
7320gacctacacc gaactgagat acctacagcg tgagcattga gaaagcgcca
cgcttcccga 7380agggagaaag gcggacaggt atccggtaag cggcagggtc
ggaacaggag agcgcacgag 7440ggagcttcca gggggaaacg cctggtatct
ttatagtcct gtcgggtttc gccacctctg 7500acttgagcgt cgatttttgt
gatgctcgtc aggggggcgg agcctatgga aaaacgccag 7560caacgcggcc
tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc
7620tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag
ctgataccgc 7680tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc
gaggaagcgg aagagcgccc 7740aatacgcaaa ccgcctctcc ccgcgcgttg
gccgattcat taatgcaggt tgatcagatc 7800tcgatcccgc gaaattaata
cgactcacta tagggagacc acaacggttt ccctctagaa 7860ataattttgt
ttaactttaa gaaggagata tacccatgga aaagcctgaa ctcaccgcga
7920cgtctgtcga gaagtttctg atcgaaaagt tcgacagcgt ctccgacctg
atgcagctct 7980cggagggcga agaatctcgt gctttcagct tcgatgtagg
agggcgtgga tatgtcctgc 8040gggtaaatag ctgcgccgat ggtttctaca
aagatcgtta tgtttatcgg cactttgcat 8100cggccgcgct cccgattccg
gaagtgcttg acattgggga attcagcgag agcctgacct 8160attgcatctc
ccgccgtgca cagggtgtca cgttgcaaga cctgcctgaa accgaactgc
8220ccgctgttct gcagccggtc gcggaggcta tggatgcgat cgctgcggcc
gatcttagcc 8280agacgagcgg gttcggccca ttcggaccgc aaggaatcgg
tcaatacact acatggcgtg 8340atttcatatg cgcgattgct gatccccatg
tgtatcactg gcaaactgtg atggacgaca 8400ccgtcagtgc gtccgtcgcg
caggctctcg atgagctgat gctttgggcc gaggactgcc 8460ccgaagtccg
gcacctcgtg cacgcggatt tcggctccaa caatgtcctg acggacaatg
8520gccgcataac agcggtcatt gactggagcg aggcgatgtt cggggattcc
caatacgagg 8580tcgccaacat cttcttctgg aggccgtggt tggcttgtat
ggagcagcag acgcgctact 8640tcgagcggag gcatccggag cttgcaggat
cgccgcggct ccgggcgtat atgctccgca 8700ttggtcttga ccaactctat
cagagcttgg ttgacggcaa tttcgatgat gcagcttggg 8760cgcagggtcg
atgcgacgca atcgtccgat ccggagccgg gactgtcggg cgtacacaaa
8820tcgcccgcag aagcgcggcc gtctggaccg atggctgtgt agaagtactc
gccgatagtg 8880gaaaccgacg ccccagcact cgtccgaggg caaaggaata
gtgaggtaca gcttggatcg 8940atccggctgc taacaaagcc cgaaaggaag
ctgagttggc tgctgccacc gctgagcaat 9000aactagcata accccttggg
gcctctaaac gggtcttgag gggttttttg ctgaaaggag 9060gaactatatc
cggatgatcg ggcgcgccgg tac 90934721357DNAArtificial sequenceRTW1013A
472ctagaagata aaccctcccc caaaacacaa attagaatga catttcaagt
tccatgtatg 60tcactttcat tctattattt ttacaacttt tagttactta acagatgtct
tgttcagcat 120aaattataat ttattctgtt tttttttagg gaacaactgt
tgtagacaac ttgttgtata 180gtgaggatat tcattacatg cttggtgcat
taaggaccct tggactgcgt gtggaagatg 240acaaaacaac caaacaagca
attgttgaag gctgtggggg attgtttccc actagtaagg 300aatctaaaga
tgaaatcaat ttattccttg gaaatgctgg tattgcaatg agatctttga
360cagcagctgt tgttgctgca ggtggaaatg caaggtctgt tttttttttt
tttgttcagc 420ataatctttg aattgttcct cgtataacta atcacaacag
agtacgtgtt cttcttcctg 480ttataatcta aaaatctcat ccagattagt
catcctttct tcttaaaagg aacctttaat 540tatcaatgta tttatttaat
atttaaatta gcttgtcaaa gtctagcata tacatatttt 600gattatattc
tgagaaatgc acctgagggt gttcctcatg atctacttca acctctgtta
660ttattagatt ttctatcatg attactggtt tgagtctcta agtagaccat
cttgatgttc 720aaaatatttc agctacgtac ttgatggggt gccccgaatg
agagagaggc caattgggga 780tttggttgct ggtcttaagc aacttggtgc
agatgttgat tgctttcttg gcacaaactg 840tccacctgtt cgtgtaaatg
ggaagggagg acttcctggc ggaaaggtat ggtttggatt 900tcatttagaa
taaggtggag taactttcct ggatcaaaat tctaatttaa gaagcctccc
960tgttttcctc tctttagaat aagactaagg gtaggtttag gagttgggtt
ttggagagaa 1020atggaaggga gagcaatttt tttcttcttc taataaatat
tctttaattt gatacatttt 1080ttaagtaaaa gaatataaag atagattagc
ataacttaat gttttaatct tttatttatt 1140tttataaata ttatatacct
gtctatttaa aaatcaaata tttgtcctcc attccctttc 1200ccttcaaaac
ctcagttcca aatataccgt agttgaatta tattttggaa ggcctattgg
1260ttggagactt ttccttttca gagattatcc ctcaccttta ttatagcctt
tctattttta 1320aacttcatat agacgccatt cttggggcgg ccgcgat
13574731357DNAArtificial sequenceRTW1012A 473ctagaagata aaccctcccc
caaaacacaa attagaatga catttcaagt tccatgtatg 60tcactttcat tctattattt
ttacaacttt tagttactta acagatgtct tgttcagcat 120aaattataat
ttattctgtt tttttttagg gaacaactgt tgtagacaac ttgttgtata
180gtgaggatat tcattacatg cttggtgcat taaggaccct tggactgcgt
gtggaagatg 240acaaaacaac caaacaagca attgttgaag gctgtggggg
attgtttccc actagtaagg 300aatctaaaga tgaaatcaat ttattccttg
gaaatgctgg tattgcaatg agatctttga 360cagcagctgt ggttgctgca
ggtggaaatg caaggtctgt tttttttttt tttgttcagc 420ataatctttg
aattgttcct cgtataacta atcacaacag agtacgtgtt cttcttcctg
480ttataatcta aaaatctcat ccagattagt catcctttct tcttaaaagg
aacctttaat 540tatcaatgta tttatttaat atttaaatta gcttgtcaaa
gtctagcata tacatatttt 600gattatattc tgagaaatgc acctgagggt
gttcctcatg atctacttca acctctgtta 660ttattagatt ttctatcatg
attactggtt tgagtctcta agtagaccat cttgatgttc 720aaaatatttc
agctacgtac ttgatggggt gccccgaatg agagagaggc caattgggga
780tttggttgct ggtcttaagc aacttggtgc agatgttgat tgctttcttg
gcacaaactg 840tccacctgtt cgtgtaaatg ggaagggagg acttcctggc
ggaaaggtat ggtttggatt 900tcatttagaa taaggtggag taactttcct
ggatcaaaat tctaatttaa gaagcctccc 960tgttttcctc tctttagaat
aagactaagg gtaggtttag gagttgggtt ttggagagaa 1020atggaaggga
gagcaatttt tttcttcttc taataaatat tctttaattt gatacatttt
1080ttaagtaaaa gaatataaag atagattagc ataacttaat gttttaatct
tttatttatt 1140tttataaata ttatatacct gtctatttaa aaatcaaata
tttgtcctcc attccctttc 1200ccttcaaaac ctcagttcca aatataccgt
agttgaatta tattttggaa ggcctattgg 1260ttggagactt ttccttttca
gagattatcc ctcaccttta ttatagcctt tctattttta 1320aacttcatat
agacgccatt cttggggcgg ccgcgat 135747430DNAArtificial
sequenceprimer, soy1-F1 474ccactagtaa ggaatctaaa gatgaaatca
3047524DNAArtificial sequenceprimer, soy1-R2 475cctgcagcaa
ccacagctgc tgtc 2447615DNAArtificial sequenceprobe, soy1-T1(FAM-MGB
476ctgcaatgcg tcctt 1547719DNAArtificial sequenceprimer, cas9-F
477ccttcttcca ccgccttga 1947821DNAArtificial sequenceprimer, Cas9-R
478tgggtgtctc tcgtgctttt t 2147919DNAArtificial sequenceprobe,
Cas9-T(FAM-MGB) 479aatcattcct ggtggagga 1948025DNAArtificial
sequenceprimer, pINII-99F 480tgatgcccac attatagtga ttagc
2548122DNAArtificial sequenceprimer, pINII-13R 481catcttctgg
attggccaac tt 2248217DNAArtificial sequenceprobe,
pINII-69T(FAM-MGB) 482actatgtgtg catcctt 1748323DNAArtificial
sequenceprimer, SIP-130F 483ttcaagttgg gctttttcag aag
2348422DNAArtificial sequenceprimer, SIP-198R 484tctccttggt
gctctcatca ca 2248515DNAArtificial sequenceprobe, SIP-170T(VIC-MGB)
485ctgcagcaga accaa 1548624DNAArtificialWOL569, Forward_primer
486ggacccatta ggtgagagcg tggg 2448719DNAArtificialWOL876,
Reverse_primer 487cagctgctgt caaagatct 1948829DNAArtificialWOL570,
Reverse_primer 488tctaataata acagaggttg aagtagatc
294894104DNAGlycine max 489atggacaaaa agtactcaat agggctcgac
atagggacta actccgttgg atgggccgtc 60atcaccgacg agtacaaggt gccctccaag
aagttcaagg tgttgggaaa caccgacagg 120cacagcataa agaagaattt
gatcggtgcc ctcctcttcg actccggaga gaccgctgag 180gctaccaggc
tcaagaggac cgctagaagg cgctacacca gaaggaagaa cagaatctgc
240tacctgcagg agatcttctc caacgagatg gccaaggtgg acgactcctt
cttccaccgc 300cttgaggaat cattcctggt ggaggaggat aaaaagcacg
agagacaccc aatcttcggg 360aacatcgtcg acgaggtggc ctaccatgaa
aagtacccta ccatctacca cctgaggaag 420aagctggtcg actctaccga
caaggctgac ttgcgcttga tttacctggc tctcgctcac 480atgataaagt
tccgcggaca cttcctcatt gagggagacc tgaacccaga caactccgac
540gtggacaagc tcttcatcca gctcgttcag acctacaacc agcttttcga
ggagaaccca 600atcaacgcca gtggagttga cgccaaggct atcctctctg
ctcgtctgtc aaagtccagg 660aggcttgaga acttgattgc ccagctgcct
ggcgaaaaga agaacggact gttcggaaac 720ttgatcgctc tctccctggg
attgactccc aacttcaagt ccaacttcga cctcgccgag 780gacgctaagt
tgcagttgtc taaagacacc tacgacgatg acctcgacaa cttgctggcc
840cagataggcg accaatacgc cgatctcttc ctcgccgcta agaacttgtc
cgacgcaatc 900ctgctgtccg acatcctgag agtcaacact gagattacca
aagctcctct gtctgcttcc 960atgattaagc gctacgacga gcaccaccaa
gatctgaccc tgctcaaggc cctggtgaga 1020cagcagctgc ccgagaagta
caaggagatc tttttcgacc agtccaagaa cggctacgcc 1080ggatacattg
acggaggcgc ctcccaggaa gagttctaca agttcatcaa gcccatcctt
1140gagaagatgg acggtaccga ggagctgttg gtgaagttga acagagagga
cctgttgagg 1200aagcagagaa ccttcgacaa cggaagcatc cctcaccaaa
tccacctggg agagctccac 1260gccatcttga ggaggcagga ggatttctat
cccttcctga aggacaaccg cgagaagatt 1320gagaagatct tgaccttcag
aattccttac tacgtcgggc cactcgccag aggaaactct 1380aggttcgcct
ggatgacccg caaatctgaa gagaccatta ctccctggaa cttcgaggaa
1440gtcgtggaca agggcgcttc cgctcagtct ttcatcgaga ggatgaccaa
cttcgataaa 1500aatctgccca acgagaaggt gctgcccaag cactccctgt
tgtacgagta tttcacagtg 1560tacaacgagc tcaccaaggt gaagtacgtc
acagagggaa tgaggaagcc tgccttcttg 1620tccggagagc agaagaaggc
catcgtcgac ctgctcttca agaccaacag gaaggtgact 1680gtcaagcagc
tgaaggagga ctacttcaag aagatcgagt gcttcgactc cgtcgagatc
1740tctggtgtcg aggacaggtt caacgcctcc cttgggactt accacgatct
gctcaagatt 1800attaaagaca aggacttcct ggacaacgag gagaacgagg
acatccttga ggacatcgtg 1860ctcaccctga ccttgttcga agacagggaa
atgatcgaag agaggctcaa gacctacgcc 1920cacctcttcg acgacaaggt
gatgaaacag ctgaagagac gcagatatac cggctgggga 1980aggctctccc
gcaaattgat caacgggatc agggacaagc agtcagggaa gactatactc
2040gacttcctga agtccgacgg attcgccaac aggaacttca tgcagctcat
tcacgacgac 2100tccttgacct tcaaggagga catccagaag gctcaggtgt
ctggacaggg tgactccttg 2160catgagcaca ttgctaactt ggccggctct
cccgctatta agaagggcat tttgcagacc 2220gtgaaggtcg ttgacgagct
cgtgaaggtg atgggacgcc acaagccaga gaacatcgtt 2280attgagatgg
ctcgcgagaa ccaaactacc cagaaagggc agaagaattc ccgcgagagg
2340atgaagcgca ttgaggaggg cataaaagag cttggctctc agatcctcaa
ggagcacccc 2400gtcgagaaca ctcagctgca gaacgagaag ctgtacctgt
actacctcca aaacggaagg 2460gacatgtacg tggaccagga gctggacatc
aacaggttgt ccgactacga cgtcgaccac 2520atcgtgcctc agtccttcct
gaaggatgac tccatcgaca ataaagtgct gacacgctcc 2580gataaaaata
gaggcaagtc cgacaacgtc ccctccgagg aggtcgtgaa gaagatgaaa
2640aactactgga gacagctctt gaacgccaag ctcatcaccc agcgtaagtt
cgacaacctg 2700actaaggctg agagaggagg attgtccgag ctcgataagg
ccggattcat caagagacag 2760ctcgtcgaaa cccgccaaat taccaagcac
gtggcccaaa ttctggattc ccgcatgaac 2820accaagtacg atgaaaatga
caagctgatc cgcgaggtca aggtgatcac cttgaagtcc 2880aagctggtct
ccgacttccg caaggacttc cagttctaca aggtgaggga gatcaacaac
2940taccaccacg cacacgacgc ctacctcaac gctgtcgttg gaaccgccct
catcaaaaaa 3000tatcctaagc tggagtctga gttcgtctac ggcgactaca
aggtgtacga cgtgaggaag 3060atgatcgcta agtctgagca ggagatcggc
aaggccaccg ccaagtactt cttctactcc 3120aacatcatga acttcttcaa
gaccgagatc actctcgcca acggtgagat caggaagcgc 3180ccactgatcg
agaccaacgg tgagactgga gagatcgtgt gggacaaagg gagggatttc
3240gctactgtga ggaaggtgct ctccatgcct caggtgaaca tcgtcaagaa
gaccgaagtt 3300cagaccggag gattctccaa ggagtccatc ctccccaaga
gaaactccga caagctgatc 3360gctagaaaga aagactggga ccctaagaag
tacggaggct tcgattctcc taccgtggcc 3420tactctgtgc tggtcgtggc
caaggtggag aagggcaagt ccaagaagct gaaatccgtc 3480aaggagctcc
tcgggattac catcatggag aggagttcct tcgagaagaa ccctatcgac
3540ttcctggagg ccaagggata taaagaggtg aagaaggacc tcatcatcaa
gctgcccaag 3600tactccctct tcgagttgga gaacggaagg aagaggatgc
tggcttctgc cggagagttg 3660cagaagggaa atgagctcgc ccttccctcc
aagtacgtga acttcctgta cctcgcctct 3720cactatgaaa agttgaaggg
ctctcctgag gacaacgagc agaagcagct cttcgtggag 3780cagcacaagc
actacctgga cgaaattatc gagcagatct ctgagttctc caagcgcgtg
3840atattggccg acgccaacct cgacaaggtg ctgtccgcct acaacaagca
cagggataag 3900cccattcgcg agcaggctga aaacattatc cacctgttta
ccctcacaaa cttgggagcc 3960cctgctgcct tcaagtactt cgacaccacc
attgacagga agagatacac ctccaccaag 4020gaggtgctcg acgcaacact
catccaccaa tccatcaccg gcctctatga aacaaggatt 4080gacttgtccc
agctgggagg cgac 410449023DNAGlycine max 490gtttgtttgt tgttgggtgt
ggg 2349122DNAGlycine max 491tgttgttggg tgtgggaata gg
224929174DNAArtificial sequenceRTW1199 492ccgggtgtga tttagtataa
agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta 60cctagtaata agtaatattg
aacaaaataa atggtaaagt gtcagatata taaaataggc 120tttaataaaa
ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt
180catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat
acattaaaaa 240atacttggat ctttctctta ccctgtttat attgagacct
gaaacttgag agagatacac 300taatcttgcc ttgttgtttc attccctaac
ttacaggact cagcgcatgt catgtggtct 360cgttccccat ttaagtccca
caccgtctaa acttattaaa ttattaatgt ttataactag 420atgcacaaca
acaaagcttg tttgtttgtt gttgggtgtg ttttagagct agaaatagca
480agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc
ggtgcttttt 540tttgcggccg caattggatc gggtttactt attttgtggg
tatctatact tttattagat 600ttttaatcag gctcctgatt tctttttatt
tcgattgaat tcctgaactt gtattattca 660gtagatcgaa taaattataa
aaagataaaa tcataaaata atattttatc ctatcaatca 720tattaaagca
atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt
780tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt
attactttta 840aaaaaatcat aaaggtttag tattttttta aaataaatat
aggaatagtt ttactattca 900ctgctttaat agaaaaatag tttaaaattt
aagatagttt taatcccagc atttgccacg 960tttgaacgtg agccgaaacg
atgtcgttac attatcttaa cctagctgaa acgatgtcgt 1020cataatatcg
ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg
1080aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct
caatcccacg 1140cgagtagagc acagtaacct tcaaataagc gaatggggca
taatcagaaa tccgaaataa 1200acctaggggc attatcggaa atgaaaagta
gctcactcaa tataaaaatc taggaaccct 1260agttttcgtt atcactctgt
gctccctcgc tctatttctc agtctctgtg tttgcggctg 1320aggattccga
acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc
1380tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg
ttatgttttt 1440ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt
cgctttgttt ttgtggttca 1500gttttttagg attcttttgg tttttgaatc
gattaatcgg aagagatttt cgagttattt 1560ggtgtgttgg aggtgaatct
tttttttgag gtcatagatc tgttgtattt gtgttataaa 1620catgcgactt
tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc
1680tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag
gtttgtttta 1740acaggattaa aagtttttta agcatgttga aggagtcttg
tagatatgta accgtcgata 1800gtttttttgt gggtttgttc acatgttatc
aagcttaatc ttttactatg tatgcgacca 1860tatctggatc cagcaaaggc
gattttttaa ttccttgtga aacttttgta atatgaagtt 1920gaaattttgt
tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta
1980tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta
tttctttgaa 2040ttgattctag tttaagtaat ccatggcacc gaagaagaag
cgcaaggtga tggacaaaaa 2100gtactcaata gggctcgaca tagggactaa
ctccgttgga tgggccgtca tcaccgacga 2160gtacaaggtg ccctccaaga
agttcaaggt gttgggaaac accgacaggc acagcataaa 2220gaagaatttg
atcggtgccc tcctcttcga ctccggagag accgctgagg ctaccaggct
2280caagaggacc gctagaaggc gctacaccag aaggaagaac agaatctgct
acctgcagga 2340gatcttctcc aacgagatgg ccaaggtgga cgactccttc
ttccaccgcc ttgaggaatc 2400attcctggtg gaggaggata aaaagcacga
gagacaccca atcttcggga acatcgtcga 2460cgaggtggcc taccatgaaa
agtaccctac catctaccac ctgaggaaga agctggtcga 2520ctctaccgac
aaggctgact tgcgcttgat ttacctggct ctcgctcaca tgataaagtt
2580ccgcggacac ttcctcattg agggagacct gaacccagac aactccgacg
tggacaagct 2640cttcatccag ctcgttcaga cctacaacca gcttttcgag
gagaacccaa tcaacgccag 2700tggagttgac gccaaggcta tcctctctgc
tcgtctgtca aagtccagga ggcttgagaa 2760cttgattgcc cagctgcctg
gcgaaaagaa gaacggactg ttcggaaact tgatcgctct 2820ctccctggga
ttgactccca acttcaagtc caacttcgac ctcgccgagg acgctaagtt
2880gcagttgtct aaagacacct acgacgatga cctcgacaac ttgctggccc
agataggcga 2940ccaatacgcc gatctcttcc tcgccgctaa gaacttgtcc
gacgcaatcc tgctgtccga 3000catcctgaga gtcaacactg agattaccaa
agctcctctg tctgcttcca tgattaagcg 3060ctacgacgag caccaccaag
atctgaccct gctcaaggcc ctggtgagac agcagctgcc 3120cgagaagtac
aaggagatct ttttcgacca gtccaagaac ggctacgccg gatacattga
3180cggaggcgcc tcccaggaag agttctacaa gttcatcaag cccatccttg
agaagatgga 3240cggtaccgag gagctgttgg tgaagttgaa cagagaggac
ctgttgagga agcagagaac 3300cttcgacaac ggaagcatcc ctcaccaaat
ccacctggga gagctccacg ccatcttgag 3360gaggcaggag gatttctatc
ccttcctgaa ggacaaccgc gagaagattg agaagatctt 3420gaccttcaga
attccttact acgtcgggcc actcgccaga ggaaactcta ggttcgcctg
3480gatgacccgc aaatctgaag agaccattac tccctggaac ttcgaggaag
tcgtggacaa 3540gggcgcttcc gctcagtctt tcatcgagag gatgaccaac
ttcgataaaa atctgcccaa 3600cgagaaggtg ctgcccaagc actccctgtt
gtacgagtat ttcacagtgt acaacgagct 3660caccaaggtg aagtacgtca
cagagggaat gaggaagcct gccttcttgt ccggagagca 3720gaagaaggcc
atcgtcgacc tgctcttcaa gaccaacagg aaggtgactg tcaagcagct
3780gaaggaggac tacttcaaga agatcgagtg cttcgactcc gtcgagatct
ctggtgtcga 3840ggacaggttc aacgcctccc ttgggactta ccacgatctg
ctcaagatta ttaaagacaa 3900ggacttcctg gacaacgagg agaacgagga
catccttgag gacatcgtgc tcaccctgac 3960cttgttcgaa gacagggaaa
tgatcgaaga gaggctcaag acctacgccc acctcttcga 4020cgacaaggtg
atgaaacagc tgaagagacg cagatatacc ggctggggaa ggctctcccg
4080caaattgatc aacgggatca gggacaagca gtcagggaag actatactcg
acttcctgaa 4140gtccgacgga ttcgccaaca ggaacttcat gcagctcatt
cacgacgact ccttgacctt 4200caaggaggac atccagaagg ctcaggtgtc
tggacagggt gactccttgc atgagcacat 4260tgctaacttg gccggctctc
ccgctattaa gaagggcatt ttgcagaccg tgaaggtcgt 4320tgacgagctc
gtgaaggtga tgggacgcca caagccagag aacatcgtta ttgagatggc
4380tcgcgagaac caaactaccc agaaagggca gaagaattcc cgcgagagga
tgaagcgcat 4440tgaggagggc ataaaagagc ttggctctca gatcctcaag
gagcaccccg tcgagaacac 4500tcagctgcag aacgagaagc tgtacctgta
ctacctccaa aacggaaggg acatgtacgt 4560ggaccaggag ctggacatca
acaggttgtc cgactacgac gtcgaccaca tcgtgcctca 4620gtccttcctg
aaggatgact ccatcgacaa taaagtgctg acacgctccg ataaaaatag
4680aggcaagtcc gacaacgtcc cctccgagga ggtcgtgaag aagatgaaaa
actactggag 4740acagctcttg aacgccaagc tcatcaccca gcgtaagttc
gacaacctga ctaaggctga 4800gagaggagga ttgtccgagc tcgataaggc
cggattcatc aagagacagc tcgtcgaaac 4860ccgccaaatt accaagcacg
tggcccaaat tctggattcc cgcatgaaca ccaagtacga 4920tgaaaatgac
aagctgatcc gcgaggtcaa ggtgatcacc ttgaagtcca agctggtctc
4980cgacttccgc aaggacttcc agttctacaa ggtgagggag atcaacaact
accaccacgc 5040acacgacgcc tacctcaacg ctgtcgttgg aaccgccctc
atcaaaaaat atcctaagct 5100ggagtctgag ttcgtctacg gcgactacaa
ggtgtacgac gtgaggaaga tgatcgctaa 5160gtctgagcag gagatcggca
aggccaccgc caagtacttc ttctactcca acatcatgaa 5220cttcttcaag
accgagatca ctctcgccaa cggtgagatc aggaagcgcc cactgatcga
5280gaccaacggt gagactggag agatcgtgtg ggacaaaggg agggatttcg
ctactgtgag 5340gaaggtgctc tccatgcctc aggtgaacat cgtcaagaag
accgaagttc agaccggagg 5400attctccaag gagtccatcc tccccaagag
aaactccgac aagctgatcg ctagaaagaa 5460agactgggac cctaagaagt
acggaggctt cgattctcct accgtggcct actctgtgct 5520ggtcgtggcc
aaggtggaga agggcaagtc caagaagctg aaatccgtca aggagctcct
5580cgggattacc atcatggaga ggagttcctt cgagaagaac cctatcgact
tcctggaggc 5640caagggatat aaagaggtga agaaggacct catcatcaag
ctgcccaagt actccctctt 5700cgagttggag aacggaagga agaggatgct
ggcttctgcc ggagagttgc agaagggaaa 5760tgagctcgcc cttccctcca
agtacgtgaa cttcctgtac ctcgcctctc actatgaaaa 5820gttgaagggc
tctcctgagg acaacgagca gaagcagctc ttcgtggagc agcacaagca
5880ctacctggac gaaattatcg agcagatctc tgagttctcc aagcgcgtga
tattggccga 5940cgccaacctc gacaaggtgc tgtccgccta caacaagcac
agggataagc ccattcgcga 6000gcaggctgaa aacattatcc acctgtttac
cctcacaaac ttgggagccc ctgctgcctt 6060caagtacttc gacaccacca
ttgacaggaa gagatacacc tccaccaagg aggtgctcga 6120cgcaacactc
atccaccaat ccatcaccgg cctctatgaa acaaggattg acttgtccca
6180gctgggaggc gactctagag ccgatcccaa gaagaagaga aaggtgaaga
gaccacggga 6240ccgccacgat ggcgagctgg gaggccgcaa gcgggcaagg
taggttaacc tagacttgtc 6300catcttctgg attggccaac ttaattaatg
tatgaaataa aaggatgcac acatagtgac 6360atgctaatca ctataatgtg
ggcatcaaag ttgtgtgtta tgtgtaatta ctagttatct 6420gaataaaaga
gaaagagatc atccatattt cttatcctaa atgaatgtca cgtgtcttta
6480taattctttg atgaaccaga tgcatttcat taaccaaatc catatacata
taaatattaa 6540tcatatataa ttaatatcaa ttgggttagc aaaacaaatc
tagtctaggt gtgttttgcg 6600aattcgatat caagcttatc gataccgtcg
agggggggcc cggtaccggc gcgccgttct 6660atagtgtcac ctaaatcgta
tgtgtatgat acataaggtt atgtattaat tgtagccgcg 6720ttctaacgac
aatatgtcca tatggtgcac tctcagtaca atctgctctg atgccgcata
6780gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg
cttgtctgct 6840cccggcatcc gcttacagac aagctgtgac cgtctccggg
agctgcatgt gtcagaggtt 6900ttcaccgtca tcaccgaaac gcgcgagacg
aaagggcctc gtgatacgcc tatttttata 6960ggttaatgtc atgaccaaaa
tcccttaacg tgagttttcg ttccactgag cgtcagaccc 7020cgtagaaaag
atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt
7080gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag
agctaccaac 7140tctttttccg aaggtaactg gcttcagcag agcgcagata
ccaaatactg ttcttctagt 7200gtagccgtag ttaggccacc acttcaagaa
ctctgtagca ccgcctacat acctcgctct 7260gctaatcctg ttaccagtgg
ctgctgccag tggcgataag tcgtgtctta ccgggttgga 7320ctcaagacga
tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac
7380acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc
gtgagctatg 7440agaaagcgcc acgcttcccg aagggagaaa ggcggacagg
tatccggtaa gcggcagggt 7500cggaacagga gagcgcacga gggagcttcc
agggggaaac gcctggtatc tttatagtcc 7560tgtcgggttt cgccacctct
gacttgagcg tcgatttttg tgatgctcgt caggggggcg 7620gagcctatgg
aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc
7680ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc
gtattaccgc 7740ctttgagtga gctgataccg ctcgccgcag ccgaacgacc
gagcgcagcg agtcagtgag 7800cgaggaagcg gaagagcgcc caatacgcaa
accgcctctc cccgcgcgtt ggccgattca 7860ttaatgcagg ttgatcagat
ctcgatcccg cgaaattaat acgactcact atagggagac 7920cacaacggtt
tccctctaga aataattttg tttaacttta agaaggagat atacccatgg
7980aaaagcctga actcaccgcg acgtctgtcg agaagtttct gatcgaaaag
ttcgacagcg 8040tctccgacct gatgcagctc tcggagggcg aagaatctcg
tgctttcagc ttcgatgtag 8100gagggcgtgg atatgtcctg cgggtaaata
gctgcgccga tggtttctac aaagatcgtt 8160atgtttatcg gcactttgca
tcggccgcgc tcccgattcc ggaagtgctt gacattgggg 8220aattcagcga
gagcctgacc tattgcatct cccgccgtgc acagggtgtc acgttgcaag
8280acctgcctga aaccgaactg cccgctgttc tgcagccggt cgcggaggct
atggatgcga 8340tcgctgcggc cgatcttagc cagacgagcg ggttcggccc
attcggaccg caaggaatcg 8400gtcaatacac tacatggcgt gatttcatat
gcgcgattgc tgatccccat gtgtatcact 8460ggcaaactgt gatggacgac
accgtcagtg cgtccgtcgc gcaggctctc gatgagctga 8520tgctttgggc
cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat ttcggctcca
8580acaatgtcct gacggacaat ggccgcataa cagcggtcat tgactggagc
gaggcgatgt 8640tcggggattc ccaatacgag gtcgccaaca tcttcttctg
gaggccgtgg ttggcttgta 8700tggagcagca gacgcgctac ttcgagcgga
ggcatccgga gcttgcagga tcgccgcggc 8760tccgggcgta tatgctccgc
attggtcttg accaactcta tcagagcttg gttgacggca 8820atttcgatga
tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga tccggagccg
8880ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc cgtctggacc
gatggctgtg 8940tagaagtact cgccgatagt ggaaaccgac gccccagcac
tcgtccgagg gcaaaggaat 9000agtgaggtac agcttggatc gatccggctg
ctaacaaagc ccgaaaggaa gctgagttgg 9060ctgctgccac cgctgagcaa
taactagcat aaccccttgg ggcctctaaa cgggtcttga 9120ggggtttttt
gctgaaagga ggaactatat ccggatgctc gggcgcgccg gtac
91744939174DNAArtificial sequenceRTW1200 493ccgggtgtga tttagtataa
agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta 60cctagtaata agtaatattg
aacaaaataa atggtaaagt gtcagatata taaaataggc 120tttaataaaa
ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt
180catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat
acattaaaaa 240atacttggat ctttctctta ccctgtttat attgagacct
gaaacttgag agagatacac 300taatcttgcc ttgttgtttc attccctaac
ttacaggact cagcgcatgt catgtggtct 360cgttccccat ttaagtccca
caccgtctaa acttattaaa ttattaatgt ttataactag 420atgcacaaca
acaaagcttg tgttgttggg tgtgggaatg ttttagagct agaaatagca
480agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc
ggtgcttttt 540tttgcggccg caattggatc gggtttactt attttgtggg
tatctatact tttattagat 600ttttaatcag gctcctgatt tctttttatt
tcgattgaat tcctgaactt gtattattca 660gtagatcgaa taaattataa
aaagataaaa tcataaaata atattttatc ctatcaatca 720tattaaagca
atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt
780tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt
attactttta 840aaaaaatcat aaaggtttag tattttttta aaataaatat
aggaatagtt ttactattca 900ctgctttaat agaaaaatag tttaaaattt
aagatagttt taatcccagc atttgccacg 960tttgaacgtg agccgaaacg
atgtcgttac attatcttaa cctagctgaa acgatgtcgt 1020cataatatcg
ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg
1080aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct
caatcccacg 1140cgagtagagc acagtaacct tcaaataagc gaatggggca
taatcagaaa tccgaaataa 1200acctaggggc attatcggaa atgaaaagta
gctcactcaa tataaaaatc taggaaccct 1260agttttcgtt atcactctgt
gctccctcgc tctatttctc agtctctgtg tttgcggctg 1320aggattccga
acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc
1380tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg
ttatgttttt 1440ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt
cgctttgttt ttgtggttca 1500gttttttagg attcttttgg tttttgaatc
gattaatcgg aagagatttt cgagttattt 1560ggtgtgttgg aggtgaatct
tttttttgag gtcatagatc tgttgtattt gtgttataaa 1620catgcgactt
tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc
1680tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag
gtttgtttta 1740acaggattaa aagtttttta agcatgttga aggagtcttg
tagatatgta accgtcgata 1800gtttttttgt gggtttgttc acatgttatc
aagcttaatc ttttactatg tatgcgacca 1860tatctggatc cagcaaaggc
gattttttaa ttccttgtga aacttttgta atatgaagtt 1920gaaattttgt
tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta
1980tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta
tttctttgaa 2040ttgattctag tttaagtaat ccatggcacc gaagaagaag
cgcaaggtga tggacaaaaa 2100gtactcaata gggctcgaca tagggactaa
ctccgttgga tgggccgtca tcaccgacga 2160gtacaaggtg ccctccaaga
agttcaaggt gttgggaaac accgacaggc acagcataaa 2220gaagaatttg
atcggtgccc tcctcttcga ctccggagag accgctgagg ctaccaggct
2280caagaggacc gctagaaggc gctacaccag aaggaagaac agaatctgct
acctgcagga 2340gatcttctcc aacgagatgg ccaaggtgga cgactccttc
ttccaccgcc ttgaggaatc 2400attcctggtg gaggaggata aaaagcacga
gagacaccca atcttcggga acatcgtcga 2460cgaggtggcc taccatgaaa
agtaccctac catctaccac ctgaggaaga agctggtcga 2520ctctaccgac
aaggctgact tgcgcttgat ttacctggct ctcgctcaca tgataaagtt
2580ccgcggacac ttcctcattg agggagacct gaacccagac aactccgacg
tggacaagct 2640cttcatccag ctcgttcaga cctacaacca gcttttcgag
gagaacccaa tcaacgccag 2700tggagttgac gccaaggcta tcctctctgc
tcgtctgtca aagtccagga ggcttgagaa 2760cttgattgcc cagctgcctg
gcgaaaagaa gaacggactg ttcggaaact tgatcgctct 2820ctccctggga
ttgactccca acttcaagtc caacttcgac ctcgccgagg acgctaagtt
2880gcagttgtct aaagacacct acgacgatga cctcgacaac ttgctggccc
agataggcga 2940ccaatacgcc gatctcttcc tcgccgctaa gaacttgtcc
gacgcaatcc tgctgtccga 3000catcctgaga gtcaacactg agattaccaa
agctcctctg tctgcttcca tgattaagcg 3060ctacgacgag caccaccaag
atctgaccct gctcaaggcc ctggtgagac agcagctgcc 3120cgagaagtac
aaggagatct ttttcgacca gtccaagaac ggctacgccg gatacattga
3180cggaggcgcc tcccaggaag agttctacaa gttcatcaag cccatccttg
agaagatgga 3240cggtaccgag gagctgttgg tgaagttgaa cagagaggac
ctgttgagga agcagagaac 3300cttcgacaac ggaagcatcc ctcaccaaat
ccacctggga gagctccacg ccatcttgag 3360gaggcaggag gatttctatc
ccttcctgaa ggacaaccgc gagaagattg agaagatctt 3420gaccttcaga
attccttact acgtcgggcc actcgccaga ggaaactcta ggttcgcctg
3480gatgacccgc aaatctgaag agaccattac tccctggaac ttcgaggaag
tcgtggacaa 3540gggcgcttcc gctcagtctt tcatcgagag gatgaccaac
ttcgataaaa atctgcccaa 3600cgagaaggtg ctgcccaagc actccctgtt
gtacgagtat ttcacagtgt acaacgagct 3660caccaaggtg aagtacgtca
cagagggaat gaggaagcct gccttcttgt ccggagagca 3720gaagaaggcc
atcgtcgacc tgctcttcaa gaccaacagg aaggtgactg tcaagcagct
3780gaaggaggac tacttcaaga agatcgagtg cttcgactcc gtcgagatct
ctggtgtcga 3840ggacaggttc aacgcctccc ttgggactta ccacgatctg
ctcaagatta ttaaagacaa 3900ggacttcctg gacaacgagg agaacgagga
catccttgag gacatcgtgc tcaccctgac 3960cttgttcgaa gacagggaaa
tgatcgaaga gaggctcaag acctacgccc acctcttcga 4020cgacaaggtg
atgaaacagc tgaagagacg cagatatacc ggctggggaa ggctctcccg
4080caaattgatc aacgggatca gggacaagca gtcagggaag actatactcg
acttcctgaa 4140gtccgacgga ttcgccaaca ggaacttcat gcagctcatt
cacgacgact ccttgacctt 4200caaggaggac atccagaagg ctcaggtgtc
tggacagggt gactccttgc atgagcacat 4260tgctaacttg gccggctctc
ccgctattaa gaagggcatt ttgcagaccg tgaaggtcgt 4320tgacgagctc
gtgaaggtga tgggacgcca caagccagag aacatcgtta ttgagatggc
4380tcgcgagaac caaactaccc agaaagggca gaagaattcc cgcgagagga
tgaagcgcat 4440tgaggagggc ataaaagagc ttggctctca gatcctcaag
gagcaccccg tcgagaacac 4500tcagctgcag aacgagaagc tgtacctgta
ctacctccaa aacggaaggg acatgtacgt 4560ggaccaggag ctggacatca
acaggttgtc cgactacgac gtcgaccaca tcgtgcctca 4620gtccttcctg
aaggatgact ccatcgacaa taaagtgctg acacgctccg ataaaaatag
4680aggcaagtcc gacaacgtcc cctccgagga ggtcgtgaag aagatgaaaa
actactggag 4740acagctcttg aacgccaagc tcatcaccca gcgtaagttc
gacaacctga ctaaggctga 4800gagaggagga ttgtccgagc tcgataaggc
cggattcatc aagagacagc tcgtcgaaac 4860ccgccaaatt accaagcacg
tggcccaaat tctggattcc cgcatgaaca ccaagtacga 4920tgaaaatgac
aagctgatcc gcgaggtcaa ggtgatcacc ttgaagtcca agctggtctc
4980cgacttccgc aaggacttcc agttctacaa ggtgagggag atcaacaact
accaccacgc 5040acacgacgcc tacctcaacg ctgtcgttgg aaccgccctc
atcaaaaaat atcctaagct 5100ggagtctgag ttcgtctacg gcgactacaa
ggtgtacgac gtgaggaaga tgatcgctaa 5160gtctgagcag gagatcggca
aggccaccgc caagtacttc ttctactcca acatcatgaa 5220cttcttcaag
accgagatca ctctcgccaa cggtgagatc aggaagcgcc cactgatcga
5280gaccaacggt gagactggag agatcgtgtg ggacaaaggg agggatttcg
ctactgtgag 5340gaaggtgctc tccatgcctc aggtgaacat cgtcaagaag
accgaagttc agaccggagg 5400attctccaag gagtccatcc tccccaagag
aaactccgac aagctgatcg ctagaaagaa 5460agactgggac cctaagaagt
acggaggctt cgattctcct accgtggcct actctgtgct 5520ggtcgtggcc
aaggtggaga agggcaagtc caagaagctg aaatccgtca aggagctcct
5580cgggattacc atcatggaga ggagttcctt cgagaagaac cctatcgact
tcctggaggc 5640caagggatat aaagaggtga agaaggacct catcatcaag
ctgcccaagt actccctctt 5700cgagttggag aacggaagga agaggatgct
ggcttctgcc ggagagttgc agaagggaaa 5760tgagctcgcc cttccctcca
agtacgtgaa cttcctgtac ctcgcctctc actatgaaaa 5820gttgaagggc
tctcctgagg acaacgagca gaagcagctc ttcgtggagc agcacaagca
5880ctacctggac gaaattatcg agcagatctc tgagttctcc aagcgcgtga
tattggccga 5940cgccaacctc gacaaggtgc tgtccgccta caacaagcac
agggataagc ccattcgcga 6000gcaggctgaa aacattatcc acctgtttac
cctcacaaac ttgggagccc ctgctgcctt 6060caagtacttc gacaccacca
ttgacaggaa gagatacacc tccaccaagg aggtgctcga 6120cgcaacactc
atccaccaat ccatcaccgg cctctatgaa acaaggattg acttgtccca
6180gctgggaggc gactctagag ccgatcccaa gaagaagaga aaggtgaaga
gaccacggga 6240ccgccacgat ggcgagctgg gaggccgcaa gcgggcaagg
taggttaacc tagacttgtc 6300catcttctgg attggccaac ttaattaatg
tatgaaataa aaggatgcac acatagtgac 6360atgctaatca ctataatgtg
ggcatcaaag ttgtgtgtta tgtgtaatta ctagttatct 6420gaataaaaga
gaaagagatc atccatattt cttatcctaa atgaatgtca cgtgtcttta
6480taattctttg atgaaccaga tgcatttcat taaccaaatc catatacata
taaatattaa 6540tcatatataa ttaatatcaa ttgggttagc aaaacaaatc
tagtctaggt gtgttttgcg 6600aattcgatat caagcttatc gataccgtcg
agggggggcc cggtaccggc gcgccgttct 6660atagtgtcac ctaaatcgta
tgtgtatgat acataaggtt atgtattaat tgtagccgcg 6720ttctaacgac
aatatgtcca tatggtgcac tctcagtaca atctgctctg atgccgcata
6780gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg
cttgtctgct 6840cccggcatcc gcttacagac aagctgtgac cgtctccggg
agctgcatgt gtcagaggtt 6900ttcaccgtca tcaccgaaac gcgcgagacg
aaagggcctc gtgatacgcc tatttttata 6960ggttaatgtc atgaccaaaa
tcccttaacg tgagttttcg ttccactgag cgtcagaccc 7020cgtagaaaag
atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt
7080gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag
agctaccaac 7140tctttttccg aaggtaactg gcttcagcag agcgcagata
ccaaatactg ttcttctagt 7200gtagccgtag ttaggccacc acttcaagaa
ctctgtagca ccgcctacat acctcgctct 7260gctaatcctg ttaccagtgg
ctgctgccag tggcgataag tcgtgtctta ccgggttgga 7320ctcaagacga
tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac
7380acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc
gtgagctatg 7440agaaagcgcc acgcttcccg aagggagaaa ggcggacagg
tatccggtaa gcggcagggt 7500cggaacagga gagcgcacga gggagcttcc
agggggaaac gcctggtatc tttatagtcc 7560tgtcgggttt cgccacctct
gacttgagcg tcgatttttg tgatgctcgt caggggggcg 7620gagcctatgg
aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc
7680ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc
gtattaccgc 7740ctttgagtga gctgataccg ctcgccgcag ccgaacgacc
gagcgcagcg agtcagtgag 7800cgaggaagcg gaagagcgcc caatacgcaa
accgcctctc cccgcgcgtt ggccgattca 7860ttaatgcagg ttgatcagat
ctcgatcccg cgaaattaat acgactcact atagggagac 7920cacaacggtt
tccctctaga aataattttg tttaacttta agaaggagat atacccatgg
7980aaaagcctga actcaccgcg acgtctgtcg agaagtttct gatcgaaaag
ttcgacagcg 8040tctccgacct gatgcagctc tcggagggcg aagaatctcg
tgctttcagc ttcgatgtag 8100gagggcgtgg atatgtcctg cgggtaaata
gctgcgccga tggtttctac aaagatcgtt 8160atgtttatcg gcactttgca
tcggccgcgc tcccgattcc ggaagtgctt gacattgggg 8220aattcagcga
gagcctgacc tattgcatct cccgccgtgc acagggtgtc acgttgcaag
8280acctgcctga aaccgaactg cccgctgttc tgcagccggt cgcggaggct
atggatgcga 8340tcgctgcggc cgatcttagc cagacgagcg ggttcggccc
attcggaccg caaggaatcg 8400gtcaatacac tacatggcgt gatttcatat
gcgcgattgc tgatccccat gtgtatcact 8460ggcaaactgt gatggacgac
accgtcagtg cgtccgtcgc gcaggctctc gatgagctga 8520tgctttgggc
cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat ttcggctcca
8580acaatgtcct gacggacaat ggccgcataa cagcggtcat tgactggagc
gaggcgatgt 8640tcggggattc ccaatacgag gtcgccaaca tcttcttctg
gaggccgtgg ttggcttgta 8700tggagcagca gacgcgctac ttcgagcgga
ggcatccgga gcttgcagga tcgccgcggc 8760tccgggcgta tatgctccgc
attggtcttg accaactcta tcagagcttg gttgacggca 8820atttcgatga
tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga tccggagccg
8880ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc cgtctggacc
gatggctgtg 8940tagaagtact cgccgatagt ggaaaccgac gccccagcac
tcgtccgagg gcaaaggaat 9000agtgaggtac agcttggatc gatccggctg
ctaacaaagc ccgaaaggaa gctgagttgg 9060ctgctgccac cgctgagcaa
taactagcat aaccccttgg ggcctctaaa cgggtcttga 9120ggggtttttt
gctgaaagga ggaactatat ccggatgctc gggcgcgccg gtac
91744943175DNAArtificial sequenceRTW1190A 494cgaattctac aggtcactaa
taccatctaa gtagttggtt catagtgact gcatatgtaa 60aaattatcct tattttaagg
aaattaaaaa ttatcatata tatataagtt ttaaattaat 120tatcttatat
atgtaccaaa aagttttaaa gcaattatta taaaaattaa taaatttatc
180atataaaata atttataatt aaattttaaa ttatcaattc attaaattaa
attatttaaa 240atttttgaat gataatataa taattttatc ctctactaag
tcccaacgtt tcctatttta 300ttccactttt agcaataaat tttgtcataa
acacttataa caaaaaaagt aagtaaaaaa 360taaaaaaaag tttttcaata
aagtataaac taatttgtat aaacttttag aaaaaataaa 420gttatacatt
gataatataa attttttaca taattatccg atcaactcat tatatatgat
480aaatttattg attttttaaa ataattatct taaaataatt taaacaatga
tttgcaatta 540gatgataata taaaattatt ttacacacta catgtattaa
actcaaactt ttatatatta 600gtttttctaa aaactaattt ttaactcaaa
aaaaatgtta cttataattt tcttatcttc 660tttttttata agtatttttt
aagaaattta ttgaaacatg accatgcttg ggtcaataat 720actactctct
tagacaccaa acaacccttc ccaaactata atctaatcca aaagccatca
780ttcattttcc ttggtaggta aagttccaag accttcacca actttttcac
tcaattgttt 840tggtgtaagc aattcgacat gtgttagtgt tagttggcaa
ccaaaaatcc ctttatgtga 900ctcaatccaa caaccactca caccaccaac
ccccataacc atttctcaca atacccttca 960tttacacatt atcatcacca
aaaataaata aaaaaaacct ctcatttcag agagagagag 1020agagacttca
cagaccaaag tgcagagaac aacaaagttc acaactttaa ggaaaattga
1080aatggcccaa gtgagcagag tgcacaatct tgctcaaagc actcaaattt
ttggccattc 1140ttccaactcc aacaaactca aatcggtgaa ttcggtttca
ttgaggccac gcctttgggg 1200ggcctcaaaa tctcgcatcc cgatgcataa
aaatggaagc tttatgggaa attttaatgt 1260ggggaaggga aattccggcg
tgtttaaggt ttctgcatcg gtcgccgccg cagagaagcc 1320gtcaacgtcg
ccggagatcg tgttggaacc catcaaagac ttctcgggta ccatcacatt
1380gccagggtcc aagtctctgt ccaatcgaat tttgcttctt gctgctctct
ctgaggttcg 1440tagatttctt ccgttttttt ttcttcttct ttattgtttg
ttctacatca gcatgatgtt 1500gatttgattg tgttttctat cgtttcatcg
attataaatt ttcataatca gaagattcag 1560cttttattaa tgcaagaacg
tccttaattg atgattttat aaccgtaaat taggtctaat 1620tagagttttt
ttcataaaga ttttcagatc cgtttacaac aagccttaat tgttgattct
1680gtagtcgtag attaaggttt ttttcatgaa ctacttcaga tccgttaaac
aacagcctta 1740tttgttgata cttcagtcgt ttttcaagaa attgttcaga
tccgttgata aaagccttat 1800tcgttgattc tgtatggtat ttcaagagat
attgctcagg tcctttagca actaccttat 1860ttgttgattc tgtggccata
gattaggatt ttttttcacg aaattgcttc ttgaaattac 1920gtgatggatt
ttgattctga tttatcttgt gattgttgac tctacaggga acaactgttg
1980tagacaactt gttgtatagt gaggatattc attacatgct tggtgcatta
aggacccttg 2040gactgcgtgt ggaagatgac aaaacaacca aacaagcaat
tgttgaaggc tgtgggggat 2100tgtttcccac tagtaaggaa tctaaagatg
aaatcaattt attccttgga aatgctggta 2160ttgcaatgag atctttgaca
gcagctgttg ttgctgcagg tggaaatgca aggtctgttt 2220tttttttttt
tgttcagcat aatctttgaa ttgttcctcg tataactaat cacaacagag
2280tacgtgttct tcttcctgtt ataatctaaa aatctcatcc agattagtca
tcctttcttc 2340ttaaaaggaa cctttaatta tcaatgtatt tatttaatat
ttaaattagc ttgtcaaagt 2400ctagcatata catattttga ttatattctg
agaaatgcac ctgagggtgt tcctcatgat 2460ctacttcaac ctctgttatt
attagatttt ctatcatgat tactggtttg agtctctaag 2520tagaccatct
tgatgttcaa aatatttcag ctacgtactt gatggggtgc cccgaatgag
2580agagaggcca attggggatt tggttgctgg tcttaagcaa cttggtgcag
atgttgattg 2640ctttcttggc acaaactgtc cacctgttcg tgtaaatggg
aagggaggac ttcctggcgg 2700aaaggtatgg tttggatttc atttagaata
aggtggagta actttcctgg atcaaaattc 2760taatttaaga agcctccctg
ttttcctctc tttagaataa gactaagggt aggtttagga 2820gttgggtttt
ggagagaaat ggaagggaga gcaatttttt tcttcttcta ataaatattc
2880tttaatttga tacatttttt aagtaaaaga atataaagat agattagcat
aacttaatgt 2940tttaatcttt tatttatttt tataaatatt atatacctgt
ctatttaaaa atcaaatatt 3000tgtcctccat tccctttccc ttcaaaacct
cagttccaaa tataccgtag ttgaattata 3060ttttggaagg cctattggtt
ggagactttt ccttttcaga gattatccct cacctttatt 3120atagcctttc
tatttttaaa cttcatatag acgccattct tggggcggcc gcgat
317549523DNAArtificial sequenceprimer, soy1-F3 495gtttgtttgt
tgttgggtgt ggg 2349625DNAArtificial sequenceprimer, soy1-R3
496gacatgatgc ttcattttca cagaa 2549718DNAArtificial sequencerobe,
soy1-T2(FAM-MGB) 497tgtgtagagt ggattttg 1849822DNAArtificial
sequenceprimer, soy1-F2 498tgttgttggg tgtgggaata gg
2249931DNAArtificial sequenceWOL1001, Forward_primer 499aggtttaatt
ttatataatg ttagcataca g 3150028DNAArtificial sequence500 WOL1002,
Reverse_primer 500atcaacatca tgctgatgta gaacaaac
2850129DNAArtificial sequence501 WOL1003, Forward_primer
501attctgattt atcttgtgat tgttgactc 2950227DNAArtificial
sequenceWOL1004, Reverse_primer 502atttactttg gagagaataa ggagggg
2750323DNAGlycine mac 503gaaacgttgg gacttagtag agg
2350423DNAGlycine max 504ggaataaaat aggaaacgtt ggg
235059174DNAArtificial sequenceRTW1201 505ccgggtgtga tttagtataa
agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta 60cctagtaata agtaatattg
aacaaaataa atggtaaagt gtcagatata taaaataggc 120tttaataaaa
ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt
180catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat
acattaaaaa 240atacttggat ctttctctta ccctgtttat attgagacct
gaaacttgag agagatacac 300taatcttgcc ttgttgtttc attccctaac
ttacaggact cagcgcatgt catgtggtct 360cgttccccat ttaagtccca
caccgtctaa acttattaaa ttattaatgt ttataactag 420atgcacaaca
acaaagcttg aaacgttggg acttagtagg ttttagagct agaaatagca
480agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc
ggtgcttttt 540tttgcggccg caattggatc gggtttactt attttgtggg
tatctatact tttattagat 600ttttaatcag gctcctgatt tctttttatt
tcgattgaat tcctgaactt gtattattca 660gtagatcgaa taaattataa
aaagataaaa tcataaaata atattttatc ctatcaatca 720tattaaagca
atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt
780tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt
attactttta 840aaaaaatcat aaaggtttag tattttttta aaataaatat
aggaatagtt ttactattca 900ctgctttaat agaaaaatag tttaaaattt
aagatagttt taatcccagc atttgccacg 960tttgaacgtg agccgaaacg
atgtcgttac attatcttaa cctagctgaa acgatgtcgt 1020cataatatcg
ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg
1080aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct
caatcccacg 1140cgagtagagc acagtaacct tcaaataagc gaatggggca
taatcagaaa tccgaaataa 1200acctaggggc attatcggaa atgaaaagta
gctcactcaa tataaaaatc taggaaccct 1260agttttcgtt atcactctgt
gctccctcgc tctatttctc agtctctgtg tttgcggctg 1320aggattccga
acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc
1380tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg
ttatgttttt 1440ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt
cgctttgttt ttgtggttca 1500gttttttagg attcttttgg tttttgaatc
gattaatcgg aagagatttt cgagttattt 1560ggtgtgttgg aggtgaatct
tttttttgag gtcatagatc tgttgtattt gtgttataaa 1620catgcgactt
tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc
1680tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag
gtttgtttta 1740acaggattaa aagtttttta agcatgttga aggagtcttg
tagatatgta accgtcgata 1800gtttttttgt gggtttgttc acatgttatc
aagcttaatc ttttactatg tatgcgacca 1860tatctggatc cagcaaaggc
gattttttaa ttccttgtga aacttttgta atatgaagtt 1920gaaattttgt
tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta
1980tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta
tttctttgaa 2040ttgattctag tttaagtaat ccatggcacc gaagaagaag
cgcaaggtga tggacaaaaa 2100gtactcaata gggctcgaca tagggactaa
ctccgttgga tgggccgtca tcaccgacga 2160gtacaaggtg ccctccaaga
agttcaaggt gttgggaaac accgacaggc acagcataaa 2220gaagaatttg
atcggtgccc tcctcttcga ctccggagag accgctgagg ctaccaggct
2280caagaggacc gctagaaggc gctacaccag aaggaagaac agaatctgct
acctgcagga 2340gatcttctcc aacgagatgg ccaaggtgga cgactccttc
ttccaccgcc ttgaggaatc 2400attcctggtg gaggaggata aaaagcacga
gagacaccca atcttcggga acatcgtcga 2460cgaggtggcc taccatgaaa
agtaccctac catctaccac ctgaggaaga agctggtcga 2520ctctaccgac
aaggctgact tgcgcttgat ttacctggct ctcgctcaca tgataaagtt
2580ccgcggacac ttcctcattg agggagacct gaacccagac aactccgacg
tggacaagct 2640cttcatccag ctcgttcaga cctacaacca gcttttcgag
gagaacccaa tcaacgccag 2700tggagttgac gccaaggcta tcctctctgc
tcgtctgtca aagtccagga ggcttgagaa 2760cttgattgcc cagctgcctg
gcgaaaagaa gaacggactg ttcggaaact tgatcgctct 2820ctccctggga
ttgactccca acttcaagtc caacttcgac ctcgccgagg acgctaagtt
2880gcagttgtct aaagacacct acgacgatga cctcgacaac ttgctggccc
agataggcga 2940ccaatacgcc gatctcttcc tcgccgctaa gaacttgtcc
gacgcaatcc tgctgtccga 3000catcctgaga gtcaacactg agattaccaa
agctcctctg tctgcttcca tgattaagcg 3060ctacgacgag caccaccaag
atctgaccct gctcaaggcc ctggtgagac agcagctgcc 3120cgagaagtac
aaggagatct ttttcgacca gtccaagaac ggctacgccg gatacattga
3180cggaggcgcc tcccaggaag agttctacaa gttcatcaag cccatccttg
agaagatgga 3240cggtaccgag gagctgttgg tgaagttgaa cagagaggac
ctgttgagga agcagagaac 3300cttcgacaac ggaagcatcc ctcaccaaat
ccacctggga gagctccacg ccatcttgag 3360gaggcaggag gatttctatc
ccttcctgaa ggacaaccgc gagaagattg agaagatctt 3420gaccttcaga
attccttact acgtcgggcc actcgccaga ggaaactcta ggttcgcctg
3480gatgacccgc aaatctgaag agaccattac tccctggaac ttcgaggaag
tcgtggacaa 3540gggcgcttcc gctcagtctt tcatcgagag gatgaccaac
ttcgataaaa atctgcccaa 3600cgagaaggtg ctgcccaagc actccctgtt
gtacgagtat ttcacagtgt acaacgagct 3660caccaaggtg aagtacgtca
cagagggaat gaggaagcct gccttcttgt ccggagagca 3720gaagaaggcc
atcgtcgacc tgctcttcaa gaccaacagg aaggtgactg tcaagcagct
3780gaaggaggac tacttcaaga agatcgagtg cttcgactcc gtcgagatct
ctggtgtcga 3840ggacaggttc aacgcctccc ttgggactta ccacgatctg
ctcaagatta ttaaagacaa 3900ggacttcctg gacaacgagg agaacgagga
catccttgag gacatcgtgc tcaccctgac 3960cttgttcgaa gacagggaaa
tgatcgaaga gaggctcaag acctacgccc acctcttcga 4020cgacaaggtg
atgaaacagc tgaagagacg cagatatacc ggctggggaa ggctctcccg
4080caaattgatc aacgggatca gggacaagca gtcagggaag actatactcg
acttcctgaa 4140gtccgacgga ttcgccaaca ggaacttcat gcagctcatt
cacgacgact ccttgacctt 4200caaggaggac atccagaagg ctcaggtgtc
tggacagggt gactccttgc atgagcacat 4260tgctaacttg gccggctctc
ccgctattaa gaagggcatt ttgcagaccg tgaaggtcgt 4320tgacgagctc
gtgaaggtga tgggacgcca caagccagag aacatcgtta ttgagatggc
4380tcgcgagaac caaactaccc agaaagggca gaagaattcc cgcgagagga
tgaagcgcat 4440tgaggagggc ataaaagagc ttggctctca gatcctcaag
gagcaccccg tcgagaacac 4500tcagctgcag aacgagaagc tgtacctgta
ctacctccaa aacggaaggg acatgtacgt 4560ggaccaggag ctggacatca
acaggttgtc cgactacgac gtcgaccaca tcgtgcctca 4620gtccttcctg
aaggatgact ccatcgacaa taaagtgctg acacgctccg ataaaaatag
4680aggcaagtcc gacaacgtcc cctccgagga ggtcgtgaag aagatgaaaa
actactggag 4740acagctcttg aacgccaagc tcatcaccca gcgtaagttc
gacaacctga ctaaggctga 4800gagaggagga ttgtccgagc tcgataaggc
cggattcatc aagagacagc tcgtcgaaac 4860ccgccaaatt accaagcacg
tggcccaaat tctggattcc cgcatgaaca ccaagtacga 4920tgaaaatgac
aagctgatcc gcgaggtcaa ggtgatcacc ttgaagtcca agctggtctc
4980cgacttccgc aaggacttcc agttctacaa ggtgagggag atcaacaact
accaccacgc 5040acacgacgcc tacctcaacg ctgtcgttgg aaccgccctc
atcaaaaaat atcctaagct 5100ggagtctgag ttcgtctacg gcgactacaa
ggtgtacgac gtgaggaaga tgatcgctaa 5160gtctgagcag gagatcggca
aggccaccgc caagtacttc ttctactcca acatcatgaa 5220cttcttcaag
accgagatca ctctcgccaa cggtgagatc aggaagcgcc cactgatcga
5280gaccaacggt gagactggag agatcgtgtg ggacaaaggg agggatttcg
ctactgtgag 5340gaaggtgctc tccatgcctc aggtgaacat cgtcaagaag
accgaagttc agaccggagg 5400attctccaag gagtccatcc tccccaagag
aaactccgac aagctgatcg ctagaaagaa 5460agactgggac cctaagaagt
acggaggctt cgattctcct accgtggcct actctgtgct 5520ggtcgtggcc
aaggtggaga agggcaagtc caagaagctg aaatccgtca aggagctcct
5580cgggattacc atcatggaga ggagttcctt cgagaagaac cctatcgact
tcctggaggc 5640caagggatat aaagaggtga agaaggacct catcatcaag
ctgcccaagt actccctctt 5700cgagttggag aacggaagga agaggatgct
ggcttctgcc ggagagttgc agaagggaaa 5760tgagctcgcc cttccctcca
agtacgtgaa cttcctgtac ctcgcctctc actatgaaaa 5820gttgaagggc
tctcctgagg acaacgagca gaagcagctc ttcgtggagc
agcacaagca 5880ctacctggac gaaattatcg agcagatctc tgagttctcc
aagcgcgtga tattggccga 5940cgccaacctc gacaaggtgc tgtccgccta
caacaagcac agggataagc ccattcgcga 6000gcaggctgaa aacattatcc
acctgtttac cctcacaaac ttgggagccc ctgctgcctt 6060caagtacttc
gacaccacca ttgacaggaa gagatacacc tccaccaagg aggtgctcga
6120cgcaacactc atccaccaat ccatcaccgg cctctatgaa acaaggattg
acttgtccca 6180gctgggaggc gactctagag ccgatcccaa gaagaagaga
aaggtgaaga gaccacggga 6240ccgccacgat ggcgagctgg gaggccgcaa
gcgggcaagg taggttaacc tagacttgtc 6300catcttctgg attggccaac
ttaattaatg tatgaaataa aaggatgcac acatagtgac 6360atgctaatca
ctataatgtg ggcatcaaag ttgtgtgtta tgtgtaatta ctagttatct
6420gaataaaaga gaaagagatc atccatattt cttatcctaa atgaatgtca
cgtgtcttta 6480taattctttg atgaaccaga tgcatttcat taaccaaatc
catatacata taaatattaa 6540tcatatataa ttaatatcaa ttgggttagc
aaaacaaatc tagtctaggt gtgttttgcg 6600aattcgatat caagcttatc
gataccgtcg agggggggcc cggtaccggc gcgccgttct 6660atagtgtcac
ctaaatcgta tgtgtatgat acataaggtt atgtattaat tgtagccgcg
6720ttctaacgac aatatgtcca tatggtgcac tctcagtaca atctgctctg
atgccgcata 6780gttaagccag ccccgacacc cgccaacacc cgctgacgcg
ccctgacggg cttgtctgct 6840cccggcatcc gcttacagac aagctgtgac
cgtctccggg agctgcatgt gtcagaggtt 6900ttcaccgtca tcaccgaaac
gcgcgagacg aaagggcctc gtgatacgcc tatttttata 6960ggttaatgtc
atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc
7020cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa
tctgctgctt 7080gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg
ccggatcaag agctaccaac 7140tctttttccg aaggtaactg gcttcagcag
agcgcagata ccaaatactg ttcttctagt 7200gtagccgtag ttaggccacc
acttcaagaa ctctgtagca ccgcctacat acctcgctct 7260gctaatcctg
ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga
7320ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg
gttcgtgcac 7380acagcccagc ttggagcgaa cgacctacac cgaactgaga
tacctacagc gtgagctatg 7440agaaagcgcc acgcttcccg aagggagaaa
ggcggacagg tatccggtaa gcggcagggt 7500cggaacagga gagcgcacga
gggagcttcc agggggaaac gcctggtatc tttatagtcc 7560tgtcgggttt
cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg
7620gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct
tttgctggcc 7680ttttgctcac atgttctttc ctgcgttatc ccctgattct
gtggataacc gtattaccgc 7740ctttgagtga gctgataccg ctcgccgcag
ccgaacgacc gagcgcagcg agtcagtgag 7800cgaggaagcg gaagagcgcc
caatacgcaa accgcctctc cccgcgcgtt ggccgattca 7860ttaatgcagg
ttgatcagat ctcgatcccg cgaaattaat acgactcact atagggagac
7920cacaacggtt tccctctaga aataattttg tttaacttta agaaggagat
atacccatgg 7980aaaagcctga actcaccgcg acgtctgtcg agaagtttct
gatcgaaaag ttcgacagcg 8040tctccgacct gatgcagctc tcggagggcg
aagaatctcg tgctttcagc ttcgatgtag 8100gagggcgtgg atatgtcctg
cgggtaaata gctgcgccga tggtttctac aaagatcgtt 8160atgtttatcg
gcactttgca tcggccgcgc tcccgattcc ggaagtgctt gacattgggg
8220aattcagcga gagcctgacc tattgcatct cccgccgtgc acagggtgtc
acgttgcaag 8280acctgcctga aaccgaactg cccgctgttc tgcagccggt
cgcggaggct atggatgcga 8340tcgctgcggc cgatcttagc cagacgagcg
ggttcggccc attcggaccg caaggaatcg 8400gtcaatacac tacatggcgt
gatttcatat gcgcgattgc tgatccccat gtgtatcact 8460ggcaaactgt
gatggacgac accgtcagtg cgtccgtcgc gcaggctctc gatgagctga
8520tgctttgggc cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat
ttcggctcca 8580acaatgtcct gacggacaat ggccgcataa cagcggtcat
tgactggagc gaggcgatgt 8640tcggggattc ccaatacgag gtcgccaaca
tcttcttctg gaggccgtgg ttggcttgta 8700tggagcagca gacgcgctac
ttcgagcgga ggcatccgga gcttgcagga tcgccgcggc 8760tccgggcgta
tatgctccgc attggtcttg accaactcta tcagagcttg gttgacggca
8820atttcgatga tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga
tccggagccg 8880ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc
cgtctggacc gatggctgtg 8940tagaagtact cgccgatagt ggaaaccgac
gccccagcac tcgtccgagg gcaaaggaat 9000agtgaggtac agcttggatc
gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg 9060ctgctgccac
cgctgagcaa taactagcat aaccccttgg ggcctctaaa cgggtcttga
9120ggggtttttt gctgaaagga ggaactatat ccggatgctc gggcgcgccg gtac
91745069174DNAArtificial sequenceRTW1202 506ccgggtgtga tttagtataa
agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta 60cctagtaata agtaatattg
aacaaaataa atggtaaagt gtcagatata taaaataggc 120tttaataaaa
ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt
180catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat
acattaaaaa 240atacttggat ctttctctta ccctgtttat attgagacct
gaaacttgag agagatacac 300taatcttgcc ttgttgtttc attccctaac
ttacaggact cagcgcatgt catgtggtct 360cgttccccat ttaagtccca
caccgtctaa acttattaaa ttattaatgt ttataactag 420atgcacaaca
acaaagcttg gaataaaata ggaaacgttg ttttagagct agaaatagca
480agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc
ggtgcttttt 540tttgcggccg caattggatc gggtttactt attttgtggg
tatctatact tttattagat 600ttttaatcag gctcctgatt tctttttatt
tcgattgaat tcctgaactt gtattattca 660gtagatcgaa taaattataa
aaagataaaa tcataaaata atattttatc ctatcaatca 720tattaaagca
atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt
780tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt
attactttta 840aaaaaatcat aaaggtttag tattttttta aaataaatat
aggaatagtt ttactattca 900ctgctttaat agaaaaatag tttaaaattt
aagatagttt taatcccagc atttgccacg 960tttgaacgtg agccgaaacg
atgtcgttac attatcttaa cctagctgaa acgatgtcgt 1020cataatatcg
ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg
1080aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct
caatcccacg 1140cgagtagagc acagtaacct tcaaataagc gaatggggca
taatcagaaa tccgaaataa 1200acctaggggc attatcggaa atgaaaagta
gctcactcaa tataaaaatc taggaaccct 1260agttttcgtt atcactctgt
gctccctcgc tctatttctc agtctctgtg tttgcggctg 1320aggattccga
acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc
1380tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg
ttatgttttt 1440ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt
cgctttgttt ttgtggttca 1500gttttttagg attcttttgg tttttgaatc
gattaatcgg aagagatttt cgagttattt 1560ggtgtgttgg aggtgaatct
tttttttgag gtcatagatc tgttgtattt gtgttataaa 1620catgcgactt
tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc
1680tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag
gtttgtttta 1740acaggattaa aagtttttta agcatgttga aggagtcttg
tagatatgta accgtcgata 1800gtttttttgt gggtttgttc acatgttatc
aagcttaatc ttttactatg tatgcgacca 1860tatctggatc cagcaaaggc
gattttttaa ttccttgtga aacttttgta atatgaagtt 1920gaaattttgt
tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta
1980tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta
tttctttgaa 2040ttgattctag tttaagtaat ccatggcacc gaagaagaag
cgcaaggtga tggacaaaaa 2100gtactcaata gggctcgaca tagggactaa
ctccgttgga tgggccgtca tcaccgacga 2160gtacaaggtg ccctccaaga
agttcaaggt gttgggaaac accgacaggc acagcataaa 2220gaagaatttg
atcggtgccc tcctcttcga ctccggagag accgctgagg ctaccaggct
2280caagaggacc gctagaaggc gctacaccag aaggaagaac agaatctgct
acctgcagga 2340gatcttctcc aacgagatgg ccaaggtgga cgactccttc
ttccaccgcc ttgaggaatc 2400attcctggtg gaggaggata aaaagcacga
gagacaccca atcttcggga acatcgtcga 2460cgaggtggcc taccatgaaa
agtaccctac catctaccac ctgaggaaga agctggtcga 2520ctctaccgac
aaggctgact tgcgcttgat ttacctggct ctcgctcaca tgataaagtt
2580ccgcggacac ttcctcattg agggagacct gaacccagac aactccgacg
tggacaagct 2640cttcatccag ctcgttcaga cctacaacca gcttttcgag
gagaacccaa tcaacgccag 2700tggagttgac gccaaggcta tcctctctgc
tcgtctgtca aagtccagga ggcttgagaa 2760cttgattgcc cagctgcctg
gcgaaaagaa gaacggactg ttcggaaact tgatcgctct 2820ctccctggga
ttgactccca acttcaagtc caacttcgac ctcgccgagg acgctaagtt
2880gcagttgtct aaagacacct acgacgatga cctcgacaac ttgctggccc
agataggcga 2940ccaatacgcc gatctcttcc tcgccgctaa gaacttgtcc
gacgcaatcc tgctgtccga 3000catcctgaga gtcaacactg agattaccaa
agctcctctg tctgcttcca tgattaagcg 3060ctacgacgag caccaccaag
atctgaccct gctcaaggcc ctggtgagac agcagctgcc 3120cgagaagtac
aaggagatct ttttcgacca gtccaagaac ggctacgccg gatacattga
3180cggaggcgcc tcccaggaag agttctacaa gttcatcaag cccatccttg
agaagatgga 3240cggtaccgag gagctgttgg tgaagttgaa cagagaggac
ctgttgagga agcagagaac 3300cttcgacaac ggaagcatcc ctcaccaaat
ccacctggga gagctccacg ccatcttgag 3360gaggcaggag gatttctatc
ccttcctgaa ggacaaccgc gagaagattg agaagatctt 3420gaccttcaga
attccttact acgtcgggcc actcgccaga ggaaactcta ggttcgcctg
3480gatgacccgc aaatctgaag agaccattac tccctggaac ttcgaggaag
tcgtggacaa 3540gggcgcttcc gctcagtctt tcatcgagag gatgaccaac
ttcgataaaa atctgcccaa 3600cgagaaggtg ctgcccaagc actccctgtt
gtacgagtat ttcacagtgt acaacgagct 3660caccaaggtg aagtacgtca
cagagggaat gaggaagcct gccttcttgt ccggagagca 3720gaagaaggcc
atcgtcgacc tgctcttcaa gaccaacagg aaggtgactg tcaagcagct
3780gaaggaggac tacttcaaga agatcgagtg cttcgactcc gtcgagatct
ctggtgtcga 3840ggacaggttc aacgcctccc ttgggactta ccacgatctg
ctcaagatta ttaaagacaa 3900ggacttcctg gacaacgagg agaacgagga
catccttgag gacatcgtgc tcaccctgac 3960cttgttcgaa gacagggaaa
tgatcgaaga gaggctcaag acctacgccc acctcttcga 4020cgacaaggtg
atgaaacagc tgaagagacg cagatatacc ggctggggaa ggctctcccg
4080caaattgatc aacgggatca gggacaagca gtcagggaag actatactcg
acttcctgaa 4140gtccgacgga ttcgccaaca ggaacttcat gcagctcatt
cacgacgact ccttgacctt 4200caaggaggac atccagaagg ctcaggtgtc
tggacagggt gactccttgc atgagcacat 4260tgctaacttg gccggctctc
ccgctattaa gaagggcatt ttgcagaccg tgaaggtcgt 4320tgacgagctc
gtgaaggtga tgggacgcca caagccagag aacatcgtta ttgagatggc
4380tcgcgagaac caaactaccc agaaagggca gaagaattcc cgcgagagga
tgaagcgcat 4440tgaggagggc ataaaagagc ttggctctca gatcctcaag
gagcaccccg tcgagaacac 4500tcagctgcag aacgagaagc tgtacctgta
ctacctccaa aacggaaggg acatgtacgt 4560ggaccaggag ctggacatca
acaggttgtc cgactacgac gtcgaccaca tcgtgcctca 4620gtccttcctg
aaggatgact ccatcgacaa taaagtgctg acacgctccg ataaaaatag
4680aggcaagtcc gacaacgtcc cctccgagga ggtcgtgaag aagatgaaaa
actactggag 4740acagctcttg aacgccaagc tcatcaccca gcgtaagttc
gacaacctga ctaaggctga 4800gagaggagga ttgtccgagc tcgataaggc
cggattcatc aagagacagc tcgtcgaaac 4860ccgccaaatt accaagcacg
tggcccaaat tctggattcc cgcatgaaca ccaagtacga 4920tgaaaatgac
aagctgatcc gcgaggtcaa ggtgatcacc ttgaagtcca agctggtctc
4980cgacttccgc aaggacttcc agttctacaa ggtgagggag atcaacaact
accaccacgc 5040acacgacgcc tacctcaacg ctgtcgttgg aaccgccctc
atcaaaaaat atcctaagct 5100ggagtctgag ttcgtctacg gcgactacaa
ggtgtacgac gtgaggaaga tgatcgctaa 5160gtctgagcag gagatcggca
aggccaccgc caagtacttc ttctactcca acatcatgaa 5220cttcttcaag
accgagatca ctctcgccaa cggtgagatc aggaagcgcc cactgatcga
5280gaccaacggt gagactggag agatcgtgtg ggacaaaggg agggatttcg
ctactgtgag 5340gaaggtgctc tccatgcctc aggtgaacat cgtcaagaag
accgaagttc agaccggagg 5400attctccaag gagtccatcc tccccaagag
aaactccgac aagctgatcg ctagaaagaa 5460agactgggac cctaagaagt
acggaggctt cgattctcct accgtggcct actctgtgct 5520ggtcgtggcc
aaggtggaga agggcaagtc caagaagctg aaatccgtca aggagctcct
5580cgggattacc atcatggaga ggagttcctt cgagaagaac cctatcgact
tcctggaggc 5640caagggatat aaagaggtga agaaggacct catcatcaag
ctgcccaagt actccctctt 5700cgagttggag aacggaagga agaggatgct
ggcttctgcc ggagagttgc agaagggaaa 5760tgagctcgcc cttccctcca
agtacgtgaa cttcctgtac ctcgcctctc actatgaaaa 5820gttgaagggc
tctcctgagg acaacgagca gaagcagctc ttcgtggagc agcacaagca
5880ctacctggac gaaattatcg agcagatctc tgagttctcc aagcgcgtga
tattggccga 5940cgccaacctc gacaaggtgc tgtccgccta caacaagcac
agggataagc ccattcgcga 6000gcaggctgaa aacattatcc acctgtttac
cctcacaaac ttgggagccc ctgctgcctt 6060caagtacttc gacaccacca
ttgacaggaa gagatacacc tccaccaagg aggtgctcga 6120cgcaacactc
atccaccaat ccatcaccgg cctctatgaa acaaggattg acttgtccca
6180gctgggaggc gactctagag ccgatcccaa gaagaagaga aaggtgaaga
gaccacggga 6240ccgccacgat ggcgagctgg gaggccgcaa gcgggcaagg
taggttaacc tagacttgtc 6300catcttctgg attggccaac ttaattaatg
tatgaaataa aaggatgcac acatagtgac 6360atgctaatca ctataatgtg
ggcatcaaag ttgtgtgtta tgtgtaatta ctagttatct 6420gaataaaaga
gaaagagatc atccatattt cttatcctaa atgaatgtca cgtgtcttta
6480taattctttg atgaaccaga tgcatttcat taaccaaatc catatacata
taaatattaa 6540tcatatataa ttaatatcaa ttgggttagc aaaacaaatc
tagtctaggt gtgttttgcg 6600aattcgatat caagcttatc gataccgtcg
agggggggcc cggtaccggc gcgccgttct 6660atagtgtcac ctaaatcgta
tgtgtatgat acataaggtt atgtattaat tgtagccgcg 6720ttctaacgac
aatatgtcca tatggtgcac tctcagtaca atctgctctg atgccgcata
6780gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg
cttgtctgct 6840cccggcatcc gcttacagac aagctgtgac cgtctccggg
agctgcatgt gtcagaggtt 6900ttcaccgtca tcaccgaaac gcgcgagacg
aaagggcctc gtgatacgcc tatttttata 6960ggttaatgtc atgaccaaaa
tcccttaacg tgagttttcg ttccactgag cgtcagaccc 7020cgtagaaaag
atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt
7080gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag
agctaccaac 7140tctttttccg aaggtaactg gcttcagcag agcgcagata
ccaaatactg ttcttctagt 7200gtagccgtag ttaggccacc acttcaagaa
ctctgtagca ccgcctacat acctcgctct 7260gctaatcctg ttaccagtgg
ctgctgccag tggcgataag tcgtgtctta ccgggttgga 7320ctcaagacga
tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac
7380acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc
gtgagctatg 7440agaaagcgcc acgcttcccg aagggagaaa ggcggacagg
tatccggtaa gcggcagggt 7500cggaacagga gagcgcacga gggagcttcc
agggggaaac gcctggtatc tttatagtcc 7560tgtcgggttt cgccacctct
gacttgagcg tcgatttttg tgatgctcgt caggggggcg 7620gagcctatgg
aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc
7680ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc
gtattaccgc 7740ctttgagtga gctgataccg ctcgccgcag ccgaacgacc
gagcgcagcg agtcagtgag 7800cgaggaagcg gaagagcgcc caatacgcaa
accgcctctc cccgcgcgtt ggccgattca 7860ttaatgcagg ttgatcagat
ctcgatcccg cgaaattaat acgactcact atagggagac 7920cacaacggtt
tccctctaga aataattttg tttaacttta agaaggagat atacccatgg
7980aaaagcctga actcaccgcg acgtctgtcg agaagtttct gatcgaaaag
ttcgacagcg 8040tctccgacct gatgcagctc tcggagggcg aagaatctcg
tgctttcagc ttcgatgtag 8100gagggcgtgg atatgtcctg cgggtaaata
gctgcgccga tggtttctac aaagatcgtt 8160atgtttatcg gcactttgca
tcggccgcgc tcccgattcc ggaagtgctt gacattgggg 8220aattcagcga
gagcctgacc tattgcatct cccgccgtgc acagggtgtc acgttgcaag
8280acctgcctga aaccgaactg cccgctgttc tgcagccggt cgcggaggct
atggatgcga 8340tcgctgcggc cgatcttagc cagacgagcg ggttcggccc
attcggaccg caaggaatcg 8400gtcaatacac tacatggcgt gatttcatat
gcgcgattgc tgatccccat gtgtatcact 8460ggcaaactgt gatggacgac
accgtcagtg cgtccgtcgc gcaggctctc gatgagctga 8520tgctttgggc
cgaggactgc cccgaagtcc ggcacctcgt gcacgcggat ttcggctcca
8580acaatgtcct gacggacaat ggccgcataa cagcggtcat tgactggagc
gaggcgatgt 8640tcggggattc ccaatacgag gtcgccaaca tcttcttctg
gaggccgtgg ttggcttgta 8700tggagcagca gacgcgctac ttcgagcgga
ggcatccgga gcttgcagga tcgccgcggc 8760tccgggcgta tatgctccgc
attggtcttg accaactcta tcagagcttg gttgacggca 8820atttcgatga
tgcagcttgg gcgcagggtc gatgcgacgc aatcgtccga tccggagccg
8880ggactgtcgg gcgtacacaa atcgcccgca gaagcgcggc cgtctggacc
gatggctgtg 8940tagaagtact cgccgatagt ggaaaccgac gccccagcac
tcgtccgagg gcaaaggaat 9000agtgaggtac agcttggatc gatccggctg
ctaacaaagc ccgaaaggaa gctgagttgg 9060ctgctgccac cgctgagcaa
taactagcat aaccccttgg ggcctctaaa cgggtcttga 9120ggggtttttt
gctgaaagga ggaactatat ccggatgctc gggcgcgccg gtac
91745076113DNAArtificial sequenceRTW1192A 507caagtagttc tagtcttaat
acaaatgtca aatggcacaa gtgagatttt gaatttctga 60tgttgtaaaa atctcaggac
atgaatacta ttgggaagca attattcata cttcaccaat 120ccaaactgac
ccaaaattct caaatcacat gaaagcaaaa atgcatataa cacgaagaat
180aagaagaaga ggaactaacc tggggtttcg atgattaaag cgttgttgtt
gatgatgaaa 240acgatgatta tggagagaaa ttgttgttga atggtgaaat
tgttatagaa agagaacgaa 300gatagagaaa aagatatata gatttttcaa
ggctcaaacc ctaaaatcac catgagagag 360aacaaagatt gagaaaccta
caaccactat gagagagaat gagcagaaca gaagcgtgag 420atagagaacg
agagttaagg tgcgagagga cacgaagaac aaaaggtgtg agagaaagaa
480caaaggagcc tacggtgtga gatgagagaa tttgaaattc ttaccattta
ggtggaattt 540caattctaca attttattct attaaaatta ttttaaaaaa
tgatgtcatt ttaaattctt 600taaaatctca tatccaacaa ctgaattatg
atagaggtat ttcaaattca cttaaaaaaa 660ttatcttatt taaatacccc
atccaaacat agcgaaatgt tcatgagaag gatcaagtgg 720tttggaaaca
tagtactaat ggtgtttata cagttcatgg aatccttgat agataattta
780aaggttgctg gaaattggat gaaggtgtgg agattaaata ttcttccaaa
aataaagcgt 840tttatttgga gagtgttgtg tggttgtctc ccctgtaggc
aaaagcttcg atgtaaagga 900gttcaatgtc caataaccta tgctttctat
ccctcgatta ttgaaaatga atgacacatt 960ttatttggtt gaaatcaaga
aataagcatg tggcaagcaa cgggtatttg acaattcata 1020gaacaaaagg
tgaatgcagc aaaagaatta atgaactcct tttcgatcta cttggatcac
1080tacatggaga tattatcaac aaatttgatg ttactttatg gagcagttgg
aattcttgga 1140atgacaagat atgaaatgaa cataccaacc ctcctcttgt
ttctgtttcg gtttctatgc 1200agtattttgt tgaatggcaa agtgcaaggt
aatatgctcc tcaacatcaa ttaacaaatg 1260ttcatgacat ctcttaccag
ctccaacttg gggacgtttg acaaacacca ccgtcaagtt 1320tccttaaatg
caacattaat gttgctcatt tcaaggagga gaatagtttt ggtgtcggca
1380tgatactcca tcaaggaaga ttcgtcaaag ctcactcacg ttttcgacat
gggtcgacat 1440gggttacctg acccaaaggc tgaggcttag gcttgggttt
gcttcaagta ttgatctggg 1500cccagactat tggtttacat aatatcattt
ttgaaaacct aacatctaaa actcaaggtt 1560gtttagaggt gcgccattcc
aaaataagat tatcctattt gtgcatgaat gcgaccaact 1620atctcctgtt
tcagcattat aaagtataaa caacaaactt ctttaatcaa gggactaaaa
1680gatattggac atacaagcta aaagtgatag aatttgagaa aacaaatatt
gacaacaata 1740ttcaagagga cactaaaaca taattctcaa attttttttg
tttatttaaa ataaagtggt 1800tcattaggta gctccgggtg attgcggtta
catcatgtac ggaaaaataa ttctaatcct 1860tgatttaaat ttgaacttga
ctatttattt attctttatt tcattttgta aatcatttta 1920tgtatctcct
ggcaagcaat tttatccacc ttgcaccaac accttcgggt tccataatca
1980aaccacctta acttcacacc atgctgtaac tcacaccgcc cagcatctcc
aatgtgaaag 2040aagctaaaat ttaataaaca atcatacgaa gcagtgacaa
aataccagat ggtattaatg 2100cttcgataaa attaattgga aagtataaaa
tggtagaaaa taataaatta taattaattt 2160aagtaagata aaaaataatt
aaaaactaaa atgttaaaat tttaaaaaaa ttattttaaa 2220taatatttaa
aaacattaaa aatcatttta aaaaatttat ttatagaaca attaaataaa
2280tatttcagct aataaaaaac aaaagcttac ctagccttag aagacaactt
gtccaacaat 2340tagatgatac ccattgccct tacgttttct ttaacatcaa
ttattgtttt tgtcaacaag 2400ctatctttta gttttatttt attggtaaaa
aatatgtcgc cttcaagttg catcatttaa 2460cacatctcgt cattagaaaa
ataaaactct tccctaaacg attagtagaa aaaatcattc 2520gataataaat
aagaaagaaa aattagaaaa aaataacttc attttaaaaa aatcattaag
2580gctatatttt ttaaatgact aattttatat agactgtaac taaaagtata
caatttatta 2640tgctatgtat cttaaagaat tacttataaa aatctacgga
agaatatctt acaaagtgaa 2700aaacaaatga gaaagaattt agtgggatga
ttatgatttt atttgaaaat tgaaaaaata 2760attattaaag actttagtgg
agtaagaaag ctttcctatt agtcttttct tatccataaa 2820aaaaaaaaaa
aaaatctagc gtgacagctt ttccatagat tttaataatg taaaatactg
2880gtagcagccg accgttcagg taatggacac tgtggtccta acttgcaacg
ggtgcgggcc 2940caatttaata acgccgtggt aacggataaa gccaagcgtg
aagcggtgaa ggtacatctc 3000tgactccgtc aagattacga aaccgtcaac
tacgaaggac tccccgaaat atcatctgtg 3060tcataaacac caagtcacac
catacatggg cacgcgtcac aatatgattg gagaacggtt 3120ccaccgcata
tgctataaaa tgcccccaca cccctcgacc ctaatcgcac ttcaattgca
3180atcaaattag ttcattctct ttgcgcagtt ccctacctct cctttcaagg
ttcgtagatt 3240tcttccgttt ttttttcttc ttctttattg tttgttctac
atcagcatga tgttgatttg 3300attgtgtttt ctatcgtttc atcgattata
aattttcata atcagaagat tcagctttta 3360ttaatgcaag aacgtcctta
attgatgatt ttataaccgt aaattaggtc taattagagt 3420ttttttcata
aagattttca gatccgttta caacaagcct taattgttga ttctgtagtc
3480gtagattaag gtttttttca tgaactactt cagatccgtt aaacaacagc
cttatttgtt 3540gatacttcag tcgtttttca agaaattgtt cagatccgtt
gataaaagcc ttattcgttg 3600attctgtatg gtatttcaag agatattgct
caggtccttt agcaactacc ttatttgttg 3660attctgtggc catagattag
gatttttttt cacgaaattg cttcttgaaa ttacgtgatg 3720gattttgatt
ctgatttatc ttgtgattgt tgactctaca gatggcccaa gtgagcagag
3780tgcacaatct tgctcaaagc actcaaattt ttggccattc ttccaactcc
aacaaactca 3840aatcggtgaa ttcggtttca ttgaggccac gcctttgggg
ggcctcaaaa tctcgcatcc 3900cgatgcataa aaatggaagc tttatgggaa
attttaatgt ggggaaggga aattccggcg 3960tgtttaaggt ttctgcatcg
gtcgccgccg cagagaagcc gtcaacgtcg ccggagatcg 4020tgttggaacc
catcaaagac ttctcgggta ccatcacatt gccagggtcc aagtctctgt
4080ccaatcgaat tttgcttctt gctgctctct ctgaggtgaa gtttatttat
ttatttattt 4140gtttgtttgt tgttgggtgt gggaatagga gtttgatgtg
tagagtggat tttgaatatt 4200tgattttttt ttgtattatt ctgtgaaaat
gaagcatcat gtcccatgaa agaaatggac 4260acgaaattaa gtggcttatg
atgtgaaatg aggatagaaa tgtgtgtagg gttttttaat 4320gggtagcaat
aagcatattc aatatctgga ttgatttgga cgtttctgta taaaggagta
4380tgctagcaat gtgttaatgt atggcttgct aaaatactcc taaaaatcaa
gtgggagtag 4440tatacatatc tacagcaaat gtattaggtg aggcatttgg
cttctctatt gtaaggaaca 4500aataatatca gttaatgtga aaatcaatgg
ttgatattcc aatacattca tgatgtgtta 4560tttatatgta cctaatattg
actgttgttt ttctccgcaa tgaccaagat tatttatttt 4620atcctctaaa
gtgactaatt gagttgctta ctttagagaa gttggaccca ttaggtgaga
4680gcgtgggggg aactaatctt gaatatacaa tctgagtctt gattatccaa
gtatggttgt 4740atgaacaatg ttagctctag aagataaacc ctcccccaaa
acacaaatta gaatgacatt 4800tcaagttcca tgtatgtcac tttcattcta
ttatttttac aacttttagt tacttaacag 4860atgtcttgtt cagcataaat
tataatttat tctgtttttt tttagggaac aactgttgta 4920gacaacttgt
tgtatagtga ggatattcat tacatgcttg gtgcattaag gacccttgga
4980ctgcgtgtgg aagatgacaa aacaaccaaa caagcaattg ttgaaggctg
tgggggattg 5040tttcccacta gtaaggaatc taaagatgaa atcaatttat
tccttggaaa tgctggtatt 5100gcaatgagat ctttgacagc agctgttgtt
gctgcaggtg gaaatgcaag gtctgttttt 5160tttttttttg ttcagcataa
tctttgaatt gttcctcgta taactaatca caacagagta 5220cgtgttcttc
ttcctgttat aatctaaaaa tctcatccag attagtcatc ctttcttctt
5280aaaaggaacc tttaattatc aatgtattta tttaatattt aaattagctt
gtcaaagtct 5340agcatataca tattttgatt atattctgag aaatgcacct
gagggtgttc ctcatgatct 5400acttcaacct ctgttattat tagattttct
atcatgatta ctggtttgag tctctaagta 5460gaccatcttg atgttcaaaa
tatttcagct acgtacttga tggggtgccc cgaatgagag 5520agaggccaat
tggggatttg gttgctggtc ttaagcaact tggtgcagat gttgattgct
5580ttcttggcac aaactgtcca cctgttcgtg taaatgggaa gggaggactt
cctggcggaa 5640aggtatggtt tggatttcat ttagaataag gtggagtaac
tttcctggat caaaattcta 5700atttaagaag cctccctgtt ttcctctctt
tagaataaga ctaagggtag gtttaggagt 5760tgggttttgg agagaaatgg
aagggagagc aatttttttc ttcttctaat aaatattctt 5820taatttgata
cattttttaa gtaaaagaat ataaagatag attagcataa cttaatgttt
5880taatctttta tttattttta taaatattat atacctgtct atttaaaaat
caaatatttg 5940tcctccattc cctttccctt caaaacctca gttccaaata
taccgtagtt gaattatatt 6000ttggaaggcc tattggttgg agacttttcc
ttttcagaga ttatccctca cctttattat 6060agcctttcta tttttaaact
tcatatagac gccattcttg gggcggccgc gat 611350832DNAArtificial
sequenceprimer, soy1-F4 508tcaataatac tactctctta gacaccaaac aa
3250923DNAArtificial sequenceprimer, soy1-R4 509caaggaaaat
gaatgatggc ttt 2351018DNAArtificial sequenceprobe, soy1-T3(FAM-MGB)
510ccttcccaaa ctataatc 1851127DNAArtificial sequenceWOL1005,
Forward_primer 511aaatgttatc agaggaacat gagctgc
2751228DNAArtificial sequenceWOL1006, Reverse_primer 512attatttttc
cgtacatgat gtaaccgc 28513438DNACauliflower mozaic virus
513cccatggagt caaagattca aatagaggac ctaacagaac tcgccgtaaa
gactggcgaa 60cagttcatac agagtctctt acgactcaat gacaagaaga aaatcttcgt
caacatggtg 120gagcacgaca cgcttgtcta ctccaaaaat atcaaagata
cagtctcaga agaccaaagg 180gcaattgaga cttttcaaca aagggtaata
tccggaaacc tcctcggatt ccattgccca 240gctatctgtc actttattgt
gaagatagtg gaaaaggaag gtggctccta caaatgccat 300cattgcgata
aaggaaaggc catcgttgaa gatgcctctg ccgacagtgg tcccaaagat
360ggacccccac ccacgaggag catcgtggaa aaagaagacg ttccaaccac
gtcttcaaag 420caagtggatt gatgtgat 43851419DNACauliflower mozaic
virus 514gtctcagaag accaaaggg 1951525DNACauliflower mozaic virus
515tgccatcatt gcgataaagg aaagg 2551620DNACauliflower mozaic virus
516gatgcctctg ccgacagtgg 205173708DNAZea mays 517ctgcagccca
tcaaggagat ctccggcacc gtcaagctgc cggggtccaa gtcgctttcc 60aacaggatcc
tcctgctcgc cgccctgtcc gaggtgagcg attttggtgc ttgctgcgct
120gccctgtctc actgctacct aaatgttttg cctgtcgaat accatggatt
ctcggtgtaa 180tccatctcac gatcagatgc accgcatgtc gcatgcctag
ctctctctaa tttgtctagt 240agtttgtata cggattaaga ttgataaatc
ggtaccgcaa aagctaggtg taaataaaca 300ctacaaaatt ggatgttccc
ctatcggcct gtactcggct actcgttctt gtgatggcat 360gttatttctt
cttggtgttt ggtgaactcc cttatgaaat ttgggcgcaa agaaatcgcc
420ctcaagggtt gatcttatgc catcgtcatg ataaacagtg aagcacggat
gatcctttac 480gttgttttta acaaactttg tcagaaaact agcaatgtta
acttcttaat gatgatttca 540caacaaaaaa ggtaaccttg ctactaacat
aacaaaagac ttgttgctta ttaattatat 600gtttttttaa tctttgatca
ggggacaaca gtggttgata acctgttgaa cagtgaggat 660gtccactaca
tgctcggggc cttgaggact cttggtctct ctgtcgaagc ggacaaagct
720gccaaaagag ctgtagttgt tggctgtggt ggaaagttcc cagttgagga
tgctagagag 780gaagtgcagc tcttcttggg gaatgctgga atcgcaatgc
ggtcattgac agcagctgtt 840actgctgctg gtggaaatgc aacgtatgtt
tcctctctct ctctacaata cttgttggag 900ttagtatgaa acccatgtgt
atgtctagtg gcttatggtg tattggtttt tgaacttcag 960ttacgtgctt
gatggagtac caagaatgag ggagagaccc attggcgact tggttgtcgg
1020attgaagcag cttggtgcag atgttgattg tttccttggc actgactgcc
cacctgttcg 1080tgtcaatgga atcggagggc tacctggtgg caaggttagt
tactaagggc cacatgttac 1140attcttctgt aaatggtaca actattgtcg
agcttttgca tttgtaagga aaacattgat 1200tgatctgaat ttgatgctac
accacaaaat atctacaaat ggtcatccct aactagcaaa 1260ccatgtctcc
attaagctca atgaagtaat acttggcatg tgtttatcaa cttaatttcc
1320atcttctggg gtattgcctg ttttctagtc taatagcatt tgtttttaga
attagctctt 1380acaactgtta tgttctacag gtcaagctgt ctggctccat
cagcagtcag tacttgagtg 1440ccttgctgat ggctgctcct ttggctcttg
gggatgtgga gattgaaatc attgataaat 1500taatctccat tccctacgtc
gaaatgacat tgagattgat ggagcgtttt ggtgtgaaag 1560cagagcattc
tgatagctgg gacagattct acattaaggg aggtcaaaaa tacaagtaag
1620ctctgtaatg tatttcacta ctttgatgcc aatgtttcag ttttcagttt
tccaaacagt 1680cgcatcaata tttgaataga tgcactgtag aaaaaaatca
ttgcagggaa aaactagtac 1740tgagtatttt gactgtaaat tatttaacca
gtcggaatat agtcagtcta ttggagtcaa 1800gagcgtgaac cgaaatagcc
agttaattat cccattatac agaggacaac catgtatact 1860attgaaactt
ggtttaagag aatctaggta gctggactcg tagctgcttg gcatggatac
1920cttcttatct ttaggaaaag acacttgatt ttttttctgt ggccctctat
gatgtgtgaa 1980cctgcttctc tattgcttta gaaggatata tctatgtcgt
tatgcaacat gcttccctta 2040gtcatttgta ctgaaatcag tttcataagt
tcgttagtgg ttccctaaac gaaaccttgt 2100ttttctttgc aatcaacagg
tcccctaaaa atgcctatgt tgaaggtgat gcctcaagcg 2160caagctattt
cttggctggt gctgcaatta ctggagggac tgtgactgtg gaaggttgtg
2220gcaccaccag tttgcaggta aagatttctt ggctggtgct acgataactg
cttttgtctt 2280tttggtttca gcattgttct cagagtcact aaataacatt
atcatctgca aacgtcaaat 2340agacatactt aggtgaatgg atattcatgt
aaccgtttcc ttacaaattt gctgaaacct 2400cagggtgatg tgaagtttgc
tgaggtactg gagatgatgg gagcgaaggt tacatggacc 2460gagactagcg
taactgttac tggcccaccg cgggagccat ttgggaggaa acacctcaag
2520gcgattgatg tcaacatgaa caagatgcct gatgtcgcca tgactcttgc
tgtggttgcc 2580ctctttgccg atggcccgac agccatcaga gacggtaaaa
cattctcagc cctacaacca 2640tgcctcttct acatcactac ttgacaagac
taaaaactat tggctcgttg gcagtggctt 2700cctggagagt aaaggagacc
gagaggatgg ttgcgatccg gacggagcta accaaggtaa 2760ggctacatac
ttcacatgtc tcacgtcgtc tttccatagc tcgctgcctc ttagcggctt
2820gcctgcggtc gctccatcct cggttgctgt ctgtgttttc cacagctggg
agcatctgtt 2880gaggaagggc cggactactg catcatcacg ccgccggaga
agctgaacgt gacggcgatc 2940gacacgtacg acgaccacag gatggccatg
gccttctccc ttgccgcctg tgccgaggtc 3000cccgtgacca tccgggaccc
tgggtgcacc cggaagacct tccccgacta cttcgatgtg 3060ctgagcactt
tcgtcaagaa ttaataaagc gtgcgatact accacgcagc ttgattgaag
3120tgataggctt gtgctgagga aatacatttc ttttgttctg ttttttctct
ttcacgggat 3180taagttttga gtctgtaacg ttagttgttt gtagcaagtt
tctatttcgg atcttaagtt 3240tgtgcactgt aagccaaatt tcatttcaag
agtggttcgt tggaataata agaataataa 3300attacgtttc agtggctgtc
aagcctgctg ctacgtttta ggagatggca ttagacattc 3360atcatcaaca
acaataaaac cttttagcct caaacaataa tagtgaagtt attttttagt
3420cctaaacaag ttgcattagg atatagttaa aacacaaaag aagctaaagt
tagggtttag 3480acatgtggat attgttttcc atgtatagta tgttctttct
ttgagtctca tttaactacc 3540tctacacata ccaactttag ttttttttct
acctcttcat gttactatgg tgccttctta 3600tcccactgag cattggtata
tttagaggtt tttgttgaac atgcctaaat catctcaatc 3660aacgatggac
aatcttttct tcgattgagc tgaggtacgt catctaga 37085183714DNAZea mays
518ctgcagccca tcaaggagat ctccggcacc gtcaagctgc cggggtccaa
gtcgctttcc 60aacaggatcc tcctgctcgc cgccctgtcc gaggtgagcg attttggtgc
ttgctgcgct 120gccctgtctc actgctacct aaatgttttg cctgtcgaat
accatggatt ctcggtgtaa 180tccatatctg cacgatcaga tatgcaccgc
atgtcgcata tctgagctct ctctaatttg 240tctagtagtt tgtatacgga
ttaagattga taaatcggta ccgcaaaagc taggtgtaaa 300taaacactac
aaaattggat gttcccctat cggcctgtac tcggctactc gttcttgtga
360tggcatgtta tttcttcttg gtgtttggtg aactccctta tgaaatttgg
gcgcaaagaa 420atcgccctca agggttgatc ttatgccatc gtcatgataa
acagtgaagc acggatgatc 480ctttacgttg tttttaacaa actttgtcag
aaaactagca atgttaactt cttaatgatg 540atttcacaac aaaaaaggta
accttgctac taacataaca aaagacttgt tgcttattaa 600ttatatgttt
ttttaatctt tgatcagggg acaacagtgg ttgataacct gttgaacagt
660gaggatgtcc actacatgct cggggccttg aggactcttg gtctctctgt
cgaagcggac 720aaagctgcca aaagagctgt agttgttggc tgtggtggaa
agttcccagt tgaggatgct 780aaagaggaag tgcagctctt cttggggaat
gctggaatcg caatgcggtc attgacagca 840gctgttactg ctgctggtgg
aaatgcaacg tatgtttcct ctctctctct acaatacttg 900ttggagttag
tatgaaaccc atgtgtatgt ctagtggctt atggtgtatt ggtttttgaa
960cttcagttac gtgcttgatg gagtaccaag aatgagggag agacccattg
gcgacttggt 1020tgtcggattg aagcagcttg gtgcagatgt tgattgtttc
cttggcactg actgcccacc 1080tgttcgtgtc aatggaatcg gagggctacc
tggtggcaag gttagttact aagggccaca 1140tgttacattc ttctgtaaat
ggtacaacta ttgtcgagct tttgcatttg taaggaaaac 1200attgattgat
ctgaatttga tgctacacca caaaatatct acaaatggtc atccctaact
1260agcaaaccat gtctccatta agctcaatga agtaatactt ggcatgtgtt
tatcaactta 1320atttccatct tctggggtat tgcctgtttt ctagtctaat
agcatttgtt tttagaatta 1380gctcttacaa ctgttatgtt ctacaggtca
agctgtctgg ctccatcagc agtcagtact 1440tgagtgcctt gctgatggct
gctcctttgg ctcttgggga tgtggagatt gaaatcattg 1500ataaattaat
ctccattccc tacgtcgaaa tgacattgag attgatggag cgttttggtg
1560tgaaagcaga gcattctgat agctgggaca gattctacat taagggaggt
caaaaataca 1620agtaagctct gtaatgtatt tcactacttt gatgccaatg
tttcagtttt cagttttcca 1680aacagtcgca tcaatatttg aatagatgca
ctgtagaaaa aaatcattgc agggaaaaac 1740tagtactgag tattttgact
gtaaattatt taaccagtcg gaatatagtc agtctattgg 1800agtcaagagc
gtgaaccgaa atagccagtt aattatccca ttatacagag gacaaccatg
1860tatactattg aaacttggtt taagagaatc taggtagctg gactcgtagc
tgcttggcat 1920ggataccttc ttatctttag gaaaagacac ttgatttttt
ttctgtggcc ctctatgatg 1980tgtgaacctg cttctctatt gctttagaag
gatatatcta tgtcgttatg caacatgctt 2040cccttagtca tttgtactga
aatcagtttc ataagttcgt tagtggttcc ctaaacgaaa 2100ccttgttttt
ctttgcaatc aacaggtccc ctaaaaatgc ctatgttgaa ggtgatgcct
2160caagcgcaag ctatttcttg gctggtgctg caattactgg agggactgtg
actgtggaag 2220gttgtggcac caccagtttg caggtaaaga tttcttggct
ggtgctacga taactgcttt 2280tgtctttttg gtttcagcat tgttctcaga
gtcactaaat aacattatca tctgcaaacg 2340tcaaatagac atacttaggt
gaatggatat tcatgtaacc gtttccttac aaatttgctg 2400aaacctcagg
gtgatgtgaa gtttgctgag gtactggaga tgatgggagc gaaggttaca
2460tggaccgaga ctagcgtaac tgttactggc ccaccgcggg agccatttgg
gaggaaacac 2520ctcaaggcga ttgatgtcaa catgaacaag atgcctgatg
tcgccatgac tcttgctgtg 2580gttgccctct ttgccgatgg cccgacagcc
atcagagacg gtaaaacatt ctcagcccta 2640caaccatgcc tcttctacat
cactacttga caagactaaa aactattggc tcgttggcag 2700tggcttcctg
gagagtaaag gagaccgaga ggatggttgc gatccggacg gagctaacca
2760aggtaaggct acatacttca catgtctcac gtcgtctttc catagctcgc
tgcctcttag 2820cggcttgcct gcggtcgctc catcctcggt tgctgtctgt
gttttccaca gctgggagca 2880tctgttgagg aagggccgga ctactgcatc
atcacgccgc cggagaagct gaacgtgacg 2940gcgatcgaca cgtacgacga
ccacaggatg gccatggcct tctcccttgc cgcctgtgcc 3000gaggtccccg
tgaccatccg ggaccctggg tgcacccgga agaccttccc cgactacttc
3060gatgtgctga gcactttcgt caagaattaa taaagcgtgc gatactacca
cgcagcttga 3120ttgaagtgat aggcttgtgc tgaggaaata catttctttt
gttctgtttt ttctctttca 3180cgggattaag ttttgagtct gtaacgttag
ttgtttgtag caagtttcta tttcggatct 3240taagtttgtg cactgtaagc
caaatttcat ttcaagagtg gttcgttgga ataataagaa 3300taataaatta
cgtttcagtg gctgtcaagc ctgctgctac gttttaggag atggcattag
3360acattcatca tcaacaacaa taaaaccttt tagcctcaaa caataatagt
gaagttattt 3420tttagtccta aacaagttgc attaggatat agttaaaaca
caaaagaagc taaagttagg 3480gtttagacat gtggatattg ttttccatgt
atagtatgtt ctttctttga gtctcattta 3540actacctcta cacataccaa
ctttagtttt ttttctacct cttcatgtta ctatggtgcc 3600ttcttatccc
actgagcatt ggtatattta gaggtttttg ttgaacatgc ctaaatcatc
3660tcaatcaacg atggacaatc ttttcttcga ttgagctgag gtacgtcatc taga
37145193708DNAZea mays 519ctgcagccca tcaaggagat ctccggcacc
gtcaagctgc cggggtccaa gtcgctttcc 60aacaggatcc tcctgctcgc cgccctgtcc
gaggtgagcg attttggtgc ttgctgcgct 120gccctgtctc actgctacct
aaatgttttg cctgtcgaat accatggatt ctcggtgtaa 180tccatctcac
gatcagatgc accgcatgtc gcatgcctag ctctctctaa tttgtctagt
240agtttgtata cggattaaga ttgataaatc ggtaccgcaa aagctaggtg
taaataaaca 300ctacaaaatt ggatgttccc ctatcggcct gtactcggct
actcgttctt gtgatggcat 360gttatttctt cttggtgttt ggtgaactcc
cttatgaaat ttgggcgcaa agaaatcgcc 420ctcaagggtt gatcttatgc
catcgtcatg ataaacagtg aagcacggat gatcctttac 480gttgttttta
acaaactttg tcagaaaact agcaatgtta acttcttaat gatgatttca
540caacaaaaaa ggtaaccttg ctactaacat aacaaaagac ttgttgctta
ttaattatat 600gtttttttaa tctttgatca ggggacaaca gtggttgata
acctgttgaa cagtgaggat 660gtccactaca tgctcggggc cttgaggact
cttggtctct ctgtcgaagc ggacaaagct 720gccaaaagag ctgtagttgt
tggctgtggt ggaaagttcc cagttgagga tgctagaaag 780gaagtgcagc
tcttcttggg gaatgctgga atcgcaatgc ggtcattgac agcagctgtt
840actgctgctg gtggaaatgc aacgtatgtt tcctctctct ctctacaata
cttgttggag 900ttagtatgaa acccatgtgt atgtctagtg gcttatggtg
tattggtttt tgaacttcag 960gtacgtgctt gatggagtac caagaatgag
ggagagaccc attggcgact tggttgtcgg 1020attgaagcag cttggtgcag
atgttgattg tttccttggc actgactgcc cacctgttcg 1080tgtcaatgga
atcggagggc tacctggtgg caaggttagt tactaagggc cacatgttac
1140attcttctgt aaatggtaca actattgtcg agcttttgca tttgtaagga
aaacattgat 1200tgatctgaat ttgatgctac accacaaaat atctacaaat
ggtcatccct aactagcaaa 1260ccatgtctcc attaagctca atgaagtaat
acttggcatg tgtttatcaa cttaatttcc 1320atcttctggg gtattgcctg
ttttctagtc taatagcatt tgtttttaga attagctctt 1380acaactgtta
tgttctacag gtcaagctgt ctggctccat cagcagtcag tacttgagtg
1440ccttgctgat ggctgctcct ttggctcttg gggatgtgga gattgaaatc
attgataaat 1500taatctccat tccctacgtc gaaatgacat tgagattgat
ggagcgtttt ggtgtgaaag 1560cagagcattc tgatagctgg gacagattct
acattaaggg aggtcaaaaa tacaagtaag 1620ctctgtaatg tatttcacta
ctttgatgcc aatgtttcag ttttcagttt tccaaacagt 1680cgcatcaata
tttgaataga tgcactgtag aaaaaaatca ttgcagggaa aaactagtac
1740tgagtatttt gactgtaaat tatttaacca gtcggaatat agtcagtcta
ttggagtcaa 1800gagcgtgaac cgaaatagcc agttaattat cccattatac
agaggacaac catgtatact 1860attgaaactt ggtttaagag aatctaggta
gctggactcg tagctgcttg gcatggatac 1920cttcttatct ttaggaaaag
acacttgatt ttttttctgt ggccctctat gatgtgtgaa 1980cctgcttctc
tattgcttta gaaggatata tctatgtcgt tatgcaacat gcttccctta
2040gtcatttgta ctgaaatcag tttcataagt tcgttagtgg ttccctaaac
gaaaccttgt 2100ttttctttgc aatcaacagg tcccctaaaa atgcctatgt
tgaaggtgat gcctcaagcg 2160caagctattt cttggctggt gctgcaatta
ctggagggac tgtgactgtg gaaggttgtg 2220gcaccaccag tttgcaggta
aagatttctt ggctggtgct acgataactg cttttgtctt 2280tttggtttca
gcattgttct cagagtcact aaataacatt atcatctgca aacgtcaaat
2340agacatactt aggtgaatgg atattcatgt aaccgtttcc ttacaaattt
gctgaaacct 2400cagggtgatg tgaagtttgc tgaggtactg gagatgatgg
gagcgaaggt tacatggacc 2460gagactagcg taactgttac tggcccaccg
cgggagccat ttgggaggaa acacctcaag 2520gcgattgatg tcaacatgaa
caagatgcct gatgtcgcca tgactcttgc tgtggttgcc
2580ctctttgccg atggcccgac agccatcaga gacggtaaaa cattctcagc
cctacaacca 2640tgcctcttct acatcactac ttgacaagac taaaaactat
tggctcgttg gcagtggctt 2700cctggagagt aaaggagacc gagaggatgg
ttgcgatccg gacggagcta accaaggtaa 2760ggctacatac ttcacatgtc
tcacgtcgtc tttccatagc tcgctgcctc ttagcggctt 2820gcctgcggtc
gctccatcct cggttgctgt ctgtgttttc cacagctggg agcatctgtt
2880gaggaagggc cggactactg catcatcacg ccgccggaga agctgaacgt
gacggcgatc 2940gacacgtacg acgaccacag gatggccatg gccttctccc
ttgccgcctg tgccgaggtc 3000cccgtgacca tccgggaccc tgggtgcacc
cggaagacct tccccgacta cttcgatgtg 3060ctgagcactt tcgtcaagaa
ttaataaagc gtgcgatact accacgcagc ttgattgaag 3120tgataggctt
gtgctgagga aatacatttc ttttgttctg ttttttctct ttcacgggat
3180taagttttga gtctgtaacg ttagttgttt gtagcaagtt tctatttcgg
atcttaagtt 3240tgtgcactgt aagccaaatt tcatttcaag agtggttcgt
tggaataata agaataataa 3300attacgtttc agtggctgtc aagcctgctg
ctacgtttta ggagatggca ttagacattc 3360atcatcaaca acaataaaac
cttttagcct caaacaataa tagtgaagtt attttttagt 3420cctaaacaag
ttgcattagg atatagttaa aacacaaaag aagctaaagt tagggtttag
3480acatgtggat attgttttcc atgtatagta tgttctttct ttgagtctca
tttaactacc 3540tctacacata ccaactttag ttttttttct acctcttcat
gttactatgg tgccttctta 3600tcccactgag cattggtata tttagaggtt
tttgttgaac atgcctaaat catctcaatc 3660aacgatggac aatcttttct
tcgattgagc tgaggtacgt catctaga 3708520464PRTzea mays 520Met Gln Leu
Asp Leu Asn Val Ala Glu Ala Pro Pro Pro Val Glu Met 1 5 10 15 Glu
Ala Ser Asp Ser Gly Ser Ser Val Leu Asn Ala Ser Glu Ala Ala 20 25
30 Ser Ala Gly Gly Ala Pro Ala Pro Ala Glu Glu Gly Ser Ser Ser Thr
35 40 45 Pro Ala Val Leu Glu Phe Ser Ile Leu Ile Arg Ser Asp Ser
Asp Ala 50 55 60 Ala Gly Ala Asp Glu Asp Glu Asp Ala Thr Pro Ser
Pro Pro Pro Arg 65 70 75 80 His Arg His Gln His Gln Gln Gln Leu Val
Thr Arg Glu Leu Phe Pro 85 90 95 Ala Gly Ala Gly Pro Pro Ala Pro
Thr Pro Arg His Trp Ala Glu Leu 100 105 110 Gly Phe Phe Arg Ala Asp
Leu Gln Gln Gln Gln Ala Pro Gly Pro Arg 115 120 125 Ile Val Pro His
Pro His Ala Ala Pro Pro Pro Ala Lys Lys Ser Arg 130 135 140 Arg Gly
Pro Arg Ser Arg Ser Ser Gln Tyr Arg Gly Val Thr Phe Tyr 145 150 155
160 Arg Arg Thr Gly Arg Trp Glu Ser His Ile Trp Asp Cys Gly Lys Gln
165 170 175 Val Tyr Leu Gly Gly Phe Asp Thr Ala His Ala Ala Ala Arg
Ala Tyr 180 185 190 Asp Arg Ala Ala Ile Lys Phe Arg Gly Val Asp Ala
Asp Ile Asn Phe 195 200 205 Asn Leu Ser Asp Tyr Glu Asp Asp Met Lys
Gln Met Gly Ser Leu Ser 210 215 220 Lys Glu Glu Phe Val His Val Leu
Arg Arg Gln Ser Thr Gly Phe Ser 225 230 235 240 Arg Gly Ser Ser Arg
Tyr Arg Gly Val Thr Leu His Lys Cys Gly Arg 245 250 255 Trp Glu Ala
Arg Met Gly Gln Phe Leu Gly Lys Lys Tyr Ile Tyr Leu 260 265 270 Gly
Leu Phe Asp Ser Glu Val Glu Ala Ala Arg Ala Tyr Asp Lys Ala 275 280
285 Ala Ile Lys Cys Asn Gly Arg Glu Ala Val Thr Asn Phe Glu Pro Ser
290 295 300 Thr Tyr His Gly Glu Leu Pro Thr Glu Val Ala Asp Val Asp
Leu Asn 305 310 315 320 Leu Ser Ile Ser Gln Pro Ser Pro Gln Arg Asp
Lys Asn Ser Cys Leu 325 330 335 Gly Leu Gln Leu His His Gly Pro Phe
Glu Gly Ser Glu Leu Lys Lys 340 345 350 Thr Lys Ile Asp Asp Ala Pro
Ser Glu Leu Pro Gly Arg Pro Arg Gln 355 360 365 Leu Ser Pro Leu Val
Ala Glu His Pro Pro Ala Trp Pro Ala Gln Pro 370 375 380 Pro His Pro
Phe Phe Val Phe Thr Asn His Glu Met Ser Ala Ser Gly 385 390 395 400
Asp Leu His Arg Arg Pro Ala Gly Ala Val Pro Ser Trp Ala Trp Gln 405
410 415 Val Ala Ala Ala Ala Pro Pro Pro Ala Ala Leu Pro Ser Ser Ala
Ala 420 425 430 Ala Ser Ser Gly Phe Ser Asn Thr Ala Thr Thr Ala Ala
Thr Thr Ala 435 440 445 Pro Ser Ala Ser Ser Leu Arg Tyr Cys Pro Pro
Pro Pro Pro Pro Ser 450 455 460 5211413DNAZea mays 521atgcagttgg
atctgaacgt ggccgaggcg ccgccgccgg tggagatgga ggcgagcgac 60tcggggtcgt
cggtgctgaa cgcgtcggaa gcggcgtcgg cgggcggcgc gcccgcgccg
120gcggaggagg gatctagctc aacgccggcc gtgctggagt tcagcatcct
catccggagc 180gatagcgacg cggccggcgc ggacgaggac gaggacgcca
cgccatcgcc tcctcctcgc 240caccgccacc agcaccagca gcagctcgtg
acccgcgagc tgttcccggc cggcgccggt 300ccgccggccc cgacgccgcg
gcattgggcc gagctcggct tcttccgcgc cgacctgcag 360cagcaacagg
cgccgggccc caggatcgtg ccgcacccac acgccgcgcc gccgccggcc
420aagaagagcc gccgcggccc gcgctcccgc agctcgcagt accgcggcgt
caccttctac 480cgccgcacag gccgctggga gtcccacatc tgggattgcg
gcaagcaggt gtacctaggt 540ggattcgaca ccgctcacgc cgctgcaagg
gcgtacgacc gggcggcgat caagttccgc 600ggcgtcgacg ccgacatcaa
cttcaacctc agcgactacg aggacgacat gaagcagatg 660gggagcctgt
ccaaggagga gttcgtgcac gtcctgcgcc gtcagagcac cggcttctcg
720agaggcagct ccaggtacag aggcgtcacc ctgcacaagt gcggccgctg
ggaggcgcgc 780atggggcagt tcctcggcaa gaagtacata taccttgggc
tattcgacag cgaagtagag 840gctgcaagag cctacgacaa ggccgccatc
aaatgcaatg gcagagaggc cgtgacgaac 900ttcgagccga gcacgtatca
cggggagctg ccgactgaag ttgctgatgt cgatctgaac 960ctgagcatat
ctcagccgag cccccaaaga gacaagaaca gctgcctagg tctgcagctc
1020caccacggac cattcgaggg ctccgaactg aagaaaacca agatcgacga
tgctccctct 1080gagctaccgg gccgccctcg tcagctgtct cctctcgtgg
ctgagcatcc gccggcctgg 1140cctgcgcagc cgcctcaccc cttcttcgtc
ttcacaaacc atgagatgag tgcatcagga 1200gatctccaca ggaggcctgc
aggggctgtt cccagctggg catggcaggt ggcagcagca 1260gctcctcctc
ctgccgccct gccgtcgtcc gctgcagcat catcaggatt ctccaacacc
1320gccacgacag ctgccaccac cgccccatcg gcctcctccc tccggtactg
cccgccgccg 1380ccgccgccgt cgagccatca ccatccccgc tga
1413522514PRTZea Mays 522Met Thr Thr Ser Thr Thr Ala Lys Gln Leu
Arg Arg Val Arg Thr Leu 1 5 10 15 Gly Arg Gly Ala Ser Gly Ala Val
Val Trp Leu Ala Ser Asp Glu Ala 20 25 30 Ser Gly Glu Leu Val Ala
Val Lys Ser Ala Arg Ala Ala Gly Ala Ala 35 40 45 Ala Gln Leu Gln
Arg Glu Gly Arg Val Leu Arg Gly Leu Ser Ser Pro 50 55 60 His Ile
Val Pro Cys Leu Gly Ser Arg Ala Ala Ala Gly Gly Glu Tyr 65 70 75 80
Gln Leu Leu Leu Glu Phe Ala Pro Gly Gly Ser Leu Ala Asp Glu Ala 85
90 95 Ala Arg Ser Gly Gly Gly Arg Leu Ala Glu Arg Ala Ile Gly Ala
Tyr 100 105 110 Ala Gly Asp Val Ala Arg Gly Leu Ala Tyr Leu His Gly
Arg Ser Leu 115 120 125 Val His Gly Asp Val Lys Ala Arg Asn Val Val
Ile Gly Gly Asp Gly 130 135 140 Arg Ala Arg Leu Thr Asp Phe Gly Cys
Ala Arg Pro Ala Gly Gly Ser 145 150 155 160 Thr Arg Pro Val Gly Gly
Thr Pro Ala Phe Met Ala Pro Glu Val Ala 165 170 175 Arg Gly Gln Glu
Gln Gly Pro Ala Ala Asp Val Trp Ala Leu Gly Cys 180 185 190 Met Val
Val Glu Leu Ala Thr Gly Arg Ala Pro Trp Ser Asp Val Glu 195 200 205
Gly Asp Asp Leu Leu Ala Ala Leu His Arg Ile Gly Tyr Thr Asp Asp 210
215 220 Val Pro Glu Val Pro Ala Trp Leu Ser Pro Glu Ala Lys Asp Phe
Leu 225 230 235 240 Ala Gly Cys Phe Glu Arg Arg Ala Ala Ala Arg Pro
Thr Ala Ala Gln 245 250 255 Pro Ala Ala His Pro Phe Val Val Ala Ser
Ala Ser Ala Ala Ala Ala 260 265 270 Ile Arg Gly Pro Ala Lys Gln Glu
Val Val Pro Ser Pro Lys Ser Thr 275 280 285 Leu His Asp Ala Phe Trp
Asp Ser Asp Ala Glu Asp Glu Ala Asp Glu 290 295 300 Met Ser Thr Gly
Ala Ala Ala Glu Arg Ile Gly Ala Leu Ala Cys Ala 305 310 315 320 Ala
Ser Ala Leu Pro Asp Trp Asp Thr Glu Glu Gly Trp Ile Asp Leu 325 330
335 Gln Asp Asp His Ser Ala Gly Thr Ala Asp Ala Pro Pro Ala Pro Val
340 345 350 Ala Asp Tyr Phe Ile Ser Trp Ala Glu Pro Ser Asp Ala Glu
Leu Glu 355 360 365 Pro Phe Val Ala Val Ala Ala Ala Ala Gly Leu Pro
His Val Ala Gly 370 375 380 Val Ala Leu Ala Gly Ala Thr Ala Val Asn
Leu Gln Gly Ser Tyr Tyr 385 390 395 400 Tyr Tyr Pro Pro Met His Leu
Gly Val Arg Gly Asn Glu Ile Pro Arg 405 410 415 Pro Leu Leu Asp His
His Gly Asp Gly Leu Glu Lys Gly Gln Gly Ser 420 425 430 His Arg Val
Cys Asn Arg Glu Thr Glu Lys Val Thr Met Lys Arg Ile 435 440 445 Ser
Leu Lys Arg Arg Ala Ala Phe Leu Leu Asp Gln His His Val Arg 450 455
460 Ser Leu Asp Lys Leu Glu Tyr Arg Pro Arg His Asp Arg Met Leu Arg
465 470 475 480 Arg Arg Gln Ser Ile Tyr Arg Ser Asn Ser Val Leu Gly
Tyr Asp Val 485 490 495 Ser Lys Gly Arg Gln Val Arg Trp Arg Arg Ala
Val Cys Ile Ala Val 500 505 510 Ala Ala 5231545DNAZea mays
523atgacgacgt cgaccacggc gaagcagctc cggcgcgtgc gcacgctcgg
ccgcggcgcg 60tcgggcgccg tggtgtggct ggcctccgac gaggcctcgg gcgagctggt
ggcggtcaag 120tcggcgcgcg ccgccggggc cgcggcgcag ctgcagcgcg
agggccgcgt cctccggggc 180ctctcgtcgc cgcacatcgt gccctgcctc
ggctcccgcg ccgcggcggg cggcgagtac 240cagctcctgc tggagttcgc
gccgggcggg tcgctggccg acgaggccgc caggagcggc 300gggggccgcc
tcgcggagcg cgccatcggc gcctacgccg gggacgtggc gcgcgggctg
360gcgtacctcc acggccggtc gctcgtgcac ggggacgtca aggcccggaa
cgtggtcatc 420ggcggcgacg ggcgcgccag gctgaccgac ttcgggtgcg
cgaggccggc cggcgggtcg 480acgcgccccg tcgggggcac cccggcgttc
atggcgcccg aggtggcgcg cggccaggag 540cagggccccg ccgccgacgt
ctgggcgctc gggtgcatgg tcgtcgagct ggccacgggc 600cgcgcgccct
ggagcgacgt ggagggcgac gacctcctcg ccgcgctcca ccggatcggg
660tacacggacg acgtgccgga ggtgcccgcg tggctgtcgc ccgaggccaa
ggacttcctg 720gccggctgct tcgagcgccg cgccgccgcc cggcccacgg
ccgcgcagcc cgcggcgcac 780ccgttcgtcg tcgcctccgc ctccgccgcc
gccgccatcc gcggcccggc gaagcaggag 840gtggtcccgt cacccaagag
cacgctgcac gacgcgttct gggactcgga cgccgaggac 900gaagcggacg
agatgtcgac gggcgcggcg gccgagagga tcggggcatt ggcgtgcgcc
960gcctccgcgc tgcctgactg ggacaccgag gaaggctgga tcgacctcca
ggacgaccac 1020tcggccggaa ctgccgacgc accgccggcg cccgtcgcgg
actacttcat cagctgggcg 1080gagccgtcag acgcagagct ggaaccattc
gtcgccgtcg ccgccgccgc aggtctcccg 1140cacgttgcag gagttgcatt
agcaggcgcc accgccgtta acctgcaggg cagttattat 1200tattacccgc
ctatgcatct aggcgtccgc ggaaacgaga ttccacgccc gttgttggat
1260catcatggcg acgggttaga aaaggggcag ggatcccacc gcgtttgtaa
cagagaaaca 1320gaaaaggtaa caatgaaacg aatttcgtta aaaagaagag
ctgctttcct tctcgaccag 1380catcacgtgc gatcgctgga caaactggaa
tatcgtccac gtcacgaccg aatgctgcgt 1440cgacggcaat ctatatatcg
gagcaatagc gtccttggtt acgacgttag caaaggtagg 1500caggtccgtt
ggcgccgtgc ggtttgcatt gccgttgctg cctga 1545524671DNAzea mays
524cggatccact agtaacggcc gccagtgtgc tggaattcgc ccttgacggc
ccgggctggt 60atttcaaaac tatagtattt taaaattgca ttaacaaaca tgtcctaatt
ggtactcctg 120agatactata ccctcctgtt ttaaaatagt tggcattatc
gaattatcat tttacttttt 180aatgttttct cttcttttaa tatattttat
gaattttaat gtattttaaa atgttatgca 240gttcgctctg gacttttctg
ctgcgcctac acttgggtgt actgggccta aattcagcct 300gaccgaccgc
ctgcattgaa taatggatga gcaccggtaa aatccgcgta cccaactttc
360gagaagaacc gagacgtggc gggccgggcc accgacgcac ggcaccagcg
actgcacacg 420tcccgccggc gtacgtgtac gtgctgttcc ctcactggcc
gcccaatcca ctcatgcatg 480cccacgtaca cccctgccgt ggcgcgccca
gatcctaatc ctttcgccgt tctgcacttc 540tgctgcctat aaatggcggc
atcgaccgtc acctgcttca ccaccggcga gccacatcga 600gaacacgatc
gagcacacaa gcacgaagac tcgtttagga gaaaccacaa accaccaagc
660cgtgcaagca c 671525245PRTzea mays 525Met Gly Arg Gly Lys Val Gln
Leu Lys Arg Ile Glu Asn Lys Ile Asn 1 5 10 15 Arg Gln Val Thr Phe
Ser Lys Arg Arg Ser Gly Leu Leu Lys Lys Ala 20 25 30 His Glu Ile
Ser Val Leu Cys Asp Ala Glu Val Ala Leu Ile Ile Phe 35 40 45 Ser
Thr Lys Gly Lys Leu Tyr Glu Tyr Ser Thr Asp Ser Cys Met Asp 50 55
60 Lys Ile Leu Glu Arg Tyr Glu Arg Tyr Ser Tyr Ala Glu Lys Val Leu
65 70 75 80 Ile Ser Ala Glu Tyr Glu Thr Gln Gly Asn Trp Cys His Glu
Tyr Arg 85 90 95 Lys Leu Lys Ala Lys Val Glu Thr Ile Gln Lys Cys
Gln Lys His Leu 100 105 110 Met Gly Glu Asp Leu Glu Thr Leu Asn Leu
Lys Glu Leu Gln Gln Leu 115 120 125 Glu Gln Gln Leu Glu Ser Ser Leu
Lys His Ile Arg Thr Arg Lys Ser 130 135 140 Gln Leu Met Val Glu Ser
Ile Ser Ala Leu Gln Arg Lys Glu Lys Ser 145 150 155 160 Leu Gln Glu
Glu Asn Lys Val Leu Gln Lys Glu Leu Ala Glu Lys Gln 165 170 175 Lys
Asp Gln Arg Gln Gln Val Gln Arg Asp Gln Thr Gln Gln Gln Thr 180 185
190 Ser Ser Ser Ser Thr Ser Phe Met Leu Arg Glu Ala Ala Pro Thr Thr
195 200 205 Asn Val Ser Ile Phe Pro Val Ala Ala Gly Gly Arg Val Val
Glu Gly 210 215 220 Ala Ala Ala Gln Pro Gln Ala Arg Val Gly Leu Pro
Pro Trp Met Leu 225 230 235 240 Ser His Leu Ser Cys 245
526738DNAzea mays 526atggggcgcg ggaaggtgca gctgaagcgg atcgagaaca
agatcaaccg ccaggtgaca 60ttctccaagc gccgctcggg gctactcaag aaggcgcacg
agatctccgt gctctgcgac 120gccgaggtcg cgctcatcat cttctccacc
aagggcaagc tctacgagta ctctaccgat 180tcatgtatgg acaaaattct
tgaacggtat gagcgctact cctatgcaga aaaggttctc 240atttccgcag
aatatgaaac tcagggcaat tggtgccatg aatatagaaa actaaaggcg
300aaggtcgaga caatacagaa atgtcaaaag cacctcatgg gagaggatct
tgaaactttg 360aatctcaaag agcttcagca actagagcag cagctggaga
gttcactgaa acatatcaga 420acaaggaaga gccagcttat ggtcgagtca
atttcagcgc tccaacggaa ggagaagtca 480ctgcaggagg agaacaaggt
tctgcagaag gagctcgcgg agaagcagaa agaccagcgg 540cagcaagtgc
aacgggacca aactcaacag cagaccagtt cgtcttccac gtccttcatg
600ttaagggaag ctgccccaac aacaaatgtc agcatcttcc ctgtggcagc
aggcgggagg 660gtggtggaag gggcagcagc gcagccgcag gctcgcgttg
gactgccacc atggatgctt 720agccatctga gctgctga 73852780DNAzea
maysmisc_feature(1)..(80)sequence of Figure 34B 527gctaaagagg
aagtgcagct cttcttgggg aatgctggaa ctgcaatgcg gccattgaca 60gcagctgtta
ctgctgctgg 8052880DNAzea maysmisc_feature(1)..(80)sequence of
Figure 34c 528gctagagagg aagtgcagct cttcttgggg aatgctggaa
tcgcaatgcg gtcattgaca 60gcagctgtta ctgctgctgg 8052937DNAzea
maysmisc_feature(1)..(37)sequence of Figure 35b 529catctcacga
tcagatgcac cgcatgtcgc atgccta 3753042DNAzea
maysmisc_feature(1)..(42)sequence of Figure 35c 530catatctgca
cgatcagata tgcaccgcat gtcgcatatc tg 4253131DNAzea
maysmisc_feature(1)..(31)sequence of Figure 37 531gtttttgaac
ttcagttacg tgcttgatgg a 3153231DNAzea
maysmisc_feature(1)..(31)sequence of Figure 37 532gtttttgaac
ttcaggtacg tgcttgatgg a 31533459DNAArtificial SequenceSouthern
genomic probe 533agctttatcc atccatccat cgcgctagct ggctgcaggc
acgggttatc ttatcttgtc 60gtccagagga cgacacacgg ccggccggtg aagtaaaagg
gagtaatctt attttgccag 120gacgaggggc ggtacatgat attacacacg
taccatgcat gcatatatgc atggacaagg 180tacgtcgtcg tcgatcgacg
tcgatgcata tgtgtgtatg tatgtacgtg cataatgcat 240ggtaccagct
gctggcttat atatatttgt caccgatcga tgcatgctgc tgctctacac
300ggtttgacac tttaatttga ctcatcgatg accttgctag atagtagcgg
ctcgtcaatt 360aatgagccat caagttaaca agagggcacg ggcttgcgcg
actgattcca ccttattaac 420atacgccctg
cgcccgcgcg tgctgtacgt acgagaatt 459534446DNAArtificial
SequenceSouthern MoPAT probe 534tcgaagtcgc gctgccagaa gccgacgtcg
tgccagccgc cgtgcttgta gccggcggcg 60cggagggtgc cgcgggcggt gtagccgagg
gcctcgtgga ggcgcacgga cgggtcgttc 120gggaggccga tcacggccac
cacggacttg aagccctggg cctccatgct cttgaggagg 180tgggtgtaga
gggtggagcc gaggccgagg cgctggtggc ggtgggacac gtacacggtg
240gactccacgg tccagtcgta ggcgttgcgg gccttccacg ggccggcgta
ggcgatgccg 300gccaccacgc cctccacctc ggccacgagc cacgggtagc
ggtcctggag gcgctccagg 360tcgtcgatcc actcctgcgg ggtctgcggc
tcggtgcgga agttcacggt ggaggtctcg 420atgtagtggt tcacgatgtc gcacac
44653520DNAArtificial SequenceRF-FPCas-1 535gcaggtctca cgacggttgg
2053623DNAArtificial SequenceRF-FPCas-2 536gtaaagtacg cgtacgtgtg
agg 2353723DNAArtificial SequenceALSCas-4 537gctgctcgat tccgtcccca
tgg 23538804DNAArtificial SequenceALS modification repair template
804 538agcttacagc cgccgcaacc atggccaccg ccgccgccgc gtctaccgcg
ctcactggcg 60ccactaccgc tgcgcccaag gcgaggcgcc gggcgcacct cctggccacc
cgccgcgccc 120tcgccgcgcc catcaggtgc tcagcggcgt cacccgccat
gccgatggct cccccggcca 180ccccgctccg gccgtggggc cccaccgatc
cccgcaaggg cgccgacatc ctcgtcgagt 240ccctcgagcg ctgcggcgtc
cgcgacgtct tcgcctaccc cggcggcgcg tccatggaga 300tccaccaggc
actcacccgc tcccccgtca tcgccaacca cctcttccgc cacgagcaag
360gggaggcctt tgcggcctcc ggctacgcgc gctcctcggg ccgcgtcggc
gtctgcatcg 420ccacctccgg ccccggcgcc accaaccttg tctccgcgct
cgccgacgcg ttgctcgact 480ccgtccccat tgtcgccatc acgggacagg
tgtcgcgacg catgattggc accgacgcct 540tccaggagac gcccatcgtc
gaggtcaccc gctccatcac caagcacaac tacctggtcc 600tcgacgtcga
cgacatcccc cgcgtcgtgc aggaggcttt cttcctcgcc tcctctggtc
660gaccagggcc ggtgcttgtc gacatcccca aggacatcca gcagcagatg
gcggtgcctg 720tctgggacaa gcccatgagt ctgcctgggt acattgcgcg
ccttcccaag ccccctgcga 780ctgagttgct tgagcagaag ggcg
804539127DNAArtificial SequenceALS modification repair template 127
539aaccttgtct ccgcgctcgc cgacgcgttg ctcgactccg tccccattgt
cgccatcacg 60ggacaggtgt cgcgacgcat gattggcacc gacgccttcc aggagacgcc
catcgtcgag 120gtcaccc 12754025DNAArtificial SequenceALS
Forward_primer; 540ctacgcacat ccccctttct cccac 2554136DNAArtificial
SequenceALS Reverse_primer 541atgcatacct agcatgcgca gagacagtgg
gtcgtc 3654222DNAArtificial sequencesoy ALS1-CR1, Cas9 target
sequence 542caccggccag gtcccccgcc gg 2254322DNAArtificial
sequencesoy ALS2-CR2, Cas9 target sequence 543ggcgtcggtg ccgatcatcc
gg 225449093DNAArtificial sequenceQC880 544ccgggtgtga tttagtataa
agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta 60cctagtaata agtaatattg
aacaaaataa atggtaaagt gtcagatata taaaataggc 120tttaataaaa
ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc agagcagagt
180catcatgaag ctagaaaggc taccgataga taaactatag ttaattaaat
acattaaaaa 240atacttggat ctttctctta ccctgtttat attgagacct
gaaacttgag agagatacac 300taatcttgcc ttgttgtttc attccctaac
ttacaggact cagcgcatgt catgtggtct 360cgttccccat ttaagtccca
caccgtctaa acttattaaa ttattaatgt ttataactag 420atgcacaaca
acaaagcttg caccggccag gtcccccgcg ttttagagct agaaatagca
480agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc
ggtgcttttt 540tttgcggccg caattggatc gggtttactt attttgtggg
tatctatact tttattagat 600ttttaatcag gctcctgatt tctttttatt
tcgattgaat tcctgaactt gtattattca 660gtagatcgaa taaattataa
aaagataaaa tcataaaata atattttatc ctatcaatca 720tattaaagca
atgaatatgt aaaattaatc ttatctttat tttaaaaaat catataggtt
780tagtattttt ttaaaaataa agataggatt agttttacta ttcactgctt
attactttta 840aaaaaatcat aaaggtttag tattttttta aaataaatat
aggaatagtt ttactattca 900ctgctttaat agaaaaatag tttaaaattt
aagatagttt taatcccagc atttgccacg 960tttgaacgtg agccgaaacg
atgtcgttac attatcttaa cctagctgaa acgatgtcgt 1020cataatatcg
ccaaatgcca actggactac gtcgaaccca caaatcccac aaagcgcgtg
1080aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt gttacacgct
caatcccacg 1140cgagtagagc acagtaacct tcaaataagc gaatggggca
taatcagaaa tccgaaataa 1200acctaggggc attatcggaa atgaaaagta
gctcactcaa tataaaaatc taggaaccct 1260agttttcgtt atcactctgt
gctccctcgc tctatttctc agtctctgtg tttgcggctg 1320aggattccga
acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc tgctcttgtc
1380tcttcgattc gatctatgcc tgtctcttat ttacgatgat gtttcttcgg
ttatgttttt 1440ttatttatgc tttatgctgt tgatgttcgg ttgtttgttt
cgctttgttt ttgtggttca 1500gttttttagg attcttttgg tttttgaatc
gattaatcgg aagagatttt cgagttattt 1560ggtgtgttgg aggtgaatct
tttttttgag gtcatagatc tgttgtattt gtgttataaa 1620catgcgactt
tgtatgattt tttacgaggt tatgatgttc tggttgtttt attatgaatc
1680tgttgagaca gaaccatgat ttttgttgat gttcgtttac actattaaag
gtttgtttta 1740acaggattaa aagtttttta agcatgttga aggagtcttg
tagatatgta accgtcgata 1800gtttttttgt gggtttgttc acatgttatc
aagcttaatc ttttactatg tatgcgacca 1860tatctggatc cagcaaaggc
gattttttaa ttccttgtga aacttttgta atatgaagtt 1920gaaattttgt
tattggtaaa ctataaatgt gtgaagttgg agtatacctt taccttctta
1980tttggctttg tgatagttta atttatatgt attttgagtt ctgacttgta
tttctttgaa 2040ttgattctag tttaagtaat ccatggacaa aaagtactca
atagggctcg acatagggac 2100taactccgtt ggatgggccg tcatcaccga
cgagtacaag gtgccctcca agaagttcaa 2160ggtgttggga aacaccgaca
ggcacagcat aaagaagaat ttgatcggtg ccctcctctt 2220cgactccgga
gagaccgctg aggctaccag gctcaagagg accgctagaa ggcgctacac
2280cagaaggaag aacagaatct gctacctgca ggagatcttc tccaacgaga
tggccaaggt 2340ggacgactcc ttcttccacc gccttgagga atcattcctg
gtggaggagg ataaaaagca 2400cgagagacac ccaatcttcg ggaacatcgt
cgacgaggtg gcctaccatg aaaagtaccc 2460taccatctac cacctgagga
agaagctggt cgactctacc gacaaggctg acttgcgctt 2520gatttacctg
gctctcgctc acatgataaa gttccgcgga cacttcctca ttgagggaga
2580cctgaaccca gacaactccg acgtggacaa gctcttcatc cagctcgttc
agacctacaa 2640ccagcttttc gaggagaacc caatcaacgc cagtggagtt
gacgccaagg ctatcctctc 2700tgctcgtctg tcaaagtcca ggaggcttga
gaacttgatt gcccagctgc ctggcgaaaa 2760gaagaacgga ctgttcggaa
acttgatcgc tctctccctg ggattgactc ccaacttcaa 2820gtccaacttc
gacctcgccg aggacgctaa gttgcagttg tctaaagaca cctacgacga
2880tgacctcgac aacttgctgg cccagatagg cgaccaatac gccgatctct
tcctcgccgc 2940taagaacttg tccgacgcaa tcctgctgtc cgacatcctg
agagtcaaca ctgagattac 3000caaagctcct ctgtctgctt ccatgattaa
gcgctacgac gagcaccacc aagatctgac 3060cctgctcaag gccctggtga
gacagcagct gcccgagaag tacaaggaga tctttttcga 3120ccagtccaag
aacggctacg ccggatacat tgacggaggc gcctcccagg aagagttcta
3180caagttcatc aagcccatcc ttgagaagat ggacggtacc gaggagctgt
tggtgaagtt 3240gaacagagag gacctgttga ggaagcagag aaccttcgac
aacggaagca tccctcacca 3300aatccacctg ggagagctcc acgccatctt
gaggaggcag gaggatttct atcccttcct 3360gaaggacaac cgcgagaaga
ttgagaagat cttgaccttc agaattcctt actacgtcgg 3420gccactcgcc
agaggaaact ctaggttcgc ctggatgacc cgcaaatctg aagagaccat
3480tactccctgg aacttcgagg aagtcgtgga caagggcgct tccgctcagt
ctttcatcga 3540gaggatgacc aacttcgata aaaatctgcc caacgagaag
gtgctgccca agcactccct 3600gttgtacgag tatttcacag tgtacaacga
gctcaccaag gtgaagtacg tcacagaggg 3660aatgaggaag cctgccttct
tgtccggaga gcagaagaag gccatcgtcg acctgctctt 3720caagaccaac
aggaaggtga ctgtcaagca gctgaaggag gactacttca agaagatcga
3780gtgcttcgac tccgtcgaga tctctggtgt cgaggacagg ttcaacgcct
cccttgggac 3840ttaccacgat ctgctcaaga ttattaaaga caaggacttc
ctggacaacg aggagaacga 3900ggacatcctt gaggacatcg tgctcaccct
gaccttgttc gaagacaggg aaatgatcga 3960agagaggctc aagacctacg
cccacctctt cgacgacaag gtgatgaaac agctgaagag 4020acgcagatat
accggctggg gaaggctctc ccgcaaattg atcaacggga tcagggacaa
4080gcagtcaggg aagactatac tcgacttcct gaagtccgac ggattcgcca
acaggaactt 4140catgcagctc attcacgacg actccttgac cttcaaggag
gacatccaga aggctcaggt 4200gtctggacag ggtgactcct tgcatgagca
cattgctaac ttggccggct ctcccgctat 4260taagaagggc attttgcaga
ccgtgaaggt cgttgacgag ctcgtgaagg tgatgggacg 4320ccacaagcca
gagaacatcg ttattgagat ggctcgcgag aaccaaacta cccagaaagg
4380gcagaagaat tcccgcgaga ggatgaagcg cattgaggag ggcataaaag
agcttggctc 4440tcagatcctc aaggagcacc ccgtcgagaa cactcagctg
cagaacgaga agctgtacct 4500gtactacctc caaaacggaa gggacatgta
cgtggaccag gagctggaca tcaacaggtt 4560gtccgactac gacgtcgacc
acatcgtgcc tcagtccttc ctgaaggatg actccatcga 4620caataaagtg
ctgacacgct ccgataaaaa tagaggcaag tccgacaacg tcccctccga
4680ggaggtcgtg aagaagatga aaaactactg gagacagctc ttgaacgcca
agctcatcac 4740ccagcgtaag ttcgacaacc tgactaaggc tgagagagga
ggattgtccg agctcgataa 4800ggccggattc atcaagagac agctcgtcga
aacccgccaa attaccaagc acgtggccca 4860aattctggat tcccgcatga
acaccaagta cgatgaaaat gacaagctga tccgcgaggt 4920caaggtgatc
accttgaagt ccaagctggt ctccgacttc cgcaaggact tccagttcta
4980caaggtgagg gagatcaaca actaccacca cgcacacgac gcctacctca
acgctgtcgt 5040tggaaccgcc ctcatcaaaa aatatcctaa gctggagtct
gagttcgtct acggcgacta 5100caaggtgtac gacgtgagga agatgatcgc
taagtctgag caggagatcg gcaaggccac 5160cgccaagtac ttcttctact
ccaacatcat gaacttcttc aagaccgaga tcactctcgc 5220caacggtgag
atcaggaagc gcccactgat cgagaccaac ggtgagactg gagagatcgt
5280gtgggacaaa gggagggatt tcgctactgt gaggaaggtg ctctccatgc
ctcaggtgaa 5340catcgtcaag aagaccgaag ttcagaccgg aggattctcc
aaggagtcca tcctccccaa 5400gagaaactcc gacaagctga tcgctagaaa
gaaagactgg gaccctaaga agtacggagg 5460cttcgattct cctaccgtgg
cctactctgt gctggtcgtg gccaaggtgg agaagggcaa 5520gtccaagaag
ctgaaatccg tcaaggagct cctcgggatt accatcatgg agaggagttc
5580cttcgagaag aaccctatcg acttcctgga ggccaaggga tataaagagg
tgaagaagga 5640cctcatcatc aagctgccca agtactccct cttcgagttg
gagaacggaa ggaagaggat 5700gctggcttct gccggagagt tgcagaaggg
aaatgagctc gcccttccct ccaagtacgt 5760gaacttcctg tacctcgcct
ctcactatga aaagttgaag ggctctcctg aggacaacga 5820gcagaagcag
ctcttcgtgg agcagcacaa gcactacctg gacgaaatta tcgagcagat
5880ctctgagttc tccaagcgcg tgatattggc cgacgccaac ctcgacaagg
tgctgtccgc 5940ctacaacaag cacagggata agcccattcg cgagcaggct
gaaaacatta tccacctgtt 6000taccctcaca aacttgggag cccctgctgc
cttcaagtac ttcgacacca ccattgacag 6060gaagagatac acctccacca
aggaggtgct cgacgcaaca ctcatccacc aatccatcac 6120cggcctctat
gaaacaagga ttgacttgtc ccagctggga ggcgactcta gagccgatcc
6180caagaagaag agaaaggtgt aggttaacct agacttgtcc atcttctgga
ttggccaact 6240taattaatgt atgaaataaa aggatgcaca catagtgaca
tgctaatcac tataatgtgg 6300gcatcaaagt tgtgtgttat gtgtaattac
tagttatctg aataaaagag aaagagatca 6360tccatatttc ttatcctaaa
tgaatgtcac gtgtctttat aattctttga tgaaccagat 6420gcatttcatt
aaccaaatcc atatacatat aaatattaat catatataat taatatcaat
6480tgggttagca aaacaaatct agtctaggtg tgttttgcga attcgatatc
aagcttatcg 6540ataccgtcga gggggggccc ggtaccggcg cgccgttcta
tagtgtcacc taaatcgtat 6600gtgtatgata cataaggtta tgtattaatt
gtagccgcgt tctaacgaca atatgtccat 6660atggtgcact ctcagtacaa
tctgctctga tgccgcatag ttaagccagc cccgacaccc 6720gccaacaccc
gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca
6780agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat
caccgaaacg 6840cgcgagacga aagggcctcg tgatacgcct atttttatag
gttaatgtca tgaccaaaat 6900cccttaacgt gagttttcgt tccactgagc
gtcagacccc gtagaaaaga tcaaaggatc 6960ttcttgagat cctttttttc
tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct 7020accagcggtg
gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg
7080cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt
taggccacca 7140cttcaagaac tctgtagcac cgcctacata cctcgctctg
ctaatcctgt taccagtggc 7200tgctgccagt ggcgataagt cgtgtcttac
cgggttggac tcaagacgat agttaccgga 7260taaggcgcag cggtcgggct
gaacgggggg ttcgtgcaca cagcccagct tggagcgaac 7320gacctacacc
gaactgagat acctacagcg tgagcattga gaaagcgcca cgcttcccga
7380agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag
agcgcacgag 7440ggagcttcca gggggaaacg cctggtatct ttatagtcct
gtcgggtttc gccacctctg 7500acttgagcgt cgatttttgt gatgctcgtc
aggggggcgg agcctatgga aaaacgccag 7560caacgcggcc tttttacggt
tcctggcctt ttgctggcct tttgctcaca tgttctttcc 7620tgcgttatcc
cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc
7680tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg
aagagcgccc 7740aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat
taatgcaggt tgatcagatc 7800tcgatcccgc gaaattaata cgactcacta
tagggagacc acaacggttt ccctctagaa 7860ataattttgt ttaactttaa
gaaggagata tacccatgga aaagcctgaa ctcaccgcga 7920cgtctgtcga
gaagtttctg atcgaaaagt tcgacagcgt ctccgacctg atgcagctct
7980cggagggcga agaatctcgt gctttcagct tcgatgtagg agggcgtgga
tatgtcctgc 8040gggtaaatag ctgcgccgat ggtttctaca aagatcgtta
tgtttatcgg cactttgcat 8100cggccgcgct cccgattccg gaagtgcttg
acattgggga attcagcgag agcctgacct 8160attgcatctc ccgccgtgca
cagggtgtca cgttgcaaga cctgcctgaa accgaactgc 8220ccgctgttct
gcagccggtc gcggaggcta tggatgcgat cgctgcggcc gatcttagcc
8280agacgagcgg gttcggccca ttcggaccgc aaggaatcgg tcaatacact
acatggcgtg 8340atttcatatg cgcgattgct gatccccatg tgtatcactg
gcaaactgtg atggacgaca 8400ccgtcagtgc gtccgtcgcg caggctctcg
atgagctgat gctttgggcc gaggactgcc 8460ccgaagtccg gcacctcgtg
cacgcggatt tcggctccaa caatgtcctg acggacaatg 8520gccgcataac
agcggtcatt gactggagcg aggcgatgtt cggggattcc caatacgagg
8580tcgccaacat cttcttctgg aggccgtggt tggcttgtat ggagcagcag
acgcgctact 8640tcgagcggag gcatccggag cttgcaggat cgccgcggct
ccgggcgtat atgctccgca 8700ttggtcttga ccaactctat cagagcttgg
ttgacggcaa tttcgatgat gcagcttggg 8760cgcagggtcg atgcgacgca
atcgtccgat ccggagccgg gactgtcggg cgtacacaaa 8820tcgcccgcag
aagcgcggcc gtctggaccg atggctgtgt agaagtactc gccgatagtg
8880gaaaccgacg ccccagcact cgtccgaggg caaaggaata gtgaggtaca
gcttggatcg 8940atccggctgc taacaaagcc cgaaaggaag ctgagttggc
tgctgccacc gctgagcaat 9000aactagcata accccttggg gcctctaaac
gggtcttgag gggttttttg ctgaaaggag 9060gaactatatc cggatgatcg
ggcgcgccgg tac 90935459093DNAArtificial sequenceQC881 545ccgggtgtga
tttagtataa agtgaagtaa tggtcaaaag aaaaagtgta aaacgaagta 60cctagtaata
agtaatattg aacaaaataa atggtaaagt gtcagatata taaaataggc
120tttaataaaa ggaagaaaaa aaacaaacaa aaaataggtt gcaatggggc
agagcagagt 180catcatgaag ctagaaaggc taccgataga taaactatag
ttaattaaat acattaaaaa 240atacttggat ctttctctta ccctgtttat
attgagacct gaaacttgag agagatacac 300taatcttgcc ttgttgtttc
attccctaac ttacaggact cagcgcatgt catgtggtct 360cgttccccat
ttaagtccca caccgtctaa acttattaaa ttattaatgt ttataactag
420atgcacaaca acaaagcttg ggcgtcggtg ccgatcatcg ttttagagct
agaaatagca 480agttaaaata aggctagtcc gttatcaact tgaaaaagtg
gcaccgagtc ggtgcttttt 540tttgcggccg caattggatc gggtttactt
attttgtggg tatctatact tttattagat 600ttttaatcag gctcctgatt
tctttttatt tcgattgaat tcctgaactt gtattattca 660gtagatcgaa
taaattataa aaagataaaa tcataaaata atattttatc ctatcaatca
720tattaaagca atgaatatgt aaaattaatc ttatctttat tttaaaaaat
catataggtt 780tagtattttt ttaaaaataa agataggatt agttttacta
ttcactgctt attactttta 840aaaaaatcat aaaggtttag tattttttta
aaataaatat aggaatagtt ttactattca 900ctgctttaat agaaaaatag
tttaaaattt aagatagttt taatcccagc atttgccacg 960tttgaacgtg
agccgaaacg atgtcgttac attatcttaa cctagctgaa acgatgtcgt
1020cataatatcg ccaaatgcca actggactac gtcgaaccca caaatcccac
aaagcgcgtg 1080aaatcaaatc gctcaaacca caaaaaagaa caacgcgttt
gttacacgct caatcccacg 1140cgagtagagc acagtaacct tcaaataagc
gaatggggca taatcagaaa tccgaaataa 1200acctaggggc attatcggaa
atgaaaagta gctcactcaa tataaaaatc taggaaccct 1260agttttcgtt
atcactctgt gctccctcgc tctatttctc agtctctgtg tttgcggctg
1320aggattccga acgagtgacc ttcttcgttt ctcgcaaagg taacagcctc
tgctcttgtc 1380tcttcgattc gatctatgcc tgtctcttat ttacgatgat
gtttcttcgg ttatgttttt 1440ttatttatgc tttatgctgt tgatgttcgg
ttgtttgttt cgctttgttt ttgtggttca 1500gttttttagg attcttttgg
tttttgaatc gattaatcgg aagagatttt cgagttattt 1560ggtgtgttgg
aggtgaatct tttttttgag gtcatagatc tgttgtattt gtgttataaa
1620catgcgactt tgtatgattt tttacgaggt tatgatgttc tggttgtttt
attatgaatc 1680tgttgagaca gaaccatgat ttttgttgat gttcgtttac
actattaaag gtttgtttta 1740acaggattaa aagtttttta agcatgttga
aggagtcttg tagatatgta accgtcgata 1800gtttttttgt gggtttgttc
acatgttatc aagcttaatc ttttactatg tatgcgacca 1860tatctggatc
cagcaaaggc gattttttaa ttccttgtga aacttttgta atatgaagtt
1920gaaattttgt tattggtaaa ctataaatgt gtgaagttgg agtatacctt
taccttctta 1980tttggctttg tgatagttta atttatatgt attttgagtt
ctgacttgta tttctttgaa 2040ttgattctag tttaagtaat ccatggacaa
aaagtactca atagggctcg acatagggac 2100taactccgtt ggatgggccg
tcatcaccga cgagtacaag gtgccctcca agaagttcaa 2160ggtgttggga
aacaccgaca ggcacagcat aaagaagaat ttgatcggtg ccctcctctt
2220cgactccgga gagaccgctg aggctaccag gctcaagagg accgctagaa
ggcgctacac 2280cagaaggaag aacagaatct gctacctgca ggagatcttc
tccaacgaga tggccaaggt 2340ggacgactcc ttcttccacc gccttgagga
atcattcctg gtggaggagg ataaaaagca 2400cgagagacac ccaatcttcg
ggaacatcgt cgacgaggtg gcctaccatg aaaagtaccc 2460taccatctac
cacctgagga agaagctggt cgactctacc gacaaggctg acttgcgctt
2520gatttacctg gctctcgctc acatgataaa gttccgcgga cacttcctca
ttgagggaga 2580cctgaaccca gacaactccg acgtggacaa gctcttcatc
cagctcgttc agacctacaa 2640ccagcttttc gaggagaacc caatcaacgc
cagtggagtt gacgccaagg ctatcctctc 2700tgctcgtctg tcaaagtcca
ggaggcttga gaacttgatt gcccagctgc ctggcgaaaa 2760gaagaacgga
ctgttcggaa acttgatcgc tctctccctg ggattgactc ccaacttcaa
2820gtccaacttc gacctcgccg aggacgctaa gttgcagttg tctaaagaca
cctacgacga 2880tgacctcgac aacttgctgg cccagatagg cgaccaatac
gccgatctct tcctcgccgc 2940taagaacttg tccgacgcaa tcctgctgtc
cgacatcctg agagtcaaca ctgagattac 3000caaagctcct ctgtctgctt
ccatgattaa gcgctacgac gagcaccacc aagatctgac 3060cctgctcaag
gccctggtga gacagcagct gcccgagaag tacaaggaga tctttttcga
3120ccagtccaag aacggctacg ccggatacat tgacggaggc gcctcccagg
aagagttcta 3180caagttcatc aagcccatcc ttgagaagat ggacggtacc
gaggagctgt tggtgaagtt 3240gaacagagag gacctgttga ggaagcagag
aaccttcgac aacggaagca tccctcacca 3300aatccacctg ggagagctcc
acgccatctt gaggaggcag gaggatttct atcccttcct 3360gaaggacaac
cgcgagaaga ttgagaagat cttgaccttc agaattcctt actacgtcgg
3420gccactcgcc agaggaaact ctaggttcgc ctggatgacc cgcaaatctg
aagagaccat 3480tactccctgg aacttcgagg aagtcgtgga caagggcgct
tccgctcagt ctttcatcga 3540gaggatgacc aacttcgata aaaatctgcc
caacgagaag gtgctgccca agcactccct 3600gttgtacgag tatttcacag
tgtacaacga gctcaccaag gtgaagtacg tcacagaggg 3660aatgaggaag
cctgccttct tgtccggaga gcagaagaag gccatcgtcg acctgctctt
3720caagaccaac aggaaggtga ctgtcaagca gctgaaggag gactacttca
agaagatcga 3780gtgcttcgac tccgtcgaga tctctggtgt cgaggacagg
ttcaacgcct cccttgggac 3840ttaccacgat ctgctcaaga ttattaaaga
caaggacttc ctggacaacg aggagaacga 3900ggacatcctt gaggacatcg
tgctcaccct gaccttgttc gaagacaggg aaatgatcga 3960agagaggctc
aagacctacg cccacctctt cgacgacaag gtgatgaaac agctgaagag
4020acgcagatat accggctggg gaaggctctc ccgcaaattg atcaacggga
tcagggacaa 4080gcagtcaggg aagactatac tcgacttcct gaagtccgac
ggattcgcca acaggaactt 4140catgcagctc attcacgacg actccttgac
cttcaaggag gacatccaga aggctcaggt 4200gtctggacag ggtgactcct
tgcatgagca cattgctaac ttggccggct ctcccgctat 4260taagaagggc
attttgcaga ccgtgaaggt cgttgacgag ctcgtgaagg tgatgggacg
4320ccacaagcca gagaacatcg ttattgagat ggctcgcgag aaccaaacta
cccagaaagg 4380gcagaagaat tcccgcgaga ggatgaagcg cattgaggag
ggcataaaag agcttggctc 4440tcagatcctc aaggagcacc ccgtcgagaa
cactcagctg cagaacgaga agctgtacct 4500gtactacctc caaaacggaa
gggacatgta cgtggaccag gagctggaca tcaacaggtt 4560gtccgactac
gacgtcgacc acatcgtgcc tcagtccttc ctgaaggatg actccatcga
4620caataaagtg ctgacacgct ccgataaaaa tagaggcaag tccgacaacg
tcccctccga 4680ggaggtcgtg aagaagatga aaaactactg gagacagctc
ttgaacgcca agctcatcac 4740ccagcgtaag ttcgacaacc tgactaaggc
tgagagagga ggattgtccg agctcgataa 4800ggccggattc atcaagagac
agctcgtcga aacccgccaa attaccaagc acgtggccca 4860aattctggat
tcccgcatga acaccaagta cgatgaaaat gacaagctga tccgcgaggt
4920caaggtgatc accttgaagt ccaagctggt ctccgacttc cgcaaggact
tccagttcta 4980caaggtgagg gagatcaaca actaccacca cgcacacgac
gcctacctca acgctgtcgt 5040tggaaccgcc ctcatcaaaa aatatcctaa
gctggagtct gagttcgtct acggcgacta 5100caaggtgtac gacgtgagga
agatgatcgc taagtctgag caggagatcg gcaaggccac 5160cgccaagtac
ttcttctact ccaacatcat gaacttcttc aagaccgaga tcactctcgc
5220caacggtgag atcaggaagc gcccactgat cgagaccaac ggtgagactg
gagagatcgt 5280gtgggacaaa gggagggatt tcgctactgt gaggaaggtg
ctctccatgc ctcaggtgaa 5340catcgtcaag aagaccgaag ttcagaccgg
aggattctcc aaggagtcca tcctccccaa 5400gagaaactcc gacaagctga
tcgctagaaa gaaagactgg gaccctaaga agtacggagg 5460cttcgattct
cctaccgtgg cctactctgt gctggtcgtg gccaaggtgg agaagggcaa
5520gtccaagaag ctgaaatccg tcaaggagct cctcgggatt accatcatgg
agaggagttc 5580cttcgagaag aaccctatcg acttcctgga ggccaaggga
tataaagagg tgaagaagga 5640cctcatcatc aagctgccca agtactccct
cttcgagttg gagaacggaa ggaagaggat 5700gctggcttct gccggagagt
tgcagaaggg aaatgagctc gcccttccct ccaagtacgt 5760gaacttcctg
tacctcgcct ctcactatga aaagttgaag ggctctcctg aggacaacga
5820gcagaagcag ctcttcgtgg agcagcacaa gcactacctg gacgaaatta
tcgagcagat 5880ctctgagttc tccaagcgcg tgatattggc cgacgccaac
ctcgacaagg tgctgtccgc 5940ctacaacaag cacagggata agcccattcg
cgagcaggct gaaaacatta tccacctgtt 6000taccctcaca aacttgggag
cccctgctgc cttcaagtac ttcgacacca ccattgacag 6060gaagagatac
acctccacca aggaggtgct cgacgcaaca ctcatccacc aatccatcac
6120cggcctctat gaaacaagga ttgacttgtc ccagctggga ggcgactcta
gagccgatcc 6180caagaagaag agaaaggtgt aggttaacct agacttgtcc
atcttctgga ttggccaact 6240taattaatgt atgaaataaa aggatgcaca
catagtgaca tgctaatcac tataatgtgg 6300gcatcaaagt tgtgtgttat
gtgtaattac tagttatctg aataaaagag aaagagatca 6360tccatatttc
ttatcctaaa tgaatgtcac gtgtctttat aattctttga tgaaccagat
6420gcatttcatt aaccaaatcc atatacatat aaatattaat catatataat
taatatcaat 6480tgggttagca aaacaaatct agtctaggtg tgttttgcga
attcgatatc aagcttatcg 6540ataccgtcga gggggggccc ggtaccggcg
cgccgttcta tagtgtcacc taaatcgtat 6600gtgtatgata cataaggtta
tgtattaatt gtagccgcgt tctaacgaca atatgtccat 6660atggtgcact
ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc
6720gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg
cttacagaca 6780agctgtgacc gtctccggga gctgcatgtg tcagaggttt
tcaccgtcat caccgaaacg 6840cgcgagacga aagggcctcg tgatacgcct
atttttatag gttaatgtca tgaccaaaat 6900cccttaacgt gagttttcgt
tccactgagc gtcagacccc gtagaaaaga tcaaaggatc 6960ttcttgagat
cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct
7020accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga
aggtaactgg 7080cttcagcaga gcgcagatac caaatactgt ccttctagtg
tagccgtagt taggccacca 7140cttcaagaac tctgtagcac cgcctacata
cctcgctctg ctaatcctgt taccagtggc 7200tgctgccagt ggcgataagt
cgtgtcttac cgggttggac tcaagacgat agttaccgga 7260taaggcgcag
cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac
7320gacctacacc gaactgagat acctacagcg tgagcattga gaaagcgcca
cgcttcccga 7380agggagaaag gcggacaggt atccggtaag cggcagggtc
ggaacaggag agcgcacgag 7440ggagcttcca gggggaaacg cctggtatct
ttatagtcct gtcgggtttc gccacctctg 7500acttgagcgt cgatttttgt
gatgctcgtc aggggggcgg agcctatgga aaaacgccag 7560caacgcggcc
tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc
7620tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag
ctgataccgc 7680tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc
gaggaagcgg aagagcgccc 7740aatacgcaaa ccgcctctcc ccgcgcgttg
gccgattcat taatgcaggt tgatcagatc 7800tcgatcccgc gaaattaata
cgactcacta tagggagacc acaacggttt ccctctagaa 7860ataattttgt
ttaactttaa gaaggagata tacccatgga aaagcctgaa ctcaccgcga
7920cgtctgtcga gaagtttctg atcgaaaagt tcgacagcgt ctccgacctg
atgcagctct 7980cggagggcga agaatctcgt gctttcagct tcgatgtagg
agggcgtgga tatgtcctgc 8040gggtaaatag ctgcgccgat ggtttctaca
aagatcgtta tgtttatcgg cactttgcat 8100cggccgcgct cccgattccg
gaagtgcttg acattgggga attcagcgag agcctgacct 8160attgcatctc
ccgccgtgca cagggtgtca cgttgcaaga cctgcctgaa accgaactgc
8220ccgctgttct gcagccggtc gcggaggcta tggatgcgat cgctgcggcc
gatcttagcc 8280agacgagcgg gttcggccca ttcggaccgc aaggaatcgg
tcaatacact acatggcgtg 8340atttcatatg cgcgattgct gatccccatg
tgtatcactg gcaaactgtg atggacgaca 8400ccgtcagtgc gtccgtcgcg
caggctctcg atgagctgat gctttgggcc gaggactgcc 8460ccgaagtccg
gcacctcgtg cacgcggatt tcggctccaa caatgtcctg acggacaatg
8520gccgcataac agcggtcatt gactggagcg aggcgatgtt cggggattcc
caatacgagg 8580tcgccaacat cttcttctgg aggccgtggt tggcttgtat
ggagcagcag acgcgctact 8640tcgagcggag gcatccggag cttgcaggat
cgccgcggct ccgggcgtat atgctccgca 8700ttggtcttga ccaactctat
cagagcttgg ttgacggcaa tttcgatgat gcagcttggg 8760cgcagggtcg
atgcgacgca atcgtccgat ccggagccgg gactgtcggg cgtacacaaa
8820tcgcccgcag aagcgcggcc gtctggaccg atggctgtgt agaagtactc
gccgatagtg 8880gaaaccgacg ccccagcact cgtccgaggg caaaggaata
gtgaggtaca gcttggatcg 8940atccggctgc taacaaagcc cgaaaggaag
ctgagttggc tgctgccacc gctgagcaat 9000aactagcata accccttggg
gcctctaaac gggtcttgag gggttttttg ctgaaaggag 9060gaactatatc
cggatgatcg ggcgcgccgg tac 90935461113DNAArtificial sequenceRTW1026A
546agcttggtac cgagctcgga tccactagta tggcggccac cgcttccaga
accacccgat 60tctcttcttc ctcttcacac cccaccttcc ccaaacgcat tactagatcc
accctccctc 120tctctcatca aaccctcacc aaacccaacc acgctctcaa
aatcaaatgt tccatctcca 180aaccccccac ggcggcgccc ttcaccaagg
aagcgccgac cacggagccc ttcgtgtcac 240ggttcgcctc cggcgaacct
cgcaagggcg cggacatcct tgtggaggcg ctggagaggc 300agggcgtgac
gacggtgttc gcgtaccccg gcggtgcgtc gatggagatc caccaggcgc
360tcacgcgctc cgccgccatc cgcaacgtgc tcccgcgcca cgagcagggc
ggcgtcttcg 420ccgccgaagg ctacgcgcgt tcctccggcc tccccggcgt
ctgcattgcc acctccggcc 480ccggcgccac caacctcgtg agcggcctcg
ccgacgcttt aatggacagc gtcccagtcg 540tcgccatcac cggccaggtc
agccgtcgca tgatcggtac cgacgccttc caagaaaccc 600cgatcgtgga
ggtgagcaga tccatcacga agcacaacta cctcatcctc gacgtcgacg
660acatcccccg cgtcgtcgcc gaggctttct tcgtcgccac ctccggccgc
cccggtccgg 720tcctcatcga cattcccaaa gacgttcagc agcaactcgc
cgtgcctaat tgggacgagc 780ccgttaacct ccccggttac ctcgccaggc
tgcccaggcc ccccgccgag gcccaattgg 840aacacattgt cagactcatc
atggaggccc aaaagcccgt tctctacgtc ggcggtggca 900gtttgaattc
cagtgctgaa ttgaggcgct ttgttgaact cactggtatt cccgttgcta
960gcactttaat gggtcttgga acttttccta ttggtgatga atattccctt
cagatgctgg 1020gtatgcatgg tactgtttat gctaactatg ctgttgacaa
tagtgatttg ttgcttgcct 1080ttggggtaag gtttgatgac cgtgttactg gga
111354717DNAArtificialWOL900, Forward_primer 547atcaccggcc aggtcag
1754825DNAArtificialWOL578, Reverse_primer 548acttaccctc cactcctttc
tcctc 2554929DNAArtificialWOL573, Forward_primer 549atggcggcca
ccgcttccag aaccacccg 29550638PRTzea mays 550Met Ala Thr Ala Ala Ala
Ala Ser Thr Ala Leu Thr Gly Ala Thr Thr 1 5 10 15 Ala Ala Pro Lys
Ala Arg Arg Arg Ala His Leu Leu Ala Thr Arg Arg 20 25 30 Ala Leu
Ala Ala Pro Ile Arg Cys Ser Ala Ala Ser Pro Ala Met Pro 35 40 45
Met Ala Pro Pro Ala Thr Pro Leu Arg Pro Trp Gly Pro Thr Glu Pro 50
55 60 Arg Lys Gly Ala Asp Ile Leu Val Glu Ser Leu Glu Arg Cys Gly
Val 65 70 75 80 Arg Asp Val Phe Ala Tyr Pro Gly Gly Ala Ser Met Glu
Ile His Gln 85 90 95 Ala Leu Thr Arg Ser Pro Val Ile Ala Asn His
Leu Phe Arg His Glu 100 105 110 Gln Gly Glu Ala Phe Ala Ala Ser Gly
Tyr Ala Arg Ser Ser Gly Arg 115 120 125 Val Gly Val Cys Ile Ala Thr
Ser Gly Pro Gly Ala Thr Asn Leu Val 130 135 140 Ser Ala Leu Ala Asp
Ala Leu Leu Asp Ser Val Pro Met Val Ala Ile 145 150 155 160 Thr Gly
Gln Val Pro Arg Arg Met Ile Gly Thr Asp Ala Phe Gln Glu 165 170 175
Thr Pro Ile Val Glu Val Thr Arg Ser Ile Thr Lys His Asn Tyr Leu 180
185 190 Val Leu Asp Val Asp Asp Ile Pro Arg Val Val Gln Glu Ala Phe
Phe 195 200 205 Leu Ala Ser Ser Gly Arg Pro Gly Pro Val Leu Val Asp
Ile Pro Lys 210 215 220 Asp Ile Gln Gln Gln Met Ala Val Pro Val Trp
Asp Lys Pro Met Ser 225 230 235 240 Leu Pro Gly Tyr Ile Ala Arg Leu
Pro Lys Pro Pro Ala Thr Glu Leu 245 250 255 Leu Glu Gln Val Leu Arg
Leu Val Gly Glu Ser Arg Arg Pro Val Leu 260 265 270 Tyr Val Gly Gly
Gly Cys Ala Ala Ser Gly Glu Glu Leu Arg Arg Phe 275 280 285 Val Glu
Leu Thr Gly Ile Pro Val Thr Thr Thr Leu Met Gly Leu Gly 290 295 300
Asn Phe Pro Ser Asp Asp Pro Leu Ser Leu Arg Met Leu Gly Met His 305
310 315 320 Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp Lys Ala Asp Leu
Leu Leu 325 330 335 Ala Leu Gly Val Arg Phe Asp Asp Arg Val Thr Gly
Lys Ile Glu Ala 340 345 350 Phe Ala Ser Arg Ala Lys Ile Val His Val
Asp Ile Asp Pro Ala Glu 355 360 365 Ile Gly Lys Asn Lys Gln Pro His
Val Ser Ile Cys Ala Asp Val Lys 370 375 380 Leu Ala Leu Gln Gly Met
Asn Ala Leu Leu Glu Gly Ser Thr Ser Lys 385 390 395 400 Lys Ser Phe
Asp Phe Gly Ser Trp Asn Asp Glu Leu Asp Gln Gln Lys 405 410 415 Arg
Glu Phe Pro Leu Gly Tyr Lys Thr Ser Asn Glu Glu Ile Gln Pro 420 425
430 Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu Thr Lys Gly Glu Ala Ile
435 440 445 Ile Gly Thr Gly Val Gly Gln His Gln Met Trp Ala Ala Gln
Tyr Tyr 450 455 460 Thr Tyr Lys Arg Pro Arg Gln Trp Leu Ser Ser Ala
Gly Leu Gly Ala 465 470 475 480 Met Gly Phe Gly Leu Pro Ala Ala Ala
Gly Ala Ser Val Ala Asn Pro 485 490 495 Gly Val Thr Val Val Asp Ile
Asp Gly Asp Gly Ser Phe Leu Met Asn 500 505 510 Val Gln Glu Leu Ala
Met Ile Arg Ile Glu Asn Leu Pro Val Lys Val 515 520 525 Phe Val Leu
Asn Asn Gln His Leu Gly Met Val Val Gln Trp Glu Asp 530 535 540 Arg
Phe Tyr Lys Ala Asn Arg Ala His Thr Tyr Leu Gly Asn Pro Glu 545 550
555 560 Asn Glu Ser Glu Ile Tyr Pro Asp Phe Val Thr Ile Ala Lys Gly
Phe 565 570 575 Asn Ile Pro Ala Val Arg Val Thr Lys Lys Asn Glu Val
Arg Ala Ala 580 585 590 Ile Lys Lys Met Leu Glu Thr Pro Gly Pro Tyr
Leu Leu Asp Ile Ile 595 600 605 Val Pro His Gln Glu His Val Leu Pro
Met Ile Pro Ser Gly Gly Ala 610 615 620 Phe Lys Asp Met Ile Leu Asp
Gly Asp Gly Arg Thr Val Tyr 625 630 635 55143DNAzea
maysmisc_feature(1)..(43)sense genome sequence Figure 2A and 2B
551gatatatata cctcacacgt acgcgtacgc gtatatatac gtg 4355243DNAzea
maysmisc_feature(1)..(43)complementary genome sequence Figure 2A
and 2B 552cacgtatata tacgcgtacg cgtacgtgtg aggtatatat atc
43553104DNAartificial sequencesequence of Figure 8B 553gtcccttgta
cttgtacgta gttttagagc tagaaatagc aagttaaaat aaggctagtc 60cgttatcaac
ttgaaaaagt ggcaccgagt cggtgctttt tttt 10455470DNAartificial
sequencesense sequence of Figure 10A 554atcaaaattc ggaactgaca
cacgacatga tggaacgtga ctaaggtggg tttttgactt 60tgcatgtcga
7055570DNAartificial sequencecomplementary sequence of Figure 10A
555tcgacatgca aagtcaaaaa cccaccttag tcacgttcca tcatgtcgtg
tgtcagttcc 60gaattttgat 7055670DNAartificial sequencesense sequence
of Figure 10B 556ggcagactcc aattcctctt ttctagaata ccctccgtac
gtacaagtac aagggacttg 60tgagttgtaa 7055770DNAartificial
sequencecomplementary sequence of Figure 10B 557ttacaactca
caagtccctt gtacttgtac gtacggaggg tattctagaa aagaggaatt 60ggagtctgcc
705588PRTZea maysMISC_FEATURE(1)..(8)Maize EPSPS polyubiquitination
site 558Val Glu Asp Ala Lys Glu Glu Val 1 5
5598PRTPetuniaMISC_FEATURE(1)..(8)Petunia EPSPS polyubiquitination
site 559Gly Lys Glu Ser Lys Glu Glu Ile 1 5 5608PRTSolanum
lycopersicumMISC_FEATURE(1)..(8)Tomato EPSPS polyubiquitination
site 560Gly Lys Lys Ser Glu Glu Glu Ile 1 5 5618PRTSorghum
bicolorMISC_FEATURE(1)..(8)Sorghum EPSPS polyubiquitination site
561Glu Lys Asp Ala Lys Glu Glu Val 1 5 5628PRTOryza
sativaMISC_FEATURE(1)..(8)Rice EPSPS polyubiquitination site 562Val
Glu Asp Ser Lys Glu Glu Val 1 5 5638PRTAmaranthus
floridanusMISC_FEATURE(1)..(8)Amaranthus EPSPS polyubiquitination
site 563Gly Lys Asp Gly Lys Glu Glu Ile 1 5 56480DNAartificial
sequencesequence of Figure 34 B 564gctaaagagg aagtgcagct cttcttgggg
aatgctggaa ctgcaatgcg gccattgaca 60gcagctgtta ctgctgctgg
8056580DNAartificial sequencesequence of Figure 34C 565gctagagagg
aagtgcagct cttcttgggg aatgctggaa tcgcaatgcg gtcattgaca 60gcagctgtta
ctgctgctgg 8056637DNAartificial sequencesequence of Figure 35B
566catctcacga tcagatgcac cgcatgtcgc atgccta 3756742DNAartificial
sequencesequence of Figure 35C 567catatctgca cgatcagata tgcaccgcat
gtcgcatatc tg 42
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