U.S. patent application number 16/027629 was filed with the patent office on 2018-12-20 for methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy. This patent application is currently assigned to Cellectis. The applicant listed for this patent is Cellectis. Invention is credited to Roman GALETTO, Agnes GOUBLE, Stephanie GROSSE, Cecile MANNIOUI, Laurent POIROT, Andrew SCHARENBERG, Julianne SMITH.
Application Number | 20180360883 16/027629 |
Document ID | / |
Family ID | 48579464 |
Filed Date | 2018-12-20 |
United States Patent Application | 20180360883 |
Kind Code | A1 |
GALETTO; Roman ; et al. | December 20, 2018 |
Methods for developing engineered T-cells for immunotherapy that are both non-alloreactive and resistant to immunosuppressive drugs. The present invention relates to methods for modifying T-cells by inactivating both genes encoding target for an immunosuppressive agent and T-cell receptor, in particular genes encoding CD52 and TCR. This method involves the use of specific rare cutting endonucleases, in particular TALE-nucleases (TAL effector endonuclease) and polynucleotides encoding such polypeptides, to precisely target a selection of key genes in T-cells, which are available from donors or from culture of primary cells. The invention opens the way to standard and affordable adoptive immunotherapy strategies for treating cancer and viral infections.
Inventors: | GALETTO; Roman; (Paris, FR) ; GOUBLE; Agnes; (Paris, FR) ; GROSSE; Stephanie; (Saint-cyr Sur Morin, FR) ; MANNIOUI; Cecile; (Villiers Sur Marne, FR) ; POIROT; Laurent; (US) ; SCHARENBERG; Andrew; (Seattle, WA) ; SMITH; Julianne; (Le Plessis-Robinson, FR) | ||||||||||
Applicant: |
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Assignee: | Cellectis Paris FR |
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Family ID: | 48579464 | ||||||||||
Appl. No.: | 16/027629 | ||||||||||
Filed: | July 5, 2018 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
13892805 | May 13, 2013 | |||
16027629 | ||||
61651933 | May 25, 2012 | |||
61696612 | Sep 4, 2012 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | A61P 5/38 20180101; C12N 2502/99 20130101; C07K 14/7051 20130101; C07K 14/70517 20130101; C12N 2501/39 20130101; C12N 2501/51 20130101; A61P 35/02 20180101; C12N 2501/599 20130101; C07K 14/70521 20130101; A61K 35/17 20130101; C07K 2319/74 20130101; C12N 2510/00 20130101; A61P 37/06 20180101; C07K 2319/00 20130101; A61P 43/00 20180101; A61P 35/00 20180101; C07K 14/70578 20130101; A61P 31/00 20180101; A61P 37/02 20180101; C07K 2317/14 20130101; A61P 37/04 20180101; C12N 2501/515 20130101; A61P 21/00 20180101; A61K 38/00 20130101; A61K 39/00 20130101; A61P 31/12 20180101; C07K 16/2803 20130101; C07K 16/28 20130101; C07K 2319/03 20130101; C12N 5/0636 20130101; C07K 2317/24 20130101; C07K 2317/622 20130101; C07K 2317/569 20130101 |
International Class: | A61K 35/17 20060101 A61K035/17; C07K 14/705 20060101 C07K014/705; C12N 5/0783 20060101 C12N005/0783; C07K 16/28 20060101 C07K016/28; C07K 14/725 20060101 C07K014/725 |
Sequence CWU 1
1
194149DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideGRex2 1tattcactga tggactccaa agaatcatta
actcctggta gagaagaaa 49249DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotideGRex3T2 2tgcctggtgt
gctctgatga agcttcagga tgtcattatg gagtcttaa 49349DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideGRex3T4 3tgctctgatg aagcttcagg atgtcattat ggagtcttaa
cttgtggaa 49449DNAArtificial SequenceDescription of Artificial
Sequence Synthetic oligonucleotideGRex5T1 4tggtgtcact gttggaggtt
attgaacctg aagtgttata tgcaggata 49549DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideGRex5T2 5tatgatagct ctgttccaga ctcaacttgg aggatcatga
ctacgctca 49649DNAArtificial SequenceDescription of Artificial
Sequence Synthetic oligonucleotideGRex5T3 6ttatatgcag gatatgatag
ctctgttcca gactcaactt ggaggatca 497530PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptideRepeat-GRex2-LPT9-L1 7Leu Thr Pro Glu Gln Val Val Ala
Ile Ala Ser Asn Ile Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu Thr Val
Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 20 25 30 His Gly Leu Thr
Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 35 40 45 Gly Lys
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 50 55 60
Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 65
70 75 80 Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val
Val Ala Ile Ala 100 105 110 Ser His Asp Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu 115 120 125 Pro Val Leu Cys Gln Ala His Gly
Leu Thr Pro Glu Gln Val Val Ala 130 135 140 Ile Ala Ser Asn Ile Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 145 150 155 160 Leu Leu Pro
Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 165 170 175 Val
Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 180 185
190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln
195 200 205 Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala
Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr 225 230 235 240 Pro Gln Gln Val Val Ala Ile Ala Ser
Asn Asn Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val Gln Arg Leu
Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr Pro Glu Gln
Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 275 280 285 Gln Ala Leu
Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 290 295 300 His
Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 305 310
315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu
Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile
Ala Ser Asn 340 345 350 Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly Leu Thr Pro
Gln Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Asn Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390 395 400 Pro Val Leu Cys
Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 405 410 415 Ile Ala
Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 420 425 430
Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 435
440 445 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr
Val 450 455 460 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Gln 465 470 475 480 Gln Val Val Ala Ile Ala Ser Asn Gly Gly
Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Arg Leu Leu Pro Val
Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln Gln Val Val Ala
Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520 525 Leu Glu 530
8530PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideRepeat-GRex2-LPT9-R1 8Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30 His Gly
Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 35 40 45
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 50
55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser
His 65 70 75 80 Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu
Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln
Val Val Ala Ile Ala 100 105 110 Ser Asn Gly Gly Gly Lys Gln Ala Leu
Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val Leu Cys Gln Ala His
Gly Leu Thr Pro Gln Gln Val Val Ala 130 135 140 Ile Ala Ser Asn Gly
Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145 150 155 160 Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 165 170 175
Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 180
185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro
Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln
Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln
Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln Val Val Ala Ile Ala
Ser His Asp Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val Gln Arg
Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr Pro Gln
Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 275 280 285 Gln Ala
Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 290 295 300
His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 305
310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val
Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala
Ile Ala Ser His 340 345 350 Asp Gly Gly Lys Gln Ala Leu Glu Thr Val
Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly Leu Thr
Pro Glu Gln Val Val Ala Ile Ala 370 375 380 Ser His Asp Gly Gly Lys
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390 395 400 Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 405 410 415 Ile
Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 420 425
430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val
435 440 445 Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu
Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly
Leu Thr Pro Gln 465 470 475 480 Gln Val Val Ala Ile Ala Ser Asn Asn
Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Arg Leu Leu Pro
Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln Gln Val Val
Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520 525 Leu Glu 530
9530PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideRepeat-GRex3T2-L1 9Leu Thr Pro Gln Gln Val Val
Ala Ile Ala Ser Asn Asn Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu Thr
Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30 His Gly Leu
Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 35 40 45 Gly
Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 50 55
60 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His
65 70 75 80 Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala Ile Ala 100 105 110 Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu 115 120 125 Pro Val Leu Cys Gln Ala His Gly
Leu Thr Pro Gln Gln Val Val Ala 130 135 140 Ile Ala Ser Asn Asn Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145 150 155 160 Leu Leu Pro
Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 165 170 175 Val
Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 180 185
190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln
195 200 205 Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala
Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr 225 230 235 240 Pro Gln Gln Val Val Ala Ile Ala Ser
Asn Asn Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val Gln Arg Leu
Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr Pro Gln Gln
Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 275 280 285 Gln Ala Leu
Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 290 295 300 His
Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 305 310
315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu
Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile
Ala Ser His 340 345 350 Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly Leu Thr Pro
Gln Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Gly Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390 395 400 Pro Val Leu Cys
Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 405 410 415 Ile Ala
Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 420 425 430
Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 435
440 445 Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr
Val 450 455 460 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Gln 465 470 475 480 Gln Val Val Ala Ile Ala Ser Asn Asn Gly
Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Arg Leu Leu Pro Val
Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln Gln Val Val Ala
Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520 525 Leu Glu 530
10530PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideRepeat-GRex3T2-R1 10Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30 His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 35 40 45
Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys 50
55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser
Asn 65 70 75 80 Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu
Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln
Val Val Ala Ile Ala 100 105 110 Ser Asn Asn Gly Gly Lys Gln Ala Leu
Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val Leu Cys Gln Ala His
Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140 Ile Ala Ser Asn Ile
Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 145 150 155 160 Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 165 170 175
Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 180
185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro
Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln
Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln
Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln Val Val Ala Ile Ala
Ser His Asp Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val Gln Arg
Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr Pro Glu
Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 275 280 285 Gln Ala
Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 290 295 300
His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 305
310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val
Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala
Ile Ala Ser Asn 340 345 350 Gly Gly Gly Lys Gln Ala Leu Glu Thr Val
Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly Leu Thr
Pro Glu Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Ile Gly Gly Lys
Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 385 390 395 400 Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 405 410 415 Ile
Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 420 425
430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val
435 440 445 Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu
Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly
Leu Thr Pro Gln 465 470 475 480 Gln Val Val Ala Ile Ala Ser Asn Asn
Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Arg Leu Leu Pro
Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln Gln Val Val
Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro
Ala 515 520 525 Leu Glu 530 11530PRTArtificial SequenceDescription
of Artificial Sequence Synthetic polypeptideRepeat-GRex3T4-L1 11Leu
Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 1 5 10
15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
20 25 30 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His
Asp Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn 65 70 75 80 Gly Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala 100 105 110 Ser His Asp Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 130 135 140
Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145
150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln
Gln Val 165 170 175 Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala
Leu Glu Thr Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Glu 195 200 205 Gln Val Val Ala Ile Ala Ser Asn
Ile Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Ala Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Gln Gln
Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 245 250 255 Leu
Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265
270 Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys
275 280 285 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys
Gln Ala 290 295 300 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala
Ser Asn Ile Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln
Ala Leu Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro
Glu Gln Val Val Ala Ile Ala Ser Asn 340 345 350 Ile Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 355 360 365 Leu Cys Gln
Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 370 375 380 Ser
Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390
395 400 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val
Ala 405 410 415 Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr
Val Gln Arg 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Gln Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Gly Gly Gly
Lys Gln Ala Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Gln 465 470 475 480 Gln Val Val Ala
Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510
Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515
520 525 Leu Glu 530 12530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat-GRex3T4-R1 12Leu
Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 1 5 10
15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
20 25 30 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His
Asp Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val
Val Ala Ile Ala Ser His 65 70 75 80 Asp Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala 100 105 110 Ser Asn Ile Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 115 120 125 Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140
Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145
150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu
Gln Val 165 170 175 Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala
Leu Glu Thr Val 180 185 190 Gln Ala Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Glu 195 200 205 Gln Val Val Ala Ile Ala Ser Asn
Ile Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Ala Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Gln Gln
Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 245 250 255 Leu
Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265
270 Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys
275 280 285 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys
Gln Ala 290 295 300 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala
Ser Asn Gly Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro
Glu Gln Val Val Ala Ile Ala Ser Asn 340 345 350 Ile Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 355 360 365 Leu Cys Gln
Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 370 375 380 Ser
Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 385 390
395 400 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val
Ala 405 410 415 Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr
Val Gln Arg 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Glu Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Ile Gly Gly
Lys Gln Ala Leu Glu Thr Val 450 455 460 Gln Ala Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala
Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510
Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515
520 525 Leu Glu 530 13530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat-GRex5T1-LPT8-L1
13Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 1
5 10 15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln
Ala 20 25 30 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser
Asn Asn Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu
Leu Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Gln Gln
Val Val Ala Ile Ala Ser Asn 65 70 75 80 Gly Gly Gly Lys Gln Ala Leu
Glu Thr Val Gln Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His
Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 100 105 110 Ser Asn Asn
Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro
Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 130 135
140 Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg
145 150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro
Glu Gln Val 165 170 175 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln
Ala Leu Glu Thr Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln
Ala His Gly Leu Thr Pro Glu 195 200 205 Gln Val Val Ala Ile Ala Ser
Asn Ile Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Ala Leu
Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Glu
Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 245 250 255
Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 260
265 270 Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly
Lys 275 280 285 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala 290 295 300 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile
Ala Ser Asn Asn Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val
Gln Arg Leu Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr
Pro Gln Gln Val Val Ala Ile Ala Ser Asn 340 345 350 Gly Gly Gly Lys
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys
Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 370 375 380
Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385
390 395 400 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala 405 410 415 Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly
Leu Thr Pro Gln Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Asn Gly
Gly Lys Gln Ala Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val
Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr
Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505
510 Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala
515 520 525 Leu Glu 530 14530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat-GRex5T1-LPT8-R1
14Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 1
5 10 15 Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln
Ala 20 25 30 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser
Asn Gly Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu
Leu Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Glu Gln
Val Val Ala Ile Ala Ser His 65 70 75 80 Asp Gly Gly Lys Gln Ala Leu
Glu Thr Val Gln Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His
Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 100 105 110 Ser His Asp
Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro
Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 130 135
140 Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg
145 150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro
Gln Gln Val 165 170 175 Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln
Ala Leu Glu Thr Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln
Ala His Gly Leu Thr Pro Glu 195 200 205 Gln Val Val Ala Ile Ala Ser
His Asp Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu
Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Glu
Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 245 250 255
Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 260
265 270 Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly
Lys 275 280 285 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala 290 295 300 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile
Ala Ser Asn Ile Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val
Gln Ala Leu Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr
Pro Gln Gln Val Val Ala Ile Ala Ser Asn 340 345 350 Gly Gly Gly Lys
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys
Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 370 375 380
Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 385
390 395 400 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val
Val Ala 405 410 415 Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Ala 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly
Leu Thr Pro Glu Gln Val 435 440 445 Val Ala Ile Ala Ser His Asp Gly
Gly Lys Gln Ala Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val
Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr
Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505
510 Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala
515 520 525 Leu Glu 530 15530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat-GRex5T2-L1 15Leu
Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 1 5 10
15 Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala
20 25 30 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn
Gly Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn 65 70 75 80 Asn Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile
Ala 100 105 110 Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln
Ala Leu Leu 115 120 125 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro
Gln Gln Val Val Ala 130 135 140 Ile Ala Ser Asn Gly Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Arg 145 150 155 160 Leu Leu Pro Val Leu Cys
Gln Ala His Gly Leu Thr Pro Glu Gln Val 165 170 175 Val Ala Ile Ala
Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 180 185 190 Gln Ala
Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 195 200 205
Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 210
215 220 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr 225 230 235 240 Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly
Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val Gln Arg Leu Leu Pro Val
Leu Cys Gln Ala His Gly 260 265 270 Leu Thr Pro Gln Gln Val Val Ala
Ile Ala Ser Asn Gly Gly Gly Lys 275 280 285 Gln Ala Leu Glu Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 290 295 300 His Gly Leu Thr
Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 305 310 315 320 Gly
Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 325 330
335 Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn
340 345 350 Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val 355 360 365 Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala Ile Ala 370 375 380 Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu 385 390 395 400 Pro Val Leu Cys Gln Ala His
Gly Leu Thr Pro Gln Gln Val Val Ala 405 410 415 Ile Ala Ser Asn Gly
Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 420 425 430 Leu Leu Pro
Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 435 440 445 Val
Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 450 455
460 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu
465 470 475 480 Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln
Ala Leu Glu 485 490 495 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln
Ala His Gly Leu Thr 500 505 510 Pro Gln Gln Val Val Ala Ile Ala Ser
Asn Gly Gly Gly Arg Pro Ala 515 520 525 Leu Glu 530
16530PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideRepeat-GRex5T2-R1 16Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30 His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 35 40 45
Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys 50
55 60 Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser
Asn 65 70 75 80 Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu
Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln
Val Val Ala Ile Ala 100 105 110 Ser His Asp Gly Gly Lys Gln Ala Leu
Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val Leu Cys Gln Ala His
Gly Leu Thr Pro Gln Gln Val Val Ala 130 135 140 Ile Ala Ser Asn Asn
Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145 150 155 160 Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 165 170 175
Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 180
185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro
Glu 195 200 205 Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln
Ala Leu Glu 210 215 220 Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln
Ala His Gly Leu Thr 225 230 235 240 Pro Gln Gln Val Val Ala Ile Ala
Ser Asn Asn Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val Gln Arg
Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr Pro Gln
Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 275 280 285 Gln Ala
Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 290 295 300
His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 305
310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val
Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala
Ile Ala Ser Asn 340 345 350 Ile Gly Gly Lys Gln Ala Leu Glu Thr Val
Gln Ala Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly Leu Thr
Pro Gln Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Gly Gly Gly Lys
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390 395 400 Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 405 410 415 Ile
Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 420 425
430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val
435 440 445 Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu
Thr Val 450 455 460 Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly
Leu Thr Pro Gln 465 470 475 480 Gln Val Val Ala Ile Ala Ser Asn Gly
Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Arg Leu Leu Pro
Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln Gln Val Val
Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520 525 Leu Glu 530
17530PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideRepeat-GRex5T3-L1 17Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30 His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 35 40 45
Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys 50
55 60 Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser
Asn 65 70 75 80 Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu
Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln
Val Val Ala Ile Ala 100 105 110 Ser Asn Ile Gly Gly Lys Gln Ala Leu
Glu Thr Val Gln Ala Leu Leu 115 120 125 Pro Val Leu Cys Gln Ala His
Gly Leu Thr Pro Gln Gln Val Val Ala 130 135 140 Ile Ala Ser Asn Gly
Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145 150 155 160 Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 165 170 175
Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 180
185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro
Glu 195 200 205 Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln
Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln
Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln Val Val Ala Ile Ala
Ser Asn Ile Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val Gln Ala
Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr Pro Gln
Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 275 280 285 Gln Ala
Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 290 295 300
His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 305
310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val
Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala
Ile Ala Ser Asn 340 345 350 Ile Gly Gly Lys Gln Ala Leu Glu Thr Val
Gln Ala Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly Leu Thr
Pro Gln Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Gly Gly Gly Lys
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390 395 400 Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 405 410 415 Ile
Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 420 425
430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val
435 440 445 Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu
Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly
Leu Thr Pro Gln 465 470 475 480 Gln Val Val Ala Ile Ala Ser Asn Asn
Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Arg Leu Leu Pro
Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln Gln Val Val
Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520 525 Leu Glu 530
18530PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideRepeat-GRex5T3-R1 18Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30 His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 35 40 45
Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys 50
55 60 Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser
Asn 65 70 75 80 Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu
Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln
Val Val Ala Ile Ala 100 105 110 Ser His Asp Gly Gly Lys Gln Ala Leu
Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val Leu Cys Gln Ala His
Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140 Ile Ala Ser His Asp
Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145 150 155 160 Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 165 170 175
Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 180
185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro
Glu 195 200 205 Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln
Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln
Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln Val Val Ala Ile Ala
Ser His Asp Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val Gln Arg
Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr Pro Glu
Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 275 280 285 Gln Ala
Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 290 295 300
His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 305
310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val
Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala
Ile Ala Ser Asn 340 345 350 Asn Gly Gly Lys Gln Ala Leu Glu Thr Val
Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly Leu Thr
Pro Gln Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Gly Gly Gly Lys
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390 395 400 Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 405 410 415 Ile
Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 420 425
430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val
435 440 445 Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu
Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly
Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala Ile Ala Ser Asn Ile
Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Ala Leu Leu Pro
Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln Gln Val Val
Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520 525 Leu Glu 530
192814DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotideGRex2-L TALEN 19atgggcgatc ctaaaaagaa
acgtaaggtc atcgattacc catacgatgt tccagattac 60gctatcgata tcgccgatct
acgcacgctc ggctacagcc agcagcaaca ggagaagatc 120aaaccgaagg
ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt
180acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac
cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca gaggcgacac
acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc acgcgctctg
gaggccttgc tcacggtggc gggagagttg 360agaggtccac cgttacagtt
ggacacaggc caacttctca agattgcaaa acgtggcggc 420gtgaccgcag
tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac
480ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca
ggcgctggag 540acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg
gcttgacccc ccagcaggtg 600gtggccatcg ccagcaatgg cggtggcaag
caggcgctgg agacggtcca gcggctgttg 660ccggtgctgt gccaggccca
cggcttgacc ccccagcagg tggtggccat cgccagcaat 720ggcggtggca
agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc
780cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg
caagcaggcg 840ctggagacgg tccagcggct gttgccggtg ctgtgccagg
cccacggctt gaccccggag 900caggtggtgg ccatcgccag caatattggt
ggcaagcagg cgctggagac ggtgcaggcg 960ctgttgccgg tgctgtgcca
ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc 1020agccacgatg
gcggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc
1080caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaatgg
cggtggcaag 1140caggcgctgg agacggtcca gcggctgttg ccggtgctgt
gccaggccca cggcttgacc 1200ccccagcagg tggtggccat cgccagcaat
aatggtggca agcaggcgct ggagacggtc 1260cagcggctgt tgccggtgct
gtgccaggcc cacggcttga ccccggagca ggtggtggcc 1320atcgccagca
atattggtgg caagcaggcg ctggagacgg tgcaggcgct gttgccggtg
1380ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag
caatggcggt 1440ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 1500ttgacccccc
agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag
1560acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc
ccagcaggtg 1620gtggccatcg ccagcaataa tggtggcaag caggcgctgg
agacggtcca gcggctgttg 1680ccggtgctgt gccaggccca cggcttgacc
ccggagcagg tggtggccat cgccagcaat 1740attggtggca agcaggcgct
ggagacggtg caggcgctgt tgccggtgct gtgccaggcc 1800cacggcttga
ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg
1860ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt
gaccccccag 1920caggtggtgg ccatcgccag caatggcggt ggcaagcagg
cgctggagac ggtccagcgg 1980ctgttgccgg tgctgtgcca ggcccacggc
ttgacccctc agcaggtggt ggccatcgcc 2040agcaatggcg gcggcaggcc
ggcgctggag agcattgttg cccagttatc tcgccctgat 2100ccggcgttgg
ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt
2160cctgcgctgg atgcagtgaa aaagggattg ggggatccta tcagccgttc
ccagctggtg 2220aagtccgagc tggaggagaa gaaatccgag ttgaggcaca
agctgaagta cgtgccccac 2280gagtacatcg agctgatcga gatcgcccgg
aacagcaccc aggaccgtat cctggagatg 2340aaggtgatgg agttcttcat
gaaggtgtac ggctacaggg gcaagcacct gggcggctcc 2400aggaagcccg
acggcgccat ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg
2460gacaccaagg cctactccgg cggctacaac ctgcccatcg gccaggccga
cgaaatgcag 2520aggtacgtgg aggagaacca gaccaggaac aagcacatca
accccaacga gtggtggaag 2580gtgtacccct ccagcgtgac cgagttcaag
ttcctgttcg tgtccggcca cttcaagggc 2640aactacaagg cccagctgac
caggctgaac cacatcacca actgcaacgg cgccgtgctg 2700tccgtggagg
agctcctgat cggcggcgag atgatcaagg ccggcaccct gaccctggag
2760gaggtgagga ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa
2814202832DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotideGRex2-R TALEN 20atgggcgatc ctaaaaagaa
acgtaaggtc atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag
catcgatatc gccgatctac gcacgctcgg ctacagccag 120cagcaacagg
agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca
180ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca
cccggcagcg 240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag
cgttgccaga ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg
tccggcgcac gcgctctgga ggccttgctc 360acggtggcgg gagagttgag
aggtccaccg ttacagttgg acacaggcca acttctcaag 420attgcaaaac
gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg
480acgggtgccc cgctcaactt gaccccccag caggtggtgg ccatcgccag
caatggcggt 540ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 600ttgacccccc agcaggtggt ggccatcgcc
agcaatggcg gtggcaagca ggcgctggag 660acggtccagc ggctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg 720gtggccatcg
ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg
780ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat
cgccagcaat 840ggcggtggca agcaggcgct ggagacggtc cagcggctgt
tgccggtgct gtgccaggcc 900cacggcttga ccccccagca ggtggtggcc
atcgccagca atggcggtgg caagcaggcg 960ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccggag 1020caggtggtgg
ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg
1080ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt
ggccatcgcc 1140agcaatggcg gtggcaagca ggcgctggag acggtccagc
ggctgttgcc ggtgctgtgc 1200caggcccacg gcttgacccc ggagcaggtg
gtggccatcg ccagccacga tggcggcaag 1260caggcgctgg agacggtcca
gcggctgttg ccggtgctgt gccaggccca cggcttgacc 1320ccccagcagg
tggtggccat cgccagcaat ggcggtggca agcaggcgct ggagacggtc
1380cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca
ggtggtggcc 1440atcgccagca atattggtgg caagcaggcg ctggagacgg
tgcaggcgct gttgccggtg 1500ctgtgccagg cccacggctt gaccccggag
caggtggtgg ccatcgccag ccacgatggc 1560ggcaagcagg cgctggagac
ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc 1620ttgaccccgg
agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag
1680acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc
ggagcaggtg 1740gtggccatcg ccagcaatat tggtggcaag caggcgctgg
agacggtgca ggcgctgttg 1800ccggtgctgt gccaggccca cggcttgacc
ccccagcagg tggtggccat cgccagcaat 1860aatggtggca agcaggcgct
ggagacggtc cagcggctgt tgccggtgct gtgccaggcc 1920cacggcttga
ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg
1980ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt
gacccctcag 2040caggtggtgg ccatcgccag caatggcggc ggcaggccgg
cgctggagag cattgttgcc 2100cagttatctc gccctgatcc ggcgttggcc
gcgttgacca acgaccacct cgtcgccttg 2160gcctgcctcg gcgggcgtcc
tgcgctggat gcagtgaaaa agggattggg ggatcctatc 2220agccgttccc
agctggtgaa gtccgagctg gaggagaaga aatccgagtt gaggcacaag
2280ctgaagtacg tgccccacga gtacatcgag ctgatcgaga tcgcccggaa
cagcacccag 2340gaccgtatcc tggagatgaa ggtgatggag ttcttcatga
aggtgtacgg ctacaggggc 2400aagcacctgg gcggctccag gaagcccgac
ggcgccatct acaccgtggg ctcccccatc 2460gactacggcg tgatcgtgga
caccaaggcc tactccggcg gctacaacct gcccatcggc 2520caggccgacg
aaatgcagag gtacgtggag gagaaccaga ccaggaacaa gcacatcaac
2580cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt
cctgttcgtg 2640tccggccact tcaagggcaa ctacaaggcc cagctgacca
ggctgaacca catcaccaac 2700tgcaacggcg ccgtgctgtc cgtggaggag
ctcctgatcg gcggcgagat gatcaaggcc 2760ggcaccctga ccctggagga
ggtgaggagg aagttcaaca acggcgagat caacttcgcg 2820gccgactgat aa
2832212814DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotideGRex3T2-L TALEN 21atgggcgatc ctaaaaagaa
acgtaaggtc atcgattacc catacgatgt tccagattac 60gctatcgata tcgccgatct
acgcacgctc ggctacagcc agcagcaaca ggagaagatc 120aaaccgaagg
ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt
180acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac
cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca gaggcgacac
acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc acgcgctctg
gaggccttgc tcacggtggc gggagagttg 360agaggtccac cgttacagtt
ggacacaggc caacttctca agattgcaaa acgtggcggc 420gtgaccgcag
tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac
480ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca
ggcgctggag 540acggtccagc ggctgttgcc ggtgctgtgc caggcccacg
gcttgacccc ggagcaggtg 600gtggccatcg ccagccacga tggcggcaag
caggcgctgg agacggtcca gcggctgttg 660ccggtgctgt gccaggccca
cggcttgacc ccggagcagg tggtggccat cgccagccac 720gatggcggca
agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc
780cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg
caagcaggcg 840ctggagacgg tccagcggct gttgccggtg ctgtgccagg
cccacggctt gaccccccag 900caggtggtgg ccatcgccag caataatggt
ggcaagcagg cgctggagac ggtccagcgg 960ctgttgccgg tgctgtgcca
ggcccacggc ttgacccccc agcaggtggt ggccatcgcc 1020agcaataatg
gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc
1080caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaatgg
cggtggcaag 1140caggcgctgg agacggtcca gcggctgttg ccggtgctgt
gccaggccca cggcttgacc 1200ccccagcagg tggtggccat cgccagcaat
aatggtggca agcaggcgct ggagacggtc 1260cagcggctgt tgccggtgct
gtgccaggcc cacggcttga ccccccagca ggtggtggcc 1320atcgccagca
atggcggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg
1380ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag
caataatggt 1440ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 1500ttgaccccgg agcaggtggt ggccatcgcc
agccacgatg gcggcaagca ggcgctggag 1560acggtccagc ggctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg 1620gtggccatcg
ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg
1680ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat
cgccagccac 1740gatggcggca agcaggcgct ggagacggtc cagcggctgt
tgccggtgct gtgccaggcc 1800cacggcttga ccccccagca ggtggtggcc
atcgccagca atggcggtgg caagcaggcg 1860ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccccag 1920caggtggtgg
ccatcgccag caataatggt ggcaagcagg cgctggagac ggtccagcgg
1980ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt
ggccatcgcc 2040agcaatggcg gcggcaggcc ggcgctggag agcattgttg
cccagttatc tcgccctgat 2100ccggcgttgg ccgcgttgac caacgaccac
ctcgtcgcct tggcctgcct cggcgggcgt 2160cctgcgctgg atgcagtgaa
aaagggattg ggggatccta tcagccgttc ccagctggtg 2220aagtccgagc
tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac
2280gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat
cctggagatg 2340aaggtgatgg agttcttcat gaaggtgtac ggctacaggg
gcaagcacct gggcggctcc 2400aggaagcccg acggcgccat ctacaccgtg
ggctccccca tcgactacgg cgtgatcgtg 2460gacaccaagg cctactccgg
cggctacaac ctgcccatcg gccaggccga cgaaatgcag 2520aggtacgtgg
aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag
2580gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca
cttcaagggc 2640aactacaagg cccagctgac caggctgaac cacatcacca
actgcaacgg cgccgtgctg 2700tccgtggagg agctcctgat cggcggcgag
atgatcaagg ccggcaccct gaccctggag 2760gaggtgagga ggaagttcaa
caacggcgag atcaacttcg cggccgactg ataa 2814222832DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
polynucleotideGRex3T2-R TALEN 22atgggcgatc ctaaaaagaa acgtaaggtc
atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag catcgatatc
gccgatctac gcacgctcgg ctacagccag 120cagcaacagg agaagatcaa
accgaaggtt cgttcgacag tggcgcagca ccacgaggca 180ctggtcggcc
acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg
240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga
ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac
gcgctctgga ggccttgctc 360acggtggcgg gagagttgag aggtccaccg
ttacagttgg acacaggcca acttctcaag 420attgcaaaac gtggcggcgt
gaccgcagtg gaggcagtgc atgcatggcg caatgcactg 480acgggtgccc
cgctcaactt gaccccccag caggtggtgg ccatcgccag caatggcggt
540ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca
ggcccacggc 600ttgaccccgg agcaggtggt ggccatcgcc agcaatattg
gtggcaagca ggcgctggag 660acggtgcagg cgctgttgcc ggtgctgtgc
caggcccacg gcttgacccc ggagcaggtg 720gtggccatcg ccagcaatat
tggtggcaag caggcgctgg agacggtgca ggcgctgttg 780ccggtgctgt
gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat
840aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct
gtgccaggcc 900cacggcttga ccccggagca ggtggtggcc atcgccagca
atattggtgg caagcaggcg 960ctggagacgg tgcaggcgct gttgccggtg
ctgtgccagg cccacggctt gaccccggag 1020caggtggtgg ccatcgccag
ccacgatggc ggcaagcagg cgctggagac ggtccagcgg 1080ctgttgccgg
tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc
1140agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc
ggtgctgtgc 1200caggcccacg gcttgacccc ggagcaggtg gtggccatcg
ccagccacga tggcggcaag 1260caggcgctgg agacggtcca gcggctgttg
ccggtgctgt gccaggccca cggcttgacc 1320ccggagcagg tggtggccat
cgccagccac gatggcggca agcaggcgct ggagacggtc 1380cagcggctgt
tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc
1440atcgccagca atattggtgg caagcaggcg ctggagacgg tgcaggcgct
gttgccggtg 1500ctgtgccagg cccacggctt gaccccccag caggtggtgg
ccatcgccag caatggcggt 1560ggcaagcagg cgctggagac ggtccagcgg
ctgttgccgg tgctgtgcca ggcccacggc 1620ttgaccccgg agcaggtggt
ggccatcgcc agcaatattg gtggcaagca ggcgctggag 1680acggtgcagg
cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg
1740gtggccatcg ccagcaatat tggtggcaag caggcgctgg agacggtgca
ggcgctgttg 1800ccggtgctgt gccaggccca cggcttgacc ccccagcagg
tggtggccat cgccagcaat 1860ggcggtggca agcaggcgct ggagacggtc
cagcggctgt tgccggtgct gtgccaggcc 1920cacggcttga ccccccagca
ggtggtggcc atcgccagca ataatggtgg caagcaggcg 1980ctggagacgg
tccagcggct gttgccggtg ctgtgccagg cccacggctt gacccctcag
2040caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag
cattgttgcc 2100cagttatctc gccctgatcc ggcgttggcc gcgttgacca
acgaccacct cgtcgccttg 2160gcctgcctcg gcgggcgtcc tgcgctggat
gcagtgaaaa agggattggg ggatcctatc 2220agccgttccc agctggtgaa
gtccgagctg gaggagaaga aatccgagtt gaggcacaag 2280ctgaagtacg
tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag
2340gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg
ctacaggggc 2400aagcacctgg gcggctccag gaagcccgac ggcgccatct
acaccgtggg ctcccccatc 2460gactacggcg tgatcgtgga caccaaggcc
tactccggcg gctacaacct gcccatcggc 2520caggccgacg aaatgcagag
gtacgtggag gagaaccaga ccaggaacaa gcacatcaac 2580cccaacgagt
ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg
2640tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca
catcaccaac 2700tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg
gcggcgagat gatcaaggcc 2760ggcaccctga ccctggagga ggtgaggagg
aagttcaaca acggcgagat caacttcgcg 2820gccgactgat aa
2832232814DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotideGRex3T4-L TALEN 23atgggcgatc ctaaaaagaa
acgtaaggtc atcgattacc catacgatgt tccagattac 60gctatcgata tcgccgatct
acgcacgctc ggctacagcc agcagcaaca ggagaagatc 120aaaccgaagg
ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt
180acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac
cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca gaggcgacac
acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc acgcgctctg
gaggccttgc tcacggtggc gggagagttg 360agaggtccac cgttacagtt
ggacacaggc caacttctca agattgcaaa acgtggcggc 420gtgaccgcag
tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac
480ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca
ggcgctggag 540acggtccagc ggctgttgcc ggtgctgtgc caggcccacg
gcttgacccc ggagcaggtg 600gtggccatcg ccagccacga tggcggcaag
caggcgctgg agacggtcca gcggctgttg 660ccggtgctgt gccaggccca
cggcttgacc ccccagcagg tggtggccat cgccagcaat 720ggcggtggca
agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc
780cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg
caagcaggcg 840ctggagacgg tccagcggct gttgccggtg ctgtgccagg
cccacggctt gaccccccag 900caggtggtgg ccatcgccag caatggcggt
ggcaagcagg cgctggagac ggtccagcgg 960ctgttgccgg tgctgtgcca
ggcccacggc ttgacccccc agcaggtggt ggccatcgcc 1020agcaataatg
gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc
1080caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagcaatat
tggtggcaag 1140caggcgctgg agacggtgca ggcgctgttg ccggtgctgt
gccaggccca cggcttgacc 1200ccccagcagg tggtggccat cgccagcaat
ggcggtggca agcaggcgct ggagacggtc 1260cagcggctgt tgccggtgct
gtgccaggcc cacggcttga ccccccagca ggtggtggcc 1320atcgccagca
ataatggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg
1380ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag
caatattggt 1440ggcaagcagg cgctggagac ggtgcaggcg ctgttgccgg
tgctgtgcca ggcccacggc 1500ttgaccccgg agcaggtggt ggccatcgcc
agcaatattg gtggcaagca ggcgctggag 1560acggtgcagg cgctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg 1620gtggccatcg
ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg
1680ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat
cgccagccac 1740gatggcggca agcaggcgct ggagacggtc cagcggctgt
tgccggtgct gtgccaggcc 1800cacggcttga ccccccagca ggtggtggcc
atcgccagca atggcggtgg caagcaggcg 1860ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccccag 1920caggtggtgg
ccatcgccag caatggcggt ggcaagcagg cgctggagac ggtccagcgg
1980ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt
ggccatcgcc 2040agcaatggcg gcggcaggcc ggcgctggag agcattgttg
cccagttatc tcgccctgat 2100ccggcgttgg ccgcgttgac caacgaccac
ctcgtcgcct tggcctgcct cggcgggcgt 2160cctgcgctgg atgcagtgaa
aaagggattg ggggatccta tcagccgttc ccagctggtg 2220aagtccgagc
tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac
2280gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat
cctggagatg 2340aaggtgatgg agttcttcat gaaggtgtac ggctacaggg
gcaagcacct gggcggctcc 2400aggaagcccg acggcgccat ctacaccgtg
ggctccccca tcgactacgg cgtgatcgtg 2460gacaccaagg cctactccgg
cggctacaac ctgcccatcg gccaggccga cgaaatgcag 2520aggtacgtgg
aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag
2580gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca
cttcaagggc 2640aactacaagg cccagctgac caggctgaac cacatcacca
actgcaacgg cgccgtgctg 2700tccgtggagg agctcctgat cggcggcgag
atgatcaagg ccggcaccct gaccctggag 2760gaggtgagga ggaagttcaa
caacggcgag atcaacttcg cggccgactg ataa 2814242832DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
polynucleotideGRex3T4-R TALEN 24atgggcgatc ctaaaaagaa acgtaaggtc
atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag catcgatatc
gccgatctac gcacgctcgg ctacagccag 120cagcaacagg agaagatcaa
accgaaggtt cgttcgacag tggcgcagca ccacgaggca 180ctggtcggcc
acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg
240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga
ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac
gcgctctgga ggccttgctc 360acggtggcgg gagagttgag aggtccaccg
ttacagttgg acacaggcca acttctcaag 420attgcaaaac gtggcggcgt
gaccgcagtg gaggcagtgc atgcatggcg caatgcactg 480acgggtgccc
cgctcaactt gaccccccag caggtggtgg ccatcgccag caatggcggt
540ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca
ggcccacggc 600ttgaccccgg agcaggtggt ggccatcgcc agccacgatg
gcggcaagca ggcgctggag 660acggtccagc ggctgttgcc ggtgctgtgc
caggcccacg gcttgacccc ggagcaggtg 720gtggccatcg ccagccacga
tggcggcaag caggcgctgg agacggtcca gcggctgttg 780ccggtgctgt
gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagcaat
840attggtggca agcaggcgct ggagacggtg caggcgctgt tgccggtgct
gtgccaggcc 900cacggcttga ccccggagca ggtggtggcc atcgccagcc
acgatggcgg caagcaggcg 960ctggagacgg tccagcggct gttgccggtg
ctgtgccagg cccacggctt gaccccggag 1020caggtggtgg ccatcgccag
caatattggt ggcaagcagg cgctggagac ggtgcaggcg 1080ctgttgccgg
tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc
1140agcaatattg gtggcaagca ggcgctggag acggtgcagg cgctgttgcc
ggtgctgtgc 1200caggcccacg gcttgacccc ccagcaggtg gtggccatcg
ccagcaataa tggtggcaag 1260caggcgctgg agacggtcca gcggctgttg
ccggtgctgt gccaggccca cggcttgacc 1320ccccagcagg tggtggccat
cgccagcaat ggcggtggca agcaggcgct ggagacggtc 1380cagcggctgt
tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc
1440atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct
gttgccggtg 1500ctgtgccagg cccacggctt gaccccggag caggtggtgg
ccatcgccag caatattggt 1560ggcaagcagg cgctggagac ggtgcaggcg
ctgttgccgg tgctgtgcca ggcccacggc 1620ttgaccccgg agcaggtggt
ggccatcgcc agcaatattg gtggcaagca ggcgctggag 1680acggtgcagg
cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg
1740gtggccatcg ccagcaataa tggtggcaag
caggcgctgg agacggtcca gcggctgttg 1800ccggtgctgt gccaggccca
cggcttgacc ccggagcagg tggtggccat cgccagcaat 1860attggtggca
agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc
1920cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg
caagcaggcg 1980ctggagacgg tccagcggct gttgccggtg ctgtgccagg
cccacggctt gacccctcag 2040caggtggtgg ccatcgccag caatggcggc
ggcaggccgg cgctggagag cattgttgcc 2100cagttatctc gccctgatcc
ggcgttggcc gcgttgacca acgaccacct cgtcgccttg 2160gcctgcctcg
gcgggcgtcc tgcgctggat gcagtgaaaa agggattggg ggatcctatc
2220agccgttccc agctggtgaa gtccgagctg gaggagaaga aatccgagtt
gaggcacaag 2280ctgaagtacg tgccccacga gtacatcgag ctgatcgaga
tcgcccggaa cagcacccag 2340gaccgtatcc tggagatgaa ggtgatggag
ttcttcatga aggtgtacgg ctacaggggc 2400aagcacctgg gcggctccag
gaagcccgac ggcgccatct acaccgtggg ctcccccatc 2460gactacggcg
tgatcgtgga caccaaggcc tactccggcg gctacaacct gcccatcggc
2520caggccgacg aaatgcagag gtacgtggag gagaaccaga ccaggaacaa
gcacatcaac 2580cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg
agttcaagtt cctgttcgtg 2640tccggccact tcaagggcaa ctacaaggcc
cagctgacca ggctgaacca catcaccaac 2700tgcaacggcg ccgtgctgtc
cgtggaggag ctcctgatcg gcggcgagat gatcaaggcc 2760ggcaccctga
ccctggagga ggtgaggagg aagttcaaca acggcgagat caacttcgcg
2820gccgactgat aa 2832252814DNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotideGRex5T1-L TALEN
25atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac
60gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc
120aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg
ccacgggttt 180acacacgcgc acatcgttgc gttaagccaa cacccggcag
cgttagggac cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca
gaggcgacac acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc
acgcgctctg gaggccttgc tcacggtggc gggagagttg 360agaggtccac
cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc
420gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc
cccgctcaac 480ttgacccccc agcaggtggt ggccatcgcc agcaataatg
gtggcaagca ggcgctggag 540acggtccagc ggctgttgcc ggtgctgtgc
caggcccacg gcttgacccc ccagcaggtg 600gtggccatcg ccagcaataa
tggtggcaag caggcgctgg agacggtcca gcggctgttg 660ccggtgctgt
gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat
720ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct
gtgccaggcc 780cacggcttga ccccccagca ggtggtggcc atcgccagca
ataatggtgg caagcaggcg 840ctggagacgg tccagcggct gttgccggtg
ctgtgccagg cccacggctt gaccccccag 900caggtggtgg ccatcgccag
caatggcggt ggcaagcagg cgctggagac ggtccagcgg 960ctgttgccgg
tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc
1020agccacgatg gcggcaagca ggcgctggag acggtccagc ggctgttgcc
ggtgctgtgc 1080caggcccacg gcttgacccc ggagcaggtg gtggccatcg
ccagcaatat tggtggcaag 1140caggcgctgg agacggtgca ggcgctgttg
ccggtgctgt gccaggccca cggcttgacc 1200ccggagcagg tggtggccat
cgccagccac gatggcggca agcaggcgct ggagacggtc 1260cagcggctgt
tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc
1320atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct
gttgccggtg 1380ctgtgccagg cccacggctt gaccccccag caggtggtgg
ccatcgccag caataatggt 1440ggcaagcagg cgctggagac ggtccagcgg
ctgttgccgg tgctgtgcca ggcccacggc 1500ttgacccccc agcaggtggt
ggccatcgcc agcaatggcg gtggcaagca ggcgctggag 1560acggtccagc
ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg
1620gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca
gcggctgttg 1680ccggtgctgt gccaggccca cggcttgacc ccccagcagg
tggtggccat cgccagcaat 1740aatggtggca agcaggcgct ggagacggtc
cagcggctgt tgccggtgct gtgccaggcc 1800cacggcttga ccccccagca
ggtggtggcc atcgccagca ataatggtgg caagcaggcg 1860ctggagacgg
tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag
1920caggtggtgg ccatcgccag caatattggt ggcaagcagg cgctggagac
ggtgcaggcg 1980ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc
agcaggtggt ggccatcgcc 2040agcaatggcg gcggcaggcc ggcgctggag
agcattgttg cccagttatc tcgccctgat 2100ccggcgttgg ccgcgttgac
caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt 2160cctgcgctgg
atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg
2220aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta
cgtgccccac 2280gagtacatcg agctgatcga gatcgcccgg aacagcaccc
aggaccgtat cctggagatg 2340aaggtgatgg agttcttcat gaaggtgtac
ggctacaggg gcaagcacct gggcggctcc 2400aggaagcccg acggcgccat
ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg 2460gacaccaagg
cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag
2520aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga
gtggtggaag 2580gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg
tgtccggcca cttcaagggc 2640aactacaagg cccagctgac caggctgaac
cacatcacca actgcaacgg cgccgtgctg 2700tccgtggagg agctcctgat
cggcggcgag atgatcaagg ccggcaccct gaccctggag 2760gaggtgagga
ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa
2814262832DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotideGRex5T1-R TALEN 26atgggcgatc ctaaaaagaa
acgtaaggtc atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag
catcgatatc gccgatctac gcacgctcgg ctacagccag 120cagcaacagg
agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca
180ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca
cccggcagcg 240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag
cgttgccaga ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg
tccggcgcac gcgctctgga ggccttgctc 360acggtggcgg gagagttgag
aggtccaccg ttacagttgg acacaggcca acttctcaag 420attgcaaaac
gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg
480acgggtgccc cgctcaactt gaccccggag caggtggtgg ccatcgccag
caatattggt 540ggcaagcagg cgctggagac ggtgcaggcg ctgttgccgg
tgctgtgcca ggcccacggc 600ttgacccccc agcaggtggt ggccatcgcc
agcaatggcg gtggcaagca ggcgctggag 660acggtccagc ggctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg 720gtggccatcg
ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg
780ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat
cgccagccac 840gatggcggca agcaggcgct ggagacggtc cagcggctgt
tgccggtgct gtgccaggcc 900cacggcttga ccccccagca ggtggtggcc
atcgccagca atggcggtgg caagcaggcg 960ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccccag 1020caggtggtgg
ccatcgccag caataatggt ggcaagcagg cgctggagac ggtccagcgg
1080ctgttgccgg tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt
ggccatcgcc 1140agccacgatg gcggcaagca ggcgctggag acggtccagc
ggctgttgcc ggtgctgtgc 1200caggcccacg gcttgacccc ggagcaggtg
gtggccatcg ccagcaatat tggtggcaag 1260caggcgctgg agacggtgca
ggcgctgttg ccggtgctgt gccaggccca cggcttgacc 1320ccccagcagg
tggtggccat cgccagcaat ggcggtggca agcaggcgct ggagacggtc
1380cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca
ggtggtggcc 1440atcgccagca atattggtgg caagcaggcg ctggagacgg
tgcaggcgct gttgccggtg 1500ctgtgccagg cccacggctt gaccccccag
caggtggtgg ccatcgccag caatggcggt 1560ggcaagcagg cgctggagac
ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc 1620ttgaccccgg
agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag
1680acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc
ggagcaggtg 1740gtggccatcg ccagcaatat tggtggcaag caggcgctgg
agacggtgca ggcgctgttg 1800ccggtgctgt gccaggccca cggcttgacc
ccggagcagg tggtggccat cgccagccac 1860gatggcggca agcaggcgct
ggagacggtc cagcggctgt tgccggtgct gtgccaggcc 1920cacggcttga
ccccggagca ggtggtggcc atcgccagca atattggtgg caagcaggcg
1980ctggagacgg tgcaggcgct gttgccggtg ctgtgccagg cccacggctt
gacccctcag 2040caggtggtgg ccatcgccag caatggcggc ggcaggccgg
cgctggagag cattgttgcc 2100cagttatctc gccctgatcc ggcgttggcc
gcgttgacca acgaccacct cgtcgccttg 2160gcctgcctcg gcgggcgtcc
tgcgctggat gcagtgaaaa agggattggg ggatcctatc 2220agccgttccc
agctggtgaa gtccgagctg gaggagaaga aatccgagtt gaggcacaag
2280ctgaagtacg tgccccacga gtacatcgag ctgatcgaga tcgcccggaa
cagcacccag 2340gaccgtatcc tggagatgaa ggtgatggag ttcttcatga
aggtgtacgg ctacaggggc 2400aagcacctgg gcggctccag gaagcccgac
ggcgccatct acaccgtggg ctcccccatc 2460gactacggcg tgatcgtgga
caccaaggcc tactccggcg gctacaacct gcccatcggc 2520caggccgacg
aaatgcagag gtacgtggag gagaaccaga ccaggaacaa gcacatcaac
2580cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt
cctgttcgtg 2640tccggccact tcaagggcaa ctacaaggcc cagctgacca
ggctgaacca catcaccaac 2700tgcaacggcg ccgtgctgtc cgtggaggag
ctcctgatcg gcggcgagat gatcaaggcc 2760ggcaccctga ccctggagga
ggtgaggagg aagttcaaca acggcgagat caacttcgcg 2820gccgactgat aa
2832272814DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotideGRex5T2-L TALEN 27atgggcgatc ctaaaaagaa
acgtaaggtc atcgattacc catacgatgt tccagattac 60gctatcgata tcgccgatct
acgcacgctc ggctacagcc agcagcaaca ggagaagatc 120aaaccgaagg
ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt
180acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac
cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca gaggcgacac
acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc acgcgctctg
gaggccttgc tcacggtggc gggagagttg 360agaggtccac cgttacagtt
ggacacaggc caacttctca agattgcaaa acgtggcggc 420gtgaccgcag
tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac
480ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca
ggcgctggag 540acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg
gcttgacccc ccagcaggtg 600gtggccatcg ccagcaatgg cggtggcaag
caggcgctgg agacggtcca gcggctgttg 660ccggtgctgt gccaggccca
cggcttgacc ccccagcagg tggtggccat cgccagcaat 720aatggtggca
agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc
780cacggcttga ccccggagca ggtggtggcc atcgccagca atattggtgg
caagcaggcg 840ctggagacgg tgcaggcgct gttgccggtg ctgtgccagg
cccacggctt gaccccccag 900caggtggtgg ccatcgccag caatggcggt
ggcaagcagg cgctggagac ggtccagcgg 960ctgttgccgg tgctgtgcca
ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc 1020agcaatattg
gtggcaagca ggcgctggag acggtgcagg cgctgttgcc ggtgctgtgc
1080caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaataa
tggtggcaag 1140caggcgctgg agacggtcca gcggctgttg ccggtgctgt
gccaggccca cggcttgacc 1200ccggagcagg tggtggccat cgccagccac
gatggcggca agcaggcgct ggagacggtc 1260cagcggctgt tgccggtgct
gtgccaggcc cacggcttga ccccccagca ggtggtggcc 1320atcgccagca
atggcggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg
1380ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag
ccacgatggc 1440ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 1500ttgacccccc agcaggtggt ggccatcgcc
agcaatggcg gtggcaagca ggcgctggag 1560acggtccagc ggctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg 1620gtggccatcg
ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg
1680ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat
cgccagcaat 1740ggcggtggca agcaggcgct ggagacggtc cagcggctgt
tgccggtgct gtgccaggcc 1800cacggcttga ccccccagca ggtggtggcc
atcgccagca atggcggtgg caagcaggcg 1860ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccggag 1920caggtggtgg
ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg
1980ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt
ggccatcgcc 2040agcaatggcg gcggcaggcc ggcgctggag agcattgttg
cccagttatc tcgccctgat 2100ccggcgttgg ccgcgttgac caacgaccac
ctcgtcgcct tggcctgcct cggcgggcgt 2160cctgcgctgg atgcagtgaa
aaagggattg ggggatccta tcagccgttc ccagctggtg 2220aagtccgagc
tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac
2280gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat
cctggagatg 2340aaggtgatgg agttcttcat gaaggtgtac ggctacaggg
gcaagcacct gggcggctcc 2400aggaagcccg acggcgccat ctacaccgtg
ggctccccca tcgactacgg cgtgatcgtg 2460gacaccaagg cctactccgg
cggctacaac ctgcccatcg gccaggccga cgaaatgcag 2520aggtacgtgg
aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag
2580gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca
cttcaagggc 2640aactacaagg cccagctgac caggctgaac cacatcacca
actgcaacgg cgccgtgctg 2700tccgtggagg agctcctgat cggcggcgag
atgatcaagg ccggcaccct gaccctggag 2760gaggtgagga ggaagttcaa
caacggcgag atcaacttcg cggccgactg ataa 2814282832DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
polynucleotideGRex5T2-R TALEN 28atgggcgatc ctaaaaagaa acgtaaggtc
atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag catcgatatc
gccgatctac gcacgctcgg ctacagccag 120cagcaacagg agaagatcaa
accgaaggtt cgttcgacag tggcgcagca ccacgaggca 180ctggtcggcc
acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg
240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga
ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac
gcgctctgga ggccttgctc 360acggtggcgg gagagttgag aggtccaccg
ttacagttgg acacaggcca acttctcaag 420attgcaaaac gtggcggcgt
gaccgcagtg gaggcagtgc atgcatggcg caatgcactg 480acgggtgccc
cgctcaactt gaccccccag caggtggtgg ccatcgccag caataatggt
540ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca
ggcccacggc 600ttgaccccgg agcaggtggt ggccatcgcc agcaatattg
gtggcaagca ggcgctggag 660acggtgcagg cgctgttgcc ggtgctgtgc
caggcccacg gcttgacccc ccagcaggtg 720gtggccatcg ccagcaataa
tggtggcaag caggcgctgg agacggtcca gcggctgttg 780ccggtgctgt
gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac
840gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct
gtgccaggcc 900cacggcttga ccccccagca ggtggtggcc atcgccagca
ataatggtgg caagcaggcg 960ctggagacgg tccagcggct gttgccggtg
ctgtgccagg cccacggctt gaccccccag 1020caggtggtgg ccatcgccag
caatggcggt ggcaagcagg cgctggagac ggtccagcgg 1080ctgttgccgg
tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc
1140agcaatattg gtggcaagca ggcgctggag acggtgcagg cgctgttgcc
ggtgctgtgc 1200caggcccacg gcttgacccc ccagcaggtg gtggccatcg
ccagcaataa tggtggcaag 1260caggcgctgg agacggtcca gcggctgttg
ccggtgctgt gccaggccca cggcttgacc 1320ccccagcagg tggtggccat
cgccagcaat ggcggtggca agcaggcgct ggagacggtc 1380cagcggctgt
tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc
1440atcgccagcc acgatggcgg caagcaggcg ctggagacgg tccagcggct
gttgccggtg 1500ctgtgccagg cccacggctt gaccccggag caggtggtgg
ccatcgccag caatattggt 1560ggcaagcagg cgctggagac ggtgcaggcg
ctgttgccgg tgctgtgcca ggcccacggc 1620ttgacccccc agcaggtggt
ggccatcgcc agcaatggcg gtggcaagca ggcgctggag 1680acggtccagc
ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg
1740gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca
gcggctgttg 1800ccggtgctgt gccaggccca cggcttgacc ccggagcagg
tggtggccat cgccagcaat 1860attggtggca agcaggcgct ggagacggtg
caggcgctgt tgccggtgct gtgccaggcc 1920cacggcttga ccccccagca
ggtggtggcc atcgccagca atggcggtgg caagcaggcg 1980ctggagacgg
tccagcggct gttgccggtg ctgtgccagg cccacggctt gacccctcag
2040caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag
cattgttgcc 2100cagttatctc gccctgatcc ggcgttggcc gcgttgacca
acgaccacct cgtcgccttg 2160gcctgcctcg gcgggcgtcc tgcgctggat
gcagtgaaaa agggattggg ggatcctatc 2220agccgttccc agctggtgaa
gtccgagctg gaggagaaga aatccgagtt gaggcacaag 2280ctgaagtacg
tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag
2340gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg
ctacaggggc 2400aagcacctgg gcggctccag gaagcccgac ggcgccatct
acaccgtggg ctcccccatc 2460gactacggcg tgatcgtgga caccaaggcc
tactccggcg gctacaacct gcccatcggc 2520caggccgacg aaatgcagag
gtacgtggag gagaaccaga ccaggaacaa gcacatcaac 2580cccaacgagt
ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg
2640tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca
catcaccaac 2700tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg
gcggcgagat gatcaaggcc 2760ggcaccctga ccctggagga ggtgaggagg
aagttcaaca acggcgagat caacttcgcg 2820gccgactgat aa
2832292814DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotideGRex5T3-L TALEN 29atgggcgatc ctaaaaagaa
acgtaaggtc atcgattacc catacgatgt tccagattac 60gctatcgata tcgccgatct
acgcacgctc ggctacagcc agcagcaaca ggagaagatc 120aaaccgaagg
ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt
180acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac
cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca gaggcgacac
acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc acgcgctctg
gaggccttgc tcacggtggc gggagagttg 360agaggtccac cgttacagtt
ggacacaggc caacttctca agattgcaaa acgtggcggc 420gtgaccgcag
tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac
480ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca
ggcgctggag 540acggtccagc ggctgttgcc ggtgctgtgc caggcccacg
gcttgacccc ggagcaggtg 600gtggccatcg ccagcaatat tggtggcaag
caggcgctgg agacggtgca ggcgctgttg 660ccggtgctgt gccaggccca
cggcttgacc ccccagcagg tggtggccat cgccagcaat 720ggcggtggca
agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc
780cacggcttga ccccggagca ggtggtggcc atcgccagca atattggtgg
caagcaggcg 840ctggagacgg tgcaggcgct gttgccggtg ctgtgccagg
cccacggctt gaccccccag 900caggtggtgg ccatcgccag caatggcggt
ggcaagcagg cgctggagac ggtccagcgg 960ctgttgccgg tgctgtgcca
ggcccacggc ttgacccccc agcaggtggt ggccatcgcc 1020agcaataatg
gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc
1080caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagccacga
tggcggcaag 1140caggcgctgg agacggtcca gcggctgttg ccggtgctgt
gccaggccca cggcttgacc 1200ccggagcagg tggtggccat cgccagcaat
attggtggca agcaggcgct ggagacggtg 1260caggcgctgt tgccggtgct
gtgccaggcc cacggcttga ccccccagca ggtggtggcc 1320atcgccagca
ataatggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg
1380ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag
caataatggt 1440ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 1500ttgaccccgg agcaggtggt ggccatcgcc
agcaatattg gtggcaagca ggcgctggag 1560acggtgcagg cgctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg 1620gtggccatcg
ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg
1680ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat
cgccagcaat 1740attggtggca agcaggcgct ggagacggtg caggcgctgt
tgccggtgct gtgccaggcc 1800cacggcttga ccccccagca ggtggtggcc
atcgccagca atggcggtgg caagcaggcg 1860ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccccag 1920caggtggtgg
ccatcgccag caataatggt
ggcaagcagg cgctggagac ggtccagcgg 1980ctgttgccgg tgctgtgcca
ggcccacggc ttgacccctc agcaggtggt ggccatcgcc 2040agcaatggcg
gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat
2100ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct
cggcgggcgt 2160cctgcgctgg atgcagtgaa aaagggattg ggggatccta
tcagccgttc ccagctggtg 2220aagtccgagc tggaggagaa gaaatccgag
ttgaggcaca agctgaagta cgtgccccac 2280gagtacatcg agctgatcga
gatcgcccgg aacagcaccc aggaccgtat cctggagatg 2340aaggtgatgg
agttcttcat gaaggtgtac ggctacaggg gcaagcacct gggcggctcc
2400aggaagcccg acggcgccat ctacaccgtg ggctccccca tcgactacgg
cgtgatcgtg 2460gacaccaagg cctactccgg cggctacaac ctgcccatcg
gccaggccga cgaaatgcag 2520aggtacgtgg aggagaacca gaccaggaac
aagcacatca accccaacga gtggtggaag 2580gtgtacccct ccagcgtgac
cgagttcaag ttcctgttcg tgtccggcca cttcaagggc 2640aactacaagg
cccagctgac caggctgaac cacatcacca actgcaacgg cgccgtgctg
2700tccgtggagg agctcctgat cggcggcgag atgatcaagg ccggcaccct
gaccctggag 2760gaggtgagga ggaagttcaa caacggcgag atcaacttcg
cggccgactg ataa 2814302832DNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotideGRex5T3-R TALEN
30atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc
60gagagacagc acatggacag catcgatatc gccgatctac gcacgctcgg ctacagccag
120cagcaacagg agaagatcaa accgaaggtt cgttcgacag tggcgcagca
ccacgaggca 180ctggtcggcc acgggtttac acacgcgcac atcgttgcgt
taagccaaca cccggcagcg 240ttagggaccg tcgctgtcaa gtatcaggac
atgatcgcag cgttgccaga ggcgacacac 300gaagcgatcg ttggcgtcgg
caaacagtgg tccggcgcac gcgctctgga ggccttgctc 360acggtggcgg
gagagttgag aggtccaccg ttacagttgg acacaggcca acttctcaag
420attgcaaaac gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg
caatgcactg 480acgggtgccc cgctcaactt gaccccccag caggtggtgg
ccatcgccag caataatggt 540ggcaagcagg cgctggagac ggtccagcgg
ctgttgccgg tgctgtgcca ggcccacggc 600ttgaccccgg agcaggtggt
ggccatcgcc agcaatattg gtggcaagca ggcgctggag 660acggtgcagg
cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg
720gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca
gcggctgttg 780ccggtgctgt gccaggccca cggcttgacc ccggagcagg
tggtggccat cgccagccac 840gatggcggca agcaggcgct ggagacggtc
cagcggctgt tgccggtgct gtgccaggcc 900cacggcttga ccccggagca
ggtggtggcc atcgccagcc acgatggcgg caagcaggcg 960ctggagacgg
tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag
1020caggtggtgg ccatcgccag caatggcggt ggcaagcagg cgctggagac
ggtccagcgg 1080ctgttgccgg tgctgtgcca ggcccacggc ttgaccccgg
agcaggtggt ggccatcgcc 1140agccacgatg gcggcaagca ggcgctggag
acggtccagc ggctgttgcc ggtgctgtgc 1200caggcccacg gcttgacccc
ggagcaggtg gtggccatcg ccagccacga tggcggcaag 1260caggcgctgg
agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc
1320ccggagcagg tggtggccat cgccagcaat attggtggca agcaggcgct
ggagacggtg 1380caggcgctgt tgccggtgct gtgccaggcc cacggcttga
ccccggagca ggtggtggcc 1440atcgccagca atattggtgg caagcaggcg
ctggagacgg tgcaggcgct gttgccggtg 1500ctgtgccagg cccacggctt
gaccccccag caggtggtgg ccatcgccag caataatggt 1560ggcaagcagg
cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc
1620ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca
ggcgctggag 1680acggtccagc ggctgttgcc ggtgctgtgc caggcccacg
gcttgacccc ccagcaggtg 1740gtggccatcg ccagcaatgg cggtggcaag
caggcgctgg agacggtcca gcggctgttg 1800ccggtgctgt gccaggccca
cggcttgacc ccccagcagg tggtggccat cgccagcaat 1860aatggtggca
agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc
1920cacggcttga ccccggagca ggtggtggcc atcgccagca atattggtgg
caagcaggcg 1980ctggagacgg tgcaggcgct gttgccggtg ctgtgccagg
cccacggctt gacccctcag 2040caggtggtgg ccatcgccag caatggcggc
ggcaggccgg cgctggagag cattgttgcc 2100cagttatctc gccctgatcc
ggcgttggcc gcgttgacca acgaccacct cgtcgccttg 2160gcctgcctcg
gcgggcgtcc tgcgctggat gcagtgaaaa agggattggg ggatcctatc
2220agccgttccc agctggtgaa gtccgagctg gaggagaaga aatccgagtt
gaggcacaag 2280ctgaagtacg tgccccacga gtacatcgag ctgatcgaga
tcgcccggaa cagcacccag 2340gaccgtatcc tggagatgaa ggtgatggag
ttcttcatga aggtgtacgg ctacaggggc 2400aagcacctgg gcggctccag
gaagcccgac ggcgccatct acaccgtggg ctcccccatc 2460gactacggcg
tgatcgtgga caccaaggcc tactccggcg gctacaacct gcccatcggc
2520caggccgacg aaatgcagag gtacgtggag gagaaccaga ccaggaacaa
gcacatcaac 2580cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg
agttcaagtt cctgttcgtg 2640tccggccact tcaagggcaa ctacaaggcc
cagctgacca ggctgaacca catcaccaac 2700tgcaacggcg ccgtgctgtc
cgtggaggag ctcctgatcg gcggcgagat gatcaaggcc 2760ggcaccctga
ccctggagga ggtgaggagg aagttcaaca acggcgagat caacttcgcg
2820gccgactgat aa 28323160DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotideForward composite
primer for GR exon 2, including SEQ ID NO 128, 10N tag, and SEQ ID
NO 129modified_base(31)..(40)a, c, t or g 31ccatctcatc cctgcgtgtc
tccgactcag nnnnnnnnnn ggttcattta acaagctgcc 603260DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideForward composite primer for GR exon 3, including
SEQ ID NO 128, 10N tag, and SEQ ID NO 130modified_base(31)..(40)a,
c, t or g 32ccatctcatc cctgcgtgtc tccgactcag nnnnnnnnnn gcattctgac
tatgaagtga 603369DNAArtificial SequenceDescription of Artificial
Sequence Synthetic oligonucleotideForward composite primer for GR
exon 5, including SEQ ID NO 128, 10N tag, and SEQ ID NO
131modified_base(31)..(40)a, c, t or g 33ccatctcatc cctgcgtgtc
tccgactcag nnnnnnnnnn tcagcaggcc actacaggag 60tctcacaag
693450DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideReverse composite primer for GR exon 2,
including SEQ ID NO 132 and SEQ ID NO 133 34cctatcccct gtgtgccttg
gcagtctcag agccagtgag ggtgaagacg 503550DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideReverse composite primer for GR exon 3, including
SEQ ID NO 132 and SEQ ID NO 134 35cctatcccct gtgtgccttg gcagtctcag
gggctttgca tataatggaa 503659DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotideReverse composite
primer for GR exon 5, including SEQ ID NO 132 and SEQ ID NO 135
36cctatcccct gtgtgccttg gcagtctcag ctgactctcc ccttcatagt ccccagaac
593749DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideTRAC_T01 37ttgtcccaca gatatccaga
accctgaccc tgccgtgtac cagctgaga 493849DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideTRBC_T01 38tgtgtttgag ccatcagaag cagagatctc
ccacacccaa aaggccaca 493950DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotideTRBC_T02 39ttcccacccg
aggtcgctgt gtttgagcca tcagaagcag agatctccca 504049DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideCD52_T02 40ttcctcctac tcaccatcag cctcctggtt
atggtacagg taagagcaa 4941530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat TRAC_T01-L 41Leu
Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 1 5 10
15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
20 25 30 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn
Asn Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn 65 70 75 80 Gly Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala 100 105 110 Ser His Asp Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140
Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145
150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu
Gln Val 165 170 175 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala
Leu Glu Thr Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Glu 195 200 205 Gln Val Val Ala Ile Ala Ser Asn
Ile Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Ala Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln
Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 245 250 255 Leu
Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265
270 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys
275 280 285 Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys
Gln Ala 290 295 300 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala
Ser Asn Asn Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro
Glu Gln Val Val Ala Ile Ala Ser Asn 340 345 350 Ile Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 355 360 365 Leu Cys Gln
Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 370 375 380 Ser
Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390
395 400 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val
Ala 405 410 415 Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr
Val Gln Ala 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Gln Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Gly Gly Gly
Lys Gln Ala Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala
Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510
Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515
520 525 Leu Glu 530 42530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat TRAC_T01-R 42Leu
Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 1 5 10
15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
20 25 30 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn
Gly Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val
Val Ala Ile Ala Ser His 65 70 75 80 Asp Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala 100 105 110 Ser Asn Ile Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 115 120 125 Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 130 135 140
Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145
150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu
Gln Val 165 170 175 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala
Leu Glu Thr Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn
Gly Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Gln Gln
Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 245 250 255 Leu
Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265
270 Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys
275 280 285 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys
Gln Ala 290 295 300 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala
Ser Asn Gly Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro
Glu Gln Val Val Ala Ile Ala Ser Asn 340 345 350 Ile Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 355 360 365 Leu Cys Gln
Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 370 375 380 Ser
His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390
395 400 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val
Ala 405 410 415 Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr
Val Gln Ala 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Glu Gln Val 435 440 445 Val Ala Ile Ala Ser His Asp Gly Gly
Lys Gln Ala Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Gln 465 470 475 480 Gln Val Val Ala
Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510
Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515
520 525 Leu Glu 530 43530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat TRBC_T01-L 43Leu
Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 1 5 10
15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
20 25 30 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn
Gly Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn 65 70 75 80 Asn Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly
Leu Thr Pro Gln Gln Val Val Ala Ile Ala 100 105 110 Ser Asn Gly Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 130 135 140
Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145
150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln
Gln Val 165 170 175 Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala
Leu Glu Thr Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn
Asn Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln
Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 245 250 255 Leu
Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265
270 Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys
275 280
285 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
290 295 300 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His
Asp Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu
Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Glu Gln
Val Val Ala Ile Ala Ser His 340 345 350 Asp Gly Gly Lys Gln Ala Leu
Glu Thr Val Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His
Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Ile
Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 385 390 395 400
Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 405
410 415 Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro
Glu Gln Val 435 440 445 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln
Ala Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu Cys Gln
Ala His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala Ile Ala
Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Ala
Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln
Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520 525
Leu Glu 530 44530PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideRepeat TRBC_T01-R 44Leu Thr Pro Gln
Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 1 5 10 15 Gln Ala
Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30
His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 35
40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu
Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile
Ala Ser Asn 65 70 75 80 Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro
Gln Gln Val Val Ala Ile Ala 100 105 110 Ser Asn Asn Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val Leu Cys Gln
Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140 Ile Ala Ser
His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145 150 155 160
Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 165
170 175 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr
Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly
Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Gln Gln Val Val Ala
Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr
Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 275 280 285
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 290
295 300 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly
Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn 340 345 350 Asn Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly
Leu Thr Pro Gln Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Asn Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390 395 400 Pro
Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 405 410
415 Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg
420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln
Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala
Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Gln 465 470 475 480 Gln Val Val Ala Ile Ala Ser
Asn Asn Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Arg Leu
Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln Gln
Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520 525 Leu
Glu 530 45530PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideRepeat TRBC_T02-L 45Leu Thr Pro Glu
Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 1 5 10 15 Gln Ala
Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30
His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 35
40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu
Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile
Ala Ser His 65 70 75 80 Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro
Glu Gln Val Val Ala Ile Ala 100 105 110 Ser Asn Ile Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Ala Leu Leu 115 120 125 Pro Val Leu Cys Gln
Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140 Ile Ala Ser
His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145 150 155 160
Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 165
170 175 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr
Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Glu 195 200 205 Gln Val Val Ala Ile Ala Ser His Asp Gly Gly
Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Gln Gln Val Val Ala
Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr
Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 275 280 285
Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 290
295 300 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn
Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn 340 345 350 Asn Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly
Leu Thr Pro Gln Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Gly Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390 395 400 Pro
Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 405 410
415 Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg
420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln
Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala
Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala Ile Ala Ser
His Asp Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Arg Leu
Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln Gln
Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520 525 Leu
Glu 530 46530PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideRepeat TRBC_T02-R 46Leu Thr Pro Gln
Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 1 5 10 15 Gln Ala
Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30
His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 35
40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu
Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile
Ala Ser Asn 65 70 75 80 Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro
Glu Gln Val Val Ala Ile Ala 100 105 110 Ser Asn Ile Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Ala Leu Leu 115 120 125 Pro Val Leu Cys Gln
Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 130 135 140 Ile Ala Ser
Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145 150 155 160
Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 165
170 175 Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr
Val 180 185 190 Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly
Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln Val Val Ala
Ile Ala Ser His Asp Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr
Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 275 280 285
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 290
295 300 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp
Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn 340 345 350 Gly Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly
Leu Thr Pro Gln Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Asn Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390 395 400 Pro
Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 405 410
415 Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg
420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln
Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala
Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Gln 465 470 475 480 Gln Val Val Ala Ile Ala Ser
Asn Gly Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Arg Leu
Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln Gln
Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520 525 Leu
Glu 530 47530PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideRepeat CD52_T02-L 47Leu Thr Pro Gln
Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 1 5 10 15 Gln Ala
Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30
His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 35
40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu
Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile
Ala Ser His 65 70 75 80 Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro
Gln Gln Val Val Ala Ile Ala 100 105 110 Ser Asn Gly Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val Leu Cys Gln
Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140 Ile Ala Ser
His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145 150 155 160
Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 165
170 175 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr
Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly
Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln Val Val Ala
Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val
Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr
Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 275 280 285
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 290
295 300 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly
Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Glu Gln Val
Val Ala Ile Ala Ser His 340 345 350 Asp Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Ile Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 385 390 395 400 Pro
Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 405
410
415 Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg
420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu
Gln Val 435 440 445 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala
Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala Ile Ala Ser
Asn Ile Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Ala Leu
Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln Gln
Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520 525 Leu
Glu 530 48530PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideRepeat CD52_T02-R 48Leu Thr Pro Gln
Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 1 5 10 15 Gln Ala
Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30
His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 35
40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu
Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile
Ala Ser His 65 70 75 80 Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro
Gln Gln Val Val Ala Ile Ala 100 105 110 Ser Asn Gly Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val Leu Cys Gln
Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140 Ile Ala Ser
His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145 150 155 160
Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 165
170 175 Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr
Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly
Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln Val Val Ala
Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val
Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr
Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 275 280 285
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 290
295 300 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp
Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn 340 345 350 Gly Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly
Leu Thr Pro Gln Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Asn Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390 395 400 Pro
Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 405 410
415 Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg
420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu
Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala
Leu Glu Thr Val 450 455 460 Gln Ala Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala Ile Ala Ser
His Asp Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Arg Leu
Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln Gln
Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520 525 Leu
Glu 530 492814DNAArtificial SequenceDescription of Artificial
Sequence Synthetic polynucleotideTRAC_T01-L TALEN 49atgggcgatc
ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac 60gctatcgata
tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc
120aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg
ccacgggttt 180acacacgcgc acatcgttgc gttaagccaa cacccggcag
cgttagggac cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca
gaggcgacac acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc
acgcgctctg gaggccttgc tcacggtggc gggagagttg 360agaggtccac
cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc
420gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc
cccgctcaac 480ttgacccccc agcaggtggt ggccatcgcc agcaatggcg
gtggcaagca ggcgctggag 540acggtccagc ggctgttgcc ggtgctgtgc
caggcccacg gcttgacccc ccagcaggtg 600gtggccatcg ccagcaataa
tggtggcaag caggcgctgg agacggtcca gcggctgttg 660ccggtgctgt
gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat
720ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct
gtgccaggcc 780cacggcttga ccccggagca ggtggtggcc atcgccagcc
acgatggcgg caagcaggcg 840ctggagacgg tccagcggct gttgccggtg
ctgtgccagg cccacggctt gaccccggag 900caggtggtgg ccatcgccag
ccacgatggc ggcaagcagg cgctggagac ggtccagcgg 960ctgttgccgg
tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc
1020agccacgatg gcggcaagca ggcgctggag acggtccagc ggctgttgcc
ggtgctgtgc 1080caggcccacg gcttgacccc ggagcaggtg gtggccatcg
ccagcaatat tggtggcaag 1140caggcgctgg agacggtgca ggcgctgttg
ccggtgctgt gccaggccca cggcttgacc 1200ccggagcagg tggtggccat
cgccagccac gatggcggca agcaggcgct ggagacggtc 1260cagcggctgt
tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc
1320atcgccagca atattggtgg caagcaggcg ctggagacgg tgcaggcgct
gttgccggtg 1380ctgtgccagg cccacggctt gaccccccag caggtggtgg
ccatcgccag caataatggt 1440ggcaagcagg cgctggagac ggtccagcgg
ctgttgccgg tgctgtgcca ggcccacggc 1500ttgaccccgg agcaggtggt
ggccatcgcc agcaatattg gtggcaagca ggcgctggag 1560acggtgcagg
cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg
1620gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca
gcggctgttg 1680ccggtgctgt gccaggccca cggcttgacc ccggagcagg
tggtggccat cgccagcaat 1740attggtggca agcaggcgct ggagacggtg
caggcgctgt tgccggtgct gtgccaggcc 1800cacggcttga ccccccagca
ggtggtggcc atcgccagca atggcggtgg caagcaggcg 1860ctggagacgg
tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag
1920caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac
ggtccagcgg 1980ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc
agcaggtggt ggccatcgcc 2040agcaatggcg gcggcaggcc ggcgctggag
agcattgttg cccagttatc tcgccctgat 2100ccggcgttgg ccgcgttgac
caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt 2160cctgcgctgg
atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg
2220aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta
cgtgccccac 2280gagtacatcg agctgatcga gatcgcccgg aacagcaccc
aggaccgtat cctggagatg 2340aaggtgatgg agttcttcat gaaggtgtac
ggctacaggg gcaagcacct gggcggctcc 2400aggaagcccg acggcgccat
ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg 2460gacaccaagg
cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag
2520aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga
gtggtggaag 2580gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg
tgtccggcca cttcaagggc 2640aactacaagg cccagctgac caggctgaac
cacatcacca actgcaacgg cgccgtgctg 2700tccgtggagg agctcctgat
cggcggcgag atgatcaagg ccggcaccct gaccctggag 2760gaggtgagga
ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa
2814502832DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotideTRAC_T01-R TALEN 50atgggcgatc ctaaaaagaa
acgtaaggtc atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag
catcgatatc gccgatctac gcacgctcgg ctacagccag 120cagcaacagg
agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca
180ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca
cccggcagcg 240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag
cgttgccaga ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg
tccggcgcac gcgctctgga ggccttgctc 360acggtggcgg gagagttgag
aggtccaccg ttacagttgg acacaggcca acttctcaag 420attgcaaaac
gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg
480acgggtgccc cgctcaactt gaccccggag caggtggtgg ccatcgccag
ccacgatggc 540ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 600ttgacccccc agcaggtggt ggccatcgcc
agcaatggcg gtggcaagca ggcgctggag 660acggtccagc ggctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg 720gtggccatcg
ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg
780ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat
cgccagcaat 840attggtggca agcaggcgct ggagacggtg caggcgctgt
tgccggtgct gtgccaggcc 900cacggcttga ccccccagca ggtggtggcc
atcgccagca ataatggtgg caagcaggcg 960ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccggag 1020caggtggtgg
ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg
1080ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt
ggccatcgcc 1140agcaatggcg gtggcaagca ggcgctggag acggtccagc
ggctgttgcc ggtgctgtgc 1200caggcccacg gcttgacccc ccagcaggtg
gtggccatcg ccagcaataa tggtggcaag 1260caggcgctgg agacggtcca
gcggctgttg ccggtgctgt gccaggccca cggcttgacc 1320ccccagcagg
tggtggccat cgccagcaat aatggtggca agcaggcgct ggagacggtc
1380cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca
ggtggtggcc 1440atcgccagca atggcggtgg caagcaggcg ctggagacgg
tccagcggct gttgccggtg 1500ctgtgccagg cccacggctt gaccccggag
caggtggtgg ccatcgccag caatattggt 1560ggcaagcagg cgctggagac
ggtgcaggcg ctgttgccgg tgctgtgcca ggcccacggc 1620ttgaccccgg
agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag
1680acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc
ggagcaggtg 1740gtggccatcg ccagcaatat tggtggcaag caggcgctgg
agacggtgca ggcgctgttg 1800ccggtgctgt gccaggccca cggcttgacc
ccggagcagg tggtggccat cgccagccac 1860gatggcggca agcaggcgct
ggagacggtc cagcggctgt tgccggtgct gtgccaggcc 1920cacggcttga
ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg
1980ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt
gacccctcag 2040caggtggtgg ccatcgccag caatggcggc ggcaggccgg
cgctggagag cattgttgcc 2100cagttatctc gccctgatcc ggcgttggcc
gcgttgacca acgaccacct cgtcgccttg 2160gcctgcctcg gcgggcgtcc
tgcgctggat gcagtgaaaa agggattggg ggatcctatc 2220agccgttccc
agctggtgaa gtccgagctg gaggagaaga aatccgagtt gaggcacaag
2280ctgaagtacg tgccccacga gtacatcgag ctgatcgaga tcgcccggaa
cagcacccag 2340gaccgtatcc tggagatgaa ggtgatggag ttcttcatga
aggtgtacgg ctacaggggc 2400aagcacctgg gcggctccag gaagcccgac
ggcgccatct acaccgtggg ctcccccatc 2460gactacggcg tgatcgtgga
caccaaggcc tactccggcg gctacaacct gcccatcggc 2520caggccgacg
aaatgcagag gtacgtggag gagaaccaga ccaggaacaa gcacatcaac
2580cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt
cctgttcgtg 2640tccggccact tcaagggcaa ctacaaggcc cagctgacca
ggctgaacca catcaccaac 2700tgcaacggcg ccgtgctgtc cgtggaggag
ctcctgatcg gcggcgagat gatcaaggcc 2760ggcaccctga ccctggagga
ggtgaggagg aagttcaaca acggcgagat caacttcgcg 2820gccgactgat aa
2832512814DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotideTRBC_T01-L TALEN 51atgggcgatc ctaaaaagaa
acgtaaggtc atcgattacc catacgatgt tccagattac 60gctatcgata tcgccgatct
acgcacgctc ggctacagcc agcagcaaca ggagaagatc 120aaaccgaagg
ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt
180acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac
cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca gaggcgacac
acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc acgcgctctg
gaggccttgc tcacggtggc gggagagttg 360agaggtccac cgttacagtt
ggacacaggc caacttctca agattgcaaa acgtggcggc 420gtgaccgcag
tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac
480ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca
ggcgctggag 540acggtccagc ggctgttgcc ggtgctgtgc caggcccacg
gcttgacccc ccagcaggtg 600gtggccatcg ccagcaatgg cggtggcaag
caggcgctgg agacggtcca gcggctgttg 660ccggtgctgt gccaggccca
cggcttgacc ccccagcagg tggtggccat cgccagcaat 720aatggtggca
agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc
780cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg
caagcaggcg 840ctggagacgg tccagcggct gttgccggtg ctgtgccagg
cccacggctt gaccccccag 900caggtggtgg ccatcgccag caatggcggt
ggcaagcagg cgctggagac ggtccagcgg 960ctgttgccgg tgctgtgcca
ggcccacggc ttgacccccc agcaggtggt ggccatcgcc 1020agcaatggcg
gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc
1080caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaataa
tggtggcaag 1140caggcgctgg agacggtcca gcggctgttg ccggtgctgt
gccaggccca cggcttgacc 1200ccggagcagg tggtggccat cgccagcaat
attggtggca agcaggcgct ggagacggtg 1260caggcgctgt tgccggtgct
gtgccaggcc cacggcttga ccccccagca ggtggtggcc 1320atcgccagca
ataatggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg
1380ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag
ccacgatggc 1440ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 1500ttgaccccgg agcaggtggt ggccatcgcc
agccacgatg gcggcaagca ggcgctggag 1560acggtccagc ggctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg 1620gtggccatcg
ccagcaatat tggtggcaag caggcgctgg agacggtgca ggcgctgttg
1680ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat
cgccagcaat 1740ggcggtggca agcaggcgct ggagacggtc cagcggctgt
tgccggtgct gtgccaggcc 1800cacggcttga ccccggagca ggtggtggcc
atcgccagcc acgatggcgg caagcaggcg 1860ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccggag 1920caggtggtgg
ccatcgccag caatattggt ggcaagcagg cgctggagac ggtgcaggcg
1980ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt
ggccatcgcc 2040agcaatggcg gcggcaggcc ggcgctggag agcattgttg
cccagttatc tcgccctgat 2100ccggcgttgg ccgcgttgac caacgaccac
ctcgtcgcct tggcctgcct cggcgggcgt 2160cctgcgctgg atgcagtgaa
aaagggattg ggggatccta tcagccgttc ccagctggtg 2220aagtccgagc
tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac
2280gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat
cctggagatg 2340aaggtgatgg agttcttcat gaaggtgtac ggctacaggg
gcaagcacct gggcggctcc 2400aggaagcccg acggcgccat ctacaccgtg
ggctccccca tcgactacgg cgtgatcgtg 2460gacaccaagg cctactccgg
cggctacaac ctgcccatcg gccaggccga cgaaatgcag 2520aggtacgtgg
aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag
2580gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca
cttcaagggc 2640aactacaagg cccagctgac caggctgaac cacatcacca
actgcaacgg cgccgtgctg 2700tccgtggagg agctcctgat cggcggcgag
atgatcaagg ccggcaccct gaccctggag 2760gaggtgagga ggaagttcaa
caacggcgag atcaacttcg cggccgactg ataa 2814522832DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
polynucleotideTRBC_T01-R TALEN 52atgggcgatc ctaaaaagaa acgtaaggtc
atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag catcgatatc
gccgatctac gcacgctcgg ctacagccag 120cagcaacagg agaagatcaa
accgaaggtt cgttcgacag tggcgcagca ccacgaggca 180ctggtcggcc
acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg
240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga
ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac
gcgctctgga ggccttgctc 360acggtggcgg gagagttgag aggtccaccg
ttacagttgg acacaggcca acttctcaag 420attgcaaaac gtggcggcgt
gaccgcagtg gaggcagtgc atgcatggcg caatgcactg 480acgggtgccc
cgctcaactt gaccccccag caggtggtgg ccatcgccag caataatggt
540ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca
ggcccacggc 600ttgacccccc agcaggtggt ggccatcgcc agcaatggcg
gtggcaagca ggcgctggag 660acggtccagc ggctgttgcc ggtgctgtgc
caggcccacg gcttgacccc ccagcaggtg 720gtggccatcg ccagcaataa
tggtggcaag caggcgctgg agacggtcca gcggctgttg 780ccggtgctgt
gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat
840aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct
gtgccaggcc 900cacggcttga ccccggagca ggtggtggcc atcgccagcc
acgatggcgg caagcaggcg 960ctggagacgg tccagcggct gttgccggtg
ctgtgccagg cccacggctt gaccccggag 1020caggtggtgg ccatcgccag
ccacgatggc ggcaagcagg cgctggagac ggtccagcgg 1080ctgttgccgg
tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc
1140agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc
ggtgctgtgc 1200caggcccacg gcttgacccc ccagcaggtg gtggccatcg
ccagcaatgg cggtggcaag 1260caggcgctgg agacggtcca gcggctgttg
ccggtgctgt gccaggccca cggcttgacc 1320ccccagcagg tggtggccat
cgccagcaat ggcggtggca agcaggcgct ggagacggtc 1380cagcggctgt
tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc
1440atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct
gttgccggtg 1500ctgtgccagg cccacggctt gaccccccag caggtggtgg
ccatcgccag caataatggt 1560ggcaagcagg cgctggagac ggtccagcgg
ctgttgccgg tgctgtgcca ggcccacggc 1620ttgacccccc agcaggtggt
ggccatcgcc agcaataatg gtggcaagca ggcgctggag 1680acggtccagc
ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg
1740gtggccatcg ccagcaataa tggtggcaag
caggcgctgg agacggtcca gcggctgttg 1800ccggtgctgt gccaggccca
cggcttgacc ccccagcagg tggtggccat cgccagcaat 1860ggcggtggca
agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc
1920cacggcttga ccccccagca ggtggtggcc atcgccagca ataatggtgg
caagcaggcg 1980ctggagacgg tccagcggct gttgccggtg ctgtgccagg
cccacggctt gacccctcag 2040caggtggtgg ccatcgccag caatggcggc
ggcaggccgg cgctggagag cattgttgcc 2100cagttatctc gccctgatcc
ggcgttggcc gcgttgacca acgaccacct cgtcgccttg 2160gcctgcctcg
gcgggcgtcc tgcgctggat gcagtgaaaa agggattggg ggatcctatc
2220agccgttccc agctggtgaa gtccgagctg gaggagaaga aatccgagtt
gaggcacaag 2280ctgaagtacg tgccccacga gtacatcgag ctgatcgaga
tcgcccggaa cagcacccag 2340gaccgtatcc tggagatgaa ggtgatggag
ttcttcatga aggtgtacgg ctacaggggc 2400aagcacctgg gcggctccag
gaagcccgac ggcgccatct acaccgtggg ctcccccatc 2460gactacggcg
tgatcgtgga caccaaggcc tactccggcg gctacaacct gcccatcggc
2520caggccgacg aaatgcagag gtacgtggag gagaaccaga ccaggaacaa
gcacatcaac 2580cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg
agttcaagtt cctgttcgtg 2640tccggccact tcaagggcaa ctacaaggcc
cagctgacca ggctgaacca catcaccaac 2700tgcaacggcg ccgtgctgtc
cgtggaggag ctcctgatcg gcggcgagat gatcaaggcc 2760ggcaccctga
ccctggagga ggtgaggagg aagttcaaca acggcgagat caacttcgcg
2820gccgactgat aa 2832532814DNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotideTRBC_T02-L TALEN
53atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac
60gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc
120aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg
ccacgggttt 180acacacgcgc acatcgttgc gttaagccaa cacccggcag
cgttagggac cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca
gaggcgacac acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc
acgcgctctg gaggccttgc tcacggtggc gggagagttg 360agaggtccac
cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc
420gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc
cccgctcaac 480ttgaccccgg agcaggtggt ggccatcgcc agccacgatg
gcggcaagca ggcgctggag 540acggtccagc ggctgttgcc ggtgctgtgc
caggcccacg gcttgacccc ggagcaggtg 600gtggccatcg ccagccacga
tggcggcaag caggcgctgg agacggtcca gcggctgttg 660ccggtgctgt
gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac
720gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct
gtgccaggcc 780cacggcttga ccccggagca ggtggtggcc atcgccagca
atattggtgg caagcaggcg 840ctggagacgg tgcaggcgct gttgccggtg
ctgtgccagg cccacggctt gaccccggag 900caggtggtgg ccatcgccag
ccacgatggc ggcaagcagg cgctggagac ggtccagcgg 960ctgttgccgg
tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc
1020agccacgatg gcggcaagca ggcgctggag acggtccagc ggctgttgcc
ggtgctgtgc 1080caggcccacg gcttgacccc ggagcaggtg gtggccatcg
ccagccacga tggcggcaag 1140caggcgctgg agacggtcca gcggctgttg
ccggtgctgt gccaggccca cggcttgacc 1200ccccagcagg tggtggccat
cgccagcaat aatggtggca agcaggcgct ggagacggtc 1260cagcggctgt
tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc
1320atcgccagca atattggtgg caagcaggcg ctggagacgg tgcaggcgct
gttgccggtg 1380ctgtgccagg cccacggctt gaccccccag caggtggtgg
ccatcgccag caataatggt 1440ggcaagcagg cgctggagac ggtccagcgg
ctgttgccgg tgctgtgcca ggcccacggc 1500ttgacccccc agcaggtggt
ggccatcgcc agcaataatg gtggcaagca ggcgctggag 1560acggtccagc
ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg
1620gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca
gcggctgttg 1680ccggtgctgt gccaggccca cggcttgacc ccggagcagg
tggtggccat cgccagccac 1740gatggcggca agcaggcgct ggagacggtc
cagcggctgt tgccggtgct gtgccaggcc 1800cacggcttga ccccccagca
ggtggtggcc atcgccagca ataatggtgg caagcaggcg 1860ctggagacgg
tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag
1920caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac
ggtccagcgg 1980ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc
agcaggtggt ggccatcgcc 2040agcaatggcg gcggcaggcc ggcgctggag
agcattgttg cccagttatc tcgccctgat 2100ccggcgttgg ccgcgttgac
caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt 2160cctgcgctgg
atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg
2220aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta
cgtgccccac 2280gagtacatcg agctgatcga gatcgcccgg aacagcaccc
aggaccgtat cctggagatg 2340aaggtgatgg agttcttcat gaaggtgtac
ggctacaggg gcaagcacct gggcggctcc 2400aggaagcccg acggcgccat
ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg 2460gacaccaagg
cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag
2520aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga
gtggtggaag 2580gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg
tgtccggcca cttcaagggc 2640aactacaagg cccagctgac caggctgaac
cacatcacca actgcaacgg cgccgtgctg 2700tccgtggagg agctcctgat
cggcggcgag atgatcaagg ccggcaccct gaccctggag 2760gaggtgagga
ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa
2814542832DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotideTRBC_T02-R TALEN 54atgggcgatc ctaaaaagaa
acgtaaggtc atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag
catcgatatc gccgatctac gcacgctcgg ctacagccag 120cagcaacagg
agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca
180ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca
cccggcagcg 240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag
cgttgccaga ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg
tccggcgcac gcgctctgga ggccttgctc 360acggtggcgg gagagttgag
aggtccaccg ttacagttgg acacaggcca acttctcaag 420attgcaaaac
gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg
480acgggtgccc cgctcaactt gaccccccag caggtggtgg ccatcgccag
caataatggt 540ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 600ttgacccccc agcaggtggt ggccatcgcc
agcaataatg gtggcaagca ggcgctggag 660acggtccagc ggctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg 720gtggccatcg
ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg
780ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat
cgccagcaat 840attggtggca agcaggcgct ggagacggtg caggcgctgt
tgccggtgct gtgccaggcc 900cacggcttga ccccccagca ggtggtggcc
atcgccagca ataatggtgg caagcaggcg 960ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccggag 1020caggtggtgg
ccatcgccag caatattggt ggcaagcagg cgctggagac ggtgcaggcg
1080ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt
ggccatcgcc 1140agcaatggcg gtggcaagca ggcgctggag acggtccagc
ggctgttgcc ggtgctgtgc 1200caggcccacg gcttgacccc ggagcaggtg
gtggccatcg ccagccacga tggcggcaag 1260caggcgctgg agacggtcca
gcggctgttg ccggtgctgt gccaggccca cggcttgacc 1320ccccagcagg
tggtggccat cgccagcaat ggcggtggca agcaggcgct ggagacggtc
1380cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca
ggtggtggcc 1440atcgccagcc acgatggcgg caagcaggcg ctggagacgg
tccagcggct gttgccggtg 1500ctgtgccagg cccacggctt gaccccccag
caggtggtgg ccatcgccag caatggcggt 1560ggcaagcagg cgctggagac
ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc 1620ttgacccccc
agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag
1680acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc
ggagcaggtg 1740gtggccatcg ccagccacga tggcggcaag caggcgctgg
agacggtcca gcggctgttg 1800ccggtgctgt gccaggccca cggcttgacc
ccccagcagg tggtggccat cgccagcaat 1860ggcggtggca agcaggcgct
ggagacggtc cagcggctgt tgccggtgct gtgccaggcc 1920cacggcttga
ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg
1980ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt
gacccctcag 2040caggtggtgg ccatcgccag caatggcggc ggcaggccgg
cgctggagag cattgttgcc 2100cagttatctc gccctgatcc ggcgttggcc
gcgttgacca acgaccacct cgtcgccttg 2160gcctgcctcg gcgggcgtcc
tgcgctggat gcagtgaaaa agggattggg ggatcctatc 2220agccgttccc
agctggtgaa gtccgagctg gaggagaaga aatccgagtt gaggcacaag
2280ctgaagtacg tgccccacga gtacatcgag ctgatcgaga tcgcccggaa
cagcacccag 2340gaccgtatcc tggagatgaa ggtgatggag ttcttcatga
aggtgtacgg ctacaggggc 2400aagcacctgg gcggctccag gaagcccgac
ggcgccatct acaccgtggg ctcccccatc 2460gactacggcg tgatcgtgga
caccaaggcc tactccggcg gctacaacct gcccatcggc 2520caggccgacg
aaatgcagag gtacgtggag gagaaccaga ccaggaacaa gcacatcaac
2580cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt
cctgttcgtg 2640tccggccact tcaagggcaa ctacaaggcc cagctgacca
ggctgaacca catcaccaac 2700tgcaacggcg ccgtgctgtc cgtggaggag
ctcctgatcg gcggcgagat gatcaaggcc 2760ggcaccctga ccctggagga
ggtgaggagg aagttcaaca acggcgagat caacttcgcg 2820gccgactgat aa
2832552814DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotideCD52_T02-L TALEN 55atgggcgatc ctaaaaagaa
acgtaaggtc atcgattacc catacgatgt tccagattac 60gctatcgata tcgccgatct
acgcacgctc ggctacagcc agcagcaaca ggagaagatc 120aaaccgaagg
ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt
180acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac
cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca gaggcgacac
acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc acgcgctctg
gaggccttgc tcacggtggc gggagagttg 360agaggtccac cgttacagtt
ggacacaggc caacttctca agattgcaaa acgtggcggc 420gtgaccgcag
tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac
480ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca
ggcgctggag 540acggtccagc ggctgttgcc ggtgctgtgc caggcccacg
gcttgacccc ggagcaggtg 600gtggccatcg ccagccacga tggcggcaag
caggcgctgg agacggtcca gcggctgttg 660ccggtgctgt gccaggccca
cggcttgacc ccggagcagg tggtggccat cgccagccac 720gatggcggca
agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc
780cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg
caagcaggcg 840ctggagacgg tccagcggct gttgccggtg ctgtgccagg
cccacggctt gaccccggag 900caggtggtgg ccatcgccag ccacgatggc
ggcaagcagg cgctggagac ggtccagcgg 960ctgttgccgg tgctgtgcca
ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc 1020agccacgatg
gcggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc
1080caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaatgg
cggtggcaag 1140caggcgctgg agacggtcca gcggctgttg ccggtgctgt
gccaggccca cggcttgacc 1200ccggagcagg tggtggccat cgccagcaat
attggtggca agcaggcgct ggagacggtg 1260caggcgctgt tgccggtgct
gtgccaggcc cacggcttga ccccggagca ggtggtggcc 1320atcgccagcc
acgatggcgg caagcaggcg ctggagacgg tccagcggct gttgccggtg
1380ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag
caatggcggt 1440ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 1500ttgaccccgg agcaggtggt ggccatcgcc
agccacgatg gcggcaagca ggcgctggag 1560acggtccagc ggctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg 1620gtggccatcg
ccagcaatat tggtggcaag caggcgctgg agacggtgca ggcgctgttg
1680ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat
cgccagccac 1740gatggcggca agcaggcgct ggagacggtc cagcggctgt
tgccggtgct gtgccaggcc 1800cacggcttga ccccggagca ggtggtggcc
atcgccagcc acgatggcgg caagcaggcg 1860ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccggag 1920caggtggtgg
ccatcgccag caatattggt ggcaagcagg cgctggagac ggtgcaggcg
1980ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt
ggccatcgcc 2040agcaatggcg gcggcaggcc ggcgctggag agcattgttg
cccagttatc tcgccctgat 2100ccggcgttgg ccgcgttgac caacgaccac
ctcgtcgcct tggcctgcct cggcgggcgt 2160cctgcgctgg atgcagtgaa
aaagggattg ggggatccta tcagccgttc ccagctggtg 2220aagtccgagc
tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac
2280gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat
cctggagatg 2340aaggtgatgg agttcttcat gaaggtgtac ggctacaggg
gcaagcacct gggcggctcc 2400aggaagcccg acggcgccat ctacaccgtg
ggctccccca tcgactacgg cgtgatcgtg 2460gacaccaagg cctactccgg
cggctacaac ctgcccatcg gccaggccga cgaaatgcag 2520aggtacgtgg
aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag
2580gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca
cttcaagggc 2640aactacaagg cccagctgac caggctgaac cacatcacca
actgcaacgg cgccgtgctg 2700tccgtggagg agctcctgat cggcggcgag
atgatcaagg ccggcaccct gaccctggag 2760gaggtgagga ggaagttcaa
caacggcgag atcaacttcg cggccgactg ataa 2814562832DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
polynucleotideCD52_T02-R TALEN 56atgggcgatc ctaaaaagaa acgtaaggtc
atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag catcgatatc
gccgatctac gcacgctcgg ctacagccag 120cagcaacagg agaagatcaa
accgaaggtt cgttcgacag tggcgcagca ccacgaggca 180ctggtcggcc
acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg
240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga
ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac
gcgctctgga ggccttgctc 360acggtggcgg gagagttgag aggtccaccg
ttacagttgg acacaggcca acttctcaag 420attgcaaaac gtggcggcgt
gaccgcagtg gaggcagtgc atgcatggcg caatgcactg 480acgggtgccc
cgctcaactt gaccccccag caggtggtgg ccatcgccag caatggcggt
540ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca
ggcccacggc 600ttgacccccc agcaggtggt ggccatcgcc agcaataatg
gtggcaagca ggcgctggag 660acggtccagc ggctgttgcc ggtgctgtgc
caggcccacg gcttgacccc ggagcaggtg 720gtggccatcg ccagccacga
tggcggcaag caggcgctgg agacggtcca gcggctgttg 780ccggtgctgt
gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat
840ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct
gtgccaggcc 900cacggcttga ccccggagca ggtggtggcc atcgccagcc
acgatggcgg caagcaggcg 960ctggagacgg tccagcggct gttgccggtg
ctgtgccagg cccacggctt gaccccccag 1020caggtggtgg ccatcgccag
caatggcggt ggcaagcagg cgctggagac ggtccagcgg 1080ctgttgccgg
tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc
1140agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc
ggtgctgtgc 1200caggcccacg gcttgacccc ggagcaggtg gtggccatcg
ccagcaatat tggtggcaag 1260caggcgctgg agacggtgca ggcgctgttg
ccggtgctgt gccaggccca cggcttgacc 1320ccggagcagg tggtggccat
cgccagccac gatggcggca agcaggcgct ggagacggtc 1380cagcggctgt
tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc
1440atcgccagcc acgatggcgg caagcaggcg ctggagacgg tccagcggct
gttgccggtg 1500ctgtgccagg cccacggctt gaccccccag caggtggtgg
ccatcgccag caatggcggt 1560ggcaagcagg cgctggagac ggtccagcgg
ctgttgccgg tgctgtgcca ggcccacggc 1620ttgacccccc agcaggtggt
ggccatcgcc agcaataatg gtggcaagca ggcgctggag 1680acggtccagc
ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg
1740gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca
gcggctgttg 1800ccggtgctgt gccaggccca cggcttgacc ccggagcagg
tggtggccat cgccagcaat 1860attggtggca agcaggcgct ggagacggtg
caggcgctgt tgccggtgct gtgccaggcc 1920cacggcttga ccccggagca
ggtggtggcc atcgccagcc acgatggcgg caagcaggcg 1980ctggagacgg
tccagcggct gttgccggtg ctgtgccagg cccacggctt gacccctcag
2040caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag
cattgttgcc 2100cagttatctc gccctgatcc ggcgttggcc gcgttgacca
acgaccacct cgtcgccttg 2160gcctgcctcg gcgggcgtcc tgcgctggat
gcagtgaaaa agggattggg ggatcctatc 2220agccgttccc agctggtgaa
gtccgagctg gaggagaaga aatccgagtt gaggcacaag 2280ctgaagtacg
tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag
2340gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg
ctacaggggc 2400aagcacctgg gcggctccag gaagcccgac ggcgccatct
acaccgtggg ctcccccatc 2460gactacggcg tgatcgtgga caccaaggcc
tactccggcg gctacaacct gcccatcggc 2520caggccgacg aaatgcagag
gtacgtggag gagaaccaga ccaggaacaa gcacatcaac 2580cccaacgagt
ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg
2640tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca
catcaccaac 2700tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg
gcggcgagat gatcaaggcc 2760ggcaccctga ccctggagga ggtgaggagg
aagttcaaca acggcgagat caacttcgcg 2820gccgactgat aa
28325749DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideTRAC_T02 57tttagaaagt tcctgtgatg
tcaagctggt cgagaaaagc tttgaaaca 495849DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideTRAC_T03 58tccagtgaca agtctgtctg cctattcacc
gattttgatt ctcaaacaa 495949DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotideTRAC_T04 59tatatcacag
acaaaactgt gctagacatg aggtctatgg acttcaaga 496049DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideTRAC_T05 60tgaggtctat ggacttcaag agcaacagtg
ctgtggcctg gagcaacaa 496147DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotideCD52_T01 61ttcctcttcc
tcctaccacc atcagcctcc tttacctgta ccataac 476243DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideCD52_T04 62ttcctcctac tcaccacagc ctcctggtct
tacctgtacc ata 436343DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotideCD52_T05 63tcctactcac
catcagctcc tggttatttg ctcttacctg tac 436447DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideCD52_T06 64ttatcccact tctcctctac agatacaaac
tttttgtcct gagagtc 476547DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotideCD52_T07 65tggactctca
ggacaaacga caccagccaa atgctgaggg gctgctg 476660DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideForward composite primer for CD52, including SEQ ID
NO 128, 10N tag, and SEQ ID NO 136modified_base(31)..(40)a, c, t or
g 66ccatctcatc cctgcgtgtc tccgactcag nnnnnnnnnn cagatctgca
gaaaggaagc 606761DNAArtificial SequenceDescription of Artificial
Sequence Synthetic oligonucleotideForward composite primer for
TRAC, including SEQ ID NO 128, 10N tag, and SEQ ID NO
137modified_base(31)..(40)a, c, t or g 67ccatctcatc cctgcgtgtc
tccgactcag nnnnnnnnnn atcactggca tctggactcc 60a 616862DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideForward composite primer for TRBC1, including
SEQ
ID NO 128, 10N tag, and SEQ ID NO 138modified_base(31)..(40)a, c, t
or g 68ccatctcatc cctgcgtgtc tccgactcag nnnnnnnnnn agagccccta
ccagaaccag 60ac 626962DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotideForward composite
primer for TRBC2, including SEQ ID NO 128, 10N tag, and SEQ ID NO
139modified_base(31)..(40)a, c, t or g 69ccatctcatc cctgcgtgtc
tccgactcag nnnnnnnnnn ggacctagta acataattgt 60gc
627051DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideReverse composite primer for CD52,
including SEQ ID NO 132 and SEQ ID NO 140 70cctatcccct gtgtgccttg
gcagtctcag cctgttggag tccatctgct g 517150DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideReverse composite primer for TRAC, including SEQ ID
NO 132 and SEQ ID NO 141 71cctatcccct gtgtgccttg gcagtctcag
cctcatgtct agcacagttt 507251DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotideReverse composite
primer for TRBC1 and TRBC2, including SEQ ID NO 132 and SEQ ID NO
142 72cctatcccct gtgtgccttg gcagtctcag accagctcag ctccacgtgg t
5173495PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideanti-CD19 CAR 73Met Glu Thr Asp Thr Leu Leu
Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Glu
Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile 20 25 30 Lys Pro Gly
Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 35 40 45 Phe
Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly 50 55
60 Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr
65 70 75 80 Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys
Ser Ser 85 90 95 Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser
Glu Asp Ser Ala 100 105 110 Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr
Tyr Gly Ser Arg Val Phe 115 120 125 Asp Tyr Trp Gly Gln Gly Thr Thr
Leu Thr Val Ser Ser Gly Gly Gly 130 135 140 Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Asp Ile Val Met 145 150 155 160 Thr Gln Ala
Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser 165 170 175 Ile
Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr 180 185
190 Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu
195 200 205 Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg
Phe Ser 210 215 220 Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile
Ser Arg Val Glu 225 230 235 240 Ala Glu Asp Val Gly Val Tyr Tyr Cys
Met Gln His Leu Glu Tyr Pro 245 250 255 Phe Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys Arg Ser Asp Pro 260 265 270 Thr Thr Thr Pro Ala
Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 275 280 285 Ser Gln Pro
Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 290 295 300 Gly
Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 305 310
315 320 Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu
Val 325 330 335 Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu
Tyr Ile Phe 340 345 350 Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr
Gln Glu Glu Asp Gly 355 360 365 Cys Ser Cys Arg Phe Pro Glu Glu Glu
Glu Gly Gly Cys Glu Leu Arg 370 375 380 Val Lys Phe Ser Arg Ser Ala
Asp Ala Pro Ala Tyr Gln Gln Gly Gln 385 390 395 400 Asn Gln Leu Tyr
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 405 410 415 Val Leu
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 420 425 430
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 435
440 445 Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
Arg 450 455 460 Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser
Thr Ala Thr 465 470 475 480 Lys Asp Thr Tyr Asp Ala Leu His Met Gln
Ala Leu Pro Pro Arg 485 490 495 7449DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideCTLA4_T01 74tggccctgca ctctcctgtt ttttcttctc
ttcatccctg tcttctgca 497549DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotideCTLA4_T03 75ttttccatgc
tagcaatgca cgtggcccag cctgctgtgg tactggcca 497649DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideCTLA4_T04 76tccatgctag caatgcacgt ggcccagcct
gctgtggtac tggccagca 497749DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotidePDCD1_T01 77ttctccccag
ccctgctcgt ggtgaccgaa ggggacaacg ccaccttca 497849DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotidePDCD1_T03 78tacctctgtg gggccatctc cctggccccc
aaggcgcaga tcaaagaga 4979530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat CTLA4_T01-L 79Leu
Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 1 5 10
15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
20 25 30 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn
Asn Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val
Val Ala Ile Ala Ser His 65 70 75 80 Asp Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala 100 105 110 Ser His Asp Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140
Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145
150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln
Gln Val 165 170 175 Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala
Leu Glu Thr Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn
Asn Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln
Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 245 250 255 Leu
Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265
270 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys
275 280 285 Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys
Gln Ala 290 295 300 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala
Ser His Asp Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro
Gln Gln Val Val Ala Ile Ala Ser Asn 340 345 350 Gly Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln
Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 370 375 380 Ser
His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390
395 400 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val
Ala 405 410 415 Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr
Val Gln Arg 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Glu Gln Val 435 440 445 Val Ala Ile Ala Ser His Asp Gly Gly
Lys Gln Ala Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala
Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510
Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515
520 525 Leu Glu 530 80530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat CTLA4_T01-R 80Leu
Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 1 5 10
15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
20 25 30 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His
Asp Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val
Val Ala Ile Ala Ser Asn 65 70 75 80 Ile Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Ala Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly
Leu Thr Pro Gln Gln Val Val Ala Ile Ala 100 105 110 Ser Asn Asn Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140
Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 145
150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu
Gln Val 165 170 175 Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala
Leu Glu Thr Val 180 185 190 Gln Ala Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn
Asn Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln
Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 245 250 255 Leu
Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265
270 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys
275 280 285 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys
Gln Ala 290 295 300 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala
Ser Asn Ile Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln
Ala Leu Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro
Gln Gln Val Val Ala Ile Ala Ser Asn 340 345 350 Asn Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln
Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 370 375 380 Ser
Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390
395 400 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val
Ala 405 410 415 Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr
Val Gln Arg 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Glu Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Ile Gly Gly
Lys Gln Ala Leu Glu Thr Val 450 455 460 Gln Ala Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Gln 465 470 475 480 Gln Val Val Ala
Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510
Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515
520 525 Leu Glu 530 81530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat CTLA4_T03-L 81Leu
Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 1 5 10
15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
20 25 30 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn
Gly Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn 65 70 75 80 Gly Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala 100 105 110 Ser His Asp Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140
Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145
150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu
Gln Val 165 170 175 Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala
Leu Glu Thr Val 180 185 190 Gln Ala Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn
Gly Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Gln Gln
Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 245 250 255 Leu
Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265
270 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys
275 280 285 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys
Gln Ala 290 295 300 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala
Ser Asn Gly Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro
Glu Gln Val Val Ala Ile Ala Ser Asn 340 345 350 Ile Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 355 360 365 Leu Cys Gln
Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 370 375 380 Ser
Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390
395
400 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala
405 410 415 Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val
Gln Arg 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr
Pro Glu Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Ile Gly Gly Lys
Gln Ala Leu Glu Thr Val 450 455 460 Gln Ala Leu Leu Pro Val Leu Cys
Gln Ala His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala Ile
Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln
Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro
Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520
525 Leu Glu 530 82530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat CTLA4_T03-R 82Leu
Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 1 5 10
15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
20 25 30 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn
Asn Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val
Val Ala Ile Ala Ser His 65 70 75 80 Asp Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala 100 105 110 Ser His Asp Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140
Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 145
150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln
Gln Val 165 170 175 Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala
Leu Glu Thr Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn
Gly Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln
Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 245 250 255 Leu
Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265
270 Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys
275 280 285 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys
Gln Ala 290 295 300 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala
Ser His Asp Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro
Glu Gln Val Val Ala Ile Ala Ser Asn 340 345 350 Ile Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 355 360 365 Leu Cys Gln
Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 370 375 380 Ser
His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390
395 400 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val
Ala 405 410 415 Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr
Val Gln Ala 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Gln Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Asn Gly Gly
Lys Gln Ala Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala
Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510
Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515
520 525 Leu Glu 530 83530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat CTLA4_T04-L 83Leu
Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 1 5 10
15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
20 25 30 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His
Asp Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val
Val Ala Ile Ala Ser Asn 65 70 75 80 Ile Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Ala Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly
Leu Thr Pro Gln Gln Val Val Ala Ile Ala 100 105 110 Ser Asn Gly Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 130 135 140
Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145
150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu
Gln Val 165 170 175 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala
Leu Glu Thr Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn
Gly Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln
Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 245 250 255 Leu
Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265
270 Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys
275 280 285 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys
Gln Ala 290 295 300 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala
Ser His Asp Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro
Glu Gln Val Val Ala Ile Ala Ser Asn 340 345 350 Ile Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 355 360 365 Leu Cys Gln
Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 370 375 380 Ser
Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 385 390
395 400 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val
Ala 405 410 415 Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr
Val Gln Arg 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Gln Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Asn Gly Gly
Lys Gln Ala Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala
Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510
Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515
520 525 Leu Glu 530 84530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat CTLA4_T04-R 84Leu
Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 1 5 10
15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
20 25 30 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His
Asp Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn 65 70 75 80 Gly Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly
Leu Thr Pro Gln Gln Val Val Ala Ile Ala 100 105 110 Ser Asn Asn Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 130 135 140
Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145
150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu
Gln Val 165 170 175 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala
Leu Glu Thr Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Glu 195 200 205 Gln Val Val Ala Ile Ala Ser His
Asp Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln
Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 245 250 255 Leu
Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265
270 Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys
275 280 285 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys
Gln Ala 290 295 300 His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala
Ser Asn Gly Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro
Glu Gln Val Val Ala Ile Ala Ser Asn 340 345 350 Ile Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 355 360 365 Leu Cys Gln
Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 370 375 380 Ser
His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390
395 400 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val
Ala 405 410 415 Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr
Val Gln Arg 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Glu Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Ile Gly Gly
Lys Gln Ala Leu Glu Thr Val 450 455 460 Gln Ala Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala
Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510
Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515
520 525 Leu Glu 530 85530PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideRepeat PDCD1_T01-L 85Leu
Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 1 5 10
15 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
20 25 30 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His
Asp Gly 35 40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu
Pro Val Leu Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Gln Gln Val
Val Ala Ile Ala Ser Asn 65 70 75 80 Gly Gly Gly Lys Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala 100 105 110 Ser His Asp Gly
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140
Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145
150 155 160 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu
Gln Val 165 170 175 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala
Leu Glu Thr Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
His Gly Leu Thr Pro Glu 195 200 205 Gln Val Val Ala Ile Ala Ser His
Asp Gly Gly Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln
Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 245 250 255 Leu
Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265
270 Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys
275 280 285 Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys
Gln Ala 290 295 300 His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala
Ser His Asp Gly 305 310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln
Arg Leu Leu Pro Val Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro
Glu Gln Val Val Ala Ile Ala Ser His 340 345 350 Asp Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln
Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 370 375 380 Ser
His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390
395 400 Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val
Ala 405 410 415 Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr
Val Gln Arg 420 425 430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Gln Gln Val 435 440 445 Val Ala Ile Ala Ser Asn Asn Gly Gly
Lys Gln Ala Leu Glu Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala
Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510
Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515
520 525
Leu Glu 530 86529PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptideRepeat PDCD1_T01-R 86Leu Thr Pro Gln
Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 1 5 10 15 Gln Ala
Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30
His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 35
40 45 Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu
Cys 50 55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile
Ala Ser Asn 65 70 75 80 Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln
Ala Leu Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro
Gln Gln Val Val Ala Ile Ala 100 105 110 Ser Asn Asn Gly Gly Lys Gln
Ala Leu Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val Leu Cys Gln
Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 130 135 140 Ile Ala Ser
Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145 150 155 160
Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 165
170 175 Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr
Val 180 185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly
Lys Gln Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu
Cys Gln Ala His Gly Leu Thr 225 230 235 240 Pro Gln Gln Val Val Ala
Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val
Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr
Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Lys Gln 275 280 285
Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 290
295 300 Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly
Gly 305 310 315 320 Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro
Val Leu Cys Gln 325 330 335 Ala His Gly Leu Thr Pro Gln Gln Val Val
Ala Ile Ala Ser Asn Gly 340 345 350 Gly Gly Lys Gln Ala Leu Glu Thr
Val Gln Arg Leu Leu Pro Val Leu 355 360 365 Cys Gln Ala His Gly Leu
Thr Pro Gln Gln Val Val Ala Ile Ala Ser 370 375 380 Asn Gly Gly Gly
Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 385 390 395 400 Val
Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 405 410
415 Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu
420 425 430 Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln
Val Val 435 440 445 Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu
Glu Thr Val Gln 450 455 460 Arg Leu Leu Pro Val Leu Cys Gln Ala His
Gly Leu Thr Pro Glu Gln 465 470 475 480 Val Val Ala Ile Ala Ser His
Asp Gly Gly Lys Gln Ala Leu Glu Thr 485 490 495 Val Gln Arg Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 500 505 510 Gln Gln Val
Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala Leu 515 520 525 Glu
87530PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideRepeat PDCD1_T03-L 87Leu Thr Pro Glu Gln Val
Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu
Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 20 25 30 His Gly
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 35 40 45
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 50
55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser
His 65 70 75 80 Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu
Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln
Val Val Ala Ile Ala 100 105 110 Ser Asn Gly Gly Gly Lys Gln Ala Leu
Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val Leu Cys Gln Ala His
Gly Leu Thr Pro Glu Gln Val Val Ala 130 135 140 Ile Ala Ser His Asp
Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145 150 155 160 Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 165 170 175
Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 180
185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro
Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln
Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln
Ala His Gly Leu Thr 225 230 235 240 Pro Gln Gln Val Val Ala Ile Ala
Ser Asn Gly Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val Gln Arg
Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr Pro Gln
Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 275 280 285 Gln Ala
Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 290 295 300
His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 305
310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val
Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala
Ile Ala Ser Asn 340 345 350 Asn Gly Gly Lys Gln Ala Leu Glu Thr Val
Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly Leu Thr
Pro Gln Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Asn Gly Gly Lys
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390 395 400 Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 405 410 415 Ile
Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 420 425
430 Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val
435 440 445 Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu
Thr Val 450 455 460 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly
Leu Thr Pro Glu 465 470 475 480 Gln Val Val Ala Ile Ala Ser Asn Ile
Gly Gly Lys Gln Ala Leu Glu 485 490 495 Thr Val Gln Ala Leu Leu Pro
Val Leu Cys Gln Ala His Gly Leu Thr 500 505 510 Pro Gln Gln Val Val
Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 515 520 525 Leu Glu 530
88529PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptideRepeat PDCD1_T03-R 88Leu Thr Pro Glu Gln Val
Val Ala Ile Ala Ser His Asp Gly Gly Lys 1 5 10 15 Gln Ala Leu Glu
Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 20 25 30 His Gly
Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 35 40 45
Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 50
55 60 Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser
His 65 70 75 80 Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu
Leu Pro Val 85 90 95 Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln
Val Val Ala Ile Ala 100 105 110 Ser Asn Gly Gly Gly Lys Gln Ala Leu
Glu Thr Val Gln Arg Leu Leu 115 120 125 Pro Val Leu Cys Gln Ala His
Gly Leu Thr Pro Gln Gln Val Val Ala 130 135 140 Ile Ala Ser Asn Gly
Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 145 150 155 160 Leu Leu
Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 165 170 175
Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 180
185 190 Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro
Gln 195 200 205 Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln
Ala Leu Glu 210 215 220 Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln
Ala His Gly Leu Thr 225 230 235 240 Pro Glu Gln Val Val Ala Ile Ala
Ser Asn Ile Gly Gly Lys Gln Ala 245 250 255 Leu Glu Thr Val Gln Ala
Leu Leu Pro Val Leu Cys Gln Ala His Gly 260 265 270 Leu Thr Pro Gln
Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 275 280 285 Gln Ala
Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 290 295 300
His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 305
310 315 320 Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val
Leu Cys 325 330 335 Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala
Ile Ala Ser Asn 340 345 350 Gly Gly Gly Lys Gln Ala Leu Glu Thr Val
Gln Arg Leu Leu Pro Val 355 360 365 Leu Cys Gln Ala His Gly Leu Thr
Pro Gln Gln Val Val Ala Ile Ala 370 375 380 Ser Asn Asn Gly Gly Lys
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 385 390 395 400 Pro Val Leu
Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 405 410 415 Ile
Ala Ser Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 420 425
430 Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val
435 440 445 Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr
Val Gln 450 455 460 Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu
Thr Pro Glu Gln 465 470 475 480 Val Val Ala Ile Ala Ser His Asp Gly
Gly Lys Gln Ala Leu Glu Thr 485 490 495 Val Gln Arg Leu Leu Pro Val
Leu Cys Gln Ala His Gly Leu Thr Pro 500 505 510 Gln Gln Val Val Ala
Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala Leu 515 520 525 Glu
892814DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotideCTLA4_T01-L TALEN 89atgggcgatc ctaaaaagaa
acgtaaggtc atcgattacc catacgatgt tccagattac 60gctatcgata tcgccgatct
acgcacgctc ggctacagcc agcagcaaca ggagaagatc 120aaaccgaagg
ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt
180acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac
cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca gaggcgacac
acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc acgcgctctg
gaggccttgc tcacggtggc gggagagttg 360agaggtccac cgttacagtt
ggacacaggc caacttctca agattgcaaa acgtggcggc 420gtgaccgcag
tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac
480ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca
ggcgctggag 540acggtccagc ggctgttgcc ggtgctgtgc caggcccacg
gcttgacccc ccagcaggtg 600gtggccatcg ccagcaataa tggtggcaag
caggcgctgg agacggtcca gcggctgttg 660ccggtgctgt gccaggccca
cggcttgacc ccggagcagg tggtggccat cgccagccac 720gatggcggca
agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc
780cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg
caagcaggcg 840ctggagacgg tccagcggct gttgccggtg ctgtgccagg
cccacggctt gaccccggag 900caggtggtgg ccatcgccag ccacgatggc
ggcaagcagg cgctggagac ggtccagcgg 960ctgttgccgg tgctgtgcca
ggcccacggc ttgacccccc agcaggtggt ggccatcgcc 1020agcaatggcg
gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc
1080caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaataa
tggtggcaag 1140caggcgctgg agacggtcca gcggctgttg ccggtgctgt
gccaggccca cggcttgacc 1200ccggagcagg tggtggccat cgccagccac
gatggcggca agcaggcgct ggagacggtc 1260cagcggctgt tgccggtgct
gtgccaggcc cacggcttga ccccggagca ggtggtggcc 1320atcgccagca
atattggtgg caagcaggcg ctggagacgg tgcaggcgct gttgccggtg
1380ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag
ccacgatggc 1440ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 1500ttgacccccc agcaggtggt ggccatcgcc
agcaatggcg gtggcaagca ggcgctggag 1560acggtccagc ggctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg 1620gtggccatcg
ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg
1680ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat
cgccagcaat 1740ggcggtggca agcaggcgct ggagacggtc cagcggctgt
tgccggtgct gtgccaggcc 1800cacggcttga ccccggagca ggtggtggcc
atcgccagcc acgatggcgg caagcaggcg 1860ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccggag 1920caggtggtgg
ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg
1980ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt
ggccatcgcc 2040agcaatggcg gcggcaggcc ggcgctggag agcattgttg
cccagttatc tcgccctgat 2100ccggcgttgg ccgcgttgac caacgaccac
ctcgtcgcct tggcctgcct cggcgggcgt 2160cctgcgctgg atgcagtgaa
aaagggattg ggggatccta tcagccgttc ccagctggtg 2220aagtccgagc
tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac
2280gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat
cctggagatg 2340aaggtgatgg agttcttcat gaaggtgtac ggctacaggg
gcaagcacct gggcggctcc 2400aggaagcccg acggcgccat ctacaccgtg
ggctccccca tcgactacgg cgtgatcgtg 2460gacaccaagg cctactccgg
cggctacaac ctgcccatcg gccaggccga cgaaatgcag 2520aggtacgtgg
aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag
2580gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca
cttcaagggc 2640aactacaagg cccagctgac caggctgaac cacatcacca
actgcaacgg cgccgtgctg 2700tccgtggagg agctcctgat cggcggcgag
atgatcaagg ccggcaccct gaccctggag 2760gaggtgagga ggaagttcaa
caacggcgag atcaacttcg cggccgactg ataa 2814902832DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
polynucleotideCTLA4_T01-R TALEN 90atgggcgatc ctaaaaagaa acgtaaggtc
atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag catcgatatc
gccgatctac gcacgctcgg ctacagccag 120cagcaacagg agaagatcaa
accgaaggtt cgttcgacag tggcgcagca ccacgaggca 180ctggtcggcc
acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg
240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga
ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac
gcgctctgga ggccttgctc 360acggtggcgg gagagttgag aggtccaccg
ttacagttgg acacaggcca acttctcaag 420attgcaaaac gtggcggcgt
gaccgcagtg gaggcagtgc atgcatggcg caatgcactg 480acgggtgccc
cgctcaactt gaccccccag caggtggtgg ccatcgccag caataatggt
540ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca
ggcccacggc 600ttgaccccgg agcaggtggt ggccatcgcc agccacgatg
gcggcaagca ggcgctggag 660acggtccagc ggctgttgcc ggtgctgtgc
caggcccacg gcttgacccc ggagcaggtg 720gtggccatcg ccagcaatat
tggtggcaag caggcgctgg agacggtgca ggcgctgttg 780ccggtgctgt
gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat
840aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct
gtgccaggcc 900cacggcttga ccccggagca ggtggtggcc atcgccagca
atattggtgg caagcaggcg 960ctggagacgg tgcaggcgct gttgccggtg
ctgtgccagg cccacggctt gaccccggag 1020caggtggtgg ccatcgccag
caatattggt ggcaagcagg cgctggagac ggtgcaggcg 1080ctgttgccgg
tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc
1140agcaataatg gtggcaagca ggcgctggag acggtccagc ggctgttgcc
ggtgctgtgc 1200caggcccacg gcttgacccc ggagcaggtg gtggccatcg
ccagcaatat tggtggcaag 1260caggcgctgg agacggtgca ggcgctgttg
ccggtgctgt gccaggccca cggcttgacc 1320ccggagcagg tggtggccat
cgccagccac
gatggcggca agcaggcgct ggagacggtc 1380cagcggctgt tgccggtgct
gtgccaggcc cacggcttga ccccggagca ggtggtggcc 1440atcgccagca
atattggtgg caagcaggcg ctggagacgg tgcaggcgct gttgccggtg
1500ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag
caataatggt 1560ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 1620ttgacccccc agcaggtggt ggccatcgcc
agcaataatg gtggcaagca ggcgctggag 1680acggtccagc ggctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg 1740gtggccatcg
ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg
1800ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat
cgccagcaat 1860attggtggca agcaggcgct ggagacggtg caggcgctgt
tgccggtgct gtgccaggcc 1920cacggcttga ccccccagca ggtggtggcc
atcgccagca atggcggtgg caagcaggcg 1980ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gacccctcag 2040caggtggtgg
ccatcgccag caatggcggc ggcaggccgg cgctggagag cattgttgcc
2100cagttatctc gccctgatcc ggcgttggcc gcgttgacca acgaccacct
cgtcgccttg 2160gcctgcctcg gcgggcgtcc tgcgctggat gcagtgaaaa
agggattggg ggatcctatc 2220agccgttccc agctggtgaa gtccgagctg
gaggagaaga aatccgagtt gaggcacaag 2280ctgaagtacg tgccccacga
gtacatcgag ctgatcgaga tcgcccggaa cagcacccag 2340gaccgtatcc
tggagatgaa ggtgatggag ttcttcatga aggtgtacgg ctacaggggc
2400aagcacctgg gcggctccag gaagcccgac ggcgccatct acaccgtggg
ctcccccatc 2460gactacggcg tgatcgtgga caccaaggcc tactccggcg
gctacaacct gcccatcggc 2520caggccgacg aaatgcagag gtacgtggag
gagaaccaga ccaggaacaa gcacatcaac 2580cccaacgagt ggtggaaggt
gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg 2640tccggccact
tcaagggcaa ctacaaggcc cagctgacca ggctgaacca catcaccaac
2700tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg gcggcgagat
gatcaaggcc 2760ggcaccctga ccctggagga ggtgaggagg aagttcaaca
acggcgagat caacttcgcg 2820gccgactgat aa 2832912814DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
polynucleotideCTLA4_T03-L TALEN 91atgggcgatc ctaaaaagaa acgtaaggtc
atcgattacc catacgatgt tccagattac 60gctatcgata tcgccgatct acgcacgctc
ggctacagcc agcagcaaca ggagaagatc 120aaaccgaagg ttcgttcgac
agtggcgcag caccacgagg cactggtcgg ccacgggttt 180acacacgcgc
acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc
240aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat
cgttggcgtc 300ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc
tcacggtggc gggagagttg 360agaggtccac cgttacagtt ggacacaggc
caacttctca agattgcaaa acgtggcggc 420gtgaccgcag tggaggcagt
gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac 480ttgacccccc
agcaggtggt ggccatcgcc agcaatggcg gtggcaagca ggcgctggag
540acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc
ccagcaggtg 600gtggccatcg ccagcaatgg cggtggcaag caggcgctgg
agacggtcca gcggctgttg 660ccggtgctgt gccaggccca cggcttgacc
ccccagcagg tggtggccat cgccagcaat 720ggcggtggca agcaggcgct
ggagacggtc cagcggctgt tgccggtgct gtgccaggcc 780cacggcttga
ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg
840ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt
gaccccggag 900caggtggtgg ccatcgccag ccacgatggc ggcaagcagg
cgctggagac ggtccagcgg 960ctgttgccgg tgctgtgcca ggcccacggc
ttgaccccgg agcaggtggt ggccatcgcc 1020agcaatattg gtggcaagca
ggcgctggag acggtgcagg cgctgttgcc ggtgctgtgc 1080caggcccacg
gcttgacccc ccagcaggtg gtggccatcg ccagcaatgg cggtggcaag
1140caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca
cggcttgacc 1200ccccagcagg tggtggccat cgccagcaat aatggtggca
agcaggcgct ggagacggtc 1260cagcggctgt tgccggtgct gtgccaggcc
cacggcttga ccccggagca ggtggtggcc 1320atcgccagcc acgatggcgg
caagcaggcg ctggagacgg tccagcggct gttgccggtg 1380ctgtgccagg
cccacggctt gaccccccag caggtggtgg ccatcgccag caatggcggt
1440ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca
ggcccacggc 1500ttgaccccgg agcaggtggt ggccatcgcc agcaatattg
gtggcaagca ggcgctggag 1560acggtgcagg cgctgttgcc ggtgctgtgc
caggcccacg gcttgacccc ccagcaggtg 1620gtggccatcg ccagcaataa
tggtggcaag caggcgctgg agacggtcca gcggctgttg 1680ccggtgctgt
gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac
1740gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct
gtgccaggcc 1800cacggcttga ccccggagca ggtggtggcc atcgccagca
atattggtgg caagcaggcg 1860ctggagacgg tgcaggcgct gttgccggtg
ctgtgccagg cccacggctt gaccccggag 1920caggtggtgg ccatcgccag
caatattggt ggcaagcagg cgctggagac ggtgcaggcg 1980ctgttgccgg
tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc
2040agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc
tcgccctgat 2100ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct
tggcctgcct cggcgggcgt 2160cctgcgctgg atgcagtgaa aaagggattg
ggggatccta tcagccgttc ccagctggtg 2220aagtccgagc tggaggagaa
gaaatccgag ttgaggcaca agctgaagta cgtgccccac 2280gagtacatcg
agctgatcga gatcgcccgg aacagcaccc aggaccgtat cctggagatg
2340aaggtgatgg agttcttcat gaaggtgtac ggctacaggg gcaagcacct
gggcggctcc 2400aggaagcccg acggcgccat ctacaccgtg ggctccccca
tcgactacgg cgtgatcgtg 2460gacaccaagg cctactccgg cggctacaac
ctgcccatcg gccaggccga cgaaatgcag 2520aggtacgtgg aggagaacca
gaccaggaac aagcacatca accccaacga gtggtggaag 2580gtgtacccct
ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca cttcaagggc
2640aactacaagg cccagctgac caggctgaac cacatcacca actgcaacgg
cgccgtgctg 2700tccgtggagg agctcctgat cggcggcgag atgatcaagg
ccggcaccct gaccctggag 2760gaggtgagga ggaagttcaa caacggcgag
atcaacttcg cggccgactg ataa 2814922832DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
polynucleotideCTLA4_T03-R TALEN 92atgggcgatc ctaaaaagaa acgtaaggtc
atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag catcgatatc
gccgatctac gcacgctcgg ctacagccag 120cagcaacagg agaagatcaa
accgaaggtt cgttcgacag tggcgcagca ccacgaggca 180ctggtcggcc
acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg
240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga
ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac
gcgctctgga ggccttgctc 360acggtggcgg gagagttgag aggtccaccg
ttacagttgg acacaggcca acttctcaag 420attgcaaaac gtggcggcgt
gaccgcagtg gaggcagtgc atgcatggcg caatgcactg 480acgggtgccc
cgctcaactt gaccccccag caggtggtgg ccatcgccag caataatggt
540ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca
ggcccacggc 600ttgacccccc agcaggtggt ggccatcgcc agcaataatg
gtggcaagca ggcgctggag 660acggtccagc ggctgttgcc ggtgctgtgc
caggcccacg gcttgacccc ggagcaggtg 720gtggccatcg ccagccacga
tggcggcaag caggcgctgg agacggtcca gcggctgttg 780ccggtgctgt
gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac
840gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct
gtgccaggcc 900cacggcttga ccccggagca ggtggtggcc atcgccagca
atattggtgg caagcaggcg 960ctggagacgg tgcaggcgct gttgccggtg
ctgtgccagg cccacggctt gaccccccag 1020caggtggtgg ccatcgccag
caataatggt ggcaagcagg cgctggagac ggtccagcgg 1080ctgttgccgg
tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc
1140agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc
ggtgctgtgc 1200caggcccacg gcttgacccc ggagcaggtg gtggccatcg
ccagcaatat tggtggcaag 1260caggcgctgg agacggtgca ggcgctgttg
ccggtgctgt gccaggccca cggcttgacc 1320ccggagcagg tggtggccat
cgccagccac gatggcggca agcaggcgct ggagacggtc 1380cagcggctgt
tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc
1440atcgccagcc acgatggcgg caagcaggcg ctggagacgg tccagcggct
gttgccggtg 1500ctgtgccagg cccacggctt gaccccggag caggtggtgg
ccatcgccag caatattggt 1560ggcaagcagg cgctggagac ggtgcaggcg
ctgttgccgg tgctgtgcca ggcccacggc 1620ttgaccccgg agcaggtggt
ggccatcgcc agccacgatg gcggcaagca ggcgctggag 1680acggtccagc
ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg
1740gtggccatcg ccagcaatat tggtggcaag caggcgctgg agacggtgca
ggcgctgttg 1800ccggtgctgt gccaggccca cggcttgacc ccccagcagg
tggtggccat cgccagcaat 1860aatggtggca agcaggcgct ggagacggtc
cagcggctgt tgccggtgct gtgccaggcc 1920cacggcttga ccccggagca
ggtggtggcc atcgccagcc acgatggcgg caagcaggcg 1980ctggagacgg
tccagcggct gttgccggtg ctgtgccagg cccacggctt gacccctcag
2040caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag
cattgttgcc 2100cagttatctc gccctgatcc ggcgttggcc gcgttgacca
acgaccacct cgtcgccttg 2160gcctgcctcg gcgggcgtcc tgcgctggat
gcagtgaaaa agggattggg ggatcctatc 2220agccgttccc agctggtgaa
gtccgagctg gaggagaaga aatccgagtt gaggcacaag 2280ctgaagtacg
tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag
2340gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg
ctacaggggc 2400aagcacctgg gcggctccag gaagcccgac ggcgccatct
acaccgtggg ctcccccatc 2460gactacggcg tgatcgtgga caccaaggcc
tactccggcg gctacaacct gcccatcggc 2520caggccgacg aaatgcagag
gtacgtggag gagaaccaga ccaggaacaa gcacatcaac 2580cccaacgagt
ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg
2640tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca
catcaccaac 2700tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg
gcggcgagat gatcaaggcc 2760ggcaccctga ccctggagga ggtgaggagg
aagttcaaca acggcgagat caacttcgcg 2820gccgactgat aa
2832932814DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotideCTLA4_T04-L TALEN 93atgggcgatc ctaaaaagaa
acgtaaggtc atcgattacc catacgatgt tccagattac 60gctatcgata tcgccgatct
acgcacgctc ggctacagcc agcagcaaca ggagaagatc 120aaaccgaagg
ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt
180acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac
cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca gaggcgacac
acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc acgcgctctg
gaggccttgc tcacggtggc gggagagttg 360agaggtccac cgttacagtt
ggacacaggc caacttctca agattgcaaa acgtggcggc 420gtgaccgcag
tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac
480ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca
ggcgctggag 540acggtccagc ggctgttgcc ggtgctgtgc caggcccacg
gcttgacccc ggagcaggtg 600gtggccatcg ccagccacga tggcggcaag
caggcgctgg agacggtcca gcggctgttg 660ccggtgctgt gccaggccca
cggcttgacc ccggagcagg tggtggccat cgccagcaat 720attggtggca
agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc
780cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg
caagcaggcg 840ctggagacgg tccagcggct gttgccggtg ctgtgccagg
cccacggctt gaccccccag 900caggtggtgg ccatcgccag caataatggt
ggcaagcagg cgctggagac ggtccagcgg 960ctgttgccgg tgctgtgcca
ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc 1020agccacgatg
gcggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc
1080caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaatgg
cggtggcaag 1140caggcgctgg agacggtcca gcggctgttg ccggtgctgt
gccaggccca cggcttgacc 1200ccggagcagg tggtggccat cgccagcaat
attggtggca agcaggcgct ggagacggtg 1260caggcgctgt tgccggtgct
gtgccaggcc cacggcttga ccccccagca ggtggtggcc 1320atcgccagca
ataatggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg
1380ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag
ccacgatggc 1440ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 1500ttgaccccgg agcaggtggt ggccatcgcc
agcaatattg gtggcaagca ggcgctggag 1560acggtgcagg cgctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg 1620gtggccatcg
ccagcaatat tggtggcaag caggcgctgg agacggtgca ggcgctgttg
1680ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat
cgccagcaat 1740ggcggtggca agcaggcgct ggagacggtc cagcggctgt
tgccggtgct gtgccaggcc 1800cacggcttga ccccccagca ggtggtggcc
atcgccagca ataatggtgg caagcaggcg 1860ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccggag 1920caggtggtgg
ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg
1980ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt
ggccatcgcc 2040agcaatggcg gcggcaggcc ggcgctggag agcattgttg
cccagttatc tcgccctgat 2100ccggcgttgg ccgcgttgac caacgaccac
ctcgtcgcct tggcctgcct cggcgggcgt 2160cctgcgctgg atgcagtgaa
aaagggattg ggggatccta tcagccgttc ccagctggtg 2220aagtccgagc
tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac
2280gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat
cctggagatg 2340aaggtgatgg agttcttcat gaaggtgtac ggctacaggg
gcaagcacct gggcggctcc 2400aggaagcccg acggcgccat ctacaccgtg
ggctccccca tcgactacgg cgtgatcgtg 2460gacaccaagg cctactccgg
cggctacaac ctgcccatcg gccaggccga cgaaatgcag 2520aggtacgtgg
aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag
2580gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca
cttcaagggc 2640aactacaagg cccagctgac caggctgaac cacatcacca
actgcaacgg cgccgtgctg 2700tccgtggagg agctcctgat cggcggcgag
atgatcaagg ccggcaccct gaccctggag 2760gaggtgagga ggaagttcaa
caacggcgag atcaacttcg cggccgactg ataa 2814942832DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
polynucleotideCTLA4_T04-R TALEN 94atgggcgatc ctaaaaagaa acgtaaggtc
atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag catcgatatc
gccgatctac gcacgctcgg ctacagccag 120cagcaacagg agaagatcaa
accgaaggtt cgttcgacag tggcgcagca ccacgaggca 180ctggtcggcc
acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg
240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga
ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac
gcgctctgga ggccttgctc 360acggtggcgg gagagttgag aggtccaccg
ttacagttgg acacaggcca acttctcaag 420attgcaaaac gtggcggcgt
gaccgcagtg gaggcagtgc atgcatggcg caatgcactg 480acgggtgccc
cgctcaactt gaccccccag caggtggtgg ccatcgccag caataatggt
540ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca
ggcccacggc 600ttgaccccgg agcaggtggt ggccatcgcc agccacgatg
gcggcaagca ggcgctggag 660acggtccagc ggctgttgcc ggtgctgtgc
caggcccacg gcttgacccc ccagcaggtg 720gtggccatcg ccagcaatgg
cggtggcaag caggcgctgg agacggtcca gcggctgttg 780ccggtgctgt
gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat
840aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct
gtgccaggcc 900cacggcttga ccccccagca ggtggtggcc atcgccagca
ataatggtgg caagcaggcg 960ctggagacgg tccagcggct gttgccggtg
ctgtgccagg cccacggctt gaccccggag 1020caggtggtgg ccatcgccag
ccacgatggc ggcaagcagg cgctggagac ggtccagcgg 1080ctgttgccgg
tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc
1140agccacgatg gcggcaagca ggcgctggag acggtccagc ggctgttgcc
ggtgctgtgc 1200caggcccacg gcttgacccc ggagcaggtg gtggccatcg
ccagcaatat tggtggcaag 1260caggcgctgg agacggtgca ggcgctgttg
ccggtgctgt gccaggccca cggcttgacc 1320ccccagcagg tggtggccat
cgccagcaat aatggtggca agcaggcgct ggagacggtc 1380cagcggctgt
tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc
1440atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct
gttgccggtg 1500ctgtgccagg cccacggctt gaccccggag caggtggtgg
ccatcgccag caatattggt 1560ggcaagcagg cgctggagac ggtgcaggcg
ctgttgccgg tgctgtgcca ggcccacggc 1620ttgaccccgg agcaggtggt
ggccatcgcc agccacgatg gcggcaagca ggcgctggag 1680acggtccagc
ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg
1740gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca
gcggctgttg 1800ccggtgctgt gccaggccca cggcttgacc ccggagcagg
tggtggccat cgccagcaat 1860attggtggca agcaggcgct ggagacggtg
caggcgctgt tgccggtgct gtgccaggcc 1920cacggcttga ccccggagca
ggtggtggcc atcgccagcc acgatggcgg caagcaggcg 1980ctggagacgg
tccagcggct gttgccggtg ctgtgccagg cccacggctt gacccctcag
2040caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag
cattgttgcc 2100cagttatctc gccctgatcc ggcgttggcc gcgttgacca
acgaccacct cgtcgccttg 2160gcctgcctcg gcgggcgtcc tgcgctggat
gcagtgaaaa agggattggg ggatcctatc 2220agccgttccc agctggtgaa
gtccgagctg gaggagaaga aatccgagtt gaggcacaag 2280ctgaagtacg
tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag
2340gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg
ctacaggggc 2400aagcacctgg gcggctccag gaagcccgac ggcgccatct
acaccgtggg ctcccccatc 2460gactacggcg tgatcgtgga caccaaggcc
tactccggcg gctacaacct gcccatcggc 2520caggccgacg aaatgcagag
gtacgtggag gagaaccaga ccaggaacaa gcacatcaac 2580cccaacgagt
ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg
2640tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca
catcaccaac 2700tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg
gcggcgagat gatcaaggcc 2760ggcaccctga ccctggagga ggtgaggagg
aagttcaaca acggcgagat caacttcgcg 2820gccgactgat aa
2832952814DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotidePDCD1_T01-L TALEN 95atgggcgatc ctaaaaagaa
acgtaaggtc atcgattacc catacgatgt tccagattac 60gctatcgata tcgccgatct
acgcacgctc ggctacagcc agcagcaaca ggagaagatc 120aaaccgaagg
ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt
180acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac
cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca gaggcgacac
acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc acgcgctctg
gaggccttgc tcacggtggc gggagagttg 360agaggtccac cgttacagtt
ggacacaggc caacttctca agattgcaaa acgtggcggc 420gtgaccgcag
tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac
480ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca
ggcgctggag 540acggtccagc ggctgttgcc ggtgctgtgc caggcccacg
gcttgacccc ggagcaggtg 600gtggccatcg ccagccacga tggcggcaag
caggcgctgg agacggtcca gcggctgttg 660ccggtgctgt gccaggccca
cggcttgacc ccccagcagg tggtggccat cgccagcaat 720ggcggtggca
agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc
780cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg
caagcaggcg 840ctggagacgg tccagcggct gttgccggtg ctgtgccagg
cccacggctt gaccccggag 900caggtggtgg ccatcgccag ccacgatggc
ggcaagcagg cgctggagac ggtccagcgg 960ctgttgccgg tgctgtgcca
ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc 1020agccacgatg
gcggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc
1080caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagccacga
tggcggcaag 1140caggcgctgg agacggtcca gcggctgttg ccggtgctgt
gccaggccca cggcttgacc 1200ccggagcagg tggtggccat cgccagcaat
attggtggca agcaggcgct ggagacggtg 1260caggcgctgt tgccggtgct
gtgccaggcc cacggcttga ccccccagca ggtggtggcc 1320atcgccagca
ataatggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg
1380ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag
ccacgatggc 1440ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 1500ttgaccccgg agcaggtggt ggccatcgcc
agccacgatg gcggcaagca ggcgctggag 1560acggtccagc ggctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg 1620gtggccatcg
ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg
1680ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat
cgccagcaat 1740ggcggtggca agcaggcgct ggagacggtc cagcggctgt
tgccggtgct gtgccaggcc 1800cacggcttga ccccccagca ggtggtggcc
atcgccagca ataatggtgg caagcaggcg 1860ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccggag 1920caggtggtgg
ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg
1980ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt
ggccatcgcc 2040agcaatggcg gcggcaggcc ggcgctggag agcattgttg
cccagttatc tcgccctgat 2100ccggcgttgg ccgcgttgac caacgaccac
ctcgtcgcct tggcctgcct cggcgggcgt 2160cctgcgctgg atgcagtgaa
aaagggattg ggggatccta tcagccgttc ccagctggtg 2220aagtccgagc
tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac
2280gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat
cctggagatg 2340aaggtgatgg agttcttcat gaaggtgtac ggctacaggg
gcaagcacct gggcggctcc 2400aggaagcccg acggcgccat ctacaccgtg
ggctccccca tcgactacgg cgtgatcgtg 2460gacaccaagg cctactccgg
cggctacaac ctgcccatcg gccaggccga cgaaatgcag 2520aggtacgtgg
aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag
2580gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca
cttcaagggc 2640aactacaagg cccagctgac caggctgaac cacatcacca
actgcaacgg cgccgtgctg 2700tccgtggagg agctcctgat cggcggcgag
atgatcaagg ccggcaccct gaccctggag 2760gaggtgagga ggaagttcaa
caacggcgag atcaacttcg cggccgactg ataa 2814962829DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
polynucleotidePDCD1_T01-R TALEN 96atgggcgatc ctaaaaagaa acgtaaggtc
atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag catcgatatc
gccgatctac gcacgctcgg ctacagccag 120cagcaacagg agaagatcaa
accgaaggtt cgttcgacag tggcgcagca ccacgaggca 180ctggtcggcc
acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg
240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga
ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac
gcgctctgga ggccttgctc 360acggtggcgg gagagttgag aggtccaccg
ttacagttgg acacaggcca acttctcaag 420attgcaaaac gtggcggcgt
gaccgcagtg gaggcagtgc atgcatggcg caatgcactg 480acgggtgccc
cgctcaactt gaccccccag caagtcgtcg caatcgccag caataacgga
540gggaagcaag ccctcgaaac cgtgcagcgg ttgcttcctg tgctctgcca
ggcccacggc 600cttacccctg agcaggtggt ggccatcgca agtaacattg
gaggaaagca agccttggag 660acagtgcagg ccctgttgcc cgtgctgtgc
caggcacacg gcctcacacc agagcaggtc 720gtggccattg cctccaacat
cggggggaaa caggctctgg agaccgtcca ggccctgctg 780cccgtcctct
gtcaagctca cggcctgact ccccaacaag tggtcgccat cgcctctaat
840aacggcggga agcaggcact ggaaacagtg cagagactgc tccctgtgct
ttgccaagct 900catgggttga ccccccaaca ggtcgtcgct attgcctcaa
acaacggggg caagcaggcc 960cttgagactg tgcagaggct gttgccagtg
ctgtgtcagg ctcacgggct cactccacaa 1020caggtggtcg caattgccag
caacggcggc ggaaagcaag ctcttgaaac cgtgcaacgc 1080ctcctgcccg
tgctctgtca ggctcatggc ctgacaccac aacaagtcgt ggccatcgcc
1140agtaataatg gcgggaaaca ggctcttgag accgtccaga ggctgctccc
agtgctctgc 1200caggcacacg ggctgacccc ccagcaggtg gtggctatcg
ccagcaataa tgggggcaag 1260caggccctgg aaacagtcca gcgcctgctg
ccagtgcttt gccaggctca cgggctcact 1320cccgaacagg tcgtggcaat
cgcctccaac ggagggaagc aggctctgga gaccgtgcag 1380agactgctgc
ccgtcttgtg ccaggcccac ggactcacac ctcagcaggt cgtcgccatt
1440gcctctaaca acgggggcaa acaagccctg gagacagtgc agcggctgtt
gcctgtgttg 1500tgccaagccc acggcttgac tcctcaacaa gtggtcgcca
tcgcctcaaa tggcggcgga 1560aaacaagctc tggagacagt gcagaggttg
ctgcccgtcc tctgccaagc ccacggcctg 1620actccccaac aggtcgtcgc
cattgccagc aacggcggag gaaagcaggc tctcgaaact 1680gtgcagcggc
tgcttcctgt gctgtgtcag gctcatgggc tgacccccca gcaagtggtg
1740gctattgcct ctaacaatgg aggcaagcaa gcccttgaga cagtccagag
gctgttgcca 1800gtgctgtgcc aggcccacgg gctcacaccc cagcaggtgg
tcgccatcgc cagtaacggc 1860gggggcaaac aggcattgga aaccgtccag
cgcctgcttc cagtgctctg ccaggcacac 1920ggactgacac ccgaacaggt
ggtggccatt gcatcccatg atgggggcaa gcaggccctg 1980gagaccgtgc
agagactcct gccagtgttg tgccaagctc acggcctcac ccctcagcaa
2040gtcgtggcca tcgcctcaaa cggggggggc cggcctgcac tggagagcat
tgttgcccag 2100ttatctcgcc ctgatccggc gttggccgcg ttgaccaacg
accacctcgt cgccttggcc 2160tgcctcggcg ggcgtcctgc gctggatgca
gtgaaaaagg gattggggga tcctatcagc 2220cgttcccagc tggtgaagtc
cgagctggag gagaagaaat ccgagttgag gcacaagctg 2280aagtacgtgc
cccacgagta catcgagctg atcgagatcg cccggaacag cacccaggac
2340cgtatcctgg agatgaaggt gatggagttc ttcatgaagg tgtacggcta
caggggcaag 2400cacctgggcg gctccaggaa gcccgacggc gccatctaca
ccgtgggctc ccccatcgac 2460tacggcgtga tcgtggacac caaggcctac
tccggcggct acaacctgcc catcggccag 2520gccgacgaaa tgcagaggta
cgtggaggag aaccagacca ggaacaagca catcaacccc 2580aacgagtggt
ggaaggtgta cccctccagc gtgaccgagt tcaagttcct gttcgtgtcc
2640ggccacttca agggcaacta caaggcccag ctgaccaggc tgaaccacat
caccaactgc 2700aacggcgccg tgctgtccgt ggaggagctc ctgatcggcg
gcgagatgat caaggccggc 2760accctgaccc tggaggaggt gaggaggaag
ttcaacaacg gcgagatcaa cttcgcggcc 2820gactgataa
2829972814DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotidePDCD1_T03-L TALEN 97atgggcgatc ctaaaaagaa
acgtaaggtc atcgattacc catacgatgt tccagattac 60gctatcgata tcgccgatct
acgcacgctc ggctacagcc agcagcaaca ggagaagatc 120aaaccgaagg
ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt
180acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac
cgtcgctgtc 240aagtatcagg acatgatcgc agcgttgcca gaggcgacac
acgaagcgat cgttggcgtc 300ggcaaacagt ggtccggcgc acgcgctctg
gaggccttgc tcacggtggc gggagagttg 360agaggtccac cgttacagtt
ggacacaggc caacttctca agattgcaaa acgtggcggc 420gtgaccgcag
tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac
480ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca
ggcgctggag 540acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg
gcttgacccc ggagcaggtg 600gtggccatcg ccagccacga tggcggcaag
caggcgctgg agacggtcca gcggctgttg 660ccggtgctgt gccaggccca
cggcttgacc ccggagcagg tggtggccat cgccagccac 720gatggcggca
agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc
780cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg
caagcaggcg 840ctggagacgg tccagcggct gttgccggtg ctgtgccagg
cccacggctt gaccccggag 900caggtggtgg ccatcgccag ccacgatggc
ggcaagcagg cgctggagac ggtccagcgg 960ctgttgccgg tgctgtgcca
ggcccacggc ttgacccccc agcaggtggt ggccatcgcc 1020agcaatggcg
gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc
1080caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaataa
tggtggcaag 1140caggcgctgg agacggtcca gcggctgttg ccggtgctgt
gccaggccca cggcttgacc 1200ccccagcagg tggtggccat cgccagcaat
ggcggtggca agcaggcgct ggagacggtc 1260cagcggctgt tgccggtgct
gtgccaggcc cacggcttga ccccccagca ggtggtggcc 1320atcgccagca
ataatggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg
1380ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag
caataatggt 1440ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg
tgctgtgcca ggcccacggc 1500ttgacccccc agcaggtggt ggccatcgcc
agcaataatg gtggcaagca ggcgctggag 1560acggtccagc ggctgttgcc
ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg 1620gtggccatcg
ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg
1680ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat
cgccagccac 1740gatggcggca agcaggcgct ggagacggtc cagcggctgt
tgccggtgct gtgccaggcc 1800cacggcttga ccccggagca ggtggtggcc
atcgccagcc acgatggcgg caagcaggcg 1860ctggagacgg tccagcggct
gttgccggtg ctgtgccagg cccacggctt gaccccggag 1920caggtggtgg
ccatcgccag caatattggt ggcaagcagg cgctggagac ggtgcaggcg
1980ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt
ggccatcgcc 2040agcaatggcg gcggcaggcc ggcgctggag agcattgttg
cccagttatc tcgccctgat 2100ccggcgttgg ccgcgttgac caacgaccac
ctcgtcgcct tggcctgcct cggcgggcgt 2160cctgcgctgg atgcagtgaa
aaagggattg ggggatccta tcagccgttc ccagctggtg 2220aagtccgagc
tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac
2280gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat
cctggagatg 2340aaggtgatgg agttcttcat gaaggtgtac ggctacaggg
gcaagcacct gggcggctcc 2400aggaagcccg acggcgccat ctacaccgtg
ggctccccca tcgactacgg cgtgatcgtg 2460gacaccaagg cctactccgg
cggctacaac ctgcccatcg gccaggccga cgaaatgcag 2520aggtacgtgg
aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag
2580gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca
cttcaagggc 2640aactacaagg cccagctgac caggctgaac cacatcacca
actgcaacgg cgccgtgctg 2700tccgtggagg agctcctgat cggcggcgag
atgatcaagg ccggcaccct gaccctggag 2760gaggtgagga ggaagttcaa
caacggcgag atcaacttcg cggccgactg ataa 2814982829DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
polynucleotidePDCD1_T03-R TALEN 98atgggcgatc ctaaaaagaa acgtaaggtc
atcgataagg agaccgccgc tgccaagttc 60gagagacagc acatggacag catcgatatc
gccgatctac gcacgctcgg ctacagccag 120cagcaacagg agaagatcaa
accgaaggtt cgttcgacag tggcgcagca ccacgaggca 180ctggtcggcc
acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg
240ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga
ggcgacacac 300gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac
gcgctctgga ggccttgctc 360acggtggcgg gagagttgag aggtccaccg
ttacagttgg acacaggcca acttctcaag 420attgcaaaac gtggcggcgt
gaccgcagtg gaggcagtgc atgcatggcg caatgcactg 480acgggtgccc
cgctcaactt gacccccgag caagtcgtcg caatcgccag ccatgatgga
540gggaagcaag ccctcgaaac cgtgcagcgg ttgcttcctg tgctctgcca
ggcccacggc 600cttacccctc agcaggtggt ggccatcgca agtaacggag
gaggaaagca agccttggag 660acagtgcagc gcctgttgcc cgtgctgtgc
caggcacacg gcctcacacc agagcaggtc 720gtggccattg cctcccatga
cggggggaaa caggctctgg agaccgtcca gaggctgctg 780cccgtcctct
gtcaagctca cggcctgact ccccaacaag tggtcgccat cgcctctaat
840ggcggcggga agcaggcact ggaaacagtg cagagactgc tccctgtgct
ttgccaagct 900catgggttga ccccccaaca ggtcgtcgct attgcctcaa
acgggggggg caagcaggcc 960cttgagactg tgcagaggct gttgccagtg
ctgtgtcagg ctcacgggct cactccacaa 1020caggtggtcg caattgccag
caacggcggc ggaaagcaag ctcttgaaac cgtgcaacgc 1080ctcctgcccg
tgctctgtca ggctcatggc ctgacaccac aacaagtcgt ggccatcgcc
1140agtaataatg gcgggaaaca ggctcttgag accgtccaga ggctgctccc
agtgctctgc 1200caggcacacg ggctgacccc cgagcaggtg gtggctatcg
ccagcaatat tgggggcaag 1260caggccctgg aaacagtcca ggccctgctg
ccagtgcttt gccaggctca cgggctcact 1320ccccagcagg tcgtggcaat
cgcctccaac ggcggaggga agcaggctct ggagaccgtg 1380cagagactgc
tgcccgtctt gtgccaggcc cacggactca cacctgaaca ggtcgtcgcc
1440attgcctctc acgatggggg caaacaagcc ctggagacag tgcagcggct
gttgcctgtg 1500ttgtgccaag cccacggctt gactcctcaa caagtggtcg
ccatcgcctc aaatggcggc 1560ggaaaacaag ctctggagac agtgcagagg
ttgctgcccg tcctctgcca agcccacggc 1620ctgactcccc aacaggtcgt
cgccattgcc agcaacaacg gaggaaagca ggctctcgaa 1680actgtgcagc
ggctgcttcc tgtgctgtgt caggctcatg ggctgacccc cgagcaagtg
1740gtggctattg cctctaatgg aggcaagcaa gcccttgaga cagtccagag
gctgttgcca 1800gtgctgtgcc aggcccacgg gctcacaccc cagcaggtgg
tcgccatcgc cagtaacaac 1860gggggcaaac aggcattgga aaccgtccag
cgcctgcttc cagtgctctg ccaggcacac 1920ggactgacac ccgaacaggt
ggtggccatt gcatcccatg atgggggcaa gcaggccctg 1980gagaccgtgc
agagactcct gccagtgttg tgccaagctc acggcctcac ccctcagcaa
2040gtcgtggcca tcgcctcaaa cggggggggc cggcctgcac tggagagcat
tgttgcccag 2100ttatctcgcc ctgatccggc gttggccgcg ttgaccaacg
accacctcgt cgccttggcc 2160tgcctcggcg ggcgtcctgc gctggatgca
gtgaaaaagg gattggggga tcctatcagc 2220cgttcccagc tggtgaagtc
cgagctggag gagaagaaat ccgagttgag gcacaagctg 2280aagtacgtgc
cccacgagta catcgagctg atcgagatcg cccggaacag cacccaggac
2340cgtatcctgg agatgaaggt gatggagttc ttcatgaagg tgtacggcta
caggggcaag 2400cacctgggcg gctccaggaa gcccgacggc gccatctaca
ccgtgggctc ccccatcgac 2460tacggcgtga tcgtggacac caaggcctac
tccggcggct acaacctgcc catcggccag 2520gccgacgaaa tgcagaggta
cgtggaggag aaccagacca ggaacaagca catcaacccc 2580aacgagtggt
ggaaggtgta cccctccagc gtgaccgagt tcaagttcct gttcgtgtcc
2640ggccacttca agggcaacta caaggcccag ctgaccaggc tgaaccacat
caccaactgc 2700aacggcgccg tgctgtccgt ggaggagctc ctgatcggcg
gcgagatgat caaggccggc 2760accctgaccc tggaggaggt gaggaggaag
ttcaacaacg gcgagatcaa cttcgcggcc 2820gactgataa
28299960DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideForward composite primer for CTLA4_T01,
including SEQ ID NO 128, 10N tag, and SEQ ID NO
143modified_base(31)..(40)a, c, t or g 99ccatctcatc cctgcgtgtc
tccgactcag nnnnnnnnnn ctctacttcc tgaagacctg 6010060DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideForward composite primer for CTLA4_T03/T04,
including SEQ ID NO 128, 10N tag, and SEQ ID NO
144modified_base(31)..(40)a, c, t or g 100ccatctcatc cctgcgtgtc
tccgactcag nnnnnnnnnn acagttgaga gatggagggg 6010159DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideForward composite primer for PDCD1_T01, including
SEQ ID NO 128, 10N tag, and SEQ ID NO 145modified_base(31)..(40)a,
c, t or g 101ccatctcatc cctgcgtgtc tccgactcag nnnnnnnnnn ccacagaggt
aggtgccgc 5910260DNAArtificial SequenceDescription of Artificial
Sequence Synthetic oligonucleotideForward composite primer for
PDCD1_T03, including SEQ ID NO 128, 10N tag, and SEQ ID NO
146modified_base(31)..(40)a, c, t or g 102ccatctcatc cctgcgtgtc
tccgactcag nnnnnnnnnn gacagagatg ccggtcacca 6010350DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideReverse composite primer for CTLA4_T01, including
SEQ ID NO 132 and SEQ ID NO 147 103cctatcccct gtgtgccttg gcagtctcag
tggaatacag agccagccaa 5010450DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotideReverse composite
primer for CTLA4_T03/T04, including SEQ ID NO 132 and SEQ ID NO 148
104cctatcccct gtgtgccttg gcagtctcag ggtgcccgtg cagatggaat
5010550DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideReverse composite primer for PDCD1_T01,
including SEQ ID NO 132 and SEQ ID NO 149 105cctatcccct gtgtgccttg
gcagtctcag ggctctgcag tggaggccag 5010650DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideReverse composite primer for PDCD1_T03, including
SEQ ID NO 132 and SEQ ID NO 150 106cctatcccct gtgtgccttg gcagtctcag
ggacaacgcc accttcacct 50107281PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptidepTalpha-FL 107Met Ala Gly
Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15 Leu
Pro Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20 25
30 Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu
35 40 45 Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp
Phe Ser 50 55 60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr
Gly Pro Ser Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala
His Leu Ser Leu Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu Pro
Leu Val Cys His Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser Arg
Ser Thr Gln Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr Ala
Arg Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly Gly
Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150 155
160 Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro Ala
165 170 175 Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg Ala
Leu Gly 180 185 190 Ser His Arg Leu His Pro Ala Thr Glu Thr Gly Gly
Arg Glu Ala Thr 195 200 205 Ser Ser Pro Arg Pro Gln Pro Arg Asp Arg
Arg Trp Gly Asp Thr Pro 210 215 220 Pro Gly Arg Lys Pro Gly Ser Pro
Val Trp Gly Glu Gly Ser Tyr Leu 225 230 235 240 Ser Ser Tyr Pro Thr
Cys Pro Ala Gln Ala Trp Cys Ser Arg Ser Arg 245 250 255 Leu Arg Ala
Pro Ser Ser Ser Leu Gly Ala Phe Phe Arg Gly Asp Leu 260 265 270 Pro
Pro Pro Leu Gln Ala Gly Ala Ala 275 280 108263PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptidepTalpha-Delta18 108Met Ala Gly Thr Trp Leu Leu Leu Leu
Leu Ala Leu Gly Cys Pro Ala 1 5 10 15 Leu Pro Thr Gly Val Gly Gly
Thr Pro Phe Pro Ser Leu Ala Pro Pro 20 25 30 Ile Met Leu Leu Val
Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 35 40 45 Val Leu Asp
Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe Ser 50 55 60 Ala
Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly Pro Ser Pro 65 70
75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His Leu Ser Leu Pro
Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu Pro Leu Val Cys His Thr
Gly Pro Gly 100 105 110 Ala Glu Gly His Ser Arg Ser
Thr Gln Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr Ala Arg
Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly Gly Ala
Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150 155 160
Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro Ala 165
170 175 Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg Ala Leu
Gly 180 185 190 Ser His Arg Leu His Pro Ala Thr Glu Thr Gly Gly Arg
Glu Ala Thr 195 200 205 Ser Ser Pro Arg Pro Gln Pro Arg Asp Arg Arg
Trp Gly Asp Thr Pro 210 215 220 Pro Gly Arg Lys Pro Gly Ser Pro Val
Trp Gly Glu Gly Ser Tyr Leu 225 230 235 240 Ser Ser Tyr Pro Thr Cys
Pro Ala Gln Ala Trp Cys Ser Arg Ser Arg 245 250 255 Leu Arg Ala Pro
Ser Ser Ser 260 109233PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptidepTalpha-Delta48 109Met Ala
Gly Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15
Leu Pro Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20
25 30 Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys
Leu 35 40 45 Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile
Trp Phe Ser 50 55 60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr
Tyr Gly Pro Ser Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu
Ala His Leu Ser Leu Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu
Pro Leu Val Cys His Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser
Arg Ser Thr Gln Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr
Ala Arg Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly
Gly Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150
155 160 Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro
Ala 165 170 175 Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg
Ala Leu Gly 180 185 190 Ser His Arg Leu His Pro Ala Thr Glu Thr Gly
Gly Arg Glu Ala Thr 195 200 205 Ser Ser Pro Arg Pro Gln Pro Arg Asp
Arg Arg Trp Gly Asp Thr Pro 210 215 220 Pro Gly Arg Lys Pro Gly Ser
Pro Val 225 230 110219PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptidepTalpha-Delta62 110Met Ala
Gly Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15
Leu Pro Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20
25 30 Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys
Leu 35 40 45 Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile
Trp Phe Ser 50 55 60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr
Tyr Gly Pro Ser Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu
Ala His Leu Ser Leu Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu
Pro Leu Val Cys His Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser
Arg Ser Thr Gln Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr
Ala Arg Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly
Gly Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150
155 160 Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro
Ala 165 170 175 Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg
Ala Leu Gly 180 185 190 Ser His Arg Leu His Pro Ala Thr Glu Thr Gly
Gly Arg Glu Ala Thr 195 200 205 Ser Ser Pro Arg Pro Gln Pro Arg Asp
Arg Arg 210 215 111203PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptidepTalpha-Delta78 111Met Ala
Gly Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15
Leu Pro Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20
25 30 Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys
Leu 35 40 45 Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile
Trp Phe Ser 50 55 60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr
Tyr Gly Pro Ser Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu
Ala His Leu Ser Leu Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu
Pro Leu Val Cys His Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser
Arg Ser Thr Gln Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr
Ala Arg Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly
Gly Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150
155 160 Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro
Ala 165 170 175 Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg
Ala Leu Gly 180 185 190 Ser His Arg Leu His Pro Ala Thr Glu Thr Gly
195 200 112189PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptidepTalpha-Delta92 112Met Ala Gly Thr
Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15 Leu Pro
Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20 25 30
Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 35
40 45 Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe
Ser 50 55 60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly
Pro Ser Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His
Leu Ser Leu Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu Pro Leu
Val Cys His Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser Arg Ser
Thr Gln Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr Ala Arg
Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly Gly Ala
Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150 155 160
Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro Ala 165
170 175 Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg 180 185
113171PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptidepTalpha-Delta110 113Met Ala Gly Thr Trp Leu
Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15 Leu Pro Thr Gly
Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20 25 30 Ile Met
Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 35 40 45
Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe Ser 50
55 60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly Pro Ser
Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His Leu Ser
Leu Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu Pro Leu Val Cys
His Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser Arg Ser Thr Gln
Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr Ala Arg Thr Cys
Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly Gly Ala Leu Trp
Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150 155 160 Leu Leu
Phe Asp Leu Leu Leu Thr Cys Ser Cys 165 170 114167PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptidepTalpha-Delta114 114Met Ala Gly Thr Trp Leu Leu Leu Leu
Leu Ala Leu Gly Cys Pro Ala 1 5 10 15 Leu Pro Thr Gly Val Gly Gly
Thr Pro Phe Pro Ser Leu Ala Pro Pro 20 25 30 Ile Met Leu Leu Val
Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 35 40 45 Val Leu Asp
Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe Ser 50 55 60 Ala
Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly Pro Ser Pro 65 70
75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His Leu Ser Leu Pro
Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu Pro Leu Val Cys His Thr
Gly Pro Gly 100 105 110 Ala Glu Gly His Ser Arg Ser Thr Gln Pro Met
His Leu Ser Gly Glu 115 120 125 Ala Ser Thr Ala Arg Thr Cys Pro Gln
Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly Gly Ala Leu Trp Leu Gly
Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150 155 160 Leu Leu Phe Asp
Leu Leu Leu 165 115344PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptidepTalpha-FL-CD28 115Met Ala
Gly Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15
Leu Pro Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20
25 30 Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys
Leu 35 40 45 Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile
Trp Phe Ser 50 55 60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr
Tyr Gly Pro Ser Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu
Ala His Leu Ser Leu Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu
Pro Leu Val Cys His Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser
Arg Ser Thr Gln Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr
Ala Arg Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly
Gly Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150
155 160 Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro
Ala 165 170 175 Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg
Ala Leu Gly 180 185 190 Ser His Arg Leu His Pro Ala Thr Glu Thr Gly
Gly Arg Glu Ala Thr 195 200 205 Ser Ser Pro Arg Pro Gln Pro Arg Asp
Arg Arg Trp Gly Asp Thr Pro 210 215 220 Pro Gly Arg Lys Pro Gly Ser
Pro Val Trp Gly Glu Gly Ser Tyr Leu 225 230 235 240 Ser Ser Tyr Pro
Thr Cys Pro Ala Gln Ala Trp Cys Ser Arg Ser Arg 245 250 255 Leu Arg
Ala Pro Ser Ser Ser Leu Gly Ala Phe Phe Arg Gly Asp Leu 260 265 270
Pro Pro Pro Leu Gln Ala Gly Ala Ala Ala Ser Gly Gly Val Leu Ala 275
280 285 Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
Arg 290 295 300 Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn
Met Thr Pro 305 310 315 320 Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
Gln Pro Tyr Ala Pro Pro 325 330 335 Arg Asp Phe Ala Ala Tyr Arg Ser
340 116311PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptidepTalpha-FL-CD8 116Met Ala Gly Thr Trp Leu Leu
Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15 Leu Pro Thr Gly Val
Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20 25 30 Ile Met Leu
Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 35 40 45 Val
Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe Ser 50 55
60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly Pro Ser Pro
65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His Leu Ser Leu
Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu Pro Leu Val Cys His
Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser Arg Ser Thr Gln Pro
Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr Ala Arg Thr Cys Pro
Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly Gly Ala Leu Trp Leu
Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150 155 160 Leu Leu Phe
Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro Ala 165 170 175 Gly
Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg Ala Leu Gly 180 185
190 Ser His Arg Leu His Pro Ala Thr Glu Thr Gly Gly Arg Glu Ala Thr
195 200 205 Ser Ser Pro Arg Pro Gln Pro Arg Asp Arg Arg Trp Gly Asp
Thr Pro 210 215 220 Pro Gly Arg Lys Pro Gly Ser Pro Val Trp Gly Glu
Gly Ser Tyr Leu 225 230 235 240 Ser Ser Tyr Pro Thr Cys Pro Ala Gln
Ala Trp Cys Ser Arg Ser Arg 245 250 255 Leu Arg Ala Pro Ser Ser Ser
Leu Gly Ala Phe Phe Arg Gly Asp Leu 260 265 270 Pro Pro Pro Leu Gln
Ala Gly Ala Ala Ala Ser His Arg Asn Arg Arg 275 280 285 Arg Val Cys
Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro 290 295 300 Ser
Leu Ser Ala Arg Tyr Val 305 310 117325PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptidepTalpha-FL-41BB 117Met Ala Gly Thr Trp Leu Leu Leu Leu
Leu Ala Leu Gly Cys Pro Ala 1 5 10 15 Leu Pro Thr Gly Val Gly Gly
Thr Pro Phe Pro Ser Leu Ala Pro Pro 20 25 30 Ile Met Leu Leu Val
Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 35 40 45 Val Leu Asp
Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe Ser 50 55 60 Ala
Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly Pro Ser Pro 65 70
75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His Leu Ser Leu Pro
Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu Pro Leu Val Cys His Thr
Gly Pro Gly 100 105 110 Ala Glu Gly His Ser Arg Ser Thr Gln Pro Met
His Leu Ser Gly Glu 115 120 125 Ala Ser Thr Ala Arg Thr Cys Pro Gln
Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly Gly Ala Leu Trp Leu Gly
Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150 155 160 Leu Leu Phe Asp
Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro Ala 165 170 175 Gly Pro
Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg Ala Leu Gly 180 185 190
Ser His
Arg Leu His Pro Ala Thr Glu Thr Gly Gly Arg Glu Ala Thr 195 200 205
Ser Ser Pro Arg Pro Gln Pro Arg Asp Arg Arg Trp Gly Asp Thr Pro 210
215 220 Pro Gly Arg Lys Pro Gly Ser Pro Val Trp Gly Glu Gly Ser Tyr
Leu 225 230 235 240 Ser Ser Tyr Pro Thr Cys Pro Ala Gln Ala Trp Cys
Ser Arg Ser Arg 245 250 255 Leu Arg Ala Pro Ser Ser Ser Leu Gly Ala
Phe Phe Arg Gly Asp Leu 260 265 270 Pro Pro Pro Leu Gln Ala Gly Ala
Ala Gly Ser Lys Arg Gly Arg Lys 275 280 285 Lys Leu Leu Tyr Ile Phe
Lys Gln Pro Phe Met Arg Pro Val Gln Thr 290 295 300 Thr Gln Glu Glu
Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 305 310 315 320 Gly
Gly Cys Glu Leu 325 118296PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptidepTalpha-Delta48-CD28
118Met Ala Gly Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala
1 5 10 15 Leu Pro Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala
Pro Pro 20 25 30 Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val
Val Val Cys Leu 35 40 45 Val Leu Asp Val Ala Pro Pro Gly Leu Asp
Ser Pro Ile Trp Phe Ser 50 55 60 Ala Gly Asn Gly Ser Ala Leu Asp
Ala Phe Thr Tyr Gly Pro Ser Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp
Thr Asn Leu Ala His Leu Ser Leu Pro Ser 85 90 95 Glu Glu Leu Ala
Ser Trp Glu Pro Leu Val Cys His Thr Gly Pro Gly 100 105 110 Ala Glu
Gly His Ser Arg Ser Thr Gln Pro Met His Leu Ser Gly Glu 115 120 125
Ala Ser Thr Ala Arg Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 130
135 140 Gly Gly Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys
Leu 145 150 155 160 Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu
Cys Asp Pro Ala 165 170 175 Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr
Arg Leu Arg Ala Leu Gly 180 185 190 Ser His Arg Leu His Pro Ala Thr
Glu Thr Gly Gly Arg Glu Ala Thr 195 200 205 Ser Ser Pro Arg Pro Gln
Pro Arg Asp Arg Arg Trp Gly Asp Thr Pro 210 215 220 Pro Gly Arg Lys
Pro Gly Ser Pro Val Ala Ser Gly Gly Val Leu Ala 225 230 235 240 Cys
Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 245 250
255 Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr Pro
260 265 270 Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
Pro Pro 275 280 285 Arg Asp Phe Ala Ala Tyr Arg Ser 290 295
119263PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptidepTalpha-Delta48-CD8 119Met Ala Gly Thr Trp Leu
Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15 Leu Pro Thr Gly
Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20 25 30 Ile Met
Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 35 40 45
Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe Ser 50
55 60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly Pro Ser
Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His Leu Ser
Leu Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu Pro Leu Val Cys
His Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser Arg Ser Thr Gln
Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr Ala Arg Thr Cys
Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly Gly Ala Leu Trp
Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150 155 160 Leu Leu
Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro Ala 165 170 175
Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg Ala Leu Gly 180
185 190 Ser His Arg Leu His Pro Ala Thr Glu Thr Gly Gly Arg Glu Ala
Thr 195 200 205 Ser Ser Pro Arg Pro Gln Pro Arg Asp Arg Arg Trp Gly
Asp Thr Pro 210 215 220 Pro Gly Arg Lys Pro Gly Ser Pro Val Ala Ser
His Arg Asn Arg Arg 225 230 235 240 Arg Val Cys Lys Cys Pro Arg Pro
Val Val Lys Ser Gly Asp Lys Pro 245 250 255 Ser Leu Ser Ala Arg Tyr
Val 260 120277PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptidepTalpha-Delta48-41BB 120Met Ala Gly
Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15 Leu
Pro Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20 25
30 Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu
35 40 45 Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp
Phe Ser 50 55 60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr
Gly Pro Ser Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala
His Leu Ser Leu Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu Pro
Leu Val Cys His Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser Arg
Ser Thr Gln Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr Ala
Arg Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly Gly
Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150 155
160 Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro Ala
165 170 175 Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg Ala
Leu Gly 180 185 190 Ser His Arg Leu His Pro Ala Thr Glu Thr Gly Gly
Arg Glu Ala Thr 195 200 205 Ser Ser Pro Arg Pro Gln Pro Arg Asp Arg
Arg Trp Gly Asp Thr Pro 210 215 220 Pro Gly Arg Lys Pro Gly Ser Pro
Val Gly Ser Lys Arg Gly Arg Lys 225 230 235 240 Lys Leu Leu Tyr Ile
Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 245 250 255 Thr Gln Glu
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 260 265 270 Gly
Gly Cys Glu Leu 275 121172PRTArtificial SequenceDescription of
Artificial Sequence Synthetic
polypeptidepTalpha-Delta114-TCRalpha.IC 121Met Ala Gly Thr Trp Leu
Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15 Leu Pro Thr Gly
Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20 25 30 Ile Met
Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 35 40 45
Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe Ser 50
55 60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly Pro Ser
Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His Leu Ser
Leu Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu Pro Leu Val Cys
His Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser Arg Ser Thr Gln
Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr Ala Arg Thr Cys
Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly Gly Ala Leu Trp
Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150 155 160 Leu Leu
Phe Asp Leu Leu Leu Arg Leu Trp Ser Ser 165 170 122173PRTArtificial
SequenceDescription of Artificial Sequence Synthetic
polypeptidepTalpha.EC-TCRalpha. TM. IC 122Met Ala Gly Thr Trp Leu
Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15 Leu Pro Thr Gly
Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20 25 30 Ile Met
Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 35 40 45
Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe Ser 50
55 60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly Pro Ser
Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His Leu Ser
Leu Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu Pro Leu Val Cys
His Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser Arg Ser Thr Gln
Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr Ala Arg Thr Cys
Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly Gly Leu Ser Val
Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 145 150 155 160 Gly Phe
Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 165 170
123233PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptidepTalpha.EC-Delta48-1xMUT 123Met Ala Gly Thr
Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15 Leu Pro
Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20 25 30
Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 35
40 45 Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Arg Phe
Ser 50 55 60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly
Pro Ser Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His
Leu Ser Leu Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu Pro Leu
Val Cys His Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser Arg Ser
Thr Gln Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr Ala Arg
Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly Gly Ala
Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150 155 160
Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro Ala 165
170 175 Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg Ala Leu
Gly 180 185 190 Ser His Arg Leu His Pro Ala Thr Glu Thr Gly Gly Arg
Glu Ala Thr 195 200 205 Ser Ser Pro Arg Pro Gln Pro Arg Asp Arg Arg
Trp Gly Asp Thr Pro 210 215 220 Pro Gly Arg Lys Pro Gly Ser Pro Val
225 230 124233PRTArtificial SequenceDescription of Artificial
Sequence Synthetic polypeptidepTalpha.EC-Delta48-4xMUT 124Met Ala
Gly Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 1 5 10 15
Leu Pro Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 20
25 30 Ile Met Leu Leu Val Ala Gly Ala Gln Gln Met Val Val Val Cys
Leu 35 40 45 Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile
Trp Phe Ser 50 55 60 Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr
Tyr Gly Pro Ser Pro 65 70 75 80 Ala Thr Asp Gly Thr Trp Thr Asn Leu
Ala His Leu Ser Leu Pro Ser 85 90 95 Glu Glu Leu Ala Ser Trp Glu
Pro Leu Val Cys His Thr Gly Pro Gly 100 105 110 Ala Glu Gly His Ser
Ala Ser Thr Gln Pro Met His Leu Ser Gly Glu 115 120 125 Ala Ser Thr
Ala Ala Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 130 135 140 Gly
Gly Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 145 150
155 160 Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro
Ala 165 170 175 Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg
Ala Leu Gly 180 185 190 Ser His Arg Leu His Pro Ala Thr Glu Thr Gly
Gly Arg Glu Ala Thr 195 200 205 Ser Ser Pro Arg Pro Gln Pro Arg Asp
Arg Arg Trp Gly Asp Thr Pro 210 215 220 Pro Gly Arg Lys Pro Gly Ser
Pro Val 225 230 125848PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptideMulti-chain CAR 125Met Ala
Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 1 5 10 15
Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 20
25 30 Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys
Lys 35 40 45 Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp
Val Lys Gln 50 55 60 Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr
Ile Asn Pro Tyr Asn 65 70 75 80 Asp Gly Thr Lys Tyr Asn Glu Lys Phe
Lys Gly Lys Ala Thr Leu Thr 85 90 95 Ser Asp Lys Ser Ser Ser Thr
Ala Tyr Met Glu Leu Ser Ser Leu Thr 100 105 110 Ser Glu Asp Ser Ala
Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 115 120 125 Gly Ser Arg
Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 130 135 140 Ser
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 145 150
155 160 Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr
Pro 165 170 175 Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser
Leu Leu Asn 180 185 190 Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu
Gln Arg Pro Gly Gln 195 200 205 Ser Pro Gln Leu Leu Ile Tyr Arg Met
Ser Asn Leu Ala Ser Gly Val 210 215 220 Pro Asp Arg Phe Ser Gly Ser
Gly Ser Gly Thr Ala Phe Thr Leu Arg 225 230 235 240 Ile Ser Arg Val
Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 245 250 255 His Leu
Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 260 265 270
Lys Arg Ala Asp Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 275
280 285 Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys
Arg 290 295 300 Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
Phe Ala Cys 305 310 315 320 Asp Phe Phe Ile Pro Leu Leu Val Val Ile
Leu Phe Ala Val Asp Thr 325 330 335 Gly Leu Phe Ile Ser Thr Gln Gln
Gln Val Thr Phe Leu Leu Lys Ile 340 345 350 Lys Arg Thr Arg Lys Gly
Phe Arg Leu Leu Asn Pro His Pro Lys Pro 355 360 365 Asn Pro Lys Asn
Asn Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys 370 375 380 Gly Asp
Val Glu Glu Asn Pro Gly Pro Met Asp Thr Glu Ser Asn Arg 385 390 395
400 Arg Ala Asn Leu Ala Leu Pro Gln Glu Pro Ser Ser Val Pro Ala
Phe
405 410 415 Glu Val Leu Glu Ile Ser Pro Gln Glu Val Ser Ser Gly Arg
Leu Leu 420 425 430 Lys Ser Ala Ser Ser Pro Pro Leu His Thr Trp Leu
Thr Val Leu Lys 435 440 445 Lys Glu Gln Glu Phe Leu Gly Val Thr Gln
Ile Leu Thr Ala Met Ile 450 455 460 Cys Leu Cys Phe Gly Thr Val Val
Cys Ser Val Leu Asp Ile Ser His 465 470 475 480 Ile Glu Gly Asp Ile
Phe Ser Ser Phe Lys Ala Gly Tyr Pro Phe Trp 485 490 495 Gly Ala Ile
Phe Phe Ser Ile Ser Gly Met Leu Ser Ile Ile Ser Glu 500 505 510 Arg
Arg Asn Ala Thr Tyr Leu Val Arg Gly Ser Leu Gly Ala Asn Thr 515 520
525 Ala Ser Ser Ile Ala Gly Gly Thr Gly Ile Thr Ile Leu Ile Ile Asn
530 535 540 Leu Lys Lys Ser Leu Ala Tyr Ile His Ile His Ser Cys Gln
Lys Phe 545 550 555 560 Phe Glu Thr Lys Cys Phe Met Ala Ser Phe Ser
Thr Glu Ile Val Val 565 570 575 Met Met Leu Phe Leu Thr Ile Leu Gly
Leu Gly Ser Ala Val Ser Leu 580 585 590 Thr Ile Cys Gly Ala Gly Glu
Glu Leu Lys Gly Asn Lys Val Pro Glu 595 600 605 Lys Arg Gly Arg Lys
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 610 615 620 Arg Pro Val
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 625 630 635 640
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Gly Val Lys Gln 645
650 655 Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser
Asn 660 665 670 Pro Gly Pro Met Ile Pro Ala Val Val Leu Leu Leu Leu
Leu Leu Val 675 680 685 Glu Gln Ala Ala Ala Leu Gly Glu Pro Gln Leu
Cys Tyr Ile Leu Asp 690 695 700 Ala Ile Leu Phe Leu Tyr Gly Ile Val
Leu Thr Leu Leu Tyr Cys Arg 705 710 715 720 Leu Lys Ile Gln Val Arg
Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser 725 730 735 Arg Val Lys Phe
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 740 745 750 Gln Asn
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 755 760 765
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 770
775 780 Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln
Lys 785 790 795 800 Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met
Lys Gly Glu Arg 805 810 815 Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
Gln Gly Leu Ser Thr Ala 820 825 830 Thr Lys Asp Thr Tyr Asp Ala Leu
His Met Gln Ala Leu Pro Pro Arg 835 840 845 1262547DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
polynucleotideMulti-chain CAR 126atggctcctg ccatggaatc ccctactcta
ctgtgtgtag ccttactgtt cttcgctcca 60gatggcgtgt tagcagaggt gcagttgcag
cagtcagggc cagagttgat taagcccgga 120gcctccgtca agatgtcctg
caaggccagc gggtacactt tcaccagcta cgtcatgcat 180tgggtgaagc
agaagccagg ccaggggctt gagtggattg ggtacatcaa cccctacaac
240gacgggacca aatacaacga gaaattcaag ggcaaagcca cactcacctc
cgataagtcc 300tcctctaccg cctacatgga gctcagctcc ctgacctccg
aggatagcgc tgtgtattac 360tgcgcaaggg gcacatacta ctatggctct
agggtgttcg actactgggg gcagggcact 420actctcacag tgagctcagg
cggaggaggc agtggcggag ggggaagtgg gggcggcggc 480agcgatattg
tcatgaccca ggcagcccct agtatccctg tgactccagg cgagagcgtg
540agcatcagct gccggtccag caagagcctg ctgaacagta acggaaacac
atacctctac 600tggtttctgc agaggcccgg ccagagccct cagctgctga
tttaccgcat gtcaaatctt 660gcctctgggg tgcccgatag atttagtggg
agcggatccg gcacagcttt tacattgcgg 720atctccagag tcgaggccga
agacgtgggg gtctattact gtatgcaaca cctggaatac 780ccctttacct
tcggagccgg cacaaagctg gagctgaagc gggctgacac cacaaccccc
840gctccaaggc cccctacccc cgcaccaact attgcctccc agccactctc
actgcggcct 900gaggcctgtc ggcccgctgc tggaggcgca gtgcatacaa
ggggcctcga tttcgcctgc 960gattttttta tcccattgtt ggtggtgatt
ctgtttgctg tggacacagg attatttatc 1020tcaactcagc agcaggtcac
atttctcttg aagattaaga gaaccaggaa aggcttcaga 1080cttctgaacc
cacatcctaa gccaaacccc aaaaacaaca gagccgaggg cagaggcagc
1140ctgctgacct gcggcgacgt ggaggagaac ccaggcccca tggacacaga
aagtaatagg 1200agagcaaatc ttgctctccc acaggagcct tccagtgtgc
ctgcatttga agtcttggaa 1260atatctcccc aggaagtatc ttcaggcaga
ctattgaagt cggcctcatc cccaccactg 1320catacatggc tgacagtttt
gaaaaaagag caggagttcc tgggggtaac acaaattctg 1380actgctatga
tatgcctttg ttttggaaca gttgtctgct ctgtacttga tatttcacac
1440attgagggag acattttttc atcatttaaa gcaggttatc cattctgggg
agccatattt 1500ttttctattt ctggaatgtt gtcaattata tctgaaagga
gaaatgcaac atatctggtg 1560agaggaagcc tgggagcaaa cactgccagc
agcatagctg ggggaacggg aattaccatc 1620ctgatcatca acctgaagaa
gagcttggcc tatatccaca tccacagttg ccagaaattt 1680tttgagacca
agtgctttat ggcttccttt tccactgaaa ttgtagtgat gatgctgttt
1740ctcaccattc tgggacttgg tagtgctgtg tcactcacaa tctgtggagc
tggggaagaa 1800ctcaaaggaa acaaggttcc agagaaacgg ggccggaaga
agctcctcta catttttaag 1860cagcctttca tgcggccagt gcagacaacc
caagaggagg atgggtgttc ctgcagattc 1920cctgaggaag aggaaggcgg
gtgcgagctg ggttctggcg tgaaacagac tttgaatttt 1980gaccttctca
agttggcggg agacgtggag tccaacccag ggcccatgat tccagcagtg
2040gtcttgctct tactcctttt ggttgaacaa gcagcggccc tgggagagcc
tcagctctgc 2100tatatcctgg atgccatcct gtttctgtat ggaattgtcc
tcaccctcct ctactgtcga 2160ctgaagatcc aagtgcgaaa ggcagctata
accagctatg agaaatcaag agtgaagttc 2220tccaggagcg cagatgcccc
cgcctatcaa cagggccaga accagctcta caacgagctt 2280aacctcggga
ggcgcgaaga atacgacgtg ttggataaga gaagggggcg ggaccccgag
2340atgggaggaa agccccggag gaagaaccct caggagggcc tgtacaacga
gctgcagaag 2400gataagatgg ccgaggccta ctcagagatc gggatgaagg
gggagcggcg ccgcgggaag 2460gggcacgatg ggctctacca ggggctgagc
acagccacaa aggacacata cgacgccttg 2520cacatgcagg cccttccacc ccggtga
25471279PRTUnknownDescription of Unknown 'LAGLIDADG' family motif
endonuclease sequence 127Leu Ala Gly Leu Ile Asp Ala Asp Gly 1 5
12830DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideForward adaptator sequence 128ccatctcatc
cctgcgtgtc tccgactcag 3012920DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotideLocus specific forward
sequence for GR exon 2 129ggttcattta acaagctgcc
2013020DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideLocus specific forward sequence for GR
exon 3 130gcattctgac tatgaagtga 2013129DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideLocus specific forward sequence for GR exon 5
131tcagcaggcc actacaggag tctcacaag 2913230DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideReverse adaptator sequence 132cctatcccct gtgtgccttg
gcagtctcag 3013320DNAArtificial SequenceDescription of Artificial
Sequence Synthetic oligonucleotideLocus specific reverse sequence
for GR exon 2 133agccagtgag ggtgaagacg 2013420DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideLocus specific reverse sequence for GR exon 3
134gggctttgca tataatggaa 2013529DNAArtificial SequenceDescription
of Artificial Sequence Synthetic oligonucleotideLocus specific
reverse sequence for GR exon 5 135ctgactctcc ccttcatagt ccccagaac
2913620DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideLocus specific forward sequence for CD52
136cagatctgca gaaaggaagc 2013721DNAArtificial SequenceDescription
of Artificial Sequence Synthetic oligonucleotideLocus specific
forward sequence for TRAC 137atcactggca tctggactcc a
2113822DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideLocus specific forward sequence for TRBC1
138agagccccta ccagaaccag ac 2213922DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideLocus specific forward sequence for TRBC2
139ggacctagta acataattgt gc 2214021DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideEndogenous locus specific reverse sequence for CD52
140cctgttggag tccatctgct g 2114120DNAArtificial SequenceDescription
of Artificial Sequence Synthetic oligonucleotideEndogenous locus
specific reverse sequence for TRAC 141cctcatgtct agcacagttt
2014221DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideEndogenous locus specific reverse sequence
for TRBC1 and TRBC2 142accagctcag ctccacgtgg t 2114320DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideLocus specific forward sequence for CTLA4_T01
143ctctacttcc tgaagacctg 2014420DNAArtificial SequenceDescription
of Artificial Sequence Synthetic oligonucleotideLocus specific
forward sequence for CTLA4_T03/T04 144acagttgaga gatggagggg
2014519DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideLocus specific forward sequence for
PDCD1_T01 145ccacagaggt aggtgccgc 1914620DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideLocus specific forward sequence for PDCD1_T03
146gacagagatg ccggtcacca 2014720DNAArtificial SequenceDescription
of Artificial Sequence Synthetic oligonucleotideEndogenous locus
specific reverse sequence for CTLA4_T01 147tggaatacag agccagccaa
2014820DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotideEndogenous locus specific reverse sequence
for CTLA4_T03/T04 148ggtgcccgtg cagatggaat 2014920DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideEndogenous locus specific reverse sequence for
PDCD1_T01 149ggctctgcag tggaggccag 2015020DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotideEndogenous locus specific reverse sequence for
PDCD1_T03 150ggacaacgcc accttcacct 2015117DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 151ttgtcccaca gatatcc 1715217DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 152ttcctcctac tcaccat 1715317DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 153ttgctctcac cagtata 1715417DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 154tcactcttac ctggacc 1715517DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 155tctcagatga tacaccc 1715617DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 156tgatcccaca gaaatac 1715717DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 157ttcctctaac ctgtatt 1715817DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 158tagtccccca gatatga 1715917DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 159ttgtcacaca tataccg 1716017DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 160taactcttac ctgtagt 1716117DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 161ttactccaac taactat 1716217DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 162tggctcatac ctgtagt 1716317DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 163ttgctcatac atgtgca 1716417DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 164ttgtcccaca gacattc 1716517DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 165tcacacctgg tacatag 1716617DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 166ttgtcccaca gctaccc 1716717DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 167tctcaactga aacaagg 1716817DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 168ccgtgtacca gctgaga 1716917DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 169ggtacaggta agagcaa 1717017DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 170ttttcaggta agtgcaa 1717118DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 171cctacaggtt aagggcca 1817217DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 172agtacaggca tgagcca 1717317DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 173gcatttctgt gggatca 1717417DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 174gatccaggta aggtcaa 1717517DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 175aaggtgtgga tgaggaa 1717617DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 176tggtatttgt gtgacaa 1717717DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 177agatttctct ggggcaa 1717817DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 178ccgtttaccg gcttaga 1717917DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 179aggatgaggt ggaggaa 1718017DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 180atgctgtgta ggtggta 1718117DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 181ccacgtagca gctggga 1718217DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 182gtgtttagta gggggaa 1718317DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 183gagtctttgt aggacaa 1718417DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 184tgtaatgtca agagcaa 17185116DNAHomo sapiens
185catgtcctaa ccctgatcct cttgtcccac agatatccag aaccctgacc
ctgccgtgta 60ccagctgaga gactctaaat ccagtgacaa gtctgtctgc ctattcaccg
attttg 11618699DNAHomo sapiens 186catgtcctaa ccctgatcct cttgtcccac
agatatccgt gtaccagctg agagactcta 60aatccagtga caagtctgtc tgcctattca
ccgattttg 99187107DNAHomo sapiens 187catgtcctaa ccctgatcct
cttgtcccac agatatccag atatccgtgt accagctgag
60agactctaaa tccagtgaca agtctgtctg cctattcacc gattttg
10718885DNAHomo sapiens 188catgtcctaa ccctcgatcc tgccgtgtac
cagctgagag actctaaatc cagtgacaag 60tctgtctgcc tattcaccga ttttg
85189111DNAHomo sapiens 189catgtcctaa ccctgatcct cttgtcccac
agatatccag atatcctgcc gtgtaccagc 60tgagagactc taaatccagt gacaagtctg
tctgcctatt caccgatttt g 111190104DNAHomo sapiens 190catgtcctaa
ccctgatcct cttgtcccac agatatccag aaccctgacc agctgagaga 60ctctaaatcc
agtgacaagt ctgtctgcct attcaccgat tttg 10419145DNAHomo sapiens
191catgtcctaa ccctgatcct cttgtcccac agatatccga ttttg 4519278DNAHomo
sapiens 192catgtcctaa ccctgatcct cttgtcccac gagactctaa atccagtgac
aagtctgtct 60gcctattcac cgattttg 78193109DNAHomo sapiens
193catgtcctaa ccctgatcct cttgtcccac agatatccag aacctgccgt
gtaccagctg 60agagactcta aatccagtga caagtctgtc tgcctattca ccgattttg
10919489DNAHomo sapiens 194catgtcctaa ccctgatcct cttgtcccac
agaccagctg agagactcta aatccagtga 60caagtctgtc tgcctattca ccgattttg
89
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