U.S. patent application number 15/979140 was filed with the patent office on 2018-11-15 for systems and methods for predicting seizures.
The applicant listed for this patent is Eco-Fusion. Invention is credited to Oren Fuerst.
Application Number | 20180325443 15/979140 |
Document ID | / |
Family ID | 54188695 |
Filed Date | 2018-11-15 |
United States Patent
Application |
20180325443 |
Kind Code |
A1 |
Fuerst; Oren |
November 15, 2018 |
SYSTEMS AND METHODS FOR PREDICTING SEIZURES
Abstract
The present invention provides for a computer system including
at least one server having software stored on a non-transient
computer readable medium; where, upon execution of the software,
the at least one server is at least configured to: i) receiving
physiological data representative of a first physiological
measurement of at least one physiological characteristic of an
epileptic user; ii) receiving physiological data representative of
a second physiological measurement of at least one physiological
characteristic of the epileptic user; iii) comparing the first
physiological measurement of the epileptic user to the second
physiological measurement of the epileptic user; iv) based on the
comparing, determining that a difference between the first
physiological measurement of the epileptic user and the second
physiological measurement is: a) higher than a predetermined
threshold value, or b) smaller than the predetermined threshold
value; and v) generating at least one alert; vi) transmitting the
at least one alert.
Inventors: |
Fuerst; Oren; (Ramat
Hasharon, IL) |
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Applicant: |
Name |
City |
State |
Country |
Type |
Eco-Fusion |
Ramat Gan |
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IL |
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|
Family ID: |
54188695 |
Appl. No.: |
15/979140 |
Filed: |
May 14, 2018 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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14670169 |
Mar 26, 2015 |
9968288 |
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15979140 |
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61970470 |
Mar 26, 2014 |
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Current U.S.
Class: |
1/1 |
Current CPC
Class: |
A61B 5/746 20130101;
A61B 5/7465 20130101; A61B 5/1101 20130101; A61B 5/7246 20130101;
A61B 5/02055 20130101; A61M 5/1723 20130101; A61B 5/681 20130101;
A61N 1/37282 20130101; A61M 21/02 20130101; A61B 5/0533 20130101;
G16H 40/67 20180101; A61N 1/37258 20130101; A61B 5/14542 20130101;
A61B 5/4094 20130101; A61B 5/02416 20130101; A61M 2205/054
20130101; A61B 5/02405 20130101; A61N 1/36064 20130101 |
International
Class: |
A61B 5/00 20060101
A61B005/00; A61N 1/372 20060101 A61N001/372; G16H 40/67 20180101
G16H040/67; A61N 1/36 20060101 A61N001/36; A61B 5/0205 20060101
A61B005/0205; A61M 5/172 20060101 A61M005/172 |
Claims
1. A computer system, comprising: a) at least one wearable garment,
comprising a plurality of non-invasive sensors; i) wherein the
plurality of non-invasive sensors are configured to continuously
acquire, in real-time, a plurality of biosignals from a person
wearing the at least one wearable garment; ii) wherein the
plurality of biosignals comprise biosignals representative of heart
rate variability (HRV) and electrodermal activity (EDA); iii)
wherein the at least one wearable garment is configured to
wirelessly transmit the plurality of biosignals to at least one
portable computing device associated with the person wearing the at
least one wearable garment; b) the at least one portable computing
device having software stored on a non-transient computer readable
medium; wherein, upon execution of the software, the at least one
portable computing device is at least configured to: i) receiving,
in real-time, a current set of the plurality of biosignals which
are representative of a current value of at least one power
spectral component of the heart rate variability (current HRV
value) and a current value of the electrodermal activity (current
EDA value); ii) dynamically calculating, in real-time, based on the
current set of the plurality of biosignals, the current HRV value
and the current EDA value; iii) dynamically comparing, in
real-time, 1) the current HRV value to at least-a population
historical HRV value of a population of people, wherein each person
of the population of people has at least one characteristic
associated with at least one of a current psychological condition
of the person and a current physiological condition of the person
and wherein the at least one characteristic of the current
physiological condition of the person is dependent on a food intake
of the person; and 2) the current EDA value to at least a
population historical EDA value of the population of people; iv)
based on the comparing, dynamically determining, in real-time, a
presence of at least one health-related condition; v) dynamically
generating, in real-time, at least one alert when the presence of
the at least one health-related condition has been determined; and
vi) at least one of: 1) dynamically appraising, via the at least
one portable computing device, the person about the at least one
alert, and 2) dynamically and wirelessly transmitting, in
real-time, the at least one alert to at least one of: a first
electronic device associated with the at least one family member, a
second electronic device associated with at least one medical
practitioner, or any combination thereof.
2. The computer system of claim 1, wherein the at least one
portable computing device is further configured to dynamically
transmitting, in real-time, the at least one alert to a third
electronic device; and therein the third electronic device is
configured to reside in the at least one wearable garment.
3. The computer system of claim 1, wherein the first electronic
device and the second electronic device are portable electronic
devices.
4. The computer system of claim 1, wherein the dynamically
appraising, via the at least one portable computing device, the
person about the at least one alert comprises dynamically
outputting at least one of at least one visual alert and at least
one audio alert.
5. The computer system of claim 1, wherein the at least one
characteristic of the current psychological condition of the person
is a stress level.
6. The computer system of claim 1, wherein the at least one
characteristic of the current physiological condition of the person
is a heart rate.
7. A computer-implemented method, comprising: providing at least
one wearable garment, comprising a plurality of non-invasive
sensors; i) wherein the plurality of non-invasive sensors are
configured to continuously acquire, in real-time, a plurality of
biosignals from a person wearing the at least one wearable garment;
ii) wherein the plurality of biosignals comprise biosignals
representative of heart rate variability (HRV) and electrodermal
activity (EDA); iii) wherein the at least one wearable garment is
configured to wirelessly transmit the plurality of biosignals to at
least one portable computing device associated with the person
wearing the at least one wearable garment; programming the at least
one portable computing device with a software to be stored on a
non-transient computer readable medium; wherein, upon execution of
the software, the at least one portable computing device is at
least configured to: i) receiving, in real-time, a current set of
the plurality of biosignals which are representative of a current
value of at least one power spectral component of the heart rate
variability (current HRV value) and a current value of the
electrodermal activity (current EDA value); ii) dynamically
calculating, in real-time, based on the current set of the
plurality of biosignals, the current HRV value and the current EDA
value; iii) dynamically comparing, in real-time, 1) the current HRV
value to at least a population historical HRV value of a population
of people, wherein each person of the population of people has at
least one characteristic associated with at least one of a current
psychological condition of the person and a current physiological
condition of the person and wherein the at least one characteristic
of the current physiological condition of the person is dependent
on a food intake of the person; and 2) the current EDA value to at
least a population historical EDA value of the population of
people; iv) based on the comparing, dynamically determining, in
real-time, a presence of at least one health-related condition; v)
dynamically generating, in real-time, at least one alert when the
presence of the at least one health-related condition has been
determined; and vi) at least one of: 1) dynamically appraising, via
the at least one portable computing device, the person about the at
least one alert, and 2) dynamically and wirelessly transmitting, in
real-time, the at least one alert to at least one of: a first
electronic device associated with the at least one family member, a
second electronic device associated with at least one medical
practitioner, or any combination thereof.
8. The method of claim 7, wherein the at least one portable
computing device is further configured to dynamically transmitting,
in real-time, the at least one alert to a third electronic device;
and therein the third electronic device is configured to reside in
the at least one wearable garment.
9. The method of claim 7, wherein the first electronic device and
the second electronic device are portable electronic devices.
10. The method of claim 7, wherein the dynamically appraising, via
the at least one portable computing device, the person about the at
least one alert comprises dynamically outputting at least one of at
least one visual alert and at least one audio alert.
11. The method of claim 7, wherein the at least one characteristic
of the current psychological condition of the person is a stress
level.
12. The method of claim 7, wherein the at least one characteristic
of the current physiological condition of the person is a heart
rate.
Description
RELATED APPLICATIONS
[0001] This application is a continuation of U.S. patent
application Ser. No. 14/670,169; filed Mar. 26, 2015; entitled
"SYSTEMS AND METHODS FOR PREDICTING SEIZURES", which claims
priority of U.S. Patent Appln. No. 61/970,470; filed Mar. 26, 2014;
entitled "SYSTEM AND METHOD OF PREDICTING EPILEPTIC SEIZURES AND
ISSUING ASSOCIATED ALERTS," which are incorporated herein by
reference in their entirety for all purposes.
TECHNICAL FIELD
[0002] In some embodiments, the instant invention is related to
computer methods/systems to predict and alert about seizures.
BACKGROUND
[0003] Epilepsy is a group of neurological disorders characterized
by epileptic seizures. Epileptic seizures are episodes that can
vary from brief and nearly undetectable to long periods of vigorous
shaking. In epilepsy, seizures tend to recur, and have no immediate
underlying cause while seizures that occur due to a specific cause
are not deemed to represent epilepsy.
SUMMARY OF INVENTION
[0004] In some embodiments, the instant invention provides for a
computer system, including: a) at least one server having software
stored on a non-transient computer readable medium; where, upon
execution of the software, the at least one server is at least
configured to: i) receiving, in real-time, physiological data
representative of a first physiological measurement of at least one
physiological characteristic of the user, wherein the at least one
physiological characteristic is selected from the group consisting
of: heart rate, heart rate variability, oxygen saturation,
temperature, hand movement, body movement, galvanic skin response,
or any combination thereof; ii) receiving, in real-time,
physiological data representative of a second physiological
measurement of at least one physiological characteristic of the
user, wherein the at least one physiological characteristic is
selected from the group consisting of: heart rate, heart rate
variability, oxygen saturation, temperature, hand movement,
galvanic skin response, or any combination thereof; iii) comparing,
in real-time, the first physiological measurement of the user to
the second physiological measurement of the user; iv) based on the
comparing, determining, in real-time, that a difference between the
first physiological measurement of the user and the second
physiological measurement is: a) higher than a predetermined
threshold value, or b) smaller than the predetermined threshold
value, and then: v) generating, in real-time, at least one alert
when the at least one pre-determined physiological value is higher
than the predetermined threshold value; vi) transmitting, in
real-time, the at least one alert to at least one of: the user, at
least one family member, at least one medical practitioner, or any
combination thereof; and vii) when the at least one pre-determined
physiological value is smaller than the predetermined threshold
value, causing to continue measuring, in real-time, the at least
one physiological characteristic of the user.
[0005] In some embodiments, the instant invention provides for a
method of treatment, including: when at least one alert generated
by at least one wearable computing device is received by a user,
administering an effective amount of an epileptic-directed
treatment to the user so as to reduce a severity or occurrence of
an imminent epileptic seizure, where the epileptic-directed
treatment is selected from the group consisting of an
epileptic-directed medication, electrotherapy, relaxation therapy,
and breathing therapy, where the at least one alert is generated
regarding at least one physiological condition; where the at least
one alert is generated when a measurement of the at least one
physiological condition is higher than at least one predetermined
threshold measurement, where the at least one physiological
condition of the user is selected from the group consisting of:
heart rate, heart rate variability, oxygen saturation, PPG signal,
temperature, hand movement, galvanic skin response, or any
combination thereof, where at least one alert is transmitted to at
least one of: the user, at least one family member, at least one
medical practitioner, or any combination thereof, and where, when
the measurement of the at least one physiological condition is
smaller than the predetermined threshold measurement, continuing to
measure the at least one physiological condition of the user. In
some embodiments, the at least one alert is further generated when
a first physiological measurement is compared to a second
physiological measurement, the second physiological measurement is
selected from the group consisting of: heart rate, heart rate
variability, oxygen saturation, temperature, hand movement,
galvanic skin response, PPG signal, or any combination thereof, the
at least one alert is generated when a difference between the first
physiological measurement of the user and the second physiological
measurement is higher than a predetermined threshold value.
[0006] In some embodiments, the instant invention provides for a
computer method, including: i) receiving, in real-time,
physiological data representative of a first physiological
measurement of at least one physiological characteristic of the
user, wherein the at least one physiological characteristic is
selected from the group consisting of: heart rate, heart rate
variability, oxygen saturation, temperature, hand movement, body
movement, galvanic skin response, or any combination thereof; ii)
receiving, in real-time, physiological data representative of a
second physiological measurement of at least one physiological
characteristic of the user, wherein the at least one physiological
characteristic is selected from the group consisting of: heart
rate, heart rate variability, oxygen saturation, temperature, hand
movement, galvanic skin response, or any combination thereof; iii)
comparing, in real-time, the first physiological measurement of the
user to the second physiological measurement of the user; iv) based
on the comparing, determining, in real-time, that a difference
between the first physiological measurement of the user and the
second physiological measurement is: a) higher than a predetermined
threshold value, or b) smaller than the predetermined threshold
value, and then: v) generating, in real-time, at least one alert
when the at least one pre-determined physiological value is higher
than the predetermined threshold value; vi) transmitting, in
real-time, the at least one alert to at least one of: the user, at
least one family member, at least one medical practitioner, or any
combination thereof; and vii) when the at least one pre-determined
physiological value is smaller than the predetermined threshold
value, causing to continue measuring, in real-time, the at least
one physiological characteristic of the user.
[0007] In some embodiments, the instant invention provides for a
computer system, including: a) at least one server having software
stored on a non-transient computer readable medium; where, upon
execution of the software, the at least one server is at least
configured to: i) receiving, an input from a user, where the input
includes user data consisting of: food intake of the user,
medication intake by the user, stress related events in the
preceding day, insulin dose taken by the user, or any combination
thereof; ii) receiving, in real-time, physiological data
representative of at least one physiological measurement of at
least one physiological characteristic of the user, where the at
least one physiological characteristic is selected from the group
consisting of: heart rate, heart rate variability, oxygen
saturation, temperature, galvanic skin response, or any combination
thereof; iii) comparing, in real-time, the at least one
physiological measurement of the user to at least one
pre-determined physiological value associated with the at least one
physiological characteristic retrieved from at least one database;
iv) based on the comparing, determining, in real-time, that a
difference between the at least one physiological measurement of
the user and the at least one pre-determined physiological value
is: a) higher than a predetermined threshold value, or b) smaller
than the predetermined threshold value, and then: v) generating, in
real-time, at least one alert when the at least one pre-determined
physiological value is higher than the predetermined threshold
value; vi) transmitting, in real-time, the at least one alert to at
least one of: the user, at least one family member, at least one
medical practitioner, or any combination thereof; and vii) when the
at least one pre-determined physiological value is smaller than the
predetermined threshold value, causing to continue measuring, in
real-time, the at least one physiological characteristic of the
user.
[0008] In some embodiments, the instant invention provides for a
computer method, including: i) receiving, an input from a user or
from his medical record, where the input includes user data
consisting of: food intake of the user, stress related events in
the preceding day, medication intake by the user, or any
combination thereof; ii) receiving, in real-time, physiological
data representative of at least one physiological measurement of at
least one physiological characteristic of the user, where the at
least one physiological characteristic is selected from the group
consisting of: heart rate, heart rate variability, oxygen
saturation, temperature, galvanic skin response, or any combination
thereof; iii) comparing, in real-time, the at least one
physiological measurement of the user to at least one
pre-determined physiological value associated with the at least one
physiological characteristic retrieved from at least one database;
iv) based on the comparing, determining, in real-time, that a
difference between the at least one physiological measurement of
the user and the at least one pre-determined physiological value
is: a) higher than a predetermined threshold value, or b) smaller
than the predetermined threshold value, and then: v) generating, in
real-time, at least one alert when the at least one pre-determined
physiological value is higher than the predetermined threshold
value; vi) transmitting, in real-time, the at least one alert to at
least one of: the user, at least one family member, at least one
medical practitioner, or any combination thereof; and vii) when the
at least one pre-determined physiological value is smaller than the
predetermined threshold value, causing to continue measuring, in
real-time, the at least one physiological characteristic of the
user.
[0009] In some embodiments, the instant invention provides for a
computer system, including: a) at least one server having software
stored on a non-transient computer readable medium; where, upon
execution of the software, the at least one server is at least
configured to: i) receiving, in real-time, an input from a user,
where the input includes user data consisting of: food intake of
the user, medication intake by the user, or any combination
thereof; ii) receiving, in real-time, physiological data
representative of at least one physiological measurement of at
least one physiological characteristic of the user, where the at
least one physiological characteristic is selected from the group
consisting of: heart rate, heart rate variability, oxygen
saturation, temperature, galvanic skin response, or any combination
thereof; iii) comparing, in real-time, the at least one
physiological measurement of the user to at least one
pre-determined physiological value associated with the at least one
physiological characteristic retrieved from at least one database;
iv) based on the comparing, determining, in real-time, that a
difference between the at least one physiological measurement of
the user and the at least one pre-determined physiological value
is: a) higher than a predetermined threshold value, or b) smaller
than the predetermined threshold value, and then: v) generating, in
real-time, at least one alert when the at least one pre-determined
physiological value is higher than the predetermined threshold
value; vi) transmitting, in real-time, the at least one alert to at
least one of: the user, at least one family member, at least one
medical practitioner, or any combination thereof; and vii) when the
at least one pre-determined physiological value is smaller than the
predetermined threshold value, causing to continue measuring, in
real-time, the at least one physiological characteristic of the
user.
[0010] In some embodiments, the instant invention provides for a
computer method, including: i) receiving, in real-time, an input
from a user, where the input includes user data consisting of: food
intake of the user, medication intake by the user, or any
combination thereof; ii) receiving, in real-time, physiological
data representative of at least one physiological measurement of at
least one physiological characteristic of the user, where the at
least one physiological characteristic is selected from the group
consisting of: heart rate, heart rate variability, oxygen
saturation, temperature, galvanic skin response, or any combination
thereof; iii) comparing, in real-time, the at least one
physiological measurement of the user to at least one
pre-determined physiological value associated with the at least one
physiological characteristic retrieved from at least one database;
iv) based on the comparing, determining, in real-time, that a
difference between the at least one physiological measurement of
the user and the at least one pre-determined physiological value
is: a) higher than a predetermined threshold value, or b) smaller
than the predetermined threshold value, and then: v) generating, in
real-time, at least one alert when the at least one pre-determined
physiological value is higher than the predetermined threshold
value; vi) transmitting, in real-time, the at least one alert to at
least one of: the user, at least one family member, at least one
medical practitioner, or any combination thereof; and vii) when the
at least one pre-determined physiological value is smaller than the
predetermined threshold value, causing to continue measuring, in
real-time, the at least one physiological characteristic of the
user.
[0011] An embodiment of the present invention is a
computer-implemented method, comprising: receiving, by a
specifically programed processing computer system, from an
electronic monitoring system, at least two of the following: i) a
first data from the electronic monitoring system, wherein the first
data from the electronic monitoring system is selected from the
group consisting of: a first heart beat, a first heart beat
variability, a first low frequency heart beat variability, a first
high frequency heart beat variability, a first level of movement,
and a first blood saturation level, and ii) a second data from the
electronic monitoring system, wherein the second data from the
electronic monitoring system is selected from the group consisting
of: a second heart beat, a second heart beat variability, a second
low frequency heart beat variability, a second high frequency heart
beat variability, a second level of movement, and second blood
saturation level; comparing the first data from the electronic
monitoring system to the second data from the electronic monitoring
system, wherein the electronic monitoring system identifies at
least one deviation of a user, wherein the user is patient
diagnosed with epilepsy; sending, by the specifically programed
processing computer system, at least one alert to at least one
designated responder, wherein the at least one designated responder
is selected from the group consisting of: a member of a medical
team and a member of the family; generating, in response to the
receiving the alert by the specifically programed processing
computer system, a notification to the at least one designated
responder; sending, by the specifically programed processing
computer system, the notification to the at least one designated
responder; receiving, by the at least one designated responder, the
notification; wherein the at least one designated responder
receives the notification by the specifically programed processing
computer system.
BRIEF DESCRIPTION OF THE DRAWINGS
[0012] The present invention will be further explained with
reference to the attached drawings, wherein like structures are
referred to by like numerals throughout the several views. The
drawings shown are not necessarily to scale, with emphasis instead
generally being placed upon illustrating the principles of the
present invention. Further, some features may be exaggerated to
show details of particular components.
[0013] The figures constitute a part of this specification and
include illustrative embodiments of the present invention and
illustrate various objects and features thereof. Further, the
figures are not necessarily to scale, some features may be
exaggerated to show details of particular components. In addition,
any measurements, specifications and the like shown in the figures
are intended to be illustrative, and not restrictive. Therefore,
specific structural and functional details disclosed herein are not
to be interpreted as limiting, but merely as a representative basis
for teaching one skilled in the art to variously employ the present
invention.
[0014] FIGS. 1 and 2 illustrates some embodiments of the inventive
system of the present invention, showing users suffering from
epilepsy connecting over network servers in accordance with the
invention.
[0015] FIG. 3 illustrates some embodiments of the inventive system
of the present invention, showing a system receiving inputs
provided by a user diagnosed with epilepsy.
[0016] FIG. 4 illustrates some embodiments of the inventive system
of the present invention, showing a wristband configured to include
the system of the present invention.
[0017] FIG. 5 illustrates a flow diagram of an embodiment of the
inventive system of the present invention.
[0018] FIG. 6 illustrates an embodiment of the inventive system of
the present invention, showing sensors for use in connection with
the system.
[0019] FIG. 7 illustrates an embodiment of a watch configured to
use the inventive system.
[0020] FIGS. 8 and 9 illustrate some embodiments of the system of
the present invention.
DESCRIPTION OF EXEMPLARY EMBODIMENTS
[0021] Among those benefits and improvements that have been
disclosed, other objects and advantages of this invention will
become apparent from the following description taken in conjunction
with the accompanying figures. Detailed embodiments of the present
invention are disclosed herein; however, it is to be understood
that the disclosed embodiments are merely illustrative of the
invention that may be embodied in various forms. In addition, each
of the examples given in connection with the various embodiments of
the invention which are intended to be illustrative, and not
restrictive.
[0022] Throughout the specification and claims, the following terms
take the meanings explicitly associated herein, unless the context
clearly dictates otherwise. The phrases "in one embodiment" and "in
some embodiments" as used herein do not necessarily refer to the
same embodiment(s), though it may. Furthermore, the phrases "in
another embodiment" and "in some other embodiments" as used herein
do not necessarily refer to a different embodiment, although it
may. Thus, as described below, various embodiments of the invention
may be readily combined, without departing from the scope or spirit
of the invention.
[0023] In addition, as used herein, the term "or" is an inclusive
"or" operator, and is equivalent to the term "and/or," unless the
context clearly dictates otherwise. The term "based on" is not
exclusive and allows for being based on additional factors not
described, unless the context clearly dictates otherwise. In
addition, throughout the specification, the meaning of "a," "an,"
and "the" include plural references. The meaning of "in" includes
"in" and "on."
[0024] In some embodiments, the present invention is an alert
mechanism for epilepsy. In some embodiments, the present invention
is a non-invasive alert system for epilepsy. In some embodiments,
the present invention is an alarm system. In some embodiments, the
present invention is configured to save the lives of people
suffering from epilepsy.
[0025] In some embodiments, the present invention is an alert
mechanism for epilepsy. In some embodiments, the alert mechanism is
based on a deviation from the calculated expected value of at least
one of the following: heart beat, heart beat variability, low
frequency heart beat, high frequency heart beat variability, level
of movement, and blood saturation level. In some embodiments, the
present invention is based on at least one of the following input
parameters: food eaten prior to going to sleep, physical activity
during the preceding day, and stress level prior to going to
sleep.
[0026] FIG. 1 illustrates an embodiment of the present
invention.
[0027] FIG. 2 illustrates an embodiment of the network architecture
of the present invention.
[0028] FIG. 3 illustrates an embodiment of the system of the
present invention.
[0029] FIG. 4 is an embodiment of a hand with the wristband.
[0030] FIG. 5 is a block flow diagram of the process of the present
invention.
[0031] FIG. 6 is an embodiment of a view of a sample of typical PPG
(Photoplethysmography) sensors with Motion immunity using a 3d
Accelerometer sensor. In some embodiments, the sensor can be used
as a sensor to detect Heart Rate Variability (HRV) and movement of
the hand. In some embodiments, additional sensors can be added to
include other parameters, such as blood oxygen.
[0032] FIG. 7 illustrates an embodiment of a wrist-band of the
present invention.
[0033] FIGS. 8 and 9 illustrate some further aspects of some
embodiments of the present invention.
Epileptic Seizures
[0034] In some embodiments, the inventive system of the present
invention allows for the monitoring of symptoms of epileptic
seizures, which may be idiosyncratic/unique/personalized to a
person, but people generally learn to recognize his/her unique
symptoms. In some embodiments, symptoms of epileptic seizures are
neurogenic (autonomic) symptoms which, for example, may include,
but are not limited to, palpitations, tremor, hunger, and sweating.
In some embodiments, neuroglycopenic symptoms typically include
behavioral changes, difficulty thinking, confusion, or any
combination thereof. In some embodiments, neuroglycopenic
manifestations can include seizure, coma, and even death.
[0035] In some embodiments, the system of the present invention is
configured to identify heart rate (HR) variability, which is
typically used to detect autonomic dysfunction in clinical
settings. In some embodiments, patients suffering from epilepsy may
exhibit a marked decrease in the low-frequency component of heart
rate variability during spontaneous epileptic seizure. In some
embodiments, the correlation of a decrease in the low-frequency
component of heart rate variability with an epileptic seizure
events can serve as a prediction mechanism, where additional
medical and non medical parameters can be utilized as additional
parameters in order to define a pathway for the HRV during the day
or night, and hence to look for deviations from the pathway that
will trigger a plurality of alerts, as such deviations may indicate
an epileptic seizure.
[0036] In some embodiments, the present invention is an alert
system configured to obtain/receive and/or store/record: (i) the
food intake of the user, (ii) the medication taken by the user, and
(iii) heart rate and/or heart rate variability parameters of the
user. In an embodiment, the system is configured to calculate an
expected heart rate and/or heart rate variability, and where an
identification of extreme deviations from these values occurs, the
system is configured to create and/or deliver an epileptic seizure
alert to a user, an emergency contact(s), a doctor, a hospital, or
any combination thereof. In some embodiments, the calculation of
heart rate and/or heart rate variability occurs after a measurement
of a person's heart rate is recorded by the system. In some
embodiments, the system is configured to obtain, record, calculate,
or any combination thereof, a plurality of measurements from a
plurality of samples obtained during a plurality of time
points.
[0037] FIG. 3 illustrates an embodiment of the system of the
present invention. FIG. 3 shows, as a non-limiting example, a
wristband (the system of the present invention can also be combined
in an armband or any other non-invasive wearable sensor) 710 worn
by a user 720, where the wristband is configured to communicate by
a communication standard such as, but not limited to, Bluetooth 730
with a mobile device such as, but not limited to, an iPhone 740. In
an embodiment, the system includes a mobile device 740 which is
configured to incorporate an application/software configured to
capture a plurality of bio-signals, e.g., but not limited to, heart
rate and the heart rate variability of a user, generated/obtained
from the wristband 710. In an embodiment, the system is configured
to obtain additional biosignals captured from a user's body from a
plurality of sensors housed on the wristband including, but not
limited to, blood oxygen, galvanic response, skin temperature, or
any combination thereof.
[0038] FIG. 4 illustrates an embodiment of the system of the
present invention, where the system is configured to calculate
heart rate variability by use of, e.g., but not limited to, the
mobile device, where the heart rate variability is measured and
identified by the system when the frequency of the heart
beat-to-beat sampling is sufficiently/substantially high, for
example, but not limited to, a measurement of about 108 hz. In
another embodiment, the system is configured to send
information/data from an application/software to, e.g., but not
limited to, a Data Center 750, where the Data Center manages Big
Data analysis. In an embodiment, information/data is managed by:
(i) being stored and/or compared to a plurality of users' data,
(ii) benchmarking the user's data to the user's historical data,
(iii) back-testing, (iv) storing, (v) routing data/information to
medical personnel (e.g., but not limited to, doctors, nurses, nurse
practitioners, EMTs, etc., or any combination thereof), or any
combination thereof.
[0039] In some embodiments, the system of the present invention is
configured to identify/measure a sudden drop in the heart rate
variability and/or component(s) of heart rate variability (e.g.,
but not limited to, the low frequency component(s)), where the
sudden drop in the heart rate variability and/or component of heart
rate variability is/are an indication(s) of a forthcoming epileptic
seizure event. In some embodiments, the system includes an alert
configured to trigger an alarm on, e.g., but not limited to, at
least one mobile phone. In some embodiments, the system is
configured to send at least one alert/a plurality of alerts to at
least one medical team and/or at least one family member of the
user.
[0040] FIG. 5 illustrates an embodiment of the system of the
present invention, including an initial setting up phase 9.1, where
the system is configured to receive a plurality of inputs
provided/delivered by a user which define his preference set, for
example, but not limited to, medications, including dosing and
morning/afternoon/evening medication, favorite foods, glycemic
index for different foods if needed, for example, when the user's
known digestion is different from the otherwise known glycemic
index. In another embodiment, at step 9.2, the system is configured
to receive a user's entry/input, where the user's entry/input can
be the user's last food intake before going to sleep, stress level
(if, for example, the wrist band was not worn during the day and
the information was not captured during the day by the system
already), information regarding medications taken and which might
still be influencing the likelihood of an epileptic seizure (such
as, e.g., but not limited to, stress and anxiety reducing
medication). In an embodiment, at stage 9.3, the system is
configured to continuously analyze information/data input and/or
collected from the wrist band. In another embodiment, the
information/data can include multi-parameters from at least one of
the following measurements: beat-to-beat heart rate, heart rate
variability and heart rate variability components, oxygen level,
skin temperature, galvanic skin response, or any combination
thereof. In another embodiment, the system is configured to analyze
the information/data for changes/deviations compared with an
expected information/data projected for the same time during the
night sleep or during the day for the same user when compared to a
benchmark on the data base, which is located at the mobile device
740 and the data center 750 and/or the cpu level located on the
wrist band 710. In some embodiments, the expected value can be
derived many different ways, for example using the historical
pattern of the same user or similar users or patients given similar
scenarios of food intake and heart rate and stress level readings
before going to sleep. In some embodiments, a pathway of a reading
of 120 with a stressful day (as measured by, e.g., but not limited
to, questionnaires and HRV or galvanic skin readings) and an
evening meal filled with carbs will be compared to a population of
similar pattern. In some embodiments, pattern recognition and
parameters of interest may correlate to the above parameters but
can correlate to combination of parameters, as such parameters may
arise from statistical analysis using tools such as discriminant,
neural network or principal component analysis.
[0041] In an embodiment, the system is configured to compare the
calculated expected values with the actual. In an embodiment, the
system is configured to receive/record/account the prior
information known about the user, such as, but not limited to, the
food eaten in the meal prior to going to sleep. In an embodiment,
the system is configured to trigger and/or send at least one alert
(e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 etc. alerts) when, according
to the comparison of the system noted in 9.5, there is a
substantially significant change from what would have been
expected, to: wake up the person 9.6.1, to alert the family, 9.6.2,
alert the medical team 9.6.3, or any combination thereof.
[0042] In another embodiment, the system of the present invention
includes triggers for an alarm which is configured to be adjusted
based on the habits of the user.
[0043] In some embodiments, the amount of food and medication prior
to going to sleep will have an impact on the probability of an
epileptic attack and the time during sleep, if at all, of an
epileptic attack event to occur. In some embodiments, additional
events on the day prior to the night sleep influence the likelihood
of epileptic seizure to occur. In some embodiment, levels of stress
are configured to be measured by the wristband by the HRV that was
measured during the preceding day, as captured by the
application/software of the system. In an embodiment, there is a
correlation between higher the level of stress and the higher
occurrence for a epileptic seizure event.
The Autonomic Nervous System (ANS)
[0044] Table 1 outlines which organs are affected by the
sympathetic (SNS) and parasympathetic (PSNS) nervous systems.
Typically, the SNS initiates a "fight or flight" response to
stress. The SNS increases heart rate, dilates or opens the lungs,
inhibits digestion and dilates the pupils, providing the body with
the resources it needs to protect itself in times of danger. The
PSNS conversely, is known as the "rest and digest" system; it
promotes digestion, reduces heart rate, increases salivation,
increases urine secretion from the kidneys and constricts the
pupils. On a day-to-day basis, these two pathways work in parallel
to maintain homeostatic balance within the body.
TABLE-US-00001 TABLE 1 Mechanism of Action Blood Inhibition of
Glucose entry Hormone glucose gluconeogenesis (liver) stimulation
(muscle) Insulin .dwnarw. Stimulation of glucose -- storage,
glycogen formation (liver, muscle) Adrenaline .uparw. --
Stimulation of glycogen breakdown to active molecules (liver,
muscle) Glucagon .uparw. Stimulation of glucose -- storage (liver)
Stimulation of glucose formation from non-carbohydrate substrates
(liver) Cortisol .uparw. -- Stimulation of glucose formation from
non-carbohydrate substrates (liver) Growth .uparw. -- Mobilization
of hormone triglycerides
Heart Rate Variability (HRV) and Epilepsy
[0045] In some embodiments, the system of the present invention is
configured to identify a correlation between probability and timing
of epileptic seizure, HRV and other physiological parameters. For
example, patients suffering from Epilepsy show lower than average
HRV.
[0046] Epileptic seizures are typically joined by changes in bodily
functions such as, but not limited to, changes in heart rate (HR),
Heart Rate Variability (HRV) and also drive changes in ANS. Such
changes can occur prior, during, after, or any combination thereof,
the seizure.
[0047] For example, disorders of the cardiovascular system and
other autonomic nervous system functions are often found in
patients with temporal lobe epilepsy (TLE). Traditional time and
frequency domain measures of heart rate (HR) variability (extracted
from ECG recordings) were lower in patients with TLE than in
controls (p<0.05). In addition, the power law slope (p<0.005)
and ApEn (p<0.05) were also reduced in TLE patients. The table
below details heart rate and measures of heart rate variability in
patients with TLE and control subjects:
TABLE-US-00002 Patients with Patients with All Control Measure/
refractory TLE well controlled TLE Patients subjects
pValue.dagger-dbl. variable (n = 9) (n = 25) (n = 44) (n = 4)
(Mann-Whitney) RRI (ms) 863 (103) 819 (112) 838 (109) 850 (71)
0.403 SDNN (ms) 154 (32) 158 (51) 156 (43) 177 (44) 0.039 VLF
(ms.sup.2) 1538 (762) 1749 (1005) 1658 (905) 3256 (1765) <0.001
LF (ms.sup.2) 905 (472) 1038 (507) 981 (491) 1901 (1308) 0.001 HF
(ms.sup.2) 604 (502) 628 (365) 618 (424) 1710 (2050) 0.011 ApEn
0.93 (0.21).dagger. 1.09 (0.32) 1.02 (0.29) 1.15 (0.21) 0.045
.alpha.1 1.22 (0.18) 1.17 (0.18) 1.19 (0.18) 1.16 (0.1) 0.292
.alpha.2 1.03 (9.0) 0.99 (7.64)* 1.01 (8.45) 1.01 (6.13) 0.824
Slope of HRV -1.32 (0.13) -1.37 (0.21) -1.35 (0.18) -1.20 (0.21)
0.002 Values are mean (SD); RRI, R-R Interval; SDNN, SD of all
RRIs; VLF, very low frequency; LF, low frequency; HF, high
frequency; ApEn, approximate entropy; .alpha.1, short term scaling
exponent; .alpha.2, long-term scaling exponent; *p = 0.037 compared
with the patients with refractory TLE; .dagger.p = 0.021 compared
to the patients with well controlled TLE; .dagger-dbl.all patients
compared with the control subjects.
[0048] Power spectral analysis of HR variability (power in ms 2) is
shown on the table above. The area under the spectral curve from
0.005 to 0.04 Hz represents VLF power, the area from 0.04 to 0.15
represents LF power, and the area from 0.15 to 0.4 Hz represents HF
power. Patients suffering from TLE show a typical suppression of
all the power spectral components of HR variability. RRI indicates
RR interval.
[0049] Examples of alerts indicating an imminent epileptic
attack(s)/seizure(s) could be set based on the data for patients
with refractory TLE, patients with well controlled TLE. As an
exemplary embodiment, an alert indicating an imminent epileptic
attack/seizure could be triggered when HF is at least 20% below the
mean expected HF (ms 2) for patients with refractory TLE, in this
case 480 ms 2 (versus expected 600). In another exemplary
embodiment, would be LF of at least 25% below the expected norm of
900, meaning 675 ms 2.
[0050] In some embodiments, an alert indicating an imminent
epileptic attack/seizure could be triggered when HF is between
20%-99% below the mean expected HF (ms 2) for patients with
refractory TLE. In some embodiments, an alert could be triggered
when HF is between 30%-99% below the mean expected HF (ms 2) for
patients with refractory TLE. In some embodiments, an alert could
be triggered when HF is between 40%-99% below the mean expected HF
(ms 2) for patients with refractory TLE. In some embodiments, an
alert could be triggered when HF is between 50%-99% below the mean
expected HF (ms 2) for patients with refractory TLE. In some
embodiments, an alert could be triggered when HF is between 60%-99%
below the mean expected HF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when HF is between
70%-99% below the mean expected HF (ms 2) for patients with
refractory TLE. In some embodiments, an alert could be triggered
when HF is between 80%-99% below the mean expected HF (ms 2) for
patients with refractory TLE. In some embodiments, an alert could
be triggered when HF is between 90%-99% below the mean expected HF
(ms 2) for patients with refractory TLE. In some embodiments, an
alert could be triggered when HF is between 20%-90% below the mean
expected HF (ms 2) for patients with refractory TLE. In some
embodiments, an alert could be triggered when HF is between 20%-80%
below the mean expected HF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when HF is between
20%-70% below the mean expected HF (ms 2) for patients with
refractory TLE. In some embodiments, an alert could be triggered
when HF is between 20%-60% below the mean expected HF (ms 2) for
patients with refractory TLE. In some embodiments, an alert
indicating an imminent epileptic attack/seizure could be triggered
when HF is between 20%-50% below the mean expected HF (ms 2) for
patients with refractory TLE. In some embodiments, an alert could
be triggered when HF is between 20%-40% below the mean expected HF
(ms 2) for patients with refractory TLE. In some embodiments, an
alert could be triggered when HF is between 20%-30% below the mean
expected HF (ms 2) for patients with refractory TLE. In some
embodiments, an alert could be triggered when HF is between 30%-90%
below the mean expected HF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when HF is between
40%-80% below the mean expected HF (ms 2) for patients with
refractory TLE. In some embodiments, an alert could be triggered
when HF is between 50%-70% below the mean expected HF (ms 2) for
patients with refractory TLE.
[0051] In some embodiments, an alert indicating an imminent
epileptic attack/seizure could be triggered when LF is between
25%-99% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
30%-99% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
40%-99% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
50%-99% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
60%-99% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
70%-99% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
80%-99% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
90%-99% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
25%-90% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
25%-80% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
25%-70% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
25%-60% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
25%-50% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
25%-40% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
25%-30% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
30%-90% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
40%-80% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
30%-90% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
40%-80% below expected LF (ms 2) for patients with refractory TLE.
In some embodiments, an alert could be triggered when LF is between
50%-70% below expected LF (ms 2) for patients with refractory
TLE.
[0052] In some embodiments, the sympathetic nervous system is one
of the two main divisions of the autonomic nervous system, the
other being the parasympathetic nervous system. The autonomic
nervous system functions to regulate the body's unconscious
actions. The sympathetic nervous system's primary process is to
stimulate the body's fight-or-flight response. It is, however,
constantly active at a basic level to maintain homeostasis. The
sympathetic nervous system is complementary to the parasympathetic
nervous system which stimulates the body to "rest-and-digest" or
"feed and breed". It increases during excitement and also with
physical or mental. The only organ that is purely innervated by the
sympathetic nervous system (and not affected by parasympathetic
activation) is the skin. In some embodiments, an increase in
sympathetic activation can be observed by monitoring subtle
electrical changes across the surface of the skin. In an exemplary
embodiment, during an epileptic seizure, an average amplitude of
EDA was 8.15 microSiemens (0.60-20.95), where the siemens (SI unit
symbol: S) is the unit of electric conductance, electric
susceptance and electric admittance in the International System of
Units (SI). In some embodiments, an alert would be triggered when
an EDA measurement exceeds 6 microsiemens. In some embodiments, a
combination of parameters such as hand or body movement, components
of HRV, EDA (electrodermal activity), or any combination thereof,
could be derived as combined factors in a linear or non-linear way
(using tools such as, but not limited to, neural network and factor
analysis).
[0053] In some embodiments, additional measurements such as, but
not limited to, skin conductivity could be used as part of a
trigger or alert mechanism. For example, EDA rises during epilepsy
seizures. In some embodiments, an alert indicating an imminent
epileptic attack/seizure could be triggered when an EDA measurement
rises between 10-99% compared with an expected EDA measurement. In
some embodiments, an alert could be triggered when an EDA
measurement rises between 20-99% compared with an expected EDA
measurement. In some embodiments, an alert could be triggered when
an EDA measurement rises between 30-99% compared with an expected
EDA measurement. In some embodiments, an alert could be triggered
when an EDA measurement rises between 40-99% compared with an
expected EDA measurement. In some embodiments, an alert could be
triggered when an EDA measurement rises between 50-99% compared
with an expected EDA measurement. In some embodiments, an alert
could be triggered when an EDA measurement rises between 60-99%
compared with an expected EDA measurement. In some embodiments, an
alert could be triggered when an EDA measurement rises between
70-99% compared with an expected EDA measurement. In some
embodiments, an alert could be triggered when an EDA measurement
rises between 80-99% compared with an expected EDA measurement. In
some embodiments, an alert could be triggered when an EDA
measurement rises between 90-99% compared with an expected EDA
measurement. In some embodiments, an alert could be triggered when
an EDA measurement rises between 10-90% compared with an expected
EDA measurement. In some embodiments, an alert could be triggered
when an EDA measurement rises between 10-80% compared with an
expected EDA measurement. In some embodiments, an alert could be
triggered when an EDA measurement rises between 10-70% compared
with an expected EDA measurement. In some embodiments, an alert
could be triggered when an EDA measurement rises between 10-60%
compared with an expected EDA measurement. In some embodiments, an
alert could be triggered when an EDA measurement rises between
10-50% compared with an expected EDA measurement. In some
embodiments, an alert could be triggered when an EDA measurement
rises between 10-40% compared with an expected EDA measurement. In
some embodiments, an alert could be triggered when an EDA
measurement rises between 10-30% compared with an expected EDA
measurement. In some embodiments, an alert could be triggered when
an EDA measurement rises between 10-20% compared with an expected
EDA measurement. In some embodiments, an alert could be triggered
when an EDA measurement rises between 20-90% compared with an
expected EDA measurement. In some embodiments, an alert could be
triggered when an EDA measurement rises between 30-80% compared
with an expected EDA measurement. In some embodiments, an alert
could be triggered when an EDA measurement rises between 40-70%
compared with an expected EDA measurement. In some embodiments, an
alert could be triggered when an EDA measurement rises between
50-60% compared with an expected EDA measurement.
[0054] In some embodiments, the system of the present invention is
configured to use, e.g., but not limited to, real time HRV obtained
from data captured from a wristband as at least one signal, and
generates an alert for a predicted epileptic seizure.
[0055] In some embodiments, the system can include parameters such
as, but not limited to, the disease background of the patient when
calculating the expected values of the HRV throughout the night. In
some embodiments, a correlation exists between suffering from
epilepsy and reduced HRV; specifically, an overall decline in HRV
in both epileptic and non-epileptic populations can occur, with a
greater decrease in participants with epilepsy.
Epilepsies
[0056] Epilepsies are a spectrum of brain disorders ranging from
severe, life-threatening and disabling, to benign disorders. In
epilepsy, the normal pattern of neuronal activity becomes
disturbed, causing strange sensations, emotions, and behavior. This
disturbed neuronal activity sometimes causes convulsions, muscle
spasms, and loss of consciousness. The epilepsies have many
possible causes and there are several types of seizures. Seizures
can be caused by any disruption to the normal pattern of neuron
activity. Examples of neuronal activity disruption are: illness,
brain damage, and abnormal brain development. Epilepsy can also
develop due to an abnormality in brain wiring, an imbalance of
nerve signaling chemicals (neurotransmitters), changes in brain
cell channels, or some combination of these and other factors.
Having a single seizure as the result of a high fever (called
febrile seizure) or head injury does not necessarily mean that a
person has epilepsy. For about 70 percent of those diagnosed with
epilepsy, seizures can be controlled with modern medicines and
surgical techniques.
[0057] In some embodiments, the present invention is focused on 30%
of a patient population diagnosed with epilepsy which suffers from
seizures that are not able to be controlled with modern medicines
and surgical techniques. In some embodiments, the present invention
is focused on those suffering from night seizures. In some
embodiments of the present invention, a population of patients
diagnosed with epilepsy is at risk for abnormally prolonged
seizures or sudden unexplained death. In some embodiments, the
present invention is a system that can predict an upcoming or
ongoing seizure and provide an alert of an ongoing seizure. In some
embodiments of the present invention, the seizure is a nocturnal
(night) seizure. In some embodiments of the present invention, the
occurrence of a night seizure can pose a risk on the life of the
patient. In some embodiments, the present invention identifies
abnormalities and changes in the heartbeat, heartbeat variability
and other changes in the period before and during epileptic
seizures.
[0058] In some embodiments of the present invention, in addition to
HRV and rapid, sudden hand or other body part movement, additional
parameters can be used for the prediction of an epileptic seizure
or at least create an alert once the epilepsy seizure occurs.
[0059] In some embodiments of the present invention, HRV is used to
detect autonomic dysfunction. In some embodiments of the present
invention, a dysfunction of autonomic nervous system is associated
with increased mortality after myocardial infarction in the general
population and also in patients with epileptic seizures. In some
embodiments of the present invention, HRV is categorized into high
frequency power (e.g., HF; 0.15-0.40 Hz) and low frequency power
(e.g. LF; 0.04-0.15 Hz), and both categorizations depend on
oscillatory frequency and development mechanism. In some
embodiments of the present invention, the LF component is
influenced by both parasympathetic and sympathetic regulation. In
some embodiments of the present invention, the HF component and
LF/(HF+LF) ratio in normalized units (LF %) reflect the extent of
vagal (parasympathetic) and sympathetic regulation of the heart,
respectively.
[0060] An embodiment of the present invention is an alert system,
which incorporates at least one of the following: 1) heart rate, 2)
HRV, 3) stress level and daily stressful and other
activities/events the user experienced, 4) food intake and
medication of the user and 5) the heart rate and HRV parameters of
the user. In an embodiment of the present invention, for each point
in time and in particular the night, the system calculates an
expected hand and body movement, expected heart rate and HRV, and
for extreme deviations from these values, the system creates an
epilepsy alert. In an embodiment of the present invention, a system
does not require a camera to view the movement of the body of the
user. In another embodiment of the present invention, a digital
camera (with or without infrared to assist in night viewing)
connected to a computer is added to the system, to detect movement.
In some embodiments of the present invention, sudden movement (that
is calculably more extreme than expected movements of the user
during the day or night) is used as an additional measurement to
detect seizures.
[0061] An embodiment of the present invention is shown in FIG. 3.
In the embodiment, a combination of a wristband (or armband, or
other wearable sensor) 710 worn by a user 720, which can
communicate by a communication standard such as Bluetooth 730 with
a mobile device such as an iPhone 740. In an embodiment of the
present invention, an application resides on the mobile device 740
and captures the biosignal of the heart rate and HRV from the
wristband 710. In another embodiment, additional biosignals
captured from the body of the user from the sensors on the
wristband including, but not limited to, tremor, blood oxygen,
galvanic response, and skin temperature.
[0062] An embodiment of the present invention is also shown in FIG.
4. In an embodiment, HRV is configured to be calculated at the
mobile device if the frequency of the beat to beat heart sampling
is sufficiently high, for example at 108 hz. In another embodiment,
information from an application can be sent to a Data Center 750
where Big Data analysis is configured to be managed. In an
embodiment, data is managed by comparison to other user data,
benchmarking to historical data, back-testing, storage, routing of
data to medical personnel is conducted.
[0063] In an embodiment of the present invention, a sudden change
in HRV or at one of its components (e.g., the LH or HF components)
is an indication of a forthcoming epileptic seizure. In an
embodiment of the present invention, an alert is configured to
trigger an alarm on the mobile phone. In another embodiment, the
present invention alerts the user to wake-up. In another
embodiment, the present invention sends at least one alert to a
medical team or a family member of the user.
[0064] An embodiment of the present invention is shown in FIG. 5.
In an embodiment, an initial setting up phase 9.1, where the user
configures his preference set, containing his medications,
including dosing, morning medication. In another embodiment, at
step 9.2. the user enters his last food intake before going to
sleep, as well as the information related to current stress level
(if, for example, the wrist band was not worn during the day and
the information was not captured during the day by the system
already), and events that may have been contributing to stress
level throughout the day (such events may also have been documented
by the user on the system during the day. In another embodiment, at
stage 9.3, information from the wristband is continuously analyzed.
In another embodiment, such information includes multi-parameters
from at least one of the following measurements: beat to beat heart
rate, HRV and its components, oxygen level, skin temperature, hand
and body movement (as captured by the accelerometer), galvanic skin
response. In another embodiment, such data is analyzed for changes
versus what would have been expected for the same time during the
night sleep for the same user when compared to the benchmark on the
data base located at the mobile device 740 and/or the data center
750 and/or the cpu level located on the wrist band 710. In another
embodiment, a comparison of the calculated expected values versus
the actual values is accounted. In another embodiment, the prior
information known about the user, such as the food eaten in the
meal prior to going to sleep as tested prior to going to sleep and
in the tests measured on the day preceding to it are accounted.
[0065] In another embodiment, when according to the comparison
system 9.5 there is a significant change from what would have been
expected, an alert system would be triggered, to wake up the person
9.6.1, to alert the family, 9.6.2 and/or the medical team
9.6.3.
[0066] In another embodiment of the present invention, the triggers
for an alarm are configured to be adjusted based on the lifestyle
and habits of the user. In an embodiment, the user could enter the
food the user eats before going to sleep, medications and other
personal settings that could affect the likelihood and timing of an
epileptic attack.
[0067] In an embodiment of the present invention, the amount and
type of food and medications prior to going to sleep will have an
impact on the probability of epilepsy and the time during sleep, if
at all, of an epilepsy event to occur. In an embodiment, additional
events on the day prior to the night sleep influence the likelihood
of epilepsy to occur. In an embodiment, levels of stress are
measured by the wristband using HRV previously measured (during the
preceding day(s)), as captured by the application. In an
embodiment, the higher the level of stress, the higher the
likelihood for occurrence of an event of epilepsy.
Illustrative Operating Environments
[0068] FIG. 1 illustrates one embodiment of an environment in which
the system of the present invention may operate. However, not all
of these components may be required to practice the invention, and
variations in the arrangement and type of the components may be
made without departing from the spirit or scope of the present
invention. In some embodiments, the system and method may include a
large number of members and/or concurrent transactions. In other
embodiments, the system and method are based on a scalable computer
and network architecture that incorporates varies strategies for
assessing the data, caching, searching, and database connection
pooling. An example of the scalable architecture is an architecture
that is capable of operating multiple servers.
[0069] In embodiments, members of the computer system 102-104
include virtually any computing device capable of receiving and
sending a message over a network, such as network 105, to and from
another computing device, such as servers 106 and 107, each other,
and the like. In embodiments, the set of such devices includes
devices that typically connect using a wired communications medium
such as personal computers, multiprocessor systems,
microprocessor-based or programmable consumer electronics, network
PCs, and the like. In embodiments, the set of such devices also
includes devices that typically connect using a wireless
communications medium such as cell phones, smart phones, pagers,
walkie talkies, radio frequency (RF) devices, infrared (IR)
devices, CBs, integrated devices combining one or more of the
preceding devices, or virtually any mobile device, and the like.
Similarly, in embodiments, client devices 102-104 are any device
that is capable of connecting using a wired or wireless
communication medium such as a PDA, POCKET PC, wearable computer,
and any other device that is equipped to communicate over a wired
and/or wireless communication medium.
[0070] In embodiments, each member device within member devices
102-104 may include a browser application that is configured to
receive and to send web pages, and the like. In embodiments, the
browser application may be configured to receive and display
graphics, text, multimedia, and the like, employing virtually any
web based language, including, but not limited to Standard
Generalized Markup Language (SMGL), such as HyperText Markup
Language (HTML), a wireless application protocol (WAP), a Handheld
Device Markup Language (HDML), such as Wireless Markup Language
(WML), WMLScript, XML, JavaScript, and the like. In some
embodiments, programming may include either Java, .Net, QT, C, C++
or other suitable programming language.
[0071] In embodiments, member devices 102-104 may be further
configured to receive a message from another computing device
employing another mechanism, including, but not limited to email,
Short Message Service (SMS), Multimedia Message Service (MMS),
instant messaging (IM), internet relay chat (IRC), mIRC, Jabber,
and the like or a Proprietary protocol.
[0072] In embodiments, network 105 may be configured to couple one
computing device to another computing device to enable them to
communicate. In some embodiments, network 105 may be enabled to
employ any form of computer readable media for communicating
information from one electronic device to another. Also, in
embodiments, network 105 may include a wireless interface, and/or a
wired interface, such as the Internet, in addition to local area
networks (LANs), wide area networks (WANs), direct connections,
such as through a universal serial bus (USB) port, other forms of
computer-readable media, or any combination thereof. In
embodiments, on an interconnected set of LANs, including those
based on differing architectures and protocols, a router may act as
a link between LANs, enabling messages to be sent from one to
another.
[0073] Also, in some embodiments, communication links within LANs
typically include twisted wire pair or coaxial cable, while
communication links between networks may utilize analog telephone
lines, full or fractional dedicated digital lines including T1, T2,
T3, and T4, Integrated Services Digital Networks (ISDNs), Digital
Subscriber Lines (DSLs), wireless links including satellite links,
or other communications links known to those skilled in the art.
Furthermore, in some embodiments, remote computers and other
related electronic devices could be remotely connected to either
LANs or WANs via a modem and temporary telephone link. In essence,
in some embodiments, network 105 includes any communication method
by which information may travel between client devices 102-104, and
servers 106 and 107.
[0074] FIG. 2 shows another exemplary embodiment of the computer
and network architecture that supports the method and system. The
member devices 202a, 202b thru 202n shown each at least includes a
computer-readable medium, such as a random access memory (RAM) 208
coupled to a processor 210 or FLASH memory. The processor 210 may
execute computer-executable program instructions stored in memory
208. Such processors comprise a microprocessor, an ASIC, and state
machines. Such processors comprise, or may be in communication
with, media, for example computer-readable media, which stores
instructions that, when executed by the processor, cause the
processor to perform the steps described herein. Embodiments of
computer-readable media may include, but are not limited to, an
electronic, optical, magnetic, or other storage or transmission
device capable of providing a processor, such as the processor 210
of client 202a, with computer-readable instructions. Other examples
of suitable media may include, but are not limited to, a floppy
disk, CD-ROM, DVD, magnetic disk, memory chip, ROM, RAM, an ASIC, a
configured processor, all optical media, all magnetic tape or other
magnetic media, or any other medium from which a computer processor
can read instructions. Also, various other forms of
computer-readable media may transmit or carry instructions to a
computer, including a router, private or public network, or other
transmission device or channel, both wired and wireless. The
instructions may comprise code from any computer-programming
language, including, for example, C, C++, C#, Visual Basic, Java,
Python, Perl, and JavaScript.
[0075] Member devices 202a-n may also comprise a number of external
or internal devices such as a mouse, a CD-ROM, DVD, a keyboard, a
display, or other input or output devices. Examples of client
devices 202a-n may be personal computers, digital assistants,
personal digital assistants, cellular phones, mobile phones, smart
phones, pagers, digital tablets, laptop computers, Internet
appliances, and other processor-based devices. In general, a client
device 202a may be any type of processor-based platform that is
connected to a network 206 and that interacts with one or more
application programs. Client devices 202a-n may operate on any
operating system capable of supporting a browser or browser-enabled
application, such as Microsoft.TM., Windows.TM., or Linux. The
client devices 202a-n shown may include, for example, personal
computers executing a browser application program such as Microsoft
Corporation's Internet Explorer.TM., Apple Computer, Inc.'s
Safari.TM., Mozilla Firefox, and Opera. Through the client devices
202a-n, users, 212a-n communicate over the network 206 with each
other and with other systems and devices coupled to the network
206. As shown in FIG. 1B, server devices 204 and 213 may be also
coupled to the network 206.
[0076] In some embodiments, the term "mobile electronic device" may
refer to any portable electronic device that may or may not be
enabled with location tracking functionality. For example, a mobile
electronic device can include, but is not limited to, a mobile
phone, Personal Digital Assistant (PDA), Blackberry.TM., Pager,
Smartphone, or any other reasonable mobile electronic device. For
ease, at times the above variations are not listed or are only
partially listed, this is in no way meant to be a limitation.
[0077] In some embodiments, the terms "proximity detection,"
"locating," "location data," "location information," and "location
tracking" as used herein may refer to any form of location tracking
technology or locating method that can be used to provide a
location of a mobile electronic device, such as, but not limited
to, at least one of location information manually input by a user,
such as, but not limited to entering the city, town, municipality,
zip code, area code, cross streets, or by any other reasonable
entry to determine a geographical area; Global Positions Systems
(GPS); GPS accessed using Bluetooth.TM.; GPS accessed using any
reasonable form of wireless and/or non-wireless communication;
WiFi.TM. server location data; Bluetooth.TM. based location data;
triangulation such as, but not limited to, network based
triangulation, WiFi.TM. server information based triangulation,
Bluetooth.TM. server information based triangulation; Cell
Identification based triangulation, Enhanced Cell Identification
based triangulation, Uplink-Time difference of arrival (U-TDOA)
based triangulation, Time of arrival (TOA) based triangulation,
Angle of arrival (AOA) based triangulation; techniques and systems
using a geographic coordinate system such as, but not limited to,
longitudinal and latitudinal based, geodesic height based,
cartesian coordinates based; Radio Frequency Identification such
as, but not limited to, Long range RFID, Short range RFID; using
any form of RFID tag such as, but not limited to active RFID tags,
passive RFID tags, battery assisted passive RFID tags; or any other
reasonable way to determine location. For ease, at times the above
variations are not listed or are only partially listed, this is in
no way meant to be a limitation.
[0078] In some embodiments, near-field wireless communication (NFC)
can represent a short-range wireless communications technology in
which NFC-enabled devices are "swiped," "bumped," "tap" or
otherwise moved in close proximity to communicate. In some
embodiments, NFC could include a set of short-range wireless
technologies, typically requiring a distance of 10 cm or less.
[0079] In some embodiments, NFC may operate at 13.56 MHz on ISO/IEC
18000-3 air interface and at rates ranging from 106 kbit/s to 424
kbit/s. In some embodiments, NFC can involve an initiator and a
target; the initiator actively generates an RF field that can power
a passive target. In some embodiment, this can enable NFC targets
to take very simple form factors such as tags, stickers, key fobs,
or cards that do not require batteries. In some embodiments, NFC
peer-to-peer communication can be conducted when a plurality of
NFC-enable devices within close proximity of each other.
[0080] For purposes of the instant description, the terms "cloud,"
"Internet cloud," "cloud computing," "cloud architecture," and
similar terms correspond to at least one of the following: (1) a
large number of computers connected through a real-time
communication network (e.g., Internet); (2) providing the ability
to run a program or application on many connected computers (e.g.,
physical machines, virtual machines (VMs)) at the same time; (3)
network-based services, which appear to be provided by real server
hardware, and are in fact served up by virtual hardware (e.g.,
virtual servers), simulated by software running on one or more real
machines (e.g., allowing to be moved around and scaled up (or down)
on the fly without affecting the end user). In some embodiments,
the instant invention offers/manages the cloud
computing/architecture as, but not limiting to: infrastructure a
service (IaaS), platform as a service (PaaS), and software as a
service (SaaS). FIGS. 8 and 9 illustrate schematics of exemplary
implementations of the cloud computing/architecture.
[0081] Of note, the embodiments described herein may, of course, be
implemented using any appropriate computer system hardware and/or
computer system software. In this regard, those of ordinary skill
in the art are well versed in the type of computer hardware that
may be used (e.g., a mainframe, a mini-computer, a personal
computer ("PC"), a network (e.g., an intranet and/or the
internet)), the type of computer programming techniques that may be
used (e.g., object oriented programming), and the type of computer
programming languages that may be used (e.g., C++, Basic, AJAX,
Javascript). The aforementioned examples are, of course,
illustrative and not restrictive.
[0082] In some embodiments, the present invention provides a method
of epileptic-directed treatment for an epileptic seizure, including
delivering an alert to a user and/or a third party (e.g., but not
limited to, a medical professional, a family member, etc.) of an
imminent epileptic seizure so as to allow the user and/or third
party to administer a medication to treat the user to reduce the
occurrence and/or severity of the epileptic seizure by between
10-99% (e.g., but not limited to, 10%, 20%, 30%, 40%, 50%, 60%,
70%, 80%, 90%, 95%, etc.) In some embodiments, epileptic-directed
medications such as, but not limited to, Dilantin/phenytek,
phenobarbital, tegretol, mysoline, zarontin, depakene, Depakote,
valium, tranzene, klonopin, felbatol, gabitril, keppra, lamictal,
lyrica, Neurontin, Topamax, trileptal, zonegran, or any combination
thereof, are administered to a user (after the alert is delivered
to the user) so as to treat the imminent epileptic attack. In some
embodiments, Dilantin is administered to a user orally at between
100 mg-400 mg a dose. In some embodiments, phenobarbital is
administered to a user orally, intramuscularly (IM), or intravenous
(IV) at between 30 to 120 mg/day. In some embodiments, tegretol is
administered to a user orally at between 100-200 b.i.d. (two times
a day) or 0.5-1 teaspoon q.i.d. (single dose) for suspension
(200-400 mg/day). In some embodiments, mysoline is administered to
a user orally at between 50 to 250 mg t.i.d. In some embodiments,
zarontin is administered to a user orally at between 250 mg to 500
mg a day. In some embodiments, depakene/valproic acid is
administered to a user orally at between 250 mg-1.25 mg a day. In
some embodiments, depakote is administered to a user orally at
between 10-60 mg/kg/day. In some embodiments, valium is
administered to a user orally at between 2 mg-10 mg, 3 or 4 times
daily. In some embodiments, tranzene is administered to a user
orally at between 15 to 90 mg in divided doses. In some
embodiments, klonopin is administered to a user orally at between
0.5 mg to 1.5 mg/day. In some embodiments, felbatol is administered
to a user orally at between 1200-3600 mg/day. In some embodiments,
gabitril is administered to a user orally at between 2-16 mg daily.
In some embodiments, keppra is administered to a user orally at
between 35-3000 mg daily. In some embodiments, lamictal is
administered to a user orally at between 25 mg/day-500 mg/day. In
some embodiments, lyrica is administered to a user orally at
between 150-600 mg/day. In some embodiments, Neurontin is
administered to a user orally at between 100-3600 mg/day. In some
embodiments, Topamax is administered to a user orally at between
50-400 mg/day (administered in two doses). In some embodiments,
trileptal is administered to a user orally at between 600
mg/day-1200 mg/day. In some embodiments, zonegran is administered
to a user orally at between 100-600 mg/day.
[0083] In some embodiments, the present invention provides a method
of epileptic-directed treatment for an epileptic seizure, including
delivering an alert to a user and/or a third party (e.g., but not
limited to, a medical professional, a family member, etc.) of an
imminent epileptic seizure so as to allow the user and/or third
party to administer a breathing/relaxation exercise, e.g.,
breathing normalization and/or progressive relaxation to reduce the
occurrence or severity of the imminent epileptic seizure. In some
embodiments, electrotherapy can be administered to a user to treat
an imminent epileptic attack.
[0084] In some embodiments, the instant invention provides for a
computer system, including: a) at least one server having software
stored on a non-transient computer readable medium; where, upon
execution of the software, the at least one server is at least
configured to: i) receiving, an input from a user, where the input
includes user data consisting of: food intake of the user,
medication intake by the user, stress related events in the
preceding day, or any combination thereof; ii) receiving, in
real-time, physiological data representative of at least one
physiological measurement of at least one physiological
characteristic of the user, where the at least one physiological
characteristic is selected from the group consisting of: heart
rate, heart rate variability, oxygen saturation, temperature,
galvanic skin response, or any combination thereof; iii) comparing,
in real-time, the at least one physiological measurement of the
user to at least one pre-determined physiological value associated
with the at least one physiological characteristic retrieved from
at least one database; iv) based on the comparing, determining, in
real-time, that a difference between the at least one physiological
measurement of the user and the at least one pre-determined
physiological value is: a) higher than a predetermined threshold
value, or b) smaller than the predetermined threshold value, and
then: v) generating, in real-time, at least one alert when the at
least one pre-determined physiological value is higher than the
predetermined threshold value; vi) transmitting, in real-time, the
at least one alert to at least one of: the user, at least one
family member, at least one medical practitioner, or any
combination thereof; and vii) when the at least one pre-determined
physiological value is smaller than the predetermined threshold
value, causing to continue measuring, in real-time, the at least
one physiological characteristic of the user.
[0085] In some embodiments, the instant invention provides for a
computer method, including: i) receiving, an input from a user or
from his medical record, where the input comprises user data
consisting of: food intake of the user, stress related events in
the preceding day, medication intake by the user (including, for
example, but not limited to, insulin), medical measurements
(including glucose reading), or any combination thereof; ii)
receiving, in real-time, physiological data representative of at
least one physiological measurement of at least one physiological
characteristic of the user, where the at least one physiological
characteristic is selected from the group consisting of: heart
rate, heart rate variability, oxygen saturation, temperature,
galvanic skin response, or any combination thereof; iii) comparing,
in real-time, the at least one physiological measurement of the
user to at least one pre-determined physiological value associated
with the at least one physiological characteristic retrieved from
at least one database; iv) based on the comparing, determining, in
real-time, that a difference between the at least one physiological
measurement of the user and the at least one pre-determined
physiological value is: a) higher than a predetermined threshold
value, or b) smaller than the predetermined threshold value, and
then: v) generating, in real-time, at least one alert when the at
least one pre-determined physiological value is higher than the
predetermined threshold value; vi) transmitting, in real-time, the
at least one alert to at least one of: the user, at least one
family member, at least one medical practitioner, or any
combination thereof; and vii) when the at least one pre-determined
physiological value is smaller than the predetermined threshold
value, causing to continue measuring, in real-time, the at least
one physiological characteristic of the user.
[0086] In some embodiments, the instant invention provides for a
computer system, including: a) at least one server having software
stored on a non-transient computer readable medium; where, upon
execution of the software, the at least one server is at least
configured to: i) receiving, in real-time, an input from a user,
where the input includes user data consisting of: food intake of
the user, medical measurements by the user (such as, but not
limited to, blood pressure reading and/or glucose reading),
medication intake by the user, or any combination thereof; ii)
receiving, in real-time, physiological data representative of at
least one physiological measurement of at least one physiological
characteristic of the user, where the at least one physiological
characteristic is selected from the group consisting of: heart
rate, heart rate variability, oxygen saturation, temperature,
galvanic skin response, or any combination thereof; iii) comparing,
in real-time, the at least one physiological measurement of the
user to at least one pre-determined physiological value associated
with the at least one physiological characteristic retrieved from
at least one database; iv) based on the comparing, determining, in
real-time, that a difference between the at least one physiological
measurement of the user and the at least one pre-determined
physiological value is: a) higher than a predetermined threshold
value, or b) smaller than the predetermined threshold value, and
then: v) generating, in real-time, at least one alert when the at
least one pre-determined physiological value is higher than the
predetermined threshold value; vi) transmitting, in real-time, the
at least one alert to at least one of: the user, at least one
family member, at least one medical practitioner, or any
combination thereof; and vii) when the at least one pre-determined
physiological value is smaller than the predetermined threshold
value, causing to continue measuring, in real-time, the at least
one physiological characteristic of the user.
[0087] In some embodiments, the instant invention provides for a
computer method, including: i) receiving, in real-time, an input
from a user, where the input comprises user data consisting of:
food intake of the user, medication intake by the user, recent
medical readings (such as, but not limited to, glucose reading or
blood pressure and the readings taken within, e.g., but not limited
to, between 1 second and 1 hour (e.g., 1 second, 1 minute, 5
minutes, 10 minutes, 15 minutes, etc.)) or any combination thereof;
ii) receiving, in real-time, physiological data representative of
at least one physiological measurement of at least one
physiological characteristic of the user, where the at least one
physiological characteristic is selected from the group consisting
of: heart rate, low frequency heart rate variability, high
frequency heart rate variability, oxygen saturation, temperature,
galvanic skin response, or any combination thereof; iii) comparing,
in real-time, the at least one physiological measurement of the
user to at least one pre-determined physiological value associated
with the at least one physiological characteristic retrieved from
at least one database; iv) based on the comparing, determining, in
real-time, that a difference between the at least one physiological
measurement of the user and the at least one pre-determined
physiological value is: a) higher than a predetermined threshold
value, or b) smaller than the predetermined threshold value, and
then: v) generating, in real-time, at least one alert when the at
least one pre-determined physiological value is higher than the
predetermined threshold value; vi) transmitting, in real-time, the
at least one alert to at least one of: the user, at least one
family member, at least one medical practitioner, or any
combination thereof; and vii) when the at least one pre-determined
physiological value is smaller than the predetermined threshold
value, causing to continue measuring, in real-time, the at least
one physiological characteristic of the user.
[0088] An embodiment of the present invention is a
computer-implemented method, comprising: receiving, by a
specifically programed processing computer system, from an
electronic monitoring system, at least two of the following: i) a
first data from the electronic monitoring system, wherein the first
data from the electronic monitoring system is selected from the
group consisting of: a first heart beat, a first heart beat
variability, a first low frequency heart beat variability, a first
high frequency heart beat variability, a first level of movement,
and a first blood saturation level, and ii) a second data from the
electronic monitoring system, wherein the second data from the
electronic monitoring system is selected from the group consisting
of: a second heart beat, a second heart beat variability, a second
low frequency heart beat variability, a second high frequency heart
beat variability, a second level of movement, and second blood
saturation level; comparing the first data from the electronic
monitoring system to the second data from the electronic monitoring
system, wherein the electronic monitoring system identifies at
least one deviation of a user, wherein the user is patient
diagnosed with epilepsy; sending, by the specifically programed
processing computer system, at least one alert to at least one
designated responder, wherein the at least one designated responder
is selected from the group consisting of: a member of a medical
team and a member of the family; generating, in response to the
receiving the alert by the specifically programed processing
computer system, a notification to the at least one designated
responder; sending, by the specifically programed processing
computer system, the notification to the at least one designated
responder; receiving, by the at least one designated responder, the
notification; wherein the at least one designated responder
receives the notification by the specifically programed processing
computer system.
[0089] In some embodiments, the instant invention provides for a
computer system, including: a) at least one server having software
stored on a non-transient computer readable medium; where, upon
execution of the software, the at least one server is at least
configured to: i) receiving, in real-time, physiological data
representative of a first physiological measurement of at least one
physiological characteristic of the user, wherein the at least one
physiological characteristic is selected from the group consisting
of: heart rate, heart rate variability, oxygen saturation,
temperature, hand movement, galvanic skin response, or any
combination thereof; ii) receiving, in real-time, physiological
data representative of a second physiological measurement of at
least one physiological characteristic of the user, wherein the at
least one physiological characteristic is selected from the group
consisting of: heart rate, heart rate variability, oxygen
saturation, temperature, hand movement, galvanic skin response, or
any combination thereof; iii) comparing, in real-time, the first
physiological measurement of the user to the second physiological
measurement of the user; iv) based on the comparing, determining,
in real-time, that a difference between the first physiological
measurement of the user and the second physiological measurement
is: a) higher than a predetermined threshold value, or b) smaller
than the predetermined threshold value, and then: v) generating, in
real-time, at least one alert when the at least one pre-determined
physiological value is higher than the predetermined threshold
value; vi) transmitting, in real-time, the at least one alert to at
least one of: the user, at least one family member, at least one
medical practitioner, or any combination thereof; and vii) when the
at least one pre-determined physiological value is smaller than the
predetermined threshold value, causing to continue measuring, in
real-time, the at least one physiological characteristic of the
user.
[0090] In some embodiments, the instant invention provides for a
computer method, including: i) receiving, in real-time,
physiological data representative of a first physiological
measurement of at least one physiological characteristic of the
user, wherein the at least one physiological characteristic is
selected from the group consisting of: heart rate, heart rate
variability, oxygen saturation, temperature, hand movement,
galvanic skin response, or any combination thereof; ii) receiving,
in real-time, physiological data representative of a second
physiological measurement of at least one physiological
characteristic of the user, wherein the at least one physiological
characteristic is selected from the group consisting of: heart
rate, heart rate variability, oxygen saturation, temperature, hand
movement, galvanic skin response, or any combination thereof; iii)
comparing, in real-time, the first physiological measurement of the
user to the second physiological measurement of the user; iv) based
on the comparing, determining, in real-time, that a difference
between the first physiological measurement of the user and the
second physiological measurement is: a) higher than a predetermined
threshold value, or b) smaller than the predetermined threshold
value, and then: v) generating, in real-time, at least one alert
when the at least one pre-determined physiological value is higher
than the predetermined threshold value; vi) transmitting, in
real-time, the at least one alert to at least one of: the user, at
least one family member, at least one medical practitioner, or any
combination thereof; and vii) when the at least one pre-determined
physiological value is smaller than the predetermined threshold
value, causing to continue measuring, in real-time, the at least
one physiological characteristic of the user.
[0091] In some embodiments, the instant invention provides for a
method of treatment, including: when at least one alert generated
by at least one wearable computing device is received by a user,
administering an effective amount of an epileptic-directed
treatment to the user so as to reduce a severity or occurrence of
an imminent epileptic seizure, where the epileptic-directed
treatment is selected from the group consisting of an
epileptic-directed medication, electrotherapy, relaxation therapy,
and breathing therapy, where the at least one alert is generated
regarding at least one physiological condition; where the at least
one alert is generated when a measurement of the at least one
physiological condition is higher than at least one predetermined
threshold measurement, where the at least one physiological
condition of the user is selected from the group consisting of:
heart rate, heart rate variability, oxygen saturation, PPG signal,
temperature, hand movement, galvanic skin response, or any
combination thereof, where at least one alert is transmitted to at
least one of: the user, at least one family member, at least one
medical practitioner, or any combination thereof, and where, when
the measurement of the at least one physiological condition is
smaller than the predetermined threshold measurement, continuing to
measure the at least one physiological condition of the user. In
some embodiments, the at least one alert is further generated when
a first physiological measurement is compared to a second
physiological measurement, the second physiological measurement is
selected from the group consisting of: heart rate, heart rate
variability, oxygen saturation, temperature, hand movement,
galvanic skin response, PPG signal, or any combination thereof, the
at least one alert is generated when a difference between the first
physiological measurement of the user and the second physiological
measurement is higher than a predetermined threshold value.
[0092] While a number of embodiments of the present invention have
been described, it is understood that these embodiments are
illustrative only, and not restrictive, and that many modifications
may become apparent to those of ordinary skill in the art. Further
still, the various steps may be carried out in any desired order
(and any desired steps may be added and/or any desired steps may be
eliminated).
* * * * *