U.S. patent application number 15/911748 was filed with the patent office on 2018-09-13 for anti-mesothelin antibodies and uses thereof. This patent application is currently assigned to Bayer Intellectual Property GmbH. The applicant listed for this patent is Bayer Intellectual Property GmbH. Invention is credited to Tara HEITNER, Antje KAHNERT, David LIGHT, Renate PARRY, Noboru SATOZAWA, Doug SCHNEIDER, Ulrike SCHUBERT, Stefan STEIDL.
Application Number | 20180258181 15/911748 |
Document ID | / |
Family ID | 40351874 |
Filed Date | 2018-09-13 |
United States Patent Application | 20180258181 |
Kind Code | A1 |
KAHNERT; Antje ; et al. | September 13, 2018 |
The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
Inventors: | KAHNERT; Antje; (Wuppertal, DE) ; LIGHT; David; (Guilford, CT) ; SCHNEIDER; Doug; (Lafayette, CA) ; PARRY; Renate; (Oakland, CA) ; SATOZAWA; Noboru; (Berlin, DE) ; HEITNER; Tara; (Chiba, JP) ; STEIDL; Stefan; (Kopenhagen, DK) ; SCHUBERT; Ulrike; (Munchen, DE) | ||||||||||
Applicant: |
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Assignee: | Bayer Intellectual Property
GmbH Monheim DE |
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Family ID: | 40351874 | ||||||||||
Appl. No.: | 15/911748 | ||||||||||
Filed: | March 5, 2018 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
14645411 | Mar 11, 2015 | |||
15911748 | ||||
12744849 | Oct 20, 2010 | 9023351 | ||
PCT/EP2008/009756 | Nov 19, 2008 | |||
14645411 | ||||
61004378 | Nov 26, 2007 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | A61P 1/18 20180101; A61P 15/00 20180101; C07K 2317/21 20130101; C07K 2317/56 20130101; A61P 35/00 20180101; C07K 2317/77 20130101; C07K 2317/92 20130101; A61P 15/08 20180101; A61P 37/04 20180101; A61P 11/00 20180101; C07K 16/30 20130101; C07K 2317/24 20130101 |
International Class: | C07K 16/30 20060101 C07K016/30 |
Sequence CWU 1
1
371110PRTHomo sapiens 1Gly Tyr Ser Phe Thr Asn Tyr Trp Ile Gly 1 5
10 210PRTHomo sapiens 2Gly Phe Thr Phe Ser Asp Tyr Ala Met Ser 1 5
10 310PRTHomo sapiens 3Gly Tyr Thr Phe Thr Gly Asn Tyr Ile Asn 1 5
10 410PRTHomo sapiens 4Gly Gly Thr Phe Ser Ser Tyr Tyr Phe Ser 1 5
10 510PRTHomo sapiens 5Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly 1 5
10 610PRTHomo sapiens 6Gly Gly Ser Ile Ser Asn Tyr Tyr Trp Ser 1 5
10 710PRTHomo sapiens 7Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser 1 5
10 810PRTHomo sapiens 8Gly Phe Thr Phe Ser Asn Ser Trp Met Ser 1 5
10 910PRTHomo sapiens 9Gly Gly Thr Phe Ser Asn Tyr Ser Ile Ser 1 5
10 1010PRTHomo sapiens 10Gly Tyr Thr Phe Thr Ser Tyr Ala Leu His 1
5 10 1112PRTHomo sapiens 11Gly Asp Ser Val Ser Ser Arg Ser Ala Ala
Trp Gly 1 5 10 1210PRTHomo sapiens 12Gly Gly Thr Phe Ser Asn Tyr
Ser Leu His 1 5 10 1310PRTHomo sapiens 13Gly Phe Thr Phe Ser Ser
Tyr Ala Met Asn 1 5 10 1410PRTHomo sapiens 14Gly Tyr Thr Phe Thr
Ile Tyr Asp Met His 1 5 10 1512PRTHomo sapiens 15Gly Asp Ser Val
Ser Ser Asn Ser Ala Ala Trp Gly 1 5 10 169PRTHomo sapiens 16Gly Tyr
Ser Phe Asn Thr Ser Trp Ile 1 5 1712PRTHomo sapiens 17Gly Asp Ser
Val Ser Ser Asn Ser Ala Ala Trp Ser 1 5 10 1810PRTHomo sapiens
18Gly Tyr Ser Phe Thr Thr Tyr Trp Ile Gly 1 5 10 1912PRTHomo
sapiens 19Gly Asp Ser Val Ser Ser Asn Ser Ala Ser Trp Ser 1 5 10
2010PRTHomo sapiens 20Gly Phe Thr Phe Ser Thr Tyr Ala Met Ser 1 5
10 2110PRTHomo sapiens 21Gly Phe Thr Phe Ser Arg Tyr Ala Ile Ser 1
5 10 2210PRTHomo sapiens 22Gly Gly Thr Phe Ser Ser Tyr Tyr Ile Ser
1 5 10 2310PRTHomo sapiens 23Gly Gly Thr Phe Ser Ser His Ala Ile
Ser 1 5 10 2412PRTHomo sapiens 24Gly Asp Ser Val Ser Ser Asn Thr
Ala Ala Trp Ser 1 5 10 2512PRTHomo sapiens 25Gly Phe Ser Leu Ser
Ser Ser Gly Val Gly Val Ser 1 5 10 2612PRTHomo sapiens 26Gly Asp
Ser Val Ser Ser Ser Ser Ala Ala Trp Ser 1 5 10 279PRTHomo sapiens
27Gly Phe Thr Phe Ser Ser His Tyr Ser 1 5 2810PRTHomo sapiens 28Gly
Gly Thr Phe Ser Asn Tyr Thr Ile Ser 1 5 10 299PRTHomo sapiens 29Gly
Phe Thr Phe Ser Ser Tyr Tyr Ser 1 5 3010PRTHomo sapiens 30Gly Phe
Thr Phe Ser Asn Tyr Gly Ile His 1 5 10 3120PRTHomo sapiens 31Trp
Met Gly Val Ile Met Pro Ser Asp Ser Tyr Thr Arg Tyr Ser Pro 1 5 10
15 Ser Phe Gln Gly 20 3220PRTHomo sapiens 32Trp Met Gly Phe Ile Trp
Pro Val Asp Ser Trp Thr Gln Tyr Ser Pro 1 5 10 15 Ser Phe Gln Gly
20 3320PRTHomo sapiens 33Trp Met Gly Ile Ile Trp Pro Ile Asp Ser
Phe Thr Gln Tyr Ser Pro 1 5 10 15 Ser Phe Gln Gly 20 3420PRTHomo
sapiens 34Trp Val Ser Ala Ile Met Tyr Asp Ser Ser Ser Thr Phe Tyr
Ala Asp 1 5 10 15 Ser Val Lys Gly 20 3520PRTHomo sapiens 35Trp Met
Gly Ile Ile Asn Pro His Gly Gly Asp Thr Lys Tyr Ala Gln 1 5 10 15
Lys Phe Gln Gly 20 3620PRTHomo sapiens 36Trp Met Gly Ile Ile Asn
Pro Thr Lys Gly Trp Thr Leu Tyr Ala Gln 1 5 10 15 Lys Phe Gln Gly
20 3720PRTHomo sapiens 37Trp Met Gly Ile Ile Asn Pro Thr Lys Gly
Trp Thr Leu Tyr Ala Gln 1 5 10 15 Lys Phe Gln Gly 20 3820PRTHomo
sapiens 38Trp Met Gly Gly Ile Ile Pro Lys Phe Gly Ser Ala Asn Tyr
Ala Gln 1 5 10 15 Lys Phe Gln Gly 20 3920PRTHomo sapiens 39Trp Met
Gly Ile Ile Asp Pro Gly Asp Ser Arg Thr Arg Tyr Ser Pro 1 5 10 15
Ser Phe Gln Gly 20 4019PRTHomo sapiens 40Trp Ile Gly Glu Ile Tyr
His Ser Gly Gly Thr Tyr Tyr Asn Pro Ser 1 5 10 15 Leu Lys Gly
4120PRTHomo sapiens 41Trp Val Ser Gly Ile Ser Tyr Ser Ser Ser Ala
Thr Tyr Tyr Ala Asp 1 5 10 15 Ser Val Lys Gly 20 4220PRTHomo
sapiens 42Trp Val Ser Ala Ile Thr Tyr Trp Gly Ser Asn Thr Tyr Tyr
Ala Asp 1 5 10 15 Ser Val Lys Gly 20 4320PRTHomo sapiens 43Trp Met
Gly Arg Ile Ile Pro Asn Phe Gly Thr Ala Asn Tyr Ala Gln 1 5 10 15
Lys Phe Gln Gly 20 4420PRTHomo sapiens 44Trp Met Gly Ile Ile Asn
Pro Gln Asn Gly Gly Thr Asn Tyr Ala Gln 1 5 10 15 Lys Phe Gln Gly
20 4520PRTHomo sapiens 45Trp Met Gly Ile Ile Asp Pro Arg Glu Ser
Phe Thr Arg Tyr Ser Pro 1 5 10 15 Ser Phe Gln Gly 20 4621PRTHomo
sapiens 46Trp Leu Gly Arg Ile Gly Tyr Arg Ser Lys Trp Met Asn Asp
Tyr Ala 1 5 10 15 Val Ser Val Lys Ser 20 4720PRTHomo sapiens 47Trp
Met Gly Gly Ile Val Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln 1 5 10
15 Lys Phe Gln Gly 20 4820PRTHomo sapiens 48Trp Val Ser Gly Ile Ser
Gly Asn Gly Ser Asn Thr Tyr Tyr Ala Asp 1 5 10 15 Ser Val Lys Gly
20 4920PRTHomo sapiens 49Trp Met Gly Tyr Ile Ser Pro Tyr Ser Gly
Asp Thr Asn Tyr Ala Gln 1 5 10 15 Lys Phe Gln Gly 20 5021PRTHomo
sapiens 50Trp Leu Gly Arg Ile Ser Tyr Arg Ser Arg Trp Tyr Asn Asn
Tyr Ala 1 5 10 15 Val Ser Val Lys Ser 20 5120PRTHomo sapiens 51Trp
Met Gly Ile Ile His Pro Gly His Ser Tyr Thr Arg Tyr Ser Pro 1 5 10
15 Ser Phe Gln Gly 20 5222PRTHomo sapiens 52Trp Leu Gly Arg Ile Tyr
Tyr Arg Ser Lys Lys Trp Tyr Asn Asp Tyr 1 5 10 15 Ala Val Ser Val
Lys Ser 20 5321PRTHomo sapiens 53Trp Leu Gly Arg Ile Gln Tyr Arg
Ser Lys Trp Tyr Asn Ala Tyr Ala 1 5 10 15 Val Ser Val Lys Ser 20
5420PRTHomo sapiens 54Trp Met Gly Phe Ile Tyr Pro Asp Lys Ser Tyr
Thr Asn Tyr Ser Pro 1 5 10 15 Ser Phe Gln Gly 20 5521PRTHomo
sapiens 55Trp Leu Gly Arg Ile Tyr Tyr Arg Ser Gln Trp Tyr Asn Asp
Tyr Ala 1 5 10 15 Val Ser Val Lys Ser 20 5620PRTHomo sapiens 56Trp
Val Ser Phe Ile Ser Gly Tyr Gly Ser Ser Thr Tyr Tyr Ala Asp 1 5 10
15 Ser Val Lys Gly 20 5720PRTHomo sapiens 57Trp Val Ser Ser Ile Ser
Gly Gly Gly Ser Lys Thr Phe Tyr Ala Asp 1 5 10 15 Ser Val Lys Gly
20 5820PRTHomo sapiens 58Trp Met Gly Gly Ile Ile Pro Lys Phe Gly
Thr Ala Asn Tyr Ala Gln 1 5 10 15 Lys Phe Gln Gly 20 5920PRTHomo
sapiens 59Trp Met Gly Asn Ile Met Pro Ile Phe Gly Val Ala Asn Tyr
Ala Gln 1 5 10 15 Lys Phe Gln Gly 20 6021PRTHomo sapiens 60Trp Leu
Gly Arg Ile Arg Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 1 5 10 15
Val Ser Val Lys Ser 20 6119PRTHomo sapiens 61Trp Leu Ala Leu Ile
Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 1 5 10 15 Leu Lys Thr
6221PRTHomo sapiens 62Trp Leu Gly Arg Ile Gly Gln Arg Ser Lys Trp
Tyr Asn Asp Tyr Ala 1 5 10 15 Val Ser Val Lys Ser 20 6320PRTHomo
sapiens 63Trp Val Ser Thr Ile Ser Ser Asn Gly Ser Tyr Thr Tyr Tyr
Ala Asp 1 5 10 15 Ser Val Lys Gly 20 6420PRTHomo sapiens 64Trp Met
Gly Asn Ile Ile Pro Ala Phe Gly Tyr Ala Asn Tyr Ala Gln 1 5 10 15
Lys Phe Gln Gly 20 6520PRTHomo sapiens 65Trp Val Ser Asn Ile Ser
Gly Asn Gly Ser Ser Thr Tyr Tyr Ala Asp 1 5 10 15 Ser Val Lys Gly
20 6620PRTHomo sapiens 66Trp Val Ser Tyr Ile Arg Ser Gly Ser Ser
Asp Thr Tyr Tyr Ala Asp 1 5 10 15 Ser Val Lys Gly 20 6712PRTHomo
sapiens 67Tyr Gly His Gly Met Tyr Gly Gly Ala Leu Asp Val 1 5 10
6812PRTHomo sapiens 68Ile Asn Tyr Ile Tyr Lys Gly Val His Phe Asp
Tyr 1 5 10 6910PRTHomo sapiens 69Trp His His Gly Thr Trp Ile Phe
Asp Tyr 1 5 10 706PRTHomo sapiens 70Arg Thr Ser Met Asp Tyr 1 5
7111PRTHomo sapiens 71Gly Gln Leu Tyr Gly Gly Thr Tyr Met Asp Gly 1
5 10 728PRTHomo sapiens 72Pro Met Asp Asn Leu Pro Asp Ile 1 5
737PRTHomo sapiens 73Tyr Leu Tyr Tyr Phe Asp Val 1 5 746PRTHomo
sapiens 74Thr Lys Phe Phe Ala Asn 1 5 756PRTHomo sapiens 75Gly Ile
Tyr Phe Ala Phe 1 5 7611PRTHomo sapiens 76Lys His Lys Tyr Arg Ile
Gly Ser Met Asp Val 1 5 10 778PRTHomo sapiens 77Tyr Met Lys Gly Gly
Tyr Asp Tyr 1 5 788PRTHomo sapiens 78Met Gln Gly Phe Gln Leu Asp
Tyr 1 5 796PRTHomo sapiens 79Thr Tyr Thr Phe Ala Val 1 5 807PRTHomo
sapiens 80Lys Trp Leu Phe Tyr Asp Tyr 1 5 815PRTHomo sapiens 81Gly
Trp Gln Asp Phe 1 5 8214PRTHomo sapiens 82Tyr Tyr Ser Asp His Phe
Gly Leu Tyr Pro Tyr Phe Asp Tyr 1 5 10 8318PRTHomo sapiens 83Gly
Asp Gly Gly Pro Ser Ser Gln Gly Asn Tyr Phe Gly Trp Val Tyr 1 5 10
15 Asp Val 8412PRTHomo sapiens 84Asn Tyr Ser Gly Pro Met Tyr Tyr
Tyr Gly Asp Val 1 5 10 8511PRTHomo sapiens 85Gly Phe His Gly Ser
Thr Met Tyr Phe Asp Val 1 5 10 868PRTHomo sapiens 86Gly Leu Gly Gly
Ser Phe Asp Val 1 5 8711PRTHomo sapiens 87Gly Trp Ile Thr Gly Trp
Arg Ile Phe Asp Tyr 1 5 10 8811PRTHomo sapiens 88Lys Met Tyr Trp
Trp Ser Asp Gly Phe Asp Tyr 1 5 10 8912PRTHomo sapiens 89Tyr Pro
Gly Pro Thr Gly His Val Phe Phe Asp Ile 1 5 10 9012PRTHomo sapiens
90Tyr Pro Gly Pro Thr Gly His Val Phe Phe Asp Ile 1 5 10 916PRTHomo
sapiens 91Glu Met Arg Leu Ala Tyr 1 5 9214PRTHomo sapiens 92Gly Tyr
His Gln Gly Leu Tyr Gly Asn His Met Phe Asp Val 1 5 10 938PRTHomo
sapiens 93Ile Gln Gly Trp Asn Tyr Asp Val 1 5 948PRTHomo sapiens
94Ser Arg Phe Gly Tyr Phe Asp Val 1 5 9510PRTHomo sapiens 95Phe Val
Ala Arg Leu Asn Val Phe Asp Tyr 1 5 10 966PRTHomo sapiens 96Lys Phe
Thr Phe Asp Val 1 5 9710PRTHomo sapiens 97Leu Ile Ala Thr Leu Gly
Thr Phe Asp Tyr 1 5 10 9811PRTHomo sapiens 98Thr Ala Pro Ala Gly
His Gly Val Phe Ala Asn 1 5 10 9912PRTHomo sapiens 99Arg Ala Ser
Gln Ser Val Arg Ser Ser Arg Leu Ala 1 5 10 10011PRTHomo sapiens
100Arg Ala Ser Gln Ile Val Ser Gly Tyr Leu Ala 1 5 10 10113PRTHomo
sapiens 101Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Ser 1 5
10 10214PRTHomo sapiens 102Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
Asn Tyr Val Ser 1 5 10 10314PRTHomo sapiens 103Thr Gly Thr Ser Ser
Asp Ile Gly Gly Tyr Asn Ser Val Ser 1 5 10 10411PRTHomo sapiens
104Arg Ala Ser Gln Asn Ile Gly Ser Tyr Leu Asn 1 5 10 10514PRTHomo
sapiens 105Thr Gly Thr Ser Ser Asp Val Gly Ala Ser Asp Thr Val Thr
1 5 10 10616PRTHomo sapiens 106Arg Ser Ser Gln Ser Leu Leu His Ser
Asn Gly Tyr Thr Tyr Leu Ser 1 5 10 15 10713PRTHomo sapiens 107Ser
Gly Ser Ser Ser Asn Ile Gly Pro Asn Tyr Val Ser 1 5 10 10812PRTHomo
sapiens 108Arg Ala Ser Gln Ser Leu Thr Ser Asn Gln Leu Ala 1 5 10
10914PRTHomo sapiens 109Thr Gly Thr Ser Ser Asp Val Gly Gly Asn Asn
Phe Val Ser 1 5 10 11011PRTHomo sapiens 110Arg Ala Ser Gln Thr Ile
Ser Ser Ala Leu Ala 1 5 10 11114PRTHomo sapiens 111Thr Gly Thr Ser
Ser Asp Val Gly Asn Phe Asn Tyr Val Asn 1 5 10 11212PRTHomo sapiens
112Arg Ala Ser Gln Ser Val Thr Ser Asn Tyr Leu Ala 1 5 10
11311PRTHomo sapiens 113Arg Ala Ser Gln Ser Ile Asn Arg Ser Leu Thr
1 5 10 11414PRTHomo sapiens 114Thr Gly Thr Ser Ser Asp Ile Gly Gly
Phe Asn Tyr Val Ser 1 5 10 11511PRTHomo sapiens 115Ser Gly Asp Asn
Ile Pro Asn Phe Tyr Val His 1 5 10 11614PRTHomo sapiens 116Thr Gly
Thr Ser Ser Asp Ile Gly Arg Tyr His Tyr Val Ser 1 5 10 11713PRTHomo
sapiens 117Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ser Val Asn 1 5
10 11814PRTHomo sapiens 118Thr Gly Thr Ser Ser Asp Val Gly Asp Tyr
Asn Tyr Val Ser 1 5 10 11914PRTHomo sapiens 119Thr Gly Thr Ser Ser
Asp Val Gly Asp Tyr Asn Tyr Val Ser 1 5 10 12011PRTHomo sapiens
120Ser Gly Asp Asn Leu Arg Ser Lys Tyr Ala His 1 5 10 12111PRTHomo
sapiens 121Ser Gly Asp Asn Ile Gly Ser Lys Val Ala Thr 1 5 10
12214PRTHomo sapiens 122Thr Gly Thr Ser Ser Asp Ile Gly His Phe Asn
Tyr Val Ser 1 5 10 12313PRTHomo sapiens 123Ser Gly Ser Ser Ser Asn
Ile Gly Ser His Thr Val Asn 1 5 10 12413PRTHomo sapiens 124Ser Gly
Ser Ser Ser Asn Ile Gly Asn Asn Arg Val Ser 1 5 10 12514PRTHomo
sapiens 125Thr Gly Thr Ser Ser Asp Ile Gly Thr Tyr Asn His Val Ser
1 5 10 12614PRTHomo sapiens 126Thr Gly Ser Ser Ser Asn Ile Gly Ile
Gly Tyr Asp Val Asn 1 5 10 12714PRTHomo sapiens 127Thr Gly Thr Ser
Ser Asp Leu Gly Gly Tyr Ser Tyr Val Ser 1 5 10 12813PRTHomo sapiens
128Ser Gly Ser Ser Ser Asn Ile Gly Asn Tyr Arg Val Ser 1 5 10
12911PRTHomo sapiens 129Leu Leu Ile Tyr Gly Ala Ser Lys Arg Ala Thr
1 5 10 13011PRTHomo sapiens 130Leu Leu Ile Tyr Gly Ala Ser Ser Arg
Ala Thr 1 5 10 13111PRTHomo sapiens 131Leu Leu Ile Tyr Asn Asp Asn
Gln Arg Pro Ser 1 5 10 13211PRTHomo sapiens 132Leu Met Ile Tyr Ser
Val Ser Lys Arg Pro Ser 1 5 10 13311PRTHomo sapiens 133Leu Met Ile
Tyr Gly Val Asn Asn Arg Pro Ser 1 5 10 13411PRTHomo sapiens 134Leu
Leu Ile Tyr Asn Ser Ser Thr Leu Gln Ser 1 5 10 13511PRTHomo sapiens
135Leu Met Ile Tyr Ala Val Asn Lys Arg Pro Ser 1 5 10 13611PRTHomo
sapiens 136Leu Leu Ile Tyr Leu Gly Ser Lys Arg Ala Ser 1 5 10
13711PRTHomo sapiens 137Leu Leu Ile His Gly Asn Ala Asn Arg Pro Ser
1 5 10 13811PRTHomo sapiens 138Leu Leu Ile Tyr Asp Ser Ser Asn Arg
Ala Thr 1 5 10 13911PRTHomo sapiens 139Leu Met Ile Tyr Tyr Gly Asp
Ser Arg Pro Ser 1 5 10 14011PRTHomo sapiens 140Leu Leu Ile Tyr Gly
Ala Ser Thr Leu Gln Ser 1 5 10 14111PRTHomo sapiens 141Leu Met Ile
Tyr Ser Val Ser Ser Arg Pro Ser 1 5 10 14211PRTHomo sapiens 142Leu
Leu Ile Tyr Gly Ser Ser Ser Arg Ala Thr 1
5 10 14311PRTHomo sapiens 143Leu Leu Ile Tyr Ala Ala Ser Asn Leu
Gln Ser 1 5 10 14411PRTHomo sapiens 144Leu Met Ile Tyr Asp Val Ser
Asn Arg Pro Ser 1 5 10 14511PRTHomo sapiens 145Leu Val Ile Tyr Glu
Asp Ser Asp Arg Pro Ser 1 5 10 14611PRTHomo sapiens 146Val Met Ile
Tyr Ser Val Ser Lys Arg Pro Ser 1 5 10 14710PRTHomo sapiens 147Leu
Leu Ile Tyr Asn Asn Gln Arg Pro Ser 1 5 10 14811PRTHomo sapiens
148Leu Met Ile Tyr Arg Val Asp Asn Arg Pro Ser 1 5 10 14911PRTHomo
sapiens 149Leu Leu Ile Tyr Ser Asn Ser Gln Arg Pro Ser 1 5 10
15011PRTHomo sapiens 150Leu Val Ile Tyr Ser Lys Asp Asn Arg Pro Ser
1 5 10 15111PRTHomo sapiens 151Leu Val Ile Tyr Tyr Asp Asn Asp Arg
Pro Ser 1 5 10 15211PRTHomo sapiens 152Leu Met Ile Tyr Ser Val Asn
Asn Arg Pro Ser 1 5 10 15311PRTHomo sapiens 153Leu Met Ile Tyr Ser
Val Ile Ser Arg Pro Ser 1 5 10 15411PRTHomo sapiens 154Leu Leu Ile
Tyr Asp Val Asn Lys Arg Pro Ser 1 5 10 15511PRTHomo sapiens 155Leu
Leu Ile Tyr Gly Asn Asn Lys Arg Pro Ser 1 5 10 15611PRTHomo sapiens
156Leu Met Ile Tyr Asn Val Asn Lys Arg Pro Ser 1 5 10 15711PRTHomo
sapiens 157Leu Leu Ile Tyr Lys Asn Thr Asn Arg Pro Ser 1 5 10
15811PRTHomo sapiens 158Leu Met Ile Tyr Asn Val Asn Asn Arg Pro Ser
1 5 10 15911PRTHomo sapiens 159Val Met Ile Tyr Gly Val Thr Lys Arg
Pro Ser 1 5 10 1608PRTHomo sapiens 160Gln Gln Tyr Tyr Asp Phe Pro
Pro 1 5 1619PRTHomo sapiens 161Gln Gln Tyr Ser His Asp Pro Ser Gly
1 5 1628PRTHomo sapiens 162Gln Gln Phe Tyr Ser Lys Pro Ile 1 5
1639PRTHomo sapiens 163Gln Gln Tyr Ser Gln Asp Pro Ser Ser 1 5
1649PRTHomo sapiens 164Gln Gln Trp Ser Leu Arg Ser Pro Phe 1 5
1659PRTHomo sapiens 165Ser Thr Tyr Asp Arg Arg Thr Phe Ser 1 5
16610PRTHomo sapiens 166Ser Ser Trp Asp Arg Ala Asp Gly Ser Tyr 1 5
10 16710PRTHomo sapiens 167Gly Ala Trp Ala His Met Ser Leu Gly Lys
1 5 10 16810PRTHomo sapiens 168Ala Thr Trp Asp His Ser Gln Met Gly
Lys 1 5 10 16910PRTHomo sapiens 169Ser Ser Tyr Asp Ile Glu Ser Ala
Thr Pro 1 5 10 1708PRTHomo sapiens 170Gln Gln Tyr Tyr Asn Phe Ser
Phe 1 5 1718PRTHomo sapiens 171Gln Gln Arg Ser Asn Met Pro Ile 1 5
1728PRTHomo sapiens 172Ala Ser Arg Asp Ser Ser Ser Met 1 5
1738PRTHomo sapiens 173Gln Gln Tyr Tyr Asp Ser Ser Ser 1 5
17410PRTHomo sapiens 174Gln Ser Tyr Asp Phe Phe Thr Asn Ser Ser 1 5
10 1758PRTHomo sapiens 175Gln Gln Tyr Gly Ser Phe Pro Ala 1 5
17610PRTHomo sapiens 176Gln Ser Trp Asp Ala Pro Met Gly Met Trp 1 5
10 1778PRTHomo sapiens 177Gln Gln Tyr Tyr Ser Tyr Ser Val 1 5
1789PRTHomo sapiens 178Gly Ala Tyr Thr Thr Asp Thr Leu Ser 1 5
1798PRTHomo sapiens 179Gln Gln Tyr Ser Asp Ile Pro Ala 1 5
1808PRTHomo sapiens 180Leu Gln Val Tyr Asn Leu Pro Leu 1 5
18110PRTHomo sapiens 181Ser Thr Tyr Asp Asp Asp Gln Gln Asp Ala 1 5
10 18210PRTHomo sapiens 182Gln Ser Tyr Asp Lys Pro Thr Phe Ser Gly
1 5 10 18310PRTHomo sapiens 183Ser Ala Tyr Asp Thr Asn Asn Tyr Leu
Ser 1 5 10 1847PRTHomo sapiens 184Gln Ala Tyr Ala Ser Asn Ile 1 5
1858PRTHomo sapiens 185Gln Ser Trp Val Gly Pro Ser Thr 1 5
1869PRTHomo sapiens 186Gln Ser Tyr Asp His Asn Ser Tyr Thr 1 5
1878PRTHomo sapiens 187Ser Ser Trp Ala His Asp His Lys 1 5
18810PRTHomo sapiens 188Gln Ser Tyr Asp Gly Gln Met Ser Thr Ser 1 5
10 18910PRTHomo sapiens 189Ser Thr Tyr Asp His Thr Ser Ser Gly Phe
1 5 10 1908PRTHomo sapiens 190Ala Ser Phe Thr Phe Pro Ser Leu 1 5
19110PRTHomo sapiens 191Ala Ser Trp Asp Ser Val Gln Val Ser Pro 1 5
10 1929PRTHomo sapiens 192Ser Ala Trp Asp Leu Leu Glu Val Tyr 1 5
1938PRTHomo sapiens 193Ser Ala Tyr Ala Pro Ser Ala Val 1 5
19410PRTHomo sapiens 194Ser Ser Tyr Asp Ser Phe His His Gly Ile 1 5
10 19510PRTHomo sapiens 195Ser Ser Tyr Asp Tyr Val Ser Ser Asp Thr
1 5 10 19610PRTHomo sapiens 196Gln Thr Tyr Asp Glu His Gly Phe His
Ile 1 5 10 19710PRTHomo sapiens 197Ser Thr Tyr Thr Gly Leu Pro Phe
Thr Thr 1 5 10 198121PRTHomo sapiens 198Gln Val Glu Leu Val Gln Ser
Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser
Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 20 25 30 Trp Ile Gly
Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly
Val Ile Met Pro Ser Asp Ser Tyr Thr Arg Tyr Ser Pro Ser Phe 50 55
60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr
Tyr Cys 85 90 95 Ala Arg Tyr Gly His Gly Met Tyr Gly Gly Ala Leu
Asp Val Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115
120 199121PRTHomo sapiens 199Gln Val Gln Leu Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys
Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 20 25 30 Trp Ile Gly Trp Val
Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Phe Ile
Trp Pro Val Asp Ser Trp Thr Gln Tyr Ser Pro Ser Phe 50 55 60 Gln
Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70
75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr
Cys 85 90 95 Ala Arg Tyr Gly His Gly Met Tyr Gly Gly Ala Leu Asp
Val Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120
200121PRTHomo sapiens 200Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly
Ser Gly Tyr Ser Phe Thr Asn Tyr 20 25 30 Trp Ile Gly Trp Val Arg
Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Phe Ile Trp
Pro Val Asp Ser Trp Thr Gln Tyr Ser Pro Ser Phe 50 55 60 Gln Gly
Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85
90 95 Ala Arg Tyr Gly His Gly Met Tyr Gly Gly Ala Leu Asp Val Trp
Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120
201121PRTHomo sapiens 201Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly
Ser Gly Tyr Ser Phe Thr Asn Tyr 20 25 30 Trp Ile Gly Trp Val Arg
Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Trp
Pro Ile Asp Ser Phe Thr Gln Tyr Ser Pro Ser Phe 50 55 60 Gln Gly
Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85
90 95 Ala Arg Tyr Gly His Gly Met Tyr Gly Gly Ala Leu Asp Val Trp
Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120
202121PRTHomo sapiens 202Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly
Ser Gly Tyr Ser Phe Thr Asn Tyr 20 25 30 Trp Ile Gly Trp Val Arg
Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Val Ile Met
Pro Ser Asp Ser Tyr Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly
Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85
90 95 Ala Arg Tyr Gly His Gly Met Tyr Gly Gly Ala Leu Asp Val Trp
Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120
203121PRTHomo sapiens 203Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly
Ser Gly Tyr Ser Phe Thr Asn Tyr 20 25 30 Trp Ile Gly Trp Val Arg
Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Val Ile Met
Pro Ser Asp Ser Tyr Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly
Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85
90 95 Ala Arg Tyr Gly His Gly Met Tyr Gly Gly Ala Leu Asp Val Trp
Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120
204121PRTHomo sapiens 204Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly
Ser Gly Tyr Ser Phe Thr Asn Tyr 20 25 30 Trp Ile Gly Trp Val Arg
Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Val Ile Met
Pro Ser Asp Ser Tyr Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly
Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85
90 95 Ala Arg Tyr Gly His Gly Met Tyr Gly Gly Ala Leu Asp Val Trp
Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120
205121PRTHomo sapiens 205Gln Val Gln Leu Val Glu Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Ala Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Met
Tyr Asp Ser Ser Ser Thr Phe Tyr Ala Asp Ser Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Ile Asn Tyr Ile Tyr Lys Gly Val His Phe Asp Tyr Trp
Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120
206119PRTHomo sapiens 206Gln Val Glu Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Gly Asn 20 25 30 Tyr Ile Asn Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn
Pro His Gly Gly Asp Thr Lys Tyr Ala Gln Lys Phe 50 55 60 Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Trp His His Gly Thr Trp Ile Phe Asp Tyr Trp Gly Gln
Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 207119PRTHomo
sapiens 207Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro
Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
Phe Thr Gly Asn 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly
Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Thr Lys Gly
Trp Thr Leu Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met
Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser
Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg
Trp His His Gly Thr Trp Ile Phe Asp Tyr Trp Gly Gln Gly 100 105 110
Thr Leu Val Thr Val Ser Ser 115 208121PRTHomo sapiens 208Gln Val
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 20
25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp
Met 35 40 45 Gly Phe Ile Trp Pro Ser Asp Ser Trp Thr Ser Tyr Ser
Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser
Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser
Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Tyr Gly His Gly Met
Tyr Gly Gly Ala Leu Asp Val Trp Gly 100 105 110 Gln Gly Thr Leu Val
Thr Val Ser Ser 115 120 209119PRTHomo sapiens 209Gln Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val
Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Asn 20 25 30
Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35
40 45 Gly Ile Ile Asn Pro His Gly Gly Asp Thr Lys Tyr Ala Gln Lys
Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser
Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Trp His His Gly Thr Trp Ile
Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser
115 210115PRTHomo sapiens 210Gln Val Gln Leu Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys
Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Tyr Phe Ser Trp Val
Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile
Ile Pro Lys Phe Gly Ser Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln
Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70
75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr
Cys 85 90 95 Ala Arg Arg Thr Ser Met Asp Tyr Trp Gly Gln Gly Thr
Leu Val Thr 100 105
110 Val Ser Ser 115 211115PRTHomo sapiens 211Gln Val Gln Leu Val
Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys
Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Tyr
Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40
45 Gly Gly Ile Ile Pro Lys Phe Gly Ser Ala Asn Tyr Ala Gln Lys Phe
50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr
Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
Val Tyr Tyr Cys 85 90 95 Ala Arg Arg Thr Ser Met Asp Tyr Trp Gly
Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 212120PRTHomo
sapiens 212Gln Val Glu Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro
Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser
Phe Thr Ser Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asp Pro Gly Asp Ser
Arg Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile
Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser
Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg
Gly Gln Leu Tyr Gly Gly Thr Tyr Met Asp Gly Trp Gly Gln 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 213121PRTHomo sapiens
213Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Asp Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 Ser Ala Ile Met Tyr Asp Ser Ser Ser Thr
Phe Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ile Asn
Tyr Ile Tyr Lys Gly Val His Phe Asp Tyr Trp Gly 100 105 110 Gln Gly
Thr Leu Val Thr Val Ser Ser 115 120 214116PRTHomo sapiens 214Gln
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Gly Glu 1 5 10
15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr
20 25 30 Tyr Trp Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu
Trp Ile 35 40 45 Gly Glu Ile Tyr His Ser Gly Gly Thr Tyr Tyr Asn
Pro Ser Leu Lys 50 55 60 Gly Arg Val Thr Ile Ser Val Asp Thr Ser
Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Glu
Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Pro Met Asp Asn Leu
Pro Asp Ile Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser
115 215116PRTHomo sapiens 215Gln Val Gln Leu Val Glu Ser Gly Gly
Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met Ser Trp Val
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile
Ser Tyr Ser Ser Ser Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70
75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
Cys 85 90 95 Ala Arg Tyr Leu Tyr Tyr Phe Asp Val Trp Gly Gln Gly
Thr Leu Val 100 105 110 Thr Val Ser Ser 115 216115PRTHomo sapiens
216Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Asn Ser 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 Ser Ala Ile Thr Tyr Trp Gly Ser Asn Thr
Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Thr Lys
Phe Phe Ala Asn Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser
Ser 115 217115PRTHomo sapiens 217Gln Val Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 20 25 30 Ser Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg
Ile Ile Pro Asn Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65
70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Gly Ile Tyr Phe Ala Phe Trp Gly Gln Gly
Thr Leu Val Thr 100 105 110 Val Ser Ser 115 218120PRTHomo sapiens
218Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
Ser Tyr 20 25 30 Ala Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly
Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Gln Asn Gly Gly Thr
Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg
Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu
Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Lys His
Lys Tyr Arg Ile Gly Ser Met Asp Val Trp Gly Gln 100 105 110 Gly Thr
Leu Val Thr Val Ser Ser 115 120 219117PRTHomo sapiens 219Gln Val
Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 20
25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp
Met 35 40 45 Gly Ile Ile Asp Pro Arg Glu Ser Phe Thr Arg Tyr Ser
Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser
Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser
Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Tyr Met Lys Gly Gly
Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser
115 220120PRTHomo sapiens 220Gln Val Gln Leu Gln Gln Ser Gly Pro
Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala
Ile Ser Gly Asp Ser Val Ser Ser Arg 20 25 30 Ser Ala Ala Trp Gly
Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu 35 40 45 Trp Leu Gly
Arg Ile Gly Tyr Arg Ser Lys Trp Met Asn Asp Tyr Ala 50 55 60 Val
Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 65 70
75 80 Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala
Val 85 90 95 Tyr Tyr Cys Ala Arg Met Gln Gly Phe Gln Leu Asp Tyr
Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120
221115PRTHomo sapiens 221Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Gly Thr Phe Ser Asn Tyr 20 25 30 Ser Leu His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Val
Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly
Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Thr Tyr Thr Phe Ala Val Trp Gly Gln Gly Thr Leu Val
Thr 100 105 110 Val Ser Ser 115 222116PRTHomo sapiens 222Gln Val
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20
25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val 35 40 45 Ser Gly Ile Ser Gly Asn Gly Ser Asn Thr Tyr Tyr Ala
Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Lys Trp Leu Phe Tyr
Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115
223114PRTHomo sapiens 223Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ile Tyr 20 25 30 Asp Met His Trp Val Arg
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Ser
Pro Tyr Ser Gly Asp Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Gly Trp Gln Asp Phe Trp Gly Gln Gly Thr Leu Val Thr
Val 100 105 110 Ser Ser 224126PRTHomo sapiens 224Gln Val Gln Leu
Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu
Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 20 25 30
Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu 35
40 45 Trp Leu Gly Arg Ile Ser Tyr Arg Ser Arg Trp Tyr Asn Asn Tyr
Ala 50 55 60 Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr
Ser Lys Asn 65 70 75 80 Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro
Glu Asp Thr Ala Val 85 90 95 Tyr Tyr Cys Ala Arg Tyr Tyr Ser Asp
His Phe Gly Leu Tyr Pro Tyr 100 105 110 Phe Asp Tyr Trp Gly Gln Gly
Thr Leu Val Thr Val Ser Ser 115 120 125 225126PRTHomo sapiens
225Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Asn
Thr Ser 20 25 30 Trp Ile Trp Val Arg Gln Met Pro Gly Lys Gly Leu
Glu Trp Met Gly 35 40 45 Ile Ile His Pro Gly His Ser Tyr Thr Arg
Tyr Ser Pro Ser Phe Gln 50 55 60 Gly Gln Val Thr Ile Ser Ala Asp
Lys Ser Ile Ser Thr Ala Tyr Leu 65 70 75 80 Gln Trp Ser Ser Leu Lys
Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 85 90 95 Arg Gly Asp Gly
Gly Pro Ser Ser Gln Gly Asn Tyr Phe Gly Trp Val 100 105 110 Tyr Asp
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125
226125PRTHomo sapiens 226Gln Val Gln Leu Gln Gln Ser Gly Pro Gly
Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Ile
Ser Gly Asp Ser Val Ser Ser Asn 20 25 30 Ser Ala Ala Trp Ser Trp
Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu 35 40 45 Trp Leu Gly Arg
Ile Tyr Tyr Arg Ser Lys Lys Trp Tyr Asn Asp Tyr 50 55 60 Ala Val
Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys 65 70 75 80
Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala 85
90 95 Val Tyr Tyr Cys Ala Arg Asn Tyr Ser Gly Pro Met Tyr Tyr Tyr
Gly 100 105 110 Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125 227123PRTHomo sapiens 227Gln Val Gln Leu Gln Gln Ser
Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr
Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 20 25 30 Ser Ala Ala
Trp Ser Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu 35 40 45 Trp
Leu Gly Arg Ile Gln Tyr Arg Ser Lys Trp Tyr Asn Ala Tyr Ala 50 55
60 Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn
65 70 75 80 Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr
Ala Val 85 90 95 Tyr Tyr Cys Ala Arg Gly Phe His Gly Ser Thr Met
Tyr Phe Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ser 115 120 228117PRTHomo sapiens 228Gln Val Gln Leu Val Gln Ser
Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser
Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 20 25 30 Trp Ile Gly
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly
Phe Ile Tyr Pro Asp Lys Ser Tyr Thr Asn Tyr Ser Pro Ser Phe 50 55
60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr
Tyr Cys 85 90 95 Ala Arg Gly Leu Gly Gly Ser Phe Asp Val Trp Gly
Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 229123PRTHomo
sapiens 229Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro
Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser
Val Ser Ser Asn 20 25 30 Ser Ala Ser Trp Ser Trp Ile Arg Gln Ser
Pro Gly Arg Gly Leu Glu 35 40 45 Trp Leu Gly Arg Ile Tyr Tyr Arg
Ser Gln Trp Tyr Asn Asp Tyr Ala 50 55 60 Val Ser Val Lys Ser Arg
Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 65 70 75 80 Gln Phe Ser Leu
Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 85 90 95 Tyr Tyr
Cys
Ala Arg Gly Trp Ile Thr Gly Trp Arg Ile Phe Asp Tyr 100 105 110 Trp
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 230120PRTHomo
sapiens 230Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro
Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr
Phe Ser Thr Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly
Lys Gly Leu Glu Trp Val 35 40 45 Ser Phe Ile Ser Gly Tyr Gly Ser
Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg
Lys Met Tyr Trp Trp Ser Asp Gly Phe Asp Tyr Trp Gly Gln 100 105 110
Gly Thr Leu Val Thr Val Ser Ser 115 120 231121PRTHomo sapiens
231Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Arg Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Gly Gly Ser Lys Thr
Phe Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Tyr Pro
Gly Pro Thr Gly His Val Phe Phe Asp Ile Trp Gly 100 105 110 Gln Gly
Thr Leu Val Thr Val Ser Ser 115 120 232116PRTHomo sapiens 232Gln
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10
15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30 Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
Trp Met 35 40 45 Gly Gly Ile Ile Pro Lys Phe Gly Thr Ala Asn Tyr
Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu
Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser
Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Thr Ile Gly Ile
Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser
115 233115PRTHomo sapiens 233Gln Val Gln Leu Val Gln Ser Gly Ala
Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys
Ala Ser Gly Gly Thr Phe Ser Ser His 20 25 30 Ala Ile Ser Trp Val
Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Asn Ile
Met Pro Ile Phe Gly Val Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln
Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70
75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr
Cys 85 90 95 Ala Arg Glu Met Arg Leu Ala Tyr Trp Gly Gln Gly Thr
Leu Val Thr 100 105 110 Val Ser Ser 115 234126PRTHomo sapiens
234Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser
Ser Asn 20 25 30 Thr Ala Ala Trp Ser Trp Ile Arg Gln Ser Pro Gly
Arg Gly Leu Glu 35 40 45 Trp Leu Gly Arg Ile Arg Tyr Arg Ser Lys
Trp Tyr Asn Asp Tyr Ala 50 55 60 Val Ser Val Lys Ser Arg Ile Thr
Ile Asn Pro Asp Thr Ser Lys Asn 65 70 75 80 Gln Phe Ser Leu Gln Leu
Asn Ser Val Thr Pro Glu Asp Thr Ala Val 85 90 95 Tyr Tyr Cys Ala
Arg Gly Tyr His Gln Gly Leu Tyr Gly Asn His Met 100 105 110 Phe Asp
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125
235118PRTHomo sapiens 235Gln Val Gln Leu Lys Glu Ser Gly Pro Ala
Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe
Ser Gly Phe Ser Leu Ser Ser Ser 20 25 30 Gly Val Gly Val Ser Trp
Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu
Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 50 55 60 Leu Lys
Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85
90 95 Cys Ala Arg Ile Gln Gly Trp Asn Tyr Asp Val Trp Gly Gln Gly
Thr 100 105 110 Leu Val Thr Val Ser Ser 115 236120PRTHomo sapiens
236Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser
Ser Ser 20 25 30 Ser Ala Ala Trp Ser Trp Ile Arg Gln Ser Pro Gly
Arg Gly Leu Glu 35 40 45 Trp Leu Gly Arg Ile Gly Gln Arg Ser Lys
Trp Tyr Asn Asp Tyr Ala 50 55 60 Val Ser Val Lys Ser Arg Ile Thr
Ile Asn Pro Asp Thr Ser Lys Asn 65 70 75 80 Gln Phe Ser Leu Gln Leu
Asn Ser Val Thr Pro Glu Asp Thr Ala Val 85 90 95 Tyr Tyr Cys Ala
Arg Ser Arg Phe Gly Tyr Phe Asp Val Trp Gly Gln 100 105 110 Gly Thr
Leu Val Thr Val Ser Ser 115 120 237118PRTHomo sapiens 237Gln Val
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 20
25 30 Tyr Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
Ser 35 40 45 Thr Ile Ser Ser Asn Gly Ser Tyr Thr Tyr Tyr Ala Asp
Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Phe Val Ala Arg Leu Asn
Val Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser
Ser 115 238115PRTHomo sapiens 238Gln Val Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys
Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 20 25 30 Thr Ile Ser Trp
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Asn
Ile Ile Pro Ala Phe Gly Tyr Ala Asn Tyr Ala Gln Lys Phe 50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65
70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Lys Phe Thr Phe Asp Val Trp Gly Gln Gly
Thr Leu Val Thr 100 105 110 Val Ser Ser 115 239118PRTHomo sapiens
239Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Ser Tyr 20 25 30 Tyr Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val Ser 35 40 45 Asn Ile Ser Gly Asn Gly Ser Ser Thr Tyr
Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Leu Ile Ala
Thr Leu Gly Thr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val
Thr Val Ser Ser 115 240120PRTHomo sapiens 240Gln Val Gln Leu Val
Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly
Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40
45 Ser Tyr Ile Arg Ser Gly Ser Ser Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys 85 90 95 Ala Arg Thr Ala Pro Ala Gly His Gly Val
Phe Ala Asn Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser
115 120 241110PRTHomo sapiens 241Asp Ile Val Leu Thr Gln Ser Pro
Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser
Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 20 25 30 Arg Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr
Gly Ala Ser Lys Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65
70 75 80 Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp
Phe Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
Arg Thr 100 105 110 242111PRTHomo sapiens 242Asp Ile Val Leu Thr
Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala
Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 20 25 30 Arg
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40
45 Ile Tyr Gly Ala Ser Lys Arg Ala Thr Gly Val Pro Ala Arg Phe Ser
50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr
Ser His Asp Pro 85 90 95 Ser Gly Thr Phe Gly Gln Gly Thr Lys Val
Glu Ile Lys Arg Thr 100 105 110 243110PRTHomo sapiens 243Asp Ile
Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 20
25 30 Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu
Leu 35 40 45 Ile Tyr Gly Ala Ser Lys Arg Ala Thr Gly Val Pro Ala
Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
Gln Gln Tyr Tyr Asp Phe Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Arg Thr 100 105 110 244110PRTHomo sapiens
244Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg
Ser Ser 20 25 30 Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala
Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Lys Arg Ala Thr Gly
Val Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe
Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Thr
Tyr Tyr Cys Gln Gln Tyr Tyr Asp Phe Pro 85 90 95 Pro Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 245110PRTHomo
sapiens 245Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser
Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser
Val Arg Ser Ser 20 25 30 Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly
Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Lys Arg Ala
Thr Gly Val Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe
Ala Val Tyr Tyr Cys Gln Gln Phe Tyr Ser Lys Pro 85 90 95 Ile Thr
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110
246111PRTHomo sapiens 246Asp Ile Val Leu Thr Gln Ser Pro Ala Thr
Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg
Ala Ser Gln Ser Val Arg Ser Ser 20 25 30 Arg Leu Ala Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala
Ser Lys Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 50 55 60 Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser His Asp Pro 85
90 95 Ser Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr
100 105 110 247111PRTHomo sapiens 247Asp Ile Val Leu Thr Gln Ser
Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu
Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 20 25 30 Arg Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile
Tyr Gly Ala Ser Lys Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 50 55
60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu
65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Gln
Asp Pro 85 90 95 Ser Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
Lys Arg Thr 100 105 110 248110PRTHomo sapiens 248Asp Ile Val Leu
Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg
Ala Thr Leu Ser Cys Arg Ala Ser Gln Ile Val Ser Gly Tyr 20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35
40 45 Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Ala Arg Phe Ser
Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp
Ser Leu Arg Ser Pro 85 90 95 Phe Thr Phe Gly Gln Gly Thr Lys Val
Glu Ile Lys Arg Thr 100 105 110 249111PRTHomo sapiens 249Asp Ile
Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15
Arg Val Thr Ile
Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val
Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45
Ile Tyr Asn Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50
55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Tyr Asp
Arg Arg Thr 85 90 95 Phe Ser Val Phe Gly Gly Gly Thr Lys Leu Thr
Val Leu Gly Gln 100 105 110 250111PRTHomo sapiens 250Asp Ile Val
Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg
Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25
30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45 Ile Tyr Asn Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg
Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile
Thr Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser
Thr Tyr Asp Arg Arg Thr 85 90 95 Phe Ser Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly Gln 100 105 110 251110PRTHomo sapiens
251Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg
Ser Ser 20 25 30 Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala
Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Lys Arg Ala Thr Gly
Val Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe
Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Thr
Tyr Tyr Cys Gln Gln Tyr Tyr Asp Phe Pro 85 90 95 Pro Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 252112PRTHomo
sapiens 252Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro
Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn
Ile Gly Ser Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly
Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asn Asp Asn Gln Arg Pro
Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr
Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu
Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Arg Ala Asp 85 90 95 Gly Ser
Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 100 105 110
253113PRTHomo sapiens 253Asp Ile Ala Leu Thr Gln Pro Ala Ser Val
Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly
Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr
Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Ser
Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly
Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Ala His Met 85
90 95 Ser Leu Gly Lys Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
Gly 100 105 110 Gln 254113PRTHomo sapiens 254Asp Ile Ala Leu Thr
Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr
Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn
Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40
45 Met Ile Tyr Ser Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser
Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr
Trp Asp His Ser 85 90 95 Gln Met Gly Lys Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly 100 105 110 Gln 255224PRTHomo sapiens
255Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly
Gly Tyr 20 25 30 Asn Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys
Ala Pro Lys Leu 35 40 45 Met Ile Tyr Gly Val Asn Asn Arg Pro Ser
Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr
Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala
Asp Tyr Tyr Cys Ser Ser Tyr Asp Ile Glu 85 90 95 Ser Ala Thr Pro
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 Gln Asp
Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly 115 120 125
Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser 130
135 140 Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys
Leu 145 150 155 160 Leu Ile Tyr Asn Asp Asn Gln Arg Pro Ser Gly Val
Pro Asp Arg Phe 165 170 175 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser
Leu Ala Ile Thr Gly Leu 180 185 190 Gln Ser Glu Asp Glu Ala Asp Tyr
Tyr Cys Ser Thr Tyr Asp Arg Arg 195 200 205 Thr Phe Ser Val Phe Gly
Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 210 215 220 256109PRTHomo
sapiens 256Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser
Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ile
Val Ser Gly Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Arg Ala Thr
Gly Val Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala
Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Phe Ser Phe 85 90 95 Thr Phe
Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 257109PRTHomo
sapiens 257Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn
Ile Gly Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Ser Ser Thr Leu Gln Ser
Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp
Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala
Thr Tyr Tyr Cys Gln Gln Arg Ser Asn Met Pro Ile 85 90 95 Thr Phe
Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 258111PRTHomo
sapiens 258Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ala Pro
Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp
Val Gly Ala Ser 20 25 30 Asp Thr Val Thr Trp Tyr Gln Gln His Pro
Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Ala Val Asn Lys Arg
Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly
Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp
Glu Ala Asp Tyr Tyr Cys Ala Ser Arg Asp Ser Ser 85 90 95 Ser Met
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 100 105 110
259114PRTHomo sapiens 259Asp Ile Val Met Thr Gln Ser Pro Leu Ser
Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg
Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Tyr Thr Tyr Leu
Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu
Ile Tyr Leu Gly Ser Lys Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Tyr 85
90 95 Tyr Asp Ser Ser Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
Lys 100 105 110 Arg Thr 260112PRTHomo sapiens 260Asp Ile Val Leu
Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val
Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Pro Asn 20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35
40 45 Ile His Gly Asn Ala Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr
Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser
Tyr Asp Phe Phe Thr 85 90 95 Asn Ser Ser Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly Gln 100 105 110 261110PRTHomo sapiens
261Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Thr
Ser Asn 20 25 30 Gln Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala
Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ser Ser Asn Arg Ala Thr Gly
Val Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe
Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val
Tyr Tyr Cys Gln Gln Tyr Gly Ser Phe Pro 85 90 95 Ala Thr Phe Gly
Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 262113PRTHomo
sapiens 262Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro
Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp
Val Gly Gly Asn 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro
Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Tyr Gly Asp Ser Arg
Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly
Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp
Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Ala Pro 85 90 95 Met Gly
Met Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110
Gln 263109PRTHomo sapiens 263Asp Ile Gln Met Thr Gln Ser Pro Ser
Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys
Arg Ala Ser Gln Thr Ile Ser Ser Ala 20 25 30 Leu Ala Trp Tyr Gln
Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala
Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70
75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Ser
Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr
100 105 264112PRTHomo sapiens 264Asp Ile Ala Leu Thr Gln Pro Ala
Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys
Thr Gly Thr Ser Ser Asp Val Gly Asn Phe 20 25 30 Asn Tyr Val Asn
Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile
Tyr Ser Val Ser Ser Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65
70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Tyr Thr
Thr Asp 85 90 95 Thr Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr
Val Leu Gly Gln 100 105 110 265110PRTHomo sapiens 265Asp Ile Val
Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu
Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Asn 20 25
30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45 Ile Tyr Gly Ser Ser Ser Arg Ala Thr Gly Val Pro Ala Arg
Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln
Gln Tyr Ser Asp Ile Pro 85 90 95 Ala Thr Phe Gly Gln Gly Thr Lys
Val Glu Ile Lys Arg Thr 100 105 110 266109PRTHomo sapiens 266Asp
Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10
15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Arg Ser
20 25 30 Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser
Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys
Leu Gln Val Tyr Asn Leu Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Arg Thr 100 105 267109PRTHomo sapiens 267Asp
Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10
15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Arg Ser
20 25 30 Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser
Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys
Leu Gln Val Tyr Asn Leu Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr
Lys Val Glu Ile Lys Arg Thr 100 105 268110PRTHomo sapiens 268Asp
Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 1 5 10
15 Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Pro Asn Phe Tyr Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35
40 45 Glu Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly
Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr
Gln Ala Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp
Lys Pro Thr Phe Ser 85 90 95 Gly Val Phe Gly Gly Gly Thr Lys Leu
Thr Val Leu Gly Gln 100 105 110 269113PRTHomo sapiens 269Asp Ile
Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Arg Tyr 20
25 30 His Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys
Val 35 40 45 Met Ile Tyr Ser Val Ser Lys Arg Pro Ser Gly Val Ser
Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu
Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr
Cys Ser Ala Tyr Asp Thr Asn 85 90 95 Asn Tyr Leu Ser Val Phe Gly
Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 Gln 270108PRTHomo
sapiens 270Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro
Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn
Ile Gly Asn Asn 20 25 30 Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly
Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asn Asn Gln Arg Pro Ser
Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Lys Ser Gly Thr Ser
Ala Ser Leu Ala Ile Thr Gly Leu Gln Ser 65 70 75 80 Glu Asp Glu Ala
Asp Tyr Tyr Cys Gln Ala Tyr Ala Ser Asn Ile Val 85 90 95 Phe Gly
Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 100 105 271111PRTHomo
sapiens 271Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro
Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp
Val Gly Asp Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro
Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Arg Val Asp Asn Arg
Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly
Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp
Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Val Gly Pro 85 90 95 Ser Thr
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 100 105 110
272111PRTHomo sapiens 272Asp Ile Val Leu Thr Gln Pro Pro Ser Val
Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly
Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln
Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn
Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser
Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp His Asn Ser 85
90 95 Tyr Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln
100 105 110 273108PRTHomo sapiens 273Asp Ile Glu Leu Thr Gln Pro
Pro Ser Val Ser Val Ala Pro Gly Gln 1 5 10 15 Thr Ala Arg Ile Ser
Cys Ser Gly Asp Asn Leu Arg Ser Lys Tyr Ala 20 25 30 His Trp Tyr
Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Ser
Lys Asp Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55
60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu
65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Ala His Asp His
Lys Val 85 90 95 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln
100 105 274110PRTHomo sapiens 274Asp Ile Glu Leu Thr Gln Pro Pro
Ser Val Ser Val Ala Pro Gly Gln 1 5 10 15 Thr Ala Arg Ile Ser Cys
Ser Gly Asp Asn Ile Gly Ser Lys Val Ala 20 25 30 Thr Trp Tyr Gln
Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp
Asn Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 65
70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Met
Ser Thr 85 90 95 Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
Gly Gln 100 105 110 275113PRTHomo sapiens 275Asp Ile Ala Leu Thr
Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr
Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn
Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40
45 Met Ile Tyr Ser Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser
Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr
Tyr Asp His Thr 85 90 95 Ser Ser Gly Phe Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly 100 105 110 Gln 276111PRTHomo sapiens
276Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly
His Phe 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys
Ala Pro Lys Leu 35 40 45 Met Ile Tyr Ser Val Ile Ser Arg Pro Ser
Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr
Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala
Asp Tyr Tyr Cys Ala Ser Phe Thr Phe Pro 85 90 95 Ser Leu Val Phe
Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 100 105 110
277112PRTHomo sapiens 277Asp Ile Val Leu Thr Gln Pro Pro Ser Val
Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly
Ser Ser Ser Asn Ile Gly Ser His 20 25 30 Thr Val Asn Trp Tyr Gln
Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Val
Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser
Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 65 70 75 80
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Ser Val Gln 85
90 95 Val Ser Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
Gln 100 105 110 278111PRTHomo sapiens 278Asp Ile Val Leu Thr Gln
Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile
Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Arg Val
Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45
Ile Tyr Gly Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50
55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp
Leu Leu Glu 85 90 95 Val Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr
Val Leu Gly Gln 100 105 110 279111PRTHomo sapiens 279Asp Ile Ala
Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser
Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Thr Tyr 20 25
30 Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45 Met Ile Tyr Asn Val Asn Lys Arg Pro Ser Gly Val Ser Asn
Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr
Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys
Ser Ala Tyr Ala Pro Ser 85 90 95 Ala Val Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly Gln 100 105 110 280113PRTHomo sapiens
280Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly
Ile Gly 20 25 30 Tyr Asp Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr
Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Lys Asn Thr Asn Arg Pro Ser
Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser
Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ser Glu Asp Glu Ala
Asp Tyr Tyr Cys Ser Ser Tyr Asp Ser Phe 85 90 95 His His Gly Ile
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 Gln
281113PRTHomo sapiens 281Asp Ile Ala Leu Thr Gln Pro Ala Ser Val
Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly
Thr Ser Ser Asp Leu Gly Gly Tyr 20 25 30 Ser Tyr Val Ser Trp Tyr
Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asn
Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly
Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp Tyr Val 85
90 95 Ser Ser Asp Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
Gly 100 105 110 Gln 282113PRTHomo sapiens 282Asp Ile Ala Leu Thr
Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr
Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn
Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Val 35 40
45 Met Ile Tyr Gly Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser
Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr
Tyr Asp Glu His 85 90 95 Gly Phe His Ile Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly 100 105 110 Gln 283112PRTHomo sapiens
283Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly
Asn Tyr 20 25 30 Arg Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala
Pro Lys Leu Leu 35 40 45 Ile Tyr Gly Asn Asn Lys Arg Pro Ser Gly
Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala
Ser Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp
Tyr Tyr Cys Ser Thr Tyr Thr Gly Leu Pro 85 90 95 Phe Thr Thr Val
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 100 105 110
284363DNAHomo sapiens 284caggtggaat tggttcagag cggcgcggaa
gtgaaaaaac cgggcgaaag cctgaaaatt 60agctgcaaag gttccggata ttcctttact
aattattgga ttggttgggt gcgccagatg 120cctgggaagg gtctcgagtg
gatgggcgtt atcatgccgt ctgatagcta tacccgttat 180tctccgagct
ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat
240cttcaatgga gcagcctgaa agcgagcgat acggccatgt attattgcgc
gcgttatggt 300catggtatgt atggtggtgc tcttgatgtt tggggccaag
gcaccctggt gacggttagc 360tca 363285363DNAHomo sapiens 285caggtgcaat
tggttcagag cggcgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt 60agctgcaaag
gttccggata ttcctttact aattattgga ttggttgggt gcgccagatg
120cctgggaagg gtctcgagtg gatgggcttt atttggcctg ttgattcttg
gactcagtat 180tctccttctt ttcagggtca ggtcaccatt agcgcggata
aaagcattag caccgcgtat 240cttcaatgga gcagcctgaa agcgagcgat
acggccatgt attattgcgc gcgttatggt 300catggtatgt atggtggtgc
tcttgatgtt tggggccaag gcaccctggt gacggttagc 360tca 363286363DNAHomo
sapiens 286caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgaaag
cctgaaaatt 60agctgcaaag gttccggata ttcctttact aattattgga ttggttgggt
gcgccagatg 120cctgggaagg gtctcgagtg gatgggcttt atttggcctg
ttgattcttg gactcagtat 180tctccttctt ttcagggtca ggtcaccatt
agcgcggata aaagcattag caccgcgtat 240cttcaatgga gcagcctgaa
agcgagcgat acggccatgt attattgcgc gcgttatggt 300catggtatgt
atggtggtgc tcttgatgtt tggggccaag gcaccctggt gacggttagc 360tca
363287363DNAHomo sapiens 287caggtgcaat tggttcagag cggcgcggaa
gtgaaaaaac cgggcgaaag cctgaaaatt 60agctgcaaag gttccggata ttcctttact
aattattgga ttggttgggt gcgccagatg 120cctgggaagg gtctcgagtg
gatgggcatt atttggccta ttgattcttt tactcagtat 180tctccttctt
ttcagggtca ggtgaccatt agcgcggata aaagcattag caccgcgtat
240cttcaatgga gcagcctgaa agcgagcgat acggccatgt attattgcgc
gcgttatggt 300catggtatgt atggtggtgc tcttgatgtt tggggccaag
gcaccctggt gacggttagc 360tca 363288363DNAHomo sapiens 288caggtgcaat
tggttcagag cggcgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt 60agctgcaaag
gttccggata ttcctttact aattattgga ttggttgggt gcgccagatg
120cctgggaagg gtctcgagtg gatgggcgtt atcatgccgt ctgatagcta
tacccgttat 180tctccgagct ttcagggcca ggtgaccatt agcgcggata
aaagcattag caccgcgtat 240cttcaatgga gcagcctgaa agcgagcgat
acggccatgt attattgcgc gcgttatggt 300catggtatgt atggtggtgc
tcttgatgtt tggggccaag gcaccctggt gacggttagc 360tca 363289363DNAHomo
sapiens 289caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgaaag
cctgaaaatt 60agctgcaaag gttccggata ttcctttact aattattgga ttggttgggt
gcgccagatg 120cctgggaagg gtctcgagtg gatgggcgtt atcatgccgt
ctgatagcta tacccgttat 180tctccgagct ttcagggcca ggtgaccatt
agcgcggata aaagcattag caccgcgtat 240cttcaatgga gcagcctgaa
agcgagcgat acggccatgt attattgcgc gcgttatggt 300catggtatgt
atggtggtgc tcttgatgtt tggggccaag gcaccctggt gacggttagc 360tca
363290363DNAHomo sapiens 290caggtgcaat tggttcagag cggcgcggaa
gtgaaaaaac cgggcgaaag cctgaaaatt 60agctgcaaag gttccggata ttcctttact
aattattgga ttggttgggt gcgccagatg 120cctgggaagg gtctcgagtg
gatgggcgtt atcatgccgt ctgatagcta tacccgttat 180tctccgagct
ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat
240cttcaatgga gcagcctgaa agcgagcgat acggccatgt attattgcgc
gcgttatggt 300catggtatgt atggtggtgc tcttgatgtt tggggccaag
gcaccctggt gacggttagc 360tca 363291363DNAHomo sapiens 291caggtgcaat
tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg 60agctgcgcgg
cctccggatt taccttttct gattatgcta tgtcttgggt gcgccaagcc
120cctgggaagg gtctcgagtg ggtgagcgct atcatgtatg attctagctc
taccttttat 180gcggatagcg
tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat
240ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc
gcgtattaat 300tatatttata agggtgttca ttttgattat tggggccaag
gcaccctggt gacggttagc 360tca 363292357DNAHomo sapiens 292caggtggaat
tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg 60agctgcaaag
cctccggata tacctttact ggtaattata ttaattgggt ccgccaagcc
120cctgggcagg gtctcgagtg gatgggcatt atcaatccgc atggtggcga
tacgaagtac 180gcgcagaagt ttcagggccg ggtgaccatg acccgtgata
ccagcattag caccgcgtat 240atggaactga gcagcctgcg tagcgaagat
acggccgtgt attattgcgc gcgttggcat 300catggtactt ggatttttga
ttattggggc caaggcaccc tggtgacggt tagctca 357293357DNAHomo sapiens
293caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag
cgtgaaagtg 60agctgcaaag cctccggata tacctttact ggtaattata ttaattgggt
ccgccaagcc 120cctgggcagg gtctcgagtg gatgggcatt attaatccta
ctaagggttg gactctttat 180gctcagaagt ttcagggtcg ggtcaccatg
acccgtgata ccagcattag caccgcgtat 240atggaactga gcagcctgcg
tagcgaagat acggccgtgt attattgcgc gcgttggcat 300catggtactt
ggatttttga ttattggggc caaggcaccc tggtgacggt tagctca
357294363DNAHomo sapiens 294caggtgcaat tggttcagag cggcgcggaa
gtgaaaaaac cgggcgaaag cctgaaaatt 60agctgcaaag gttccggata ttcctttact
aattattgga ttggttgggt gcgccagatg 120cctgggaagg gtctcgagtg
gatgggcttt atttggcctt ctgattcttg gacttcttat 180tctccttctt
ttcagggtca ggtgaccatt agcgcggata aaagcattag caccgcgtat
240cttcaatgga gcagcctgaa agcgagcgat acggccatgt attattgcgc
gcgttatggt 300catggtatgt atggtggtgc tcttgatgtt tggggccaag
gcaccctggt gacggttagc 360tca 363295357DNAHomo sapiens 295caggtgcaat
tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg 60agctgcaaag
cctccggata tacctttact ggtaattata ttaattgggt ccgccaagcc
120cctgggcagg gtctcgagtg gatgggcatt atcaatccgc atggtggcga
tacgaagtac 180gcgcagaagt ttcagggccg ggtgaccatg acccgtgata
ccagcattag caccgcgtat 240atggaactga gcagcctgcg tagcgaagat
acggccgtgt attattgcgc gcgttggcat 300catggtactt ggatttttga
ttattggggc caaggcaccc tggtgacggt tagctca 357296345DNAHomo sapiens
296caggtgcaat tggttcagtc tggcgcggaa gtgaaaaaac cgggcagcag
cgtgaaagtg 60agctgcaaag cctccggagg cactttttct tcttattatt tttcttgggt
gcgccaagcc 120cctgggcagg gtctcgagtg gatgggcggt atcattccga
agtttggctc tgcgaattac 180gcgcagaagt ttcagggccg ggtgaccatt
accgcggatg aaagcaccag caccgcgtat 240atggaactga gcagcctgcg
tagcgaagat acggccgtgt attattgcgc gcgtcgtact 300tctatggatt
attggggcca aggcaccctg gtgacggtta gctca 345297345DNAHomo sapiens
297caggtgcaat tggttcagtc tggcgcggaa gtgaaaaaac cgggcagcag
cgtgaaagtg 60agctgcaaag cctccggagg cactttttct tcttattatt tttcttgggt
gcgccaagcc 120cctgggcagg gtctcgagtg gatgggcggt atcattccga
agtttggctc tgcgaattac 180gcgcagaagt ttcagggccg ggtgaccatt
accgcggatg aaagcaccag caccgcgtat 240atggaactga gcagcctgcg
tagcgaagat acggccgtgt attattgcgc gcgtcgtact 300tctatggatt
attggggcca aggcaccctg gtgacggtta gctca 345298360DNAHomo sapiens
298caggtggaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgaaag
cctgaaaatt 60agctgcaaag gttccggata ttcctttact tcttattgga ttggttgggt
gcgccaggcc 120cctgggaagg gtctcgagtg gatgggcatt atcgatccgg
gtgatagccg tacccgttat 180tctccgagct ttcagggcca ggtgaccatt
agcgcggata aaagcattag caccgcgtat 240cttcaatgga gcagcctgaa
agcgagcgat acggccatgt attattgcgc gcgtggtcag 300ctttatggtg
gtacttatat ggatggttgg ggccaaggca ccctggtgac ggttagctca
360299363DNAHomo sapiens 299caggtgcaat tggtggaaag cggcggcggc
ctggtgcaac cgggcggcag cctgcgtctg 60agctgcgcgg cctccggatt taccttttct
gattatgcta tgtcttgggt gcgccaagcc 120cctgggaagg gtctcgagtg
ggtgagcgct atcatgtatg attctagctc taccttttat 180gcggatagcg
tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat
240ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc
gcgtattaat 300tatatttata agggtgttca ttttgattat tggggccaag
gcaccctggt gacggttagc 360tca 363300348DNAHomo sapiens 300caggtgcaat
tgcaagaaag tggtccgggc ctggtgaaac cgggcgaaac cctgagcctg 60acctgcaccg
tttccggagg cagcatttct aattattatt ggtcttggat tcgccaggcc
120cctgggaagg gtctcgagtg gattggcgag atctatcatt ctggcggtac
ctattataat 180ccgagcctga aaggccgggt gaccattagc gttgatactt
cgaaaaacca gtttagcctg 240aaactgagca gcgtgacggc ggaagatacg
gccgtgtatt attgcgcgcg tcctatggat 300aatcttcctg atatttgggg
ccaaggcacc ctggtgacgg ttagctca 348301348DNAHomo sapiens
301caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag
cctgcgtctg 60agctgcgcgg cctccggatt taccttttct tcttatggta tgtcttgggt
gcgccaagcc 120cctgggaagg gtctcgagtg ggtgagcggt atctcttatt
cttctagcgc tacctattat 180gcggatagcg tgaaaggccg ttttaccatt
tcacgtgata attcgaaaaa caccctgtat 240ctgcaaatga acagcctgcg
tgcggaagat acggccgtgt attattgcgc gcgttatctt 300tattattttg
atgtttgggg ccaaggcacc ctggtgacgg ttagctca 348302345DNAHomo sapiens
302caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag
cctgcgtctg 60agctgcgcgg cctccggatt taccttttct aattcttgga tgtcttgggt
gcgccaagcc 120cctgggaagg gtctcgagtg ggtgagcgct atcacttatt
ggggtagcaa tacctattat 180gcggatagcg tgaaaggccg ttttaccatt
tcacgtgata attcgaaaaa caccctgtat 240ctgcaaatga acagcctgcg
tgcggaagat acggccgtgt attattgcgc gcgtactaag 300ttttttgcta
attggggcca aggcaccctg gtgacggtta gctca 345303345DNAHomo sapiens
303caggtgcaat tggttcagtc tggcgcggaa gtgaaaaaac cgggcagcag
cgtgaaagtg 60agctgcaaag cctccggagg cactttttct aattattcta tttcttgggt
gcgccaagcc 120cctgggcagg gtctcgagtg gatgggccgt atcattccga
attttggcac tgcgaattac 180gcgcagaagt ttcagggccg ggtgaccatt
accgcggatg aaagcaccag caccgcgtat 240atggaactga gcagcctgcg
tagcgaagat acggccgtgt attattgcgc gcgtggtatt 300tattttgctt
tttggggcca aggcaccctg gtgacggtta gctca 345304360DNAHomo sapiens
304caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag
cgtgaaagtg 60agctgcaaag cctccggata tacctttact tcttatgctc ttcattgggt
ccgccaagcc 120cctgggcagg gtctcgagtg gatgggcatt atcaatccgc
agaatggcgg tacgaattac 180gcgcagaagt ttcagggccg ggtgaccatg
acccgtgata ccagcattag caccgcgtat 240atggaactga gcagcctgcg
tagcgaagat acggccgtgt attattgcgc gcgtaagcat 300aagtatcgta
ttggttctat ggatgtttgg ggccaaggca ccctggtgac ggttagctca
360305351DNAHomo sapiens 305caggtgcaat tggttcagag cggcgcggaa
gtgaaaaaac cgggcgaaag cctgaaaatt 60agctgcaaag gttccggata ttcctttact
aattattgga ttggttgggt gcgccagatg 120cctgggaagg gtctcgagtg
gatgggcatt atcgatccgc gtgagagctt tacccgttat 180tctccgagct
ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat
240cttcaatgga gcagcctgaa agcgagcgat acggccatgt attattgcgc
gcgttatatg 300aagggtggtt atgattattg gggccaaggc accctggtga
cggttagctc a 351306360DNAHomo sapiens 306caggtgcaat tgcaacagtc
tggtccgggc ctggtgaaac cgagccaaac cctgagcctg 60acctgtgcga tttccggaga
tagcgtgagc tctcgttctg ctgcttgggg ttggattcgc 120cagtctcctg
ggcgtggcct cgagtggctg ggccgtatcg gttatcgtag caagtggatg
180aacgattatg cggtgagcgt gaaaagccgg attaccatca acccggatac
ttcgaaaaac 240cagtttagcc tgcaactgaa cagcgtgacc ccggaagata
cggccgtgta ttattgcgcg 300cgtatgcagg gttttcagct tgattattgg
ggccaaggca ccctggtgac ggttagctca 360307345DNAHomo sapiens
307caggtgcaat tggttcagtc tggcgcggaa gtgaaaaaac cgggcagcag
cgtgaaagtg 60agctgcaaag cctccggagg cactttttct aattattctc ttcattgggt
gcgccaagcc 120cctgggcagg gtctcgagtg gatgggcggt atcgttccga
tttttggcac tgcgaattac 180gcgcagaagt ttcagggccg ggtgaccatt
accgcggatg aaagcaccag caccgcgtat 240atggaactga gcagcctgcg
tagcgaagat acggccgtgt attattgcgc gcgtacttat 300acttttgctg
tttggggcca aggcaccctg gtgacggtta gctca 345308345DNAHomo sapiens
308caggtgcaat tggttcagtc tggcgcggaa gtgaaaaaac cgggcagcag
cgtgaaagtg 60agctgcaaag cctccggagg cactttttct aattattctc ttcattgggt
gcgccaagcc 120cctgggcagg gtctcgagtg gatgggcggt atcgttccga
tttttggcac tgcgaattac 180gcgcagaagt ttcagggccg ggtgaccatt
accgcggatg aaagcaccag caccgcgtat 240atggaactga gcagcctgcg
tagcgaagat acggccgtgt attattgcgc gcgtacttat 300acttttgctg
tttggggcca aggcaccctg gtgacggtta gctca 345309342DNAHomo sapiens
309caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgcgag
cgtgaaagtg 60agctgcaaag cctccggata tacctttact atttatgata tgcattgggt
ccgccaagcc 120cctgggcagg gtctcgagtg gatgggctat atctctccgt
attctggcga tacgaattac 180gcgcagaagt ttcagggccg ggtgaccatg
acccgtgata ccagcattag caccgcgtat 240atggaactga gcagcctgcg
tagcgaagat acggccgtgt attattgcgc gcgtggttgg 300caggattttt
ggggccaagg caccctggtg acggttagct ca 342310378DNAHomo sapiens
310caggtgcaat tgcaacagtc tggtccgggc ctggtgaaac cgagccaaac
cctgagcctg 60acctgtgcga tttccggaga tagcgtgagc tctaattctg ctgcttgggg
ttggattcgc 120cagtctcctg ggcgtggcct cgagtggctg ggccgtatct
cttatcgtag ccgttggtat 180aacaattatg cggtgagcgt gaaaagccgg
attaccatca acccggatac ttcgaaaaac 240cagtttagcc tgcaactgaa
cagcgtgacc ccggaagata cggccgtgta ttattgcgcg 300cgttattatt
ctgatcattt tggtctttat ccttattttg attattgggg ccaaggcacc
360ctggtgacgg ttagctca 378311378DNAHomo sapiens 311caggtgcaat
tggttcagag cggcgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt 60agctgcaaag
gttccggata ttcctttaat acttcttgga tttgggtgcg ccagatgcct
120gggaagggtc tcgagtggat gggcattatc catccgggtc atagctatac
ccgttattct 180ccgagctttc agggccaggt gaccattagc gcggataaaa
gcattagcac cgcgtatctt 240caatggagca gcctgaaagc gagcgatacg
gccatgtatt attgcgcgcg tggtgatggt 300ggtccttctt ctcagggtaa
ttattttggt tgggtttatg atgtttgggg ccaaggcacc 360ctggtgacgg ttagctca
378312375DNAHomo sapiens 312caggtgcaat tgcaacagtc tggtccgggc
ctggtgaaac cgagccaaac cctgagcctg 60acctgtgcga tttccggaga tagcgtgagc
tctaattctg ctgcttggtc ttggattcgc 120cagtctcctg ggcgtggcct
cgagtggctg ggccgtatct attatcgtag caagaagtgg 180tataacgatt
atgcggtgag cgtgaaaagc cggattacca tcaacccgga tacttcgaaa
240aaccagttta gcctgcaact gaacagcgtg accccggaag atacggccgt
gtattattgc 300gcgcgtaatt attctggtcc tatgtattat tatggtgatg
tttggggcca aggcaccctg 360gtgacggtta gctca 375313369DNAHomo sapiens
313caggtgcaat tgcaacagtc tggtccgggc ctggtgaaac cgagccaaac
cctgagcctg 60acctgtgcga tttccggaga tagcgtgagc tctaattctg ctgcttggtc
ttggattcgc 120cagtctcctg ggcgtggcct cgagtggctg ggccgtatcc
agtatcgtag caagtggtat 180aacgcttatg cggtgagcgt gaaaagccgg
attaccatca acccggatac ttcgaaaaac 240cagtttagcc tgcaactgaa
cagcgtgacc ccggaagata cggccgtgta ttattgcgcg 300cgtggttttc
atggttctac tatgtatttt gatgtttggg gccaaggcac cctggtgacg 360gttagctca
369314351DNAHomo sapiens 314caggtgcaat tggttcagag cggcgcggaa
gtgaaaaaac cgggcgaaag cctgaaaatt 60agctgcaaag gttccggata ttcctttact
acttattgga ttggttgggt gcgccaagcc 120cctgggaagg gtctcgagtg
gatgggcttt atctatccgg ataagagcta taccaattat 180tctccgagct
ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat
240cttcaatgga gcagcctgaa agcgagcgat acggccatgt attattgcgc
gcgtggtctt 300ggtggttctt ttgatgtttg gggccaaggc accctggtga
cggttagctc a 351315369DNAHomo sapiens 315caggtgcaat tgcaacagtc
tggtccgggc ctggtgaaac cgagccaaac cctgagcctg 60acctgtgcga tttccggaga
tagcgtgagc tctaattctg cttcttggtc ttggattcgc 120cagtctcctg
ggcgtggcct cgagtggctg ggccgtatct attatcgtag ccagtggtat
180aacgattatg cggtgagcgt gaaaagccgg attaccatca acccggatac
ttcgaaaaac 240cagtttagcc tgcaactgaa cagcgtgacc ccggaagata
cggccgtgta ttattgcgcg 300cgtggttgga ttactggttg gcgtattttt
gattattggg gccaaggcac cctggtgacg 360gttagctca 369316360DNAHomo
sapiens 316caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag
cctgcgtctg 60agctgcgcgg cctccggatt taccttttct acttatgcta tgtcttgggt
gcgccaagcc 120cctgggaagg gtctcgagtg ggtgagcttt atctctggtt
atggtagctc tacctattat 180gcggatagcg tgaaaggccg ttttaccatt
tcacgtgata attcgaaaaa caccctgtat 240ctgcaaatga acagcctgcg
tgcggaagat acggccgtgt attattgcgc gcgtaagatg 300tattggtggt
ctgatggttt tgattattgg ggccaaggca ccctggtgac ggttagctca
360317363DNAHomo sapiens 317caggtgcaat tggtggaaag cggcggcggc
ctggtgcaac cgggcggcag cctgcgtctg 60agctgcgcgg cctccggatt taccttttct
cgttatgcta tttcttgggt gcgccaagcc 120cctgggaagg gtctcgagtg
ggtgagctct atctctggtg gtggtagcaa gaccttttat 180gcggatagcg
tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat
240ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc
gcgttatcct 300ggtcctactg gtcatgtttt ttttgatatt tggggccaag
gcaccctggt gacggttagc 360tca 363318348DNAHomo sapiens 318caggtgcaat
tggttcagtc tggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg 60agctgcaaag
cctccggagg cactttttct tcttattata tttcttgggt gcgccaagcc
120cctgggcagg gtctcgagtg gatgggcggt atcattccga agtttggcac
tgcgaattac 180gcgcagaagt ttcagggccg ggtgaccatt accgcggatg
aaagcaccag caccgcgtat 240atggaactga gcagcctgcg tagcgaagat
acggccgtgt attattgcgc gcgtactatt 300ggtatttatg attcttgggg
ccaaggcacc ctggtgacgg ttagctca 348319345DNAHomo sapiens
319caggtgcaat tggttcagtc tggcgcggaa gtgaaaaaac cgggcagcag
cgtgaaagtg 60agctgcaaag cctccggagg cactttttct tctcatgcta tttcttgggt
gcgccaagcc 120cctgggcagg gtctcgagtg gatgggcaat atcatgccga
tttttggcgt tgcgaattac 180gcgcagaagt ttcagggccg ggtgaccatt
accgcggatg aaagcaccag caccgcgtat 240atggaactga gcagcctgcg
tagcgaagat acggccgtgt attattgcgc gcgtgagatg 300cgtcttgctt
attggggcca aggcaccctg gtgacggtta gctca 345320378DNAHomo sapiens
320caggtgcaat tgcaacagtc tggtccgggc ctggtgaaac cgagccaaac
cctgagcctg 60acctgtgcga tttccggaga tagcgtgagc tctaatactg ctgcttggtc
ttggattcgc 120cagtctcctg ggcgtggcct cgagtggctg ggccgtatcc
gttatcgtag caagtggtat 180aacgattatg cggtgagcgt gaaaagccgg
attaccatca acccggatac ttcgaaaaac 240cagtttagcc tgcaactgaa
cagcgtgacc ccggaagata cggccgtgta ttattgcgcg 300cgtggttatc
atcagggtct ttatggtaat catatgtttg atgtttgggg ccaaggcacc
360ctggtgacgg ttagctca 378321354DNAHomo sapiens 321caggtgcaat
tgaaagaaag cggcccggcc ctggtgaaac cgacccaaac cctgaccctg 60acctgtacct
tttccggatt tagcctgtct tcttctggtg ttggtgtgtc ttggattcgc
120cagccgcctg ggaaagccct cgagtggctg gctcttatcg attgggatga
tgataagtct 180tatagcacca gcctgaaaac gcgtctgacc attagcaaag
atacttcgaa aaatcaggtg 240gtgctgacta tgaccaacat ggacccggtg
gatacggcca cctattattg cgcgcgtatt 300cagggttgga attatgatgt
ttggggccaa ggcaccctgg tgacggttag ctca 354322360DNAHomo sapiens
322caggtgcaat tgcaacagtc tggtccgggc ctggtgaaac cgagccaaac
cctgagcctg 60acctgtgcga tttccggaga tagcgtgagc tcttcttctg ctgcttggtc
ttggattcgc 120cagtctcctg ggcgtggcct cgagtggctg ggccgtatcg
gtcagcgtag caagtggtat 180aacgattatg cggtgagcgt gaaaagccgg
attaccatca acccggatac ttcgaaaaac 240cagtttagcc tgcaactgaa
cagcgtgacc ccggaagata cggccgtgta ttattgcgcg 300cgttctcgtt
ttggttattt tgatgtttgg ggccaaggca ccctggtgac ggttagctca
360323354DNAHomo sapiens 323caggtgcaat tggtggaaag cggcggcggc
ctggtgcaac cgggcggcag cctgcgtctg 60agctgcgcgg cctccggatt taccttttct
tctcattatt cttgggtgcg ccaagcccct 120gggaagggtc tcgagtgggt
gagcactatc tcttctaatg gtagctatac ctattatgcg 180gatagcgtga
aaggccgttt taccatttca cgtgataatt cgaaaaacac cctgtatctg
240caaatgaaca gcctgcgtgc ggaagatacg gccgtgtatt attgcgcgcg
ttttgttgct 300cgtcttaatg tttttgatta ttggggccaa ggcaccctgg
tgacggttag ctca 354324345DNAHomo sapiens 324caggtgcaat tggttcagtc
tggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg 60agctgcaaag cctccggagg
cactttttct aattatacta tttcttgggt gcgccaagcc 120cctgggcagg
gtctcgagtg gatgggcaat atcattccgg cttttggcta tgcgaattac
180gcgcagaagt ttcagggccg ggtgaccatt accgcggatg aaagcaccag
caccgcgtat 240atggaactga gcagcctgcg tagcgaagat acggccgtgt
attattgcgc gcgtaagttt 300acttttgatg tttggggcca aggcaccctg
gtgacggtta gctca 345325354DNAHomo sapiens 325caggtgcaat tggtggaaag
cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg 60agctgcgcgg cctccggatt
taccttttct tcttattatt cttgggtgcg ccaagcccct 120gggaagggtc
tcgagtgggt gagcaatatc tctggtaatg gtagctctac ctattatgcg
180gatagcgtga aaggccgttt taccatttca cgtgataatt cgaaaaacac
cctgtatctg 240caaatgaaca gcctgcgtgc ggaagatacg gccgtgtatt
attgcgcgcg tcttattgct 300actcttggta cttttgatta ttggggccaa
ggcaccctgg tgacggttag ctca 354326360DNAHomo sapiens 326caggtgcaat
tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg 60agctgcgcgg
cctccggatt taccttttct aattatggta ttcattgggt gcgccaagcc
120cctgggaagg gtctcgagtg ggtgagctat atccgttctg gttctagcga
tacctattat 180gcggatagcg tgaaaggccg ttttaccatt tcacgtgata
attcgaaaaa caccctgtat 240ctgcaaatga acagcctgcg tgcggaagat
acggccgtgt attattgcgc gcgtactgct 300cctgctggtc atggtgtttt
tgctaattgg ggccaaggca ccctggtgac ggttagctca 360327330DNAHomo
sapiens 327gatatcgtgc tgacccagag cccggcgacc ctgagcctgt ctccgggcga
acgtgcgacc 60ctgagctgca gagcgagcca gtctgttcgt tcttctcgtc tggcttggta
ccagcagaaa 120ccaggtcaag caccgcgtct attaatttat ggtgcttcta
agcgtgcaac tggggtcccg 180gcgcgtttta gcggctctgg atccggcacg
gattttaccc tgaccattag cagcctggaa 240cctgaagact ttgcgactta
ttattgccag cagtattatg attttcctcc tacctttggc 300cagggtacga
aagttgaaat taaacgtacg 330328333DNAHomo sapiens 328gatatcgtgc
tgacccagag cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc 60ctgagctgca
gagcgagcca gtctgttcgt tcttctcgtc tggcttggta ccagcagaaa
120ccaggtcaag caccgcgtct attaatttat ggtgcttcta agcgtgcaac
tggggtcccg 180gcgcgtttta gcggctctgg atccggcacg gattttaccc
tgaccattag cagcctggaa 240cctgaagact ttgcggtgta ttattgccag
cagtattctc atgatccttc tggtaccttt 300ggccagggta cgaaagttga
aattaaacgt acg 333329330DNAHomo sapiens
329gatatcgtgc tgacccagag cccggcgacc ctgagcctgt ctccgggcga
acgtgcgacc 60ctgagctgca gagcgagcca gtctgttcgt tcttctcgtc tggcttggta
ccagcagaaa 120ccaggtcaag caccgcgtct attaatttat ggtgcttcta
agcgtgcaac tggggtcccg 180gcgcgtttta gcggctctgg atccggcacg
gattttaccc tgaccattag cagcctggaa 240cctgaagact ttgcgactta
ttattgccag cagtattatg attttcctcc tacctttggc 300cagggtacga
aagttgaaat taaacgtacg 330330330DNAHomo sapiens 330gatatcgtgc
tgacccagag cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc 60ctgagctgca
gagcgagcca gtctgttcgt tcttctcgtc tggcttggta ccagcagaaa
120ccaggtcaag caccgcgtct attaatttat ggtgcttcta agcgtgcaac
tggggtcccg 180gcgcgtttta gcggctctgg atccggcacg gattttaccc
tgaccattag cagcctggaa 240cctgaagact ttgcgactta ttattgccag
cagtattatg attttcctcc tacctttggc 300cagggtacga aagttgaaat
taaacgtacg 330331330DNAHomo sapiens 331gatatcgtgc tgacccagag
cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc 60ctgagctgca gagcgagcca
gtctgttcgt tcttctcgtc tggcttggta ccagcagaaa 120ccaggtcaag
caccgcgtct attaatttat ggtgcttcta agcgtgcaac tggggtcccg
180gcgcgtttta gcggctctgg atccggcacg gattttaccc tgaccattag
cagcctggaa 240cctgaagact ttgcggtgta ttattgccag cagttttatt
ctaagcctat tacctttggc 300cagggtacga aagttgaaat taaacgtacg
330332333DNAHomo sapiens 332gatatcgtgc tgacccagag cccggcgacc
ctgagcctgt ctccgggcga acgtgcgacc 60ctgagctgca gagcgagcca gtctgttcgt
tcttctcgtc tggcttggta ccagcagaaa 120ccaggtcaag caccgcgtct
attaatttat ggtgcttcta agcgtgcaac tggggtcccg 180gcgcgtttta
gcggctctgg atccggcacg gattttaccc tgaccattag cagcctggaa
240cctgaagact ttgcggtgta ttattgccag cagtattctc atgatccttc
tggtaccttt 300ggccagggta cgaaagttga aattaaacgt acg 333333333DNAHomo
sapiens 333gatatcgtgc tgacccagag cccggcgacc ctgagcctgt ctccgggcga
acgtgcgacc 60ctgagctgca gagcgagcca gtctgttcgt tcttctcgtc tggcttggta
ccagcagaaa 120ccaggtcaag caccgcgtct attaatttat ggtgcttcta
agcgtgcaac tggggtcccg 180gcgcgtttta gcggctctgg atccggcacg
gattttaccc tgaccattag cagcctggaa 240cctgaagact ttgcggtgta
ttattgccag cagtattctc aggatccttc ttctaccttt 300ggccagggta
cgaaagttga aattaaacgt acg 333334330DNAHomo sapiens 334gatatcgtgc
tgacccagag cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc 60ctgagctgca
gagcgagcca gattgtttcc ggttatctgg cttggtacca gcagaaacca
120ggtcaagcac cgcgtctatt aatttatggt gcttcttctc gtgcaactgg
ggtcccggcg 180cgttttagcg gctctggatc cggcacggat tttaccctga
ccattagcag cctggaacct 240gaagactttg cggtgtatta ttgccagcag
tggtctcttc gttctccttt tacctttggc 300cagggtacga aagttgaaat
taaacgtacg 330335333DNAHomo sapiens 335gatatcgtgc tgacccagcc
gccttcagtg agtggcgcac caggtcagcg tgtgaccatc 60tcgtgtagcg gcagcagcag
caacattggt tctaattatg tgtcttggta ccagcagttg 120cccgggacgg
cgccgaaact tctgatttat aatgataatc agcgtccctc aggcgtgccg
180gatcgtttta gcggatccaa aagcggcacc agcgcgagcc ttgcgattac
gggcctgcaa 240agcgaagacg aagcggatta ttattgctct acttatgatc
gtcgtacttt ttctgtgttt 300ggcggcggca cgaagttaac cgtcctaggt cag
333336333DNAHomo sapiens 336gatatcgtgc tgacccagcc gccttcagtg
agtggcgcac caggtcagcg tgtgaccatc 60tcgtgtagcg gcagcagcag caacattggt
tctaattatg tgtcttggta ccagcagttg 120cccgggacgg cgccgaaact
tctgatttat aatgataatc agcgtccctc aggcgtgccg 180gatcgtttta
gcggatccaa aagcggcacc agcgcgagcc ttgcgattac gggcctgcaa
240agcgaagacg aagcggatta ttattgctct acttatgatc gtcgtacttt
ttctgtgttt 300ggcggcggca cgaagttaac cgtcctaggt cag 333337330DNAHomo
sapiens 337gatatcgtgc tgacccagag cccggcgacc ctgagcctgt ctccgggcga
acgtgcgacc 60ctgagctgca gagcgagcca gtctgttcgt tcttctcgtc tggcttggta
ccagcagaaa 120ccaggtcaag caccgcgtct attaatttat ggtgcttcta
agcgtgcaac tggggtcccg 180gcgcgtttta gcggctctgg atccggcacg
gattttaccc tgaccattag cagcctggaa 240cctgaagact ttgcgactta
ttattgccag cagtattatg attttcctcc tacctttggc 300cagggtacga
aagttgaaat taaacgtacg 330338336DNAHomo sapiens 338gatatcgtgc
tgacccagcc gccttcagtg agtggcgcac caggtcagcg tgtgaccatc 60tcgtgtagcg
gcagcagcag caacattggt tctaattatg tgtcttggta ccagcagttg
120cccgggacgg cgccgaaact tctgatttat aatgataatc agcgtccctc
aggcgtgccg 180gatcgtttta gcggatccaa aagcggcacc agcgcgagcc
ttgcgattac gggcctgcaa 240agcgaagacg aagcggatta ttattgctct
tcttgggatc gtgctgatgg ttcttatgtg 300tttggcggcg gcacgaagtt
aaccgtccta ggtcag 336339339DNAHomo sapiens 339gatatcgcac tgacccagcc
agcttcagtg agcggctcac caggtcagag cattaccatc 60tcgtgtacgg gtactagcag
cgatgttggt ggttataatt atgtgtcttg gtaccagcag 120catcccggga
aggcgccgaa acttatgatt tattctgttt ctaagcgtcc ctcaggcgtg
180agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat
tagcggcctg 240caagcggaag acgaagcgga ttattattgc ggtgcttggg
ctcatatgtc tcttggtaag 300gtgtttggcg gcggcacgaa gttaaccgtt cttggccag
339340339DNAHomo sapiens 340gatatcgcac tgacccagcc agcttcagtg
agcggctcac caggtcagag cattaccatc 60tcgtgtacgg gtactagcag cgatgttggt
ggttataatt atgtgtcttg gtaccagcag 120catcccggga aggcgccgaa
acttatgatt tattctgttt ctaagcgtcc ctcaggcgtg 180agcaaccgtt
ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg
240caagcggaag acgaagcgga ttattattgc gctacttggg atcattctca
gatgggtaag 300gtgtttggcg gcggcacgaa gttaaccgtc ctaggtcag
339341339DNAHomo sapiens 341gatatcgcac tgacccagcc agcttcagtg
agcggctcac caggtcagag cattaccatc 60tcgtgtacgg gtactagcag cgatgttggt
ggttataatt atgtgtcttg gtaccagcag 120catcccggga aggcgccgaa
acttatgatt tattctgttt ctaagcgtcc ctcaggcgtg 180agcaaccgtt
ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg
240caagcggaag acgaagcgga ttattattgc gctacttggg atcattctca
gatgggtaag 300gtgtttggcg gcggcacgaa gttaaccgtc ctaggtcag
339342327DNAHomo sapiens 342gatatcgtgc tgacccagag cccggcgacc
ctgagcctgt ctccgggcga acgtgcgacc 60ctgagctgca gagcgagcca gattgtttcc
ggttatctgg cttggtacca gcagaaacca 120ggtcaagcac cgcgtctatt
aatttatggt gcttcttctc gtgcaactgg ggtcccggcg 180cgttttagcg
gctctggatc cggcacggat tttaccctga ccattagcag cctggaacct
240gaagactttg cgacttatta ttgccagcag tattataatt tttcttttac
ctttggccag 300ggtacgaaag ttgaaattaa acgtacg 327343327DNAHomo
sapiens 343gatatccaga tgacccagag cccgtctagc ctgagcgcga gcgtgggtga
tcgtgtgacc 60attacctgca gagcgagcca gaatattggt tcttatctga attggtacca
gcagaaacca 120ggtaaagcac cgaaactatt aatttataat tcttctactt
tgcaaagcgg ggtcccgtcc 180cgttttagcg gctctggatc cggcactgat
tttaccctga ccattagcag cctgcaacct 240gaagactttg cgacttatta
ttgccagcag cgttctaata tgcctattac ctttggccag 300ggtacgaaag
ttgaaattaa acgtacg 327344333DNAHomo sapiens 344gatatcgcac
tgacccagcc agcttcagtg agtggcgcac caggtcagcg tgtgaccatc 60tcgtgtacgg
gtactagcag cgatgttggt gcttctgata ctgtgacttg gtaccagcag
120catcccggga aggcgccgaa acttatgatt tatgctgtta ataagcgtcc
ctcaggcgtg 180agcaaccgtt ttagcggatc caaaagcggc aacaccgcga
gcctgaccat tagcggcctg 240caagcggaag acgaagcgga ttattattgc
gcttctcgtg attcttcttc tatggtgttt 300ggcggcggca cgaagttaac
cgttcttggc cag 333345342DNAHomo sapiens 345gatatcgtga tgacccagag
cccactgagc ctgccagtga ctccgggcga gcctgcgagc 60attagctgca gaagcagcca
aagcctgctt cattctaatg gctatactta tctgtcttgg 120taccttcaaa
aaccaggtca aagcccgcag ctattaattt atcttggttc taagcgtgcc
180agtggggtcc cggatcgttt tagcggctct ggatccggca ccgattttac
cctgaaaatt 240agccgtgtgg aagctgaaga cgtgggcgtg tattattgcc
agcagtatta tgattcttct 300tctacctttg gccagggtac gaaagttgaa
attaaacgta cg 342346336DNAHomo sapiens 346gatatcgtgc tgacccagcc
gccttcagtg agtggcgcac caggtcagcg tgtgaccatc 60tcgtgtagcg gcagcagcag
caacattggt cctaattatg tgtcttggta ccagcagttg 120cccgggacgg
cgccgaaact tctgattcat ggtaatgcta atcgtccctc aggcgtgccg
180gatcgtttta gcggatccaa aagcggcacc agcgcgagcc ttgcgattac
gggcctgcaa 240agcgaagacg aagcggatta ttattgccag tcttatgatt
tttttactaa ttcttctgtg 300tttggcggcg gcacgaagtt aaccgttctt ggccag
336347330DNAHomo sapiens 347gatatcgtgc tgacccagag cccggcgacc
ctgagcctgt ctccgggcga acgtgcgacc 60ctgagctgca gagcgagcca gtctcttact
tctaatcagc tggcttggta ccagcagaaa 120ccaggtcaag caccgcgtct
attaatttat gattcttcta atcgtgcaac tggggtcccg 180gcgcgtttta
gcggctctgg atccggcacg gattttaccc tgaccattag cagcctggaa
240cctgaagact ttgcggttta ttattgccag cagtatggtt cttttcctgc
tacctttggc 300cagggtacga aagttgaaat taaacgtacg 330348339DNAHomo
sapiens 348gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag
cattaccatc 60tcgtgtacgg gtactagcag cgatgttggt ggtaataatt ttgtgtcttg
gtaccagcag 120catcccggga aggcgccgaa acttatgatt tattatggtg
attctcgtcc ctcaggcgtg 180agcaaccgtt ttagcggatc caaaagcggc
aacaccgcga gcctgaccat tagcggcctg 240caagcggaag acgaagcgga
ttattattgc cagtcttggg atgctcctat gggtatgtgg 300gtgtttggcg
gcggcacgaa gttaaccgtt cttggccag 339349339DNAHomo sapiens
349gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag
cattaccatc 60tcgtgtacgg gtactagcag cgatgttggt ggtaataatt ttgtgtcttg
gtaccagcag 120catcccggga aggcgccgaa acttatgatt tattatggtg
attctcgtcc ctcaggcgtg 180agcaaccgtt ttagcggatc caaaagcggc
aacaccgcga gcctgaccat tagcggcctg 240caagcggaag acgaagcgga
ttattattgc cagtcttggg atgctcctat gggtatgtgg 300gtgtttggcg
gcggcacgaa gttaaccgtt cttggccag 339350336DNAHomo sapiens
350gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag
cattaccatc 60tcgtgtacgg gtactagcag cgatgttggt aattttaatt atgtgaattg
gtaccagcag 120catcccggga aggcgccgaa acttatgatt tattctgttt
cttctcgtcc ctcaggcgtg 180agcaaccgtt ttagcggatc caaaagcggc
aacaccgcga gcctgaccat tagcggcctg 240caagcggaag acgaagcgga
ttattattgc ggtgcttata ctactgatac tctttctgtg 300tttggcggcg
gcacgaagtt aaccgttctt ggccag 336351330DNAHomo sapiens 351gatatcgtgc
tgacccagag cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc 60ctgagctgca
gagcgagcca gtctgttact tctaattatc tggcttggta ccagcagaaa
120ccaggtcaag caccgcgtct attaatttat ggttcttctt ctcgtgcaac
tggggtcccg 180gcgcgtttta gcggctctgg atccggcacg gattttaccc
tgaccattag cagcctggaa 240cctgaagact ttgcggttta ttattgccag
cagtattctg atattcctgc tacctttggc 300cagggtacga aagttgaaat
taaacgtacg 330352327DNAHomo sapiens 352gatatccaga tgacccagag
cccgtctagc ctgagcgcga gcgtgggtga tcgtgtgacc 60attacctgca gagcgagcca
gtctattaat cgttctctga cttggtacca gcagaaacca 120ggtaaagcac
cgaaactatt aatttatgct gcttctaatt tgcaaagcgg ggtcccgtcc
180cgttttagcg gctctggatc cggcactgat tttaccctga ccattagcag
cctgcaacct 240gaagactttg cggtttatta ttgccttcag gtttataatc
ttcctcttac ctttggccag 300ggtacgaaag ttgaaattaa acgtacg
327353339DNAHomo sapiens 353gatatcgcac tgacccagcc agcttcagtg
agcggctcac caggtcagag cattaccatc 60tcgtgtacgg gtactagcag cgatattggt
ggttttaatt atgtgtcttg gtaccagcag 120catcccggga aggcgccgaa
acttatgatt tatgatgttt ctaatcgtcc ctcaggcgtg 180agcaaccgtt
ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg
240caagcggaag acgaagcgga ttattattgc tctacttatg atgatgatca
gcaggatgct 300gtgtttggcg gcggcacgaa gttaaccgtt cttggccag
339354330DNAHomo sapiens 354gatatcgaac tgacccagcc gccttcagtg
agcgttgcac caggtcagac cgcgcgtatc 60tcgtgtagcg gcgataatat tcctaatttt
tatgttcatt ggtaccagca gaaacccggg 120caggcgccag ttcttgtgat
ttatgaggat tctgatcgtc cctcaggcat cccggaacgc 180tttagcggat
ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa
240gacgaagcgg attattattg ccagtcttat gataagccta ctttttctgg
tgtgtttggc 300ggcggcacga agttaaccgt tcttggccag 330355339DNAHomo
sapiens 355gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag
cattaccatc 60tcgtgtacgg gtactagcag cgatattggt cgttatcatt atgtgtcttg
gtaccagcag 120catcccggga aggcgccgaa agttatgatt tattctgttt
ctaagcgtcc ctcaggcgtg 180agcaaccgtt ttagcggatc caaaagcggc
aacaccgcga gcctgaccat tagcggcctg 240caagcggaag acgaagcgga
ttattattgc tctgcttatg atactaataa ttatctttct 300gtgtttggcg
gcggcacgaa gttaaccgtt cttggccag 339356324DNAHomo sapiens
356gatatcgtgc tgacccagcc gccttcagtg agtggcgcac caggtcagcg
tgtgaccatc 60tcgtgtagcg gcagcagcag caacattggt aataattctg tgaattggta
ccagcagttg 120cccgggacgg cgccgaaact tctgatttat aataatcagc
gtccctcagg cgtgccggat 180cgttttagcg gatccaaaag cggcaccagc
gcgagccttg cgattacggg cctgcaaagc 240gaagacgaag cggattatta
ttgccaggct tatgcttcta atattgtgtt tggcggcggc 300acgaagttaa
ccgttcttgg ccag 324357333DNAHomo sapiens 357gatatcgcac tgacccagcc
agcttcagtg agcggctcac caggtcagag cattaccatc 60tcgtgtacgg gtactagcag
cgatgttggt gattataatt atgtgtcttg gtaccagcag 120catcccggga
aggcgccgaa acttatgatt tatcgtgttg ataatcgtcc ctcaggcgtg
180agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat
tagcggcctg 240caagcggaag acgaagcgga ttattattgc cagtcttggg
ttggtccttc tactgtgttt 300ggcggcggca cgaagttaac cgttcttggc cag
333358333DNAHomo sapiens 358gatatcgtgc tgacccagcc gccttcagtg
agtggcgcac caggtcagcg tgtgaccatc 60tcgtgtagcg gcagcagcag caacattggt
aataattatg tgtcttggta ccagcagttg 120cccgggacgg cgccgaaact
tctgatttat tctaattctc agcgtccctc aggcgtgccg 180gatcgtttta
gcggatccaa aagcggcacc agcgcgagcc ttgcgattac gggcctgcaa
240agcgaagacg aagcggatta ttattgccag tcttatgatc ataattctta
tactgtgttt 300ggcggcggca cgaagttaac cgttcttggc cag 333359324DNAHomo
sapiens 359gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac
cgcgcgtatc 60tcgtgtagcg gcgataatct tcgttctaag tatgctcatt ggtaccagca
gaaacccggg 120caggcgccag ttcttgtgat ttattctaag gataatcgtc
cctcaggcat cccggaacgc 180tttagcggat ccaacagcgg caacaccgcg
accctgacca ttagcggcac tcaggcggaa 240gacgaagcgg attattattg
ctcttcttgg gctcatgatc ataaggtgtt tggcggcggc 300acgaagttaa
ccgttcttgg ccag 324360330DNAHomo sapiens 360gatatcgaac tgacccagcc
gccttcagtg agcgttgcac caggtcagac cgcgcgtatc 60tcgtgtagcg gcgataatat
tggttctaag gttgctactt ggtaccagca gaaacccggg 120caggcgccag
ttcttgtgat ttattatgat aatgatcgtc cctcaggcat cccggaacgc
180tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac
tcaggcggaa 240gacgaagcgg attattattg ccagtcttat gatggtcaga
tgtctacttc tgtgtttggc 300ggcggcacga agttaaccgt tcttggccag
330361339DNAHomo sapiens 361gatatcgcac tgacccagcc agcttcagtg
agcggctcac caggtcagag cattaccatc 60tcgtgtacgg gtactagcag cgatgttggt
ggttataatt atgtgtcttg gtaccagcag 120catcccggga aggcgccgaa
acttatgatt tattctgtta ataatcgtcc ctcaggcgtg 180agcaaccgtt
ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg
240caagcggaag acgaagcgga ttattattgc tctacttatg atcatacttc
ttctggtttt 300gtgtttggcg gcggcacgaa gttaaccgtt cttggccag
339362333DNAHomo sapiens 362gatatcgcac tgacccagcc agcttcagtg
agcggctcac caggtcagag cattaccatc 60tcgtgtacgg gtactagcag cgatattggt
cattttaatt atgtgtcttg gtaccagcag 120catcccggga aggcgccgaa
acttatgatt tattctgtta tttctcgtcc ctcaggcgtg 180agcaaccgtt
ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg
240caagcggaag acgaagcgga ttattattgc gcttctttta cttttccttc
tcttgtgttt 300ggcggcggca cgaagttaac cgttcttggc cag 333363336DNAHomo
sapiens 363gatatcgtgc tgacccagcc gccttcagtg agtggcgcac caggtcagcg
tgtgaccatc 60tcgtgtagcg gcagcagcag caacattggt tctcatactg tgaattggta
ccagcagttg 120cccgggacgg cgccgaaact tctgatttat gatgttaata
agcgtccctc aggcgtgccg 180gatcgtttta gcggatccaa aagcggcacc
agcgcgagcc ttgcgattac gggcctgcaa 240agcgaagacg aagcggatta
ttattgcgct tcttgggatt ctgttcaggt ttctcctgtg 300tttggcggcg
gcacgaagtt aaccgttctt ggccag 336364333DNAHomo sapiens 364gatatcgtgc
tgacccagcc gccttcagtg agtggcgcac caggtcagcg tgtgaccatc 60tcgtgtagcg
gcagcagcag caacattggt aataatcgtg tgtcttggta ccagcagttg
120cccgggacgg cgccgaaact tctgatttat ggtaataata agcgtccctc
aggcgtgccg 180gatcgtttta gcggatccaa aagcggcacc agcgcgagcc
ttgcgattac gggcctgcaa 240agcgaagacg aagcggatta ttattgctct
gcttgggatc ttcttgaggt ttatgtgttt 300ggcggcggca cgaagttaac
cgttcttggc cag 333365333DNAHomo sapiens 365gatatcgcac tgacccagcc
agcttcagtg agcggctcac caggtcagag cattaccatc 60tcgtgtacgg gtactagcag
cgatattggt acttataatc atgtgtcttg gtaccagcag 120catcccggga
aggcgccgaa acttatgatt tataatgtta ataagcgtcc ctcaggcgtg
180agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat
tagcggcctg 240caagcggaag acgaagcgga ttattattgc tctgcttatg
ctccttctgc tgttgtgttt 300ggcggcggca cgaagttaac cgttcttggc cag
333366339DNAHomo sapiens 366gatatcgtgc tgacccagcc gccttcagtg
agtggcgcac caggtcagcg tgtgaccatc 60tcgtgtacgg gcagcagcag caacattggt
attggttatg atgtgaattg gtaccagcag 120ttgcccggga cggcgccgaa
acttctgatt tataagaata ctaatcgtcc ctcaggcgtg 180ccggatcgtt
ttagcggatc caaaagcggc accagcgcga gccttgcgat tacgggcctg
240caaagcgaag acgaagcgga ttattattgc tcttcttatg attcttttca
tcatggtatt 300gtgtttggcg gcggcacgaa gttaaccgtt cttggccag
339367339DNAHomo sapiens 367gatatcgcac tgacccagcc agcttcagtg
agcggctcac caggtcagag cattaccatc 60tcgtgtacgg gtactagcag cgatcttggt
ggttattctt atgtgtcttg gtaccagcag 120catcccggga aggcgccgaa
acttatgatt tataatgtta ataatcgtcc ctcaggcgtg 180agcaaccgtt
ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg
240caagcggaag acgaagcgga ttattattgc tcttcttatg attatgtttc
ttctgatact 300gtgtttggcg gcggcacgaa gttaaccgtt cttggccag
339368339DNAHomo sapiens 368gatatcgcac tgacccagcc agcttcagtg
agcggctcac caggtcagag cattaccatc 60tcgtgtacgg gtactagcag cgatgttggt
ggttataatt atgtgtcttg gtaccagcag 120catcccggga aggcgccgaa
agttatgatt tatggtgtta ctaagcgtcc ctcaggcgtg 180agcaaccgtt
ttagcggatc caaaagcggc aacaccgcga
gcctgaccat tagcggcctg 240caagcggaag acgaagcgga ttattattgc
cagacttatg atgagcatgg ttttcatatt 300gtgtttggcg gcggcacgaa
gttaaccgtt cttggccag 339369336DNAHomo sapiens 369gatatcgtgc
tgacccagcc gccttcagtg agtggcgcac caggtcagcg tgtgaccatc 60tcgtgtagcg
gcagcagcag caacattggt aattatcgtg tgtcttggta ccagcagttg
120cccgggacgg cgccgaaact tctgatttat ggtaataata agcgtccctc
aggcgtgccg 180gatcgtttta gcggatccaa aagcggcacc agcgcgagcc
ttgcgattac gggcctgcaa 240agcgaagacg aagcggatta ttattgctct
acttatactg gtcttccttt tactactgtg 300tttggcggcg gcacgaagtt
aaccgttctt ggccag 336370327PRTHomo sapiens 370Glu Val Glu Lys Thr
Ala Cys Pro Ser Gly Lys Lys Ala Arg Glu Ile 1 5 10 15 Asp Glu Ser
Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu Ala Cys Val 20 25 30 Asp
Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn Ala Ile Pro 35 40
45 Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu Leu
50 55 60 Tyr Pro Gln Gly Tyr Pro Glu Ser Val Ile Gln His Leu Gly
Tyr Leu 65 70 75 80 Phe Leu Lys Met Ser Pro Glu Asp Ile Arg Lys Trp
Asn Val Thr Ser 85 90 95 Leu Glu Thr Leu Lys Ala Leu Leu Glu Val
Asn Lys Gly His Glu Met 100 105 110 Ser Pro Gln Val Ala Thr Leu Ile
Asp Arg Phe Val Lys Gly Arg Gly 115 120 125 Gln Leu Asp Lys Asp Thr
Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly 130 135 140 Tyr Leu Cys Ser
Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser 145 150 155 160 Ser
Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg 165 170
175 Gln Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met
180 185 190 Asn Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly
Gly Ala 195 200 205 Pro Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn
Val Ser Met Asp 210 215 220 Leu Ala Thr Phe Met Lys Leu Arg Thr Asp
Ala Val Leu Pro Leu Thr 225 230 235 240 Val Ala Glu Val Gln Lys Leu
Leu Gly Pro His Val Glu Gly Leu Lys 245 250 255 Ala Glu Glu Arg His
Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg 260 265 270 Gln Asp Asp
Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro 275 280 285 Asn
Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly 290 295
300 Thr Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu
305 310 315 320 Leu Leu Ala Ser Thr Leu Ala 325 371340PRTHomo
sapiens 371Gly Gly Ser Ser Thr Ile Leu Arg Pro Arg Phe Arg Arg Glu
Val Glu 1 5 10 15 Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala Arg Glu
Ile Asp Glu Ser 20 25 30 Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu
Ala Cys Val Asp Ala Ala 35 40 45 Leu Leu Ala Thr Gln Met Asp Arg
Val Asn Ala Ile Pro Phe Thr Tyr 50 55 60 Glu Gln Leu Asp Val Leu
Lys His Lys Leu Asp Glu Leu Tyr Pro Gln 65 70 75 80 Gly Tyr Pro Glu
Ser Val Ile Gln His Leu Gly Tyr Leu Phe Leu Lys 85 90 95 Met Ser
Pro Glu Asp Ile Arg Lys Trp Asn Val Thr Ser Leu Glu Thr 100 105 110
Leu Lys Ala Leu Leu Glu Val Asn Lys Gly His Glu Met Ser Pro Gln 115
120 125 Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln Leu
Asp 130 135 140 Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly
Tyr Leu Cys 145 150 155 160 Ser Leu Ser Pro Glu Glu Leu Ser Ser Val
Pro Pro Ser Ser Ile Trp 165 170 175 Ala Val Arg Pro Gln Asp Leu Asp
Thr Cys Asp Pro Arg Gln Leu Asp 180 185 190 Val Leu Tyr Pro Lys Ala
Arg Leu Ala Phe Gln Asn Met Asn Gly Ser 195 200 205 Glu Tyr Phe Val
Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu 210 215 220 Asp Leu
Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu Ala Thr 225 230 235
240 Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val Ala Glu
245 250 255 Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala
Glu Glu 260 265 270 Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln
Arg Gln Asp Asp 275 280 285 Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly
Gly Ile Pro Asn Gly Tyr 290 295 300 Leu Val Leu Asp Leu Ser Val Gln
Glu Ala Leu Ser Gly Thr Pro Cys 305 310 315 320 Leu Leu Gly Pro Gly
Pro Val Leu Thr Val Leu Ala Leu Leu Leu Ala 325 330 335 Ser Thr Leu
Ala 340
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