U.S. patent application number 15/989532 was filed with the patent office on 2018-09-13 for bispecific egfr/c-met antibodies. The applicant listed for this patent is Janssen Biotech, Inc.. Invention is credited to Mark Chiu, Sheri Moores, Joost Neijssen, Paul Parren, Janine Schuurman.
Application Number | 20180258173 15/989532 |
Document ID | / |
Family ID | 59896349 |
Filed Date | 2018-09-13 |
United States Patent Application | 20180258173 |
Kind Code | A1 |
Chiu; Mark ; et al. | September 13, 2018 |
Bispecific EGFR/c-Met antibodies and methods of making and using the molecules.
Inventors: | Chiu; Mark; (Paoli, PA) ; Moores; Sheri; (Phoenixville, PA) ; Neijssen; Joost; (Ultrecht, NL) ; Parren; Paul; (Ultrecht, NL) ; Schuurman; Janine; (Ultrecht, NL) | ||||||||||
Applicant: |
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Family ID: | 59896349 | ||||||||||
Appl. No.: | 15/989532 | ||||||||||
Filed: | May 25, 2018 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
15616016 | Jun 7, 2017 | |||
15989532 | ||||
15386195 | Dec 21, 2016 | 9695242 | ||
15616016 | ||||
14283257 | May 21, 2014 | 9580508 | ||
15386195 | ||||
14086588 | Nov 21, 2013 | 9593164 | ||
14283257 | ||||
61728912 | Nov 21, 2012 | |||
61782550 | Mar 14, 2013 | |||
61809541 | Apr 8, 2013 | |||
61864717 | Aug 12, 2013 | |||
61892797 | Oct 18, 2013 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | A61K 39/395 20130101; A61K 31/4545 20130101; C07K 2317/76 20130101; A61K 2300/00 20130101; A61K 31/437 20130101; C07K 2318/20 20130101; A61K 33/24 20130101; A61K 31/517 20130101; A61K 2039/505 20130101; C07K 16/2863 20130101; C07K 2317/31 20130101; A61K 39/3955 20130101; A61K 31/5377 20130101; C07K 2317/73 20130101; A61K 45/06 20130101; A61K 39/395 20130101; A61K 2300/00 20130101; A61K 31/4545 20130101; A61K 2300/00 20130101; A61K 31/517 20130101; A61K 2300/00 20130101; A61K 33/24 20130101; A61K 2300/00 20130101 |
International Class: | C07K 16/28 20060101 C07K016/28; A61K 45/06 20060101 A61K045/06; A61K 31/4545 20060101 A61K031/4545; A61K 31/517 20060101 A61K031/517; A61K 31/5377 20060101 A61K031/5377; A61K 33/24 20060101 A61K033/24; A61K 39/395 20060101 A61K039/395; A61K 31/437 20060101 A61K031/437 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 240 <210> SEQ ID NO 1 <211> LENGTH: 89 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Tencon FN3 scaffold
<400> SEQUENCE: 1 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu
Val Thr Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Thr Ala Pro Asp
Ala Ala Phe Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu
Lys Val Gly Glu Ala Ile Asn Leu Thr 35 40 45 Val Pro Gly Ser Glu
Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr
Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 65 70 75 80 Asn
Pro Leu Ser Ala Glu Phe Thr Thr 85 <210> SEQ ID NO 2
<211> LENGTH: 58 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: primer <400> SEQUENCE: 2 ggaaacagga tctaccatgc
tgccggcgcc gaaaaacctg gttgtttctg aagttacc 58 <210> SEQ ID NO
3 <211> LENGTH: 21 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: primer <400> SEQUENCE: 3 aacaccgtag
atagaaacgg t 21 <210> SEQ ID NO 4 <211> LENGTH: 131
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: primer
<400> SEQUENCE: 4 cggcggttag aacgcggcta caattaatac ataaccccat
ccccctgttg acaattaatc 60 atcggctcgt ataatgtgtg gaattgtgag
cggataacaa tttcacacag gaaacaggat 120 ctaccatgct g 131 <210>
SEQ ID NO 5 <211> LENGTH: 21 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: primer <400> SEQUENCE: 5
cggcggttag aacgcggcta c 21 <210> SEQ ID NO 6 <211>
LENGTH: 66 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: primer
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (26)..(27) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (29)..(30) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (32)..(33) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (35)..(36) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (38)..(39)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(41)..(42) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (44)..(45) <223> OTHER INFORMATION: n is a, c, g,
or t <400> SEQUENCE: 6 ggtggtgaat tccgcagaca gcggsnnsnn
snnsnnsnns nnsnnaacac cgtagataga 60 aacggt 66 <210> SEQ ID NO
7 <211> LENGTH: 69 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: primer <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (26)..(27) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (29)..(30)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(32)..(33) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (35)..(36) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (38)..(39) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (41)..(42) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (44)..(45) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (47)..(48)
<223> OTHER INFORMATION: n is a, c, g, or t <400>
SEQUENCE: 7 ggtggtgaat tccgcagaca gcggsnnsnn snnsnnsnns nnsnnsnnaa
caccgtagat 60 agaaacggt 69 <210> SEQ ID NO 8 <211>
LENGTH: 72 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: primer
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (26)..(27) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (29)..(30) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (32)..(33) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (35)..(36) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (38)..(39)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(41)..(42) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (44)..(45) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (47)..(48) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (50)..(51) <223> OTHER
INFORMATION: n is a, c, g, or t <400> SEQUENCE: 8 ggtggtgaat
tccgcagaca gcggsnnsnn snnsnnsnns nnsnnsnnsn naacaccgta 60
gatagaaacg gt 72 <210> SEQ ID NO 9 <211> LENGTH: 75
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: primer
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (26)..(27) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (29)..(30) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (32)..(33) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (35)..(36) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (38)..(39)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(41)..(42) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (44)..(45) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (47)..(48) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (50)..(51) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (53)..(54) <223>
OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 9
ggtggtgaat tccgcagaca gcggsnnsnn snnsnnsnns nnsnnsnnsn nsnnaacacc
60 gtagatagaa acggt 75 <210> SEQ ID NO 10 <211> LENGTH:
80 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: primer
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (28)..(29) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (31)..(32) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (34)..(35) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (37)..(38) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (40)..(41)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(43)..(44) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (46)..(47) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (49)..(50) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (52)..(53) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (55)..(56) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (58)..(59)
<223> OTHER INFORMATION: n is a, c, g, or t <400>
SEQUENCE: 10 rmggtggtga attccgcaga cagcggsnns nnsnnsnnsn nsnnsnnsnn
snnsnnsnna 60 acaccgtaga tagaaacggt 80 <210> SEQ ID NO 11
<211> LENGTH: 81 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: primer <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (26)..(27) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (29)..(30) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (32)..(33)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(35)..(36) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (38)..(39) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (41)..(42) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (44)..(45) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (47)..(48) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (50)..(51)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(53)..(54) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (56)..(57) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (59)..(60) <223> OTHER INFORMATION: n
is a, c, g, or t <400> SEQUENCE: 11 ggtggtgaat tccgcagaca
gcggsnnsnn snnsnnsnns nnsnnsnnsn nsnnsnnsnn 60 aacaccgtag
atagaaacgg t 81 <210> SEQ ID NO 12 <211> LENGTH: 81
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: primer
<400> SEQUENCE: 12 aagatcagtt gcggccgcta gactagaacc
gctgccatgg tgatggtgat ggtgaccgcc 60 ggtggtgaat tccgcagaca g 81
<210> SEQ ID NO 13 <211> LENGTH: 30 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: primer <400> SEQUENCE: 13
cggcggttag aacgcggcta caattaatac 30 <210> SEQ ID NO 14
<211> LENGTH: 22 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: primer <400> SEQUENCE: 14 catgattacg ccaagctcag
aa 22 <210> SEQ ID NO 15 <211> LENGTH: 65 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: primer <400>
SEQUENCE: 15 gagccgccgc caccggttta atggtgatgg tgatggtgac caccggtggt
gaattccgca 60 gacag 65 <210> SEQ ID NO 16 <211> LENGTH:
37 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: primer
<400> SEQUENCE: 16 aagaaggaga accggtatgc tgccggcgcc gaaaaac
37 <210> SEQ ID NO 17 <211> LENGTH: 89 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: primer <400>
SEQUENCE: 17 tttgggaagc ttctaggtct cggcggtcac catcaccatc accatggcag
cggttctagt 60 ctagcggccc caactgatct tcaccaaac 89 <210> SEQ ID
NO 18 <211> LENGTH: 94 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 18
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5
10 15 Leu Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe
Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Asn Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Glu Phe Thr Thr 85 90 <210> SEQ ID NO 19
<211> LENGTH: 94 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 19 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5 10
15 Leu Arg Leu Ser Trp Thr Tyr Asp Arg Asp Gly Tyr Asp Ser Phe Leu
20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val
His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met Arg Gly Leu Pro Leu
Ser Ala Glu Phe Thr Thr 85 90 <210> SEQ ID NO 20 <211>
LENGTH: 94 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: EGFR
binding FN3 domain <400> SEQUENCE: 20 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser
Trp Gly Tyr Asn Gly Asp His Phe Asp Ser Phe Leu 20 25 30 Ile Gln
Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys
Asp 65 70 75 80 Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr
Thr 85 90 <210> SEQ ID NO 21 <211> LENGTH: 94
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: EGFR binding
FN3 domain <400> SEQUENCE: 21 Leu Pro Ala Pro Lys Asn Leu Val
Val Ser Glu Val Thr Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Asp
Asp Pro Arg Gly Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln
Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 35 40 45 Val Pro
Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60
Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65
70 75 80 Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85
90 <210> SEQ ID NO 22 <211> LENGTH: 94 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 22 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Thr Trp Pro
Tyr Ala Asp Leu Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90
<210> SEQ ID NO 23 <211> LENGTH: 94 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 23 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Gly Tyr Asn Gly Asp His
Phe Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Asn Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90 <210> SEQ
ID NO 24 <211> LENGTH: 95 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 24
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5
10 15 Leu Arg Leu Ser Trp Asp Tyr Asp Leu Gly Val Tyr Phe Asp Ser
Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala
Ile Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu
Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr
Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu
Pro Leu Ser Ala Glu Phe Thr Thr 85 90 95 <210> SEQ ID NO 25
<211> LENGTH: 94 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 25 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5 10
15 Leu Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe Leu
20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val
His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met Arg Gly Leu Pro Leu
Ser Ala Glu Phe Thr Thr 85 90 <210> SEQ ID NO 26 <211>
LENGTH: 94 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: EGFR
binding FN3 domain <400> SEQUENCE: 26 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 20 25 30 Ile Gln
Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Gly Ser Tyr Val
Phe 65 70 75 80 Glu His Asp Val Met Leu Pro Leu Ser Ala Glu Phe Thr
Thr 85 90 <210> SEQ ID NO 27 <211> LENGTH: 94
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: EGFR binding
FN3 domain <400> SEQUENCE: 27 Leu Pro Ala Pro Lys Asn Leu Val
Val Ser Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp
Asp Pro Trp Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln
Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro
Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60
Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65
70 75 80 Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr 85
90 <210> SEQ ID NO 28 <211> LENGTH: 94 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 28 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val Leu Gly Ser Tyr Val Phe 65 70 75 80
Glu His Asp Val Met Leu Pro Leu Ser Ala Ile Phe Thr Thr 85 90
<210> SEQ ID NO 29 <211> LENGTH: 94 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 29 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Thr Trp Pro Tyr Ala Asp
Leu Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Asn Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90 <210> SEQ
ID NO 30 <211> LENGTH: 37 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: primer <400> SEQUENCE: 30 Ala Ala Gly Ala
Ala Gly Gly Ala Gly Ala Ala Cys Cys Gly Gly Thr 1 5 10 15 Ala Thr
Gly Cys Thr Gly Cys Cys Gly Gly Cys Gly Cys Cys Gly Ala 20 25 30
Ala Ala Ala Ala Cys 35 <210> SEQ ID NO 31 <211> LENGTH:
65 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: primer
<400> SEQUENCE: 31 Gly Ala Gly Cys Cys Gly Cys Cys Gly Cys
Cys Ala Cys Cys Gly Gly 1 5 10 15 Thr Thr Thr Ala Ala Thr Gly Gly
Thr Gly Ala Thr Gly Gly Thr Gly 20 25 30 Ala Thr Gly Gly Thr Gly
Ala Cys Cys Ala Cys Cys Gly Gly Thr Gly 35 40 45 Gly Thr Gly Ala
Ala Gly Ala Thr Cys Gly Cys Ala Gly Ala Cys Ala 50 55 60 Gly 65
<210> SEQ ID NO 32 <211> LENGTH: 89 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain <400>
SEQUENCE: 32 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Asp Glu Val Val Val Gly
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Tyr Val
Asn Ile Leu Gly Val Lys Gly Gly Ser Ile Ser 65 70 75 80 Val Pro Leu
Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 33 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: c-Met
binding FN3 domain <400> SEQUENCE: 33 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Phe 20 25 30 Ile Arg
Tyr Asp Glu Phe Leu Arg Ser Gly Glu Ala Ile Val Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Trp Val Thr Ile Leu Gly Val Lys Gly Gly Leu Val
Ser 65 70 75 80 Thr Pro Leu Ser Ala Ile Phe Thr Thr 85 <210>
SEQ ID NO 34 <211> LENGTH: 89 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain <400>
SEQUENCE: 34 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Ile Val
Asn Ile Met Gly Val Lys Gly Gly Ser Ile Ser 65 70 75 80 His Pro Leu
Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 35 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: c-Met
binding FN3 domain <400> SEQUENCE: 35 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile Val Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Val Val Asn Ile Leu Gly Val Lys Gly Gly Gly Leu
Ser 65 70 75 80 Val Pro Leu Ser Ala Ile Phe Thr Thr 85 <210>
SEQ ID NO 36 <211> LENGTH: 89 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain <400>
SEQUENCE: 36 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Val 20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val
Gln Ile Leu Gly Val Lys Gly Gly Tyr Ile Ser 65 70 75 80 Ile Pro Leu
Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 37 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: c-Met
binding FN3 domain <400> SEQUENCE: 37 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg
Tyr Leu Glu Phe Leu Leu Gly Gly Glu Ala Ile Val Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Val Val Gln Ile Met Gly Val Lys Gly Gly Thr Val
Ser 65 70 75 80 Pro Pro Leu Ser Ala Ile Phe Thr Thr 85 <210>
SEQ ID NO 38 <211> LENGTH: 89 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain <400>
SEQUENCE: 38 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val
Gly Ile Asn Gly Val Lys Gly Gly Tyr Ile Ser 65 70 75 80 Tyr Pro Leu
Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 39 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: c-Met
binding FN3 domain <400> SEQUENCE: 39 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile Val Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Asp Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Gly Val Thr Ile Asn Gly Val Lys Gly Gly Arg Val
Ser 65 70 75 80 Thr Pro Leu Ser Ala Ile Phe Thr Thr 85 <210>
SEQ ID NO 40 <211> LENGTH: 89 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain <400>
SEQUENCE: 40 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val
Gln Ile Ile Gly Val Lys Gly Gly His Ile Ser 65 70 75 80 Leu Pro Leu
Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 41 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: c-Met
binding FN3 domain <400> SEQUENCE: 41 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile Val Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Val Val Asn Ile Met Gly Val Lys Gly Gly Lys Ile
Ser 65 70 75 80 Pro Pro Leu Ser Ala Ile Phe Thr Thr 85 <210>
SEQ ID NO 42 <211> LENGTH: 89 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain <400>
SEQUENCE: 42 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Ala Val
Asn Ile Met Gly Val Lys Gly Gly Arg Val Ser 65 70 75 80 Val Pro Leu
Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 43 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: c-Met
binding FN3 domain <400> SEQUENCE: 43 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile Val Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Val Val Gln Ile Leu Gly Val Lys Gly Gly Ser Ile
Ser 65 70 75 80 Val Pro Leu Ser Ala Ile Phe Thr Thr 85 <210>
SEQ ID NO 44 <211> LENGTH: 89 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain <400>
SEQUENCE: 44 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val
Asn Ile Met Gly Val Lys Gly Gly Ser Ile Ser 65 70 75 80 Tyr Pro Leu
Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 45 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: c-Met
binding FN3 domain <400> SEQUENCE: 45 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile Val Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Val Val Gln Ile Leu Gly Val Lys Gly Gly Tyr Ile
Ser 65 70 75 80 Ile Pro Leu Ser Ala Ile Phe Thr Thr 85 <210>
SEQ ID NO 46 <211> LENGTH: 89 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain <400>
SEQUENCE: 46 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val
Gln Ile Met Gly Val Lys Gly Gly Thr Val Ser 65 70 75 80 Pro Pro Leu
Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 47 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: c-Met
binding FN3 domain <400> SEQUENCE: 47 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg
Tyr Phe Glu Phe Thr Thr Ala Gly Glu Ala Ile Val Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Val Val Asn Ile Met Gly Val Lys Gly Gly Ser Ile
Ser 65 70 75 80 Pro Pro Leu Ser Ala Ile Phe Thr Thr 85 <210>
SEQ ID NO 48 <211> LENGTH: 89 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain <400>
SEQUENCE: 48 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Leu Leu Ser Thr
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val
Asn Ile Met Gly Val Lys Gly Gly Ser Ile Ser 65 70 75 80 Pro Pro Leu
Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 49 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: c-Met
binding FN3 domain <400> SEQUENCE: 49 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg
Tyr Phe Glu Phe Val Ser Lys Gly Glu Ala Ile Val Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Val Val Asn Ile Met Gly Val Lys Gly Gly Ser Ile
Ser 65 70 75 80 Pro Pro Leu Ser Ala Ile Phe Thr Thr 85 <210>
SEQ ID NO 50 <211> LENGTH: 205 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 50 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 100 105 110 Gly Gly Ser Met Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val 115 120 125 Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe 130 135 140 Asp Ser Phe Trp Ile Arg
Tyr Asp Glu Val Val Val Gly Gly Glu Ala 145 150 155 160 Ile Val Leu
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 165 170 175 Leu
Lys Pro Gly Thr Glu Tyr Tyr Val Asn Ile Leu Gly Val Lys Gly 180 185
190 Gly Ser Ile Ser Val Pro Leu Ser Ala Ile Phe Thr Thr 195 200 205
<210> SEQ ID NO 51 <211> LENGTH: 204 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 51 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 100 105 110 Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Arg Val Thr 115 120 125 Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro Asp Ala Ala Phe Asp 130 135 140 Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile 145 150 155 160 Val Leu Thr
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 165 170 175 Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Met Gly Val Lys Gly Gly 180 185
190 Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr Thr 195 200
<210> SEQ ID NO 52 <211> LENGTH: 205 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 52 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 100 105 110 Gly Gly Ser Met Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val 115 120 125 Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe 130 135 140 Asp Ser Phe Trp Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala 145 150 155 160 Ile Val Leu
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 165 170 175 Leu
Lys Pro Gly Thr Glu Tyr Val Val Gln Ile Ile Gly Val Lys Gly 180 185
190 Gly His Ile Ser Leu Pro Leu Ser Ala Ile Phe Thr Thr 195 200 205
<210> SEQ ID NO 53 <211> LENGTH: 205 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 53 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 100 105 110 Gly Gly Ser Met Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val 115 120 125 Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe 130 135 140 Asp Ser Phe Phe Ile Arg
Tyr Asp Glu Phe Leu Arg Ser Gly Glu Ala 145 150 155 160 Ile Val Leu
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 165 170 175 Leu
Lys Pro Gly Thr Glu Tyr Trp Val Thr Ile Leu Gly Val Lys Gly 180 185
190 Gly Leu Val Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 195 200 205
<210> SEQ ID NO 54 <211> LENGTH: 205 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 54 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Ala Asp Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 100 105 110 Gly Gly Ser Met Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val 115 120 125 Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe 130 135 140 Asp Ser Phe Trp Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala 145 150 155 160 Ile Val Leu
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 165 170 175 Leu
Lys Pro Gly Thr Glu Tyr Val Val Asn Ile Met Gly Val Lys Gly 180 185
190 Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr Thr 195 200 205
<210> SEQ ID NO 55 <211> LENGTH: 205 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 55 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Ala Asp Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 100 105 110 Gly Gly Ser Met Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val 115 120 125 Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe 130 135 140 Asp Ser Phe Trp Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala 145 150 155 160 Ile Val Leu
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 165 170 175 Leu
Lys Pro Gly Thr Glu Tyr Val Val Gln Ile Ile Gly Val Lys Gly 180 185
190 Gly His Ile Ser Leu Pro Leu Ser Ala Ile Phe Thr Thr 195 200 205
<210> SEQ ID NO 56 <211> LENGTH: 205 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 56 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Ala Asp Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 100 105 110 Gly Gly Ser Met Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val 115 120 125 Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe 130 135 140 Asp Ser Phe Trp Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala 145 150 155 160 Ile Val Leu
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 165 170 175 Leu
Lys Pro Gly Thr Glu Tyr Val Val Gln Ile Ile Gly Val Lys Gly 180 185
190 Gly His Ile Ser Leu Pro Leu Ser Ala Ile Phe Thr Thr 195 200 205
<210> SEQ ID NO 57 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 57 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Met
Gly Val Lys Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr <210> SEQ ID NO 58 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: bispecific
EGFR/cMet binding molecule <400> SEQUENCE: 58 Met Leu Pro Ala
Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala
Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30
Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35
40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys
Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn
Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala
Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro
Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu
Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe
Asp Ser Phe Trp Ile Arg Tyr Asp Glu Val Val 130 135 140 Val Gly Gly
Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160
Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Tyr Val Asn Ile 165
170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Val Pro Leu Ser Ala Ile
Phe 180 185 190 Thr Thr <210> SEQ ID NO 59 <211>
LENGTH: 195 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
bispecific EGFR/cMet binding molecule <400> SEQUENCE: 59 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala
Pro Ala Pro Met Leu Pro Ala Pro Lys Asn 100 105 110 Leu Val Val Ser
Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr 115 120 125 Ala Pro
Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe 130 135 140
Leu Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg 145
150 155 160 Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val
Val Asn 165 170 175 Ile Met Gly Val Lys Gly Gly Lys Ile Ser Pro Pro
Leu Ser Ala Ile 180 185 190 Phe Thr Thr 195 <210> SEQ ID NO
60 <211> LENGTH: 194 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: bispecific EGFR/cMet binding molecule
<400> SEQUENCE: 60 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Ala Asp
Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu
Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr
Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80
Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85
90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn
Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg
Tyr Asp Glu Val Val 130 135 140 Val Gly Gly Glu Ala Ile Val Leu Thr
Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu
Lys Pro Gly Thr Glu Tyr Tyr Val Asn Ile 165 170 175 Leu Gly Val Lys
Gly Gly Ser Ile Ser Val Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr
<210> SEQ ID NO 61 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 61 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu
Gly Val Lys Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr <210> SEQ ID NO 62 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: bispecific
EGFR/cMet binding molecule <400> SEQUENCE: 62 Met Leu Pro Ala
Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala
Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30
Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35
40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys
Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn
Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala
Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro
Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu
Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe
Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140 Gly Ser Gly
Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160
Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165
170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile
Phe 180 185 190 Thr Thr <210> SEQ ID NO 63 <211>
LENGTH: 194 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
bispecific EGFR/cMet binding molecule <400> SEQUENCE: 63 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro
Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala
Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg
Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp
Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140
Ser Lys Gly Asp Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145
150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val
Asn Ile 165 170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu
Ser Ala Ile Phe 180 185 190 Thr Thr <210> SEQ ID NO 64
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: bispecific EGFR/cMet binding molecule <400>
SEQUENCE: 64 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu
Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Ser Val Lys Gly Gly Ser
Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr <210>
SEQ ID NO 65 <211> LENGTH: 194 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 65 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro His Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu
Gly Val Lys Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr <210> SEQ ID NO 66 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: bispecific
EGFR/cMet binding molecule <400> SEQUENCE: 66 Met Leu Pro Ala
Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala
Arg Leu Ser Trp Asp Asp Pro His Ala Phe Tyr Glu Ser Phe 20 25 30
Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35
40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys
Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn
Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala
Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro
Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu
Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe
Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140 Gly Ser Gly
Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160
Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165
170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile
Phe 180 185 190 Thr Thr <210> SEQ ID NO 67 <211>
LENGTH: 194 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
bispecific EGFR/cMet binding molecule <400> SEQUENCE: 67 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Ala Arg Leu Ser Trp Asp Asp Pro His Ala Phe Tyr Glu Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro
Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala
Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg
Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp
Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140
Ser Lys Gly Asp Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145
150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val
Asn Ile 165 170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu
Ser Ala Ile Phe 180 185 190 Thr Thr <210> SEQ ID NO 68
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: bispecific EGFR/cMet binding molecule <400>
SEQUENCE: 68 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro His Ala
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu
Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Ser Val Lys Gly Gly Ser
Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr <210>
SEQ ID NO 69 <211> LENGTH: 194 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 69 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Ala Asp Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu
Gly Val Lys Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr <210> SEQ ID NO 70 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: bispecific
EGFR/cMet binding molecule <400> SEQUENCE: 70 Met Leu Pro Ala
Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala
Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe 20 25 30
Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35
40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys
Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn
Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala
Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro
Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu
Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe
Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140 Gly Ser Gly
Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160
Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165
170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile
Phe 180 185 190 Thr Thr <210> SEQ ID NO 71 <211>
LENGTH: 194 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
bispecific EGFR/cMet binding molecule <400> SEQUENCE: 71 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro
Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala
Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg
Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp
Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140
Ser Lys Gly Asp Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145
150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val
Asn Ile 165 170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu
Ser Ala Ile Phe 180 185 190 Thr Thr <210> SEQ ID NO 72
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: bispecific EGFR/cMet binding molecule <400>
SEQUENCE: 72 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Ala Asp Pro His Gly
Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu
Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Ser Val Lys Gly Gly Ser
Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr <210>
SEQ ID NO 73 <211> LENGTH: 1210 <212> TYPE: PRT
<213> ORGANISM: HOMO SAPIENS <400> SEQUENCE: 73 Met Arg
Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 1 5 10 15
Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 20
25 30 Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His
Phe 35 40 45 Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val
Leu Gly Asn 50 55 60 Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp
Leu Ser Phe Leu Lys 65 70 75 80 Thr Ile Gln Glu Val Ala Gly Tyr Val
Leu Ile Ala Leu Asn Thr Val 85 90 95 Glu Arg Ile Pro Leu Glu Asn
Leu Gln Ile Ile Arg Gly Asn Met Tyr 100 105 110 Tyr Glu Asn Ser Tyr
Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 115 120 125 Lys Thr Gly
Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 130 135 140 His
Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 145 150
155 160 Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn
Met 165 170 175 Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys
Cys Asp Pro 180 185 190 Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly
Glu Glu Asn Cys Gln 195 200 205 Lys Leu Thr Lys Ile Ile Cys Ala Gln
Gln Cys Ser Gly Arg Cys Arg 210 215 220 Gly Lys Ser Pro Ser Asp Cys
Cys His Asn Gln Cys Ala Ala Gly Cys 225 230 235 240 Thr Gly Pro Arg
Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 245 250 255 Glu Ala
Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 260 265 270
Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 275
280 285 Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp
His 290 295 300 Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu
Met Glu Glu 305 310 315 320 Asp Gly Val Arg Lys Cys Lys Lys Cys Glu
Gly Pro Cys Arg Lys Val 325 330 335 Cys Asn Gly Ile Gly Ile Gly Glu
Phe Lys Asp Ser Leu Ser Ile Asn 340 345 350 Ala Thr Asn Ile Lys His
Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 355 360 365 Leu His Ile Leu
Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 370 375 380 Pro Pro
Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 385 390 395
400 Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp
405 410 415 Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr
Lys Gln 420 425 430 His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn
Ile Thr Ser Leu 435 440 445 Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp
Gly Asp Val Ile Ile Ser 450 455 460 Gly Asn Lys Asn Leu Cys Tyr Ala
Asn Thr Ile Asn Trp Lys Lys Leu 465 470 475 480 Phe Gly Thr Ser Gly
Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 485 490 495 Asn Ser Cys
Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 500 505 510 Glu
Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 515 520
525 Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly
530 535 540 Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys
His Pro 545 550 555 560 Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys
Thr Gly Arg Gly Pro 565 570 575 Asp Asn Cys Ile Gln Cys Ala His Tyr
Ile Asp Gly Pro His Cys Val 580 585 590 Lys Thr Cys Pro Ala Gly Val
Met Gly Glu Asn Asn Thr Leu Val Trp 595 600 605 Lys Tyr Ala Asp Ala
Gly His Val Cys His Leu Cys His Pro Asn Cys 610 615 620 Thr Tyr Gly
Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 625 630 635 640
Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 645
650 655 Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg
His 660 665 670 Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu
Arg Glu Leu 675 680 685 Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro
Asn Gln Ala Leu Leu 690 695 700 Arg Ile Leu Lys Glu Thr Glu Phe Lys
Lys Ile Lys Val Leu Gly Ser 705 710 715 720 Gly Ala Phe Gly Thr Val
Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 725 730 735 Lys Val Lys Ile
Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 740 745 750 Pro Lys
Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 755 760 765
Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 770
775 780 Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu
Asp 785 790 795 800 Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln
Tyr Leu Leu Asn 805 810 815 Trp Cys Val Gln Ile Ala Lys Gly Met Asn
Tyr Leu Glu Asp Arg Arg 820 825 830 Leu Val His Arg Asp Leu Ala Ala
Arg Asn Val Leu Val Lys Thr Pro 835 840 845 Gln His Val Lys Ile Thr
Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 850 855 860 Glu Glu Lys Glu
Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 865 870 875 880 Met
Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 885 890
895 Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser
900 905 910 Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile
Leu Glu 915 920 925 Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr
Ile Asp Val Tyr 930 935 940 Met Ile Met Val Lys Cys Trp Met Ile Asp
Ala Asp Ser Arg Pro Lys 945 950 955 960 Phe Arg Glu Leu Ile Ile Glu
Phe Ser Lys Met Ala Arg Asp Pro Gln 965 970 975 Arg Tyr Leu Val Ile
Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 980 985 990 Thr Asp Ser
Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp 995 1000 1005
Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe 1010
1015 1020 Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser
Leu 1025 1030 1035 Ser Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile
Asp Arg Asn 1040 1045 1050 Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp
Ser Phe Leu Gln Arg 1055 1060 1065 Tyr Ser Ser Asp Pro Thr Gly Ala
Leu Thr Glu Asp Ser Ile Asp 1070 1075 1080 Asp Thr Phe Leu Pro Val
Pro Glu Tyr Ile Asn Gln Ser Val Pro 1085 1090 1095 Lys Arg Pro Ala
Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln 1100 1105 1110 Pro Leu
Asn Pro Ala Pro Ser Arg Asp Pro His Tyr Gln Asp Pro 1115 1120 1125
His Ser Thr Ala Val Gly Asn Pro Glu Tyr Leu Asn Thr Val Gln 1130
1135 1140 Pro Thr Cys Val Asn Ser Thr Phe Asp Ser Pro Ala His Trp
Ala 1145 1150 1155 Gln Lys Gly Ser His Gln Ile Ser Leu Asp Asn Pro
Asp Tyr Gln 1160 1165 1170 Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro
Asn Gly Ile Phe Lys 1175 1180 1185 Gly Ser Thr Ala Glu Asn Ala Glu
Tyr Leu Arg Val Ala Pro Gln 1190 1195 1200 Ser Ser Glu Phe Ile Gly
Ala 1205 1210 <210> SEQ ID NO 74 <211> LENGTH: 53
<212> TYPE: PRT <213> ORGANISM: HOMO SAPIENS
<400> SEQUENCE: 74 Asn Ser Asp Ser Glu Cys Pro Leu Ser His
Asp Gly Tyr Cys Leu His 1 5 10 15 Asp Gly Val Cys Met Tyr Ile Glu
Ala Leu Asp Lys Tyr Ala Cys Asn 20 25 30 Cys Val Val Gly Tyr Ile
Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 35 40 45 Trp Trp Glu Leu
Arg 50 <210> SEQ ID NO 75 <211> LENGTH: 2201
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 75 Met Gly Ala Met Thr Gln Leu Leu Ala Gly
Val Phe Leu Ala Phe Leu 1 5 10 15 Ala Leu Ala Thr Glu Gly Gly Val
Leu Lys Lys Val Ile Arg His Lys 20 25 30 Arg Gln Ser Gly Val Asn
Ala Thr Leu Pro Glu Glu Asn Gln Pro Val 35 40 45 Val Phe Asn His
Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys 50 55 60 Ser Val
Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro 65 70 75 80
Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 85
90 95 Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys
Gly 100 105 110 Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg
Leu Glu Glu 115 120 125 Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln
Cys Thr Ala Gly Ala 130 135 140 Gly Cys Cys Leu Gln Pro Ala Thr Gly
Arg Leu Asp Thr Arg Pro Phe 145 150 155 160 Cys Ser Gly Arg Gly Asn
Phe Ser Thr Glu Gly Cys Gly Cys Val Cys 165 170 175 Glu Pro Gly Trp
Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly 180 185 190 Asn Cys
His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp 195 200 205
Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp 210
215 220 Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe
Glu 225 230 235 240 Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys
Pro Val Pro Cys 245 250 255 Ser Glu Glu His Gly Thr Cys Val Asp Gly
Leu Cys Val Cys His Asp 260 265 270 Gly Phe Ala Gly Asp Asp Cys Asn
Lys Pro Leu Cys Leu Asn Asn Cys 275 280 285 Tyr Asn Arg Gly Arg Cys
Val Glu Asn Glu Cys Val Cys Asp Glu Gly 290 295 300 Phe Thr Gly Glu
Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 305 310 315 320 Asp
Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 325 330
335 Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr
340 345 350 Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly
Phe Ala 355 360 365 Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp
Cys His Asn Arg 370 375 380 Gly Arg Cys Val Asp Gly Arg Cys Glu Cys
Asp Asp Gly Phe Thr Gly 385 390 395 400 Ala Asp Cys Gly Glu Leu Lys
Cys Pro Asn Gly Cys Ser Gly His Gly 405 410 415 Arg Cys Val Asn Gly
Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 420 425 430 Asp Cys Ser
Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg 435 440 445 Cys
Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp 450 455
460 Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys
465 470 475 480 Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly
Glu Asp Cys 485 490 495 Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn
Arg Gly Leu Cys Val 500 505 510 Asp Gly Gln Cys Val Cys Glu Asp Gly
Phe Thr Gly Pro Asp Cys Ala 515 520 525 Glu Leu Ser Cys Pro Asn Asp
Cys His Gly Gln Gly Arg Cys Val Asn 530 535 540 Gly Gln Cys Val Cys
His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu 545 550 555 560 Gln Arg
Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly 565 570 575
Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His 580
585 590 Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly
Arg 595 600 605 Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser
Glu Val Ser 610 615 620 Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr
Glu Glu Thr Val Asn 625 630 635 640 Leu Ala Trp Asp Asn Glu Met Arg
Val Thr Glu Tyr Leu Val Val Tyr 645 650 655 Thr Pro Thr His Glu Gly
Gly Leu Glu Met Gln Phe Arg Val Pro Gly 660 665 670 Asp Gln Thr Ser
Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 675 680 685 Phe Ile
Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 690 695 700
Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe 705
710 715 720 Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro
Leu Asp 725 730 735 Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn
Met Asn Lys Glu 740 745 750 Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg
Arg Pro Glu Thr Ser Tyr 755 760 765 Arg Gln Thr Gly Leu Ala Pro Gly
Gln Glu Tyr Glu Ile Ser Leu His 770 775 780 Ile Val Lys Asn Asn Thr
Arg Gly Pro Gly Leu Lys Arg Val Thr Thr 785 790 795 800 Thr Arg Leu
Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp 805 810 815 Thr
Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly 820 825
830 Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr
835 840 845 Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn
Leu Lys 850 855 860 Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg
Arg Gly Asp Met 865 870 875 880 Ser Ser Asn Pro Ala Lys Glu Thr Phe
Thr Thr Gly Leu Asp Ala Pro 885 890 895 Arg Asn Leu Arg Arg Val Ser
Gln Thr Asp Asn Ser Ile Thr Leu Glu 900 905 910 Trp Arg Asn Gly Lys
Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 915 920 925 Pro Ile Ser
Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln 930 935 940 Gln
Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 945 950
955 960 Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn
Pro 965 970 975 Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys
Asp Leu Gln 980 985 990 Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu
Leu Trp Lys Thr Pro 995 1000 1005 Leu Ala Lys Phe Asp Arg Tyr Arg
Leu Asn Tyr Ser Leu Pro Thr 1010 1015 1020 Gly Gln Trp Val Gly Val
Gln Leu Pro Arg Asn Thr Thr Ser Tyr 1025 1030 1035 Val Leu Arg Gly
Leu Glu Pro Gly Gln Glu Tyr Asn Val Leu Leu 1040 1045 1050 Thr Ala
Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val Lys 1055 1060 1065
Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr 1070
1075 1080 Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala
Asp 1085 1090 1095 Gln Ala Tyr Glu His Phe Ile Ile Gln Val Gln Glu
Ala Asn Lys 1100 1105 1110 Val Glu Ala Ala Arg Asn Leu Thr Val Pro
Gly Ser Leu Arg Ala 1115 1120 1125 Val Asp Ile Pro Gly Leu Lys Ala
Ala Thr Pro Tyr Thr Val Ser 1130 1135 1140 Ile Tyr Gly Val Ile Gln
Gly Tyr Arg Thr Pro Val Leu Ser Ala 1145 1150 1155 Glu Ala Ser Thr
Gly Glu Thr Pro Asn Leu Gly Glu Val Val Val 1160 1165 1170 Ala Glu
Val Gly Trp Asp Ala Leu Lys Leu Asn Trp Thr Ala Pro 1175 1180 1185
Glu Gly Ala Tyr Glu Tyr Phe Phe Ile Gln Val Gln Glu Ala Asp 1190
1195 1200 Thr Val Glu Ala Ala Gln Asn Leu Thr Val Pro Gly Gly Leu
Arg 1205 1210 1215 Ser Thr Asp Leu Pro Gly Leu Lys Ala Ala Thr His
Tyr Thr Ile 1220 1225 1230 Thr Ile Arg Gly Val Thr Gln Asp Phe Ser
Thr Thr Pro Leu Ser 1235 1240 1245 Val Glu Val Leu Thr Glu Glu Val
Pro Asp Met Gly Asn Leu Thr 1250 1255 1260 Val Thr Glu Val Ser Trp
Asp Ala Leu Arg Leu Asn Trp Thr Thr 1265 1270 1275 Pro Asp Gly Thr
Tyr Asp Gln Phe Thr Ile Gln Val Gln Glu Ala 1280 1285 1290 Asp Gln
Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser Leu 1295 1300 1305
Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr 1310
1315 1320 Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro
Leu 1325 1330 1335 Ala Val Glu Val Val Thr Glu Asp Leu Pro Gln Leu
Gly Asp Leu 1340 1345 1350 Ala Val Ser Glu Val Gly Trp Asp Gly Leu
Arg Leu Asn Trp Thr 1355 1360 1365 Ala Ala Asp Asn Ala Tyr Glu His
Phe Val Ile Gln Val Gln Glu 1370 1375 1380 Val Asn Lys Val Glu Ala
Ala Gln Asn Leu Thr Leu Pro Gly Ser 1385 1390 1395 Leu Arg Ala Val
Asp Ile Pro Gly Leu Glu Ala Ala Thr Pro Tyr 1400 1405 1410 Arg Val
Ser Ile Tyr Gly Val Ile Arg Gly Tyr Arg Thr Pro Val 1415 1420 1425
Leu Ser Ala Glu Ala Ser Thr Ala Lys Glu Pro Glu Ile Gly Asn 1430
1435 1440 Leu Asn Val Ser Asp Ile Thr Pro Glu Ser Phe Asn Leu Ser
Trp 1445 1450 1455 Met Ala Thr Asp Gly Ile Phe Glu Thr Phe Thr Ile
Glu Ile Ile 1460 1465 1470 Asp Ser Asn Arg Leu Leu Glu Thr Val Glu
Tyr Asn Ile Ser Gly 1475 1480 1485 Ala Glu Arg Thr Ala His Ile Ser
Gly Leu Pro Pro Ser Thr Asp 1490 1495 1500 Phe Ile Val Tyr Leu Ser
Gly Leu Ala Pro Ser Ile Arg Thr Lys 1505 1510 1515 Thr Ile Ser Ala
Thr Ala Thr Thr Glu Ala Leu Pro Leu Leu Glu 1520 1525 1530 Asn Leu
Thr Ile Ser Asp Ile Asn Pro Tyr Gly Phe Thr Val Ser 1535 1540 1545
Trp Met Ala Ser Glu Asn Ala Phe Asp Ser Phe Leu Val Thr Val 1550
1555 1560 Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu Phe Thr Leu
Ser 1565 1570 1575 Gly Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile
Thr Gly Ile 1580 1585 1590 Gly Tyr Glu Val Met Val Ser Gly Phe Thr
Gln Gly His Gln Thr 1595 1600 1605 Lys Pro Leu Arg Ala Glu Ile Val
Thr Glu Ala Glu Pro Glu Val 1610 1615 1620 Asp Asn Leu Leu Val Ser
Asp Ala Thr Pro Asp Gly Phe Arg Leu 1625 1630 1635 Ser Trp Thr Ala
Asp Glu Gly Val Phe Asp Asn Phe Val Leu Lys 1640 1645 1650 Ile Arg
Asp Thr Lys Lys Gln Ser Glu Pro Leu Glu Ile Thr Leu 1655 1660 1665
Leu Ala Pro Glu Arg Thr Arg Asp Ile Thr Gly Leu Arg Glu Ala 1670
1675 1680 Thr Glu Tyr Glu Ile Glu Leu Tyr Gly Ile Ser Lys Gly Arg
Arg 1685 1690 1695 Ser Gln Thr Val Ser Ala Ile Ala Thr Thr Ala Met
Gly Ser Pro 1700 1705 1710 Lys Glu Val Ile Phe Ser Asp Ile Thr Glu
Asn Ser Ala Thr Val 1715 1720 1725 Ser Trp Arg Ala Pro Thr Ala Gln
Val Glu Ser Phe Arg Ile Thr 1730 1735 1740 Tyr Val Pro Ile Thr Gly
Gly Thr Pro Ser Met Val Thr Val Asp 1745 1750 1755 Gly Thr Lys Thr
Gln Thr Arg Leu Val Lys Leu Ile Pro Gly Val 1760 1765 1770 Glu Tyr
Leu Val Ser Ile Ile Ala Met Lys Gly Phe Glu Glu Ser 1775 1780 1785
Glu Pro Val Ser Gly Ser Phe Thr Thr Ala Leu Asp Gly Pro Ser 1790
1795 1800 Gly Leu Val Thr Ala Asn Ile Thr Asp Ser Glu Ala Leu Ala
Arg 1805 1810 1815 Trp Gln Pro Ala Ile Ala Thr Val Asp Ser Tyr Val
Ile Ser Tyr 1820 1825 1830 Thr Gly Glu Lys Val Pro Glu Ile Thr Arg
Thr Val Ser Gly Asn 1835 1840 1845 Thr Val Glu Tyr Ala Leu Thr Asp
Leu Glu Pro Ala Thr Glu Tyr 1850 1855 1860 Thr Leu Arg Ile Phe Ala
Glu Lys Gly Pro Gln Lys Ser Ser Thr 1865 1870 1875 Ile Thr Ala Lys
Phe Thr Thr Asp Leu Asp Ser Pro Arg Asp Leu 1880 1885 1890 Thr Ala
Thr Glu Val Gln Ser Glu Thr Ala Leu Leu Thr Trp Arg 1895 1900 1905
Pro Pro Arg Ala Ser Val Thr Gly Tyr Leu Leu Val Tyr Glu Ser 1910
1915 1920 Val Asp Gly Thr Val Lys Glu Val Ile Val Gly Pro Asp Thr
Thr 1925 1930 1935 Ser Tyr Ser Leu Ala Asp Leu Ser Pro Ser Thr His
Tyr Thr Ala 1940 1945 1950 Lys Ile Gln Ala Leu Asn Gly Pro Leu Arg
Ser Asn Met Ile Gln 1955 1960 1965 Thr Ile Phe Thr Thr Ile Gly Leu
Leu Tyr Pro Phe Pro Lys Asp 1970 1975 1980 Cys Ser Gln Ala Met Leu
Asn Gly Asp Thr Thr Ser Gly Leu Tyr 1985 1990 1995 Thr Ile Tyr Leu
Asn Gly Asp Lys Ala Glu Ala Leu Glu Val Phe 2000 2005 2010 Cys Asp
Met Thr Ser Asp Gly Gly Gly Trp Ile Val Phe Leu Arg 2015 2020 2025
Arg Lys Asn Gly Arg Glu Asn Phe Tyr Gln Asn Trp Lys Ala Tyr 2030
2035 2040 Ala Ala Gly Phe Gly Asp Arg Arg Glu Glu Phe Trp Leu Gly
Leu 2045 2050 2055 Asp Asn Leu Asn Lys Ile Thr Ala Gln Gly Gln Tyr
Glu Leu Arg 2060 2065 2070 Val Asp Leu Arg Asp His Gly Glu Thr Ala
Phe Ala Val Tyr Asp 2075 2080 2085 Lys Phe Ser Val Gly Asp Ala Lys
Thr Arg Tyr Lys Leu Lys Val 2090 2095 2100 Glu Gly Tyr Ser Gly Thr
Ala Gly Asp Ser Met Ala Tyr His Asn 2105 2110 2115 Gly Arg Ser Phe
Ser Thr Phe Asp Lys Asp Thr Asp Ser Ala Ile 2120 2125 2130 Thr Asn
Cys Ala Leu Ser Tyr Lys Gly Ala Phe Trp Tyr Arg Asn 2135 2140 2145
Cys His Arg Val Asn Leu Met Gly Arg Tyr Gly Asp Asn Asn His 2150
2155 2160 Ser Gln Gly Val Asn Trp Phe His Trp Lys Gly His Glu His
Ser 2165 2170 2175 Ile Gln Phe Ala Glu Met Lys Leu Arg Pro Ser Asn
Phe Arg Asn 2180 2185 2190 Leu Glu Gly Arg Arg Lys Arg Ala 2195
2200 <210> SEQ ID NO 76 <211> LENGTH: 89 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Fibcon FN3 domain
<400> SEQUENCE: 76 Leu Asp Ala Pro Thr Asp Leu Gln Val Thr
Asn Val Thr Asp Thr Ser 1 5 10 15 Ile Thr Val Ser Trp Thr Pro Pro
Ser Ala Thr Ile Thr Gly Tyr Arg 20 25 30 Ile Thr Tyr Thr Pro Ser
Asn Gly Pro Gly Glu Pro Lys Glu Leu Thr 35 40 45 Val Pro Pro Ser
Ser Thr Ser Val Thr Ile Thr Gly Leu Thr Pro Gly 50 55 60 Val Glu
Tyr Val Val Ser Leu Tyr Ala Leu Lys Asp Asn Gln Glu Ser 65 70 75 80
Pro Pro Leu Val Gly Thr Gln Thr Thr 85 <210> SEQ ID NO 77
<211> LENGTH: 94 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 77 Val Ser Asp Val Pro Arg Asp
Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Leu Leu Ile Ser
Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 20 25 30 Arg Ile Thr
Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40 45 Thr
Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 50 55
60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp
65 70 75 80 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr
85 90 <210> SEQ ID NO 78 <211> LENGTH: 4 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: linker <400>
SEQUENCE: 78 Gly Ser Gly Ser 1 <210> SEQ ID NO 79 <211>
LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: linker
<400> SEQUENCE: 79 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser Gly Gly Gly Gly
Ser 20 25 <210> SEQ ID NO 80 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: linker
<400> SEQUENCE: 80 Ala Pro Ala Pro 1 <210> SEQ ID NO 81
<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: linker <400> SEQUENCE: 81 Ala Pro Ala Pro Ala
Pro Ala Pro Ala Pro 1 5 10 <210> SEQ ID NO 82 <211>
LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: linker
<400> SEQUENCE: 82 Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
Ala Pro Ala Pro Ala Pro 1 5 10 15 Ala Pro Ala Pro 20 <210>
SEQ ID NO 83 <211> LENGTH: 40 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: linker <400> SEQUENCE: 83 Ala
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 1 5 10
15 Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
20 25 30 Ala Pro Ala Pro Ala Pro Ala Pro 35 40 <210> SEQ ID
NO 84 <211> LENGTH: 29 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: linker <400> SEQUENCE: 84 Ala Glu Ala Ala
Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 1 5 10 15 Glu Ala
Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala 20 25 <210> SEQ
ID NO 85 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: tencon BC loop <400> SEQUENCE: 85 Thr Ala
Pro Asp Ala Ala Phe Asp 1 5 <210> SEQ ID NO 86 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: tencon
FG loop <400> SEQUENCE: 86 Lys Gly Gly His Arg Ser Asn 1 5
<210> SEQ ID NO 87 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain BC loop
<400> SEQUENCE: 87 Ala Asp Pro His Gly Phe Tyr Asp 1 5
<210> SEQ ID NO 88 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain BC loop
<400> SEQUENCE: 88 Thr Tyr Asp Arg Asp Gly Tyr Asp 1 5
<210> SEQ ID NO 89 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain BC loop
<400> SEQUENCE: 89 Trp Asp Pro Phe Ser Phe Tyr Asp 1 5
<210> SEQ ID NO 90 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain BC loop
<400> SEQUENCE: 90 Asp Asp Pro Arg Gly Phe Tyr Glu 1 5
<210> SEQ ID NO 91 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain BC loop
<400> SEQUENCE: 91 Thr Trp Pro Tyr Ala Asp Leu Asp 1 5
<210> SEQ ID NO 92 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain BC loop
<400> SEQUENCE: 92 Gly Tyr Asn Gly Asp His Phe Asp 1 5
<210> SEQ ID NO 93 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain BC loop
<400> SEQUENCE: 93 Asp Tyr Asp Leu Gly Val Tyr Asp 1 5
<210> SEQ ID NO 94 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain BC loop
<400> SEQUENCE: 94 Asp Asp Pro Trp Asp Phe Tyr Glu 1 5
<210> SEQ ID NO 95 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain FG loop
<400> SEQUENCE: 95 His Asn Val Tyr Lys Asp Thr Asn Met Arg
Gly Leu 1 5 10 <210> SEQ ID NO 96 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: EGFR binding
FN3 domain FG loop <400> SEQUENCE: 96 Leu Gly Ser Tyr Val Phe
Glu His Asp Val Met 1 5 10 <210> SEQ ID NO 97 <211>
LENGTH: 285 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: EGFR
binding FN3 domain from ECB97; P54AR4-83V22 <400> SEQUENCE:
97 atgttgccag cgccgaagaa cctggtagtt agcgaggtta ctgaggacag
cgcgcgtctg 60 agctgggacg atccgtgggc gttctacgag agctttctga
tccagtatca agagagcgag 120 aaagtcggtg aagcgattgt gctgaccgtc
ccgggctccg agcgttccta cgacctgacc 180 ggtttgaagc cgggtaccga
gtatacggtg agcatctacg gtgttcacaa tgtctataag 240 gacactaata
tccgcggtct gcctctgagc gccattttca ccacc 285 <210> SEQ ID NO 98
<211> LENGTH: 285 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain from ECB15; P54AR4-83V2
<400> SEQUENCE: 98 atgctgccag cccctaagaa tctggtcgtg
agcgaagtaa ccgaggacag cgcccgcctg 60 agctgggacg acccgtgggc
gttctatgag tctttcctga ttcagtatca agaaagcgaa 120 aaagttggcg
aagcgatcgt cctgaccgtc ccgggtagcg agcgctccta cgatctgacc 180
ggcctgaaac cgggtacgga gtacacggtg tccatttacg gtgttcacaa tgtgtataaa
240 gacaccaaca tgcgtggcct gccgctgtcg gcgattttca ccacc 285
<210> SEQ ID NO 99 <211> LENGTH: 89 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: tencon27 FN3 domain <400>
SEQUENCE: 99 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 65 70 75 80 Asn Pro Leu
Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 100 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: TCL14
library <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (32)..(32) <223> OTHER INFORMATION: Xaa
is any amino acid <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (34)..(34) <223> OTHER
INFORMATION: Xaa is any amino acid <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (36)..(36) <223>
OTHER INFORMATION: Xaa is any amino acid <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (38)..(38)
<223> OTHER INFORMATION: Xaa is any amino acid <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(39)..(39) <223> OTHER INFORMATION: Xaa is any amino acid
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Xaa is any
amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (41)..(41) <223> OTHER INFORMATION: Xaa
is any amino acid <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (68)..(68) <223> OTHER
INFORMATION: Xaa is any amino acid <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (70)..(70) <223>
OTHER INFORMATION: Xaa is any amino acid <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (72)..(72)
<223> OTHER INFORMATION: Xaa is any amino acid <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(78)..(78) <223> OTHER INFORMATION: Xaa is any amino acid
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (79)..(79) <223> OTHER INFORMATION: Xaa is any
amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (81)..(81) <223> OTHER INFORMATION: Xaa
is any amino acid <400> SEQUENCE: 100 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Xaa 20 25 30 Ile Xaa
Tyr Xaa Glu Xaa Xaa Xaa Xaa Gly Glu Ala Ile Val Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Gly Xaa Xaa
Ser 65 70 75 80 Xaa Pro Leu Ser Ala Ile Phe Thr Thr 85 <210>
SEQ ID NO 101 <211> LENGTH: 1408 <212> TYPE: PRT
<213> ORGANISM: HOMO SAPIENS <400> SEQUENCE: 101 Met
Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 1 5 10
15 Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
20 25 30 Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe
Thr Ala 35 40 45 Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His
His Ile Phe Leu 50 55 60 Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn
Glu Glu Asp Leu Gln Lys 65 70 75 80 Val Ala Glu Tyr Lys Thr Gly Pro
Val Leu Glu His Pro Asp Cys Phe 85 90 95 Pro Cys Gln Asp Cys Ser
Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 100 105 110 Lys Asp Asn Ile
Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 115 120 125 Gln Leu
Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 130 135 140
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 145
150 155 160 Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp
Cys Val 165 170 175 Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val
Lys Asp Arg Phe 180 185 190 Ile Asn Phe Phe Val Gly Asn Thr Ile Asn
Ser Ser Tyr Phe Pro Asp 195 200 205 His Pro Leu His Ser Ile Ser Val
Arg Arg Leu Lys Glu Thr Lys Asp 210 215 220 Gly Phe Met Phe Leu Thr
Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 225 230 235 240 Phe Arg Asp
Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 245 250 255 Asn
Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 260 265
270 Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
275 280 285 His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu
Lys Arg 290 295 300 Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile
Leu Gln Ala Ala 305 310 315 320 Tyr Val Ser Lys Pro Gly Ala Gln Leu
Ala Arg Gln Ile Gly Ala Ser 325 330 335 Leu Asn Asp Asp Ile Leu Phe
Gly Val Phe Ala Gln Ser Lys Pro Asp 340 345 350 Ser Ala Glu Pro Met
Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 355 360 365 Tyr Val Asn
Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 370 375 380 Cys
Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 385 390
395 400 Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu
Tyr 405 410 415 Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu
Phe Met Gly 420 425 430 Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser
Thr Phe Ile Lys Gly 435 440 445 Asp Leu Thr Ile Ala Asn Leu Gly Thr
Ser Glu Gly Arg Phe Met Gln 450 455 460 Val Val Val Ser Arg Ser Gly
Pro Ser Thr Pro His Val Asn Phe Leu 465 470 475 480 Leu Asp Ser His
Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 485 490 495 Asn Gln
Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 500 505 510
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 515
520 525 Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp
Lys 530 535 540 Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr
Gln Gln Ile 545 550 555 560 Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro
Asn Ser Ala Pro Leu Glu 565 570 575 Gly Gly Thr Arg Leu Thr Ile Cys
Gly Trp Asp Phe Gly Phe Arg Arg 580 585 590 Asn Asn Lys Phe Asp Leu
Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 595 600 605 Ser Cys Thr Leu
Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 610 615 620 Thr Val
Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 625 630 635
640 Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
645 650 655 Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala
Gly Gly 660 665 670 Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser
Gly Asn Ser Arg 675 680 685 His Ile Ser Ile Gly Gly Lys Thr Cys Thr
Leu Lys Ser Val Ser Asn 690 695 700 Ser Ile Leu Glu Cys Tyr Thr Pro
Ala Gln Thr Ile Ser Thr Glu Phe 705 710 715 720 Ala Val Lys Leu Lys
Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 725 730 735 Ser Tyr Arg
Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 740 745 750 Phe
Ile Ser Thr Trp Trp Lys Glu Pro Leu Asn Ile Val Ser Phe Leu 755 760
765 Phe Cys Phe Ala Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn
770 775 780 Leu Asn Ser Val Ser Val Pro Arg Met Val Ile Asn Val His
Glu Ala 785 790 795 800 Gly Arg Asn Phe Thr Val Ala Cys Gln His Arg
Ser Asn Ser Glu Ile 805 810 815 Ile Cys Cys Thr Thr Pro Ser Leu Gln
Gln Leu Asn Leu Gln Leu Pro 820 825 830 Leu Lys Thr Lys Ala Phe Phe
Met Leu Asp Gly Ile Leu Ser Lys Tyr 835 840 845 Phe Asp Leu Ile Tyr
Val His Asn Pro Val Phe Lys Pro Phe Glu Lys 850 855 860 Pro Val Met
Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly 865 870 875 880
Asn Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly 885
890 895 Asn Lys Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu
Cys 900 905 910 Thr Val Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu
Asn Ile Glu 915 920 925 Trp Lys Gln Ala Ile Ser Ser Thr Val Leu Gly
Lys Val Ile Val Gln 930 935 940 Pro Asp Gln Asn Phe Thr Gly Leu Ile
Ala Gly Val Val Ser Ile Ser 945 950 955 960 Thr Ala Leu Leu Leu Leu
Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg 965 970 975 Lys Gln Ile Lys
Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg 980 985 990 Val His
Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser 995 1000
1005 Pro Thr Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala
1010 1015 1020 Thr Phe Pro Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn
Gly Ser 1025 1030 1035 Cys Arg Gln Val Gln Tyr Pro Leu Thr Asp Met
Ser Pro Ile Leu 1040 1045 1050 Thr Ser Gly Asp Ser Asp Ile Ser Ser
Pro Leu Leu Gln Asn Thr 1055 1060 1065 Val His Ile Asp Leu Ser Ala
Leu Asn Pro Glu Leu Val Gln Ala 1070 1075 1080 Val Gln His Val Val
Ile Gly Pro Ser Ser Leu Ile Val His Phe 1085 1090 1095 Asn Glu Val
Ile Gly Arg Gly His Phe Gly Cys Val Tyr His Gly 1100 1105 1110 Thr
Leu Leu Asp Asn Asp Gly Lys Lys Ile His Cys Ala Val Lys 1115 1120
1125 Ser Leu Asn Arg Ile Thr Asp Ile Gly Glu Val Ser Gln Phe Leu
1130 1135 1140 Thr Glu Gly Ile Ile Met Lys Asp Phe Ser His Pro Asn
Val Leu 1145 1150 1155 Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu Gly
Ser Pro Leu Val 1160 1165 1170 Val Leu Pro Tyr Met Lys His Gly Asp
Leu Arg Asn Phe Ile Arg 1175 1180 1185 Asn Glu Thr His Asn Pro Thr
Val Lys Asp Leu Ile Gly Phe Gly 1190 1195 1200 Leu Gln Val Ala Lys
Gly Met Lys Tyr Leu Ala Ser Lys Lys Phe 1205 1210 1215 Val His Arg
Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu Lys 1220 1225 1230 Phe
Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr 1235 1240
1245 Asp Lys Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys Leu
1250 1255 1260 Pro Val Lys Trp Met Ala Leu Glu Ser Leu Gln Thr Gln
Lys Phe 1265 1270 1275 Thr Thr Lys Ser Asp Val Trp Ser Phe Gly Val
Leu Leu Trp Glu 1280 1285 1290 Leu Met Thr Arg Gly Ala Pro Pro Tyr
Pro Asp Val Asn Thr Phe 1295 1300 1305 Asp Ile Thr Val Tyr Leu Leu
Gln Gly Arg Arg Leu Leu Gln Pro 1310 1315 1320 Glu Tyr Cys Pro Asp
Pro Leu Tyr Glu Val Met Leu Lys Cys Trp 1325 1330 1335 His Pro Lys
Ala Glu Met Arg Pro Ser Phe Ser Glu Leu Val Ser 1340 1345 1350 Arg
Ile Ser Ala Ile Phe Ser Thr Phe Ile Gly Glu His Tyr Val 1355 1360
1365 His Val Asn Ala Thr Tyr Val Asn Val Lys Cys Val Ala Pro Tyr
1370 1375 1380 Pro Ser Leu Leu Ser Ser Glu Asp Asn Ala Asp Asp Glu
Val Asp 1385 1390 1395 Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser 1400
1405 <210> SEQ ID NO 102 <211> LENGTH: 697 <212>
TYPE: PRT <213> ORGANISM: HOMO SAPIENS <400> SEQUENCE:
102 Gln Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys
1 5 10 15 Thr Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr
Lys Lys 20 25 30 Val Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr
Arg Asn Lys Gly 35 40 45 Leu Pro Phe Thr Cys Lys Ala Phe Val Phe
Asp Lys Ala Arg Lys Gln 50 55 60 Cys Leu Trp Phe Pro Phe Asn Ser
Met Ser Ser Gly Val Lys Lys Glu 65 70 75 80 Phe Gly His Glu Phe Asp
Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn 85 90 95 Cys Ile Ile Gly
Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr 100 105 110 Lys Ser
Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu 115 120 125
His Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn 130
135 140 Tyr Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe
Thr 145 150 155 160 Ser Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile
Pro Gln Cys Ser 165 170 175 Glu Val Glu Cys Met Thr Cys Asn Gly Glu
Ser Tyr Arg Gly Leu Met 180 185 190 Asp His Thr Glu Ser Gly Lys Ile
Cys Gln Arg Trp Asp His Gln Thr 195 200 205 Pro His Arg His Lys Phe
Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe 210 215 220 Asp Asp Asn Tyr
Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys 225 230 235 240 Tyr
Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr 245 250
255 Cys Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr
260 265 270 Glu Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val
Asn Thr 275 280 285 Ile Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser
Gln Tyr Pro His 290 295 300 Glu His Asp Met Thr Pro Glu Asn Phe Lys
Cys Lys Asp Leu Arg Glu 305 310 315 320 Asn Tyr Cys Arg Asn Pro Asp
Gly Ser Glu Ser Pro Trp Cys Phe Thr 325 330 335 Thr Asp Pro Asn Ile
Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys 340 345 350 Asp Met Ser
His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr 355 360 365 Met
Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp 370 375
380 Asp Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp
385 390 395 400 Ala Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp
Asp Asp Ala 405 410 415 His Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu
Ile Pro Trp Asp Tyr 420 425 430 Cys Pro Ile Ser Arg Cys Glu Gly Asp
Thr Thr Pro Thr Ile Val Asn 435 440 445 Leu Asp His Pro Val Ile Ser
Cys Ala Lys Thr Lys Gln Leu Arg Val 450 455 460 Val Asn Gly Ile Pro
Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu 465 470 475 480 Arg Tyr
Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser 485 490 495
Trp Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp 500
505 510 Tyr Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp
Glu 515 520 525 Lys Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr
Gly Pro Glu 530 535 540 Gly Ser Asp Leu Val Leu Met Lys Leu Ala Arg
Pro Ala Val Leu Asp 545 550 555 560 Asp Phe Val Ser Thr Ile Asp Leu
Pro Asn Tyr Gly Cys Thr Ile Pro 565 570 575 Glu Lys Thr Ser Cys Ser
Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile 580 585 590 Asn Tyr Asp Gly
Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn 595 600 605 Glu Lys
Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser 610 615 620
Glu Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly 625
630 635 640 Asp Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg
Met Val 645 650 655 Leu Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile
Pro Asn Arg Pro 660 665 670 Gly Ile Phe Val Arg Val Ala Tyr Tyr Ala
Lys Trp Ile His Lys Ile 675 680 685 Ile Leu Thr Tyr Lys Val Pro Gln
Ser 690 695 <210> SEQ ID NO 103 <211> LENGTH: 276
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: c-Met binding
FN3 domain <400> SEQUENCE: 103 ctgccggctc cgaagaactt
ggtggtgagc cgtgttaccg aagatagcgc acgcctgagc 60 tggacggcac
cggatgcggc gttcgatagc ttctggattc gctattttga gtttctgggt 120
agcggtgagg caattgttct gacggtgccg ggctctgaac gctcctacga tttgaccggt
180 ctgaaaccgg gcaccgagta tgtggtgaac attctgagcg ttaagggcgg
tagcatcagc 240 ccaccgctga gcgcgatctt cacgactggt ggttgc 276
<210> SEQ ID NO 104 <211> LENGTH: 267 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain <400>
SEQUENCE: 104 ctgccggcac cgaagaacct ggttgtcagc cgtgtgaccg
aggatagcgc acgtttgagc 60 tggaccgctc cggatgcagc ctttgacagc
ttctggattc gttactttga atttctgggt 120 agcggtgagg cgatcgttct
gacggtgccg ggctctgaac gcagctatga tttgacgggc 180 ctgaagccgg
gtactgagta cgtggttaac atcatgggcg ttaagggtgg taaaatcagc 240
ccgccattgt ccgcgatctt taccacg 267 <210> SEQ ID NO 105
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: linker <400> SEQUENCE: 105 Gly Gly Gly Gly Ser 1
5 <210> SEQ ID NO 106 <211> LENGTH: 194 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Bispecific EGFR/c-Met
binding molecule <400> SEQUENCE: 106 Met Leu Pro Ala Pro Lys
Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu
Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile
Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50
55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr
Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe
Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro
Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser
Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser
Phe Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala
Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp
Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175
Leu Ser Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe 180
185 190 Thr Thr <210> SEQ ID NO 107 <211> LENGTH: 94
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: EGFR binding
FN3 domain <400> SEQUENCE: 107 Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp
Ala Asp Pro His Gly Phe Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55
60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp
65 70 75 80 Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr
85 90 <210> SEQ ID NO 108 <211> LENGTH: 94 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 108 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
Trp Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr 85 90
<210> SEQ ID NO 109 <211> LENGTH: 94 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 109 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro His Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Ile
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr 85 90 <210> SEQ
ID NO 110 <211> LENGTH: 94 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: EGFR binding FN3 domain <400> SEQUENCE:
110 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser
1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser
Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala
Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu
Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val Ser Ile Tyr
Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Ile Arg Gly Leu
Pro Leu Ser Ala Ile Phe Thr Thr 85 90 <210> SEQ ID NO 111
<211> LENGTH: 89 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: c-Met binding FN3 domain <400> SEQUENCE: 111 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10
15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp
20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile Val
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val Asn Ile Leu Gly Val
Lys Gly Gly Lys Ile Ser 65 70 75 80 Pro Pro Leu Ser Ala Ile Phe Thr
Thr 85 <210> SEQ ID NO 112 <211> LENGTH: 89 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: c-Met binding FN3 domain
<400> SEQUENCE: 112 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe
Val Gly Ser Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Val Val Asn Ile Leu Gly Val Lys Gly Gly Ser Ile Ser 65 70 75 80
Pro Pro Leu Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 113
<211> LENGTH: 89 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: c-Met binding FN3 domain <400> SEQUENCE: 113 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10
15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp
20 25 30 Ile Arg Tyr Phe Glu Phe Val Ser Lys Gly Asp Ala Ile Val
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val Asn Ile Leu Gly Val
Lys Gly Gly Ser Ile Ser 65 70 75 80 Pro Pro Leu Ser Ala Ile Phe Thr
Thr 85 <210> SEQ ID NO 114 <211> LENGTH: 89 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: c-Met binding FN3 domain
<400> SEQUENCE: 114 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe
Leu Gly Ser Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Val Val Asn Ile Leu Ser Val Lys Gly Gly Ser Ile Ser 65 70 75 80
Pro Pro Leu Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 115
<211> LENGTH: 591 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding molecule <400>
SEQUENCE: 115 atgttgccag cgccgaagaa cctggtagtt agcgaggtta
ctgaggacag cgcgcgtctg 60 agctgggacg atccgtgggc gttctacgag
agctttctga tccagtatca agagagcgag 120 aaagtcggtg aagcgattgt
gctgaccgtc ccgggctccg agcgttccta cgacctgacc 180 ggtttgaagc
cgggtaccga gtatacggtg agcatctacg gtgttcacaa tgtctataag 240
gacactaata tccgcggtct gcctctgagc gccattttca ccaccgcacc ggcaccggct
300 ccggctcctg ccccgctgcc ggctccgaag aacttggtgg tgagccgtgt
taccgaagat 360 agcgcacgcc tgagctggac ggcaccggat gcggcgttcg
atagcttctg gattcgctat 420 tttgagtttc tgggtagcgg tgaggcaatt
gttctgacgg tgccgggctc tgaacgctcc 480 tacgatttga ccggtctgaa
accgggcacc gagtatgtgg tgaacattct gagcgttaag 540 ggcggtagca
tcagcccacc gctgagcgcg atcttcacga ctggtggttg c 591 <210> SEQ
ID NO 116 <211> LENGTH: 582 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding molecule
<400> SEQUENCE: 116 atgctgccag cccctaagaa tctggtcgtg
agcgaagtaa ccgaggacag cgcccgcctg 60 agctgggacg acccgtgggc
gttctatgag tctttcctga ttcagtatca agaaagcgaa 120 aaagttggcg
aagcgatcgt cctgaccgtc ccgggtagcg agcgctccta cgatctgacc 180
ggcctgaaac cgggtacgga gtacacggtg tccatttacg gtgttcacaa tgtgtataaa
240 gacaccaaca tgcgtggcct gccgctgtcg gcgattttca ccaccgcgcc
tgcgccagcg 300 cctgcaccgg ctccgctgcc ggcaccgaag aacctggttg
tcagccgtgt gaccgaggat 360 agcgcacgtt tgagctggac cgctccggat
gcagcctttg acagcttctg gattcgttac 420 tttgaatttc tgggtagcgg
tgaggcgatc gttctgacgg tgccgggctc tgaacgcagc 480 tatgatttga
cgggcctgaa gccgggtact gagtacgtgg ttaacatcat gggcgttaag 540
ggtggtaaaa tcagcccgcc attgtccgcg atctttacca cg 582 <210> SEQ
ID NO 117 <211> LENGTH: 51 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: albumin binding domain <400> SEQUENCE: 117
Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile Glu 1 5
10 15 Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu
Ile 20 25 30 Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys
Asp Glu Ile 35 40 45 Leu Lys Ala 50 <210> SEQ ID NO 118
<211> LENGTH: 250 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding molecule <400>
SEQUENCE: 118 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Asp Glu
Val Val 130 135 140 Val Gly Gly Glu Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Tyr Val Asn Ile 165 170 175 Leu Gly Val Lys Gly Gly Ser
Ile Ser Val Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr Ala Pro Ala
Pro Ala Pro Ala Pro Ala Pro Leu Ala Glu Ala 195 200 205 Lys Val Leu
Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr 210 215 220 Tyr
Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala 225 230
235 240 Leu Leu Asp Glu Ile Leu Ala Ala Leu Pro 245 250 <210>
SEQ ID NO 119 <211> LENGTH: 250 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding
molecule <400> SEQUENCE: 119 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Ala Asp Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Asp Glu Val Val 130 135 140 Val Gly Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Tyr Val Asn Ile 165 170 175 Leu
Gly Val Lys Gly Gly Ser Ile Ser Val Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Ala Glu Ala
195 200 205 Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser
Asp Tyr 210 215 220 Tyr Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu
Gly Val Lys Ala 225 230 235 240 Leu Leu Asp Glu Ile Leu Ala Ala Leu
Pro 245 250 <210> SEQ ID NO 120 <211> LENGTH: 250
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Bispecific
EGFR/c-Met binding molecule <400> SEQUENCE: 120 Met Leu Pro
Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser
Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25
30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu
35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu
Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His
Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser
Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala
Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr
Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala
Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser
Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155
160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile
165 170 175 Met Gly Val Lys Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala
Ile Phe 180 185 190 Thr Thr Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
Leu Ala Glu Ala 195 200 205 Lys Val Leu Ala Asn Arg Glu Leu Asp Lys
Tyr Gly Val Ser Asp Tyr 210 215 220 Tyr Lys Asn Leu Ile Asn Asn Ala
Lys Thr Val Glu Gly Val Lys Ala 225 230 235 240 Leu Leu Asp Glu Ile
Leu Ala Ala Leu Pro 245 250 <210> SEQ ID NO 121 <211>
LENGTH: 250 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Bispecific EGFR/c-Met binding molecule <400> SEQUENCE: 121
Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5
10 15 Ser Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser
Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala
Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu
Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr
Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu
Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro
Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser
Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro
Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu 130 135
140 Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser
145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val
Val Asn Ile 165 170 175 Met Gly Val Lys Gly Gly Lys Ile Ser Pro Pro
Leu Ser Ala Ile Phe 180 185 190 Thr Thr Ala Pro Ala Pro Ala Pro Ala
Pro Ala Pro Leu Ala Glu Ala 195 200 205 Lys Val Leu Ala Asn Arg Glu
Leu Asp Lys Tyr Gly Val Ser Asp Tyr 210 215 220 Tyr Lys Asn Leu Ile
Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala 225 230 235 240 Leu Leu
Asp Glu Ile Leu Ala Ala Leu Pro 245 250 <210> SEQ ID NO 122
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 122 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Leu Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Glu Phe Thr Thr 85 90 95 <210> SEQ ID NO 123
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 123 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Leu Arg Leu Ser Trp Thr Tyr Asp Arg Asp Gly Tyr Asp Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Glu Phe Thr Thr 85 90 95 <210> SEQ ID NO 124
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 124 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Leu Arg Leu Ser Trp Gly Tyr Asn Gly Asp His Phe Asp Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Glu Phe Thr Thr 85 90 95 <210> SEQ ID NO 125
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 125 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Leu Arg Leu Ser Trp Asp Asp Pro Arg Gly Phe Tyr Glu Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Glu Phe Thr Thr 85 90 95 <210> SEQ ID NO 126
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 126 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Leu Arg Leu Ser Trp Thr Trp Pro Tyr Ala Asp Leu Asp Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Glu Phe Thr Thr 85 90 95 <210> SEQ ID NO 127
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 127 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Leu Arg Leu Ser Trp Gly Tyr Asn Gly Asp His Phe Asp Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Glu Phe Thr Thr 85 90 95 <210> SEQ ID NO 128
<211> LENGTH: 96 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 128 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Leu Arg Leu Ser Trp Asp Tyr Asp Leu Gly Val Tyr Phe Asp Ser
20 25 30 Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala
Ile Asn 35 40 45 Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu
Thr Gly Leu Lys 50 55 60 Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr
Gly Val His Asn Val Tyr 65 70 75 80 Lys Asp Thr Asn Met Arg Gly Leu
Pro Leu Ser Ala Glu Phe Thr Thr 85 90 95 <210> SEQ ID NO 129
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 129 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Leu Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Glu Phe Thr Thr 85 90 95 <210> SEQ ID NO 130
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 130 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val Leu Gly Ser Tyr Val 65 70 75 80 Phe Glu His Asp Val Met Leu Pro
Leu Ser Ala Glu Phe Thr Thr 85 90 95 <210> SEQ ID NO 131
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 131 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Ile Phe Thr Thr 85 90 95 <210> SEQ ID NO 132
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 132 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val Leu Gly Ser Tyr Val 65 70 75 80 Phe Glu His Asp Val Met Leu Pro
Leu Ser Ala Ile Phe Thr Thr 85 90 95 <210> SEQ ID NO 133
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 133 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Leu Arg Leu Ser Trp Thr Trp Pro Tyr Ala Asp Leu Asp Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Glu Phe Thr Thr 85 90 95 <210> SEQ ID NO 134
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 134 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Ile Phe Thr Thr 85 90 95 <210> SEQ ID NO 135
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 135 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro
Leu Ser Ala Ile Phe Thr Thr 85 90 95 <210> SEQ ID NO 136
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 136 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Ala Arg Leu Ser Trp Asp Asp Pro His Ala Phe Tyr Glu Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro
Leu Ser Ala Ile Phe Thr Thr 85 90 95 <210> SEQ ID NO 137
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 137 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro
Leu Ser Ala Ile Phe Thr Thr 85 90 95 <210> SEQ ID NO 138
<211> LENGTH: 204 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 138 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85 90 95 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 100 105
110 Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
115 120 125 Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp 130 135 140 Ser Phe Trp Ile Arg Tyr Asp Glu Val Val Val Gly
Gly Glu Ala Ile 145 150 155 160 Val Leu Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu 165 170 175 Lys Pro Gly Thr Glu Tyr Tyr
Val Asn Ile Leu Gly Val Lys Gly Gly 180 185 190 Ser Ile Ser Val Pro
Leu Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID NO 139
<211> LENGTH: 203 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 139 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85 90 95 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 100 105
110 Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu
115 120 125 Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe
Asp Ser 130 135 140 Phe Trp Ile Arg Tyr Phe Glu Phe Leu Gly Ser Gly
Glu Ala Ile Val 145 150 155 160 Leu Thr Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys 165 170 175 Pro Gly Thr Glu Tyr Val Val
Asn Ile Met Gly Val Lys Gly Gly Lys 180 185 190 Ile Ser Pro Pro Leu
Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID NO 140
<211> LENGTH: 204 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 140 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85 90 95 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 100 105
110 Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
115 120 125 Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp 130 135 140 Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile 145 150 155 160 Val Leu Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu 165 170 175 Lys Pro Gly Thr Glu Tyr Val
Val Gln Ile Ile Gly Val Lys Gly Gly 180 185 190 His Ile Ser Leu Pro
Leu Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID NO 141
<211> LENGTH: 204 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 141 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85 90 95 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 100 105
110 Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
115 120 125 Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp 130 135 140 Ser Phe Phe Ile Arg Tyr Asp Glu Phe Leu Arg Ser
Gly Glu Ala Ile 145 150 155 160 Val Leu Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu 165 170 175 Lys Pro Gly Thr Glu Tyr Trp
Val Thr Ile Leu Gly Val Lys Gly Gly 180 185 190 Leu Val Ser Thr Pro
Leu Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID NO 142
<211> LENGTH: 204 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 142 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe
Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85 90 95 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 100 105
110 Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
115 120 125 Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp 130 135 140 Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile 145 150 155 160 Val Leu Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu 165 170 175 Lys Pro Gly Thr Glu Tyr Val
Val Asn Ile Met Gly Val Lys Gly Gly 180 185 190 Lys Ile Ser Pro Pro
Leu Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID NO 143
<211> LENGTH: 204 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 143 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe
Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85 90 95 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 100 105
110 Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
115 120 125 Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp 130 135 140 Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile 145 150 155 160 Val Leu Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu 165 170 175 Lys Pro Gly Thr Glu Tyr Val
Val Gln Ile Ile Gly Val Lys Gly Gly 180 185 190 His Ile Ser Leu Pro
Leu Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID NO 144
<211> LENGTH: 204 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 144 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe
Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85 90 95 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 100 105
110 Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
115 120 125 Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp 130 135 140 Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile 145 150 155 160 Val Leu Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu 165 170 175 Lys Pro Gly Thr Glu Tyr Val
Val Gln Ile Ile Gly Val Lys Gly Gly 180 185 190 His Ile Ser Leu Pro
Leu Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID NO 145
<211> LENGTH: 193 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 145 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105
110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe
Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser
Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr
Glu Tyr Val Val Asn Ile Met 165 170 175 Gly Val Lys Gly Gly Lys Ile
Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr <210> SEQ
ID NO 146 <211> LENGTH: 193 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 146 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105
110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Asp Glu Val
Val Val 130 135 140 Gly Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser
Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr
Glu Tyr Tyr Val Asn Ile Leu 165 170 175 Gly Val Lys Gly Gly Ser Ile
Ser Val Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr <210> SEQ
ID NO 147 <211> LENGTH: 194 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 147 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe
Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Met Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu
Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Val Val Asn Ile 165 170 175 Met Gly Val Lys Gly Gly Lys
Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr <210>
SEQ ID NO 148 <211> LENGTH: 193 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 148 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro
His Gly Phe Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Asp Glu Val Val Val 130 135 140 Gly Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Tyr Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Ser Ile Ser Val Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 149 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 149 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
Trp Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 150 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 150 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
Trp Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Val Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 151 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 151 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
Trp Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Val Ser 130 135 140 Lys Gly Asp Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 152 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 152 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
Trp Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Ser Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 153 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 153 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
His Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 154 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 154 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
His Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Val Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 155 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 155 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
His Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Val Ser 130 135 140 Lys Gly Asp Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 156 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 156 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
His Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Ser Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 157 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 157 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro
His Gly Phe Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 158 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 158 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro
His Gly Phe Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Val Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 159 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 159 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro
His Gly Phe Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Val Ser 130 135 140 Lys Gly Asp Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 160 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 160 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro
His Gly Phe Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Ser Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 161 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 161 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
Trp Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Ser Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 162 <211> LENGTH: 249 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 162 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
Trp Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Asp Glu Val Val Val 130 135 140 Gly Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Tyr Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Ser Ile Ser Val Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr Ala
Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Ala Glu Ala Lys 195 200 205
Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr Tyr 210
215 220 Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala
Leu 225 230 235 240 Leu Asp Glu Ile Leu Ala Ala Leu Pro 245
<210> SEQ ID NO 163 <211> LENGTH: 249 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 163 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro
His Gly Phe Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Asp Glu Val Val Val 130 135 140 Gly Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Tyr Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Ser Ile Ser Val Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr Ala
Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Ala Glu Ala Lys 195 200 205
Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr Tyr 210
215 220 Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala
Leu 225 230 235 240 Leu Asp Glu Ile Leu Ala Ala Leu Pro 245
<210> SEQ ID NO 164 <211> LENGTH: 249 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 164 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
Trp Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Met 165 170 175 Gly Val Lys Gly
Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr Ala
Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Ala Glu Ala Lys 195 200 205
Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr Tyr 210
215 220 Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala
Leu 225 230 235 240 Leu Asp Glu Ile Leu Ala Ala Leu Pro 245
<210> SEQ ID NO 165 <211> LENGTH: 249 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 165 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro
His Gly Phe Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Met 165 170 175 Gly Val Lys Gly
Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr Ala
Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Ala Glu Ala Lys 195 200 205
Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr Tyr 210
215 220 Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala
Leu 225 230 235 240 Leu Asp Glu Ile Leu Ala Ala Leu Pro 245
<210> SEQ ID NO 166 <211> LENGTH: 588 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 166 ttgccagcgc cgaagaacct ggtagttagc
gaggttactg aggacagcgc gcgtctgagc 60 tgggacgatc cgtgggcgtt
ctacgagagc tttctgatcc agtatcaaga gagcgagaaa 120 gtcggtgaag
cgattgtgct gaccgtcccg ggctccgagc gttcctacga cctgaccggt 180
ttgaagccgg gtaccgagta tacggtgagc atctacggtg ttcacaatgt ctataaggac
240 actaatatcc gcggtctgcc tctgagcgcc attttcacca ccgcaccggc
accggctccg 300 gctcctgccc cgctgccggc tccgaagaac ttggtggtga
gccgtgttac cgaagatagc 360 gcacgcctga gctggacggc accggatgcg
gcgttcgata gcttctggat tcgctatttt 420 gagtttctgg gtagcggtga
ggcaattgtt ctgacggtgc cgggctctga acgctcctac 480 gatttgaccg
gtctgaaacc gggcaccgag tatgtggtga acattctgag cgttaagggc 540
ggtagcatca gcccaccgct gagcgcgatc ttcacgactg gtggttgc 588
<210> SEQ ID NO 167 <211> LENGTH: 579 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 167 ctgccagccc ctaagaatct ggtcgtgagc
gaagtaaccg aggacagcgc ccgcctgagc 60 tgggacgacc cgtgggcgtt
ctatgagtct ttcctgattc agtatcaaga aagcgaaaaa 120 gttggcgaag
cgatcgtcct gaccgtcccg ggtagcgagc gctcctacga tctgaccggc 180
ctgaaaccgg gtacggagta cacggtgtcc atttacggtg ttcacaatgt gtataaagac
240 accaacatgc gtggcctgcc gctgtcggcg attttcacca ccgcgcctgc
gccagcgcct 300 gcaccggctc cgctgccggc accgaagaac ctggttgtca
gccgtgtgac cgaggatagc 360 gcacgtttga gctggaccgc tccggatgca
gcctttgaca gcttctggat tcgttacttt 420 gaatttctgg gtagcggtga
ggcgatcgtt ctgacggtgc cgggctctga acgcagctat 480 gatttgacgg
gcctgaagcc gggtactgag tacgtggtta acatcatggg cgttaagggt 540
ggtaaaatca gcccgccatt gtccgcgatc tttaccacg 579 <210> SEQ ID
NO 168 <211> LENGTH: 282 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: EGFR binding FN3 domain from ECB97 <400>
SEQUENCE: 168 ttgccagcgc cgaagaacct ggtagttagc gaggttactg
aggacagcgc gcgtctgagc 60 tgggacgatc cgtgggcgtt ctacgagagc
tttctgatcc agtatcaaga gagcgagaaa 120 gtcggtgaag cgattgtgct
gaccgtcccg ggctccgagc gttcctacga cctgaccggt 180 ttgaagccgg
gtaccgagta tacggtgagc atctacggtg ttcacaatgt ctataaggac 240
actaatatcc gcggtctgcc tctgagcgcc attttcacca cc 282 <210> SEQ
ID NO 169 <211> LENGTH: 282 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: EGFR binding FN3 domain from ECB15 <400>
SEQUENCE: 169 ctgccagccc ctaagaatct ggtcgtgagc gaagtaaccg
aggacagcgc ccgcctgagc 60 tgggacgacc cgtgggcgtt ctatgagtct
ttcctgattc agtatcaaga aagcgaaaaa 120 gttggcgaag cgatcgtcct
gaccgtcccg ggtagcgagc gctcctacga tctgaccggc 180 ctgaaaccgg
gtacggagta cacggtgtcc atttacggtg ttcacaatgt gtataaagac 240
accaacatgc gtggcctgcc gctgtcggcg attttcacca cc 282 <210> SEQ
ID NO 170 <211> LENGTH: 195 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding molecule
<400> SEQUENCE: 170 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp
Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu
Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr
Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80
Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85
90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn
Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg
Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile Val Leu Thr
Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu
Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Gly Val Lys
Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr
Cys 195 <210> SEQ ID NO 171 <211> LENGTH: 195
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Bispecific
EGFR/c-Met binding molecule <400> SEQUENCE: 171 Met Leu Pro
Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser
Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25
30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu
35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu
Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His
Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser
Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala
Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr
Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala
Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140 Gly Ser
Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155
160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile
165 170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala
Ile Phe 180 185 190 Thr Thr Cys 195 <210> SEQ ID NO 172
<211> LENGTH: 195 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding molecule <400>
SEQUENCE: 172 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu
Phe Val 130 135 140 Ser Lys Gly Asp Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Gly Val Lys Gly Gly Ser
Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr Cys 195
<210> SEQ ID NO 173 <211> LENGTH: 195 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding
molecule <400> SEQUENCE: 173 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu
Ser Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr Cys 195 <210> SEQ ID NO 174 <211> LENGTH:
195 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Bispecific
EGFR/c-Met binding molecule <400> SEQUENCE: 174 Met Leu Pro
Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser
Ala Arg Leu Ser Trp Asp Asp Pro His Ala Phe Tyr Glu Ser Phe 20 25
30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu
35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu
Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His
Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser
Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala
Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr
Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala
Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser
Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155
160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile
165 170 175 Leu Gly Val Lys Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala
Ile Phe 180 185 190 Thr Thr Cys 195 <210> SEQ ID NO 175
<211> LENGTH: 195 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding molecule <400>
SEQUENCE: 175 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro His Ala
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu
Phe Val 130 135 140 Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Gly Val Lys Gly Gly Ser
Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr Cys 195
<210> SEQ ID NO 176 <211> LENGTH: 195 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding
molecule <400> SEQUENCE: 176 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro His Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140 Ser Lys Gly Asp Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu
Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr Cys 195 <210> SEQ ID NO 177 <211> LENGTH:
195 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Bispecific
EGFR/c-Met binding molecule <400> SEQUENCE: 177 Met Leu Pro
Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser
Ala Arg Leu Ser Trp Asp Asp Pro His Ala Phe Tyr Glu Ser Phe 20 25
30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu
35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu
Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His
Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser
Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala
Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr
Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala
Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser
Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155
160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile
165 170 175 Leu Ser Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala
Ile Phe 180 185 190 Thr Thr Cys 195 <210> SEQ ID NO 178
<211> LENGTH: 195 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding molecule <400>
SEQUENCE: 178 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu
Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Ser Val Lys Gly Gly Ser
Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr Cys 195
<210> SEQ ID NO 179 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Consensus FG loop of EGFR bindiing
FN3 domain <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (9)..(9) <223> OTHER INFORMATION: Xaa
may be Met or Ile <400> SEQUENCE: 179 His Asn Val Tyr Lys Asp
Thr Asn Xaa Arg Gly Leu 1 5 10 <210> SEQ ID NO 180
<211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: GF loop of EGFR binding FN3 domain <400>
SEQUENCE: 180 Leu Gly Ser Tyr Val Phe Glu His Asp Val Met Leu 1 5
10 <210> SEQ ID NO 181 <211> LENGTH: 8 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Consensus BC loop of EGFR
binding FN3 domain <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (1)..(1) <223> OTHER
INFORMATION: Xaa may be Ala, Thr, Gly or Asp <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa may be Ala, Asp, Tyr or Trp
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (3)..(3) <223> OTHER INFORMATION: Xaa may be Pro,
Asp or Asn <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (4)..(4) <223> OTHER INFORMATION: Xaa
may be Leu or absent <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (5)..(5) <223> OTHER
INFORMATION: Xaa may be Asp, His, Arg, Gly, Tyr or Trp <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(6)..(6) <223> OTHER INFORMATION: Xaa may be Glu, Asp or Ala
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (7)..(7) <223> OTHER INFORMATION: Xaa may be Ala,
Phe, Gly, His or Asp <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (8)..(8) <223> OTHER
INFORMATION: Xaa may be Tyr, Phe or Leu <400> SEQUENCE: 181
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 <210> SEQ ID NO 182
<211> LENGTH: 95 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain consensus sequence <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(22)..(22) <223> OTHER INFORMATION: Xaa may be Ala, Thr, Gly
or Asp <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (23)..(23) <223> OTHER INFORMATION: Xaa
may be Ala, Asp, Tyr or Trp <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (24)..(24) <223>
OTHER INFORMATION: Xaa may be Pro, Asp or Asn <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (25)..(25)
<223> OTHER INFORMATION: Xaa may be Leu or absent <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(26)..(26) <223> OTHER INFORMATION: Xaa may be Asp, His, Arg,
Gly, Tyr or Trp <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (27)..(27) <223> OTHER INFORMATION: Xaa
may be Gly, Asp or Ala <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (28)..(28) <223> OTHER
INFORMATION: Xaa may be Ala, Phe, Gly, His or Asp <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(29)..(29) <223> OTHER INFORMATION: Xaa may be Tyr, Phe or
Leu <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (84)..(84) <223> OTHER INFORMATION: Xaa may be Met
or Ile <400> SEQUENCE: 182 Leu Pro Ala Pro Lys Asn Leu Val
Val Ser Glu Val Thr Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Xaa Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr
Thr 85 90 95 <210> SEQ ID NO 183 <211> LENGTH: 95
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: EGFR binding
FN3 domain consensus sequence <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (22)..(22) <223>
OTHER INFORMATION: Xaa may be Ala, Thr, Gly or Asp <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(23)..(23) <223> OTHER INFORMATION: Xaa may be Ala, Asp, Tyr
or Trp <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (24)..(24) <223> OTHER INFORMATION: Xaa
may be Pro, Asp or Asn <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (25)..(25) <223> OTHER
INFORMATION: Xaa may be Leu or absent <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (26)..(26)
<223> OTHER INFORMATION: Xaa may be Asp, His, Arg, Gly, Tyr
or Trp <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (27)..(27) <223> OTHER INFORMATION: Xaa
may be Gly, Asp or Ala <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (28)..(28) <223> OTHER
INFORMATION: Xaa may be Ala, Phe, Gly, His or Asp <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(29)..(29) <223> OTHER INFORMATION: Xaa may be Tyr, Phe or
Leu <400> SEQUENCE: 183 Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Xaa Xaa
Xaa Xaa Xaa Xaa Xaa Xaa Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln
Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu 35 40 45 Thr Val Pro
Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly
Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Gly Ser Tyr Val 65 70
75 80 Phe Glu His Asp Val Met Leu Pro Leu Ser Ala Glu Phe Thr Thr
85 90 95 <210> SEQ ID NO 184 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: c-Met binding
FN3 domain C strand and CD loop consensus sequence <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(4)..(4) <223> OTHER INFORMATION: Xaa is Trp, Phe or Val
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is Asp, Phe
or Leu <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (10)..(10) <223> OTHER INFORMATION: Xaa
is Val, Phe or Leu <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (11)..(11) <223> OTHER
INFORMATION: Xaa is Val, Leu or Thr <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (12)..(12)
<223> OTHER INFORMATION: Xaa is Val, Arg, Gly, Leu, Thr or
Ser <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (13)..(13) <223> OTHER INFORMATION: Xaa is Gly,
Ser, Ala, Thr or Lys <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (15)..(15) <223> OTHER
INFORMATION: Xaa is Glu or Asp <400> SEQUENCE: 184 Asp Ser
Phe Xaa Ile Arg Tyr Xaa Glu Xaa Xaa Xaa Xaa Gly Xaa 1 5 10 15
<210> SEQ ID NO 185 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain F strand
and FG loop consensus sequence <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (4)..(4) <223> OTHER
INFORMATION: Xaa is Tyr, Trp, Ile, Val, Gly or Ala <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(6)..(6) <223> OTHER INFORMATION: Xaa is Asn, Thr, Qln or Gly
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is Leu, Met,
Asn or Ile <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (9)..(9) <223> OTHER INFORMATION: Xaa
is Gly or Ser <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (14)..(14) <223> OTHER INFORMATION: Xaa
is Ser, Leu, Gly, Tyr, Thr, Arg, His or Lys <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is Ile, Val or Leu <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is Val, Thr, His,
Ile, Pro, Tyr or Leu <400> SEQUENCE: 185 Thr Glu Tyr Xaa Val
Xaa Ile Xaa Xaa Val Lys Gly Gly Xaa Xaa Ser 1 5 10 15 Xaa
<210> SEQ ID NO 186 <211> LENGTH: 89 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain consensus
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (32)..(32) <223> OTHER INFORMATION: Xaa
is Trp, Phe or Val <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (36)..(36) <223> OTHER
INFORMATION: Xaa is Asp, Phe or Leu <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (38)..(38)
<223> OTHER INFORMATION: Xaa is Val, Phe or Leu <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(39)..(39) <223> OTHER INFORMATION: Xaa is Val, Leu or Thr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Xaa is Val,
Arg, Gly, Leu, Thr or Ser <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (41)..(41) <223>
OTHER INFORMATION: Xaa is Gly, Ser, Ala, Thr or Lys <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(43)..(43) <223> OTHER INFORMATION: Xaa is Glu or Asp
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (68)..(68) <223> OTHER INFORMATION: Xaa is Tyr,
Trp, Ile, Val, Gly or Ala <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (70)..(70) <223>
OTHER INFORMATION: Xaa is Asn, Thr, Qln or Gly <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (72)..(72)
<223> OTHER INFORMATION: Xaa is Leu, Met, Asn or Ile
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (73)..(73) <223> OTHER INFORMATION: Xaa is Gly or
Ser <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (78)..(78) <223> OTHER INFORMATION: Xaa is Ser,
Leu, Gly, Tyr, Thr, Arg, His or Lys <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (79)..(79)
<223> OTHER INFORMATION: Xaa is Ile, Val or Leu <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(81)..(81) <223> OTHER INFORMATION: Xaa is Val, Thr, His,
Ile, Pro, Tyr or Leu <400> SEQUENCE: 186 Leu Pro Ala Pro Lys
Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu
Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Xaa 20 25 30 Ile
Arg Tyr Xaa Glu Xaa Xaa Xaa Xaa Gly Xaa Ala Ile Val Leu Thr 35 40
45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly
50 55 60 Thr Glu Tyr Xaa Val Xaa Ile Xaa Xaa Val Lys Gly Gly Xaa
Xaa Ser 65 70 75 80 Xaa Pro Leu Ser Ala Glu Phe Thr Thr 85
<210> SEQ ID NO 187 <211> LENGTH: 94 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR consensus FN3 domain of
bispecific EGFR/c-Met molecule <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (11)..(11) <223>
OTHER INFORMATION: Xaa is Glu, Asn or Arg <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (14)..(14)
<223> OTHER INFORMATION: Xaa is Glu or Pro <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is Leu or Ala
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (25)..(25) <223> OTHER INFORMATION: Xaa is His or
Trp <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (29)..(29) <223> OTHER INFORMATION: Xaa is Glu or
Asp <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (37)..(37) <223> OTHER INFORMATION: Xaa is Glu or
Pro <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (46)..(46) <223> OTHER INFORMATION: Xaa is Asn or
Val <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (73)..(73) <223> OTHER INFORMATION: Xaa is Gly or
Tyr <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (83)..(83) <223> OTHER INFORMATION: Xaa is Met or
Ile <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (91)..(91) <223> OTHER INFORMATION: Xaa is Glu or
Ile <400> SEQUENCE: 187 Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Xaa Val Thr Xaa Asp Ser 1 5 10 15 Xaa Arg Leu Ser Trp Asp Asp
Pro Xaa Ala Phe Tyr Xaa Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Xaa
Ser Glu Lys Val Gly Glu Ala Ile Xaa Leu Thr 35 40 45 Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr
Glu Tyr Thr Val Ser Ile Tyr Xaa Val His Asn Val Tyr Lys Asp 65 70
75 80 Thr Asn Xaa Arg Gly Leu Pro Leu Ser Ala Xaa Phe Thr Thr 85 90
<210> SEQ ID NO 188 <211> LENGTH: 89 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met consensus FN3 domain of
bispecific EGFR/c-Met molecule <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (11)..(11) <223>
OTHER INFORMATION: Xaa is Glu, Asn or Arg <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (14)..(14)
<223> OTHER INFORMATION: Xaa is Glu or Pro <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is Leu or Ala
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (37)..(37) <223> OTHER INFORMATION: Xaa is Glu or
Pro <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (39)..(39) <223> OTHER INFORMATION: Xaa is Val or
Leu <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Xaa is Gly or
Ser <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (41)..(41) <223> OTHER INFORMATION: Xaa is Ser or
Lys <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (43)..(43) <223> OTHER INFORMATION: Xaa is Glu or
Asp <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (46)..(46) <223> OTHER INFORMATION: Xaa is Asn or
Val <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (72)..(72) <223> OTHER INFORMATION: Xaa is Leu or
Met <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (73)..(73) <223> OTHER INFORMATION: Xaa is Gly or
Ser <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (78)..(78) <223> OTHER INFORMATION: Xaa is Ser or
Lys <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (86)..(86) <223> OTHER INFORMATION: Xaa is Glu or
Ile <400> SEQUENCE: 188 Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Xaa Val Thr Xaa Asp Ser 1 5 10 15 Xaa Arg Leu Ser Trp Thr Ala
Pro Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Xaa
Phe Xaa Xaa Xaa Gly Xaa Ala Ile Xaa Leu Thr 35 40 45 Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr
Glu Tyr Val Val Asn Ile Xaa Xaa Val Lys Gly Gly Xaa Ile Ser 65 70
75 80 Pro Pro Leu Ser Ala Xaa Phe Thr Thr 85 <210> SEQ ID NO
189 <211> LENGTH: 125 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 189 Gln Val Gln Leu
Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35
40 45 Ala Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser
Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Ile Thr Met Val Arg
Gly Val Met Lys Asp Tyr Phe 100 105 110 Asp Tyr Trp Gly Gln Gly Thr
Leu Val Thr Val Ser Ser 115 120 125 <210> SEQ ID NO 190
<211> LENGTH: 107 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 190 Ala Ile Gln Leu Thr Gln Ser
Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile
Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala 20 25 30 Leu Val Trp
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr
Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55
60 Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr
Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100
105 <210> SEQ ID NO 191 <211> LENGTH: 121 <212>
TYPE: PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE:
191 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Ser Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Lys Asp Gly Ser Glu Lys
Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Leu
Gly Trp Gly Trp Gly Trp Tyr Phe Asp Leu Trp Gly 100 105 110 Arg Gly
Thr Leu Val Thr Val Ser Ser 115 120 <210> SEQ ID NO 192
<211> LENGTH: 107 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 192 Glu Ile Val Leu Thr Gln Ser
Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu
Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr
Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55
60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp
Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100
105 <210> SEQ ID NO 193 <211> LENGTH: 119 <212>
TYPE: PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE:
193 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15 Ser Val Lys Val Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr
Ser Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly His Gly
Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Ala Tyr Asn Gly Tyr Thr
Asn Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr Met Thr Thr
Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu
Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Leu
Arg Gly Thr Asn Tyr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu
Val Thr Val Ser Ser 115 <210> SEQ ID NO 194 <211>
LENGTH: 107 <212> TYPE: PRT <213> ORGANISM: Homo
Sapiens <400> SEQUENCE: 194 Asp Ile Gln Met Thr Gln Ser Pro
Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr
Cys Arg Ala Ser Gln Gly Ile Ser Asn Trp 20 25 30 Leu Ala Trp Phe
Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala
Ala Ser Ser Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65
70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe
Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100
105 <210> SEQ ID NO 195 <211> LENGTH: 125 <212>
TYPE: PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE:
195 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Asp Tyr 20 25 30 Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg
Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Asp Asp Gly Ser Tyr Thr
Tyr Tyr Pro Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ala Lys Asn Asn Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu
Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly
Leu Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Gln 100 105 110 Asp Tyr
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210>
SEQ ID NO 196 <211> LENGTH: 106 <212> TYPE: PRT
<213> ORGANISM: Homo Sapiens <400> SEQUENCE: 196 Gln
Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 1 5 10
15 Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Leu Ser Ser Ala Leu Ala
20 25 30 Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
Tyr Asp 35 40 45 Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe
Ser Gly Ser Gly 50 55 60 Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
Ser Leu Gln Pro Glu Asp 65 70 75 80 Phe Ala Thr Tyr Tyr Cys Gln Gln
Phe Thr Ser Tyr Pro Gln Ile Thr 85 90 95 Phe Gly Gln Gly Thr Arg
Leu Glu Ile Lys 100 105 <210> SEQ ID NO 197 <211>
LENGTH: 457 <212> TYPE: PRT <213> ORGANISM: Homo
Sapiens <400> SEQUENCE: 197 Gln Val Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys
Gln Ala Ser Gly Tyr Arg Phe Ser Asn Phe 20 25 30 Val Ile His Trp
Val Arg Gln Ala Pro Gly Gln Arg Phe Glu Trp Met 35 40 45 Gly Trp
Ile Asn Pro Tyr Asn Gly Asn Lys Glu Phe Ser Ala Lys Phe 50 55 60
Gln Asp Arg Val Thr Phe Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 65
70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Val Gly Pro Tyr Ser Trp Asp Asp Ser Pro
Gln Asp Asn Tyr 100 105 110 Tyr Met Asp Val Trp Gly Lys Gly Thr Thr
Val Ile Val Ser Ser Ala 115 120 125 Ser Thr Lys Gly Pro Ser Val Phe
Pro Leu Ala Pro Ser Ser Lys Ser 130 135 140 Thr Ser Gly Gly Thr Ala
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 145 150 155 160 Pro Glu Pro
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 165 170 175 Val
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 180 185
190 Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
195 200 205 Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
Lys Arg 210 215 220 Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys
Pro Pro Cys Pro 225 230 235 240 Ala Pro Glu Leu Leu Gly Gly Pro Ser
Val Phe Leu Phe Pro Pro Lys 245 250 255 Pro Lys Asp Thr Leu Met Ile
Ser Arg Thr Pro Glu Val Thr Cys Val 260 265 270 Val Val Asp Val Ser
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 275 280 285 Val Asp Gly
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 290 295 300 Gln
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 305 310
315 320 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys 325 330 335 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala
Lys Gly Gln 340 345 350 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
Ser Arg Glu Glu Met 355 360 365 Thr Lys Asn Gln Val Ser Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro 370 375 380 Ser Asp Ile Ala Val Glu Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn 385 390 395 400 Tyr Lys Thr Thr
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Leu Leu 405 410 415 Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 420 425 430
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 435
440 445 Lys Ser Leu Ser Leu Ser Pro Gly Lys 450 455 <210> SEQ
ID NO 198 <211> LENGTH: 457 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 198 Gln Val Gln Leu
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val
Lys Val Ser Cys Gln Ala Ser Gly Tyr Arg Phe Ser Asn Phe 20 25 30
Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Phe Glu Trp Met 35
40 45 Gly Trp Ile Asn Pro Tyr Asn Gly Asn Lys Glu Phe Ser Ala Lys
Phe 50 55 60 Gln Asp Arg Val Thr Phe Thr Ala Asp Thr Ser Ala Asn
Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Ala Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Gly Pro Tyr Ser Trp Asp
Asp Ser Pro Gln Asp Asn Tyr 100 105 110 Tyr Met Asp Val Trp Gly Lys
Gly Thr Thr Val Ile Val Ser Ser Ala 115 120 125 Ser Thr Lys Gly Pro
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 130 135 140 Thr Ser Gly
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 145 150 155 160
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 165
170 175 Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
Leu 180 185 190 Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
Gln Thr Tyr 195 200 205 Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr
Lys Val Asp Lys Arg 210 215 220 Val Glu Pro Lys Ser Cys Asp Lys Thr
His Thr Cys Pro Pro Cys Pro 225 230 235 240 Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 245 250 255 Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 260 265 270 Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 275 280 285
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 290
295 300 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
His 305 310 315 320 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys 325 330 335 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly Gln 340 345 350 Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg Glu Glu Met 355 360 365 Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 370 375 380 Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 385 390 395 400 Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 405 410
415 Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
420 425 430 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr Gln 435 440 445 Lys Ser Leu Ser Leu Ser Pro Gly Lys 450 455
<210> SEQ ID NO 199 <211> LENGTH: 455 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 199
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5
10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr
Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val 35 40 45 Ala Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr
Tyr Gly Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Ile
Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe 100 105 110 Asp Tyr Trp
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 115 120 125 Lys
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 130 135
140 Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145 150 155 160 Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
Gly Val His 165 170 175 Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu
Tyr Ser Leu Ser Ser 180 185 190 Val Val Thr Val Pro Ser Ser Ser Leu
Gly Thr Gln Thr Tyr Ile Cys 195 200 205 Asn Val Asn His Lys Pro Ser
Asn Thr Lys Val Asp Lys Arg Val Glu 210 215 220 Pro Lys Ser Cys Asp
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 225 230 235 240 Glu Leu
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 245 250 255
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 260
265 270 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
Asp 275 280 285 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
Glu Gln Tyr 290 295 300 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
Val Leu His Gln Asp 305 310 315 320 Trp Leu Asn Gly Lys Glu Tyr Lys
Cys Lys Val Ser Asn Lys Ala Leu 325 330 335 Pro Ala Pro Ile Glu Lys
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 340 345 350 Glu Pro Gln Val
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 355 360 365 Asn Gln
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 370 375 380
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 385
390 395 400 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Leu Leu
Tyr Ser 405 410 415 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
Asn Val Phe Ser 420 425 430 Cys Ser Val Met His Glu Ala Leu His Asn
His Tyr Thr Gln Lys Ser 435 440 445 Leu Ser Leu Ser Pro Gly Lys 450
455 <210> SEQ ID NO 200 <211> LENGTH: 214 <212>
TYPE: PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE:
200 Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser
Ser Ala 20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro
Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val
Pro Ser Arg Phe Ser Gly 50 55 60 Ser Glu Ser Gly Thr Asp Phe Thr
Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr
Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 85 90 95 Thr Phe Gly Gly
Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser
Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130
135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly
Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys
210 <210> SEQ ID NO 201 <211> LENGTH: 449 <212>
TYPE: PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE:
201 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15 Ser Val Lys Val Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr
Ser Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly His Gly
Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Ala Tyr Asn Gly Tyr Thr
Asn Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr Met Thr Thr
Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu
Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Leu
Arg Gly Thr Asn Tyr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 115 120 125
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 130
135 140 Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
Trp 145 150 155 160 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
Pro Ala Val Leu 165 170 175 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
Val Val Thr Val Pro Ser 180 185 190 Ser Ser Leu Gly Thr Gln Thr Tyr
Ile Cys Asn Val Asn His Lys Pro 195 200 205 Ser Asn Thr Lys Val Asp
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 210 215 220 Thr His Thr Cys
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 225 230 235 240 Ser
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 245 250
255 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
260 265 270 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
His Asn 275 280 285 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr Arg Val 290 295 300 Val Ser Val Leu Thr Val Leu His Gln Asp
Trp Leu Asn Gly Lys Glu 305 310 315 320 Tyr Lys Cys Lys Val Ser Asn
Lys Ala Leu Pro Ala Pro Ile Glu Lys 325 330 335 Thr Ile Ser Lys Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 340 345 350 Leu Pro Pro
Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 355 360 365 Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 370 375
380 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385 390 395 400 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr
Val Asp Lys 405 410 415 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
Ser Val Met His Glu 420 425 430 Ala Leu His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser Pro Gly 435 440 445 Lys <210> SEQ ID NO
202 <211> LENGTH: 214 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 202 Asp Ile Gln Met
Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg
Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Trp 20 25 30
Leu Ala Trp Phe Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35
40 45 Tyr Ala Ala Ser Ser Leu Leu Ser Gly Val Pro Ser Arg Phe Ser
Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala
Asn Ser Phe Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu
Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro
Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val
Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln
Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165
170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val
Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> SEQ
ID NO 203 <211> LENGTH: 330 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 203 Ala Ser Thr Lys
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35
40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn
Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys
Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165
170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290
295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330
<210> SEQ ID NO 204 <211> LENGTH: 330 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 204
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5
10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro Lys
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135
140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260
265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
Leu 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 325 330 <210> SEQ ID NO 205 <211> LENGTH: 1368
<212> TYPE: DNA <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 205 caggtgcagc tggtcgagag cggcggaggg
gtggtgcagc ccggcagaag cctgaggctg 60 tcctgcgccg ccagcggctt
caccttcagc acctacggca tgcactgggt gcggcaggcc 120 ccaggcaagg
gcctggagtg ggtggccgtg atctgggacg acggcagcta caagtactac 180
ggcgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac
240 ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc
cagggacggc 300 atcaccatgg tgcggggcgt gatgaaggac tacttcgact
actggggcca gggcaccctg 360 gtgaccgtga gcagcgccag caccaagggc
ccaagcgtgt tccccctggc ccccagcagc 420 aagagcacca gcggcggcac
agccgccctg ggctgcctgg tgaaggacta cttccccgag 480 ccagtgaccg
tgtcctggaa ctctggcgcc ctgacctccg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc
600 ctgggcaccc agacctacat ctgcaacgtg aaccacaagc ccagcaacac
caaggtggac 660 aagagagtgg agcccaagag ctgcgacaag acccacacct
gccccccctg cccagcccca 720 gagctgctgg gcggacccag cgtgttcctg
ttccccccca agcccaagga caccctgatg 780 atcagcagga cccccgaggt
gacctgcgtg gtggtggacg tgagccacga ggacccagag 840 gtgaagttca
actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcccaga 900
gaggagcagt acaacagcac ctacagggtg gtgtccgtgc tgaccgtgct gcaccaggac
960 tggctgaacg gcaaggaata caagtgcaag gtctccaaca aggccctgcc
agcccccatc 1020 gaaaagacca tcagcaaggc caagggccag ccacgggagc
cccaggtgta caccctgccc 1080 cccagccggg aggagatgac caagaaccag
gtgtccctga cctgtctggt gaagggcttc 1140 taccccagcg acatcgccgt
ggagtgggag agcaacggcc agcccgagaa caactacaag 1200 accacccccc
cagtgctgga cagcgacggc agcttcctcc tgtacagcaa gctgaccgtg 1260
gacaagtcca ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg
1320 cacaaccact acacccagaa gtccctgagc ctgagccccg gcaaatga 1368
<210> SEQ ID NO 206 <211> LENGTH: 642 <212> TYPE:
DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 206
atccagctga cccagagccc cagcagcctg agcgccagcg tgggcgaccg ggtgaccatc
60 acctgccggg ccagccagga catcagcagc gccctggtct ggtatcagca
gaagcccggc 120 aaggccccca agctgctgat ctacgacgcc agctccctgg
aaagcggcgt gcccagccgg 180 ttcagcggca gcgagagcgg caccgacttc
accctgacca tcagcagcct gcagcccgag 240 gacttcgcca cctactactg
ccagcagttc aacagctacc ccctgacctt tggcggcgga 300 acaaaggtgg
agatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc 360
gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc
420 cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa
cagccaggag 480 agcgtcaccg agcaggacag caaggactcc acctacagcc
tgagcagcac cctgaccctg 540 tccaaggccg actacgagaa gcacaaggtg
tacgcctgcg aggtgaccca ccagggcctg 600 tccagccccg tgaccaagag
cttcaacagg ggcgagtgct ga 642 <210> SEQ ID NO 207 <211>
LENGTH: 1350 <212> TYPE: DNA <213> ORGANISM: Homo
Sapiens <400> SEQUENCE: 207 caggttcagc tggtgcagtc tggagctgag
gtgaagaagc ctggggcctc agtgaaggtc 60 tcctgcgaga cttctggtta
cacctttacc agctatggta tcagctgggt gcgacaggcc 120 cctggacacg
ggcttgagtg gatgggatgg atcagcgctt acaatggtta cacaaactat 180
gcacagaagc tccagggcag ggtcaccatg accacagaca catccacgag cacagcctac
240 atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc
gagagatctg 300 agaggaacta actactttga ctactggggc cagggaaccc
tggtcaccgt ctcctcagcc 360 tccaccaagg gcccaagcgt gttccctctg
gcccccagca gcaagagcac atctggcgga 420 acagccgccc tgggctgcct
ggtgaaagac tacttccccg agcccgtgac cgtgtcctgg 480 aactctggcg
ccctgaccag cggcgtgcac acctttccag ccgtgctgca gagcagcggc 540
ctgtacagcc tgtccagcgt ggtgaccgtg cccagcagct ccctgggcac ccagacctac
600 atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagcgggt
ggaacccaag 660 agctgcgaca agacccacac ctgtcccccc tgccctgccc
ctgaactgct gggcggaccc 720 tccgtgttcc tgttcccccc aaagcccaag
gacaccctga tgatcagccg gacccccgaa 780 gtgacctgcg tggtggtgga
cgtgtcccac gaggaccctg aagtgaagtt caattggtac 840 gtggacggcg
tggaagtgca caacgccaag accaagccca gagaggaaca gtacaacagc 900
acctaccggg tggtgtccgt gctgacagtg ctgcaccagg actggctgaa cggcaaagag
960 tacaagtgca aggtctccaa caaggccctg cctgctccca tcgagaaaac
catcagcaag 1020 gccaagggcc agccccgcga gcctcaggtg tacacactgc
ctcccagccg ggaagagatg 1080 accaagaacc aggtgtccct gacctgtctg
gtgaaaggct tctaccccag cgatatcgcc 1140 gtggaatggg agagcaacgg
acagcccgag aacaactaca agaccacccc ccctgtgctg 1200 gacagcgacg
gctccttctt cctgtactct cggctgaccg tggacaagag ccggtggcag 1260
cagggaaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag
1320 aagtccctga gcctgagccc cgggaagtga 1350 <210> SEQ ID NO
208 <211> LENGTH: 645 <212> TYPE: DNA <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 208 gacatccaga
tgacccagtc cccctcctcc gtgtccgcct ctgtgggcga cagagtgacc 60
atcacctgtc gggcctccca gggcatctcc aactggctgg cctggttcca gcacaagccc
120 ggcaaggccc ccaagctgct gatctacgcc gcctcctccc tgctgtccgg
cgtgccctcc 180 agattctccg gctctggctc cggcaccgac ttcaccctga
ccatctccag cctgcagccc 240 gaggacttcg ccacctacta ctgccagcag
gccaactcct tccccatcac cttcggccag 300 ggcacccggc tggaaatcaa
gcgtacggtg gccgctccca gcgtgttcat cttccccccc 360 agcgacgagc
agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac 420
ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag
480 gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag
caccctgacc 540 ctgtccaagg ccgactacga gaagcacaag gtgtacgcct
gcgaggtgac ccaccagggc 600 ctgtccagcc ccgtgaccaa gagcttcaac
aggggcgagt gctga 645 <210> SEQ ID NO 209 <211> LENGTH:
215 <212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 209 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr
Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Ser Cys Arg
Ser Ser His Ser Ile Arg Ser Arg 20 25 30 Arg Val Ala Trp Tyr Gln
His Lys Pro Gly Gln Ala Pro Arg Leu Val 35 40 45 Ile His Gly Val
Ser Asn Arg Ala Ser Gly Ile Ser Asp Arg Phe Ser 50 55 60 Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Val Glu 65 70 75 80
Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Val Tyr Gly Ala Ser Ser 85
90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Arg Lys Arg Thr Val
Ala 100 105 110 Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
Leu Lys Ser 115 120 125 Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
Phe Tyr Pro Arg Glu 130 135 140 Ala Lys Val Gln Trp Lys Val Asp Asn
Ala Leu Gln Ser Gly Asn Ser 145 150 155 160 Gln Glu Ser Val Thr Glu
Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 165 170 175 Ser Ser Thr Leu
Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 180 185 190 Tyr Ala
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 195 200 205
Ser Phe Asn Arg Gly Glu Cys 210 215 <210> SEQ ID NO 210
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 210 Thr Tyr Gly Met His 1 5
<210> SEQ ID NO 211 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 211
Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val Lys 1 5
10 15 Gly <210> SEQ ID NO 212 <211> LENGTH: 16
<212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 212 Asp Gly Ile Thr Met Val Arg Gly Val Met
Lys Asp Tyr Phe Asp Tyr 1 5 10 15 <210> SEQ ID NO 213
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 213 Arg Ala Ser Gln Asp Ile Ser
Ser Ala Leu Val 1 5 10 <210> SEQ ID NO 214 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 214 Asp Ala Ser Ser Leu Glu Ser 1 5
<210> SEQ ID NO 215 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 215
Gln Gln Phe Asn Ser Tyr Pro Leu Thr 1 5 <210> SEQ ID NO 216
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 216 Ser Tyr Gly Ile Ser 1 5
<210> SEQ ID NO 217 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 217
Trp Ile Ser Ala Tyr Asn Gly Tyr Thr Asn Tyr Ala Gln Lys Leu Gln 1 5
10 15 Gly <210> SEQ ID NO 218 <211> LENGTH: 10
<212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 218 Asp Leu Arg Gly Thr Asn Tyr Phe Asp Tyr 1
5 10 <210> SEQ ID NO 219 <211> LENGTH: 11 <212>
TYPE: PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE:
219 Arg Ala Ser Gln Gly Ile Ser Asn Trp Leu Ala 1 5 10 <210>
SEQ ID NO 220 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Homo Sapiens <400> SEQUENCE: 220 Ala
Ala Ser Ser Leu Leu Ser 1 5 <210> SEQ ID NO 221 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 221 Gln Gln Ala Asn Ser Phe Pro Ile Thr 1 5
<210> SEQ ID NO 222 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 222
Ser Tyr Trp Met Asn 1 5 <210> SEQ ID NO 223 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 223 Asn Ile Lys Lys Asp Gly Ser Glu Lys Tyr
Tyr Val Asp Ser Val Lys 1 5 10 15 Gly <210> SEQ ID NO 224
<211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 224 Asp Leu Gly Trp Gly Trp Gly
Trp Tyr Phe Asp Leu 1 5 10 <210> SEQ ID NO 225 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 225 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu
Ala 1 5 10 <210> SEQ ID NO 226 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 226 Asp Ala Ser Asn Arg Ala Thr 1 5
<210> SEQ ID NO 227 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 227
Gln Gln Arg Ser Asn Trp Pro Pro Thr 1 5 <210> SEQ ID NO 228
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 228 Asp Tyr Tyr Met Tyr 1 5
<210> SEQ ID NO 229 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 229
Thr Ile Ser Asp Asp Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 1 5
10 15 Gly <210> SEQ ID NO 230 <211> LENGTH: 16
<212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 230 Glu Gly Leu Tyr Tyr Tyr Gly Ser Gly Ser
Tyr Tyr Asn Gln Asp Tyr 1 5 10 15 <210> SEQ ID NO 231
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 231 Arg Ala Ser Gln Gly Leu Ser
Ser Ala Leu Ala 1 5 10 <210> SEQ ID NO 232 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 232 Asp Ala Ser Ser Leu Glu Ser 1 5
<210> SEQ ID NO 233 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 233
Gln Gln Phe Thr Ser Tyr Pro Gln Ile Thr 1 5 10 <210> SEQ ID
NO 234 <211> LENGTH: 451 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 234 Glu Val Gln Leu
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35
40 45 Ala Asn Ile Lys Lys Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser
Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Leu Gly Trp Gly Trp Gly
Trp Tyr Phe Asp Leu Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val
Ser Ser Ala Ser Thr Lys Gly Pro Ser 115 120 125 Val Phe Pro Leu Ala
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 130 135 140 Ala Leu Gly
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 145 150 155 160
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 165
170 175 Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
Val 180 185 190 Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
Val Asn His 195 200 205 Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val
Glu Pro Lys Ser Cys 210 215 220 Asp Lys Thr His Thr Cys Pro Pro Cys
Pro Ala Pro Glu Leu Leu Gly 225 230 235 240 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 245 250 255 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 260 265 270 Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 275 280 285
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 290
295 300 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
Gly 305 310 315 320 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 325 330 335 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 340 345 350 Tyr Thr Leu Pro Pro Ser Arg Glu
Glu Met Thr Lys Asn Gln Val Ser 355 360 365 Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 370 375 380 Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 385 390 395 400 Val
Leu Asp Ser Asp Gly Ser Phe Leu Leu Tyr Ser Lys Leu Thr Val 405 410
415 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
420 425 430 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser 435 440 445 Pro Gly Lys 450 <210> SEQ ID NO 235
<211> LENGTH: 214 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 235 Glu Ile Val Leu Thr Gln Ser
Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu
Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr
Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55
60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp
Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu
Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val
Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val
Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185
190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> SEQ ID NO 236
<211> LENGTH: 455 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 236 Glu Val Gln Leu Val Glu Ser
Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Lys Leu Ser
Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Tyr Met Tyr
Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 35 40 45 Ala
Thr Ile Ser Asp Asp Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 50 55
60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr
65 70 75 80 Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr
Tyr Cys 85 90 95 Ala Arg Glu Gly Leu Tyr Tyr Tyr Gly Ser Gly Ser
Tyr Tyr Asn Gln 100 105 110 Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser Ala Ser Thr 115 120 125 Lys Gly Pro Ser Val Phe Pro Leu
Ala Pro Ser Ser Lys Ser Thr Ser 130 135 140 Gly Gly Thr Ala Ala Leu
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 145 150 155 160 Pro Val Thr
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 165 170 175 Thr
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 180 185
190 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
195 200 205 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg
Val Glu 210 215 220 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
Cys Pro Ala Pro 225 230 235 240 Glu Leu Leu Gly Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro Lys 245 250 255 Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val Val 260 265 270 Asp Val Ser His Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 275 280 285 Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 290 295 300 Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 305 310
315 320 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
Leu 325 330 335 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro Arg 340 345 350 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Glu Glu Met Thr Lys 355 360 365 Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp 370 375 380 Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys 385 390 395 400 Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 405 410 415 Arg Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 420 425 430
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 435
440 445 Leu Ser Leu Ser Pro Gly Lys 450 455 <210> SEQ ID NO
237 <211> LENGTH: 213 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 237 Gln Leu Thr Gln
Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 1 5 10 15 Val Thr
Ile Thr Cys Arg Ala Ser Gln Gly Leu Ser Ser Ala Leu Ala 20 25 30
Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp 35
40 45 Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
Gly 50 55 60 Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro Glu Asp 65 70 75 80 Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser
Tyr Pro Gln Ile Thr 85 90 95 Phe Gly Gln Gly Thr Arg Leu Glu Ile
Lys Arg Thr Val Ala Ala Pro 100 105 110 Ser Val Phe Ile Phe Pro Pro
Ser Asp Glu Gln Leu Lys Ser Gly Thr 115 120 125 Ala Ser Val Val Cys
Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 130 135 140 Val Gln Trp
Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 145 150 155 160
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 165
170 175 Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
Ala 180 185 190 Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
Lys Ser Phe 195 200 205 Asn Arg Gly Glu Cys 210 <210> SEQ ID
NO 238 <211> LENGTH: 15 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 238 Pro Glu Phe Arg
Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe 1 5 10 15 <210>
SEQ ID NO 239 <211> LENGTH: 16 <212> TYPE: PRT
<213> ORGANISM: Homo Sapiens <400> SEQUENCE: 239 Phe
Ala Gln Ser Lys Pro Asp Ser Ala Glu Pro Met Asp Arg Ser Ala 1 5 10
15 <210> SEQ ID NO 240 <211> LENGTH: 16 <212>
TYPE: PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE:
240 Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser Leu Asn Asp Asp
1 5 10 15
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 240
<210> SEQ ID NO 1 <211> LENGTH: 89 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Tencon FN3 scaffold <400>
SEQUENCE: 1 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu
Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe
Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly
Glu Ala Ile Asn Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr
Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val Ser
Ile Tyr Gly Val Lys Gly Gly His Arg Ser 65 70 75 80 Asn Pro Leu Ser
Ala Glu Phe Thr Thr 85 <210> SEQ ID NO 2 <211> LENGTH:
58 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: primer
<400> SEQUENCE: 2 ggaaacagga tctaccatgc tgccggcgcc gaaaaacctg
gttgtttctg aagttacc 58 <210> SEQ ID NO 3 <211> LENGTH:
21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: primer
<400> SEQUENCE: 3 aacaccgtag atagaaacgg t 21 <210> SEQ
ID NO 4 <211> LENGTH: 131 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: primer <400> SEQUENCE: 4 cggcggttag
aacgcggcta caattaatac ataaccccat ccccctgttg acaattaatc 60
atcggctcgt ataatgtgtg gaattgtgag cggataacaa tttcacacag gaaacaggat
120 ctaccatgct g 131 <210> SEQ ID NO 5 <211> LENGTH: 21
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: primer
<400> SEQUENCE: 5 cggcggttag aacgcggcta c 21 <210> SEQ
ID NO 6 <211> LENGTH: 66 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: primer <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (26)..(27) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (29)..(30)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(32)..(33) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (35)..(36) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (38)..(39) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (41)..(42) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (44)..(45) <223>
OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 6
ggtggtgaat tccgcagaca gcggsnnsnn snnsnnsnns nnsnnaacac cgtagataga
60 aacggt 66 <210> SEQ ID NO 7 <211> LENGTH: 69
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: primer
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (26)..(27) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (29)..(30) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (32)..(33) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (35)..(36) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (38)..(39)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(41)..(42) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (44)..(45) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (47)..(48) <223> OTHER INFORMATION: n
is a, c, g, or t <400> SEQUENCE: 7 ggtggtgaat tccgcagaca
gcggsnnsnn snnsnnsnns nnsnnsnnaa caccgtagat 60 agaaacggt 69
<210> SEQ ID NO 8 <211> LENGTH: 72 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: primer <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (26)..(27)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(29)..(30) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (32)..(33) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (35)..(36) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (38)..(39) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (41)..(42) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (44)..(45)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(47)..(48) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (50)..(51) <223> OTHER INFORMATION: n is a, c, g,
or t <400> SEQUENCE: 8 ggtggtgaat tccgcagaca gcggsnnsnn
snnsnnsnns nnsnnsnnsn naacaccgta 60 gatagaaacg gt 72 <210>
SEQ ID NO 9 <211> LENGTH: 75 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: primer <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (26)..(27)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(29)..(30) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (32)..(33) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (35)..(36) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (38)..(39) <223> OTHER
INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (41)..(42) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (44)..(45) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (47)..(48) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (50)..(51) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (53)..(54)
<223> OTHER INFORMATION: n is a, c, g, or t <400>
SEQUENCE: 9 ggtggtgaat tccgcagaca gcggsnnsnn snnsnnsnns nnsnnsnnsn
nsnnaacacc 60 gtagatagaa acggt 75 <210> SEQ ID NO 10
<211> LENGTH: 80 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: primer <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (28)..(29) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (31)..(32) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (34)..(35)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(37)..(38) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (40)..(41) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (43)..(44) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (46)..(47) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (49)..(50) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (52)..(53)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(55)..(56) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (58)..(59) <223> OTHER INFORMATION: n is a, c, g,
or t <400> SEQUENCE: 10 rmggtggtga attccgcaga cagcggsnns
nnsnnsnnsn nsnnsnnsnn snnsnnsnna 60 acaccgtaga tagaaacggt 80
<210> SEQ ID NO 11 <211> LENGTH: 81 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: primer <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (26)..(27)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(29)..(30) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (32)..(33) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (35)..(36) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (38)..(39) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (41)..(42) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (44)..(45)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(47)..(48) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (50)..(51) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (53)..(54) <223> OTHER INFORMATION: n
is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (56)..(57) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (59)..(60) <223>
OTHER INFORMATION: n is a, c, g, or t <400> SEQUENCE: 11
ggtggtgaat tccgcagaca gcggsnnsnn snnsnnsnns nnsnnsnnsn nsnnsnnsnn
60 aacaccgtag atagaaacgg t 81 <210> SEQ ID NO 12 <211>
LENGTH: 81 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: primer
<400> SEQUENCE: 12 aagatcagtt gcggccgcta gactagaacc
gctgccatgg tgatggtgat ggtgaccgcc 60 ggtggtgaat tccgcagaca g 81
<210> SEQ ID NO 13 <211> LENGTH: 30 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: primer <400> SEQUENCE: 13
cggcggttag aacgcggcta caattaatac 30 <210> SEQ ID NO 14
<211> LENGTH: 22 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: primer <400> SEQUENCE: 14 catgattacg ccaagctcag
aa 22 <210> SEQ ID NO 15 <211> LENGTH: 65 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: primer <400>
SEQUENCE: 15 gagccgccgc caccggttta atggtgatgg tgatggtgac caccggtggt
gaattccgca 60 gacag 65 <210> SEQ ID NO 16 <211> LENGTH:
37 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: primer
<400> SEQUENCE: 16 aagaaggaga accggtatgc tgccggcgcc gaaaaac
37 <210> SEQ ID NO 17 <211> LENGTH: 89 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: primer <400>
SEQUENCE: 17 tttgggaagc ttctaggtct cggcggtcac catcaccatc accatggcag
cggttctagt 60 ctagcggccc caactgatct tcaccaaac 89 <210> SEQ ID
NO 18 <211> LENGTH: 94 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 18
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5
10 15 Leu Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe
Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Asn Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Glu Phe Thr Thr
85 90 <210> SEQ ID NO 19 <211> LENGTH: 94 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 19 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Thr Tyr Asp
Arg Asp Gly Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90
<210> SEQ ID NO 20 <211> LENGTH: 94 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 20 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Gly Tyr Asn Gly Asp His
Phe Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Asn Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90 <210> SEQ
ID NO 21 <211> LENGTH: 94 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 21
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5
10 15 Leu Arg Leu Ser Trp Asp Asp Pro Arg Gly Phe Tyr Glu Ser Phe
Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Asn Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Glu Phe Thr Thr 85 90 <210> SEQ ID NO 22
<211> LENGTH: 94 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 22 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5 10
15 Leu Arg Leu Ser Trp Thr Trp Pro Tyr Ala Asp Leu Asp Ser Phe Leu
20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val
His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met Arg Gly Leu Pro Leu
Ser Ala Glu Phe Thr Thr 85 90 <210> SEQ ID NO 23 <211>
LENGTH: 94 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: EGFR
binding FN3 domain <400> SEQUENCE: 23 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser
Trp Gly Tyr Asn Gly Asp His Phe Asp Ser Phe Leu 20 25 30 Ile Gln
Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys
Asp 65 70 75 80 Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr
Thr 85 90 <210> SEQ ID NO 24 <211> LENGTH: 95
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: EGFR binding
FN3 domain <400> SEQUENCE: 24 Leu Pro Ala Pro Lys Asn Leu Val
Val Ser Glu Val Thr Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Asp
Tyr Asp Leu Gly Val Tyr Phe Asp Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr
Thr 85 90 95 <210> SEQ ID NO 25 <211> LENGTH: 94
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: EGFR binding
FN3 domain <400> SEQUENCE: 25 Leu Pro Ala Pro Lys Asn Leu Val
Val Ser Glu Val Thr Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Asp
Asp Pro Trp Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln
Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 35 40 45 Val Pro
Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60
Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65
70 75 80 Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85
90 <210> SEQ ID NO 26 <211> LENGTH: 94 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 26 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val Leu Gly Ser Tyr Val Phe 65 70 75 80
Glu His Asp Val Met Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90
<210> SEQ ID NO 27 <211> LENGTH: 94 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 27 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr 85 90
<210> SEQ ID NO 28 <211> LENGTH: 94 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 28 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val Leu Gly Ser Tyr Val Phe 65 70 75 80 Glu His Asp
Val Met Leu Pro Leu Ser Ala Ile Phe Thr Thr 85 90 <210> SEQ
ID NO 29 <211> LENGTH: 94 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: EGFR binding FN3 domain <400> SEQUENCE: 29
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5
10 15 Leu Arg Leu Ser Trp Thr Trp Pro Tyr Ala Asp Leu Asp Ser Phe
Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Asn Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met Arg Gly Leu Pro
Leu Ser Ala Glu Phe Thr Thr 85 90 <210> SEQ ID NO 30
<211> LENGTH: 37 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: primer <400> SEQUENCE: 30 Ala Ala Gly Ala Ala
Gly Gly Ala Gly Ala Ala Cys Cys Gly Gly Thr 1 5 10 15 Ala Thr Gly
Cys Thr Gly Cys Cys Gly Gly Cys Gly Cys Cys Gly Ala 20 25 30 Ala
Ala Ala Ala Cys 35 <210> SEQ ID NO 31 <211> LENGTH: 65
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: primer
<400> SEQUENCE: 31 Gly Ala Gly Cys Cys Gly Cys Cys Gly Cys
Cys Ala Cys Cys Gly Gly 1 5 10 15 Thr Thr Thr Ala Ala Thr Gly Gly
Thr Gly Ala Thr Gly Gly Thr Gly 20 25 30 Ala Thr Gly Gly Thr Gly
Ala Cys Cys Ala Cys Cys Gly Gly Thr Gly 35 40 45 Gly Thr Gly Ala
Ala Gly Ala Thr Cys Gly Cys Ala Gly Ala Cys Ala 50 55 60 Gly 65
<210> SEQ ID NO 32 <211> LENGTH: 89 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain <400>
SEQUENCE: 32 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Asp Glu Val Val Val Gly
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Tyr Val
Asn Ile Leu Gly Val Lys Gly Gly Ser Ile Ser 65 70 75 80 Val Pro Leu
Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 33 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: c-Met
binding FN3 domain <400> SEQUENCE: 33 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Phe 20 25 30 Ile Arg
Tyr Asp Glu Phe Leu Arg Ser Gly Glu Ala Ile Val Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Trp Val Thr Ile Leu Gly Val Lys Gly Gly Leu Val
Ser 65 70 75 80 Thr Pro Leu Ser Ala Ile Phe Thr Thr 85 <210>
SEQ ID NO 34 <211> LENGTH: 89 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain <400>
SEQUENCE: 34 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Ile Val
Asn Ile Met Gly Val Lys Gly Gly Ser Ile Ser 65 70 75 80 His Pro Leu
Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 35 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: c-Met
binding FN3 domain <400> SEQUENCE: 35 Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile Val Leu Thr 35 40 45
Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50
55 60 Thr Glu Tyr Val Val Asn Ile Leu Gly Val Lys Gly Gly Gly Leu
Ser 65 70 75 80 Val Pro Leu Ser Ala Ile Phe Thr Thr 85 <210>
SEQ ID NO 36 <211> LENGTH: 89 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain <400>
SEQUENCE: 36 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Val 20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val
Gln Ile Leu Gly Val Lys Gly Gly Tyr Ile Ser 65 70 75 80 Ile Pro Leu
Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 37 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: c-Met
binding FN3 domain
<400> SEQUENCE: 37 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Leu Glu Phe
Leu Leu Gly Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Val Val Gln Ile Met Gly Val Lys Gly Gly Thr Val Ser 65 70 75 80
Pro Pro Leu Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 38
<211> LENGTH: 89 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: c-Met binding FN3 domain <400> SEQUENCE: 38 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10
15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp
20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile Val
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val Gly Ile Asn Gly Val
Lys Gly Gly Tyr Ile Ser 65 70 75 80 Tyr Pro Leu Ser Ala Ile Phe Thr
Thr 85 <210> SEQ ID NO 39 <211> LENGTH: 89 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: c-Met binding FN3 domain
<400> SEQUENCE: 39 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe
Leu Gly Ser Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Asp Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Gly Val Thr Ile Asn Gly Val Lys Gly Gly Arg Val Ser 65 70 75 80
Thr Pro Leu Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 40
<211> LENGTH: 89 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: c-Met binding FN3 domain <400> SEQUENCE: 40 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10
15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp
20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile Val
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val Gln Ile Ile Gly Val
Lys Gly Gly His Ile Ser 65 70 75 80 Leu Pro Leu Ser Ala Ile Phe Thr
Thr 85 <210> SEQ ID NO 41 <211> LENGTH: 89 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: c-Met binding FN3 domain
<400> SEQUENCE: 41 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe
Leu Gly Ser Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Val Val Asn Ile Met Gly Val Lys Gly Gly Lys Ile Ser 65 70 75 80
Pro Pro Leu Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 42
<211> LENGTH: 89 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: c-Met binding FN3 domain <400> SEQUENCE: 42 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10
15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp
20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile Val
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Ala Val Asn Ile Met Gly Val
Lys Gly Gly Arg Val Ser 65 70 75 80 Val Pro Leu Ser Ala Ile Phe Thr
Thr 85 <210> SEQ ID NO 43 <211> LENGTH: 89 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: c-Met binding FN3 domain
<400> SEQUENCE: 43 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe
Leu Gly Ser Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Val Val Gln Ile Leu Gly Val Lys Gly Gly Ser Ile Ser 65 70 75 80
Val Pro Leu Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 44
<211> LENGTH: 89 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: c-Met binding FN3 domain <400> SEQUENCE: 44 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10
15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp
20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile Val
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val Asn Ile Met Gly Val
Lys Gly Gly Ser Ile Ser 65 70 75 80 Tyr Pro Leu Ser Ala Ile Phe Thr
Thr 85 <210> SEQ ID NO 45 <211> LENGTH: 89 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: c-Met binding FN3 domain
<400> SEQUENCE: 45 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe
Leu Gly Ser Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Val Val Gln Ile Leu Gly Val Lys Gly Gly Tyr Ile Ser 65 70 75 80
Ile Pro Leu Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 46
<211> LENGTH: 89 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: c-Met binding FN3 domain
<400> SEQUENCE: 46 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe
Leu Gly Ser Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Val Val Gln Ile Met Gly Val Lys Gly Gly Thr Val Ser 65 70 75 80
Pro Pro Leu Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 47
<211> LENGTH: 89 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: c-Met binding FN3 domain <400> SEQUENCE: 47 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10
15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp
20 25 30 Ile Arg Tyr Phe Glu Phe Thr Thr Ala Gly Glu Ala Ile Val
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val Asn Ile Met Gly Val
Lys Gly Gly Ser Ile Ser 65 70 75 80 Pro Pro Leu Ser Ala Ile Phe Thr
Thr 85 <210> SEQ ID NO 48 <211> LENGTH: 89 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: c-Met binding FN3 domain
<400> SEQUENCE: 48 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Leu
Leu Ser Thr Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Val Val Asn Ile Met Gly Val Lys Gly Gly Ser Ile Ser 65 70 75 80
Pro Pro Leu Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 49
<211> LENGTH: 89 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: c-Met binding FN3 domain <400> SEQUENCE: 49 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10
15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp
20 25 30 Ile Arg Tyr Phe Glu Phe Val Ser Lys Gly Glu Ala Ile Val
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val Asn Ile Met Gly Val
Lys Gly Gly Ser Ile Ser 65 70 75 80 Pro Pro Leu Ser Ala Ile Phe Thr
Thr 85 <210> SEQ ID NO 50 <211> LENGTH: 205 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: bispecific EGFR/cMet
binding molecule <400> SEQUENCE: 50 Met Leu Pro Ala Pro Lys
Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu
Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile
Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50
55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr
Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe
Thr Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly 100 105 110 Gly Gly Ser Met Leu Pro Ala Pro Lys
Asn Leu Val Val Ser Arg Val 115 120 125 Thr Glu Asp Ser Ala Arg Leu
Ser Trp Thr Ala Pro Asp Ala Ala Phe 130 135 140 Asp Ser Phe Trp Ile
Arg Tyr Asp Glu Val Val Val Gly Gly Glu Ala 145 150 155 160 Ile Val
Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 165 170 175
Leu Lys Pro Gly Thr Glu Tyr Tyr Val Asn Ile Leu Gly Val Lys Gly 180
185 190 Gly Ser Ile Ser Val Pro Leu Ser Ala Ile Phe Thr Thr 195 200
205 <210> SEQ ID NO 51 <211> LENGTH: 204 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: bispecific EGFR/cMet
binding molecule <400> SEQUENCE: 51 Met Leu Pro Ala Pro Lys
Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu
Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile
Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50
55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr
Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe
Thr Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly 100 105 110 Gly Gly Ser Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val Thr 115 120 125 Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe Asp 130 135 140 Ser Phe Trp Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile 145 150 155 160 Val Leu
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 165 170 175
Lys Pro Gly Thr Glu Tyr Val Val Asn Ile Met Gly Val Lys Gly Gly 180
185 190 Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr Thr 195 200
<210> SEQ ID NO 52 <211> LENGTH: 205 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 52 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 100 105 110 Gly Gly Ser Met Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val 115 120 125 Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe 130 135 140 Asp Ser Phe Trp Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala 145 150 155 160 Ile Val Leu
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 165 170 175 Leu
Lys Pro Gly Thr Glu Tyr Val Val Gln Ile Ile Gly Val Lys Gly 180 185
190 Gly His Ile Ser Leu Pro Leu Ser Ala Ile Phe Thr Thr 195 200
205
<210> SEQ ID NO 53 <211> LENGTH: 205 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 53 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 100 105 110 Gly Gly Ser Met Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val 115 120 125 Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe 130 135 140 Asp Ser Phe Phe Ile Arg
Tyr Asp Glu Phe Leu Arg Ser Gly Glu Ala 145 150 155 160 Ile Val Leu
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 165 170 175 Leu
Lys Pro Gly Thr Glu Tyr Trp Val Thr Ile Leu Gly Val Lys Gly 180 185
190 Gly Leu Val Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 195 200 205
<210> SEQ ID NO 54 <211> LENGTH: 205 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 54 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Ala Asp Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 100 105 110 Gly Gly Ser Met Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val 115 120 125 Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe 130 135 140 Asp Ser Phe Trp Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala 145 150 155 160 Ile Val Leu
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 165 170 175 Leu
Lys Pro Gly Thr Glu Tyr Val Val Asn Ile Met Gly Val Lys Gly 180 185
190 Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr Thr 195 200 205
<210> SEQ ID NO 55 <211> LENGTH: 205 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 55 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Ala Asp Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 100 105 110 Gly Gly Ser Met Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val 115 120 125 Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe 130 135 140 Asp Ser Phe Trp Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala 145 150 155 160 Ile Val Leu
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 165 170 175 Leu
Lys Pro Gly Thr Glu Tyr Val Val Gln Ile Ile Gly Val Lys Gly 180 185
190 Gly His Ile Ser Leu Pro Leu Ser Ala Ile Phe Thr Thr 195 200 205
<210> SEQ ID NO 56 <211> LENGTH: 205 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 56 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Ala Asp Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Gly 85 90 95 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly 100 105 110 Gly Gly Ser Met Leu Pro Ala Pro Lys Asn
Leu Val Val Ser Arg Val 115 120 125 Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala Pro Asp Ala Ala Phe 130 135 140 Asp Ser Phe Trp Ile Arg
Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala 145 150 155 160 Ile Val Leu
Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 165 170 175 Leu
Lys Pro Gly Thr Glu Tyr Val Val Gln Ile Ile Gly Val Lys Gly 180 185
190 Gly His Ile Ser Leu Pro Leu Ser Ala Ile Phe Thr Thr 195 200 205
<210> SEQ ID NO 57 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 57 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Met
Gly Val Lys Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr <210> SEQ ID NO 58 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: bispecific
EGFR/cMet binding molecule <400> SEQUENCE: 58 Met Leu Pro Ala
Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15
Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20
25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val
Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val
His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu
Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro
Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val
Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala
Ala Phe Asp Ser Phe Trp Ile Arg Tyr Asp Glu Val Val 130 135 140 Val
Gly Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150
155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Tyr Val Asn
Ile 165 170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Val Pro Leu Ser
Ala Ile Phe 180 185 190 Thr Thr <210> SEQ ID NO 59
<211> LENGTH: 195 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: bispecific EGFR/cMet binding molecule <400>
SEQUENCE: 59 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Ala Asp Pro His Gly
Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Met Leu Pro Ala Pro Lys Asn 100 105
110 Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr
115 120 125 Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe
Glu Phe 130 135 140 Leu Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro
Gly Ser Glu Arg 145 150 155 160 Ser Tyr Asp Leu Thr Gly Leu Lys Pro
Gly Thr Glu Tyr Val Val Asn 165 170 175 Ile Met Gly Val Lys Gly Gly
Lys Ile Ser Pro Pro Leu Ser Ala Ile 180 185 190 Phe Thr Thr 195
<210> SEQ ID NO 60 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 60 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Ala Asp Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Asp Glu Val Val 130 135 140 Val Gly Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Tyr Val Asn Ile 165 170 175 Leu
Gly Val Lys Gly Gly Ser Ile Ser Val Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr <210> SEQ ID NO 61 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: bispecific
EGFR/cMet binding molecule <400> SEQUENCE: 61 Met Leu Pro Ala
Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala
Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30
Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35
40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys
Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn
Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala
Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro
Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu
Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe
Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly
Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160
Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165
170 175 Leu Gly Val Lys Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile
Phe 180 185 190 Thr Thr <210> SEQ ID NO 62 <211>
LENGTH: 194 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
bispecific EGFR/cMet binding molecule <400> SEQUENCE: 62 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro
Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala
Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg
Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp
Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140
Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145
150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val
Asn Ile 165 170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu
Ser Ala Ile Phe 180 185 190 Thr Thr <210> SEQ ID NO 63
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: bispecific EGFR/cMet binding molecule <400>
SEQUENCE: 63 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr
Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu
Phe Val 130 135 140 Ser Lys Gly Asp Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Gly Val Lys Gly Gly Ser
Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr <210>
SEQ ID NO 64 <211> LENGTH: 194 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 64 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu
Ser Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr <210> SEQ ID NO 65 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: bispecific
EGFR/cMet binding molecule <400> SEQUENCE: 65 Met Leu Pro Ala
Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala
Arg Leu Ser Trp Asp Asp Pro His Ala Phe Tyr Glu Ser Phe 20 25 30
Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35
40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys
Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn
Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala
Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro
Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu
Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe
Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly
Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160
Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165
170 175 Leu Gly Val Lys Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile
Phe 180 185 190 Thr Thr <210> SEQ ID NO 66 <211>
LENGTH: 194 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
bispecific EGFR/cMet binding molecule <400> SEQUENCE: 66 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Ala Arg Leu Ser Trp Asp Asp Pro His Ala Phe Tyr Glu Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro
Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala
Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg
Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp
Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140
Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145
150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val
Asn Ile 165 170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu
Ser Ala Ile Phe 180 185 190 Thr Thr <210> SEQ ID NO 67
<211> LENGTH: 194 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: bispecific EGFR/cMet binding molecule <400>
SEQUENCE: 67 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro His Ala
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu
Phe Val 130 135 140 Ser Lys Gly Asp Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Gly Val Lys Gly Gly Ser
Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr <210>
SEQ ID NO 68 <211> LENGTH: 194 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 68 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro His Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu
Ser Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr <210> SEQ ID NO 69 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: bispecific
EGFR/cMet binding molecule
<400> SEQUENCE: 69 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Ala Asp
Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu
Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr
Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80
Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85
90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn
Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg
Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile Val Leu Thr
Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu
Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Gly Val Lys
Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr
<210> SEQ ID NO 70 <211> LENGTH: 194 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: bispecific EGFR/cMet binding
molecule <400> SEQUENCE: 70 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Ala Asp Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140 Gly Ser Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu
Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr <210> SEQ ID NO 71 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: bispecific
EGFR/cMet binding molecule <400> SEQUENCE: 71 Met Leu Pro Ala
Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala
Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe 20 25 30
Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35
40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys
Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn
Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala
Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro
Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu
Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe
Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140 Ser Lys Gly
Asp Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160
Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165
170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile
Phe 180 185 190 Thr Thr <210> SEQ ID NO 72 <211>
LENGTH: 194 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
bispecific EGFR/cMet binding molecule <400> SEQUENCE: 72 Met
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10
15 Ser Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe
20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile
Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr
Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly
Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro
Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala
Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg
Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp
Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140
Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145
150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val
Asn Ile 165 170 175 Leu Ser Val Lys Gly Gly Ser Ile Ser Pro Pro Leu
Ser Ala Ile Phe 180 185 190 Thr Thr <210> SEQ ID NO 73
<211> LENGTH: 1210 <212> TYPE: PRT <213>
ORGANISM: HOMO SAPIENS <400> SEQUENCE: 73 Met Arg Pro Ser Gly
Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 1 5 10 15 Ala Leu Cys
Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 20 25 30 Gly
Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 35 40
45 Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn
50 55 60 Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe
Leu Lys 65 70 75 80 Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala
Leu Asn Thr Val 85 90 95 Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile
Ile Arg Gly Asn Met Tyr 100 105 110 Tyr Glu Asn Ser Tyr Ala Leu Ala
Val Leu Ser Asn Tyr Asp Ala Asn 115 120 125 Lys Thr Gly Leu Lys Glu
Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 130 135 140 His Gly Ala Val
Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 145 150 155 160 Ser
Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 165 170
175 Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro
180 185 190 Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn
Cys Gln 195 200 205 Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser
Gly Arg Cys Arg 210 215 220 Gly Lys Ser Pro Ser Asp Cys Cys His Asn
Gln Cys Ala Ala Gly Cys 225 230 235 240 Thr Gly Pro Arg Glu Ser Asp
Cys Leu Val Cys Arg Lys Phe Arg Asp 245 250 255 Glu Ala Thr Cys Lys
Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 260 265 270 Thr Thr Tyr
Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 275 280 285 Ala
Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 290 295
300 Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu
305 310 315 320 Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys
Arg Lys Val 325 330 335 Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp
Ser Leu Ser Ile Asn 340 345 350 Ala Thr Asn Ile Lys His Phe Lys Asn
Cys Thr Ser Ile Ser Gly Asp
355 360 365 Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr
His Thr 370 375 380 Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys
Thr Val Lys Glu 385 390 395 400 Ile Thr Gly Phe Leu Leu Ile Gln Ala
Trp Pro Glu Asn Arg Thr Asp 405 410 415 Leu His Ala Phe Glu Asn Leu
Glu Ile Ile Arg Gly Arg Thr Lys Gln 420 425 430 His Gly Gln Phe Ser
Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 435 440 445 Gly Leu Arg
Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 450 455 460 Gly
Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 465 470
475 480 Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly
Glu 485 490 495 Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu
Cys Ser Pro 500 505 510 Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys
Val Ser Cys Arg Asn 515 520 525 Val Ser Arg Gly Arg Glu Cys Val Asp
Lys Cys Asn Leu Leu Glu Gly 530 535 540 Glu Pro Arg Glu Phe Val Glu
Asn Ser Glu Cys Ile Gln Cys His Pro 545 550 555 560 Glu Cys Leu Pro
Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 565 570 575 Asp Asn
Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 580 585 590
Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 595
600 605 Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn
Cys 610 615 620 Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro
Thr Asn Gly 625 630 635 640 Pro Lys Ile Pro Ser Ile Ala Thr Gly Met
Val Gly Ala Leu Leu Leu 645 650 655 Leu Leu Val Val Ala Leu Gly Ile
Gly Leu Phe Met Arg Arg Arg His 660 665 670 Ile Val Arg Lys Arg Thr
Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 675 680 685 Val Glu Pro Leu
Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 690 695 700 Arg Ile
Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 705 710 715
720 Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu
725 730 735 Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala
Thr Ser 740 745 750 Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr
Val Met Ala Ser 755 760 765 Val Asp Asn Pro His Val Cys Arg Leu Leu
Gly Ile Cys Leu Thr Ser 770 775 780 Thr Val Gln Leu Ile Thr Gln Leu
Met Pro Phe Gly Cys Leu Leu Asp 785 790 795 800 Tyr Val Arg Glu His
Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 805 810 815 Trp Cys Val
Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 820 825 830 Leu
Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 835 840
845 Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala
850 855 860 Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile
Lys Trp 865 870 875 880 Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr
Thr His Gln Ser Asp 885 890 895 Val Trp Ser Tyr Gly Val Thr Val Trp
Glu Leu Met Thr Phe Gly Ser 900 905 910 Lys Pro Tyr Asp Gly Ile Pro
Ala Ser Glu Ile Ser Ser Ile Leu Glu 915 920 925 Lys Gly Glu Arg Leu
Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 930 935 940 Met Ile Met
Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 945 950 955 960
Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 965
970 975 Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser
Pro 980 985 990 Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu
Asp Met Asp 995 1000 1005 Asp Val Val Asp Ala Asp Glu Tyr Leu Ile
Pro Gln Gln Gly Phe 1010 1015 1020 Phe Ser Ser Pro Ser Thr Ser Arg
Thr Pro Leu Leu Ser Ser Leu 1025 1030 1035 Ser Ala Thr Ser Asn Asn
Ser Thr Val Ala Cys Ile Asp Arg Asn 1040 1045 1050 Gly Leu Gln Ser
Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg 1055 1060 1065 Tyr Ser
Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp 1070 1075 1080
Asp Thr Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro 1085
1090 1095 Lys Arg Pro Ala Gly Ser Val Gln Asn Pro Val Tyr His Asn
Gln 1100 1105 1110 Pro Leu Asn Pro Ala Pro Ser Arg Asp Pro His Tyr
Gln Asp Pro 1115 1120 1125 His Ser Thr Ala Val Gly Asn Pro Glu Tyr
Leu Asn Thr Val Gln 1130 1135 1140 Pro Thr Cys Val Asn Ser Thr Phe
Asp Ser Pro Ala His Trp Ala 1145 1150 1155 Gln Lys Gly Ser His Gln
Ile Ser Leu Asp Asn Pro Asp Tyr Gln 1160 1165 1170 Gln Asp Phe Phe
Pro Lys Glu Ala Lys Pro Asn Gly Ile Phe Lys 1175 1180 1185 Gly Ser
Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val Ala Pro Gln 1190 1195 1200
Ser Ser Glu Phe Ile Gly Ala 1205 1210 <210> SEQ ID NO 74
<211> LENGTH: 53 <212> TYPE: PRT <213> ORGANISM:
HOMO SAPIENS <400> SEQUENCE: 74 Asn Ser Asp Ser Glu Cys Pro
Leu Ser His Asp Gly Tyr Cys Leu His 1 5 10 15 Asp Gly Val Cys Met
Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 20 25 30 Cys Val Val
Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 35 40 45 Trp
Trp Glu Leu Arg 50 <210> SEQ ID NO 75 <211> LENGTH:
2201 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 75 Met Gly Ala Met Thr Gln Leu Leu Ala Gly
Val Phe Leu Ala Phe Leu 1 5 10 15 Ala Leu Ala Thr Glu Gly Gly Val
Leu Lys Lys Val Ile Arg His Lys 20 25 30 Arg Gln Ser Gly Val Asn
Ala Thr Leu Pro Glu Glu Asn Gln Pro Val 35 40 45 Val Phe Asn His
Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys 50 55 60 Ser Val
Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro 65 70 75 80
Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 85
90 95 Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys
Gly 100 105 110 Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg
Leu Glu Glu 115 120 125 Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln
Cys Thr Ala Gly Ala 130 135 140 Gly Cys Cys Leu Gln Pro Ala Thr Gly
Arg Leu Asp Thr Arg Pro Phe 145 150 155 160 Cys Ser Gly Arg Gly Asn
Phe Ser Thr Glu Gly Cys Gly Cys Val Cys 165 170 175 Glu Pro Gly Trp
Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly 180 185 190 Asn Cys
His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp 195 200 205
Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp 210
215 220 Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe
Glu 225 230 235 240 Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys
Pro Val Pro Cys 245 250 255 Ser Glu Glu His Gly Thr Cys Val Asp Gly
Leu Cys Val Cys His Asp 260 265 270 Gly Phe Ala Gly Asp Asp Cys Asn
Lys Pro Leu Cys Leu Asn Asn Cys 275 280 285 Tyr Asn Arg Gly Arg Cys
Val Glu Asn Glu Cys Val Cys Asp Glu Gly 290 295 300 Phe Thr Gly Glu
Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 305 310 315 320
Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 325
330 335 Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His
Thr 340 345 350 Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu
Gly Phe Ala 355 360 365 Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala
Asp Cys His Asn Arg 370 375 380 Gly Arg Cys Val Asp Gly Arg Cys Glu
Cys Asp Asp Gly Phe Thr Gly 385 390 395 400 Ala Asp Cys Gly Glu Leu
Lys Cys Pro Asn Gly Cys Ser Gly His Gly 405 410 415 Arg Cys Val Asn
Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 420 425 430 Asp Cys
Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg 435 440 445
Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp 450
455 460 Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg
Cys 465 470 475 480 Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr
Gly Glu Asp Cys 485 490 495 Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser
Asn Arg Gly Leu Cys Val 500 505 510 Asp Gly Gln Cys Val Cys Glu Asp
Gly Phe Thr Gly Pro Asp Cys Ala 515 520 525 Glu Leu Ser Cys Pro Asn
Asp Cys His Gly Gln Gly Arg Cys Val Asn 530 535 540 Gly Gln Cys Val
Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu 545 550 555 560 Gln
Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly 565 570
575 Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His
580 585 590 Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser
Gly Arg 595 600 605 Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys
Ser Glu Val Ser 610 615 620 Pro Pro Lys Asp Leu Val Val Thr Glu Val
Thr Glu Glu Thr Val Asn 625 630 635 640 Leu Ala Trp Asp Asn Glu Met
Arg Val Thr Glu Tyr Leu Val Val Tyr 645 650 655 Thr Pro Thr His Glu
Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly 660 665 670 Asp Gln Thr
Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 675 680 685 Phe
Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 690 695
700 Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe
705 710 715 720 Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp
Pro Leu Asp 725 730 735 Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg
Asn Met Asn Lys Glu 740 745 750 Asp Glu Gly Glu Ile Thr Lys Ser Leu
Arg Arg Pro Glu Thr Ser Tyr 755 760 765 Arg Gln Thr Gly Leu Ala Pro
Gly Gln Glu Tyr Glu Ile Ser Leu His 770 775 780 Ile Val Lys Asn Asn
Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr 785 790 795 800 Thr Arg
Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp 805 810 815
Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly 820
825 830 Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr
Thr 835 840 845 Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly
Asn Leu Lys 850 855 860 Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser
Arg Arg Gly Asp Met 865 870 875 880 Ser Ser Asn Pro Ala Lys Glu Thr
Phe Thr Thr Gly Leu Asp Ala Pro 885 890 895 Arg Asn Leu Arg Arg Val
Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu 900 905 910 Trp Arg Asn Gly
Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 915 920 925 Pro Ile
Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln 930 935 940
Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 945
950 955 960 Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser
Asn Pro 965 970 975 Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro
Lys Asp Leu Gln 980 985 990 Val Ser Glu Thr Ala Glu Thr Ser Leu Thr
Leu Leu Trp Lys Thr Pro 995 1000 1005 Leu Ala Lys Phe Asp Arg Tyr
Arg Leu Asn Tyr Ser Leu Pro Thr 1010 1015 1020 Gly Gln Trp Val Gly
Val Gln Leu Pro Arg Asn Thr Thr Ser Tyr 1025 1030 1035 Val Leu Arg
Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val Leu Leu 1040 1045 1050 Thr
Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val Lys 1055 1060
1065 Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr
1070 1075 1080 Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala
Ala Asp 1085 1090 1095 Gln Ala Tyr Glu His Phe Ile Ile Gln Val Gln
Glu Ala Asn Lys 1100 1105 1110 Val Glu Ala Ala Arg Asn Leu Thr Val
Pro Gly Ser Leu Arg Ala 1115 1120 1125 Val Asp Ile Pro Gly Leu Lys
Ala Ala Thr Pro Tyr Thr Val Ser 1130 1135 1140 Ile Tyr Gly Val Ile
Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala 1145 1150 1155 Glu Ala Ser
Thr Gly Glu Thr Pro Asn Leu Gly Glu Val Val Val 1160 1165 1170 Ala
Glu Val Gly Trp Asp Ala Leu Lys Leu Asn Trp Thr Ala Pro 1175 1180
1185 Glu Gly Ala Tyr Glu Tyr Phe Phe Ile Gln Val Gln Glu Ala Asp
1190 1195 1200 Thr Val Glu Ala Ala Gln Asn Leu Thr Val Pro Gly Gly
Leu Arg 1205 1210 1215 Ser Thr Asp Leu Pro Gly Leu Lys Ala Ala Thr
His Tyr Thr Ile 1220 1225 1230 Thr Ile Arg Gly Val Thr Gln Asp Phe
Ser Thr Thr Pro Leu Ser 1235 1240 1245 Val Glu Val Leu Thr Glu Glu
Val Pro Asp Met Gly Asn Leu Thr 1250 1255 1260 Val Thr Glu Val Ser
Trp Asp Ala Leu Arg Leu Asn Trp Thr Thr 1265 1270 1275 Pro Asp Gly
Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln Glu Ala 1280 1285 1290 Asp
Gln Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser Leu 1295 1300
1305 Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr
1310 1315 1320 Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg
Pro Leu 1325 1330 1335 Ala Val Glu Val Val Thr Glu Asp Leu Pro Gln
Leu Gly Asp Leu 1340 1345 1350 Ala Val Ser Glu Val Gly Trp Asp Gly
Leu Arg Leu Asn Trp Thr 1355 1360 1365 Ala Ala Asp Asn Ala Tyr Glu
His Phe Val Ile Gln Val Gln Glu 1370 1375 1380 Val Asn Lys Val Glu
Ala Ala Gln Asn Leu Thr Leu Pro Gly Ser 1385 1390 1395 Leu Arg Ala
Val Asp Ile Pro Gly Leu Glu Ala Ala Thr Pro Tyr 1400 1405 1410 Arg
Val Ser Ile Tyr Gly Val Ile Arg Gly Tyr Arg Thr Pro Val 1415 1420
1425 Leu Ser Ala Glu Ala Ser Thr Ala Lys Glu Pro Glu Ile Gly Asn
1430 1435 1440 Leu Asn Val Ser Asp Ile Thr Pro Glu Ser Phe Asn Leu
Ser Trp 1445 1450 1455 Met Ala Thr Asp Gly Ile Phe Glu Thr Phe Thr
Ile Glu Ile Ile 1460 1465 1470 Asp Ser Asn Arg Leu Leu Glu Thr Val
Glu Tyr Asn Ile Ser Gly 1475 1480 1485 Ala Glu Arg Thr Ala His Ile
Ser Gly Leu Pro Pro Ser Thr Asp 1490 1495 1500 Phe Ile Val Tyr Leu
Ser Gly Leu Ala Pro Ser Ile Arg Thr Lys 1505 1510 1515 Thr Ile Ser
Ala Thr Ala Thr Thr Glu Ala Leu Pro Leu Leu Glu 1520 1525 1530 Asn
Leu Thr Ile Ser Asp Ile Asn Pro Tyr Gly Phe Thr Val Ser 1535 1540
1545 Trp Met Ala Ser Glu Asn Ala Phe Asp Ser Phe Leu Val Thr Val
1550 1555 1560 Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu Phe Thr
Leu Ser 1565 1570 1575 Gly Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu
Ile Thr Gly Ile 1580 1585 1590 Gly Tyr Glu Val Met Val Ser Gly Phe
Thr Gln Gly His Gln Thr 1595 1600 1605 Lys Pro Leu Arg Ala Glu Ile
Val Thr Glu Ala Glu Pro Glu Val 1610 1615 1620
Asp Asn Leu Leu Val Ser Asp Ala Thr Pro Asp Gly Phe Arg Leu 1625
1630 1635 Ser Trp Thr Ala Asp Glu Gly Val Phe Asp Asn Phe Val Leu
Lys 1640 1645 1650 Ile Arg Asp Thr Lys Lys Gln Ser Glu Pro Leu Glu
Ile Thr Leu 1655 1660 1665 Leu Ala Pro Glu Arg Thr Arg Asp Ile Thr
Gly Leu Arg Glu Ala 1670 1675 1680 Thr Glu Tyr Glu Ile Glu Leu Tyr
Gly Ile Ser Lys Gly Arg Arg 1685 1690 1695 Ser Gln Thr Val Ser Ala
Ile Ala Thr Thr Ala Met Gly Ser Pro 1700 1705 1710 Lys Glu Val Ile
Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val 1715 1720 1725 Ser Trp
Arg Ala Pro Thr Ala Gln Val Glu Ser Phe Arg Ile Thr 1730 1735 1740
Tyr Val Pro Ile Thr Gly Gly Thr Pro Ser Met Val Thr Val Asp 1745
1750 1755 Gly Thr Lys Thr Gln Thr Arg Leu Val Lys Leu Ile Pro Gly
Val 1760 1765 1770 Glu Tyr Leu Val Ser Ile Ile Ala Met Lys Gly Phe
Glu Glu Ser 1775 1780 1785 Glu Pro Val Ser Gly Ser Phe Thr Thr Ala
Leu Asp Gly Pro Ser 1790 1795 1800 Gly Leu Val Thr Ala Asn Ile Thr
Asp Ser Glu Ala Leu Ala Arg 1805 1810 1815 Trp Gln Pro Ala Ile Ala
Thr Val Asp Ser Tyr Val Ile Ser Tyr 1820 1825 1830 Thr Gly Glu Lys
Val Pro Glu Ile Thr Arg Thr Val Ser Gly Asn 1835 1840 1845 Thr Val
Glu Tyr Ala Leu Thr Asp Leu Glu Pro Ala Thr Glu Tyr 1850 1855 1860
Thr Leu Arg Ile Phe Ala Glu Lys Gly Pro Gln Lys Ser Ser Thr 1865
1870 1875 Ile Thr Ala Lys Phe Thr Thr Asp Leu Asp Ser Pro Arg Asp
Leu 1880 1885 1890 Thr Ala Thr Glu Val Gln Ser Glu Thr Ala Leu Leu
Thr Trp Arg 1895 1900 1905 Pro Pro Arg Ala Ser Val Thr Gly Tyr Leu
Leu Val Tyr Glu Ser 1910 1915 1920 Val Asp Gly Thr Val Lys Glu Val
Ile Val Gly Pro Asp Thr Thr 1925 1930 1935 Ser Tyr Ser Leu Ala Asp
Leu Ser Pro Ser Thr His Tyr Thr Ala 1940 1945 1950 Lys Ile Gln Ala
Leu Asn Gly Pro Leu Arg Ser Asn Met Ile Gln 1955 1960 1965 Thr Ile
Phe Thr Thr Ile Gly Leu Leu Tyr Pro Phe Pro Lys Asp 1970 1975 1980
Cys Ser Gln Ala Met Leu Asn Gly Asp Thr Thr Ser Gly Leu Tyr 1985
1990 1995 Thr Ile Tyr Leu Asn Gly Asp Lys Ala Glu Ala Leu Glu Val
Phe 2000 2005 2010 Cys Asp Met Thr Ser Asp Gly Gly Gly Trp Ile Val
Phe Leu Arg 2015 2020 2025 Arg Lys Asn Gly Arg Glu Asn Phe Tyr Gln
Asn Trp Lys Ala Tyr 2030 2035 2040 Ala Ala Gly Phe Gly Asp Arg Arg
Glu Glu Phe Trp Leu Gly Leu 2045 2050 2055 Asp Asn Leu Asn Lys Ile
Thr Ala Gln Gly Gln Tyr Glu Leu Arg 2060 2065 2070 Val Asp Leu Arg
Asp His Gly Glu Thr Ala Phe Ala Val Tyr Asp 2075 2080 2085 Lys Phe
Ser Val Gly Asp Ala Lys Thr Arg Tyr Lys Leu Lys Val 2090 2095 2100
Glu Gly Tyr Ser Gly Thr Ala Gly Asp Ser Met Ala Tyr His Asn 2105
2110 2115 Gly Arg Ser Phe Ser Thr Phe Asp Lys Asp Thr Asp Ser Ala
Ile 2120 2125 2130 Thr Asn Cys Ala Leu Ser Tyr Lys Gly Ala Phe Trp
Tyr Arg Asn 2135 2140 2145 Cys His Arg Val Asn Leu Met Gly Arg Tyr
Gly Asp Asn Asn His 2150 2155 2160 Ser Gln Gly Val Asn Trp Phe His
Trp Lys Gly His Glu His Ser 2165 2170 2175 Ile Gln Phe Ala Glu Met
Lys Leu Arg Pro Ser Asn Phe Arg Asn 2180 2185 2190 Leu Glu Gly Arg
Arg Lys Arg Ala 2195 2200 <210> SEQ ID NO 76 <211>
LENGTH: 89 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: Fibcon
FN3 domain <400> SEQUENCE: 76 Leu Asp Ala Pro Thr Asp Leu Gln
Val Thr Asn Val Thr Asp Thr Ser 1 5 10 15 Ile Thr Val Ser Trp Thr
Pro Pro Ser Ala Thr Ile Thr Gly Tyr Arg 20 25 30 Ile Thr Tyr Thr
Pro Ser Asn Gly Pro Gly Glu Pro Lys Glu Leu Thr 35 40 45 Val Pro
Pro Ser Ser Thr Ser Val Thr Ile Thr Gly Leu Thr Pro Gly 50 55 60
Val Glu Tyr Val Val Ser Leu Tyr Ala Leu Lys Asp Asn Gln Glu Ser 65
70 75 80 Pro Pro Leu Val Gly Thr Gln Thr Thr 85 <210> SEQ ID
NO 77 <211> LENGTH: 94 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 77 Val Ser Asp Val Pro
Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 1 5 10 15 Ser Leu Leu
Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 20 25 30 Arg
Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 35 40
45 Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro
50 55 60 Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg
Gly Asp 65 70 75 80 Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr
Arg Thr 85 90 <210> SEQ ID NO 78 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: linker
<400> SEQUENCE: 78 Gly Ser Gly Ser 1 <210> SEQ ID NO 79
<211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: linker <400> SEQUENCE: 79 Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly
Ser Gly Gly Gly Gly Ser 20 25 <210> SEQ ID NO 80 <211>
LENGTH: 4 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: linker
<400> SEQUENCE: 80 Ala Pro Ala Pro 1 <210> SEQ ID NO 81
<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: linker <400> SEQUENCE: 81 Ala Pro Ala Pro Ala
Pro Ala Pro Ala Pro 1 5 10 <210> SEQ ID NO 82 <211>
LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: linker
<400> SEQUENCE: 82 Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
Ala Pro Ala Pro Ala Pro 1 5 10 15 Ala Pro Ala Pro 20 <210>
SEQ ID NO 83 <211> LENGTH: 40 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: linker
<400> SEQUENCE: 83 Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
Ala Pro Ala Pro Ala Pro 1 5 10 15 Ala Pro Ala Pro Ala Pro Ala Pro
Ala Pro Ala Pro Ala Pro Ala Pro 20 25 30 Ala Pro Ala Pro Ala Pro
Ala Pro 35 40 <210> SEQ ID NO 84 <211> LENGTH: 29
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: linker
<400> SEQUENCE: 84 Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala
Lys Glu Ala Ala Ala Lys 1 5 10 15 Glu Ala Ala Ala Lys Glu Ala Ala
Ala Lys Ala Ala Ala 20 25 <210> SEQ ID NO 85 <211>
LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: tencon
BC loop <400> SEQUENCE: 85 Thr Ala Pro Asp Ala Ala Phe Asp 1
5 <210> SEQ ID NO 86 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: tencon FG loop <400> SEQUENCE:
86 Lys Gly Gly His Arg Ser Asn 1 5 <210> SEQ ID NO 87
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain BC loop <400> SEQUENCE:
87 Ala Asp Pro His Gly Phe Tyr Asp 1 5 <210> SEQ ID NO 88
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain BC loop <400> SEQUENCE:
88 Thr Tyr Asp Arg Asp Gly Tyr Asp 1 5 <210> SEQ ID NO 89
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain BC loop <400> SEQUENCE:
89 Trp Asp Pro Phe Ser Phe Tyr Asp 1 5 <210> SEQ ID NO 90
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain BC loop <400> SEQUENCE:
90 Asp Asp Pro Arg Gly Phe Tyr Glu 1 5 <210> SEQ ID NO 91
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain BC loop <400> SEQUENCE:
91 Thr Trp Pro Tyr Ala Asp Leu Asp 1 5 <210> SEQ ID NO 92
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain BC loop <400> SEQUENCE:
92 Gly Tyr Asn Gly Asp His Phe Asp 1 5 <210> SEQ ID NO 93
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain BC loop <400> SEQUENCE:
93 Asp Tyr Asp Leu Gly Val Tyr Asp 1 5 <210> SEQ ID NO 94
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain BC loop <400> SEQUENCE:
94 Asp Asp Pro Trp Asp Phe Tyr Glu 1 5 <210> SEQ ID NO 95
<211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain FG loop <400> SEQUENCE:
95 His Asn Val Tyr Lys Asp Thr Asn Met Arg Gly Leu 1 5 10
<210> SEQ ID NO 96 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain FG loop
<400> SEQUENCE: 96 Leu Gly Ser Tyr Val Phe Glu His Asp Val
Met 1 5 10 <210> SEQ ID NO 97 <211> LENGTH: 285
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: EGFR binding
FN3 domain from ECB97; P54AR4-83V22 <400> SEQUENCE: 97
atgttgccag cgccgaagaa cctggtagtt agcgaggtta ctgaggacag cgcgcgtctg
60 agctgggacg atccgtgggc gttctacgag agctttctga tccagtatca
agagagcgag 120 aaagtcggtg aagcgattgt gctgaccgtc ccgggctccg
agcgttccta cgacctgacc 180 ggtttgaagc cgggtaccga gtatacggtg
agcatctacg gtgttcacaa tgtctataag 240 gacactaata tccgcggtct
gcctctgagc gccattttca ccacc 285 <210> SEQ ID NO 98
<211> LENGTH: 285 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain from ECB15; P54AR4-83V2
<400> SEQUENCE: 98 atgctgccag cccctaagaa tctggtcgtg
agcgaagtaa ccgaggacag cgcccgcctg 60 agctgggacg acccgtgggc
gttctatgag tctttcctga ttcagtatca agaaagcgaa 120 aaagttggcg
aagcgatcgt cctgaccgtc ccgggtagcg agcgctccta cgatctgacc 180
ggcctgaaac cgggtacgga gtacacggtg tccatttacg gtgttcacaa tgtgtataaa
240 gacaccaaca tgcgtggcct gccgctgtcg gcgattttca ccacc 285
<210> SEQ ID NO 99 <211> LENGTH: 89 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: tencon27 FN3 domain <400>
SEQUENCE: 99 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 65 70 75 80 Asn Pro Leu
Ser Ala Ile Phe Thr Thr
85 <210> SEQ ID NO 100 <211> LENGTH: 89 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: TCL14 library <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(32)..(32) <223> OTHER INFORMATION: Xaa is any amino acid
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (34)..(34) <223> OTHER INFORMATION: Xaa is any
amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (36)..(36) <223> OTHER INFORMATION: Xaa
is any amino acid <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (38)..(38) <223> OTHER
INFORMATION: Xaa is any amino acid <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (39)..(39) <223>
OTHER INFORMATION: Xaa is any amino acid <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (40)..(40)
<223> OTHER INFORMATION: Xaa is any amino acid <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(41)..(41) <223> OTHER INFORMATION: Xaa is any amino acid
<220> FEATURE: <221> NAME/KEY: MISC_FEATURE <222>
LOCATION: (68)..(68) <223> OTHER INFORMATION: Xaa is any
amino acid <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (70)..(70) <223> OTHER INFORMATION: Xaa
is any amino acid <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (72)..(72) <223> OTHER
INFORMATION: Xaa is any amino acid <220> FEATURE: <221>
NAME/KEY: MISC_FEATURE <222> LOCATION: (78)..(78) <223>
OTHER INFORMATION: Xaa is any amino acid <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (79)..(79)
<223> OTHER INFORMATION: Xaa is any amino acid <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(81)..(81) <223> OTHER INFORMATION: Xaa is any amino acid
<400> SEQUENCE: 100 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp Ser Phe Xaa 20 25 30 Ile Xaa Tyr Xaa Glu Xaa
Xaa Xaa Xaa Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Gly Xaa Xaa Ser 65 70 75 80
Xaa Pro Leu Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 101
<211> LENGTH: 1408 <212> TYPE: PRT <213>
ORGANISM: HOMO SAPIENS <400> SEQUENCE: 101 Met Lys Ala Pro
Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 1 5 10 15 Thr Leu
Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 20 25 30
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 35
40 45 Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe
Leu 50 55 60 Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp
Leu Gln Lys 65 70 75 80 Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu
His Pro Asp Cys Phe 85 90 95 Pro Cys Gln Asp Cys Ser Ser Lys Ala
Asn Leu Ser Gly Gly Val Trp 100 105 110 Lys Asp Asn Ile Asn Met Ala
Leu Val Val Asp Thr Tyr Tyr Asp Asp 115 120 125 Gln Leu Ile Ser Cys
Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 130 135 140 Val Phe Pro
His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 145 150 155 160
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 165
170 175 Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg
Phe 180 185 190 Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr
Phe Pro Asp 195 200 205 His Pro Leu His Ser Ile Ser Val Arg Arg Leu
Lys Glu Thr Lys Asp 210 215 220 Gly Phe Met Phe Leu Thr Asp Gln Ser
Tyr Ile Asp Val Leu Pro Glu 225 230 235 240 Phe Arg Asp Ser Tyr Pro
Ile Lys Tyr Val His Ala Phe Glu Ser Asn 245 250 255 Asn Phe Ile Tyr
Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 260 265 270 Thr Phe
His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 275 280 285
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 290
295 300 Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala
Ala 305 310 315 320 Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln
Ile Gly Ala Ser 325 330 335 Leu Asn Asp Asp Ile Leu Phe Gly Val Phe
Ala Gln Ser Lys Pro Asp 340 345 350 Ser Ala Glu Pro Met Asp Arg Ser
Ala Met Cys Ala Phe Pro Ile Lys 355 360 365 Tyr Val Asn Asp Phe Phe
Asn Lys Ile Val Asn Lys Asn Asn Val Arg 370 375 380 Cys Leu Gln His
Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 385 390 395 400 Thr
Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 405 410
415 Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
420 425 430 Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile
Lys Gly 435 440 445 Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly
Arg Phe Met Gln 450 455 460 Val Val Val Ser Arg Ser Gly Pro Ser Thr
Pro His Val Asn Phe Leu 465 470 475 480 Leu Asp Ser His Pro Val Ser
Pro Glu Val Ile Val Glu His Thr Leu 485 490 495 Asn Gln Asn Gly Tyr
Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 500 505 510 Ile Pro Leu
Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 515 520 525 Cys
Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 530 535
540 Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545 550 555 560 Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala
Pro Leu Glu 565 570 575 Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp
Phe Gly Phe Arg Arg 580 585 590 Asn Asn Lys Phe Asp Leu Lys Lys Thr
Arg Val Leu Leu Gly Asn Glu 595 600 605 Ser Cys Thr Leu Thr Leu Ser
Glu Ser Thr Met Asn Thr Leu Lys Cys 610 615 620 Thr Val Gly Pro Ala
Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 625 630 635 640 Ser Asn
Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 645 650 655
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 660
665 670 Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser
Arg 675 680 685 His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser
Val Ser Asn 690 695 700 Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr
Ile Ser Thr Glu Phe 705 710 715 720 Ala Val Lys Leu Lys Ile Asp Leu
Ala Asn Arg Glu Thr Ser Ile Phe 725 730 735 Ser Tyr Arg Glu Asp Pro
Ile Val Tyr Glu Ile His Pro Thr Lys Ser 740 745 750 Phe Ile Ser Thr
Trp Trp Lys Glu Pro Leu Asn Ile Val Ser Phe Leu 755 760 765 Phe Cys
Phe Ala Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn 770 775 780
Leu Asn Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala 785
790 795 800 Gly Arg Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser
Glu Ile 805 810 815 Ile Cys Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn
Leu Gln Leu Pro 820 825 830 Leu Lys Thr Lys Ala Phe Phe Met Leu Asp
Gly Ile Leu Ser Lys Tyr 835 840 845 Phe Asp Leu Ile Tyr Val His Asn
Pro Val Phe Lys Pro Phe Glu Lys 850 855 860
Pro Val Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly 865
870 875 880 Asn Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys
Val Gly 885 890 895 Asn Lys Ser Cys Glu Asn Ile His Leu His Ser Glu
Ala Val Leu Cys 900 905 910 Thr Val Pro Asn Asp Leu Leu Lys Leu Asn
Ser Glu Leu Asn Ile Glu 915 920 925 Trp Lys Gln Ala Ile Ser Ser Thr
Val Leu Gly Lys Val Ile Val Gln 930 935 940 Pro Asp Gln Asn Phe Thr
Gly Leu Ile Ala Gly Val Val Ser Ile Ser 945 950 955 960 Thr Ala Leu
Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg 965 970 975 Lys
Gln Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg 980 985
990 Val His Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser
995 1000 1005 Pro Thr Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr
Arg Ala 1010 1015 1020 Thr Phe Pro Glu Asp Gln Phe Pro Asn Ser Ser
Gln Asn Gly Ser 1025 1030 1035 Cys Arg Gln Val Gln Tyr Pro Leu Thr
Asp Met Ser Pro Ile Leu 1040 1045 1050 Thr Ser Gly Asp Ser Asp Ile
Ser Ser Pro Leu Leu Gln Asn Thr 1055 1060 1065 Val His Ile Asp Leu
Ser Ala Leu Asn Pro Glu Leu Val Gln Ala 1070 1075 1080 Val Gln His
Val Val Ile Gly Pro Ser Ser Leu Ile Val His Phe 1085 1090 1095 Asn
Glu Val Ile Gly Arg Gly His Phe Gly Cys Val Tyr His Gly 1100 1105
1110 Thr Leu Leu Asp Asn Asp Gly Lys Lys Ile His Cys Ala Val Lys
1115 1120 1125 Ser Leu Asn Arg Ile Thr Asp Ile Gly Glu Val Ser Gln
Phe Leu 1130 1135 1140 Thr Glu Gly Ile Ile Met Lys Asp Phe Ser His
Pro Asn Val Leu 1145 1150 1155 Ser Leu Leu Gly Ile Cys Leu Arg Ser
Glu Gly Ser Pro Leu Val 1160 1165 1170 Val Leu Pro Tyr Met Lys His
Gly Asp Leu Arg Asn Phe Ile Arg 1175 1180 1185 Asn Glu Thr His Asn
Pro Thr Val Lys Asp Leu Ile Gly Phe Gly 1190 1195 1200 Leu Gln Val
Ala Lys Gly Met Lys Tyr Leu Ala Ser Lys Lys Phe 1205 1210 1215 Val
His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu Lys 1220 1225
1230 Phe Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr
1235 1240 1245 Asp Lys Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala
Lys Leu 1250 1255 1260 Pro Val Lys Trp Met Ala Leu Glu Ser Leu Gln
Thr Gln Lys Phe 1265 1270 1275 Thr Thr Lys Ser Asp Val Trp Ser Phe
Gly Val Leu Leu Trp Glu 1280 1285 1290 Leu Met Thr Arg Gly Ala Pro
Pro Tyr Pro Asp Val Asn Thr Phe 1295 1300 1305 Asp Ile Thr Val Tyr
Leu Leu Gln Gly Arg Arg Leu Leu Gln Pro 1310 1315 1320 Glu Tyr Cys
Pro Asp Pro Leu Tyr Glu Val Met Leu Lys Cys Trp 1325 1330 1335 His
Pro Lys Ala Glu Met Arg Pro Ser Phe Ser Glu Leu Val Ser 1340 1345
1350 Arg Ile Ser Ala Ile Phe Ser Thr Phe Ile Gly Glu His Tyr Val
1355 1360 1365 His Val Asn Ala Thr Tyr Val Asn Val Lys Cys Val Ala
Pro Tyr 1370 1375 1380 Pro Ser Leu Leu Ser Ser Glu Asp Asn Ala Asp
Asp Glu Val Asp 1385 1390 1395 Thr Arg Pro Ala Ser Phe Trp Glu Thr
Ser 1400 1405 <210> SEQ ID NO 102 <211> LENGTH: 697
<212> TYPE: PRT <213> ORGANISM: HOMO SAPIENS
<400> SEQUENCE: 102 Gln Arg Lys Arg Arg Asn Thr Ile His Glu
Phe Lys Lys Ser Ala Lys 1 5 10 15 Thr Thr Leu Ile Lys Ile Asp Pro
Ala Leu Lys Ile Lys Thr Lys Lys 20 25 30 Val Asn Thr Ala Asp Gln
Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly 35 40 45 Leu Pro Phe Thr
Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln 50 55 60 Cys Leu
Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu 65 70 75 80
Phe Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn 85
90 95 Cys Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile
Thr 100 105 110 Lys Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile
Pro His Glu 115 120 125 His Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys
Asp Leu Gln Glu Asn 130 135 140 Tyr Cys Arg Asn Pro Arg Gly Glu Glu
Gly Gly Pro Trp Cys Phe Thr 145 150 155 160 Ser Asn Pro Glu Val Arg
Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser 165 170 175 Glu Val Glu Cys
Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met 180 185 190 Asp His
Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr 195 200 205
Pro His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe 210
215 220 Asp Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp
Cys 225 230 235 240 Tyr Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys
Ala Ile Lys Thr 245 250 255 Cys Ala Asp Asn Thr Met Asn Asp Thr Asp
Val Pro Leu Glu Thr Thr 260 265 270 Glu Cys Ile Gln Gly Gln Gly Glu
Gly Tyr Arg Gly Thr Val Asn Thr 275 280 285 Ile Trp Asn Gly Ile Pro
Cys Gln Arg Trp Asp Ser Gln Tyr Pro His 290 295 300 Glu His Asp Met
Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu 305 310 315 320 Asn
Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr 325 330
335 Thr Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys
340 345 350 Asp Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys
Asn Tyr 355 360 365 Met Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr
Cys Ser Met Trp 370 375 380 Asp Lys Asn Met Glu Asp Leu His Arg His
Ile Phe Trp Glu Pro Asp 385 390 395 400 Ala Ser Lys Leu Asn Glu Asn
Tyr Cys Arg Asn Pro Asp Asp Asp Ala 405 410 415 His Gly Pro Trp Cys
Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr 420 425 430 Cys Pro Ile
Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn 435 440 445 Leu
Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val 450 455
460 Val Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu
465 470 475 480 Arg Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile
Lys Glu Ser 485 490 495 Trp Val Leu Thr Ala Arg Gln Cys Phe Pro Ser
Arg Asp Leu Lys Asp 500 505 510 Tyr Glu Ala Trp Leu Gly Ile His Asp
Val His Gly Arg Gly Asp Glu 515 520 525 Lys Cys Lys Gln Val Leu Asn
Val Ser Gln Leu Val Tyr Gly Pro Glu 530 535 540 Gly Ser Asp Leu Val
Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp 545 550 555 560 Asp Phe
Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro 565 570 575
Glu Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile 580
585 590 Asn Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly
Asn 595 600 605 Glu Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu
Asn Glu Ser 610 615 620 Glu Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser
Gly Pro Cys Glu Gly 625 630 635 640 Asp Tyr Gly Gly Pro Leu Val Cys
Glu Gln His Lys Met Arg Met Val 645 650 655 Leu Gly Val Ile Val Pro
Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro 660 665 670 Gly Ile Phe Val
Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile 675 680 685 Ile Leu
Thr Tyr Lys Val Pro Gln Ser 690 695 <210> SEQ ID NO 103
<211> LENGTH: 276 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: c-Met binding FN3 domain <400> SEQUENCE: 103
ctgccggctc cgaagaactt ggtggtgagc cgtgttaccg aagatagcgc acgcctgagc
60 tggacggcac cggatgcggc gttcgatagc ttctggattc gctattttga
gtttctgggt 120 agcggtgagg caattgttct gacggtgccg ggctctgaac
gctcctacga tttgaccggt 180 ctgaaaccgg gcaccgagta tgtggtgaac
attctgagcg ttaagggcgg tagcatcagc 240 ccaccgctga gcgcgatctt
cacgactggt ggttgc 276 <210> SEQ ID NO 104 <211> LENGTH:
267 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: c-Met binding
FN3 domain <400> SEQUENCE: 104 ctgccggcac cgaagaacct
ggttgtcagc cgtgtgaccg aggatagcgc acgtttgagc 60 tggaccgctc
cggatgcagc ctttgacagc ttctggattc gttactttga atttctgggt 120
agcggtgagg cgatcgttct gacggtgccg ggctctgaac gcagctatga tttgacgggc
180 ctgaagccgg gtactgagta cgtggttaac atcatgggcg ttaagggtgg
taaaatcagc 240 ccgccattgt ccgcgatctt taccacg 267 <210> SEQ ID
NO 105 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: linker <400> SEQUENCE: 105 Gly Gly Gly Gly
Ser 1 5 <210> SEQ ID NO 106 <211> LENGTH: 194
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Bispecific
EGFR/c-Met binding molecule <400> SEQUENCE: 106 Met Leu Pro
Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser
Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25
30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu
35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu
Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His
Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser
Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala
Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr
Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala
Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser
Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155
160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile
165 170 175 Leu Ser Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala
Ile Phe 180 185 190 Thr Thr <210> SEQ ID NO 107 <211>
LENGTH: 94 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: EGFR
binding FN3 domain <400> SEQUENCE: 107 Leu Pro Ala Pro Lys
Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu
Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe Leu 20 25 30 Ile
Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40
45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly
50 55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr
Lys Asp 65 70 75 80 Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe
Thr Thr 85 90 <210> SEQ ID NO 108 <211> LENGTH: 94
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: EGFR binding
FN3 domain <400> SEQUENCE: 108 Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55
60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp
65 70 75 80 Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr
85 90 <210> SEQ ID NO 109 <211> LENGTH: 94 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 109 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
His Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr 85 90
<210> SEQ ID NO 110 <211> LENGTH: 94 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 110 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe
Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Ile
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr 85 90 <210> SEQ
ID NO 111 <211> LENGTH: 89 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: c-Met binding FN3 domain <400> SEQUENCE:
111 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser
1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser
Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala
Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu
Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val Asn Ile Leu
Gly Val Lys Gly Gly Lys Ile Ser 65 70 75 80 Pro Pro Leu Ser Ala Ile
Phe Thr Thr 85 <210> SEQ ID NO 112 <211> LENGTH: 89
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: c-Met binding
FN3 domain <400> SEQUENCE: 112 Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15
Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 20
25 30 Ile Arg Tyr Phe Glu Phe Val Gly Ser Gly Glu Ala Ile Val Leu
Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu
Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val Asn Ile Leu Gly Val Lys
Gly Gly Ser Ile Ser 65 70 75 80 Pro Pro Leu Ser Ala Ile Phe Thr Thr
85 <210> SEQ ID NO 113 <211> LENGTH: 89 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: c-Met binding FN3 domain
<400> SEQUENCE: 113 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp Ser Phe Trp 20 25 30 Ile Arg Tyr Phe Glu Phe
Val Ser Lys Gly Asp Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Val Val Asn Ile Leu Gly Val Lys Gly Gly Ser Ile Ser 65 70 75 80
Pro Pro Leu Ser Ala Ile Phe Thr Thr 85 <210> SEQ ID NO 114
<211> LENGTH: 89 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: c-Met binding FN3 domain <400> SEQUENCE: 114 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10
15 Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp
20 25 30 Ile Arg Tyr Phe Glu Phe Leu Gly Ser Gly Glu Ala Ile Val
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val Asn Ile Leu Ser Val
Lys Gly Gly Ser Ile Ser 65 70 75 80 Pro Pro Leu Ser Ala Ile Phe Thr
Thr 85 <210> SEQ ID NO 115 <211> LENGTH: 591
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Bispecific
EGFR/c-Met binding molecule <400> SEQUENCE: 115 atgttgccag
cgccgaagaa cctggtagtt agcgaggtta ctgaggacag cgcgcgtctg 60
agctgggacg atccgtgggc gttctacgag agctttctga tccagtatca agagagcgag
120 aaagtcggtg aagcgattgt gctgaccgtc ccgggctccg agcgttccta
cgacctgacc 180 ggtttgaagc cgggtaccga gtatacggtg agcatctacg
gtgttcacaa tgtctataag 240 gacactaata tccgcggtct gcctctgagc
gccattttca ccaccgcacc ggcaccggct 300 ccggctcctg ccccgctgcc
ggctccgaag aacttggtgg tgagccgtgt taccgaagat 360 agcgcacgcc
tgagctggac ggcaccggat gcggcgttcg atagcttctg gattcgctat 420
tttgagtttc tgggtagcgg tgaggcaatt gttctgacgg tgccgggctc tgaacgctcc
480 tacgatttga ccggtctgaa accgggcacc gagtatgtgg tgaacattct
gagcgttaag 540 ggcggtagca tcagcccacc gctgagcgcg atcttcacga
ctggtggttg c 591 <210> SEQ ID NO 116 <211> LENGTH: 582
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Bispecific
EGFR/c-Met binding molecule <400> SEQUENCE: 116 atgctgccag
cccctaagaa tctggtcgtg agcgaagtaa ccgaggacag cgcccgcctg 60
agctgggacg acccgtgggc gttctatgag tctttcctga ttcagtatca agaaagcgaa
120 aaagttggcg aagcgatcgt cctgaccgtc ccgggtagcg agcgctccta
cgatctgacc 180 ggcctgaaac cgggtacgga gtacacggtg tccatttacg
gtgttcacaa tgtgtataaa 240 gacaccaaca tgcgtggcct gccgctgtcg
gcgattttca ccaccgcgcc tgcgccagcg 300 cctgcaccgg ctccgctgcc
ggcaccgaag aacctggttg tcagccgtgt gaccgaggat 360 agcgcacgtt
tgagctggac cgctccggat gcagcctttg acagcttctg gattcgttac 420
tttgaatttc tgggtagcgg tgaggcgatc gttctgacgg tgccgggctc tgaacgcagc
480 tatgatttga cgggcctgaa gccgggtact gagtacgtgg ttaacatcat
gggcgttaag 540 ggtggtaaaa tcagcccgcc attgtccgcg atctttacca cg 582
<210> SEQ ID NO 117 <211> LENGTH: 51 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: albumin binding domain <400>
SEQUENCE: 117 Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys
Ala Ile Glu 1 5 10 15 Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr
Tyr Phe Asp Leu Ile 20 25 30 Asn Lys Ala Lys Thr Val Glu Gly Val
Asn Ala Leu Lys Asp Glu Ile 35 40 45 Leu Lys Ala 50 <210> SEQ
ID NO 118 <211> LENGTH: 250 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding molecule
<400> SEQUENCE: 118 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp
Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu
Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr
Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80
Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85
90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn
Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg
Tyr Asp Glu Val Val 130 135 140 Val Gly Gly Glu Ala Ile Val Leu Thr
Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu
Lys Pro Gly Thr Glu Tyr Tyr Val Asn Ile 165 170 175 Leu Gly Val Lys
Gly Gly Ser Ile Ser Val Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Ala Glu Ala 195 200 205
Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr 210
215 220 Tyr Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys
Ala 225 230 235 240 Leu Leu Asp Glu Ile Leu Ala Ala Leu Pro 245 250
<210> SEQ ID NO 119 <211> LENGTH: 250 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding
molecule <400> SEQUENCE: 119 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Ala Asp Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Asp Glu Val Val 130 135 140 Val Gly Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160
Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Tyr Val Asn Ile 165
170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Val Pro Leu Ser Ala Ile
Phe 180 185 190 Thr Thr Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu
Ala Glu Ala 195 200 205 Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr
Gly Val Ser Asp Tyr 210 215 220 Tyr Lys Asn Leu Ile Asn Asn Ala Lys
Thr Val Glu Gly Val Lys Ala 225 230 235 240 Leu Leu Asp Glu Ile Leu
Ala Ala Leu Pro 245 250 <210> SEQ ID NO 120 <211>
LENGTH: 250 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Bispecific EGFR/c-Met binding molecule <400> SEQUENCE: 120
Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5
10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser
Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala
Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu
Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr
Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Met Arg Gly Leu
Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro
Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser
Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro
Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu 130 135
140 Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser
145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val
Val Asn Ile 165 170 175 Met Gly Val Lys Gly Gly Lys Ile Ser Pro Pro
Leu Ser Ala Ile Phe 180 185 190 Thr Thr Ala Pro Ala Pro Ala Pro Ala
Pro Ala Pro Leu Ala Glu Ala 195 200 205 Lys Val Leu Ala Asn Arg Glu
Leu Asp Lys Tyr Gly Val Ser Asp Tyr 210 215 220 Tyr Lys Asn Leu Ile
Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala 225 230 235 240 Leu Leu
Asp Glu Ile Leu Ala Ala Leu Pro 245 250 <210> SEQ ID NO 121
<211> LENGTH: 250 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding molecule <400>
SEQUENCE: 121 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Ala Asp Pro His Gly
Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu
Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Val Val Asn Ile 165 170 175 Met Gly Val Lys Gly Gly Lys
Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr Ala Pro Ala
Pro Ala Pro Ala Pro Ala Pro Leu Ala Glu Ala 195 200 205 Lys Val Leu
Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr 210 215 220 Tyr
Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala 225 230
235 240 Leu Leu Asp Glu Ile Leu Ala Ala Leu Pro 245 250 <210>
SEQ ID NO 122 <211> LENGTH: 95 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 122 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Leu Arg Leu Ser Trp Ala Asp Pro His Gly
Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90 95
<210> SEQ ID NO 123 <211> LENGTH: 95 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 123 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Leu Arg Leu Ser Trp Thr Tyr Asp Arg Asp
Gly Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90 95
<210> SEQ ID NO 124 <211> LENGTH: 95 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 124 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Leu Arg Leu Ser Trp Gly Tyr Asn Gly Asp
His Phe Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90 95
<210> SEQ ID NO 125 <211> LENGTH: 95 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 125 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Leu Arg Leu Ser Trp Asp Asp Pro Arg Gly
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90 95
<210> SEQ ID NO 126 <211> LENGTH: 95 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 126 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Leu Arg Leu Ser Trp Thr Trp
Pro Tyr Ala Asp Leu Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu
Ser Glu Lys Val Gly Glu Ala Ile Asn Leu 35 40 45 Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr
Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80
Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90
95 <210> SEQ ID NO 127 <211> LENGTH: 95 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 127 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Leu Arg Leu Ser Trp Gly Tyr
Asn Gly Asp His Phe Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu
Ser Glu Lys Val Gly Glu Ala Ile Asn Leu 35 40 45 Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr
Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80
Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90
95 <210> SEQ ID NO 128 <211> LENGTH: 96 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 128 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Leu Arg Leu Ser Trp Asp Tyr
Asp Leu Gly Val Tyr Phe Asp Ser 20 25 30 Phe Leu Ile Gln Tyr Gln
Glu Ser Glu Lys Val Gly Glu Ala Ile Asn 35 40 45 Leu Thr Val Pro
Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 50 55 60 Pro Gly
Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr 65 70 75 80
Lys Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85
90 95 <210> SEQ ID NO 129 <211> LENGTH: 95 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 129 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Leu Arg Leu Ser Trp Asp Asp
Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu
Ser Glu Lys Val Gly Glu Ala Ile Asn Leu 35 40 45 Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr
Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80
Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90
95 <210> SEQ ID NO 130 <211> LENGTH: 95 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 130 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Leu Arg Leu Ser Trp Thr Ala
Pro Asp Ala Ala Phe Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu
Ser Glu Lys Val Gly Glu Ala Ile Asn Leu 35 40 45 Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr
Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Gly Ser Tyr Val 65 70 75 80
Phe Glu His Asp Val Met Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90
95 <210> SEQ ID NO 131 <211> LENGTH: 95 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 131 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp
Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu
Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr
Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80
Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr 85 90
95 <210> SEQ ID NO 132 <211> LENGTH: 95 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 132 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Thr Ala
Pro Asp Ala Ala Phe Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu
Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr
Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Gly Ser Tyr Val 65 70 75 80
Phe Glu His Asp Val Met Leu Pro Leu Ser Ala Ile Phe Thr Thr 85 90
95 <210> SEQ ID NO 133 <211> LENGTH: 95 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 133 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Leu Arg Leu Ser Trp Thr Trp
Pro Tyr Ala Asp Leu Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu
Ser Glu Lys Val Gly Glu Ala Ile Asn Leu 35 40 45 Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr
Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80
Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90
95 <210> SEQ ID NO 134 <211> LENGTH: 95 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: EGFR binding FN3 domain
<400> SEQUENCE: 134 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Ala Asp
Pro His Gly Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu
Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr
Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80
Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr 85 90
95 <210> SEQ ID NO 135 <211> LENGTH: 95 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 135 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr 85 90 95
<210> SEQ ID NO 136 <211> LENGTH: 95 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 136 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro His Ala
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr 85 90 95
<210> SEQ ID NO 137 <211> LENGTH: 95 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain <400>
SEQUENCE: 137 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Ala Asp Pro His Gly
Phe Tyr Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr 85 90 95
<210> SEQ ID NO 138 <211> LENGTH: 204 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 138 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
Trp Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85
90 95 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly 100 105 110 Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Arg Val Thr 115 120 125 Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
Asp Ala Ala Phe Asp 130 135 140 Ser Phe Trp Ile Arg Tyr Asp Glu Val
Val Val Gly Gly Glu Ala Ile 145 150 155 160 Val Leu Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 165 170 175 Lys Pro Gly Thr
Glu Tyr Tyr Val Asn Ile Leu Gly Val Lys Gly Gly 180 185 190 Ser Ile
Ser Val Pro Leu Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID
NO 139 <211> LENGTH: 203 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 139 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85 90 95 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 100 105
110 Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu
115 120 125 Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe
Asp Ser 130 135 140 Phe Trp Ile Arg Tyr Phe Glu Phe Leu Gly Ser Gly
Glu Ala Ile Val 145 150 155 160 Leu Thr Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys 165 170 175 Pro Gly Thr Glu Tyr Val Val
Asn Ile Met Gly Val Lys Gly Gly Lys 180 185 190 Ile Ser Pro Pro Leu
Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID NO 140
<211> LENGTH: 204 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 140 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85 90 95 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 100 105
110 Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
115 120 125 Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp 130 135 140 Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile 145 150 155 160 Val Leu Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu 165 170 175 Lys Pro Gly Thr Glu Tyr Val
Val Gln Ile Ile Gly Val Lys Gly Gly 180 185 190 His Ile Ser Leu Pro
Leu Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID NO 141
<211> LENGTH: 204 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 141 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85 90 95 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 100 105
110 Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val
Thr
115 120 125 Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp 130 135 140 Ser Phe Phe Ile Arg Tyr Asp Glu Phe Leu Arg Ser
Gly Glu Ala Ile 145 150 155 160 Val Leu Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu 165 170 175 Lys Pro Gly Thr Glu Tyr Trp
Val Thr Ile Leu Gly Val Lys Gly Gly 180 185 190 Leu Val Ser Thr Pro
Leu Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID NO 142
<211> LENGTH: 204 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 142 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe
Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85 90 95 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 100 105
110 Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
115 120 125 Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp 130 135 140 Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile 145 150 155 160 Val Leu Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu 165 170 175 Lys Pro Gly Thr Glu Tyr Val
Val Asn Ile Met Gly Val Lys Gly Gly 180 185 190 Lys Ile Ser Pro Pro
Leu Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID NO 143
<211> LENGTH: 204 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 143 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe
Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85 90 95 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 100 105
110 Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
115 120 125 Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp 130 135 140 Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile 145 150 155 160 Val Leu Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu 165 170 175 Lys Pro Gly Thr Glu Tyr Val
Val Gln Ile Ile Gly Val Lys Gly Gly 180 185 190 His Ile Ser Leu Pro
Leu Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID NO 144
<211> LENGTH: 204 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 144 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe
Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 85 90 95 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 100 105
110 Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr
115 120 125 Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala
Phe Asp 130 135 140 Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu Gly Ser
Gly Glu Ala Ile 145 150 155 160 Val Leu Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu 165 170 175 Lys Pro Gly Thr Glu Tyr Val
Val Gln Ile Ile Gly Val Lys Gly Gly 180 185 190 His Ile Ser Leu Pro
Leu Ser Ala Ile Phe Thr Thr 195 200 <210> SEQ ID NO 145
<211> LENGTH: 193 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 145 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105
110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe
Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser
Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr
Glu Tyr Val Val Asn Ile Met 165 170 175 Gly Val Lys Gly Gly Lys Ile
Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr <210> SEQ
ID NO 146 <211> LENGTH: 193 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 146 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105
110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Asp Glu Val
Val Val 130 135 140 Gly Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser
Glu Arg Ser Tyr 145 150 155 160
Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Tyr Val Asn Ile Leu 165
170 175 Gly Val Lys Gly Gly Ser Ile Ser Val Pro Leu Ser Ala Ile Phe
Thr 180 185 190 Thr <210> SEQ ID NO 147 <211> LENGTH:
194 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Bispecific
EGFR/c-Met binding domain <400> SEQUENCE: 147 Leu Pro Ala Pro
Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg
Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe Leu 20 25 30
Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35
40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro
Gly 50 55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val
Tyr Lys Asp 65 70 75 80 Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile
Phe Thr Thr Ala Pro 85 90 95 Ala Pro Ala Pro Ala Pro Ala Pro Met
Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu
Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe
Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly
Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160
Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165
170 175 Met Gly Val Lys Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile
Phe 180 185 190 Thr Thr <210> SEQ ID NO 148 <211>
LENGTH: 193 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Bispecific EGFR/c-Met binding domain <400> SEQUENCE: 148 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5 10
15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe Leu
20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val
His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met Arg Gly Leu Pro Leu
Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala Pro Ala Pro Ala Pro
Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105 110 Val Ser Arg Val
Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro 115 120 125 Asp Ala
Ala Phe Asp Ser Phe Trp Ile Arg Tyr Asp Glu Val Val Val 130 135 140
Gly Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr 145
150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Tyr Val Asn
Ile Leu 165 170 175 Gly Val Lys Gly Gly Ser Ile Ser Val Pro Leu Ser
Ala Ile Phe Thr 180 185 190 Thr <210> SEQ ID NO 149
<211> LENGTH: 193 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 149 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Ile
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105
110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe
Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser
Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr
Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly Gly Lys Ile
Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr <210> SEQ
ID NO 150 <211> LENGTH: 193 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 150 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Ile
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105
110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe
Val Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser
Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr
Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly Gly Ser Ile
Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr <210> SEQ
ID NO 151 <211> LENGTH: 193 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 151 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Ile
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105
110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe
Val Ser 130 135 140 Lys Gly Asp Ala Ile Val Leu Thr Val Pro Gly Ser
Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr
Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly Gly Ser Ile
Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr <210> SEQ
ID NO 152 <211> LENGTH: 193 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 152 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
Trp Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Ser Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 153 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 153 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
His Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 154 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 154 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
His Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Val Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 155 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 155 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
His Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Val Ser 130 135 140 Lys Gly Asp Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 156 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 156 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro
His Ala Phe Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser
Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu
Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80
Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85
90 95 Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu
Val 100 105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp
Thr Ala Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr
Phe Glu Phe Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val
Pro Gly Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys
Pro Gly Thr Glu Tyr Val Val Asn Ile Leu 165 170 175 Ser Val Lys Gly
Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr
<210> SEQ ID NO 157 <211> LENGTH: 193 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding domain
<400> SEQUENCE: 157 Leu Pro Ala Pro Lys Asn Leu Val Val Ser
Glu Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro
His Gly Phe Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser
Glu Lys Val Gly Glu Ala Ile Val Leu Thr
35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys
Pro Gly 50 55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn
Val Tyr Lys Asp 65 70 75 80 Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala
Ile Phe Thr Thr Ala Pro 85 90 95 Ala Pro Ala Pro Ala Pro Ala Pro
Leu Pro Ala Pro Lys Asn Leu Val 100 105 110 Val Ser Arg Val Thr Glu
Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro 115 120 125 Asp Ala Ala Phe
Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Leu Gly 130 135 140 Ser Gly
Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr 145 150 155
160 Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile Leu
165 170 175 Gly Val Lys Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile
Phe Thr 180 185 190 Thr <210> SEQ ID NO 158 <211>
LENGTH: 193 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Bispecific EGFR/c-Met binding domain <400> SEQUENCE: 158 Leu
Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5 10
15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe Tyr Asp Ser Phe Leu
20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val
Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly
Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val
His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Ile Arg Gly Leu Pro Leu
Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala Pro Ala Pro Ala Pro
Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105 110 Val Ser Arg Val
Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro 115 120 125 Asp Ala
Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Val Gly 130 135 140
Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr 145
150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn
Ile Leu 165 170 175 Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser
Ala Ile Phe Thr 180 185 190 Thr <210> SEQ ID NO 159
<211> LENGTH: 193 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 159 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe
Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Ile
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105
110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe
Val Ser 130 135 140 Lys Gly Asp Ala Ile Val Leu Thr Val Pro Gly Ser
Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr
Glu Tyr Val Val Asn Ile Leu 165 170 175 Gly Val Lys Gly Gly Ser Ile
Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr <210> SEQ
ID NO 160 <211> LENGTH: 193 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 160 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe
Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Ile
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105
110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe
Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser
Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr
Glu Tyr Val Val Asn Ile Leu 165 170 175 Ser Val Lys Gly Gly Ser Ile
Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr <210> SEQ
ID NO 161 <211> LENGTH: 193 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 161 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Ile
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105
110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe
Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser
Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr
Glu Tyr Val Val Asn Ile Leu 165 170 175 Ser Val Lys Gly Gly Ser Ile
Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr <210> SEQ
ID NO 162 <211> LENGTH: 249 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 162 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100
105 110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
Pro 115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Asp Glu
Val Val Val 130 135 140 Gly Gly Glu Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Tyr Val Asn Ile Leu 165 170 175 Gly Val Lys Gly Gly Ser
Ile Ser Val Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr Ala Pro Ala
Pro Ala Pro Ala Pro Ala Pro Leu Ala Glu Ala Lys 195 200 205 Val Leu
Ala Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr Tyr 210 215 220
Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala Leu 225
230 235 240 Leu Asp Glu Ile Leu Ala Ala Leu Pro 245 <210> SEQ
ID NO 163 <211> LENGTH: 249 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 163 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe
Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105
110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Asp Glu Val
Val Val 130 135 140 Gly Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser
Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr
Glu Tyr Tyr Val Asn Ile Leu 165 170 175 Gly Val Lys Gly Gly Ser Ile
Ser Val Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr Ala Pro Ala Pro
Ala Pro Ala Pro Ala Pro Leu Ala Glu Ala Lys 195 200 205 Val Leu Ala
Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr Tyr 210 215 220 Lys
Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala Leu 225 230
235 240 Leu Asp Glu Ile Leu Ala Ala Leu Pro 245 <210> SEQ ID
NO 164 <211> LENGTH: 249 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 164 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe
Tyr Glu Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105
110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe
Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser
Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr
Glu Tyr Val Val Asn Ile Met 165 170 175 Gly Val Lys Gly Gly Lys Ile
Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr Ala Pro Ala Pro
Ala Pro Ala Pro Ala Pro Leu Ala Glu Ala Lys 195 200 205 Val Leu Ala
Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr Tyr 210 215 220 Lys
Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala Leu 225 230
235 240 Leu Asp Glu Ile Leu Ala Ala Leu Pro 245 <210> SEQ ID
NO 165 <211> LENGTH: 249 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 165 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Ala Arg Leu Ser Trp Ala Asp Pro His Gly Phe
Tyr Asp Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Glu Ser Glu Lys Val
Gly Glu Ala Ile Val Leu Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser
Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr Glu Tyr Thr Val
Ser Ile Tyr Gly Val His Asn Val Tyr Lys Asp 65 70 75 80 Thr Asn Met
Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro 85 90 95 Ala
Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val 100 105
110 Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro
115 120 125 Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe
Leu Gly 130 135 140 Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser
Glu Arg Ser Tyr 145 150 155 160 Asp Leu Thr Gly Leu Lys Pro Gly Thr
Glu Tyr Val Val Asn Ile Met 165 170 175 Gly Val Lys Gly Gly Lys Ile
Ser Pro Pro Leu Ser Ala Ile Phe Thr 180 185 190 Thr Ala Pro Ala Pro
Ala Pro Ala Pro Ala Pro Leu Ala Glu Ala Lys 195 200 205 Val Leu Ala
Asn Arg Glu Leu Asp Lys Tyr Gly Val Ser Asp Tyr Tyr 210 215 220 Lys
Asn Leu Ile Asn Asn Ala Lys Thr Val Glu Gly Val Lys Ala Leu 225 230
235 240 Leu Asp Glu Ile Leu Ala Ala Leu Pro 245 <210> SEQ ID
NO 166 <211> LENGTH: 588 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 166 ttgccagcgc cgaagaacct ggtagttagc gaggttactg
aggacagcgc gcgtctgagc 60 tgggacgatc cgtgggcgtt ctacgagagc
tttctgatcc agtatcaaga gagcgagaaa 120 gtcggtgaag cgattgtgct
gaccgtcccg ggctccgagc gttcctacga cctgaccggt 180 ttgaagccgg
gtaccgagta tacggtgagc atctacggtg ttcacaatgt ctataaggac 240
actaatatcc gcggtctgcc tctgagcgcc attttcacca ccgcaccggc accggctccg
300 gctcctgccc cgctgccggc tccgaagaac ttggtggtga gccgtgttac
cgaagatagc 360 gcacgcctga gctggacggc accggatgcg gcgttcgata
gcttctggat tcgctatttt 420 gagtttctgg gtagcggtga ggcaattgtt
ctgacggtgc cgggctctga acgctcctac 480 gatttgaccg gtctgaaacc
gggcaccgag tatgtggtga acattctgag cgttaagggc 540 ggtagcatca
gcccaccgct gagcgcgatc ttcacgactg gtggttgc 588 <210> SEQ ID NO
167 <211> LENGTH: 579 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding domain <400>
SEQUENCE: 167 ctgccagccc ctaagaatct ggtcgtgagc gaagtaaccg
aggacagcgc ccgcctgagc 60 tgggacgacc cgtgggcgtt ctatgagtct
ttcctgattc agtatcaaga aagcgaaaaa 120 gttggcgaag cgatcgtcct
gaccgtcccg ggtagcgagc gctcctacga tctgaccggc 180 ctgaaaccgg
gtacggagta cacggtgtcc atttacggtg ttcacaatgt gtataaagac 240
accaacatgc gtggcctgcc gctgtcggcg attttcacca ccgcgcctgc gccagcgcct
300 gcaccggctc cgctgccggc accgaagaac ctggttgtca gccgtgtgac
cgaggatagc 360 gcacgtttga gctggaccgc tccggatgca gcctttgaca
gcttctggat tcgttacttt 420 gaatttctgg gtagcggtga ggcgatcgtt
ctgacggtgc cgggctctga acgcagctat 480 gatttgacgg gcctgaagcc
gggtactgag tacgtggtta acatcatggg cgttaagggt 540 ggtaaaatca
gcccgccatt gtccgcgatc tttaccacg 579 <210> SEQ ID NO 168
<211> LENGTH: 282 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: EGFR binding FN3 domain from ECB97 <400>
SEQUENCE: 168 ttgccagcgc cgaagaacct ggtagttagc gaggttactg
aggacagcgc gcgtctgagc 60 tgggacgatc cgtgggcgtt ctacgagagc
tttctgatcc agtatcaaga gagcgagaaa 120 gtcggtgaag cgattgtgct
gaccgtcccg ggctccgagc gttcctacga cctgaccggt 180 ttgaagccgg
gtaccgagta tacggtgagc atctacggtg ttcacaatgt ctataaggac 240
actaatatcc gcggtctgcc tctgagcgcc attttcacca cc 282 <210> SEQ
ID NO 169 <211> LENGTH: 282 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: EGFR binding FN3 domain from ECB15 <400>
SEQUENCE: 169 ctgccagccc ctaagaatct ggtcgtgagc gaagtaaccg
aggacagcgc ccgcctgagc 60 tgggacgacc cgtgggcgtt ctatgagtct
ttcctgattc agtatcaaga aagcgaaaaa 120 gttggcgaag cgatcgtcct
gaccgtcccg ggtagcgagc gctcctacga tctgaccggc 180 ctgaaaccgg
gtacggagta cacggtgtcc atttacggtg ttcacaatgt gtataaagac 240
accaacatgc gtggcctgcc gctgtcggcg attttcacca cc 282 <210> SEQ
ID NO 170 <211> LENGTH: 195 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Bispecific EGFR/c-Met binding molecule
<400> SEQUENCE: 170 Met Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp
Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu
Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr
Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80
Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85
90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn
Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser
Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg
Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile Val Leu Thr
Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu
Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Gly Val Lys
Gly Gly Lys Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr
Cys 195 <210> SEQ ID NO 171 <211> LENGTH: 195
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Bispecific
EGFR/c-Met binding molecule <400> SEQUENCE: 171 Met Leu Pro
Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser
Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25
30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu
35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu
Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His
Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser
Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala
Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr
Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala
Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140 Gly Ser
Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155
160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile
165 170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala
Ile Phe 180 185 190 Thr Thr Cys 195 <210> SEQ ID NO 172
<211> LENGTH: 195 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding molecule <400>
SEQUENCE: 172 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu
Phe Val 130 135 140 Ser Lys Gly Asp Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Gly Val Lys Gly Gly Ser
Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr Cys 195
<210> SEQ ID NO 173 <211> LENGTH: 195 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding
molecule <400> SEQUENCE: 173 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu
Ser Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr Cys 195 <210> SEQ ID NO 174
<211> LENGTH: 195 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding molecule <400>
SEQUENCE: 174 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro His Ala
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu
Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Gly Val Lys Gly Gly Lys
Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr Cys 195
<210> SEQ ID NO 175 <211> LENGTH: 195 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding
molecule <400> SEQUENCE: 175 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro His Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140 Gly Ser Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu
Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr Cys 195 <210> SEQ ID NO 176 <211> LENGTH:
195 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Bispecific
EGFR/c-Met binding molecule <400> SEQUENCE: 176 Met Leu Pro
Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser
Ala Arg Leu Ser Trp Asp Asp Pro His Ala Phe Tyr Glu Ser Phe 20 25
30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu
35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu
Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His
Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser
Ala Ile Phe Thr Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala
Pro Leu Pro Ala Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr
Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala
Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu Phe Val 130 135 140 Ser Lys
Gly Asp Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155
160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile
165 170 175 Leu Gly Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala
Ile Phe 180 185 190 Thr Thr Cys 195 <210> SEQ ID NO 177
<211> LENGTH: 195 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Bispecific EGFR/c-Met binding molecule <400>
SEQUENCE: 177 Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val
Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp Asp Asp Pro His Ala
Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Ala 85 90 95 Pro
Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu 100 105
110 Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala
115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Arg Tyr Phe Glu
Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile Val Leu Thr Val Pro Gly
Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu Thr Gly Leu Lys Pro Gly
Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu Ser Val Lys Gly Gly Ser
Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185 190 Thr Thr Cys 195
<210> SEQ ID NO 178 <211> LENGTH: 195 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Bispecific EGFR/c-Met binding
molecule <400> SEQUENCE: 178 Met Leu Pro Ala Pro Lys Asn Leu
Val Val Ser Glu Val Thr Glu Asp 1 5 10 15 Ser Ala Arg Leu Ser Trp
Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 20 25 30 Leu Ile Gln Tyr
Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 35 40 45 Thr Val
Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60
Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65
70 75 80 Asp Thr Asn Ile Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr
Thr Ala 85 90 95 Pro Ala Pro Ala Pro Ala Pro Ala Pro Leu Pro Ala
Pro Lys Asn Leu 100 105 110 Val Val Ser Arg Val Thr Glu Asp Ser Ala
Arg Leu Ser Trp Thr Ala 115 120 125 Pro Asp Ala Ala Phe Asp Ser Phe
Trp Ile Arg Tyr Phe Glu Phe Leu 130 135 140 Gly Ser Gly Glu Ala Ile
Val Leu Thr Val Pro Gly Ser Glu Arg Ser 145 150 155 160 Tyr Asp Leu
Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Asn Ile 165 170 175 Leu
Ser Val Lys Gly Gly Ser Ile Ser Pro Pro Leu Ser Ala Ile Phe 180 185
190 Thr Thr Cys 195 <210> SEQ ID NO 179 <211> LENGTH:
12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Consensus FG
loop of EGFR bindiing FN3 domain
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (9)..(9) <223> OTHER INFORMATION: Xaa may be Met or
Ile <400> SEQUENCE: 179 His Asn Val Tyr Lys Asp Thr Asn Xaa
Arg Gly Leu 1 5 10 <210> SEQ ID NO 180 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: GF loop of EGFR
binding FN3 domain <400> SEQUENCE: 180 Leu Gly Ser Tyr Val
Phe Glu His Asp Val Met Leu 1 5 10 <210> SEQ ID NO 181
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Consensus BC loop of EGFR binding FN3 domain
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (1)..(1) <223> OTHER INFORMATION: Xaa may be Ala,
Thr, Gly or Asp <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
may be Ala, Asp, Tyr or Trp <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (3)..(3) <223> OTHER
INFORMATION: Xaa may be Pro, Asp or Asn <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (4)..(4)
<223> OTHER INFORMATION: Xaa may be Leu or absent <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(5)..(5) <223> OTHER INFORMATION: Xaa may be Asp, His, Arg,
Gly, Tyr or Trp <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (6)..(6) <223> OTHER INFORMATION: Xaa
may be Glu, Asp or Ala <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (7)..(7) <223> OTHER
INFORMATION: Xaa may be Ala, Phe, Gly, His or Asp <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(8)..(8) <223> OTHER INFORMATION: Xaa may be Tyr, Phe or Leu
<400> SEQUENCE: 181 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5
<210> SEQ ID NO 182 <211> LENGTH: 95 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain consensus
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (22)..(22) <223> OTHER INFORMATION: Xaa
may be Ala, Thr, Gly or Asp <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (23)..(23) <223>
OTHER INFORMATION: Xaa may be Ala, Asp, Tyr or Trp <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(24)..(24) <223> OTHER INFORMATION: Xaa may be Pro, Asp or
Asn <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (25)..(25) <223> OTHER INFORMATION: Xaa may be Leu
or absent <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION: Xaa
may be Asp, His, Arg, Gly, Tyr or Trp <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (27)..(27)
<223> OTHER INFORMATION: Xaa may be Gly, Asp or Ala
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (28)..(28) <223> OTHER INFORMATION: Xaa may be Ala,
Phe, Gly, His or Asp <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (29)..(29) <223> OTHER
INFORMATION: Xaa may be Tyr, Phe or Leu <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (84)..(84)
<223> OTHER INFORMATION: Xaa may be Met or Ile <400>
SEQUENCE: 182 Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr
Glu Asp Ser 1 5 10 15 Leu Arg Leu Ser Trp Xaa Xaa Xaa Xaa Xaa Xaa
Xaa Xaa Asp Ser Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys
Val Gly Glu Ala Ile Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg
Ser Tyr Asp Leu Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr
Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 65 70 75 80 Asp Thr Asn
Xaa Arg Gly Leu Pro Leu Ser Ala Glu Phe Thr Thr 85 90 95
<210> SEQ ID NO 183 <211> LENGTH: 95 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR binding FN3 domain consensus
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (22)..(22) <223> OTHER INFORMATION: Xaa
may be Ala, Thr, Gly or Asp <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (23)..(23) <223>
OTHER INFORMATION: Xaa may be Ala, Asp, Tyr or Trp <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(24)..(24) <223> OTHER INFORMATION: Xaa may be Pro, Asp or
Asn <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (25)..(25) <223> OTHER INFORMATION: Xaa may be Leu
or absent <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (26)..(26) <223> OTHER INFORMATION: Xaa
may be Asp, His, Arg, Gly, Tyr or Trp <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (27)..(27)
<223> OTHER INFORMATION: Xaa may be Gly, Asp or Ala
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (28)..(28) <223> OTHER INFORMATION: Xaa may be Ala,
Phe, Gly, His or Asp <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (29)..(29) <223> OTHER
INFORMATION: Xaa may be Tyr, Phe or Leu <400> SEQUENCE: 183
Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 1 5
10 15 Leu Arg Leu Ser Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Ser
Phe 20 25 30 Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala
Ile Asn Leu 35 40 45 Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu
Thr Gly Leu Lys Pro 50 55 60 Gly Thr Glu Tyr Thr Val Ser Ile Tyr
Gly Val Leu Gly Ser Tyr Val 65 70 75 80 Phe Glu His Asp Val Met Leu
Pro Leu Ser Ala Glu Phe Thr Thr 85 90 95 <210> SEQ ID NO 184
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: c-Met binding FN3 domain C strand and CD loop
consensus sequence <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (4)..(4) <223> OTHER
INFORMATION: Xaa is Trp, Phe or Val <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (8)..(8)
<223> OTHER INFORMATION: Xaa is Asp, Phe or Leu <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(10)..(10) <223> OTHER INFORMATION: Xaa is Val, Phe or Leu
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (11)..(11) <223> OTHER INFORMATION: Xaa is Val, Leu
or Thr <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (12)..(12) <223> OTHER INFORMATION: Xaa
is Val, Arg, Gly, Leu, Thr or Ser <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (13)..(13) <223>
OTHER INFORMATION: Xaa is Gly, Ser, Ala, Thr or Lys <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(15)..(15) <223> OTHER INFORMATION: Xaa is Glu or Asp
<400> SEQUENCE: 184 Asp Ser Phe Xaa Ile Arg Tyr Xaa Glu Xaa
Xaa Xaa Xaa Gly Xaa 1 5 10 15 <210> SEQ ID NO 185 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: c-Met
binding FN3 domain F strand and FG loop consensus sequence
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (4)..(4) <223> OTHER INFORMATION: Xaa is Tyr, Trp,
Ile, Val, Gly or Ala <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (6)..(6)
<223> OTHER INFORMATION: Xaa is Asn, Thr, Qln or Gly
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (8)..(8) <223> OTHER INFORMATION: Xaa is Leu, Met,
Asn or Ile <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (9)..(9) <223> OTHER INFORMATION: Xaa
is Gly or Ser <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (14)..(14) <223> OTHER INFORMATION: Xaa
is Ser, Leu, Gly, Tyr, Thr, Arg, His or Lys <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (15)..(15)
<223> OTHER INFORMATION: Xaa is Ile, Val or Leu <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is Val, Thr, His,
Ile, Pro, Tyr or Leu <400> SEQUENCE: 185 Thr Glu Tyr Xaa Val
Xaa Ile Xaa Xaa Val Lys Gly Gly Xaa Xaa Ser 1 5 10 15 Xaa
<210> SEQ ID NO 186 <211> LENGTH: 89 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met binding FN3 domain consensus
sequence <220> FEATURE: <221> NAME/KEY: VARIANT
<222> LOCATION: (32)..(32) <223> OTHER INFORMATION: Xaa
is Trp, Phe or Val <220> FEATURE: <221> NAME/KEY:
VARIANT <222> LOCATION: (36)..(36) <223> OTHER
INFORMATION: Xaa is Asp, Phe or Leu <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (38)..(38)
<223> OTHER INFORMATION: Xaa is Val, Phe or Leu <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(39)..(39) <223> OTHER INFORMATION: Xaa is Val, Leu or Thr
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Xaa is Val,
Arg, Gly, Leu, Thr or Ser <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (41)..(41) <223>
OTHER INFORMATION: Xaa is Gly, Ser, Ala, Thr or Lys <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(43)..(43) <223> OTHER INFORMATION: Xaa is Glu or Asp
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (68)..(68) <223> OTHER INFORMATION: Xaa is Tyr,
Trp, Ile, Val, Gly or Ala <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (70)..(70) <223>
OTHER INFORMATION: Xaa is Asn, Thr, Qln or Gly <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (72)..(72)
<223> OTHER INFORMATION: Xaa is Leu, Met, Asn or Ile
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (73)..(73) <223> OTHER INFORMATION: Xaa is Gly or
Ser <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (78)..(78) <223> OTHER INFORMATION: Xaa is Ser,
Leu, Gly, Tyr, Thr, Arg, His or Lys <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (79)..(79)
<223> OTHER INFORMATION: Xaa is Ile, Val or Leu <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(81)..(81) <223> OTHER INFORMATION: Xaa is Val, Thr, His,
Ile, Pro, Tyr or Leu <400> SEQUENCE: 186 Leu Pro Ala Pro Lys
Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 1 5 10 15 Ala Arg Leu
Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Xaa 20 25 30 Ile
Arg Tyr Xaa Glu Xaa Xaa Xaa Xaa Gly Xaa Ala Ile Val Leu Thr 35 40
45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly
50 55 60 Thr Glu Tyr Xaa Val Xaa Ile Xaa Xaa Val Lys Gly Gly Xaa
Xaa Ser 65 70 75 80 Xaa Pro Leu Ser Ala Glu Phe Thr Thr 85
<210> SEQ ID NO 187 <211> LENGTH: 94 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: EGFR consensus FN3 domain of
bispecific EGFR/c-Met molecule <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (11)..(11) <223>
OTHER INFORMATION: Xaa is Glu, Asn or Arg <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (14)..(14)
<223> OTHER INFORMATION: Xaa is Glu or Pro <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is Leu or Ala
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (25)..(25) <223> OTHER INFORMATION: Xaa is His or
Trp <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (29)..(29) <223> OTHER INFORMATION: Xaa is Glu or
Asp <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (37)..(37) <223> OTHER INFORMATION: Xaa is Glu or
Pro <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (46)..(46) <223> OTHER INFORMATION: Xaa is Asn or
Val <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (73)..(73) <223> OTHER INFORMATION: Xaa is Gly or
Tyr <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (83)..(83) <223> OTHER INFORMATION: Xaa is Met or
Ile <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (91)..(91) <223> OTHER INFORMATION: Xaa is Glu or
Ile <400> SEQUENCE: 187 Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Xaa Val Thr Xaa Asp Ser 1 5 10 15 Xaa Arg Leu Ser Trp Asp Asp
Pro Xaa Ala Phe Tyr Xaa Ser Phe Leu 20 25 30 Ile Gln Tyr Gln Xaa
Ser Glu Lys Val Gly Glu Ala Ile Xaa Leu Thr 35 40 45 Val Pro Gly
Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 50 55 60 Thr
Glu Tyr Thr Val Ser Ile Tyr Xaa Val His Asn Val Tyr Lys Asp 65 70
75 80 Thr Asn Xaa Arg Gly Leu Pro Leu Ser Ala Xaa Phe Thr Thr 85 90
<210> SEQ ID NO 188 <211> LENGTH: 89 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: c-Met consensus FN3 domain of
bispecific EGFR/c-Met molecule <220> FEATURE: <221>
NAME/KEY: VARIANT <222> LOCATION: (11)..(11) <223>
OTHER INFORMATION: Xaa is Glu, Asn or Arg <220> FEATURE:
<221> NAME/KEY: VARIANT <222> LOCATION: (14)..(14)
<223> OTHER INFORMATION: Xaa is Glu or Pro <220>
FEATURE: <221> NAME/KEY: VARIANT <222> LOCATION:
(17)..(17) <223> OTHER INFORMATION: Xaa is Leu or Ala
<220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (37)..(37) <223> OTHER INFORMATION: Xaa is Glu or
Pro <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (39)..(39) <223> OTHER INFORMATION: Xaa is Val or
Leu <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (40)..(40) <223> OTHER INFORMATION: Xaa is Gly or
Ser <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (41)..(41) <223> OTHER INFORMATION: Xaa is Ser or
Lys <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (43)..(43) <223> OTHER INFORMATION: Xaa is Glu or
Asp <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (46)..(46) <223> OTHER INFORMATION: Xaa is Asn or
Val <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (72)..(72) <223> OTHER INFORMATION: Xaa is Leu or
Met <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (73)..(73) <223> OTHER INFORMATION: Xaa is Gly or
Ser <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (78)..(78) <223> OTHER INFORMATION: Xaa is Ser or
Lys <220> FEATURE: <221> NAME/KEY: VARIANT <222>
LOCATION: (86)..(86) <223> OTHER INFORMATION: Xaa is Glu or
Ile <400> SEQUENCE: 188 Leu Pro Ala Pro Lys Asn Leu Val Val
Ser Xaa Val Thr Xaa Asp Ser 1 5 10 15
Xaa Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 20
25 30 Ile Arg Tyr Phe Xaa Phe Xaa Xaa Xaa Gly Xaa Ala Ile Xaa Leu
Thr 35 40 45 Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu
Lys Pro Gly 50 55 60 Thr Glu Tyr Val Val Asn Ile Xaa Xaa Val Lys
Gly Gly Xaa Ile Ser 65 70 75 80 Pro Pro Leu Ser Ala Xaa Phe Thr Thr
85 <210> SEQ ID NO 189 <211> LENGTH: 125 <212>
TYPE: PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE:
189 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Asp Asp Gly Ser Tyr Lys
Tyr Tyr Gly Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly
Ile Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe 100 105 110 Asp Tyr
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210>
SEQ ID NO 190 <211> LENGTH: 107 <212> TYPE: PRT
<213> ORGANISM: Homo Sapiens <400> SEQUENCE: 190 Ala
Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10
15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala
20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser
Arg Phe Ser Gly 50 55 60 Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr
Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys
Gln Gln Phe Asn Ser Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr
Lys Val Glu Ile Lys 100 105 <210> SEQ ID NO 191 <211>
LENGTH: 121 <212> TYPE: PRT <213> ORGANISM: Homo
Sapiens <400> SEQUENCE: 191 Glu Val Gln Leu Val Glu Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn
Ile Lys Lys Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65
70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Asp Leu Gly Trp Gly Trp Gly Trp Tyr Phe
Asp Leu Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val Ser Ser 115
120 <210> SEQ ID NO 192 <211> LENGTH: 107 <212>
TYPE: PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE:
192 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser
Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile
Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr
Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr
Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Thr Phe Gly Gln
Gly Thr Lys Val Glu Ile Lys 100 105 <210> SEQ ID NO 193
<211> LENGTH: 119 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 193 Gln Val Gln Leu Val Gln Ser
Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser
Cys Glu Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Gly Ile Ser
Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Met 35 40 45 Gly
Trp Ile Ser Ala Tyr Asn Gly Tyr Thr Asn Tyr Ala Gln Lys Leu 50 55
60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Asp Leu Arg Gly Thr Asn Tyr Phe Asp Tyr
Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115
<210> SEQ ID NO 194 <211> LENGTH: 107 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 194
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5
10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn
Trp 20 25 30 Leu Ala Trp Phe Gln His Lys Pro Gly Lys Ala Pro Lys
Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Leu Ser Gly Val Pro
Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr
Cys Gln Gln Ala Asn Ser Phe Pro Ile 85 90 95 Thr Phe Gly Gln Gly
Thr Arg Leu Glu Ile Lys 100 105 <210> SEQ ID NO 195
<211> LENGTH: 125 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 195 Glu Val Gln Leu Val Glu Ser
Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Lys Leu Ser
Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Tyr Met Tyr
Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 35 40 45 Ala
Thr Ile Ser Asp Asp Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 50 55
60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr
65 70 75 80 Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr
Tyr Cys 85 90 95 Ala Arg Glu Gly Leu Tyr Tyr Tyr Gly Ser Gly Ser
Tyr Tyr Asn Gln 100 105 110 Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser 115 120 125 <210> SEQ ID NO 196 <211>
LENGTH: 106 <212> TYPE: PRT <213> ORGANISM: Homo
Sapiens <400> SEQUENCE: 196 Gln Leu Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly Asp Arg 1 5 10 15 Val Thr Ile Thr Cys Arg
Ala Ser Gln Gly Leu Ser Ser Ala Leu Ala 20 25 30 Trp Tyr Arg Gln
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp 35 40 45 Ala Ser
Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 50 55 60
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
65 70 75 80 Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Tyr Pro Gln
Ile Thr 85 90 95 Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105
<210> SEQ ID NO 197 <211> LENGTH: 457 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 197
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5
10 15 Ser Val Lys Val Ser Cys Gln Ala Ser Gly Tyr Arg Phe Ser Asn
Phe 20 25 30 Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Phe
Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Tyr Asn Gly Asn Lys Glu
Phe Ser Ala Lys Phe 50 55 60 Gln Asp Arg Val Thr Phe Thr Ala Asp
Thr Ser Ala Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg
Ser Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Gly Pro
Tyr Ser Trp Asp Asp Ser Pro Gln Asp Asn Tyr 100 105 110 Tyr Met Asp
Val Trp Gly Lys Gly Thr Thr Val Ile Val Ser Ser Ala 115 120 125 Ser
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 130 135
140 Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
145 150 155 160 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
Thr Ser Gly 165 170 175 Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
Gly Leu Tyr Ser Leu 180 185 190 Ser Ser Val Val Thr Val Pro Ser Ser
Ser Leu Gly Thr Gln Thr Tyr 195 200 205 Ile Cys Asn Val Asn His Lys
Pro Ser Asn Thr Lys Val Asp Lys Arg 210 215 220 Val Glu Pro Lys Ser
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 225 230 235 240 Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 245 250 255
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 260
265 270 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
Tyr 275 280 285 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
Arg Glu Glu 290 295 300 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
Leu Thr Val Leu His 305 310 315 320 Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val Ser Asn Lys 325 330 335 Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 340 345 350 Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 355 360 365 Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 370 375 380
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 385
390 395 400 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
Leu Leu 405 410 415 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln Gly Asn Val 420 425 430 Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr Thr Gln 435 440 445 Lys Ser Leu Ser Leu Ser Pro Gly
Lys 450 455 <210> SEQ ID NO 198 <211> LENGTH: 457
<212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 198 Gln Val Gln Leu Val Gln Ser Gly Ala Glu
Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Gln Ala
Ser Gly Tyr Arg Phe Ser Asn Phe 20 25 30 Val Ile His Trp Val Arg
Gln Ala Pro Gly Gln Arg Phe Glu Trp Met 35 40 45 Gly Trp Ile Asn
Pro Tyr Asn Gly Asn Lys Glu Phe Ser Ala Lys Phe 50 55 60 Gln Asp
Arg Val Thr Phe Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 65 70 75 80
Met Glu Leu Arg Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Val Gly Pro Tyr Ser Trp Asp Asp Ser Pro Gln Asp Asn
Tyr 100 105 110 Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Ile Val
Ser Ser Ala 115 120 125 Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala
Pro Ser Ser Lys Ser 130 135 140 Thr Ser Gly Gly Thr Ala Ala Leu Gly
Cys Leu Val Lys Asp Tyr Phe 145 150 155 160 Pro Glu Pro Val Thr Val
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 165 170 175 Val His Thr Phe
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 180 185 190 Ser Ser
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 195 200 205
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 210
215 220 Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
Pro 225 230 235 240 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys 245 250 255 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys Val 260 265 270 Val Val Asp Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr 275 280 285 Val Asp Gly Val Glu Val
His Asn Ala Lys Thr Lys Pro Arg Glu Glu 290 295 300 Gln Tyr Asn Ser
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 305 310 315 320 Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 325 330
335 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
340 345 350 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
Glu Met 355 360 365 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro 370 375 380 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn 385 390 395 400 Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu 405 410 415 Tyr Ser Arg Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 420 425 430 Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 435 440 445 Lys
Ser Leu Ser Leu Ser Pro Gly Lys 450 455 <210> SEQ ID NO 199
<211> LENGTH: 455 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 199 Gln Val Gln Leu Val Glu Ser
Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser
Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Gly Met His
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala
Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val 50 55
60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Asp Gly Ile Thr Met Val Arg Gly Val Met
Lys Asp Tyr Phe 100 105 110 Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser Ala Ser Thr 115 120 125 Lys Gly Pro Ser Val Phe Pro Leu
Ala Pro Ser Ser Lys Ser Thr Ser 130 135 140 Gly Gly Thr Ala Ala Leu
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 145 150 155 160 Pro Val Thr
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 165 170 175 Thr
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 180 185
190 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
195 200 205 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg
Val Glu 210 215 220 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
Cys Pro Ala Pro 225 230 235 240
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 245
250 255 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
Val 260 265 270 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
Tyr Val Asp 275 280 285 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
Arg Glu Glu Gln Tyr 290 295 300 Asn Ser Thr Tyr Arg Val Val Ser Val
Leu Thr Val Leu His Gln Asp 305 310 315 320 Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 325 330 335 Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 340 345 350 Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 355 360 365
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 370
375 380 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
Lys 385 390 395 400 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
Leu Leu Tyr Ser 405 410 415 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln Gly Asn Val Phe Ser 420 425 430 Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr Thr Gln Lys Ser 435 440 445 Leu Ser Leu Ser Pro Gly
Lys 450 455 <210> SEQ ID NO 200 <211> LENGTH: 214
<212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 200 Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser
Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Gln Asp Ile Ser Ser Ala 20 25 30 Leu Val Trp Tyr Gln Gln
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser
Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Glu
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 85
90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala
Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu
Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala
Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln
Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr
Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys
Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205
Phe Asn Arg Gly Glu Cys 210 <210> SEQ ID NO 201 <211>
LENGTH: 449 <212> TYPE: PRT <213> ORGANISM: Homo
Sapiens <400> SEQUENCE: 201 Gln Val Gln Leu Val Gln Ser Gly
Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys
Glu Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Gly Ile Ser Trp
Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Met 35 40 45 Gly Trp
Ile Ser Ala Tyr Asn Gly Tyr Thr Asn Tyr Ala Gln Lys Leu 50 55 60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65
70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Asp Leu Arg Gly Thr Asn Tyr Phe Asp Tyr
Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser Ala Ser Thr
Lys Gly Pro Ser Val Phe 115 120 125 Pro Leu Ala Pro Ser Ser Lys Ser
Thr Ser Gly Gly Thr Ala Ala Leu 130 135 140 Gly Cys Leu Val Lys Asp
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 145 150 155 160 Asn Ser Gly
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 165 170 175 Gln
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 180 185
190 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
195 200 205 Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys
Asp Lys 210 215 220 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
Leu Gly Gly Pro 225 230 235 240 Ser Val Phe Leu Phe Pro Pro Lys Pro
Lys Asp Thr Leu Met Ile Ser 245 250 255 Arg Thr Pro Glu Val Thr Cys
Val Val Val Asp Val Ser His Glu Asp 260 265 270 Pro Glu Val Lys Phe
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 275 280 285 Ala Lys Thr
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 290 295 300 Val
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 305 310
315 320 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
Lys 325 330 335 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
Val Tyr Thr 340 345 350 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
Gln Val Ser Leu Thr 355 360 365 Cys Leu Val Lys Gly Phe Tyr Pro Ser
Asp Ile Ala Val Glu Trp Glu 370 375 380 Ser Asn Gly Gln Pro Glu Asn
Asn Tyr Lys Thr Thr Pro Pro Val Leu 385 390 395 400 Asp Ser Asp Gly
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 405 410 415 Ser Arg
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 420 425 430
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435
440 445 Lys <210> SEQ ID NO 202 <211> LENGTH: 214
<212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 202 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg
Ala Ser Gln Gly Ile Ser Asn Trp 20 25 30 Leu Ala Trp Phe Gln His
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser
Ser Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Ile 85
90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala
Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu
Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala
Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln
Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr
Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys
Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205
Phe Asn Arg Gly Glu Cys 210 <210> SEQ ID NO 203 <211>
LENGTH: 330 <212> TYPE: PRT <213> ORGANISM: Homo
Sapiens <400> SEQUENCE: 203 Ala Ser Thr Lys Gly Pro Ser Val
Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50
55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
Val Asp Lys 85 90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His
Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180
185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305
310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330
<210> SEQ ID NO 204 <211> LENGTH: 330 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 204
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5
10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro Lys
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135
140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260
265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
Leu 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 325 330 <210> SEQ ID NO 205 <211> LENGTH: 1368
<212> TYPE: DNA <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 205 caggtgcagc tggtcgagag cggcggaggg
gtggtgcagc ccggcagaag cctgaggctg 60 tcctgcgccg ccagcggctt
caccttcagc acctacggca tgcactgggt gcggcaggcc 120 ccaggcaagg
gcctggagtg ggtggccgtg atctgggacg acggcagcta caagtactac 180
ggcgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac
240 ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc
cagggacggc 300 atcaccatgg tgcggggcgt gatgaaggac tacttcgact
actggggcca gggcaccctg 360 gtgaccgtga gcagcgccag caccaagggc
ccaagcgtgt tccccctggc ccccagcagc 420 aagagcacca gcggcggcac
agccgccctg ggctgcctgg tgaaggacta cttccccgag 480 ccagtgaccg
tgtcctggaa ctctggcgcc ctgacctccg gcgtgcacac cttccccgcc 540
gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc cagcagcagc
600 ctgggcaccc agacctacat ctgcaacgtg aaccacaagc ccagcaacac
caaggtggac 660 aagagagtgg agcccaagag ctgcgacaag acccacacct
gccccccctg cccagcccca 720 gagctgctgg gcggacccag cgtgttcctg
ttccccccca agcccaagga caccctgatg 780 atcagcagga cccccgaggt
gacctgcgtg gtggtggacg tgagccacga ggacccagag 840 gtgaagttca
actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcccaga 900
gaggagcagt acaacagcac ctacagggtg gtgtccgtgc tgaccgtgct gcaccaggac
960 tggctgaacg gcaaggaata caagtgcaag gtctccaaca aggccctgcc
agcccccatc 1020 gaaaagacca tcagcaaggc caagggccag ccacgggagc
cccaggtgta caccctgccc 1080 cccagccggg aggagatgac caagaaccag
gtgtccctga cctgtctggt gaagggcttc 1140 taccccagcg acatcgccgt
ggagtgggag agcaacggcc agcccgagaa caactacaag 1200 accacccccc
cagtgctgga cagcgacggc agcttcctcc tgtacagcaa gctgaccgtg 1260
gacaagtcca ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg
1320 cacaaccact acacccagaa gtccctgagc ctgagccccg gcaaatga 1368
<210> SEQ ID NO 206 <211> LENGTH: 642 <212> TYPE:
DNA <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 206
atccagctga cccagagccc cagcagcctg agcgccagcg tgggcgaccg ggtgaccatc
60 acctgccggg ccagccagga catcagcagc gccctggtct ggtatcagca
gaagcccggc 120 aaggccccca agctgctgat ctacgacgcc agctccctgg
aaagcggcgt gcccagccgg 180 ttcagcggca gcgagagcgg caccgacttc
accctgacca tcagcagcct gcagcccgag 240 gacttcgcca cctactactg
ccagcagttc aacagctacc ccctgacctt tggcggcgga 300 acaaaggtgg
agatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc 360
gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc
420 cgggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa
cagccaggag 480 agcgtcaccg agcaggacag caaggactcc acctacagcc
tgagcagcac cctgaccctg 540 tccaaggccg actacgagaa gcacaaggtg
tacgcctgcg aggtgaccca ccagggcctg 600 tccagccccg tgaccaagag
cttcaacagg ggcgagtgct ga 642 <210> SEQ ID NO 207 <211>
LENGTH: 1350 <212> TYPE: DNA <213> ORGANISM: Homo
Sapiens <400> SEQUENCE: 207 caggttcagc tggtgcagtc tggagctgag
gtgaagaagc ctggggcctc agtgaaggtc 60 tcctgcgaga cttctggtta
cacctttacc agctatggta tcagctgggt gcgacaggcc 120 cctggacacg
ggcttgagtg gatgggatgg atcagcgctt acaatggtta cacaaactat 180
gcacagaagc tccagggcag ggtcaccatg accacagaca catccacgag cacagcctac
240 atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc
gagagatctg 300 agaggaacta actactttga ctactggggc cagggaaccc
tggtcaccgt ctcctcagcc 360 tccaccaagg gcccaagcgt gttccctctg
gcccccagca gcaagagcac atctggcgga 420 acagccgccc tgggctgcct
ggtgaaagac tacttccccg agcccgtgac cgtgtcctgg 480 aactctggcg
ccctgaccag cggcgtgcac acctttccag ccgtgctgca gagcagcggc 540
ctgtacagcc tgtccagcgt ggtgaccgtg cccagcagct ccctgggcac ccagacctac
600 atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagcgggt
ggaacccaag 660 agctgcgaca agacccacac ctgtcccccc tgccctgccc
ctgaactgct gggcggaccc 720 tccgtgttcc tgttcccccc aaagcccaag
gacaccctga tgatcagccg gacccccgaa 780 gtgacctgcg tggtggtgga
cgtgtcccac gaggaccctg aagtgaagtt caattggtac 840 gtggacggcg
tggaagtgca caacgccaag accaagccca gagaggaaca gtacaacagc 900
acctaccggg tggtgtccgt gctgacagtg ctgcaccagg actggctgaa cggcaaagag
960 tacaagtgca aggtctccaa caaggccctg cctgctccca tcgagaaaac
catcagcaag 1020
gccaagggcc agccccgcga gcctcaggtg tacacactgc ctcccagccg ggaagagatg
1080 accaagaacc aggtgtccct gacctgtctg gtgaaaggct tctaccccag
cgatatcgcc 1140 gtggaatggg agagcaacgg acagcccgag aacaactaca
agaccacccc ccctgtgctg 1200 gacagcgacg gctccttctt cctgtactct
cggctgaccg tggacaagag ccggtggcag 1260 cagggaaacg tgttcagctg
cagcgtgatg cacgaggccc tgcacaacca ctacacccag 1320 aagtccctga
gcctgagccc cgggaagtga 1350 <210> SEQ ID NO 208 <211>
LENGTH: 645 <212> TYPE: DNA <213> ORGANISM: Homo
Sapiens <400> SEQUENCE: 208 gacatccaga tgacccagtc cccctcctcc
gtgtccgcct ctgtgggcga cagagtgacc 60 atcacctgtc gggcctccca
gggcatctcc aactggctgg cctggttcca gcacaagccc 120 ggcaaggccc
ccaagctgct gatctacgcc gcctcctccc tgctgtccgg cgtgccctcc 180
agattctccg gctctggctc cggcaccgac ttcaccctga ccatctccag cctgcagccc
240 gaggacttcg ccacctacta ctgccagcag gccaactcct tccccatcac
cttcggccag 300 ggcacccggc tggaaatcaa gcgtacggtg gccgctccca
gcgtgttcat cttccccccc 360 agcgacgagc agctgaagag cggcaccgcc
agcgtggtgt gcctgctgaa caacttctac 420 ccccgggagg ccaaggtgca
gtggaaggtg gacaacgccc tgcagagcgg caacagccag 480 gagagcgtca
ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540
ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc
600 ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gctga 645
<210> SEQ ID NO 209 <211> LENGTH: 215 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 209
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5
10 15 Glu Arg Ala Thr Phe Ser Cys Arg Ser Ser His Ser Ile Arg Ser
Arg 20 25 30 Arg Val Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro
Arg Leu Val 35 40 45 Ile His Gly Val Ser Asn Arg Ala Ser Gly Ile
Ser Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Thr Ile Thr Arg Val Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr
Tyr Cys Gln Val Tyr Gly Ala Ser Ser 85 90 95 Tyr Thr Phe Gly Gln
Gly Thr Lys Leu Glu Arg Lys Arg Thr Val Ala 100 105 110 Ala Pro Ser
Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 115 120 125 Gly
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 130 135
140 Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145 150 155 160 Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
Tyr Ser Leu 165 170 175 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
Glu Lys His Lys Val 180 185 190 Tyr Ala Cys Glu Val Thr His Gln Gly
Leu Ser Ser Pro Val Thr Lys 195 200 205 Ser Phe Asn Arg Gly Glu Cys
210 215 <210> SEQ ID NO 210 <211> LENGTH: 5 <212>
TYPE: PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE:
210 Thr Tyr Gly Met His 1 5 <210> SEQ ID NO 211 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 211 Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr
Tyr Gly Asp Ser Val Lys 1 5 10 15 Gly <210> SEQ ID NO 212
<211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 212 Asp Gly Ile Thr Met Val Arg
Gly Val Met Lys Asp Tyr Phe Asp Tyr 1 5 10 15 <210> SEQ ID NO
213 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 213 Arg Ala Ser Gln
Asp Ile Ser Ser Ala Leu Val 1 5 10 <210> SEQ ID NO 214
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 214 Asp Ala Ser Ser Leu Glu Ser
1 5 <210> SEQ ID NO 215 <211> LENGTH: 9 <212>
TYPE: PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE:
215 Gln Gln Phe Asn Ser Tyr Pro Leu Thr 1 5 <210> SEQ ID NO
216 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 216 Ser Tyr Gly Ile
Ser 1 5 <210> SEQ ID NO 217 <211> LENGTH: 17
<212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 217 Trp Ile Ser Ala Tyr Asn Gly Tyr Thr Asn
Tyr Ala Gln Lys Leu Gln 1 5 10 15 Gly <210> SEQ ID NO 218
<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 218 Asp Leu Arg Gly Thr Asn Tyr
Phe Asp Tyr 1 5 10 <210> SEQ ID NO 219 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 219 Arg Ala Ser Gln Gly Ile Ser Asn Trp Leu
Ala 1 5 10 <210> SEQ ID NO 220 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 220 Ala Ala Ser Ser Leu Leu Ser 1 5
<210> SEQ ID NO 221 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 221
Gln Gln Ala Asn Ser Phe Pro Ile Thr 1 5 <210> SEQ ID NO 222
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 222 Ser Tyr Trp Met Asn 1 5
<210> SEQ ID NO 223 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 223
Asn Ile Lys Lys Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 1 5
10 15 Gly
<210> SEQ ID NO 224 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 224
Asp Leu Gly Trp Gly Trp Gly Trp Tyr Phe Asp Leu 1 5 10 <210>
SEQ ID NO 225 <211> LENGTH: 11 <212> TYPE: PRT
<213> ORGANISM: Homo Sapiens <400> SEQUENCE: 225 Arg
Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> SEQ ID
NO 226 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 226 Asp Ala Ser Asn
Arg Ala Thr 1 5 <210> SEQ ID NO 227 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 227 Gln Gln Arg Ser Asn Trp Pro Pro Thr 1 5
<210> SEQ ID NO 228 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE: 228
Asp Tyr Tyr Met Tyr 1 5 <210> SEQ ID NO 229 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Homo Sapiens
<400> SEQUENCE: 229 Thr Ile Ser Asp Asp Gly Ser Tyr Thr Tyr
Tyr Pro Asp Ser Val Lys 1 5 10 15 Gly <210> SEQ ID NO 230
<211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 230 Glu Gly Leu Tyr Tyr Tyr Gly
Ser Gly Ser Tyr Tyr Asn Gln Asp Tyr 1 5 10 15 <210> SEQ ID NO
231 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 231 Arg Ala Ser Gln
Gly Leu Ser Ser Ala Leu Ala 1 5 10 <210> SEQ ID NO 232
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 232 Asp Ala Ser Ser Leu Glu Ser
1 5 <210> SEQ ID NO 233 <211> LENGTH: 10 <212>
TYPE: PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE:
233 Gln Gln Phe Thr Ser Tyr Pro Gln Ile Thr 1 5 10 <210> SEQ
ID NO 234 <211> LENGTH: 451 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 234 Glu Val Gln Leu
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35
40 45 Ala Asn Ile Lys Lys Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser
Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Leu Gly Trp Gly Trp Gly
Trp Tyr Phe Asp Leu Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val
Ser Ser Ala Ser Thr Lys Gly Pro Ser 115 120 125 Val Phe Pro Leu Ala
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 130 135 140 Ala Leu Gly
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 145 150 155 160
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 165
170 175 Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
Val 180 185 190 Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
Val Asn His 195 200 205 Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val
Glu Pro Lys Ser Cys 210 215 220 Asp Lys Thr His Thr Cys Pro Pro Cys
Pro Ala Pro Glu Leu Leu Gly 225 230 235 240 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 245 250 255 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 260 265 270 Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 275 280 285
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 290
295 300 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
Gly 305 310 315 320 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 325 330 335 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 340 345 350 Tyr Thr Leu Pro Pro Ser Arg Glu
Glu Met Thr Lys Asn Gln Val Ser 355 360 365 Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 370 375 380 Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 385 390 395 400 Val
Leu Asp Ser Asp Gly Ser Phe Leu Leu Tyr Ser Lys Leu Thr Val 405 410
415 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
420 425 430 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser 435 440 445 Pro Gly Lys 450 <210> SEQ ID NO 235
<211> LENGTH: 214 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 235 Glu Ile Val Leu Thr Gln Ser
Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu
Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr
Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55
60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp
Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu
Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val
Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val
Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185
190
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195
200 205 Phe Asn Arg Gly Glu Cys 210 <210> SEQ ID NO 236
<211> LENGTH: 455 <212> TYPE: PRT <213> ORGANISM:
Homo Sapiens <400> SEQUENCE: 236 Glu Val Gln Leu Val Glu Ser
Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Lys Leu Ser
Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Tyr Met Tyr
Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 35 40 45 Ala
Thr Ile Ser Asp Asp Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 50 55
60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr
65 70 75 80 Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr
Tyr Cys 85 90 95 Ala Arg Glu Gly Leu Tyr Tyr Tyr Gly Ser Gly Ser
Tyr Tyr Asn Gln 100 105 110 Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ser Ala Ser Thr 115 120 125 Lys Gly Pro Ser Val Phe Pro Leu
Ala Pro Ser Ser Lys Ser Thr Ser 130 135 140 Gly Gly Thr Ala Ala Leu
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 145 150 155 160 Pro Val Thr
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 165 170 175 Thr
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 180 185
190 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
195 200 205 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg
Val Glu 210 215 220 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
Cys Pro Ala Pro 225 230 235 240 Glu Leu Leu Gly Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro Lys 245 250 255 Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val Val 260 265 270 Asp Val Ser His Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 275 280 285 Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 290 295 300 Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 305 310
315 320 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
Leu 325 330 335 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro Arg 340 345 350 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Glu Glu Met Thr Lys 355 360 365 Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp 370 375 380 Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys 385 390 395 400 Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 405 410 415 Arg Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 420 425 430
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 435
440 445 Leu Ser Leu Ser Pro Gly Lys 450 455 <210> SEQ ID NO
237 <211> LENGTH: 213 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 237 Gln Leu Thr Gln
Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 1 5 10 15 Val Thr
Ile Thr Cys Arg Ala Ser Gln Gly Leu Ser Ser Ala Leu Ala 20 25 30
Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp 35
40 45 Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
Gly 50 55 60 Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
Pro Glu Asp 65 70 75 80 Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser
Tyr Pro Gln Ile Thr 85 90 95 Phe Gly Gln Gly Thr Arg Leu Glu Ile
Lys Arg Thr Val Ala Ala Pro 100 105 110 Ser Val Phe Ile Phe Pro Pro
Ser Asp Glu Gln Leu Lys Ser Gly Thr 115 120 125 Ala Ser Val Val Cys
Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 130 135 140 Val Gln Trp
Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 145 150 155 160
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 165
170 175 Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
Ala 180 185 190 Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
Lys Ser Phe 195 200 205 Asn Arg Gly Glu Cys 210 <210> SEQ ID
NO 238 <211> LENGTH: 15 <212> TYPE: PRT <213>
ORGANISM: Homo Sapiens <400> SEQUENCE: 238 Pro Glu Phe Arg
Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe 1 5 10 15 <210>
SEQ ID NO 239 <211> LENGTH: 16 <212> TYPE: PRT
<213> ORGANISM: Homo Sapiens <400> SEQUENCE: 239 Phe
Ala Gln Ser Lys Pro Asp Ser Ala Glu Pro Met Asp Arg Ser Ala 1 5 10
15 <210> SEQ ID NO 240 <211> LENGTH: 16 <212>
TYPE: PRT <213> ORGANISM: Homo Sapiens <400> SEQUENCE:
240 Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser Leu Asn Asp Asp
1 5 10 15
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