U.S. patent application number 15/850094 was filed with the patent office on 2018-08-16 for apparatus, compositions, and methods for assessment of chronic obstructive pulmonary disease progression among rapid and slow decline conditions. The applicant listed for this patent is Lineagen, Inc., University of Utah Research Foundation. Invention is credited to Robert Mark Gritz, John Hoidal, Mark F. Leppert, Michael S. Paul, Joel Gardner Pounds, Mary Beth Scholand, Richard Dale Smith.
Application Number | 20180230542 15/850094 |
Document ID | / |
Family ID | 38846566 |
Filed Date | 2018-08-16 |
United States Patent Application | 20180230542 |
Kind Code | A1 |
Hoidal; John ; et al. | August 16, 2018 |
Methods are disclosed for generating and isolating an informative content repository of respiratory related biomarkers to accurately determine whether an individual has normal or abnormal pulmonary function. Specifically, methods are directed to determination of whether individuals have chronic obstructive pulmonary disease, and if so, whether the affected individuals experience rapid long decline or slow lung decline as a result of COPD. Also disclosed is an informative content repository of chronic obstructive pulmonary disease biomarkers, which when linked with other informative content provides a powerful tool for diagnosis, study, therapeutic discovery and development, condition management, health maintenance, and linking chronic obstructive pulmonary disease through pattern of life style, environmental exposure, and genetic susceptibility and inheritance. Disclosed herein is a chronic obstructive pulmonary disease biomarker informative content repository comprising at least one COPD biomarker, apparatus and methods to diagnose, assess, address, and ameliorate related conditions.
Inventors: | Hoidal; John; (Salt Lake City, UT) ; Scholand; Mary Beth; (Salt Lake City, UT) ; Leppert; Mark F.; (Salt Lake City, UT) ; Paul; Michael S.; (Salt Lake City, UT) ; Gritz; Robert Mark; (Fairfax, VA) ; Pounds; Joel Gardner; (Richland, WA) ; Smith; Richard Dale; (Richland, WA) | ||||||||||
Applicant: |
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Family ID: | 38846566 | ||||||||||
Appl. No.: | 15/850094 | ||||||||||
Filed: | December 21, 2017 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
11770074 | Jun 28, 2007 | 9885085 | ||
15850094 | ||||
60817316 | Jun 28, 2006 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | G01N 33/6848 20130101; G16B 20/00 20190201; G01N 2800/122 20130101; C12Q 1/6883 20130101 |
International Class: | C12Q 1/6883 20180101 C12Q001/6883; G01N 33/68 20060101 G01N033/68 |
Sequence CWU 1
1
343122PRTHomo sapiens 1Arg Asn Pro Phe Val Phe Ala Pro Thr Leu Leu
Thr Val Ala Val His 1 5 10 15 Phe Glu Glu Val Ala Lys 20 28PRTHomo
sapiens 2Asp Asp Asn Pro Asn Leu Pro Arg 1 5 37PRTHomo sapiens 3Glu
Phe Ala Glu Val Ser Lys 1 5 49PRTHomo sapiens 4Lys Asp Leu Gly Glu
Glu Asn Phe Lys 1 5 57PRTHomo sapiens 5Leu Ser Gln Arg Phe Pro Lys
1 5 611PRTHomo sapiens 6Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu
1 5 10 710PRTHomo sapiens 7Leu Val Asn Glu Val Thr Glu Phe Ala Lys
1 5 10 819PRTHomo sapiens 8Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu
Gly Met Phe Leu Tyr Glu 1 5 10 15 Tyr Ala Arg 98PRTHomo sapiens
9Thr Tyr Glu Thr Thr Leu Glu Lys 1 5 1020PRTHomo sapiens 10Gly Ala
Ala Ala Asn Leu Glu Leu Ile Phe Val Gly Pro Gln His Ala 1 5 10 15
Gly Asn Tyr Arg 20 119PRTHomo sapiens 11Gly Glu Lys Glu Leu Leu Val
Pro Arg 1 5 1237PRTHomo sapiens 12Leu His Asp Asn Gln Asn Gly Trp
Ser Gly Asp Ser Ala Pro Val Glu 1 5 10 15 Leu Ile Leu Ser Asp Glu
Thr Leu Pro Ala Pro Glu Phe Ser Pro Glu 20 25 30 Pro Glu Ser Gly
Arg 35 1312PRTHomo sapiens 13Ser Gly Leu Ser Thr Gly Trp Thr Gln
Leu Ser Lys 1 5 10 1420PRTHomo sapiens 14Ser Leu Pro Ala Pro Trp
Leu Ser Met Ala Pro Val Ser Trp Ile Thr 1 5 10 15 Pro Gly Leu Lys
20 1517PRTHomo sapiens 15Val Thr Leu Thr Cys Val Ala Pro Leu Ser
Gly Val Asp Phe Gln Leu 1 5 10 15 Arg 1618PRTHomo sapiens 16Leu Tyr
Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala 1 5 10 15
Ala Lys 1714PRTHomo sapiens 17Trp Glu Met Pro Phe Asp Pro Gln Asp
Thr His Gln Ser Arg 1 5 10 1819PRTHomo sapiens 18Ala Ser Val Ser
Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln Asn 1 5 10 15 Thr Gln
Asn 1930PRTHomo sapiens 19Gly Gly Val Glu Asp Glu Val Thr Leu Ser
Ala Tyr Ile Thr Ile Ala 1 5 10 15 Leu Leu Glu Ile Pro Leu Thr Val
Thr His Pro Val Val Arg 20 25 30 208PRTHomo sapiens 20Gly Pro Thr
Gln Glu Phe Lys Lys 1 5 2118PRTHomo sapiens 21Leu Leu Leu Gln Gln
Val Ser Leu Pro Glu Leu Pro Gly Glu Tyr Ser 1 5 10 15 Met Lys
2212PRTHomo sapiens 22Gln Glu Gly Asp His Gly Ser His Val Tyr Thr
Lys 1 5 10 2311PRTHomo sapiens 23Val Gly Phe Tyr Glu Ser Asp Val
Met Gly Arg 1 5 10 2419PRTHomo sapiens 24Asp Ser Phe His Leu Asp
Glu Gln Phe Thr Val Pro Val Glu Met Met 1 5 10 15 Gln Ala Arg
2533PRTHomo sapiens 25Glu Ala Thr Glu Gly Lys Ile Gln Glu Phe Leu
Ser Gly Leu Pro Glu 1 5 10 15 Asp Thr Val Leu Leu Leu Leu Asn Ala
Ile His Phe Gln Gly Phe Trp 20 25 30 Arg 2623PRTHomo sapiens 26Glu
Leu Lys Glu Gln Gln Asp Ser Pro Gly Asn Lys Asp Phe Leu Gln 1 5 10
15 Ser Leu Lys Gly Phe Pro Arg 20 2739PRTHomo sapiens 27Gly Phe Pro
Ile Lys Glu Asp Phe Leu Glu Gln Ser Glu Gln Leu Phe 1 5 10 15 Gly
Ala Lys Pro Val Ser Leu Thr Gly Lys Gln Glu Asp Asp Leu Ala 20 25
30 Asn Ile Asn Gln Trp Val Lys 35 2827PRTHomo sapiens 28Ile Gln Glu
Phe Leu Ser Gly Leu Pro Glu Asp Thr Val Leu Leu Leu 1 5 10 15 Leu
Asn Ala Ile His Phe Gln Gly Phe Trp Arg 20 25 298PRTHomo sapiens
29Asn Pro Asn Pro Ser Ala Pro Arg 1 5 3014PRTHomo sapiens 30Pro Pro
Met Glu Glu Asp Tyr Pro Gln Phe Gly Ser Pro Lys 1 5 10 3114PRTHomo
sapiens 31Pro Lys Asp Pro Thr Phe Ile Pro Ala Pro Ile Gln Ala Lys 1
5 10 3220PRTHomo sapiens 32Gln Lys Leu His Glu Leu Gln Glu Lys Leu
Ser Pro Leu Gly Glu Glu 1 5 10 15 Met Arg Asp Arg 20 3316PRTHomo
sapiens 33Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu
Gly Lys 1 5 10 15 3421PRTHomo sapiens 34Ala Gly Thr Glu Leu Val Asn
Phe Leu Ser Tyr Phe Val Glu Leu Gly 1 5 10 15 Thr Gln Pro Ala Thr
20 3522PRTHomo sapiens 35Ala Gly Thr Glu Leu Val Asn Phe Leu Ser
Tyr Phe Val Glu Leu Gly 1 5 10 15 Thr Gln Pro Ala Thr Gln 20
3611PRTHomo sapiens 36Ile Asp Gln Asn Val Glu Glu Leu Lys Gly Arg 1
5 10 3712PRTHomo sapiens 37Lys Leu Val Pro Phe Ala Thr Glu Leu His
Glu Arg 1 5 10 3821PRTHomo sapiens 38Leu Thr Pro Tyr Ala Asp Glu
Phe Lys Val Lys Ile Asp Gln Thr Val 1 5 10 15 Glu Glu Leu Arg Arg
20 399PRTHomo sapiens 39Pro Phe Ala Thr Glu Leu His Glu Arg 1 5
407PRTHomo sapiens 40Pro Tyr Ala Asp Glu Phe Lys 1 5 4117PRTHomo
sapiens 41Ser Leu Ala Glu Leu Gly Gly His Leu Asp Gln Gln Val Glu
Glu Phe 1 5 10 15 Arg 4218PRTHomo sapiens 42Ser Leu Ala Glu Leu Gly
Gly His Leu Asp Gln Gln Val Glu Glu Phe 1 5 10 15 Arg Arg
4315PRTHomo sapiens 43Ala Leu Tyr Trp Val Asn Gly Gln Val Pro Asp
Gly Val Ser Lys 1 5 10 15 4411PRTHomo sapiens 44Asp Leu Lys Val Glu
Asp Ile Pro Leu Ala Arg 1 5 10 4511PRTHomo sapiens 45Glu Phe Gln
Val Pro Thr Phe Thr Ile Pro Lys 1 5 10 467PRTHomo sapiens 46Phe Ile
Ile Pro Ser Pro Lys 1 5 4713PRTHomo sapiens 47Phe Leu Asp Ser Asn
Ile Lys Phe Ser His Val Glu Lys 1 5 10 4818PRTHomo sapiens 48Phe
Ser Val Pro Ala Gly Ile Val Ile Pro Ser Phe Gln Ala Leu Thr 1 5 10
15 Ala Arg 4913PRTHomo sapiens 49Ile Ala Glu Leu Ser Ala Thr Ala
Gln Glu Ile Ile Lys 1 5 10 5010PRTHomo sapiens 50Ile Glu Ile Pro
Leu Pro Phe Gly Gly Lys 1 5 10 5118PRTHomo sapiens 51Ile His Ser
Gly Ser Phe Gln Ser Gln Val Glu Leu Ser Asn Asp Gln 1 5 10 15 Glu
Lys 5220PRTHomo sapiens 52Ile Thr Glu Asn Asp Ile Gln Ile Ala Leu
Asp Asp Ala Lys Ile Asn 1 5 10 15 Phe Asn Glu Lys 20 5319PRTHomo
sapiens 53Leu Leu Leu Gln Met Asp Ser Ser Ala Thr Ala Tyr Gly Ser
Thr Val 1 5 10 15 Ser Lys Arg 549PRTHomo sapiens 54Leu Thr Ile Phe
Lys Thr Glu Leu Arg 1 5 558PRTHomo sapiens 55Leu Thr Leu Asp Ile
Gln Asn Lys 1 5 5612PRTHomo sapiens 56Met Asn Phe Lys Gln Glu Leu
Asn Gly Asn Thr Lys 1 5 10 5715PRTHomo sapiens 57Asn Leu Gln Asn
Asn Ala Glu Trp Val Tyr Gln Gly Ala Ile Arg 1 5 10 15 5823PRTHomo
sapiens 58Asn Ser Leu Phe Phe Ser Ala Gln Pro Phe Glu Ile Thr Ala
Ser Thr 1 5 10 15 Asn Asn Glu Gly Asn Leu Lys 20 5910PRTHomo
sapiens 59Gln Gly Phe Phe Pro Asp Ser Val Asn Lys 1 5 10
6019PRTHomo sapiens 60Gln Val Phe Leu Tyr Pro Glu Lys Asp Glu Pro
Thr Tyr Ile Leu Asn 1 5 10 15 Ile Lys Arg 6116PRTHomo sapiens 61Arg
Asn Leu Gln Asn Asn Ala Glu Trp Val Tyr Gln Gly Ala Ile Arg 1 5 10
15 627PRTHomo sapiens 62Ser Gln Ala Ile Ala Thr Lys 1 5 6313PRTHomo
sapiens 63Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys 1 5
10 6413PRTHomo sapiens 64Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala
Met Ser Arg 1 5 10 6514PRTHomo sapiens 65Val Leu Leu Asp Gln Leu
Gly Thr Thr Ile Ser Phe Glu Arg 1 5 10 6611PRTHomo sapiens 66Val
Arg Glu Ser Asp Glu Glu Thr Gln Ile Lys 1 5 10 679PRTHomo sapiens
67Val Ser Thr Ala Phe Val Tyr Thr Lys 1 5 6821PRTHomo sapiens 68Asp
Val Ser Ser Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu 1 5 10
15 Glu Asp Lys Ala Arg 20 699PRTHomo sapiens 69Leu Gln Ala Glu Ala
Phe Gln Ala Arg 1 5 7010PRTHomo sapiens 70Lys Ala Thr Val Val Tyr
Gln Gly Glu Arg 1 5 10 7117PRTHomo sapiens 71Thr Ser Ile Tyr Pro
Phe Leu Asp Phe Met Pro Ser Pro Gln Val Val 1 5 10 15 Arg
7210PRTHomo sapiens 72Val Gly Glu Ala Asn Pro Lys Leu Gln Lys 1 5
10 7315PRTHomo sapiens 73Glu Ala Leu Ile Gln Phe Leu Glu Gln Val
His Gln Gly Ile Lys 1 5 10 15 7422PRTHomo sapiens 74His Leu Tyr Val
Leu Glu Phe Ser Asp His Pro Gly Ile His Glu Pro 1 5 10 15 Leu Glu
Pro Glu Val Lys 20 7520PRTHomo sapiens 75Lys Leu Ile Ser Val Asp
Thr Glu His Ser Asn Ile Tyr Leu Gln Asn 1 5 10 15 Gly Pro Asp Arg
20 7642PRTHomo sapiens 76Met Phe Gly Asn Leu Gln Gly Leu Thr Met
His Val Gly Asp Glu Val 1 5 10 15 Asn Trp Tyr Leu Met Gly Met Gly
Asn Glu Ile Asp Leu His Thr Val 20 25 30 His Phe His Gly His Ser
Phe Gln Tyr Lys 35 40 7721PRTHomo sapiens 77Met Tyr Tyr Ser Ala Val
Asp Pro Thr Lys Asp Ile Phe Thr Gly Leu 1 5 10 15 Ile Gly Pro Met
Lys 20 7810PRTHomo sapiens 78Pro Leu Ser Ile Glu Pro Ile Gly Val
Arg 1 5 10 7913PRTHomo sapiens 79Gln Tyr Thr Asp Ser Thr Phe Arg
Val Pro Val Glu Arg 1 5 10 8017PRTHomo sapiens 80Thr Thr Ile Glu
Lys Pro Val Trp Leu Gly Phe Leu Gly Pro Ile Ile 1 5 10 15 Lys
8110PRTHomo sapiens 81Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys 1 5
10 8220PRTHomo sapiens 82Ile Val Glu Gly Ser Asp Ala Glu Ile Gly
Met Ser Pro Trp Gln Val 1 5 10 15 Met Leu Phe Arg 20 8313PRTHomo
sapiens 83Thr Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asn Pro Arg 1 5
10 8417PRTHomo sapiens 84Val Thr Gly Trp Gly Asn Leu Lys Glu Thr
Trp Thr Ala Asn Val Gly 1 5 10 15 Lys 8511PRTHomo sapiens 85Trp Ile
Gln Lys Val Ile Asp Gln Phe Gly Glu 1 5 10 869PRTHomo sapiens 86Thr
Gly Ile Val Ser Gly Phe Gly Arg 1 5 8710PRTHomo sapiens 87Phe Gln
Pro Thr Leu Leu Thr Leu Pro Arg 1 5 10 888PRTHomo sapiens 88Pro Thr
Leu Leu Thr Leu Pro Arg 1 5 8915PRTHomo sapiens 89Met Gly Asn Phe
Pro Trp Gln Val Phe Thr Asn Ile His Gly Arg 1 5 10 15 9040PRTHomo
sapiens 90Ser Val Leu Leu Ala Gln Glu Leu Pro Gln Gln Leu Thr Ser
Pro Gly 1 5 10 15 Tyr Pro Glu Pro Tyr Gly Lys Gly Gln Glu Ser Ser
Thr Asp Ile Lys 20 25 30 Ala Pro Glu Gly Phe Ala Val Arg 35 40
9119PRTHomo sapiens 91Ser Ser Asn Asn Pro His Ser Pro Ile Val Glu
Glu Phe Gln Val Pro 1 5 10 15 Tyr Asn Lys 9214PRTHomo sapiens 92Ala
Leu His Gln Val Phe Glu His Met Leu Asp Val Ser Lys 1 5 10
9312PRTHomo sapiens 93Gln His Leu Gly Asp Val Leu Asn Phe Leu Pro
Leu 1 5 10 9414PRTHomo sapiens 94Ala Gly Asp Phe Leu Glu Ala Asn
Tyr Met Asn Leu Gln Arg 1 5 10 957PRTHomo sapiens 95Ala Val Leu Tyr
Asn Tyr Arg 1 5 9618PRTHomo sapiens 96Ala Tyr Tyr Glu Asn Ser Pro
Gln Gln Val Phe Ser Thr Glu Phe Glu 1 5 10 15 Val Lys 9732PRTHomo
sapiens 97His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser
Val Pro 1 5 10 15 Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu
Val Glu Val Lys 20 25 30 9814PRTHomo sapiens 98Ile Pro Ile Glu Asp
Gly Ser Gly Glu Val Val Leu Ser Arg 1 5 10 997PRTHomo sapiens 99Leu
Met Asn Ile Phe Leu Lys 1 5 10024PRTHomo sapiens 100Leu Met Asn Ile
Phe Leu Lys Asp Ser Ile Thr Thr Trp Glu Ile Leu 1 5 10 15 Ala Val
Ser Met Ser Asp Lys Lys 20 1018PRTHomo sapiens 101Pro Gly Gln Gln
Met Thr Leu Lys 1 5 10216PRTHomo sapiens 102Pro Leu Ser Trp Asp Ile
Pro Glu Leu Val Asn Met Gly Gln Trp Lys 1 5 10 15 10311PRTHomo
sapiens 103Gln Glu Leu Ser Glu Ala Glu Gln Ala Thr Arg 1 5 10
1048PRTHomo sapiens 104Gln Gly Ala Leu Glu Leu Ile Lys 1 5
10523PRTHomo sapiens 105Gln Lys Pro Asp Gly Val Phe Gln Glu Asp Ala
Pro Val Ile His Gln 1 5 10 15 Glu Met Ile Gly Gly Leu Arg 20
10629PRTHomo sapiens 106Gln Leu Tyr Asn Val Glu Ala Thr Ser Tyr Ala
Leu Leu Ala Leu Leu 1 5 10 15 Gln Leu Lys Asp Phe Asp Phe Val Pro
Pro Val Val Arg 20 25 10710PRTHomo sapiens 107Ser Asp Asp Lys Val
Thr Leu Glu Glu Arg 1 5 10 10813PRTHomo sapiens 108Ser Asp Asp Lys
Val Thr Leu Glu Glu Arg Leu Asp Lys 1 5 10 10918PRTHomo sapiens
109Ser Gly Gln Ser Glu Asp Arg Gln Pro Val Pro Gly Gln Gln Met Thr
1 5 10 15 Leu Lys 11010PRTHomo sapiens 110Ser Leu Lys Val Val Pro
Glu Gly Ile Arg 1 5 10 11116PRTHomo sapiens 111Ser Asn Leu Asp Glu
Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg 1 5 10 15 11213PRTHomo
sapiens 112Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn Ile Leu Arg 1 5
10 11316PRTHomo sapiens 113Ser Tyr Thr Val Ala Ile Ala Gly Tyr Ala
Leu Ala Gln Met Gly Arg 1 5 10 15 11416PRTHomo sapiens 114Val His
Gln Tyr Phe Asn Val Glu Leu Ile Gln Pro Gly Ala Val Lys 1 5 10 15
11510PRTHomo sapiens 115Leu Asn Asn Gly Glu Ile Thr Gln His Arg 1 5
10 1169PRTHomo sapiens 116Asp His Ala Val Asp Leu Ile Gln Lys 1 5
11710PRTHomo sapiens 117Phe Gly Leu Leu Asp Glu Asp Gly Lys Lys 1 5
10 11838PRTHomo sapiens 118Gly Ser Phe Glu Phe Pro Val Gly Asp Ala
Val Ser Lys Val Leu Gln 1 5 10 15 Ile Glu Lys Glu Gly Ala Ile His
Arg Glu Glu Leu Val Tyr Glu Leu 20 25 30 Asn Pro Leu Asp His Arg 35
11927PRTHomo sapiens 119Lys Lys Glu Val Tyr Met Pro Ser Ser Ile Phe
Gln Asp Asp Phe Val 1 5 10 15 Ile Pro Asp Ile Ser Glu Pro Gly Thr
Trp Lys 20 25 12036PRTHomo sapiens 120Leu Tyr Val Ala Ala Ala Ile
Ile Glu Ser Pro Gly Gly Glu Met Glu 1 5 10 15 Glu Ala Glu Leu Thr
Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser Leu 20 25 30 Asp Leu Ser
Lys 35 12141PRTHomo sapiens 121Ser Met Gln Gly Gly Leu Val Gly Asn
Asp Glu Thr Val Ala Leu Thr 1 5 10 15 Ala Phe Val Thr Ile Ala Leu
His His Gly Leu Ala Val Phe Gln Asp 20 25 30 Glu Gly Ala Glu Pro
Leu Lys Gln Arg 35 40 12223PRTHomo sapiens 122Thr Leu Glu Ile Pro
Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly 1 5 10 15 Asp Phe Asn
Ser Tyr Val Arg 20
12310PRTHomo sapiens 123Val Gly Asp Thr Leu Asn Leu Asn Leu Arg 1 5
10 12425PRTHomo sapiens 124Val Leu Gln Ile Glu Lys Glu Gly Ala Ile
His Arg Glu Glu Leu Val 1 5 10 15 Tyr Glu Leu Asn Pro Leu Asp His
Arg 20 25 12526PRTHomo sapiens 125Val Thr Ala Ser Asp Pro Leu Asp
Thr Leu Gly Ser Glu Gly Ala Leu 1 5 10 15 Ser Pro Gly Gly Val Ala
Ser Leu Leu Arg 20 25 1269PRTHomo sapiens 126Tyr Arg Val Phe Ala
Leu Asp Gln Lys 1 5 1279PRTHomo sapiens 127Tyr Val Leu Pro Asn Phe
Glu Val Lys 1 5 12824PRTHomo sapiens 128Glu Lys Phe Ser Asp Ala Ser
Tyr Gln Ser Ile Asn Ile Pro Val Thr 1 5 10 15 Gln Asn Met Val Pro
Ser Ser Arg 20 12922PRTHomo sapiens 129Phe Ser Asp Ala Ser Tyr Gln
Ser Ile Asn Ile Pro Val Thr Gln Asn 1 5 10 15 Met Val Pro Ser Ser
Arg 20 13014PRTHomo sapiens 130Lys Gln Thr Ala Cys Lys Pro Glu Ile
Ala Tyr Ala Tyr Lys 1 5 10 13111PRTHomo sapiens 131Thr Leu Leu Pro
Val Ser Lys Pro Glu Ile Arg 1 5 10 13212PRTHomo sapiens 132Ala Lys
Asp Leu His Leu Ser Asp Val Phe Leu Lys 1 5 10 13315PRTHomo sapiens
133Leu Ser Glu Lys His Glu Gly Ser Phe Ile Gln Gly Ala Glu Lys 1 5
10 15 13428PRTHomo sapiens 134Thr Phe Ser Glu Trp Leu Glu Ser Val
Lys Glu Asn Pro Ala Val Ile 1 5 10 15 Asp Phe Glu Leu Ala Pro Ile
Val Asp Leu Val Arg 20 25 13514PRTHomo sapiens 135Ser Arg Glu Cys
Asn Asn Pro Pro Pro Ser Gly Gly Gly Arg 1 5 10 13616PRTHomo sapiens
136Tyr Ser Ala Trp Ala Glu Ser Val Thr Asn Leu Pro Gln Val Ile Lys
1 5 10 15 13710PRTHomo sapiens 137Ala Met Ala Val Glu Asp Ile Ile
Ser Arg 1 5 10 13815PRTHomo sapiens 138Gln Lys Ile Ser Glu Gly Leu
Pro Ala Leu Glu Phe Pro Asn Glu 1 5 10 15 1398PRTHomo sapiens
139Tyr Ala Phe Glu Leu Lys Glu Lys 1 5 14010PRTHomo sapiens 140Ala
Leu Phe Val Ser Glu Glu Glu Lys Lys 1 5 10 1419PRTHomo sapiens
141Asp Ile Ser Glu Val Val Thr Pro Arg 1 5 14211PRTHomo sapiens
142Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 1 5 10 14332PRTHomo
sapiens 143His Val Ile Ile Leu Met Thr Asp Gly Leu His Asn Met Gly
Gly Asp 1 5 10 15 Pro Ile Thr Val Ile Asp Glu Ile Arg Asp Leu Leu
Tyr Ile Gly Lys 20 25 30 14414PRTHomo sapiens 144Val Ser Glu Ala
Asp Ser Ser Asn Ala Asp Trp Val Thr Lys 1 5 10 14534PRTHomo sapiens
145Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr Lys Gln Leu
1 5 10 15 Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly Thr
Asn Thr 20 25 30 Lys Lys 1468PRTHomo sapiens 146Val Ser Val Gly Gly
Glu Lys Arg 1 5 1479PRTHomo sapiens 147Glu Phe Asp His Asn Ser Asn
Ile Arg 1 5 1489PRTHomo sapiens 148Ile Asp Val His Leu Val Pro Asp
Arg 1 5 1497PRTHomo sapiens 149Asn Asp Phe Thr Trp Phe Lys 1 5
15019PRTHomo sapiens 150Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu
Gly Gly Gly Val Arg 1 5 10 15 Gly Pro Arg 15120PRTHomo sapiens
151Glu Val Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln
1 5 10 15 Val Ile Ala Lys 20 15216PRTHomo sapiens 152Gly Leu Ile
Asp Glu Val Asn Gln Asp Phe Thr Asn Arg Ile Asn Lys 1 5 10 15
15313PRTHomo sapiens 153Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile
Thr Arg 1 5 10 15413PRTHomo sapiens 154Met Lys Pro Val Pro Asp Leu
Val Pro Gly Asn Phe Lys 1 5 10 15511PRTHomo sapiens 155Pro Val Pro
Asp Leu Val Pro Gly Asn Phe Lys 1 5 10 15610PRTHomo sapiens 156Val
Thr Ser Gly Ser Thr Thr Thr Thr Arg 1 5 10 15720PRTHomo sapiens
157Gly Gly Glu Thr Ser Glu Met Tyr Leu Ile Gln Pro Asp Ser Ser Val
1 5 10 15 Lys Pro Tyr Arg 20 1588PRTHomo sapiens 158Ile Arg Pro Phe
Phe Pro Gln Gln 1 5 15921PRTHomo sapiens 159Lys Gly Gly Glu Thr Ser
Glu Met Tyr Leu Ile Gln Pro Asp Ser Ser 1 5 10 15 Val Lys Pro Tyr
Arg 20 16019PRTHomo sapiens 160Lys Trp Asp Pro Tyr Lys Gln Gly Phe
Gly Asn Val Ala Thr Asn Thr 1 5 10 15 Asp Gly Lys 1617PRTHomo
sapiens 161Ser Ile Leu Glu Asn Leu Arg 1 5 16226PRTHomo sapiens
162Thr Met Thr Ile His Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp
1 5 10 15 Asn Asp Gly Trp Leu Thr Ser Asp Pro Arg 20 25
16327PRTHomo sapiens 163Thr Met Thr Ile His Asn Gly Met Phe Phe Ser
Thr Tyr Asp Arg Asp 1 5 10 15 Asn Asp Gly Trp Leu Thr Ser Asp Pro
Arg Lys 20 25 16418PRTHomo sapiens 164Trp Asp Pro Tyr Lys Gln Gly
Phe Gly Asn Val Ala Thr Asn Thr Asp 1 5 10 15 Gly Lys 16513PRTHomo
sapiens 165Tyr Tyr Trp Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys 1 5
10 16615PRTHomo sapiens 166Ile His Leu Ile Ser Thr Gln Ser Ala Ile
Pro Tyr Ala Leu Arg 1 5 10 15 16710PRTHomo sapiens 167Pro Asn Met
Ile Asp Ala Ala Thr Leu Lys 1 5 10 1688PRTHomo sapiens 168Thr Ala
Asp Tyr Ala Met Phe Lys 1 5 16919PRTHomo sapiens 169Thr Tyr Asn Pro
Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala 1 5 10 15 Thr Leu
Lys 17018PRTHomo sapiens 170Tyr Asn Pro Asp Glu Ser Ser Lys Pro Asn
Met Ile Asp Ala Ala Thr 1 5 10 15 Leu Lys 17116PRTHomo sapiens
171Gly Ala Thr Tyr Asn Ile Ile Val Glu Ala Leu Lys Asp Gln Gln Arg
1 5 10 15 17222PRTHomo sapiens 172Thr Glu Ile Asp Lys Pro Ser Gln
Met Gln Val Thr Asp Val Gln Asp 1 5 10 15 Asn Ser Ile Ser Val Lys
20 17340PRTHomo sapiens 173Thr Pro Phe Val Thr His Pro Gly Tyr Asp
Thr Gly Asn Gly Ile Gln 1 5 10 15 Leu Pro Gly Thr Ser Gly Gln Gln
Pro Ser Val Gly Gln Gln Met Ile 20 25 30 Phe Glu Glu His Gly Phe
Arg Arg 35 40 17413PRTHomo sapiens 174Ala Gly Ala Leu Asn Ser Asn
Asp Ala Phe Val Leu Lys 1 5 10 17522PRTHomo sapiens 175Ala Gln Pro
Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly Phe Trp 1 5 10 15 Glu
Ala Leu Gly Gly Lys 20 17630PRTHomo sapiens 176Ile Glu Gly Ser Asn
Lys Val Pro Val Asp Pro Ala Thr Tyr Gly Gln 1 5 10 15 Phe Tyr Gly
Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr Arg 20 25 30 17720PRTHomo
sapiens 177Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly Phe Trp
Glu Ala 1 5 10 15 Leu Gly Gly Lys 20 17817PRTHomo sapiens 178Gln
Thr Gln Val Ser Val Leu Pro Glu Gly Gly Glu Thr Pro Leu Phe 1 5 10
15 Lys 1798PRTHomo sapiens 179Arg Thr Pro Ile Thr Val Val Lys 1 5
1808PRTHomo sapiens 180Thr Ala Ser Asp Phe Ile Thr Lys 1 5
18128PRTHomo sapiens 181Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr
Ser Asp Asn His Gly 1 5 10 15 Ala Thr Tyr Ala Phe Ser Gly Thr His
Tyr Trp Arg 20 25 18212PRTHomo sapiens 182Asp Val Arg Asp Tyr Phe
Met Pro Cys Pro Gly Arg 1 5 10 1836PRTHomo sapiens 183Glu Lys Gly
Tyr Pro Lys 1 5 1849PRTHomo sapiens 184Val Trp Val Tyr Pro Pro Glu
Lys Lys 1 5 18515PRTHomo sapiens 185Phe Thr Val Asp Arg Pro Phe Leu
Phe Leu Ile Tyr Glu His Arg 1 5 10 15 1867PRTHomo sapiens 186Leu
Asn Ile Leu Asn Ala Lys 1 5 1878PRTHomo sapiens 187Thr Arg Glu Val
Leu Leu Pro Lys 1 5 18810PRTHomo sapiens 188Val Phe Ser Leu Gln Trp
Gly Glu Val Lys 1 5 10 1897PRTHomo sapiens 189His Leu Ser Asp Leu
Cys Lys 1 5 19012PRTHomo sapiens 190Ala Ala Ile Ser Gly Glu Asn Ala
Gly Leu Val Arg 1 5 10 19118PRTHomo sapiens 191Phe Ala His Tyr Val
Val Thr Ser Gln Val Val Asn Thr Ala Asn Glu 1 5 10 15 Ala Arg
19228PRTHomo sapiens 192Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr
Ile Asp Lys Pro Ser 1 5 10 15 Glu Asp Ser Pro Pro Leu Glu Met Leu
Gly Pro Arg 20 25 19313PRTHomo sapiens 193Lys Ala Ala Ile Ser Gly
Glu Asn Ala Gly Leu Val Arg 1 5 10 19410PRTHomo sapiens 194Leu Asp
Ala Gln Ala Ser Phe Leu Pro Lys 1 5 10 19513PRTHomo sapiens 195Gln
Ala Val Asp Thr Ala Val Asp Gly Val Phe Ile Arg 1 5 10 1968PRTHomo
sapiens 196Ala Thr Thr Met Ile Gln Ser Lys 1 5 19710PRTHomo sapiens
197Asp Lys His Ala Asp Pro Asp Phe Thr Arg 1 5 10 19815PRTHomo
sapiens 198Ile Gln Pro Ser Gly Gly Thr Asn Ile Asn Glu Ala Leu Leu
Arg 1 5 10 15 19912PRTHomo sapiens 199Ile Tyr Gly Asn Gln Asp Thr
Ser Ser Gln Leu Lys 1 5 10 20013PRTHomo sapiens 200Ile Tyr Gly Asn
Gln Asp Thr Ser Ser Gln Leu Lys Lys 1 5 10 2017PRTHomo sapiens
201Ile Tyr Leu Gln Pro Gly Arg 1 5 20214PRTHomo sapiens 202Leu Trp
Ala Tyr Leu Thr Ile Asn Gln Leu Leu Ala Glu Arg 1 5 10 2039PRTHomo
sapiens 203Met Lys Gln Thr Val Glu Ala Met Lys 1 5 2047PRTHomo
sapiens 204Gln Thr Val Glu Ala Met Lys 1 5 20522PRTHomo sapiens
205Thr Ile Leu Asp Asp Leu Arg Ala Glu Asp His Phe Ser Val Ile Asp
1 5 10 15 Phe Asn Gln Asn Ile Arg 20 20635PRTHomo sapiens 206His
Phe Glu Ile Glu Val Asp Ile Phe Glu Pro Gln Gly Ile Ser Met 1 5 10
15 Leu Asp Ala Glu Ala Ser Phe Ile Thr Asn Asp Leu Leu Gly Ser Ala
20 25 30 Leu Thr Lys 35 20715PRTHomo sapiens 207Ala Asn Thr Val Gln
Glu Ala Thr Phe Gln Met Glu Leu Pro Lys 1 5 10 15 2089PRTHomo
sapiens 208Leu Gly Val Tyr Glu Leu Leu Leu Lys 1 5 20916PRTHomo
sapiens 209Leu Gln Asp Arg Gly Pro Asp Val Leu Thr Ala Thr Val Ser
Gly Lys 1 5 10 15 21016PRTHomo sapiens 210Asn Met Glu Gln Phe Gln
Val Ser Val Ser Val Ala Pro Asn Ala Lys 1 5 10 15 21124PRTHomo
sapiens 211Gln Gly Pro Val Asn Leu Leu Ser Asp Pro Glu Gln Gly Val
Glu Val 1 5 10 15 Thr Gly Gln Tyr Glu Arg Glu Lys 20 21220PRTHomo
sapiens 212Gln Leu Gly Leu Pro Gly Pro Pro Asp Val Pro Asp His Ala
Ala Tyr 1 5 10 15 His Pro Phe Arg 20 21321PRTHomo sapiens 213Gln
Leu Gly Leu Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala Tyr 1 5 10
15 His Pro Phe Arg Arg 20 21410PRTHomo sapiens 214Arg Leu Gly Val
Tyr Glu Leu Leu Leu Lys 1 5 10 21510PRTHomo sapiens 215Val Gln Gly
Asn Asp His Ser Ala Thr Arg 1 5 10 2169PRTHomo sapiens 216Tyr Ile
Phe His Asn Phe Met Glu Arg 1 5 2177PRTHomo sapiens 217Tyr Tyr Leu
Gln Gly Ala Lys 1 5 21811PRTHomo sapiens 218Ala Val Glu Gln Val Lys
Asn Ala Phe Asn Lys 1 5 10 21932PRTHomo sapiens 219Asn Ala Phe Asn
Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser 1 5 10 15 Glu Phe
Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys 20 25 30
2209PRTHomo sapiens 220Gln Val Val Ala Gly Leu Asn Phe Arg 1 5
2217PRTHomo sapiens 221Val Gln Val Val Ala Gly Lys 1 5 2228PRTHomo
sapiens 222Phe Asn Ala Leu Gln Tyr Leu Arg 1 5 22311PRTHomo sapiens
223Leu Lys Glu Asp Ala Val Ser Ala Ala Phe Lys 1 5 10 2247PRTHomo
sapiens 224Ile Ala Leu Asp Phe Leu Lys 1 5 22529PRTHomo sapiens
225Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu
1 5 10 15 Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys 20 25
22617PRTHomo sapiens 226Pro Ser Leu Ser His Leu Leu Ser Gln Tyr Tyr
Gly Ala Gly Val Ala 1 5 10 15 Arg 22724PRTHomo sapiens 227Ser Leu
Pro Leu Leu Met Asp Ser Val Ile Gln Ala Leu Ala Glu Leu 1 5 10 15
Glu Gln Lys Val Pro Ala Ala Lys 20 2289PRTHomo sapiens 228Glu Ile
Ile Ile His Gln Asn Tyr Lys 1 5 22919PRTHomo sapiens 229Glu Pro Leu
Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser Leu Phe Ser 1 5 10 15 Val
Thr Lys 23010PRTHomo sapiens 230Met Arg Asp Val Val Leu Phe Glu Lys
Lys 1 5 10 23110PRTHomo sapiens 231Ala Gly Ala Asn Val Leu Ala Lys
Asn Lys 1 5 10 2326PRTHomo sapiens 232Thr Val Ser Ile Pro Arg 1 5
23317PRTHomo sapiens 233Glu Gly Ile Phe Pro Ala Val Phe Val Arg Pro
Cys Pro Ala Glu Ala 1 5 10 15 Lys 23416PRTHomo sapiens 234Leu Ser
Asn Asn Ala Leu Ser Gly Leu Pro Gln Gly Val Phe Gly Lys 1 5 10 15
2359PRTHomo sapiens 235Asp Phe Thr Glu Ala Val Gly Ala Lys 1 5
23615PRTHomo sapiens 236Ser Gln Asp Thr His Gly Ala Val Gly Pro Phe
Leu Phe Arg Lys 1 5 10 15 23728PRTHomo sapiens 237Ile Thr Thr Gly
Gly Asp Val Ile Asn Asn Gly Leu Trp Asn Met Val 1 5 10 15 Ser Val
Glu Glu Leu Glu His Ser Ile Ser Ile Lys 20 25 2388PRTHomo sapiens
238Val Tyr Phe Ala Gly Phe Pro Arg 1 5 23919PRTHomo sapiens 239Asn
Asn Glu Glu Tyr Leu Ala Leu Ile Phe Glu Lys Gly Gly Ser Tyr 1 5 10
15 Leu Gly Arg 24010PRTHomo sapiens 240Gln Arg Gln Glu Glu Leu Cys
Leu Ala Arg 1 5 10 24110PRTHomo sapiens 241Leu Ser Ile Thr Gly Thr
Tyr Asp Leu Lys 1 5 10 2429PRTHomo sapiens 242Leu Ser Ser Trp Val
Leu Leu Met Lys 1 5 24310PRTHomo sapiens 243Ser Val Leu Gly Gln Leu
Gly Ile Thr Lys 1 5 10 24431PRTHomo sapiens 244Ser Val Leu Gly Gln
Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala 1 5 10 15 Asp Leu Ser
Gly Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys 20 25 30
2457PRTHomo sapiens 245Ser Ile Leu Phe Leu Gly Lys 1 5 24612PRTHomo
sapiens 246Glu Val Pro Leu Asn Thr Ile Ile Phe Met Gly Arg 1 5 10
24734PRTHomo sapiens 247Phe Ala Thr Thr Phe Tyr Gln His Leu Ala Asp
Ser Lys Asn Asp Asn 1 5 10 15 Asp Asn Ile Phe Leu Ser Pro Leu Ser
Ile Ser Thr Ala Phe Ala Met 20 25 30 Thr Lys 24812PRTHomo sapiens
248Pro Leu Asp Phe Lys Glu Asn Ala Glu Gln Ser Arg 1 5 10
24929PRTHomo sapiens 249Arg Val Ala Glu Gly Thr Gln Val Leu Glu Leu
Pro Phe Lys Gly Asp 1 5 10 15 Asp Ile Thr Met Val Leu Ile Leu Pro
Lys Pro Glu Lys
20 25 25022PRTHomo sapiens 250Ser Lys Leu Pro Gly Ile Val Ala Glu
Gly Arg Asp Asp Leu Tyr Val 1 5 10 15 Ser Asp Ala Phe His Lys 20
25132PRTHomo sapiens 251Ser Leu Ala Lys Val Glu Lys Glu Leu Thr Pro
Glu Val Leu Gln Glu 1 5 10 15 Trp Leu Asp Glu Leu Glu Glu Met Met
Leu Val Val His Met Pro Arg 20 25 30 25228PRTHomo sapiens 252Val
Ala Glu Gly Thr Gln Val Leu Glu Leu Pro Phe Lys Gly Asp Asp 1 5 10
15 Ile Thr Met Val Leu Ile Leu Pro Lys Pro Glu Lys 20 25
25313PRTHomo sapiens 253Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu
Glu Arg 1 5 10 2548PRTHomo sapiens 254Val Pro Met Met Ser Asp Pro
Lys 1 5 25510PRTHomo sapiens 255Asp Asn Glu Leu Leu Val Tyr Lys Glu
Arg 1 5 10 25610PRTHomo sapiens 256Val Gly Glu Tyr Ser Leu Tyr Ile
Gly Arg 1 5 10 25724PRTHomo sapiens 257Val Val Leu Ser Ser Gly Ser
Gly Pro Gly Leu Asp Leu Pro Leu Val 1 5 10 15 Leu Gly Leu Pro Leu
Gln Leu Lys 20 2589PRTHomo sapiens 258Lys Ala Leu Gln Thr Glu Met
Ala Arg 1 5 2598PRTHomo sapiens 259Asn Asp Leu Leu Ser Ala Thr Lys
1 5 26018PRTHomo sapiens 260Gly Ile Leu Gly Lys Asp Val Ser Gly Phe
Ser Asp Pro Tyr Cys Leu 1 5 10 15 Leu Gly 2618PRTHomo sapiens
261Leu Pro Glu Val Phe Leu Ser Lys 1 5 26211PRTHomo sapiens 262Val
Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 1 5 10 26316PRTHomo sapiens
263Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly Arg
1 5 10 15 26411PRTHomo sapiens 264Pro Gly Gln Val Asp Ala Ala Met
Ala Gly Arg 1 5 10 26511PRTHomo sapiens 265Arg Val Asp Thr Val Asp
Pro Pro Tyr Pro Arg 1 5 10 26613PRTHomo sapiens 266Thr Ser Ala Gly
Thr Arg Gln Pro Gln Phe Ile Ser Arg 1 5 10 267599PRTHomo sapiens
267Met Lys Leu Leu Lys Leu Thr Gly Phe Ile Phe Phe Leu Phe Phe Leu
1 5 10 15 Thr Glu Ser Leu Thr Leu Pro Thr Gln Pro Arg Asp Ile Glu
Asn Phe 20 25 30 Asn Ser Thr Gln Lys Phe Ile Glu Asp Asn Ile Glu
Tyr Ile Thr Ile 35 40 45 Ile Ala Phe Ala Gln Tyr Val Gln Glu Ala
Thr Phe Glu Glu Met Glu 50 55 60 Lys Leu Val Lys Asp Met Val Glu
Tyr Lys Asp Arg Cys Met Ala Asp 65 70 75 80 Lys Thr Leu Pro Glu Cys
Ser Lys Leu Pro Asn Asn Val Leu Gln Glu 85 90 95 Lys Ile Cys Ala
Met Glu Gly Leu Pro Gln Lys His Asn Phe Ser His 100 105 110 Cys Cys
Ser Lys Val Asp Ala Gln Arg Arg Leu Cys Phe Phe Tyr Asn 115 120 125
Lys Lys Ser Asp Val Gly Phe Leu Pro Pro Phe Pro Thr Leu Asp Pro 130
135 140 Glu Glu Lys Cys Gln Ala Tyr Glu Ser Asn Arg Glu Ser Leu Leu
Asn 145 150 155 160 His Phe Leu Tyr Glu Val Ala Arg Arg Asn Pro Phe
Val Phe Ala Pro 165 170 175 Thr Leu Leu Thr Val Ala Val His Phe Glu
Glu Val Ala Lys Ser Cys 180 185 190 Cys Glu Glu Gln Asn Lys Val Asn
Cys Leu Gln Thr Arg Ala Ile Pro 195 200 205 Val Thr Gln Tyr Leu Lys
Ala Phe Ser Ser Tyr Gln Lys His Val Cys 210 215 220 Gly Ala Leu Leu
Lys Phe Gly Thr Lys Val Val His Phe Ile Tyr Ile 225 230 235 240 Ala
Ile Leu Ser Gln Lys Phe Pro Lys Ile Glu Phe Lys Glu Leu Ile 245 250
255 Ser Leu Val Glu Asp Val Ser Ser Asn Tyr Asp Gly Cys Cys Glu Gly
260 265 270 Asp Val Val Gln Cys Ile Arg Asp Thr Ser Lys Val Met Asn
His Ile 275 280 285 Cys Ser Lys Gln Asp Ser Ile Ser Ser Lys Ile Lys
Glu Cys Cys Glu 290 295 300 Lys Lys Ile Pro Glu Arg Gly Gln Cys Ile
Ile Asn Ser Asn Lys Asp 305 310 315 320 Asp Arg Pro Lys Asp Leu Ser
Leu Arg Glu Gly Lys Phe Thr Asp Ser 325 330 335 Glu Asn Val Cys Gln
Glu Arg Asp Ala Asp Pro Asp Thr Phe Phe Ala 340 345 350 Lys Phe Thr
Phe Glu Tyr Ser Arg Arg His Pro Asp Leu Ser Ile Pro 355 360 365 Glu
Leu Leu Arg Ile Val Gln Ile Tyr Lys Asp Leu Leu Arg Asn Cys 370 375
380 Cys Asn Thr Glu Asn Pro Pro Gly Cys Tyr Arg Tyr Ala Glu Asp Lys
385 390 395 400 Phe Asn Glu Thr Thr Glu Lys Ser Leu Lys Met Val Gln
Gln Glu Cys 405 410 415 Lys His Phe Gln Asn Leu Gly Lys Asp Gly Leu
Lys Tyr His Tyr Leu 420 425 430 Ile Arg Leu Thr Lys Ile Ala Pro Gln
Leu Ser Thr Glu Glu Leu Val 435 440 445 Ser Leu Gly Glu Lys Met Val
Thr Ala Phe Thr Thr Cys Cys Thr Leu 450 455 460 Ser Glu Glu Phe Ala
Cys Val Asp Asn Leu Ala Asp Leu Val Phe Gly 465 470 475 480 Glu Leu
Cys Gly Val Asn Glu Asn Arg Thr Ile Asn Pro Ala Val Asp 485 490 495
His Cys Cys Lys Thr Asn Phe Ala Phe Arg Arg Pro Cys Phe Glu Ser 500
505 510 Leu Lys Ala Asp Lys Thr Tyr Val Pro Pro Pro Phe Ser Gln Asp
Leu 515 520 525 Phe Thr Phe His Ala Asp Met Cys Gln Ser Gln Asn Glu
Glu Leu Gln 530 535 540 Arg Lys Thr Asp Arg Phe Leu Val Asn Leu Val
Lys Leu Lys His Glu 545 550 555 560 Leu Thr Asp Glu Glu Leu Gln Ser
Leu Phe Thr Asn Phe Ala Asn Val 565 570 575 Val Asp Lys Cys Cys Lys
Ala Glu Ser Pro Glu Val Cys Phe Asn Glu 580 585 590 Glu Ser Pro Lys
Ile Gly Asn 595 268609PRTHomo sapiens 268Met Lys Trp Val Thr Phe
Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 1 5 10 15 Tyr Ser Arg Gly
Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 20 25 30 His Arg
Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 35 40 45
Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 50
55 60 Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala
Asp 65 70 75 80 Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu
Phe Gly Asp 85 90 95 Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr
Tyr Gly Glu Met Ala 100 105 110 Asp Cys Cys Ala Lys Gln Glu Pro Glu
Arg Asn Glu Cys Phe Leu Gln 115 120 125 His Lys Asp Asp Asn Pro Asn
Leu Pro Arg Leu Val Arg Pro Glu Val 130 135 140 Asp Val Met Cys Thr
Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 145 150 155 160 Lys Tyr
Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 165 170 175
Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 180
185 190 Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp
Glu 195 200 205 Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg
Leu Lys Cys 210 215 220 Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe
Lys Ala Trp Ala Val 225 230 235 240 Ala Arg Leu Ser Gln Arg Phe Pro
Lys Ala Glu Phe Ala Glu Val Ser 245 250 255 Lys Leu Val Thr Asp Leu
Thr Lys Val His Thr Glu Cys Cys His Gly 260 265 270 Asp Leu Leu Glu
Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 275 280 285 Cys Glu
Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 290 295 300
Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 305
310 315 320 Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val
Glu Ser 325 330 335 Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp
Val Phe Leu Gly 340 345 350 Met Phe Leu Tyr Glu Tyr Ala Arg Arg His
Pro Asp Tyr Ser Val Val 355 360 365 Leu Leu Leu Arg Leu Ala Lys Thr
Tyr Glu Thr Thr Leu Glu Lys Cys 370 375 380 Cys Ala Ala Ala Asp Pro
His Glu Cys Tyr Ala Lys Val Phe Asp Glu 385 390 395 400 Phe Lys Pro
Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 405 410 415 Glu
Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 420 425
430 Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val
435 440 445 Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys
Lys His 450 455 460 Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr
Leu Ser Val Val 465 470 475 480 Leu Asn Gln Leu Cys Val Leu His Glu
Lys Thr Pro Val Ser Asp Arg 485 490 495 Val Thr Lys Cys Cys Thr Glu
Ser Leu Val Asn Arg Arg Pro Cys Phe 500 505 510 Ser Ala Leu Glu Val
Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 515 520 525 Glu Thr Phe
Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 530 535 540 Arg
Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 545 550
555 560 Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe
Ala 565 570 575 Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu
Thr Cys Phe 580 585 590 Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser
Gln Ala Ala Leu Gly 595 600 605 Leu 269495PRTHomo sapiens 269Met
Ser Met Leu Val Val Phe Leu Leu Leu Trp Gly Val Thr Trp Gly 1 5 10
15 Pro Val Thr Glu Ala Ala Ile Phe Tyr Glu Thr Gln Pro Ser Leu Trp
20 25 30 Ala Glu Ser Glu Ser Leu Leu Lys Pro Leu Ala Asn Val Thr
Leu Thr 35 40 45 Cys Gln Ala His Leu Glu Thr Pro Asp Phe Gln Leu
Phe Lys Asn Gly 50 55 60 Val Ala Gln Glu Pro Val His Leu Asp Ser
Pro Ala Ile Lys His Gln 65 70 75 80 Phe Leu Leu Thr Gly Asp Thr Gln
Gly Arg Tyr Arg Cys Arg Ser Gly 85 90 95 Leu Ser Thr Gly Trp Thr
Gln Leu Ser Lys Leu Leu Glu Leu Thr Gly 100 105 110 Pro Lys Ser Leu
Pro Ala Pro Trp Leu Ser Met Ala Pro Val Ser Trp 115 120 125 Ile Thr
Pro Gly Leu Lys Thr Thr Ala Val Cys Arg Gly Val Leu Arg 130 135 140
Gly Val Thr Phe Leu Leu Arg Arg Glu Gly Asp His Glu Phe Leu Glu 145
150 155 160 Val Pro Glu Ala Gln Glu Asp Val Glu Ala Thr Phe Pro Val
His Gln 165 170 175 Pro Gly Asn Tyr Ser Cys Ser Tyr Arg Thr Asp Gly
Glu Gly Ala Leu 180 185 190 Ser Glu Pro Ser Ala Thr Val Thr Ile Glu
Glu Leu Ala Ala Pro Pro 195 200 205 Pro Pro Val Leu Met His His Gly
Glu Ser Ser Gln Val Leu His Pro 210 215 220 Gly Asn Lys Val Thr Leu
Thr Cys Val Ala Pro Leu Ser Gly Val Asp 225 230 235 240 Phe Gln Leu
Arg Arg Gly Glu Lys Glu Leu Leu Val Pro Arg Ser Ser 245 250 255 Thr
Ser Pro Asp Arg Ile Phe Phe His Leu Asn Ala Val Ala Leu Gly 260 265
270 Asp Gly Gly His Tyr Thr Cys Arg Tyr Arg Leu His Asp Asn Gln Asn
275 280 285 Gly Trp Ser Gly Asp Ser Ala Pro Val Glu Leu Ile Leu Ser
Asp Glu 290 295 300 Thr Leu Pro Ala Pro Glu Phe Ser Pro Glu Pro Glu
Ser Gly Arg Ala 305 310 315 320 Leu Arg Leu Arg Cys Leu Ala Pro Leu
Glu Gly Ala Arg Phe Ala Leu 325 330 335 Val Arg Glu Asp Arg Gly Gly
Arg Arg Val His Arg Phe Gln Ser Pro 340 345 350 Ala Gly Thr Glu Ala
Leu Phe Glu Leu His Asn Ile Ser Val Ala Asp 355 360 365 Ser Ala Asn
Tyr Ser Cys Val Tyr Val Asp Leu Lys Pro Pro Phe Gly 370 375 380 Gly
Ser Ala Pro Ser Glu Arg Leu Glu Leu His Val Asp Gly Pro Pro 385 390
395 400 Pro Arg Pro Gln Leu Arg Ala Thr Trp Ser Gly Ala Val Leu Ala
Gly 405 410 415 Arg Asp Ala Val Leu Arg Cys Glu Gly Pro Ile Pro Asp
Val Thr Phe 420 425 430 Glu Leu Leu Arg Glu Gly Glu Thr Lys Ala Val
Lys Thr Val Arg Thr 435 440 445 Pro Gly Ala Ala Ala Asn Leu Glu Leu
Ile Phe Val Gly Pro Gln His 450 455 460 Ala Gly Asn Tyr Arg Cys Arg
Tyr Arg Ser Trp Val Pro His Thr Phe 465 470 475 480 Glu Ser Glu Leu
Ser Asp Pro Val Glu Leu Leu Val Ala Glu Ser 485 490 495
270433PRTHomo sapiens 270Met Glu Arg Met Leu Pro Leu Leu Ala Leu
Gly Leu Leu Ala Ala Gly 1 5 10 15 Phe Cys Pro Ala Val Leu Cys His
Pro Asn Ser Pro Leu Asp Glu Glu 20 25 30 Asn Leu Thr Gln Glu Asn
Gln Asp Arg Gly Thr His Val Asp Leu Gly 35 40 45 Leu Ala Ser Ala
Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu 50 55 60 Val Leu
Lys Ala Leu Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile 65 70 75 80
Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu 85
90 95 Thr Glu Ile Leu Lys Ala Ser Ser Ser Pro His Gly Asp Leu Leu
Arg 100 105 110 Gln Lys Phe Thr Gln Ser Phe Gln His Leu Arg Ala Pro
Ser Ile Ser 115 120 125 Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn
Ala Met Phe Val Lys 130 135 140 Glu Gln Leu Ser Leu Leu Asp Arg Phe
Thr Glu Asp Ala Lys Arg Leu 145 150 155 160 Tyr Gly Ser Glu Ala Phe
Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala 165 170 175 Lys Lys Leu Ile
Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile 180 185 190 Thr Asp
Leu Ile Lys Asp Pro Asp Ser Gln Thr Met Met Val Leu Val 195 200 205
Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro Gln 210
215 220 Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val
Met 225 230 235 240 Val Pro Met Met Ser Leu His His Leu Thr Ile Pro
Tyr Phe Arg Asp 245 250 255 Glu Glu Leu Ser Cys Thr Val Val Glu Leu
Lys Tyr Thr Gly Asn Ala 260 265 270 Ser Ala Leu Phe Ile Leu Pro Asp
Gln Asp Lys Met Glu Glu Val Glu
275 280 285 Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser
Leu Glu 290 295 300 Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe
Ser Ile Ser Arg 305 310 315 320 Asp Tyr Asn Leu Asn Asp Ile Leu Leu
Gln Leu Gly Ile Glu Glu Ala 325 330 335 Phe Thr Ser Lys Ala Asp Leu
Ser Gly Ile Thr Gly Ala Arg Asn Leu 340 345 350 Ala Val Ser Gln Val
Val His Lys Val Val Ser Asp Val Phe Glu Glu 355 360 365 Gly Thr Glu
Ala Ser Ala Ala Thr Ala Val Lys Ile Thr Leu Leu Ser 370 375 380 Ala
Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe Leu 385 390
395 400 Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser
Lys 405 410 415 Val Thr Asn Pro Ser Lys Pro Arg Ala Cys Ile Lys Gln
Trp Gly Ser 420 425 430 Gln 2711474PRTHomo sapiens 271Met Gly Lys
Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 1 5 10 15 Val
Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 20 25
30 Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys
35 40 45 Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala
Ser Leu 50 55 60 Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp
Leu Glu Ala Glu 65 70 75 80 Asn Asp Val Leu His Cys Val Ala Phe Ala
Val Pro Lys Ser Ser Ser 85 90 95 Asn Glu Glu Val Met Phe Leu Thr
Val Gln Val Lys Gly Pro Thr Gln 100 105 110 Glu Phe Lys Lys Arg Thr
Thr Val Met Val Lys Asn Glu Asp Ser Leu 115 120 125 Val Phe Val Gln
Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 130 135 140 Lys Phe
Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 145 150 155
160 Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala
165 170 175 Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe
Ser Phe 180 185 190 Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys
Val Val Val Gln 195 200 205 Lys Lys Ser Gly Gly Arg Thr Glu His Pro
Phe Thr Val Glu Glu Phe 210 215 220 Val Leu Pro Lys Phe Glu Val Gln
Val Thr Val Pro Lys Ile Ile Thr 225 230 235 240 Ile Leu Glu Glu Glu
Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr 245 250 255 Gly Lys Pro
Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr 260 265 270 Ser
Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 275 280
285 Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val
290 295 300 Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met
Lys Leu 305 310 315 320 His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr
Val Val Glu Leu Thr 325 330 335 Gly Arg Gln Ser Ser Glu Ile Thr Arg
Thr Ile Thr Lys Leu Ser Phe 340 345 350 Val Lys Val Asp Ser His Phe
Arg Gln Gly Ile Pro Phe Phe Gly Gln 355 360 365 Val Arg Leu Val Asp
Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 370 375 380 Phe Ile Arg
Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp 385 390 395 400
Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly 405
410 415 Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys
Tyr 420 425 430 Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His
His Thr Ala 435 440 445 Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val
His Leu Glu Pro Met 450 455 460 Ser His Glu Leu Pro Cys Gly His Thr
Gln Thr Val Gln Ala His Tyr 465 470 475 480 Ile Leu Asn Gly Gly Thr
Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 485 490 495 Tyr Leu Ile Met
Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly 500 505 510 Leu Leu
Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 515 520 525
Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 530
535 540 Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp
Val 545 550 555 560 Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe
Ser Pro Ser Gln 565 570 575 Ser Leu Pro Ala Ser His Ala His Leu Arg
Val Thr Ala Ala Pro Gln 580 585 590 Ser Val Cys Ala Leu Arg Ala Val
Asp Gln Ser Val Leu Leu Met Lys 595 600 605 Pro Asp Ala Glu Leu Ser
Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 610 615 620 Lys Asp Leu Thr
Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asp Glu 625 630 635 640 Asp
Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr 645 650
655 Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp
660 665 670 Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro
Lys Met 675 680 685 Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro
Glu Gly Leu Arg 690 695 700 Val Gly Phe Tyr Glu Ser Asp Val Met Gly
Arg Gly His Ala Arg Leu 705 710 715 720 Val His Val Glu Glu Pro His
Thr Glu Thr Val Arg Lys Tyr Phe Pro 725 730 735 Glu Thr Trp Ile Trp
Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 740 745 750 Glu Val Gly
Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly 755 760 765 Ala
Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala 770 775
780 Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr
785 790 795 800 Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr
Val Leu Asn 805 810 815 Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln
Leu Glu Ala Ser Pro 820 825 830 Ala Phe Leu Ala Val Pro Val Glu Lys
Glu Gln Ala Pro His Cys Ile 835 840 845 Cys Ala Asn Gly Arg Gln Thr
Val Ser Trp Ala Val Thr Pro Lys Ser 850 855 860 Leu Gly Asn Val Asn
Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln 865 870 875 880 Glu Leu
Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 885 890 895
Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 900
905 910 Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val
Ser 915 920 925 Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu
Glu Ser Ala 930 935 940 Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu
Gly Ser Ala Met Gln 945 950 955 960 Asn Thr Gln Asn Leu Leu Gln Met
Pro Tyr Gly Cys Gly Glu Gln Asn 965 970 975 Met Val Leu Phe Ala Pro
Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 980 985 990 Thr Gln Gln Leu
Thr Pro Glu Val Lys Ser Lys Ala Ile Gly Tyr Leu 995 1000 1005 Asn
Thr Gly Tyr Gln Arg Gln Leu Asn Tyr Lys His Tyr Asp Gly 1010 1015
1020 Ser Tyr Ser Thr Phe Gly Glu Arg Tyr Gly Arg Asn Gln Gly Asn
1025 1030 1035 Thr Trp Leu Thr Ala Phe Val Leu Lys Thr Phe Ala Gln
Ala Arg 1040 1045 1050 Ala Tyr Ile Phe Ile Asp Glu Ala His Ile Thr
Gln Ala Leu Ile 1055 1060 1065 Trp Leu Ser Gln Arg Gln Lys Asp Asn
Gly Cys Phe Arg Ser Ser 1070 1075 1080 Gly Ser Leu Leu Asn Asn Ala
Ile Lys Gly Gly Val Glu Asp Glu 1085 1090 1095 Val Thr Leu Ser Ala
Tyr Ile Thr Ile Ala Leu Leu Glu Ile Pro 1100 1105 1110 Leu Thr Val
Thr His Pro Val Val Arg Asn Ala Leu Phe Cys Leu 1115 1120 1125 Glu
Ser Ala Trp Lys Thr Ala Gln Glu Gly Asp His Gly Ser His 1130 1135
1140 Val Tyr Thr Lys Ala Leu Leu Ala Tyr Ala Phe Ala Leu Ala Gly
1145 1150 1155 Asn Gln Asp Lys Arg Lys Glu Val Leu Lys Ser Leu Asn
Glu Glu 1160 1165 1170 Ala Val Lys Lys Asp Asn Ser Val His Trp Glu
Arg Pro Gln Lys 1175 1180 1185 Pro Lys Ala Pro Val Gly His Phe Tyr
Glu Pro Gln Ala Pro Ser 1190 1195 1200 Ala Glu Val Glu Met Thr Ser
Tyr Val Leu Leu Ala Tyr Leu Thr 1205 1210 1215 Ala Gln Pro Ala Pro
Thr Ser Glu Asp Leu Thr Ser Ala Thr Asn 1220 1225 1230 Ile Val Lys
Trp Ile Thr Lys Gln Gln Asn Ala Gln Gly Gly Phe 1235 1240 1245 Ser
Ser Thr Gln Asp Thr Val Val Ala Leu His Ala Leu Ser Lys 1250 1255
1260 Tyr Gly Ala Ala Thr Phe Thr Arg Thr Gly Lys Ala Ala Gln Val
1265 1270 1275 Thr Ile Gln Ser Ser Gly Thr Phe Ser Ser Lys Phe Gln
Val Asp 1280 1285 1290 Asn Asn Asn Arg Leu Leu Leu Gln Gln Val Ser
Leu Pro Glu Leu 1295 1300 1305 Pro Gly Glu Tyr Ser Met Lys Val Thr
Gly Glu Gly Cys Val Tyr 1310 1315 1320 Leu Gln Thr Ser Leu Lys Tyr
Asn Ile Leu Pro Glu Lys Glu Glu 1325 1330 1335 Phe Pro Phe Ala Leu
Gly Val Gln Thr Leu Pro Gln Thr Cys Asp 1340 1345 1350 Glu Pro Lys
Ala His Thr Ser Phe Gln Ile Ser Leu Ser Val Ser 1355 1360 1365 Tyr
Thr Gly Ser Arg Ser Ala Ser Asn Met Ala Ile Val Asp Val 1370 1375
1380 Lys Met Val Ser Gly Phe Ile Pro Leu Lys Pro Thr Val Lys Met
1385 1390 1395 Leu Glu Arg Ser Asn His Val Ser Arg Thr Glu Val Ser
Ser Asn 1400 1405 1410 His Val Leu Ile Tyr Leu Asp Lys Val Ser Asn
Gln Thr Leu Ser 1415 1420 1425 Leu Phe Phe Thr Val Leu Gln Asp Val
Pro Val Arg Asp Leu Lys 1430 1435 1440 Pro Ala Ile Val Lys Val Tyr
Asp Tyr Tyr Glu Thr Asp Glu Phe 1445 1450 1455 Ala Ile Ala Glu Tyr
Asn Ala Pro Cys Ser Lys Asp Leu Gly Asn 1460 1465 1470 Ala
272491PRTHomo sapiens 272Met Ala Leu Leu Trp Gly Leu Leu Val Leu
Ser Trp Ser Cys Leu Gln 1 5 10 15 Gly Pro Cys Ser Val Phe Ser Pro
Val Ser Ala Met Glu Pro Leu Gly 20 25 30 Trp Gln Leu Thr Ser Gly
Pro Asn Gln Glu Gln Val Ser Pro Leu Thr 35 40 45 Leu Leu Lys Leu
Gly Asn Gln Glu Pro Gly Gly Gln Thr Ala Leu Lys 50 55 60 Ser Pro
Pro Gly Val Cys Ser Arg Asp Pro Thr Pro Glu Gln Thr His 65 70 75 80
Arg Leu Ala Arg Ala Met Met Ala Phe Thr Ala Asp Leu Phe Ser Leu 85
90 95 Val Ala Gln Thr Ser Thr Cys Pro Asn Leu Ile Leu Ser Pro Leu
Ser 100 105 110 Val Ala Leu Ala Leu Ser His Leu Ala Leu Gly Ala Gln
Asn His Thr 115 120 125 Leu Gln Arg Leu Gln Gln Val Leu His Ala Gly
Ser Gly Pro Cys Leu 130 135 140 Pro His Leu Leu Ser Arg Leu Cys Gln
Asp Leu Gly Pro Gly Ala Phe 145 150 155 160 Arg Leu Ala Ala Arg Met
Tyr Leu Gln Lys Gly Phe Pro Ile Lys Glu 165 170 175 Asp Phe Leu Glu
Gln Ser Glu Gln Leu Phe Gly Ala Lys Pro Val Ser 180 185 190 Leu Thr
Gly Lys Gln Glu Asp Asp Leu Ala Asn Ile Asn Gln Trp Val 195 200 205
Lys Glu Ala Thr Glu Gly Lys Ile Gln Glu Phe Leu Ser Gly Leu Pro 210
215 220 Glu Asp Thr Val Leu Leu Leu Leu Asn Ala Ile His Phe Gln Gly
Phe 225 230 235 240 Trp Arg Asn Lys Phe Asp Pro Ser Leu Thr Gln Arg
Asp Ser Phe His 245 250 255 Leu Asp Glu Gln Phe Thr Val Pro Val Glu
Met Met Gln Ala Arg Thr 260 265 270 Tyr Pro Leu Arg Trp Phe Leu Leu
Glu Gln Pro Glu Ile Gln Val Ala 275 280 285 His Phe Pro Phe Lys Asn
Asn Met Ser Phe Val Val Leu Val Pro Thr 290 295 300 His Phe Glu Trp
Asn Val Ser Gln Val Leu Ala Asn Leu Ser Trp Asp 305 310 315 320 Thr
Leu His Pro Pro Leu Val Trp Glu Arg Pro Thr Lys Val Arg Leu 325 330
335 Pro Lys Leu Tyr Leu Lys His Gln Met Asp Leu Val Ala Thr Leu Ser
340 345 350 Gln Leu Gly Leu Gln Glu Leu Phe Gln Ala Pro Asp Leu Arg
Gly Ile 355 360 365 Ser Glu Gln Ser Leu Val Val Ser Gly Val Gln His
Gln Ser Thr Leu 370 375 380 Glu Leu Ser Glu Val Gly Val Glu Ala Ala
Ala Ala Thr Ser Ile Ala 385 390 395 400 Met Ser Arg Met Ser Leu Ser
Ser Phe Ser Val Asn Arg Pro Phe Leu 405 410 415 Phe Phe Ile Phe Glu
Asp Thr Thr Gly Leu Pro Leu Phe Val Gly Ser 420 425 430 Val Arg Asn
Pro Asn Pro Ser Ala Pro Arg Glu Leu Lys Glu Gln Gln 435 440 445 Asp
Ser Pro Gly Asn Lys Asp Phe Leu Gln Ser Leu Lys Gly Phe Pro 450 455
460 Arg Gly Asp Lys Leu Phe Gly Pro Asp Leu Lys Leu Val Pro Pro Met
465 470 475 480 Glu Glu Asp Tyr Pro Gln Phe Gly Ser Pro Lys 485 490
273485PRTHomo sapiens 273Met Arg Lys Arg Ala Pro Gln Ser Glu Met
Ala Pro Ala Gly Val Ser 1 5 10 15 Leu Arg Ala Thr Ile Leu Cys Leu
Leu Ala Trp Ala Gly Leu Ala Ala 20 25 30 Gly Asp Arg Val Tyr Ile
His Pro Phe His Leu Val Ile His Asn Glu 35 40 45 Ser Thr Cys Glu
Gln Leu Ala Lys Ala Asn Ala Gly Lys Pro Lys Asp 50 55 60 Pro Thr
Phe Ile Pro Ala Pro Ile Gln Ala Lys Thr Ser Pro Val Asp 65 70 75 80
Glu Lys Ala Leu Gln Asp Gln Leu Val Leu Val Ala Ala Lys Leu Asp 85
90 95 Thr Glu Asp Lys Leu Arg Ala Ala Met Val Gly Met Leu Ala Asn
Phe 100 105 110 Leu Gly Phe Arg Ile Tyr Gly Met His Ser Glu Leu Trp
Gly Val Val 115 120 125 His Gly Ala Thr Val Leu Ser Pro Thr Ala Val
Phe Gly Thr Leu Ala 130 135 140 Ser Leu Tyr Leu Gly Ala Leu Asp His
Thr Ala Asp Arg Leu Gln Ala 145 150
155 160 Ile Leu Gly Val Pro Trp Lys Asp Lys Asn Cys Thr Ser Arg Leu
Asp 165 170 175 Ala His Lys Val Leu Ser Ala Leu Gln Ala Val Gln Gly
Leu Leu Val 180 185 190 Ala Gln Gly Arg Ala Asp Ser Gln Ala Gln Leu
Leu Leu Ser Thr Val 195 200 205 Val Gly Val Phe Thr Ala Pro Gly Leu
His Leu Lys Gln Pro Phe Val 210 215 220 Gln Gly Leu Ala Leu Tyr Thr
Pro Val Val Leu Pro Arg Ser Leu Asp 225 230 235 240 Phe Thr Glu Leu
Asp Val Ala Ala Glu Lys Ile Asp Arg Phe Met Gln 245 250 255 Ala Val
Thr Gly Trp Lys Thr Gly Cys Ser Leu Met Gly Ala Ser Val 260 265 270
Asp Ser Thr Leu Ala Phe Asn Thr Tyr Val His Phe Gln Gly Lys Met 275
280 285 Lys Gly Phe Ser Leu Leu Ala Glu Pro Gln Glu Phe Trp Val Asp
Asn 290 295 300 Ser Thr Ser Val Ser Val Pro Met Leu Ser Gly Met Gly
Thr Phe Gln 305 310 315 320 His Trp Ser Asp Ile Gln Asp Asn Phe Ser
Val Thr Gln Val Pro Phe 325 330 335 Thr Glu Ser Ala Cys Leu Leu Leu
Ile Gln Pro His Tyr Ala Ser Asp 340 345 350 Leu Asp Lys Val Glu Gly
Leu Thr Phe Gln Gln Asn Ser Leu Asn Trp 355 360 365 Met Lys Lys Leu
Ser Pro Arg Thr Ile His Leu Thr Met Pro Gln Leu 370 375 380 Val Leu
Gln Gly Ser Tyr Asp Leu Gln Asp Leu Leu Ala Gln Ala Glu 385 390 395
400 Leu Pro Ala Ile Leu His Thr Glu Leu Asn Leu Gln Lys Leu Ser Asn
405 410 415 Asp Arg Ile Arg Val Gly Glu Val Leu Asn Ser Ile Phe Phe
Glu Leu 420 425 430 Glu Ala Asp Glu Arg Glu Pro Thr Glu Ser Thr Gln
Gln Leu Asn Lys 435 440 445 Pro Glu Val Leu Glu Val Thr Leu Asn Arg
Pro Phe Leu Phe Ala Val 450 455 460 Tyr Asp Gln Ser Ala Thr Ala Leu
His Phe Leu Gly Arg Val Ala Asn 465 470 475 480 Pro Leu Ser Thr Ala
485 274267PRTHomo sapiens 274Met Lys Ala Ala Val Leu Thr Leu Ala
Val Leu Phe Leu Thr Gly Ser 1 5 10 15 Gln Ala Arg His Phe Trp Gln
Gln Asp Glu Pro Pro Gln Ser Pro Trp 20 25 30 Asp Arg Val Lys Asp
Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 35 40 45 Ser Gly Arg
Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 50 55 60 Gln
Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 65 70
75 80 Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe
Trp 85 90 95 Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu
Met Ser Lys 100 105 110 Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro
Tyr Leu Asp Asp Phe 115 120 125 Gln Lys Lys Trp Gln Glu Glu Met Glu
Leu Tyr Arg Gln Lys Val Glu 130 135 140 Pro Leu Arg Ala Glu Leu Gln
Glu Gly Ala Arg Gln Lys Leu His Glu 145 150 155 160 Leu Gln Glu Lys
Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 165 170 175 Arg Ala
His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 180 185 190
Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 195
200 205 Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His
Leu 210 215 220 Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp
Leu Arg Gln 225 230 235 240 Gly Leu Leu Pro Val Leu Glu Ser Phe Lys
Val Ser Phe Leu Ser Ala 245 250 255 Leu Glu Glu Tyr Thr Lys Lys Leu
Asn Thr Gln 260 265 275100PRTHomo sapiens 275Met Lys Leu Leu Ala
Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 1 5 10 15 Glu Gly Ala
Leu Val Arg Arg Gln Ala Lys Glu Pro Cys Val Glu Ser 20 25 30 Leu
Val Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu 35 40
45 Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr
50 55 60 Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys
Ala Gly 65 70 75 80 Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu
Leu Gly Thr Gln 85 90 95 Pro Ala Thr Gln 100 276396PRTHomo sapiens
276Met Phe Leu Lys Ala Val Val Leu Thr Leu Ala Leu Val Ala Val Ala
1 5 10 15 Gly Ala Arg Ala Glu Val Ser Ala Asp Gln Val Ala Thr Val
Met Trp 20 25 30 Asp Tyr Phe Ser Gln Leu Ser Asn Asn Ala Lys Glu
Ala Val Glu His 35 40 45 Leu Gln Lys Ser Glu Leu Thr Gln Gln Leu
Asn Ala Leu Phe Gln Asp 50 55 60 Lys Leu Gly Glu Val Asn Thr Tyr
Ala Gly Asp Leu Gln Lys Lys Leu 65 70 75 80 Val Pro Phe Ala Thr Glu
Leu His Glu Arg Leu Ala Lys Asp Ser Glu 85 90 95 Lys Leu Lys Glu
Glu Ile Gly Lys Glu Leu Glu Glu Leu Arg Ala Arg 100 105 110 Leu Leu
Pro His Ala Asn Glu Val Ser Gln Lys Ile Gly Asp Asn Leu 115 120 125
Arg Glu Leu Gln Gln Arg Leu Glu Pro Tyr Ala Asp Gln Leu Arg Thr 130
135 140 Gln Val Asn Thr Gln Ala Glu Gln Leu Arg Arg Gln Leu Thr Pro
Tyr 145 150 155 160 Ala Gln Arg Met Glu Arg Val Leu Arg Glu Asn Ala
Asp Ser Leu Gln 165 170 175 Ala Ser Leu Arg Pro His Ala Asp Glu Leu
Lys Ala Lys Ile Asp Gln 180 185 190 Asn Val Glu Glu Leu Lys Gly Arg
Leu Thr Pro Tyr Ala Asp Glu Phe 195 200 205 Lys Val Lys Ile Asp Gln
Thr Val Glu Glu Leu Arg Arg Ser Leu Ala 210 215 220 Pro Tyr Ala Gln
Asp Thr Gln Glu Lys Leu Asn His Gln Leu Glu Gly 225 230 235 240 Leu
Thr Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Lys Ala Arg Ile 245 250
255 Ser Ala Ser Ala Glu Glu Leu Arg Gln Arg Leu Ala Pro Leu Ala Glu
260 265 270 Asp Val Arg Gly Asn Leu Arg Gly Asn Thr Glu Gly Leu Gln
Lys Ser 275 280 285 Leu Ala Glu Leu Gly Gly His Leu Asp Gln Gln Val
Glu Glu Phe Arg 290 295 300 Arg Arg Val Glu Pro Tyr Gly Glu Asn Phe
Asn Lys Ala Leu Val Gln 305 310 315 320 Gln Met Glu Gln Leu Arg Thr
Lys Leu Gly Pro His Ala Gly Asp Val 325 330 335 Glu Gly His Leu Ser
Phe Leu Glu Lys Asp Leu Arg Asp Lys Val Asn 340 345 350 Ser Phe Phe
Ser Thr Phe Lys Glu Lys Glu Ser Gln Asp Lys Thr Leu 355 360 365 Ser
Leu Pro Glu Leu Glu Gln Gln Gln Glu Gln His Gln Glu Gln Gln 370 375
380 Gln Glu Gln Val Gln Met Leu Ala Pro Leu Glu Ser 385 390 395
2774563PRTHomo sapiens 277Met Asp Pro Pro Arg Pro Ala Leu Leu Ala
Leu Leu Ala Leu Pro Ala 1 5 10 15 Leu Leu Leu Leu Leu Leu Ala Gly
Ala Arg Ala Glu Glu Glu Met Leu 20 25 30 Glu Asn Val Ser Leu Val
Cys Pro Lys Asp Ala Thr Arg Phe Lys His 35 40 45 Leu Arg Lys Tyr
Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val 50 55 60 Pro Gly
Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val 65 70 75 80
Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln 85
90 95 Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala
Leu 100 105 110 Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala
Met Ser Arg 115 120 125 Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys
Gln Val Phe Leu Tyr 130 135 140 Pro Glu Lys Asp Glu Pro Thr Tyr Ile
Leu Asn Ile Lys Arg Gly Ile 145 150 155 160 Ile Ser Ala Leu Leu Val
Pro Pro Glu Thr Glu Glu Ala Lys Gln Val 165 170 175 Leu Phe Leu Asp
Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val 180 185 190 Lys Thr
Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp 195 200 205
Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro 210
215 220 Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile
Ser 225 230 235 240 Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys
Arg Lys His Val 245 250 255 Ala Glu Ala Ile Cys Lys Glu Gln His Leu
Phe Leu Pro Phe Ser Tyr 260 265 270 Asn Asn Lys Tyr Gly Met Val Ala
Gln Val Thr Gln Thr Leu Lys Leu 275 280 285 Glu Asp Thr Pro Lys Ile
Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys 290 295 300 Lys Met Gly Leu
Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys 305 310 315 320 Gln
Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr 325 330
335 Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val
340 345 350 Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu
Leu Pro 355 360 365 Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln
Ala Leu Val Gln 370 375 380 Cys Gly Gln Pro Gln Cys Ser Thr His Ile
Leu Gln Trp Leu Lys Arg 385 390 395 400 Val His Ala Asn Pro Leu Leu
Ile Asp Val Val Thr Tyr Leu Val Ala 405 410 415 Leu Ile Pro Glu Pro
Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met 420 425 430 Ala Arg Asp
Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala 435 440 445 Val
Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu 450 455
460 Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly
465 470 475 480 Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly
Asn Met Gly 485 490 495 Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys
Ser Ser Ile Leu Lys 500 505 510 Cys Val Gln Ser Thr Lys Pro Ser Leu
Met Ile Gln Lys Ala Ala Ile 515 520 525 Gln Ala Leu Arg Lys Met Glu
Pro Lys Asp Lys Asp Gln Glu Val Leu 530 535 540 Leu Gln Thr Phe Leu
Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala 545 550 555 560 Ala Tyr
Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys 565 570 575
Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe 580
585 590 Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp
Ile 595 600 605 Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu
Ser Gln Leu 610 615 620 Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg
Asn Tyr Gln Leu Tyr 625 630 635 640 Lys Ser Val Ser Leu Pro Ser Leu
Asp Pro Ala Ser Ala Lys Ile Glu 645 650 655 Gly Asn Leu Ile Phe Asp
Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met 660 665 670 Leu Lys Thr Thr
Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile 675 680 685 Glu Ile
Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu 690 695 700
Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr 705
710 715 720 Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu
Val Asp 725 730 735 His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln
Asp Met Val Asn 740 745 750 Gly Ile Met Leu Ser Val Glu Lys Leu Ile
Lys Asp Leu Lys Ser Lys 755 760 765 Glu Val Pro Glu Ala Arg Ala Tyr
Leu Arg Ile Leu Gly Glu Glu Leu 770 775 780 Gly Phe Ala Ser Leu His
Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu 785 790 795 800 Met Gly Ala
Arg Thr Leu Gln Gly Ile Pro Gln Met Ile Gly Glu Val 805 810 815 Ile
Arg Lys Gly Ser Lys Asn Asp Phe Phe Leu His Tyr Ile Phe Met 820 825
830 Glu Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile
835 840 845 Ser Ser Ser Gly Val Ile Ala Pro Gly Ala Lys Ala Gly Val
Lys Leu 850 855 860 Glu Val Ala Asn Met Gln Ala Glu Leu Val Ala Lys
Pro Ser Val Ser 865 870 875 880 Val Glu Phe Val Thr Asn Met Gly Ile
Ile Ile Pro Asp Phe Ala Arg 885 890 895 Ser Gly Val Gln Met Asn Thr
Asn Phe Phe His Glu Ser Gly Leu Glu 900 905 910 Ala His Val Ala Leu
Lys Ala Gly Lys Leu Lys Phe Ile Ile Pro Ser 915 920 925 Pro Lys Arg
Pro Val Lys Leu Leu Ser Gly Gly Asn Thr Leu His Leu 930 935 940 Val
Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg 945 950
955 960 Gln Ser Trp Ser Val Cys Lys Gln Val Phe Pro Gly Leu Asn Tyr
Cys 965 970 975 Thr Ser Gly Ala Tyr Ser Asn Ala Ser Ser Thr Asp Ser
Ala Ser Tyr 980 985 990 Tyr Pro Leu Thr Gly Asp Thr Arg Leu Glu Leu
Glu Leu Arg Pro Thr 995 1000 1005 Gly Glu Ile Glu Gln Tyr Ser Val
Ser Ala Thr Tyr Glu Leu Gln 1010 1015 1020 Arg Glu Asp Arg Ala Leu
Val Asp Thr Leu Lys Phe Val Thr Gln 1025 1030 1035 Ala Glu Gly Ala
Lys Gln Thr Glu Ala Thr Met Thr Phe Lys Tyr 1040 1045 1050 Asn Arg
Gln Ser Met Thr Leu Ser Ser Glu Val Gln Ile Pro Asp 1055 1060 1065
Phe Asp Val Asp Leu Gly Thr Ile Leu Arg Val Asn Asp Glu Ser 1070
1075 1080 Thr Glu Gly Lys Thr Ser Tyr Arg Leu Thr Leu Asp Ile Gln
Asn 1085 1090 1095 Lys Lys Ile Thr Glu Val Ala Leu Met Gly His Leu
Ser Cys Asp 1100 1105 1110 Thr Lys Glu Glu Arg Lys Ile Lys Gly Val
Ile Ser Ile Pro Arg 1115 1120 1125 Leu Gln Ala Glu Ala Arg Ser Glu
Ile Leu Ala His Trp Ser Pro 1130 1135 1140 Ala Lys Leu Leu Leu Gln
Met Asp Ser Ser Ala Thr Ala Tyr Gly 1145 1150 1155 Ser Thr Val Ser
Lys Arg Val Ala Trp His Tyr Asp Glu Glu Lys 1160 1165 1170 Ile Glu
Phe Glu Trp Asn Thr Gly Thr Asn Val Asp Thr Lys Lys 1175 1180 1185
Met Thr Ser Asn Phe Pro Val
Asp Leu Ser Asp Tyr Pro Lys Ser 1190 1195 1200 Leu His Met Tyr Ala
Asn Arg Leu Leu Asp His Arg Val Pro Glu 1205 1210 1215 Thr Asp Met
Thr Phe Arg His Val Gly Ser Lys Leu Ile Val Ala 1220 1225 1230 Met
Ser Ser Trp Leu Gln Lys Ala Ser Gly Ser Leu Pro Tyr Thr 1235 1240
1245 Gln Thr Leu Gln Asp His Leu Asn Ser Leu Lys Glu Phe Asn Leu
1250 1255 1260 Gln Asn Met Gly Leu Pro Asp Phe His Ile Pro Glu Asn
Leu Phe 1265 1270 1275 Leu Lys Ser Asp Gly Arg Val Lys Tyr Thr Leu
Asn Lys Asn Ser 1280 1285 1290 Leu Lys Ile Glu Ile Pro Leu Pro Phe
Gly Gly Lys Ser Ser Arg 1295 1300 1305 Asp Leu Lys Met Leu Glu Thr
Val Arg Thr Pro Ala Leu His Phe 1310 1315 1320 Lys Ser Val Gly Phe
His Leu Pro Ser Arg Glu Phe Gln Val Pro 1325 1330 1335 Thr Phe Thr
Ile Pro Lys Leu Tyr Gln Leu Gln Val Pro Leu Leu 1340 1345 1350 Gly
Val Leu Asp Leu Ser Thr Asn Val Tyr Ser Asn Leu Tyr Asn 1355 1360
1365 Trp Ser Ala Ser Tyr Ser Gly Gly Asn Thr Ser Thr Asp His Phe
1370 1375 1380 Ser Leu Arg Ala Arg Tyr His Met Lys Ala Asp Ser Val
Val Asp 1385 1390 1395 Leu Leu Ser Tyr Asn Val Gln Gly Ser Gly Glu
Thr Thr Tyr Asp 1400 1405 1410 His Lys Asn Thr Phe Thr Leu Ser Cys
Asp Gly Ser Leu Arg His 1415 1420 1425 Lys Phe Leu Asp Ser Asn Ile
Lys Phe Ser His Val Glu Lys Leu 1430 1435 1440 Gly Asn Asn Pro Val
Ser Lys Gly Leu Leu Ile Phe Asp Ala Ser 1445 1450 1455 Ser Ser Trp
Gly Pro Gln Met Ser Ala Ser Val His Leu Asp Ser 1460 1465 1470 Lys
Lys Lys Gln His Leu Phe Val Lys Glu Val Lys Ile Asp Gly 1475 1480
1485 Gln Phe Arg Val Ser Ser Phe Tyr Ala Lys Gly Thr Tyr Gly Leu
1490 1495 1500 Ser Cys Gln Arg Asp Pro Asn Thr Gly Arg Leu Asn Gly
Glu Ser 1505 1510 1515 Asn Leu Arg Phe Asn Ser Ser Tyr Leu Gln Gly
Thr Asn Gln Ile 1520 1525 1530 Thr Gly Arg Tyr Glu Asp Gly Thr Leu
Ser Leu Thr Ser Thr Ser 1535 1540 1545 Asp Leu Gln Ser Gly Ile Ile
Lys Asn Thr Ala Ser Leu Lys Tyr 1550 1555 1560 Glu Asn Tyr Glu Leu
Thr Leu Lys Ser Asp Thr Asn Gly Lys Tyr 1565 1570 1575 Lys Asn Phe
Ala Thr Ser Asn Lys Met Asp Met Thr Phe Ser Lys 1580 1585 1590 Gln
Asn Ala Leu Leu Arg Ser Glu Tyr Gln Ala Asp Tyr Glu Ser 1595 1600
1605 Leu Arg Phe Phe Ser Leu Leu Ser Gly Ser Leu Asn Ser His Gly
1610 1615 1620 Leu Glu Leu Asn Ala Asp Ile Leu Gly Thr Asp Lys Ile
Asn Ser 1625 1630 1635 Gly Ala His Lys Ala Thr Leu Arg Ile Gly Gln
Asp Gly Ile Ser 1640 1645 1650 Thr Ser Ala Thr Thr Asn Leu Lys Cys
Ser Leu Leu Val Leu Glu 1655 1660 1665 Asn Glu Leu Asn Ala Glu Leu
Gly Leu Ser Gly Ala Ser Met Lys 1670 1675 1680 Leu Thr Thr Asn Gly
Arg Phe Arg Glu His Asn Ala Lys Phe Ser 1685 1690 1695 Leu Asp Gly
Lys Ala Ala Leu Thr Glu Leu Ser Leu Gly Ser Ala 1700 1705 1710 Tyr
Gln Ala Met Ile Leu Gly Val Asp Ser Lys Asn Ile Phe Asn 1715 1720
1725 Phe Lys Val Ser Gln Glu Gly Leu Lys Leu Ser Asn Asp Met Met
1730 1735 1740 Gly Ser Tyr Ala Glu Met Lys Phe Asp His Thr Asn Ser
Leu Asn 1745 1750 1755 Ile Ala Gly Leu Ser Leu Asp Phe Ser Ser Lys
Leu Asp Asn Ile 1760 1765 1770 Tyr Ser Ser Asp Lys Phe Tyr Lys Gln
Thr Val Asn Leu Gln Leu 1775 1780 1785 Gln Pro Tyr Ser Leu Val Thr
Thr Leu Asn Ser Asp Leu Lys Tyr 1790 1795 1800 Asn Ala Leu Asp Leu
Thr Asn Asn Gly Lys Leu Arg Leu Glu Pro 1805 1810 1815 Leu Lys Leu
His Val Ala Gly Asn Leu Lys Gly Ala Tyr Gln Asn 1820 1825 1830 Asn
Glu Ile Lys His Ile Tyr Ala Ile Ser Ser Ala Ala Leu Ser 1835 1840
1845 Ala Ser Tyr Lys Ala Asp Thr Val Ala Lys Val Gln Gly Val Glu
1850 1855 1860 Phe Ser His Arg Leu Asn Thr Asp Ile Ala Gly Leu Ala
Ser Ala 1865 1870 1875 Ile Asp Met Ser Thr Asn Tyr Asn Ser Asp Ser
Leu His Phe Ser 1880 1885 1890 Asn Val Phe Arg Ser Val Met Ala Pro
Phe Thr Met Thr Ile Asp 1895 1900 1905 Ala His Thr Asn Gly Asn Gly
Lys Leu Ala Leu Trp Gly Glu His 1910 1915 1920 Thr Gly Gln Leu Tyr
Ser Lys Phe Leu Leu Lys Ala Glu Pro Leu 1925 1930 1935 Ala Phe Thr
Phe Ser His Asp Tyr Lys Gly Ser Thr Ser His His 1940 1945 1950 Leu
Val Ser Arg Lys Ser Ile Ser Ala Ala Leu Glu His Lys Val 1955 1960
1965 Ser Ala Leu Leu Thr Pro Ala Glu Gln Thr Gly Thr Trp Lys Leu
1970 1975 1980 Lys Thr Gln Phe Asn Asn Asn Glu Tyr Ser Gln Asp Leu
Asp Ala 1985 1990 1995 Tyr Asn Thr Lys Asp Lys Ile Gly Val Glu Leu
Thr Gly Arg Thr 2000 2005 2010 Leu Ala Asp Leu Thr Leu Leu Asp Ser
Pro Ile Lys Val Pro Leu 2015 2020 2025 Leu Leu Ser Glu Pro Ile Asn
Ile Ile Asp Ala Leu Glu Met Arg 2030 2035 2040 Asp Ala Val Glu Lys
Pro Gln Glu Phe Thr Ile Val Ala Phe Val 2045 2050 2055 Lys Tyr Asp
Lys Asn Gln Asp Val His Ser Ile Asn Leu Pro Phe 2060 2065 2070 Phe
Glu Thr Leu Gln Glu Tyr Phe Glu Arg Asn Arg Gln Thr Ile 2075 2080
2085 Ile Val Val Val Glu Asn Val Gln Arg Asn Leu Lys His Ile Asn
2090 2095 2100 Ile Asp Gln Phe Val Arg Lys Tyr Arg Ala Ala Leu Gly
Lys Leu 2105 2110 2115 Pro Gln Gln Ala Asn Asp Tyr Leu Asn Ser Phe
Asn Trp Glu Arg 2120 2125 2130 Gln Val Ser His Ala Lys Glu Lys Leu
Thr Ala Leu Thr Lys Lys 2135 2140 2145 Tyr Arg Ile Thr Glu Asn Asp
Ile Gln Ile Ala Leu Asp Asp Ala 2150 2155 2160 Lys Ile Asn Phe Asn
Glu Lys Leu Ser Gln Leu Gln Thr Tyr Met 2165 2170 2175 Ile Gln Phe
Asp Gln Tyr Ile Lys Asp Ser Tyr Asp Leu His Asp 2180 2185 2190 Leu
Lys Ile Ala Ile Ala Asn Ile Ile Asp Glu Ile Ile Glu Lys 2195 2200
2205 Leu Lys Ser Leu Asp Glu His Tyr His Ile Arg Val Asn Leu Val
2210 2215 2220 Lys Thr Ile His Asp Leu His Leu Phe Ile Glu Asn Ile
Asp Phe 2225 2230 2235 Asn Lys Ser Gly Ser Ser Thr Ala Ser Trp Ile
Gln Asn Val Asp 2240 2245 2250 Thr Lys Tyr Gln Ile Arg Ile Gln Ile
Gln Glu Lys Leu Gln Gln 2255 2260 2265 Leu Lys Arg His Ile Gln Asn
Ile Asp Ile Gln His Leu Ala Gly 2270 2275 2280 Lys Leu Lys Gln His
Ile Glu Ala Ile Asp Val Arg Val Leu Leu 2285 2290 2295 Asp Gln Leu
Gly Thr Thr Ile Ser Phe Glu Arg Ile Asn Asp Val 2300 2305 2310 Leu
Glu His Val Lys His Phe Val Ile Asn Leu Ile Gly Asp Phe 2315 2320
2325 Glu Val Ala Glu Lys Ile Asn Ala Phe Arg Ala Lys Val His Glu
2330 2335 2340 Leu Ile Glu Arg Tyr Glu Val Asp Gln Gln Ile Gln Val
Leu Met 2345 2350 2355 Asp Lys Leu Val Glu Leu Thr His Gln Tyr Lys
Leu Lys Glu Thr 2360 2365 2370 Ile Gln Lys Leu Ser Asn Val Leu Gln
Gln Val Lys Ile Lys Asp 2375 2380 2385 Tyr Phe Glu Lys Leu Val Gly
Phe Ile Asp Asp Ala Val Lys Lys 2390 2395 2400 Leu Asn Glu Leu Ser
Phe Lys Thr Phe Ile Glu Asp Val Asn Lys 2405 2410 2415 Phe Leu Asp
Met Leu Ile Lys Lys Leu Lys Ser Phe Asp Tyr His 2420 2425 2430 Gln
Phe Val Asp Glu Thr Asn Asp Lys Ile Arg Glu Val Thr Gln 2435 2440
2445 Arg Leu Asn Gly Glu Ile Gln Ala Leu Glu Leu Pro Gln Lys Ala
2450 2455 2460 Glu Ala Leu Lys Leu Phe Leu Glu Glu Thr Lys Ala Thr
Val Ala 2465 2470 2475 Val Tyr Leu Glu Ser Leu Gln Asp Thr Lys Ile
Thr Leu Ile Ile 2480 2485 2490 Asn Trp Leu Gln Glu Ala Leu Ser Ser
Ala Ser Leu Ala His Met 2495 2500 2505 Lys Ala Lys Phe Arg Glu Thr
Leu Glu Asp Thr Arg Asp Arg Met 2510 2515 2520 Tyr Gln Met Asp Ile
Gln Gln Glu Leu Gln Arg Tyr Leu Ser Leu 2525 2530 2535 Val Gly Gln
Val Tyr Ser Thr Leu Val Thr Tyr Ile Ser Asp Trp 2540 2545 2550 Trp
Thr Leu Ala Ala Lys Asn Leu Thr Asp Phe Ala Glu Gln Tyr 2555 2560
2565 Ser Ile Gln Asp Trp Ala Lys Arg Met Lys Ala Leu Val Glu Gln
2570 2575 2580 Gly Phe Thr Val Pro Glu Ile Lys Thr Ile Leu Gly Thr
Met Pro 2585 2590 2595 Ala Phe Glu Val Ser Leu Gln Ala Leu Gln Lys
Ala Thr Phe Gln 2600 2605 2610 Thr Pro Asp Phe Ile Val Pro Leu Thr
Asp Leu Arg Ile Pro Ser 2615 2620 2625 Val Gln Ile Asn Phe Lys Asp
Leu Lys Asn Ile Lys Ile Pro Ser 2630 2635 2640 Arg Phe Ser Thr Pro
Glu Phe Thr Ile Leu Asn Thr Phe His Ile 2645 2650 2655 Pro Ser Phe
Thr Ile Asp Phe Val Glu Met Lys Val Lys Ile Ile 2660 2665 2670 Arg
Thr Ile Asp Gln Met Gln Asn Ser Glu Leu Gln Trp Pro Val 2675 2680
2685 Pro Asp Ile Tyr Leu Arg Asp Leu Lys Val Glu Asp Ile Pro Leu
2690 2695 2700 Ala Arg Ile Thr Leu Pro Asp Phe Arg Leu Pro Glu Ile
Ala Ile 2705 2710 2715 Pro Glu Phe Ile Ile Pro Thr Leu Asn Leu Asn
Asp Phe Gln Val 2720 2725 2730 Pro Asp Leu His Ile Pro Glu Phe Gln
Leu Pro His Ile Ser His 2735 2740 2745 Thr Ile Glu Val Pro Thr Phe
Gly Lys Leu Tyr Ser Ile Leu Lys 2750 2755 2760 Ile Gln Ser Pro Leu
Phe Thr Leu Asp Ala Asn Ala Asp Ile Gly 2765 2770 2775 Asn Gly Thr
Thr Ser Ala Asn Glu Ala Gly Ile Ala Ala Ser Ile 2780 2785 2790 Thr
Ala Lys Gly Glu Ser Lys Leu Glu Val Leu Asn Phe Asp Phe 2795 2800
2805 Gln Ala Asn Ala Gln Leu Ser Asn Pro Lys Ile Asn Pro Leu Ala
2810 2815 2820 Leu Lys Glu Ser Val Lys Phe Ser Ser Lys Tyr Leu Arg
Thr Glu 2825 2830 2835 His Gly Ser Glu Met Leu Phe Phe Gly Asn Ala
Ile Glu Gly Lys 2840 2845 2850 Ser Asn Thr Val Ala Ser Leu His Thr
Glu Lys Asn Thr Leu Glu 2855 2860 2865 Leu Ser Asn Gly Val Ile Val
Lys Ile Asn Asn Gln Leu Thr Leu 2870 2875 2880 Asp Ser Asn Thr Lys
Tyr Phe His Lys Leu Asn Ile Pro Lys Leu 2885 2890 2895 Asp Phe Ser
Ser Gln Ala Asp Leu Arg Asn Glu Ile Lys Thr Leu 2900 2905 2910 Leu
Lys Ala Gly His Ile Ala Trp Thr Ser Ser Gly Lys Gly Ser 2915 2920
2925 Trp Lys Trp Ala Cys Pro Arg Phe Ser Asp Glu Gly Thr His Glu
2930 2935 2940 Ser Gln Ile Ser Phe Thr Ile Glu Gly Pro Leu Thr Ser
Phe Gly 2945 2950 2955 Leu Ser Asn Lys Ile Asn Ser Lys His Leu Arg
Val Asn Gln Asn 2960 2965 2970 Leu Val Tyr Glu Ser Gly Ser Leu Asn
Phe Ser Lys Leu Glu Ile 2975 2980 2985 Gln Ser Gln Val Asp Ser Gln
His Val Gly His Ser Val Leu Thr 2990 2995 3000 Ala Lys Gly Met Ala
Leu Phe Gly Glu Gly Lys Ala Glu Phe Thr 3005 3010 3015 Gly Arg His
Asp Ala His Leu Asn Gly Lys Val Ile Gly Thr Leu 3020 3025 3030 Lys
Asn Ser Leu Phe Phe Ser Ala Gln Pro Phe Glu Ile Thr Ala 3035 3040
3045 Ser Thr Asn Asn Glu Gly Asn Leu Lys Val Arg Phe Pro Leu Arg
3050 3055 3060 Leu Thr Gly Lys Ile Asp Phe Leu Asn Asn Tyr Ala Leu
Phe Leu 3065 3070 3075 Ser Pro Ser Ala Gln Gln Ala Ser Trp Gln Val
Ser Ala Arg Phe 3080 3085 3090 Asn Gln Tyr Lys Tyr Asn Gln Asn Phe
Ser Ala Gly Asn Asn Glu 3095 3100 3105 Asn Ile Met Glu Ala His Val
Gly Ile Asn Gly Glu Ala Asn Leu 3110 3115 3120 Asp Phe Leu Asn Ile
Pro Leu Thr Ile Pro Glu Met Arg Leu Pro 3125 3130 3135 Tyr Thr Ile
Ile Thr Thr Pro Pro Leu Lys Asp Phe Ser Leu Trp 3140 3145 3150 Glu
Lys Thr Gly Leu Lys Glu Phe Leu Lys Thr Thr Lys Gln Ser 3155 3160
3165 Phe Asp Leu Ser Val Lys Ala Gln Tyr Lys Lys Asn Lys His Arg
3170 3175 3180 His Ser Ile Thr Asn Pro Leu Ala Val Leu Cys Glu Phe
Ile Ser 3185 3190 3195 Gln Ser Ile Lys Ser Phe Asp Arg His Phe Glu
Lys Asn Arg Asn 3200 3205 3210 Asn Ala Leu Asp Phe Val Thr Lys Ser
Tyr Asn Glu Thr Lys Ile 3215 3220 3225 Lys Phe Asp Lys Tyr Lys Ala
Glu Lys Ser His Asp Glu Leu Pro 3230 3235 3240 Arg Thr Phe Gln Ile
Pro Gly Tyr Thr Val Pro Val Val Asn Val 3245 3250 3255 Glu Val Ser
Pro Phe Thr Ile Glu Met Ser Ala Phe Gly Tyr Val 3260 3265 3270 Phe
Pro Lys Ala Val Ser Met Pro Ser Phe Ser Ile Leu Gly Ser 3275 3280
3285 Asp Val Arg Val Pro Ser Tyr Thr Leu Ile Leu Pro Ser Leu Glu
3290 3295 3300 Leu Pro Val Leu His Val Pro Arg Asn Leu Lys Leu Ser
Leu Pro 3305 3310 3315 His Phe Lys Glu Leu Cys Thr Ile Ser His Ile
Phe Ile Pro Ala 3320 3325 3330 Met Gly Asn Ile Thr Tyr Asp Phe Ser
Phe Lys Ser Ser Val Ile 3335 3340 3345 Thr Leu Asn Thr Asn Ala Glu
Leu Phe Asn Gln Ser Asp Ile Val 3350 3355 3360 Ala His Leu Leu Ser
Ser Ser Ser Ser Val Ile Asp Ala Leu Gln 3365 3370 3375 Tyr Lys Leu
Glu Gly Thr Thr Arg Leu Thr Arg Lys Arg Gly Leu 3380
3385 3390 Lys Leu Ala Thr Ala Leu Ser Leu Ser Asn Lys Phe Val Glu
Gly 3395 3400 3405 Ser His Asn Ser Thr Val Ser Leu Thr Thr Lys Asn
Met Glu Val 3410 3415 3420 Ser Val Ala Lys Thr Thr Lys Ala Glu Ile
Pro Ile Leu Arg Met 3425 3430 3435 Asn Phe Lys Gln Glu Leu Asn Gly
Asn Thr Lys Ser Lys Pro Thr 3440 3445 3450 Val Ser Ser Ser Met Glu
Phe Lys Tyr Asp Phe Asn Ser Ser Met 3455 3460 3465 Leu Tyr Ser Thr
Ala Lys Gly Ala Val Asp His Lys Leu Ser Leu 3470 3475 3480 Glu Ser
Leu Thr Ser Tyr Phe Ser Ile Glu Ser Ser Thr Lys Gly 3485 3490 3495
Asp Val Lys Gly Ser Val Leu Ser Arg Glu Tyr Ser Gly Thr Ile 3500
3505 3510 Ala Ser Glu Ala Asn Thr Tyr Leu Asn Ser Lys Ser Thr Arg
Ser 3515 3520 3525 Ser Val Lys Leu Gln Gly Thr Ser Lys Ile Asp Asp
Ile Trp Asn 3530 3535 3540 Leu Glu Val Lys Glu Asn Phe Ala Gly Glu
Ala Thr Leu Gln Arg 3545 3550 3555 Ile Tyr Ser Leu Trp Glu His Ser
Thr Lys Asn His Leu Gln Leu 3560 3565 3570 Glu Gly Leu Phe Phe Thr
Asn Gly Glu His Thr Ser Lys Ala Thr 3575 3580 3585 Leu Glu Leu Ser
Pro Trp Gln Met Ser Ala Leu Val Gln Val His 3590 3595 3600 Ala Ser
Gln Pro Ser Ser Phe His Asp Phe Pro Asp Leu Gly Gln 3605 3610 3615
Glu Val Ala Leu Asn Ala Asn Thr Lys Asn Gln Lys Ile Arg Trp 3620
3625 3630 Lys Asn Glu Val Arg Ile His Ser Gly Ser Phe Gln Ser Gln
Val 3635 3640 3645 Glu Leu Ser Asn Asp Gln Glu Lys Ala His Leu Asp
Ile Ala Gly 3650 3655 3660 Ser Leu Glu Gly His Leu Arg Phe Leu Lys
Asn Ile Ile Leu Pro 3665 3670 3675 Val Tyr Asp Lys Ser Leu Trp Asp
Phe Leu Lys Leu Asp Val Thr 3680 3685 3690 Thr Ser Ile Gly Arg Arg
Gln His Leu Arg Val Ser Thr Ala Phe 3695 3700 3705 Val Tyr Thr Lys
Asn Pro Asn Gly Tyr Ser Phe Ser Ile Pro Val 3710 3715 3720 Lys Val
Leu Ala Asp Lys Phe Ile Thr Pro Gly Leu Lys Leu Asn 3725 3730 3735
Asp Leu Asn Ser Val Leu Val Met Pro Thr Phe His Val Pro Phe 3740
3745 3750 Thr Asp Leu Gln Val Pro Ser Cys Lys Leu Asp Phe Arg Glu
Ile 3755 3760 3765 Gln Ile Tyr Lys Lys Leu Arg Thr Ser Ser Phe Ala
Leu Asn Leu 3770 3775 3780 Pro Thr Leu Pro Glu Val Lys Phe Pro Glu
Val Asp Val Leu Thr 3785 3790 3795 Lys Tyr Ser Gln Pro Glu Asp Ser
Leu Ile Pro Phe Phe Glu Ile 3800 3805 3810 Thr Val Pro Glu Ser Gln
Leu Thr Val Ser Gln Phe Thr Leu Pro 3815 3820 3825 Lys Ser Val Ser
Asp Gly Ile Ala Ala Leu Asp Leu Asn Ala Val 3830 3835 3840 Ala Asn
Lys Ile Ala Asp Phe Glu Leu Pro Thr Ile Ile Val Pro 3845 3850 3855
Glu Gln Thr Ile Glu Ile Pro Ser Ile Lys Phe Ser Val Pro Ala 3860
3865 3870 Gly Ile Val Ile Pro Ser Phe Gln Ala Leu Thr Ala Arg Phe
Glu 3875 3880 3885 Val Asp Ser Pro Val Tyr Asn Ala Thr Trp Ser Ala
Ser Leu Lys 3890 3895 3900 Asn Lys Ala Asp Tyr Val Glu Thr Val Leu
Asp Ser Thr Cys Ser 3905 3910 3915 Ser Thr Val Gln Phe Leu Glu Tyr
Glu Leu Asn Val Leu Gly Thr 3920 3925 3930 His Lys Ile Glu Asp Gly
Thr Leu Ala Ser Lys Thr Lys Gly Thr 3935 3940 3945 Leu Ala His Arg
Asp Phe Ser Ala Glu Tyr Glu Glu Asp Gly Lys 3950 3955 3960 Phe Glu
Gly Leu Gln Glu Trp Glu Gly Lys Ala His Leu Asn Ile 3965 3970 3975
Lys Ser Pro Ala Phe Thr Asp Leu His Leu Arg Tyr Gln Lys Asp 3980
3985 3990 Lys Lys Gly Ile Ser Thr Ser Ala Ala Ser Pro Ala Val Gly
Thr 3995 4000 4005 Val Gly Met Asp Met Asp Glu Asp Asp Asp Phe Ser
Lys Trp Asn 4010 4015 4020 Phe Tyr Tyr Ser Pro Gln Ser Ser Pro Asp
Lys Lys Leu Thr Ile 4025 4030 4035 Phe Lys Thr Glu Leu Arg Val Arg
Glu Ser Asp Glu Glu Thr Gln 4040 4045 4050 Ile Lys Val Asn Trp Glu
Glu Glu Ala Ala Ser Gly Leu Leu Thr 4055 4060 4065 Ser Leu Lys Asp
Asn Val Pro Lys Ala Thr Gly Val Leu Tyr Asp 4070 4075 4080 Tyr Val
Asn Lys Tyr His Trp Glu His Thr Gly Leu Thr Leu Arg 4085 4090 4095
Glu Val Ser Ser Lys Leu Arg Arg Asn Leu Gln Asn Asn Ala Glu 4100
4105 4110 Trp Val Tyr Gln Gly Ala Ile Arg Gln Ile Asp Asp Ile Asp
Val 4115 4120 4125 Arg Phe Gln Lys Ala Ala Ser Gly Thr Thr Gly Thr
Tyr Gln Glu 4130 4135 4140 Trp Lys Asp Lys Ala Gln Asn Leu Tyr Gln
Glu Leu Leu Thr Gln 4145 4150 4155 Glu Gly Gln Ala Ser Phe Gln Gly
Leu Lys Asp Asn Val Phe Asp 4160 4165 4170 Gly Leu Val Arg Val Thr
Gln Lys Phe His Met Lys Val Lys His 4175 4180 4185 Leu Ile Asp Ser
Leu Ile Asp Phe Leu Asn Phe Pro Arg Phe Gln 4190 4195 4200 Phe Pro
Gly Lys Pro Gly Ile Tyr Thr Arg Glu Glu Leu Cys Thr 4205 4210 4215
Met Phe Ile Arg Glu Val Gly Thr Val Leu Ser Gln Val Tyr Ser 4220
4225 4230 Lys Val His Asn Gly Ser Glu Ile Leu Phe Ser Tyr Phe Gln
Asp 4235 4240 4245 Leu Val Ile Thr Leu Pro Phe Glu Leu Arg Lys His
Lys Leu Ile 4250 4255 4260 Asp Val Ile Ser Met Tyr Arg Glu Leu Leu
Lys Asp Leu Ser Lys 4265 4270 4275 Glu Ala Gln Glu Val Phe Lys Ala
Ile Gln Ser Leu Lys Thr Thr 4280 4285 4290 Glu Val Leu Arg Asn Leu
Gln Asp Leu Leu Gln Phe Ile Phe Gln 4295 4300 4305 Leu Ile Glu Asp
Asn Ile Lys Gln Leu Lys Glu Met Lys Phe Thr 4310 4315 4320 Tyr Leu
Ile Asn Tyr Ile Gln Asp Glu Ile Asn Thr Ile Phe Asn 4325 4330 4335
Asp Tyr Ile Pro Tyr Val Phe Lys Leu Leu Lys Glu Asn Leu Cys 4340
4345 4350 Leu Asn Leu His Lys Phe Asn Glu Phe Ile Gln Asn Glu Leu
Gln 4355 4360 4365 Glu Ala Ser Gln Glu Leu Gln Gln Ile His Gln Tyr
Ile Met Ala 4370 4375 4380 Leu Arg Glu Glu Tyr Phe Asp Pro Ser Ile
Val Gly Trp Thr Val 4385 4390 4395 Lys Tyr Tyr Glu Leu Glu Glu Lys
Ile Val Ser Leu Ile Lys Asn 4400 4405 4410 Leu Leu Val Ala Leu Lys
Asp Phe His Ser Glu Tyr Ile Val Ser 4415 4420 4425 Ala Ser Asn Phe
Thr Ser Gln Leu Ser Ser Gln Val Glu Gln Phe 4430 4435 4440 Leu His
Arg Asn Ile Gln Glu Tyr Leu Ser Ile Leu Thr Asp Pro 4445 4450 4455
Asp Gly Lys Gly Lys Glu Lys Ile Ala Glu Leu Ser Ala Thr Ala 4460
4465 4470 Gln Glu Ile Ile Lys Ser Gln Ala Ile Ala Thr Lys Lys Ile
Ile 4475 4480 4485 Ser Asp Tyr His Gln Gln Phe Arg Tyr Lys Leu Gln
Asp Phe Ser 4490 4495 4500 Asp Gln Leu Ser Asp Tyr Tyr Glu Lys Phe
Ile Ala Glu Ser Lys 4505 4510 4515 Arg Leu Ile Asp Leu Ser Ile Gln
Asn Tyr His Thr Phe Leu Ile 4520 4525 4530 Tyr Ile Thr Glu Leu Leu
Lys Lys Leu Gln Ser Thr Thr Val Met 4535 4540 4545 Asn Pro Tyr Met
Lys Leu Ala Pro Gly Glu Leu Thr Ile Ile Leu 4550 4555 4560
27883PRTHomo sapiens 278Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val
Val Val Leu Ser Ile 1 5 10 15 Val Leu Glu Gly Pro Ala Pro Ala Gln
Gly Thr Pro Asp Val Ser Ser 20 25 30 Ala Leu Asp Lys Leu Lys Glu
Phe Gly Asn Thr Leu Glu Asp Lys Ala 35 40 45 Arg Glu Leu Ile Ser
Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 50 55 60 Arg Glu Trp
Phe Ser Glu Thr Phe Gln Lys Val Lys Glu Lys Leu Lys 65 70 75 80 Ile
Asp Ser 279317PRTHomo sapiens 279Met Lys Val Leu Trp Ala Ala Leu
Leu Val Thr Phe Leu Ala Gly Cys 1 5 10 15 Gln Ala Lys Val Glu Gln
Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 20 25 30 Arg Gln Gln Thr
Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 35 40 45 Gly Arg
Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 50 55 60
Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 65
70 75 80 Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser
Glu Leu 85 90 95 Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg
Ala Arg Leu Ser 100 105 110 Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu
Gly Ala Asp Met Glu Asp 115 120 125 Val Cys Gly Arg Leu Val Gln Tyr
Arg Gly Glu Val Gln Ala Met Leu 130 135 140 Gly Gln Ser Thr Glu Glu
Leu Arg Val Arg Leu Ala Ser His Leu Arg 145 150 155 160 Lys Leu Arg
Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 165 170 175 Leu
Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 180 185
190 Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val
195 200 205 Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln
Glu Arg 210 215 220 Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met
Glu Glu Met Gly 225 230 235 240 Ser Arg Thr Arg Asp Arg Leu Asp Glu
Val Lys Glu Gln Val Ala Glu 245 250 255 Val Arg Ala Lys Leu Glu Glu
Gln Ala Gln Gln Ile Arg Leu Gln Ala 260 265 270 Glu Ala Phe Gln Ala
Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 275 280 285 Asp Met Gln
Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 290 295 300 Val
Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 305 310 315
280345PRTHomo sapiens 280Met Ile Ser Pro Val Leu Ile Leu Phe Ser
Ser Phe Leu Cys His Val 1 5 10 15 Ala Ile Ala Gly Arg Thr Cys Pro
Lys Pro Asp Asp Leu Pro Phe Ser 20 25 30 Thr Val Val Pro Leu Lys
Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr 35 40 45 Tyr Ser Cys Lys
Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe 50 55 60 Ile Cys
Pro Leu Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr 65 70 75 80
Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg 85
90 95 Tyr Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn
Thr 100 105 110 Gly Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr
Glu Glu Gly 115 120 125 Lys Trp Ser Pro Glu Leu Pro Val Cys Ala Pro
Ile Ile Cys Pro Pro 130 135 140 Pro Ser Ile Pro Thr Phe Ala Thr Leu
Arg Val Tyr Lys Pro Ser Ala 145 150 155 160 Gly Asn Asn Ser Leu Tyr
Arg Asp Thr Ala Val Phe Glu Cys Leu Pro 165 170 175 Gln His Ala Met
Phe Gly Asn Asp Thr Ile Thr Cys Thr Thr His Gly 180 185 190 Asn Trp
Thr Lys Leu Pro Glu Cys Arg Glu Val Lys Cys Pro Phe Pro 195 200 205
Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr Pro Ala Lys Pro Thr Leu 210
215 220 Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Asp Gly Tyr Ser
Leu 225 230 235 240 Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys Leu Gly
Asn Trp Ser Ala 245 250 255 Met Pro Ser Cys Lys Ala Ser Cys Lys Leu
Pro Val Lys Lys Ala Thr 260 265 270 Val Val Tyr Gln Gly Glu Arg Val
Lys Ile Gln Glu Lys Phe Lys Asn 275 280 285 Gly Met Leu His Gly Asp
Lys Val Ser Phe Phe Cys Lys Asn Lys Glu 290 295 300 Lys Lys Cys Ser
Tyr Thr Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile 305 310 315 320 Glu
Val Pro Lys Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys 325 330
335 Thr Asp Ala Ser Asp Val Lys Pro Cys 340 345 281543PRTHomo
sapiens 281Met Ala His Ala His Ile Gln Gly Gly Arg Arg Ala Lys Ser
Arg Phe 1 5 10 15 Val Val Cys Ile Met Ser Gly Ala Arg Ser Lys Leu
Ala Leu Phe Leu 20 25 30 Cys Gly Cys Tyr Val Val Ala Leu Gly Ala
His Thr Gly Glu Glu Ser 35 40 45 Val Ala Asp His His Glu Ala Glu
Tyr Tyr Val Ala Ala Val Tyr Glu 50 55 60 His Pro Ser Ile Leu Ser
Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln 65 70 75 80 Glu Ala Leu Glu
Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln 85 90 95 Val Met
Thr Ala Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu 100 105 110
Asp Gly Ile His Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe 115
120 125 Leu Asp Phe Met Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys
Leu 130 135 140 Glu Pro His Arg Phe Asn Asp Thr Glu Val Leu Gln Arg
Leu Ser Cys 145 150 155 160 Met Ala Ile Arg Gly Asp Met Phe Leu Val
Ala Asn Leu Gly Thr Lys 165 170 175 Glu Pro Cys His Ser Ser Asp Pro
Arg Cys Pro Lys Asp Gly Arg Tyr 180 185 190 Gln Phe Asn Thr Asn Val
Val Phe Ser Asn Asn Gly Thr Leu Val Asp 195 200 205 Arg Tyr Arg Lys
His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro 210 215 220 Leu Lys
Val Asp Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe 225 230 235
240 Gly Ile Phe Thr Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg
245 250 255 Val Leu Arg Asp Tyr Lys Val Lys His Val Val Tyr Pro Thr
Ala Trp 260 265 270 Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile
Gln Lys Ala Phe 275 280 285 Ala Val Ala Phe Gly Ile Asn Val Leu Ala
Ala Asn Val His His Pro 290 295 300 Val Leu Gly Met Thr Gly Ser Gly
Ile His Thr Pro Leu Glu Ser Phe 305 310
315 320 Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala
Gln 325 330 335 Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn
Ala Thr Gly 340 345 350 Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys
Ile Leu Ser Gly Asp 355 360 365 Pro Tyr Cys Glu Lys Asp Ala Gln Glu
Val His Cys Asp Glu Ala Thr 370 375 380 Lys Trp Asn Val Asn Ala Pro
Pro Thr Phe His Ser Glu Met Met Tyr 385 390 395 400 Asp Asn Phe Thr
Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His 405 410 415 Val Cys
Ser Asn Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr 420 425 430
Leu Ser Lys Glu Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr 435
440 445 Val His Gly Thr Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys
Gly 450 455 460 Gly Leu Gly Phe Asp Thr Cys Gly Gln Glu Ile Thr Glu
Ala Thr Gly 465 470 475 480 Ile Phe Glu Phe His Leu Trp Gly Asn Phe
Ser Thr Ser Tyr Ile Phe 485 490 495 Pro Leu Phe Leu Thr Ser Gly Met
Thr Leu Glu Val Pro Asp Gln Leu 500 505 510 Gly Trp Glu Asn Asp His
Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser 515 520 525 Gly Leu Val Thr
Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp 530 535 540
282261PRTHomo sapiens 282Met Ala Ser Pro Asp Trp Gly Tyr Asp Asp
Lys Asn Gly Pro Glu Gln 1 5 10 15 Trp Ser Lys Leu Tyr Pro Ile Ala
Asn Gly Asn Asn Gln Ser Pro Val 20 25 30 Asp Ile Lys Thr Ser Glu
Thr Lys His Asp Thr Ser Leu Lys Pro Ile 35 40 45 Ser Val Ser Tyr
Asn Pro Ala Thr Ala Lys Glu Ile Ile Asn Val Gly 50 55 60 His Ser
Phe His Val Asn Phe Glu Asp Asn Asp Asn Arg Ser Val Leu 65 70 75 80
Lys Gly Gly Pro Phe Ser Asp Ser Tyr Arg Leu Phe Gln Phe His Phe 85
90 95 His Trp Gly Ser Thr Asn Glu His Gly Ser Glu His Thr Val Asp
Gly 100 105 110 Val Lys Tyr Ser Ala Glu Leu His Val Ala His Trp Asn
Ser Ala Lys 115 120 125 Tyr Ser Ser Leu Ala Glu Ala Ala Ser Lys Ala
Asp Gly Leu Ala Val 130 135 140 Ile Gly Val Leu Met Lys Val Gly Glu
Ala Asn Pro Lys Leu Gln Lys 145 150 155 160 Val Leu Asp Ala Leu Gln
Ala Ile Lys Thr Lys Gly Lys Arg Ala Pro 165 170 175 Phe Thr Asn Phe
Asp Pro Ser Thr Leu Leu Pro Ser Ser Leu Asp Phe 180 185 190 Trp Thr
Tyr Pro Gly Ser Leu Thr His Pro Pro Leu Tyr Glu Ser Val 195 200 205
Thr Trp Ile Ile Cys Lys Glu Ser Ile Ser Val Ser Ser Glu Gln Leu 210
215 220 Ala Gln Phe Arg Ser Leu Leu Ser Asn Val Glu Gly Asp Asn Ala
Val 225 230 235 240 Pro Met Gln His Asn Asn Arg Pro Thr Gln Pro Leu
Lys Gly Arg Thr 245 250 255 Val Arg Ala Ser Phe 260 283458PRTHomo
sapiens 283Met Ser Asp Leu Leu Ser Val Phe Leu His Leu Leu Leu Leu
Phe Lys 1 5 10 15 Leu Val Ala Pro Val Thr Phe Arg His His Arg Tyr
Asp Asp Leu Val 20 25 30 Arg Thr Leu Tyr Lys Val Gln Asn Glu Cys
Pro Gly Ile Thr Arg Val 35 40 45 Tyr Ser Ile Gly Arg Ser Val Glu
Gly Arg His Leu Tyr Val Leu Glu 50 55 60 Phe Ser Asp His Pro Gly
Ile His Glu Pro Leu Glu Pro Glu Val Lys 65 70 75 80 Tyr Val Gly Asn
Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met 85 90 95 Leu Gln
Leu Ser Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln 100 105 110
Arg Ile Val Gln Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser 115
120 125 Met Asn Pro Asp Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn
Lys 130 135 140 Pro Gly Tyr Leu Val Gly Arg Asn Asn Ala Asn Gly Val
Asp Leu Asn 145 150 155 160 Arg Asn Phe Pro Asp Leu Asn Thr Tyr Ile
Tyr Tyr Asn Glu Lys Tyr 165 170 175 Gly Gly Pro Asn His His Leu Pro
Leu Pro Asp Asn Trp Lys Ser Gln 180 185 190 Val Glu Pro Glu Thr Arg
Ala Val Ile Arg Trp Met His Ser Phe Asn 195 200 205 Phe Val Leu Ser
Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr 210 215 220 Pro Tyr
Asp Lys Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr 225 230 235
240 Ala Ser Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys
245 250 255 Val Tyr Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn
Cys Gly 260 265 270 Asp Tyr Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser
Trp Tyr Ser Leu 275 280 285 Ser Lys Gly Met Gln Asp Phe Asn Tyr Leu
His Thr Asn Cys Phe Glu 290 295 300 Ile Thr Leu Glu Leu Ser Cys Asp
Lys Phe Pro Pro Glu Glu Glu Leu 305 310 315 320 Gln Arg Glu Trp Leu
Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu 325 330 335 Gln Val His
Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn 340 345 350 Asn
Leu Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val 355 360
365 Thr Ser Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile
370 375 380 Tyr Thr Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr
Val Thr 385 390 395 400 Val Thr Val Gly Pro Ala Glu Pro Thr Leu Val
Asn Phe His Leu Lys 405 410 415 Arg Ser Ile Pro Gln Val Ser Pro Val
Arg Arg Ala Pro Ser Arg Arg 420 425 430 His Gly Val Arg Ala Lys Val
Gln Pro Gln Ala Arg Lys Lys Glu Met 435 440 445 Glu Met Arg Gln Leu
Gln Arg Gly Pro Ala 450 455 2841065PRTHomo sapiens 284Met Lys Ile
Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 1 5 10 15 Ala
Trp Ala Lys Glu Lys His Tyr Tyr Ile Gly Ile Ile Glu Thr Thr 20 25
30 Trp Asp Tyr Ala Ser Asp His Gly Glu Lys Lys Leu Ile Ser Val Asp
35 40 45 Thr Glu His Ser Asn Ile Tyr Leu Gln Asn Gly Pro Asp Arg
Ile Gly 50 55 60 Arg Leu Tyr Lys Lys Ala Leu Tyr Leu Gln Tyr Thr
Asp Glu Thr Phe 65 70 75 80 Arg Thr Thr Ile Glu Lys Pro Val Trp Leu
Gly Phe Leu Gly Pro Ile 85 90 95 Ile Lys Ala Glu Thr Gly Asp Lys
Val Tyr Val His Leu Lys Asn Leu 100 105 110 Ala Ser Arg Pro Tyr Thr
Phe His Ser His Gly Ile Thr Tyr Tyr Lys 115 120 125 Glu His Glu Gly
Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg 130 135 140 Ala Asp
Asp Lys Val Tyr Pro Gly Glu Gln Tyr Thr Tyr Met Leu Leu 145 150 155
160 Ala Thr Glu Glu Gln Ser Pro Gly Glu Gly Asp Gly Asn Cys Val Thr
165 170 175 Arg Ile Tyr His Ser His Ile Asp Ala Pro Lys Asp Ile Ala
Ser Gly 180 185 190 Leu Ile Gly Pro Leu Ile Ile Cys Lys Lys Asp Ser
Leu Asp Lys Glu 195 200 205 Lys Glu Lys His Ile Asp Arg Glu Phe Val
Val Met Phe Ser Val Val 210 215 220 Asp Glu Asn Phe Ser Trp Tyr Leu
Glu Asp Asn Ile Lys Thr Tyr Cys 225 230 235 240 Ser Glu Pro Glu Lys
Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser 245 250 255 Asn Arg Met
Tyr Ser Val Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly 260 265 270 Leu
Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met 275 280
285 Gly Asn Glu Val Asp Val His Ala Ala Phe Phe His Gly Gln Ala Leu
290 295 300 Thr Asn Lys Asn Tyr Arg Ile Asp Thr Ile Asn Leu Phe Pro
Ala Thr 305 310 315 320 Leu Phe Asp Ala Tyr Met Val Ala Gln Asn Pro
Gly Glu Trp Met Leu 325 330 335 Ser Cys Gln Asn Leu Asn His Leu Lys
Ala Gly Leu Gln Ala Phe Phe 340 345 350 Gln Val Gln Glu Cys Asn Lys
Ser Ser Ser Lys Asp Asn Ile Arg Gly 355 360 365 Lys His Val Arg His
Tyr Tyr Ile Ala Ala Glu Glu Ile Ile Trp Asn 370 375 380 Tyr Ala Pro
Ser Gly Ile Asp Ile Phe Thr Lys Glu Asn Leu Thr Ala 385 390 395 400
Pro Gly Ser Asp Ser Ala Val Phe Phe Glu Gln Gly Thr Thr Arg Ile 405
410 415 Gly Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp Ala
Ser 420 425 430 Phe Thr Asn Arg Lys Glu Arg Gly Pro Glu Glu Glu His
Leu Gly Ile 435 440 445 Leu Gly Pro Val Ile Trp Ala Glu Val Gly Asp
Thr Ile Arg Val Thr 450 455 460 Phe His Asn Lys Gly Ala Tyr Pro Leu
Ser Ile Glu Pro Ile Gly Val 465 470 475 480 Arg Phe Asn Lys Asn Asn
Glu Gly Thr Tyr Tyr Ser Pro Asn Tyr Asn 485 490 495 Pro Gln Ser Arg
Ser Val Pro Pro Ser Ala Ser His Val Ala Pro Thr 500 505 510 Glu Thr
Phe Thr Tyr Glu Trp Thr Val Pro Lys Glu Val Gly Pro Thr 515 520 525
Asn Ala Asp Pro Val Cys Leu Ala Lys Met Tyr Tyr Ser Ala Val Asp 530
535 540 Pro Thr Lys Asp Ile Phe Thr Gly Leu Ile Gly Pro Met Lys Ile
Cys 545 550 555 560 Lys Lys Gly Ser Leu His Ala Asn Gly Arg Gln Lys
Asp Val Asp Lys 565 570 575 Glu Phe Tyr Leu Phe Pro Thr Val Phe Asp
Glu Asn Glu Ser Leu Leu 580 585 590 Leu Glu Asp Asn Ile Arg Met Phe
Thr Thr Ala Pro Asp Gln Val Asp 595 600 605 Lys Glu Asp Glu Asp Phe
Gln Glu Ser Asn Lys Met His Ser Met Asn 610 615 620 Gly Phe Met Tyr
Gly Asn Gln Pro Gly Leu Thr Met Cys Lys Gly Asp 625 630 635 640 Ser
Val Val Trp Tyr Leu Phe Ser Ala Gly Asn Glu Ala Asp Val His 645 650
655 Gly Ile Tyr Phe Ser Gly Asn Thr Tyr Leu Trp Arg Gly Glu Arg Arg
660 665 670 Asp Thr Ala Asn Leu Phe Pro Gln Thr Ser Leu Thr Leu His
Met Trp 675 680 685 Pro Asp Thr Glu Gly Thr Phe Asn Val Glu Cys Leu
Thr Thr Asp His 690 695 700 Tyr Thr Gly Gly Met Lys Gln Lys Tyr Thr
Val Asn Gln Cys Arg Arg 705 710 715 720 Gln Ser Glu Asp Ser Thr Phe
Tyr Leu Gly Glu Arg Thr Tyr Tyr Ile 725 730 735 Ala Ala Val Glu Val
Glu Trp Asp Tyr Ser Pro Gln Arg Glu Trp Glu 740 745 750 Lys Glu Leu
His His Leu Gln Glu Gln Asn Val Ser Asn Ala Phe Leu 755 760 765 Asp
Lys Gly Glu Phe Tyr Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr 770 775
780 Arg Gln Tyr Thr Asp Ser Thr Phe Arg Val Pro Val Glu Arg Lys Ala
785 790 795 800 Glu Glu Glu His Leu Gly Ile Leu Gly Pro Gln Leu His
Ala Asp Val 805 810 815 Gly Asp Lys Val Lys Ile Ile Phe Lys Asn Met
Ala Thr Arg Pro Tyr 820 825 830 Ser Ile His Ala His Gly Val Gln Thr
Glu Ser Ser Thr Val Thr Pro 835 840 845 Thr Leu Pro Gly Glu Thr Leu
Thr Tyr Val Trp Lys Ile Pro Glu Arg 850 855 860 Ser Gly Ala Gly Thr
Glu Asp Ser Ala Cys Ile Pro Trp Ala Tyr Tyr 865 870 875 880 Ser Thr
Val Asp Gln Val Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro 885 890 895
Leu Ile Val Cys Arg Arg Pro Tyr Leu Lys Val Phe Asn Pro Arg Arg 900
905 910 Lys Leu Glu Phe Ala Leu Leu Phe Leu Val Phe Asp Glu Asn Glu
Ser 915 920 925 Trp Tyr Leu Asp Asp Asn Ile Lys Thr Tyr Ser Asp His
Pro Glu Lys 930 935 940 Val Asn Lys Asp Asp Glu Glu Phe Ile Glu Ser
Asn Lys Met His Ala 945 950 955 960 Ile Asn Gly Arg Met Phe Gly Asn
Leu Gln Gly Leu Thr Met His Val 965 970 975 Gly Asp Glu Val Asn Trp
Tyr Leu Met Gly Met Gly Asn Glu Ile Asp 980 985 990 Leu His Thr Val
His Phe His Gly His Ser Phe Gln Tyr Lys His Arg 995 1000 1005 Gly
Val Tyr Ser Ser Asp Val Phe Asp Ile Phe Pro Gly Thr Tyr 1010 1015
1020 Gln Thr Leu Glu Met Phe Pro Arg Thr Pro Gly Ile Trp Leu Leu
1025 1030 1035 His Cys His Val Thr Asp His Ile His Ala Gly Met Glu
Thr Thr 1040 1045 1050 Tyr Thr Val Leu Gln Asn Glu Asp Thr Lys Ser
Gly 1055 1060 1065 285501PRTHomo sapiens 285Met Gln Val Cys Ser Gln
Pro Gln Arg Gly Cys Val Arg Glu Gln Ser 1 5 10 15 Ala Ile Asn Thr
Ala Pro Pro Ser Ala His Asn Ala Ala Ser Pro Gly 20 25 30 Gly Ala
Arg Gly His Arg Val Pro Leu Thr Glu Ala Cys Lys Asp Ser 35 40 45
Arg Ile Gly Gly Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu 50
55 60 Leu Thr Trp Glu Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser
Asp 65 70 75 80 Asn Glu Leu Gln Glu Met Ser Asn Gln Gly Ser Lys Tyr
Val Asn Lys 85 90 95 Glu Ile Gln Asn Ala Val Asn Gly Val Lys Gln
Ile Lys Thr Leu Ile 100 105 110 Glu Lys Thr Asn Glu Glu Arg Lys Thr
Leu Leu Ser Asn Leu Glu Glu 115 120 125 Ala Lys Lys Lys Lys Glu Asp
Ala Leu Asn Glu Thr Arg Glu Ser Glu 130 135 140 Thr Lys Leu Lys Glu
Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala 145 150 155 160 Leu Trp
Glu Glu Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe 165 170 175
Tyr Ala Arg Val Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu 180
185 190 Glu Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn
Gly 195 200 205 Asp Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln
Thr His Met 210 215 220 Leu Asp Val Met Gln Asp His Phe Ser Arg Ala
Ser Ser Ile Ile Asp 225 230 235 240 Glu Leu Phe Gln Asp Arg Phe Phe
Thr Arg Glu Pro Gln Asp Thr Tyr 245 250 255 His Tyr Leu Pro Phe Ser
Leu Pro His Arg Arg Pro His Phe Phe Phe 260 265 270 Pro Lys Ser Arg
Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu 275
280 285 Pro Leu Asn Phe His Ala Met Phe Gln Pro Phe Leu Glu Met Ile
His 290 295 300 Glu Ala Gln Gln Ala Met Asp Ile His Phe His Ser Pro
Ala Phe Gln 305 310 315 320 His Pro Pro Thr Glu Phe Ile Arg Glu Gly
Asp Asp Asp Arg Thr Val 325 330 335 Cys Arg Glu Ile Arg His Asn Ser
Thr Gly Cys Leu Arg Met Lys Asp 340 345 350 Gln Cys Asp Lys Cys Arg
Glu Ile Leu Ser Val Asp Cys Ser Thr Asn 355 360 365 Asn Pro Ser Gln
Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln 370 375 380 Val Ala
Glu Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr 385 390 395
400 Gln Trp Lys Met Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu
405 410 415 Gln Phe Asn Trp Val Ser Arg Leu Ala Asn Leu Thr Gln Gly
Glu Asp 420 425 430 Gln Tyr Tyr Leu Arg Val Thr Thr Val Ala Ser His
Thr Ser Asp Ser 435 440 445 Asp Val Pro Ser Gly Val Thr Glu Val Val
Val Lys Leu Phe Asp Ser 450 455 460 Asp Pro Ile Thr Val Thr Val Pro
Val Glu Val Ser Arg Lys Asn Pro 465 470 475 480 Lys Phe Met Glu Thr
Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys 485 490 495 Lys His Arg
Glu Glu 500 286622PRTHomo sapiens 286Met Ala His Val Arg Gly Leu
Gln Leu Pro Gly Cys Leu Ala Leu Ala 1 5 10 15 Ala Leu Cys Ser Leu
Val His Ser Gln His Val Phe Leu Ala Pro Gln 20 25 30 Gln Ala Arg
Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 35 40 45 Glu
Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 50 55
60 Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr
65 70 75 80 Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg
Thr Pro 85 90 95 Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys
Ala Glu Gly Leu 100 105 110 Gly Thr Asn Tyr Arg Gly His Val Asn Ile
Thr Arg Ser Gly Ile Glu 115 120 125 Cys Gln Leu Trp Arg Ser Arg Tyr
Pro His Lys Pro Glu Ile Asn Ser 130 135 140 Thr Thr His Pro Gly Ala
Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 145 150 155 160 Asp Ser Ser
Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 165 170 175 Arg
Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 180 185
190 Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro
195 200 205 Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln
Gly Arg 210 215 220 Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala
Trp Ala Ser Ala 225 230 235 240 Gln Ala Lys Ala Leu Ser Lys His Gln
Asp Phe Asn Ser Ala Val Gln 245 250 255 Leu Val Glu Asn Phe Cys Arg
Asn Pro Asp Gly Asp Glu Glu Gly Val 260 265 270 Trp Cys Tyr Val Ala
Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 275 280 285 Asn Tyr Cys
Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 290 295 300 Glu
Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 305 310
315 320 Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp
Cys 325 330 335 Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp
Lys Thr Glu 340 345 350 Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg
Ile Val Glu Gly Ser 355 360 365 Asp Ala Glu Ile Gly Met Ser Pro Trp
Gln Val Met Leu Phe Arg Lys 370 375 380 Ser Pro Gln Glu Leu Leu Cys
Gly Ala Ser Leu Ile Ser Asp Arg Trp 385 390 395 400 Val Leu Thr Ala
Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 405 410 415 Phe Thr
Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 420 425 430
Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 435
440 445 Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile
Ala 450 455 460 Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr
Ile His Pro 465 470 475 480 Val Cys Leu Pro Asp Arg Glu Thr Ala Ala
Ser Leu Leu Gln Ala Gly 485 490 495 Tyr Lys Gly Arg Val Thr Gly Trp
Gly Asn Leu Lys Glu Thr Trp Thr 500 505 510 Ala Asn Val Gly Lys Gly
Gln Pro Ser Val Leu Gln Val Val Asn Leu 515 520 525 Pro Ile Val Glu
Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 530 535 540 Thr Asp
Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 545 550 555
560 Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser
565 570 575 Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp
Gly Glu 580 585 590 Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr
His Val Phe Arg 595 600 605 Leu Lys Lys Trp Ile Gln Lys Val Ile Asp
Gln Phe Gly Glu 610 615 620 287488PRTHomo sapiens 287Met Gly Arg
Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 1 5 10 15 Leu
Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 20 25
30 Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe Leu Glu Glu Met
35 40 45 Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys
Ser Tyr 50 55 60 Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys
Thr Asn Glu Phe 65 70 75 80 Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys
Glu Thr Ser Pro Cys Gln 85 90 95 Asn Gln Gly Lys Cys Lys Asp Gly
Leu Gly Glu Tyr Thr Cys Thr Cys 100 105 110 Leu Glu Gly Phe Glu Gly
Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 115 120 125 Cys Ser Leu Asp
Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 130 135 140 Asn Ser
Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 145 150 155
160 Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr
165 170 175 Leu Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser
Ser Gly 180 185 190 Glu Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp
Ala Ala Asp Leu 195 200 205 Asp Pro Thr Glu Asn Pro Phe Asp Leu Leu
Asp Phe Asn Gln Thr Gln 210 215 220 Pro Glu Arg Gly Asp Asn Asn Leu
Thr Arg Ile Val Gly Gly Gln Glu 225 230 235 240 Cys Lys Asp Gly Glu
Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 245 250 255 Asn Glu Gly
Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 260 265 270 Thr
Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val 275 280
285 Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu
290 295 300 Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr
Tyr Asp 305 310 315 320 Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro
Ile Thr Phe Arg Met 325 330 335 Asn Val Ala Pro Ala Cys Leu Pro Glu
Arg Asp Trp Ala Glu Ser Thr 340 345 350 Leu Met Thr Gln Lys Thr Gly
Ile Val Ser Gly Phe Gly Arg Thr His 355 360 365 Glu Lys Gly Arg Gln
Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 370 375 380 Val Asp Arg
Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln 385 390 395 400
Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln 405
410 415 Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr
Phe 420 425 430 Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg
Lys Gly Lys 435 440 445 Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu
Lys Trp Ile Asp Arg 450 455 460 Ser Met Lys Thr Arg Gly Leu Pro Lys
Ala Lys Ser His Ala Pro Glu 465 470 475 480 Val Ile Thr Ser Ser Pro
Leu Lys 485 288500PRTHomo sapiens 288Met Ala Ser Arg Leu Thr Leu
Leu Thr Leu Leu Leu Leu Leu Leu Ala 1 5 10 15 Gly Asp Arg Ala Ser
Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 20 25 30 Asp Pro Glu
Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 35 40 45 Val
Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 50 55
60 Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala
65 70 75 80 Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro
Thr Thr 85 90 95 Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln
Leu Pro Thr Asp 100 105 110 Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe
Cys Pro Gly Pro Val Thr 115 120 125 Leu Cys Ser Asp Leu Glu Ser His
Ser Thr Glu Ala Val Leu Gly Asp 130 135 140 Ala Leu Val Asp Phe Ser
Leu Lys Leu Tyr His Ala Phe Ser Ala Met 145 150 155 160 Lys Lys Val
Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 165 170 175 Leu
Leu Thr Gln Val Leu Leu Gly Ala Gly Gln Asn Thr Lys Thr Asn 180 185
190 Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln
195 200 205 Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser
Gln Ile 210 215 220 Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe
Val Asn Ala Ser 225 230 235 240 Arg Thr Leu Tyr Ser Ser Ser Pro Arg
Val Leu Ser Asn Asn Ser Asp 245 250 255 Ala Asn Leu Glu Leu Ile Asn
Thr Trp Val Ala Lys Asn Thr Asn Asn 260 265 270 Lys Ile Ser Arg Leu
Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 275 280 285 Leu Leu Asn
Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 290 295 300 Pro
Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 305 310
315 320 Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe
Ile 325 330 335 Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu
Ser His Asn 340 345 350 Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu
Lys His Arg Leu Glu 355 360 365 Asp Met Glu Gln Ala Leu Ser Pro Ser
Val Phe Lys Ala Ile Met Glu 370 375 380 Lys Leu Glu Met Ser Lys Phe
Gln Pro Thr Leu Leu Thr Leu Pro Arg 385 390 395 400 Ile Lys Val Thr
Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 405 410 415 Glu Phe
Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 420 425 430
Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 435
440 445 Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser
Val 450 455 460 Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe
Leu Phe Val 465 470 475 480 Leu Trp Asp Gln Gln His Lys Phe Pro Val
Phe Met Gly Arg Val Tyr 485 490 495 Asp Pro Arg Ala 500
289705PRTHomo sapiens 289Met Trp Leu Leu Tyr Leu Leu Val Pro Ala
Leu Phe Cys Arg Ala Gly 1 5 10 15 Gly Ser Ile Pro Ile Pro Gln Lys
Leu Phe Gly Glu Val Thr Ser Pro 20 25 30 Leu Phe Pro Lys Pro Tyr
Pro Asn Asn Phe Glu Thr Thr Thr Val Ile 35 40 45 Thr Val Pro Thr
Gly Tyr Arg Val Lys Leu Val Phe Gln Gln Phe Asp 50 55 60 Leu Glu
Pro Ser Glu Gly Cys Phe Tyr Asp Tyr Val Lys Ile Ser Ala 65 70 75 80
Asp Lys Lys Ser Leu Gly Arg Phe Cys Gly Gln Leu Gly Ser Pro Leu 85
90 95 Gly Asn Pro Pro Gly Lys Lys Glu Phe Met Ser Gln Gly Asn Lys
Met 100 105 110 Leu Leu Thr Phe His Thr Asp Phe Ser Asn Glu Glu Asn
Gly Thr Ile 115 120 125 Met Phe Tyr Lys Gly Phe Leu Ala Tyr Tyr Gln
Ala Val Asp Leu Asp 130 135 140 Glu Cys Ala Ser Arg Ser Lys Leu Gly
Glu Glu Asp Pro Gln Pro Gln 145 150 155 160 Cys Gln His Leu Cys His
Asn Tyr Val Gly Gly Tyr Phe Cys Ser Cys 165 170 175 Arg Pro Gly Tyr
Glu Leu Gln Glu Asp Arg His Ser Cys Gln Ala Glu 180 185 190 Cys Ser
Ser Glu Leu Tyr Thr Glu Ala Ser Gly Tyr Ile Ser Ser Leu 195 200 205
Glu Tyr Pro Arg Ser Tyr Pro Pro Asp Leu Arg Cys Asn Tyr Ser Ile 210
215 220 Arg Val Glu Arg Gly Leu Thr Leu His Leu Lys Phe Leu Glu Pro
Phe 225 230 235 240 Asp Ile Asp Asp His Gln Gln Val His Cys Pro Tyr
Asp Gln Leu Gln 245 250 255 Ile Tyr Ala Asn Gly Lys Asn Ile Gly Glu
Phe Cys Gly Lys Gln Arg 260 265 270 Pro Pro Asp Leu Asp Thr Ser Ser
Asn Ala Val Asp Leu Leu Phe Phe 275 280 285 Thr Asp Glu Ser Gly Asp
Ser Arg Gly Trp Lys Leu Arg Tyr Thr Thr 290 295 300 Glu Ile Ile Lys
Cys Pro Gln Pro Lys Thr Leu Asp Glu Phe Thr Ile 305 310 315 320 Ile
Gln Asn Leu Gln Pro Gln Tyr Gln Phe Arg Asp Tyr Phe Ile Ala 325 330
335 Thr Cys Lys Gln Gly Tyr Gln Leu Ile Glu Gly Asn Gln Val Leu His
340 345 350 Ser Phe Thr Ala Val Cys Gln Asp Asp Gly Thr Trp His Arg
Ala Met 355 360 365 Pro Arg Cys Lys Ile Lys Asp Cys Gly Gln Pro Arg
Asn Leu Pro Asn 370 375 380 Gly Asp Phe Arg Tyr Thr Thr Thr Met Gly
Val Asn Thr Tyr Lys Ala 385 390 395 400 Arg Ile Gln Tyr Tyr Cys His
Glu Pro Tyr Tyr Lys Met Gln Thr Arg 405 410 415 Ala Gly Ser Arg Glu
Ser Glu Gln Gly Val Tyr Thr Cys Thr Ala Gln 420 425 430 Gly Ile Trp
Lys Asn Glu Gln Lys Gly Glu Lys Ile Pro Arg Cys Leu 435 440 445 Pro
Val Cys Gly Lys Pro Val Asn Pro Val Glu Gln Arg Gln Arg Ile 450 455
460 Ile Gly Gly Gln Lys
Ala Lys Met Gly Asn Phe Pro Trp Gln Val Phe 465 470 475 480 Thr Asn
Ile His Gly Arg Gly Gly Gly Ala Leu Leu Gly Asp Arg Trp 485 490 495
Ile Leu Thr Ala Ala His Thr Leu Tyr Pro Lys Glu His Glu Ala Gln 500
505 510 Ser Asn Ala Ser Leu Asp Val Phe Leu Gly His Thr Asn Val Glu
Glu 515 520 525 Leu Met Lys Leu Gly Asn His Pro Ile Arg Arg Val Ser
Val His Pro 530 535 540 Asp Tyr Arg Gln Asp Glu Ser Tyr Asn Phe Glu
Gly Asp Ile Ala Leu 545 550 555 560 Leu Glu Leu Glu Asn Ser Val Thr
Leu Gly Pro Asn Leu Leu Pro Ile 565 570 575 Cys Leu Pro Asp Asn Asp
Thr Phe Tyr Asp Leu Gly Leu Met Gly Tyr 580 585 590 Val Ser Gly Phe
Gly Val Met Glu Glu Lys Ile Ala His Asp Leu Arg 595 600 605 Phe Val
Arg Leu Pro Val Ala Asn Pro Gln Ala Cys Glu Asn Trp Leu 610 615 620
Arg Gly Lys Asn Arg Met Asp Val Phe Ser Gln Asn Met Phe Cys Ala 625
630 635 640 Gly His Pro Ser Leu Lys Gln Asp Ala Cys Gln Gly Asp Ser
Gly Gly 645 650 655 Val Phe Ala Val Arg Asp Pro Asn Thr Asp Arg Trp
Val Ala Thr Gly 660 665 670 Ile Val Ser Trp Gly Ile Gly Cys Ser Arg
Gly Tyr Gly Phe Tyr Thr 675 680 685 Lys Val Leu Asn Tyr Val Asp Trp
Ile Lys Lys Glu Met Glu Glu Glu 690 695 700 Asp 705 290487PRTHomo
sapiens 290Met Pro Gly Pro Arg Val Trp Gly Lys Tyr Leu Trp Arg Ser
Pro His 1 5 10 15 Ser Lys Gly Cys Pro Gly Ala Met Trp Trp Leu Leu
Leu Trp Gly Val 20 25 30 Leu Gln Ala Cys Pro Thr Arg Gly Ser Val
Leu Leu Ala Gln Glu Leu 35 40 45 Pro Gln Gln Leu Thr Ser Pro Gly
Tyr Pro Glu Pro Tyr Gly Lys Gly 50 55 60 Gln Glu Ser Ser Thr Asp
Ile Lys Ala Pro Glu Gly Phe Ala Val Arg 65 70 75 80 Leu Val Phe Gln
Asp Phe Asp Leu Glu Pro Ser Gln Asp Cys Ala Gly 85 90 95 Asp Ser
Val Thr Ile Ser Phe Val Gly Ser Asp Pro Ser Gln Phe Cys 100 105 110
Gly Gln Gln Gly Ser Pro Leu Gly Arg Pro Pro Gly Gln Arg Glu Phe 115
120 125 Val Ser Ser Gly Arg Ser Leu Arg Leu Thr Phe Arg Thr Gln Pro
Ser 130 135 140 Ser Glu Asn Lys Thr Ala His Leu His Lys Gly Phe Leu
Ala Leu Tyr 145 150 155 160 Gln Thr Val Ala Val Asn Tyr Ser Gln Pro
Ile Ser Glu Ala Ser Arg 165 170 175 Gly Ser Glu Ala Ile Asn Ala Pro
Gly Asp Asn Pro Ala Lys Val Gln 180 185 190 Asn His Cys Gln Glu Pro
Tyr Tyr Gln Ala Ala Ala Ala Gly Ala Leu 195 200 205 Thr Cys Ala Thr
Pro Gly Thr Trp Lys Asp Arg Gln Asp Gly Glu Glu 210 215 220 Val Leu
Gln Cys Met Pro Val Cys Gly Arg Pro Val Thr Pro Ile Ala 225 230 235
240 Gln Asn Gln Thr Thr Leu Gly Ser Ser Arg Ala Lys Leu Gly Asn Phe
245 250 255 Pro Trp Gln Ala Phe Thr Ser Ile His Gly Arg Gly Gly Gly
Ala Leu 260 265 270 Leu Gly Asp Arg Trp Ile Leu Thr Ala Ala His Thr
Val Tyr Pro Lys 275 280 285 Asp Ser Val Ser Leu Arg Lys Asn Gln Ser
Val Asn Val Phe Leu Gly 290 295 300 His Thr Ala Ile Asp Glu Met Leu
Lys Leu Gly Asn His Pro Val His 305 310 315 320 Arg Val Val Val His
Pro Asp Tyr Arg Gln Asn Glu Ser His Asn Phe 325 330 335 Ser Gly Asp
Ile Ala Leu Leu Glu Leu Gln His Ser Ile Pro Leu Gly 340 345 350 Pro
Asn Val Leu Pro Val Cys Leu Pro Asp Asn Glu Thr Leu Tyr Arg 355 360
365 Ser Gly Leu Leu Gly Tyr Val Ser Gly Phe Gly Met Glu Met Gly Trp
370 375 380 Leu Thr Thr Glu Leu Lys Tyr Ser Arg Leu Pro Val Ala Pro
Arg Glu 385 390 395 400 Ala Cys Asn Ala Trp Leu Gln Lys Arg Gln Arg
Pro Glu Val Phe Ser 405 410 415 Asp Asn Met Phe Cys Val Gly Asp Glu
Thr Gln Arg His Ser Val Cys 420 425 430 Gln Gly Asp Ser Gly Ser Val
Tyr Val Val Trp Asp Asn His Ala His 435 440 445 His Trp Val Ala Thr
Gly Ile Val Ser Trp Gly Ile Gly Cys Gly Glu 450 455 460 Gly Tyr Asp
Phe Tyr Thr Lys Val Leu Ser Tyr Val Asp Trp Ile Lys 465 470 475 480
Gly Val Met Asn Gly Lys Asn 485 291688PRTHomo sapiens 291Met Trp
Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala Glu 1 5 10 15
Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala Tyr 20
25 30 Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly
Tyr 35 40 45 Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu
Ser Glu Asn 50 55 60 Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly
Asp Thr Glu Glu Gly 65 70 75 80 Arg Leu Cys Gly Gln Arg Ser Ser Asn
Asn Pro His Ser Pro Ile Val 85 90 95 Glu Glu Phe Gln Val Pro Tyr
Asn Lys Leu Gln Val Ile Phe Lys Ser 100 105 110 Asp Phe Ser Asn Glu
Glu Arg Phe Thr Gly Phe Ala Ala Tyr Tyr Val 115 120 125 Ala Thr Asp
Ile Asn Glu Cys Thr Asp Phe Val Asp Val Pro Cys Ser 130 135 140 His
Phe Cys Asn Asn Phe Ile Gly Gly Tyr Phe Cys Ser Cys Pro Pro 145 150
155 160 Glu Tyr Phe Leu His Asp Asp Met Lys Asn Cys Gly Val Asn Cys
Ser 165 170 175 Gly Asp Val Phe Thr Ala Leu Ile Gly Glu Ile Ala Ser
Pro Asn Tyr 180 185 190 Pro Lys Pro Tyr Pro Glu Asn Ser Arg Cys Glu
Tyr Gln Ile Arg Leu 195 200 205 Glu Lys Gly Phe Gln Val Val Val Thr
Leu Arg Arg Glu Asp Phe Asp 210 215 220 Val Glu Ala Ala Asp Ser Ala
Gly Asn Cys Leu Asp Ser Leu Val Phe 225 230 235 240 Val Ala Gly Asp
Arg Gln Phe Gly Pro Tyr Cys Gly His Gly Phe Pro 245 250 255 Gly Pro
Leu Asn Ile Glu Thr Lys Ser Asn Ala Leu Asp Ile Ile Phe 260 265 270
Gln Thr Asp Leu Thr Gly Gln Lys Lys Gly Trp Lys Leu Arg Tyr His 275
280 285 Gly Asp Pro Met Pro Cys Pro Lys Glu Asp Thr Pro Asn Ser Val
Trp 290 295 300 Glu Pro Ala Lys Ala Lys Tyr Val Phe Arg Asp Val Val
Gln Ile Thr 305 310 315 320 Cys Leu Asp Gly Phe Glu Val Val Glu Gly
Arg Val Gly Ala Thr Ser 325 330 335 Phe Tyr Ser Thr Cys Gln Ser Asn
Gly Lys Trp Ser Asn Ser Lys Leu 340 345 350 Lys Cys Gln Pro Val Asp
Cys Gly Ile Pro Glu Ser Ile Glu Asn Gly 355 360 365 Lys Val Glu Asp
Pro Glu Ser Thr Leu Phe Gly Ser Val Ile Arg Tyr 370 375 380 Thr Cys
Glu Glu Pro Tyr Tyr Tyr Met Glu Asn Gly Gly Gly Gly Glu 385 390 395
400 Tyr His Cys Ala Gly Asn Gly Ser Trp Val Asn Glu Val Leu Gly Pro
405 410 415 Glu Leu Pro Lys Cys Val Pro Val Cys Gly Val Pro Arg Glu
Pro Phe 420 425 430 Glu Glu Lys Gln Arg Ile Ile Gly Gly Ser Asp Ala
Asp Ile Lys Asn 435 440 445 Phe Pro Trp Gln Val Phe Phe Asp Asn Pro
Trp Ala Gly Gly Ala Leu 450 455 460 Ile Asn Glu Tyr Trp Val Leu Thr
Ala Ala His Val Val Glu Gly Asn 465 470 475 480 Arg Glu Pro Thr Met
Tyr Val Gly Ser Thr Ser Val Gln Thr Ser Arg 485 490 495 Leu Ala Lys
Ser Lys Met Leu Thr Pro Glu His Val Phe Ile His Pro 500 505 510 Gly
Trp Lys Leu Leu Glu Val Pro Glu Gly Arg Thr Asn Phe Asp Asn 515 520
525 Asp Ile Ala Leu Val Arg Leu Lys Asp Pro Val Lys Met Gly Pro Thr
530 535 540 Val Ser Pro Ile Cys Leu Pro Gly Thr Ser Ser Asp Tyr Asn
Leu Met 545 550 555 560 Asp Gly Asp Leu Gly Leu Ile Ser Gly Trp Gly
Arg Thr Glu Lys Arg 565 570 575 Asp Arg Ala Val Arg Leu Lys Ala Ala
Arg Leu Pro Val Ala Pro Leu 580 585 590 Arg Lys Cys Lys Glu Val Lys
Val Glu Lys Pro Thr Ala Asp Ala Glu 595 600 605 Ala Tyr Val Phe Thr
Pro Asn Met Ile Cys Ala Gly Gly Glu Lys Gly 610 615 620 Met Asp Ser
Cys Lys Gly Asp Ser Gly Gly Ala Phe Ala Val Gln Asp 625 630 635 640
Pro Asn Asp Lys Thr Lys Phe Tyr Ala Ala Gly Leu Val Ser Trp Gly 645
650 655 Pro Gln Cys Gly Thr Tyr Gly Leu Tyr Thr Arg Val Lys Asn Tyr
Val 660 665 670 Asp Trp Ile Met Lys Thr Met Gln Glu Asn Ser Thr Pro
Arg Glu Asp 675 680 685 292752PRTHomo sapiens 292Met Gly Pro Leu
Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 1 5 10 15 Leu Ala
Asp Ser Ala Pro Ser Cys Pro Gln Asn Val Asn Ile Ser Gly 20 25 30
Gly Thr Phe Thr Leu Ser His Gly Trp Ala Pro Gly Ser Leu Leu Thr 35
40 45 Tyr Ser Cys Pro Gln Gly Leu Tyr Pro Ser Pro Ala Ser Arg Leu
Cys 50 55 60 Lys Ser Ser Gly Gln Trp Gln Thr Pro Gly Ala Thr Arg
Ser Leu Ser 65 70 75 80 Lys Ala Val Cys Lys Pro Val Arg Cys Pro Ala
Pro Val Ser Phe Glu 85 90 95 Asn Gly Ile Tyr Thr Pro Arg Leu Gly
Ser Tyr Pro Val Gly Gly Asn 100 105 110 Val Ser Phe Glu Cys Glu Asp
Gly Phe Ile Leu Arg Gly Ser Pro Val 115 120 125 Arg Gln Cys Arg Pro
Asn Gly Met Trp Asp Gly Glu Thr Ala Val Cys 130 135 140 Asp Asn Gly
Ala Gly His Cys Pro Asn Pro Gly Ile Ser Leu Gly Ala 145 150 155 160
Val Arg Thr Gly Phe Arg Phe Gly His Gly Asp Lys Val Arg Tyr Arg 165
170 175 Cys Ser Ser Asn Leu Val Leu Thr Gly Ser Ser Glu Arg Glu Cys
Gln 180 185 190 Gly Asn Gly Val Trp Ser Gly Thr Glu Pro Ile Cys Arg
Gln Pro Tyr 195 200 205 Ser Tyr Asp Phe Pro Glu Asp Val Ala Pro Ala
Leu Gly Thr Ser Phe 210 215 220 Ser His Met Leu Gly Ala Thr Asn Pro
Thr Gln Lys Thr Lys Glu Ser 225 230 235 240 Leu Gly Arg Lys Ile Gln
Ile Gln Arg Ser Gly His Leu Asn Leu Tyr 245 250 255 Leu Leu Leu Asp
Cys Ser Gln Ser Val Ser Glu Asn Asp Phe Leu Ile 260 265 270 Phe Lys
Glu Ser Ala Ser Leu Met Val Asp Arg Ile Phe Ser Phe Glu 275 280 285
Ile Asn Val Ser Val Ala Ile Ile Thr Phe Ala Ser Glu Pro Lys Val 290
295 300 Leu Met Ser Val Leu Asn Asp Asn Ser Arg Asp Met Thr Glu Val
Ile 305 310 315 320 Ser Ser Leu Glu Asn Ala Asn Tyr Lys Asp His Glu
Asn Gly Thr Gly 325 330 335 Thr Asn Thr Tyr Ala Ala Leu Asn Ser Val
Tyr Leu Met Met Asn Asn 340 345 350 Gln Met Arg Leu Leu Gly Met Glu
Thr Met Ala Trp Gln Glu Ile Arg 355 360 365 His Ala Ile Ile Leu Leu
Thr Asp Gly Lys Ser Asn Met Gly Gly Ser 370 375 380 Pro Lys Thr Ala
Val Asp His Ile Arg Glu Ile Leu Asn Ile Asn Gln 385 390 395 400 Lys
Arg Asn Asp Tyr Leu Asp Ile Tyr Ala Ile Gly Val Gly Lys Leu 405 410
415 Asp Val Asp Trp Arg Glu Leu Asn Glu Leu Gly Ser Lys Lys Asp Gly
420 425 430 Glu Arg His Ala Phe Ile Leu Gln Asp Thr Lys Ala Leu His
Gln Val 435 440 445 Phe Glu His Met Leu Asp Val Ser Lys Leu Thr Asp
Thr Ile Cys Gly 450 455 460 Val Gly Asn Met Ser Ala Asn Ala Ser Asp
Gln Glu Arg Thr Pro Trp 465 470 475 480 His Val Thr Ile Lys Pro Lys
Ser Gln Glu Thr Cys Arg Gly Ala Leu 485 490 495 Ile Ser Asp Gln Trp
Val Leu Thr Ala Ala His Cys Phe Arg Asp Gly 500 505 510 Asn Asp His
Ser Leu Trp Arg Val Asn Val Gly Asp Pro Lys Ser Gln 515 520 525 Trp
Gly Lys Glu Phe Leu Ile Glu Lys Ala Val Ile Ser Pro Gly Phe 530 535
540 Asp Val Phe Ala Lys Lys Asn Gln Gly Ile Leu Glu Phe Tyr Gly Asp
545 550 555 560 Asp Ile Ala Leu Leu Lys Leu Ala Gln Lys Val Lys Met
Ser Thr His 565 570 575 Ala Arg Pro Ile Cys Leu Pro Cys Thr Met Glu
Ala Asn Leu Ala Leu 580 585 590 Arg Arg Pro Gln Gly Ser Thr Cys Arg
Asp His Glu Asn Glu Leu Leu 595 600 605 Asn Lys Gln Ser Val Pro Ala
His Phe Val Ala Leu Asn Gly Ser Lys 610 615 620 Leu Asn Ile Asn Leu
Lys Met Gly Val Glu Trp Thr Ser Cys Ala Glu 625 630 635 640 Val Val
Ser Gln Glu Lys Thr Met Phe Pro Asn Leu Thr Asp Val Arg 645 650 655
Glu Val Val Thr Asp Gln Phe Leu Cys Ser Gly Thr Gln Glu Asp Glu 660
665 670 Ser Pro Cys Lys Gly Glu Ser Gly Gly Ala Val Phe Leu Glu Arg
Arg 675 680 685 Phe Arg Phe Phe Gln Val Gly Leu Val Ser Trp Gly Leu
Tyr Asn Pro 690 695 700 Cys Leu Gly Ser Ala Asp Lys Asn Ser Arg Lys
Arg Ala Pro Arg Ser 705 710 715 720 Lys Val Pro Pro Pro Arg Asp Phe
His Ile Asn Leu Phe Arg Met Gln 725 730 735 Pro Trp Leu Arg Gln His
Leu Gly Asp Val Leu Asn Phe Leu Pro Leu 740 745 750 2931663PRTHomo
sapiens 293Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu
Thr His 1 5 10 15 Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile
Ile Thr Pro Asn 20 25 30 Ile Leu Arg Leu Glu Ser Glu Glu Thr Met
Val Leu Glu Ala His Asp 35 40 45 Ala Gln Gly Asp Val Pro Val Thr
Val Thr Val His Asp Phe Pro Gly 50 55 60 Lys Lys Leu Val Leu Ser
Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 65 70 75 80 Asn His Met Gly
Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 85 90 95 Lys Ser
Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 100 105 110
Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 115
120 125 Tyr
Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 130 135
140 Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly
145 150 155 160 Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile
Pro Val Lys 165 170 175 Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly
Val Leu Pro Leu Ser 180 185 190 Trp Asp Ile Pro Glu Leu Val Asn Met
Gly Gln Trp Lys Ile Arg Ala 195 200 205 Tyr Tyr Glu Asn Ser Pro Gln
Gln Val Phe Ser Thr Glu Phe Glu Val 210 215 220 Lys Glu Tyr Val Leu
Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 225 230 235 240 Lys Phe
Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 245 250 255
Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 260
265 270 Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser
Leu 275 280 285 Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val
Leu Ser Arg 290 295 300 Lys Val Leu Leu Asp Gly Val Gln Asn Leu Arg
Ala Glu Asp Leu Val 305 310 315 320 Gly Lys Ser Leu Tyr Val Ser Ala
Thr Val Ile Leu His Ser Gly Ser 325 330 335 Asp Met Val Gln Ala Glu
Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 340 345 350 Tyr Gln Ile His
Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 355 360 365 Pro Phe
Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 370 375 380
Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 385
390 395 400 Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His
Pro Ser 405 410 415 Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys
Gln Glu Leu Ser 420 425 430 Glu Ala Glu Gln Ala Thr Arg Thr Met Gln
Ala Leu Pro Tyr Ser Thr 435 440 445 Val Gly Asn Ser Asn Asn Tyr Leu
His Leu Ser Val Leu Arg Thr Glu 450 455 460 Leu Arg Pro Gly Glu Thr
Leu Asn Val Asn Phe Leu Leu Arg Met Asp 465 470 475 480 Arg Ala His
Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 485 490 495 Lys
Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 500 505
510 Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser
515 520 525 Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly
Gln Arg 530 535 540 Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys
Asp Ser Cys Val 545 550 555 560 Gly Ser Leu Val Val Lys Ser Gly Gln
Ser Glu Asp Arg Gln Pro Val 565 570 575 Pro Gly Gln Gln Met Thr Leu
Lys Ile Glu Gly Asp His Gly Ala Arg 580 585 590 Val Val Leu Val Ala
Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 595 600 605 Asn Lys Leu
Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 610 615 620 Ile
Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 625 630
635 640 Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala
Gln 645 650 655 Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg
Arg Arg Ser 660 665 670 Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val
Gly Lys Tyr Pro Lys 675 680 685 Glu Leu Arg Lys Cys Cys Glu Asp Gly
Met Arg Glu Asn Pro Met Arg 690 695 700 Phe Ser Cys Gln Arg Arg Thr
Arg Phe Ile Ser Leu Gly Glu Ala Cys 705 710 715 720 Lys Lys Val Phe
Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 725 730 735 Gln His
Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 740 745 750
Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 755
760 765 Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys
Asn 770 775 780 Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp
Ser Ile Thr 785 790 795 800 Thr Trp Glu Ile Leu Ala Val Ser Met Ser
Asp Lys Lys Gly Ile Cys 805 810 815 Val Ala Asp Pro Phe Glu Val Thr
Val Met Gln Asp Phe Phe Ile Asp 820 825 830 Leu Arg Leu Pro Tyr Ser
Val Val Arg Asn Glu Gln Val Glu Ile Arg 835 840 845 Ala Val Leu Tyr
Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 850 855 860 Glu Leu
Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 865 870 875
880 Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val
885 890 895 Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val
Glu Val 900 905 910 Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly
Val Arg Lys Ser 915 920 925 Leu Lys Val Val Pro Glu Gly Ile Arg Met
Asn Lys Thr Val Ala Val 930 935 940 Arg Thr Leu Asp Pro Glu Arg Leu
Gly Arg Glu Gly Val Gln Lys Glu 945 950 955 960 Asp Ile Pro Pro Ala
Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 965 970 975 Glu Thr Arg
Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 980 985 990 Asp
Ala Val Asp Ala Glu Arg Leu Lys His Leu Ile Val Thr Pro Ser 995
1000 1005 Gly Cys Gly Glu Gln Asn Met Ile Gly Met Thr Pro Thr Val
Ile 1010 1015 1020 Ala Val His Tyr Leu Asp Glu Thr Glu Gln Trp Glu
Lys Phe Gly 1025 1030 1035 Leu Glu Lys Arg Gln Gly Ala Leu Glu Leu
Ile Lys Lys Gly Tyr 1040 1045 1050 Thr Gln Gln Leu Ala Phe Arg Gln
Pro Ser Ser Ala Phe Ala Ala 1055 1060 1065 Phe Val Lys Arg Ala Pro
Ser Thr Trp Leu Thr Ala Tyr Val Val 1070 1075 1080 Lys Val Phe Ser
Leu Ala Val Asn Leu Ile Ala Ile Asp Ser Gln 1085 1090 1095 Val Leu
Cys Gly Ala Val Lys Trp Leu Ile Leu Glu Lys Gln Lys 1100 1105 1110
Pro Asp Gly Val Phe Gln Glu Asp Ala Pro Val Ile His Gln Glu 1115
1120 1125 Met Ile Gly Gly Leu Arg Asn Asn Asn Glu Lys Asp Met Ala
Leu 1130 1135 1140 Thr Ala Phe Val Leu Ile Ser Leu Gln Glu Ala Lys
Asp Ile Cys 1145 1150 1155 Glu Glu Gln Val Asn Ser Leu Pro Gly Ser
Ile Thr Lys Ala Gly 1160 1165 1170 Asp Phe Leu Glu Ala Asn Tyr Met
Asn Leu Gln Arg Ser Tyr Thr 1175 1180 1185 Val Ala Ile Ala Gly Tyr
Ala Leu Ala Gln Met Gly Arg Leu Lys 1190 1195 1200 Gly Pro Leu Leu
Asn Lys Phe Leu Thr Thr Ala Lys Asp Lys Asn 1205 1210 1215 Arg Trp
Glu Asp Pro Gly Lys Gln Leu Tyr Asn Val Glu Ala Thr 1220 1225 1230
Ser Tyr Ala Leu Leu Ala Leu Leu Gln Leu Lys Asp Phe Asp Phe 1235
1240 1245 Val Pro Pro Val Val Arg Trp Leu Asn Glu Gln Arg Tyr Tyr
Gly 1250 1255 1260 Gly Gly Tyr Gly Ser Thr Gln Ala Thr Phe Met Val
Phe Gln Ala 1265 1270 1275 Leu Ala Gln Tyr Gln Lys Asp Ala Pro Asp
His Gln Glu Leu Asn 1280 1285 1290 Leu Asp Val Ser Leu Gln Leu Pro
Ser Arg Ser Ser Lys Ile Thr 1295 1300 1305 His Arg Ile His Trp Glu
Ser Ala Ser Leu Leu Arg Ser Glu Glu 1310 1315 1320 Thr Lys Glu Asn
Glu Gly Phe Thr Val Thr Ala Glu Gly Lys Gly 1325 1330 1335 Gln Gly
Thr Leu Ser Val Val Thr Met Tyr His Ala Lys Ala Lys 1340 1345 1350
Asp Gln Leu Thr Cys Asn Lys Phe Asp Leu Lys Val Thr Ile Lys 1355
1360 1365 Pro Ala Pro Glu Thr Glu Lys Arg Pro Gln Asp Ala Lys Asn
Thr 1370 1375 1380 Met Ile Leu Glu Ile Cys Thr Arg Tyr Arg Gly Asp
Gln Asp Ala 1385 1390 1395 Thr Met Ser Ile Leu Asp Ile Ser Met Met
Thr Gly Phe Ala Pro 1400 1405 1410 Asp Thr Asp Asp Leu Lys Gln Leu
Ala Asn Gly Val Asp Arg Tyr 1415 1420 1425 Ile Ser Lys Tyr Glu Leu
Asp Lys Ala Phe Ser Asp Arg Asn Thr 1430 1435 1440 Leu Ile Ile Tyr
Leu Asp Lys Val Ser His Ser Glu Asp Asp Cys 1445 1450 1455 Leu Ala
Phe Lys Val His Gln Tyr Phe Asn Val Glu Leu Ile Gln 1460 1465 1470
Pro Gly Ala Val Lys Val Tyr Ala Tyr Tyr Asn Leu Glu Glu Ser 1475
1480 1485 Cys Thr Arg Phe Tyr His Pro Glu Lys Glu Asp Gly Lys Leu
Asn 1490 1495 1500 Lys Leu Cys Arg Asp Glu Leu Cys Arg Cys Ala Glu
Glu Asn Cys 1505 1510 1515 Phe Ile Gln Lys Ser Asp Asp Lys Val Thr
Leu Glu Glu Arg Leu 1520 1525 1530 Asp Lys Ala Cys Glu Pro Gly Val
Asp Tyr Val Tyr Lys Thr Arg 1535 1540 1545 Leu Val Lys Val Gln Leu
Ser Asn Asp Phe Asp Glu Tyr Ile Met 1550 1555 1560 Ala Ile Glu Gln
Thr Ile Lys Ser Gly Ser Asp Glu Val Gln Val 1565 1570 1575 Gly Gln
Gln Arg Thr Phe Ile Ser Pro Ile Lys Cys Arg Glu Ala 1580 1585 1590
Leu Lys Leu Glu Glu Lys Lys His Tyr Leu Met Trp Gly Leu Ser 1595
1600 1605 Ser Asp Phe Trp Gly Glu Lys Pro Asn Leu Ser Tyr Ile Ile
Gly 1610 1615 1620 Lys Asp Thr Trp Val Glu His Trp Pro Glu Glu Asp
Glu Cys Gln 1625 1630 1635 Asp Glu Glu Asn Gln Lys Gln Cys Gln Asp
Leu Gly Ala Phe Thr 1640 1645 1650 Glu Ser Met Val Val Phe Gly Cys
Pro Asn 1655 1660 294597PRTHomo sapiens 294Met His Pro Pro Lys Thr
Pro Ser Gly Ala Leu His Arg Lys Arg Lys 1 5 10 15 Met Ala Ala Trp
Pro Phe Ser Arg Leu Trp Lys Val Ser Asp Pro Ile 20 25 30 Leu Phe
Gln Met Thr Leu Ile Ala Ala Leu Leu Pro Ala Val Leu Gly 35 40 45
Asn Cys Gly Pro Pro Pro Thr Leu Ser Phe Ala Ala Pro Met Asp Ile 50
55 60 Thr Leu Thr Glu Thr Arg Phe Lys Thr Gly Thr Thr Leu Lys Tyr
Thr 65 70 75 80 Cys Leu Pro Gly Tyr Val Arg Ser His Ser Thr Gln Thr
Leu Thr Cys 85 90 95 Asn Ser Asp Gly Glu Trp Val Tyr Asn Thr Phe
Cys Ile Tyr Lys Arg 100 105 110 Cys Arg His Pro Gly Glu Leu Arg Asn
Gly Gln Val Glu Ile Lys Thr 115 120 125 Asp Leu Ser Phe Gly Ser Gln
Ile Glu Phe Ser Cys Ser Glu Gly Phe 130 135 140 Phe Leu Ile Gly Ser
Thr Thr Ser Arg Cys Glu Val Gln Asp Arg Gly 145 150 155 160 Val Gly
Trp Ser His Pro Leu Pro Gln Cys Glu Ile Val Lys Cys Lys 165 170 175
Pro Pro Pro Asp Ile Arg Asn Gly Arg His Ser Gly Glu Glu Asn Phe 180
185 190 Tyr Ala Tyr Gly Phe Ser Val Thr Tyr Ser Cys Asp Pro Arg Phe
Ser 195 200 205 Leu Leu Gly His Ala Ser Ile Ser Cys Thr Val Glu Asn
Glu Thr Ile 210 215 220 Gly Val Trp Arg Pro Ser Pro Pro Thr Cys Glu
Lys Ile Thr Cys Arg 225 230 235 240 Lys Pro Asp Val Ser His Gly Glu
Met Val Ser Gly Phe Gly Pro Ile 245 250 255 Tyr Asn Tyr Lys Asp Thr
Ile Val Phe Lys Cys Gln Lys Gly Phe Val 260 265 270 Leu Arg Gly Ser
Ser Val Ile His Cys Asp Ala Asp Ser Lys Trp Asn 275 280 285 Pro Ser
Pro Pro Ala Cys Glu Pro Asn Ser Cys Ile Asn Leu Pro Asp 290 295 300
Ile Pro His Ala Ser Trp Glu Thr Tyr Pro Arg Pro Thr Lys Glu Asp 305
310 315 320 Val Tyr Val Val Gly Thr Val Leu Arg Tyr Arg Cys His Pro
Gly Tyr 325 330 335 Lys Pro Thr Thr Asp Glu Pro Thr Thr Val Ile Cys
Gln Lys Asn Leu 340 345 350 Arg Trp Thr Pro Tyr Gln Gly Cys Glu Ala
Leu Cys Cys Pro Glu Pro 355 360 365 Lys Leu Asn Asn Gly Glu Ile Thr
Gln His Arg Lys Ser Arg Pro Ala 370 375 380 Asn His Cys Val Tyr Phe
Tyr Gly Asp Glu Ile Ser Phe Ser Cys His 385 390 395 400 Glu Thr Ser
Arg Phe Ser Ala Ile Cys Gln Gly Asp Gly Thr Trp Ser 405 410 415 Pro
Arg Thr Pro Ser Cys Gly Asp Ile Cys Asn Phe Pro Pro Lys Ile 420 425
430 Ala His Gly His Tyr Lys Gln Ser Ser Ser Tyr Ser Phe Phe Lys Glu
435 440 445 Glu Ile Ile Tyr Glu Cys Asp Lys Gly Tyr Ile Leu Val Gly
Gln Ala 450 455 460 Lys Leu Ser Cys Ser Tyr Ser His Trp Ser Ala Pro
Ala Pro Gln Cys 465 470 475 480 Lys Ala Leu Cys Arg Lys Pro Glu Leu
Val Asn Gly Arg Leu Ser Val 485 490 495 Asp Lys Asp Gln Tyr Val Glu
Pro Glu Asn Val Thr Ile Gln Cys Asp 500 505 510 Ser Gly Tyr Gly Val
Val Gly Pro Gln Ser Ile Thr Cys Ser Gly Asn 515 520 525 Arg Thr Trp
Tyr Pro Glu Val Pro Lys Cys Glu Trp Glu Thr Pro Glu 530 535 540 Gly
Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro 545 550
555 560 Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser
Leu 565 570 575 Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg
Gln Ser Thr 580 585 590 Leu Asp Lys Glu Leu 595 2951744PRTHomo
sapiens 295Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe
Thr Leu 1 5 10 15 Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro
Ser Val Val His 20 25 30 Leu Gly Val Pro Leu Ser Val Gly Val Gln
Leu Gln Asp Val Pro Arg 35 40 45 Gly Gln Val Val Lys Gly Ser Val
Phe Leu Arg Asn Pro Ser Arg Asn 50 55 60 Asn Val Pro Cys Ser Pro
Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 65 70 75 80 Asp Phe Ala Leu
Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 85 90 95 Cys Gly
Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 100 105 110
His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 115
120 125 Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe
Leu Gln 130 135 140 Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val
Arg Tyr Arg Val 145 150 155 160 Phe Ala Leu Asp Gln Lys Met Arg Pro
Ser Thr Asp Thr Ile Thr Val 165 170 175 Met Val Glu Asn Ser His Gly
Leu Arg Val Arg Lys Lys Glu Val Tyr 180 185 190 Met Pro Ser Ser Ile
Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 195 200 205 Glu Pro Gly
Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 210 215 220 Ser
Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 225 230
235 240 Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val
Pro 245 250 255 Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg
Tyr Ile Tyr 260 265 270 Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg
Phe Gly Leu Leu Asp 275 280 285 Glu Asp Gly Lys Lys Thr Phe Phe Arg
Gly Leu Glu Ser Gln Thr Lys 290 295 300 Leu Val Asn Gly Gln Ser His
Ile Ser Leu Ser Lys Ala Glu Phe Gln 305 310 315 320 Asp Ala Leu Glu
Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 325 330 335 Arg Leu
Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 340 345 350
Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 355
360 365 Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro
Phe 370 375 380 Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro
Ala Ser Gly 385 390 395 400 Ile Pro Val Lys Val Ser Ala Thr Val Ser
Ser Pro Gly Ser Val Pro 405 410 415 Glu Val Gln Asp Ile Gln Gln Asn
Thr Asp Gly Ser Gly Gln Val Ser 420 425 430 Ile Pro Ile Ile Ile Pro
Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 435 440 445 Ser Ala Gly Ser
Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 450 455 460 Pro Pro
Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 465 470 475
480 Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val
485 490 495 Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu
Ser Arg 500 505 510 Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg
Thr Leu Thr Ser 515 520 525 Val Ser Val Phe Val Asp His His Leu Ala
Pro Ser Phe Tyr Phe Val 530 535 540 Ala Phe Tyr Tyr His Gly Asp His
Pro Val Ala Asn Ser Leu Arg Val 545 550 555 560 Asp Val Gln Ala Gly
Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 565 570 575 Gly Ala Lys
Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 580 585 590 Thr
Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 595 600
605 Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val
610 615 620 Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly
Gly Gly 625 630 635 640 Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly
Leu Ala Phe Ser Asp 645 650 655 Gly Asp Gln Trp Thr Leu Ser Arg Lys
Arg Leu Ser Cys Pro Lys Glu 660 665 670 Lys Thr Thr Arg Lys Lys Arg
Asn Val Asn Phe Gln Lys Ala Ile Asn 675 680 685 Glu Lys Leu Gly Gln
Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 690 695 700 Asp Gly Val
Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 705 710 715 720
Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 725
730 735 Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln
Ala 740 745 750 Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp
Leu Ile Asp 755 760 765 Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro
Glu Asn Trp Leu Trp 770 775 780 Arg Val Glu Thr Val Asp Arg Phe Gln
Ile Leu Thr Leu Trp Leu Pro 785 790 795 800 Asp Ser Leu Thr Thr Trp
Glu Ile His Gly Leu Ser Leu Ser Lys Thr 805 810 815 Lys Gly Leu Cys
Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 820 825 830 Phe His
Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 835 840 845
Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 850
855 860 Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly
Gly 865 870 875 880 Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly
Ser Ala Arg Pro 885 890 895 Val Ala Phe Ser Val Val Pro Thr Ala Ala
Thr Ala Val Ser Leu Lys 900 905 910 Val Val Ala Arg Gly Ser Phe Glu
Phe Pro Val Gly Asp Ala Val Ser 915 920 925 Lys Val Leu Gln Ile Glu
Lys Glu Gly Ala Ile His Arg Glu Glu Leu 930 935 940 Val Tyr Glu Leu
Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 945 950 955 960 Pro
Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 965 970
975 Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu
980 985 990 Gly Ala Leu Ser Pro Gly Gly Val Ala Ser Leu Leu Arg Leu
Pro Arg 995 1000 1005 Gly Cys Gly Glu Gln Thr Met Ile Tyr Leu Ala
Pro Thr Leu Ala 1010 1015 1020 Ala Ser Arg Tyr Leu Asp Lys Thr Glu
Gln Trp Ser Thr Leu Pro 1025 1030 1035 Pro Glu Thr Lys Asp His Ala
Val Asp Leu Ile Gln Lys Gly Tyr 1040 1045 1050 Met Arg Ile Gln Gln
Phe Arg Lys Ala Asp Gly Ser Tyr Ala Ala 1055 1060 1065 Trp Leu Ser
Arg Gly Ser Ser Thr Trp Leu Thr Ala Phe Val Leu 1070 1075 1080 Lys
Val Leu Ser Leu Ala Gln Glu Gln Val Gly Gly Ser Pro Glu 1085 1090
1095 Lys Leu Gln Glu Thr Ser Asn Trp Leu Leu Ser Gln Gln Gln Ala
1100 1105 1110 Asp Gly Ser Phe Gln Asp Leu Ser Pro Val Ile His Arg
Ser Met 1115 1120 1125 Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val
Ala Leu Thr Ala 1130 1135 1140 Phe Val Thr Ile Ala Leu His His Gly
Leu Ala Val Phe Gln Asp 1145 1150 1155 Glu Gly Ala Glu Pro Leu Lys
Gln Arg Val Glu Ala Ser Ile Ser 1160 1165 1170 Lys Ala Ser Ser Phe
Leu Gly Glu Lys Ala Ser Ala Gly Leu Leu 1175 1180 1185 Gly Ala His
Ala Ala Ala Ile Thr Ala Tyr Ala Leu Thr Leu Thr 1190 1195 1200 Lys
Ala Pro Ala Asp Leu Arg Gly Val Ala His Asn Asn Leu Met 1205 1210
1215 Ala Met Ala Gln Glu Thr Gly Asp Asn Leu Tyr Trp Gly Ser Val
1220 1225 1230 Thr Gly Ser Gln Ser Asn Ala Val Ser Pro Thr Pro Ala
Pro Arg 1235 1240 1245 Asn Pro Ser Asp Pro Met Pro Gln Ala Pro Ala
Leu Trp Ile Glu 1250 1255 1260 Thr Thr Ala Tyr Ala Leu Leu His Leu
Leu Leu His Glu Gly Lys 1265 1270 1275 Ala Glu Met Ala Asp Gln Ala
Ala Ala Trp Leu Thr Arg Gln Gly 1280 1285 1290 Ser Phe Gln Gly Gly
Phe Arg Ser Thr Gln Asp Thr Val Ile Ala 1295 1300 1305 Leu Asp Ala
Leu Ser Ala Tyr Trp Ile Ala Ser His Thr Thr Glu 1310 1315 1320 Glu
Arg Gly Leu Asn Val Thr Leu Ser Ser Thr Gly Arg Asn Gly 1325 1330
1335 Phe Lys Ser His Ala Leu Gln Leu Asn Asn Arg Gln Ile Arg Gly
1340 1345 1350 Leu Glu Glu Glu Leu Gln Phe Ser Leu Gly Ser Lys Ile
Asn Val 1355 1360 1365 Lys Val Gly Gly Asn Ser Lys Gly Thr Leu Lys
Val Leu Arg Thr 1370 1375 1380 Tyr Asn Val Leu Asp Met Lys Asn Thr
Thr Cys Gln Asp Leu Gln 1385 1390 1395 Ile Glu Val Thr Val Lys Gly
His Val Glu Tyr Thr Met Glu Ala 1400 1405 1410 Asn Glu Asp Tyr Glu
Asp Tyr Glu Tyr Asp Glu Leu Pro Ala Lys 1415 1420 1425 Asp Asp Pro
Asp Ala Pro Leu Gln Pro Val Thr Pro Leu Gln Leu 1430 1435 1440 Phe
Glu Gly Arg Arg Asn Arg Arg Arg Arg Glu Ala Pro Lys Val 1445 1450
1455 Val Glu Glu Gln Glu Ser Arg Val His Tyr Thr Val Cys Ile Trp
1460 1465 1470 Arg Asn Gly Lys Val Gly Leu Ser Gly Met Ala Ile Ala
Asp Val 1475 1480 1485 Thr Leu Leu Ser Gly Phe His Ala Leu Arg Ala
Asp Leu Glu Lys 1490 1495 1500 Leu Thr Ser Leu Ser Asp Arg Tyr Val
Ser His Phe Glu Thr Glu 1505 1510 1515 Gly Pro His Val Leu Leu Tyr
Phe Asp Ser Val Pro Thr Ser Arg 1520 1525 1530 Glu Cys Val Gly Phe
Glu Ala Val Gln Glu Val Pro Val Gly Leu 1535 1540 1545 Val Gln Pro
Ala Ser Ala Thr Leu Tyr Asp Tyr Tyr Asn Pro Glu 1550 1555 1560 Arg
Arg Cys Ser Val Phe Tyr Gly Ala Pro Ser Lys Ser Arg Leu 1565 1570
1575 Leu Ala Thr Leu Cys Ser Ala Glu Val Cys Gln Cys Ala Glu Gly
1580 1585 1590 Lys Cys Pro Arg Gln Arg Arg Ala Leu Glu Arg Gly Leu
Gln Asp 1595 1600 1605 Glu Asp Gly Tyr Arg Met Lys Phe Ala Cys Tyr
Tyr Pro Arg Val 1610 1615 1620 Glu Tyr Gly Phe Gln Val Lys Val Leu
Arg Glu Asp Ser Arg Ala 1625 1630 1635 Ala Phe Arg Leu Phe Glu Thr
Lys Ile Thr Gln Val Leu His Phe 1640 1645 1650 Thr Lys Asp Val Lys
Ala Ala Ala Asn Gln Met Arg Asn Phe Leu 1655 1660 1665 Val Arg Ala
Ser Cys Arg Leu Arg Leu Glu Pro Gly Lys Glu Tyr 1670 1675 1680 Leu
Ile Met Gly Leu Asp Gly Ala Thr Tyr Asp Leu Glu Gly His 1685 1690
1695 Pro Gln Tyr Leu Leu Asp Ser Asn Ser Trp Ile Glu Glu Met Pro
1700 1705 1710 Ser Glu Arg Leu Cys Arg Ser Thr Arg Gln Arg Ala Ala
Cys Ala 1715 1720 1725 Gln Leu Asn Asp Phe Leu Gln Glu Tyr Gly Thr
Gln Gly Cys Gln 1730 1735 1740 Val 2961676PRTHomo sapiens 296Met
Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Thr 1 5 10
15 Trp Gly Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg
20 25 30 Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr
Thr Glu 35 40 45 Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro
Asp Lys Lys Phe 50 55 60 Ser Tyr Ser Ser Gly His Val His Leu Ser
Ser Glu Asn Lys Phe Gln 65 70 75 80 Asn Ser Ala Ile Leu Thr Ile Gln
Pro Lys Gln Leu Pro Gly Gly Gln 85 90 95 Asn Pro Val Ser Tyr Val
Tyr Leu Glu Val Val Ser Lys His Phe Ser 100 105 110 Lys Ser Lys Arg
Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile 115 120 125 His Thr
Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg 130 135 140
Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val 145
150 155 160 Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val
Glu Glu 165 170 175 Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe
Lys Ile Pro Ser 180 185 190 Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys
Ala Lys Tyr Lys Glu Asp 195 200 205 Phe Ser Thr Thr Gly Thr Ala Tyr
Phe Glu Val Lys Glu Tyr Val Leu 210 215 220 Pro His Phe Ser Val Ser
Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr 225 230 235 240 Lys Asn Phe
Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr 245 250 255 Asn
Lys Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg 260 265
270 Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln
275 280 285 Asn Thr Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp
Ser Glu 290 295 300 Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu
Asp Leu Asn Asn 305 310 315 320 Lys Tyr Leu Tyr Ile Ala Val Thr Val
Ile Glu Ser Thr Gly Gly Phe 325 330 335 Ser Glu Glu Ala Glu Ile Pro
Gly Ile Lys Tyr Val Leu Ser Pro Tyr 340 345 350 Lys Leu Asn Leu Val
Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro 355 360 365 Tyr Pro Ile
Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly 370 375 380 Gly
Val Pro Val Thr Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu 385 390
395 400 Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp
Gly 405 410 415 Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr
Val Leu Glu 420 425 430 Phe Asn Val Lys Thr Asp Ala Pro Asp Leu Pro
Glu Glu Asn Gln Ala 435 440 445 Arg Glu Gly Tyr Arg Ala Ile Ala Tyr
Ser Ser Leu Ser Gln Ser Tyr 450 455 460 Leu Tyr Ile Asp Trp Thr Asp
Asn His Lys Ala Leu Leu Val Gly Glu 465 470 475 480 His Leu Asn Ile
Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile 485 490 495 Thr His
Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe 500 505 510
Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile 515
520 525 Pro Val Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr
Tyr 530 535 540 Ile Val Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp
Ser Val Trp 545 550 555 560 Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln
Leu Gln Val His Leu Ser 565 570 575 Pro Asp Ala Asp Ala Tyr Ser Pro
Gly Gln Thr Val Ser Leu Asn Met 580 585 590 Ala Thr Gly Met Asp Ser
Trp Val Ala Leu Ala Ala Val Asp Ser Ala 595 600 605 Val Tyr Gly Val
Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe 610 615 620 Gln Phe
Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu 625 630 635
640 Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn
645 650 655 Ala Asn Ala
Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile 660 665 670 Leu
Arg Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala 675 680
685 Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys
690 695 700 Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile
Ser Leu 705 710 715 720 Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu Cys
Cys Val Val Ala Ser 725 730 735 Gln Leu Arg Ala Asn Ile Ser His Lys
Asp Met Gln Leu Gly Arg Leu 740 745 750 His Met Lys Thr Leu Leu Pro
Val Ser Lys Pro Glu Ile Arg Ser Tyr 755 760 765 Phe Pro Glu Ser Trp
Leu Trp Glu Val His Leu Val Pro Arg Arg Lys 770 775 780 Gln Leu Gln
Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln 785 790 795 800
Gly Val Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys 805
810 815 Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr
Ser 820 825 830 Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val
Tyr Asn Tyr 835 840 845 Arg Thr Ser Gly Met Gln Phe Cys Val Lys Met
Ser Ala Val Glu Gly 850 855 860 Ile Cys Thr Ser Glu Ser Pro Val Ile
Asp His Gln Gly Thr Lys Ser 865 870 875 880 Ser Lys Cys Val Arg Gln
Lys Val Glu Gly Ser Ser Ser His Leu Val 885 890 895 Thr Phe Thr Val
Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe 900 905 910 Ser Leu
Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg 915 920 925
Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu 930
935 940 Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe
Pro 945 950 955 960 Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu
Ile Lys Arg Ile 965 970 975 Leu Ser Val Lys Gly Leu Leu Val Gly Glu
Ile Leu Ser Ala Val Leu 980 985 990 Ser Gln Glu Gly Ile Asn Ile Leu
Thr His Leu Pro Lys Gly Ser Ala 995 1000 1005 Glu Ala Glu Leu Met
Ser Val Val Pro Val Phe Tyr Val Phe His 1010 1015 1020 Tyr Leu Glu
Thr Gly Asn His Trp Asn Ile Phe His Ser Asp Pro 1025 1030 1035 Leu
Ile Glu Lys Gln Lys Leu Lys Lys Lys Leu Lys Glu Gly Met 1040 1045
1050 Leu Ser Ile Met Ser Tyr Arg Asn Ala Asp Tyr Ser Tyr Ser Val
1055 1060 1065 Trp Lys Gly Gly Ser Ala Ser Thr Trp Leu Thr Ala Phe
Ala Leu 1070 1075 1080 Arg Val Leu Gly Gln Val Asn Lys Tyr Val Glu
Gln Asn Gln Asn 1085 1090 1095 Ser Ile Cys Asn Ser Leu Leu Trp Leu
Val Glu Asn Tyr Gln Leu 1100 1105 1110 Asp Asn Gly Ser Phe Lys Glu
Asn Ser Gln Tyr Gln Pro Ile Lys 1115 1120 1125 Leu Gln Gly Thr Leu
Pro Val Glu Ala Arg Glu Asn Ser Leu Tyr 1130 1135 1140 Leu Thr Ala
Phe Thr Val Ile Gly Ile Arg Lys Ala Phe Asp Ile 1145 1150 1155 Cys
Pro Leu Val Lys Ile Asp Thr Ala Leu Ile Lys Ala Asp Asn 1160 1165
1170 Phe Leu Leu Glu Asn Thr Leu Pro Ala Gln Ser Thr Phe Thr Leu
1175 1180 1185 Ala Ile Ser Ala Tyr Ala Leu Ser Leu Gly Asp Lys Thr
His Pro 1190 1195 1200 Gln Phe Arg Ser Ile Val Ser Ala Leu Lys Arg
Glu Ala Leu Val 1205 1210 1215 Lys Gly Asn Pro Pro Ile Tyr Arg Phe
Trp Lys Asp Asn Leu Gln 1220 1225 1230 His Lys Asp Ser Ser Val Pro
Asn Thr Gly Thr Ala Arg Met Val 1235 1240 1245 Glu Thr Thr Ala Tyr
Ala Leu Leu Thr Ser Leu Asn Leu Lys Asp 1250 1255 1260 Ile Asn Tyr
Val Asn Pro Val Ile Lys Trp Leu Ser Glu Glu Gln 1265 1270 1275 Arg
Tyr Gly Gly Gly Phe Tyr Ser Thr Gln Asp Thr Ile Asn Ala 1280 1285
1290 Ile Glu Gly Leu Thr Glu Tyr Ser Leu Leu Val Lys Gln Leu Arg
1295 1300 1305 Leu Ser Met Asp Ile Asp Val Ser Tyr Lys His Lys Gly
Ala Leu 1310 1315 1320 His Asn Tyr Lys Met Thr Asp Lys Asn Phe Leu
Gly Arg Pro Val 1325 1330 1335 Glu Val Leu Leu Asn Asp Asp Leu Ile
Val Ser Thr Gly Phe Gly 1340 1345 1350 Ser Gly Leu Ala Thr Val His
Val Thr Thr Val Val His Lys Thr 1355 1360 1365 Ser Thr Ser Glu Glu
Val Cys Ser Phe Tyr Leu Lys Ile Asp Thr 1370 1375 1380 Gln Asp Ile
Glu Ala Ser His Tyr Arg Gly Tyr Gly Asn Ser Asp 1385 1390 1395 Tyr
Lys Arg Ile Val Ala Cys Ala Ser Tyr Lys Pro Ser Arg Glu 1400 1405
1410 Glu Ser Ser Ser Gly Ser Ser His Ala Val Met Asp Ile Ser Leu
1415 1420 1425 Pro Thr Gly Ile Ser Ala Asn Glu Glu Asp Leu Lys Ala
Leu Val 1430 1435 1440 Glu Gly Val Asp Gln Leu Phe Thr Asp Tyr Gln
Ile Lys Asp Gly 1445 1450 1455 His Val Ile Leu Gln Leu Asn Ser Ile
Pro Ser Ser Asp Phe Leu 1460 1465 1470 Cys Val Arg Phe Arg Ile Phe
Glu Leu Phe Glu Val Gly Phe Leu 1475 1480 1485 Ser Pro Ala Thr Phe
Thr Val Tyr Glu Tyr His Arg Pro Asp Lys 1490 1495 1500 Gln Cys Thr
Met Phe Tyr Ser Thr Ser Asn Ile Lys Ile Gln Lys 1505 1510 1515 Val
Cys Glu Gly Ala Ala Cys Lys Cys Val Glu Ala Asp Cys Gly 1520 1525
1530 Gln Met Gln Glu Glu Leu Asp Leu Thr Ile Ser Ala Glu Thr Arg
1535 1540 1545 Lys Gln Thr Ala Cys Lys Pro Glu Ile Ala Tyr Ala Tyr
Lys Val 1550 1555 1560 Ser Ile Thr Ser Ile Thr Val Glu Asn Val Phe
Val Lys Tyr Lys 1565 1570 1575 Ala Thr Leu Leu Asp Ile Tyr Lys Thr
Gly Glu Ala Val Ala Glu 1580 1585 1590 Lys Asp Ser Glu Ile Thr Phe
Ile Lys Lys Val Thr Cys Thr Asn 1595 1600 1605 Ala Glu Leu Val Lys
Gly Arg Gln Tyr Leu Ile Met Gly Lys Glu 1610 1615 1620 Ala Leu Gln
Ile Lys Tyr Asn Phe Ser Phe Arg Tyr Ile Tyr Pro 1625 1630 1635 Leu
Asp Ser Leu Thr Trp Ile Glu Tyr Trp Pro Arg Asp Thr Thr 1640 1645
1650 Cys Ser Ser Cys Gln Ala Phe Leu Ala Asn Leu Asp Glu Phe Ala
1655 1660 1665 Glu Asp Ile Phe Leu Asn Gly Cys 1670 1675
297934PRTHomo sapiens 297Met Ala Arg Arg Ser Val Leu Tyr Phe Ile
Leu Leu Asn Ala Leu Ile 1 5 10 15 Asn Lys Gly Gln Ala Cys Phe Cys
Asp His Tyr Ala Trp Thr Gln Trp 20 25 30 Thr Ser Cys Ser Lys Thr
Cys Asn Ser Gly Thr Gln Ser Arg His Arg 35 40 45 Gln Ile Val Val
Asp Lys Tyr Tyr Gln Glu Asn Phe Cys Glu Gln Ile 50 55 60 Cys Ser
Lys Gln Glu Thr Arg Glu Cys Asn Trp Gln Arg Cys Pro Ile 65 70 75 80
Asn Cys Leu Leu Gly Asp Phe Gly Pro Trp Ser Asp Cys Asp Pro Cys 85
90 95 Ile Glu Lys Gln Ser Lys Val Arg Ser Val Leu Arg Pro Ser Gln
Phe 100 105 110 Gly Gly Gln Pro Cys Thr Glu Pro Leu Val Ala Phe Gln
Pro Cys Ile 115 120 125 Pro Ser Lys Leu Cys Lys Ile Glu Glu Ala Asp
Cys Lys Asn Lys Phe 130 135 140 Arg Cys Asp Ser Gly Arg Cys Ile Ala
Arg Lys Leu Glu Cys Asn Gly 145 150 155 160 Glu Asn Asp Cys Gly Asp
Asn Ser Asp Glu Arg Asp Cys Gly Arg Thr 165 170 175 Lys Ala Val Cys
Thr Arg Lys Tyr Asn Pro Ile Pro Ser Val Gln Leu 180 185 190 Met Gly
Asn Gly Phe His Phe Leu Ala Gly Glu Pro Arg Gly Glu Val 195 200 205
Leu Asp Asn Ser Phe Thr Gly Gly Ile Cys Lys Thr Val Lys Ser Ser 210
215 220 Arg Thr Ser Asn Pro Tyr Arg Val Pro Ala Asn Leu Glu Asn Val
Gly 225 230 235 240 Phe Glu Val Gln Thr Ala Glu Asp Asp Leu Lys Thr
Asp Phe Tyr Lys 245 250 255 Asp Leu Thr Ser Leu Gly His Asn Glu Asn
Gln Gln Gly Ser Phe Ser 260 265 270 Ser Gln Gly Gly Ser Ser Phe Ser
Val Pro Ile Phe Tyr Ser Ser Lys 275 280 285 Arg Ser Glu Asn Ile Asn
His Asn Ser Ala Phe Lys Gln Ala Ile Gln 290 295 300 Ala Ser His Lys
Lys Asp Ser Ser Phe Ile Arg Ile His Lys Val Met 305 310 315 320 Lys
Val Leu Asn Phe Thr Thr Lys Ala Lys Asp Leu His Leu Ser Asp 325 330
335 Val Phe Leu Lys Ala Leu Asn His Leu Pro Leu Glu Tyr Asn Ser Ala
340 345 350 Leu Tyr Ser Arg Ile Phe Asp Asp Phe Gly Thr His Tyr Phe
Thr Ser 355 360 365 Gly Ser Leu Gly Gly Val Tyr Asp Leu Leu Tyr Gln
Phe Ser Ser Glu 370 375 380 Glu Leu Lys Asn Ser Gly Leu Thr Glu Glu
Glu Ala Lys His Cys Val 385 390 395 400 Arg Ile Glu Thr Lys Lys Arg
Val Leu Phe Ala Lys Lys Thr Lys Val 405 410 415 Glu His Arg Cys Thr
Thr Asn Lys Leu Ser Glu Lys His Glu Gly Ser 420 425 430 Phe Ile Gln
Gly Ala Glu Lys Ser Ile Ser Leu Ile Arg Gly Gly Arg 435 440 445 Ser
Glu Tyr Gly Ala Ala Leu Ala Trp Glu Lys Gly Ser Ser Gly Leu 450 455
460 Glu Glu Lys Thr Phe Ser Glu Trp Leu Glu Ser Val Lys Glu Asn Pro
465 470 475 480 Ala Val Ile Asp Phe Glu Leu Ala Pro Ile Val Asp Leu
Val Arg Asn 485 490 495 Ile Pro Cys Ala Val Thr Lys Arg Asn Asn Leu
Arg Lys Ala Leu Gln 500 505 510 Glu Tyr Ala Ala Lys Phe Asp Pro Cys
Gln Cys Ala Pro Cys Pro Asn 515 520 525 Asn Gly Arg Pro Thr Leu Ser
Gly Thr Glu Cys Leu Cys Val Cys Gln 530 535 540 Ser Gly Thr Tyr Gly
Glu Asn Cys Glu Lys Gln Ser Pro Asp Tyr Lys 545 550 555 560 Ser Asn
Ala Val Asp Gly Gln Trp Gly Cys Trp Ser Ser Trp Ser Thr 565 570 575
Cys Asp Ala Thr Tyr Lys Arg Ser Arg Thr Arg Glu Cys Asn Asn Pro 580
585 590 Ala Pro Gln Arg Gly Gly Lys Arg Cys Glu Gly Glu Lys Arg Gln
Glu 595 600 605 Glu Asp Cys Thr Phe Ser Ile Met Glu Asn Asn Gly Gln
Pro Cys Ile 610 615 620 Asn Asp Asp Glu Glu Met Lys Glu Val Asp Leu
Pro Glu Ile Glu Ala 625 630 635 640 Asp Ser Gly Cys Pro Gln Pro Val
Pro Pro Glu Asn Gly Phe Ile Arg 645 650 655 Asn Glu Lys Gln Leu Tyr
Leu Val Gly Glu Asp Val Glu Ile Ser Cys 660 665 670 Leu Thr Gly Phe
Glu Thr Val Gly Tyr Gln Tyr Phe Arg Cys Leu Pro 675 680 685 Asp Gly
Thr Trp Arg Gln Gly Asp Val Glu Cys Gln Arg Thr Glu Cys 690 695 700
Ile Lys Pro Val Val Gln Glu Val Leu Thr Ile Thr Pro Phe Gln Arg 705
710 715 720 Leu Tyr Arg Ile Gly Glu Ser Ile Glu Leu Thr Cys Pro Lys
Gly Phe 725 730 735 Val Val Ala Gly Pro Ser Arg Tyr Thr Cys Gln Gly
Asn Ser Trp Thr 740 745 750 Pro Pro Ile Ser Asn Ser Leu Thr Cys Glu
Lys Asp Thr Leu Thr Lys 755 760 765 Leu Lys Gly His Cys Gln Leu Gly
Gln Lys Gln Ser Gly Ser Glu Cys 770 775 780 Ile Cys Met Ser Pro Glu
Glu Asp Cys Ser His His Ser Glu Asp Leu 785 790 795 800 Cys Val Phe
Asp Thr Asp Ser Asn Asp Tyr Phe Thr Ser Pro Ala Cys 805 810 815 Lys
Phe Leu Ala Glu Lys Cys Leu Asn Asn Gln Gln Leu His Phe Leu 820 825
830 His Ile Gly Ser Cys Gln Asp Gly Arg Gln Leu Glu Trp Gly Leu Glu
835 840 845 Arg Thr Arg Leu Ser Ser Asn Ser Thr Lys Lys Glu Ser Cys
Gly Tyr 850 855 860 Asp Thr Cys Tyr Asp Trp Glu Lys Cys Ser Ala Ser
Thr Ser Lys Cys 865 870 875 880 Val Cys Leu Leu Pro Pro Gln Cys Phe
Lys Gly Gly Asn Gln Leu Tyr 885 890 895 Cys Val Lys Met Gly Ser Ser
Thr Ser Glu Lys Thr Leu Asn Ile Cys 900 905 910 Glu Val Gly Thr Ile
Arg Cys Ala Asn Arg Lys Met Glu Ile Leu His 915 920 925 Pro Gly Lys
Cys Leu Ala 930 298843PRTHomo sapiens 298Met Lys Val Ile Ser Leu
Phe Ile Leu Val Gly Phe Ile Gly Glu Phe 1 5 10 15 Gln Ser Phe Ser
Ser Ala Ser Ser Pro Val Asn Cys Gln Trp Asp Phe 20 25 30 Tyr Ala
Pro Trp Ser Glu Cys Asn Gly Cys Thr Lys Thr Gln Thr Arg 35 40 45
Arg Arg Ser Val Ala Val Tyr Gly Gln Tyr Gly Gly Gln Pro Cys Val 50
55 60 Gly Asn Ala Phe Glu Thr Gln Ser Cys Glu Pro Thr Arg Gly Cys
Pro 65 70 75 80 Thr Glu Glu Gly Cys Gly Glu Arg Phe Arg Cys Phe Ser
Gly Gln Cys 85 90 95 Ile Ser Lys Ser Leu Val Cys Asn Gly Asp Ser
Asp Cys Asp Glu Asp 100 105 110 Ser Ala Asp Glu Asp Arg Cys Glu Asp
Ser Glu Arg Arg Pro Ser Cys 115 120 125 Asp Ile Asp Lys Pro Pro Pro
Asn Ile Glu Leu Thr Gly Asn Gly Tyr 130 135 140 Asn Glu Leu Thr Gly
Gln Phe Arg Asn Arg Val Ile Asn Thr Lys Ser 145 150 155 160 Phe Gly
Gly Gln Cys Arg Lys Val Phe Ser Gly Asp Gly Lys Asp Phe 165 170 175
Tyr Arg Leu Ser Gly Asn Val Leu Ser Tyr Thr Phe Gln Val Lys Ile 180
185 190 Asn Asn Asp Phe Asn Tyr Glu Phe Tyr Asn Ser Thr Trp Ser Tyr
Val 195 200 205 Lys His Thr Ser Thr Glu His Thr Ser Ser Ser Arg Lys
Arg Ser Phe 210 215 220 Phe Arg Ser Ser Ser Ser Ser Ser Arg Ser Tyr
Thr Ser His Thr Asn 225 230 235 240 Glu Ile His Lys Gly Lys Ser Tyr
Gln Leu Leu Val Val Glu Asn Thr 245 250 255 Val Glu Val Ala Gln Phe
Ile Asn Asn Asn Pro Glu Phe Leu Gln Leu 260 265 270 Ala Glu Pro Phe
Trp Lys Glu Leu Ser His Leu Pro Ser Leu Tyr Asp 275 280 285 Tyr Ser
Ala Tyr Arg Arg Leu Ile Asp Gln Tyr Gly Thr His Tyr Leu 290 295 300
Gln Ser Gly Ser Leu Gly Gly Glu Tyr Arg Val Leu Phe Tyr Val Asp
305
310 315 320 Ser Glu Lys Leu Lys Gln Asn Asp Phe Asn Ser Val Glu Glu
Lys Lys 325 330 335 Cys Lys Ser Ser Gly Trp His Phe Val Val Lys Phe
Ser Ser His Gly 340 345 350 Cys Lys Glu Leu Glu Asn Ala Leu Lys Ala
Ala Ser Gly Thr Gln Asn 355 360 365 Asn Val Leu Arg Gly Glu Pro Phe
Ile Arg Gly Gly Gly Ala Gly Phe 370 375 380 Ile Ser Gly Leu Ser Tyr
Leu Glu Leu Asp Asn Pro Ala Gly Asn Lys 385 390 395 400 Arg Arg Tyr
Ser Ala Trp Ala Glu Ser Val Thr Asn Leu Pro Gln Val 405 410 415 Ile
Lys Gln Lys Leu Thr Pro Leu Tyr Glu Leu Val Lys Glu Val Pro 420 425
430 Cys Ala Ser Val Lys Lys Leu Tyr Leu Lys Trp Ala Leu Glu Glu Tyr
435 440 445 Leu Asp Glu Phe Asp Pro Cys His Cys Arg Pro Cys Gln Asn
Gly Gly 450 455 460 Leu Ala Thr Val Glu Gly Thr His Cys Leu Cys His
Cys Lys Pro Tyr 465 470 475 480 Thr Phe Gly Ala Ala Cys Glu Gln Gly
Val Leu Val Gly Asn Gln Ala 485 490 495 Gly Gly Val Asp Gly Gly Trp
Ser Cys Trp Ser Ser Trp Ser Pro Cys 500 505 510 Val Gln Gly Lys Lys
Thr Arg Ser Arg Glu Cys Asn Asn Pro Pro Pro 515 520 525 Ser Gly Gly
Gly Arg Ser Cys Val Gly Glu Thr Thr Glu Ser Thr Gln 530 535 540 Cys
Glu Asp Glu Glu Leu Glu His Leu Arg Leu Leu Glu Pro His Cys 545 550
555 560 Phe Pro Leu Ser Leu Val Pro Thr Glu Phe Cys Pro Ser Pro Pro
Ala 565 570 575 Leu Lys Asp Gly Phe Val Gln Asp Glu Gly Thr Met Phe
Pro Val Gly 580 585 590 Lys Asn Val Val Tyr Thr Cys Asn Glu Gly Tyr
Ser Leu Ile Gly Asn 595 600 605 Pro Val Ala Arg Cys Gly Glu Asp Leu
Arg Trp Leu Val Gly Glu Met 610 615 620 His Cys Gln Lys Ile Ala Cys
Val Leu Pro Val Leu Met Asp Gly Ile 625 630 635 640 Gln Ser His Pro
Gln Lys Pro Phe Tyr Thr Val Gly Glu Lys Val Thr 645 650 655 Val Ser
Cys Ser Gly Gly Met Ser Leu Glu Gly Pro Ser Ala Phe Leu 660 665 670
Cys Gly Ser Ser Leu Lys Trp Ser Pro Glu Met Lys Asn Ala Arg Cys 675
680 685 Val Gln Lys Glu Asn Pro Leu Thr Gln Ala Val Pro Lys Cys Gln
Arg 690 695 700 Trp Glu Lys Leu Gln Asn Ser Arg Cys Val Cys Lys Met
Pro Tyr Glu 705 710 715 720 Cys Gly Pro Ser Leu Asp Val Cys Ala Gln
Asp Glu Arg Ser Lys Arg 725 730 735 Ile Leu Pro Leu Thr Val Cys Lys
Met His Val Leu His Cys Gln Gly 740 745 750 Arg Asn Tyr Thr Leu Thr
Gly Arg Asp Ser Cys Thr Leu Pro Ala Ser 755 760 765 Ala Glu Lys Ala
Cys Gly Ala Cys Pro Leu Trp Gly Lys Cys Asp Ala 770 775 780 Glu Ser
Ser Lys Cys Val Cys Arg Glu Ala Ser Glu Cys Glu Glu Glu 785 790 795
800 Gly Phe Ser Ile Cys Val Glu Val Asn Gly Lys Glu Gln Thr Met Ser
805 810 815 Glu Cys Glu Ala Gly Ala Leu Arg Cys Arg Gly Gln Ser Ile
Ser Val 820 825 830 Thr Ser Ile Arg Pro Cys Ala Ala Glu Thr Gln 835
840 299584PRTHomo sapiens 299Met Phe Ala Val Val Phe Phe Ile Leu
Ser Leu Met Thr Cys Gln Pro 1 5 10 15 Gly Val Thr Ala Gln Glu Lys
Val Asn Gln Arg Val Arg Arg Ala Ala 20 25 30 Thr Pro Ala Ala Val
Thr Cys Gln Leu Ser Asn Trp Ser Glu Trp Thr 35 40 45 Asp Cys Phe
Pro Cys Gln Asp Lys Lys Tyr Arg His Arg Ser Leu Leu 50 55 60 Gln
Pro Asn Lys Phe Gly Gly Thr Ile Cys Ser Gly Asp Ile Trp Asp 65 70
75 80 Gln Ala Ser Cys Ser Ser Ser Thr Thr Cys Val Arg Gln Ala Gln
Cys 85 90 95 Gly Gln Asp Phe Gln Cys Lys Glu Thr Gly Arg Cys Leu
Lys Arg His 100 105 110 Leu Val Cys Asn Gly Asp Gln Asp Cys Leu Asp
Gly Ser Asp Glu Asp 115 120 125 Asp Cys Glu Asp Val Arg Ala Ile Asp
Glu Asp Cys Ser Gln Tyr Glu 130 135 140 Pro Ile Pro Gly Ser Gln Lys
Ala Ala Leu Gly Tyr Asn Ile Leu Thr 145 150 155 160 Gln Glu Asp Ala
Gln Ser Val Tyr Asp Ala Ser Tyr Tyr Gly Gly Gln 165 170 175 Cys Glu
Thr Val Tyr Asn Gly Glu Trp Arg Glu Leu Arg Tyr Asp Ser 180 185 190
Thr Cys Glu Arg Leu Tyr Tyr Gly Asp Asp Glu Lys Tyr Phe Arg Lys 195
200 205 Pro Tyr Asn Phe Leu Lys Tyr His Phe Glu Ala Leu Ala Asp Thr
Gly 210 215 220 Ile Ser Ser Glu Phe Tyr Asp Asn Ala Asn Asp Leu Leu
Ser Lys Val 225 230 235 240 Lys Lys Asp Lys Ser Asp Ser Phe Gly Val
Thr Ile Gly Ile Gly Pro 245 250 255 Ala Gly Ser Pro Leu Leu Val Gly
Val Gly Val Ser His Ser Gln Asp 260 265 270 Thr Ser Phe Leu Asn Glu
Leu Asn Lys Tyr Asn Glu Lys Lys Phe Ile 275 280 285 Phe Thr Arg Ile
Phe Thr Lys Val Gln Thr Ala His Phe Lys Met Arg 290 295 300 Lys Asp
Asp Ile Met Leu Asp Glu Gly Met Leu Gln Ser Leu Met Glu 305 310 315
320 Leu Pro Asp Gln Tyr Asn Tyr Gly Met Tyr Ala Lys Phe Ile Asn Asp
325 330 335 Tyr Gly Thr His Tyr Ile Thr Ser Gly Ser Met Gly Gly Ile
Tyr Glu 340 345 350 Tyr Ile Leu Val Ile Asp Lys Ala Lys Met Glu Ser
Leu Gly Ile Thr 355 360 365 Ser Arg Asp Ile Thr Thr Cys Phe Gly Gly
Ser Leu Gly Ile Gln Tyr 370 375 380 Glu Asp Lys Ile Asn Val Gly Gly
Gly Leu Ser Gly Asp His Cys Lys 385 390 395 400 Lys Phe Gly Gly Gly
Lys Thr Glu Arg Ala Arg Lys Ala Met Ala Val 405 410 415 Glu Asp Ile
Ile Ser Arg Val Arg Gly Gly Ser Ser Gly Trp Ser Gly 420 425 430 Gly
Leu Ala Gln Asn Arg Ser Thr Ile Thr Tyr Arg Ser Trp Gly Arg 435 440
445 Ser Leu Lys Tyr Asn Pro Val Val Ile Asp Phe Glu Met Gln Pro Ile
450 455 460 His Glu Val Leu Arg His Thr Ser Leu Gly Pro Leu Glu Ala
Lys Arg 465 470 475 480 Gln Asn Leu Arg Arg Ala Leu Asp Gln Tyr Leu
Met Glu Phe Asn Ala 485 490 495 Cys Arg Cys Gly Pro Cys Phe Asn Asn
Gly Val Pro Ile Leu Glu Gly 500 505 510 Thr Ser Cys Arg Cys Gln Cys
Arg Leu Gly Ser Leu Gly Ala Ala Cys 515 520 525 Glu Gln Thr Gln Thr
Glu Gly Ala Lys Ala Asp Gly Ser Trp Ser Cys 530 535 540 Trp Ser Ser
Trp Ser Val Cys Arg Ala Gly Ile Gln Glu Arg Arg Arg 545 550 555 560
Glu Cys Asp Asn Pro Ala Pro Gln Asn Gly Gly Ala Ser Cys Pro Gly 565
570 575 Arg Lys Val Gln Thr Gln Ala Cys 580 300559PRTHomo sapiens
300Met Ser Ala Cys Arg Ser Phe Ala Val Ala Ile Cys Ile Leu Glu Ile
1 5 10 15 Ser Ile Leu Thr Ala Gln Tyr Thr Thr Ser Tyr Asp Pro Glu
Leu Thr 20 25 30 Glu Ser Ser Gly Ser Ala Ser His Ile Asp Cys Arg
Met Ser Pro Trp 35 40 45 Ser Glu Trp Ser Gln Cys Asp Pro Cys Leu
Arg Gln Met Phe Arg Ser 50 55 60 Arg Ser Ile Glu Val Phe Gly Gln
Phe Asn Gly Lys Arg Cys Thr Asp 65 70 75 80 Ala Val Gly Asp Arg Arg
Gln Cys Val Pro Thr Glu Pro Cys Glu Asp 85 90 95 Ala Glu Asp Asp
Cys Gly Asn Asp Phe Gln Cys Ser Thr Gly Arg Cys 100 105 110 Ile Lys
Met Arg Leu Arg Cys Asn Gly Asp Asn Asp Cys Gly Asp Phe 115 120 125
Ser Asp Glu Asp Asp Cys Glu Ser Glu Pro Arg Pro Pro Cys Arg Asp 130
135 140 Arg Val Val Glu Glu Ser Glu Leu Ala Arg Thr Ala Gly Tyr Gly
Ile 145 150 155 160 Asn Ile Leu Gly Met Asp Pro Leu Ser Thr Pro Phe
Asp Asn Glu Phe 165 170 175 Tyr Asn Gly Leu Cys Asn Arg Asp Arg Asp
Gly Asn Thr Leu Thr Tyr 180 185 190 Tyr Arg Arg Pro Trp Asn Val Ala
Ser Leu Ile Tyr Glu Thr Lys Gly 195 200 205 Glu Lys Asn Phe Arg Thr
Glu His Tyr Glu Glu Gln Ile Glu Ala Phe 210 215 220 Lys Ser Ile Ile
Gln Glu Lys Thr Ser Asn Phe Asn Ala Ala Ile Ser 225 230 235 240 Leu
Lys Phe Thr Pro Thr Glu Thr Asn Lys Ala Glu Gln Cys Cys Glu 245 250
255 Glu Thr Ala Ser Ser Ile Ser Leu His Gly Lys Gly Ser Phe Arg Phe
260 265 270 Ser Tyr Ser Lys Asn Glu Thr Tyr Gln Leu Phe Leu Ser Tyr
Ser Ser 275 280 285 Lys Lys Glu Lys Met Phe Leu His Val Lys Gly Glu
Ile His Leu Gly 290 295 300 Arg Phe Val Met Arg Asn Arg Asp Val Val
Leu Thr Thr Thr Phe Val 305 310 315 320 Asp Asp Ile Lys Ala Leu Pro
Thr Thr Tyr Glu Lys Gly Glu Tyr Phe 325 330 335 Ala Phe Leu Glu Thr
Tyr Gly Thr His Tyr Ser Ser Ser Gly Ser Leu 340 345 350 Gly Gly Leu
Tyr Glu Leu Ile Tyr Val Leu Asp Lys Ala Ser Met Lys 355 360 365 Arg
Lys Gly Val Glu Leu Lys Asp Ile Lys Arg Cys Leu Gly Tyr His 370 375
380 Leu Asp Val Ser Leu Ala Phe Ser Glu Ile Ser Val Gly Ala Glu Phe
385 390 395 400 Asn Lys Asp Asp Cys Val Lys Arg Gly Glu Gly Arg Ala
Val Asn Ile 405 410 415 Thr Ser Glu Asn Leu Ile Asp Asp Val Val Ser
Leu Ile Arg Gly Gly 420 425 430 Thr Arg Lys Tyr Ala Phe Glu Leu Lys
Glu Lys Leu Leu Arg Gly Thr 435 440 445 Val Ile Asp Val Thr Asp Phe
Val Asn Trp Ala Ser Ser Ile Asn Asp 450 455 460 Ala Pro Val Leu Ile
Ser Gln Lys Leu Ser Pro Ile Tyr Asn Leu Val 465 470 475 480 Pro Val
Lys Met Lys Asn Ala His Leu Lys Lys Gln Asn Leu Glu Arg 485 490 495
Ala Ile Glu Asp Tyr Ile Asn Glu Phe Ser Val Arg Lys Cys His Thr 500
505 510 Cys Gln Asn Gly Gly Thr Val Ile Leu Met Asp Gly Lys Cys Leu
Cys 515 520 525 Ala Cys Pro Phe Lys Phe Glu Gly Ile Ala Cys Glu Ile
Ser Lys Gln 530 535 540 Lys Ile Ser Glu Gly Leu Pro Ala Leu Glu Phe
Pro Asn Glu Lys 545 550 555 301764PRTHomo sapiens 301Met Gly Ser
Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 1 5 10 15 Gly
Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Gln 20 25
30 Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser
35 40 45 Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys
Pro Ser 50 55 60 Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys
Arg Ser Thr Gly 65 70 75 80 Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln
Lys Thr Val Arg Lys Ala 85 90 95 Glu Cys Arg Ala Ile His Cys Pro
Arg Pro His Asp Phe Glu Asn Gly 100 105 110 Glu Tyr Trp Pro Arg Ser
Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 115 120 125 Phe His Cys Tyr
Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 130 135 140 Cys Gln
Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 145 150 155
160 Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys
165 170 175 Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His
Cys Ser 180 185 190 Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr
Cys Gln Glu Gly 195 200 205 Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys
Gln Asp Ser Phe Met Tyr 210 215 220 Asp Thr Pro Gln Glu Val Ala Glu
Ala Phe Leu Ser Ser Leu Thr Glu 225 230 235 240 Thr Ile Glu Gly Val
Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 245 250 255 Gln Lys Arg
Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 260 265 270 Leu
Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 275 280
285 Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly
290 295 300 Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro
Lys Ile 305 310 315 320 Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn
Ala Asp Trp Val Thr 325 330 335 Lys Gln Leu Asn Glu Ile Asn Tyr Glu
Asp His Lys Leu Lys Ser Gly 340 345 350 Thr Asn Thr Lys Lys Ala Leu
Gln Ala Val Tyr Ser Met Met Ser Trp 355 360 365 Pro Asp Asp Val Pro
Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 370 375 380 Ile Leu Met
Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 385 390 395 400
Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 405
410 415 Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly
Pro 420 425 430 Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys
Lys Asp Asn 435 440 445 Glu Gln His Val Phe Lys Val Lys Asp Met Glu
Asn Leu Glu Asp Val 450 455 460 Phe Tyr Gln Met Ile Asp Glu Ser Gln
Ser Leu Ser Leu Cys Gly Met 465 470 475 480 Val Trp Glu His Arg Lys
Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 485 490 495 Ala Lys Ile Ser
Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 500 505 510 Gly Ala
Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 515 520 525
Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 530
535 540 Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr
Asn 545 550 555 560 Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe
Tyr Asp Tyr Asp 565 570 575 Val Ala Leu Ile Lys Leu Lys Asn Lys Leu
Lys Tyr Gly Gln Thr Ile 580 585 590 Arg Pro Ile Cys Leu Pro Cys Thr
Glu Gly Thr Thr Arg Ala Leu Arg 595 600 605 Leu Pro Pro Thr Thr Thr
Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 610 615 620 Ala Gln Asp
Ile
Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 625 630 635 640 Thr
Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 645 650
655 Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile
660 665 670 Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val
Ser Pro 675 680 685 Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly
Gly Pro Leu Ile 690 695 700 Val His Lys Arg Ser Arg Phe Ile Gln Val
Gly Val Ile Ser Trp Gly 705 710 715 720 Val Val Asp Val Cys Lys Asn
Gln Lys Arg Gln Lys Gln Val Pro Ala 725 730 735 His Ala Arg Asp Phe
His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 740 745 750 Lys Glu Lys
Leu Gln Asp Glu Asp Leu Gly Phe Leu 755 760 3021231PRTHomo sapiens
302Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys
1 5 10 15 Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr
Glu Ile 20 25 30 Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu
Gly Thr Gln Ala 35 40 45 Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser
Leu Gly Asn Val Ile Met 50 55 60 Val Cys Arg Lys Gly Glu Trp Val
Ala Leu Asn Pro Leu Arg Lys Cys 65 70 75 80 Gln Lys Arg Pro Cys Gly
His Pro Gly Asp Thr Pro Phe Gly Thr Phe 85 90 95 Thr Leu Thr Gly
Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 100 105 110 Thr Cys
Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 115 120 125
Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 130
135 140 Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser
Ser 145 150 155 160 Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln
Ala Val Arg Phe 165 170 175 Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly
Asp Glu Glu Met His Cys 180 185 190 Ser Asp Asp Gly Phe Trp Ser Lys
Glu Lys Pro Lys Cys Val Glu Ile 195 200 205 Ser Cys Lys Ser Pro Asp
Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 210 215 220 Ile Ile Tyr Lys
Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 225 230 235 240 Tyr
Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 245 250
255 Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile
260 265 270 Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr
Gly Asp 275 280 285 Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro
Ala Thr Arg Gly 290 295 300 Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp
Ile Pro Ala Pro Arg Cys 305 310 315 320 Thr Leu Lys Pro Cys Asp Tyr
Pro Asp Ile Lys His Gly Gly Leu Tyr 325 330 335 His Glu Asn Met Arg
Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 340 345 350 Tyr Ser Tyr
Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 355 360 365 Trp
Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 370 375
380 Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln
385 390 395 400 Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp
Val Ala Cys 405 410 415 His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr
Thr Val Thr Cys Met 420 425 430 Glu Asn Gly Trp Ser Pro Thr Pro Arg
Cys Ile Arg Val Lys Thr Cys 435 440 445 Ser Lys Ser Ser Ile Asp Ile
Glu Asn Gly Phe Ile Ser Glu Ser Gln 450 455 460 Tyr Thr Tyr Ala Leu
Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 465 470 475 480 Tyr Val
Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Arg Cys Gly Lys 485 490 495
Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 500
505 510 Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys
Leu 515 520 525 Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu
Ser Asn Thr 530 535 540 Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr
Asn Gly Trp Ser Asp 545 550 555 560 Leu Pro Ile Cys Tyr Glu Arg Glu
Cys Glu Leu Pro Lys Ile Asp Val 565 570 575 His Leu Val Pro Asp Arg
Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 580 585 590 Leu Lys Phe Ser
Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 595 600 605 Val Gln
Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 610 615 620
Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 625
630 635 640 Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val
Val Glu 645 650 655 Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro
Asn Lys Ile Gln 660 665 670 Cys Val Asp Gly Glu Trp Thr Thr Leu Pro
Val Cys Ile Val Glu Glu 675 680 685 Ser Thr Cys Gly Asp Ile Pro Glu
Leu Glu His Gly Trp Ala Gln Leu 690 695 700 Ser Ser Pro Pro Tyr Tyr
Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 705 710 715 720 Glu Ser Phe
Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 725 730 735 Val
Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 740 745
750 Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys
755 760 765 Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg
Gly Lys 770 775 780 Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg
Trp Asp Pro Glu 785 790 795 800 Val Asn Cys Ser Met Ala Gln Ile Gln
Leu Cys Pro Pro Pro Pro Gln 805 810 815 Ile Pro Asn Ser His Asn Met
Thr Thr Thr Leu Asn Tyr Arg Asp Gly 820 825 830 Glu Lys Val Ser Val
Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 835 840 845 Glu Glu Ile
Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 850 855 860 Val
Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 865 870
875 880 Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr
Lys 885 890 895 Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu
Glu Asn Glu 900 905 910 Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro
Pro Gln Cys Glu Gly 915 920 925 Leu Pro Cys Lys Ser Pro Pro Glu Ile
Ser His Gly Val Val Ala His 930 935 940 Met Ser Asp Ser Tyr Gln Tyr
Gly Glu Glu Val Thr Tyr Lys Cys Phe 945 950 955 960 Glu Gly Phe Gly
Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 965 970 975 Lys Trp
Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 980 985 990
Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr 995
1000 1005 Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr
Lys 1010 1015 1020 Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser
Arg Trp Thr 1025 1030 1035 Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys
Val Asn Pro Pro Thr 1040 1045 1050 Val Gln Asn Ala Tyr Ile Val Ser
Arg Gln Met Ser Lys Tyr Pro 1055 1060 1065 Ser Gly Glu Arg Val Arg
Tyr Gln Cys Arg Ser Pro Tyr Glu Met 1070 1075 1080 Phe Gly Asp Glu
Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu 1085 1090 1095 Pro Pro
Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro 1100 1105 1110
Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr 1115
1120 1125 Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr
Gln 1130 1135 1140 Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly
Gln Trp Ser 1145 1150 1155 Glu Pro Pro Lys Cys Leu His Pro Cys Val
Ile Ser Arg Glu Ile 1160 1165 1170 Met Glu Asn Tyr Asn Ile Ala Leu
Arg Trp Thr Ala Lys Gln Lys 1175 1180 1185 Leu Tyr Ser Arg Thr Gly
Glu Ser Val Glu Phe Val Cys Lys Arg 1190 1195 1200 Gly Tyr Arg Leu
Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys 1205 1210 1215 Trp Asp
Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 1220 1225 1230
303644PRTHomo sapiens 303Met Phe Ser Met Arg Ile Val Cys Leu Val
Leu Ser Val Val Gly Thr 1 5 10 15 Ala Trp Thr Ala Asp Ser Gly Glu
Gly Asp Phe Leu Ala Glu Gly Gly 20 25 30 Gly Val Arg Gly Pro Arg
Val Val Glu Arg His Gln Ser Ala Cys Lys 35 40 45 Asp Ser Asp Trp
Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 50 55 60 Pro Ser
Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 65 70 75 80
Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 85
90 95 Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu
Ile 100 105 110 Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn
Thr Tyr Asn 115 120 125 Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu
Val Leu Lys Arg Lys 130 135 140 Val Ile Glu Lys Val Gln His Ile Gln
Leu Leu Gln Lys Asn Val Arg 145 150 155 160 Ala Gln Leu Val Asp Met
Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 165 170 175 Ile Arg Ser Cys
Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 180 185 190 Asp Leu
Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 195 200 205
Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile 210
215 220 Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser
Gln 225 230 235 240 Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr
Asp Met Pro Gln 245 250 255 Met Arg Met Glu Leu Glu Arg Pro Gly Gly
Asn Glu Ile Thr Arg Gly 260 265 270 Gly Ser Thr Ser Tyr Gly Thr Gly
Ser Glu Thr Glu Ser Pro Arg Asn 275 280 285 Pro Ser Ser Ala Gly Ser
Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser 290 295 300 Thr Gly Asn Arg
Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr 305 310 315 320 Trp
Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser 325 330
335 Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro
340 345 350 Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu
Arg Gly 355 360 365 Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser
Gly Ser Thr Gly 370 375 380 Gln Trp His Ser Glu Ser Gly Ser Phe Arg
Pro Asp Ser Pro Gly Ser 385 390 395 400 Gly Asn Ala Arg Pro Asn Asn
Pro Asp Trp Gly Thr Phe Glu Glu Val 405 410 415 Ser Gly Asn Val Ser
Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys 420 425 430 Leu Val Thr
Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys 435 440 445 Val
Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr 450 455
460 Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys
465 470 475 480 Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu
Ala Met Asp 485 490 495 Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp
Gly Phe Arg His Arg 500 505 510 His Pro Asp Glu Ala Ala Phe Phe Asp
Thr Ala Ser Thr Gly Lys Thr 515 520 525 Phe Pro Gly Phe Phe Ser Pro
Met Leu Gly Glu Phe Val Ser Glu Thr 530 535 540 Glu Ser Arg Gly Ser
Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 545 550 555 560 Ser Ser
His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser 565 570 575
Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly 580
585 590 Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala
Gly 595 600 605 Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg
Gly His Ala 610 615 620 Lys Ser Arg Pro Val Arg Gly Ile His Thr Ser
Pro Leu Gly Lys Pro 625 630 635 640 Ser Leu Ser Pro 304491PRTHomo
sapiens 304Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr
Met Lys 1 5 10 15 His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val
Lys Ser Gln Gly 20 25 30 Val Asn Asp Asn Glu Glu Gly Phe Phe Ser
Ala Arg Gly His Arg Pro 35 40 45 Leu Asp Lys Lys Arg Glu Glu Ala
Pro Ser Leu Arg Pro Ala Pro Pro 50 55 60 Pro Ile Ser Gly Gly Gly
Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala 65 70 75 80 Thr Gln Lys Lys
Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu 85 90 95 His Ala
Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys Gln Leu 100 105 110
Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp 115
120 125 Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser Ser
Ser 130 135 140 Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys
Arg Gln Lys 145 150 155 160 Gln Val Lys Asp Asn Glu Asn Val Val Asn
Glu Tyr Ser Ser Glu Leu 165 170 175 Glu Lys His Gln Leu Tyr Ile Asp
Glu Thr Val Asn Ser Asn Ile Ala 180 185 190 Thr Asn Leu Arg Val Leu
Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys 195 200 205 Ile Gln Lys Leu
Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg 210 215 220 Thr Pro
Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu 225 230 235
240 Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu
245 250 255 Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys
Asp Met 260 265 270 Asn
Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly 275 280
285 Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly
290 295 300 Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu
Pro Gly 305 310 315 320 Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln
Leu Thr Arg Met Gly 325 330 335 Pro Thr Glu Leu Leu Ile Glu Met Glu
Asp Trp Lys Gly Asp Lys Val 340 345 350 Lys Ala His Tyr Gly Gly Phe
Thr Val Gln Asn Glu Ala Asn Lys Tyr 355 360 365 Gln Ile Ser Val Asn
Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met 370 375 380 Asp Gly Ala
Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His 385 390 395 400
Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu 405
410 415 Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly
Trp 420 425 430 Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg
Tyr Tyr Trp 435 440 445 Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His
Gly Thr Asp Asp Gly 450 455 460 Val Val Trp Met Asn Trp Lys Gly Ser
Trp Tyr Ser Met Arg Lys Met 465 470 475 480 Ser Met Lys Ile Arg Pro
Phe Phe Pro Gln Gln 485 490 305437PRTHomo sapiens 305Met Ser Trp
Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 1 5 10 15 Leu
Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 20 25
30 Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr
35 40 45 Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val
Asp Lys 50 55 60 Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val
Glu Asn Lys Thr 65 70 75 80 Ser Glu Val Lys Gln Leu Ile Lys Ala Ile
Gln Leu Thr Tyr Asn Pro 85 90 95 Asp Glu Ser Ser Lys Pro Asn Met
Ile Asp Ala Ala Thr Leu Lys Ser 100 105 110 Arg Ile Met Leu Glu Glu
Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 115 120 125 His Asp Ser Ser
Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 130 135 140 Gln Lys
Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 145 150 155
160 Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly
165 170 175 Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser
Gly Leu 180 185 190 Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe
Leu Val Tyr Cys 195 200 205 Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr
Val Phe Gln Lys Arg Leu 210 215 220 Asp Gly Ser Val Asp Phe Lys Lys
Asn Trp Ile Gln Tyr Lys Glu Gly 225 230 235 240 Phe Gly His Leu Ser
Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 245 250 255 Glu Lys Ile
His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 260 265 270 Arg
Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 275 280
285 Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr
290 295 300 Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly
Phe Asp 305 310 315 320 Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr
Ser His Asn Gly Met 325 330 335 Gln Phe Ser Thr Trp Asp Asn Asp Asn
Asp Lys Phe Glu Gly Asn Cys 340 345 350 Ala Glu Gln Asp Gly Ser Gly
Trp Trp Met Asn Lys Cys His Ala Gly 355 360 365 His Leu Asn Gly Val
Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 370 375 380 Thr Pro Asn
Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 385 390 395 400
Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 405
410 415 Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala
Lys 420 425 430 Gln Ala Gly Asp Val 435 3062477PRTHomo sapiens
306Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys
1 5 10 15 Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys
Arg Gln 20 25 30 Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala
Val Ser Gln Ser 35 40 45 Lys Pro Gly Cys Tyr Asp Asn Gly Lys His
Tyr Gln Ile Asn Gln Gln 50 55 60 Trp Glu Arg Thr Tyr Leu Gly Asn
Ala Leu Val Cys Thr Cys Tyr Gly 65 70 75 80 Gly Ser Arg Gly Phe Asn
Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 85 90 95 Cys Phe Asp Lys
Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 100 105 110 Glu Arg
Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 115 120 125
Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 130
135 140 Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu
Thr 145 150 155 160 Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn
Gly Lys Gly Glu 165 170 175 Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys
Phe Asp His Ala Ala Gly 180 185 190 Thr Ser Tyr Val Val Gly Glu Thr
Trp Glu Lys Pro Tyr Gln Gly Trp 195 200 205 Met Met Val Asp Cys Thr
Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 210 215 220 Cys Thr Ser Arg
Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 225 230 235 240 Arg
Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 245 250
255 Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg
260 265 270 His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe
Thr Asp 275 280 285 Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro
Gln Pro Pro Pro 290 295 300 Tyr Gly His Cys Val Thr Asp Ser Gly Val
Val Tyr Ser Val Gly Met 305 310 315 320 Gln Trp Leu Lys Thr Gln Gly
Asn Lys Gln Met Leu Cys Thr Cys Leu 325 330 335 Gly Asn Gly Val Ser
Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 340 345 350 Gly Asn Ser
Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 355 360 365 Arg
Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 370 375
380 Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe
385 390 395 400 Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly
Asn Ser Asn 405 410 415 Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn
Asn His Asn Tyr Thr 420 425 430 Asp Cys Thr Ser Glu Gly Arg Arg Asp
Asn Met Lys Trp Cys Gly Thr 435 440 445 Thr Gln Asn Tyr Asp Ala Asp
Gln Lys Phe Gly Phe Cys Pro Met Ala 450 455 460 Ala His Glu Glu Ile
Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 465 470 475 480 Gly Asp
Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 485 490 495
Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 500
505 510 Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val
Asn 515 520 525 Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu
Asn Cys Thr 530 535 540 Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys
Asp Pro Val Asp Gln 545 550 555 560 Cys Gln Asp Ser Glu Thr Gly Thr
Phe Tyr Gln Ile Gly Asp Ser Trp 565 570 575 Glu Lys Tyr Val His Gly
Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 580 585 590 Gly Ile Gly Glu
Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 595 600 605 Ser Gly
Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 610 615 620
Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 625
630 635 640 Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp
Lys Glu 645 650 655 Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile
Lys Gly Leu Lys 660 665 670 Pro Gly Val Val Tyr Glu Gly Gln Leu Ile
Ser Ile Gln Gln Tyr Gly 675 680 685 His Gln Glu Val Thr Arg Phe Asp
Phe Thr Thr Thr Ser Thr Ser Thr 690 695 700 Pro Val Thr Ser Asn Thr
Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 705 710 715 720 Leu Val Ala
Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 725 730 735 Val
Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 740 745
750 Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu
755 760 765 Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro
Gly Arg 770 775 780 Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp
Gly Glu Gln Ser 785 790 795 800 Leu Ile Leu Ser Thr Ser Gln Thr Thr
Ala Pro Asp Ala Pro Pro Asp 805 810 815 Pro Thr Val Asp Gln Val Asp
Asp Thr Ser Ile Val Val Arg Trp Ser 820 825 830 Arg Pro Gln Ala Pro
Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 835 840 845 Val Glu Gly
Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 850 855 860 Val
Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 865 870
875 880 Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln
Gln 885 890 895 Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser
Pro Arg Asp 900 905 910 Leu Gln Phe Val Glu Val Thr Asp Val Lys Val
Thr Ile Met Trp Thr 915 920 925 Pro Pro Glu Ser Ala Val Thr Gly Tyr
Arg Val Asp Val Ile Pro Val 930 935 940 Asn Leu Pro Gly Glu His Gly
Gln Arg Leu Pro Ile Ser Arg Asn Thr 945 950 955 960 Phe Ala Glu Val
Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 965 970 975 Val Phe
Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 980 985 990
Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu Gln Phe Val Asn Glu 995
1000 1005 Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro Pro Arg Ala
Gln 1010 1015 1020 Ile Thr Gly Tyr Arg Leu Thr Val Gly Leu Thr Arg
Arg Gly Gln 1025 1030 1035 Pro Arg Gln Tyr Asn Val Gly Pro Ser Val
Ser Lys Tyr Pro Leu 1040 1045 1050 Arg Asn Leu Gln Pro Ala Ser Glu
Tyr Thr Val Ser Leu Val Ala 1055 1060 1065 Ile Lys Gly Asn Gln Glu
Ser Pro Lys Ala Thr Gly Val Phe Thr 1070 1075 1080 Thr Leu Gln Pro
Gly Ser Ser Ile Pro Pro Tyr Asn Thr Glu Val 1085 1090 1095 Thr Glu
Thr Thr Ile Val Ile Thr Trp Thr Pro Ala Pro Arg Ile 1100 1105 1110
Gly Phe Lys Leu Gly Val Arg Pro Ser Gln Gly Gly Glu Ala Pro 1115
1120 1125 Arg Glu Val Thr Ser Asp Ser Gly Ser Ile Val Val Ser Gly
Leu 1130 1135 1140 Thr Pro Gly Val Glu Tyr Val Tyr Thr Ile Gln Val
Leu Arg Asp 1145 1150 1155 Gly Gln Glu Arg Asp Ala Pro Ile Val Asn
Lys Val Val Thr Pro 1160 1165 1170 Leu Ser Pro Pro Thr Asn Leu His
Leu Glu Ala Asn Pro Asp Thr 1175 1180 1185 Gly Val Leu Thr Val Ser
Trp Glu Arg Ser Thr Thr Pro Asp Ile 1190 1195 1200 Thr Gly Tyr Arg
Ile Thr Thr Thr Pro Thr Asn Gly Gln Gln Gly 1205 1210 1215 Asn Ser
Leu Glu Glu Val Val His Ala Asp Gln Ser Ser Cys Thr 1220 1225 1230
Phe Asp Asn Leu Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr 1235
1240 1245 Thr Val Lys Asp Asp Lys Glu Ser Val Pro Ile Ser Asp Thr
Ile 1250 1255 1260 Ile Pro Glu Val Pro Gln Leu Thr Asp Leu Ser Phe
Val Asp Ile 1265 1270 1275 Thr Asp Ser Ser Ile Gly Leu Arg Trp Thr
Pro Leu Asn Ser Ser 1280 1285 1290 Thr Ile Ile Gly Tyr Arg Ile Thr
Val Val Ala Ala Gly Glu Gly 1295 1300 1305 Ile Pro Ile Phe Glu Asp
Phe Val Asp Ser Ser Val Gly Tyr Tyr 1310 1315 1320 Thr Val Thr Gly
Leu Glu Pro Gly Ile Asp Tyr Asp Ile Ser Val 1325 1330 1335 Ile Thr
Leu Ile Asn Gly Gly Glu Ser Ala Pro Thr Thr Leu Thr 1340 1345 1350
Gln Gln Thr Ala Val Pro Pro Pro Thr Asp Leu Arg Phe Thr Asn 1355
1360 1365 Ile Gly Pro Asp Thr Met Arg Val Thr Trp Ala Pro Pro Pro
Ser 1370 1375 1380 Ile Asp Leu Thr Asn Phe Leu Val Arg Tyr Ser Pro
Val Lys Asn 1385 1390 1395 Glu Glu Asp Val Ala Glu Leu Ser Ile Ser
Pro Ser Asp Asn Ala 1400 1405 1410 Val Val Leu Thr Asn Leu Leu Pro
Gly Thr Glu Tyr Val Val Ser 1415 1420 1425 Val Ser Ser Val Tyr Glu
Gln His Glu Ser Thr Pro Leu Arg Gly 1430 1435 1440 Arg Gln Lys Thr
Gly Leu Asp Ser Pro Thr Gly Ile Asp Phe Ser 1445 1450 1455 Asp Ile
Thr Ala Asn Ser Phe Thr Val His Trp Ile Ala Pro Arg 1460 1465 1470
Ala Thr Ile Thr Gly Tyr Arg Ile Arg His His Pro Glu His Phe 1475
1480 1485 Ser Gly Arg Pro Arg Glu Asp Arg Val Pro His Ser Arg Asn
Ser 1490 1495 1500 Ile Thr Leu Thr Asn Leu Thr Pro Gly Thr Glu Tyr
Val Val Ser 1505 1510 1515 Ile Val Ala Leu Asn Gly Arg Glu Glu Ser
Pro Leu Leu Ile Gly 1520 1525 1530 Gln Gln Ser Thr Val Ser Asp Val
Pro Arg Asp Leu Glu Val Val 1535 1540 1545 Ala Ala Thr Pro Thr Ser
Leu Leu Ile Ser Trp Asp Ala Pro Ala 1550 1555 1560 Val Thr Val Arg
Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly 1565 1570 1575 Asn Ser
Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 1580 1585 1590
Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr 1595
1600 1605 Val Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro Ala
Ser Ser Lys 1610 1615 1620 Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile
Asp Lys Pro Ser Gln 1625 1630 1635 Met Gln Val Thr Asp Val Gln Asp
Asn Ser Ile Ser Val Lys Trp 1640 1645 1650 Leu Pro Ser Ser Ser Pro
Val Thr Gly Tyr Arg Val Thr Thr Thr 1655 1660 1665 Pro Lys Asn Gly
Pro Gly Pro Thr Lys Thr Lys Thr Ala Gly Pro 1670 1675 1680 Asp Gln
Thr Glu Met Thr Ile Glu Gly Leu Gln Pro Thr Val Glu 1685 1690 1695
Tyr Val Val Ser Val Tyr Ala Gln Asn Pro Ser Gly Glu Ser Gln 1700
1705 1710 Pro Leu Val Gln Thr Ala Val Thr Asn Ile Asp Arg Pro Lys
Gly 1715 1720 1725 Leu Ala Phe Thr Asp Val Asp Val Asp Ser Ile Lys
Ile Ala Trp 1730 1735 1740 Glu Ser Pro Gln Gly Gln Val Ser Arg Tyr
Arg Val Thr Tyr Ser 1745 1750 1755 Ser Pro Glu Asp Gly Ile His Glu
Leu Phe Pro Ala Pro Asp Gly 1760 1765 1770 Glu Glu Asp Thr Ala Glu
Leu Gln Gly Leu Arg Pro Gly Ser Glu 1775 1780 1785 Tyr Thr Val Ser
Val Val Ala Leu His Asp Asp Met Glu Ser Gln 1790 1795 1800 Pro Leu
Ile Gly Thr Gln Ser Thr Ala Ile Pro Ala Pro Thr Asp 1805 1810 1815
Leu Lys Phe Thr Gln Val Thr Pro Thr Ser Leu Ser Ala Gln Trp 1820
1825 1830 Thr Pro Pro Asn Val Gln Leu Thr Gly Tyr Arg Val Arg Val
Thr 1835 1840 1845 Pro Lys Glu Lys Thr Gly Pro Met Lys Glu Ile Asn
Leu Ala Pro 1850 1855 1860 Asp Ser Ser Ser Val Val Val Ser Gly Leu
Met Val Ala Thr Lys 1865 1870 1875 Tyr Glu Val Ser Val Tyr Ala Leu
Lys Asp Thr Leu Thr Ser Arg 1880 1885 1890 Pro Ala Gln Gly Val Val
Thr Thr Leu Glu Asn Val Ser Pro Pro 1895 1900 1905 Arg Arg Ala Arg
Val Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile 1910 1915 1920 Ser Trp
Arg Thr Lys Thr Glu Thr Ile Thr Gly Phe Gln Val Asp 1925 1930 1935
Ala Val Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys 1940
1945 1950 Pro Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly
Thr 1955 1960 1965 Asp Tyr Lys Ile Tyr Leu Tyr Thr Leu Asn Asp Asn
Ala Arg Ser 1970 1975 1980 Ser Pro Val Val Ile Asp Ala Ser Thr Ala
Ile Asp Ala Pro Ser 1985 1990 1995 Asn Leu Arg Phe Leu Ala Thr Thr
Pro Asn Ser Leu Leu Val Ser 2000 2005 2010 Trp Gln Pro Pro Arg Ala
Arg Ile Thr Gly Tyr Ile Ile Lys Tyr 2015 2020 2025 Glu Lys Pro Gly
Ser Pro Pro Arg Glu Val Val Pro Arg Pro Arg 2030 2035 2040 Pro Gly
Val Thr Glu Ala Thr Ile Thr Gly Leu Glu Pro Gly Thr 2045 2050 2055
Glu Tyr Thr Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln Lys Ser 2060
2065 2070 Glu Pro Leu Ile Gly Arg Lys Lys Thr Asp Glu Leu Pro Gln
Leu 2075 2080 2085 Val Thr Leu Pro His Pro Asn Leu His Gly Pro Glu
Ile Leu Asp 2090 2095 2100 Val Pro Ser Thr Val Gln Lys Thr Pro Phe
Val Thr His Pro Gly 2105 2110 2115 Tyr Asp Thr Gly Asn Gly Ile Gln
Leu Pro Gly Thr Ser Gly Gln 2120 2125 2130 Gln Pro Ser Val Gly Gln
Gln Met Ile Phe Glu Glu His Gly Phe 2135 2140 2145 Arg Arg Thr Thr
Pro Pro Thr Thr Ala Thr Pro Ile Arg His Arg 2150 2155 2160 Pro Arg
Pro Tyr Pro Pro Asn Val Gly Glu Glu Ile Gln Ile Gly 2165 2170 2175
His Ile Pro Arg Glu Asp Val Asp Tyr His Leu Tyr Pro His Gly 2180
2185 2190 Pro Gly Leu Asn Pro Asn Ala Ser Thr Gly Gln Glu Ala Leu
Ser 2195 2200 2205 Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln Asp Thr
Ser Glu Tyr 2210 2215 2220 Ile Ile Ser Cys His Pro Val Gly Thr Asp
Glu Glu Pro Leu Gln 2225 2230 2235 Phe Arg Val Pro Gly Thr Ser Thr
Ser Ala Thr Leu Thr Gly Leu 2240 2245 2250 Thr Arg Gly Ala Thr Tyr
Asn Ile Ile Val Glu Ala Leu Lys Asp 2255 2260 2265 Gln Gln Arg His
Lys Val Arg Glu Glu Val Val Thr Val Gly Asn 2270 2275 2280 Ser Val
Asn Glu Gly Leu Asn Gln Pro Thr Asp Asp Ser Cys Phe 2285 2290 2295
Asp Pro Tyr Thr Val Ser His Tyr Ala Val Gly Asp Glu Trp Glu 2300
2305 2310 Arg Met Ser Glu Ser Gly Phe Lys Leu Leu Cys Gln Cys Leu
Gly 2315 2320 2325 Phe Gly Ser Gly His Phe Arg Cys Asp Ser Ser Arg
Trp Cys His 2330 2335 2340 Asp Asn Gly Val Asn Tyr Lys Ile Gly Glu
Lys Trp Asp Arg Gln 2345 2350 2355 Gly Glu Asn Gly Gln Met Met Ser
Cys Thr Cys Leu Gly Asn Gly 2360 2365 2370 Lys Gly Glu Phe Lys Cys
Asp Pro His Glu Ala Thr Cys Tyr Asp 2375 2380 2385 Asp Gly Lys Thr
Tyr His Val Gly Glu Gln Trp Gln Lys Glu Tyr 2390 2395 2400 Leu Gly
Ala Ile Cys Ser Cys Thr Cys Phe Gly Gly Gln Arg Gly 2405 2410 2415
Trp Arg Cys Asp Asn Cys Arg Arg Pro Gly Gly Glu Pro Ser Pro 2420
2425 2430 Glu Gly Thr Thr Gly Gln Ser Tyr Asn Gln Tyr Ser Gln Arg
Tyr 2435 2440 2445 His Gln Arg Thr Asn Thr Asn Val Asn Cys Pro Ile
Glu Cys Phe 2450 2455 2460 Met Pro Leu Asp Val Gln Ala Asp Arg Glu
Asp Ser Arg Glu 2465 2470 2475 307782PRTHomo sapiens 307Met Ala Pro
His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 1 5 10 15 Ala
Leu Cys Ala Leu Ser Leu Pro Val Arg Ala Ala Thr Ala Ser Arg 20 25
30 Gly Ala Ser Gln Ala Gly Ala Pro Gln Gly Arg Val Pro Glu Ala Arg
35 40 45 Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala
Gly Lys 50 55 60 Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe
Asp Leu Val Pro 65 70 75 80 Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe
Thr Gly Asp Ala Tyr Val 85 90 95 Ile Leu Lys Thr Val Gln Leu Arg
Asn Gly Asn Leu Gln Tyr Asp Leu 100 105 110 His Tyr Trp Leu Gly Asn
Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala 115 120 125 Ala Ile Phe Thr
Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val 130 135 140 Gln His
Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr 145 150 155
160 Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe
165 170 175 Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe
Gln Val 180 185 190 Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro
Val Ser Trp Glu 195 200 205 Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu
Asp Leu Gly Asn Asn Ile 210 215 220 His Gln Trp Cys Gly Ser Asn Ser
Asn Arg Tyr Glu Arg Leu Lys Ala 225 230 235 240 Thr Gln Val Ser Lys
Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala 245 250 255 Arg Val His
Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln 260 265 270 Val
Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala 275 280
285 Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser
290 295 300 Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu
Asn Pro 305 310 315 320 Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys
Phe Ile Leu Asp His 325 330 335 Gly Lys Asp Gly Lys Ile Phe Val Trp
Lys Gly Lys Gln Ala Asn Thr 340 345 350 Glu Glu Arg Lys Ala Ala Leu
Lys Thr Ala Ser Asp Phe Ile Thr Lys 355 360 365 Met Asp Tyr Pro Lys
Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly 370 375 380 Glu Thr Pro
Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp 385 390 395 400
Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn 405
410 415 Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr
Ala 420 425 430 Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly
Gln Lys Gln 435 440 445 Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro
Val Asp Pro Ala Thr 450 455 460 Tyr Gly Gln Phe Tyr Gly Gly Asp Ser
Tyr Ile Ile Leu Tyr Asn Tyr 465 470 475 480 Arg His Gly Gly Arg Gln
Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala 485 490 495 Gln Ser Thr Gln
Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln 500 505 510 Leu Asp
Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln 515 520 525
Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met 530
535 540 Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala
Pro 545 550 555 560 Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser
Ala Gly Ala Thr 565 570 575 Arg Ala Val Glu Val Leu Pro Lys Ala Gly
Ala Leu Asn Ser Asn Asp 580 585 590 Ala Phe Val Leu Lys Thr Pro Ser
Ala Ala Tyr Leu Trp Val Gly Thr 595 600 605 Gly Ala Ser Glu Ala Glu
Lys Thr Gly Ala Gln Glu Leu Leu Arg Val 610 615 620 Leu Arg Ala Gln
Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly 625 630 635 640 Phe
Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg 645 650
655 Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys
660 665 670 Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly
Glu Leu 675 680 685 Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu
Leu Asp Thr Trp 690 695 700 Asp Gln Val Phe Val Trp Val Gly Lys Asp
Ser Gln Glu Glu Glu Lys 705 710 715 720 Thr Glu Ala Leu Thr Ser Ala
Lys Arg Tyr Ile Glu Thr Asp Pro Ala 725 730 735 Asn Arg Asp Arg Arg
Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu 740 745 750 Pro Pro Ser
Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp 755 760 765 Ser
Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala 770 775 780
308462PRTHomo sapiens 308Met Ala Arg Val Leu Gly Ala Pro Val Ala
Leu Gly Leu Trp Ser Leu 1 5 10 15 Cys Trp Ser Leu Ala Ile Ala Thr
Pro Leu Pro Pro Thr Ser Ala His 20 25 30 Gly Asn Val Ala Glu Gly
Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 35 40 45 Arg Cys Ser Asp
Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn 50 55 60 Gly Thr
Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys 65 70 75 80
Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro 85
90 95 Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile
Lys 100 105 110 Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu
Lys Gly Tyr 115 120 125 Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile
Pro Ser Pro Leu Asp 130 135 140 Ala Ala Val Glu Cys His Arg Gly Glu
Cys Gln Ala Glu Gly Val Leu 145 150 155 160 Phe Phe Gln Gly Asp Arg
Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 165 170 175 Met Lys Glu Arg
Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 180 185 190 Arg Trp
Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 195 200 205
Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 210
215 220 Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg
Asn 225 230 235 240 Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro
Glu Tyr Met Arg 245 250 255 Cys Ser Pro His Leu Val Leu Ser Ala Leu
Thr Ser Asp Asn His Gly 260 265 270 Ala Thr Tyr Ala Phe Ser Gly Thr
His Tyr Trp Arg Leu Asp Thr Ser 275 280 285 Arg Asp Gly Trp His Ser
Trp Pro Ile Ala His Gln Trp Pro Gln Gly 290 295 300 Pro Ser Ala Val
Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu 305 310 315 320 Val
Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr 325 330
335 Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro
340 345 350 His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys
Pro Gly 355 360 365 Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu
Trp Trp Leu Asp 370 375 380 Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr
Glu Leu Pro Trp Pro His 385 390 395 400 Glu Lys Val Asp Gly Ala Leu
Cys Met Glu Lys Ser Leu Gly Pro Asn 405 410 415 Ser Cys Ser Ala Asn
Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn 420 425 430 Leu Tyr Cys
Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu 435 440 445 Pro
Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His 450 455 460
309499PRTHomo sapiens 309Met Lys His Ser Leu Asn Ala Leu Leu Ile
Phe Leu Ile Ile Thr Ser 1 5 10 15 Ala Trp Gly Gly Ser Lys Gly Pro
Leu Asp Gln Leu Glu Lys Gly Gly 20 25 30 Glu Thr Ala Gln Ser Ala
Asp Pro Gln Trp Glu Gln Leu Asn Asn Lys 35 40 45 Asn Leu Ser Met
Pro Leu Leu Pro Ala Asp Phe His Lys Glu Asn Thr 50 55 60 Val Thr
Asn Asp Trp Ile Pro Glu Gly Glu Glu Asp Asp Asp Tyr Leu 65 70 75 80
Asp Leu Glu Lys Ile Phe Ser Glu Asp Asp Asp Tyr Ile Asp Ile Val 85
90 95 Asp Ser Leu Ser Val Ser Pro Thr Asp Ser Asp Val Ser Ala Gly
Asn 100 105 110 Ile Leu Gln Leu Phe His Gly Lys Ser Arg Ile Gln Arg
Leu Asn Ile 115 120 125 Leu Asn Ala Lys Phe Ala Phe Asn Leu Tyr Arg
Val Leu Lys Asp Gln 130 135 140
Val Asn Thr Phe Asp Asn Ile Phe Ile Ala Pro Val Gly Ile Ser Thr 145
150 155 160 Ala Met Gly Met Ile Ser Leu Gly Leu Lys Gly Glu Thr His
Glu Gln 165 170 175 Val His Ser Ile Leu His Phe Lys Asp Phe Val Asn
Ala Ser Ser Lys 180 185 190 Tyr Glu Ile Thr Thr Ile His Asn Leu Phe
Arg Lys Leu Thr His Arg 195 200 205 Leu Phe Arg Arg Asn Phe Gly Tyr
Thr Leu Arg Ser Val Asn Asp Leu 210 215 220 Tyr Ile Gln Lys Gln Phe
Pro Ile Leu Leu Asp Phe Arg Thr Lys Val 225 230 235 240 Arg Glu Tyr
Tyr Phe Ala Glu Ala Gln Ile Ala Asp Phe Ser Asp Pro 245 250 255 Ala
Phe Ile Ser Lys Thr Asn Asn His Ile Met Lys Leu Thr Lys Gly 260 265
270 Leu Ile Lys Asp Ala Leu Glu Asn Ile Asp Pro Ala Thr Gln Met Met
275 280 285 Ile Leu Asn Cys Ile Tyr Phe Lys Gly Ser Trp Val Asn Lys
Phe Pro 290 295 300 Val Glu Met Thr His Asn His Asn Phe Arg Leu Asn
Glu Arg Glu Val 305 310 315 320 Val Lys Val Ser Met Met Gln Thr Lys
Gly Asn Phe Leu Ala Ala Asn 325 330 335 Asp Gln Glu Leu Asp Cys Asp
Ile Leu Gln Leu Glu Tyr Val Gly Gly 340 345 350 Ile Ser Met Leu Ile
Val Val Pro His Lys Met Ser Gly Met Lys Thr 355 360 365 Leu Glu Ala
Gln Leu Thr Pro Arg Val Val Glu Arg Trp Gln Lys Ser 370 375 380 Met
Thr Asn Arg Thr Arg Glu Val Leu Leu Pro Lys Phe Lys Leu Glu 385 390
395 400 Lys Asn Tyr Asn Leu Val Glu Ser Leu Lys Leu Met Gly Ile Arg
Met 405 410 415 Leu Phe Asp Lys Asn Gly Asn Met Ala Gly Ile Ser Asp
Gln Arg Ile 420 425 430 Ala Ile Asp Leu Phe Lys His Gln Gly Thr Ile
Thr Val Asn Glu Glu 435 440 445 Gly Thr Gln Ala Thr Thr Val Thr Thr
Val Gly Phe Met Pro Leu Ser 450 455 460 Thr Gln Val Arg Phe Thr Val
Asp Arg Pro Phe Leu Phe Leu Ile Tyr 465 470 475 480 Glu His Arg Thr
Ser Cys Leu Leu Phe Met Gly Arg Val Ala Asn Pro 485 490 495 Ser Arg
Ser 310583PRTHomo sapiens 310Met Lys Leu Leu His Val Phe Leu Leu
Phe Leu Cys Phe His Leu Arg 1 5 10 15 Phe Cys Lys Val Thr Tyr Thr
Ser Gln Glu Asp Leu Val Glu Lys Lys 20 25 30 Cys Leu Ala Lys Lys
Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 35 40 45 Gln Pro Trp
Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 50 55 60 Tyr
Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 65 70
75 80 Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His
Pro 85 90 95 Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu
Gly Lys Phe 100 105 110 Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser
Glu Gly Ile Val Glu 115 120 125 Val Lys Leu Val Asp Gln Asp Lys Thr
Met Phe Ile Cys Lys Ser Ser 130 135 140 Trp Ser Met Arg Glu Ala Asn
Val Ala Cys Leu Asp Leu Gly Phe Gln 145 150 155 160 Gln Gly Ala Asp
Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 165 170 175 Asn Ser
Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 180 185 190
Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 195
200 205 Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met
Asp 210 215 220 Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln
Met Lys Ala 225 230 235 240 Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln
Ser Asp Glu Leu Cys Cys 245 250 255 Lys Ala Cys Gln Gly Lys Gly Phe
His Cys Lys Ser Gly Val Cys Ile 260 265 270 Pro Ser Gln Tyr Gln Cys
Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 275 280 285 Asp Glu Val Gly
Cys Ala Gly Phe Ala Ser Val Ala Gln Glu Glu Thr 290 295 300 Glu Ile
Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 305 310 315
320 Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg
325 330 335 Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp
Leu Pro 340 345 350 Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr
Cys Gly Gly Ile 355 360 365 Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala
Ala His Cys Leu Arg Ala 370 375 380 Ser Lys Thr His Arg Tyr Gln Ile
Trp Thr Thr Val Val Asp Trp Ile 385 390 395 400 His Pro Asp Leu Lys
Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 405 410 415 Phe His Glu
Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 420 425 430 Ile
Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 435 440
445 Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn
450 455 460 Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn
Glu Arg 465 470 475 480 Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu
Ile Ser Asn Cys Ser 485 490 495 Lys Phe Tyr Gly Asn Arg Phe Tyr Glu
Lys Glu Met Glu Cys Ala Gly 500 505 510 Thr Tyr Asp Gly Ser Ile Asp
Ala Cys Lys Gly Asp Ser Gly Gly Pro 515 520 525 Leu Val Cys Met Asp
Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 530 535 540 Ser Trp Gly
Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Phe Tyr Thr 545 550 555 560
Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 565
570 575 Phe Ile Ser Gln Tyr Asn Val 580 311159PRTHomo sapiens
311Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys
1 5 10 15 Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu
Val Asp 20 25 30 Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile
Ile Arg Ser Ser 35 40 45 Glu Asp Pro Asn Glu Asp Ile Val Glu Arg
Asn Ile Arg Ile Ile Val 50 55 60 Pro Leu Asn Asn Arg Glu Asn Ile
Ser Asp Pro Thr Ser Pro Leu Arg 65 70 75 80 Thr Arg Phe Val Tyr His
Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro 85 90 95 Thr Glu Val Glu
Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn 100 105 110 Ile Cys
Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg 115 120 125
Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr 130
135 140 Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp
145 150 155 312911PRTHomo sapiens 312Met Asp Gly Ala Met Gly Pro
Arg Gly Leu Leu Leu Cys Met Tyr Leu 1 5 10 15 Val Ser Leu Leu Ile
Leu Gln Ala Met Pro Ala Leu Gly Ser Ala Thr 20 25 30 Gly Arg Ser
Lys Ser Ser Glu Lys Arg Gln Ala Val Asp Thr Ala Val 35 40 45 Asp
Gly Val Phe Ile Arg Ser Leu Lys Val Asn Cys Lys Val Thr Ser 50 55
60 Arg Phe Ala His Tyr Val Val Thr Ser Gln Val Val Asn Thr Ala Asn
65 70 75 80 Glu Ala Arg Glu Val Ala Phe Asp Leu Glu Ile Pro Lys Thr
Ala Phe 85 90 95 Ile Ser Asp Phe Ala Val Thr Ala Asp Gly Asn Ala
Phe Ile Gly Asp 100 105 110 Ile Lys Asp Lys Val Thr Ala Trp Lys Gln
Tyr Arg Lys Ala Ala Ile 115 120 125 Ser Gly Glu Asn Ala Gly Leu Val
Arg Ala Ser Gly Arg Thr Met Glu 130 135 140 Gln Phe Thr Ile His Leu
Thr Val Asn Pro Gln Ser Lys Val Thr Phe 145 150 155 160 Gln Leu Thr
Tyr Glu Glu Val Leu Lys Arg Asn His Met Gln Tyr Glu 165 170 175 Ile
Val Ile Lys Val Lys Pro Lys Gln Leu Val His His Phe Glu Ile 180 185
190 Asp Val Asp Ile Phe Glu Pro Gln Gly Ile Ser Lys Leu Asp Ala Gln
195 200 205 Ala Ser Phe Leu Pro Lys Glu Leu Ala Ala Gln Thr Ile Lys
Lys Ser 210 215 220 Phe Ser Gly Lys Lys Gly His Val Leu Phe Arg Pro
Thr Val Ser Gln 225 230 235 240 Gln Gln Ser Cys Pro Thr Cys Ser Thr
Ser Leu Leu Asn Gly His Phe 245 250 255 Lys Val Thr Tyr Asp Val Thr
Arg Asp Glu Ile Cys Asp Leu Leu Val 260 265 270 Ala Asn Asn His Phe
Ala His Phe Phe Ala Pro Gln Asn Leu Thr Asn 275 280 285 Met Asn Lys
Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser Met Arg 290 295 300 Gly
Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile Leu Gly 305 310
315 320 Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly Thr
Arg 325 330 335 Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu
Ala Asn Leu 340 345 350 Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser
Leu Asp Glu Ala Thr 355 360 365 Asn Leu Asn Gly Gly Leu Leu Arg Gly
Ile Glu Ile Leu Asn Gln Val 370 375 380 Gln Glu Ser Leu Pro Glu Leu
Ser Asn His Ala Ser Ile Leu Ile Met 385 390 395 400 Leu Thr Asp Gly
Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln Ile 405 410 415 Leu Lys
Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr Asn 420 425 430
Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met Ser 435
440 445 Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp
Ala 450 455 460 Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys
Pro Leu Leu 465 470 475 480 Val Asp Val Asp Leu Gln Tyr Pro Gln Asp
Ala Val Leu Ala Leu Thr 485 490 495 Gln Asn His His Lys Gln Tyr Tyr
Glu Gly Ser Glu Ile Val Val Ala 500 505 510 Gly Arg Ile Ala Asp Asn
Lys Gln Ser Ser Phe Lys Ala Asp Val Gln 515 520 525 Ala His Gly Glu
Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp Glu 530 535 540 Glu Glu
Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu Asn 545 550 555
560 His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu Ala
565 570 575 Lys Arg Met Lys Val Asp Arg Glu Val Arg Ala Asn Leu Ser
Ser Gln 580 585 590 Ala Leu Arg Met Ser Leu Asp Tyr Gly Phe Val Thr
Pro Leu Thr Ser 595 600 605 Met Ser Ile Arg Gly Met Ala Asp Gln Asp
Gly Leu Lys Pro Thr Ile 610 615 620 Asp Lys Pro Ser Glu Asp Ser Pro
Pro Leu Glu Met Leu Gly Pro Arg 625 630 635 640 Arg Thr Phe Val Leu
Ser Ala Leu Gln Pro Ser Pro Thr His Ser Ser 645 650 655 Ser Asn Thr
Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr Asp 660 665 670 Pro
His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys Phe 675 680
685 Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp Pro
690 695 700 Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys
Ala Arg 705 710 715 720 Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly
Arg Leu Gly Ile Ala 725 730 735 Asn Pro Ala Thr Asp Phe Gln Leu Glu
Val Thr Pro Gln Asn Ile Thr 740 745 750 Leu Asn Pro Gly Phe Gly Gly
Pro Val Phe Ser Trp Arg Asp Gln Ala 755 760 765 Val Leu Arg Gln Asp
Gly Val Val Val Thr Ile Asn Lys Lys Arg Asn 770 775 780 Leu Val Val
Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu His 785 790 795 800
Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe Tyr 805
810 815 Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu
Gly 820 825 830 Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile
His Pro Gly 835 840 845 Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val
Val Arg Asn Arg Arg 850 855 860 Leu Thr Val Thr Arg Gly Leu Gln Lys
Asp Tyr Ser Lys Asp Pro Trp 865 870 875 880 His Gly Ala Glu Val Ser
Cys Trp Phe Ile His Asn Asn Gly Ala Gly 885 890 895 Leu Ile Asp Gly
Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe 900 905 910
313946PRTHomo sapiens 313Met Lys Arg Leu Thr Cys Phe Phe Ile Cys
Phe Phe Leu Ser Glu Val 1 5 10 15 Ser Gly Phe Glu Ile Pro Ile Asn
Gly Leu Ser Glu Phe Val Asp Tyr 20 25 30 Glu Asp Leu Val Glu Leu
Ala Pro Gly Lys Phe Gln Leu Val Ala Glu 35 40 45 Asn Arg Arg Tyr
Gln Arg Ser Leu Pro Gly Glu Ser Glu Glu Met Met 50 55 60 Glu Glu
Val Asp Gln Val Thr Leu Tyr Ser Tyr Lys Val Gln Ser Thr 65 70 75 80
Ile Thr Ser Arg Met Ala Thr Thr Met Ile Gln Ser Lys Val Val Asn 85
90 95 Asn Ser Pro Gln Pro Gln Asn Val Val Phe Asp Val Gln Ile Pro
Lys 100 105 110 Gly Ala Phe Ile Ser Asn Phe Ser Met Thr Val Asp Gly
Lys Thr Phe 115 120 125 Arg Ser Ser Ile Lys Glu Lys Thr Val Gly Arg
Ala Leu Tyr Ala Gln 130 135 140 Ala Arg Ala Lys Gly Lys Thr Ala Gly
Leu Val Arg Ser Ser Ala Leu 145 150 155 160 Asp Met Glu Asn Phe Arg
Thr Glu Val Asn Val Leu Pro Gly Ala Lys 165 170 175 Val Gln Phe Glu
Leu His Tyr Gln Glu Val Lys Trp Arg Lys Leu Gly 180 185 190 Ser Tyr
Glu His Arg Ile Tyr Leu Gln Pro Gly Arg Leu Ala Lys His 195 200 205
Leu Glu Val Asp Val Trp Val Ile Glu Pro Gln Gly Leu Arg Phe Leu 210
215 220 His Val Pro Asp Thr Phe Glu Gly His Phe Asp Gly Val Pro Val
Ile 225 230 235 240 Ser Lys Gly Gln Gln Lys Ala His Val Ser Phe Lys
Pro Thr Val Ala 245 250 255 Gln Gln Arg Ile Cys Pro Ser Cys Arg Glu
Thr Ala Val Asp Gly Glu 260 265 270 Leu Val Val Leu Tyr Asp Val Lys
Arg Glu Glu Lys Ala Gly Glu Leu 275 280 285 Glu Val Phe Asn
Gly Tyr Phe Val His Phe Phe Ala Pro Asp Asn Leu 290 295 300 Asp Pro
Ile Pro Lys Asn Ile Leu Phe Val Ile Asp Val Ser Gly Ser 305 310 315
320 Met Trp Gly Val Lys Met Lys Gln Thr Val Glu Ala Met Lys Thr Ile
325 330 335 Leu Asp Asp Leu Arg Ala Glu Asp His Phe Ser Val Ile Asp
Phe Asn 340 345 350 Gln Asn Ile Arg Thr Trp Arg Asn Asp Leu Phe Gln
Leu Gln Lys His 355 360 365 Arg Leu Gln Ile Ala Lys Arg Tyr Ile Glu
Lys Ile Gln Pro Ser Gly 370 375 380 Gly Thr Asn Ile Asn Glu Ala Leu
Leu Arg Ala Ile Phe Ile Leu Asn 385 390 395 400 Glu Ala Asn Asn Leu
Gly Leu Leu Asp Pro Asn Ser Val Ser Leu Ile 405 410 415 Ile Leu Val
Ser Asp Gly Asp Pro Thr Val Gly Glu Leu Lys Leu Ser 420 425 430 Lys
Ile Gln Lys Asn Val Lys Glu Asn Ile Gln Asp Asn Ile Ser Leu 435 440
445 Phe Ser Leu Gly Met Gly Phe Asp Val Asp Tyr Asp Phe Leu Lys Arg
450 455 460 Leu Ser Asn Glu Asn His Gly Ile Ala Gln Arg Ile Tyr Gly
Asn Gln 465 470 475 480 Asp Thr Ser Ser Gln Leu Lys Lys Phe Tyr Asn
Gln Val Ser Thr Pro 485 490 495 Leu Leu Arg Asn Val Gln Phe Asn Tyr
Pro His Thr Ser Val Thr Asp 500 505 510 Val Thr Gln Asn Asn Phe His
Asn Tyr Phe Gly Gly Ser Glu Ile Val 515 520 525 Val Ala Gly Lys Phe
Asp Pro Ala Lys Leu Asp Gln Ile Glu Ser Val 530 535 540 Ile Thr Ala
Thr Ser Ala Asn Thr Gln Leu Val Leu Glu Thr Leu Ala 545 550 555 560
Gln Met Asp Asp Leu Gln Asp Phe Leu Ser Lys Asp Lys His Ala Asp 565
570 575 Pro Asp Phe Thr Arg Lys Leu Trp Ala Tyr Leu Thr Ile Asn Gln
Leu 580 585 590 Leu Ala Glu Arg Ser Leu Ala Pro Thr Ala Ala Ala Lys
Arg Arg Ile 595 600 605 Thr Arg Ser Ile Leu Gln Met Ser Leu Asp His
His Ile Val Thr Pro 610 615 620 Leu Thr Ser Leu Val Ile Glu Asn Glu
Ala Gly Asp Glu Arg Met Leu 625 630 635 640 Ala Asp Ala Pro Pro Gln
Asp Pro Ser Cys Cys Ser Gly Ala Leu Tyr 645 650 655 Tyr Gly Ser Lys
Val Val Pro Asp Ser Thr Pro Ser Trp Ala Asn Pro 660 665 670 Ser Pro
Thr Pro Val Ile Ser Met Leu Ala Gln Gly Ser Gln Val Leu 675 680 685
Glu Ser Thr Pro Pro Pro His Val Met Arg Val Glu Asn Asp Pro His 690
695 700 Phe Ile Ile Tyr Leu Pro Lys Ser Gln Lys Asn Ile Cys Phe Asn
Ile 705 710 715 720 Asp Ser Glu Pro Gly Lys Ile Leu Asn Leu Val Ser
Asp Pro Glu Ser 725 730 735 Gly Ile Val Val Asn Gly Gln Leu Val Gly
Ala Lys Lys Pro Asn Asn 740 745 750 Gly Lys Leu Ser Thr Tyr Phe Gly
Lys Leu Gly Phe Tyr Phe Gln Ser 755 760 765 Glu Asp Ile Lys Ile Glu
Ile Ser Thr Glu Thr Ile Thr Leu Ser His 770 775 780 Gly Ser Ser Thr
Phe Ser Leu Ser Trp Ser Asp Thr Ala Gln Val Thr 785 790 795 800 Asn
Gln Arg Val Gln Ile Ser Val Lys Lys Glu Lys Val Val Thr Ile 805 810
815 Thr Leu Asp Lys Glu Met Ser Phe Ser Val Leu Leu His Arg Val Trp
820 825 830 Lys Lys His Pro Val Asn Val Asp Phe Leu Gly Ile Tyr Ile
Pro Pro 835 840 845 Thr Asn Lys Phe Ser Pro Lys Ala His Gly Leu Ile
Gly Gln Phe Met 850 855 860 Gln Glu Pro Lys Ile His Ile Phe Asn Glu
Arg Pro Gly Lys Asp Pro 865 870 875 880 Glu Lys Pro Glu Ala Ser Met
Glu Val Lys Gly Gln Lys Leu Ile Ile 885 890 895 Thr Arg Gly Leu Gln
Lys Asp Tyr Arg Thr Asp Leu Val Phe Gly Thr 900 905 910 Asp Val Thr
Cys Trp Phe Val His Asn Ser Gly Lys Gly Phe Ile Asp 915 920 925 Gly
His Tyr Lys Asp Tyr Phe Val Pro Gln Leu Tyr Ser Phe Leu Lys 930 935
940 Arg Pro 945 314885PRTHomo sapiens 314Met Val Ala Leu Ser His
Leu Gly Ser Ala Leu Gln Leu Gly Ser Leu 1 5 10 15 Cys Phe Pro Arg
Ser Pro Phe Arg Leu Leu Gly Lys Arg Ser Leu Pro 20 25 30 Glu Gly
Val Ala Asn Gly Ile Glu Val Tyr Ser Thr Lys Ile Asn Ser 35 40 45
Lys Val Thr Ser Arg Phe Ala His Asn Val Val Thr Met Arg Ala Val 50
55 60 Asn Arg Ala Asp Thr Ala Lys Glu Val Ser Phe Asp Val Glu Leu
Pro 65 70 75 80 Lys Thr Ala Phe Ile Thr Asn Phe Thr Leu Thr Ile Asp
Gly Val Thr 85 90 95 Tyr Pro Gly Asn Val Lys Glu Lys Glu Val Ala
Lys Lys Gln Tyr Glu 100 105 110 Lys Ala Val Ser Gln Gly Lys Thr Ala
Gly Leu Val Lys Ala Ser Gly 115 120 125 Arg Lys Leu Glu Lys Phe Thr
Val Ser Val Asn Val Ala Ala Gly Ser 130 135 140 Lys Val Thr Phe Glu
Leu Thr Tyr Glu Glu Leu Leu Lys Arg His Lys 145 150 155 160 Gly Lys
Tyr Glu Met Tyr Leu Lys Val Gln Pro Lys Gln Leu Val Lys 165 170 175
His Phe Glu Ile Glu Val Asp Ile Phe Glu Pro Gln Gly Ile Ser Met 180
185 190 Leu Asp Ala Glu Ala Ser Phe Ile Thr Asn Asp Leu Leu Gly Ser
Ala 195 200 205 Leu Thr Lys Ser Phe Ser Gly Lys Lys Gly His Val Ser
Phe Lys Pro 210 215 220 Ser Leu Asp Gln Gln Arg Ser Cys Pro Thr Cys
Thr Asp Ser Leu Leu 225 230 235 240 Asn Gly Asp Phe Thr Ile Thr Tyr
Asp Val Asn Arg Glu Ser Pro Gly 245 250 255 Asn Val Gln Ile Val Asn
Gly Tyr Phe Val His Phe Phe Ala Pro Gln 260 265 270 Gly Leu Pro Val
Val Pro Lys Asn Val Ala Phe Val Ile Asp Ile Ser 275 280 285 Gly Ser
Met Ala Gly Arg Lys Leu Glu Gln Thr Lys Glu Ala Leu Leu 290 295 300
Arg Ile Leu Glu Asp Met Lys Glu Glu Asp Tyr Leu Asn Phe Ile Leu 305
310 315 320 Phe Ser Gly Asp Val Ser Thr Trp Lys Glu His Leu Val Gln
Ala Thr 325 330 335 Pro Glu Asn Leu Gln Glu Ala Arg Thr Phe Val Lys
Ser Met Glu Asp 340 345 350 Lys Gly Met Thr Asn Ile Asn Asp Gly Leu
Leu Arg Gly Ile Ser Met 355 360 365 Leu Asn Lys Ala Arg Glu Glu His
Arg Ile Pro Glu Arg Ser Thr Ser 370 375 380 Ile Val Ile Met Leu Thr
Asp Gly Asp Ala Asn Val Gly Glu Ser Arg 385 390 395 400 Pro Glu Lys
Ile Gln Glu Asn Val Arg Asn Ala Ile Gly Gly Lys Phe 405 410 415 Pro
Leu Tyr Asn Leu Gly Phe Gly Asn Asn Leu Asn Tyr Asn Phe Leu 420 425
430 Glu Asn Met Ala Leu Glu Asn His Gly Phe Ala Arg Arg Ile Tyr Glu
435 440 445 Asp Ser Asp Ala Asp Leu Gln Leu Gln Gly Phe Tyr Glu Glu
Val Ala 450 455 460 Asn Pro Leu Leu Thr Gly Val Glu Met Glu Tyr Pro
Glu Asn Ala Ile 465 470 475 480 Leu Asp Leu Thr Gln Asn Thr Tyr Gln
His Phe Tyr Asp Gly Ser Glu 485 490 495 Ile Val Val Ala Gly Arg Leu
Val Asp Glu Asp Met Asn Ser Phe Lys 500 505 510 Ala Asp Val Lys Gly
His Gly Ala Thr Asn Asp Leu Thr Phe Thr Glu 515 520 525 Glu Val Asp
Met Lys Glu Met Glu Lys Ala Leu Gln Glu Arg Asp Tyr 530 535 540 Ile
Phe Gly Asn Tyr Ile Glu Arg Leu Trp Ala Tyr Leu Thr Ile Glu 545 550
555 560 Gln Leu Leu Glu Lys Arg Lys Asn Ala His Gly Glu Glu Lys Glu
Asn 565 570 575 Leu Thr Ala Arg Ala Leu Asp Leu Ser Leu Lys Tyr His
Phe Val Thr 580 585 590 Pro Leu Thr Ser Met Val Val Thr Lys Pro Glu
Asp Asn Glu Asp Glu 595 600 605 Arg Ala Ile Ala Asp Lys Pro Gly Glu
Asp Ala Glu Ala Thr Pro Val 610 615 620 Ser Pro Ala Met Ser Tyr Leu
Thr Ser Tyr Gln Pro Pro Gln Asn Pro 625 630 635 640 Tyr Tyr Tyr Val
Asp Gly Asp Pro His Phe Ile Ile Gln Ile Pro Glu 645 650 655 Lys Asp
Asp Ala Leu Cys Phe Asn Ile Asp Glu Ala Pro Gly Thr Val 660 665 670
Leu Arg Leu Ile Gln Asp Ala Val Thr Gly Leu Thr Val Asn Gly Gln 675
680 685 Ile Thr Gly Asp Lys Arg Gly Ser Pro Asp Ser Lys Thr Arg Lys
Thr 690 695 700 Tyr Phe Gly Lys Leu Gly Ile Arg Asn Ala Gln Met Asp
Phe Gln Val 705 710 715 720 Glu Val Thr Thr Glu Lys Ile Thr Cys Gly
Thr Gly Arg Ala Ser Thr 725 730 735 Phe Ser Trp Leu Asp Thr Val Thr
Val Thr Gln Asp Gly Leu Ser Met 740 745 750 Met Ile Asn Arg Lys Asn
Met Val Val Ser Phe Gly Asp Gly Val Thr 755 760 765 Phe Val Val Val
Leu His Gln Val Trp Lys Lys His Pro Val His Arg 770 775 780 Asp Phe
Leu Gly Phe Tyr Val Val Asp Ser His Arg Met Ser Ala Gln 785 790 795
800 Thr His Gly Leu Leu Gly Gln Phe Phe Gln Pro Phe Asp Phe Lys Val
805 810 815 Ser Asp Ile Arg Pro Gly Ser Asp Pro Thr Lys Pro Asp Ala
Thr Leu 820 825 830 Val Val Lys Asn His Gln Leu Ile Val Thr Arg Gly
Ser Gln Lys Asp 835 840 845 Tyr Arg Lys Asp Ala Ser Ile Gly Thr Lys
Val Val Cys Trp Phe Val 850 855 860 His Asn Asn Gly Glu Gly Leu Ile
Asp Gly Val His Thr Asp Tyr Ile 865 870 875 880 Val Pro Asn Leu Phe
885 315930PRTHomo sapiens 315Met Lys Pro Pro Arg Pro Val Arg Thr
Cys Ser Lys Val Leu Val Leu 1 5 10 15 Leu Ser Leu Leu Ala Ile His
Gln Thr Thr Thr Ala Glu Lys Asn Gly 20 25 30 Ile Asp Ile Tyr Ser
Leu Thr Val Asp Ser Arg Val Ser Ser Arg Phe 35 40 45 Ala His Thr
Val Val Thr Ser Arg Val Val Asn Arg Ala Asn Thr Val 50 55 60 Gln
Glu Ala Thr Phe Gln Met Glu Leu Pro Lys Lys Ala Phe Ile Thr 65 70
75 80 Asn Phe Ser Met Ile Ile Asp Gly Met Thr Tyr Pro Gly Ile Ile
Lys 85 90 95 Glu Lys Ala Glu Ala Gln Ala Gln Tyr Ser Ala Ala Val
Ala Lys Gly 100 105 110 Lys Ser Ala Gly Leu Val Lys Ala Thr Gly Arg
Asn Met Glu Gln Phe 115 120 125 Gln Val Ser Val Ser Val Ala Pro Asn
Ala Lys Ile Thr Phe Glu Leu 130 135 140 Val Tyr Glu Glu Leu Leu Lys
Arg Arg Leu Gly Val Tyr Glu Leu Leu 145 150 155 160 Leu Lys Val Arg
Pro Gln Gln Leu Val Lys His Leu Gln Met Asp Ile 165 170 175 His Ile
Phe Glu Pro Gln Gly Ile Ser Phe Leu Glu Thr Glu Ser Thr 180 185 190
Phe Met Thr Asn Gln Leu Val Asp Ala Leu Thr Thr Trp Gln Asn Lys 195
200 205 Thr Lys Ala His Ile Arg Phe Lys Pro Thr Leu Ser Gln Gln Gln
Lys 210 215 220 Ser Pro Glu Gln Gln Glu Thr Val Leu Asp Gly Asn Leu
Ile Ile Arg 225 230 235 240 Tyr Asp Val Asp Arg Ala Ile Ser Gly Gly
Ser Ile Gln Ile Glu Asn 245 250 255 Gly Tyr Phe Val His Tyr Phe Ala
Pro Glu Gly Leu Thr Thr Met Pro 260 265 270 Lys Asn Val Val Phe Val
Ile Asp Lys Ser Gly Ser Met Ser Gly Arg 275 280 285 Lys Ile Gln Gln
Thr Arg Glu Ala Leu Ile Lys Ile Leu Asp Asp Leu 290 295 300 Ser Pro
Arg Asp Gln Phe Asn Leu Ile Val Phe Ser Thr Glu Ala Thr 305 310 315
320 Gln Trp Arg Pro Ser Leu Val Pro Ala Ser Ala Glu Asn Val Asn Lys
325 330 335 Ala Arg Ser Phe Ala Ala Gly Ile Gln Ala Leu Gly Gly Thr
Asn Ile 340 345 350 Asn Asp Ala Met Leu Met Ala Val Gln Leu Leu Asp
Ser Ser Asn Gln 355 360 365 Glu Glu Arg Leu Pro Glu Gly Ser Val Ser
Leu Ile Ile Leu Leu Thr 370 375 380 Asp Gly Asp Pro Thr Val Gly Glu
Thr Asn Pro Arg Ser Ile Gln Asn 385 390 395 400 Asn Val Arg Glu Ala
Val Ser Gly Arg Tyr Ser Leu Phe Cys Leu Gly 405 410 415 Phe Gly Phe
Asp Val Ser Tyr Ala Phe Leu Glu Lys Leu Ala Leu Asp 420 425 430 Asn
Gly Gly Leu Ala Arg Arg Ile His Glu Asp Ser Asp Ser Ala Leu 435 440
445 Gln Leu Gln Asp Phe Tyr Gln Glu Val Ala Asn Pro Leu Leu Thr Ala
450 455 460 Val Thr Phe Glu Tyr Pro Ser Asn Ala Val Glu Glu Val Thr
Gln Asn 465 470 475 480 Asn Phe Arg Leu Leu Phe Lys Gly Ser Glu Met
Val Val Ala Gly Lys 485 490 495 Leu Gln Asp Arg Gly Pro Asp Val Leu
Thr Ala Thr Val Ser Gly Lys 500 505 510 Leu Pro Thr Gln Asn Ile Thr
Phe Gln Thr Glu Ser Ser Val Ala Glu 515 520 525 Gln Glu Ala Glu Phe
Gln Ser Pro Lys Tyr Ile Phe His Asn Phe Met 530 535 540 Glu Arg Leu
Trp Ala Tyr Leu Thr Ile Gln Gln Leu Leu Glu Gln Thr 545 550 555 560
Val Ser Ala Ser Asp Ala Asp Gln Gln Ala Leu Arg Asn Gln Ala Leu 565
570 575 Asn Leu Ser Leu Ala Tyr Ser Phe Val Thr Pro Leu Thr Ser Met
Val 580 585 590 Val Thr Lys Pro Asp Asp Gln Glu Gln Ser Gln Val Ala
Glu Lys Pro 595 600 605 Met Glu Gly Glu Ser Arg Asn Arg Asn Val His
Ser Gly Ser Thr Phe 610 615 620 Phe Lys Tyr Tyr Leu Gln Gly Ala Lys
Ile Pro Lys Pro Glu Ala Ser 625 630 635 640 Phe Ser Pro Arg Arg Gly
Trp Asn Arg Gln Ala Gly Ala Ala Gly Ser 645 650 655 Arg Met Asn Phe
Arg Pro Gly Val Leu Ser Ser Arg Gln Leu Gly Leu 660 665 670 Pro Gly
Pro Pro Asp Val Pro Asp His Ala Ala Tyr His Pro Phe Arg 675 680 685
Arg Leu Ala Ile Leu Pro Ala Ser Ala Pro Pro Ala Thr Ser Asn Pro 690
695 700 Asp Pro Ala Val Ser Arg Val Met Asn Met Lys Ile Glu Glu Thr
Thr 705 710 715 720 Met Thr Thr Gln Thr Pro Ala Pro Ile Gln Ala Pro
Ser Ala Ile Leu 725 730 735 Pro Leu Pro Gly Gln Ser Val Glu Arg Leu
Cys Val Asp Pro Arg His 740 745 750 Arg Gln Gly Pro Val Asn Leu Leu
Ser Asp Pro Glu Gln Gly Val Glu
755 760 765 Val Thr Gly Gln Tyr Glu Arg Glu Lys Ala Gly Phe Ser Trp
Ile Glu 770 775 780 Val Thr Phe Lys Asn Pro Leu Val Trp Val His Ala
Ser Pro Glu His 785 790 795 800 Val Val Val Thr Arg Asn Arg Arg Ser
Ser Ala Tyr Lys Trp Lys Glu 805 810 815 Thr Leu Phe Ser Val Met Pro
Gly Leu Lys Met Thr Met Asp Lys Thr 820 825 830 Gly Leu Leu Leu Leu
Ser Asp Pro Asp Lys Val Thr Ile Gly Leu Leu 835 840 845 Phe Trp Asp
Gly Arg Gly Glu Gly Leu Arg Leu Leu Leu Arg Asp Thr 850 855 860 Asp
Arg Phe Ser Ser His Val Gly Gly Thr Leu Gly Gln Phe Tyr Gln 865 870
875 880 Glu Val Leu Trp Gly Ser Pro Ala Ala Ser Asp Asp Gly Arg Arg
Thr 885 890 895 Leu Arg Val Gln Gly Asn Asp His Ser Ala Thr Arg Glu
Arg Arg Leu 900 905 910 Asp Tyr Gln Glu Gly Pro Pro Gly Val Glu Ile
Ser Cys Trp Ser Val 915 920 925 Glu Leu 930 316178PRTHomo sapiens
316Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val
1 5 10 15 Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys
Thr His 20 25 30 Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu
Arg Asp Ala Phe 35 40 45 Ser Arg Val Lys Thr Phe Phe Gln Met Lys
Asp Gln Leu Asp Asn Leu 50 55 60 Leu Leu Lys Glu Ser Leu Leu Glu
Asp Phe Lys Gly Tyr Leu Gly Cys 65 70 75 80 Gln Ala Leu Ser Glu Met
Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 85 90 95 Gln Ala Glu Asn
Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 100 105 110 Gly Glu
Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 115 120 125
Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 130
135 140 Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser
Glu 145 150 155 160 Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met
Thr Met Lys Ile 165 170 175 Arg Asn 317427PRTHomo sapiens 317Met
Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 1 5 10
15 Leu Thr Gln Glu Ser Gln Ser Glu Glu Ile Asp Cys Asn Asp Lys Asp
20 25 30 Leu Phe Lys Ala Val Asp Ala Ala Leu Lys Lys Tyr Asn Ser
Gln Asn 35 40 45 Gln Ser Asn Asn Gln Phe Val Leu Tyr Arg Ile Thr
Glu Ala Thr Lys 50 55 60 Thr Val Gly Ser Asp Thr Phe Tyr Ser Phe
Lys Tyr Glu Ile Lys Glu 65 70 75 80 Gly Asp Cys Pro Val Gln Ser Gly
Lys Thr Trp Gln Asp Cys Glu Tyr 85 90 95 Lys Asp Ala Ala Lys Ala
Ala Thr Gly Glu Cys Thr Ala Thr Val Gly 100 105 110 Lys Arg Ser Ser
Thr Lys Phe Ser Val Ala Thr Gln Thr Cys Gln Ile 115 120 125 Thr Pro
Ala Glu Gly Pro Val Val Thr Ala Gln Tyr Asp Cys Leu Gly 130 135 140
Cys Val His Pro Ile Ser Thr Gln Ser Pro Asp Leu Glu Pro Ile Leu 145
150 155 160 Arg His Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser
Ser Leu 165 170 175 Phe Met Leu Asn Glu Val Lys Arg Ala Gln Arg Gln
Val Val Ala Gly 180 185 190 Leu Asn Phe Arg Ile Thr Tyr Ser Ile Val
Gln Thr Asn Cys Ser Lys 195 200 205 Glu Asn Phe Leu Phe Leu Thr Pro
Asp Cys Lys Ser Leu Trp Asn Gly 210 215 220 Asp Thr Gly Glu Cys Thr
Asp Asn Ala Tyr Ile Asp Ile Gln Leu Arg 225 230 235 240 Ile Ala Ser
Phe Ser Gln Asn Cys Asp Ile Tyr Pro Gly Lys Asp Phe 245 250 255 Val
Gln Pro Pro Thr Lys Ile Cys Val Gly Cys Pro Arg Asp Ile Pro 260 265
270 Thr Asn Ser Pro Glu Leu Glu Glu Thr Leu Thr His Thr Ile Thr Lys
275 280 285 Leu Asn Ala Glu Asn Asn Ala Thr Phe Tyr Phe Lys Ile Asp
Asn Val 290 295 300 Lys Lys Ala Arg Val Gln Val Val Ala Gly Lys Lys
Tyr Phe Ile Asp 305 310 315 320 Phe Val Ala Arg Glu Thr Thr Cys Ser
Lys Glu Ser Asn Glu Glu Leu 325 330 335 Thr Glu Ser Cys Glu Thr Lys
Lys Leu Gly Gln Ser Leu Asp Cys Asn 340 345 350 Ala Glu Val Tyr Val
Val Pro Trp Glu Lys Lys Ile Tyr Pro Thr Val 355 360 365 Asn Cys Gln
Pro Leu Gly Met Ile Ser Leu Met Lys Arg Pro Pro Gly 370 375 380 Phe
Ser Pro Phe Arg Ser Ser Arg Ile Gly Glu Ile Lys Glu Glu Thr 385 390
395 400 Thr Ser His Leu Arg Ser Cys Glu Tyr Lys Gly Arg Pro Pro Lys
Ala 405 410 415 Gly Ala Glu Pro Ala Ser Glu Arg Glu Val Ser 420 425
318338PRTHomo sapiens 318Met Ser Leu Ser Ala Phe Thr Leu Phe Leu
Ala Leu Ile Gly Gly Thr 1 5 10 15 Ser Gly Gln Tyr Tyr Asp Tyr Asp
Phe Pro Leu Ser Ile Tyr Gly Gln 20 25 30 Ser Ser Pro Asn Cys Ala
Pro Glu Cys Asn Cys Pro Glu Ser Tyr Pro 35 40 45 Ser Ala Met Tyr
Cys Asp Glu Leu Lys Leu Lys Ser Val Pro Met Val 50 55 60 Pro Pro
Gly Ile Lys Tyr Leu Tyr Leu Arg Asn Asn Gln Ile Asp His 65 70 75 80
Ile Asp Glu Lys Ala Phe Glu Asn Val Thr Asp Leu Gln Trp Leu Ile 85
90 95 Leu Asp His Asn Leu Leu Glu Asn Ser Lys Ile Lys Gly Arg Val
Phe 100 105 110 Ser Lys Leu Lys Gln Leu Lys Lys Leu His Ile Asn His
Asn Asn Leu 115 120 125 Thr Glu Ser Val Gly Pro Leu Pro Lys Ser Leu
Glu Asp Leu Gln Leu 130 135 140 Thr His Asn Lys Ile Thr Lys Leu Gly
Ser Phe Glu Gly Leu Val Asn 145 150 155 160 Leu Thr Phe Ile His Leu
Gln His Asn Arg Leu Lys Glu Asp Ala Val 165 170 175 Ser Ala Ala Phe
Lys Gly Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 180 185 190 Phe Asn
Gln Ile Ala Arg Leu Pro Ser Gly Leu Pro Val Ser Leu Leu 195 200 205
Thr Leu Tyr Leu Asp Asn Asn Lys Ile Ser Asn Ile Pro Asp Glu Tyr 210
215 220 Phe Lys Arg Phe Asn Ala Leu Gln Tyr Leu Arg Leu Ser His Asn
Glu 225 230 235 240 Leu Ala Asp Ser Gly Ile Pro Gly Asn Ser Phe Asn
Val Ser Ser Leu 245 250 255 Val Glu Leu Asp Leu Ser Tyr Asn Lys Leu
Lys Asn Ile Pro Thr Val 260 265 270 Asn Glu Asn Leu Glu Asn Tyr Tyr
Leu Glu Val Asn Gln Leu Glu Lys 275 280 285 Phe Asp Ile Lys Ser Phe
Cys Lys Ile Leu Gly Pro Leu Ser Tyr Ser 290 295 300 Lys Ile Lys His
Leu Arg Leu Asp Gly Asn Arg Ile Ser Glu Thr Ser 305 310 315 320 Leu
Pro Pro Asp Met Tyr Glu Cys Leu Arg Val Ala Asn Glu Val Thr 325 330
335 Leu Asn 3195430PRTHomo sapiens 319Met Ser Ser Ser Asp Glu Glu
Thr Leu Ser Glu Arg Ser Cys Arg Ser 1 5 10 15 Glu Arg Ser Cys Arg
Ser Glu Arg Ser Tyr Arg Ser Glu Arg Ser Gly 20 25 30 Ser Leu Ser
Pro Cys Pro Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro 35 40 45 Leu
His Glu Gln Lys Lys Arg Lys Ser Gln Asp Ser Val Leu Asp Pro 50 55
60 Ala Glu Arg Ala Val Val Arg Val Ala Asp Glu Arg Asp Arg Val Gln
65 70 75 80 Lys Lys Thr Phe Thr Lys Trp Val Asn Lys His Leu Met Lys
Val Arg 85 90 95 Lys His Ile Asn Asp Leu Tyr Glu Asp Leu Arg Asp
Gly His Asn Leu 100 105 110 Ile Ser Leu Leu Glu Val Leu Ser Gly Ile
Lys Leu Pro Arg Glu Lys 115 120 125 Gly Arg Met Arg Phe His Arg Leu
Gln Asn Val Gln Ile Ala Leu Asp 130 135 140 Phe Leu Lys Gln Arg Gln
Val Lys Leu Val Asn Ile Arg Asn Asp Asp 145 150 155 160 Ile Thr Asp
Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile 165 170 175 Ile
Leu His Phe Gln Ile Ser Asp Ile Tyr Ile Ser Gly Glu Ser Gly 180 185
190 Asp Met Ser Ala Lys Glu Lys Leu Leu Leu Trp Thr Gln Lys Val Thr
195 200 205 Ala Gly Tyr Thr Gly Ile Lys Cys Thr Asn Phe Ser Ser Cys
Trp Ser 210 215 220 Asp Gly Lys Met Phe Asn Ala Leu Ile His Arg Tyr
Arg Pro Asp Leu 225 230 235 240 Val Asp Met Glu Arg Val Gln Ile Gln
Ser Asn Arg Glu Asn Leu Glu 245 250 255 Gln Ala Phe Glu Val Ala Glu
Arg Leu Gly Val Thr Arg Leu Leu Asp 260 265 270 Ala Glu Asp Val Asp
Val Pro Ser Pro Asp Glu Lys Ser Val Ile Thr 275 280 285 Tyr Val Ser
Ser Ile Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly 290 295 300 Glu
Gly Ile Ser Ala Thr Glu Val Asp Ser Arg Trp Gln Glu Tyr Gln 305 310
315 320 Ser Arg Val Asp Ser Leu Ile Pro Trp Ile Lys Gln His Thr Ile
Leu 325 330 335 Met Ser Asp Lys Thr Phe Pro Gln Asn Pro Val Glu Leu
Lys Ala Leu 340 345 350 Tyr Asn Gln Tyr Ile His Phe Lys Glu Thr Glu
Ile Leu Ala Lys Glu 355 360 365 Arg Glu Lys Gly Arg Ile Glu Glu Leu
Tyr Lys Leu Leu Glu Val Trp 370 375 380 Ile Glu Phe Gly Arg Ile Lys
Leu Pro Gln Gly Tyr His Pro Asn Asp 385 390 395 400 Val Glu Glu Glu
Trp Gly Lys Leu Ile Ile Glu Met Leu Glu Arg Glu 405 410 415 Lys Ser
Leu Arg Pro Ala Val Glu Arg Leu Glu Leu Leu Leu Gln Ile 420 425 430
Ala Asn Lys Ile Gln Asn Gly Ala Leu Asn Cys Glu Glu Lys Leu Thr 435
440 445 Leu Ala Lys Asn Thr Leu Gln Ala Asp Ala Ala His Leu Glu Ser
Gly 450 455 460 Gln Pro Val Gln Cys Glu Ser Asp Val Ile Met Tyr Ile
Gln Glu Cys 465 470 475 480 Glu Gly Leu Ile Arg Gln Leu Gln Val Asp
Leu Gln Ile Leu Arg Asp 485 490 495 Glu Asn Tyr Tyr Gln Leu Glu Glu
Leu Ala Phe Arg Val Met Arg Leu 500 505 510 Gln Asp Glu Leu Val Thr
Leu Arg Leu Glu Cys Thr Asn Leu Tyr Arg 515 520 525 Lys Gly His Phe
Thr Ser Leu Glu Leu Val Pro Pro Ser Thr Leu Thr 530 535 540 Thr Thr
His Leu Lys Ala Glu Pro Leu Thr Lys Ala Thr His Ser Ser 545 550 555
560 Ser Thr Ser Trp Phe Arg Lys Pro Met Thr Arg Ala Glu Leu Val Ala
565 570 575 Ile Ser Ser Ser Glu Asp Glu Gly Asn Leu Arg Phe Val Tyr
Glu Leu 580 585 590 Leu Ser Trp Val Glu Glu Met Gln Met Lys Leu Glu
Arg Ala Glu Trp 595 600 605 Gly Asn Asp Leu Pro Ser Val Glu Leu Gln
Leu Glu Thr Gln Gln His 610 615 620 Ile His Thr Ser Val Glu Glu Leu
Gly Ser Ser Val Lys Glu Ala Arg 625 630 635 640 Leu Tyr Glu Gly Lys
Met Ser Gln Asn Phe His Thr Ser Tyr Ala Glu 645 650 655 Thr Leu Gly
Lys Leu Glu Thr Gln Tyr Cys Lys Leu Lys Glu Thr Ser 660 665 670 Ser
Phe Arg Met Arg His Leu Gln Ser Leu His Lys Phe Val Ser Arg 675 680
685 Ala Thr Ala Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Leu
690 695 700 Ala Tyr Asp Trp Ser Asp Asn Asn Ser Asn Ile Ser Ala Lys
Arg Asn 705 710 715 720 Tyr Phe Ser Glu Leu Thr Met Glu Leu Glu Glu
Lys Gln Asp Val Phe 725 730 735 Arg Ser Leu Gln Asp Thr Ala Glu Leu
Leu Ser Leu Glu Asn His Pro 740 745 750 Ala Lys Gln Thr Val Glu Ala
Tyr Ser Ala Ala Val Gln Ser Gln Leu 755 760 765 Gln Trp Met Lys Gln
Leu Cys Leu Cys Val Glu Gln His Val Lys Glu 770 775 780 Asn Thr Ala
Tyr Phe Gln Phe Phe Ser Asp Ala Arg Glu Leu Glu Ser 785 790 795 800
Phe Leu Arg Asn Leu Gln Asp Ser Ile Lys Arg Lys Tyr Ser Cys Asp 805
810 815 His Asn Thr Ser Leu Ser Arg Leu Glu Asp Leu Leu Gln Asp Ser
Met 820 825 830 Asp Glu Lys Glu Gln Leu Ile Gln Ser Lys Ser Ser Val
Ala Ser Leu 835 840 845 Val Gly Arg Ser Lys Thr Ile Val Gln Leu Lys
Pro Arg Ser Pro Asp 850 855 860 His Val Leu Lys Asn Thr Ile Ser Val
Lys Ala Val Cys Asp Tyr Arg 865 870 875 880 Gln Ile Glu Ile Thr Ile
Cys Lys Asn Asp Glu Cys Val Leu Glu Asp 885 890 895 Asn Ser Gln Arg
Thr Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu 900 905 910 Ala Met
Val Pro Ser Val Cys Phe Leu Ile Pro Pro Pro Asn Lys Asp 915 920 925
Ala Ile Glu Met Ala Ser Arg Val Glu Gln Ser Tyr Gln Lys Val Met 930
935 940 Ala Leu Trp His Gln Leu His Val Asn Thr Lys Ser Leu Ile Ser
Trp 945 950 955 960 Asn Tyr Leu Arg Lys Asp Leu Asp Leu Val Gln Thr
Trp Asn Leu Glu 965 970 975 Lys Leu Arg Ser Ser Ala Pro Gly Glu Cys
His Gln Ile Met Lys Asn 980 985 990 Leu Gln Ala His Tyr Glu Asp Phe
Leu Gln Asp Ser Arg Asp Ser Val 995 1000 1005 Leu Phe Ser Val Ala
Asp Arg Leu Arg Leu Glu Glu Glu Val Glu 1010 1015 1020 Ala Cys Lys
Ala Arg Phe Gln His Leu Met Lys Ser Met Glu Asn 1025 1030 1035 Glu
Asp Lys Glu Glu Thr Val Ala Lys Met Tyr Ile Ser Glu Leu 1040 1045
1050 Lys Asn Ile Arg Leu Arg Leu Glu Glu Tyr Glu Gln Arg Val Val
1055 1060 1065 Lys Arg Ile Gln Ser Leu Ala Ser Ser Arg Thr Asp Arg
Asp Ala 1070 1075 1080 Trp Gln Asp Asn Ala Leu Arg Ile Ala Glu Gln
Glu His Thr Gln 1085 1090 1095 Glu Asp Leu Gln Gln Leu Arg Ser Asp
Leu Asp Ala Val Ser Met 1100 1105 1110 Lys Cys Asp Ser Phe Leu His
Gln Ser Pro Ser Ser Ser Ser Val 1115 1120 1125 Pro Thr Leu Arg Ser
Glu Leu Asn Leu Leu Val Glu Lys Met Asp 1130 1135 1140 His Val Tyr
Gly Leu Ser Thr Val Tyr Leu Asn Lys Leu Lys Thr 1145 1150 1155 Val
Asp Val Ile Val Arg Ser Ile Gln Asp Ala Glu Leu Leu Val 1160 1165
1170 Lys Gly
Tyr Glu Ile Lys Leu Ser Gln Glu Glu Val Val Leu Ala 1175 1180 1185
Asp Leu Ser Ala Leu Glu Ala His Trp Ser Thr Leu Arg His Trp 1190
1195 1200 Leu Ser Asp Val Lys Asp Lys Asn Ser Val Phe Ser Val Leu
Asp 1205 1210 1215 Glu Glu Ile Ala Lys Ala Lys Val Val Ala Glu Gln
Met Ser Arg 1220 1225 1230 Leu Thr Pro Glu Arg Asn Leu Asp Leu Glu
Arg Tyr Gln Glu Lys 1235 1240 1245 Gly Ser Gln Leu Gln Glu Arg Trp
His Arg Val Ile Ala Gln Leu 1250 1255 1260 Glu Ile Arg Gln Ser Glu
Leu Glu Ser Ile Gln Glu Val Leu Gly 1265 1270 1275 Asp Tyr Arg Ala
Cys His Gly Thr Leu Ile Lys Trp Ile Glu Glu 1280 1285 1290 Thr Thr
Ala Gln Gln Glu Met Met Lys Pro Gly Gln Ala Glu Asp 1295 1300 1305
Ser Arg Val Leu Ser Glu Gln Leu Ser Gln Gln Thr Ala Leu Phe 1310
1315 1320 Ala Glu Ile Glu Arg Asn Gln Thr Lys Leu Asp Gln Cys Gln
Lys 1325 1330 1335 Phe Ser Gln Gln Tyr Ser Thr Ile Val Lys Asp Tyr
Glu Leu Gln 1340 1345 1350 Leu Met Thr Tyr Lys Ala Phe Val Glu Ser
Gln Gln Lys Ser Pro 1355 1360 1365 Gly Lys Arg Arg Arg Met Leu Ser
Ser Ser Asp Ala Ile Thr Gln 1370 1375 1380 Glu Phe Met Asp Leu Arg
Thr Arg Tyr Thr Ala Leu Val Thr Leu 1385 1390 1395 Thr Thr Gln His
Val Lys Tyr Ile Ser Asp Ala Leu Arg Arg Leu 1400 1405 1410 Glu Glu
Glu Glu Lys Val Val Glu Glu Glu Lys Gln Glu His Val 1415 1420 1425
Glu Lys Val Lys Glu Leu Leu Gly Trp Val Ser Thr Leu Ala Arg 1430
1435 1440 Asn Thr Gln Gly Lys Ala Thr Ser Ser Glu Thr Lys Glu Ser
Thr 1445 1450 1455 Asp Ile Glu Lys Ala Ile Leu Glu Gln Gln Val Leu
Ser Glu Glu 1460 1465 1470 Leu Thr Thr Lys Lys Glu Gln Val Ser Glu
Ala Ile Lys Thr Ser 1475 1480 1485 Gln Ile Phe Leu Ala Lys His Gly
His Lys Leu Ser Glu Lys Glu 1490 1495 1500 Lys Lys Gln Ile Ser Glu
Gln Leu Asn Ala Leu Asn Lys Ala Tyr 1505 1510 1515 His Asp Leu Cys
Asp Gly Ser Ala Asn Gln Leu Gln Gln Leu Gln 1520 1525 1530 Ser Gln
Leu Ala His Gln Thr Glu Gln Lys Thr Leu Gln Lys Gln 1535 1540 1545
Gln Asn Thr Cys His Gln Gln Leu Glu Asp Leu Cys Ser Trp Val 1550
1555 1560 Gly Gln Ala Glu Arg Ala Leu Ala Gly His Gln Gly Arg Thr
Thr 1565 1570 1575 Gln Gln Asp Leu Ser Ala Leu Gln Lys Asn Gln Ser
Asp Leu Lys 1580 1585 1590 Asp Leu Gln Asp Asp Ile Gln Asn Arg Ala
Thr Ser Phe Ala Thr 1595 1600 1605 Val Val Lys Asp Ile Glu Gly Phe
Met Glu Glu Asn Gln Thr Lys 1610 1615 1620 Leu Ser Pro Arg Glu Leu
Thr Ala Leu Arg Glu Lys Leu His Gln 1625 1630 1635 Ala Lys Glu Gln
Tyr Glu Ala Leu Gln Glu Glu Thr Arg Val Ala 1640 1645 1650 Gln Lys
Glu Leu Glu Glu Ala Val Thr Ser Ala Leu Gln Gln Glu 1655 1660 1665
Thr Glu Lys Ser Lys Ala Ala Lys Glu Leu Ala Glu Asn Lys Lys 1670
1675 1680 Lys Ile Asp Ala Leu Leu Asp Trp Val Thr Ser Val Gly Ser
Ser 1685 1690 1695 Gly Gly Gln Leu Leu Thr Asn Leu Pro Gly Met Glu
Gln Leu Ser 1700 1705 1710 Gly Ala Ser Leu Glu Lys Gly Ala Leu Asp
Thr Thr Asp Gly Tyr 1715 1720 1725 Met Gly Val Asn Gln Ala Pro Glu
Lys Leu Asp Lys Gln Cys Glu 1730 1735 1740 Met Met Lys Ala Arg His
Gln Glu Leu Leu Ser Gln Gln Gln Asn 1745 1750 1755 Phe Ile Leu Ala
Thr Gln Ser Ala Gln Ala Phe Leu Asp Gln His 1760 1765 1770 Gly His
Asn Leu Thr Pro Glu Glu Gln Gln Met Leu Gln Gln Lys 1775 1780 1785
Leu Gly Glu Leu Lys Glu Gln Tyr Ser Thr Ser Leu Ala Gln Ser 1790
1795 1800 Glu Ala Glu Leu Lys Gln Val Gln Thr Leu Gln Asp Glu Leu
Gln 1805 1810 1815 Lys Phe Leu Gln Asp His Lys Glu Phe Glu Ser Trp
Leu Glu Arg 1820 1825 1830 Ser Glu Lys Glu Leu Glu Asn Met His Lys
Gly Gly Ser Ser Pro 1835 1840 1845 Glu Thr Leu Pro Ser Leu Leu Lys
Arg Gln Gly Ser Phe Ser Glu 1850 1855 1860 Asp Val Ile Ser His Lys
Gly Asp Leu Arg Phe Val Thr Ile Ser 1865 1870 1875 Gly Gln Lys Val
Leu Asp Met Glu Asn Ser Phe Lys Glu Gly Lys 1880 1885 1890 Glu Pro
Ser Glu Ile Gly Asn Leu Val Lys Asp Lys Leu Lys Asp 1895 1900 1905
Ala Thr Glu Arg Tyr Thr Ala Leu His Ser Lys Cys Thr Arg Leu 1910
1915 1920 Gly Ser His Leu Asn Met Leu Leu Gly Gln Tyr His Gln Phe
Gln 1925 1930 1935 Asn Ser Ala Asp Ser Leu Gln Ala Trp Met Gln Ala
Cys Glu Ala 1940 1945 1950 Asn Val Glu Lys Leu Leu Ser Asp Thr Val
Ala Ser Asp Pro Gly 1955 1960 1965 Val Leu Gln Glu Gln Leu Ala Thr
Thr Lys Gln Leu Gln Glu Glu 1970 1975 1980 Leu Ala Glu His Gln Val
Pro Val Glu Lys Leu Gln Lys Val Ala 1985 1990 1995 Arg Asp Ile Met
Glu Ile Glu Gly Glu Pro Ala Pro Asp His Arg 2000 2005 2010 His Val
Gln Glu Thr Thr Asp Ser Ile Leu Ser His Phe Gln Ser 2015 2020 2025
Leu Ser Tyr Ser Leu Ala Glu Arg Ser Ser Leu Leu Gln Lys Ala 2030
2035 2040 Ile Ala Gln Ser Gln Ser Val Gln Glu Ser Leu Glu Ser Leu
Leu 2045 2050 2055 Gln Ser Ile Gly Glu Val Glu Gln Asn Leu Glu Gly
Lys Gln Val 2060 2065 2070 Ser Ser Leu Ser Ser Gly Val Ile Gln Glu
Ala Leu Ala Thr Asn 2075 2080 2085 Met Lys Leu Lys Gln Asp Ile Ala
Arg Gln Lys Ser Ser Leu Glu 2090 2095 2100 Ala Thr Arg Glu Met Val
Thr Arg Phe Met Glu Thr Ala Asp Ser 2105 2110 2115 Thr Thr Ala Ala
Val Leu Gln Gly Lys Leu Ala Glu Val Ser Gln 2120 2125 2130 Arg Phe
Glu Gln Leu Cys Leu Gln Gln Gln Glu Lys Glu Ser Ser 2135 2140 2145
Leu Lys Lys Leu Leu Pro Gln Ala Glu Met Phe Glu His Leu Ser 2150
2155 2160 Gly Lys Leu Gln Gln Phe Met Glu Asn Lys Ser Arg Met Leu
Ala 2165 2170 2175 Ser Gly Asn Gln Pro Asp Gln Asp Ile Thr His Phe
Phe Gln Gln 2180 2185 2190 Ile Gln Glu Leu Asn Leu Glu Met Glu Asp
Gln Gln Glu Asn Leu 2195 2200 2205 Asp Thr Leu Glu His Leu Val Thr
Glu Leu Ser Ser Cys Gly Phe 2210 2215 2220 Ala Leu Asp Leu Cys Gln
His Gln Asp Arg Val Gln Asn Leu Arg 2225 2230 2235 Lys Asp Phe Thr
Glu Leu Gln Lys Thr Val Lys Glu Arg Glu Lys 2240 2245 2250 Asp Ala
Ser Ser Cys Gln Glu Gln Leu Asp Glu Phe Arg Lys Leu 2255 2260 2265
Val Arg Thr Phe Gln Lys Trp Leu Lys Glu Thr Glu Gly Ser Ile 2270
2275 2280 Pro Pro Thr Glu Thr Ser Met Ser Ala Lys Glu Leu Glu Lys
Gln 2285 2290 2295 Ile Glu His Leu Lys Ser Leu Leu Asp Asp Trp Ala
Ser Lys Gly 2300 2305 2310 Thr Leu Val Glu Glu Ile Asn Cys Lys Gly
Thr Ser Leu Glu Asn 2315 2320 2325 Leu Ile Met Glu Ile Thr Ala Pro
Asp Ser Gln Gly Lys Thr Gly 2330 2335 2340 Ser Ile Leu Pro Ser Val
Gly Ser Ser Val Gly Ser Val Asn Gly 2345 2350 2355 Tyr His Thr Cys
Lys Asp Leu Thr Glu Ile Gln Cys Asp Met Ser 2360 2365 2370 Asp Val
Asn Leu Lys Tyr Glu Lys Leu Gly Gly Val Leu His Glu 2375 2380 2385
Arg Gln Glu Ser Leu Gln Ala Ile Leu Asn Arg Met Glu Glu Val 2390
2395 2400 His Lys Glu Ala Asn Ser Val Leu Gln Trp Leu Glu Ser Lys
Glu 2405 2410 2415 Glu Val Leu Lys Ser Met Asp Ala Met Ser Ser Pro
Thr Lys Thr 2420 2425 2430 Glu Thr Val Lys Ala Gln Ala Glu Ser Asn
Lys Ala Phe Leu Ala 2435 2440 2445 Glu Leu Glu Gln Asn Ser Pro Lys
Ile Gln Lys Val Lys Glu Ala 2450 2455 2460 Leu Ala Gly Leu Leu Val
Thr Tyr Pro Asn Ser Gln Glu Ala Glu 2465 2470 2475 Asn Trp Lys Lys
Ile Gln Glu Glu Leu Asn Ser Arg Trp Glu Arg 2480 2485 2490 Ala Thr
Glu Val Thr Val Ala Arg Gln Arg Gln Leu Glu Glu Ser 2495 2500 2505
Ala Ser His Leu Ala Cys Phe Gln Ala Ala Glu Ser Gln Leu Arg 2510
2515 2520 Pro Trp Leu Met Glu Lys Glu Leu Met Met Gly Val Leu Gly
Pro 2525 2530 2535 Leu Ser Ile Asp Pro Asn Met Leu Asn Ala Gln Lys
Gln Gln Val 2540 2545 2550 Gln Phe Met Leu Lys Glu Phe Glu Ala Arg
Arg Gln Gln His Glu 2555 2560 2565 Gln Leu Asn Glu Ala Ala Gln Gly
Ile Leu Thr Gly Pro Gly Asp 2570 2575 2580 Val Ser Leu Ser Thr Ser
Gln Val Gln Lys Glu Leu Gln Ser Ile 2585 2590 2595 Asn Gln Lys Trp
Val Glu Leu Thr Asp Lys Leu Asn Ser Arg Ser 2600 2605 2610 Ser Gln
Ile Asp Gln Ala Ile Val Lys Ser Thr Gln Tyr Gln Glu 2615 2620 2625
Leu Leu Gln Asp Leu Ser Glu Lys Val Arg Ala Val Gly Gln Arg 2630
2635 2640 Leu Ser Val Gln Ser Ala Ile Ser Thr Gln Pro Glu Ala Val
Lys 2645 2650 2655 Gln Gln Leu Glu Glu Thr Ser Glu Ile Arg Ser Asp
Leu Glu Gln 2660 2665 2670 Leu Asp His Glu Val Lys Glu Ala Gln Thr
Leu Cys Asp Glu Leu 2675 2680 2685 Ser Val Leu Ile Gly Glu Gln Tyr
Leu Lys Asp Glu Leu Lys Lys 2690 2695 2700 Arg Leu Glu Thr Val Ala
Leu Pro Leu Gln Gly Leu Glu Asp Leu 2705 2710 2715 Ala Ala Asp Arg
Ile Asn Arg Leu Gln Ala Ala Leu Ala Ser Thr 2720 2725 2730 Gln Gln
Phe Gln Gln Met Phe Asp Glu Leu Arg Thr Trp Leu Asp 2735 2740 2745
Asp Lys Gln Ser Gln Gln Ala Lys Asn Cys Pro Ile Ser Ala Lys 2750
2755 2760 Leu Glu Arg Leu Gln Ser Gln Leu Gln Glu Asn Glu Glu Phe
Gln 2765 2770 2775 Lys Ser Leu Asn Gln His Ser Gly Ser Tyr Glu Val
Ile Val Ala 2780 2785 2790 Glu Gly Glu Ser Leu Leu Leu Ser Val Pro
Pro Gly Glu Glu Lys 2795 2800 2805 Arg Thr Leu Gln Asn Gln Leu Val
Glu Leu Lys Asn His Trp Glu 2810 2815 2820 Glu Leu Ser Lys Lys Thr
Ala Asp Arg Gln Ser Arg Leu Lys Asp 2825 2830 2835 Cys Met Gln Lys
Ala Gln Lys Tyr Gln Trp His Val Glu Asp Leu 2840 2845 2850 Val Pro
Trp Ile Glu Asp Cys Lys Ala Lys Met Ser Glu Leu Arg 2855 2860 2865
Val Thr Leu Asp Pro Val Gln Leu Glu Ser Ser Leu Leu Arg Ser 2870
2875 2880 Lys Ala Met Leu Asn Glu Val Glu Lys Arg Arg Ser Leu Leu
Glu 2885 2890 2895 Ile Leu Asn Ser Ala Ala Asp Ile Leu Ile Asn Ser
Ser Glu Ala 2900 2905 2910 Asp Glu Asp Gly Ile Arg Asp Glu Lys Ala
Gly Ile Asn Gln Asn 2915 2920 2925 Met Asp Ala Val Thr Glu Glu Leu
Gln Ala Lys Thr Gly Ser Leu 2930 2935 2940 Glu Glu Met Thr Gln Arg
Leu Arg Glu Phe Gln Glu Ser Phe Lys 2945 2950 2955 Asn Ile Glu Lys
Lys Val Glu Gly Ala Lys His Gln Leu Glu Ile 2960 2965 2970 Phe Asp
Ala Leu Gly Ser Gln Ala Cys Ser Asn Lys Asn Leu Glu 2975 2980 2985
Lys Leu Arg Ala Gln Gln Glu Val Leu Gln Ala Leu Glu Pro Gln 2990
2995 3000 Val Asp Tyr Leu Arg Asn Phe Thr Gln Gly Leu Val Glu Asp
Ala 3005 3010 3015 Pro Asp Gly Ser Asp Ala Ser Gln Leu Leu His Gln
Ala Glu Val 3020 3025 3030 Ala Gln Gln Glu Phe Leu Glu Val Lys Gln
Arg Val Asn Ser Gly 3035 3040 3045 Cys Val Met Met Glu Asn Lys Leu
Glu Gly Ile Gly Gln Phe His 3050 3055 3060 Cys Arg Val Arg Glu Met
Phe Ser Gln Leu Ala Asp Leu Asp Asp 3065 3070 3075 Glu Leu Asp Gly
Met Gly Ala Ile Gly Arg Asp Thr Asp Ser Leu 3080 3085 3090 Gln Ser
Gln Ile Glu Asp Val Arg Leu Phe Leu Asn Lys Ile His 3095 3100 3105
Val Leu Lys Leu Asp Ile Glu Ala Ser Glu Ala Glu Cys Arg His 3110
3115 3120 Met Leu Glu Glu Glu Gly Thr Leu Asp Leu Leu Gly Leu Lys
Arg 3125 3130 3135 Glu Leu Glu Ala Leu Asn Lys Gln Cys Gly Lys Leu
Thr Glu Arg 3140 3145 3150 Gly Lys Ala Arg Gln Glu Gln Leu Glu Leu
Thr Leu Gly Arg Val 3155 3160 3165 Glu Asp Phe Tyr Arg Lys Leu Lys
Gly Leu Asn Asp Ala Thr Thr 3170 3175 3180 Ala Ala Glu Glu Ala Glu
Ala Leu Gln Trp Val Val Gly Thr Glu 3185 3190 3195 Val Glu Ile Ile
Asn Gln Gln Leu Ala Asp Phe Lys Met Phe Gln 3200 3205 3210 Lys Glu
Gln Val Asp Pro Leu Gln Met Lys Leu Gln Gln Val Asn 3215 3220 3225
Gly Leu Gly Gln Gly Leu Ile Gln Ser Ala Gly Lys Asp Cys Asp 3230
3235 3240 Val Gln Gly Leu Glu His Asp Met Glu Glu Ile Asn Ala Arg
Trp 3245 3250 3255 Asn Thr Leu Asn Lys Lys Val Ala Gln Arg Ile Ala
Gln Leu Gln 3260 3265 3270 Glu Ala Leu Leu His Cys Gly Lys Phe Gln
Asp Ala Leu Glu Pro 3275 3280 3285 Leu Leu Ser Trp Leu Ala Asp Thr
Glu Glu Leu Ile Ala Asn Gln 3290 3295 3300 Lys Pro Pro Ser Ala Glu
Tyr Lys Val Val Lys Ala Gln Ile Gln 3305 3310 3315 Glu Gln Lys Leu
Leu Gln Arg Leu Leu Asp Asp Arg Lys Ala Thr 3320 3325 3330 Val Asp
Met Leu Gln Ala Glu Gly Gly Arg Ile Ala Gln Ser Ala 3335 3340 3345
Glu Leu Ala Asp Arg Glu Lys Ile Thr Gly Gln Leu Glu Ser Leu 3350
3355 3360 Glu Ser Arg Trp Thr Glu Leu Leu Ser Lys Ala Ala Ala Arg
Gln
3365 3370 3375 Lys Gln Leu Glu Asp Ile Leu Val Leu Ala Lys Gln Phe
His Glu 3380 3385 3390 Thr Ala Glu Pro Ile Ser Asp Phe Leu Ser Val
Thr Glu Lys Lys 3395 3400 3405 Leu Ala Asn Ser Glu Pro Val Gly Thr
Gln Thr Ala Lys Ile Gln 3410 3415 3420 Gln Gln Ile Ile Arg His Lys
Ala Leu Glu Glu Asp Ile Glu Asn 3425 3430 3435 His Ala Thr Asp Val
His Gln Ala Val Lys Ile Gly Gln Ser Leu 3440 3445 3450 Ser Ser Leu
Thr Ser Pro Ala Glu Gln Gly Val Leu Ser Glu Lys 3455 3460 3465 Ile
Asp Ser Leu Gln Ala Arg Tyr Ser Glu Ile Gln Asp Arg Cys 3470 3475
3480 Cys Arg Lys Ala Ala Leu Leu Asp Gln Ala Leu Ser Asn Ala Arg
3485 3490 3495 Leu Phe Gly Glu Asp Glu Val Glu Val Leu Asn Trp Leu
Ala Glu 3500 3505 3510 Val Glu Asp Lys Leu Ser Ser Val Phe Val Lys
Asp Phe Lys Gln 3515 3520 3525 Asp Val Leu His Arg Gln His Ala Asp
His Leu Ala Leu Asn Glu 3530 3535 3540 Glu Ile Val Asn Arg Lys Lys
Asn Val Asp Gln Ala Ile Lys Asn 3545 3550 3555 Gly Gln Ala Leu Leu
Lys Gln Thr Thr Gly Glu Glu Val Leu Leu 3560 3565 3570 Ile Gln Glu
Lys Leu Asp Gly Ile Lys Thr Arg Tyr Ala Asp Ile 3575 3580 3585 Thr
Val Thr Ser Ser Lys Ala Leu Arg Thr Leu Glu Gln Ala Arg 3590 3595
3600 Gln Leu Ala Thr Lys Phe Gln Ser Thr Tyr Glu Glu Leu Thr Gly
3605 3610 3615 Trp Leu Arg Glu Val Glu Glu Glu Leu Ala Thr Ser Gly
Gly Gln 3620 3625 3630 Ser Pro Thr Gly Glu Gln Ile Pro Gln Phe Gln
Gln Arg Gln Lys 3635 3640 3645 Glu Leu Lys Lys Glu Val Met Glu His
Arg Leu Val Leu Asp Thr 3650 3655 3660 Val Asn Glu Val Ser Arg Ala
Leu Leu Glu Leu Val Pro Trp Arg 3665 3670 3675 Ala Arg Glu Gly Leu
Asp Lys Leu Val Ser Asp Ala Asn Glu Gln 3680 3685 3690 Tyr Lys Leu
Val Ser Asp Thr Ile Gly Gln Arg Val Asp Glu Ile 3695 3700 3705 Asp
Ala Ala Ile Gln Arg Ser Gln Gln Tyr Glu Gln Ala Ala Asp 3710 3715
3720 Ala Glu Leu Ala Trp Val Ala Glu Thr Lys Arg Lys Leu Met Ala
3725 3730 3735 Leu Gly Pro Ile Arg Leu Glu Gln Asp Gln Thr Thr Ala
Gln Leu 3740 3745 3750 Gln Val Gln Lys Ala Phe Ser Ile Asp Ile Ile
Arg His Lys Asp 3755 3760 3765 Ser Met Asp Glu Leu Phe Ser His Arg
Ser Glu Ile Phe Gly Thr 3770 3775 3780 Cys Gly Glu Glu Gln Lys Thr
Val Leu Gln Glu Lys Thr Glu Ser 3785 3790 3795 Leu Ile Gln Gln Tyr
Glu Ala Ile Ser Leu Leu Asn Ser Glu Arg 3800 3805 3810 Tyr Ala Arg
Leu Glu Arg Ala Gln Val Leu Val Asn Gln Phe Trp 3815 3820 3825 Glu
Thr Tyr Glu Glu Leu Ser Pro Trp Ile Glu Glu Thr Arg Ala 3830 3835
3840 Leu Ile Ala Gln Leu Pro Ser Pro Ala Ile Asp His Glu Gln Leu
3845 3850 3855 Arg Gln Gln Gln Glu Glu Met Arg Gln Leu Arg Glu Ser
Ile Ala 3860 3865 3870 Glu His Lys Pro His Ile Asp Lys Leu Leu Lys
Ile Gly Pro Gln 3875 3880 3885 Leu Lys Glu Leu Asn Pro Glu Glu Gly
Glu Met Val Glu Glu Lys 3890 3895 3900 Tyr Gln Lys Ala Glu Asn Met
Tyr Ala Gln Ile Lys Glu Glu Val 3905 3910 3915 Arg Gln Arg Ala Leu
Ala Leu Asp Glu Ala Val Ser Gln Ser Thr 3920 3925 3930 Gln Ile Thr
Glu Phe His Asp Lys Ile Glu Pro Met Leu Glu Thr 3935 3940 3945 Leu
Glu Asn Leu Ser Ser Arg Leu Arg Met Pro Pro Leu Ile Pro 3950 3955
3960 Ala Glu Val Asp Lys Ile Arg Glu Cys Ile Ser Asp Asn Lys Ser
3965 3970 3975 Ala Thr Val Glu Leu Glu Lys Leu Gln Pro Ser Phe Glu
Ala Leu 3980 3985 3990 Lys Arg Arg Gly Glu Glu Leu Ile Gly Arg Ser
Gln Gly Ala Asp 3995 4000 4005 Lys Asp Leu Ala Ala Lys Glu Ile Gln
Asp Lys Leu Asp Gln Met 4010 4015 4020 Val Phe Phe Trp Glu Asp Ile
Lys Ala Arg Ala Glu Glu Arg Glu 4025 4030 4035 Ile Lys Phe Leu Asp
Val Leu Glu Leu Ala Glu Lys Phe Trp Tyr 4040 4045 4050 Asp Met Ala
Ala Leu Leu Thr Thr Ile Lys Asp Thr Gln Asp Ile 4055 4060 4065 Val
His Asp Leu Glu Ser Pro Gly Ile Asp Pro Ser Ile Ile Lys 4070 4075
4080 Gln Gln Val Glu Ala Ala Glu Thr Ile Lys Glu Glu Thr Asp Gly
4085 4090 4095 Leu His Glu Glu Leu Glu Phe Ile Arg Ile Leu Gly Ala
Asp Leu 4100 4105 4110 Ile Phe Ala Cys Gly Glu Thr Glu Lys Pro Glu
Val Arg Lys Ser 4115 4120 4125 Ile Asp Glu Met Asn Asn Ala Trp Glu
Asn Leu Asn Lys Thr Trp 4130 4135 4140 Lys Glu Arg Leu Glu Lys Leu
Glu Asp Ala Met Gln Ala Ala Val 4145 4150 4155 Gln Tyr Gln Asp Thr
Leu Gln Ala Met Phe Asp Trp Leu Asp Asn 4160 4165 4170 Thr Val Ile
Lys Leu Cys Thr Met Pro Pro Val Gly Thr Asp Leu 4175 4180 4185 Asn
Thr Val Lys Asp Gln Leu Asn Glu Met Lys Glu Phe Lys Val 4190 4195
4200 Glu Val Tyr Gln Gln Gln Ile Glu Met Glu Lys Leu Asn His Gln
4205 4210 4215 Gly Glu Leu Met Leu Lys Lys Ala Thr Asp Glu Thr Asp
Arg Asp 4220 4225 4230 Ile Ile Arg Glu Pro Leu Thr Glu Leu Lys His
Leu Trp Glu Asn 4235 4240 4245 Leu Gly Glu Lys Ile Ala His Arg Gln
His Lys Leu Glu Gly Ala 4250 4255 4260 Leu Leu Ala Leu Gly Gln Phe
Gln His Ala Leu Glu Glu Leu Met 4265 4270 4275 Ser Trp Leu Thr His
Thr Glu Glu Leu Leu Asp Ala Gln Arg Pro 4280 4285 4290 Ile Ser Gly
Asp Pro Lys Val Ile Glu Val Glu Leu Ala Lys His 4295 4300 4305 His
Val Leu Lys Asn Asp Val Leu Ala His Gln Ala Thr Val Glu 4310 4315
4320 Thr Val Asn Lys Ala Gly Asn Glu Leu Leu Glu Ser Ser Ala Gly
4325 4330 4335 Asp Asp Ala Ser Ser Leu Arg Ser Arg Leu Glu Ala Met
Asn Gln 4340 4345 4350 Cys Trp Glu Ser Val Leu Gln Lys Thr Glu Glu
Arg Glu Gln Gln 4355 4360 4365 Leu Gln Ser Thr Leu Gln Gln Ala Gln
Gly Phe His Ser Glu Ile 4370 4375 4380 Glu Asp Phe Leu Leu Glu Leu
Thr Arg Met Glu Ser Gln Leu Ser 4385 4390 4395 Ala Ser Lys Pro Thr
Gly Gly Leu Pro Glu Thr Ala Arg Glu Gln 4400 4405 4410 Leu Asp Thr
His Met Glu Leu Tyr Ser Gln Leu Lys Ala Lys Glu 4415 4420 4425 Glu
Thr Tyr Asn Gln Leu Leu Asp Lys Gly Arg Leu Met Leu Leu 4430 4435
4440 Ser Arg Asp Asp Ser Gly Ser Gly Ser Lys Thr Glu Gln Ser Val
4445 4450 4455 Ala Leu Leu Glu Gln Lys Trp His Val Val Ser Ser Lys
Met Glu 4460 4465 4470 Glu Arg Lys Ser Lys Leu Glu Glu Ala Leu Asn
Leu Ala Thr Glu 4475 4480 4485 Phe Gln Asn Ser Leu Gln Glu Phe Ile
Asn Trp Leu Thr Leu Ala 4490 4495 4500 Glu Gln Ser Leu Asn Ile Ala
Ser Pro Pro Ser Leu Ile Leu Asn 4505 4510 4515 Thr Val Leu Ser Gln
Ile Glu Glu His Lys Val Phe Ala Asn Glu 4520 4525 4530 Val Asn Ala
His Arg Asp Gln Ile Ile Glu Leu Asp Gln Thr Gly 4535 4540 4545 Asn
Gln Leu Lys Phe Leu Ser Gln Lys Gln Asp Val Val Leu Ile 4550 4555
4560 Lys Asn Leu Leu Val Ser Val Gln Ser Arg Trp Glu Lys Val Val
4565 4570 4575 Gln Arg Ser Ile Glu Arg Gly Arg Ser Leu Asp Asp Ala
Arg Lys 4580 4585 4590 Arg Ala Lys Gln Phe His Glu Ala Trp Lys Lys
Leu Ile Asp Trp 4595 4600 4605 Leu Glu Asp Ala Glu Ser His Leu Asp
Ser Glu Leu Glu Ile Ser 4610 4615 4620 Asn Asp Pro Asp Lys Ile Lys
Leu Gln Leu Ser Lys His Lys Glu 4625 4630 4635 Phe Gln Lys Thr Leu
Gly Gly Lys Gln Pro Val Tyr Asp Thr Thr 4640 4645 4650 Ile Arg Thr
Gly Arg Ala Leu Lys Glu Lys Thr Leu Leu Pro Glu 4655 4660 4665 Asp
Ser Gln Lys Leu Asp Asn Phe Leu Gly Glu Val Arg Asp Lys 4670 4675
4680 Trp Asp Thr Val Cys Gly Lys Ser Val Glu Arg Gln His Lys Leu
4685 4690 4695 Glu Glu Ala Leu Leu Phe Ser Gly Gln Phe Met Asp Ala
Leu Gln 4700 4705 4710 Ala Leu Val Asp Trp Leu Tyr Lys Val Glu Pro
Gln Leu Ala Glu 4715 4720 4725 Asp Gln Pro Val His Gly Asp Leu Asp
Leu Val Met Asn Leu Met 4730 4735 4740 Asp Ala His Lys Val Phe Gln
Lys Glu Leu Gly Lys Arg Thr Gly 4745 4750 4755 Thr Val Gln Val Leu
Lys Arg Ser Gly Arg Glu Leu Ile Glu Asn 4760 4765 4770 Ser Arg Asp
Asp Thr Thr Trp Val Lys Gly Gln Leu Gln Glu Leu 4775 4780 4785 Ser
Thr Arg Trp Asp Thr Val Cys Lys Leu Ser Val Ser Lys Gln 4790 4795
4800 Ser Arg Leu Glu Gln Ala Leu Lys Gln Ala Glu Val Phe Arg Asp
4805 4810 4815 Thr Val His Met Leu Leu Glu Trp Leu Ser Glu Ala Glu
Gln Thr 4820 4825 4830 Leu Arg Phe Arg Gly Ala Leu Pro Asp Asp Thr
Glu Ala Leu Gln 4835 4840 4845 Ser Leu Ile Asp Thr His Lys Glu Phe
Met Lys Lys Val Glu Glu 4850 4855 4860 Lys Arg Val Asp Val Asn Ser
Ala Val Ala Met Gly Glu Val Ile 4865 4870 4875 Leu Ala Val Cys His
Pro Asp Cys Ile Thr Thr Ile Lys His Trp 4880 4885 4890 Ile Thr Ile
Ile Arg Ala Arg Phe Glu Glu Val Leu Thr Trp Ala 4895 4900 4905 Lys
Gln His Gln Gln Arg Leu Glu Thr Ala Leu Ser Glu Leu Val 4910 4915
4920 Ala Asn Ala Glu Leu Leu Glu Glu Leu Leu Ala Trp Ile Gln Trp
4925 4930 4935 Ala Glu Thr Thr Leu Ile Gln Arg Asp Gln Glu Pro Ile
Pro Gln 4940 4945 4950 Asn Ile Asp Arg Val Lys Ala Leu Ile Ala Glu
His Gln Thr Phe 4955 4960 4965 Met Glu Glu Met Thr Arg Lys Gln Pro
Asp Val Asp Arg Val Thr 4970 4975 4980 Lys Thr Tyr Lys Arg Lys Asn
Ile Glu Pro Thr His Ala Pro Phe 4985 4990 4995 Ile Glu Lys Ser Arg
Ser Gly Gly Arg Lys Ser Leu Ser Gln Pro 5000 5005 5010 Thr Pro Pro
Pro Met Pro Ile Leu Ser Gln Ser Glu Ala Lys Asn 5015 5020 5025 Pro
Arg Ile Asn Gln Leu Ser Ala Arg Trp Gln Gln Val Trp Leu 5030 5035
5040 Leu Ala Leu Glu Arg Gln Arg Lys Leu Asn Asp Ala Leu Asp Arg
5045 5050 5055 Leu Glu Glu Leu Lys Glu Phe Ala Asn Phe Asp Phe Asp
Val Trp 5060 5065 5070 Arg Lys Lys Tyr Met Arg Trp Met Asn His Lys
Lys Ser Arg Val 5075 5080 5085 Met Asp Phe Phe Arg Arg Ile Asp Lys
Asp Gln Asp Gly Lys Ile 5090 5095 5100 Thr Arg Gln Glu Phe Ile Asp
Gly Ile Leu Ala Ser Lys Phe Pro 5105 5110 5115 Thr Thr Lys Leu Glu
Met Thr Ala Val Ala Asp Ile Phe Asp Arg 5120 5125 5130 Asp Gly Asp
Gly Tyr Ile Asp Tyr Tyr Glu Phe Val Ala Ala Leu 5135 5140 5145 His
Pro Asn Lys Asp Ala Tyr Arg Pro Thr Thr Asp Ala Asp Lys 5150 5155
5160 Ile Glu Asp Glu Val Thr Arg Gln Val Ala Gln Cys Lys Cys Ala
5165 5170 5175 Lys Arg Phe Gln Val Glu Gln Ile Gly Glu Asn Lys Tyr
Arg Phe 5180 5185 5190 Gly Asp Ser Gln Gln Leu Arg Leu Val Arg Ile
Leu Arg Ser Thr 5195 5200 5205 Val Met Val Arg Val Gly Gly Gly Trp
Met Ala Leu Asp Glu Phe 5210 5215 5220 Leu Val Lys Asn Asp Pro Cys
Arg Ala Arg Gly Arg Thr Asn Ile 5225 5230 5235 Glu Leu Arg Glu Lys
Phe Ile Leu Pro Glu Gly Ala Ser Gln Gly 5240 5245 5250 Met Thr Pro
Phe Arg Ser Arg Gly Arg Arg Ser Lys Pro Ser Ser 5255 5260 5265 Arg
Ala Ala Ser Pro Thr Arg Ser Ser Ser Ser Ala Ser Gln Ser 5270 5275
5280 Asn His Ser Cys Thr Ser Met Pro Ser Ser Pro Ala Thr Pro Ala
5285 5290 5295 Ser Gly Thr Lys Val Ile Pro Ser Ser Gly Ser Lys Leu
Lys Arg 5300 5305 5310 Pro Thr Pro Thr Phe His Ser Ser Arg Thr Ser
Leu Ala Gly Asp 5315 5320 5325 Thr Ser Asn Ser Ser Ser Pro Ala Ser
Thr Gly Ala Lys Thr Asn 5330 5335 5340 Arg Ala Asp Pro Lys Lys Ser
Ala Ser Arg Pro Gly Ser Arg Ala 5345 5350 5355 Gly Ser Arg Ala Gly
Ser Arg Ala Ser Ser Arg Arg Gly Ser Asp 5360 5365 5370 Ala Ser Asp
Phe Asp Leu Leu Glu Thr Gln Ser Ala Cys Ser Asp 5375 5380 5385 Thr
Ser Glu Ser Ser Ala Ala Gly Gly Gln Gly Asn Ser Arg Arg 5390 5395
5400 Gly Leu Asn Lys Pro Ser Lys Ile Pro Thr Met Ser Lys Lys Thr
5405 5410 5415 Thr Thr Ala Ser Pro Arg Thr Pro Gly Pro Lys Arg 5420
5425 5430 320355PRTHomo sapiens 320Met Ala Lys Leu Ile Ala Leu Thr
Leu Leu Gly Met Gly Leu Ala Leu 1 5 10 15 Phe Arg Asn His Gln Ser
Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 20 25 30 Glu Val Gln Pro
Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 35 40 45 Glu Thr
Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 50 55 60
Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 65
70 75 80 Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp
Pro Thr 85 90 95 Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp
Val Ser Ser Phe 100 105 110 Asn Pro His Gly Ile Ser Thr Phe Thr Asp
Glu Asp Asn Ala Met Tyr 115 120 125 Leu Leu Val Val Asn His Pro Asp
Ala Lys Ser Thr Val Glu Leu Phe 130 135
140 Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg
145 150 155 160 His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val
Gly Pro Glu 165 170 175 His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu
Asp Pro Tyr Leu Gln 180 185 190 Ser Trp Glu Met Tyr Leu Gly Leu Ala
Trp Ser Tyr Val Val Tyr Tyr 195 200 205 Ser Pro Ser Glu Val Arg Val
Val Ala Glu Gly Phe Asp Phe Ala Asn 210 215 220 Gly Ile Asn Ile Ser
Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 225 230 235 240 Leu Ala
His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 245 250 255
Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 260
265 270 Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn
Gly 275 280 285 Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala
Ser Glu Val 290 295 300 Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro
Lys Val Thr Gln Val 305 310 315 320 Tyr Ala Glu Asn Gly Thr Val Leu
Gln Gly Ser Thr Val Ala Ser Val 325 330 335 Tyr Lys Gly Lys Leu Leu
Ile Gly Thr Val Phe His Lys Ala Leu Tyr 340 345 350 Cys Glu Leu 355
321634PRTHomo sapiens 321Met Ala Gln Gly Val Leu Trp Ile Leu Leu
Gly Leu Leu Leu Trp Ser 1 5 10 15 Asp Pro Gly Thr Ala Ser Leu Pro
Leu Leu Met Asp Ser Val Ile Gln 20 25 30 Ala Leu Ala Glu Leu Glu
Gln Lys Val Pro Ala Ala Lys Thr Arg His 35 40 45 Thr Ala Ser Ala
Trp Leu Met Ser Ala Pro Asn Ser Gly Pro His Asn 50 55 60 Arg Leu
Tyr His Phe Leu Leu Gly Ala Trp Ser Leu Asn Ala Thr Glu 65 70 75 80
Leu Asp Pro Cys Pro Leu Ser Pro Glu Leu Leu Gly Leu Thr Lys Glu 85
90 95 Val Ala Arg His Asp Val Arg Glu Gly Lys Glu Tyr Gly Val Val
Leu 100 105 110 Ala Pro Asp Gly Ser Thr Val Ala Val Glu Pro Leu Leu
Ala Gly Leu 115 120 125 Glu Ala Gly Leu Gln Gly Arg Arg Val Ile Asn
Leu Pro Leu Asp Ser 130 135 140 Met Ala Ala Pro Trp Glu Thr Gly Asp
Thr Phe Pro Asp Val Val Ala 145 150 155 160 Ile Ala Pro Asp Val Arg
Ala Thr Ser Ser Pro Gly Leu Arg Asp Gly 165 170 175 Ser Pro Asp Val
Thr Thr Ala Asp Ile Gly Ala Asn Thr Pro Asp Ala 180 185 190 Thr Lys
Gly Cys Pro Asp Val Gln Ala Ser Leu Pro Asp Ala Lys Ala 195 200 205
Lys Ser Pro Pro Thr Met Val Asp Ser Leu Leu Ala Val Thr Leu Ala 210
215 220 Gly Asn Leu Gly Leu Thr Phe Leu Arg Gly Ser Gln Thr Gln Ser
His 225 230 235 240 Pro Asp Leu Gly Thr Glu Gly Cys Trp Asp Gln Leu
Ser Ala Pro Arg 245 250 255 Thr Phe Thr Leu Leu Asp Pro Lys Ala Ser
Leu Leu Thr Met Ala Phe 260 265 270 Leu Asn Gly Ala Leu Asp Gly Val
Ile Leu Gly Asp Tyr Leu Ser Arg 275 280 285 Thr Pro Glu Pro Arg Pro
Ser Leu Ser His Leu Leu Ser Gln Tyr Tyr 290 295 300 Gly Ala Gly Val
Ala Arg Asp Pro Gly Phe Arg Ser Asn Phe Arg Arg 305 310 315 320 Gln
Asn Gly Ala Ala Leu Thr Ser Ala Ser Ile Leu Ala Gln Gln Val 325 330
335 Trp Gly Thr Leu Val Leu Leu Gln Arg Leu Glu Pro Val His Leu Gln
340 345 350 Leu Gln Cys Met Ser Gln Glu Gln Leu Ala Gln Val Ala Ala
Asn Ala 355 360 365 Thr Lys Glu Phe Thr Glu Ala Phe Leu Gly Cys Pro
Ala Ile His Pro 370 375 380 Arg Cys Arg Trp Gly Ala Ala Pro Tyr Arg
Gly Arg Pro Lys Leu Leu 385 390 395 400 Gln Leu Pro Leu Gly Phe Leu
Tyr Val His His Thr Tyr Val Pro Ala 405 410 415 Pro Pro Cys Thr Asp
Phe Thr Arg Cys Ala Ala Asn Met Arg Ser Met 420 425 430 Gln Arg Tyr
His Gln Asp Thr Gln Gly Trp Gly Asp Ile Gly Tyr Gly 435 440 445 Phe
Val Val Gly Ser Asp Gly Tyr Val Tyr Glu Gly Arg Gly Trp His 450 455
460 Trp Val Gly Ala His Thr Leu Gly His Asn Ser Arg Gly Phe Gly Val
465 470 475 480 Ala Ile Val Gly Asn Tyr Thr Ala Ala Leu Pro Thr Glu
Ala Ala Leu 485 490 495 Arg Thr Val Arg Asp Thr Leu Pro Ser Cys Ala
Val Arg Ala Gly Leu 500 505 510 Leu Arg Pro Asp Tyr Ala Leu Leu Gly
His Arg Gln Leu Val Arg Thr 515 520 525 Asp Cys Pro Gly Asp Ala Leu
Phe Asp Leu Leu Arg Thr Trp Pro His 530 535 540 Phe Thr Ala Val Ser
Leu Arg Ser Leu His Tyr Thr Ala Arg Arg Pro 545 550 555 560 Ser Val
Tyr Thr Ser Ser Thr Arg Pro Leu Pro Pro Ala Cys Asn Ser 565 570 575
Cys Ala Arg Thr Ala Ser Ala Arg Pro Pro Thr Ser Arg Arg His Val 580
585 590 Tyr Ser Gly Asn Leu Gly Pro Ala Phe Ala Gly His Ser Ala Gly
Asn 595 600 605 Ile Pro Asp Pro Val Thr Ser Ala Tyr Ala Ala Ser Ala
Gln Pro Gln 610 615 620 Thr Gln Pro Ala Cys Pro Phe Pro Ser Ser 625
630 322638PRTHomo sapiens 322Met Ile Leu Phe Lys Gln Ala Thr Tyr
Phe Ile Ser Leu Phe Ala Thr 1 5 10 15 Val Ser Cys Gly Cys Leu Thr
Gln Leu Tyr Glu Asn Ala Phe Phe Arg 20 25 30 Gly Gly Asp Val Ala
Ser Met Tyr Thr Pro Asn Ala Gln Tyr Cys Gln 35 40 45 Met Arg Cys
Thr Phe His Pro Arg Cys Leu Leu Phe Ser Phe Leu Pro 50 55 60 Ala
Ser Ser Ile Asn Asp Met Glu Lys Arg Phe Gly Cys Phe Leu Lys 65 70
75 80 Asp Ser Val Thr Gly Thr Leu Pro Lys Val His Arg Thr Gly Ala
Val 85 90 95 Ser Gly His Ser Leu Lys Gln Cys Gly His Gln Ile Ser
Ala Cys His 100 105 110 Arg Asp Ile Tyr Lys Gly Val Asp Met Arg Gly
Val Asn Phe Asn Val 115 120 125 Ser Lys Val Ser Ser Val Glu Glu Cys
Gln Lys Arg Cys Thr Asn Asn 130 135 140 Ile Arg Cys Gln Phe Phe Ser
Tyr Ala Thr Gln Thr Phe His Lys Ala 145 150 155 160 Glu Tyr Arg Asn
Asn Cys Leu Leu Lys Tyr Ser Pro Gly Gly Thr Pro 165 170 175 Thr Ala
Ile Lys Val Leu Ser Asn Val Glu Ser Gly Phe Ser Leu Lys 180 185 190
Pro Cys Ala Leu Ser Glu Ile Gly Cys His Met Asn Ile Phe Gln His 195
200 205 Leu Ala Phe Ser Asp Val Asp Val Ala Arg Val Leu Thr Pro Asp
Ala 210 215 220 Phe Val Cys Arg Thr Ile Cys Thr Tyr His Pro Asn Cys
Leu Phe Phe 225 230 235 240 Thr Phe Tyr Thr Asn Val Trp Lys Ile Glu
Ser Gln Arg Asn Val Cys 245 250 255 Leu Leu Lys Thr Ser Glu Ser Gly
Thr Pro Ser Ser Ser Thr Pro Gln 260 265 270 Glu Asn Thr Ile Ser Gly
Tyr Ser Leu Leu Thr Cys Lys Arg Thr Leu 275 280 285 Pro Glu Pro Cys
His Ser Lys Ile Tyr Pro Gly Val Asp Phe Gly Gly 290 295 300 Glu Glu
Leu Asn Val Thr Phe Val Lys Gly Val Asn Val Cys Gln Glu 305 310 315
320 Thr Cys Thr Lys Met Ile Arg Cys Gln Phe Phe Thr Tyr Ser Leu Leu
325 330 335 Pro Glu Asp Cys Lys Glu Glu Lys Cys Lys Cys Phe Leu Arg
Leu Ser 340 345 350 Met Asp Gly Ser Pro Thr Arg Ile Ala Tyr Gly Thr
Gln Gly Ser Ser 355 360 365 Gly Tyr Ser Leu Arg Leu Cys Asn Thr Gly
Asp Asn Ser Val Cys Thr 370 375 380 Thr Lys Thr Ser Thr Arg Ile Val
Gly Gly Thr Asn Ser Ser Trp Gly 385 390 395 400 Glu Trp Pro Trp Gln
Val Ser Leu Gln Val Lys Leu Thr Ala Gln Arg 405 410 415 His Leu Cys
Gly Gly Ser Leu Ile Gly His Gln Trp Val Leu Thr Ala 420 425 430 Ala
His Cys Phe Asp Gly Leu Pro Leu Gln Asp Val Trp Arg Ile Tyr 435 440
445 Ser Gly Ile Leu Asn Leu Ser Asp Ile Thr Lys Asp Thr Pro Phe Ser
450 455 460 Gln Ile Lys Glu Ile Ile Ile His Gln Asn Tyr Lys Val Ser
Glu Gly 465 470 475 480 Asn His Asp Ile Ala Leu Ile Lys Leu Gln Ala
Pro Leu Asn Tyr Thr 485 490 495 Glu Phe Gln Lys Pro Ile Cys Leu Pro
Ser Lys Gly Asp Thr Ser Thr 500 505 510 Ile Tyr Thr Asn Cys Trp Val
Thr Gly Trp Gly Phe Ser Lys Glu Lys 515 520 525 Gly Glu Ile Gln Asn
Ile Leu Gln Lys Val Asn Ile Pro Leu Val Thr 530 535 540 Asn Glu Glu
Cys Gln Lys Arg Tyr Gln Asp Tyr Lys Ile Thr Gln Arg 545 550 555 560
Met Val Cys Ala Gly Tyr Lys Glu Gly Gly Lys Asp Ala Cys Lys Gly 565
570 575 Asp Ser Gly Gly Pro Leu Val Cys Lys His Asn Gly Met Trp Arg
Leu 580 585 590 Val Gly Ile Thr Ser Trp Gly Glu Gly Cys Ala Arg Arg
Glu Gln Pro 595 600 605 Gly Val Tyr Thr Lys Val Ala Glu Tyr Met Asp
Trp Ile Leu Glu Lys 610 615 620 Thr Gln Ser Ser Asp Gly Lys Ala Gln
Met Gln Ser Pro Ala 625 630 635 323810PRTHomo sapiens 323Met Glu
His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 1 5 10 15
Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 20
25 30 Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu
Glu 35 40 45 Cys Ala Ala Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys
Arg Ala Phe 50 55 60 Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile
Met Ala Glu Asn Arg 65 70 75 80 Lys Ser Ser Ile Ile Ile Arg Met Arg
Asp Val Val Leu Phe Glu Lys 85 90 95 Lys Val Tyr Leu Ser Glu Cys
Lys Thr Gly Asn Gly Lys Asn Tyr Arg 100 105 110 Gly Thr Met Ser Lys
Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 115 120 125 Ser Thr Ser
Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser 130 135 140 Glu
Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln 145 150
155 160 Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr
Cys 165 170 175 Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser
Gly Glu Asn 180 185 190 Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly
Leu Glu Cys Gln Ala 195 200 205 Trp Asp Ser Gln Ser Pro His Ala His
Gly Tyr Ile Pro Ser Lys Phe 210 215 220 Pro Asn Lys Asn Leu Lys Lys
Asn Tyr Cys Arg Asn Pro Asp Arg Glu 225 230 235 240 Leu Arg Pro Trp
Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 245 250 255 Cys Asp
Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 260 265 270
Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 275
280 285 Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr
Pro 290 295 300 His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys
Asn Leu Asp 305 310 315 320 Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys
Arg Ala Pro Trp Cys His 325 330 335 Thr Thr Asn Ser Gln Val Arg Trp
Glu Tyr Cys Lys Ile Pro Ser Cys 340 345 350 Asp Ser Ser Pro Val Ser
Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro 355 360 365 Glu Leu Thr Pro
Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 370 375 380 Tyr Arg
Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 385 390 395
400 Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr
405 410 415 Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp
Ala Asp 420 425 430 Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val
Arg Trp Glu Tyr 435 440 445 Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu
Ala Ser Val Val Ala Pro 450 455 460 Pro Pro Val Val Leu Leu Pro Asp
Val Glu Thr Pro Ser Glu Glu Asp 465 470 475 480 Cys Met Phe Gly Asn
Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr 485 490 495 Val Thr Gly
Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg 500 505 510 His
Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys 515 520
525 Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr
530 535 540 Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro
Gln Cys 545 550 555 560 Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln
Val Glu Pro Lys Lys 565 570 575 Cys Pro Gly Arg Val Val Gly Gly Cys
Val Ala His Pro His Ser Trp 580 585 590 Pro Trp Gln Val Ser Leu Arg
Thr Arg Phe Gly Met His Phe Cys Gly 595 600 605 Gly Thr Leu Ile Ser
Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu 610 615 620 Glu Lys Ser
Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His 625 630 635 640
Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg 645
650 655 Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu
Ser 660 665 670 Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys
Leu Pro Ser 675 680 685 Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys
Phe Ile Thr Gly Trp 690 695 700 Gly Glu Thr Gln Gly Thr Phe Gly Ala
Gly Leu Leu Lys Glu Ala Gln 705 710 715 720 Leu Pro Val Ile Glu Asn
Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn 725 730 735 Gly Arg Val Gln
Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly 740 745 750 Thr Asp
Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu 755 760 765
Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys 770
775 780 Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe
Val 785 790 795 800 Thr Trp Ile Glu Gly Val Met Arg Asn Asn 805 810
324722PRTHomo
sapiens 324Met Ser Gln Gln Asp Ala Val Ala Ala Leu Ser Glu Arg Leu
Leu Val 1 5 10 15 Ala Ala Tyr Lys Gly Gln Thr Glu Asn Val Val Gln
Leu Ile Asn Lys 20 25 30 Gly Ala Arg Val Ala Val Thr Lys His Gly
Arg Thr Pro Leu His Leu 35 40 45 Ala Ala Asn Lys Gly His Leu Pro
Val Val Gln Ile Leu Leu Lys Ala 50 55 60 Gly Cys Asp Leu Asp Val
Gln Asp Asp Gly Asp Gln Thr Ala Leu His 65 70 75 80 Arg Ala Thr Val
Val Gly Asn Thr Glu Ile Ile Ala Ala Leu Ile His 85 90 95 Glu Gly
Cys Ala Leu Asp Arg Gln Asp Lys Asp Gly Asn Thr Ala Leu 100 105 110
His Glu Ala Ser Trp His Gly Phe Ser Gln Ser Ala Lys Leu Leu Ile 115
120 125 Lys Ala Gly Ala Asn Val Leu Ala Lys Asn Lys Ala Gly Asn Thr
Ala 130 135 140 Leu His Leu Ala Cys Gln Asn Ser His Ser Gln Ser Thr
Arg Val Leu 145 150 155 160 Leu Leu Ala Gly Ser Arg Ala Asp Leu Lys
Asn Asn Ala Gly Asp Thr 165 170 175 Cys Leu His Val Ala Ala Arg Tyr
Asn His Leu Ser Ile Ile Arg Leu 180 185 190 Leu Leu Thr Ala Phe Cys
Ser Val His Glu Lys Asn Gln Ala Gly Asp 195 200 205 Thr Ala Leu His
Val Ala Ala Ala Leu Asn His Lys Lys Val Ala Lys 210 215 220 Ile Leu
Leu Glu Ala Gly Ala Asp Thr Thr Ile Val Asn Asn Ala Gly 225 230 235
240 Gln Thr Pro Leu Glu Thr Ala Arg Tyr His Asn Asn Pro Glu Val Ala
245 250 255 Leu Leu Leu Thr Lys Ala Pro Gln Val Leu Arg Phe Ser Arg
Gly Arg 260 265 270 Ser Leu Arg Lys Lys Arg Glu Arg Leu Lys Glu Glu
Arg Arg Ala Gln 275 280 285 Ser Val Pro Arg Asp Glu Val Ala Gln Ser
Lys Gly Ser Val Ser Ala 290 295 300 Gly Asp Thr Pro Ser Ser Glu Gln
Ala Val Ala Arg Lys Glu Glu Ala 305 310 315 320 Arg Glu Glu Phe Leu
Ser Ala Ser Pro Glu Pro Arg Ala Lys Asp Asp 325 330 335 Arg Arg Arg
Lys Ser Arg Pro Lys Val Ser Ala Phe Ser Asp Pro Thr 340 345 350 Pro
Pro Ala Asp Gln Gln Pro Gly His Gln Lys Asn Leu His Ala His 355 360
365 Asn His Pro Lys Lys Arg Asn Arg His Arg Cys Ser Ser Pro Pro Pro
370 375 380 Pro His Glu Phe Arg Ala Tyr Gln Leu Tyr Thr Leu Tyr Arg
Gly Lys 385 390 395 400 Asp Gly Lys Val Met Gln Ala Pro Ile Asn Gly
Cys Arg Cys Glu Pro 405 410 415 Leu Ile Asn Lys Leu Glu Asn Gln Leu
Glu Ala Thr Val Glu Glu Ile 420 425 430 Lys Ala Glu Leu Gly Ser Val
Gln Asp Lys Met Asn Thr Lys Leu Gly 435 440 445 Gln Met Glu Asn Lys
Thr Gln His Gln Met Arg Val Leu Asp Lys Leu 450 455 460 Met Val Glu
Arg Leu Ser Ala Glu Arg Thr Glu Cys Leu Asn Arg Leu 465 470 475 480
Gln Gln His Ser Asp Thr Glu Lys His Glu Gly Glu Lys Arg Gln Ile 485
490 495 Ser Leu Val Asp Glu Leu Lys Thr Trp Cys Met Leu Lys Ile Gln
Asn 500 505 510 Leu Glu Gln Lys Leu Ser Gly Asp Ser Arg Ala Cys Arg
Ala Lys Ser 515 520 525 Thr Pro Ser Thr Cys Val Asp Gln Leu Val Val
Thr Ala Gly Pro Ala 530 535 540 Ala Ala Ser Asp Ser Ser Pro Pro Val
Val Arg Pro Lys Glu Lys Ala 545 550 555 560 Leu Asn Ser Thr Ala Thr
Gln Arg Leu Gln Gln Glu Leu Ser Ser Ser 565 570 575 Asp Cys Thr Gly
Ser Arg Leu Arg Asn Val Lys Val Gln Thr Ala Leu 580 585 590 Leu Pro
Met Asn Glu Ala Ala Arg Ser Asp Gln Gln Ala Gly Pro Cys 595 600 605
Val Asn Arg Gly Thr Gln Thr Lys Lys Ser Gly Lys Ser Gly Pro Thr 610
615 620 Arg His Arg Ala Gln Gln Pro Ala Ala Ser Ser Thr Cys Gly Gln
Pro 625 630 635 640 Pro Pro Ala Thr Gly Ser Glu Gln Thr Gly Pro His
Ile Arg Asp Thr 645 650 655 Ser Gln Ala Leu Glu Leu Thr Gln Tyr Phe
Phe Glu Ala Val Ser Thr 660 665 670 Gln Met Glu Lys Trp Tyr Glu Arg
Lys Ile Glu Glu Ala Arg Ser Gln 675 680 685 Ala Asn Gln Lys Ala Gln
Gln Asp Lys Ala Thr Leu Lys Glu His Ile 690 695 700 Lys Ser Leu Glu
Glu Glu Leu Ala Lys Leu Arg Thr Arg Val Gln Lys 705 710 715 720 Glu
Asn 32594PRTHomo sapiens 325Met Glu Lys Glu Ser Leu Pro Arg Ser Leu
Asn Phe Asp His His Gly 1 5 10 15 Ile Tyr Met Asn Trp Gln Thr Lys
Phe Met Leu Leu Leu Lys Thr Val 20 25 30 Ser Ile Pro Arg Ser Gln
Ala Ile Phe Thr Gln Pro Gly Leu Gly Ser 35 40 45 Gly Thr Pro Gln
Gly Tyr Lys Gln Ser His Ser Ala Leu Gly Trp Ala 50 55 60 Ala Thr
Leu Ser Cys Trp Gly Lys Asp Gly Ser Arg Gln Leu Ser Trp 65 70 75 80
Val Thr Ala Gly Ser Ser Phe His Lys Ser Asp Leu Ile Ser 85 90
326790PRTHomo sapiens 326Met Asn Ile Met Asn Thr Glu Gln Ser Gln
Asn Ser Ile Val Ser Arg 1 5 10 15 Ile Lys Val Phe Glu Gly Gln Thr
Asn Ile Glu Thr Ser Gly Leu Pro 20 25 30 Lys Lys Pro Glu Ile Thr
Pro Arg Ser Leu Pro Pro Lys Pro Thr Val 35 40 45 Ser Ser Gly Lys
Pro Ser Val Ala Pro Lys Pro Ala Ala Asn Arg Ala 50 55 60 Ser Gly
Glu Trp Asp Ser Gly Thr Glu Asn Arg Leu Lys Val Thr Ser 65 70 75 80
Lys Glu Gly Leu Thr Pro Tyr Pro Pro Leu Gln Glu Ala Gly Ser Ile 85
90 95 Pro Val Thr Lys Pro Glu Leu Pro Lys Lys Pro Asn Pro Gly Leu
Ile 100 105 110 Arg Ser Val Asn Pro Glu Ile Pro Gly Arg Gly Pro Leu
Ala Glu Ser 115 120 125 Ser Asp Ser Gly Lys Lys Val Pro Thr Pro Ala
Pro Arg Pro Leu Leu 130 135 140 Leu Lys Lys Ser Val Ser Ser Glu Asn
Pro Thr Tyr Pro Ser Ala Pro 145 150 155 160 Leu Lys Pro Val Thr Val
Pro Pro Arg Leu Ala Gly Ala Ser Gln Ala 165 170 175 Lys Ala Tyr Lys
Ser Leu Gly Glu Gly Pro Pro Ala Asn Pro Pro Val 180 185 190 Pro Val
Leu Gln Ser Lys Pro Leu Val Asp Ile Asp Leu Ile Ser Phe 195 200 205
Asp Asp Asp Val Leu Pro Thr Pro Ser Gly Asn Leu Ala Glu Glu Ser 210
215 220 Val Gly Ser Glu Met Val Leu Asp Pro Phe Gln Leu Pro Ala Lys
Thr 225 230 235 240 Glu Pro Ile Lys Glu Arg Ala Val Gln Pro Ala Pro
Thr Arg Lys Pro 245 250 255 Thr Val Ile Arg Ile Pro Ala Lys Pro Gly
Lys Cys Leu His Glu Asp 260 265 270 Pro Gln Ser Pro Pro Pro Leu Pro
Ala Glu Lys Pro Ile Gly Asn Thr 275 280 285 Phe Ser Thr Val Ser Gly
Lys Leu Ser Asn Val Glu Arg Thr Arg Asn 290 295 300 Leu Glu Ser Asn
His Pro Gly Gln Thr Gly Gly Phe Val Arg Val Pro 305 310 315 320 Pro
Arg Leu Pro Pro Arg Pro Val Asn Gly Lys Thr Ile Pro Thr Gln 325 330
335 Gln Pro Pro Thr Lys Val Pro Pro Glu Arg Pro Pro Pro Pro Lys Leu
340 345 350 Ser Ala Thr Arg Arg Ser Asn Lys Lys Leu Pro Phe Asn Arg
Ser Ser 355 360 365 Ser Asp Met Asp Leu Gln Lys Lys Gln Ser Asn Leu
Ala Thr Gly Leu 370 375 380 Ser Lys Ala Lys Ser Gln Val Phe Lys Asn
Gln Asp Pro Val Leu Pro 385 390 395 400 Pro Arg Pro Lys Pro Gly His
Pro Leu Tyr Ser Lys Tyr Met Leu Ser 405 410 415 Val Pro His Gly Ile
Ala Asn Glu Asp Ile Val Ser Gln Asn Pro Gly 420 425 430 Glu Leu Ser
Cys Lys Arg Gly Asp Val Leu Val Met Leu Lys Gln Thr 435 440 445 Glu
Asn Asn Tyr Leu Glu Cys Gln Lys Gly Glu Asp Thr Gly Arg Val 450 455
460 His Leu Ser Gln Met Lys Ile Ile Thr Pro Leu Asp Glu His Leu Arg
465 470 475 480 Ser Arg Pro Asn Asp Pro Ser His Ala Gln Lys Pro Val
Asp Ser Gly 485 490 495 Ala Pro His Ala Val Val Leu His Asp Phe Pro
Ala Glu Gln Val Asp 500 505 510 Asp Leu Asn Leu Thr Ser Gly Glu Ile
Val Tyr Leu Leu Glu Lys Ile 515 520 525 Asp Thr Asp Trp Tyr Arg Gly
Asn Cys Arg Asn Gln Ile Gly Ile Phe 530 535 540 Pro Ala Asn Tyr Val
Lys Val Ile Ile Asp Ile Pro Glu Gly Gly Asn 545 550 555 560 Gly Lys
Arg Glu Cys Val Ser Ser His Cys Val Lys Gly Ser Arg Cys 565 570 575
Val Ala Arg Phe Glu Tyr Ile Gly Glu Gln Lys Asp Glu Leu Ser Phe 580
585 590 Ser Glu Gly Glu Ile Ile Ile Leu Lys Glu Tyr Val Asn Glu Glu
Trp 595 600 605 Ala Arg Gly Glu Val Arg Gly Arg Thr Gly Ile Phe Pro
Leu Asn Phe 610 615 620 Val Glu Pro Val Glu Asp Tyr Pro Thr Ser Gly
Ala Asn Val Leu Ser 625 630 635 640 Thr Lys Val Pro Leu Lys Thr Lys
Lys Glu Asp Ser Gly Ser Asn Ser 645 650 655 Gln Val Asn Ser Leu Pro
Ala Glu Trp Cys Glu Ala Leu His Ser Phe 660 665 670 Thr Ala Glu Thr
Ser Asp Asp Leu Ser Phe Lys Arg Gly Asp Arg Ile 675 680 685 Gln Ile
Leu Glu Arg Leu Asp Ser Asp Trp Cys Arg Gly Arg Leu Gln 690 695 700
Asp Arg Glu Gly Ile Phe Pro Ala Val Phe Val Arg Pro Cys Pro Ala 705
710 715 720 Glu Ala Lys Ser Met Leu Ala Ile Val Pro Lys Gly Arg Lys
Ala Lys 725 730 735 Ala Leu Tyr Asp Phe Arg Gly Glu Asn Glu Asp Glu
Leu Ser Phe Lys 740 745 750 Ala Gly Asp Ile Ile Thr Glu Leu Glu Ser
Val Asp Asp Asp Trp Met 755 760 765 Ser Gly Glu Leu Met Gly Lys Ser
Gly Ile Phe Pro Lys Asn Tyr Ile 770 775 780 Gln Phe Leu Gln Ile Ser
785 790 327593PRTHomo sapiens 327Met Gly Gly Val Gln Gly His Phe
Val Ile Phe Arg Gly Leu Ala Lys 1 5 10 15 Ala Leu Ser Arg Pro Val
Thr Leu Ala Thr Pro Asp Ser Ser Leu Leu 20 25 30 Leu Arg Lys Thr
Gly Gln Pro Gly Ala Thr Arg Ser Ala Leu Thr Lys 35 40 45 Met Leu
Pro Gly Ala Trp Leu Leu Trp Thr Ser Leu Leu Leu Leu Ala 50 55 60
Arg Pro Ala Gln Pro Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu 65
70 75 80 Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp
Ile Pro 85 90 95 Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr Ser
Phe Thr Thr Leu 100 105 110 Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn
Leu Thr Lys Val Val Phe 115 120 125 Leu Asn Thr Gln Leu Cys Gln Phe
Arg Pro Asp Ala Phe Gly Gly Leu 130 135 140 Pro Arg Leu Glu Asp Leu
Glu Val Thr Gly Ser Ser Phe Leu Asn Leu 145 150 155 160 Ser Thr Asn
Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu 165 170 175 Asn
Phe Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu 180 185
190 Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu
195 200 205 Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu
Asn Leu 210 215 220 Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu
Phe His Pro Leu 225 230 235 240 Thr Ser Leu Gln Thr Leu Lys Leu Ser
Asn Asn Ala Leu Ser Gly Leu 245 250 255 Pro Gln Gly Val Phe Gly Lys
Leu Gly Ser Leu Gln Glu Leu Phe Leu 260 265 270 Asp Ser Asn Asn Ile
Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu 275 280 285 Phe Cys Leu
Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu 290 295 300 Pro
Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu 305 310
315 320 Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His
Thr 325 330 335 Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu
Glu Thr Val 340 345 350 Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu
Arg Ser Leu Met Leu 355 360 365 Ser Tyr Asn Ala Ile Thr His Leu Pro
Ala Gly Ile Phe Arg Asp Leu 370 375 380 Glu Glu Leu Val Lys Leu Tyr
Leu Gly Ser Asn Asn Leu Thr Ala Leu 385 390 395 400 His Pro Ala Leu
Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu 405 410 415 Ser Lys
Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn 420 425 430
Tyr Asn Leu Phe Asn Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp 435
440 445 Cys His Leu Ala Tyr Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp
Arg 450 455 460 Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro Ala Tyr
Leu Lys Gly 465 470 475 480 Gln Val Val Pro Ala Leu Asn Glu Lys Gln
Leu Val Cys Pro Val Thr 485 490 495 Arg Asp His Leu Gly Phe Gln Val
Thr Trp Pro Asp Glu Ser Lys Ala 500 505 510 Gly Gly Ser Trp Asp Leu
Ala Val Gln Glu Arg Ala Ala Arg Ser Gln 515 520 525 Cys Thr Tyr Ser
Asn Pro Glu Gly Thr Val Val Leu Ala Cys Asp Gln 530 535 540 Ala Gln
Cys Arg Trp Leu Asn Val Gln Leu Ser Pro Trp Gln Gly Ser 545 550 555
560 Leu Gly Leu Gln Tyr Asn Ala Ser Gln Glu Trp Asp Leu Arg Ser Ser
565 570 575 Cys Gly Ser Leu Arg Leu Thr Val Ser Ile Glu Ala Arg Ala
Ala Gly 580 585 590 Pro 328210PRTHomo
sapiensmisc_feature(95)..(95)Xaa can be any naturally occurring
amino acidmisc_feature(180)..(180)Xaa can be any naturally
occurring amino acid 328Met Asp Asp Asp Asp Asn Lys Asp Asn Ala Ile
Leu Glu Asn Asp Ser 1 5 10 15 Arg Thr Trp Ser Lys Asp Leu Gln Asn
Val Asn Ile Thr Leu His Ile 20 25 30 Pro Phe Gln Pro Val Ala Ser
Gln Leu Pro Arg Ile Phe Thr Ser Ile 35 40 45 Gly Glu Asp Tyr Asp
Glu Pro Val Leu Pro Ser Ile Thr Thr Glu Met 50 55 60 Leu Lys Ser
Val Val Val Cys Phe Asp Ala Gly Glu Leu Ile Thr Gln 65 70
75 80 Arg Glu Leu Val Ser Arg Gln Val Ser Asp Asn Leu Thr Glu Xaa
Ala 85 90 95 Ala Thr Phe Arg Leu Ile Leu Asp Asp Val Ser Leu Thr
Tyr Leu Thr 100 105 110 Phe Arg Lys Asp Phe Thr Glu Ala Val Gly Ala
Lys Gln Val Ala Gln 115 120 125 Gln Glu Ala Glu Arg Ala Arg Phe Val
Met Glu Lys Ala Lys Gln Gln 130 135 140 Lys Lys Ala Ala Ile Ile Ser
Ala Glu Gly Asp Ser Lys Ala Ala Glu 145 150 155 160 Leu Ile Ala Asn
Ser Leu Ala Thr Ala Gly Asp Gly Leu Ile Glu Leu 165 170 175 Arg Lys
Leu Xaa Ala Ala Glu Asp Ile Ala Tyr Gln Leu Ser Arg Ser 180 185 190
Gln Asn Ile Thr Tyr Leu Pro Ala Gly Gln Ser Val Leu Leu Gln Leu 195
200 205 Pro Gln 210 329374PRTHomo sapiens 329Met Ala Pro Ala Lys
Asn Ser Gly Lys Lys Lys Met Asp His Ser Ala 1 5 10 15 Ile Asn Glu
Val Met Thr Gln Glu Tyr Thr Asn Ile His Lys His Ile 20 25 30 His
Arg Val Gly Phe Lys Lys His Val Pro Gln Ala Leu Lys Glu Ile 35 40
45 Arg Lys Phe Cys Asn Glu Gly Asp Gly Asn Ser Arg Ser Thr Glu Gln
50 55 60 Val Leu Leu Gln Gly Ala Thr Met Ala Asp Lys Ser Lys Phe
Ile Glu 65 70 75 80 Tyr Ile Asp Glu Ala Leu Glu Lys Ser Lys Glu Thr
Ala Leu Ser His 85 90 95 Leu Phe Phe Thr Tyr Gln Gly Ile Pro Tyr
Pro Ile Thr Met Cys Thr 100 105 110 Ser Glu Thr Phe Gln Ala Leu Asp
Thr Phe Glu Ala Arg His Asp Asp 115 120 125 Ile Val Leu Ala Ser Tyr
Pro Lys Cys Gly Ser Asn Trp Ile Leu His 130 135 140 Ile Val Ser Glu
Leu Ile Tyr Ala Val Ser Lys Lys Lys Tyr Lys Tyr 145 150 155 160 Pro
Glu Phe Pro Val Leu Glu Cys Gly Asp Ser Glu Lys Tyr Gln Arg 165 170
175 Met Lys Gly Phe Pro Ser Pro Arg Ile Leu Ala Thr His Leu His Tyr
180 185 190 Asp Lys Leu Pro Gly Ser Ile Phe Glu Asn Lys Ala Lys Ile
Leu Val 195 200 205 Ile Phe Arg Asn Pro Lys Asp Thr Ala Val Ser Phe
Leu His Phe His 210 215 220 Asn Asp Val Pro Asp Ile Pro Ser Tyr Gly
Ser Trp Asp Glu Phe Phe 225 230 235 240 Arg Gln Phe Met Lys Gly Gln
Val Ser Trp Gly Arg Tyr Phe Asp Phe 245 250 255 Ala Ile Asn Trp Asn
Lys His Leu Asp Gly Asp Asn Val Lys Phe Ile 260 265 270 Leu Tyr Glu
Asp Leu Lys Glu Asn Leu Ala Ala Gly Ile Lys Gln Ile 275 280 285 Ala
Glu Phe Leu Gly Phe Phe Leu Thr Gly Glu Gln Ile Gln Thr Ile 290 295
300 Ser Val Gln Ser Thr Phe Gln Ala Met Arg Ala Lys Ser Gln Asp Thr
305 310 315 320 His Gly Ala Val Gly Pro Phe Leu Phe Arg Lys Gly Glu
Val Gly Asp 325 330 335 Trp Lys Asn Leu Phe Ser Glu Ile Gln Asn Gln
Glu Met Asp Glu Lys 340 345 350 Phe Lys Glu Cys Leu Ala Gly Thr Ser
Leu Gly Ala Lys Leu Lys Tyr 355 360 365 Glu Ser Tyr Cys Gln Gly 370
330676PRTHomo sapiens 330Met Arg Val Leu Gly Gly Arg Cys Gly Ala
Pro Leu Ala Cys Leu Leu 1 5 10 15 Leu Val Leu Pro Val Ser Glu Ala
Asn Leu Leu Ser Lys Gln Gln Ala 20 25 30 Ser Gln Val Leu Val Arg
Lys Arg Arg Ala Asn Ser Leu Leu Glu Glu 35 40 45 Thr Lys Gln Gly
Asn Leu Glu Arg Glu Cys Ile Glu Glu Leu Cys Asn 50 55 60 Lys Glu
Glu Ala Arg Glu Val Phe Glu Asn Asp Pro Glu Thr Asp Tyr 65 70 75 80
Phe Tyr Pro Lys Tyr Leu Val Cys Leu Arg Ser Phe Gln Thr Gly Leu 85
90 95 Phe Thr Ala Ala Arg Gln Ser Thr Asn Ala Tyr Pro Asp Leu Arg
Ser 100 105 110 Cys Val Asn Ala Ile Pro Asp Gln Cys Ser Pro Leu Pro
Cys Asn Glu 115 120 125 Asp Gly Tyr Met Ser Cys Lys Asp Gly Lys Ala
Ser Phe Thr Cys Thr 130 135 140 Cys Lys Pro Gly Trp Gln Gly Glu Lys
Cys Glu Phe Asp Ile Asn Glu 145 150 155 160 Cys Lys Asp Pro Ser Asn
Ile Asn Gly Gly Cys Ser Gln Ile Cys Asp 165 170 175 Asn Thr Pro Gly
Ser Tyr His Cys Ser Cys Lys Asn Gly Phe Val Met 180 185 190 Leu Ser
Asn Lys Lys Asp Cys Lys Asp Val Asp Glu Cys Ser Leu Lys 195 200 205
Pro Ser Ile Cys Gly Thr Ala Val Cys Lys Asn Ile Pro Gly Asp Phe 210
215 220 Glu Cys Glu Cys Pro Glu Gly Tyr Arg Tyr Asn Leu Lys Ser Lys
Ser 225 230 235 240 Cys Glu Asp Ile Asp Glu Cys Ser Glu Asn Met Cys
Ala Gln Leu Cys 245 250 255 Val Asn Tyr Pro Gly Gly Tyr Thr Cys Tyr
Cys Asp Gly Lys Lys Gly 260 265 270 Phe Lys Leu Ala Gln Asp Gln Lys
Ser Cys Glu Val Val Ser Val Cys 275 280 285 Leu Pro Leu Asn Leu Asp
Thr Lys Tyr Glu Leu Leu Tyr Leu Ala Glu 290 295 300 Gln Phe Ala Gly
Val Val Leu Tyr Leu Lys Phe Arg Leu Pro Glu Ile 305 310 315 320 Ser
Arg Phe Ser Ala Glu Phe Asp Phe Arg Thr Tyr Asp Ser Glu Gly 325 330
335 Val Ile Leu Tyr Ala Glu Ser Ile Asp His Ser Ala Trp Leu Leu Ile
340 345 350 Ala Leu Arg Gly Gly Lys Ile Glu Val Gln Leu Lys Asn Glu
His Thr 355 360 365 Ser Lys Ile Thr Thr Gly Gly Asp Val Ile Asn Asn
Gly Leu Trp Asn 370 375 380 Met Val Ser Val Glu Glu Leu Glu His Ser
Ile Ser Ile Lys Ile Ala 385 390 395 400 Lys Glu Ala Val Met Asp Ile
Asn Lys Pro Gly Pro Leu Phe Lys Pro 405 410 415 Glu Asn Gly Leu Leu
Glu Thr Lys Val Tyr Phe Ala Gly Phe Pro Arg 420 425 430 Lys Val Glu
Ser Glu Leu Ile Lys Pro Ile Asn Pro Arg Leu Asp Gly 435 440 445 Cys
Ile Arg Ser Trp Asn Leu Met Lys Gln Gly Ala Ser Gly Ile Lys 450 455
460 Glu Ile Ile Gln Glu Lys Gln Asn Lys His Cys Leu Val Thr Val Glu
465 470 475 480 Lys Gly Ser Tyr Tyr Pro Gly Ser Gly Ile Ala Gln Phe
His Ile Asp 485 490 495 Tyr Asn Asn Val Ser Ser Ala Glu Gly Trp His
Val Asn Val Thr Leu 500 505 510 Asn Ile Arg Pro Ser Thr Gly Thr Gly
Val Met Leu Ala Leu Val Ser 515 520 525 Gly Asn Asn Thr Val Pro Phe
Ala Val Ser Leu Val Asp Ser Thr Ser 530 535 540 Glu Lys Ser Gln Asp
Ile Leu Leu Ser Val Glu Asn Thr Val Ile Tyr 545 550 555 560 Arg Ile
Gln Ala Leu Ser Leu Cys Ser Asp Gln Gln Ser His Leu Glu 565 570 575
Phe Arg Val Asn Arg Asn Asn Leu Glu Leu Ser Thr Pro Leu Lys Ile 580
585 590 Glu Thr Ile Ser His Glu Asp Leu Gln Arg Gln Leu Ala Val Leu
Asp 595 600 605 Lys Ala Met Lys Ala Lys Val Ala Thr Tyr Leu Gly Gly
Leu Pro Asp 610 615 620 Val Pro Phe Ser Ala Thr Pro Val Asn Ala Phe
Tyr Asn Gly Cys Met 625 630 635 640 Glu Val Asn Ile Asn Gly Val Gln
Leu Asp Leu Asp Glu Ala Ile Ser 645 650 655 Lys His Asn Asp Ile Arg
Ala His Ser Cys Pro Ser Val Trp Lys Lys 660 665 670 Thr Lys Asn Ser
675 331747PRTHomo sapiens 331Met Arg Arg Cys Asn Ser Gly Ser Gly
Pro Pro Pro Ser Leu Leu Leu 1 5 10 15 Leu Leu Leu Trp Leu Leu Ala
Val Pro Gly Ala Asn Ala Ala Pro Arg 20 25 30 Ser Ala Leu Tyr Ser
Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 35 40 45 Thr Val Arg
Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 50 55 60 Phe
Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 65 70
75 80 Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr
Leu 85 90 95 Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val
Cys Arg Asp 100 105 110 Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe
Phe Lys Ala Phe Thr 115 120 125 Lys Asn Gly Ser Gly Ala Val Phe Pro
Val Ala Gly Ala Asp Val Gln 130 135 140 Thr Leu Arg Glu Arg Leu Ile
Asp Ala Leu Glu Ser His His Asp Thr 145 150 155 160 Trp Pro Pro Ala
Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 165 170 175 Asp Gly
Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 180 185 190
Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 195
200 205 Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala
Asn 210 215 220 Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys
Tyr Leu Leu 225 230 235 240 Phe Arg Asn Gly Ser Val Ser Arg Val Pro
Val Leu Met Glu Ser Arg 245 250 255 Ser Phe Tyr Thr Ala Tyr Leu Gln
Arg Leu Ser Gly Leu Thr Arg Glu 260 265 270 Ala Ala Gln Thr Thr Val
Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 275 280 285 Thr Val Trp Lys
Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 290 295 300 Glu Ser
Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 305 310 315
320 Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val
325 330 335 Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe
Leu His 340 345 350 Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn
Lys Ile Pro Tyr 355 360 365 Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg
Lys Glu Gly Ala Val Leu 370 375 380 Ala Lys Lys Val Asn Trp Ile Gly
Cys Gln Gly Ser Glu Pro His Phe 385 390 395 400 Arg Gly Phe Pro Cys
Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 405 410 415 Gln Ala Ala
Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 420 425 430 Lys
Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 435 440
445 Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met
450 455 460 His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp
Ser Ser 465 470 475 480 His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala
Pro Ser Glu Asp Pro 485 490 495 Gln Phe Pro Lys Val Gln Trp Pro Pro
Arg Glu Leu Cys Ser Ala Cys 500 505 510 His Asn Glu Arg Leu Asp Val
Pro Val Trp Asp Val Glu Ala Thr Leu 515 520 525 Asn Phe Leu Lys Ala
His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 530 535 540 Pro Ala Ala
Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 545 550 555 560
Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 565
570 575 Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn
Thr 580 585 590 Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg
Pro Pro Lys 595 600 605 Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln
Glu Pro Pro Glu His 610 615 620 Met Ala Glu Leu Gln Arg Asn Glu Gln
Glu Gln Pro Leu Gly Gln Trp 625 630 635 640 His Leu Ser Lys Arg Asp
Thr Gly Ala Ala Leu Leu Ala Glu Ser Arg 645 650 655 Ala Glu Lys Asn
Arg Leu Trp Gly Pro Leu Glu Val Arg Arg Val Gly 660 665 670 Arg Ser
Ser Lys Gln Leu Val Asp Ile Pro Glu Gly Gln Leu Glu Ala 675 680 685
Arg Ala Gly Arg Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly 690
695 700 Phe Ser Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Leu
Ser 705 710 715 720 Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Gln
Ala Lys Ile Arg 725 730 735 Ala Leu Lys Gly His Ala Gly His Pro Ala
Ala 740 745 332199PRTHomo sapiens 332Met Lys Trp Val Trp Ala Leu
Leu Leu Leu Ala Ala Trp Ala Ala Ala 1 5 10 15 Glu Arg Asp Cys Arg
Val Ser Ser Phe Arg Val Lys Glu Asn Phe Asp 20 25 30 Lys Ala Arg
Phe Ser Gly Thr Trp Tyr Ala Met Ala Lys Lys Asp Pro 35 40 45 Glu
Gly Leu Phe Leu Gln Asp Asn Ile Val Ala Glu Phe Ser Val Asp 50 55
60 Glu Thr Gly Gln Met Ser Ala Thr Ala Lys Gly Arg Val Arg Leu Leu
65 70 75 80 Asn Asn Trp Asp Val Cys Ala Asp Met Val Gly Thr Phe Thr
Asp Thr 85 90 95 Glu Asp Pro Ala Lys Phe Lys Met Lys Tyr Trp Gly
Val Ala Ser Phe 100 105 110 Leu Gln Lys Gly Asn Asp Asp His Trp Ile
Val Asp Thr Asp Tyr Asp 115 120 125 Thr Tyr Ala Val Gln Tyr Ser Cys
Arg Leu Leu Asn Leu Asp Gly Thr 130 135 140 Cys Ala Asp Ser Tyr Ser
Phe Val Phe Ser Arg Asp Pro Asn Gly Leu 145 150 155 160 Pro Pro Glu
Ala Gln Lys Ile Val Arg Gln Arg Gln Glu Glu Leu Cys 165 170 175 Leu
Ala Arg Gln Tyr Arg Leu Ile Val His Asn Gly Tyr Cys Asp Gly 180 185
190 Arg Ser Glu Arg Asn Leu Leu 195 333418PRTHomo sapiens 333Met
Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 1 5 10
15 Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
20 25 30 Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr
Phe Asn 35 40 45 Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser
Leu Tyr Arg Gln 50 55 60 Leu Ala His Gln Ser Asn Ser Thr Asn Ile
Phe Phe Ser Pro Val Ser 65 70 75 80 Ile Ala Thr Ala Phe Ala Met Leu
Ser Leu Gly Thr Lys Ala Asp Thr 85 90 95 His Asp Glu Ile Leu Glu
Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 100 105 110 Glu Ala Gln Ile
His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 115 120 125 Gln Pro
Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 130 135 140
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 145
150 155 160 Leu Tyr His Ser Glu
Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 165 170 175 Ala Lys Lys
Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 180 185 190 Ile
Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 195 200
205 Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val
210 215 220 Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr
Thr Val 225 230 235 240 Lys Val Pro Met Met Lys Arg Leu Gly Met Phe
Asn Ile Gln His Cys 245 250 255 Lys Lys Leu Ser Ser Trp Val Leu Leu
Met Lys Tyr Leu Gly Asn Ala 260 265 270 Thr Ala Ile Phe Phe Leu Pro
Asp Glu Gly Lys Leu Gln His Leu Glu 275 280 285 Asn Glu Leu Thr His
Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 290 295 300 Arg Arg Ser
Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 305 310 315 320
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 325
330 335 Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu
Lys 340 345 350 Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp
Glu Lys Gly 355 360 365 Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala
Ile Pro Met Ser Ile 370 375 380 Pro Pro Glu Val Lys Phe Asn Lys Pro
Phe Val Phe Leu Met Ile Asp 385 390 395 400 Gln Asn Thr Lys Ser Pro
Leu Phe Met Gly Lys Val Val Asn Pro Thr 405 410 415 Gln Lys
334415PRTHomo sapiens 334Met Ser Pro Phe Leu Tyr Leu Val Leu Leu
Val Leu Gly Leu His Ala 1 5 10 15 Thr Ile His Cys Ala Ser Pro Glu
Gly Lys Val Thr Ala Cys His Ser 20 25 30 Ser Gln Pro Asn Ala Thr
Leu Tyr Lys Met Ser Ser Ile Asn Ala Asp 35 40 45 Phe Ala Phe Asn
Leu Tyr Arg Arg Phe Thr Val Glu Thr Pro Asp Lys 50 55 60 Asn Ile
Phe Phe Ser Pro Val Ser Ile Ser Ala Ala Leu Val Met Leu 65 70 75 80
Ser Phe Gly Ala Cys Cys Ser Thr Gln Thr Glu Ile Val Glu Thr Leu 85
90 95 Gly Phe Asn Leu Thr Asp Thr Pro Met Val Glu Ile Gln His Gly
Phe 100 105 110 Gln His Leu Ile Cys Ser Leu Asn Phe Pro Lys Lys Glu
Leu Glu Leu 115 120 125 Gln Ile Gly Asn Ala Leu Phe Ile Gly Lys His
Leu Lys Pro Leu Ala 130 135 140 Lys Phe Leu Asn Asp Val Lys Thr Leu
Tyr Glu Thr Glu Val Phe Ser 145 150 155 160 Thr Asp Phe Ser Asn Ile
Ser Ala Ala Lys Gln Glu Ile Asn Ser His 165 170 175 Val Glu Met Gln
Thr Lys Gly Lys Val Val Gly Leu Ile Gln Asp Leu 180 185 190 Lys Pro
Asn Thr Thr Met Val Leu Val Asn Tyr Ile His Phe Lys Ala 195 200 205
Gln Trp Ala Asn Pro Phe Asp Pro Ser Lys Thr Glu Asp Ser Ser Ser 210
215 220 Phe Leu Ile Asp Lys Thr Thr Thr Val Gln Val Pro Met Met His
Gln 225 230 235 240 Met Glu Gln Tyr Tyr His Leu Val Asp Met Glu Leu
Asn Cys Thr Val 245 250 255 Leu Gln Met Asp Tyr Ser Lys Asn Ala Leu
Ala Leu Phe Val Leu Pro 260 265 270 Lys Glu Gly Gln Met Glu Ser Val
Glu Ala Ala Met Ser Ser Lys Thr 275 280 285 Leu Lys Lys Trp Asn Arg
Leu Leu Gln Lys Gly Trp Val Asp Leu Phe 290 295 300 Val Pro Lys Phe
Ser Ile Ser Ala Thr Tyr Asp Leu Gly Ala Thr Leu 305 310 315 320 Leu
Lys Met Gly Ile Gln His Ala Tyr Ser Glu Asn Ala Asp Phe Ser 325 330
335 Gly Leu Thr Glu Asp Asn Gly Leu Lys Leu Ser Asn Ala Ala His Lys
340 345 350 Ala Val Leu His Ile Gly Glu Lys Gly Thr Glu Ala Ala Ala
Val Pro 355 360 365 Glu Val Glu Leu Ser Asp Gln Pro Glu Asn Thr Phe
Leu His Pro Ile 370 375 380 Ile Gln Ile Asp Arg Ser Phe Met Leu Leu
Ile Leu Glu Arg Ser Thr 385 390 395 400 Arg Ser Ile Leu Phe Leu Gly
Lys Val Val Asn Pro Thr Glu Ala 405 410 415 335464PRTHomo sapiens
335Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val
1 5 10 15 Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val
Thr Cys 20 25 30 His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro
Arg Asp Ile Pro 35 40 45 Met Asn Pro Met Cys Ile Tyr Arg Ser Pro
Glu Lys Lys Ala Thr Glu 50 55 60 Asp Glu Gly Ser Glu Gln Lys Ile
Pro Glu Ala Thr Asn Arg Arg Val 65 70 75 80 Trp Glu Leu Ser Lys Ala
Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln 85 90 95 His Leu Ala Asp
Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro 100 105 110 Leu Ser
Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn 115 120 125
Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser 130
135 140 Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn
Cys 145 150 155 160 Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu
Val Ser Ala Asn 165 170 175 Arg Leu Phe Gly Asp Lys Ser Leu Thr Phe
Asn Glu Thr Tyr Gln Asp 180 185 190 Ile Ser Glu Leu Val Tyr Gly Ala
Lys Leu Gln Pro Leu Asp Phe Lys 195 200 205 Glu Asn Ala Glu Gln Ser
Arg Ala Ala Ile Asn Lys Trp Val Ser Asn 210 215 220 Lys Thr Glu Gly
Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn 225 230 235 240 Glu
Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu 245 250
255 Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr
260 265 270 Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln
Glu Gly 275 280 285 Lys Phe Arg Tyr Arg Arg Val Ala Glu Gly Thr Gln
Val Leu Glu Leu 290 295 300 Pro Phe Lys Gly Asp Asp Ile Thr Met Val
Leu Ile Leu Pro Lys Pro 305 310 315 320 Glu Lys Ser Leu Ala Lys Val
Glu Lys Glu Leu Thr Pro Glu Val Leu 325 330 335 Gln Glu Trp Leu Asp
Glu Leu Glu Glu Met Met Leu Val Val His Met 340 345 350 Pro Arg Phe
Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln Leu Gln 355 360 365 Asp
Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro 370 375
380 Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe
385 390 395 400 His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu
Ala Ala Ala 405 410 415 Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu
Asn Pro Asn Arg Val 420 425 430 Thr Phe Lys Ala Asn Arg Pro Phe Leu
Val Phe Ile Arg Glu Val Pro 435 440 445 Leu Asn Thr Ile Ile Phe Met
Gly Arg Val Ala Asn Pro Cys Val Lys 450 455 460 336418PRTHomo
sapiens 336Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu
Gly His 1 5 10 15 Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu
Gly Ser Pro Asp 20 25 30 Pro Asp Ser Thr Gly Ala Leu Val Glu Glu
Glu Asp Pro Phe Phe Lys 35 40 45 Val Pro Val Asn Lys Leu Ala Ala
Ala Val Ser Asn Phe Gly Tyr Asp 50 55 60 Leu Tyr Arg Val Arg Ser
Ser Thr Ser Pro Thr Thr Asn Val Leu Leu 65 70 75 80 Ser Pro Leu Ser
Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala 85 90 95 Glu Gln
Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu 100 105 110
Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr 115
120 125 Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val
Phe 130 135 140 Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro
Leu Glu Lys 145 150 155 160 Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr
Gly Asn Pro Arg Leu Asp 165 170 175 Leu Gln Glu Ile Asn Asn Trp Val
Gln Ala Gln Met Lys Gly Lys Leu 180 185 190 Ala Arg Ser Thr Lys Glu
Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu 195 200 205 Gly Val Ala His
Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg 210 215 220 Lys Thr
Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg 225 230 235
240 Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp
245 250 255 Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly
Ser Met 260 265 270 Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln
Asn Leu Thr Leu 275 280 285 Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile
His Asp Ile Asp Arg Glu 290 295 300 Leu Lys Thr Val Gln Ala Val Leu
Thr Val Pro Lys Leu Lys Leu Ser 305 310 315 320 Tyr Glu Gly Glu Val
Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser 325 330 335 Leu Phe Asp
Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys 340 345 350 Leu
Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly 355 360
365 Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe
370 375 380 Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu
Arg Asp 385 390 395 400 Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys
Ile Leu Asp Pro Arg 405 410 415 Gly Pro 337223PRTHomo sapiens
337Met Asn Lys Pro Leu Leu Trp Ile Ser Val Leu Thr Ser Leu Leu Glu
1 5 10 15 Ala Phe Ala His Thr Asp Leu Ser Gly Lys Val Phe Val Phe
Pro Arg 20 25 30 Glu Ser Val Thr Asp His Val Asn Leu Ile Thr Pro
Leu Glu Lys Pro 35 40 45 Leu Gln Asn Phe Thr Leu Cys Phe Arg Ala
Tyr Ser Asp Leu Ser Arg 50 55 60 Ala Tyr Ser Leu Phe Ser Tyr Asn
Thr Gln Gly Arg Asp Asn Glu Leu 65 70 75 80 Leu Val Tyr Lys Glu Arg
Val Gly Glu Tyr Ser Leu Tyr Ile Gly Arg 85 90 95 His Lys Val Thr
Ser Lys Val Ile Glu Lys Phe Pro Ala Pro Val His 100 105 110 Ile Cys
Val Ser Trp Glu Ser Ser Ser Gly Ile Ala Glu Phe Trp Ile 115 120 125
Asn Gly Thr Pro Leu Val Lys Lys Gly Leu Arg Gln Gly Tyr Phe Val 130
135 140 Glu Ala Gln Pro Lys Ile Val Leu Gly Gln Glu Gln Asp Ser Tyr
Gly 145 150 155 160 Gly Lys Phe Asp Arg Ser Gln Ser Phe Val Gly Glu
Ile Gly Asp Leu 165 170 175 Tyr Met Trp Asp Ser Val Leu Pro Pro Glu
Asn Ile Leu Ser Ala Tyr 180 185 190 Gln Gly Thr Pro Leu Pro Ala Asn
Ile Leu Asp Trp Gln Ala Leu Asn 195 200 205 Tyr Glu Ile Arg Gly Tyr
Val Ile Ile Lys Pro Leu Val Trp Val 210 215 220 338402PRTHomo
sapiens 338Met Glu Ser Arg Gly Pro Leu Ala Thr Ser Arg Leu Leu Leu
Leu Leu 1 5 10 15 Leu Leu Leu Leu Leu Arg His Thr Arg Gln Gly Trp
Ala Leu Arg Pro 20 25 30 Val Leu Pro Thr Gln Ser Ala His Asp Pro
Pro Ala Val His Leu Ser 35 40 45 Asn Gly Pro Gly Gln Glu Pro Ile
Ala Val Met Thr Phe Asp Leu Thr 50 55 60 Lys Ile Thr Lys Thr Ser
Ser Ser Phe Glu Val Arg Thr Trp Asp Pro 65 70 75 80 Glu Gly Val Ile
Phe Tyr Gly Asp Thr Asn Pro Lys Asp Asp Trp Phe 85 90 95 Met Leu
Gly Leu Arg Asp Gly Arg Pro Glu Ile Gln Leu His Asn His 100 105 110
Trp Ala Gln Leu Thr Val Gly Ala Gly Pro Arg Leu Asp Asp Gly Arg 115
120 125 Trp His Gln Val Glu Val Lys Met Glu Gly Asp Ser Val Leu Leu
Glu 130 135 140 Val Asp Gly Glu Glu Val Leu Arg Leu Arg Gln Val Ser
Gly Pro Leu 145 150 155 160 Thr Ser Lys Arg His Pro Ile Met Arg Ile
Ala Leu Gly Gly Leu Leu 165 170 175 Phe Pro Ala Ser Asn Leu Arg Leu
Pro Leu Val Pro Ala Leu Asp Gly 180 185 190 Cys Leu Arg Arg Asp Ser
Trp Leu Asp Lys Gln Ala Glu Ile Ser Ala 195 200 205 Ser Ala Pro Thr
Ser Leu Arg Ser Cys Asp Val Glu Ser Asn Pro Gly 210 215 220 Ile Phe
Leu Pro Pro Gly Thr Gln Ala Glu Phe Asn Leu Arg Asp Ile 225 230 235
240 Pro Gln Pro His Ala Glu Pro Trp Ala Phe Ser Leu Asp Leu Gly Leu
245 250 255 Lys Gln Ala Ala Gly Ser Gly His Leu Leu Ala Leu Gly Thr
Pro Glu 260 265 270 Asn Pro Ser Trp Leu Ser Leu His Leu Gln Asp Gln
Lys Val Val Leu 275 280 285 Ser Ser Gly Ser Gly Pro Gly Leu Asp Leu
Pro Leu Val Leu Gly Leu 290 295 300 Pro Leu Gln Leu Lys Leu Ser Met
Ser Arg Val Val Leu Ser Gln Gly 305 310 315 320 Ser Lys Met Lys Ala
Leu Ala Leu Pro Pro Leu Gly Leu Ala Pro Leu 325 330 335 Leu Asn Leu
Trp Ala Lys Pro Gln Gly Arg Leu Phe Leu Gly Ala Leu 340 345 350 Pro
Gly Glu Asp Ser Ser Thr Ser Phe Cys Leu Asn Gly Leu Trp Ala 355 360
365 Gln Gly Gln Arg Leu Asp Val Asp Gln Ala Leu Asn Arg Ser His Glu
370 375 380 Ile Trp Thr His Ser Cys Pro Gln Ser Pro Gly Asn Gly Thr
Asp Ala 385 390 395 400 Ser His 339248PRTHomo sapiens 339Met Ser
Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 1 5 10 15
Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 20
25 30 Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro
Gly 35 40 45 Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu
Pro Gly Gln 50 55 60 Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys
Leu Gly Pro Pro Gly 65 70 75 80 Asn Pro Gly Pro Ser Gly Ser Pro Gly
Pro Lys Gly Gln Lys Gly Asp 85 90 95 Pro Gly Lys Ser Pro Asp Gly
Asp Ser Ser Leu Ala Ala Ser Glu Arg 100 105 110 Lys Ala
Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 115 120 125
Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 130
135 140 Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln
Ala 145 150 155 160 Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly
Ala Ile Gln Asn 165 170 175 Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile
Thr Asp Glu Lys Thr Glu 180 185 190 Gly Gln Phe Val Asp Leu Thr Gly
Asn Arg Leu Thr Tyr Thr Asn Trp 195 200 205 Asn Glu Gly Glu Pro Asn
Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 210 215 220 Leu Leu Lys Asn
Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 225 230 235 240 Leu
Ala Val Cys Glu Phe Pro Ile 245 3402349PRTHomo sapiens 340Met Ala
Ala Val Leu Gln Gln Val Leu Glu Arg Thr Glu Leu Asn Lys 1 5 10 15
Leu Pro Lys Ser Val Gln Asn Lys Leu Glu Lys Phe Leu Ala Asp Gln 20
25 30 Gln Ser Glu Ile Asp Gly Leu Lys Gly Arg His Glu Lys Phe Lys
Val 35 40 45 Glu Ser Glu Gln Gln Tyr Phe Glu Ile Glu Lys Arg Leu
Ser His Ser 50 55 60 Gln Glu Arg Leu Val Asn Glu Thr Arg Glu Cys
Gln Ser Leu Arg Leu 65 70 75 80 Glu Leu Glu Lys Leu Asn Asn Gln Leu
Lys Ala Leu Thr Glu Lys Asn 85 90 95 Lys Glu Leu Glu Ile Ala Gln
Asp Arg Asn Ile Ala Ile Gln Ser Gln 100 105 110 Phe Thr Arg Thr Lys
Glu Glu Leu Glu Ala Glu Lys Arg Asp Leu Ile 115 120 125 Arg Thr Asn
Glu Arg Leu Ser Gln Glu Leu Glu Tyr Leu Thr Glu Asp 130 135 140 Val
Lys Arg Leu Asn Glu Lys Leu Lys Glu Ser Asn Thr Thr Lys Gly 145 150
155 160 Glu Leu Gln Leu Lys Leu Asp Glu Leu Gln Ala Ser Asp Val Ser
Val 165 170 175 Lys Tyr Arg Glu Lys Arg Leu Glu Gln Glu Lys Glu Leu
Leu His Ser 180 185 190 Gln Asn Thr Trp Leu Asn Thr Glu Leu Lys Thr
Lys Thr Asp Glu Leu 195 200 205 Leu Ala Leu Gly Arg Glu Lys Gly Asn
Glu Ile Leu Glu Leu Lys Cys 210 215 220 Asn Leu Glu Asn Lys Lys Glu
Glu Val Ser Arg Leu Glu Glu Gln Met 225 230 235 240 Asn Gly Leu Lys
Thr Ser Asn Glu His Leu Gln Lys His Val Glu Asp 245 250 255 Leu Leu
Thr Lys Leu Lys Glu Ala Lys Glu Gln Gln Ala Ser Met Glu 260 265 270
Glu Lys Phe His Asn Glu Leu Asn Ala His Ile Lys Leu Ser Asn Leu 275
280 285 Tyr Lys Ser Ala Ala Asp Asp Ser Glu Ala Lys Ser Asn Glu Leu
Thr 290 295 300 Arg Ala Val Glu Glu Leu His Lys Leu Leu Lys Glu Ala
Gly Glu Ala 305 310 315 320 Asn Lys Ala Ile Gln Asp His Leu Leu Glu
Val Glu Gln Ser Lys Asp 325 330 335 Gln Met Glu Lys Glu Met Leu Glu
Lys Ile Gly Arg Leu Glu Lys Glu 340 345 350 Leu Glu Asn Ala Asn Asp
Leu Leu Ser Ala Thr Lys Arg Lys Gly Ala 355 360 365 Ile Leu Ser Glu
Glu Glu Leu Ala Ala Met Ser Pro Thr Ala Ala Ala 370 375 380 Val Ala
Lys Ile Val Lys Pro Gly Met Lys Leu Thr Glu Leu Tyr Asn 385 390 395
400 Ala Tyr Val Glu Thr Gln Asp Gln Leu Leu Leu Glu Lys Leu Glu Asn
405 410 415 Lys Arg Ile Asn Lys Tyr Leu Asp Glu Ile Val Lys Glu Val
Glu Ala 420 425 430 Lys Ala Pro Ile Leu Lys Arg Gln Arg Glu Glu Tyr
Glu Arg Ala Gln 435 440 445 Lys Ala Val Ala Ser Leu Ser Val Lys Leu
Glu Gln Ala Met Lys Glu 450 455 460 Ile Gln Arg Leu Gln Glu Asp Thr
Asp Lys Ala Asn Lys Gln Ser Ser 465 470 475 480 Val Leu Glu Arg Asp
Asn Arg Arg Met Glu Ile Gln Val Lys Asp Leu 485 490 495 Ser Gln Gln
Ile Arg Val Leu Leu Met Glu Leu Glu Glu Ala Arg Gly 500 505 510 Asn
His Val Ile Arg Asp Glu Glu Val Ser Ser Ala Asp Ile Ser Ser 515 520
525 Ser Ser Glu Val Ile Ser Gln His Leu Val Ser Tyr Arg Asn Ile Glu
530 535 540 Glu Leu Gln Gln Gln Asn Gln Arg Leu Leu Val Ala Leu Arg
Glu Leu 545 550 555 560 Gly Glu Thr Arg Glu Arg Glu Glu Gln Glu Thr
Thr Ser Ser Lys Ile 565 570 575 Thr Glu Leu Gln Leu Lys Leu Glu Ser
Ala Leu Thr Glu Leu Glu Gln 580 585 590 Leu Arg Lys Ser Arg Gln His
Gln Met Gln Leu Val Asp Ser Ile Val 595 600 605 Arg Gln Arg Asp Met
Tyr Arg Ile Leu Leu Ser Gln Thr Thr Gly Val 610 615 620 Ala Ile Pro
Leu His Ala Ser Ser Leu Asp Asp Val Ser Leu Ala Ser 625 630 635 640
Thr Pro Lys Arg Pro Ser Thr Ser Gln Thr Val Ser Thr Pro Ala Pro 645
650 655 Val Pro Val Ile Glu Ser Thr Glu Ala Ile Glu Ala Lys Ala Ala
Leu 660 665 670 Lys Gln Leu Gln Glu Ile Phe Glu Asn Tyr Lys Lys Glu
Lys Ala Glu 675 680 685 Asn Glu Lys Ile Gln Asn Glu Gln Leu Glu Lys
Leu Gln Glu Gln Val 690 695 700 Thr Asp Leu Arg Ser Gln Asn Thr Lys
Ile Ser Thr Gln Leu Asp Phe 705 710 715 720 Ala Ser Lys Arg Tyr Glu
Met Leu Gln Asp Asn Val Glu Gly Tyr Arg 725 730 735 Arg Glu Ile Thr
Ser Leu His Glu Arg Asn Gln Lys Leu Thr Ala Thr 740 745 750 Thr Gln
Lys Gln Glu Gln Ile Ile Asn Thr Met Thr Gln Asp Leu Arg 755 760 765
Gly Ala Asn Glu Lys Leu Ala Val Ala Glu Val Arg Ala Glu Asn Leu 770
775 780 Lys Lys Glu Lys Glu Met Leu Lys Leu Ser Glu Val Arg Leu Ser
Gln 785 790 795 800 Gln Arg Glu Ser Leu Leu Ala Glu Gln Arg Gly Gln
Asn Leu Leu Leu 805 810 815 Thr Asn Leu Gln Thr Ile Gln Gly Ile Leu
Glu Arg Ser Glu Thr Glu 820 825 830 Thr Lys Gln Arg Leu Ser Ser Gln
Ile Glu Lys Leu Glu His Glu Ile 835 840 845 Ser His Leu Lys Lys Lys
Leu Glu Asn Glu Val Glu Gln Arg His Thr 850 855 860 Leu Thr Arg Asn
Leu Asp Val Gln Leu Leu Asp Thr Lys Arg Gln Leu 865 870 875 880 Asp
Thr Glu Thr Asn Leu His Leu Asn Thr Lys Glu Leu Leu Lys Asn 885 890
895 Ala Gln Lys Glu Ile Ala Thr Leu Lys Gln His Leu Ser Asn Met Glu
900 905 910 Val Gln Val Ala Ser Gln Ser Ser Gln Arg Thr Gly Lys Gly
Gln Pro 915 920 925 Ser Asn Lys Glu Asp Val Asp Asp Leu Val Ser Gln
Leu Arg Gln Thr 930 935 940 Glu Glu Gln Val Asn Asp Leu Lys Glu Arg
Leu Lys Thr Ser Thr Ser 945 950 955 960 Asn Val Glu Gln Tyr Gln Ala
Met Val Thr Ser Leu Glu Glu Ser Leu 965 970 975 Asn Lys Glu Lys Gln
Val Thr Glu Glu Val Arg Lys Asn Ile Glu Val 980 985 990 Arg Leu Lys
Glu Ser Ala Glu Phe Gln Thr Gln Leu Glu Lys Lys Leu 995 1000 1005
Met Glu Val Glu Lys Glu Lys Gln Glu Leu Gln Asp Asp Lys Arg 1010
1015 1020 Arg Ala Ile Glu Ser Met Glu Gln Gln Leu Ser Glu Leu Lys
Lys 1025 1030 1035 Thr Leu Ser Ser Val Gln Asn Glu Val Gln Glu Ala
Leu Gln Arg 1040 1045 1050 Ala Ser Thr Ala Leu Ser Asn Glu Gln Gln
Ala Arg Arg Asp Cys 1055 1060 1065 Gln Glu Gln Ala Lys Ile Ala Val
Glu Ala Gln Asn Lys Tyr Glu 1070 1075 1080 Arg Glu Leu Met Leu His
Ala Ala Asp Val Glu Ala Leu Gln Ala 1085 1090 1095 Ala Lys Glu Gln
Val Ser Lys Met Ala Ser Val Arg Gln His Leu 1100 1105 1110 Glu Glu
Thr Thr Gln Lys Ala Glu Ser Gln Leu Leu Glu Cys Lys 1115 1120 1125
Ala Ser Trp Glu Glu Arg Glu Arg Met Leu Lys Asp Glu Val Ser 1130
1135 1140 Lys Cys Val Cys Arg Cys Glu Asp Leu Glu Lys Gln Asn Arg
Leu 1145 1150 1155 Leu His Asp Gln Ile Glu Lys Leu Ser Asp Lys Val
Val Ala Ser 1160 1165 1170 Val Lys Glu Gly Val Gln Gly Pro Leu Asn
Val Ser Leu Ser Glu 1175 1180 1185 Glu Gly Lys Ser Gln Glu Gln Ile
Leu Glu Ile Leu Arg Phe Ile 1190 1195 1200 Arg Arg Glu Lys Glu Ile
Ala Glu Thr Arg Phe Glu Val Ala Gln 1205 1210 1215 Val Glu Ser Leu
Arg Tyr Arg Gln Arg Val Glu Leu Leu Glu Arg 1220 1225 1230 Glu Leu
Gln Glu Leu Glu Asp Ser Leu Asn Ala Glu Arg Glu Lys 1235 1240 1245
Val Gln Val Thr Ala Lys Thr Met Ala Gln His Glu Glu Leu Met 1250
1255 1260 Lys Lys Thr Glu Thr Met Asn Val Val Met Glu Thr Asn Lys
Met 1265 1270 1275 Leu Arg Glu Glu Lys Glu Arg Leu Glu Gln Asp Leu
Gln Gln Met 1280 1285 1290 Gln Ala Lys Val Arg Lys Leu Glu Leu Asp
Ile Leu Pro Leu Gln 1295 1300 1305 Glu Ala Asn Ala Glu Leu Ser Glu
Lys Ser Gly Met Leu Gln Ala 1310 1315 1320 Glu Lys Lys Leu Leu Glu
Glu Asp Val Lys Arg Trp Lys Ala Arg 1325 1330 1335 Asn Gln His Leu
Val Ser Gln Gln Lys Asp Pro Asp Thr Glu Glu 1340 1345 1350 Tyr Arg
Lys Leu Leu Ser Glu Lys Glu Val His Thr Lys Arg Ile 1355 1360 1365
Gln Gln Leu Thr Glu Glu Ile Gly Arg Leu Lys Ala Glu Ile Ala 1370
1375 1380 Arg Ser Asn Ala Ser Leu Thr Asn Asn Gln Asn Leu Ile Gln
Ser 1385 1390 1395 Leu Lys Glu Asp Leu Asn Lys Val Arg Thr Glu Lys
Glu Thr Ile 1400 1405 1410 Gln Lys Asp Leu Asp Ala Lys Ile Ile Asp
Ile Gln Glu Lys Val 1415 1420 1425 Lys Thr Ile Thr Gln Val Lys Lys
Ile Gly Arg Arg Tyr Lys Thr 1430 1435 1440 Gln Tyr Glu Glu Leu Lys
Ala Gln Gln Asp Lys Val Met Glu Thr 1445 1450 1455 Ser Ala Gln Ser
Ser Gly Asp His Gln Glu Gln His Val Ser Val 1460 1465 1470 Gln Glu
Met Gln Glu Leu Lys Glu Thr Leu Asn Gln Ala Glu Thr 1475 1480 1485
Lys Ser Lys Ser Leu Glu Ser Gln Val Glu Asn Leu Gln Lys Thr 1490
1495 1500 Leu Ser Glu Lys Glu Thr Glu Ala Arg Asn Leu Gln Glu Gln
Thr 1505 1510 1515 Val Gln Leu Gln Ser Glu Leu Ser Arg Leu Arg Gln
Asp Leu Gln 1520 1525 1530 Asp Arg Thr Thr Gln Glu Glu Gln Leu Arg
Gln Gln Ile Thr Glu 1535 1540 1545 Lys Glu Glu Lys Thr Arg Lys Ala
Ile Val Ala Ala Lys Ser Lys 1550 1555 1560 Ile Ala His Leu Ala Gly
Val Lys Asp Gln Leu Thr Lys Glu Asn 1565 1570 1575 Glu Glu Leu Lys
Gln Arg Asn Gly Ala Leu Asp Gln Gln Lys Asp 1580 1585 1590 Glu Leu
Asp Val Arg Ile Thr Ala Leu Lys Ser Gln Tyr Glu Gly 1595 1600 1605
Arg Ile Ser Arg Leu Glu Arg Glu Leu Arg Glu His Gln Glu Arg 1610
1615 1620 His Leu Glu Gln Arg Asp Glu Pro Gln Glu Pro Ser Asn Lys
Val 1625 1630 1635 Pro Glu Gln Gln Arg Gln Ile Thr Leu Lys Thr Thr
Pro Ala Ser 1640 1645 1650 Gly Glu Arg Gly Ile Ala Ser Thr Ser Asp
Pro Pro Thr Ala Asn 1655 1660 1665 Ile Lys Pro Thr Pro Val Val Ser
Thr Pro Ser Lys Val Thr Ala 1670 1675 1680 Ala Ala Met Ala Gly Asn
Lys Ser Thr Pro Arg Ala Ser Ile Arg 1685 1690 1695 Pro Met Val Thr
Pro Ala Thr Val Thr Asn Pro Thr Thr Thr Pro 1700 1705 1710 Thr Ala
Thr Val Met Pro Thr Thr Gln Val Glu Ser Gln Glu Ala 1715 1720 1725
Met Gln Ser Glu Gly Pro Val Glu His Val Pro Val Phe Gly Ser 1730
1735 1740 Thr Ser Gly Ser Val Arg Ser Thr Ser Pro Asn Val Gln Pro
Ser 1745 1750 1755 Ile Ser Gln Pro Ile Leu Thr Val Gln Gln Gln Thr
Gln Ala Thr 1760 1765 1770 Ala Phe Val Gln Pro Thr Gln Gln Ser His
Pro Gln Ile Glu Pro 1775 1780 1785 Ala Asn Gln Glu Leu Ser Ser Asn
Ile Val Glu Val Val Gln Ser 1790 1795 1800 Ser Pro Val Glu Arg Pro
Ser Thr Ser Thr Ala Val Phe Gly Thr 1805 1810 1815 Val Ser Ala Thr
Pro Ser Ser Ser Leu Pro Lys Arg Thr Arg Glu 1820 1825 1830 Glu Glu
Glu Asp Ser Thr Ile Glu Ala Ser Asp Gln Val Ser Asp 1835 1840 1845
Asp Thr Val Glu Met Pro Leu Pro Lys Lys Leu Lys Ser Val Thr 1850
1855 1860 Pro Val Gly Thr Glu Glu Glu Val Met Ala Glu Glu Ser Thr
Asp 1865 1870 1875 Gly Glu Val Glu Thr Gln Val Tyr Asn Gln Asp Ser
Gln Asp Ser 1880 1885 1890 Ile Gly Glu Gly Val Thr Gln Gly Asp Tyr
Thr Pro Met Glu Asp 1895 1900 1905 Ser Glu Glu Thr Ser Gln Ser Leu
Gln Ile Asp Leu Gly Pro Leu 1910 1915 1920 Gln Ser Asp Gln Gln Thr
Thr Thr Ser Ser Gln Asp Gly Gln Gly 1925 1930 1935 Lys Gly Asp Asp
Val Ile Val Ile Asp Ser Asp Asp Glu Glu Glu 1940 1945 1950 Asp Glu
Glu Asp Asp Asp Asp Asp Glu Asp Asp Thr Gly Met Gly 1955 1960 1965
Asp Glu Gly Glu Asp Ser Asn Glu Gly Thr Gly Ser Ala Asp Gly 1970
1975 1980 Asn Asp Gly Tyr Glu Ala Asp Asp Ala Glu Gly Gly Asp Gly
Thr 1985 1990 1995 Asp Pro Gly Thr Glu Thr Glu Glu Ser Met Gly Gly
Gly Glu Gly 2000 2005 2010 Asn His Arg Ala Ala Asp Ser Gln Asn Ser
Gly Glu Gly Asn Thr 2015 2020 2025 Gly Ala Ala Glu Ser Ser Phe Ser
Gln Glu Val Ser Arg Glu Gln 2030 2035 2040 Gln Pro Ser Ser Ala Ser
Glu Arg Gln Ala Pro Arg Ala Pro Gln 2045 2050 2055 Ser Pro Arg Arg
Pro Pro His Pro Leu Pro Pro Arg Leu Thr Ile 2060 2065 2070 His Ala
Pro Pro Gln Glu Leu Gly Pro Pro Val Gln Arg Ile Gln 2075 2080 2085
Met Thr Arg Arg Gln Ser Val Gly Arg Gly Leu Gln Leu Thr Pro 2090
2095 2100 Gly Ile Gly Gly Met Gln Gln His Phe Phe Asp Asp Glu Asp
Arg 2105
2110 2115 Thr Val Pro Ser Thr Pro Thr Leu Val Val Pro His Arg Thr
Asp 2120 2125 2130 Gly Phe Ala Glu Ala Ile His Ser Pro Gln Val Ala
Gly Val Pro 2135 2140 2145 Arg Phe Arg Phe Gly Pro Pro Glu Asp Met
Pro Gln Thr Ser Ser 2150 2155 2160 Ser His Ser Asp Leu Gly Gln Leu
Ala Ser Gln Gly Gly Leu Gly 2165 2170 2175 Met Tyr Glu Thr Pro Leu
Phe Leu Ala His Glu Glu Glu Ser Gly 2180 2185 2190 Gly Arg Ser Val
Pro Thr Thr Pro Leu Gln Val Ala Ala Pro Val 2195 2200 2205 Thr Val
Phe Thr Glu Ser Thr Thr Ser Asp Ala Ser Glu His Ala 2210 2215 2220
Ser Gln Ser Val Pro Met Val Thr Thr Ser Thr Gly Thr Leu Ser 2225
2230 2235 Thr Thr Asn Glu Thr Ala Thr Gly Asp Asp Gly Asp Glu Val
Phe 2240 2245 2250 Val Glu Ala Glu Ser Glu Gly Ile Ser Ser Glu Ala
Gly Leu Glu 2255 2260 2265 Ile Asp Ser Gln Gln Glu Glu Glu Pro Val
Gln Ala Ser Asp Glu 2270 2275 2280 Ser Asp Leu Pro Ser Thr Ser Gln
Asp Pro Pro Ser Ser Ser Ser 2285 2290 2295 Val Asp Thr Ser Ser Ser
Gln Pro Lys Pro Phe Arg Arg Val Arg 2300 2305 2310 Leu Gln Thr Thr
Leu Arg Gln Gly Val Arg Gly Arg Gln Phe Asn 2315 2320 2325 Arg Gln
Arg Gly Val Ser His Ala Met Gly Gly Arg Gly Gly Ile 2330 2335 2340
Asn Arg Gly Asn Ile Asn 2345 3411090PRTHomo sapiens 341Met Ala Thr
Leu Leu Ser His Pro Gln Gln Arg Pro Pro Phe Leu Arg 1 5 10 15 Gln
Ala Ile Lys Ile Arg Arg Arg Arg Val Arg Asp Leu Gln Asp Pro 20 25
30 Pro Pro Gln Met Ala Pro Glu Ile Gln Pro Pro Ser His His Phe Ser
35 40 45 Pro Glu Gln Arg Ala Leu Leu Tyr Glu Asp Ala Leu Tyr Thr
Val Leu 50 55 60 His Arg Leu Gly His Pro Glu Pro Asn His Val Thr
Glu Ala Ser Glu 65 70 75 80 Leu Leu Arg Tyr Leu Gln Glu Ala Phe His
Val Glu Pro Glu Glu His 85 90 95 Gln Gln Thr Leu Gln Arg Val Arg
Glu Leu Glu Lys Pro Ile Phe Cys 100 105 110 Leu Lys Ala Thr Val Lys
Gln Ala Lys Gly Ile Leu Gly Lys Asp Val 115 120 125 Ser Gly Phe Ser
Asp Pro Tyr Cys Leu Leu Gly Ile Glu Gln Gly Val 130 135 140 Gly Val
Pro Gly Gly Ser Pro Gly Ser Arg His Arg Gln Lys Ala Val 145 150 155
160 Val Arg His Thr Ile Pro Glu Glu Glu Thr His Arg Thr Gln Val Ile
165 170 175 Thr Gln Thr Leu Asn Pro Val Trp Asp Glu Thr Phe Ile Leu
Glu Phe 180 185 190 Glu Asp Ile Thr Asn Ala Ser Phe His Leu Asp Met
Trp Asp Leu Asp 195 200 205 Thr Val Glu Ser Val Arg Gln Lys Leu Gly
Glu Leu Thr Asp Leu His 210 215 220 Gly Leu Arg Arg Ile Phe Lys Glu
Ala Arg Lys Asp Lys Gly Gln Asp 225 230 235 240 Asp Phe Leu Gly Asn
Val Val Leu Arg Leu Gln Asp Leu Arg Cys Arg 245 250 255 Glu Asp Gln
Trp Tyr Pro Leu Glu Pro Arg Thr Glu Thr Tyr Pro Asp 260 265 270 Arg
Gly Gln Cys His Leu Gln Phe Gln Leu Ile His Lys Arg Arg Ala 275 280
285 Thr Ser Ala Ser Arg Ser Gln Pro Ser Tyr Thr Val His Leu His Leu
290 295 300 Leu Gln Gln Leu Val Ser His Glu Val Thr Gln His Glu Ala
Gly Ser 305 310 315 320 Thr Ser Trp Asp Gly Ser Leu Ser Pro Gln Ala
Ala Thr Val Leu Phe 325 330 335 Leu His Ala Thr Gln Lys Asp Leu Ser
Asp Phe His Gln Ser Met Ala 340 345 350 Gln Trp Leu Ala Tyr Ser Arg
Leu Tyr Gln Ser Leu Glu Phe Pro Ser 355 360 365 Ser Cys Leu Leu His
Pro Ile Thr Ser Ile Glu Tyr Gln Trp Ile Gln 370 375 380 Gly Arg Leu
Lys Ala Glu Gln Gln Glu Glu Leu Ala Ala Ser Phe Ser 385 390 395 400
Ser Leu Leu Thr Tyr Gly Leu Ser Leu Ile Arg Arg Phe Arg Ser Val 405
410 415 Phe Pro Leu Ser Val Ser Asp Ser Pro Ala Arg Leu Gln Ser Leu
Leu 420 425 430 Arg Val Leu Val Gln Met Cys Lys Met Lys Ala Phe Gly
Glu Leu Cys 435 440 445 Pro Asn Thr Ala Pro Leu Pro Gln Leu Val Thr
Glu Ala Leu Gln Thr 450 455 460 Gly Thr Thr Glu Trp Phe His Leu Lys
Gln Gln His His Gln Pro Met 465 470 475 480 Val Gln Gly Ile Pro Glu
Ala Gly Lys Ala Leu Leu Gly Leu Val Gln 485 490 495 Asp Val Ile Gly
Asp Leu His Gln Cys Gln Arg Thr Trp Asp Lys Ile 500 505 510 Phe His
Asn Thr Leu Lys Ile His Leu Phe Ser Met Ala Phe Arg Glu 515 520 525
Leu Gln Trp Leu Val Ala Lys Arg Val Gln Asp His Thr Thr Val Val 530
535 540 Gly Asp Val Val Ser Pro Glu Met Gly Glu Ser Leu Phe Gln Leu
Tyr 545 550 555 560 Ile Ser Leu Lys Glu Leu Cys Gln Leu Arg Met Ser
Ser Ser Glu Arg 565 570 575 Asp Gly Val Leu Ala Leu Asp Asn Phe His
Arg Trp Phe Gln Pro Ala 580 585 590 Ile Pro Ser Trp Leu Gln Lys Thr
Tyr Asn Glu Ala Leu Ala Arg Val 595 600 605 Gln Arg Ala Val Gln Met
Asp Glu Leu Val Pro Leu Gly Glu Leu Thr 610 615 620 Lys His Ser Thr
Ser Ala Val Asp Leu Ser Thr Cys Phe Ala Gln Ile 625 630 635 640 Ser
His Thr Ala Arg Gln Leu Asp Trp Pro Asp Pro Glu Glu Ala Phe 645 650
655 Met Ile Thr Val Lys Phe Val Glu Asp Thr Cys Arg Leu Ala Leu Val
660 665 670 Tyr Cys Ser Leu Ile Lys Ala Arg Ala Arg Glu Leu Ser Ser
Gly Gln 675 680 685 Lys Asp Gln Gly Gln Ala Ala Asn Met Leu Cys Val
Val Val Asn Asp 690 695 700 Met Glu Gln Leu Arg Leu Val Ile Gly Lys
Leu Pro Ala Gln Leu Ala 705 710 715 720 Trp Glu Ala Leu Glu Gln Arg
Val Gly Ala Val Leu Glu Gln Gly Gln 725 730 735 Leu Gln Asn Thr Leu
His Ala Gln Leu Gln Ser Ala Leu Ala Gly Leu 740 745 750 Gly His Glu
Ile Arg Thr Gly Val Arg Thr Leu Ala Glu Gln Leu Glu 755 760 765 Val
Gly Ile Ala Lys His Ile Gln Lys Leu Val Gly Val Arg Glu Ser 770 775
780 Val Leu Pro Glu Asp Ala Ile Leu Pro Leu Met Lys Phe Leu Glu Val
785 790 795 800 Glu Leu Cys Tyr Met Asn Thr Asn Leu Val Gln Glu Asn
Phe Ser Ser 805 810 815 Leu Leu Thr Leu Leu Trp Thr His Thr Leu Thr
Val Leu Val Glu Ala 820 825 830 Ala Ala Ser Gln Arg Ser Ser Ser Leu
Ala Ser Asn Arg Leu Lys Ile 835 840 845 Ala Leu Gln Asn Leu Glu Ile
Cys Phe His Ala Glu Gly Cys Gly Leu 850 855 860 Pro Pro Lys Ala Leu
His Thr Ala Thr Phe Gln Ala Leu Gln Arg Asp 865 870 875 880 Leu Glu
Leu Gln Ala Ala Ser Ser Arg Glu Leu Ile Arg Lys Tyr Phe 885 890 895
Cys Ser Arg Ile Gln Gln Gln Ala Glu Thr Thr Ser Glu Glu Leu Gly 900
905 910 Ala Val Thr Val Lys Ala Ser Tyr Arg Ala Ser Glu Gln Lys Leu
Arg 915 920 925 Val Glu Leu Leu Ser Ala Ser Ser Leu Leu Pro Leu Asp
Ser Asn Gly 930 935 940 Ser Ser Asp Pro Phe Val Gln Leu Thr Leu Glu
Pro Arg His Glu Phe 945 950 955 960 Pro Glu Leu Ala Ala Arg Glu Thr
Gln Lys His Lys Lys Asp Leu His 965 970 975 Pro Leu Phe Asp Glu Thr
Phe Glu Phe Leu Val Pro Ala Glu Pro Cys 980 985 990 Arg Lys Ala Gly
Ala Cys Leu Leu Leu Thr Val Leu Asp Tyr Asp Thr 995 1000 1005 Leu
Gly Ala Asp Asp Leu Glu Gly Glu Ala Phe Leu Pro Leu Arg 1010 1015
1020 Glu Val Pro Gly Leu Ser Gly Ser Glu Glu Pro Gly Glu Val Pro
1025 1030 1035 Gln Thr Arg Leu Pro Leu Thr Tyr Pro Ala Pro Asn Gly
Asp Pro 1040 1045 1050 Ile Leu Gln Leu Leu Glu Gly Arg Lys Gly Asp
Arg Glu Ala Gln 1055 1060 1065 Val Phe Val Arg Leu Arg Arg His Arg
Ala Lys Gln Ala Ser Gln 1070 1075 1080 His Ala Leu Arg Pro Ala Pro
1085 1090 342474PRTHomo sapiens 342Met Lys Arg Val Leu Val Leu Leu
Leu Ala Val Ala Phe Gly His Ala 1 5 10 15 Leu Glu Arg Gly Arg Asp
Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 20 25 30 Ser His Leu Gly
Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 35 40 45 Ser Arg
Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 50 55 60
Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 65
70 75 80 Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys
Ser Cys 85 90 95 Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr
Ala Glu Cys Cys 100 105 110 Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys
Met Ala Ala Leu Lys His 115 120 125 Gln Pro Gln Glu Phe Pro Thr Tyr
Val Glu Pro Thr Asn Asp Glu Ile 130 135 140 Cys Glu Ala Phe Arg Lys
Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 145 150 155 160 Trp Glu Tyr
Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 165 170 175 Ser
Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 180 185
190 Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His
195 200 205 Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln
Tyr Ala 210 215 220 Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu
Ile Lys Leu Ala 225 230 235 240 Gln Lys Val Pro Thr Ala Asp Leu Glu
Asp Val Leu Pro Leu Ala Glu 245 250 255 Asp Ile Thr Asn Ile Leu Ser
Lys Cys Cys Glu Ser Ala Ser Glu Asp 260 265 270 Cys Met Ala Lys Glu
Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 275 280 285 Leu Ser Thr
Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 290 295 300 Ala
Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 305 310
315 320 Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys
Asp 325 330 335 Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu
Leu Ser Arg 340 345 350 Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys
Val Leu Glu Pro Thr 355 360 365 Leu Lys Ser Leu Gly Glu Cys Cys Asp
Val Glu Asp Ser Thr Thr Cys 370 375 380 Phe Asn Ala Lys Gly Pro Leu
Leu Lys Lys Glu Leu Ser Ser Phe Ile 385 390 395 400 Asp Lys Gly Gln
Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 405 410 415 Glu Tyr
Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Asp 420 425 430
Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys His Ser Asp Phe 435
440 445 Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp
Ser 450 455 460 Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu 465 470
343478PRTHomo sapiens 343Met Ala Pro Leu Arg Pro Leu Leu Ile Leu
Ala Leu Leu Ala Trp Val 1 5 10 15 Ala Leu Ala Asp Gln Glu Ser Cys
Lys Gly Arg Cys Thr Glu Gly Phe 20 25 30 Asn Val Asp Lys Lys Cys
Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln 35 40 45 Ser Cys Cys Thr
Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg 50 55 60 Gly Asp
Val Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp 65 70 75 80
Gly Glu Glu Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro 85
90 95 Ser Leu Thr Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu
Gln 100 105 110 Thr Pro Val Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro
Glu Val Gly 115 120 125 Ala Ser Lys Pro Glu Gly Ile Asp Ser Arg Pro
Glu Thr Leu His Pro 130 135 140 Gly Arg Pro Gln Pro Pro Ala Glu Glu
Glu Leu Cys Ser Gly Lys Pro 145 150 155 160 Phe Asp Ala Phe Thr Asp
Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg 165 170 175 Gly Gln Tyr Cys
Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr 180 185 190 Pro Lys
Leu Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala 195 200 205
Ala Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly 210
215 220 Ser Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr
Pro 225 230 235 240 Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp
Asn Val Asp Ala 245 250 255 Ala Leu Ala Leu Pro Ala His Ser Tyr Ser
Gly Arg Glu Arg Val Tyr 260 265 270 Phe Phe Lys Gly Lys Gln Tyr Trp
Glu Tyr Gln Phe Gln His Gln Pro 275 280 285 Ser Gln Glu Glu Cys Glu
Gly Ser Ser Leu Ser Ala Val Phe Glu His 290 295 300 Phe Ala Met Met
Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu 305 310 315 320 Phe
Trp Gly Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser 325 330
335 Arg Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly
340 345 350 Arg Ile Tyr Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala
Lys Lys 355 360 365 Gln Arg Phe Arg His Arg Asn Arg Lys Gly Tyr Arg
Ser Gln Arg Gly 370 375 380 His Ser Arg Gly Arg Asn Gln Asn Ser Arg
Arg Pro Ser Arg Ala Met 385 390 395 400 Trp Leu Ser Leu Phe Ser Ser
Glu Glu Ser Asn Leu Gly Ala Asn Asn 405 410 415 Tyr Asp Asp Tyr Arg
Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro 420 425 430 Ile Gln Ser
Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn 435 440 445 Leu
Arg Thr Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser 450 455
460 Ile Ala Gln Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu 465 470
475
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