U.S. patent application number 15/506050 was filed with the patent office on 2018-08-02 for synthon formation. This patent application is currently assigned to New England Biolabs, Inc.. The applicant listed for this patent is New England Biolabs, Inc.. Invention is credited to Theodore B. Davis, Thomas C. Evans, Jr., Andrew Gardner, Pei-Chung Hsieh, Luo Sun.
Application Number | 20180216098 15/506050 |
Document ID | / |
Family ID | 54140658 |
Filed Date | 2018-08-02 |
United States Patent Application | 20180216098 |
Kind Code | A1 |
Hsieh; Pei-Chung ; et al. | August 2, 2018 |
This disclosure provides, among other things, a composition comprising: a 5' exonuclease; a strand-displacing polymerase; and optionally a single strand DNA binding protein and/or a ligase. A method for polynucleotide assembly to form a synthon, as well as a kit for performing the same, are also described.
Inventors: | Hsieh; Pei-Chung; (Topsfield, MA) ; Sun; Luo; (Hamilton, MA) ; Evans, Jr.; Thomas C.; (Topsfield, MA) ; Davis; Theodore B.; (Boxford, MA) ; Gardner; Andrew; (Manchester, MA) | ||||||||||
Applicant: |
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Assignee: | New England Biolabs, Inc. Ipswich MA |
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Family ID: | 54140658 | ||||||||||
Appl. No.: | 15/506050 | ||||||||||
Filed: | August 27, 2015 | ||||||||||
PCT Filed: | August 27, 2015 | ||||||||||
PCT NO: | PCT/US15/47161 | ||||||||||
371 Date: | February 23, 2017 |
Application Number | Filing Date | Patent Number | ||
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62042527 | Aug 27, 2014 | |||
62189599 | Jul 7, 2015 | |||
62193168 | Jul 16, 2015 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | C12N 9/1252 20130101; C12N 15/66 20130101; C12N 9/96 20130101; C12N 15/1031 20130101; C12N 15/1027 20130101; C12Y 207/07007 20130101; C12N 2310/20 20170501; C07K 2319/00 20130101; C12P 19/34 20130101; C12N 15/64 20130101 |
International Class: | C12N 15/10 20060101 C12N015/10; C12N 15/64 20060101 C12N015/64; C12N 15/66 20060101 C12N015/66; C12N 9/12 20060101 C12N009/12; C12N 9/96 20060101 C12N009/96 |
Sequence CWU 1
1
1021775PRTArtificial SequenceSynthetic construct 1Met Ile Leu Asp
Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 1 5 10 15 Arg Leu
Phe Lys Lys Glu Asn Gly Arg Phe Lys Val Glu Tyr Asp Arg 20 25 30
Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 35
40 45 Asp Asp Val Arg Lys Ile Thr Ser Glu Arg His Gly Lys Val Val
Arg 50 55 60 Val Ile Asp Val Glu Lys Val Lys Lys Lys Phe Leu Gly
Arg Pro Ile 65 70 75 80 Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln
Asp Val Pro Ala Met 85 90 95 Arg Asp Lys Ile Arg Glu His Pro Ala
Val Ile Asp Ile Phe Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg
Tyr Leu Ile Asp Lys Gly Leu Ile Pro 115 120 125 Met Glu Gly Asn Glu
Glu Leu Thr Phe Leu Ala Val Asp Ile Glu Thr 130 135 140 Leu Tyr His
Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 145 150 155 160
Ser Tyr Ala Asp Glu Glu Gly Ala Lys Val Ile Thr Trp Lys Lys Ile 165
170 175 Asp Leu Pro Tyr Val Glu Val Val Ala Asn Glu Arg Glu Met Ile
Lys 180 185 190 Arg Leu Ile Lys Val Ile Arg Glu Lys Asp Pro Asp Val
Ile Ile Thr 195 200 205 Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu
Leu Lys Arg Ala Glu 210 215 220 Lys Leu Gly Met Lys Leu Pro Leu Gly
Arg Asp Asn Ser Glu Pro Lys 225 230 235 240 Met Gln Arg Leu Gly Asp
Ser Leu Ala Val Glu Ile Lys Gly Arg Ile 245 250 255 His Phe Asp Leu
Phe Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 260 265 270 Tyr Thr
Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Gln Lys Glu 275 280 285
Lys Val Tyr Pro His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 290
295 300 Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr
Tyr 305 310 315 320 Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln
Leu Ala Arg Leu 325 330 335 Val Gly Gln Pro Leu Trp Asp Val Ser Arg
Ser Ser Thr Gly Asn Leu 340 345 350 Val Glu Trp Tyr Leu Leu Arg Lys
Ala Tyr Glu Arg Asn Glu Leu Ala 355 360 365 Pro Asn Lys Pro Asp Glu
Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 370 375 380 Tyr Glu Gly Gly
Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Gly 385 390 395 400 Ile
Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 405 410
415 His Asn Val Ser Pro Asp Thr Leu Asn Lys Glu Gly Cys Gly Glu Tyr
420 425 430 Asp Glu Ala Pro Glu Val Gly His Arg Phe Cys Lys Asp Phe
Pro Gly 435 440 445 Phe Ile Pro Ser Leu Leu Gly Ser Leu Leu Glu Glu
Arg Gln Lys Ile 450 455 460 Lys Lys Arg Met Lys Glu Ser Lys Asp Pro
Val Glu Arg Lys Leu Leu 465 470 475 480 Asp Tyr Arg Gln Arg Ala Ile
Lys Ile Leu Ala Asn Ser Phe Tyr Gly 485 490 495 Tyr Tyr Gly Tyr Ala
Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 500 505 510 Ser Val Thr
Ala Trp Gly Arg Gln Tyr Ile Glu Leu Val Arg Arg Glu 515 520 525 Leu
Glu Glu Arg Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly Leu 530 535
540 Tyr Ala Thr Ile Pro Gly Glu Lys Asn Trp Glu Glu Ile Lys Arg Arg
545 550 555 560 Ala Leu Glu Phe Val Asn Tyr Ile Asn Ser Lys Leu Pro
Gly Ile Leu 565 570 575 Glu Leu Glu Tyr Glu Gly Phe Tyr Thr Arg Gly
Phe Phe Val Thr Lys 580 585 590 Lys Lys Tyr Ala Leu Ile Asp Glu Glu
Gly Lys Ile Val Thr Arg Gly 595 600 605 Leu Glu Ile Val Arg Arg Asp
Trp Ser Glu Ile Ala Lys Glu Thr Gln 610 615 620 Ala Lys Val Leu Glu
Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 625 630 635 640 Val Lys
Ile Val Lys Glu Val Thr Glu Lys Leu Ser Asn Tyr Glu Ile 645 650 655
Pro Val Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu Asn 660
665 670 Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu
Ala 675 680 685 Ala Lys Gly Ile Lys Ile Lys Pro Gly Met Val Ile Gly
Tyr Val Val 690 695 700 Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala
Ile Ala Ile Glu Glu 705 710 715 720 Phe Asp Gly Lys Lys His Lys Tyr
Asp Ala Glu Tyr Tyr Ile Glu Asn 725 730 735 Gln Val Leu Pro Ala Val
Glu Arg Ile Leu Lys Ala Phe Gly Tyr Lys 740 745 750 Arg Glu Asp Leu
Arg Trp Gln Lys Thr Lys Gln Val Gly Leu Gly Ala 755 760 765 Trp Leu
Lys Val Lys Lys Ser 770 775 275PRTPyrococcus furiosus 2Ile Ile Asn
Pro Gln Ala Arg Leu Thr Pro Leu Glu Leu Glu Ile Leu 1 5 10 15 Glu
Ile Ile Lys Gln Lys Lys Ser Ile Thr Ile Thr Glu Ile Lys Glu 20 25
30 Ile Leu Ser Glu Arg Arg Lys Ser Glu Tyr Pro Leu Ser Leu Val Ser
35 40 45 Glu Tyr Ile Ser Arg Leu Glu Arg Lys Gly Tyr Val Lys Lys
Ile Ala 50 55 60 Lys Gly Arg Lys Lys Phe Val Glu Ala Leu Ile 65 70
75 3856PRTArtificial SequenceSynthetic construct 3Met Ile Leu Asp
Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 1 5 10 15 Arg Leu
Phe Lys Lys Glu Asn Gly Arg Phe Lys Val Glu Tyr Asp Arg 20 25 30
Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 35
40 45 Asp Asp Val Arg Lys Ile Thr Ser Glu Arg His Gly Lys Val Val
Arg 50 55 60 Val Ile Asp Val Glu Lys Val Lys Lys Lys Phe Leu Gly
Arg Pro Ile 65 70 75 80 Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln
Asp Val Pro Ala Met 85 90 95 Arg Asp Lys Ile Arg Glu His Pro Ala
Val Ile Asp Ile Phe Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg
Tyr Leu Ile Asp Lys Gly Leu Ile Pro 115 120 125 Met Glu Gly Asn Glu
Glu Leu Thr Phe Leu Ala Val Asp Ile Glu Thr 130 135 140 Leu Tyr His
Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 145 150 155 160
Ser Tyr Ala Asp Glu Glu Gly Ala Lys Val Ile Thr Trp Lys Lys Ile 165
170 175 Asp Leu Pro Tyr Val Glu Val Val Ala Asn Glu Arg Glu Met Ile
Lys 180 185 190 Arg Leu Ile Lys Val Ile Arg Glu Lys Asp Pro Asp Val
Ile Ile Thr 195 200 205 Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu
Leu Lys Arg Ala Glu 210 215 220 Lys Leu Gly Met Lys Leu Pro Leu Gly
Arg Asp Asn Ser Glu Pro Lys 225 230 235 240 Met Gln Arg Leu Gly Asp
Ser Leu Ala Val Glu Ile Lys Gly Arg Ile 245 250 255 His Phe Asp Leu
Phe Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 260 265 270 Tyr Thr
Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Gln Lys Glu 275 280 285
Lys Val Tyr Pro His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 290
295 300 Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr
Tyr 305 310 315 320 Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln
Leu Ala Arg Leu 325 330 335 Val Gly Gln Pro Leu Trp Asp Val Ser Arg
Ser Ser Thr Gly Asn Leu 340 345 350 Val Glu Trp Tyr Leu Leu Arg Lys
Ala Tyr Glu Arg Asn Glu Leu Ala 355 360 365 Pro Asn Lys Pro Asp Glu
Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 370 375 380 Tyr Glu Gly Gly
Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Gly 385 390 395 400 Ile
Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 405 410
415 His Asn Val Ser Pro Asp Thr Leu Asn Lys Glu Gly Cys Gly Glu Tyr
420 425 430 Asp Glu Ala Pro Glu Val Gly His Arg Phe Cys Lys Asp Phe
Pro Gly 435 440 445 Phe Ile Pro Ser Leu Leu Gly Ser Leu Leu Glu Glu
Arg Gln Lys Ile 450 455 460 Lys Lys Arg Met Lys Glu Ser Lys Asp Pro
Val Glu Arg Lys Leu Leu 465 470 475 480 Asp Tyr Arg Gln Arg Ala Ile
Lys Ile Leu Ala Asn Ser Phe Tyr Gly 485 490 495 Tyr Tyr Gly Tyr Ala
Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 500 505 510 Ser Val Thr
Ala Trp Gly Arg Gln Tyr Ile Glu Leu Val Arg Arg Glu 515 520 525 Leu
Glu Glu Arg Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly Leu 530 535
540 Tyr Ala Thr Ile Pro Gly Glu Lys Asn Trp Glu Glu Ile Lys Arg Arg
545 550 555 560 Ala Leu Glu Phe Val Asn Tyr Ile Asn Ser Lys Leu Pro
Gly Ile Leu 565 570 575 Glu Leu Glu Tyr Glu Gly Phe Tyr Thr Arg Gly
Phe Phe Val Thr Lys 580 585 590 Lys Lys Tyr Ala Leu Ile Asp Glu Glu
Gly Lys Ile Val Thr Arg Gly 595 600 605 Leu Glu Ile Val Arg Arg Asp
Trp Ser Glu Ile Ala Lys Glu Thr Gln 610 615 620 Ala Lys Val Leu Glu
Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 625 630 635 640 Val Lys
Ile Val Lys Glu Val Thr Glu Lys Leu Ser Asn Tyr Glu Ile 645 650 655
Pro Val Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu Asn 660
665 670 Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu
Ala 675 680 685 Ala Lys Gly Ile Lys Ile Lys Pro Gly Met Val Ile Gly
Tyr Val Val 690 695 700 Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala
Ile Ala Ile Glu Glu 705 710 715 720 Phe Asp Gly Lys Lys His Lys Tyr
Asp Ala Glu Tyr Tyr Ile Glu Asn 725 730 735 Gln Val Leu Pro Ala Val
Glu Arg Ile Leu Lys Ala Phe Gly Tyr Lys 740 745 750 Arg Glu Asp Leu
Arg Trp Gln Lys Thr Lys Gln Val Gly Leu Gly Ala 755 760 765 Trp Leu
Lys Val Lys Lys Ser Gly Thr Gly Gly Gly Gly Ile Ile Asn 770 775 780
Pro Gln Ala Arg Leu Thr Pro Leu Glu Leu Glu Ile Leu Glu Ile Ile 785
790 795 800 Lys Gln Lys Lys Ser Ile Thr Ile Thr Glu Ile Lys Glu Ile
Leu Ser 805 810 815 Glu Arg Arg Lys Ser Glu Tyr Pro Leu Ser Leu Val
Ser Glu Tyr Ile 820 825 830 Ser Arg Leu Glu Arg Lys Gly Tyr Val Lys
Lys Ile Ala Lys Gly Arg 835 840 845 Lys Lys Phe Val Glu Ala Leu Ile
850 855 440DNAArtificial SequenceSynthetic construct 4ttggtctggt
gtcaaaaatg aatcgtcacg gcgatttatg 40539DNAArtificial
SequenceSynthetic construct 5gggtcatttt cggcgaggac tgcatcaacg
catatagcg 39632DNAArtificial SequenceSynthetic construct
6gcggccgcgt cctcgccgaa aatgacccag ag 32732DNAArtificial
SequenceSynthetic construct 7gcggccgctg gtgtcgatgg tagaacgaag cg
32832DNAArtificial SequenceSynthetic construct 8gcggccgccc
cactgacgcg ttgcgcgaga ag 32932DNAArtificial SequenceSynthetic
construct 9gcggccgcgg ctgcgcaact gttgggaagg gc 321032DNAArtificial
SequenceSynthetic construct 10gcggccgctg cagcacatcc ccctttcgcc ag
321132DNAArtificial SequenceSynthetic construct 11gcggccgcat
gatgctcgtg acggttaacg cc 321232DNAArtificial SequenceSynthetic
construct 12gcggccgcag gtgcggattg aaaatggtct gc 321332DNAArtificial
SequenceSynthetic construct 13gcggccgctc accgcttgcc agcggcttac ca
321432DNAArtificial SequenceSynthetic construct 14gcggccgcga
atacctgttc cgtcatagcg at 321533DNAArtificial SequenceSynthetic
construct 15gcggccgctc atttttgaca ccagaccaac tgg
33161016DNAArtificial SequenceSynthetic construct 16gcggccgcgt
cctcgccgaa aatgacccag agcgctgccg gcacctgtcc tacgagttgc 60atgataaaga
agacagtcat aagtgcggcg acgatagtca tgccccgcgc ccaccggaag
120gagctgactg ggttgaaggc tctcaagggc atcggtcgag atcccggtgc
ctaatgagtg 180agctaactta cattaattgc gttgcgctca ctgcccgctt
tccagtcggg aaacctgtcg 240tgccagctgc attaatgaat cggccaacgc
gcggggagag gcggtttgcg tattgggcgc 300cagggtggtt tttcttttca
ccagtgagac gggcaacagc tgattgccct tcaccgcctg 360gccctgagag
agttgcagca agcggtccac gctggtttgc cccagcaggc gaaaatcctg
420tttgatggtg gttaacggcg ggatataacc aacgcgcagc ccggactcgg
taatatccca 480ctaccgagat atccgcacca acgcgcagcc cggactcggt
aatggcgcgc attgcgccca 540gcgccatctg atcgttggca accagcatcg
cagtgggaac gatgccctca ttcagcattt 600gcatggtttg ttgaaaaccg
gacatggcac tccagtcgcc ttcccgttcc gctatcggct 660gaatttgatt
gcgagtgaga tatttatgcc agccagccag acgcagacgc gccgagacag
720aacttaatgg gcccgctaac agcgcgattt gctggtgacc caatgcgacc
agatgctcca 780cgcccagtcg cgtaccgtct tcatgggaga aaataatact
gttgatgggt gtctggtcag 840agacatcaag aaataacgcc ggaacattag
tgcaggcagc ttccacagca atggcatcct 900ggtcatccag cggatagtta
atgatcagcc cactgacgcg ttgcgcgaga agattgtgca 960ccgccgcttt
acaggcttcg acgccgcttc gttctaccat cgacaccagc ggccgc
1016171016DNAArtificial SequenceSynthetic construct 17gcggccgccc
cactgacgcg ttgcgcgaga agattgtgca ccgccgcttt acaggcttcg 60acgccgcttc
gttctaccat cgacaccacc acgctggcac ccagttgatc ggcgcgagat
120ttaatcgccg cgacaatttg cgacggcgcg tgcagggcca gactggaggt
ggcaacgcca 180atcagcaacg actgtttgcc cgccagttgt tgtgccacgc
ggttgggaat gtaattcagc 240tccgccatcg ccgcttccac tttttcccgc
gttttcgcag aaacgtggct ggcctggttc 300accacgcggg aaacggtctg
ataagagaca ccggcatact ctgcgacatc gtataacgtt 360actggtttca
cattcaccac cctgaattga ctctcttccg ggcgctatca tgccataccg
420cgaaaggttt tgcgccattc gatggtgtcc gggatctcga cgctctccct
tatgcgactc 480ctgcattagg aagcagccca gtagtaggtt gaggccgttg
agcaccgccg ccgcaaggaa 540tggtgcatgc aaggagatgg cgcccaacag
tcccccggcc acggggcctg ccaccatacc 600cacgccgaaa caagcgctca
tgagcccgaa gtggcgagcc cgatcttccc catcggtgat 660gtcggcgata
taggcgccag caaccgcacc tgtggcgccg gtgatgccgg ccacgatgcg
720tccggcgtag aggatcgaga tctcgatccc gcgaaattaa tacgactcac
tataggggaa 780ttgtgagcgg ataacaattc ccctctagaa ataattttgt
ttaactttaa gaaggagata 840tacatatgac catgattacg gattcactgg
ccgtcgtttt acaacgtcgt gactgggaaa 900accctggcgt tacccaactt
aatcgccttg cagcacatcc ccctttcgcc agctggcgta 960atagcgaaga
ggcccgcacc gatcgccctt cccaacagtt gcgcagccgc ggccgc
1016181016DNAArtificial SequenceSynthetic construct 18gcggccgctg
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc 60gatcgccctt
cccaacagtt gcgcagcctg aatggcgaat ggcgctttgc ctggtttccg
120gcaccagaag cggtgccgga aagctggctg gagtgcgatc ttcctgaggc
cgatactgtc 180gtcgtcccct caaactggca gatgcacggt tacgatgcgc
ccatctacac caacgtgacc 240tatcccatta cggtcaatcc gccgtttgtt
cccacggaga atccgacggg ttgttactcg 300ctcacattta atgttgatga
aagctggcta caggaaggcc agacgcgaat tatttttgat 360ggcgttaact
cggcgtttca tctgtggtgc aacgggcgct gggtcggtta cggccaggac
420agtcgtttgc cgtctgaatt tgacctgagc gcatttttac gcgccggaga
aaaccgcctc 480gcggtgatgg tgctgcgctg gagtgacggc agttatctgg
aagatcagga tatgtggcgg 540atgagcggca ttttccgtga cgtctcgttg
ctgcataaac cgactacaca aatcagcgat 600ttccatgttg ccactcgctt
taatgatgat ttcagccgcg ctgtactgga ggctgaagtt 660cagatgtgcg
gcgagttgcg tgactaccta cgggtaacag tttctttatg gcagggtgaa
720acgcaggtcg ccagcggcac cgcgcctttc ggcggtgaaa ttatcgatga
gcgtggtggt 780tatgccgatc gcgtcacact acgtctgaac gtcgaaaacc
cgaaactgtg gagcgccgaa 840atcccgaatc tctatcgtgc ggtggttgaa
ctgcacaccg ccgacggcac gctgattgaa 900gcagaagcct gcgatgtcgg
tttccgcgag gtgcggattg aaaatggtct gctgctgctg 960aacggcaagc
cgttgctgat tcgaggcgtt aaccgtcacg agcatcatgc ggccgc
1016191016DNAArtificial SequenceSynthetic construct 19gcggccgcag
gtgcggattg aaaatggtct gctgctgctg aacggcaagc cgttgctgat 60tcgaggcgtt
aaccgtcacg agcatcatcc tctgcatggt caggtcatgg atgagcagac
120gatggtgcag gatatcctgc tgatgaagca gaacaacttt aacgccgtgc
gctgttcgca 180ttatccgaac catccgctgt ggtacacgct gtgcgaccgc
tacggcctgt atgtggtgga 240tgaagccaat attgaaaccc acggcatggt
gccaatgaat cgtctgaccg atgatccgcg 300ctggctaccg gcgatgagcg
aacgcgtaac gcgaatggtg cagcgcgatc gtaatcaccc 360gagtgtgatc
atctggtcgc tggggaatga atcaggccac ggcgctaatc acgacgcgct
420gtatcgctgg atcaaatctg tcgatccttc ccgcccggtg cagtatgaag
gcggcggagc 480cgacaccacg gccaccgata ttatttgccc gatgtacgcg
cgcgtggatg aagaccagcc 540cttcccggct gtgccgaaat ggtccatcaa
aaaatggctt tcgctacctg gagagacgcg 600cccgctgatc ctttgcgaat
acgcccacgc gatgggtaac agtcttggcg gtttcgctaa 660atactggcag
gcgtttcgtc agtatccccg tttacagggc ggcttcgtct gggactgggt
720ggatcagtcg ctgattaaat atgatgaaaa cggcaacccg tggtcggctt
acggcggtga 780ttttggcgat acgccgaacg atcgccagtt ctgtatgaac
ggtctggtct ttgccgaccg 840cacgccgcat ccagcgctga cggaagcaaa
acaccagcag cagtttttcc agttccgttt 900atccgggcaa accatcgaag
tgaccagcga atacctgttc cgtcatagcg ataacgagct 960cctgcactgg
atggtggcgc tggatggtaa gccgctggca agcggtgagc ggccgc
1016201168DNAArtificial SequenceSynthetic construct 20gcggccgcga
atacctgttc cgtcatagcg ataacgagct cctgcactgg atggtggcgc 60tggatggtaa
gccgctggca agcggtgaag tgcctctgga tgtcgctcca caaggtaaac
120agttgattga actgcctgaa ctaccgcagc cggagagcgc cgggcaactc
tggctcacag 180tacgcgtagt gcaaccgaac gcgaccgcat ggtcagaagc
cgggcacatc agcgcctggc 240agcagtggcg tctggcggaa aacctcagtg
tgacgctccc cgccgcgtcc cacgccatcc 300cgcatctgac caccagcgaa
atggattttt gcatcgagct gggtaataag cgttggcaat 360ttaaccgcca
gtcaggcttt ctttcacaga tgtggattgg cgataaaaaa caactgctga
420cgccgctgcg cgatcagttc acccgtgcac cgctggataa cgacattggc
gtaagtgaag 480cgacccgcat tgaccctaac gcctgggtcg aacgctggaa
ggcggcgggc cattaccagg 540ccgaagcagc gttgttgcag tgcacggcag
atacacttgc tgatgcggtg ctgattacga 600ccgctcacgc gtggcagcat
caggggaaaa ccttatttat cagccggaaa acctaccgga 660ttgatggtag
tggtcaaatg gcgattaccg ttgatgttga agtggcgagc gatacaccgc
720atccggcgcg gattggcctg aactgccagc tggcgcaggt agcagagcgg
gtaaactggc 780tcggattagg gccgcaagaa aactatcccg accgccttac
tgccgcctgt tttgaccgct 840gggatctgcc attgtcagac atgtataccc
cgtacgtctt cccgagcgaa aacggtctgc 900gctgcgggac gcgcgaattg
aattatggcc cacaccagtg gcgcggcgac ttccagttca 960acatcagccg
ctacagtcaa cagcaactga tggaaaccag ccatcgccat ctgctgcacg
1020cggaagaagg cacatggctg aatatcgacg gtttccatat ggggattggt
ggcgacgact 1080cctggagccc gtcagtatcg gcggaattcc agctgagcgc
cggtcgctac cattaccagt 1140tggtctggtg tcaaaaatga gcggccgc
11682124DNAArtificial SequenceSynthetic construct 21aaaaccaccc
tggcgcccaa tacg 242224DNAArtificial SequenceSynthetic construct
22cccggactcg gtaatggcgc gcat 242324DNAArtificial SequenceSynthetic
construct 23ggaagcagcc cagtagtagg ttga 242424DNAArtificial
SequenceSynthetic construct 24ggtgctgcgc tggagtgacg gcag
242524DNAArtificial SequenceSynthetic construct 25cggccaccga
tattatttgc ccga 242624DNAArtificial SequenceSynthetic construct
26gattagggcc gcaagaaaac tatc 242724DNAArtificial SequenceSynthetic
constructmisc_feature(22)..(22)n is a, c, g, or t 27gcgaagaacc
tcttcccaag angg 242871DNAArtificial SequenceSynthetic construct
28atcttgtgga aaggacgaaa caccggcgaa gaacctcttc ccaagagttt tagagctaga
60aatagcaagt t 712971DNAArtificial SequenceSynthetic
constructmisc_feature(26)..(46)n is a, c, g, or t 29atcttgtgga
aaggacgaaa caccgnnnnn nnnnnnnnnn nnnnnngttt tagagctaga 60aatagcaagt
t 713024DNAArtificial SequenceSynthetic construct 30cgccagggtt
ttcccagtca cgac 243127DNAArtificial SequenceSynthetic construct
31gccaagcttg catgcctgca ggtcgac 273271DNAArtificial
SequenceSynthetic construct 32gcggtcccaa aagggtcagt gctgcaacat
tttgctgccg gtcacggttc gaacgtacgg 60acgtccagct g
71331184PRTMethanocaldococcus vulcanius 33Met Lys Glu Lys Ala Pro
Lys Ile Asp Ala Leu Ile Asp Cys Thr Tyr 1 5 10 15 Lys Thr Glu Asp
Asn Arg Ala Val Ile Tyr Leu Tyr Leu Leu Glu Asn 20 25 30 Ile Leu
Lys Asp Arg Glu Phe Ser Pro Tyr Phe Tyr Val Glu Met Leu 35 40 45
Lys Asp Arg Ile Glu Lys Glu Asp Ile Asp Lys Ile Lys Glu Phe Leu 50
55 60 Leu Lys Glu Asp Leu Leu Lys Phe Val Glu Asn Leu Glu Val Val
Asn 65 70 75 80 Lys Thr Ile Leu Lys Lys Glu Lys Glu Ile Val Lys Ile
Ile Ala Thr 85 90 95 His Pro Gln Arg Val Pro Lys Leu Arg Lys Ile
Lys Glu Cys Asp Ile 100 105 110 Val Lys Glu Ile Tyr Glu His Asp Ile
Pro Phe Ala Lys Arg Tyr Leu 115 120 125 Ile Asp Ser Asp Ile Val Pro
Met Thr Tyr Trp Asp Phe Glu Asn Arg 130 135 140 Lys Gln Val Ser Ile
Glu Ile Pro Lys Leu Lys Thr Val Ser Phe Asp 145 150 155 160 Met Glu
Val Tyr Asn Arg Asp Thr Glu Pro Asp Pro Glu Lys Asp Pro 165 170 175
Ile Leu Met Ala Ser Phe Trp Asp Asp Asn Gly Gly Lys Val Ile Thr 180
185 190 Tyr Lys His Phe Asp His Ser Asn Ile Glu Val Val Asn Ser Glu
Lys 195 200 205 Asp Leu Ile Lys Lys Ile Val Glu Met Leu Arg Gln Tyr
Asp Val Ile 210 215 220 Phe Thr Tyr Asn Gly Asp Asn Phe Asp Phe Pro
Tyr Leu Lys Ala Arg 225 230 235 240 Ala Lys Ile Tyr Gly Ile Asp Ile
Lys Leu Gly Arg Asp Gly Glu Glu 245 250 255 Leu Lys Ile Lys Arg Gly
Gly Met Glu Phe Arg Ser Tyr Ile Pro Gly 260 265 270 Arg Val His Ile
Asp Leu Tyr Pro Ile Ser Arg Arg Leu Leu Lys Leu 275 280 285 Thr Lys
Tyr Thr Leu Glu Asp Val Val Tyr Asn Leu Phe Gly Ile Glu 290 295 300
Lys Leu Lys Ile Pro His Thr Lys Ile Val Asp Tyr Trp Ala Asn Asn 305
310 315 320 Asp Lys Ile Leu Ile Glu Tyr Ser Leu Gln Asp Ala Lys Tyr
Thr His 325 330 335 Lys Ile Gly Lys Tyr Phe Phe Pro Leu Glu Val Met
Phe Ser Arg Ile 340 345 350 Val Asn Gln Thr Pro Phe Glu Ile Thr Arg
Met Ser Ser Gly Gln Met 355 360 365 Val Glu Tyr Leu Leu Met Lys Asn
Ala Phe Lys Glu Asn Met Ile Val 370 375 380 Pro Asn Lys Pro Asp Glu
Lys Glu Tyr Arg Lys Arg Leu Leu Thr Ser 385 390 395 400 Tyr Glu Gly
Gly Tyr Val Lys Glu Pro Glu Lys Gly Met Phe Glu Asp 405 410 415 Ile
Ile Ser Met Asp Phe Arg Cys His Pro Arg Gly Thr Lys Val Ile 420 425
430 Val Lys Asn Asn Gly Leu Thr Asp Ile Glu Asn Val Lys Val Gly Asp
435 440 445 Tyr Val Leu Gly Ile Asp Gly Trp Gln Lys Val Lys Arg Val
Trp Lys 450 455 460 Tyr Pro Tyr Asn Gly Phe Leu Val Asn Val Asn Gly
Leu Lys Ser Thr 465 470 475 480 Pro Asn His Lys Ile Pro Val Ile Lys
Lys Glu Asn Gly Lys Asp Arg 485 490 495 Val Ile Asp Val Ser Ser Ile
Tyr Leu Leu Asn Leu Lys Gly Cys Lys 500 505 510 Ile Leu Lys Ile Lys
Asn Phe Glu Ser Ile Gly Met Phe Gly Lys Ile 515 520 525 Phe Lys Lys
Asp Thr Lys Ile Lys Lys Val Lys Gly Leu Leu Glu Lys 530 535 540 Ile
Ala Tyr Ile Asp Pro Arg Glu Gly Leu Val Ile Lys Val Lys Asn 545 550
555 560 Glu Lys Glu Asp Ile Phe Lys Thr Val Ile Pro Ile Leu Lys Glu
Leu 565 570 575 Asn Ile Leu Tyr Lys Gln Val Asp Glu Lys Thr Ile Ile
Ile Asp Ser 580 585 590 Ile Asp Gly Leu Leu Lys Tyr Ile Val Thr Ile
Gly Phe Asn Asp Lys 595 600 605 Asn Glu Glu Lys Ile Lys Glu Ile Ile
Lys Glu Lys Ser Phe Leu Glu 610 615 620 Phe Lys Glu Leu Glu Asp Ile
Lys Ile Ser Ile Glu Glu Tyr Glu Gly 625 630 635 640 Tyr Val Tyr Asp
Leu Thr Leu Glu Gly Arg Pro Tyr Tyr Phe Ala Asn 645 650 655 Gly Ile
Leu Thr His Asn Ser Leu Tyr Pro Ser Ile Ile Ile Ala Tyr 660 665 670
Asn Ile Ser Pro Glu Thr Leu Asp Cys Glu Cys Cys Lys Asp Ile Ser 675
680 685 Glu Lys Ile Leu Gly His Trp Phe Cys Lys Lys Arg Glu Gly Leu
Ile 690 695 700 Pro Lys Thr Leu Arg Gly Leu Ile Glu Arg Arg Ile Asn
Ile Lys Asn 705 710 715 720 Lys Met Lys Lys Met Glu Ser Glu Lys Glu
Ile Asn Glu Glu Tyr Asn 725 730 735 Leu Leu Asp Tyr Glu Gln Arg Ser
Leu Lys Ile Leu Ala Asn Ser Val 740 745 750 Tyr Gly Tyr Leu Ala Phe
Pro Arg Ala Arg Phe Tyr Ser Arg Glu Cys 755 760 765 Ala Glu Val Ile
Thr Tyr Leu Gly Arg Lys Tyr Ile Leu Glu Thr Ile 770 775 780 Glu Glu
Ala Glu Lys Phe Gly Phe Lys Val Ile Tyr Ala Asp Ser Val 785 790 795
800 Val Lys Asp Ala Lys Val Ile Ile Lys Glu Asp Gly Lys Ile Lys Glu
805 810 815 Ile Lys Ile Glu Asp Leu Phe Lys Lys Val Asp Tyr Thr Ile
Gly Asp 820 825 830 Lys Glu Tyr Cys Ile Leu Asn Asn Val Glu Thr Leu
Thr Ile Glu Asp 835 840 845 Thr Lys Leu Val Trp Arg Lys Val Pro Tyr
Ile Met Arg His Arg Thr 850 855 860 Asn Lys Lys Ile Tyr Arg Val Lys
Val Lys Asp Arg Tyr Val Asp Ile 865 870 875 880 Thr Glu Asp His Ser
Ile Ile Gly Val Lys Asn Asn Lys Leu Val Glu 885 890 895 Leu Lys Pro
Thr Glu Ile Lys Asp Asp Glu Thr Lys Leu Ile Ile Leu 900 905 910 Asn
Lys Asp Leu Lys Ser Tyr Asn Phe Ala Ser Val Glu Glu Ile Asn 915 920
925 Cys Ile Lys Tyr Ser Asp Tyr Val Tyr Asp Ile Glu Val Glu Asn Thr
930 935 940 His Arg Phe Phe Ala Asn Gly Ile Leu Val His Asn Thr Asp
Gly Phe 945 950 955 960 Tyr Ala Val Trp Lys Glu Lys Ile Ser Lys Asp
Asp Leu Ile Lys Lys 965 970 975 Ala Leu Glu Phe Val Lys Tyr Ile Asn
Ser Lys Leu Pro Gly Thr Met 980 985 990 Glu Leu Glu Phe Glu Gly Tyr
Phe Lys Arg Gly Ile Phe Ile Thr Lys 995 1000 1005 Lys Arg Tyr Ala
Leu Ile Asp Glu Asn Gly Arg Val Ile Val Lys 1010 1015 1020 Gly Leu
Glu Phe Val Arg Arg Asp Trp Ser Asn Leu Ala Arg Ile 1025 1030 1035
Thr Gln Arg Arg Val Leu Glu Ala Leu Leu Leu Glu Gly Asp Ile 1040
1045 1050 Asn Lys Ala Lys Lys Ala Ile Gln Asp Val Ile Lys Asp Leu
Arg 1055 1060 1065 Glu Lys Lys Ile Lys Lys Glu Asp Leu Ile Ile Tyr
Thr Gln Leu 1070 1075 1080 Thr Lys Asn Pro Asn Glu Tyr Lys Thr Thr
Ala Pro His Val Glu 1085 1090 1095 Ile Ala Lys Lys Met Met Arg Glu
Gly Lys Lys Ile Lys Ile Gly 1100 1105 1110 Asp Val Ile Gly Tyr Ile
Ile Val Lys Gly Ser Lys Ser Ile Ser 1115 1120 1125 Glu Arg Ala Lys
Leu Pro Glu Glu Val Ser Ile Glu Glu Ile Asp 1130 1135 1140 Val Asn
Tyr Tyr Ile Asp Asn Gln Ile Leu Pro Pro Val Leu Arg 1145 1150 1155
Ile Met Glu Ala Val Gly Val Ser Lys Asn Glu Leu Lys Lys Glu 1160
1165 1170 Gly Thr Gln Leu Thr Leu Asp Arg Phe Leu Lys 1175 1180
34781PRTArchaeoglobus fulgidus 34Met Glu Arg Val Glu Gly Trp Leu
Ile Asp Ala Asp Tyr Glu Thr Ile 1 5 10 15 Gly Gly Lys Ala Val Val
Arg Leu Trp Cys Lys Asp Asp Gln Gly Ile 20 25 30 Phe Val Ala Tyr
Asp Tyr Asn Phe Asp Pro Tyr Phe Tyr Val Ile Gly 35 40 45 Val Asp
Glu Asp Ile Leu Lys Asn Ala Ala Thr Ser Thr Arg Arg Glu 50 55 60
Val Ile Lys Leu Lys Ser Phe Glu Lys Ala Gln Leu Lys Thr Leu Gly 65
70 75 80 Arg Glu Val Glu Gly Tyr Ile Val Tyr Ala His His Pro Gln
His Val 85 90 95 Pro Lys Leu Arg Asp Tyr Leu Ser Gln Phe Gly Asp
Val Arg Glu Ala 100 105 110 Asp Ile Pro Phe Ala Tyr Arg Tyr Leu Ile
Asp Lys Asp Leu Ala Cys 115 120 125 Met Asp Gly Ile Ala Ile Glu Gly
Glu Lys Gln Gly Gly Val Ile Arg 130 135 140 Ser Tyr Lys Ile Glu Lys
Val Glu Arg Ile Pro Arg Met Glu Phe Pro 145 150 155 160 Glu Leu Lys
Met Leu Val Phe Asp Cys Glu Met Leu Ser Ser Phe Gly 165 170 175 Met
Pro Glu Pro Glu Lys Asp Pro Ile Ile Val Ile Ser Val Lys Thr 180 185
190 Asn Asp Asp Asp Glu Ile Ile Leu Thr Gly Asp Glu Arg Lys Ile Ile
195 200 205 Ser Asp Phe Val Lys Leu Ile Lys Ser Tyr Asp Pro Asp Ile
Ile Val 210 215 220 Gly Tyr Asn Gln Asp Ala Phe Asp Trp Pro Tyr Leu
Arg Lys Arg Ala 225 230 235 240 Glu Arg Trp Asn Ile Pro Leu Asp Val
Gly Arg Asp Gly Ser Asn Val 245 250 255 Val Phe Arg Gly Gly Arg Pro
Lys Ile Thr Gly Arg Leu Asn Val Asp 260 265 270 Leu Tyr Asp Ile Ala
Met Arg Ile Ser Asp Ile Lys Ile Lys Lys Leu 275 280 285 Glu Asn Val
Ala Glu Phe Leu Gly Thr Lys Ile Glu Ile Ala Asp Ile 290 295 300 Glu
Ala Lys Asp Ile Tyr Arg Tyr Trp Ser Arg Gly Glu Lys Glu Lys 305 310
315 320 Val Leu Asn Tyr Ala Arg Gln Asp Ala Ile Asn Thr Tyr Leu Ile
Ala 325 330 335 Lys Glu Leu Leu Pro Met His Tyr Glu Leu Ser Lys Met
Ile Arg Leu 340 345 350 Pro Val Asp Asp Val Thr Arg Met Gly Arg Gly
Lys Gln Val Asp Trp 355 360 365 Leu Leu Leu Ser Glu Ala Lys Lys Ile
Gly Glu Ile Ala Pro Asn Pro 370 375 380 Pro Glu His Ala Glu Ser Tyr
Glu Gly Ala Phe Val Leu Glu Pro Glu 385 390 395 400 Arg Gly Leu His
Glu Asn Val Ala Cys Leu Asp Phe Ala Ser Met Tyr 405 410 415 Pro Ser
Ile Met Ile Ala Phe Asn Ile Ser Pro Asp Thr Tyr Gly Cys 420
425 430 Arg Asp Asp Cys Tyr Glu Ala Pro Glu Val Gly His Lys Phe Arg
Lys 435 440 445 Ser Pro Asp Gly Phe Phe Lys Arg Ile Leu Arg Met Leu
Ile Glu Lys 450 455 460 Arg Arg Glu Leu Lys Val Glu Leu Lys Asn Leu
Ser Pro Glu Ser Ser 465 470 475 480 Glu Tyr Lys Leu Leu Asp Ile Lys
Gln Gln Thr Leu Lys Val Leu Thr 485 490 495 Asn Ser Phe Tyr Gly Tyr
Met Gly Trp Asn Leu Ala Arg Trp Tyr Cys 500 505 510 His Pro Cys Ala
Glu Ala Thr Thr Ala Trp Gly Arg His Phe Ile Arg 515 520 525 Thr Ser
Ala Lys Ile Ala Glu Ser Met Gly Phe Lys Val Leu Tyr Gly 530 535 540
Asp Thr Asp Ser Ile Phe Val Thr Lys Ala Gly Met Thr Lys Glu Asp 545
550 555 560 Val Asp Arg Leu Ile Asp Lys Leu His Glu Glu Leu Pro Ile
Gln Ile 565 570 575 Glu Val Asp Glu Tyr Tyr Ser Ala Ile Phe Phe Val
Glu Lys Lys Arg 580 585 590 Tyr Ala Gly Leu Thr Glu Asp Gly Arg Leu
Val Val Lys Gly Leu Glu 595 600 605 Val Arg Arg Gly Asp Trp Cys Glu
Leu Ala Lys Lys Val Gln Arg Glu 610 615 620 Val Ile Glu Val Ile Leu
Lys Glu Lys Asn Pro Glu Lys Ala Leu Ser 625 630 635 640 Leu Val Lys
Asp Val Ile Leu Arg Ile Lys Glu Gly Lys Val Ser Leu 645 650 655 Glu
Glu Val Val Ile Tyr Lys Gly Leu Thr Lys Lys Pro Ser Lys Tyr 660 665
670 Glu Ser Met Gln Ala His Val Lys Ala Ala Leu Lys Ala Arg Glu Met
675 680 685 Gly Ile Ile Tyr Pro Val Ser Ser Lys Ile Gly Tyr Val Ile
Val Lys 690 695 700 Gly Ser Gly Asn Ile Gly Asp Arg Ala Tyr Pro Ile
Asp Leu Ile Glu 705 710 715 720 Asp Phe Asp Gly Glu Asn Leu Arg Ile
Lys Thr Lys Ser Gly Ile Glu 725 730 735 Ile Lys Lys Leu Asp Lys Asp
Tyr Tyr Ile Asp Asn Gln Ile Ile Pro 740 745 750 Ser Val Leu Arg Ile
Leu Glu Arg Phe Gly Tyr Thr Glu Ala Ser Leu 755 760 765 Lys Gly Ser
Ser Gln Met Ser Leu Asp Ser Phe Phe Ser 770 775 780
35783PRTArchaeoglobus profundus 35Met Ile Lys Ala Trp Leu Leu Asp
Val Asp Tyr Val Thr Glu Asn Asp 1 5 10 15 Arg Ala Val Ile Arg Leu
Trp Cys Lys Asp Asp Lys Gly Val Phe Val 20 25 30 Ala Tyr Asp Arg
Asn Phe Leu Pro Tyr Phe Tyr Val Ile Gly Cys Lys 35 40 45 Ala Glu
Asp Val Met Lys Val Lys Val Arg Thr Asn Glu Gly Ile Ile 50 55 60
Thr Pro Leu Lys Val Glu Glu Ile Glu Ala Lys Ser Leu Gly Lys Pro 65
70 75 80 Ile Lys Ala Leu Lys Val Tyr Thr Arg His Pro Gln His Val
Pro Lys 85 90 95 Leu Arg Glu Glu Ile Lys Lys Phe Ala Glu Val Arg
Glu Ala Asp Ile 100 105 110 Pro Phe Ala Tyr Arg Tyr Leu Ile Asp Lys
Asp Leu Ala Cys Met Asp 115 120 125 Gly Ile Glu Ile Glu Pro Ile Ala
Val Lys Glu Gly Val Leu Arg Ala 130 135 140 Tyr Glu Val Arg Ser Val
Arg Arg Val Glu Lys Lys Gly Phe Pro Asp 145 150 155 160 Leu Lys Ile
Leu Ala Phe Asp Cys Glu Met Leu Ala Gln Phe Met Pro 165 170 175 Asp
Pro Glu Lys Asp Pro Ile Ile Ala Ile Ala Val Lys Cys Gly Asp 180 185
190 Phe Glu Glu Val Leu His Gly Asp Glu Arg Asp Ile Leu Arg Arg Phe
195 200 205 Val Ser Ile Ile Lys Glu Gln Asp Pro Asp Ile Ile Val Gly
Tyr Asn 210 215 220 Gln Asp Asn Phe Asp Trp Pro Tyr Val Lys Lys Arg
Ala Glu Lys Phe 225 230 235 240 Gly Ile Arg Leu Asp Ile Gly Arg Asp
Arg Ser Glu Ile Ser Phe Arg 245 250 255 Gly Gly Arg Pro Lys Ile Ala
Gly Arg Leu Asn Val Asp Leu Tyr Asp 260 265 270 Ile Ala Leu Lys Ile
Pro Asp Val Lys Ile Lys Thr Leu Lys Lys Val 275 280 285 Ala Glu Phe
Leu Gly Ala Lys Val Glu Glu Glu Asp Ile Glu Gly Arg 290 295 300 Asp
Ile Tyr Lys Cys Trp Met Arg Gly Glu Lys Glu Lys Val Phe Lys 305 310
315 320 His Val Leu Asn Asp Val Leu Thr Thr Tyr Arg Leu Ala Leu Glu
Leu 325 330 335 Leu Pro Met His Tyr Glu Leu Ser Arg Met Ile Arg Leu
Pro Leu Asp 340 345 350 Asp Val Ala Arg Leu Gly Arg Gly Lys Gln Val
Asp Tyr Phe Leu Leu 355 360 365 Ser Glu Ala Lys Lys Ile Asn Glu Ile
Ala Pro Asn Pro Pro Glu Ile 370 375 380 Glu Glu Ser Tyr Glu Gly Ala
Phe Val Leu Glu Pro Ala Arg Gly Leu 385 390 395 400 His Glu Asn Val
Ala Cys Leu Asp Phe Ala Ser Met Tyr Pro Ser Ile 405 410 415 Met Ile
Asn Phe Asn Ile Ser Pro Asp Thr Leu Val Lys Gly Glu Cys 420 425 430
Glu Asp Cys Tyr Val Ala Pro Glu Val Gly His Lys Phe Arg Lys Ser 435
440 445 Pro Asp Gly Phe Phe Lys Arg Ile Leu Lys Met Leu Ile Glu Lys
Arg 450 455 460 Arg Glu Met Lys Arg Gln Met Lys Glu Leu Asp Pro Asp
Ser Glu Asp 465 470 475 480 Tyr Lys Leu Leu Asp Ile Lys Gln Gln Thr
Leu Lys Val Leu Thr Asn 485 490 495 Ser Phe Tyr Gly Tyr Thr Gly Trp
Asn Leu Ala Arg Trp Tyr Cys Arg 500 505 510 Glu Cys Ala Glu Ala Thr
Thr Ala Trp Gly Arg Tyr Phe Ile Lys Arg 515 520 525 Ala Val Lys Ile
Ala Glu Ser Met Gly Phe Glu Val Leu Tyr Gly Asp 530 535 540 Thr Asp
Ser Leu Phe Ile Lys Lys Asn Lys Leu Asn Leu Lys Asp Leu 545 550 555
560 Glu Lys Glu Cys Leu Lys Leu Ile Asp Val Ile Ser Lys Glu Leu Pro
565 570 575 Ile Gln Leu Glu Ile Asp Glu Phe Tyr Lys Ala Ile Phe Phe
Val Glu 580 585 590 Lys Lys Arg Tyr Ala Gly Leu Thr Asp Asp Asp Arg
Ile Val Val Lys 595 600 605 Gly Leu Glu Val Arg Arg Gly Asp Trp Cys
Glu Leu Ala Lys Arg Val 610 615 620 Gln Arg Glu Val Ile Glu Ile Ile
Leu Arg Glu Arg Asn Pro Asp Lys 625 630 635 640 Ala Leu Lys Phe Val
Lys Asn Val Ile Glu Glu Ile Lys Glu Gly Lys 645 650 655 Phe Lys Leu
Glu Asp Tyr Val Ile Tyr Lys Gly Leu Thr Lys Lys Pro 660 665 670 Asp
Lys Tyr Glu Ser Lys Gln Ala His Val Lys Ala Ala Leu Arg Ala 675 680
685 Met Glu Met Gly Ile Tyr Tyr Pro Ile Gly Thr Lys Val Gly Phe Val
690 695 700 Ile Val Lys Gly Gly Gly Ser Ile Ser Asp Arg Ala Tyr Pro
Ile Glu 705 710 715 720 Leu Ile Glu Glu Phe Asp Gly Glu Asn Leu Lys
Ile Arg Thr Pro Ser 725 730 735 Gly Ile Met Val Lys Lys Ile Asp Lys
Asp Tyr Tyr Ile Asp His Gln 740 745 750 Ile Ile Pro Ala Val Met Arg
Ile Leu Glu Arg Phe Gly Tyr Thr Glu 755 760 765 Ala Ser Leu Lys Thr
Thr Ile Gln Lys Thr Leu Phe Asp Phe Thr 770 775 780
36849PRTCaldicellulosiruptor hydrothermalis 36Met Lys Leu Val Ile
Phe Asp Gly Asn Ser Ile Leu Tyr Arg Ala Phe 1 5 10 15 Phe Ala Leu
Pro Glu Leu Thr Thr Ser Ser Asn Ile Pro Thr Asn Ala 20 25 30 Ile
Tyr Gly Phe Ile Asn Val Ile Leu Lys Tyr Leu Glu Gln Glu Lys 35 40
45 Pro Asp Tyr Ile Ala Val Ala Phe Asp Lys Arg Gly Arg Glu Ala Arg
50 55 60 Lys Ser Glu Tyr Gln Glu Tyr Lys Ala Asn Arg Lys Pro Met
Pro Asp 65 70 75 80 Asn Leu Gln Val Gln Ile Pro Tyr Val Arg Glu Ile
Leu Tyr Ala Leu 85 90 95 Asn Ile Pro Ile Val Glu Phe Glu Gly Tyr
Glu Ala Asp Asp Val Ile 100 105 110 Gly Ser Leu Val Asn Lys Phe Lys
Asn Thr Gly Leu Asp Ile Val Ile 115 120 125 Ile Thr Gly Asp Arg Asp
Thr Leu Gln Leu Leu Asp Lys Asn Val Val 130 135 140 Val Lys Ile Val
Ser Thr Lys Phe Asp Arg Thr Met Glu Asp Leu Tyr 145 150 155 160 Thr
Ile Glu Asn Ile Lys Glu Lys Tyr Gly Val Trp Ala Asn Gln Val 165 170
175 Pro Asp Tyr Lys Ala Leu Val Gly Asp Gln Ser Asp Asn Ile Pro Gly
180 185 190 Val Lys Gly Ile Gly Glu Lys Ser Ala Gln Lys Leu Leu Glu
Glu Tyr 195 200 205 Ser Ser Leu Glu Glu Ile Tyr Gln Asn Leu Asp Lys
Ile Lys Gly Ser 210 215 220 Ile Arg Glu Lys Leu Glu Ala Gly Lys Asp
Met Ala Phe Leu Ser Lys 225 230 235 240 Arg Leu Ala Thr Ile Val Cys
Asp Leu Pro Leu Asn Val Asn Leu Glu 245 250 255 Asp Leu Arg Thr Lys
Glu Trp Asn Lys Glu Arg Leu Tyr Glu Ile Leu 260 265 270 Val Gln Leu
Glu Phe Lys Ser Ile Ile Lys Arg Leu Gly Leu Ser Glu 275 280 285 Asn
Ile Gln Phe Glu Phe Val Gln Gln Arg Thr Asp Ile Pro Asp Val 290 295
300 Glu Gln Arg Glu Leu Glu Ser Ile Ser Arg Ile Arg Ser Lys Glu Ile
305 310 315 320 Pro Leu Met Phe Val Gln Asp Glu Lys Cys Phe Tyr Leu
Tyr Asp Gln 325 330 335 Glu Ser Asn Thr Val Phe Val Thr Arg Asp Arg
His Leu Val Glu Glu 340 345 350 Ile Leu Lys Ser Asp Thr Val Lys Ile
Val Tyr Asp Leu Lys Asn Ile 355 360 365 Phe His Gln Leu Asn Leu Glu
Asp Thr Asp Asn Ile Lys Asn Cys Glu 370 375 380 Asp Val Met Ile Ala
Ser Tyr Val Leu Asp Ser Thr Arg Ser Ser Tyr 385 390 395 400 Glu Leu
Glu Thr Leu Phe Val Ser Tyr Leu Asn Thr Asp Ile Glu Ala 405 410 415
Val Lys Lys Asp Lys Lys Met Val Ser Val Val Leu Leu Lys Arg Leu 420
425 430 Trp Asp Asp Leu Leu Arg Leu Ile Asp Leu Asn Ser Cys Gln Phe
Leu 435 440 445 Tyr Glu Asn Ile Glu Arg Pro Leu Ile Pro Val Leu Tyr
Glu Met Glu 450 455 460 Lys Thr Gly Phe Lys Val Asp Arg Asp Ala Leu
Leu Gln Tyr Thr Lys 465 470 475 480 Glu Ile Glu Asn Lys Ile Leu Lys
Leu Glu Thr Gln Ile Tyr Gln Ile 485 490 495 Ala Gly Glu Trp Phe Asn
Ile Asn Ser Pro Lys Gln Leu Ser Tyr Ile 500 505 510 Leu Phe Glu Lys
Leu Lys Leu Pro Val Ile Lys Lys Thr Lys Thr Gly 515 520 525 Tyr Ser
Thr Asp Ala Glu Val Leu Glu Glu Phe Asp Lys His Glu Ile 530 535 540
Val Pro Leu Ile Leu Asp Tyr Arg Met Tyr Thr Lys Ile Leu Thr Thr 545
550 555 560 Tyr Cys Gln Gly Leu Leu Gln Ala Ile Asn Pro Ser Ser Gly
Arg Val 565 570 575 His Thr Thr Phe Ile Gln Thr Gly Thr Ala Thr Gly
Arg Leu Ala Ser 580 585 590 Ser Asp Pro Asn Leu Gln Asn Ile Pro Val
Lys Tyr Asp Glu Gly Lys 595 600 605 Leu Ile Arg Lys Val Phe Val Pro
Glu Glu Gly His Val Leu Ile Asp 610 615 620 Ala Asp Tyr Ser Gln Ile
Glu Leu Arg Ile Leu Ala His Ile Ser Glu 625 630 635 640 Asp Glu Arg
Leu Ile Asn Ala Phe Lys Asn Asn Ile Asp Ile His Ser 645 650 655 Gln
Thr Ala Ala Glu Val Phe Gly Val Asp Ile Ala Asp Val Thr Pro 660 665
670 Glu Met Arg Ser Gln Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly
675 680 685 Ile Ser Asp Tyr Gly Leu Ala Arg Asp Ile Lys Ile Ser Arg
Lys Glu 690 695 700 Ala Ala Glu Phe Ile Asn Lys Tyr Phe Glu Arg Tyr
Pro Lys Val Lys 705 710 715 720 Glu Tyr Leu Asp Asn Ile Val Arg Phe
Ala Arg Glu Asn Gly Tyr Val 725 730 735 Leu Thr Leu Phe Asn Arg Lys
Arg Tyr Val Lys Asp Ile Lys Ser Ala 740 745 750 Asn Arg Asn Ala Arg
Ser Tyr Ala Glu Arg Ile Ala Met Asn Ser Pro 755 760 765 Ile Gln Gly
Ser Ala Ala Asp Ile Met Lys Leu Ala Met Ile Lys Val 770 775 780 Tyr
Gln Lys Leu Lys Glu Asn Asn Leu Lys Ser Lys Ile Ile Leu Gln 785 790
795 800 Val His Asp Glu Leu Leu Ile Glu Ala Pro Tyr Glu Glu Lys Asp
Ile 805 810 815 Val Lys Arg Ile Val Lys Arg Glu Met Glu Asn Ala Val
Ala Leu Lys 820 825 830 Val Pro Leu Val Val Glu Val Lys Glu Gly Leu
Asn Trp Tyr Glu Thr 835 840 845 Lys 37781PRTDesulfurococcus mucosus
37Met Glu Lys Arg Val Tyr Leu Val Asp Ile Thr Tyr Gly Leu Val Gly 1
5 10 15 Asn Ser Pro Glu Ile Arg Met Phe Gly Val Asp Glu Asn Gly Glu
Lys 20 25 30 Val Val Ile Leu Asp Arg Gly Phe Arg Pro Tyr Phe Tyr
Val Ile Pro 35 40 45 Glu Glu Gly Phe Glu Asp Gln Val Ala Arg Val
Ile Gly Lys Met Gln 50 55 60 Asn Val Ile Lys Ala Asp Val Thr Glu
Arg Arg Leu Phe Gly Lys Pro 65 70 75 80 Ile Lys Val Val Lys Val Thr
Val Thr Val Pro Asp Lys Val Arg Glu 85 90 95 Leu Arg Asp Arg Val
Lys Ser Ile Gln His Val Lys Glu Val Leu Glu 100 105 110 Ala Asp Ile
Arg Phe Tyr Ile Arg Tyr Met Ile Asp Asn Asp Ile Arg 115 120 125 Pro
Gly Trp Leu Met Phe Ser Asn Leu Lys Pro Val Asp Asn Lys Ile 130 135
140 Gly Gly Val Ser Asn Val Tyr Leu Thr Glu Thr Pro Pro Thr Ser Leu
145 150 155 160 Asp Leu Gly Ile Met Pro Arg Leu Asn Tyr Met Ala Leu
Asp Ile Glu 165 170 175 Val Tyr Asn Pro Arg Gly Thr Pro Asp Pro Lys
Arg Asp Pro Ile Ile 180 185 190 Ile Ile Ala Leu Ala Asn Ser Asn Gly
Asp Val Lys Leu Leu Thr Leu 195 200 205 Asp Asn Tyr Lys His Glu Arg
Glu Met Leu Asn Asp Met Met Ser Val 210 215 220 Ile Lys Glu Trp Asp
Pro Asp Val Leu Phe Gly Tyr Asn Ser Asn Lys 225 230 235 240 Phe Asp
Met Pro Tyr Leu Val Asn Arg Ala Asp Ala Leu Asn Val Lys 245 250 255
Leu Gln Leu Ser Lys Tyr Gly Thr Pro Pro Glu Gln Ser Val Tyr Gly 260
265 270 His Trp Ser Ile Ile Gly Arg Ala His Ile Asp Leu Tyr Asn Phe
Ile 275 280 285 Glu Asp Met Thr Asp Val Lys Arg Lys Ser Leu Asp Tyr
Val Ala Glu 290 295 300 Tyr Phe Gly Val Met Lys
Arg Ser Glu Arg Val Asn Ile Pro Gly His 305 310 315 320 Arg Ile Tyr
Gln Tyr Trp Asp Asp Glu Gly Lys Arg Ser Gln Leu Ile 325 330 335 Lys
Tyr Ala Arg Asp Asp Val Leu Ser Thr Leu Gly Leu Gly Lys Ile 340 345
350 Leu Leu Pro Tyr Ala Met Gln Leu Ala Ser Val Ser Gly Leu Pro Leu
355 360 365 Asp Gln Val Gly Pro Ala Ser Val Gly Ser Arg Val Glu Met
Met Ile 370 375 380 Met His Glu Ala Tyr Lys Met Gly Glu Leu Ala Pro
Asn Arg Val Glu 385 390 395 400 Arg Pro Tyr Glu Thr Tyr Lys Gly Ala
Ile Val Leu Glu Pro Lys Pro 405 410 415 Gly Ile His Tyr Asn Ile Ala
Val Leu Asp Phe Ser Ser Met Tyr Pro 420 425 430 Asn Ile Met Leu Lys
Tyr Asn Ile Ser Pro Asp Thr Leu Val Leu Asp 435 440 445 Ser Ser Glu
Gly Asp Tyr Tyr Thr Ala Pro Glu Val Gly Tyr Arg Phe 450 455 460 Arg
Lys Ser Pro Arg Gly Leu Tyr Ala Ser Leu Leu Gln Lys Leu Ile 465 470
475 480 Glu Ala Arg Arg Glu Ala Arg Asp Glu Met Arg Asn Tyr Pro Glu
Gly 485 490 495 Ser Phe Glu Trp Val Leu Leu Asn Glu Arg Gln Arg Ala
Leu Lys Ile 500 505 510 Met Ala Asn Ala Met Tyr Gly Tyr Cys Gly Trp
Leu Gly Ala Arg Trp 515 520 525 Tyr Ile Arg Glu Val Ala Glu Ser Val
Thr Ala Trp Gly Arg Tyr Leu 530 535 540 Leu Lys Thr Ala Met Ser Met
Ala Lys Glu Arg Gly Leu Thr Val Ile 545 550 555 560 Tyr Gly Asp Thr
Asp Ser Leu Phe Val Thr Tyr Asp Lys Asp Lys Val 565 570 575 Ala Asp
Ile Ile Ser Arg Ile Asn Glu Met Gly Phe Glu Val Lys Ile 580 585 590
Asp Lys Val Tyr Ser Lys Leu Ile Phe Thr Glu Ser Lys Lys Arg Tyr 595
600 605 Ile Gly Leu Thr Ala Asp Gly Glu Val Asp Ile Val Gly Phe Glu
Ala 610 615 620 Val Arg Gly Asp Trp Ser Glu Leu Ala Arg Asn Val Gln
Glu Arg Val 625 630 635 640 Ala Glu Leu Val Leu Arg Glu Ser Val Asp
Glu Ala Val Lys Tyr Val 645 650 655 Lys Ser Val Ile Asp Asp Leu Arg
Asn Tyr Arg Phe Thr Ile Asp Asp 660 665 670 Val Ile Ile Trp Lys Thr
Leu Asp Lys Asp Ile Asn Glu Tyr Lys Ala 675 680 685 Ile Gln Pro His
Val Val Ala Ala Arg Arg Leu Met Glu Lys Gly Tyr 690 695 700 Val Val
Asn Lys Gly Asp Thr Val Gly Phe Val Ile Val Lys Asp Ser 705 710 715
720 Gly Asp Lys Leu Thr Gln Arg Ala Tyr Pro Tyr Val Phe Ile Asn Asp
725 730 735 Val Lys Glu Ile Asp Val Asp Tyr Tyr Val Glu Lys Gln Val
Ile Pro 740 745 750 Ala Ala Leu Arg Ile Leu Glu Val Phe Gly Val Asn
Glu Ala Ala Leu 755 760 765 Leu Gly Lys Thr Gly Lys Ser Ile Leu Asp
Tyr Phe His 770 775 780 38803PRTPyrolobus fumarii 38Met Thr Glu Val
Val Phe Thr Val Leu Asp Ser Ser Tyr Glu Val Val 1 5 10 15 Gly Lys
Glu Pro Gln Val Ile Ile Trp Gly Ile Ala Glu Asn Gly Glu 20 25 30
Arg Val Val Leu Ile Asp Arg Ser Phe Arg Pro Tyr Phe Tyr Ala Leu 35
40 45 Leu Ala Pro Gly Ala Asp Pro Lys Gln Val Ala Gln Arg Ile Arg
Ala 50 55 60 Leu Ser Arg Pro Lys Ser Pro Ile Ile Gly Val Glu Asp
Asp Lys Arg 65 70 75 80 Lys Tyr Phe Gly Arg Pro Arg Arg Val Leu Arg
Ile Arg Thr Val Leu 85 90 95 Pro Glu Ala Val Arg Glu Tyr Arg Glu
Leu Val Lys Asn Val Asp Gly 100 105 110 Val Glu Asp Val Leu Glu Ala
Asp Ile Arg Phe Ala Met Arg Tyr Leu 115 120 125 Ile Asp His Asp Leu
Phe Pro Phe Thr Trp Tyr Arg Val Glu Ala Glu 130 135 140 Pro Leu Glu
Asn Lys Met Gly Phe Arg Val Asp Lys Val Tyr Leu Val 145 150 155 160
Lys Ser Arg Pro Glu Pro Leu Tyr Gly Glu Ala Leu Ala Pro Thr Lys 165
170 175 Leu Pro Asp Leu Arg Ile Leu Ala Phe Asp Ile Glu Val Tyr Ser
Lys 180 185 190 Gln Gly Ser Pro Arg Pro Glu Arg Asp Pro Val Ile Val
Ile Ala Val 195 200 205 Lys Thr Asp Asp Gly Asp Glu Val Leu Phe Ile
Ala Glu Gly Lys Asp 210 215 220 Asp Arg Lys Pro Ile Arg Glu Phe Val
Glu Tyr Val Lys Arg Tyr Asp 225 230 235 240 Pro Asp Ile Ile Val Gly
Tyr Asn Asn Asn His Phe Asp Trp Pro Tyr 245 250 255 Leu Leu Arg Arg
Ala Arg Ile Leu Gly Ile Lys Leu Asp Val Thr Arg 260 265 270 Arg Val
Gly Ala Glu Pro Thr Thr Ser Val His Gly His Val Ser Val 275 280 285
Pro Gly Arg Leu Asn Val Asp Leu Tyr Asp Tyr Ala Glu Glu Met Pro 290
295 300 Glu Ile Lys Ile Lys Ser Leu Glu Glu Val Ala Glu Tyr Leu Gly
Val 305 310 315 320 Met Lys Lys Ser Glu Arg Val Ile Ile Asn Trp Trp
Glu Ile Pro Asp 325 330 335 Tyr Trp Asp Asp Pro Lys Lys Arg Pro Leu
Leu Leu Gln Tyr Ala Arg 340 345 350 Asp Asp Val Arg Ala Thr Tyr Gly
Leu Ala Glu Lys Ile Leu Pro Phe 355 360 365 Ala Ile Gln Leu Ser Tyr
Val Thr Gly Leu Pro Leu Asp Gln Val Gly 370 375 380 Ala Met Ser Val
Gly Phe Arg Leu Glu Trp Tyr Leu Ile Arg Ala Ala 385 390 395 400 Phe
Lys Met Lys Glu Leu Val Pro Asn Arg Val Glu Arg Pro Glu Glu 405 410
415 Thr Tyr Arg Gly Ala Ile Val Leu Glu Pro Leu Arg Gly Val His Glu
420 425 430 Asn Ile Ala Val Leu Asp Phe Ser Ser Met Tyr Pro Asn Ile
Met Ile 435 440 445 Lys Tyr Asn Val Gly Pro Asp Thr Leu Val Arg Pro
Gly Glu Glu Cys 450 455 460 Gly Glu Cys Gly Cys Trp Glu Ala Pro Glu
Val Lys His Arg Phe Arg 465 470 475 480 Arg Cys Pro Pro Gly Phe Phe
Lys Thr Val Leu Glu Arg Leu Leu Glu 485 490 495 Leu Arg Lys Arg Val
Arg Ala Glu Met Lys Lys Tyr Pro Pro Asp Ser 500 505 510 Pro Glu Tyr
Arg Leu Leu Asp Glu Arg Gln Lys Ala Leu Lys Val Leu 515 520 525 Ala
Asn Ala Ser Tyr Gly Tyr Met Gly Trp Ser Gly Ala Arg Trp Tyr 530 535
540 Cys Arg Glu Cys Ala Glu Ala Val Thr Ala Trp Gly Arg His Leu Ile
545 550 555 560 Arg Thr Ala Ile Asn Ile Ala Arg Lys Leu Gly Leu Lys
Val Ile Tyr 565 570 575 Gly Asp Thr Asp Ser Leu Phe Val Thr Tyr Asp
Pro Glu Lys Val Glu 580 585 590 Lys Phe Ile Lys Ile Ile Glu Glu Glu
Leu Gly Phe Glu Ile Lys Leu 595 600 605 Glu Lys Val Tyr Lys Arg Val
Phe Phe Thr Glu Ala Lys Lys Arg Tyr 610 615 620 Ala Gly Leu Leu Glu
Asp Gly Arg Ile Asp Ile Val Gly Phe Glu Ala 625 630 635 640 Val Arg
Gly Asp Trp Cys Glu Leu Ala Lys Glu Val Gln Thr Lys Val 645 650 655
Val Glu Ile Val Leu Lys Thr Ser Asp Val Asn Lys Ala Val Glu Tyr 660
665 670 Val Arg Lys Ile Val Lys Glu Leu Glu Glu Gly Lys Val Pro Ile
Glu 675 680 685 Lys Leu Val Ile Trp Lys Thr Leu Ser Lys Arg Leu Glu
Glu Tyr Thr 690 695 700 Thr Glu Ala Pro His Val Val Ala Ala Lys Arg
Met Leu Ser Ala Gly 705 710 715 720 Tyr Arg Val Ser Pro Gly Asp Lys
Ile Gly Tyr Val Ile Val Lys Gly 725 730 735 Gly Gly Arg Ile Ser Gln
Arg Ala Trp Pro Tyr Phe Met Val Lys Asp 740 745 750 Pro Ser Gln Ile
Asp Val Thr Tyr Tyr Val Asp His Gln Ile Ile Pro 755 760 765 Ala Ala
Leu Arg Ile Leu Gly Tyr Phe Gly Ile Thr Glu Lys Lys Leu 770 775 780
Lys Ala Ser Ala Thr Gly Gln Lys Thr Leu Phe Asp Phe Leu Ala Lys 785
790 795 800 Lys Ser Lys 39786PRTPyrobaculum oguniense 39Met Glu Ile
Arg Val Trp Pro Leu Asp Val Thr Tyr Ile Val Val Gly 1 5 10 15 Gly
Val Pro Glu Val Arg Val Phe Gly Ile Ala Glu Gly Gly Glu Arg 20 25
30 Val Val Leu Ala Asp Arg Ser Phe Arg Pro Tyr Phe Tyr Val Asp Cys
35 40 45 Ala Gly Cys Asp Pro His Ala Val Lys Thr His Leu Gly Arg
Thr Ala 50 55 60 Pro Val Glu Gly Val Glu Leu Val Glu Arg Arg Phe
Leu Gly Arg Pro 65 70 75 80 Arg Gln Phe Leu Lys Val Val Ala Lys Ile
Pro Glu Asp Val Arg Arg 85 90 95 Leu Arg Glu Ala Ala Ser Thr Ile
Pro Gly Val Arg Gly Val Tyr Glu 100 105 110 Ala Asp Ile Arg Phe Tyr
Met Arg Tyr Val Ile Asp Met Gly Val Val 115 120 125 Pro Cys Ser Trp
Asn Val Ala Glu Val Glu Val Ala Asp Glu Lys Leu 130 135 140 Gly Ser
Leu Pro Val Tyr Arg Val Val Lys Trp Gly Gly Ala Val Glu 145 150 155
160 Gly Phe Pro Pro Pro Leu Arg Val Leu Ala Phe Asp Ile Glu Val Tyr
165 170 175 Asn Glu Arg Gly Thr Pro Asp Pro Ala Arg Asp Pro Ile Val
Met Ile 180 185 190 Ala Val Gln Ser Ser Asp Gly Arg Leu Glu Val Phe
Glu Ala Ser Gly 195 200 205 Arg Asp Asp Arg Gly Val Leu Arg Ser Phe
Val Glu Tyr Val Arg Ser 210 215 220 Phe Asp Pro Asp Val Val Val Gly
Tyr Asn Ser Asn Asn Phe Asp Trp 225 230 235 240 Pro Tyr Leu Ala Glu
Arg Ala Lys Ala Val Gly Val Pro Leu Arg Val 245 250 255 Asp Arg Leu
Gly Gly Ala Pro Gln Gln Ser Val Tyr Gly His Trp Ser 260 265 270 Val
Leu Gly Arg Ala Asn Val Asp Leu Tyr Asn Ile Val Asp Glu Phe 275 280
285 Pro Glu Ile Lys Leu Lys Thr Leu Asp Arg Val Ala Glu Tyr Phe Gly
290 295 300 Val Met Arg Arg Asp Glu Arg Val Leu Ile Pro Gly His Lys
Ile Tyr 305 310 315 320 Glu Tyr Trp Arg Asp Pro Ser Lys Arg Pro Leu
Leu Arg Gln Tyr Val 325 330 335 Ile Asp Asp Val Arg Ser Thr Tyr Gly
Leu Ala Glu Arg Leu Leu Pro 340 345 350 Phe Leu Ile Gln Leu Ser Ser
Val Ser Gly Leu Pro Leu Asp Gln Val 355 360 365 Ala Ala Ala Ser Val
Gly Asn Arg Val Glu Trp Met Leu Leu Arg Tyr 370 375 380 Ala Tyr Gly
Leu Gly Glu Val Ala Pro Asn Arg Glu Glu Arg Glu Tyr 385 390 395 400
Glu Pro Tyr Lys Gly Ala Ile Val Leu Glu Pro Lys Pro Gly Leu Tyr 405
410 415 Ser Asp Val Leu Val Leu Asp Phe Ser Ser Met Tyr Pro Asn Val
Met 420 425 430 Met Arg Tyr Asn Leu Ser Pro Asp Thr Tyr Leu Glu Pro
Gly Glu Pro 435 440 445 Asp Pro Pro Glu Gly Val Tyr Val Ala Pro Glu
Val Gly His Arg Phe 450 455 460 Arg Lys Glu Pro Pro Gly Phe Ile Pro
Gln Val Leu Arg Arg Leu Val 465 470 475 480 Ala Leu Arg Arg Ala Val
Arg Glu Glu Met Lys Lys Tyr Gln Pro Asp 485 490 495 Thr Pro Glu Tyr
Arg Val Leu Asp Glu Arg Gln Lys Ala Leu Lys Ile 500 505 510 Met Ala
Asn Ala Met Tyr Gly Tyr Thr Gly Trp Val Gly Ala Arg Trp 515 520 525
Tyr Lys Lys Glu Val Ala Glu Ser Val Thr Ala Phe Ala Arg Ala Ile 530
535 540 Leu Lys Asp Val Ile Asp Tyr Ala Arg Arg Leu Gly Ile Val Val
Ile 545 550 555 560 Tyr Gly Asp Thr Asp Ser Leu Phe Val Lys Lys Gly
Gly Asp Leu Glu 565 570 575 Lys Leu Ala Arg Tyr Val Asp Glu Lys Tyr
Gly Ile Glu Ile Lys Val 580 585 590 Asp Lys Asp Tyr Glu Lys Val Leu
Phe Thr Glu Ala Lys Lys Arg Tyr 595 600 605 Ala Gly Leu Leu Arg Asp
Gly Arg Ile Asp Ile Val Gly Phe Glu Val 610 615 620 Val Arg Gly Asp
Trp Ser Glu Leu Ala Lys Glu Val Gln Leu Lys Val 625 630 635 640 Ile
Glu Leu Ile Leu Lys Ala Arg Asp Leu Ser Glu Ala Arg Gln Arg 645 650
655 Val Ile Lys Tyr Val Lys Asp Val Ile Glu Arg Leu Lys Ser Gly Lys
660 665 670 Phe Asp Leu Asp Asp Leu Ile Ile Trp Lys Thr Leu Asp Lys
Asp Leu 675 680 685 Gly Glu Tyr Lys Ala Tyr Pro Pro His Val Arg Ala
Ala Leu Ile Leu 690 695 700 Lys Lys Lys Gly Tyr Lys Val Gly Arg Gly
Thr Thr Ile Gly Tyr Val 705 710 715 720 Val Val Lys Gly Gly Glu Lys
Val Ser Glu Arg Ser Leu Pro Tyr Ile 725 730 735 Leu Val Asp Asp Leu
Ala Lys Ile Asp Val Asp Tyr Tyr Ile Glu Lys 740 745 750 Gln Val Ile
Pro Ala Ala Leu Arg Ile Ala Glu Val Ile Gly Val Lys 755 760 765 Glu
Gly Asp Leu Arg Ala Gly Arg Ser Glu Lys Ser Leu Leu Asp Phe 770 775
780 Phe Glu 785 40801PRTStaphylothermus marinus 40Met Ser Glu Lys
Ile Asn Leu Glu Phe Tyr Phe Leu Asp Asn Ser Tyr 1 5 10 15 Glu Val
Ile Gly Asn Glu Pro His Ile Ile Ile Trp Gly Ile Thr Arg 20 25 30
Asp Gly Arg Arg Val Leu Leu Arg Asp Arg Arg Phe Arg Pro Tyr Phe 35
40 45 Tyr Ala Ile Leu Lys Asp Lys Val Asn Ile Glu Asp Leu Ala Arg
Lys 50 55 60 Ile Arg Thr Tyr Ser Asp Pro Lys Ser Pro Ile Ile Gly
Val Glu Pro 65 70 75 80 Val Glu Lys Lys Tyr Phe Gly Arg Lys Val Ser
Ala Leu Lys Ile Ile 85 90 95 Thr Met Ile Pro Glu Tyr Val Arg Lys
Tyr Arg Glu Lys Ile Lys Ser 100 105 110 Leu Pro Glu Val Leu Glu Val
Val Glu Ala Asp Ile Arg Phe Ser Ile 115 120 125 Arg Tyr Ile Ile Asp
His Asp Leu Arg Pro Cys Gly Trp His Val Ala 130 135 140 Glu Val Val
Glu Val Pro Lys Lys Pro Ile Tyr Arg Val Asp Ala Glu 145 150 155 160
Tyr Glu Ile Ile Gly Asp Ile Lys Pro Leu Glu Gln Thr Leu Gln Pro 165
170 175 Asp Leu Arg Ile Ile Ala Phe Asp Ile Glu Val Tyr Asn Lys Ser
Gly 180 185 190 Thr Pro Arg Pro Gln Thr Asp Pro Ile Ile Ile Ile Gly
Ile Met Asn 195 200 205 Asn Asn Gly Asp Ile Lys Gln Phe Leu Ala Asn
Lys Tyr Asp Asp Lys 210 215 220 Ile Ser Val Glu Glu Phe Val Asn Tyr
Val Lys Thr Phe Asp Pro Asp 225 230
235 240 Ile Ile Val Gly Tyr Asn Thr Asp Gly Phe Asp Trp Pro Tyr Leu
Ile 245 250 255 Glu Arg Ser Lys Tyr Ile Gly Val Lys Leu Asp Val Thr
Arg Arg Val 260 265 270 Gly Ala Thr Pro Arg Thr Ser Thr Tyr Gly His
Ile Ser Val Pro Gly 275 280 285 Arg Leu Asn Thr Asp Leu Tyr His Phe
Ala Glu Glu Ile Pro Glu Val 290 295 300 Lys Val Lys Ser Leu Glu Asn
Val Ala Glu Tyr Leu Gly Val Met Lys 305 310 315 320 Lys Ser Glu Arg
Val Ile Ile Glu Tyr Ile Asp Ile Pro Lys Tyr Trp 325 330 335 Asp Asp
Glu Lys Leu Arg Pro Lys Leu Leu Gln Tyr Asn Ile Asp Asp 340 345 350
Val Lys Ser Thr Tyr Gly Leu Ala Glu Lys Phe Leu Pro Phe Ala Met 355
360 365 Gln Leu Ser Asn Ile Thr Gly Leu Pro Leu Asp Gln Val Gly Ala
Ala 370 375 380 Ser Val Gly Phe Arg Leu Glu Trp Tyr Leu Met Arg Glu
Ala Phe Arg 385 390 395 400 Tyr Gly Glu Leu Val Pro Asn Arg Val Glu
Arg Ala Ala Glu Ser Tyr 405 410 415 Arg Gly Ala Val Val Leu Lys Pro
Val Lys Gly Val His Glu Asn Ile 420 425 430 Ala Val Leu Asp Phe Ser
Ser Met Tyr Pro Asn Ile Met Ile Lys Tyr 435 440 445 Asn Val Gly Pro
Asp Thr Ile Val Arg Asn Glu Lys Cys Asn Pro Asp 450 455 460 Lys His
Asn Ile Ala Pro Glu Val Gly His Cys Phe Arg Lys Glu Pro 465 470 475
480 Pro Gly Phe Phe Lys Arg Val Leu Glu Thr Leu Leu Arg Leu Arg Lys
485 490 495 Gln Ile Lys Ser Glu Met Lys Lys Tyr Pro Pro Thr Ser Tyr
Glu Tyr 500 505 510 Arg Leu Leu Asp Glu Arg Gln Lys Ala Val Lys Val
Leu Ala Asn Ala 515 520 525 Thr Tyr Gly Tyr Met Gly Trp Ile His Ala
Arg Trp Tyr Cys Arg Glu 530 535 540 Cys Ala Glu Ala Val Thr Ala Trp
Gly Arg Gln Thr Ile Lys Ser Ala 545 550 555 560 Ile Glu Leu Ala Arg
Lys Leu Gly Leu Lys Val Ile Tyr Gly Asp Thr 565 570 575 Asp Ser Leu
Phe Val Thr Tyr Asp Lys Asp Lys Val Glu Lys Leu Ile 580 585 590 Glu
Leu Ile Gln Thr Lys Leu Gly Phe Glu Ile Lys Ile Asp Lys Ile 595 600
605 Tyr Lys Arg Val Phe Phe Thr Glu Ala Lys Lys Arg Tyr Ala Gly Leu
610 615 620 Leu Glu Asp Gly Arg Ile Asp Ile Val Gly Phe Glu Ala Val
Arg Gly 625 630 635 640 Asp Trp Ala Glu Ile Ala Lys Glu Val Gln Glu
Lys Val Thr Glu Ile 645 650 655 Leu Leu Lys Glu Asn Ser Ile Asp Lys
Ala Ile Glu Tyr Val Arg Gln 660 665 670 Val Ile Ala Asp Leu Lys Ala
Gly Lys Ile Pro Leu Asp Lys Leu Ile 675 680 685 Ile Trp Lys Thr Leu
Ser Lys Arg Ile Glu Glu Tyr Ser Val Asp Ala 690 695 700 Pro His Val
Val Ala Ala Lys Lys Leu Ile Lys Ala Gly Ile Lys Val 705 710 715 720
Ser Thr Asn Asp Lys Ile Gly Tyr Val Ile Leu Lys Gly Gly Gly Lys 725
730 735 Ile Ser Ser Arg Ala Glu Pro Tyr Ile Phe Val Lys Asp Pro Lys
Leu 740 745 750 Ile Asp Thr Glu Tyr Tyr Val Asp His Gln Ile Val Pro
Ala Ala Leu 755 760 765 Arg Ile Leu Asn Tyr Phe Gly Val Thr Glu Thr
Gln Leu Lys Arg Ala 770 775 780 Ala Ala Ser Ala Gly Gln Lys Ser Leu
Phe Asp Phe Phe Gly Gly Lys 785 790 795 800 Lys 41776PRTPyrococcus
yayaosii 41Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asn Gly Lys Pro
Val Val 1 5 10 15 Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val
Glu Tyr Asp Arg 20 25 30 Ser Phe Arg Pro Tyr Ile Tyr Ala Leu Leu
Arg Asp Asp Ser Ala Ile 35 40 45 Glu Asp Ile Lys Lys Ile Thr Ala
Glu Arg His Gly Lys Val Val Arg 50 55 60 Val Val Glu Ala Glu Lys
Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 65 70 75 80 Glu Val Trp Lys
Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 85 90 95 Arg Glu
Lys Ile Arg Glu His Pro Ala Val Ile Asp Ile Phe Glu Tyr 100 105 110
Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 115
120 125 Met Glu Gly Asn Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu
Thr 130 135 140 Leu Tyr His Glu Gly Asp Glu Phe Gly Ser Gly Pro Ile
Ile Met Ile 145 150 155 160 Ser Tyr Ala Asp Glu Lys Gly Ala Lys Val
Ile Thr Trp Lys Gly Val 165 170 175 Asp Leu Pro Tyr Val Glu Val Val
Ser Ser Glu Arg Glu Met Ile Lys 180 185 190 Arg Phe Leu Arg Val Ile
Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 195 200 205 Tyr Asn Gly Asp
Asn Phe Asp Phe Pro Tyr Leu Leu Lys Arg Ala Glu 210 215 220 Lys Leu
Gly Met Lys Leu Pro Ile Gly Arg Asp Gly Ser Glu Pro Lys 225 230 235
240 Met Gln Arg Met Gly Asp Gly Phe Ala Val Glu Val Lys Gly Arg Ile
245 250 255 His Phe Asp Ile Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu
Pro Thr 260 265 270 Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly
Arg Pro Lys Glu 275 280 285 Lys Val Tyr Pro Asn Glu Ile Ala Arg Ala
Trp Glu Asn Cys Lys Gly 290 295 300 Leu Glu Arg Val Ala Lys Tyr Ser
Met Glu Asp Ala Lys Val Thr Tyr 305 310 315 320 Glu Leu Gly Arg Glu
Phe Phe Pro Met Glu Ala Gln Leu Ala Arg Leu 325 330 335 Val Gly Gln
Pro Val Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 340 345 350 Val
Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 355 360
365 Pro Asn Arg Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser
370 375 380 Tyr Glu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp
Glu Gly 385 390 395 400 Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro
Ser Ile Ile Ile Thr 405 410 415 His Asn Ile Ser Pro Asp Thr Leu Asn
Lys Glu Gly Cys Asn Ser Tyr 420 425 430 Asp Val Ala Pro Lys Val Gly
His Arg Phe Cys Lys Asp Phe Pro Gly 435 440 445 Phe Ile Pro Ser Leu
Leu Gly Gln Leu Leu Asp Glu Arg Gln Lys Ile 450 455 460 Lys Arg Lys
Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu 465 470 475 480
Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 485
490 495 Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala
Glu 500 505 510 Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Leu Val
Ser Arg Glu 515 520 525 Leu Glu Lys Arg Gly Phe Lys Val Leu Tyr Ile
Asp Thr Asp Gly Leu 530 535 540 Tyr Ala Thr Ile Pro Gly Ser Arg Glu
Trp Asp Lys Ile Lys Glu Arg 545 550 555 560 Ala Leu Glu Phe Val Lys
Tyr Ile Asn Ala Arg Leu Pro Gly Leu Leu 565 570 575 Glu Leu Glu Tyr
Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 580 585 590 Lys Lys
Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 595 600 605
Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 610
615 620 Ala Arg Val Leu Glu Ala Ile Leu Lys Glu Gly Asn Leu Glu Lys
Ala 625 630 635 640 Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser
Lys Tyr Glu Val 645 650 655 Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln
Ile Thr Arg Asp Leu Lys 660 665 670 Asp Tyr Lys Ala Val Gly Pro His
Val Ala Val Ala Lys Arg Leu Ala 675 680 685 Ala Arg Gly Ile Lys Val
Arg Pro Gly Met Val Ile Gly Tyr Leu Val 690 695 700 Leu Arg Gly Asp
Gly Pro Ile Ser Arg Arg Ala Ile Pro Ala Glu Glu 705 710 715 720 Phe
Asp Pro Ser Arg His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 725 730
735 Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg
740 745 750 Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Ala Gly Leu
Asp Ala 755 760 765 Trp Leu Lys Arg Lys Ala Ser Leu 770 775
42773PRTThermococcus sp.AM4-del 42Met Ile Leu Asp Thr Asp Tyr Ile
Thr Glu Asn Gly Lys Pro Val Ile 1 5 10 15 Arg Val Phe Lys Lys Glu
Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 20 25 30 Thr Phe Glu Pro
Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 35 40 45 Glu Asp
Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Arg 50 55 60
Val Lys Arg Ala Glu Lys Val Gln Arg Lys Phe Leu Gly Arg Pro Ile 65
70 75 80 Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro
Ala Ile 85 90 95 Arg Asp Lys Ile Arg Ala His Pro Ala Val Ile Asp
Ile Tyr Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile
Asp Lys Gly Leu Ile Pro 115 120 125 Met Glu Gly Asp Glu Glu Leu Thr
Met Leu Ala Phe Asp Ile Glu Thr 130 135 140 Leu Tyr His Glu Gly Glu
Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 145 150 155 160 Ser Tyr Ala
Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 165 170 175 Asp
Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 180 185
190 Arg Phe Leu Arg Ile Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
195 200 205 Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg
Cys Glu 210 215 220 Lys Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly
Ser Glu Pro Lys 225 230 235 240 Ile Gln Arg Met Gly Asp Arg Phe Ala
Val Glu Val Lys Gly Arg Ile 245 250 255 His Phe Asp Leu Tyr Pro Val
Ile Arg Arg Thr Ile Asn Leu Pro Thr 260 265 270 Tyr Thr Leu Glu Ala
Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 275 280 285 Lys Val Tyr
Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 290 295 300 Leu
Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 305 310
315 320 Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg
Leu 325 330 335 Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr
Gly Asn Leu 340 345 350 Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu
Arg Asn Glu Leu Ala 355 360 365 Pro Asn Lys Pro Asp Glu Lys Glu Leu
Ala Arg Arg Arg Gly Gly Tyr 370 375 380 Ala Gly Gly Tyr Val Lys Glu
Pro Glu Arg Gly Leu Trp Asp Asn Ile 385 390 395 400 Val Tyr Leu Asp
Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 405 410 415 Asn Val
Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 420 425 430
Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 435
440 445 Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile
Lys 450 455 460 Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys
Leu Leu Asp 465 470 475 480 Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala
Asn Ser Tyr Tyr Gly Tyr 485 490 495 Tyr Gly Tyr Ala Lys Ala Arg Trp
Tyr Cys Arg Glu Cys Ala Glu Ser 500 505 510 Val Thr Ala Trp Gly Arg
Glu Tyr Ile Glu Thr Thr Ile Arg Glu Ile 515 520 525 Glu Glu Lys Phe
Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 530 535 540 Phe Ala
Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 545 550 555
560 Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu
565 570 575 Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr
Lys Lys 580 585 590 Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr
Thr Arg Gly Leu 595 600 605 Glu Ile Val Arg Arg Asp Trp Ser Glu Ile
Ala Lys Glu Thr Gln Ala 610 615 620 Arg Val Leu Glu Ala Ile Leu Lys
His Gly Asp Val Glu Glu Ala Val 625 630 635 640 Arg Ile Val Lys Glu
Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 645 650 655 Pro Glu Lys
Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 660 665 670 Tyr
Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 675 680
685 Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu
690 695 700 Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp
Glu Phe 705 710 715 720 Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr
Tyr Ile Glu Asn Gln 725 730 735 Val Leu Pro Ala Val Glu Arg Ile Leu
Lys Ala Phe Gly Tyr Arg Lys 740 745 750 Glu Asp Leu Arg Tyr Gln Lys
Thr Lys Gln Val Gly Leu Gly Ala Trp 755 760 765 Leu Lys Val Lys Lys
770 43775PRTThermococcus hydrothermalis 43Met Ile Leu Asp Thr Asp
Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 1 5 10 15 Arg Ile Phe Lys
Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 20 25 30 Glu Phe
Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 35 40 45
Glu Glu Val Lys Lys Ile Thr Ala Gly Arg His Gly Arg Val Val Lys 50
55 60 Val Lys Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro
Ile 65 70 75 80 Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val
Pro Ala Ile 85 90 95 Arg Asp Glu Ile Arg Arg His Ser Ala Val Val
Asp Ile Tyr Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg Tyr Leu
Ile Asp Lys Gly Leu Ile Pro 115 120 125 Met Glu Gly Asp Glu Glu Leu
Lys Met Met Ser Phe Asp Ile Glu Thr 130 135 140 Leu Tyr His Glu Gly
Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 145 150 155 160 Ser Tyr
Ala Asp Glu Gly Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 165 170 175
Asp Leu Pro
Tyr Val Glu Val Val Ser Thr Glu Lys Glu Met Ile Lys 180 185 190 Arg
Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 195 200
205 Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu
210 215 220 Lys Ile Gly Ile Lys Phe Thr Leu Arg Arg Asp Gly Ser Glu
Pro Lys 225 230 235 240 Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu
Val Lys Gly Arg Ile 245 250 255 His Phe Asp Leu Tyr Pro Val Ile Arg
Arg Thr Ile Asn Leu Pro Thr 260 265 270 Tyr Thr Leu Glu Ala Val Tyr
Glu Ala Val Phe Gly Thr Pro Lys Glu 275 280 285 Lys Val Tyr Pro Glu
Glu Ile Thr Thr Ala Trp Glu Thr Gly Glu Gly 290 295 300 Leu Glu Arg
Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 305 310 315 320
Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 325
330 335 Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn
Leu 340 345 350 Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn
Glu Ile Ala 355 360 365 Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg
Arg Arg Gly Gly Tyr 370 375 380 Ala Gly Gly Tyr Val Lys Glu Pro Glu
Arg Gly Leu Trp Asp Asn Ile 385 390 395 400 Val Tyr Leu Asp Phe Met
Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 405 410 415 Asn Val Ser Pro
Asp Thr Phe Asn Arg Glu Gly Cys Lys Glu Tyr Asp 420 425 430 Thr Ala
Pro Gln Val Gly His Lys Phe Cys Lys Asp Val Gln Gly Phe 435 440 445
Ile Pro Ser Leu Leu Gly Ala Leu Leu Asp Glu Arg Gln Lys Ile Lys 450
455 460 Lys Arg Met Lys Ala Ser Ile Asp Pro Leu Glu Lys Lys Leu Leu
Asp 465 470 475 480 Tyr Arg Gln Lys Ala Ile Lys Ile Leu Ala Asn Ser
Tyr Tyr Gly Tyr 485 490 495 Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys
Lys Glu Cys Ala Glu Ser 500 505 510 Val Thr Ala Trp Gly Arg Asp Tyr
Ile Glu Thr Thr Ile His Glu Ile 515 520 525 Glu Glu Arg Phe Gly Phe
Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 530 535 540 Phe Ala Thr Ile
Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 545 550 555 560 Lys
Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 565 570
575 Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys
580 585 590 Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg
Gly Leu 595 600 605 Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys
Glu Thr Gln Ala 610 615 620 Arg Val Leu Glu Ala Ile Leu Arg His Gly
Asp Val Glu Glu Ala Val 625 630 635 640 Arg Ile Val Lys Asp Val Thr
Glu Lys Leu Ser Lys Tyr Glu Val Pro 645 650 655 Pro Glu Lys Leu Val
Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp 660 665 670 Tyr Lys Ala
Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala 675 680 685 Arg
Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 690 695
700 Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe
705 710 715 720 Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile
Glu Asn Gln 725 730 735 Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala
Phe Gly Tyr Lys Lys 740 745 750 Glu Glu Leu Arg Tyr Gln Lys Thr Arg
Gln Val Gly Leu Gly Ala Trp 755 760 765 Leu Lys Leu Lys Gly Lys Lys
770 775 44774PRTThermococcus thioreducens 44Met Ile Leu Asp Ala Asp
Tyr Ile Thr Glu Asp Gly Lys Pro Val Val 1 5 10 15 Arg Ile Phe Lys
Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 20 25 30 Glu Phe
Glu Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Ala Ile 35 40 45
Glu Glu Ile Lys Lys Ile Thr Ala Asp Arg His Gly Lys Val Val Lys 50
55 60 Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro
Ile 65 70 75 80 Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val
Pro Ala Ile 85 90 95 Arg Asp Glu Ile Arg Lys His Pro Ala Val Val
Asp Ile Tyr Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg Tyr Leu
Ile Asp Lys Gly Leu Ile Pro 115 120 125 Met Glu Gly Asp Glu Glu Leu
Lys Met Leu Ala Phe Asp Ile Glu Thr 130 135 140 Leu Tyr His Glu Gly
Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 145 150 155 160 Ser Tyr
Ala Asp Glu Asp Gly Ala Arg Val Ile Thr Trp Lys Lys Ile 165 170 175
Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 180
185 190 Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile
Thr 195 200 205 Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys
Arg Cys Glu 210 215 220 Lys Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp
Gly Ser Glu Pro Lys 225 230 235 240 Ile Gln Arg Met Gly Asp Arg Phe
Ala Val Glu Val Lys Gly Arg Ile 245 250 255 His Phe Asp Leu Tyr Pro
Leu Ile Arg Arg Thr Ile Asn Leu Pro Thr 260 265 270 Tyr Thr Leu Glu
Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 275 280 285 Lys Val
Tyr Ala Glu Glu Ile Ala Leu Ala Trp Glu Ser Gly Glu Gly 290 295 300
Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Phe 305
310 315 320 Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser
Arg Leu 325 330 335 Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser
Thr Gly Asn Leu 340 345 350 Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr
Glu Arg Asn Glu Leu Ala 355 360 365 Pro Asn Lys Pro Asn Glu Arg Glu
Leu Ala Arg Arg Arg Gly Gly Tyr 370 375 380 Ala Gly Gly Tyr Val Lys
Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 385 390 395 400 Val Tyr Leu
Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 405 410 415 Asn
Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 420 425
430 Arg Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Val Pro Gly Phe
435 440 445 Ile Pro Ser Leu Leu Gly Ser Leu Leu Asp Glu Arg Gln Lys
Ile Lys 450 455 460 Arg Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys
Lys Leu Leu Asp 465 470 475 480 Tyr Arg Gln Arg Ala Ile Lys Ile Leu
Ala Asn Ser Tyr Tyr Gly Tyr 485 490 495 Tyr Gly Tyr Ala Arg Ala Arg
Trp Tyr Cys Arg Glu Cys Ala Glu Ser 500 505 510 Val Thr Ala Trp Gly
Arg Glu Tyr Ile Glu Met Ala Ile Arg Glu Leu 515 520 525 Glu Glu Lys
Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 530 535 540 His
Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 545 550
555 560 Met Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu
Glu 565 570 575 Leu Glu Tyr Glu Gly Phe Tyr Ala Arg Gly Phe Phe Val
Thr Lys Lys 580 585 590 Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile
Thr Thr Arg Gly Leu 595 600 605 Glu Ile Val Arg Arg Asp Trp Ser Glu
Ile Ala Lys Glu Thr Gln Ala 610 615 620 Arg Val Leu Glu Ala Ile Leu
Arg His Gly Asp Val Glu Glu Ala Val 625 630 635 640 Arg Ile Val Lys
Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 645 650 655 Pro Glu
Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp 660 665 670
Tyr Arg Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Lys 675
680 685 Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val
Leu 690 695 700 Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe
Asp Glu Phe 705 710 715 720 Asp Pro Thr Lys His Lys Tyr Asp Ala Glu
Tyr Tyr Ile Glu Asn Gln 725 730 735 Val Leu Pro Ala Val Glu Arg Val
Leu Lys Ala Phe Gly Tyr Arg Lys 740 745 750 Asp Asp Leu Arg Tyr Gln
Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 755 760 765 Leu Lys Val Lys
Lys Arg 770 45773PRTThermococcus waiotapuensis 45Met Ile Leu Asp
Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 1 5 10 15 Arg Val
Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Asn Tyr Asp Arg 20 25 30
Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 35
40 45 Glu Asp Ile Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val
Arg 50 55 60 Val Thr Arg Ala Glu Arg Val Lys Lys Lys Phe Leu Gly
Arg Pro Val 65 70 75 80 Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln
Asp Val Pro Ala Ile 85 90 95 Arg Asp Lys Ile Arg Glu His Pro Ala
Val Val Asp Ile Tyr Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg
Tyr Leu Ile Asp Lys Gly Leu Ile Pro 115 120 125 Met Glu Gly Asn Glu
Glu Leu Arg Met Leu Ala Phe Asp Ile Glu Thr 130 135 140 Leu Tyr His
Glu Gly Glu Glu Phe Gly Glu Gly Pro Ile Leu Met Ile 145 150 155 160
Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 165
170 175 Asp Leu Pro Tyr Val Glu Ser Val Ser Thr Glu Lys Glu Met Ile
Lys 180 185 190 Arg Phe Leu Lys Val Ile Gln Glu Lys Asp Pro Asp Val
Leu Ile Thr 195 200 205 Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu
Lys Lys Arg Ser Glu 210 215 220 Thr Leu Gly Val Lys Phe Ile Leu Gly
Arg Asp Gly Ser Glu Pro Lys 225 230 235 240 Ile Gln Arg Met Gly Asp
Arg Phe Ala Val Glu Val Lys Gly Arg Ile 245 250 255 His Phe Asp Leu
Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 260 265 270 Tyr Thr
Leu Glu Thr Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 275 280 285
Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 290
295 300 Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr
Tyr 305 310 315 320 Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln
Leu Ser Arg Leu 325 330 335 Val Gly Gln Ser Leu Trp Asp Val Ser Arg
Ser Ser Thr Gly Asn Leu 340 345 350 Val Glu Trp Phe Leu Leu Arg Lys
Ala Tyr Glu Arg Asn Glu Leu Ala 355 360 365 Pro Asn Lys Pro Asp Glu
Arg Glu Leu Ala Arg Arg Ala Glu Ser Tyr 370 375 380 Ala Gly Gly Tyr
Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile 385 390 395 400 Val
Tyr Leu Asp Tyr Lys Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 405 410
415 Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr Asp
420 425 430 Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro
Gly Phe 435 440 445 Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg
Gln Lys Val Lys 450 455 460 Lys Lys Met Lys Ala Thr Val Asp Pro Ile
Glu Arg Lys Leu Leu Asp 465 470 475 480 Tyr Arg Gln Arg Ala Ile Lys
Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 485 490 495 Tyr Gly Tyr Ala Asn
Ala Arg Trp Tyr Cys Arg Glu Cys Ala Glu Ser 500 505 510 Val Thr Ala
Trp Gly Arg Gln Tyr Ile Glu Thr Thr Met Arg Glu Ile 515 520 525 Glu
Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 530 535
540 Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Thr
545 550 555 560 Lys Glu Phe Leu Asn Tyr Ile Asn Pro Arg Leu Pro Gly
Leu Leu Glu 565 570 575 Leu Glu Tyr Glu Gly Phe Tyr Arg Arg Gly Phe
Phe Val Thr Lys Lys 580 585 590 Lys Tyr Ala Val Ile Asp Glu Glu Asp
Lys Ile Thr Thr Arg Gly Leu 595 600 605 Glu Ile Val Arg Arg Asp Trp
Ser Glu Ile Ala Lys Glu Thr Gln Ala 610 615 620 Arg Val Leu Glu Ala
Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 625 630 635 640 Arg Ile
Val Lys Glu Val Thr Glu Lys Leu Ser Arg Tyr Glu Val Pro 645 650 655
Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asn Leu Arg Asp 660
665 670 Tyr Arg Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala
Ala 675 680 685 Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr
Ile Val Leu 690 695 700 Lys Gly Pro Gly Arg Val Gly Asp Arg Ala Ile
Pro Phe Asp Glu Phe 705 710 715 720 Asp Pro Ala Lys His Arg Tyr Asp
Ala Glu Tyr Tyr Ile Glu Asn Gln 725 730 735 Val Leu Pro Ala Val Glu
Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 740 745 750 Glu Asp Leu Arg
Tyr Gln Lys Thr Lys Gln Ala Gly Leu Gly Ala Trp 755 760 765 Leu Lys
Pro Lys Thr 770 46774PRTThermococcus sibiricus 46Met Ile Leu Gly
Ala Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Val 1 5 10 15 Arg Ile
Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 20 25 30
His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Ser Glu Asp Ser Ala Ile 35
40 45 Asp Glu Ile Lys Gln Ile Lys Gly Glu Arg His Gly Lys Thr Val
Arg 50 55 60 Ile Val Asp Ala Val Lys Val Glu Lys Lys Phe Leu Lys
Lys Pro Val 65 70 75 80 Lys Val Trp Lys Leu Ile Leu Glu His Pro Gln
Asp Val Pro Ala Ile 85 90 95 Arg Asn Lys Ile Arg Glu His Pro Ala
Val Gln Asp Ile Tyr Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg
Tyr Leu Ile Asp Asn Gly Leu Ile Pro 115 120 125 Met Glu Gly Asp Glu
Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 130 135 140 Phe Tyr His
Glu Gly Asp Glu Phe Gly Lys Gly
Glu Ile Ile Met Ile 145 150 155 160 Ser Tyr Ala Asp Glu Glu Gly Ala
Arg Val Ile Thr Trp Lys Asn Ile 165 170 175 Asp Leu Pro Tyr Val Asp
Val Val Ser Asn Glu Arg Glu Met Ile Lys 180 185 190 Arg Phe Ile Gln
Ile Ile Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 195 200 205 Tyr Asn
Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 210 215 220
Lys Leu Gly Leu Arg Leu Ile Leu Ser Arg Asp Asn Glu Asn Pro Val 225
230 235 240 Pro Lys Ile Gln Arg Met Gly Asn Ser Phe Ala Val Glu Ile
Lys Gly 245 250 255 Arg Ile His Phe Asp Leu Phe Pro Val Val Lys Arg
Ala Val Asn Leu 260 265 270 Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu
Thr Val Leu Gly Lys His 275 280 285 Lys Ser Lys Leu Gly Ala Glu Glu
Ile Ala Ala Ile Trp Glu Thr Glu 290 295 300 Glu Gly Leu Lys Lys Leu
Ala Gln Tyr Ser Met Glu Asp Ala Lys Ala 305 310 315 320 Thr Tyr Glu
Leu Gly Arg Glu Phe Phe Pro Met Glu Val Glu Leu Ala 325 330 335 Lys
Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 340 345
350 Asn Leu Val Glu Trp Tyr Met Leu Arg Val Ala Tyr Glu Arg Asn Glu
355 360 365 Leu Ala Pro Asn Arg Pro Ser Asp Glu Glu Tyr Lys Arg Arg
Leu Arg 370 375 380 Thr Thr Tyr Leu Gly Gly Tyr Val Lys Glu Pro Glu
Arg Gly Leu Trp 385 390 395 400 Glu Asn Ile Ile Tyr Leu Asp Phe Arg
Ser Leu Tyr Pro Ser Ile Ile 405 410 415 Val Thr His Asn Val Ser Pro
Asp Thr Leu Glu Arg Lys Gly Cys Gln 420 425 430 Asn Tyr Asp Val Ala
Pro Ile Val Gly Tyr Lys Phe Cys Lys Asp Phe 435 440 445 Ser Gly Phe
Ile Pro Ser Ile Leu Glu Asp Leu Ile Glu Thr Arg Gln 450 455 460 Lys
Ile Lys Lys Glu Met Lys Ser Thr Ile Asp Pro Ile Lys Lys Lys 465 470
475 480 Met Leu Asp Tyr Arg Gln Arg Ala Val Lys Leu Leu Ala Asn Ser
Tyr 485 490 495 Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser
Lys Glu Cys 500 505 510 Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr
Ile Glu Met Thr Ile 515 520 525 Arg Glu Ile Glu Glu Lys Phe Gly Phe
Lys Val Leu Tyr Ala Asp Thr 530 535 540 Asp Gly Phe Tyr Ala Thr Ile
Pro Gly Ala Asp Pro Glu Thr Ile Lys 545 550 555 560 Lys Lys Ala Lys
Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 565 570 575 Leu Leu
Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 580 585 590
Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Glu Lys Ile Thr Thr 595
600 605 Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys
Glu 610 615 620 Thr Gln Ala Arg Val Leu Glu Ala Ile Leu Arg Glu Gly
Ser Val Glu 625 630 635 640 Lys Ala Val Glu Ile Val Lys Glu Val Val
Glu Ala Ile Thr Lys Tyr 645 650 655 Lys Val Pro Leu Glu Lys Leu Ile
Ile His Glu Gln Ile Thr Arg Glu 660 665 670 Leu Arg Asp Tyr Lys Ala
Val Gly Pro His Val Ala Ile Ala Lys Arg 675 680 685 Leu Ala Ala Lys
Gly Ile Lys Ile Lys Pro Gly Thr Ile Ile Ser Tyr 690 695 700 Ile Val
Leu Arg Gly Ser Gly Lys Ile Ser Asp Arg Val Val Leu Leu 705 710 715
720 Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile
725 730 735 Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala
Phe Gly 740 745 750 Tyr Arg Lys Glu Asp Leu Lys Tyr Gln Ser Ser Lys
Gln Thr Gly Leu 755 760 765 Glu Ser Trp Leu Lys Lys 770
47775PRTPyrococcus glycovorans 47Met Ile Leu Asp Ala Asp Tyr Ile
Thr Glu Asp Gly Lys Pro Ile Ile 1 5 10 15 Arg Ile Phe Lys Lys Glu
Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 20 25 30 Asn Phe Arg Pro
Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 35 40 45 Asp Glu
Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 50 55 60
Ile Val Asp Val Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 65
70 75 80 Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp Val Pro
Ala Ile 85 90 95 Arg Asp Lys Ile Arg Glu His Pro Ala Val Val Asp
Ile Phe Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile
Asp Lys Gly Leu Ile Pro 115 120 125 Met Glu Gly Asp Glu Glu Leu Lys
Leu Leu Ala Phe Asp Ile Glu Thr 130 135 140 Leu Tyr His Glu Gly Glu
Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 145 150 155 160 Ser Tyr Ala
Asp Glu Glu Gly Ala Lys Val Ile Thr Trp Lys Lys Val 165 170 175 Asp
Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 180 185
190 Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr
195 200 205 Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg
Ala Glu 210 215 220 Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly
Ser Glu Pro Lys 225 230 235 240 Met Gln Arg Leu Gly Asp Met Thr Ala
Val Glu Ile Lys Gly Arg Ile 245 250 255 His Phe Asp Leu Tyr His Val
Ile Arg Arg Thr Ile Asn Leu Pro Thr 260 265 270 Tyr Thr Leu Glu Ala
Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 275 280 285 Lys Val Tyr
Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 290 295 300 Leu
Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 305 310
315 320 Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg
Leu 325 330 335 Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr
Gly Asn Leu 340 345 350 Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu
Arg Asn Glu Leu Ala 355 360 365 Pro Asn Lys Pro Asp Glu Arg Glu Tyr
Glu Arg Arg Leu Arg Glu Ser 370 375 380 Tyr Ala Gly Gly Tyr Val Lys
Glu Pro Glu Lys Gly Leu Trp Glu Gly 385 390 395 400 Leu Val Ser Leu
Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 405 410 415 His Asn
Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Met Glu Tyr 420 425 430
Asp Val Ala Pro Glu Val Lys His Lys Phe Cys Lys Asp Phe Pro Gly 435
440 445 Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu
Ile 450 455 460 Lys Arg Arg Met Lys Ala Ser Lys Asp Pro Ile Glu Lys
Lys Met Leu 465 470 475 480 Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu
Ala Asn Ser Tyr Tyr Gly 485 490 495 Tyr Tyr Gly Tyr Ala Lys Ala Arg
Trp Tyr Cys Lys Glu Cys Ala Glu 500 505 510 Ser Val Thr Ala Trp Gly
Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 515 520 525 Leu Glu Glu Lys
Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 530 535 540 Leu Tyr
Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Arg Lys 545 550 555
560 Ala Leu Glu Phe Val Glu Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu
565 570 575 Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val
Thr Lys 580 585 590 Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile
Ile Thr Arg Gly 595 600 605 Leu Glu Ile Val Arg Arg Asp Trp Ser Glu
Ile Ala Lys Glu Thr Gln 610 615 620 Ala Lys Val Leu Glu Ala Ile Leu
Lys His Gly Asn Val Glu Glu Ala 625 630 635 640 Val Lys Ile Val Lys
Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 645 650 655 Pro Pro Glu
Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 660 665 670 Glu
Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 675 680
685 Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val
690 695 700 Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala
Glu Glu 705 710 715 720 Phe Asp Pro Arg Lys His Lys Tyr Asp Ala Glu
Tyr Tyr Ile Glu Asn 725 730 735 Gln Val Leu Pro Ala Val Leu Arg Ile
Leu Glu Ala Phe Gly Tyr Arg 740 745 750 Lys Glu Asp Leu Arg Trp Gln
Lys Thr Lys Gln Thr Gly Leu Thr Ala 755 760 765 Trp Leu Asn Val Lys
Lys Lys 770 775 48775PRTPyrococcus sp. NA2 48Met Ile Leu Asp Ala
Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 1 5 10 15 Arg Leu Phe
Lys Lys Glu Asn Gly Arg Phe Lys Val Glu Tyr Asp Arg 20 25 30 Asn
Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 35 40
45 Asp Asp Val Arg Lys Ile Thr Ser Glu Arg His Gly Lys Val Val Arg
50 55 60 Val Ile Asp Val Glu Lys Val Lys Lys Lys Phe Leu Gly Arg
Pro Ile 65 70 75 80 Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln Asp
Val Pro Ala Met 85 90 95 Arg Asp Lys Ile Arg Glu His Pro Ala Val
Ile Asp Ile Phe Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg Tyr
Leu Ile Asp Lys Gly Leu Ile Pro 115 120 125 Met Glu Gly Asn Glu Glu
Leu Thr Phe Leu Ala Val Asp Ile Glu Thr 130 135 140 Leu Tyr His Glu
Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 145 150 155 160 Ser
Tyr Ala Asp Glu Glu Gly Ala Lys Val Ile Thr Trp Lys Lys Ile 165 170
175 Asp Leu Pro Tyr Val Glu Val Val Ala Asn Glu Arg Glu Met Ile Lys
180 185 190 Arg Leu Ile Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile
Ile Thr 195 200 205 Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu Leu
Lys Arg Ala Glu 210 215 220 Lys Leu Gly Met Lys Leu Pro Leu Gly Arg
Asp Asn Ser Glu Pro Lys 225 230 235 240 Met Gln Arg Leu Gly Asp Ser
Leu Ala Val Glu Ile Lys Gly Arg Ile 245 250 255 His Phe Asp Leu Phe
Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 260 265 270 Tyr Thr Leu
Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Gln Lys Glu 275 280 285 Lys
Val Tyr Pro His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 290 295
300 Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr
305 310 315 320 Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu
Ala Arg Leu 325 330 335 Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser
Ser Thr Gly Asn Leu 340 345 350 Val Glu Trp Tyr Leu Leu Arg Lys Ala
Tyr Glu Arg Asn Glu Leu Ala 355 360 365 Pro Asn Lys Pro Asp Glu Arg
Glu Tyr Glu Arg Arg Leu Arg Glu Ser 370 375 380 Tyr Glu Gly Gly Tyr
Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Gly 385 390 395 400 Ile Val
Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 405 410 415
His Asn Val Ser Pro Asp Thr Leu Asn Lys Glu Gly Cys Gly Glu Tyr 420
425 430 Asp Glu Ala Pro Glu Val Gly His Arg Phe Cys Lys Asp Phe Pro
Gly 435 440 445 Phe Ile Pro Ser Leu Leu Gly Ser Leu Leu Glu Glu Arg
Gln Lys Ile 450 455 460 Lys Lys Arg Met Lys Glu Ser Lys Asp Pro Val
Glu Arg Lys Leu Leu 465 470 475 480 Asp Tyr Arg Gln Arg Ala Ile Lys
Ile Leu Ala Asn Ser Phe Tyr Gly 485 490 495 Tyr Tyr Gly Tyr Ala Lys
Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 500 505 510 Ser Val Thr Ala
Trp Gly Arg Gln Tyr Ile Glu Leu Val Arg Arg Glu 515 520 525 Leu Glu
Glu Arg Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly Leu 530 535 540
Tyr Ala Thr Ile Pro Gly Glu Lys Asn Trp Glu Glu Ile Lys Arg Arg 545
550 555 560 Ala Leu Glu Phe Val Asn Tyr Ile Asn Ser Lys Leu Pro Gly
Ile Leu 565 570 575 Glu Leu Glu Tyr Glu Gly Phe Tyr Thr Arg Gly Phe
Phe Val Thr Lys 580 585 590 Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly
Lys Ile Val Thr Arg Gly 595 600 605 Leu Glu Ile Val Arg Arg Asp Trp
Ser Glu Ile Ala Lys Glu Thr Gln 610 615 620 Ala Lys Val Leu Glu Ala
Ile Leu Lys His Gly Asn Val Glu Glu Ala 625 630 635 640 Val Lys Ile
Val Lys Glu Val Thr Glu Lys Leu Ser Asn Tyr Glu Ile 645 650 655 Pro
Val Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu Asn 660 665
670 Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala
675 680 685 Ala Lys Gly Ile Lys Ile Lys Pro Gly Met Val Ile Gly Tyr
Val Val 690 695 700 Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile
Ala Ile Glu Glu 705 710 715 720 Phe Asp Gly Lys Lys His Lys Tyr Asp
Ala Glu Tyr Tyr Ile Glu Asn 725 730 735 Gln Val Leu Pro Ala Val Glu
Arg Ile Leu Lys Ala Phe Gly Tyr Lys 740 745 750 Arg Glu Asp Leu Arg
Trp Gln Lys Thr Lys Gln Val Gly Leu Gly Ala 755 760 765 Trp Leu Lys
Val Lys Lys Ser 770 775 49785PRTFerroglobus placidus 49Met Glu Gly
Trp Leu Leu Asp Ala Asp Tyr Ile Thr Ala Glu Asp Gly 1 5 10 15 Arg
Ala Val Val Arg Leu Trp Cys Lys Asp Phe Asp Gly Asn Thr Phe 20 25
30 Val Val Tyr Asp Arg Asn Phe Gln Pro Tyr Phe Tyr Ala Phe Lys Asn
35 40 45 Gly Leu Ser Lys Glu Asp Ile Glu Lys Ile Val Val Lys Ser
Arg Glu 50 55 60 Gly Val Ile Lys Pro Phe Lys Val Glu Glu Val Arg
Arg Lys Val Phe 65 70 75 80 Gly Lys Glu Val Glu Val Phe Lys Ile Tyr
Ala Tyr His Pro Gln His 85 90 95 Val Pro Lys Leu Arg Glu Glu Leu
Lys Lys Ile Thr Glu Val Arg Glu 100 105 110 Ala Asp Ile Pro Phe Ala
Tyr Arg Tyr
Leu Ile Asp Lys Asp Leu Ala 115 120 125 Cys Met Asp Gly Ile Arg Val
Glu Gly Lys Val Arg Glu Glu Arg Gly 130 135 140 Leu Lys Val Ile Asp
Ala Glu His Val Glu Arg Phe Glu Ile Pro Leu 145 150 155 160 Pro Glu
Pro Lys Val Leu Ala Phe Asp Cys Glu Met Leu Thr Glu Leu 165 170 175
Gly Met Pro Asp Pro Glu Lys Asp Lys Ile Ile Ile Ile Gly Val Lys 180
185 190 Cys Gly Asp Phe Glu Glu Ile Ile Thr Gly Asn Glu Arg Glu Ile
Leu 195 200 205 Leu Arg Phe Val Glu Ile Ile Lys Glu Gln Asp Pro Asp
Val Ile Val 210 215 220 Gly Tyr Asn Gln Asp Asn Phe Asp Trp Pro Tyr
Ile Arg Lys Arg Ala 225 230 235 240 Glu Lys Leu Ser Val Lys Leu Asn
Ile Gly Arg Asp Gly Ser Glu Ile 245 250 255 Ser Phe Arg Gly Gly Arg
Pro Lys Ile Ala Gly Arg Leu Asn Val Asp 260 265 270 Leu Tyr Asp Ile
Ala Met Lys Leu Asp Val Lys Val Lys Thr Leu Glu 275 280 285 Asn Val
Ala Glu Phe Leu Gly Arg Lys Val Glu Leu Ala Asp Ile Glu 290 295 300
Ala Lys Asp Ile Tyr Lys Arg Trp Thr Ser Gly Asp Lys Glu Ser Val 305
310 315 320 Leu Lys Tyr Ser Lys Gln Asp Val Leu Asn Thr Tyr Phe Ile
Ala Glu 325 330 335 Glu Leu Leu Pro Met His Tyr Glu Leu Ser Arg Met
Ile Arg Ile Pro 340 345 350 Thr Asp Asp Val Ala Arg Ile Gly Arg Gly
Lys Gln Val Asp Trp Phe 355 360 365 Leu Leu Ser Glu Ala Tyr Lys Ile
Gly Glu Ile Ala Pro Asn Pro Ala 370 375 380 Glu Val Glu Glu Ser Tyr
Glu Gly Ala Phe Val Leu Glu Pro Ser Arg 385 390 395 400 Gly Leu His
Lys Asn Val Val Cys Leu Asp Phe Ala Ser Met Tyr Pro 405 410 415 Ser
Ile Met Ile Ala Tyr Asn Ile Ser Pro Asp Thr Tyr Val Phe Gly 420 425
430 Lys Cys Asp Asp Cys Tyr Val Ala Pro Glu Val Gly His Lys Phe Arg
435 440 445 Lys His Pro Asp Gly Phe Phe Lys Arg Ile Leu Lys Met Leu
Ile Glu 450 455 460 Lys Arg Arg Glu Ile Lys Asn Gln Met Lys Ser Leu
Asp Arg Asn Ser 465 470 475 480 Arg Glu Tyr Leu Leu Leu Asn Ile Lys
Gln Gln Thr Leu Lys Ile Leu 485 490 495 Thr Asn Ser Phe Tyr Gly Tyr
Thr Gly Trp Ser Gly Ala Arg Trp Tyr 500 505 510 Cys Arg Gln Cys Ala
Glu Ala Thr Thr Ala Trp Gly Arg His Leu Ile 515 520 525 Lys Ser Ala
Val Glu Ile Ala Lys Lys Leu Gly Phe Glu Val Leu Tyr 530 535 540 Gly
Asp Thr Asp Ser Ile Phe Val Lys Lys Gly Asn Leu Ser Leu Glu 545 550
555 560 Lys Ile Arg Gly Glu Val Glu Lys Leu Ile Glu Glu Ile Ser Glu
Lys 565 570 575 Phe Pro Val Gln Ile Glu Val Asp Glu Tyr Tyr Lys Thr
Ile Phe Phe 580 585 590 Val Glu Lys Lys Arg Tyr Ala Gly Leu Thr Glu
Asp Gly Ile Leu Val 595 600 605 Val Lys Gly Leu Glu Val Arg Arg Gly
Asp Trp Cys Glu Leu Ala Lys 610 615 620 Glu Val Gln Lys Lys Val Ile
Glu Ile Ile Leu Lys Glu Glu Asn Pro 625 630 635 640 Glu Lys Ala Ala
Glu Tyr Val Arg Lys Val Ile Asn Asp Ile Lys Ser 645 650 655 Gly Lys
Val Lys Leu Glu Asp Val Val Ile Tyr Lys Gly Leu Thr Lys 660 665 670
Arg Pro Asp Lys Tyr Glu Ser Lys Gln Ala His Val Lys Ala Ala Leu 675
680 685 Arg Ala Met Glu Leu Gly Ile Val Tyr Asn Val Gly Ser Lys Val
Gly 690 695 700 Phe Val Val Val Glu Gly Ala Gly Asn Val Gly Asp Arg
Ala Tyr Pro 705 710 715 720 Ile Asp Leu Ile Glu Glu Phe Asp Gly Glu
Asn Leu Val Ile Arg Thr 725 730 735 Arg Ser Gly Ser Ile Val Lys Lys
Leu Asp Lys Asp Tyr Tyr Ile Asn 740 745 750 His Gln Ile Ile Pro Ser
Val Leu Arg Ile Leu Glu Arg Phe Gly Tyr 755 760 765 Asn Glu Ala Ser
Leu Lys Gly Ala Thr Gln Lys Thr Leu Asp Ala Phe 770 775 780 Trp 785
50775PRTPalaeococcus ferrophilus 50Met Ile Leu Asp Ala Asp Tyr Ile
Thr Glu Asn Gly Lys Pro Val Val 1 5 10 15 Arg Ile Phe Lys Lys Glu
Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 20 25 30 Asn Phe Glu Pro
Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 35 40 45 Glu Glu
Ile Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Arg 50 55 60
Ile Thr Lys Ala Glu Lys Val Glu Arg Lys Phe Leu Gly Arg Pro Val 65
70 75 80 Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro
Ala Ile 85 90 95 Arg Asp Lys Ile Arg Ser His Pro Ala Val Val Asp
Ile Tyr Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile
Asp Lys Gly Leu Val Pro 115 120 125 Met Glu Gly Asp Glu Glu Leu Lys
Met Leu Ala Phe Asp Ile Glu Thr 130 135 140 Leu Tyr His Glu Gly Glu
Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 145 150 155 160 Ser Tyr Ala
Asp Glu Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Val 165 170 175 Asp
Leu Pro Tyr Val Asp Ala Val Ser Thr Glu Lys Asp Met Ile Lys 180 185
190 Ala Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr
195 200 205 Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg
Cys Glu 210 215 220 Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Asp Gly
Ser Glu Pro Lys 225 230 235 240 Ile Gln Arg Met Gly Asp Arg Phe Ala
Val Asp Val Lys Gly Arg Ile 245 250 255 His Phe Asp Leu Tyr Pro Val
Ile Arg Arg Thr Ile Asn Leu Pro Thr 260 265 270 Tyr Thr Leu Glu Ala
Val Tyr Glu Ala Ile Phe Gly Arg Pro Lys Glu 275 280 285 Lys Val Tyr
Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Asn Glu Gly 290 295 300 Leu
Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 305 310
315 320 Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg
Leu 325 330 335 Ile Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr
Gly Asn Leu 340 345 350 Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu
Arg Asn Glu Leu Ala 355 360 365 Pro Asn Lys Pro Ser Gly Arg Glu Tyr
Asp Glu Arg Arg Gly Gly Tyr 370 375 380 Ala Gly Gly Tyr Val Lys Glu
Pro Glu Lys Gly Leu Trp Glu Asn Ile 385 390 395 400 Val Tyr Leu Asp
Tyr Lys Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 405 410 415 Asn Val
Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 420 425 430
Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 435
440 445 Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile
Lys 450 455 460 Arg Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Arg
Leu Leu Asp 465 470 475 480 Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala
Asn Ser Tyr Tyr Gly Tyr 485 490 495 Tyr Gly Tyr Ala Arg Ala Arg Trp
Tyr Cys Lys Glu Cys Ala Glu Ser 500 505 510 Val Thr Ala Trp Gly Arg
Glu Tyr Ile Glu Met Ser Ile Arg Glu Ile 515 520 525 Glu Glu Lys Tyr
Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 530 535 540 His Ala
Thr Ile Pro Gly Glu Asp Ala Glu Thr Ile Lys Lys Lys Ala 545 550 555
560 Met Glu Phe Leu Lys Tyr Ile Asn Ser Lys Leu Pro Gly Ala Leu Glu
565 570 575 Leu Glu Tyr Glu Gly Phe Tyr Arg Arg Gly Phe Phe Val Thr
Lys Lys 580 585 590 Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr
Thr Arg Gly Leu 595 600 605 Glu Ile Val Arg Arg Asp Trp Ser Glu Ile
Ala Lys Glu Thr Gln Ala 610 615 620 Arg Val Leu Glu Ala Leu Leu Lys
Asp Gly Asn Val Glu Glu Ala Val 625 630 635 640 Ser Ile Val Lys Glu
Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 645 650 655 Pro Glu Lys
Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp 660 665 670 Tyr
Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala Ala 675 680
685 Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu
690 695 700 Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp
Glu Phe 705 710 715 720 Asp Pro Ala Lys His Arg Tyr Asp Ala Glu Tyr
Tyr Ile Glu Asn Gln 725 730 735 Val Leu Pro Ala Val Glu Arg Ile Leu
Lys Ala Phe Gly Tyr Arg Lys 740 745 750 Glu Asp Leu Arg Tyr Gln Lys
Thr Arg Gln Val Gly Leu Gly Ala Trp 755 760 765 Leu Lys Pro Lys Gly
Lys Lys 770 775 51775PRTThermococcus gammatolerans 51Met Ile Leu
Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 1 5 10 15 Arg
Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 20 25
30 Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile
35 40 45 Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Ala Val
Val Lys 50 55 60 Val Lys Arg Ala Glu Lys Val Gln Arg Lys Phe Leu
Gly Arg Pro Ile 65 70 75 80 Glu Val Trp Lys Leu Tyr Phe Thr His Pro
Gln Asp Val Pro Ala Ile 85 90 95 Arg Asp Lys Ile Arg Ala His Pro
Ala Val Val Asp Ile Tyr Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys
Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 115 120 125 Met Glu Gly Asp
Glu Glu Leu Arg Met Leu Ala Phe Asp Ile Glu Thr 130 135 140 Leu Tyr
His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 145 150 155
160 Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile
165 170 175 Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met
Ile Lys 180 185 190 Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp
Val Leu Ile Thr 195 200 205 Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr
Leu Lys Lys Arg Cys Glu 210 215 220 Lys Leu Gly Ile Lys Phe Thr Leu
Gly Arg Asp Gly Ser Glu Pro Lys 225 230 235 240 Ile Gln Arg Met Gly
Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 245 250 255 His Phe Asp
Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 260 265 270 Tyr
Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 275 280
285 Lys Val Tyr Ala Glu Glu Ile Thr Glu Ala Trp Glu Ser Gly Glu Gly
290 295 300 Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val
Thr Tyr 305 310 315 320 Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala
Gln Leu Ser Arg Leu 325 330 335 Ile Gly Gln Ser Leu Trp Asp Val Ser
Arg Ser Ser Thr Gly Asn Leu 340 345 350 Val Glu Trp Phe Leu Leu Arg
Lys Ala Tyr Glu Arg Asn Glu Leu Ala 355 360 365 Pro Asn Lys Pro Asp
Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 370 375 380 Ala Gly Gly
Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 385 390 395 400
Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 405
410 415 Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr
Asp 420 425 430 Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe
Pro Gly Phe 435 440 445 Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu
Arg Gln Lys Ile Lys 450 455 460 Arg Lys Met Lys Ala Thr Ile Asp Pro
Leu Glu Lys Lys Leu Leu Asp 465 470 475 480 Tyr Arg Gln Arg Ala Ile
Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 485 490 495 Tyr Gly Tyr Ala
Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 500 505 510 Val Thr
Ala Trp Gly Arg Glu Tyr Ile Glu Thr Thr Ile Arg Glu Ile 515 520 525
Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 530
535 540 Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys
Ala 545 550 555 560 Lys Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro
Gly Leu Leu Glu 565 570 575 Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly
Phe Phe Val Thr Lys Lys 580 585 590 Lys Tyr Ala Val Ile Asp Glu Glu
Gly Lys Ile Thr Thr Arg Gly Leu 595 600 605 Glu Ile Val Arg Arg Asp
Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 610 615 620 Arg Val Leu Glu
Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 625 630 635 640 Arg
Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 645 650
655 Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp
660 665 670 Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu
Ala Ala 675 680 685 Lys Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser
Tyr Ile Val Leu 690 695 700 Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala
Ile Pro Ala Asp Glu Phe 705 710 715 720 Asp Pro Thr Lys His Arg Tyr
Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 725 730 735 Val Leu Pro Ala Val
Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 740 745 750 Glu Asp Leu
Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 755 760 765 Leu
Lys Val Lys Gly Lys Lys 770 775 52775PRTThermococcus celericrescens
52Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 1
5 10 15 Arg Ile Phe Lys Lys Asp Asn Gly Glu Phe Lys Ile Glu Tyr Asp
Arg 20 25 30 Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp
Ser Ala Ile 35 40 45 Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His
Gly Arg Val Val Lys 50 55 60 Val Lys Arg Ala Glu Lys Val Lys Lys
Lys Phe Leu Gly
Arg Pro Val 65 70 75 80 Glu Val Trp Lys Leu Tyr Phe Thr Arg Pro Gln
Asp Val Pro Ala Ile 85 90 95 Arg Asp Arg Ile Arg Ala His Pro Ala
Val Val Asp Ile Tyr Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg
Tyr Leu Ile Asp Lys Gly Ile Ile Pro 115 120 125 Met Glu Gly Asp Glu
Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 130 135 140 Leu Tyr His
Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 145 150 155 160
Ser Tyr Ala Asp Glu Asn Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 165
170 175 Asp Leu Pro Phe Val Asp Val Val Ser Thr Glu Lys Glu Met Ile
Lys 180 185 190 Arg Phe Leu Lys Val Ile Lys Glu Lys Asp Pro Asp Val
Leu Ile Thr 195 200 205 Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu
Lys Lys Arg Cys Glu 210 215 220 Lys Phe Gly Ile Lys Phe Thr Leu Gly
Arg Asp Gly Ser Asp Pro Lys 225 230 235 240 Ile Gln Arg Met Gly Asp
Arg Phe Ala Val Glu Val Lys Gly Arg Ile 245 250 255 His Phe Asp Leu
Tyr Pro Val Ile Leu Arg Thr Val Asn Leu Pro Thr 260 265 270 Tyr Thr
Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Thr Pro Lys Glu 275 280 285
Lys Val Tyr Pro Glu Glu Ile Thr Thr Ala Trp Glu Thr Gly Glu Gly 290
295 300 Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr
Phe 305 310 315 320 Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln
Leu Ser Arg Leu 325 330 335 Val Gly Gln Ser Phe Trp Asp Val Ser Arg
Ser Ser Thr Gly Asn Leu 340 345 350 Val Glu Trp Phe Leu Leu Arg Lys
Ala Tyr Glu Arg Asn Glu Leu Ala 355 360 365 Pro Asn Lys Pro Asp Glu
Arg Glu Leu Val Arg Arg Arg Asn Ser Tyr 370 375 380 Thr Gly Gly Tyr
Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 385 390 395 400 Val
Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 405 410
415 Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp
420 425 430 Glu Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro
Gly Phe 435 440 445 Ile Pro Ser Leu Leu Gly Asn Leu Leu Asp Glu Arg
Gln Lys Ile Lys 450 455 460 Lys Arg Met Lys Ala Thr Ile Asp Pro Leu
Glu Lys Lys Leu Leu Asp 465 470 475 480 Tyr Arg Gln Arg Ala Ile Lys
Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 485 490 495 Tyr Ala Tyr Ala Arg
Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 500 505 510 Val Thr Ala
Trp Gly Arg Glu Tyr Ile Glu Met Ser Ile Arg Glu Ile 515 520 525 Glu
Glu Lys Tyr Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 530 535
540 His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala
545 550 555 560 Met Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly
Ala Leu Glu 565 570 575 Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe
Phe Val Thr Lys Lys 580 585 590 Lys Tyr Ala Val Ile Asp Glu Glu Gly
Lys Ile Thr Thr Arg Gly Leu 595 600 605 Glu Ile Val Arg Arg Asp Trp
Ser Glu Ile Ala Lys Glu Thr Gln Ala 610 615 620 Arg Val Leu Glu Ala
Leu Leu Lys Asp Gly Asn Val Glu Glu Ala Val 625 630 635 640 Ser Ile
Val Lys Glu Val Thr Glu Lys Leu Gly Lys Tyr Glu Val Pro 645 650 655
Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Glu Leu Lys Asp 660
665 670 Tyr Lys Ala Thr Gly Pro His Val Ala Ile Ala Lys Arg Leu Ala
Ala 675 680 685 Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr
Ile Val Leu 690 695 700 Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile
Pro Phe Asp Glu Phe 705 710 715 720 Asp Pro Thr Lys His Arg Tyr Asp
Ala Glu Tyr Tyr Ile Glu Asn Gln 725 730 735 Val Leu Pro Ala Val Glu
Arg Ile Leu Lys Ala Phe Gly Tyr Arg Ala 740 745 750 Glu Asp Leu Arg
Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Val Trp 755 760 765 Leu Gln
Pro Lys Gly Lys Lys 770 775 53784PRTVulcanisaeta distributa 53Met
Glu Leu Ala Phe Trp Leu Leu Asp Ile Thr Tyr Gly Val Ile Gly 1 5 10
15 Asn Thr Pro Glu Leu Arg Leu Phe Gly Ile Thr Asp Asp Gly Lys Arg
20 25 30 Val Leu Val Leu Asp Arg Ser Phe Arg Pro Tyr Phe Tyr Val
Ile Pro 35 40 45 Ser Gly Asp Val Asn Ala Val Phe Asn Asn Val Lys
Arg Lys Leu Glu 50 55 60 Gly Lys Val Leu Asn Val Glu Val Ile Lys
Arg Lys Met Phe Gly Asn 65 70 75 80 Glu Val Asp Ala Ile Arg Val Thr
Ala Thr Ile Pro Glu Lys Val Arg 85 90 95 Glu Leu Arg Glu Leu Ala
Ala Glu Val Pro Gly Val Glu Asp Val Leu 100 105 110 Glu Ala Asp Ile
Arg Phe Ser Gln Arg Tyr Leu Leu Asp Met Gly Val 115 120 125 Lys Pro
Ser Asn Trp Ile Val Val Asp Gln Cys Glu Glu Val Lys Gly 130 135 140
Asn Tyr Gln Val Asp Leu Val Cys Leu Ala Lys Ser Arg Pro Arg Met 145
150 155 160 Ile Glu Glu His Lys Leu Pro Ser Phe Arg Val Leu Ala Phe
Asp Ile 165 170 175 Glu Val Tyr Asn Pro Arg Gly Met Pro Asn Pro Asp
Arg Asp Pro Val 180 185 190 Ile Ile Ile Ser Thr Met Thr Lys Glu Asp
Gly Val Lys Met Phe Val 195 200 205 Val Asp Asp Asn Lys Asn Asp Ala
Lys Ile Ile Arg Glu Phe Leu Asp 210 215 220 Tyr Phe Arg Lys Tyr Asp
Pro Asp Ile Val Val Gly Tyr Asn Asn Asn 225 230 235 240 Gly Phe Asp
Trp Pro Tyr Leu Val Asn Arg Ser Ser Arg Val Gly Val 245 250 255 Arg
Leu Ala Leu Ser Arg Met Gly Asn Pro Pro Glu Pro Ser Val Tyr 260 265
270 Gly His Trp Ser Ile Ile Gly Arg Ala Asn Val Asp Leu Tyr Asn Phe
275 280 285 Ile Glu Glu Ile Ser Glu Ile Lys Val Lys Ser Leu Asp Arg
Ala Ala 290 295 300 Glu Phe Phe Gly Ile Met Lys Arg Ser Glu Arg Val
Leu Ile Pro Gly 305 310 315 320 His Arg Ile His Glu Tyr Trp Asp Asp
Lys Asn Lys Arg Asp Leu Leu 325 330 335 Leu Lys Tyr Ala Arg Asp Asp
Val Val Ser Thr Tyr Gly Leu Ala Glu 340 345 350 Lys Leu Leu Pro Phe
Ala Ile Gln Leu Ser Ser Ile Ser Gly Leu Pro 355 360 365 Leu Asp Gln
Val Gly Ala Ala Ser Val Gly Ala Arg Val Glu Trp Met 370 375 380 Ile
Phe Tyr Glu Ala Val Lys Arg Gly Glu Leu Ala Pro Asn Arg Glu 385 390
395 400 Glu Arg Pro Tyr Glu Thr Tyr Lys Gly Ala Val Val Leu Glu Pro
Arg 405 410 415 Pro Gly Leu His Glu Asn Ile Ala Val Ile Asp Phe Ser
Ser Met Tyr 420 425 430 Pro Ser Ile Met Met Lys Tyr Asn Val Ser Pro
Asp Thr Leu Val Leu 435 440 445 Gly Asp Cys Gly Asp Cys Tyr Val Ala
Pro Glu Val Asn Tyr Lys Phe 450 455 460 Arg Arg Ser Pro Glu Gly Leu
Tyr Pro Gly Leu Leu Arg Ile Leu Val 465 470 475 480 Glu Ser Arg Arg
Arg Val Arg Asp Leu Met Lys Lys Tyr Pro Glu Asn 485 490 495 Ser Pro
Glu Trp Val Leu Leu Asn Glu Arg Gln Arg Ala Leu Lys Val 500 505 510
Met Ala Asn Ala Met Tyr Gly Tyr Cys Gly Trp Leu Gly Ala Arg Trp 515
520 525 Tyr Arg Arg Glu Val Ala Glu Ala Val Thr Ala Trp Gly Arg Asn
Leu 530 535 540 Leu Arg Thr Val Ile Glu Lys Ala Arg Ser Leu Gly Leu
Pro Ile Ile 545 550 555 560 Tyr Gly Asp Thr Asp Ser Leu Phe Val Arg
Asn Ile Ser Asp Lys Val 565 570 575 Asp Ala Leu Ile Asn Tyr Val Asn
Asn Glu Leu Gly Phe Glu Val Lys 580 585 590 Val Asp Lys Val Tyr Arg
Arg Val Leu Phe Thr Glu Ala Lys Lys Arg 595 600 605 Tyr Val Gly Leu
Thr Val Glu Gly Glu Val Asp Ile Val Gly Phe Glu 610 615 620 Ala Val
Arg Gly Asp Trp Ala Glu Ile Ala Lys Asp Val Gln Glu Asn 625 630 635
640 Val Ala Glu Ile Val Leu Thr Thr Gly Asp Val Gly Lys Ala Ile Ser
645 650 655 Tyr Val Lys Ser Val Ile Asp Lys Val Lys Ala Tyr Gln Phe
Asp Ile 660 665 670 Asp Asp Val Ile Ile Trp Lys Thr Leu Asp Lys Ser
Leu Asn Glu Tyr 675 680 685 Lys Val Leu Thr Pro His Val Ala Ala Ala
Lys Gln Leu Val Glu Ala 690 695 700 Gly Tyr Lys Val Gly Lys Gly Asp
Met Ile Gly Tyr Val Val Val Lys 705 710 715 720 Gly Gly Gly Ala Lys
Leu Ala Tyr Lys Val Lys Pro Tyr Ile Leu Ile 725 730 735 Lys Asp Ile
Arg Glu Val Asp Val Asp Tyr Tyr Val Glu Lys Gln Ile 740 745 750 Val
Pro Ala Ala Met Arg Ile Leu Glu Val Leu Gly Val Lys Glu Ser 755 760
765 Gln Leu Met Glu Gly Lys Ala Gly Lys Ser Ile Leu Asp Tyr Phe Ser
770 775 780 54830PRTMethanopyrus kandleri 54Met Leu Arg Thr Val Trp
Val Asp Tyr Ala Arg Lys Gly Glu Pro Asp 1 5 10 15 Val Ile Leu Val
Gly Arg Arg Glu Asp Gly Asn Pro Ala Ala Leu Val 20 25 30 Val Lys
Gly Phe Arg Pro Tyr Phe Tyr Ala Glu Val Glu Asp Gly Phe 35 40 45
Asp Pro Ser Glu Val Glu Arg Leu Ser Gly Val Val Glu Val Glu Glu 50
55 60 Val Leu Leu Glu His Pro Tyr Gly Gly Asp Arg Val Glu Leu Leu
Arg 65 70 75 80 Ile Val Ala Thr Tyr Pro Lys Val Val Pro Lys Leu Arg
Glu Gln Val 85 90 95 Lys Lys Leu Asp Gly Val Lys Glu Val Tyr Glu
Ala Asp Ile Pro Phe 100 105 110 Val Arg Arg Ala Ala Val Asp Leu Asn
Leu Pro Pro Ala Ser Glu Val 115 120 125 Asp Val Ser Asp Leu Asp Thr
Gly Ser Trp Ser Gly Leu Pro Ala Tyr 130 135 140 Phe Ala Asp Val Glu
Asp Ala Arg Glu Leu Asp His Arg Pro Tyr Pro 145 150 155 160 Ile Glu
Asp Leu Val Val Ala Ser Phe Asp Leu Glu Val Leu Ala Glu 165 170 175
Pro Gly Thr Thr Ile Lys Gly Ala Ser Gly Pro Ile Ile Ala Ile Ser 180
185 190 Phe Ala Tyr Ser Thr Pro Asp Gly Glu Arg Arg Asn Tyr Val Ile
Thr 195 200 205 Trp Lys Gly Glu Asp Glu Ser Phe Glu Val Asp Gly Val
Glu Thr Glu 210 215 220 Val Ile Val Cys Arg Ser Glu Ala Ala Ala Leu
Arg Arg Phe Phe Asp 225 230 235 240 Glu Phe Arg Arg Val Asp Pro Asp
Val Val Phe Thr Tyr Asn Gly Asp 245 250 255 Glu Phe Asp Leu Pro Tyr
Leu Gln His Arg Ala Gly Lys Leu Gly Ile 260 265 270 Asp Val Ser Pro
Leu Ala Arg Pro Ala Gly Lys Arg Gly Ile Ile Leu 275 280 285 Lys His
Gly Gly Gly Arg Tyr Ala Ser Asp Ile Phe Gly Arg Ala His 290 295 300
Val Asp Leu Tyr His Thr Ala Arg Lys Asn Leu Lys Leu Glu Arg Phe 305
310 315 320 Thr Leu Glu Glu Ala Val Lys Asp Val Leu Gly Val Glu Lys
Glu Glu 325 330 335 Met Glu Leu Ala Asp Ile Asn Glu Ala Trp Lys Arg
Gly Asn Leu Asp 340 345 350 Glu Leu Met Arg Tyr Ser Ala Glu Asp Ala
His Tyr Thr Leu Glu Leu 355 360 365 Gly Leu Glu Leu Ala Gln Val Glu
Leu Glu Leu Ser Tyr Leu Thr Arg 370 375 380 Leu Pro Leu Pro Asp Ala
Thr Arg Phe Ser Phe Gly Gln Leu Ala Glu 385 390 395 400 Trp Arg Ala
Ile Tyr Lys Ala Arg Gln Glu Asp Ile Leu Val Pro Asn 405 410 415 Lys
Pro Thr Arg Asp Glu Tyr Lys Arg Arg Arg Arg Lys Ala Tyr Lys 420 425
430 Gly Ala Ile Val Phe Glu Pro Glu Ile Gly Leu His Glu Asn Val Val
435 440 445 Cys Val Asp Phe Ala Ser Leu Tyr Pro Asn Val Met Val Ala
His Asn 450 455 460 Ile Ser Pro Asp Thr Phe Asp Cys Asp Cys Cys Pro
Arg Val Thr Val 465 470 475 480 Glu Glu Val Asp Asp Pro Thr Asp Ala
Thr Val Ala Pro Asp Val Gly 485 490 495 His Lys Phe Cys Lys Arg Arg
Lys Gly Phe Phe Pro Arg Leu Val Glu 500 505 510 Gly Leu Ile Glu Arg
Arg Arg Glu Leu Lys Arg Arg Leu Arg Lys Leu 515 520 525 Asp Thr Glu
Ser His Pro His Glu Ala Lys Ile Leu Asp Val Arg Gln 530 535 540 Gln
Ala Tyr Lys Val Leu Ala Asn Ser Tyr Tyr Gly Tyr Met Gly Trp 545 550
555 560 Ala Asn Ala Arg Trp Phe Cys Arg Glu Cys Ala Glu Ser Val Thr
Ala 565 570 575 Trp Gly Arg Tyr Tyr Ile Ser Glu Val Arg Arg Ile Ala
Glu Glu Lys 580 585 590 Tyr Gly Leu Lys Val Val Tyr Gly Asp Thr Asp
Ser Leu Phe Val Lys 595 600 605 Leu Pro Asp Ala Asp Leu Glu Glu Thr
Ile Glu Arg Val Lys Glu Phe 610 615 620 Leu Lys Glu Val Asn Gly Arg
Leu Pro Val Glu Leu Glu Leu Glu Asp 625 630 635 640 Ala Tyr Lys Arg
Ile Leu Phe Val Thr Lys Lys Lys Tyr Ala Gly Tyr 645 650 655 Thr Glu
Asp Gly Lys Ile Val Thr Lys Gly Leu Glu Val Val Arg Arg 660 665 670
Asp Trp Ala Pro Ile Ala Arg Glu Thr Gln Arg Arg Val Leu Lys Arg 675
680 685 Ile Leu Ala Asp Asn Asp Pro Glu Ala Ala Leu Lys Glu Ile His
Glu 690 695 700 Val Leu Glu Arg Leu Lys Ser Gly Asp Val Asp Ile Asp
Glu Leu Ala 705 710 715 720 Val Thr Ser Gln Leu Thr Lys Lys Pro Ser
Glu Tyr Val Gln Lys Gly 725 730 735 Pro His Val Arg Ala Ala Leu Arg
Leu Ala Arg His Leu Gly Val Glu 740 745 750 Pro Glu Pro Gly Thr Ile
Val Arg Tyr Val Ile Val Arg Gly Pro Gly 755 760 765 Ser Val Ser Asp
Lys Ala Tyr Pro Val Glu Leu Val Arg Glu Glu Gly 770 775 780 Lys Glu
Pro Asp Val Asp Tyr Tyr Ile Glu His Gln Ile Leu Pro Ala 785 790 795
800 Val Glu Arg Ile Met Arg Ala Ile Gly Tyr Ser Arg Gly Gln Ile Val
805
810 815 Gly Glu Thr Ala Ser Gln Lys Thr Leu Asp Gln Phe Phe Gly 820
825 830 55784PRTThermoproteus neutrophilus 55Met Glu Leu Lys Ile
Trp Pro Leu Asp Val Thr Tyr Ala Val Val Gly 1 5 10 15 Gly Tyr Pro
Glu Val Arg Val Phe Gly Leu Thr Glu Gly Gly Gly Arg 20 25 30 Val
Val Leu Val Asp Arg Ser Phe Lys Pro Tyr Phe Tyr Val Asp Cys 35 40
45 Pro Thr Cys Glu Val Gly Val Val Lys Ser Ser Leu Ser Arg Val Ala
50 55 60 Pro Val Asp Glu Val Ser Ala Ala Glu Arg Arg Phe Leu Gly
Arg Pro 65 70 75 80 Arg Arg Phe Leu Met Val Val Ala Arg Val Pro Glu
Asp Val Arg Arg 85 90 95 Leu Arg Glu Ala Ala Ala Gln Ile Pro Gly
Val Ala Gly Val Tyr Glu 100 105 110 Ala Asp Ile Arg Phe Tyr Met Arg
Tyr Met Ile Asp Val Gly Leu Leu 115 120 125 Pro Cys Ser Trp Asn Arg
Ala Glu Val Glu Gly Gly Gly Lys Val Gly 130 135 140 Gly Leu Pro Gln
Tyr Thr Val Val Gln Trp Leu Gly Pro Ala Gly Gly 145 150 155 160 Phe
Pro Pro Pro Leu Arg Val Leu Ala Phe Asp Ile Glu Val Tyr Asn 165 170
175 Glu Arg Gly Thr Pro Asp Pro Ala Arg Asp Pro Val Val Met Ile Ala
180 185 190 Val Lys Thr Asp Asp Gly Arg Glu Glu Val Phe Glu Ala Glu
Gly Arg 195 200 205 Asp Asp Arg Gly Val Leu Arg Ser Phe Val Glu Phe
Val Lys Ser Tyr 210 215 220 Asp Pro Asp Val Val Val Gly Tyr Asn Ser
Asn Gly Phe Asp Trp Pro 225 230 235 240 Tyr Leu Ala Gly Arg Ala Arg
Ala Ile Gly Val Pro Leu Arg Val Asp 245 250 255 Arg Leu Gly Gly Leu
Pro Gln Gln Ser Val Tyr Gly His Trp Ser Ile 260 265 270 Val Gly Arg
Ala Asn Val Asp Leu Tyr Gly Ile Val Glu Glu Phe Pro 275 280 285 Glu
Ile Lys Leu Lys Thr Leu Asp Arg Val Ala Glu Tyr Phe Gly Val 290 295
300 Met Arg Arg Glu Glu Arg Val Leu Ile Pro Gly His Lys Ile Tyr Glu
305 310 315 320 Tyr Trp Arg Asp Pro Gly Lys Arg Pro Leu Leu Arg Gln
Tyr Val Leu 325 330 335 Asp Asp Val Arg Ser Thr Leu Gly Leu Ala Asp
Lys Leu Leu Pro Phe 340 345 350 Leu Ile Gln Leu Ser Ser Val Ser Gly
Leu Pro Leu Asp Gln Val Ala 355 360 365 Ala Ala Ser Val Gly Asn Arg
Val Glu Trp Met Leu Leu Arg Tyr Ala 370 375 380 Tyr Arg Leu Gly Glu
Val Ala Pro Asn Arg Glu Glu Arg Glu Tyr Glu 385 390 395 400 Pro Tyr
Lys Gly Ala Ile Val Leu Glu Pro Lys Pro Gly Met Tyr Glu 405 410 415
Asp Val Leu Val Leu Asp Phe Ser Ser Met Tyr Pro Asn Ile Met Met 420
425 430 Lys Tyr Asn Leu Ser Pro Asp Thr Tyr Leu Glu Pro Gly Glu Pro
Asp 435 440 445 Pro Pro Glu Gly Val Asn Ala Ala Pro Glu Val Gly His
Arg Phe Arg 450 455 460 Arg Ser Pro Leu Gly Phe Val Pro Gln Val Leu
Lys Ser Leu Val Glu 465 470 475 480 Leu Arg Lys Ala Val Arg Glu Glu
Ala Lys Arg Tyr Pro Pro Asp Ser 485 490 495 Pro Glu Phe Arg Ile Leu
Asp Glu Arg Gln Arg Ala Leu Lys Val Met 500 505 510 Ala Asn Ala Met
Tyr Gly Tyr Leu Gly Trp Val Gly Ala Arg Trp Tyr 515 520 525 Lys Arg
Glu Val Ala Glu Ser Val Thr Ala Phe Ala Arg Ala Ile Leu 530 535 540
Lys Asp Val Ile Glu Gln Ala Arg Arg Leu Gly Ile Val Val Val Tyr 545
550 555 560 Gly Asp Thr Asp Ser Leu Phe Val Lys Lys His Val Asn Val
Asp Lys 565 570 575 Leu Ile Gln Tyr Val Glu Glu Lys Tyr Gly Ile Glu
Ile Lys Val Asp 580 585 590 Lys Asp Tyr Ala Lys Val Leu Phe Thr Glu
Ala Lys Lys Arg Tyr Ala 595 600 605 Gly Leu Leu Arg Asp Gly Arg Ile
Asp Ile Val Gly Phe Glu Val Val 610 615 620 Arg Gly Asp Trp Ser Glu
Leu Ala Lys Glu Val Gln Leu Lys Val Val 625 630 635 640 Glu Ile Ile
Leu Asn Ser Arg Asp Val Ala Glu Ala Arg Arg Arg Val 645 650 655 Thr
Gln Tyr Val Arg Glu Ile Ile Glu Arg Leu Arg Glu Tyr Lys Phe 660 665
670 Asn Val Asp Asp Leu Ile Ile Trp Lys Thr Leu Asp Lys Glu Leu Gly
675 680 685 Glu Tyr Lys Ala Tyr Pro Pro His Val His Ala Ala Leu Ile
Leu Lys 690 695 700 Arg His Gly Tyr Lys Val Gly Lys Gly Asn Met Val
Gly Tyr Val Val 705 710 715 720 Val Lys Gly Gly Gly Lys Ile Ser Glu
Lys Ala Leu Pro Tyr Ile Leu 725 730 735 Leu Asp Asp Val Lys Lys Ile
Asp Val Glu Tyr Tyr Ile Glu Arg Gln 740 745 750 Ile Ile Pro Ala Ala
Leu Arg Ile Ala Glu Val Ile Gly Val Lys Glu 755 760 765 Ala Asp Leu
Lys Thr Gly Lys Ser Glu Arg Ser Leu Leu Asp Phe Phe 770 775 780
56142PRTPyrococcus furiosus 56Met Lys Thr Phe Leu Thr Glu Gln Gln
Ile Lys Val Leu Met Leu Arg 1 5 10 15 Ala Lys Gly Tyr Lys Gln Ser
Glu Ile Ala Lys Ile Leu Gly Thr Ser 20 25 30 Arg Ala Asn Val Ser
Ile Leu Glu Lys Arg Ala Met Glu Lys Ile Glu 35 40 45 Lys Ala Arg
Asn Thr Leu Leu Leu Trp Glu Gln Ile Asn Ser Lys Val 50 55 60 Ile
Val Glu Ile Lys Ala Gly Glu Asp Ile Phe Ser Ile Pro Glu Lys 65 70
75 80 Phe Phe Lys Lys Ala Asp Lys Val Gly Val Lys Val Pro Tyr Ser
Thr 85 90 95 Ala Glu Ile Ile Thr Phe Leu Val Glu His Ala Pro Val
Glu Asp Arg 100 105 110 Leu Ala Lys Arg Asp Phe Val Leu Phe Leu Asp
Ser Lys Asn Lys Leu 115 120 125 Arg Ile Gly Asp Cys Leu Val Ile Glu
Glu Ile Lys Glu Asp 130 135 140 5775PRTPyrococcus furiosus 57Met
Pro Ile Thr Lys Val Thr Arg Asn Tyr Gln Ile Thr Ile Pro Ala 1 5 10
15 Glu Ile Arg Lys Ala Leu Gly Ile Lys Glu Gly Glu Leu Leu Glu Val
20 25 30 Arg Leu Glu Asn Gly Lys Ile Ile Ile Glu Arg Leu Lys Lys
Glu Arg 35 40 45 Lys Thr Leu Lys Leu Gly Lys Lys Leu Thr Leu Glu
Glu Ile Glu Lys 50 55 60 Ala Ile Glu Glu Gly Met Lys Gln Cys Met
Gln 65 70 75 5876PRTPyrococcus furiosus 58Thr Lys Ile Glu Ile Leu
Arg Leu Leu Lys Glu Arg Glu Met Tyr Ala 1 5 10 15 Tyr Glu Ile Trp
Ser Leu Leu Gly Lys Pro Leu Lys Tyr Gln Ala Val 20 25 30 His Gln
His Ile Lys Glu Leu Leu Glu Leu Gly Leu Val Glu Gln Ala 35 40 45
Tyr Arg Lys Gly Lys Arg Val Tyr Tyr Lys Ile Thr Glu Lys Gly Leu 50
55 60 Arg Ile Leu Gln Asn Phe Glu Asp Leu Glu Asn Ile 65 70 75
5972PRTPyrococcus furiosus 59Met Asn Thr Gly Ala Gln Gly Val Ser
Glu Met Ser Arg Met Lys Ile 1 5 10 15 Ile Ser Val Gln Leu Pro Gln
Ser Leu Ile His Gly Leu Asp Ala Leu 20 25 30 Val Lys Arg Gly Ile
Tyr Pro Asn Arg Ser Glu Ala Ile Arg Val Ala 35 40 45 Ile Arg Glu
Leu Leu Lys Lys Glu Leu Tyr Lys Glu Glu Ile Gln Glu 50 55 60 Glu
Ile Pro Glu Tyr Val Val Lys 65 70 6067PRTPyrococcus furiosus 60Val
Ile Ile Pro Arg Pro Ile Asp Pro Arg Asp Ile Arg Arg Ile Arg 1 5 10
15 Lys Glu Leu Gly Ile Thr Gln Glu Glu Leu Ala Arg Lys Ala Gly Val
20 25 30 Thr Gln Ala Tyr Ile Ala Lys Leu Glu Ala Gly Lys Val Asp
Pro Arg 35 40 45 Leu Ser Thr Phe Asn Lys Ile Leu Arg Ala Leu Ile
Glu Cys Gln Lys 50 55 60 Ala Lys Ile 65 6165PRTPyrococcus furiosus
61Asn Asn Cys Glu Cys Met Val Val Lys Glu Lys Leu Tyr Thr Val Lys 1
5 10 15 Gln Ala Ser Glu Ile Leu Gly Val His Pro Lys Thr Ile Gln Lys
Trp 20 25 30 Asp Arg Glu Gly Lys Ile Lys Thr Val Arg Thr Pro Gly
Gly Arg Arg 35 40 45 Arg Ile Pro Glu Ser Glu Ile Lys Arg Leu Leu
Gly Ile Ser Glu Glu 50 55 60 Lys 65 6271PRTPyrococcus furiosus
62Met Leu Lys Asp Ser Ala Pro Lys Arg Lys Ile Leu Glu Glu Leu Arg 1
5 10 15 Lys Gly Glu Thr Val Ser Gly Asp Tyr Leu Ala Ser Lys Leu Gly
Val 20 25 30 Ser Arg Val Ala Ile Trp Lys His Ile Arg Glu Leu Lys
Glu Leu Gly 35 40 45 Tyr Gly Ile Ile Ala Asp Lys Lys Gly Tyr Lys
Leu Val Tyr Glu Pro 50 55 60 Lys Lys Pro Tyr Pro Trp Glu 65 70
6386PRTPyrococcus furiosus 63Met Ile Asp Glu Arg Asp Lys Ile Ile
Leu Glu Ile Leu Glu Lys Asp 1 5 10 15 Ala Arg Thr Pro Phe Thr Glu
Ile Ala Lys Lys Leu Gly Ile Ser Glu 20 25 30 Thr Ala Val Arg Lys
Arg Val Lys Ala Leu Glu Glu Lys Gly Ile Ile 35 40 45 Glu Gly Tyr
Thr Ile Lys Ile Asn Pro Lys Lys Leu Gly Tyr Ser Leu 50 55 60 Val
Thr Ile Thr Gly Val Asp Thr Lys Pro Glu Lys Leu Phe Glu Val 65 70
75 80 Ala Glu Lys Leu Lys Glu 85 6477PRTPyrococcus furiosus 64Met
Glu Ile Asp Asp Leu Asp Arg Lys Ile Leu Ser Leu Leu Ile Glu 1 5 10
15 Asp Ser Arg Leu Ser Tyr Arg Glu Ile Ala Lys Lys Leu Asn Val Ala
20 25 30 Val Gly Thr Ile Tyr Asn Arg Ile Lys Lys Leu Glu Asp Met
Gly Val 35 40 45 Ile Gln Gly Phe Thr Val Lys Leu Asn Tyr Glu Lys
Leu Gly Tyr Glu 50 55 60 Leu Thr Ala Ile Ile Gly Ile Lys Ala Gln
Gly Lys Lys 65 70 75 6594PRTPyrococcus furiosus 65Glu Met Leu Trp
Met Tyr Ile Leu Lys Leu Leu Lys Asp Arg Pro Met 1 5 10 15 Tyr Ala
Tyr Glu Ile Arg Asn Glu Leu Lys Lys Arg Phe Gly Phe Glu 20 25 30
Pro Ala Thr Val Ser Ser Tyr Val Val Leu Tyr Arg Leu Glu Glu Gly 35
40 45 Gly Tyr Val Ser Ser Glu Trp His Glu Ser Glu Ala Gly Arg Pro
Ser 50 55 60 Arg Lys Tyr Tyr Arg Leu Thr Glu Lys Gly Glu Lys Leu
Leu Glu Lys 65 70 75 80 Gly Ile Glu Thr Ile Glu Asp Val Leu Asn Met
Leu Lys Ser 85 90 6668PRTPyrococcus furiosus 66Met Lys Val Ser Lys
Ala Thr Ala Ser Lys Val Leu Arg Ser Leu Glu 1 5 10 15 Asn Lys Gly
Ile Val Glu Arg Glu Arg Arg Gly Lys Thr Tyr Leu Val 20 25 30 Arg
Leu Thr Asn Lys Gly Leu Glu Leu Leu Glu Glu Ile Ser Lys Ala 35 40
45 Gly Lys Glu Leu Asp Glu Lys Ile Phe Ala Glu Met Ser Val Asp Glu
50 55 60 Arg Ile Val Leu 65 6756PRTPyrococcus furiosus 67Ser Glu
Asp Tyr Met Leu Gln Asn Arg Arg Lys Val Leu Ala Lys Val 1 5 10 15
Leu Glu Leu Leu Asn Tyr Asn Pro Lys Ala Leu Asn Ile Ser Glu Leu 20
25 30 Ala Arg Met Phe Gly Val Ser Arg Asp Thr Ile Tyr Asn Asp Ile
Gln 35 40 45 Gln Ile Ile Lys Asn Val Glu Val 50 55
6894PRTPyrococcus furiosus 68Ser Lys Glu Ile Ser Arg Phe Leu Lys
Val Ile Ser Asn Pro Ile Arg 1 5 10 15 Tyr Gly Ile Leu Lys Met Leu
Asn Asp Arg Trp Met Cys Val Cys Leu 20 25 30 Ile Ser Glu Ala Leu
Glu Ile Asp Gln Thr Leu Val Ser His His Ile 35 40 45 Arg Ile Leu
Lys Glu Leu Asp Leu Leu Glu Glu Arg Lys Glu Gly Lys 50 55 60 Leu
Arg Phe Tyr Arg Thr Asn Lys Glu Lys Leu Arg Glu Tyr Leu Glu 65 70
75 80 Lys Val Leu Glu Asp Phe Asn His Gly Thr Ser Lys Gly Ser 85 90
6978PRTPyrococcus furiosus 69Met Cys Arg Lys Asp Val Met Ile Ile
Ser Asp Pro Lys Gln Ile Lys 1 5 10 15 Ala Leu Ser Asp Pro Thr Arg
Val Lys Ile Leu Glu Leu Leu Arg Tyr 20 25 30 His Pro Met Thr Val
Ser Glu Ile Ser Arg Val Ile Gly Lys Asp Lys 35 40 45 Ser Thr Ile
Tyr Arg His Ile Lys Ala Leu Glu Glu Ala Gly Leu Val 50 55 60 Glu
Glu Val Glu Lys Ile Gly Asn Glu Thr Val Tyr Gly Arg 65 70 75
70122PRTPyrococcus furiosus 70Met Glu Pro Val Glu Phe Lys Leu Asn
Gln Lys Gly Ile Lys Ser Ile 1 5 10 15 Leu Pro Thr Met Glu Ala Glu
Ile Met Glu Tyr Met Trp Glu Ile Lys 20 25 30 Glu Ala Thr Ala Gly
Glu Val Tyr Glu Tyr Met Lys Thr Lys Tyr Pro 35 40 45 Glu Ile Arg
Arg Ser Thr Val Ser Ile Leu Met Asn Arg Leu Cys Glu 50 55 60 Arg
Gly Leu Leu Lys Arg Arg Met Glu Lys Gly Lys Gly Gly Ile Arg 65 70
75 80 Tyr Val Tyr Ser Ile Thr Thr Thr Arg Glu Glu Phe Glu Arg Lys
Val 85 90 95 Val Glu Lys Ile Ile Glu Ser Leu Met Met Asn Phe Arg
Glu Ala Thr 100 105 110 Phe Ala Tyr Leu Ser Lys Ile Asn Lys Lys 115
120 7187PRTPyrococcus furiosus 71Met Lys Lys Ser Asn Leu Asp Leu
Leu Ile Leu Leu Ala Lys Ala Gly 1 5 10 15 Gly Ile Glu Lys Glu Ile
Leu Thr Thr Ser Arg Glu Leu Ser Lys Met 20 25 30 Leu Asn Val Ser
Pro Gln Thr Ile Val Arg Trp Leu Glu Asp Leu Glu 35 40 45 Lys Asp
Gly Leu Ile Lys Lys Ser Glu Ser Arg Lys Gly Thr Leu Val 50 55 60
Thr Ile Thr Glu Glu Gly Val Lys Phe Leu Glu Lys Leu His Glu Glu 65
70 75 80 Leu Ser Asp Ala Leu Tyr Arg 85 72104PRTThermococcaceae
72Met Glu Ile Pro Pro Glu Ile Ser His Ala Leu Ser Glu Ile Gly Phe 1
5 10 15 Thr Lys Tyr Glu Ile Leu Thr Tyr Trp Thr Leu Leu Val Tyr Gly
Pro 20 25 30 Ser Thr Ala Lys Glu Ile Ser Thr Lys Ser Gly Ile Pro
Tyr Asn Arg 35 40 45 Val Tyr Asp Thr Ile Ser Ser Leu Lys Leu Arg
Gly Phe Val Thr Glu 50 55 60 Ile Glu Gly Thr Pro Lys Val Tyr Ala
Ala Tyr Ser Pro Arg Ile Ala 65 70 75 80 Phe Phe Arg Phe Lys Lys Glu
Leu Glu Asp Ile Met Lys Lys Leu Glu 85 90
95 Ile Glu Leu Asn Asn Val Lys Lys 100 7375PRTPyrococcus furiosus
73Ile Ile Asn Pro Gln Ala Arg Leu Thr Pro Leu Glu Leu Glu Ile Leu 1
5 10 15 Glu Ile Ile Lys Gln Lys Lys Ser Ile Thr Ile Thr Glu Ile Lys
Glu 20 25 30 Ile Leu Ser Glu Arg Arg Lys Ser Glu Tyr Pro Leu Ser
Leu Val Ser 35 40 45 Glu Tyr Ile Ser Arg Leu Glu Arg Lys Gly Tyr
Val Lys Lys Ile Ala 50 55 60 Lys Gly Arg Lys Lys Phe Val Glu Ala
Leu Ile 65 70 75 7494PRTPyrococcus furiosus 74Gly Ile Asp Val Val
Ile Pro Glu Ile Lys His Asp Pro Ile Ala Arg 1 5 10 15 Asp Ile Val
Lys Ile Leu Phe Asp Leu Arg Arg Ala Asn Val Ser Gln 20 25 30 Ile
Ala Arg Glu Leu Lys Gly Arg Arg Gly Lys Ala Ser Arg Asn Thr 35 40
45 Val Arg Lys Lys Leu Lys Glu Leu Glu Lys Leu Gly Val Val Lys Glu
50 55 60 Val Pro Gly Glu Arg Gly Ser Val Tyr Thr Leu Ser Arg Glu
Val Val 65 70 75 80 Lys Lys Trp Leu Asp Leu Ile Gly Ile Pro Ile Asn
Leu Leu 85 90 7567PRTPyrococcus furiosus 75Met Thr Lys Arg Val Lys
Val Ile Thr Asp Pro Glu Val Ile Lys Val 1 5 10 15 Met Leu Glu Asp
Thr Arg Arg Lys Ile Leu Gln Leu Leu Arg Asn Arg 20 25 30 Glu Met
Thr Ile Ser Gln Leu Ser Glu Ile Leu Gly Lys Met Pro Gln 35 40 45
Thr Ile Tyr His His Ile Glu Lys Leu Lys Glu Ala Gly Leu Val Glu 50
55 60 Val Lys Arg 65 76100PRTPyrococcus furiosus 76Met Glu Glu Ile
Lys Glu Ile Met Lys Ser His Thr Leu Gly Asn Pro 1 5 10 15 Val Arg
Leu Gly Ile Met Ile Tyr Leu Phe Pro Arg Arg Arg Ala Pro 20 25 30
Phe Ser His Ile Gln Lys Ala Leu Asp Leu Thr Pro Gly Asn Leu Asp 35
40 45 Ser His Ile Lys Val Leu Glu Lys His Gly Phe Val Arg Thr Tyr
Lys 50 55 60 Val Ile Ala Asp Arg Pro Arg Thr Met Val Glu Ile Thr
Asp Tyr Gly 65 70 75 80 Met Glu Glu Thr Arg Lys Phe Leu Ser His Leu
Lys Thr Val Ile Asp 85 90 95 Ala Ile His Phe 100 7799PRTPyrococcus
furiosus 77Met Gly Glu Glu Leu Asn Arg Leu Leu Asp Val Leu Gly Asn
Glu Thr 1 5 10 15 Arg Arg Arg Ile Leu Phe Leu Leu Thr Lys Arg Pro
Tyr Phe Val Ser 20 25 30 Glu Leu Ser Arg Glu Leu Gly Val Gly Gln
Lys Ala Val Leu Glu His 35 40 45 Leu Arg Ile Leu Glu Glu Ala Gly
Leu Ile Glu Ser Arg Val Glu Lys 50 55 60 Ile Pro Arg Gly Arg Pro
Arg Lys Tyr Tyr Met Ile Lys Lys Gly Leu 65 70 75 80 Arg Leu Glu Ile
Leu Leu Thr Pro Thr Leu Phe Gly Ser Glu Met Tyr 85 90 95 Glu Ala
Lys 7861PRTPyrococcus furiosus 78Met Arg Arg Met Asp Lys Val Asp
Leu Gln Leu Ile Lys Ile Leu Ser 1 5 10 15 Gln Asn Ser Arg Leu Thr
Tyr Arg Glu Leu Ala Glu Met Leu Gly Thr 20 25 30 Thr Arg Gln Arg
Val Ala Arg Lys Val Asp Lys Leu Lys Lys Leu Gly 35 40 45 Ile Ile
Arg Lys Phe Thr Ile Ile Pro Asn Leu Glu Lys 50 55 60
7982PRTPyrococcus furiosus 79Gly Arg Lys Val Arg Thr Gln Gln Asn
Glu Ile Leu Asn Leu Leu Asn 1 5 10 15 Glu Lys Glu Lys Ala Val Leu
Arg Ala Ile Leu Glu His Gly Gly Glu 20 25 30 Ile Lys Gln Glu Asp
Leu Pro Glu Leu Val Gly Tyr Ser Arg Pro Thr 35 40 45 Ile Ser Lys
Val Ile Gln Glu Leu Glu Asn Lys Gly Leu Ile Lys Arg 50 55 60 Glu
Lys Ser Gly Lys Thr Phe Val Val Lys Ile Glu Arg Lys Ile Lys 65 70
75 80 Leu Asp 8059PRTThermotoga maritima 80Lys Ser Leu Gln Arg Phe
Leu Arg Arg Asn Thr Thr Ser Ile Lys His 1 5 10 15 Leu Ser Glu Ile
Thr Gly Val Ala Arg Asn Arg Leu Ser Asp Ile Leu 20 25 30 Asn Gly
Lys Thr Gln Lys Ile Arg Gly Glu Thr Leu Arg Lys Ile Ala 35 40 45
Lys Ala Phe Glu Lys Ser Asn Ile Leu Ser Phe 50 55
81107PRTThermotoga 81Asp Val Ile Gln Arg Ile Lys Glu Lys Tyr Asp
Glu Phe Thr Asn Ala 1 5 10 15 Glu Lys Lys Ile Ala Asp Thr Ile Leu
Ser Asp Pro Lys Gly Ile Ile 20 25 30 Glu Ser Ser Ile Ser Asp Leu
Ser Glu Lys Ala Gly Val Lys Ser Glu 35 40 45 Ala Ser Val Val Lys
Phe Tyr Lys Lys Leu Gly Leu Asn Ser Phe Gln 50 55 60 Gln Phe Lys
Val Leu Leu Ala Gln Ser Ile Ser Arg Ala Pro Leu Glu 65 70 75 80 Ile
Val Tyr Glu Asp Val Ser Ser Glu Asp Asp Thr Lys Thr Ile Thr 85 90
95 Glu Lys Ile Phe Lys Ala Thr Val Arg Ala Ile 100 105
82101PRTThermotoga maritima 82Lys Ile Arg Asp Lys Ile Leu Asn Val
Tyr Thr Gln Phe Ser Pro Ala 1 5 10 15 Glu Arg Lys Val Ala Asp Tyr
Val Leu Glu Arg Pro Asp Asp Val Ile 20 25 30 His Tyr Ser Ile Thr
Glu Phe Ala Lys Ile Val Gly Val Ser Glu Thr 35 40 45 Thr Ile His
Arg Met Ile Lys Lys Leu Asp Phe Glu Gly Tyr Gln Ala 50 55 60 Phe
Lys Ile Ala Leu Ala Arg Glu Leu Ser Gly Leu Glu Glu Thr Ile 65 70
75 80 Glu Arg Arg Asp Phe Ile Asp Glu Glu Ile Asp Ile Leu Arg Arg
Leu 85 90 95 Lys Asp Thr Leu Asp 100 8360PRTThermotoga maritima
83Lys Arg Arg Pro Thr Ile Asn Asp Val Ala Lys Leu Ala Gly Val Ser 1
5 10 15 Ile Ser Thr Val Ser Arg Tyr Leu Lys Asp Pro Ser Gln Val Ser
Glu 20 25 30 Lys Leu Gly Glu Arg Ile Arg Glu Ala Ile Lys Lys Leu
Gly Tyr Lys 35 40 45 Pro Asn Lys Ile Ala Gln Gly Leu Arg Thr Gly
Asp 50 55 60 8458PRTThermotoga maritima 84Met Ala Ser Ile Lys Asp
Val Ala Lys Leu Ala Gly Val Ser Ile Ala 1 5 10 15 Thr Val Ser Arg
Val Ile Asn Gly Tyr Asn Asn Val Ser Glu Glu Thr 20 25 30 Arg Lys
Lys Val Ile Asp Ala Ile Arg Lys Leu Asn Tyr His Pro Val 35 40 45
Tyr Ala Val Lys Gly Ala Val Leu Lys Arg 50 55 8561PRTThermotoga
maritima 85Met Lys Lys Lys Tyr Val Thr Ile Arg Asp Ile Ala Glu Lys
Ala Gly 1 5 10 15 Val Ser Ile Asn Thr Val Ser Arg Ala Leu Asn Asn
Lys Pro Asp Ile 20 25 30 Ser Glu Glu Thr Arg Arg Lys Ile Leu Lys
Ile Ala Gln Glu Leu Gly 35 40 45 Tyr Val Lys Asn Ala Thr Ala Ser
Ser Leu Arg Ser Lys 50 55 60 8658PRTThermotoga 86Met Pro Thr Ile
Glu Asp Val Ala Lys Leu Ala Gly Val Ser Ile Ala 1 5 10 15 Thr Val
Ser Arg Val Ile Asn Gly Ser Gly Tyr Val Ser Glu Lys Thr 20 25 30
Arg Tyr Lys Val Trp Lys Ala Ile Glu Glu Leu Gly Tyr Lys Pro Glu 35
40 45 Ile Ser Ala Lys Leu Leu Ala Ser Lys Gly 50 55
8761PRTThermotoga maritima 87Met Arg Ile Gly Glu Lys Leu Arg Lys
Leu Arg Leu Ser Arg Gly Leu 1 5 10 15 Thr Gln Glu Glu Leu Ala Glu
Arg Thr Asp Leu Ser Arg Ser Phe Ile 20 25 30 Ser Gln Leu Glu Ser
Asp Lys Thr Ser Pro Ser Ile Asp Thr Leu Glu 35 40 45 Arg Ile Leu
Glu Ala Leu Gly Thr Asp Leu Lys His Phe 50 55 60 8867PRTThermotoga
maritima 88Met His Met Lys Thr Val Arg Gln Glu Arg Leu Lys Ser Ile
Val Arg 1 5 10 15 Ile Leu Glu Arg Ser Lys Glu Pro Val Ser Gly Ala
Gln Leu Ala Glu 20 25 30 Glu Leu Ser Val Ser Arg Gln Val Ile Val
Gln Asp Ile Ala Tyr Leu 35 40 45 Arg Ser Leu Gly Tyr Asn Ile Val
Ala Thr Pro Arg Gly Tyr Val Leu 50 55 60 Ala Gly Gly 65
8975PRTThermotoga maritima 89Met Asn Thr Leu Lys Lys Ala Phe Glu
Ile Leu Asp Phe Ile Val Lys 1 5 10 15 Asn Pro Gly Asp Val Ser Val
Ser Glu Ile Ala Glu Lys Phe Asn Met 20 25 30 Ser Val Ser Asn Ala
Tyr Lys Tyr Met Val Val Leu Glu Glu Lys Gly 35 40 45 Phe Val Leu
Arg Lys Lys Asp Lys Arg Tyr Val Pro Gly Tyr Lys Leu 50 55 60 Ile
Glu Tyr Gly Ser Phe Val Leu Arg Arg Phe 65 70 75 9081PRTThermotoga
maritima 90Met Lys Ile Ser Lys Lys Arg Arg Gln Glu Leu Ile Arg Lys
Ile Ile 1 5 10 15 His Glu Lys Lys Ile Ser Asn Gln Phe Gln Ile Val
Glu Glu Leu Lys 20 25 30 Lys Tyr Gly Ile Lys Ala Val Gln Pro Thr
Val Ala Arg Asp Leu Lys 35 40 45 Glu Ile Gly Ala Val Lys Ile Met
Asp Glu Ser Gly Asn Tyr Val Tyr 50 55 60 Lys Leu Leu Asp Glu Thr
Pro Val Ile Asp Pro Trp Lys Glu Leu Lys 65 70 75 80 Arg
9182PRTThermotoga maritima 91Met His Lys Lys Leu Asn Pro Lys Ser
Met Lys Arg Glu Asn Lys Lys 1 5 10 15 Met Val Leu Arg Tyr Leu Ile
Glu Ser Gly Pro His Ser Arg Val Glu 20 25 30 Ile Ala Arg Lys Thr
Gly Leu Ala Gln Ser Ala Ile Trp Arg Ile Ile 35 40 45 Glu Glu Leu
Val Asn Glu Gly Leu Val Glu Glu Lys Gly Thr Ala Thr 50 55 60 Gly
Arg Arg Arg Lys Ala Val Thr Tyr Gly Pro Thr Arg Ser Phe Ile 65 70
75 80 Thr Ser 9279PRTThermotoga maritima 92Met Pro Ser Pro Leu Leu
Arg Arg Glu Asn Lys Ile Lys Ile Leu Arg 1 5 10 15 Tyr Ile Leu Lys
Asn Gly Lys Thr Thr Arg Asn Gln Leu Ala Ser Asn 20 25 30 Leu Asn
Leu Ala His Ser Thr Leu Ser Tyr Ile Ile Asp Glu Leu Leu 35 40 45
Asp Glu Gly Phe Leu Val Phe Glu Glu Ile Lys Lys Lys Arg Gly Arg 50
55 60 Pro Tyr Gln Ile Leu Ser Val Asn Pro Glu Lys Phe Thr Ala Ile
65 70 75 9379PRTThermotoga maritima 93Met Lys Glu Glu Arg Leu Lys
Glu Ile Leu Asp Ile Val Asp Arg Asn 1 5 10 15 Gly Phe Ile Ser Met
Lys Asp Leu Gln Glu Gln Leu Gly Val Ser Met 20 25 30 Ile Thr Val
Arg Arg Asp Val Ala Glu Leu Val Lys Arg Asn Leu Val 35 40 45 Lys
Lys Val His Gly Gly Ile Arg Lys Val Asn Tyr Phe Glu Lys Glu 50 55
60 Thr Asp Phe Met Lys Arg Leu Ser Ile Asn Arg Glu Ala Lys Glu 65
70 75 94137PRTThermotoga maritima 94Met Phe Thr Met Arg Ser Glu Tyr
Ala Leu Arg Leu Met Ile Val Met 1 5 10 15 Ala Lys Glu Tyr Gly Asn
Tyr Leu Ser Met Thr Glu Ile Leu Glu Lys 20 25 30 Ala Lys Gln Ser
Val Pro Arg Glu Phe Ala Glu Lys Ile Leu Tyr Thr 35 40 45 Leu Lys
Lys Ala Gly Leu Val Lys Thr Arg Arg Gly Lys Ser Gly Gly 50 55 60
Tyr Met Leu Ser Arg Pro Pro Lys Glu Ile Lys Val Ser Glu Ile Val 65
70 75 80 Phe Leu Leu Asp Arg Lys Ser Lys Val Phe Phe Asp Met Pro
Gly Cys 85 90 95 Pro Asp Glu Leu Asp Cys Val Ile Arg Ala Leu Trp
Lys Arg Val Glu 100 105 110 Asn Glu Ile Glu Lys Ile Leu Ser Gly Val
Thr Leu Glu Asp Leu Val 115 120 125 Arg Glu Gln Glu Glu Lys Met Lys
Gln 130 135 9595PRTThermotoga naphthophila 95Met Arg Asp Thr Lys
Gly His Leu Lys Phe Leu Val Leu His Ile Ile 1 5 10 15 Ser Gln Gln
Pro Ser His Gly Tyr Tyr Ile Met Lys Lys Ile Ser Gln 20 25 30 Ile
Ile Gly Ala Glu Pro Pro Ser Pro Gly Ala Leu Tyr Pro Ile Leu 35 40
45 Ser Ser Leu Arg Lys Gln Lys Tyr Ile Glu Thr Tyr Asn Glu Gly Lys
50 55 60 Arg Lys Val Tyr Arg Leu Thr Asp Lys Gly Arg Lys Tyr Leu
Glu Glu 65 70 75 80 His Lys Glu Glu Ile Lys Lys Ala Leu Asp Phe Ala
Glu Arg Phe 85 90 95 96118PRTThermotoga maritima 96Met Arg His Arg
Gly Gly Arg Gly Phe Arg Gly Trp Trp Leu Ala Ser 1 5 10 15 Thr Ile
Leu Leu Leu Val Ala Glu Lys Pro Ser His Gly Tyr Glu Leu 20 25 30
Ala Glu Arg Leu Ala Glu Phe Gly Ile Glu Ile Pro Gly Ile Gly His 35
40 45 Met Gly Asn Ile Tyr Arg Val Leu Ala Asp Leu Glu Glu Ser Gly
Phe 50 55 60 Leu Ser Thr Glu Trp Asp Thr Thr Val Ser Pro Pro Arg
Lys Ile Tyr 65 70 75 80 Arg Ile Thr Pro Gln Gly Lys Leu Tyr Leu Arg
Glu Ile Leu Arg Ser 85 90 95 Leu Glu Asp Met Lys Arg Arg Ile Glu
Thr Leu Glu Glu Arg Ile Lys 100 105 110 Arg Val Leu Gln Glu Glu 115
9770PRTThermotoga maritima 97Met Leu Ser Lys Arg Asp Ala Ile Leu
Lys Ala Ala Val Glu Val Phe 1 5 10 15 Gly Lys Lys Gly Tyr Asp Arg
Ala Thr Thr Asp Glu Ile Ala Glu Lys 20 25 30 Ala Gly Val Ala Lys
Gly Leu Ile Phe His Tyr Phe Lys Asn Lys Glu 35 40 45 Glu Leu Tyr
Tyr Gln Ala Tyr Met Ser Val Thr Glu Lys Leu Gln Lys 50 55 60 Glu
Phe Glu Asn Phe Leu 65 70 98291PRTArtificial SequenceSynthetic
construct 98Met Ser Lys Ser Trp Gly Lys Phe Ile Glu Glu Glu Glu Ala
Glu Met 1 5 10 15 Ala Ser Arg Arg Asn Leu Met Ile Val Asp Gly Thr
Asn Leu Gly Phe 20 25 30 Arg Phe Lys His Asn Asn Ser Lys Lys Pro
Phe Ala Ser Ser Tyr Val 35 40 45 Ser Thr Ile Gln Ser Leu Ala Lys
Ser Tyr Ser Ala Arg Thr Thr Ile 50 55 60 Val Leu Gly Asp Lys Gly
Lys Ser Val Phe Arg Leu Glu His Leu Pro 65 70 75 80 Glu Tyr Lys Gly
Asn Arg Asp Glu Lys Tyr Ala Gln Arg Thr Glu Glu 85 90 95 Glu Lys
Ala Leu Asp Glu Gln Phe Phe Glu Tyr Leu Lys Asp Ala Phe 100 105 110
Glu Leu Cys Lys Thr Thr Phe Pro Thr Phe Thr Ile Arg Gly Val Glu 115
120 125 Ala Asp Asp Met Ala Ala Tyr Ile Val Lys Leu Ile Gly His Leu
Tyr 130 135 140 Asp His Val Trp Leu Ile Ser Thr Asp Gly Asp Trp Asp
Thr Leu Leu 145 150 155 160 Thr Asp Lys Val Ser Arg Phe Ser Phe Thr
Thr
Arg Arg Glu Tyr His 165 170 175 Leu Arg Asp Met Tyr Glu His His Asn
Val Asp Asp Val Glu Gln Phe 180 185 190 Ile Ser Leu Lys Ala Ile Met
Gly Asp Leu Gly Asp Asn Ile Arg Gly 195 200 205 Val Glu Gly Ile Gly
Ala Lys Arg Gly Tyr Asn Ile Ile Arg Glu Phe 210 215 220 Gly Asn Val
Leu Asp Ile Ile Asp Gln Leu Pro Leu Pro Gly Lys Gln 225 230 235 240
Lys Tyr Ile Gln Asn Leu Asn Ala Ser Glu Glu Leu Leu Phe Arg Asn 245
250 255 Leu Ile Leu Val Asp Leu Pro Thr Tyr Cys Val Asp Ala Ile Ala
Ala 260 265 270 Val Gly Gln Asp Val Leu Asp Lys Phe Thr Lys Asp Ile
Leu Glu Ile 275 280 285 Ala Glu Gln 290 9953DNAArtificial
SequenceSynthetic constructmisc_feature(17)..(37)n is a, c, g, or t
99tttctagctc taaaacnnnn nnnnnnnnnn nnnnnnncgg tgtttcgtcc ttt
53100148PRTSulfolobus solfataricus 100Met Glu Glu Lys Val Gly Asn
Leu Lys Pro Asn Met Glu Ser Val Asn 1 5 10 15 Val Thr Val Arg Val
Leu Glu Ala Ser Glu Ala Arg Gln Ile Gln Thr 20 25 30 Lys Asn Gly
Val Arg Thr Ile Ser Glu Ala Ile Val Gly Asp Glu Thr 35 40 45 Gly
Arg Val Lys Leu Thr Leu Trp Gly Lys His Ala Gly Ser Ile Lys 50 55
60 Glu Gly Gln Val Val Lys Ile Glu Asn Ala Trp Thr Thr Ala Phe Lys
65 70 75 80 Gly Gln Val Gln Leu Asn Ala Gly Ser Lys Thr Lys Ile Ala
Glu Ala 85 90 95 Ser Glu Asp Gly Phe Pro Glu Ser Ser Gln Ile Pro
Glu Asn Thr Pro 100 105 110 Thr Ala Pro Gln Gln Met Arg Gly Gly Gly
Arg Gly Phe Arg Gly Gly 115 120 125 Gly Arg Arg Tyr Gly Arg Arg Gly
Gly Arg Arg Gln Glu Asn Glu Glu 130 135 140 Gly Glu Glu Glu 145
101673PRTThermus thermophilus 101Met Thr Leu Glu Glu Ala Arg Lys
Arg Val Asn Glu Leu Arg Asp Leu 1 5 10 15 Ile Arg Tyr His Asn Tyr
Arg Tyr Tyr Val Leu Ala Asp Pro Ile Ser 20 25 30 Asp Ala Glu Tyr
Asp Arg Leu Leu Arg Glu Leu Lys Glu Leu Glu Glu 35 40 45 Arg Phe
Pro Glu Leu Lys Ser Pro Asp Ser Pro Thr Leu Gln Val Gly 50 55 60
Ala Arg Pro Leu Glu Ala Thr Phe Arg Pro Val Arg His Pro Thr Arg 65
70 75 80 Met Tyr Ser Leu Asp Asn Ala Phe Asn Leu Asp Glu Leu Lys
Ala Phe 85 90 95 Glu Glu Arg Ile Glu Arg Ala Leu Gly Arg Lys Gly
Pro Phe Ala Tyr 100 105 110 Thr Val Glu His Lys Val Asp Gly Leu Ser
Val Asn Leu Tyr Tyr Glu 115 120 125 Glu Gly Val Leu Val Tyr Gly Ala
Thr Arg Gly Asp Gly Glu Val Gly 130 135 140 Glu Glu Val Thr Gln Asn
Leu Leu Thr Ile Pro Thr Ile Pro Arg Arg 145 150 155 160 Leu Lys Gly
Val Pro Glu Arg Leu Glu Val Arg Gly Glu Met Pro Ile 165 170 175 Glu
Ala Phe Leu Arg Leu Asn Glu Glu Leu Glu Glu Arg Gly Glu Arg 180 185
190 Ile Phe Lys Asn Pro Arg Asn Ala Ala Ala Gly Ser Leu Arg Gln Lys
195 200 205 Asp Pro Arg Ile Thr Ala Lys Arg Gly Leu Arg Ala Thr Phe
Tyr Ala 210 215 220 Leu Gly Leu Gly Leu Glu Glu Val Glu Arg Glu Gly
Val Ala Thr Gln 225 230 235 240 Phe Ala Leu Leu His Trp Leu Lys Glu
Lys Gly Phe Pro Val Glu His 245 250 255 Gly Tyr Ala Arg Ala Val Gly
Ala Glu Gly Val Glu Ala Val Tyr Gln 260 265 270 Asp Trp Leu Lys Lys
Arg Arg Ala Leu Pro Phe Glu Ala Asp Gly Val 275 280 285 Val Val Lys
Leu Asp Glu Leu Ala Leu Trp Arg Glu Leu Gly Tyr Thr 290 295 300 Ala
Arg Ala Pro Arg Phe Ala Ile Ala Tyr Lys Phe Pro Ala Glu Glu 305 310
315 320 Lys Glu Thr Arg Leu Leu Asp Val Val Phe Gln Val Gly Arg Thr
Gly 325 330 335 Arg Val Thr Pro Val Gly Ile Leu Glu Pro Val Phe Leu
Glu Gly Ser 340 345 350 Glu Val Ser Arg Val Thr Leu His Asn Glu Ser
Tyr Ile Glu Glu Leu 355 360 365 Asp Ile Arg Ile Gly Asp Trp Val Leu
Val His Lys Ala Gly Gly Val 370 375 380 Ile Pro Glu Val Leu Arg Val
Leu Lys Glu Arg Arg Thr Gly Glu Glu 385 390 395 400 Arg Pro Ile Arg
Trp Pro Glu Thr Cys Pro Glu Cys Gly His Arg Leu 405 410 415 Leu Lys
Glu Gly Lys Val His Arg Cys Pro Asn Pro Leu Cys Pro Ala 420 425 430
Lys Arg Phe Glu Ala Ile Arg His Phe Ala Ser Arg Lys Ala Met Asp 435
440 445 Ile Gln Gly Leu Gly Glu Lys Leu Ile Glu Arg Leu Leu Glu Lys
Gly 450 455 460 Leu Val Lys Asp Val Ala Asp Leu Tyr Arg Leu Arg Lys
Glu Asp Leu 465 470 475 480 Val Gly Leu Glu Arg Met Gly Glu Lys Ser
Ala Gln Asn Leu Leu Arg 485 490 495 Gln Ile Glu Glu Ser Lys Lys Arg
Gly Leu Glu Arg Leu Leu Tyr Ala 500 505 510 Leu Gly Leu Pro Gly Val
Gly Glu Val Leu Ala Arg Asn Leu Ala Ala 515 520 525 Arg Phe Gly Asn
Met Asp Arg Leu Leu Glu Ala Ser Leu Glu Glu Leu 530 535 540 Leu Glu
Val Glu Glu Val Gly Glu Leu Thr Ala Arg Ala Ile Leu Glu 545 550 555
560 Thr Leu Lys Asp Pro Ala Phe Arg Asp Leu Val Arg Arg Leu Lys Glu
565 570 575 Ala Gly Val Glu Met Glu Ala Lys Glu Lys Gly Gly Glu Ala
Leu Lys 580 585 590 Gly Leu Thr Phe Val Ile Thr Gly Glu Leu Ser Arg
Pro Arg Glu Glu 595 600 605 Val Lys Ala Leu Leu Arg Arg Leu Gly Ala
Lys Val Thr Asp Ser Val 610 615 620 Ser Arg Lys Thr Ser Tyr Leu Val
Val Gly Glu Asn Pro Gly Ser Lys 625 630 635 640 Leu Glu Lys Ala Arg
Ala Leu Gly Val Pro Thr Leu Thr Glu Glu Glu 645 650 655 Leu Tyr Arg
Leu Leu Glu Ala Arg Thr Gly Lys Lys Ala Glu Glu Leu 660 665 670 Val
102775PRTArtificial SequenceSynthetic construct 102Met Ile Leu Asp
Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 1 5 10 15 Arg Ile
Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 20 25 30
Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 35
40 45 Asp Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Lys Val Val
Arg 50 55 60 Val Val Asp Val Glu Lys Val Lys Lys Lys Phe Leu Gly
Arg Pro Ile 65 70 75 80 Glu Val Trp Lys Leu Tyr Phe Glu His Pro Gln
Asp Val Pro Ala Ile 85 90 95 Arg Asp Lys Ile Arg Glu His Pro Ala
Val Ile Asp Ile Phe Glu Tyr 100 105 110 Asp Ile Pro Phe Ala Lys Arg
Tyr Leu Ile Asp Lys Gly Leu Ile Pro 115 120 125 Met Glu Gly Asn Glu
Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 130 135 140 Leu Tyr His
Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 145 150 155 160
Ser Tyr Ala Asp Glu Glu Gly Ala Lys Val Ile Thr Trp Lys Lys Val 165
170 175 Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile
Lys 180 185 190 Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val
Ile Ile Thr 195 200 205 Tyr Asn Gly Asp Asn Phe Asp Phe Pro Tyr Leu
Leu Lys Arg Ala Glu 210 215 220 Lys Leu Gly Met Lys Leu Pro Leu Gly
Arg Asp Gly Ser Glu Pro Lys 225 230 235 240 Met Gln Arg Leu Gly Asp
Ser Leu Ala Val Glu Ile Lys Gly Arg Ile 245 250 255 His Phe Asp Leu
Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 260 265 270 Tyr Thr
Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 275 280 285
Lys Val Tyr Pro His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 290
295 300 Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr
Tyr 305 310 315 320 Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln
Leu Ala Arg Leu 325 330 335 Val Gly Gln Pro Leu Trp Asp Val Ser Arg
Ser Ser Thr Gly Asn Leu 340 345 350 Val Glu Trp Tyr Leu Leu Arg Lys
Ala Tyr Glu Arg Asn Glu Leu Ala 355 360 365 Pro Asn Lys Pro Asp Glu
Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 370 375 380 Tyr Glu Gly Gly
Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 385 390 395 400 Ile
Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 405 410
415 His Asn Val Ser Pro Asp Thr Leu Asn Lys Glu Gly Cys Gly Glu Tyr
420 425 430 Asp Val Ala Pro Glu Val Gly His Arg Phe Cys Lys Asp Phe
Pro Gly 435 440 445 Phe Ile Pro Ser Leu Leu Gly Ser Leu Leu Asp Glu
Arg Gln Lys Ile 450 455 460 Lys Arg Arg Met Lys Ala Ser Lys Asp Pro
Ile Glu Arg Lys Leu Leu 465 470 475 480 Asp Tyr Arg Gln Arg Ala Ile
Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 485 490 495 Tyr Tyr Gly Tyr Ala
Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 500 505 510 Ser Val Thr
Ala Trp Gly Arg Glu Tyr Ile Glu Leu Val Arg Arg Glu 515 520 525 Leu
Glu Glu Arg Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly Leu 530 535
540 Tyr Ala Thr Ile Pro Gly Glu Lys Asn Trp Glu Glu Ile Lys Arg Arg
545 550 555 560 Ala Leu Glu Phe Val Asn Tyr Ile Asn Ala Lys Leu Pro
Gly Leu Leu 565 570 575 Glu Leu Glu Tyr Glu Gly Phe Tyr Thr Arg Gly
Phe Phe Val Thr Lys 580 585 590 Lys Lys Tyr Ala Leu Ile Asp Glu Glu
Gly Lys Ile Ile Thr Arg Gly 595 600 605 Leu Glu Ile Val Arg Arg Asp
Trp Ser Glu Ile Ala Lys Glu Thr Gln 610 615 620 Ala Lys Val Leu Glu
Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 625 630 635 640 Val Lys
Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 645 650 655
Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu Asn 660
665 670 Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu
Ala 675 680 685 Ala Arg Gly Ile Lys Val Arg Pro Gly Met Val Ile Gly
Tyr Val Val 690 695 700 Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala
Ile Ala Ala Glu Glu 705 710 715 720 Phe Asp Pro Lys Lys His Lys Tyr
Asp Ala Glu Tyr Tyr Ile Glu Asn 725 730 735 Gln Val Leu Pro Ala Val
Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 740 745 750 Lys Glu Asp Leu
Arg Trp Gln Lys Thr Lys Gln Val Gly Leu Gly Ala 755 760 765 Trp Leu
Lys Val Lys Lys Ser 770 775
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