U.S. patent application number 15/617833 was filed with the patent office on 2018-05-03 for single-chain multivalent binding proteins with effector function. This patent application is currently assigned to APTEVO RESEARCH AND DEVELOPMENT LLC. The applicant listed for this patent is APTEVO RESEARCH AND DEVELOPMENT LLC. Invention is credited to Robert BADER, William BRADY, Laura Sue GROSMAIRE, Martha Susan HAYDEN-LEDBETTER, Jeffrey A. LEDBETTER, Peter Armstrong THOMPSON.
Application Number | 20180118823 15/617833 |
Document ID | / |
Family ID | 38832805 |
Filed Date | 2018-05-03 |
United States Patent Application | 20180118823 |
Kind Code | A1 |
THOMPSON; Peter Armstrong ; et al. | May 3, 2018 |
Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin effector function are provided, along with encoding nucleic acids, vectors and host cells as well as methods for making such peptides and methods for using such peptides to treat or prevent a variety of diseases, disorders or conditions, as well as to ameliorate at least one symptom associated with such a disease, disorder or condition.
Inventors: | THOMPSON; Peter Armstrong; (Bellevue, WA) ; LEDBETTER; Jeffrey A.; (Shoreline, WA) ; HAYDEN-LEDBETTER; Martha Susan; (Shoreline, WA) ; GROSMAIRE; Laura Sue; (Hobart, WA) ; BADER; Robert; (Seattle, WA) ; BRADY; William; (Bothell, WA) | ||||||||||
Applicant: |
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Assignee: | APTEVO RESEARCH AND DEVELOPMENT
LLC SEATTLE WA |
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Family ID: | 38832805 | ||||||||||
Appl. No.: | 15/617833 | ||||||||||
Filed: | June 8, 2017 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
13815721 | Mar 15, 2013 | |||
15617833 | ||||
12304562 | Jul 22, 2010 | 8409577 | ||
PCT/US2007/071052 | Jun 12, 2007 | |||
13815721 | ||||
60813261 | Jun 12, 2006 | |||
60853287 | Oct 20, 2006 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | C07K 2317/31 20130101; C07K 16/468 20130101; C07K 2319/30 20130101; A61K 2039/505 20130101; A61K 2039/507 20130101; C07K 16/28 20130101; C07K 2317/52 20130101; C07K 16/2827 20130101; A61P 17/06 20180101; A61P 19/02 20180101; A61P 29/00 20180101; C07K 16/2851 20130101; C07K 16/46 20130101; A61P 1/04 20180101; C07K 2317/64 20130101; A61P 31/00 20180101; A61P 37/06 20180101; C07K 16/2833 20130101; C07K 16/2887 20130101; C07K 16/2803 20130101; C07K 16/2809 20130101; C07K 2317/732 20130101; A61P 25/04 20180101; C07K 2317/734 20130101; C07K 2317/34 20130101; A61P 37/02 20180101; C07K 2317/53 20130101; C07K 2317/622 20130101; C07K 16/18 20130101; C07K 16/2818 20130101; A61P 3/10 20180101; A61P 35/00 20180101; C07K 16/2896 20130101; A61P 31/22 20180101; C07K 16/30 20130101; A61P 11/06 20180101; C07K 16/2875 20130101; A61P 25/00 20180101; A61P 37/00 20180101; A61P 43/00 20180101; C07K 2317/24 20130101; A61P 31/12 20180101; C07K 16/2878 20130101 |
International Class: | C07K 16/28 20060101 C07K016/28; C07K 16/46 20060101 C07K016/46; C07K 16/18 20060101 C07K016/18; C07K 16/30 20060101 C07K016/30 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 417 <210> SEQ ID NO 1 <211> LENGTH: 795
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polynucleotide - anti-CD20 (2H7) LH (DNA) <400> SEQUENCE: 1
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcc
60 agaggacaaa ttgttctctc ccagtctcca gcaatcctgt ctgcatctcc
aggggagaag 120 gtcacaatga cttgcagggc cagctcaagt gtaagttaca
tgcactggta ccagcagaag 180 ccaggatcct cccccaaacc ctggatttat
gccccatcca acctggcttc tggagtccct 240 gctcgcttca gtggcagtgg
gtctgggacc tcttactctc tcacaatcag cagagtggag 300 gctgaagatg
ctgccactta ttactgccag cagtggagtt ttaacccacc cacgttcggt 360
gctgggacca agctggagct gaaagatggc ggtggctcgg gcggtggtgg atctggagga
420 ggtgggagct ctcaggctta tctacagcag tctggggctg agtcggtgag
gcctggggcc 480 tcagtgaaga tgtcctgcaa ggcttctggc tacacattta
ccagttacaa tatgcactgg 540 gtaaagcaga cacctagaca gggcctggaa
tggattggag ctatttatcc aggaaatggt 600 gatacttcct acaatcagaa
gttcaagggc aaggccacac tgactgtaga caaatcctcc 660 agcacagcct
acatgcagct cagcagcctg acatctgaag actctgcggt ctatttctgt 720
gcaagagtgg tgtactatag taactcttac tggtacttcg atgtctgggg cacagggacc
780 acggtcaccg tctct 795 <210> SEQ ID NO 2 <211>
LENGTH: 265 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide - anti-CD20 (2H7) LH (AA) <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1)..(22) <223> OTHER INFORMATION: Leader <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(128) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <400>
SEQUENCE: 2 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser
Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln
Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly Glu Lys Val Thr
Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser Tyr Met His Trp
Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys Pro Trp Ile Tyr
Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80 Ala Arg Phe Ser
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85 90 95 Ser Arg
Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 100 105 110
Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 115
120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg
Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys Lys Ala Ser Gly
Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp Val Lys Gln Thr
Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala Ile Tyr Pro Gly
Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205 Lys Gly Lys Ala
Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210 215 220 Met Gln
Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 225 230 235
240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp
245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser 260 265 <210>
SEQ ID NO 3 <211> LENGTH: 813 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polynucleotide - anti-CD28
(2e12) LH (DNA) <400> SEQUENCE: 3 atggattttc aagtgcagat
tttcagcttc ctgctaatca gtgcttcagt cataatgtcc 60 agaggagtcg
acattgtgct cacccaatct ccagcttctt tggctgtgtc tctaggtcag 120
agagccacca tctcctgcag agccagtgaa agtgttgaat attatgtcac aagtttaatg
180 cagtggtacc aacagaaacc aggacagcca cccaaactcc tcatctctgc
tgctagcaac 240 gtagaatctg gggtccctgc caggtttagt ggcagtgggt
ctgggacaga ctttagcctc 300 aacatccatc ctgtggagga ggatgatatt
gcaatgtatt tctgtcagca aagtaggaag 360 gttccatgga cgttcggtgg
aggcaccaag ctggaaatca aacggggtgg cggtggatcc 420 ggcggaggtg
ggtcgggtgg cggcggatct caggtgcagc tgaaggagtc aggacctggc 480
ctggtggcgc cctcacagag cctgtccatc acatgcaccg tctcagggtt ctcattaacc
540 ggctatggtg taaactgggt tcgccagcct ccaggaaagg gtctggagtg
gctgggaatg 600 atatggggtg atggaagcac agactataat tcagctctca
aatccagact atcgatcacc 660 aaggacaact ccaagagcca agttttctta
aaaatgaaca gtctgcaaac tgatgacaca 720 gccagatact actgtgcccg
agatggttat agtaactttc attactatgt tatggactac 780 tggggtcaag
gaacctcagt caccgtctcc tct 813 <210> SEQ ID NO 4 <211>
LENGTH: 271 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polypeptide - anti-CD28 (2e12) LH (AA) <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1)..(23) <223> OTHER INFORMATION: Leader <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(24)..(135) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(136)..(150) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(151)..(271) <223> OTHER INFORMATION: VH <400>
SEQUENCE: 4 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser
Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Val Asp Ile Val Leu Thr
Gln Ser Pro Ala 20 25 30 Ser Leu Ala Val Ser Leu Gly Gln Arg Ala
Thr Ile Ser Cys Arg Ala 35 40 45 Ser Glu Ser Val Glu Tyr Tyr Val
Thr Ser Leu Met Gln Trp Tyr Gln 50 55 60 Gln Lys Pro Gly Gln Pro
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 65 70 75 80 Val Glu Ser Gly
Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 85 90 95 Asp Phe
Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met 100 105 110
Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly 115
120 125 Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly
Gly 130 135 140 Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser
Gly Pro Gly 145 150 155 160 Leu Val Ala Pro Ser Gln Ser Leu Ser Ile
Thr Cys Thr Val Ser Gly 165 170 175 Phe Ser Leu Thr Gly Tyr Gly Val
Asn Trp Val Arg Gln Pro Pro Gly 180 185 190 Lys Gly Leu Glu Trp Leu
Gly Met Ile Trp Gly Asp Gly Ser Thr Asp 195 200 205 Tyr Asn Ser Ala
Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser 210 215 220 Lys Ser
Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 225 230 235
240 Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr
245 250 255 Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser
Ser 260 265 270 <210> SEQ ID NO 5 <211> LENGTH: 828
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polynucleotide - anti-CD28 (2e12) HL (DNA) <400> SEQUENCE: 5
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcc
60 agaggagtcc aggtgcagct gaaggagtca ggacctggcc tggtggcgcc
ctcacagagc 120 ctgtccatca catgcaccgt ctcagggttc tcattaaccg
gctatggtgt aaactgggtt 180 cgccagcctc caggaaaggg tctggagtgg
ctgggaatga tatggggtga tggaagcaca 240 gactataatt cagctctcaa
atccagacta tcgatcacca aggacaactc caagagccaa 300 gttttcttaa
aaatgaacag tctgcaaact gatgacacag ccagatacta ctgtgcccga 360
gatggttata gtaactttca ttactatgtt atggactact ggggtcaagg aacctcagtc
420 accgtctcct ctgggggtgg aggctctggt ggcggtggat ccggcggagg
tgggtcgggt 480 ggcggcggat ctgacattgt gctcacccaa tctccagctt
ctttggctgt gtctctaggt 540 cagagagcca ccatctcctg cagagccagt
gaaagtgttg aatattatgt cacaagttta 600 atgcagtggt accaacagaa
accaggacag ccacccaaac tcctcatctc tgctgctagc 660 aacgtagaat
ctggggtccc tgccaggttt agtggcagtg ggtctgggac agactttagc 720
ctcaacatcc atcctgtgga ggaggatgat attgcaatgt atttctgtca gcaaagtagg
780 aaggttccat ggacgttcgg tggaggcacc aagctggaaa tcaaacgt 828
<210> SEQ ID NO 6 <211> LENGTH: 276 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide - anti-CD28
(2e12) HL (AA) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(23) <223> OTHER
INFORMATION: Leader <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (24)..(144) <223> OTHER
INFORMATION: VH <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (145)..(164) <223> OTHER
INFORMATION: Linker <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (165)..(276) <223> OTHER
INFORMATION: VL <400> SEQUENCE: 6 Met Asp Phe Gln Val Gln Ile
Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg
Gly Val Gln Val Gln Leu Lys Glu Ser Gly Pro 20 25 30 Gly Leu Val
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 35 40 45 Gly
Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 50 55
60 Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr
65 70 75 80 Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys
Asp Asn 85 90 95 Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu
Gln Thr Asp Asp 100 105 110 Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly
Tyr Ser Asn Phe His Tyr 115 120 125 Tyr Val Met Asp Tyr Trp Gly Gln
Gly Thr Ser Val Thr Val Ser Ser 130 135 140 Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 145 150 155 160 Gly Gly Gly
Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 165 170 175 Val
Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 180 185
190 Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro
195 200 205 Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val
Glu Ser 210 215 220 Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Ser 225 230 235 240 Leu Asn Ile His Pro Val Glu Glu Asp
Asp Ile Ala Met Tyr Phe Cys 245 250 255 Gln Gln Ser Arg Lys Val Pro
Trp Thr Phe Gly Gly Gly Thr Lys Leu 260 265 270 Glu Ile Lys Arg 275
<210> SEQ ID NO 7 <211> LENGTH: 30 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - Heavy Chain GSP1
<400> SEQUENCE: 7 aggtgctgga ggggacagtc actgagctgc 30
<210> SEQ ID NO 8 <211> LENGTH: 28 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - Nested Heavy
Chain <400> SEQUENCE: 8 gtcacwgtca ctgrctcagg gaartagc 28
<210> SEQ ID NO 9 <211> LENGTH: 33 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - Light Chain GSP1
<400> SEQUENCE: 9 gggtgctgct catgctgtag gtgctgtctt tgc 33
<210> SEQ ID NO 10 <211> LENGTH: 32 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - Nested Light
Chain <400> SEQUENCE: 10 caagaagcac acgactgagg cacctccaga tg
32 <210> SEQ ID NO 11 <211> LENGTH: 36 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer - Race
Abridged Anchor Primer <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (24)..(25) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (29)..(30) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (34)..(35)
<223> OTHER INFORMATION: n is a, c, g, or t <400>
SEQUENCE: 11 ggccacgcgt cgactagtac gggnngggnn gggnng 36 <210>
SEQ ID NO 12 <211> LENGTH: 20 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - T7 primer
<400> SEQUENCE: 12 gtaatacgac tcactatagg 20 <210> SEQ
ID NO 13 <211> LENGTH: 18 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - M13 reverse primer
<400> SEQUENCE: 13 caggaaacag ctatgacc 18 <210> SEQ ID
NO 14 <211> LENGTH: 15 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 14 Glu Pro Lys Ser Cys
Asp Lys Thr His Thr Cys Pro Pro Cys Pro 1 5 10 15 <210> SEQ
ID NO 15 <211> LENGTH: 46 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 15 gcgataaagc
ttgccgccat ggaagcacca gcgcagcttc tcttcc 46 <210> SEQ ID NO 16
<211> LENGTH: 50 <212> TYPE: DNA <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 16 accagcgcag cttctcttcc
tcctgctact ctggctccca gataccaccg 50 <210> SEQ ID NO 17
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 17 ggctcccaga taccaccggt
caaattgttc tctcccagtc tccag 45 <210> SEQ ID NO 18 <211>
LENGTH: 35 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 2H7VHNheF <400> SEQUENCE: 18 gcgatagcta
gccaggctta tctacagcag tctgg 35 <210> SEQ ID NO 19 <211>
LENGTH: 43 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - G4SNheR <400> SEQUENCE: 19 gcgatagcta
gccccacctc ctccagatcc accaccgccc gag 43 <210> SEQ ID NO 20
<211> LENGTH: 35 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - 015VHXhoR <400> SEQUENCE: 20
gcgtactcga ggagacggtg accgtggtcc ctgtg 35 <210> SEQ ID NO 21
<211> LENGTH: 37 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - G1HC-Xho <400> SEQUENCE: 21
gcagtctcga gcgagcccaa atcttgtgac aaaactc 37 <210> SEQ ID NO
22 <211> LENGTH: 37 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - G1H-S-Xho <400>
SEQUENCE: 22 gcagtctcga gcgagcccaa atcttctgac aaaactc 37
<210> SEQ ID NO 23 <211> LENGTH: 36 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - CH3REcoR1
<400> SEQUENCE: 23 gcgtgagaat tcttacccgg agacagggag aggctc 36
<210> SEQ ID NO 24 <211> LENGTH: 32 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - G1 XBZ-R
<400> SEQUENCE: 24 gcgacgtcta gagtcattta cccggagaca gg 32
<210> SEQ ID NO 25 <211> LENGTH: 54 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - G4SLinkR1-S
<400> SEQUENCE: 25 aattatggtg gcggtggctc gggcggtggt
ggatctggag gaggtgggag tggg 54 <210> SEQ ID NO 26 <211>
LENGTH: 54 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - G4SLinkR1-AS <400> SEQUENCE: 26 aattcccact
cccacctcct ccagatccac caccgcccga gccaccgcca ccat 54 <210> SEQ
ID NO 27 <211> LENGTH: 36 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 2E12VLXbaR <400>
SEQUENCE: 27 gcgtgtctag attaacgttt gatttccagc ttggtg 36 <210>
SEQ ID NO 28 <211> LENGTH: 35 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 2E12VLR1F
<400> SEQUENCE: 28 gcgatgaatt ctgacattgt gctcacccaa tctcc 35
<210> SEQ ID NO 29 <211> LENGTH: 34 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 2E12VHR1F
<400> SEQUENCE: 29 gcgatgaatt ctcaggtgca gctgaaggag tcag 34
<210> SEQ ID NO 30 <211> LENGTH: 37 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 2E12VHXbaR
<400> SEQUENCE: 30 gcgagtctag attaagagga gacggtgact gaggttc
37 <210> SEQ ID NO 31 <211> LENGTH: 27 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
2e12VHdXbaF1 <400> SEQUENCE: 31 gggtctggag tggctgggaa tgatatg
27 <210> SEQ ID NO 32 <211> LENGTH: 28 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
2e12VHdXbaR1 <400> SEQUENCE: 32 attcccagcc actccagacc
ctttcctg 28 <210> SEQ ID NO 33 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - IgBsrG1F <400> SEQUENCE: 33 gagaaccaca ggtgtacacc
ctg 23 <210> SEQ ID NO 34 <211> LENGTH: 25 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer - IgBsrG1R
<400> SEQUENCE: 34 gcagggtgta cacctgtggt tctcg 25 <210>
SEQ ID NO 35 <211> LENGTH: 17 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - M13R <400>
SEQUENCE: 35 caggaaacag ctatgac 17 <210> SEQ ID NO 36
<211> LENGTH: 18 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - M13F <400> SEQUENCE: 36
gtaaaacgac ggccagtg 18 <210> SEQ ID NO 37 <211> LENGTH:
20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - T7 <400> SEQUENCE: 37 gtaatacgac tcactatagg 20
<210> SEQ ID NO 38 <211> LENGTH: 17 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - pD18F-17
<400> SEQUENCE: 38 aactagagaa cccactg 17 <210> SEQ ID
NO 39 <211> LENGTH: 20 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - pD18F-20 <400>
SEQUENCE: 39 gctaactaga gaacccactg 20 <210> SEQ ID NO 40
<211> LENGTH: 18 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - pD18F-1 <400> SEQUENCE: 40
atacgactca ctataggg 18 <210> SEQ ID NO 41 <211> LENGTH:
19 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - pD18R-s <400> SEQUENCE: 41 gctctagcat ttaggtgac 19
<210> SEQ ID NO 42 <211> LENGTH: 18 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - CH3seqF1
<400> SEQUENCE: 42 catgaggctc tgcacaac 18 <210> SEQ ID
NO 43 <211> LENGTH: 18 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - CH3seqF2 <400>
SEQUENCE: 43 cctctacagc aagctcac 18 <210> SEQ ID NO 44
<211> LENGTH: 19 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - CH3seqR1 <400> SEQUENCE: 44
ggttcttggt cagctcatc 19 <210> SEQ ID NO 45 <211>
LENGTH: 18 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - CH3seqR2 <400> SEQUENCE: 45 gtgagcttgc
tgtagagg 18 <210> SEQ ID NO 46 <211> LENGTH: 51
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - L1-11R <400> SEQUENCE: 46 gcgatagaat tcccagatcc
accaccgccc gagccaccgc caccataatt c 51 <210> SEQ ID NO 47
<211> LENGTH: 36 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - L1-6R <400> SEQUENCE: 47
gcgatagaat tcccagagcc accgccacca taattc 36 <210> SEQ ID NO 48
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - L3R <400> SEQUENCE: 48
gcgtatgaat tccccgagcc accgccaccc ttacccggag acagg 45 <210>
SEQ ID NO 49 <211> LENGTH: 49 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - L4R <400>
SEQUENCE: 49 gcgtatgaat tcccagatcc accaccgccc gagccaccgc cacccttac
49 <210> SEQ ID NO 50 <211> LENGTH: 44 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer - L5R
<400> SEQUENCE: 50 gcgtatgaat tcccgctgcc tcctccccca
gatccaccac cgcc 44 <210> SEQ ID NO 51 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - IgBsrG1F <400> SEQUENCE: 51 gagaaccaca ggtgtacacc
ctg 23 <210> SEQ ID NO 52 <211> LENGTH: 50 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer - L-CPPCPR
<400> SEQUENCE: 52 gcgatagaat tcggacaagg tggacacccc
ttacccggag acagggagag 50 <210> SEQ ID NO 53 <211>
LENGTH: 41 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - G281LH-NheR <400> SEQUENCE: 53 actgctgcag
ctggaccgcg ctagctccgc cgccacccga c 41 <210> SEQ ID NO 54
<211> LENGTH: 40 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - G281LH-NheF <400> SEQUENCE:
54 ggcggagcta gcgcggtcca gctgcagcag tctggacctg 40 <210> SEQ
ID NO 55 <211> LENGTH: 37 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - G281-LH-LPinF <400>
SEQUENCE: 55 gcgatcaccg gtgacatcca gatgactcag tctccag 37
<210> SEQ ID NO 56 <211> LENGTH: 37 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - G281-LH-HXhoR
<400> SEQUENCE: 56 gcgatactcg aggagacggt gactgaggtt ccttgac
37 <210> SEQ ID NO 57 <211> LENGTH: 38 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
G281-LH-LEcoF <400> SEQUENCE: 57 gcgatcgaat tcagacatcc
agatgactca gtctccag 38 <210> SEQ ID NO 58 <211> LENGTH:
43 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - G281-LH-HXbaR <400> SEQUENCE: 58 gcgattctag
attaggaaga gacggtgact gaggttcctt gac 43 <210> SEQ ID NO 59
<211> LENGTH: 37 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - G281-HL-HF <400> SEQUENCE: 59
gcgataaccg gtgcggtcca gctgcagcag tctggac 37 <210> SEQ ID NO
60 <211> LENGTH: 52 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - G281-HL-HR3 <400>
SEQUENCE: 60 gacccaccac cgcccgagcc accgccacca gaagagacgg tgactgaggt
tc 52 <210> SEQ ID NO 61 <211> LENGTH: 49 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
G281-HL-HR2 <400> SEQUENCE: 61 actcccgcct cctcctgatc
cgccgccacc cgacccacca ccgcccgag 49 <210> SEQ ID NO 62
<211> LENGTH: 42 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - G281-HL-HNheR <400> SEQUENCE:
62 gagtcatctg gatgtcgcta gcactcccgc ctcctcctga tc 42 <210>
SEQ ID NO 63 <211> LENGTH: 45 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - G281-HL-LNheF
<400> SEQUENCE: 63 atcaggagga ggcgggagtg ctagcgacat
ccagatgact cagtc 45 <210> SEQ ID NO 64 <211> LENGTH: 37
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - G281-HL-LXhoR <400> SEQUENCE: 64 gcgatactcg
agcctttgat ctccagttcg gtgcctc 37 <210> SEQ ID NO 65
<211> LENGTH: 42 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - G281-HL-LXhoR <400> SEQUENCE:
65 gcgatatcta gactcaacct ttgatctcca gttcggtgcc tc 42 <210>
SEQ ID NO 66 <211> LENGTH: 37 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - G281-HL-EcoF
<400> SEQUENCE: 66 gcgatagaat tcgcggtcca gctgcagcag tctggac
37 <210> SEQ ID NO 67 <211> LENGTH: 40 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
194-LH-LF1 <400> SEQUENCE: 67 gcgtatgaac cggtgacatc
cagatgacac agactacatc 40 <210> SEQ ID NO 68 <211>
LENGTH: 50 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-LF2 <400> SEQUENCE: 68 atccagatga
cacagactac atcctccctg tctgcctctc tgggagacag 50 <210> SEQ ID
NO 69 <211> LENGTH: 52 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-LF3 <400> SEQUENCE:
69 gtctgcctct ctgggagaca gagtcaccat cagttgcagg gcaagtcagg ac 52
<210> SEQ ID NO 70 <211> LENGTH: 50 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-LF4
<400> SEQUENCE: 70 gttgcagggc aagtcaggac attcgcaatt
atttaaactg gtatcagcag 50 <210> SEQ ID NO 71 <211>
LENGTH: 50 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-LF5 <400> SEQUENCE: 71 atttaaactg
gtatcagcag aaaccagatg gaactgttaa actcctgatc 50 <210> SEQ ID
NO 72 <211> LENGTH: 50 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-LF6 <400> SEQUENCE:
72 gaactgttaa actcctgatc tactacacat caagattaca ctcaggagtc 50
<210> SEQ ID NO 73 <211> LENGTH: 52 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-LF7
<400> SEQUENCE: 73 caagattaca ctcaggagtc ccatcaaggt
tcagtggcag tgggtctgga ac 52 <210> SEQ ID NO 74 <211>
LENGTH: 52 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-LR7 <400> SEQUENCE: 74 caggttggca
atggtgagag aataatctgt tccagaccca ctgccactga ac 52 <210> SEQ
ID NO 75 <211> LENGTH: 50 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-LR6 <400> SEQUENCE:
75 gcaaaagtaa gtggcaatat cttctggttg caggttggca atggtgagag 50
<210> SEQ ID NO 76 <211> LENGTH: 51 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-LR5
<400> SEQUENCE: 76 gaacgtccac ggaagcgtat taccctgttg
gcaaaagtaa gtggcaatat c 51 <210> SEQ ID NO 77 <211>
LENGTH: 52 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-LR4 <400> SEQUENCE: 77 cgtttggtta
ccagtttggt gcctccaccg aacgtccacg gaagcgtatt ac 52 <210> SEQ
ID NO 78 <211> LENGTH: 46 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-LR3 <400> SEQUENCE:
78 accaccgccc gagccaccgc caccccgttt ggttaccagt ttggtg 46
<210> SEQ ID NO 79 <211> LENGTH: 50 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-LR2
<400> SEQUENCE: 79 gctagcgctc ccacctcctc cagatccacc
accgcccgag ccaccgccac 50 <210> SEQ ID NO 80 <211>
LENGTH: 42 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-LH-LR1 <400> SEQUENCE: 80 gttgcagctg
gacctcgcta gcgctcccac ctcctccaga tc 42 <210> SEQ ID NO 81
<211> LENGTH: 54 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - 194-LH-HF1 <400> SEQUENCE: 81
gatctggagg aggtgggagc gctagcgagg tccagctgca acagtctgga cctg 54
<210> SEQ ID NO 82 <211> LENGTH: 50 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-HF2
<400> SEQUENCE: 82 agctgcaaca gtctggacct gaactggtga
agcctggagc ttcaatgaag 50 <210> SEQ ID NO 83 <211>
LENGTH: 50 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-HF3 <400> SEQUENCE: 83 agcctggagc
ttcaatgaag atttcctgca aggcctctgg ttactcattc 50 <210> SEQ ID
NO 84 <211> LENGTH: 53 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-HF4 <400> SEQUENCE:
84 gcaaggcctc tggttactca ttcactggct acatcgtgaa ctggctgaag cag 53
<210> SEQ ID NO 85 <211> LENGTH: 52 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-HF5
<400> SEQUENCE: 85 atcgtgaact ggctgaagca gagccatgga
aagaaccttg agtggattgg ac 52 <210> SEQ ID NO 86 <211>
LENGTH: 52 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-HF6 <400> SEQUENCE: 86 gaaccttgag
tggattggac ttattaatcc atacaaaggt cttactacct ac 52 <210> SEQ
ID NO 87 <211> LENGTH: 52 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-HR6 <400> SEQUENCE:
87 aatgtggcct tgcccttgaa tttctggttg taggtagtaa gacctttgta tg 52
<210> SEQ ID NO 88 <211> LENGTH: 52 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-HR5
<400> SEQUENCE: 88 catgtaggct gtgctggatg acttgtctac
agttaatgtg gccttgccct tg 52 <210> SEQ ID NO 89 <211>
LENGTH: 55 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-HR4 <400> SEQUENCE: 89 actgcagagt
cttcagatgt cagactgagg agctccatgt aggctgtgct ggatg 55 <210>
SEQ ID NO 90 <211> LENGTH: 52 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-HR3
<400> SEQUENCE: 90 accatagtac ccagatcttg cacagtaata
gactgcagag tcttcagatg tc 52 <210> SEQ ID NO 91 <211>
LENGTH: 52 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-HR2 <400> SEQUENCE: 91 gcgccccaga
catcgaagta ccagtccgag tcaccatagt acccagatct tg 52 <210> SEQ
ID NO 92 <211> LENGTH: 52 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-LH-HR1 <400>
SEQUENCE: 92 gcgaatactc gaggagacgg tgaccgtggt ccctgcgccc cagacatcga
ag 52 <210> SEQ ID NO 93 <211> LENGTH: 42 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
194-HL-HF1 <400> SEQUENCE: 93 gcgtatgaac cggtgaggtc
cagctgcaac agtctggacc tg 42 <210> SEQ ID NO 94 <211>
LENGTH: 55 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-HL-HR1 <400> SEQUENCE: 94 accgccacca
gaggagacgg tgaccgtggt ccctgcgccc cagacatcga agtac 55 <210>
SEQ ID NO 95 <211> LENGTH: 52 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-HL-HR0
<400> SEQUENCE: 95 acctcctcca gatccaccac cgcccgagcc
accgccacca gaggagacgg tg 52 <210> SEQ ID NO 96 <211>
LENGTH: 49 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-HL-LF1 <400> SEQUENCE: 96 gcgggggagg
tggcagtgct agcgacatcc agatgacaca gactacatc 49 <210> SEQ ID NO
97 <211> LENGTH: 34 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-HL-LR3Xho <400>
SEQUENCE: 97 gcgaatactc gagcgtttgg ttaccagttt ggtg 34 <210>
SEQ ID NO 98 <211> LENGTH: 37 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-HL-LR3Xba
<400> SEQUENCE: 98 gcgatatcta gattaccgtt tggttaccag tttggtg
37 <210> SEQ ID NO 99 <211> LENGTH: 43 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
194-HL-HF1R1 <400> SEQUENCE: 99 gcgtatgaga attcagaggt
ccagctgcaa cagtctggac ctg 43 <210> SEQ ID NO 100 <211>
LENGTH: 41 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-LH-LF1R1 <400> SEQUENCE: 100
gcgtatgaga attctgacat ccagatgaca cagactacat c 41 <210> SEQ ID
NO 101 <211> LENGTH: 54 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-LH-HR1Xba <400>
SEQUENCE: 101 gcgtatctag attaggagac ggtgaccgtg gtccctgcgc
cccagacatc gaag 54 <210> SEQ ID NO 102 <211> LENGTH:
725 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polynucleotide - G28-1 VLVH (DNA) <400> SEQUENCE: 102
accggtgaca tccagatgac tcagtctcca gcctccctat ctgcatctgt gggagagact
60 gtcaccatca catgtcgaac aagtgaaaat gtttacagtt atttggcttg
gtatcagcag 120 aaacagggaa aatctcctca gctcctggtc tcttttgcaa
aaaccttagc agaaggtgtg 180 ccatcaaggt tcagtggcag tggatcaggc
acacagtttt ctctgaagat cagcagcctg 240 cagcctgaag attctggaag
ttatttctgt caacatcatt ccgataatcc gtggacgttc 300 ggtggaggca
ccgaactgga gatcaaaggt ggcggtggct cgggcggtgg tgggtcgggt 360
ggcggcggat ctgctagcgc agtccagctg cagcagtctg gacctgagct ggaaaagcct
420 ggcgcttcag tgaagatttc ctgcaaggct tctggttact cattcactgg
ctacaatatg 480 aactgggtga agcagaataa tggaaagagc cttgagtgga
ttggaaatat tgatccttat 540 tatggtggta ctacctacaa ccggaagttc
aagggcaagg ccacattgac tgtagacaaa 600 tcctccagca cagcctacat
gcagctcaag agtctgacat ctgaggactc tgcagtctat 660 tactgtgcaa
gatcggtcgg ccctatggac tactggggtc aaggaacctc agtcaccgtc 720 tcgag
725 <210> SEQ ID NO 103 <211> LENGTH: 239 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide -
G-28-1 VLVH (AA) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(107) <223> OTHER
INFORMATION: VL <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (108)..(124) <223> OTHER
INFORMATION: Linker <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (125)..(239) <223> OTHER
INFORMATION: VH <400> SEQUENCE: 103 Asp Ile Gln Met Thr Gln
Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Glu Thr Val Thr
Ile Thr Cys Arg Thr Ser Glu Asn Val Tyr Ser Tyr 20 25 30 Leu Ala
Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 35 40 45
Ser Phe Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Ser Ser Leu Gln
Pro 65 70 75 80 Glu Asp Ser Gly Ser Tyr Phe Cys Gln His His Ser Asp
Asn Pro Trp 85 90 95 Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys
Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ala Ser Ala Val Gln Leu 115 120 125 Gln Gln Ser Gly Pro Glu Leu
Glu Lys Pro Gly Ala Ser Val Lys Ile 130 135 140 Ser Cys Lys Ala Ser
Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn Trp 145 150 155 160 Val Lys
Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile Gly Asn Ile Asp 165 170 175
Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys Gly Lys Ala 180
185 190 Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu
Lys 195 200 205 Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala
Arg Ser Val 210 215 220 Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser
Val Thr Val Ser 225 230 235 <210> SEQ ID NO 104 <211>
LENGTH: 767 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polynucleotide - G28-1 VHVL (DNA) <400> SEQUENCE:
104 accggtgagg tccagctgca acagtctgga cctgaactgg tgaagcctgg
agcttcaatg 60 aagatttcct gcaaggcctc tggttactca ttcactggct
acatcgtgaa ctggctgaag 120 cagagccatg gaaagaacct tgagtggatt
ggacttatta atccatacaa aggtcttact 180 acctacaacc agaaattcaa
gggcaaggcc acattaactg tagacaagtc atccagcaca 240 gcctacatgg
agctcctcag tctgacatct gaagactctg cagtctatta ctgtgcaaga 300
tctgggtact atggtgactc ggactggtac ttcgatgtct ggggcgcagg gaccacggtc
360 accgtctcct ctggtggcgg tggctcgggc ggtggtggat ctggaggagg
tgggagcggg 420 ggaggtggca gtgctagcga catccagatg acacagacta
catcctccct gtctgcctct 480 ctgggagaca gagtcaccat cagttgcagg
gcaagtcagg acattcgcaa ttatttaaac 540 tggtatcagc agaaaccaga
tggaactgtt aaactcctga tctactacac atcaagatta 600 cactcaggag
tcccatcaag gttcagtggc agtgggtctg gaacagatta ttctctcacc 660
attgccaacc tgcaaccaga agatattgcc acttactttt gccaacaggg taatacgctt
720 ccgtggacgt tcggtggagg caccaaactg gtaaccaaac gctcgag 767
<210> SEQ ID NO 105 <211> LENGTH: 253 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide - G28-1 VHVL
(AA) <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(121) <223> OTHER INFORMATION: VH
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (122)..(144) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (145)..(253) <223> OTHER INFORMATION: VL
<400> SEQUENCE: 105 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu
Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Met Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ser Phe Thr Gly Tyr 20 25 30 Ile Val Asn Trp Leu Lys
Gln Ser His Gly Lys Asn Leu Glu Trp Ile 35 40 45 Gly Leu Ile Asn
Pro Tyr Lys Gly Leu Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val
Trp 100 105 110 Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ala Ser 130 135 140 Asp Ile Gln Met Thr Gln Thr Thr Ser
Ser Leu Ser Ala Ser Leu Gly 145 150 155 160 Asp Arg Val Thr Ile Ser
Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 165 170 175 Leu Asn Trp Tyr
Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 180 185 190 Tyr Tyr
Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 195 200 205
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro 210
215 220 Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro
Trp 225 230 235 240 Thr Phe Gly Gly Gly Thr Lys Leu Val Thr Lys Arg
Ser 245 250 <210> SEQ ID NO 106 <211> LENGTH: 749
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polynucleotide - G19-4 VLVH (DNA) <400> SEQUENCE: 106
accggtgaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga
60 gtcaccatca gttgcagggc aagtcaggac attcgcaatt atttaaactg
gtatcagcag 120 aaaccagatg gaactgttaa actcctgatc tactacacat
caagattaca ctcaggagtc 180 ccatcaaggt tcagtggcag tgggtctgga
acagattatt ctctcaccat tgccaacctg 240 caaccagaag atattgccac
ttacttttgc caacagggta atacgcttcc gtggacgttc 300 ggtggaggca
ccaaactggt aaccaaacgg ggtggcggtg gctcgggcgg tggtggatct 360
ggaggaggtg ggagcgctag cgaggtccag ctgcaacagt ctggacctga actggtgaag
420 cctggagctt caatgaagat ttcctgcaag gcctctggtt actcattcac
tggctacatc 480 gtgaactggc tgaagcagag ccatggaaag aaccttgagt
ggattggact tattaatcca 540 tacaaaggtc ttactaccta caaccagaaa
ttcaagggca aggccacatt aactgtagac 600 aagtcatcca gcacagccta
catggagctc ctcagtctga catctgaaga ctctgcagtc 660 tattactgtg
caagatctgg gtactatggt gactcggact ggtacttcga tgtctggggc 720
gcagggacca cggtcaccgt ctcctcgag 749 <210> SEQ ID NO 107
<211> LENGTH: 247 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide - G-19-4 VLVH (AA) <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1)..(108) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(109)..(125) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(126)..(247) <223> OTHER INFORMATION: VH <400>
SEQUENCE: 107 Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala
Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
Asp Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Asp
Gly Thr Val Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His
Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr
Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro 65 70 75 80 Glu Asp Ile
Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr
Phe Gly Gly Gly Thr Lys Leu Val Thr Lys Arg Gly Gly Gly Gly 100 105
110 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Val Gln
115 120 125 Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser
Met Lys 130 135 140 Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly
Tyr Ile Val Asn 145 150 155 160 Trp Leu Lys Gln Ser His Gly Lys Asn
Leu Glu Trp Ile Gly Leu Ile 165 170 175 Asn Pro Tyr Lys Gly Leu Thr
Thr Tyr Asn Gln Lys Phe Lys Gly Lys 180 185 190 Ala Thr Leu Thr Val
Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu 195 200 205 Leu Ser Leu
Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser 210 215 220 Gly
Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly 225 230
235 240 Thr Thr Val Thr Val Ser Ser 245 <210> SEQ ID NO 108
<211> LENGTH: 752 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polynucleotide - G19-4 VHVL (DNA)
<400> SEQUENCE: 108 accggtgagg tccagctgca acagtctgga
cctgaactgg tgaagcctgg agcttcaatg 60 aagatttcct gcaaggcctc
tggttactca ttcactggct acatcgtgaa ctggctgaag 120 cagagccatg
gaaagaacct tgagtggatt ggacttatta atccatacaa aggtcttact 180
acctacaacc agaaattcaa gggcaaggcc acattaactg tagacaagtc atccagcaca
240 gcctacatgg agctcctcag tctgacatct gaagactctg cagtctatta
ctgtgcaaga 300 tctgggtact atggtgactc ggactggtac ttcgatgtct
ggggcgcagg gaccacggtc 360 accgtctcct ctggtggcgg tggctcgggc
ggtggtggat ctggaggagg tgggagcgct 420 agcgacatcc agatgacaca
gactacatcc tccctgtctg cctctctggg agacagagtc 480 accatcagtt
gcagggcaag tcaggacatt cgcaattatt taaactggta tcagcagaaa 540
ccagatggaa ctgttaaact cctgatctac tacacatcaa gattacactc aggagtccca
600 tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattgc
caacctgcaa 660 ccagaagata ttgccactta cttttgccaa cagggtaata
cgcttccgtg gacgttcggt 720 ggaggcacca aactggtaac caaacgctcg ag 752
<210> SEQ ID NO 109 <211> LENGTH: 248 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide - G19-4 VHVL
(AA) <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(122) <223> OTHER INFORMATION: VH
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (123)..(139) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (140)..(248) <223> OTHER INFORMATION: VL
<400> SEQUENCE: 109 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu
Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Met Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ser Phe Thr Gly Tyr 20 25 30 Ile Val Asn Trp Leu Lys
Gln Ser His Gly Lys Asn Leu Glu Trp Ile 35 40 45 Gly Leu Ile Asn
Pro Tyr Lys Gly Leu Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val
Trp 100 105 110 Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser
Asp Ile Gln Met Thr 130 135 140 Gln Thr Thr Ser Ser Leu Ser Ala Ser
Leu Gly Asp Arg Val Thr Ile 145 150 155 160 Ser Cys Arg Ala Ser Gln
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln 165 170 175 Gln Lys Pro Asp
Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 180 185 190 Leu His
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205
Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro Glu Asp Ile Ala Thr 210
215 220 Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gly
Gly 225 230 235 240 Thr Lys Leu Val Thr Lys Arg Ser 245 <210>
SEQ ID NO 110 <211> LENGTH: 45 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - ssc(s)-hIgG1
(DNA) <400> SEQUENCE: 110 gagcccaaat cttctgacaa aactcacaca
tctccaccgt gctca 45 <210> SEQ ID NO 111 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide - ssc(s)-hIgG1 (AA) <400> SEQUENCE: 111 Glu Pro Lys
Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 1 5 10 15
<210> SEQ ID NO 112 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - scc(s)-hIgG1
(DNA) <400> SEQUENCE: 112 gagcccaaat cttctgacaa aactcacaca
tgtccaccgt gctca 45 <210> SEQ ID NO 113 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide - scc(s)-hIgG1 (AA) <400> SEQUENCE: 113 Glu Pro Lys
Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 1 5 10 15
<210> SEQ ID NO 114 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - css(s)-hIgG1
(DNA) <400> SEQUENCE: 114 gagcccaaat cttgtgacaa aactcacaca
tctccaccga gctca 45 <210> SEQ ID NO 115 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide - css(s)-hIgG1 (AA) <400> SEQUENCE: 115 Glu Pro Lys
Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 1 5 10 15
<210> SEQ ID NO 116 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polynucleotide -
scs(s)-hIgG1 (DNA) <400> SEQUENCE: 116 gagcccaaat cttgtgacaa
aactcacaca tgtccaccga gctca 45 <210> SEQ ID NO 117
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide - scs(s)-hIgG1 (AA) <400>
SEQUENCE: 117 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
Ser Ser 1 5 10 15 <210> SEQ ID NO 118 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 118 gagcccaaat cttgtgacaa aactcacaca
tgtccaccgt gctca 45 <210> SEQ ID NO 119 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
region <400> SEQUENCE: 119 Glu Pro Lys Ser Cys Asp Lys Thr
His Thr Cys Pro Pro Cys Ser 1 5 10 15 <210> SEQ ID NO 120
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer <400> SEQUENCE: 120 gagcccaaat
cttgtgacaa aactcacaca tgtccaccgt gccca 45 <210> SEQ ID NO 121
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region <400> SEQUENCE: 121 Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 1 5 10 15
<210> SEQ ID NO 122 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 122 gagcccaaat cttctgacaa aactcacaca tctccaccga gccca 45
<210> SEQ ID NO 123 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion linker region <400>
SEQUENCE: 123 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro
Ser Pro 1 5 10 15 <210> SEQ ID NO 124 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - csc(p)-hIgG1 (DNA) <400> SEQUENCE: 124 gagcccaaat
cttgtgacaa aactcacaca tctccaccgt gccca 45 <210> SEQ ID NO 125
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region - csc(p)-hIgG1 (AA) <400>
SEQUENCE: 125 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro
Cys Pro 1 5 10 15 <210> SEQ ID NO 126 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - ssc(p)-hIgG1 (DNA) <400> SEQUENCE: 126 gagcccaaat
cttctgacaa aactcacaca tctccaccgt gccca 45 <210> SEQ ID NO 127
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region - ssc(p)-hIgG1 (AA) <400>
SEQUENCE: 127 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro
Cys Pro 1 5 10 15 <210> SEQ ID NO 128 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - scc(p)-hIgG1 (DNA) <400> SEQUENCE: 128 gagcccaaat
cttctgacaa aactcacaca tgtccaccgt gccca 45 <210> SEQ ID NO 129
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region - scc(p)-hIgG1 (AA) <400>
SEQUENCE: 129 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
Cys Pro 1 5 10 15 <210> SEQ ID NO 130 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - css(p)-hIgG1 (DNA) <400> SEQUENCE: 130 gagcccaaat
cttgtgacaa aactcacaca tctccaccga gccca 45 <210> SEQ ID NO 131
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region - css(p)-hIgG1 (AA) <400>
SEQUENCE: 131 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro
Ser Pro 1 5 10 15 <210> SEQ ID NO 132 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - ssc(p)-hIgG1 (DNA) <400> SEQUENCE: 132 gagcccaaat
cttgtgacaa aactcacaca tgtccaccga gccca 45 <210> SEQ ID NO 133
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region - ssc(p)-hIgG1 (DNA)
<400> SEQUENCE: 133 Glu Pro Lys Ser Ser Asp Lys Thr His Thr
Cys Pro Pro Ser Pro 1 5 10 15 <210> SEQ ID NO 134 <211>
LENGTH: 18 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - ssc(p) (DNA) <400> SEQUENCE: 134
agttgtccac cgtgccca 18 <210> SEQ ID NO 135 <211>
LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion linker region <400> SEQUENCE: 135 Ser Cys Pro Pro
Cys Pro 1 5 <210> SEQ ID NO 136 <211> LENGTH: 7
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 136 tgatcag 7 <210> SEQ ID NO
137 <211> LENGTH: 2 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic peptide <400> SEQUENCE: 137 Asp
Gln 1 <210> SEQ ID NO 138 <211> LENGTH: 7 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer
<400> SEQUENCE: 138 ctcgagt 7 <210> SEQ ID NO 139
<211> LENGTH: 2 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide <400> SEQUENCE: 139 Ser Ser 1
<210> SEQ ID NO 140 <211> LENGTH: 654 <212> TYPE:
DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 140
gcacctgaac tcctgggtgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc
60 ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag
ccacgaagac 120 cctgaggtca agttcaactg gtacgtggac ggcgtggagg
tgcataatgc caagacaaag 180 ccgcgggagg agcagtacaa cagcacgtac
cgtgtggtca gcgtcctcac cgtcctgcac 240 caggactggc tgaatggcaa
ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc 300 cccatcgaga
aaacaatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 360
ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa
420 ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc
ggagaacaac 480 tacaagacca cgcctcccgt gctggactcc gacggctcct
tcttcctcta cagcaagctc 540 accgtggaca agagcaggtg gcagcagggg
aacgtcttct catgctccgt gatgcatgag 600 gctctgcaca accactacac
gcagaagagc ctctccctgt ctccgggtaa atga 654 <210> SEQ ID NO 141
<211> LENGTH: 217 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 141 Ala Pro Glu Leu Leu Gly Gly
Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45 Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55
60 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys 85 90 95 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Asp Glu Leu 115 120 125 Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 180 185
190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
195 200 205 Lys Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210>
SEQ ID NO 142 <211> LENGTH: 654 <212> TYPE: DNA
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 142
gcacctgaac tcctgggtgg atcgtcagtc ttcctcttcc ccccaaaacc caaggacacc
60 ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag
ccacgaagac 120 cctgaggtca agttcaactg gtacgtggac ggcgtggagg
tgcataatgc caagacaaag 180 ccgcgggagg agcagtacaa cagcacgtac
cgtgtggtca gcgtcctcac cgtcctgcac 240 caggactggc tgaatggcaa
ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc 300 cccatcgaga
aaacaatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 360
ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa
420 ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc
ggagaacaac 480 tacaagacca cgcctcccgt gctggactcc gacggctcct
tcttcctcta cagcaagctc 540 accgtggaca agagcaggtg gcagcagggg
aacgtcttct catgctccgt gatgcatgag 600 gctctgcaca accactacac
gcagaagagc ctctccctgt ctccgggtaa atga 654 <210> SEQ ID NO 143
<211> LENGTH: 217 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 143 Ala Pro Glu Leu Leu Gly Gly
Ser Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45 Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55
60 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys 85 90 95 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Asp Glu Leu 115 120 125 Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 180 185
190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
195 200 205 Lys Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210>
SEQ ID NO 144 <211> LENGTH: 654 <212> TYPE: DNA
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 144
gcacctgaac tcctgggtgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc
60 ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag
ccacgaagac 120 cctgaggtca agttcaactg gtacgtggac ggcgtggagg
tgcataatgc caagacaaag 180 ccgcgggagg agcagtacaa cagcacgtac
cgtgtggtca gcgtcctcac cgtcctgcac 240 caggactggc tgaatggcaa
ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc 300 tccatcgaga
aaacaatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 360
ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa
420 ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc
ggagaacaac 480 tacaagacca cgcctcccgt gctggactcc gacggctcct
tcttcctcta cagcaagctc 540 accgtggaca agagcaggtg gcagcagggg
aacgtcttct catgctccgt gatgcatgag 600 gctctgcaca accactacac
gcagaagagc ctctccctgt ctccgggtaa atga 654 <210> SEQ ID NO 145
<211> LENGTH: 217 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 145 Ala Pro Glu Leu Leu Gly Gly
Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45 Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55
60 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys 85 90 95 Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Asp Glu Leu 115 120 125 Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 180 185
190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
195 200 205 Lys Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210>
SEQ ID NO 146 <211> LENGTH: 654 <212> TYPE: DNA
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 146
gcacctgaac tcctgggtgg atcgtcagtc ttcctcttcc ccccaaaacc caaggacacc
60 ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag
ccacgaagac 120 cctgaggtca agttcaactg gtacgtggac ggcgtggagg
tgcataatgc caagacaaag 180 ccgcgggagg agcagtacaa cagcacgtac
cgtgtggtca gcgtcctcac cgtcctgcac 240 caggactggc tgaatggcaa
ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc 300 tccatcgaga
aaacaatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 360
ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa
420 ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc
ggagaacaac 480 tacaagacca cgcctcccgt gctggactcc gacggctcct
tcttcctcta cagcaagctc 540 accgtggaca agagcaggtg gcagcagggg
aacgtcttct catgctccgt gatgcatgag 600 gctctgcaca accactacac
gcagaagagc ctctccctgt ctccgggtaa atga 654 <210> SEQ ID NO 147
<211> LENGTH: 217 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 147 Ala Pro Glu Leu Leu Gly Gly
Ser Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45 Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55
60 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys 85 90 95 Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Asp Glu Leu 115 120 125 Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 180 185
190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
195 200 205 Lys Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210>
SEQ ID NO 148 <211> LENGTH: 60 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - STD1 (DNA)
<400> SEQUENCE: 148 aattatggtg gcggtggctc gggcggtggt
ggatctggag gaggtgggag tgggaattct 60 <210> SEQ ID NO 149
<211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region - STD1 (AA) <400>
SEQUENCE: 149 Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 1 5 10 15 Ser Gly Asn Ser 20 <210> SEQ ID NO 150
<211> LENGTH: 114 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - STD2 (DNA) <400> SEQUENCE:
150 aattatggtg gcggtggctc gggcggtggt ggatctggag gaggtgggag
tgggaattat 60 ggtggcggtg gctcgggcgg tggtggatct ggaggaggtg
ggagtgggaa ttct 114 <210> SEQ ID NO 151 <211> LENGTH:
38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
region - STD2 (AA) <400> SEQUENCE: 151 Asn Tyr Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 1 5 10 15 Ser Gly Asn
Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 20 25 30 Gly
Gly Ser Gly Asn Ser 35 <210> SEQ ID NO 152 <211>
LENGTH: 6 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - Linker H1 (PN) <400> SEQUENCE: 152 aattct
6 <210> SEQ ID NO 153 <211> LENGTH: 2 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion linker region - Linker H1
(AA) <400> SEQUENCE: 153 Asn Ser 1 <210> SEQ ID NO 154
<211> LENGTH: 24 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - Linker H2 (PN) <400>
SEQUENCE: 154 ggtggcggtg gctcggggaa ttct 24 <210> SEQ ID NO
155 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion linker region - Linker H2 (AA)
<400> SEQUENCE: 155 Gly Gly Gly Gly Ser Gly Asn Ser 1 5
<210> SEQ ID NO 156 <211> LENGTH: 30 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - Linker H3 (PN)
<400> SEQUENCE: 156 aattatggtg gcggtggctc tgggaattct 30
<210> SEQ ID NO 157 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion linker region - Linker H3
(AA) <400> SEQUENCE: 157 Asn Tyr Gly Gly Gly Gly Ser Gly Asn
Ser 1 5 10 <210> SEQ ID NO 158 <211> LENGTH: 39
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - Linker H4 (PN) <400> SEQUENCE: 158 ggtggcggtg
gctcgggcgg tggtggatct gggaattct 39 <210> SEQ ID NO 159
<211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region - Linker H4 (AA) <400>
SEQUENCE: 159 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 1
5 10 <210> SEQ ID NO 160 <211> LENGTH: 45 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer - Linker
H5 (PN) <400> SEQUENCE: 160 aattatggtg gcggtggctc gggcggtggt
ggatctggga attct 45 <210> SEQ ID NO 161 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
region - Linker H5 (AA) <400> SEQUENCE: 161 Asn Tyr Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 1 5 10 15 <210>
SEQ ID NO 162 <211> LENGTH: 54 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - Linker H6 (PN)
<400> SEQUENCE: 162 ggtggcggtg gctcgggcgg tggtggatct
gggggaggag gcagcgggaa ttct 54 <210> SEQ ID NO 163 <211>
LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion linker region - Linker H6 (AA) <400> SEQUENCE: 163
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5
10 15 Asn Ser <210> SEQ ID NO 164 <211> LENGTH: 24
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - Linker H7 (PN) <400> SEQUENCE: 164 gggtgtccac
cttgtccgaa ttct 24 <210> SEQ ID NO 165 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
region - Linker H7 (AA) <400> SEQUENCE: 165 Gly Cys Pro Pro
Cys Pro Asn Ser 1 5 <210> SEQ ID NO 166 <211> LENGTH:
45 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - Linker(G4S)3 <400> SEQUENCE: 166 ggtggcggtg
gatccggcgg aggtgggtcg ggtggcggcg gatct 45 <210> SEQ ID NO 167
<211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region - Linker(G3S)3 <400>
SEQUENCE: 167 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 1 5
10 <210> SEQ ID NO 168 <211> LENGTH: 60 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
Linker(G4S)4 <400> SEQUENCE: 168 ggtggcggtg gctcgggcgg
tggtggatct ggaggaggtg ggagcggggg aggtggcagt 60 <210> SEQ ID
NO 169 <211> LENGTH: 17 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion linker region - Linker(G3S)4
<400> SEQUENCE: 169 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
Gly Ser Gly Gly Gly Gly 1 5 10 15 Ser <210> SEQ ID NO 170
<211> LENGTH: 2337 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-STD1-2e12HL (DNA) <400>
SEQUENCE: 170 aagcttgccg ccatggattt tcaagtgcag attttcagct
tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc
tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat
gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga
agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct 240
tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc
300 agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag
ttttaaccca 360 cccacgttcg gtgctgggac caagctggag ctgaaagatg
gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct
tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa
gatgtcctgc aaggcttctg gctacacatt taccagttac 540 aatatgcact
gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat 600
ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta
660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga
agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat agtaactctt
actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat
caggagccca aatcttctga caaaactcac 840 acatccccac cgagctcagc
acctgaactc ctggggggac cgtcagtctt cctcttcccc 900 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 960
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa
acaatctcca aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc
tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1320
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc
1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa
cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc
agaagagcct ctccctgtct 1500 ccgggtaaga attatggtgg cggtggctcg
ggcggtggtg gatctggagg aggtgggagt 1560 gggaattctc aggtgcagct
gaaggagtca ggacctggcc tggtggcgcc ctcacagagc 1620 ctgtccatca
catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt 1680
cgccagcctc caggaaaggg tctggagtgg ctgggaatga tatggggtga tggaagcaca
1740 gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc
caagagccaa 1800 gttttcttaa aaatgaacag tctgcaaact gatgacacag
ccagatacta ctgtgctcga 1860 gatggttata gtaactttca ttactatgtt
atggactact ggggtcaagg aacctcagtc 1920 accgtctcct ctgggggtgg
aggctctggt ggcggtggat ccggcggagg tgggtcgggt 1980 ggcggcggat
ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt 2040
cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta
2100 atgcagtggt accaacagaa accaggacag ccacccaaac tcctcatctc
tgctgctagc 2160 aacgtagaat ctggggtccc tgccaggttt agtggcagtg
ggtctgggac agactttagc 2220 ctcaacatcc atcctgtgga ggaggatgat
attgcaatgt atttctgtca gcaaagtagg 2280 aaggttccat ggacgttcgg
tggaggcacc aagctggaaa tcaaacgtta atctaga 2337 <210> SEQ ID NO
171 <211> LENGTH: 772 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-STD1-2e12HL (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(22)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(128) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(281) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(519) <223> OTHER INFORMATION: EFD-BD2 linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (520)..(640) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (641)..(660) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (661)..(772) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 171 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Ser Gln Val
Gln Leu Lys Glu Ser Gly Pro 515 520 525 Gly Leu Val Ala Pro Ser Gln
Ser Leu Ser Ile Thr Cys Thr Val Ser 530 535 540 Gly Phe Ser Leu Thr
Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 545 550 555 560 Gly Lys
Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 565 570 575
Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 580
585 590 Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp
Asp 595 600 605 Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn
Phe His Tyr 610 615 620 Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser
Val Thr Val Ser Ser 625 630 635 640 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly 645 650 655 Gly Gly Gly Ser Asp Ile
Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 660 665 670 Val Ser Leu Gly
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 675 680 685 Val Glu
Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 690 695 700
Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 705
710 715 720 Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Ser 725 730 735 Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala
Met Tyr Phe Cys 740 745 750 Gln Gln Ser Arg Lys Val Pro Trp Thr Phe
Gly Gly Gly Thr Lys Leu 755 760 765 Glu Ile Lys Arg 770 <210>
SEQ ID NO 172 <211> LENGTH: 772 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sssIgG1(P238S/P331S)-STD1-2e12HL
(w/2e12 leader) (AA) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(22) <223> OTHER
INFORMATION: Leader <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (23)..(128) <223> OTHER
INFORMATION: VL <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (129)..(144) <223> OTHER
INFORMATION: Linker <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (145)..(265) <223> OTHER
INFORMATION: VH <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (268)..(282) <223> OTHER
INFORMATION: Hinge <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (500)..(519) <223> OTHER
INFORMATION: EFD-BD2 linker <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (520)..(640)
<223> OTHER INFORMATION: VH2 <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (641)..(660)
<223> OTHER INFORMATION: Linker2 <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(661)..(772) <223> OTHER INFORMATION: VL2 <400>
SEQUENCE: 172 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile
Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser
Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly Glu Lys Val
Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser Tyr Met His
Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys Pro Trp Ile
Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80 Ala Arg Phe
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85 90 95 Ser
Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 100 105
110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val
Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp Val Lys Gln
Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala Ile Tyr Pro
Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205 Lys Gly Lys
Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210 215 220 Met
Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 225 230
235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val
Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro
Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro Ser Ser Ala
Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330 335 His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 340 345 350
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 355
360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser
Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455 460 Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 465 470 475
480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Ser Gln Val Gln Leu Lys
Glu Ser Gly Pro 515 520 525 Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
Ile Thr Cys Thr Val Ser 530 535 540 Gly Phe Ser Leu Thr Gly Tyr Gly
Val Asn Trp Val Arg Gln Pro Pro 545 550 555 560 Gly Lys Gly Leu Glu
Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 565 570 575 Asp Tyr Asn
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 580 585 590 Ser
Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 595 600
605 Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr
610 615 620 Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val
Ser Ser 625 630 635 640 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 645 650 655 Gly Gly Gly Ser Asp Ile Val Leu Thr
Gln Ser Pro Ala Ser Leu Ala 660 665 670 Val Ser Leu Gly Gln Arg Ala
Thr Ile Ser Cys Arg Ala Ser Glu Ser 675 680 685 Val Glu Tyr Tyr Val
Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 690 695 700 Gly Gln Pro
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 705 710 715 720
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 725
730 735 Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe
Cys 740 745 750 Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly
Thr Lys Leu 755 760 765 Glu Ile Lys Arg 770 <210> SEQ ID NO
173 <211> LENGTH: 2322 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-STD1-2e12LH (DNA) <400>
SEQUENCE: 173 aagcttgccg ccatggattt tcaagtgcag attttcagct
tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc
tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat
gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga
agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct 240
tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc
300 agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag
ttttaaccca 360 cccacgttcg gtgctgggac caagctggag ctgaaagatg
gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct
tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa
gatgtcctgc aaggcttctg gctacacatt taccagttac 540 aatatgcact
gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat 600
ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta
660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga
agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat agtaactctt
actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat
caggagccca aatcttctga caaaactcac 840 acatccccac cgagcccagc
acctgaactc ctggggggac cgtcagtctt cctcttcccc 900 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 960
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa
acaatctcca aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc
tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1320
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc
1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa
cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc
agaagagcct ctccctgtct 1500 ccgggtaaga attatggtgg cggtggctcg
ggcggtggtg gatctggagg aggtgggagt 1560 gggaattctg acattgtgct
cacccaatct ccagcttctt tggctgtgtc tctaggtcag 1620 agagccacca
tctcctgcag agccagtgaa agtgttgaat attatgtcac aagtttaatg 1680
cagtggtacc aacagaaacc aggacagcca cccaaactcc tcatctctgc tgctagcaac
1740 gtagaatctg gggtccctgc caggtttagt ggcagtgggt ctgggacaga
ctttagcctc 1800 aacatccatc ctgtggagga ggatgatatt gcaatgtatt
tctgtcagca aagtaggaag 1860 gttccatgga cgttcggtgg aggcaccaag
ctggaaatca aacggggtgg cggtggatcc 1920 ggcggaggtg ggtcgggtgg
cggcggatct caggtgcagc tgaaggagtc aggacctggc 1980 ctggtggcgc
cctcacagag cctgtccatc acatgcaccg tctcagggtt ctcattaacc 2040
ggctatggtg taaactgggt tcgccagcct ccaggaaagg gtctggagtg gctgggaatg
2100 atatggggtg atggaagcac agactataat tcagctctca aatccagact
atcgatcacc 2160 aaggacaact ccaagagcca agttttctta aaaatgaaca
gtctgcaaac tgatgacaca 2220 gccagatact actgtgctcg agatggttat
agtaactttc attactatgt tatggactac 2280 tggggtcaag gaacctcagt
caccgtctcc tcttaatcta ga 2322 <210> SEQ ID NO 174 <211>
LENGTH: 767 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-STD1-2e12LH (w/2e12 leader) (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(22)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(128) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(519) <223> OTHER INFORMATION: EFD-BD2 linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (520)..(631) <223> OTHER INFORMATION: VL2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (632)..(646) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (647)..(767) <223> OTHER INFORMATION: VH2
<400> SEQUENCE: 174 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Ser Asp Ile
Val Leu Thr Gln Ser Pro Ala 515 520 525 Ser Leu Ala Val Ser Leu Gly
Gln Arg Ala Thr Ile Ser Cys Arg Ala 530 535 540 Ser Glu Ser Val Glu
Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln 545 550 555 560 Gln Lys
Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 565 570 575
Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 580
585 590 Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala
Met 595 600 605 Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe
Gly Gly Gly 610 615 620 Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly
Ser Gly Gly Gly Gly 625 630 635 640 Ser Gly Gly Gly Gly Ser Gln Val
Gln Leu Lys Glu Ser Gly Pro Gly 645 650 655 Leu Val Ala Pro Ser Gln
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 660 665 670 Phe Ser Leu Thr
Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly 675 680 685 Lys Gly
Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp 690 695 700
Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser 705
710 715 720 Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp
Asp Thr 725 730 735 Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn
Phe His Tyr Tyr 740 745 750 Val Met Asp Tyr Trp Gly Gln Gly Thr Ser
Val Thr Val Ser Ser 755 760 765 <210> SEQ ID NO 175
<211> LENGTH: 767 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: 2H7sssIgG1(P238S/P331S)-STD1-2e12LH (w/2e12 leader)
(AA) <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(22) <223> OTHER INFORMATION:
Leader <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (23)..(128) <223> OTHER INFORMATION: VL
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (129)..(144) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (145)..(265) <223> OTHER INFORMATION: VH
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (268)..(282) <223> OTHER INFORMATION: Hinge
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (500)..(519) <223> OTHER INFORMATION: EFD-BD2
Linker <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (520)..(631) <223> OTHER INFORMATION:
VL2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (632)..(646) <223> OTHER INFORMATION:
Linker2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (647)..(767) <223> OTHER INFORMATION:
VH2 <400> SEQUENCE: 175 Met Asp Phe Gln Val Gln Ile Phe Ser
Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln
Ile Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro
Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val
Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro
Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70
75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
Gln Gln Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser
Gly Ala Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met
His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195
200 205 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
Tyr 210 215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
Tyr Phe Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr
Trp Tyr Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val
Ser Asp Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser
Pro Pro Ser Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315
320 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
325 330 335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr 340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
Trp Leu Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Ser Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440
445 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
450 455 460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met 465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Ser
Asp Ile Val Leu Thr Gln Ser Pro Ala 515 520 525 Ser Leu Ala Val Ser
Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 530 535 540 Ser Glu Ser
Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln 545 550 555 560
Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 565
570 575 Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly
Thr 580 585 590 Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp
Ile Ala Met 595 600 605 Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp
Thr Phe Gly Gly Gly 610 615 620 Thr Lys Leu Glu Ile Lys Arg Gly Gly
Gly Gly Ser Gly Gly Gly Gly 625 630 635 640 Ser Gly Gly Gly Gly Ser
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 645 650 655 Leu Val Ala Pro
Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 660 665 670 Phe Ser
Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly 675 680 685
Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp 690
695 700 Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn
Ser 705 710 715 720 Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln
Thr Asp Asp Thr 725 730 735 Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr
Ser Asn Phe His Tyr Tyr 740 745 750 Val Met Asp Tyr Trp Gly Gln Gly
Thr Ser Val Thr Val Ser Ser 755 760 765 <210> SEQ ID NO 176
<211> LENGTH: 2376 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-STD2-2e12LH (DNA) <400>
SEQUENCE: 176 aagcttgccg ccatggattt tcaagtgcag attttcagct
tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc
tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat
gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga
agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct 240
tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc
300 agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag
ttttaaccca 360 cccacgttcg gtgctgggac caagctggag ctgaaagatg
gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct
tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa
gatgtcctgc aaggcttctg gctacacatt taccagttac 540 aatatgcact
gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat 600
ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta
660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga
agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat agtaactctt
actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat
caggagccca aatcttctga caaaactcac 840 acatccccac cgagcccagc
acctgaactc ctggggggac cgtcagtctt cctcttcccc 900 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 960
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa
acaatctcca aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc
tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1320
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc
1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa
cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc
agaagagcct ctccctgtct 1500 ccgggtaaga attatggtgg cggtggctcg
ggcggtggtg gatctggagg aggtgggagt 1560 gggaattatg gtggcggtgg
ctcgggcggt ggtggatctg gaggaggtgg gagtgggaat 1620 tctgacattg
tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc 1680
accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg
1740 taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag
caacgtagaa 1800 tctggggtcc ctgccaggtt tagtggcagt gggtctggga
cagactttag cctcaacatc 1860 catcctgtgg aggaggatga tattgcaatg
tatttctgtc agcaaagtag gaaggttcca 1920 tggacgttcg gtggaggcac
caagctggaa atcaaacggg gtggcggtgg atccggcgga 1980 ggtgggtcgg
gtggcggcgg atctcaggtg cagctgaagg agtcaggacc tggcctggtg 2040
gcgccctcac agagcctgtc catcacatgc accgtctcag ggttctcatt aaccggctat
2100 ggtgtaaact gggttcgcca gcctccagga aagggtctgg agtggctggg
aatgatatgg 2160 ggtgatggaa gcacagacta taattcagct ctcaaatcca
gactatcgat caccaaggac 2220 aactccaaga gccaagtttt cttaaaaatg
aacagtctgc aaactgatga cacagccaga 2280 tactactgtg ctcgagatgg
ttatagtaac tttcattact atgttatgga ctactggggt 2340 caaggaacct
cagtcaccgt ctcctcttaa tctaga 2376 <210> SEQ ID NO 177
<211> LENGTH: 785 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: 2H7sssIgG1-STD2-2e12LH (w/2e12 leader) <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1)..(22) <223> OTHER INFORMATION: Leader <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(129) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(130)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(537) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (538)..(649) <223> OTHER INFORMATION: VL2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (650)..(664) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (665)..(785) <223> OTHER INFORMATION: VH2
<400> SEQUENCE: 177 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Tyr Gly Gly
Gly Gly Ser Gly Gly Gly Gly 515 520 525 Ser Gly Gly Gly Gly Ser Gly
Asn Ser Asp Ile Val Leu Thr Gln Ser 530 535 540 Pro Ala Ser Leu Ala
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys 545 550 555 560 Arg Ala
Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp 565 570 575
Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala 580
585 590 Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly
Ser 595 600 605 Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu
Asp Asp Ile 610 615 620 Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val
Pro Trp Thr Phe Gly 625 630 635 640 Gly Gly Thr Lys Leu Glu Ile Lys
Arg Gly Gly Gly Gly Ser Gly Gly 645 650 655 Gly Gly Ser Gly Gly Gly
Gly Ser Gln Val Gln Leu Lys Glu Ser Gly 660 665 670 Pro Gly Leu Val
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val 675 680 685 Ser Gly
Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro 690 695 700
Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser 705
710 715 720 Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr
Lys Asp 725 730 735 Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser
Leu Gln Thr Asp 740 745 750 Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp
Gly Tyr Ser Asn Phe His 755 760 765 Tyr Tyr Val Met Asp Tyr Trp Gly
Gln Gly Thr Ser Val Thr Val Ser 770 775 780 Ser 785 <210> SEQ
ID NO 178 <211> LENGTH: 785 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1(P238S/P331S)-STD2-2e12LH (w/2e12
leader) (AA) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(22) <223> OTHER
INFORMATION: Leader <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (23)..(128) <223> OTHER
INFORMATION: VL <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (129)..(144) <223> OTHER
INFORMATION: Linker <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (145)..(265) <223> OTHER
INFORMATION: VH <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (268)..(281) <223> OTHER
INFORMATION: Hinge <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (500)..(537) <223> OTHER
INFORMATION: EFD-BD2 Linker <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (538)..(649)
<223> OTHER INFORMATION: VL2 <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (650)..(664)
<223> OTHER INFORMATION: Linker2 <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(665)..(785) <223> OTHER INFORMATION: VH2 <400>
SEQUENCE: 178 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile
Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser
Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly Glu Lys Val
Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser Tyr Met His
Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys Pro Trp Ile
Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80 Ala Arg Phe
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85 90 95 Ser
Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 100 105
110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val
Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp Val Lys Gln
Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala Ile Tyr Pro
Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205 Lys Gly Lys
Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210 215 220 Met
Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 225 230
235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val
Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro
Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro Ser Ser Ala
Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330 335 His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 340 345 350
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 355
360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser
Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455 460 Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 465 470 475
480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Tyr Gly Gly Gly Gly Ser
Gly Gly Gly Gly 515 520 525 Ser Gly Gly Gly Gly Ser Gly Asn Ser Asp
Ile Val Leu Thr Gln Ser 530 535 540 Pro Ala Ser Leu Ala Val Ser Leu
Gly Gln Arg Ala Thr Ile Ser Cys 545 550 555 560 Arg Ala Ser Glu Ser
Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp 565 570 575 Tyr Gln Gln
Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala 580 585 590 Ser
Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 595 600
605 Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile
610 615 620 Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr
Phe Gly 625 630 635 640 Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly
Gly Gly Ser Gly Gly 645 650 655 Gly Gly Ser Gly Gly Gly Gly Ser Gln
Val Gln Leu Lys Glu Ser Gly 660 665 670 Pro Gly Leu Val Ala Pro Ser
Gln Ser Leu Ser Ile Thr Cys Thr Val 675 680 685 Ser Gly Phe Ser Leu
Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro 690 695 700 Pro Gly Lys
Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser 705 710 715 720
Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp 725
730 735 Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr
Asp 740 745 750 Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser
Asn Phe His 755 760 765 Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr
Ser Val Thr Val Ser 770 775 780 Ser 785 <210> SEQ ID NO 179
<211> LENGTH: 2391 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-STD2-2e12HL (DNA) <400>
SEQUENCE: 179 aagcttgccg ccatggattt tcaagtgcag attttcagct
tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc
tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat
gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga
agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct 240
tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc
300 agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag
ttttaaccca 360 cccacgttcg gtgctgggac caagctggag ctgaaagatg
gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct
tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa
gatgtcctgc aaggcttctg gctacacatt taccagttac 540 aatatgcact
gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat 600
ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta
660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga
agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat agtaactctt
actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat
caggagccca aatcttctga caaaactcac 840 acatccccac cgagcccagc
acctgaactc ctggggggac cgtcagtctt cctcttcccc 900 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 960
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa
acaatctcca aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc
tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1320
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc
1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa
cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc
agaagagcct ctccctgtct 1500 ccgggtaaga attatggtgg cggtggctcg
ggcggtggtg gatctggagg aggtgggagt 1560 gggaattatg gtggcggtgg
ctcgggcggt ggtggatctg gaggaggtgg gagtgggaat 1620 tctcaggtgc
agctgaagga gtcaggacct ggcctggtgg cgccctcaca gagcctgtcc 1680
atcacatgca ccgtctcagg gttctcatta accggctatg gtgtaaactg ggttcgccag
1740 cctccaggaa agggtctgga gtggctggga atgatatggg gtgatggaag
cacagactat 1800 aattcagctc tcaaatccag actatcgatc accaaggaca
actccaagag ccaagttttc 1860 ttaaaaatga acagtctgca aactgatgac
acagccagat actactgtgc tcgagatggt 1920 tatagtaact ttcattacta
tgttatggac tactggggtc aaggaacctc agtcaccgtc 1980 tcctctgggg
gtggaggctc tggtggcggt ggatccggcg gaggtgggtc gggtggcggc 2040
ggatctgaca ttgtgctcac ccaatctcca gcttctttgg ctgtgtctct aggtcagaga
2100 gccaccatct cctgcagagc cagtgaaagt gttgaatatt atgtcacaag
tttaatgcag 2160 tggtaccaac agaaaccagg acagccaccc aaactcctca
tctctgctgc tagcaacgta 2220 gaatctgggg tccctgccag gtttagtggc
agtgggtctg ggacagactt tagcctcaac 2280 atccatcctg tggaggagga
tgatattgca atgtatttct gtcagcaaag taggaaggtt 2340 ccatggacgt
tcggtggagg caccaagctg gaaatcaaac gttaatctag a 2391 <210> SEQ
ID NO 180 <211> LENGTH: 790 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-STD2-2e12HL (w/2e12 leader) (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(22) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (23)..(128) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(537) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (538)..(658) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (659)..(678) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (679)..(790) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 180 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Tyr Gly Gly
Gly Gly Ser Gly Gly Gly Gly 515 520 525 Ser Gly Gly Gly Gly Ser Gly
Asn Ser Gln Val Gln Leu Lys Glu Ser 530 535 540 Gly Pro Gly Leu Val
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr 545 550 555 560 Val Ser
Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln 565 570 575
Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly 580
585 590 Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr
Lys 595 600 605 Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser
Leu Gln Thr 610 615 620 Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp
Gly Tyr Ser Asn Phe 625 630 635 640 His Tyr Tyr Val Met Asp Tyr Trp
Gly Gln Gly Thr Ser Val Thr Val 645 650 655 Ser Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 660 665 670 Ser Gly Gly Gly
Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 675 680 685 Leu Ala
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 690 695 700
Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln 705
710 715 720 Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser
Asn Val 725 730 735 Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly
Ser Gly Thr Asp 740 745 750 Phe Ser Leu Asn Ile His Pro Val Glu Glu
Asp Asp Ile Ala Met Tyr 755 760 765 Phe Cys Gln Gln Ser Arg Lys Val
Pro Trp Thr Phe Gly Gly Gly Thr 770 775 780 Lys Leu Glu Ile Lys Arg
785 790 <210> SEQ ID NO 181 <211> LENGTH: 790
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1(P238S/P331S)-STD2-2e12HL (w/2e12 leader) (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(22) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (23)..(128) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(537) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (538)..(658) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (659)..(678) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (679)..(790) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 181 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Ser Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Tyr Gly Gly
Gly Gly Ser Gly Gly Gly Gly 515 520 525 Ser Gly Gly Gly Gly Ser Gly
Asn Ser Gln Val Gln Leu Lys Glu Ser 530 535 540 Gly Pro Gly Leu Val
Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr 545 550 555 560 Val Ser
Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln 565 570 575
Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly 580
585 590 Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr
Lys 595 600 605 Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser
Leu Gln Thr 610 615 620 Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp
Gly Tyr Ser Asn Phe 625 630 635 640 His Tyr Tyr Val Met Asp Tyr Trp
Gly Gln Gly Thr Ser Val Thr Val 645 650 655 Ser Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 660 665 670 Ser Gly Gly Gly
Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 675 680 685 Leu Ala
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 690 695 700
Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln 705
710 715 720 Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser
Asn Val 725 730 735 Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly
Ser Gly Thr Asp 740 745 750 Phe Ser Leu Asn Ile His Pro Val Glu Glu
Asp Asp Ile Ala Met Tyr 755 760 765 Phe Cys Gln Gln Ser Arg Lys Val
Pro Trp Thr Phe Gly Gly Gly Thr 770 775 780 Lys Leu Glu Ile Lys Arg
785 790 <210> SEQ ID NO 182 <211> LENGTH: 2283
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H1-2e12HL (DNA) <400> SEQUENCE: 182 aagcttgccg
ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca 60
gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct
120 ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta
catgcactgg 180 taccagcaga agccaggatc ctcccccaaa ccctggattt
atgccccatc caacctggct 240 tctggagtcc ctgctcgctt cagtggcagt
gggtctggga cctcttactc tctcacaatc 300 agcagagtgg aggctgaaga
tgctgccact tattactgcc agcagtggag ttttaaccca 360 cccacgttcg
gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt 420
ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg
480 aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt
taccagttac 540 aatatgcact gggtaaagca gacacctaga cagggcctgg
aatggattgg agctatttat 600 ccaggaaatg gtgatacttc ctacaatcag
aagttcaagg gcaaggccac actgactgta 660 gacaaatcct ccagcacagc
ctacatgcag ctcagcagcc tgacatctga agactctgcg 720 gtctatttct
gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg 780
ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac
840 acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt
cctcttcccc 900 ccaaaaccca aggacaccct catgatctcc cggacccctg
aggtcacatg cgtggtggtg 960 gacgtgagcc acgaagaccc tgaggtcaag
ttcaactggt acgtggacgg cgtggaggtg 1020 cataatgcca agacaaagcc
gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 1080 gtcctcaccg
tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc 1140
aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga
1200 gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa
ccaggtcagc 1260 ctgacctgcc tggtcaaagg cttctatccc agcgacatcg
ccgtggagtg ggagagcaat 1320 gggcagccgg agaacaacta caagaccacg
cctcccgtgc tggactccga cggctccttc 1380 ttcctctaca gcaagctcac
cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1440 tgctccgtga
tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 1500
ccgggtaaga attctcaggt gcagctgaag gagtcaggac ctggcctggt ggcgccctca
1560 cagagcctgt ccatcacatg caccgtctca gggttctcat taaccggcta
tggtgtaaac 1620 tgggttcgcc agcctccagg aaagggtctg gagtggctgg
gaatgatatg gggtgatgga 1680 agcacagact ataattcagc tctcaaatcc
agactatcga tcaccaagga caactccaag 1740 agccaagttt tcttaaaaat
gaacagtctg caaactgatg acacagccag atactactgt 1800 gctcgagatg
gttatagtaa ctttcattac tatgttatgg actactgggg tcaaggaacc 1860
tcagtcaccg tctcctctgg gggtggaggc tctggtggcg gtggatccgg cggaggtggg
1920 tcgggtggcg gcggatctga cattgtgctc acccaatctc cagcttcttt
ggctgtgtct 1980 ctaggtcaga gagccaccat ctcctgcaga gccagtgaaa
gtgttgaata ttatgtcaca 2040 agtttaatgc agtggtacca acagaaacca
ggacagccac ccaaactcct catctctgct 2100 gctagcaacg tagaatctgg
ggtccctgcc aggtttagtg gcagtgggtc tgggacagac 2160 tttagcctca
acatccatcc tgtggaggag gatgatattg caatgtattt ctgtcagcaa 2220
agtaggaagg ttccatggac gttcggtgga ggcaccaagc tggaaatcaa acgttaatct
2280 aga 2283 <210> SEQ ID NO 183 <211> LENGTH: 754
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H1-2e12HL (w/2e12 leader) (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(22)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(128) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(281) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(501) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (502)..(622) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (623)..(642) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (643)..(754) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 183 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Pro Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Asn Ser Gln Val Gln Leu Lys Glu
Ser Gly Pro Gly Leu 500 505 510 Val Ala Pro Ser Gln Ser Leu Ser Ile
Thr Cys Thr Val Ser Gly Phe 515 520 525 Ser Leu Thr Gly Tyr Gly Val
Asn Trp Val Arg Gln Pro Pro Gly Lys 530 535 540 Gly Leu Glu Trp Leu
Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr 545 550 555 560 Asn Ser
Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys 565 570 575
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 580
585 590 Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr
Val 595 600 605 Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser
Ser Gly Gly 610 615 620 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly 625 630 635 640 Gly Ser Asp Ile Val Leu Thr Gln
Ser Pro Ala Ser Leu Ala Val Ser 645 650 655 Leu Gly Gln Arg Ala Thr
Ile Ser Cys Arg Ala Ser Glu Ser Val Glu 660 665 670 Tyr Tyr Val Thr
Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln 675 680 685 Pro Pro
Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val 690 695 700
Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn 705
710 715 720 Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys
Gln Gln 725 730 735 Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile 740 745 750 Lys Arg <210> SEQ ID NO 184
<211> LENGTH: 2301 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-H2-2e12HL (DNA) <400> SEQUENCE:
184 aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat
cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc tcccagtctc
cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat gacttgcagg
gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga agccaggatc
ctcccccaaa ccctggattt atgccccatc caacctggct 240 tctggagtcc
ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc 300
agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca
360 cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc
gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct tatctacagc
agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa gatgtcctgc
aaggcttctg gctacacatt taccagttac 540 aatatgcact gggtaaagca
gacacctaga cagggcctgg aatggattgg agctatttat 600 ccaggaaatg
gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta 660
gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg
720 gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt
cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat caggagccca
aatcttctga caaaactcac 840 acatccccac cgagcccagc acctgaactc
ctggggggac cgtcagtctt cctcttcccc 900 ccaaaaccca aggacaccct
catgatctcc cggacccctg aggtcacatg cgtggtggtg 960 gacgtgagcc
acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 1020
cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc
1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg
caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa acaatctcca
aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct gcccccatcc
cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc tggtcaaagg
cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1320 gggcagccgg
agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc 1380
ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca
1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct
ctccctgtct 1500 ccgggtaagg gtggcggtgg ctcggggaat tctcaggtgc
agctgaagga gtcaggacct 1560 ggcctggtgg cgccctcaca gagcctgtcc
atcacatgca ccgtctcagg gttctcatta 1620 accggctatg gtgtaaactg
ggttcgccag cctccaggaa agggtctgga gtggctggga 1680 atgatatggg
gtgatggaag cacagactat aattcagctc tcaaatccag actatcgatc 1740
accaaggaca actccaagag ccaagttttc ttaaaaatga acagtctgca aactgatgac
1800 acagccagat actactgtgc tcgagatggt tatagtaact ttcattacta
tgttatggac 1860 tactggggtc aaggaacctc agtcaccgtc tcctctgggg
gtggaggctc tggtggcggt 1920 ggatccggcg gaggtgggtc gggtggcggc
ggatctgaca ttgtgctcac ccaatctcca 1980 gcttctttgg ctgtgtctct
aggtcagaga gccaccatct cctgcagagc cagtgaaagt 2040 gttgaatatt
atgtcacaag tttaatgcag tggtaccaac agaaaccagg acagccaccc 2100
aaactcctca tctctgctgc tagcaacgta gaatctgggg tccctgccag gtttagtggc
2160 agtgggtctg ggacagactt tagcctcaac atccatcctg tggaggagga
tgatattgca 2220 atgtatttct gtcagcaaag taggaaggtt ccatggacgt
tcggtggagg caccaagctg 2280 gaaatcaaac gttaatctag a 2301 <210>
SEQ ID NO 185 <211> LENGTH: 760 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sssIgG1-H2-2e12HL (w/2e12 leader)
(AA) <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(22) <223> OTHER INFORMATION:
Leader <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (23)..(127) <223> OTHER INFORMATION: VL
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (128)..(144) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (145)..(265) <223> OTHER INFORMATION: VH
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (268)..(282) <223> OTHER INFORMATION: Hinge
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (500)..(507) <223> OTHER INFORMATION: EFD-BD2
Linker <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (508)..(628) <223> OTHER INFORMATION:
VH2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (629)..(648) <223> OTHER INFORMATION:
Linker2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (649)..(760) <223> OTHER INFORMATION:
VL2 <400> SEQUENCE: 185 Met Asp Phe Gln Val Gln Ile Phe Ser
Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln
Ile Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro
Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val
Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro
Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70
75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
Gln Gln Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser
Gly Ala Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met
His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195
200 205 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
Tyr 210 215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
Tyr Phe Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr
Trp Tyr Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val
Ser Asp Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser
Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315
320 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
325 330 335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr 340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
Trp Leu Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440
445 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
450 455 460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met 465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser 485 490 495 Pro Gly Lys Gly Gly Gly Gly Ser Gly
Asn Ser Gln Val Gln Leu Lys 500 505 510 Glu Ser Gly Pro Gly Leu Val
Ala Pro Ser Gln Ser Leu Ser Ile Thr 515 520 525 Cys Thr Val Ser Gly
Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val 530 535 540 Arg Gln Pro
Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly 545 550 555 560
Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile 565
570 575 Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser
Leu 580 585 590 Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp
Gly Tyr Ser 595 600 605 Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly
Gln Gly Thr Ser Val 610 615 620 Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly 625 630 635 640 Gly Gly Ser Gly Gly Gly
Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 645 650 655 Ala Ser Leu Ala
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 660 665 670 Ala Ser
Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr 675 680 685
Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser 690
695 700 Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser
Gly 705 710 715 720 Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu
Asp Asp Ile Ala 725 730 735 Met Tyr Phe Cys Gln Gln Ser Arg Lys Val
Pro Trp Thr Phe Gly Gly 740 745 750 Gly Thr Lys Leu Glu Ile Lys Arg
755 760 <210> SEQ ID NO 186 <211> LENGTH: 2307
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H3-2e12HL (DNA) <400> SEQUENCE: 186 aagcttgccg
ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca 60
gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct
120 ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta
catgcactgg 180 taccagcaga agccaggatc ctcccccaaa ccctggattt
atgccccatc caacctggct 240 tctggagtcc ctgctcgctt cagtggcagt
gggtctggga cctcttactc tctcacaatc 300 agcagagtgg aggctgaaga
tgctgccact tattactgcc agcagtggag ttttaaccca 360 cccacgttcg
gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt 420
ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg
480 aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt
taccagttac 540 aatatgcact gggtaaagca gacacctaga cagggcctgg
aatggattgg agctatttat 600 ccaggaaatg gtgatacttc ctacaatcag
aagttcaagg gcaaggccac actgactgta 660 gacaaatcct ccagcacagc
ctacatgcag ctcagcagcc tgacatctga agactctgcg 720 gtctatttct
gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg 780
ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac
840 acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt
cctcttcccc 900 ccaaaaccca aggacaccct catgatctcc cggacccctg
aggtcacatg cgtggtggtg 960 gacgtgagcc acgaagaccc tgaggtcaag
ttcaactggt acgtggacgg cgtggaggtg 1020 cataatgcca agacaaagcc
gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 1080 gtcctcaccg
tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc 1140
aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga
1200 gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa
ccaggtcagc 1260 ctgacctgcc tggtcaaagg cttctatccc agcgacatcg
ccgtggagtg ggagagcaat 1320 gggcagccgg agaacaacta caagaccacg
cctcccgtgc tggactccga cggctccttc 1380 ttcctctaca gcaagctcac
cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1440 tgctccgtga
tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 1500
ccgggtaaga attatggtgg cggtggctct gggaattctc aggtgcagct gaaggagtca
1560 ggacctggcc tggtggcgcc ctcacagagc ctgtccatca catgcaccgt
ctcagggttc 1620 tcattaaccg gctatggtgt aaactgggtt cgccagcctc
caggaaaggg tctggagtgg 1680 ctgggaatga tatggggtga tggaagcaca
gactataatt cagctctcaa atccagacta 1740 tcgatcacca aggacaactc
caagagccaa gttttcttaa aaatgaacag tctgcaaact 1800 gatgacacag
ccagatacta ctgtgctcga gatggttata gtaactttca ttactatgtt 1860
atggactact ggggtcaagg aacctcagtc accgtctcct ctgggggtgg aggctctggt
1920 ggcggtggat ccggcggagg tgggtcgggt ggcggcggat ctgacattgt
gctcacccaa 1980 tctccagctt ctttggctgt gtctctaggt cagagagcca
ccatctcctg cagagccagt 2040 gaaagtgttg aatattatgt cacaagttta
atgcagtggt accaacagaa accaggacag 2100 ccacccaaac tcctcatctc
tgctgctagc aacgtagaat ctggggtccc tgccaggttt 2160 agtggcagtg
ggtctgggac agactttagc ctcaacatcc atcctgtgga ggaggatgat 2220
attgcaatgt atttctgtca gcaaagtagg aaggttccat ggacgttcgg tggaggcacc
2280 aagctggaaa tcaaacgtta atctaga 2307 <210> SEQ ID NO 187
<211> LENGTH: 762 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: 2H7sssIgG1-H3-2e12HL (w/2e12 leader) (AA) <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1)..(22) <223> OTHER INFORMATION: Leader <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(128) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(509) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (510)..(630) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (631)..(650) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (651)..(762) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 187 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Pro Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly
Asn Ser Gln Val Gln 500 505 510 Leu Lys Glu Ser Gly Pro Gly Leu Val
Ala Pro Ser Gln Ser Leu Ser 515 520 525 Ile Thr Cys Thr Val Ser Gly
Phe Ser Leu Thr Gly Tyr Gly Val Asn 530 535 540 Trp Val Arg Gln Pro
Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile 545 550 555 560 Trp Gly
Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu 565 570 575
Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 580
585 590 Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp
Gly 595 600 605 Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly
Gln Gly Thr 610 615 620 Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 625 630 635 640 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Asp Ile Val Leu Thr Gln 645 650 655 Ser Pro Ala Ser Leu Ala
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 660 665 670 Cys Arg Ala Ser
Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln 675 680 685 Trp Tyr
Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala 690 695 700
Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 705
710 715 720 Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu
Asp Asp 725 730 735 Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val
Pro Trp Thr Phe 740 745 750 Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
755 760 <210> SEQ ID NO 188 <211> LENGTH: 2316
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H4-2e12HL (DNA) <400> SEQUENCE: 188 aagcttgccg
ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca 60
gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct
120 ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta
catgcactgg 180 taccagcaga agccaggatc ctcccccaaa ccctggattt
atgccccatc caacctggct 240 tctggagtcc ctgctcgctt cagtggcagt
gggtctggga cctcttactc tctcacaatc 300 agcagagtgg aggctgaaga
tgctgccact tattactgcc agcagtggag ttttaaccca 360 cccacgttcg
gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt 420
ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg
480 aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt
taccagttac 540 aatatgcact gggtaaagca gacacctaga cagggcctgg
aatggattgg agctatttat 600 ccaggaaatg gtgatacttc ctacaatcag
aagttcaagg gcaaggccac actgactgta 660 gacaaatcct ccagcacagc
ctacatgcag ctcagcagcc tgacatctga agactctgcg 720 gtctatttct
gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg 780
ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac
840 acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt
cctcttcccc 900 ccaaaaccca aggacaccct catgatctcc cggacccctg
aggtcacatg cgtggtggtg 960 gacgtgagcc acgaagaccc tgaggtcaag
ttcaactggt acgtggacgg cgtggaggtg 1020 cataatgcca agacaaagcc
gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 1080 gtcctcaccg
tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc 1140
aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga
1200 gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa
ccaggtcagc 1260 ctgacctgcc tggtcaaagg cttctatccc agcgacatcg
ccgtggagtg ggagagcaat 1320 gggcagccgg agaacaacta caagaccacg
cctcccgtgc tggactccga cggctccttc 1380 ttcctctaca gcaagctcac
cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1440 tgctccgtga
tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 1500
ccgggtaagg gtggcggtgg ctcgggcggt ggtggatctg ggaattctca ggtgcagctg
1560 aaggagtcag gacctggcct ggtggcgccc tcacagagcc tgtccatcac
atgcaccgtc 1620 tcagggttct cattaaccgg ctatggtgta aactgggttc
gccagcctcc aggaaagggt 1680 ctggagtggc tgggaatgat atggggtgat
ggaagcacag actataattc agctctcaaa 1740 tccagactat cgatcaccaa
ggacaactcc aagagccaag ttttcttaaa aatgaacagt 1800 ctgcaaactg
atgacacagc cagatactac tgtgctcgag atggttatag taactttcat 1860
tactatgtta tggactactg gggtcaagga acctcagtca ccgtctcctc tgggggtgga
1920 ggctctggtg gcggtggatc cggcggaggt gggtcgggtg gcggcggatc
tgacattgtg 1980 ctcacccaat ctccagcttc tttggctgtg tctctaggtc
agagagccac catctcctgc 2040 agagccagtg aaagtgttga atattatgtc
acaagtttaa tgcagtggta ccaacagaaa 2100 ccaggacagc cacccaaact
cctcatctct gctgctagca acgtagaatc tggggtccct 2160 gccaggttta
gtggcagtgg gtctgggaca gactttagcc tcaacatcca tcctgtggag 2220
gaggatgata ttgcaatgta tttctgtcag caaagtagga aggttccatg gacgttcggt
2280 ggaggcacca agctggaaat caaacgttaa tctaga 2316 <210> SEQ
ID NO 189 <211> LENGTH: 765 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-H4-2e12HL (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(22)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(128) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(512) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (513)..(633) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (634)..(653) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (654)..(765) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 189 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Pro Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Asn Ser 500 505 510 Gln Val Gln Leu Lys Glu Ser Gly Pro
Gly Leu Val Ala Pro Ser Gln 515 520 525 Ser Leu Ser Ile Thr Cys Thr
Val Ser Gly Phe Ser Leu Thr Gly Tyr 530 535 540 Gly Val Asn Trp Val
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 545 550 555 560 Gly Met
Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 565 570 575
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 580
585 590 Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys
Ala 595 600 605 Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp
Tyr Trp Gly 610 615 620 Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly 625 630 635 640 Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Asp Ile Val 645 650 655 Leu Thr Gln Ser Pro Ala
Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 660 665 670 Thr Ile Ser Cys
Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser 675 680 685 Leu Met
Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 690 695 700
Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser 705
710 715 720 Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro
Val Glu 725 730 735 Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
Arg Lys Val Pro 740 745 750 Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu
Ile Lys Arg 755 760 765 <210> SEQ ID NO 190 <211>
LENGTH: 2322 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H5-2e12HL (DNA) <400> SEQUENCE: 190 aagcttgccg
ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca 60
gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct
120 ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta
catgcactgg 180 taccagcaga agccaggatc ctcccccaaa ccctggattt
atgccccatc caacctggct 240 tctggagtcc ctgctcgctt cagtggcagt
gggtctggga cctcttactc tctcacaatc 300 agcagagtgg aggctgaaga
tgctgccact tattactgcc agcagtggag ttttaaccca 360 cccacgttcg
gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt 420
ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg
480 aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt
taccagttac 540 aatatgcact gggtaaagca gacacctaga cagggcctgg
aatggattgg agctatttat 600 ccaggaaatg gtgatacttc ctacaatcag
aagttcaagg gcaaggccac actgactgta 660 gacaaatcct ccagcacagc
ctacatgcag ctcagcagcc tgacatctga agactctgcg 720 gtctatttct
gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg 780
ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac
840 acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt
cctcttcccc 900 ccaaaaccca aggacaccct catgatctcc cggacccctg
aggtcacatg cgtggtggtg 960 gacgtgagcc acgaagaccc tgaggtcaag
ttcaactggt acgtggacgg cgtggaggtg 1020 cataatgcca agacaaagcc
gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 1080 gtcctcaccg
tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc 1140
aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga
1200 gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa
ccaggtcagc 1260 ctgacctgcc tggtcaaagg cttctatccc agcgacatcg
ccgtggagtg ggagagcaat 1320 gggcagccgg agaacaacta caagaccacg
cctcccgtgc tggactccga cggctccttc 1380 ttcctctaca gcaagctcac
cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1440 tgctccgtga
tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 1500
ccgggtaaga attatggtgg cggtggctcg ggcggtggtg gatctgggaa ttctcaggtg
1560 cagctgaagg agtcaggacc tggcctggtg gcgccctcac agagcctgtc
catcacatgc 1620 accgtctcag ggttctcatt aaccggctat ggtgtaaact
gggttcgcca gcctccagga 1680 aagggtctgg agtggctggg aatgatatgg
ggtgatggaa gcacagacta taattcagct 1740 ctcaaatcca gactatcgat
caccaaggac aactccaaga gccaagtttt cttaaaaatg 1800 aacagtctgc
aaactgatga cacagccaga tactactgtg ctcgagatgg ttatagtaac 1860
tttcattact atgttatgga ctactggggt caaggaacct cagtcaccgt ctcctctggg
1920 ggtggaggct ctggtggcgg tggatccggc ggaggtgggt cgggtggcgg
cggatctgac 1980 attgtgctca cccaatctcc agcttctttg gctgtgtctc
taggtcagag agccaccatc 2040 tcctgcagag ccagtgaaag tgttgaatat
tatgtcacaa gtttaatgca gtggtaccaa 2100 cagaaaccag gacagccacc
caaactcctc atctctgctg ctagcaacgt agaatctggg 2160 gtccctgcca
ggtttagtgg cagtgggtct gggacagact ttagcctcaa catccatcct 2220
gtggaggagg atgatattgc aatgtatttc tgtcagcaaa gtaggaaggt tccatggacg
2280 ttcggtggag gcaccaagct ggaaatcaaa cgttaatcta ga 2322
<210> SEQ ID NO 191 <211> LENGTH: 767 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sssIgG1-H5-2e12HL (w/2e12 leader)
(AA) <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(22) <223> OTHER INFORMATION:
Leader <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (23)..(128) <223> OTHER INFORMATION: VL
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (129)..(144) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (145)..(265) <223> OTHER INFORMATION: VH
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (268)..(282) <223> OTHER INFORMATION: Hinge
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (500)..(514) <223> OTHER INFORMATION: EFD-BD2
Linker <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (515)..(635) <223> OTHER INFORMATION:
VH2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (636)..(655) <223> OTHER INFORMATION:
Linker2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (656)..(767) <223> OTHER INFORMATION:
VL2 <400> SEQUENCE: 191 Met Asp Phe Gln Val Gln Ile Phe Ser
Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln
Ile Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro
Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val
Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro
Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70
75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
Gln Gln Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser
Gly Ala Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met
His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195
200 205 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
Tyr 210 215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
Tyr Phe Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr
Trp Tyr Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val
Ser Asp Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser
Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315
320 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
325 330 335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr 340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
Trp Leu Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440
445 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
450 455 460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met 465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly 500 505 510 Asn Ser Gln Val Gln Leu Lys
Glu Ser Gly Pro Gly Leu Val Ala Pro 515 520 525 Ser Gln Ser Leu Ser
Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 530 535 540 Gly Tyr Gly
Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 545 550 555 560
Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala 565
570 575 Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln
Val 580 585 590 Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala
Arg Tyr Tyr 595 600 605 Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr
Tyr Val Met Asp Tyr 610 615 620 Trp Gly Gln Gly Thr Ser Val Thr Val
Ser Ser Gly Gly Gly Gly Ser 625 630 635 640 Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 645 650 655 Ile Val Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 660 665 670 Arg Ala
Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val 675 680 685
Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 690
695 700 Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala
Arg 705 710 715 720 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu
Asn Ile His Pro 725 730 735 Val Glu Glu Asp Asp Ile Ala Met Tyr Phe
Cys Gln Gln Ser Arg Lys 740 745 750 Val Pro Trp Thr Phe Gly Gly Gly
Thr Lys Leu Glu Ile Lys Arg 755 760 765 <210> SEQ ID NO 192
<211> LENGTH: 2331 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-H6-2e12HL (DNA) <400> SEQUENCE:
192 aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat
cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc tcccagtctc
cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat gacttgcagg
gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga agccaggatc
ctcccccaaa ccctggattt atgccccatc caacctggct 240 tctggagtcc
ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc 300
agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca
360 cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc
gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct tatctacagc
agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa gatgtcctgc
aaggcttctg gctacacatt taccagttac 540 aatatgcact gggtaaagca
gacacctaga cagggcctgg aatggattgg agctatttat 600 ccaggaaatg
gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta 660
gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg
720 gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt
cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat caggagccca
aatcttctga caaaactcac 840 acatccccac cgagcccagc acctgaactc
ctggggggac cgtcagtctt cctcttcccc 900 ccaaaaccca aggacaccct
catgatctcc cggacccctg aggtcacatg cgtggtggtg 960 gacgtgagcc
acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 1020
cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc
1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg
caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa acaatctcca
aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct gcccccatcc
cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc tggtcaaagg
cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1320 gggcagccgg
agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc 1380
ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca
1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct
ctccctgtct 1500 ccgggtaagg gtggcggtgg ctcgggcggt ggtggatctg
ggggaggagg cagcgggaat 1560 tctcaggtgc agctgaagga gtcaggacct
ggcctggtgg cgccctcaca gagcctgtcc 1620 atcacatgca ccgtctcagg
gttctcatta accggctatg gtgtaaactg ggttcgccag 1680 cctccaggaa
agggtctgga gtggctggga atgatatggg gtgatggaag cacagactat 1740
aattcagctc tcaaatccag actatcgatc accaaggaca actccaagag ccaagttttc
1800 ttaaaaatga acagtctgca aactgatgac acagccagat actactgtgc
tcgagatggt 1860 tatagtaact ttcattacta tgttatggac tactggggtc
aaggaacctc agtcaccgtc 1920 tcctctgggg gtggaggctc tggtggcggt
ggatccggcg gaggtgggtc gggtggcggc 1980 ggatctgaca ttgtgctcac
ccaatctcca gcttctttgg ctgtgtctct aggtcagaga 2040 gccaccatct
cctgcagagc cagtgaaagt gttgaatatt atgtcacaag tttaatgcag 2100
tggtaccaac agaaaccagg acagccaccc aaactcctca tctctgctgc tagcaacgta
2160 gaatctgggg tccctgccag gtttagtggc agtgggtctg ggacagactt
tagcctcaac 2220 atccatcctg tggaggagga tgatattgca atgtatttct
gtcagcaaag taggaaggtt 2280 ccatggacgt tcggtggagg caccaagctg
gaaatcaaac gttaatctag a 2331 <210> SEQ ID NO 193 <211>
LENGTH: 770 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H6-2e12HL (w/2e12 leader) (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(22)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(128) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(517) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (518)..(638) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (639)..(658) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (659)..(770) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 193 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Pro Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly 500 505 510 Gly Ser Gly Asn Ser Gln Val Gln Leu
Lys Glu Ser Gly Pro Gly Leu 515 520 525 Val Ala Pro Ser Gln Ser Leu
Ser Ile Thr Cys Thr Val Ser Gly Phe 530 535 540 Ser Leu Thr Gly Tyr
Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys 545 550 555 560 Gly Leu
Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr 565 570 575
Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys 580
585 590 Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr
Ala 595 600 605 Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His
Tyr Tyr Val 610 615 620 Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr
Val Ser Ser Gly Gly 625 630 635 640 Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly 645 650 655 Gly Ser Asp Ile Val Leu
Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 660 665 670 Leu Gly Gln Arg
Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu 675 680 685 Tyr Tyr
Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln 690 695 700
Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val 705
710 715 720 Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser
Leu Asn 725 730 735 Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr
Phe Cys Gln Gln 740 745 750 Ser Arg Lys Val Pro Trp Thr Phe Gly Gly
Gly Thr Lys Leu Glu Ile 755 760 765 Lys Arg 770 <210> SEQ ID
NO 194 <211> LENGTH: 2301 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sscIgG1-H7-2e12HL (DNA) <400> SEQUENCE:
194 aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat
cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc tcccagtctc
cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat gacttgcagg
gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga agccaggatc
ctcccccaaa ccctggattt atgccccatc caacctggct 240 tctggagtcc
ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc 300
agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca
360 cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc
gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct tatctacagc
agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa gatgtcctgc
aaggcttctg gctacacatt taccagttac 540 aatatgcact gggtaaagca
gacacctaga cagggcctgg aatggattgg agctatttat 600 ccaggaaatg
gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta 660
gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg
720 gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt
cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat caggagccca
aatcttctga caaaactcac 840 acatccccac cgtgcccagc acctgaactc
ctggggggat cgtcagtctt cctcttcccc 900 ccaaaaccca aggacaccct
catgatctcc cggacccctg aggtcacatg cgtggtggtg 960 gacgtgagcc
acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 1020
cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc
1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg
caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa accatctcca
aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct gcccccatcc
cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc tggtcaaagg
cttctatcca agcgacatcg ccgtggagtg ggagagcaat 1320 gggcagccgg
agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc 1380
ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca
1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct
ctccctgtct 1500 ccgggtaagg ggtgtccacc ttgtccgaat tctcaggtgc
agctgaagga gtcagggcct 1560 ggcagcgtgg cgccctcaca gagcctgtcc
atcacatgca ccgtctcagg gttctcatta 1620 accggctatg gtgtaaactg
ggttcgccag cctccaggaa agggtctgga gtggctggga 1680 atgatatggg
gtgatggaag cacagactat aattcagctc tcaaatccag actatcgatc 1740
accaaggaca actccaagag ccaagttttc ttaaaaatga acagtctgca aactgatgac
1800 acagccagat actactgtgc tcgagatggt tatagtaact ttcattacta
tgttatggac 1860 tactggggtc aaggaacctc agtcaccgtc tcctctgggg
gtggaggctc tggtggcggt 1920 ggatccggcg gaggtgggtc gggtggcggc
ggatctgaca ttgtgctcac ccaatctcca 1980 gcttctttgg ctgtgtctct
aggtcagaga gccaccatct cctgcagagc cagtgaaagt 2040 gttgaatatt
atgtcacaag tttaatgcag tggtaccaac agaaaccagg acagccaccc 2100
aagctcctca tctctgctgc tagcaacgta gaatctgggg tccctgccag gtttagtggc
2160 agtgggtctg ggacagactt tagcctcaac atccatcctg tggaggagga
tgatattgca 2220 atgtatttct gtcagcaaag taggaaggtt ccatggacgt
tcggtggagg caccaagctg 2280 gaaatcaaac gttaatctag a 2301 <210>
SEQ ID NO 195 <211> LENGTH: 760 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sscIgG1-H7-2e12HL (w/2e12 linker
) (AA) <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(22) <223> OTHER INFORMATION:
Leader <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (23)..(128) <223> OTHER INFORMATION: VL
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (129)..(144) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (145)..(265) <223> OTHER INFORMATION: VH
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (268)..(282) <223> OTHER INFORMATION: Hinge
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (500)..(507) <223> OTHER INFORMATION: EFD-BD2
Linker <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (508)..(628) <223> OTHER INFORMATION:
VH2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (629)..(648) <223> OTHER INFORMATION:
Linker2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (649)..(760) <223> OTHER INFORMATION:
VL2 <400> SEQUENCE: 195 Met Asp Phe Gln Val Gln Ile Phe Ser
Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln
Ile Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro
Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val
Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro
Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70
75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
Gln Gln Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser
Gly Ala Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met
His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195
200 205 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
Tyr 210 215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
Tyr Phe Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr
Trp Tyr Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val
Ser Asp Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315
320 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
325 330 335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr 340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
Trp Leu Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440
445 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
450 455 460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met 465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser 485 490 495 Pro Gly Lys Gly Cys Pro Pro Cys Pro
Asn Ser Gln Val Gln Leu Lys 500 505 510 Glu Ser Gly Pro Gly Ser Val
Ala Pro Ser Gln Ser Leu Ser Ile Thr 515 520 525 Cys Thr Val Ser Gly
Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val 530 535 540 Arg Gln Pro
Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly 545 550 555 560
Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile 565
570 575 Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser
Leu 580 585 590 Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp
Gly Tyr Ser 595 600 605 Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly
Gln Gly Thr Ser Val 610 615 620 Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly 625 630 635 640 Gly Gly Ser Gly Gly Gly
Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 645 650 655 Ala Ser Leu Ala
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 660 665 670 Ala Ser
Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr 675 680 685
Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser 690
695 700 Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser
Gly 705 710 715 720 Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu
Asp Asp Ile Ala 725 730 735 Met Tyr Phe Cys Gln Gln Ser Arg Lys Val
Pro Trp Thr Phe Gly Gly 740 745 750 Gly Thr Lys Leu Glu Ile Lys Arg
755 760 <210> SEQ ID NO 196 <211> LENGTH: 2283
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H7-G194 HL (DNA) <400> SEQUENCE: 196 aagcttgccg
ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca 60
gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct
120 ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta
catgcactgg 180 taccagcaga agccaggatc ctcccccaaa ccctggattt
atgccccatc caacctggct 240 tctggagtcc ctgctcgctt cagtggcagt
gggtctggga cctcttactc tctcacaatc 300 agcagagtgg aggctgaaga
tgctgccact tattactgcc agcagtggag ttttaaccca 360 cccacgttcg
gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt 420
ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg
480 aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt
taccagttac 540 aatatgcact gggtaaagca gacacctaga cagggcctgg
aatggattgg agctatttat 600 ccaggaaatg gtgatacttc ctacaatcag
aagttcaagg gcaaggccac actgactgta 660 gacaaatcct ccagcacagc
ctacatgcag ctcagcagcc tgacatctga agactctgcg 720 gtctatttct
gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg 780
ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac
840 acatccccac cgtgcccagc acctgaactc ctggggggat cgtcagtctt
cctcttcccc 900 ccaaaaccca aggacaccct catgatctcc cggacccctg
aggtcacatg cgtggtggtg 960 gacgtgagcc acgaagaccc tgaggtcaag
ttcaactggt acgtggacgg cgtggaggtg 1020 cataatgcca agacaaagcc
gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 1080 gtcctcaccg
tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc 1140
aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga
1200 gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa
ccaggtcagc 1260 ctgacctgcc tggtcaaagg cttctatcca agcgacatcg
ccgtggagtg ggagagcaat 1320 gggcagccgg agaacaacta caagaccacg
cctcccgtgc tggactccga cggctccttc 1380 ttcctctaca gcaagctcac
cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1440 tgctccgtga
tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 1500
ccgggtaagg ggtgtccacc ttgtccgaat tctgaggtcc agctgcaaca gtctggacct
1560 gaactggtga agcctggagc ttcaatgaag atttcctgca aggcctctgg
ttactcattc 1620 actggctaca tcgtgaactg gctgaagcag agccatggaa
agaaccttga gtggattgga 1680 cttattaatc catacaaagg tcttactacc
tacaaccaga aattcaaggg caaggccaca 1740 ttaactgtag acaagtcatc
cagcacagcc tacatggagc tcctcagtct gacatctgaa 1800 gactctgcag
tctattactg tgcaagatct gggtactatg gtgactcgga ctggtacttc 1860
gatgtctggg gcgcagggac cacggtcacc gtctcctctg gtggcggtgg ctcgggcggt
1920 ggtggatctg gaggaggtgg gagcgctagc gacatccaga tgacacagac
tacatcctcc 1980 ctgtctgcct ctctgggaga cagagtcacc atcagttgca
gggcaagtca ggacattcgc 2040 aattatttaa actggtatca gcagaaacca
gatggaactg ttaaactcct gatctactac 2100 acatcaagat tacactcagg
agtcccatca aggttcagtg gcagtgggtc tggaacagat 2160 tattctctca
ccattgccaa cctgcaacca gaagatattg ccacttactt ttgccaacag 2220
ggtaatacgc ttccgtggac gttcggtgga ggcaccaaac tggtaaccaa acggtaatct
2280 aga 2283 <210> SEQ ID NO 197 <211> LENGTH: 754
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H7-G194 HL (w/2e12 leader) (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(22)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(128) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH1 <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(507) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (508)..(629) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (630)..(646) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (647)..(754) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 197 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Cys Pro Ala Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Gly Cys Pro Pro Cys Pro Asn Ser
Glu Val Gln Leu Gln 500 505 510 Gln Ser Gly Pro Glu Leu Val Lys Pro
Gly Ala Ser Met Lys Ile Ser 515 520 525 Cys Lys Ala Ser Gly Tyr Ser
Phe Thr Gly Tyr Ile Val Asn Trp Leu 530 535 540 Lys Gln Ser His Gly
Lys Asn Leu Glu Trp Ile Gly Leu Ile Asn Pro 545 550 555 560 Tyr Lys
Gly Leu Thr Thr Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 565 570 575
Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser 580
585 590 Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly
Tyr 595 600 605 Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala
Gly Thr Thr 610 615 620 Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 625 630 635 640 Gly Gly Gly Ser Ala Ser Asp Ile
Gln Met Thr Gln Thr Thr Ser Ser 645 650 655 Leu Ser Ala Ser Leu Gly
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 660 665 670 Gln Asp Ile Arg
Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 675 680 685 Thr Val
Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val 690 695 700
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 705
710 715 720 Ile Ala Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys
Gln Gln 725 730 735 Gly Asn Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Val Thr 740 745 750 Lys Arg <210> SEQ ID NO 198
<211> LENGTH: 2298 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-H7-G281 HL (DNA) <400>
SEQUENCE: 198 aagcttgccg ccatggattt tcaagtgcag attttcagct
tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc
tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat
gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga
agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct 240
tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc
300 agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag
ttttaaccca 360 cccacgttcg gtgctgggac caagctggag ctgaaagatg
gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct
tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa
gatgtcctgc aaggcttctg gctacacatt taccagttac 540 aatatgcact
gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat 600
ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta
660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga
agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat agtaactctt
actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat
caggagccca aatcttctga caaaactcac 840 acatccccac cgtgcccagc
acctgaactc ctggggggat cgtcagtctt cctcttcccc 900 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 960
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa
accatctcca aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc
tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat 1320
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc
1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa
cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc
agaagagcct ctccctgtct 1500 ccgggtaagg ggtgtccacc ttgtccgaat
tctgaggtcc agctgcaaca gtctggacct 1560 gaactggtga agcctggagc
ttcaatgaag atttcctgca aggcctctgg ttactcattc 1620 actggctaca
tcgtgaactg gctgaagcag agccatggaa agaaccttga gtggattgga 1680
cttattaatc catacaaagg tcttactacc tacaaccaga aattcaaggg caaggccaca
1740 ttaactgtag acaagtcatc cagcacagcc tacatggagc tcctcagtct
gacatctgaa 1800 gactctgcag tctattactg tgcaagatct gggtactatg
gtgactcgga ctggtacttc 1860 gatgtctggg gcgcagggac cacggtcacc
gtctcctctg gtggcggtgg ctcgggcggt 1920 ggtggatctg gaggaggtgg
gagcggggga ggtggcagtg ctagcgacat ccagatgaca 1980 cagactacat
cctccctgtc tgcctctctg ggagacagag tcaccatcag ttgcagggca 2040
agtcaggaca ttcgcaatta tttaaactgg tatcagcaga aaccagatgg aactgttaaa
2100 ctcctgatct actacacatc aagattacac tcaggagtcc catcaaggtt
cagtggcagt 2160 gggtctggaa cagattattc tctcaccatt gccaacctgc
aaccagaaga tattgccact 2220 tacttttgcc aacagggtaa tacgcttccg
tggacgttcg gtggaggcac caaactggta 2280 accaaacggt aatctaga 2298
<210> SEQ ID NO 199 <211> LENGTH: 759 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sssIgG1-H7-G281 HL (w/2e12
leader) (AA) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(22) <223> OTHER
INFORMATION: Leader <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (23)..(128) <223> OTHER
INFORMATION: VL1 <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (129)..(144) <223> OTHER
INFORMATION: Linker <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (145)..(265) <223> OTHER
INFORMATION: VH1 <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (268)..(282) <223> OTHER
INFORMATION: Hinge <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (500)..(507) <223> OTHER
INFORMATION: EFD-BD2 Linker <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (508)..(629)
<223> OTHER INFORMATION: VH2 <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (630)..(651)
<223> OTHER INFORMATION: Linker2 <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(652)..(759) <223> OTHER INFORMATION: VL2 <400>
SEQUENCE: 199 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile
Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser
Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly Glu Lys Val
Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser Tyr Met His
Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys Pro Trp Ile
Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80 Ala Arg Phe
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85 90 95 Ser
Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 100 105
110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val
Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp Val Lys Gln
Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala Ile Tyr Pro
Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205 Lys Gly Lys
Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210 215 220 Met
Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 225 230
235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val
Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro
Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330 335 His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 340 345 350
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 355
360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455 460 Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 465 470 475
480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
485 490 495 Pro Gly Lys Gly Cys Pro Pro Cys Pro Asn Ser Glu Val Gln
Leu Gln 500 505 510 Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser
Met Lys Ile Ser 515 520 525 Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly
Tyr Ile Val Asn Trp Leu 530 535 540 Lys Gln Ser His Gly Lys Asn Leu
Glu Trp Ile Gly Leu Ile Asn Pro 545 550 555 560 Tyr Lys Gly Leu Thr
Thr Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 565 570 575 Leu Thr Val
Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser 580 585 590 Leu
Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 595 600
605 Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr
610 615 620 Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly 625 630 635 640 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser
Asp Ile Gln Met Thr 645 650 655 Gln Thr Thr Ser Ser Leu Ser Ala Ser
Leu Gly Asp Arg Val Thr Ile 660 665 670 Ser Cys Arg Ala Ser Gln Asp
Ile Arg Asn Tyr Leu Asn Trp Tyr Gln 675 680 685 Gln Lys Pro Asp Gly
Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 690 695 700 Leu His Ser
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 705 710 715 720
Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro Glu Asp Ile Ala Thr 725
730 735 Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gly
Gly 740 745 750 Thr Lys Leu Val Thr Lys Arg 755 <210> SEQ ID
NO 200 <211> LENGTH: 1533 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2e12-sss-IgG1 HL SMIP (DNA) <400>
SEQUENCE: 200 atggattttc aagtgcagat tttcagcttc ctgctaatca
gtgcttcagt cataatgtcc 60 agaggagtcc aggtgcagct gaaggagtca
ggacctggcc tggtggcgcc ctcacagagc 120 ctgtccatca catgcaccgt
ctcagggttc tcattaaccg gctatggtgt aaactgggtt 180 cgccagcctc
caggaaaggg tctagagtgg ctgggaatga tatggggtga tggaagcaca 240
gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc caagagccaa
300 gttttcttaa aaatgaacag tctgcaaact gatgacacag ccagatacta
ctgtgctcga 360 gatggttata gtaactttca ttactatgtt atggactact
ggggtcaagg aacctcagtc 420 accgtctcct ctgggggtgg aggctctggt
ggcggtggat ccggcggagg tgggtcgggt 480 ggcggcggat ctgacattgt
gctcacccaa tctccagctt ctttggctgt gtctctaggt 540 cagagagcca
ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta 600
atgcagtggt accaacagaa accaggacag ccacccaaac tcctcatctc tgctgctagc
660 aacgtagaat ctggggtccc tgccaggttt agtggcagtg ggtctgggac
agactttagc 720 ctcaacatcc atcctgtgga ggaggatgat attgcaatgt
atttctgtca gcaaagtagg 780 aaggttccat ggacgttcgg tggaggcacc
aagctggaaa tcaaacgtga tcaggagccc 840 aaatcttctg acaaaactca
cacatcccca ccgtccccag cacctgaact cctgggggga 900 tcgtcagtct
tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 960
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg
1020 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga
gcagtacaac 1080 agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc
aggactggct gaatggcaag 1140 gagtacaagt gcaaggtctc caacaaagcc
ctcccagcct ccatcgagaa aacaatctcc 1200 aaagccaaag ggcagccccg
agaaccacag gtgtacaccc tgcccccatc ccgggatgag 1260 ctgaccaaga
accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 1320
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg
1380 ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa
gagcaggtgg 1440 cagcagggga acgtcttctc atgctccgtg atgcatgagg
ctctgcacaa ccactacacg 1500 cagaagagcc tctccctgtc tccgggtaaa tga
1533 <210> SEQ ID NO 201 <211> LENGTH: 510 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: 2e12-sss-IgG1 HL SMIP (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(22) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (24)..(144) <223> OTHER INFORMATION: VH <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(164) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(165)..(276) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(279)..(293) <223> OTHER INFORMATION: Hinge <400>
SEQUENCE: 201 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile
Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Val Gln Val Gln Leu
Lys Glu Ser Gly Pro 20 25 30 Gly Leu Val Ala Pro Ser Gln Ser Leu
Ser Ile Thr Cys Thr Val Ser 35 40 45 Gly Phe Ser Leu Thr Gly Tyr
Gly Val Asn Trp Val Arg Gln Pro Pro 50 55 60 Gly Lys Gly Leu Glu
Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 65 70 75 80 Asp Tyr Asn
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 85 90 95 Ser
Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 100 105
110 Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr
115 120 125 Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val
Ser Ser 130 135 140 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly 145 150 155 160 Gly Gly Gly Ser Asp Ile Val Leu Thr
Gln Ser Pro Ala Ser Leu Ala 165 170 175 Val Ser Leu Gly Gln Arg Ala
Thr Ile Ser Cys Arg Ala Ser Glu Ser 180 185 190 Val Glu Tyr Tyr Val
Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 195 200 205 Gly Gln Pro
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 210 215 220 Gly
Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 225 230
235 240 Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe
Cys 245 250 255 Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly
Thr Lys Leu 260 265 270 Glu Ile Lys Arg Asp Gln Glu Pro Lys Ser Ser
Asp Lys Thr His Thr 275 280 285 Ser Pro Pro Ser Pro Ala Pro Glu Leu
Leu Gly Gly Ser Ser Val Phe 290 295 300 Leu Phe Pro Pro Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro 305 310 315 320 Glu Val Thr Cys
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 325 330 335 Lys Phe
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 340 345 350
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 355
360 365 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
Cys 370 375 380 Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys
Thr Ile Ser 385 390 395 400 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro 405 410 415 Ser Arg Asp Glu Leu Thr Lys Asn
Gln Val Ser Leu Thr Cys Leu Val 420 425 430 Lys Gly Phe Tyr Pro Ser
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 435 440 445 Gln Pro Glu Asn
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 450 455 460 Gly Ser
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 465 470 475
480 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
485 490 495 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
500 505 510 <210> SEQ ID NO 202 <211> LENGTH: 1518
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: 2e12-sss-IgG1
LH SMIP (DNA) <400> SEQUENCE: 202 atggattttc aagtgcagat
tttcagcttc ctgctaatca gtgcttcagt cataatgtcc 60 agaggagtcg
acattgtgct cacccaatct ccagcttctt tggctgtgtc tctaggtcag 120
agagccacca tctcctgcag agccagtgaa agtgttgaat attatgtcac aagtttaatg
180 cagtggtacc aacagaaacc aggacagcca cccaaactcc tcatctctgc
tgctagcaac 240 gtagaatctg gggtccctgc caggtttagt ggcagtgggt
ctgggacaga ctttagcctc 300 aacatccatc ctgtggagga ggatgatatt
gcaatgtatt tctgtcagca aagtaggaag 360 gttccatgga cgttcggtgg
aggcaccaag ctggaaatca aacggggtgg cggtggatcc 420 ggcggaggtg
ggtcgggtgg cggcggatct caggtgcagc tgaaggagtc aggacctggc 480
ctggtggcgc cctcacagag cctgtccatc acatgcaccg tctcagggtt ctcattaacc
540 ggctatggtg taaactgggt tcgccagcct ccaggaaagg gtctagagtg
gctgggaatg 600 atatggggtg atggaagcac agactataat tcagctctca
aatccagact atcgatcacc 660 aaggacaact ccaagagcca agttttctta
aaaatgaaca gtctgcaaac tgatgacaca 720 gccagatact actgtgctcg
agatggttat agtaactttc attactatgt tatggactac 780 tggggtcaag
gaacctcagt caccgtctcc tctgatcagg agcccaaatc ttctgacaaa 840
actcacacat ccccaccgtc cccagcacct gaactcctgg ggggaccgtc agtcttcctc
900 ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt
cacatgcgtg 960 gtggtggacg tgagccacga agaccctgag gtcaagttca
actggtacgt ggacggcgtg 1020 gaggtgcata atgccaagac aaagccgcgg
gaggagcagt acaacagcac gtaccgtgtg 1080 gtcagcgtcc tcaccgtcct
gcaccaggac tggctgaatg gcaaggagta caagtgcaag 1140 gtctccaaca
aagccctccc agcccccatc gagaaaacaa tctccaaagc caaagggcag 1200
ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag
1260 gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt
ggagtgggag 1320 agcaatgggc agccggagaa caactacaag accacgcctc
ccgtgctgga ctccgacggc 1380 tccttcttcc tctacagcaa gctcaccgtg
gacaagagca ggtggcagca ggggaacgtc 1440 ttctcatgct ccgtgatgca
tgaggctctg cacaaccact acacgcagaa gagcctctcc 1500 ctgtctccgg
gtaaatga 1518 <210> SEQ ID NO 203 <211> LENGTH: 505
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: 2e12-sss-IgG1
LH SMIP (AA) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(23) <223> OTHER
INFORMATION: Leader <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (24)..(135) <223> OTHER
INFORMATION: VL <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (136)..(150) <223> OTHER
INFORMATION: Linker <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (151)..(271) <223> OTHER
INFORMATION: VH <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (274)..(288) <223> OTHER
INFORMATION: Hinge <400> SEQUENCE: 203 Met Asp Phe Gln Val
Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met
Ser Arg Gly Val Asp Ile Val Leu Thr Gln Ser Pro Ala 20 25 30 Ser
Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 35 40
45 Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln
50 55 60 Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala
Ser Asn 65 70 75 80 Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
Gly Ser Gly Thr 85 90 95 Asp Phe Ser Leu Asn Ile His Pro Val Glu
Glu Asp Asp Ile Ala Met 100 105 110 Tyr Phe Cys Gln Gln Ser Arg Lys
Val Pro Trp Thr Phe Gly Gly Gly 115 120 125 Thr Lys Leu Glu Ile Lys
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly 130 135 140 Ser Gly Gly Gly
Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 145 150 155 160 Leu
Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 165 170
175 Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly
180 185 190 Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser
Thr Asp 195 200 205 Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr
Lys Asp Asn Ser 210 215 220 Lys Ser Gln Val Phe Leu Lys Met Asn Ser
Leu Gln Thr Asp Asp Thr 225 230 235 240 Ala Arg Tyr Tyr Cys Ala Arg
Asp Gly Tyr Ser Asn Phe His Tyr Tyr 245 250 255 Val Met Asp Tyr Trp
Gly Gln Gly Thr Ser Val Thr Val Ser Ser Asp 260 265 270 Gln Glu Pro
Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 275 280 285 Ala
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 290 295
300 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
305 310 315 320 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr 325 330 335 Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg Glu Glu 340 345 350 Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val Leu His 355 360 365 Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys 370 375 380 Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 385 390 395 400 Pro Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 405 410 415
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 420
425 430 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
Asn 435 440 445 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu 450 455 460 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val 465 470 475 480 Phe Ser Cys Ser Val Met His Glu
Ala Leu His Asn His Tyr Thr Gln 485 490 495 Lys Ser Leu Ser Leu Ser
Pro Gly Lys 500 505 <210> SEQ ID NO 204 <211> LENGTH:
1498 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: G28-1
LH SMIP (DNA) <400> SEQUENCE: 204 aagcttgccg ccatggaagc
accagcgcag cttctcttcc tcctgctact ctggctccca 60 gataccaccg
gtgacatcca gatgactcag tctccagcct ccctatctgc atctgtggga 120
gagactgtca ccatcacatg tcgaacaagt gaaaatgttt acagttattt ggcttggtat
180 cagcagaaac agggaaaatc tcctcagctc ctggtctctt ttgcaaaaac
cttagcagaa 240 ggtgtgccat caaggttcag tggcagtgga tcaggcacac
agttttctct gaagatcagc 300 agcctgcagc ctgaagattc tggaagttat
ttctgtcaac atcattccga taatccgtgg 360 acgttcggtg gaggcaccga
actggagatc aaaggtggcg gtggctcggg cggtggtggg 420 tcgggtggcg
gcggatctgc tagcgcagtc cagctgcagc agtctggacc tgagctggaa 480
aagcctggcg cttcagtgaa gatttcctgc aaggcttctg gttactcatt cactggctac
540 aatatgaact gggtgaagca gaataatgga aagagccttg agtggattgg
aaatattgat 600 ccttattatg gtggtactac ctacaaccgg aagttcaagg
gcaaggccac attgactgta 660 gacaaatcct ccagcacagc ctacatgcag
ctcaagagtc tgacatctga ggactctgca 720 gtctattact gtgcaagatc
ggtcggccct atggactact ggggtcaagg aacctcagtc 780 accgtctcga
gcgagcccaa atcttctgac aaaactcaca catgcccacc gtgcccagca 840
cctgaactcc tgggtggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc
900 atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca
cgaagaccct 960 gaggtcaagt tcaactggta cgtggacggc gtggaggtgc
ataatgccaa gacaaagccg 1020 cgggaggagc agtacaacag cacgtaccgt
gtggtcagcg tcctcaccgt cctgcaccag 1080 gactggctga atggcaagga
gtacaagtgc aaggtctcca acaaagccct cccagccccc 1140 atcgagaaaa
ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg 1200
cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc
1260 ttctatccaa gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga
gaacaactac 1320 aagaccacgc ctcccgtgct ggactccgac ggctccttct
tcctctacag caagctcacc 1380 gtggacaaga gcaggtggca gcaggggaac
gtcttctcat gctccgtgat gcatgaggct 1440 ctgcacaacc actacacgca
gaagagcctc tccctgtctc cgggtaagtg actctaga 1498 <210> SEQ ID
NO 205 <211> LENGTH: 492 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: G28-1 LH SMIP (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(21)..(127) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(128)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(260) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(261)..(275) <223> OTHER INFORMATION: Hinge <400>
SEQUENCE: 205 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser
Pro Ala Ser Leu Ser 20 25 30 Ala Ser Val Gly Glu Thr Val Thr Ile
Thr Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr Ser Tyr Leu Ala Trp
Tyr Gln Gln Lys Gln Gly Lys Ser Pro 50 55 60 Gln Leu Leu Val Ser
Phe Ala Lys Thr Leu Ala Glu Gly Val Pro Ser 65 70 75 80 Arg Phe Ser
Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Ser 85 90 95 Ser
Leu Gln Pro Glu Asp Ser Gly Ser Tyr Phe Cys Gln His His Ser 100 105
110 Asp Asn Pro Trp Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys Gly
115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Ser 130 135 140 Ala Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu
Lys Pro Gly Ala 145 150 155 160 Ser Val Lys Ile Ser Cys Lys Ala Ser
Gly Tyr Ser Phe Thr Gly Tyr 165 170 175 Asn Met Asn Trp Val Lys Gln
Asn Asn Gly Lys Ser Leu Glu Trp Ile 180 185 190 Gly Asn Ile Asp Pro
Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 195 200 205 Lys Gly Lys
Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210 215 220 Met
Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 225 230
235 240 Ala Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser
Val 245 250 255 Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His
Thr Cys Pro 260 265 270 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr Cys Val Val Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe 305 310 315 320 Asn Trp Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 325 330 335 Arg Glu
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 340 345 350
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 355
360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430 Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435 440 445 Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 450 455 460 Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 465 470 475
480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485 490
<210> SEQ ID NO 206 <211> LENGTH: 1522 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: G28-1 HL SMIP (DNA)
<400> SEQUENCE: 206 aagcttgccg ccatggaagc accagcgcag
cttctcttcc tcctgctact ctggctccca 60 gataccaccg gtgcggtcca
gctgcagcag tctggacctg agtcggaaaa gcctggcgct 120 tcagtgaaga
tttcctgcaa ggcttctggt tactcattca ctggctacaa tatgaactgg 180
gtgaagcaga ataatggaaa gagccttgag tggattggaa atattgatcc ttattatggt
240 ggtactacct acaaccggaa gttcaagggc aaggccacat tgactgtaga
caaatcctcc 300 ggcacagcct acatgcagct caagagtctg acatctgagg
actctgcagt ctattactgt 360 gcaagatcgg tcggccctat ggactactgg
ggtcaaggaa cctcagtcac cgtctcttct 420 ggtggcggtg gctcgggcgg
tggtgggtcg ggtggcggcg gatcaggagg aggcgggagt 480 gctagcgaca
tccagatgac tcagtctcca gcctccctat ctgcatctgt gggagagact 540
gtcaccatca catgtcgaac aagtgaaaat gtttacagtt atttggcttg gtatcagcag
600 aaacagggaa aatctcctca gctcctggtc tcttttgcaa aaaccttagc
agaaggtgtg 660 ccatcaaggt tcagtggcag tggatcaggc acacagtttt
ctctgaagat cagcagcctg 720 cagcctgaag attctggaag ttatttctgt
caacatcatt ccgataatcc gtggacgttc 780 ggtggaggca ccgaactgga
gatcaaaggc tcgagcgagc ccaaatcttc tgacaaaact 840 cacacatgcc
caccgtgccc agcacctgaa ctcctgggtg gaccgtcagt cttcctcttc 900
cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg
960 gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga
cggcgtggag 1020 gtgcataatg ccaagacaaa gccgcgggag gagcagtaca
acagcacgta ccgtgtggtc 1080 agcgtcctca ccgtcctgca ccaggactgg
ctgaatggca aggagtacaa gtgcaaggtc 1140 tccaacaaag ccctcccagc
ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1200 cgagaaccac
aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc 1260
agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc
1320 aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc
cgacggctcc 1380 ttcttcctct acagcaagct caccgtggac aagagcaggt
ggcagcaggg gaacgtcttc 1440 tcatgctccg tgatgcatga ggctctgcac
aaccactaca cgcagaagag cctctccctg 1500 tctccgggta agtgactcta ga 1522
<210> SEQ ID NO 207 <211> LENGTH: 500 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: G28-1 HL SMIP (AA) <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1)..(20) <223> OTHER INFORMATION: Leader <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(21)..(136) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(137)..(158) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(159)..(266) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(283) <223> OTHER INFORMATION: Hinge <400>
SEQUENCE: 207 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Ala Val Gln Leu Gln Gln Ser
Gly Pro Glu Ser Glu 20 25 30 Lys Pro Gly Ala Ser Val Lys Ile Ser
Cys Lys Ala Ser Gly Tyr Ser 35 40 45 Phe Thr Gly Tyr Asn Met Asn
Trp Val Lys Gln Asn Asn Gly Lys Ser 50 55 60 Leu Glu Trp Ile Gly
Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr 65 70 75 80 Asn Arg Lys
Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 85 90 95 Gly
Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala 100 105
110 Val Tyr Tyr Cys Ala Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln
115 120 125 Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly 130 135 140 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Ser Asp Ile 145 150 155 160 Gln Met Thr Gln Ser Pro Ala Ser Leu
Ser Ala Ser Val Gly Glu Thr 165 170 175 Val Thr Ile Thr Cys Arg Thr
Ser Glu Asn Val Tyr Ser Tyr Leu Ala 180 185 190 Trp Tyr Gln Gln Lys
Gln Gly Lys Ser Pro Gln Leu Leu Val Ser Phe 195 200 205 Ala Lys Thr
Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 210 215 220 Ser
Gly Thr Gln Phe Ser Leu Lys Ile Ser Ser Leu Gln Pro Glu Asp 225 230
235 240 Ser Gly Ser Tyr Phe Cys Gln His His Ser Asp Asn Pro Trp Thr
Phe 245 250 255 Gly Gly Gly Thr Glu Leu Glu Ile Lys Gly Ser Ser Glu
Pro Lys Ser 260 265 270 Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
Ala Pro Glu Leu Leu 275 280 285 Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro Lys Asp Thr Leu 290 295 300 Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val Asp Val Ser 305 310 315 320 His Glu Asp Pro
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 325 330 335 Val His
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 340 345 350
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 355
360 365 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
Pro 370 375 380 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
Glu Pro Gln 385 390 395 400 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
Leu Thr Lys Asn Gln Val 405 410 415 Ser Leu Thr Cys Leu Val Lys Gly
Phe Tyr Pro Ser Asp Ile Ala Val 420 425 430 Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 435 440 445 Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 450 455 460 Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 465 470 475
480 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
485 490 495 Ser Pro Gly Lys 500 <210> SEQ ID NO 208
<211> LENGTH: 1522 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: G19-4 LH SMIP (DNA) <400> SEQUENCE: 208
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca
60 gataccaccg gtgacatcca gatgacacag actacatcct ccctgtctgc
ctctctggga 120 gacagagtca ccatcagttg cagggcaagt caggacattc
gcaattattt aaactggtat 180 cagcagaaac cagatggaac tgttaaactc
ctgatctact acacatcaag attacactca 240 ggagtcccat caaggttcag
tggcagtggg tctggaacag attattctct caccattgcc 300 aacctgcaac
cagaagatat tgccacttac ttttgccaac agggtaatac gcttccgtgg 360
acgttcggtg gaggcaccaa actggtaacc aaacggggtg gcggtggctc gggcggtggt
420 ggatctggag gaggtgggag cgctagcgag gtccagctgc aacagtctgg
acctgaactg 480 gtgaagcctg gagcttcaat gaagatttcc tgcaaggcct
ctggttactc attcactggc 540 tacatcgtga actggctgaa gcagagccat
ggaaagaacc ttgagtggat tggacttatt 600 aatccataca aaggtcttac
tacctacaac cagaaattca agggcaaggc cacattaact 660 gtagacaagt
catccagcac agcctacatg gagctcctca gtctgacatc tgaagactct 720
gcagtctatt actgtgcaag atctgggtac tatggtgact cggactggta cttcgatgtc
780 tggggcgcag ggaccacggt caccgtctcc tcgagcgagc ccaaatcttc
tgacaaaact 840 cacacatgcc caccgtgccc agcacctgaa ctcctgggtg
gaccgtcagt cttcctcttc 900 cccccaaaac ccaaggacac cctcatgatc
tcccggaccc ctgaggtcac atgcgtggtg 960 gtggacgtga gccacgaaga
ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1020 gtgcataatg
ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1080
agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc
1140 tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa
agggcagccc 1200 cgagaaccac aggtgtacac cctgccccca tcccgggatg
agctgaccaa gaaccaggtc 1260 agcctgacct gcctggtcaa aggcttctat
ccaagcgaca tcgccgtgga gtgggagagc 1320 aatgggcagc cggagaacaa
ctacaagacc acgcctcccg tgctggactc cgacggctcc 1380 ttcttcctct
acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 1440
tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg
1500 tctccgggta agtgactcta ga 1522 <210> SEQ ID NO 209
<211> LENGTH: 500 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: G19-4 LH SMIP (AA) <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Leader <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (21)..(128)
<223> OTHER INFORMATION: VL <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (129)..(145)
<223> OTHER INFORMATION: Linker <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(146)..(267) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <400>
SEQUENCE: 209 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Thr
Thr Ser Ser Leu Ser 20 25 30 Ala Ser Leu Gly Asp Arg Val Thr Ile
Ser Cys Arg Ala Ser Gln Asp 35 40 45 Ile Arg Asn Tyr Leu Asn Trp
Tyr Gln Gln Lys Pro Asp Gly Thr Val 50 55 60 Lys Leu Leu Ile Tyr
Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 65 70 75 80 Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ala 85 90 95 Asn
Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 100 105
110 Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Val Thr Lys Arg
115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ala 130 135 140 Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu
Val Lys Pro Gly 145 150 155 160 Ala Ser Met Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ser Phe Thr Gly 165 170 175 Tyr Ile Val Asn Trp Leu Lys
Gln Ser His Gly Lys Asn Leu Glu Trp 180 185 190 Ile Gly Leu Ile Asn
Pro Tyr Lys Gly Leu Thr Thr Tyr Asn Gln Lys 195 200 205 Phe Lys Gly
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 210 215 220 Tyr
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 225 230
235 240 Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp
Val 245 250 255 Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ser Glu
Pro Lys Ser 260 265 270 Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
Ala Pro Glu Leu Leu 275 280 285 Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro Lys Asp Thr Leu 290 295 300 Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val Asp Val Ser 305 310 315 320 His Glu Asp Pro
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 325 330 335 Val His
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 340 345 350
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 355
360 365 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
Pro 370 375 380 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
Glu Pro Gln 385 390 395 400 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
Leu Thr Lys Asn Gln Val 405 410 415 Ser Leu Thr Cys Leu Val Lys Gly
Phe Tyr Pro Ser Asp Ile Ala Val 420 425 430 Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 435 440 445 Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 450 455 460 Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 465 470 475
480 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
485 490 495 Ser Pro Gly Lys 500 <210> SEQ ID NO 210
<211> LENGTH: 1525 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: G19-4 HL SMIP (DNA) <400> SEQUENCE: 210
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca
60 gataccaccg gtgaggtcca gctgcaacag tctggacctg aactggtgaa
gcctggagct 120 tcaatgaaga tttcctgcaa ggcctctggt tactcattca
ctggctacat cgtgaactgg 180 ctgaagcaga gccatggaaa gaaccttgag
tggattggac ttattaatcc atacaaaggt 240 cttactacct acaaccagaa
attcaagggc aaggccacat tgactgtaga caagtcatcc 300 agcacagcct
acatggagct cctcagtctg acatctgaag actctgcagt ctattactgt 360
gcaagatctg ggtactatgg tgactcagac tggtacttcg atgtctgggg cgcagggacc
420 acagtcaccg tctcctctgg cggcggtggc tcgggcggtg gtggatctgg
aggaggtggg 480 agcgctagcg acatccagat gacacagact acatcctccc
tgtctgcctc tctgggagac 540 agagtcacca tcagttgcag ggcaagtcag
gacattcgca attatttgaa ctggtatcag 600 cagaaaccag atggaactgt
taaactcctg atctactaca catcaagact acactcagga 660 gtcccatcaa
ggttcagtgg cagtgggtct ggaacagatt attctctcac cattgccaac 720
ctgcaaccag aagatattgc cacttacttt tgccaacagg gtaatacact tccctggacg
780 ttcggtggag ggaccaaact ggtgaccaaa cgctcgagcg agcccaaatc
ttctgacaaa 840 actcacacat gcccaccgtg cccagcacct gaactcctgg
gtggaccgtc agtcttcctc 900 ttccccccaa aacccaagga caccctcatg
atctcccgga cccctgaggt cacatgcgtg 960 gtggtggacg tgagccacga
agaccctgag gtcaagttca actggtacgt ggacggcgtg 1020 gaggtgcata
atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg 1080
gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag
1140 gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc
caaagggcag 1200 ccccgagaac cacaggtgta caccctgccc ccatcccggg
atgagctgac caagaaccag 1260 gtcagcctga cctgcctggt caaaggcttc
tatccaagcg acatcgccgt ggagtgggag 1320 agcaatgggc agccggagaa
caactacaag accacgcctc ccgtgctgga ctccgacggc 1380 tccttcttcc
tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 1440
ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc
1500 ctgtctccgg gtaagtgact ctaga 1525 <210> SEQ ID NO 211
<211> LENGTH: 501 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: G19-4 HL SMIP (AA) <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Leader <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (21)..(142)
<223> OTHER INFORMATION: VH <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (143)..(159)
<223> OTHER INFORMATION: Linker <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(160)..(267) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(270)..(284) <223> OTHER INFORMATION: Hinge <400>
SEQUENCE: 211 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Val Gln Leu Gln Gln Ser
Gly Pro Glu Leu Val 20 25 30 Lys Pro Gly Ala Ser Met Lys Ile Ser
Cys Lys Ala Ser Gly Tyr Ser 35 40 45 Phe Thr Gly Tyr Ile Val Asn
Trp Leu Lys Gln Ser His Gly Lys Asn 50 55 60 Leu Glu Trp Ile Gly
Leu Ile Asn Pro Tyr Lys Gly Leu Thr Thr Tyr 65 70 75 80 Asn Gln Lys
Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 85 90 95 Ser
Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala 100 105
110 Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr
115 120 125 Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
Gly Gly 130 135 140 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ala Ser Asp 145 150 155 160 Ile Gln Met Thr Gln Thr Thr Ser Ser
Leu Ser Ala Ser Leu Gly Asp 165 170 175 Arg Val Thr Ile Ser Cys Arg
Ala Ser Gln Asp Ile Arg Asn Tyr Leu 180 185 190 Asn Trp Tyr Gln Gln
Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 195 200 205 Tyr Thr Ser
Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 210 215 220 Gly
Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro Glu 225 230
235 240 Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp
Thr 245 250 255 Phe Gly Gly Gly Thr Lys Leu Val Thr Lys Arg Ser Ser
Glu Pro Lys 260 265 270 Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
Pro Ala Pro Glu Leu 275 280 285 Leu Gly Gly Pro Ser Val Phe Leu Phe
Pro Pro Lys Pro Lys Asp Thr 290 295 300 Leu Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val Val Asp Val 305 310 315 320 Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 325 330 335 Glu Val
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 340 345 350
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 355
360 365 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
Ala 370 375 380 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
Arg Glu Pro 385 390 395 400 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
Glu Leu Thr Lys Asn Gln 405 410 415 Val Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala 420 425 430 Val Glu Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 435 440 445 Pro Pro Val Leu
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 450 455 460 Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 465 470 475
480 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
485 490 495 Leu Ser Pro Gly Lys 500 <210> SEQ ID NO 212
<211> LENGTH: 2328 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: n2H7sssIgG1-STD1-2e12HL (DNA) <400>
SEQUENCE: 212 aagcttgccg ccatggaagc accagcgcag cttctcttcc
tcctgctact ctggctccca 60 gataccaccg gtcaaattgt tctctcccag
tctccagcaa tcctgtctgc atctccaggg 120 gagaaggtca caatgacttg
cagggccagc tcaagtgtaa gttacatgca ctggtaccag 180 cagaagccag
gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga 240
gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcaga
300 gtggaggctg aagatgctgc cacttattac tgccagcagt ggagttttaa
cccacccacg 360 ttcggtgctg ggaccaagct ggagctgaaa gatggcggtg
gctcgggcgg tggtggatct 420 ggaggaggtg gagctagcca ggcttatcta
cagcagtctg gggctgagct ggtgaggcct 480 ggggcctcag tgaagatgtc
ctgcaaggct tctggctaca catttaccag ttacaatatg 540 cactgggtaa
agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga 600
aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac tgtagacaaa
660 tcctccagca cagcctacat gcagctcagc agcctgacat ctgaagactc
tgcggtctat 720 ttctgtgcaa gagtggtgta ctatagtaac tcttactggt
acttcgatgt ctggggcaca 780 gggaccacgg tcaccgtctc gagcgagccc
aaatcttctg acaaaactca cacatcccca 840 ccgagcccag cacctgaact
cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 900 aaggacaccc
tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 960
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc
1020 aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag
cgtcctcacc 1080 gtcctgcacc aggactggct gaatggcaag gagtacaagt
gcaaggtctc caacaaagcc 1140 ctcccagccc ccatcgagaa aacaatctcc
aaagccaaag ggcagccccg agaaccacag 1200 gtgtacaccc tgcccccatc
ccgggatgag ctgaccaaga accaggtcag cctgacctgc 1260 ctggtcaaag
gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 1320
gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac
1380 agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc
atgctccgtg 1440 atgcatgagg ctctgcacaa ccactacacg cagaagagcc
tctccctgtc tccgggtaag 1500 aattatggtg gcggtggctc gggcggtggt
ggatctggag gaggtgggag tgggaattct 1560 caggtgcagc tgaaggagtc
aggacctggc ctggtggcgc cctcacagag cctgtccatc 1620 acatgcaccg
tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct 1680
ccaggaaagg gtctggagtg gctgggaatg atatggggtg atggaagcac agactataat
1740 tcagctctca aatccagact atcgatcacc aaggacaact ccaagagcca
agttttctta 1800 aaaatgaaca gtctgcaaac tgatgacaca gccagatact
actgtgctcg agatggttat 1860 agtaactttc attactatgt tatggactac
tggggtcaag gaacctcagt caccgtctcc 1920 tctgggggtg gaggctctgg
tggcggtgga tccggcggag gtgggtcggg tggcggcgga 1980 tctgacattg
tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc 2040
accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg
2100 taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag
caacgtagaa 2160 tctggggtcc ctgccaggtt tagtggcagt gggtctggga
cagactttag cctcaacatc 2220 catcctgtgg aggaggatga tattgcaatg
tatttctgtc agcaaagtag gaaggttcca 2280 tggacgttcg gtggaggcac
caagctggaa atcaaacgtt aatctaga 2328 <210> SEQ ID NO 213
<211> LENGTH: 769 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: n2H7sssIgG1-STD1-2e12HL (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(21)..(127) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(128)..(142) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(516) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (517)..(637) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (638)..(657) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (658)..(769) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 213 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190 Ile Tyr
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 210
215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala
Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp
Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330
335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455
460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 495 Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly 500 505 510 Ser Gly Asn Ser Gln Val Gln Leu Lys
Glu Ser Gly Pro Gly Leu Val 515 520 525 Ala Pro Ser Gln Ser Leu Ser
Ile Thr Cys Thr Val Ser Gly Phe Ser 530 535 540 Leu Thr Gly Tyr Gly
Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly 545 550 555 560 Leu Glu
Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn 565 570 575
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser 580
585 590 Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala
Arg 595 600 605 Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr
Tyr Val Met 610 615 620 Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val
Ser Ser Gly Gly Gly 625 630 635 640 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly 645 650 655 Ser Asp Ile Val Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu 660 665 670 Gly Gln Arg Ala
Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr 675 680 685 Tyr Val
Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro 690 695 700
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro 705
710 715 720 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu
Asn Ile 725 730 735 His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe
Cys Gln Gln Ser 740 745 750 Arg Lys Val Pro Trp Thr Phe Gly Gly Gly
Thr Lys Leu Glu Ile Lys 755 760 765 Arg <210> SEQ ID NO 214
<211> LENGTH: 2313 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: n2H7sssIgG1-STD2-2e12LH (DNA) <400>
SEQUENCE: 214 aagcttgccg ccatggaagc accagcgcag cttctcttcc
tcctgctact ctggctccca 60 gataccaccg gtcaaattgt tctctcccag
tctccagcaa tcctgtctgc atctccaggg 120 gagaaggtca caatgacttg
cagggccagc tcaagtgtaa gttacatgca ctggtaccag 180 cagaagccag
gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga 240
gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcaga
300 gtggaggctg aagatgctgc cacttattac tgccagcagt ggagttttaa
cccacccacg 360 ttcggtgctg ggaccaagct ggagctgaaa gatggcggtg
gctcgggcgg tggtggatct 420 ggaggaggtg gagctagcca ggcttatcta
cagcagtctg gggctgagct ggtgaggcct 480 ggggcctcag tgaagatgtc
ctgcaaggct tctggctaca catttaccag ttacaatatg 540 cactgggtaa
agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga 600
aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac tgtagacaaa
660 tcctccagca cagcctacat gcagctcagc agcctgacat ctgaagactc
tgcggtctat 720 ttctgtgcaa gagtggtgta ctatagtaac tcttactggt
acttcgatgt ctggggcaca 780 gggaccacgg tcaccgtctc gagcgagccc
aaatcttctg acaaaactca cacatcccca 840 ccgagcccag cacctgaact
cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 900 aaggacaccc
tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 960
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc
1020 aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag
cgtcctcacc 1080 gtcctgcacc aggactggct gaatggcaag gagtacaagt
gcaaggtctc caacaaagcc 1140 ctcccagccc ccatcgagaa aacaatctcc
aaagccaaag ggcagccccg agaaccacag 1200 gtgtacaccc tgcccccatc
ccgggatgag ctgaccaaga accaggtcag cctgacctgc 1260 ctggtcaaag
gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 1320
gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac
1380 agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc
atgctccgtg 1440 atgcatgagg ctctgcacaa ccactacacg cagaagagcc
tctccctgtc tccgggtaag 1500 aattatggtg gcggtggctc gggcggtggt
ggatctggag gaggtgggag tgggaattct 1560 gacattgtgc tcacccaatc
tccagcttct ttggctgtgt ctctaggtca gagagccacc 1620 atctcctgca
gagccagtga aagtgttgaa tattatgtca caagtttaat gcagtggtac 1680
caacagaaac caggacagcc acccaaactc ctcatctctg ctgctagcaa cgtagaatct
1740 ggggtccctg ccaggtttag tggcagtggg tctgggacag actttagcct
caacatccat 1800 cctgtggagg aggatgatat tgcaatgtat ttctgtcagc
aaagtaggaa ggttccatgg 1860 acgttcggtg gaggcaccaa gctggaaatc
aaacggggtg gcggtggatc cggcggaggt 1920 gggtcgggtg gcggcggatc
tcaggtgcag ctgaaggagt caggacctgg cctggtggcg 1980 ccctcacaga
gcctgtccat cacatgcacc gtctcagggt tctcattaac cggctatggt 2040
gtaaactggg ttcgccagcc tccaggaaag ggtctggagt ggctgggaat gatatggggt
2100 gatggaagca cagactataa ttcagctctc aaatccagac tatcgatcac
caaggacaac 2160 tccaagagcc aagttttctt aaaaatgaac agtctgcaaa
ctgatgacac agccagatac 2220 tactgtgctc gagatggtta tagtaacttt
cattactatg ttatggacta ctggggtcaa 2280 ggaacctcag tcaccgtctc
ctcttaatct aga 2313 <210> SEQ ID NO 215 <211> LENGTH:
764 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
n2H7sssIgG1-STD2-2e12LH (AA) <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Leader <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (21)..(126)
<223> OTHER INFORMATION: VL <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (127)..(142)
<223> OTHER INFORMATION: Linker <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(516) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (517)..(628) <223> OTHER INFORMATION: VL2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (629)..(643) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (644)..(764) <223> OTHER INFORMATION: VH2
<400> SEQUENCE: 215 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190 Ile Tyr
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 210
215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala
Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp
Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330
335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455
460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 495 Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly 500 505 510 Ser Gly Asn Ser Asp Ile Val Leu Thr
Gln Ser Pro Ala Ser Leu Ala 515 520 525 Val Ser Leu Gly Gln Arg Ala
Thr Ile Ser Cys Arg Ala Ser Glu Ser 530 535 540 Val Glu Tyr Tyr Val
Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 545 550 555 560 Gly Gln
Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 565 570 575
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 580
585 590 Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe
Cys 595 600 605 Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly
Thr Lys Leu 610 615 620 Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly 625 630 635 640 Gly Gly Ser Gln Val Gln Leu Lys
Glu Ser Gly Pro Gly Leu Val Ala 645 650 655 Pro Ser Gln Ser Leu Ser
Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 660 665 670 Thr Gly Tyr Gly
Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 675 680 685 Glu Trp
Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser 690 695 700
Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln 705
710 715 720 Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala
Arg Tyr 725 730 735 Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr
Tyr Val Met Asp 740 745 750 Tyr Trp Gly Gln Gly Thr Ser Val Thr Val
Ser Ser 755 760 <210> SEQ ID NO 216 <211> LENGTH: 2048
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
n2H7sssIgG1-H1-2e12HL (DNA) <400> SEQUENCE: 216 aagcttgccg
ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca 60
gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg
120 gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca
ctggtaccag 180 cagaagccag gatcctcccc caaaccctgg atttatgccc
catccaacct ggcttctgga 240 gtccctgctc gcttcagtgg cagtgggtct
gggacctctt actctctcac aatcagcaga 300 gtggaggctg aagatgctgc
cacttattac tgccagcagt ggagttttaa cccacccacg 360 ttcggtgctg
ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct 420
ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct
480 ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag
ttacaatatg 540 cactgggtaa agcagacacc tagacagggc ctggaatgga
ttggagctat ttatccagga 600 aatggtgata cttcctacaa tcagaagttc
aagggcaagg ccacactgac tgtagacaaa 660 tcctccagca cagcctacat
gcagctcagc agcctgacat ctgaagactc tgcggtctat 720 ttctgtgcaa
gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca 780
gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca
840 ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc
cccaaaaccc 900 aaggacaccc tcatgatctc ccggacccct gaggtcacat
gcgtggtggt ggacgtgagc 960 cacgaagacc ctgaggtcaa gttcaactgg
tacgtggacg gcgtggaggt gcataatgcc 1020 aagacaaagc cgcgggagga
gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 1080 gtcctgcacc
aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 1140
ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag
1200 gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag
cctgacctgc 1260 ctggtcaaag gcttctatcc cagcgacatc gccgtggagt
gggagagcaa tgggcagccg 1320 gagaacaact acaagaccac gcctcccgtg
ctggactccg acggctcctt cttcctctac 1380 agcaagctca ccgtggacaa
gagcaggtgg cagcagggga acgtcttctc atgctccgtg 1440 atgcatgagg
ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag 1500
aattctcagg tgcagctgaa ggagtcagga cctggcctgg tggcgccctc acagagcctg
1560 tccatcacat gcaccgtctc agggttctca ttaaccggct atggtgtaaa
ctgggttcgc 1620 cagcctccag gaaagggtct ggagtggctg ggaatgatat
ggggtgatgg aagcacagac 1680 tataattcag ctctcaaatc cagactatcg
atcaccaagg acaactccaa gagccaagtt 1740 ttcttaaaaa tgaacagtct
gcaaactgat gacacagcca gatactactg tgctcgagat 1800 ggttatagta
actttcatta ctatgttatg gactactggg gtcaaggaac ctcagtcacc 1860
gtctcctctg ggggtggagg ctctggtggc ggtggatccg gcggaggtgg gtcgggtggc
1920 ggcggatctg acattgtgct cacccaatct ccagcttctt tggctgtgtc
tctaggtcag 1980 agagccacca tctcctgcag agccagtgaa agtgttgaat
attatgtcac aagtttaatg 2040 cagtggta 2048 <210> SEQ ID NO 217
<211> LENGTH: 751 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: n2H7sssIgG1-H1-2e12HL (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(21)..(126) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(127)..(142) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(498) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (499)..(619) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (620)..(639) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (640)..(751) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 217 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190 Ile Tyr
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 210
215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala
Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp
Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330
335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455
460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 495 Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro
Gly Leu Val Ala Pro 500 505 510 Ser Gln Ser Leu Ser Ile Thr Cys Thr
Val Ser Gly Phe Ser Leu Thr 515 520 525 Gly Tyr Gly Val Asn Trp Val
Arg Gln Pro Pro Gly Lys Gly Leu Glu 530 535 540 Trp Leu Gly Met Ile
Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala 545 550 555 560 Leu Lys
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val 565 570 575
Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr 580
585 590 Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp
Tyr 595 600 605 Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly
Gly Gly Ser 610 615 620 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Asp 625 630 635 640 Ile Val Leu Thr Gln Ser Pro Ala
Ser Leu Ala Val Ser Leu Gly Gln 645 650 655 Arg Ala Thr Ile Ser Cys
Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val 660 665 670 Thr Ser Leu Met
Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 675 680 685 Leu Leu
Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg 690 695 700
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro 705
710 715 720 Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
Arg Lys 725 730 735 Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu
Ile Lys Arg 740 745 750 <210> SEQ ID NO 218 <211>
LENGTH: 2292 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
n2H7sssIgG1-H2-2e12HL (DNA) <400> SEQUENCE: 218 aagcttgccg
ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca 60
gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg
120 gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca
ctggtaccag 180 cagaagccag gatcctcccc caaaccctgg atttatgccc
catccaacct ggcttctgga 240 gtccctgctc gcttcagtgg cagtgggtct
gggacctctt actctctcac aatcagcaga 300 gtggaggctg aagatgctgc
cacttattac tgccagcagt ggagttttaa cccacccacg 360 ttcggtgctg
ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct 420
ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct
480 ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag
ttacaatatg 540 cactgggtaa agcagacacc tagacagggc ctggaatgga
ttggagctat ttatccagga 600 aatggtgata cttcctacaa tcagaagttc
aagggcaagg ccacactgac tgtagacaaa 660 tcctccagca cagcctacat
gcagctcagc agcctgacat ctgaagactc tgcggtctat 720 ttctgtgcaa
gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca 780
gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca
840 ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc
cccaaaaccc 900 aaggacaccc tcatgatctc ccggacccct gaggtcacat
gcgtggtggt ggacgtgagc 960 cacgaagacc ctgaggtcaa gttcaactgg
tacgtggacg gcgtggaggt gcataatgcc 1020 aagacaaagc cgcgggagga
gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 1080 gtcctgcacc
aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 1140
ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag
1200 gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag
cctgacctgc 1260 ctggtcaaag gcttctatcc cagcgacatc gccgtggagt
gggagagcaa tgggcagccg 1320 gagaacaact acaagaccac gcctcccgtg
ctggactccg acggctcctt cttcctctac 1380 agcaagctca ccgtggacaa
gagcaggtgg cagcagggga acgtcttctc atgctccgtg 1440 atgcatgagg
ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag 1500
ggtggcggtg gctcggggaa ttctcaggtg cagctgaagg agtcaggacc tggcctggtg
1560 gcgccctcac agagcctgtc catcacatgc accgtctcag ggttctcatt
aaccggctat 1620 ggtgtaaact gggttcgcca gcctccagga aagggtctgg
agtggctggg aatgatatgg 1680 ggtgatggaa gcacagacta taattcagct
ctcaaatcca gactatcgat caccaaggac 1740 aactccaaga gccaagtttt
cttaaaaatg aacagtctgc aaactgatga cacagccaga 1800 tactactgtg
ctcgagatgg ttatagtaac tttcattact atgttatgga ctactggggt 1860
caaggaacct cagtcaccgt ctcctctggg ggtggaggct ctggtggcgg tggatccggc
1920 ggaggtgggt cgggtggcgg cggatctgac attgtgctca cccaatctcc
agcttctttg 1980 gctgtgtctc taggtcagag agccaccatc tcctgcagag
ccagtgaaag tgttgaatat 2040 tatgtcacaa gtttaatgca gtggtaccaa
cagaaaccag gacagccacc caaactcctc 2100 atctctgctg ctagcaacgt
agaatctggg gtccctgcca ggtttagtgg cagtgggtct 2160 gggacagact
ttagcctcaa catccatcct gtggaggagg atgatattgc aatgtatttc 2220
tgtcagcaaa gtaggaaggt tccatggacg ttcggtggag gcaccaagct ggaaatcaaa
2280 cgttaatcta ga 2292 <210> SEQ ID NO 219 <211>
LENGTH: 757 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
n2H7sssIgG1-H2-2e12HL (AA) <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Leader <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (21)..(126)
<223> OTHER INFORMATION: VL <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (127)..(142)
<223> OTHER INFORMATION: Linker <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(504) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (505)..(625) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (626)..(645) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (646)..(757) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 219 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190 Ile Tyr
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 210
215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala
Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp
Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330
335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455
460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 495 Gly Gly Gly Gly Ser Gly Asn Ser Gln Val Gln
Leu Lys Glu Ser Gly 500 505 510 Pro Gly Leu Val Ala Pro Ser Gln Ser
Leu Ser Ile Thr Cys Thr Val 515 520 525 Ser Gly Phe Ser Leu Thr Gly
Tyr Gly Val Asn Trp Val Arg Gln Pro 530 535 540 Pro Gly Lys Gly Leu
Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser 545 550 555 560 Thr Asp
Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp 565 570 575
Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp 580
585 590 Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe
His 595 600 605 Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
Thr Val Ser 610 615 620 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 625 630 635 640 Gly Gly Gly Gly Ser Asp Ile Val
Leu Thr Gln Ser Pro Ala Ser Leu 645 650 655 Ala Val Ser Leu Gly Gln
Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 660 665 670 Ser Val Glu Tyr
Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys 675 680 685 Pro Gly
Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu 690 695 700
Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 705
710 715 720 Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met
Tyr Phe 725 730 735 Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly
Gly Gly Thr Lys 740 745 750 Leu Glu Ile Lys Arg 755 <210> SEQ
ID NO 220 <211> LENGTH: 2298 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: n2H7sssIgG1-H3-2e12HL (DNA)
<400> SEQUENCE: 220 aagcttgccg ccatggaagc accagcgcag
cttctcttcc tcctgctact ctggctccca 60 gataccaccg gtcaaattgt
tctctcccag tctccagcaa tcctgtctgc atctccaggg 120 gagaaggtca
caatgacttg cagggccagc tcaagtgtaa gttacatgca ctggtaccag 180
cagaagccag gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga
240 gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac
aatcagcaga 300 gtggaggctg aagatgctgc cacttattac tgccagcagt
ggagttttaa cccacccacg 360 ttcggtgctg ggaccaagct ggagctgaaa
gatggcggtg gctcgggcgg tggtggatct 420 ggaggaggtg gagctagcca
ggcttatcta cagcagtctg gggctgagct ggtgaggcct 480 ggggcctcag
tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg 540
cactgggtaa agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga
600 aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac
tgtagacaaa 660 tcctccagca cagcctacat gcagctcagc agcctgacat
ctgaagactc tgcggtctat 720 ttctgtgcaa gagtggtgta ctatagtaac
tcttactggt acttcgatgt ctggggcaca 780 gggaccacgg tcaccgtctc
gagcgagccc aaatcttctg acaaaactca cacatcccca 840 ccgagcccag
cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 900
aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc
960 cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt
gcataatgcc 1020 aagacaaagc cgcgggagga gcagtacaac agcacgtacc
gtgtggtcag cgtcctcacc 1080 gtcctgcacc aggactggct gaatggcaag
gagtacaagt gcaaggtctc caacaaagcc 1140 ctcccagccc ccatcgagaa
aacaatctcc aaagccaaag ggcagccccg agaaccacag 1200 gtgtacaccc
tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc 1260
ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg
1320 gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt
cttcctctac 1380 agcaagctca ccgtggacaa gagcaggtgg cagcagggga
acgtcttctc atgctccgtg 1440 atgcatgagg ctctgcacaa ccactacacg
cagaagagcc tctccctgtc tccgggtaag 1500 aattatggtg gcggtggctc
tgggaattct caggtgcagc tgaaggagtc aggacctggc 1560 ctggtggcgc
cctcacagag cctgtccatc acatgcaccg tctcagggtt ctcattaacc 1620
ggctatggtg taaactgggt tcgccagcct ccaggaaagg gtctggagtg gctgggaatg
1680 atatggggtg atggaagcac agactataat tcagctctca aatccagact
atcgatcacc 1740 aaggacaact ccaagagcca agttttctta aaaatgaaca
gtctgcaaac tgatgacaca 1800 gccagatact actgtgctcg agatggttat
agtaactttc attactatgt tatggactac 1860 tggggtcaag gaacctcagt
caccgtctcc tctgggggtg gaggctctgg tggcggtgga 1920 tccggcggag
gtgggtcggg tggcggcgga tctgacattg tgctcaccca atctccagct 1980
tctttggctg tgtctctagg tcagagagcc accatctcct gcagagccag tgaaagtgtt
2040 gaatattatg tcacaagttt aatgcagtgg taccaacaga aaccaggaca
gccacccaaa 2100 ctcctcatct ctgctgctag caacgtagaa tctggggtcc
ctgccaggtt tagtggcagt 2160 gggtctggga cagactttag cctcaacatc
catcctgtgg aggaggatga tattgcaatg 2220 tatttctgtc agcaaagtag
gaaggttcca tggacgttcg gtggaggcac caagctggaa 2280 atcaaacgtt
aatctaga 2298 <210> SEQ ID NO 221 <211> LENGTH: 759
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
n2H7sssIgG1-H3-2e12HL (AA) <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Leader <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (21)..(126)
<223> OTHER INFORMATION: VL <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (127)..(142)
<223> OTHER INFORMATION: Linker <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(506) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (507)..(627) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (628)..(647) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (648)..(759) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 221 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190 Ile Tyr
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 210
215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala
Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp
Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330
335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455
460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 495 Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser Gln
Val Gln Leu Lys Glu 500 505 510 Ser Gly Pro Gly Leu Val Ala Pro Ser
Gln Ser Leu Ser Ile Thr Cys 515 520 525 Thr Val Ser Gly Phe Ser Leu
Thr Gly Tyr Gly Val Asn Trp Val Arg 530 535 540 Gln Pro Pro Gly Lys
Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp 545 550 555 560 Gly Ser
Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr 565 570 575
Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 580
585 590 Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser
Asn 595 600 605 Phe His Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr
Ser Val Thr 610 615 620 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly 625 630 635 640 Gly Ser Gly Gly Gly Gly Ser Asp
Ile Val Leu Thr Gln Ser Pro Ala 645 650 655 Ser Leu Ala Val Ser Leu
Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 660 665 670 Ser Glu Ser Val
Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln 675 680 685 Gln Lys
Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 690 695 700
Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 705
710 715 720 Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile
Ala Met 725 730 735 Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr
Phe Gly Gly Gly 740 745 750 Thr Lys Leu Glu Ile Lys Arg 755
<210> SEQ ID NO 222 <211> LENGTH: 2307 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: n2H7sssIgG1-H4-2e12HL (DNA)
<400> SEQUENCE: 222 aagcttgccg ccatggaagc accagcgcag
cttctcttcc tcctgctact ctggctccca 60 gataccaccg gtcaaattgt
tctctcccag tctccagcaa tcctgtctgc atctccaggg 120 gagaaggtca
caatgacttg cagggccagc tcaagtgtaa gttacatgca ctggtaccag 180
cagaagccag gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga
240 gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac
aatcagcaga 300 gtggaggctg aagatgctgc cacttattac tgccagcagt
ggagttttaa cccacccacg 360 ttcggtgctg ggaccaagct ggagctgaaa
gatggcggtg gctcgggcgg tggtggatct 420 ggaggaggtg gagctagcca
ggcttatcta cagcagtctg gggctgagct ggtgaggcct 480 ggggcctcag
tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg 540
cactgggtaa agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga
600 aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac
tgtagacaaa 660 tcctccagca cagcctacat gcagctcagc agcctgacat
ctgaagactc tgcggtctat 720 ttctgtgcaa gagtggtgta ctatagtaac
tcttactggt acttcgatgt ctggggcaca 780 gggaccacgg tcaccgtctc
gagcgagccc aaatcttctg acaaaactca cacatcccca 840 ccgagcccag
cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 900
aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc
960 cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt
gcataatgcc 1020 aagacaaagc cgcgggagga gcagtacaac agcacgtacc
gtgtggtcag cgtcctcacc 1080 gtcctgcacc aggactggct gaatggcaag
gagtacaagt gcaaggtctc caacaaagcc 1140 ctcccagccc ccatcgagaa
aacaatctcc aaagccaaag ggcagccccg agaaccacag 1200 gtgtacaccc
tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc 1260
ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg
1320 gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt
cttcctctac 1380 agcaagctca ccgtggacaa gagcaggtgg cagcagggga
acgtcttctc atgctccgtg 1440 atgcatgagg ctctgcacaa ccactacacg
cagaagagcc tctccctgtc tccgggtaag 1500 ggtggcggtg gctcgggcgg
tggtggatct gggaattctc aggtgcagct gaaggagtca 1560 ggacctggcc
tggtggcgcc ctcacagagc ctgtccatca catgcaccgt ctcagggttc 1620
tcattaaccg gctatggtgt aaactgggtt cgccagcctc caggaaaggg tctggagtgg
1680 ctgggaatga tatggggtga tggaagcaca gactataatt cagctctcaa
atccagacta 1740 tcgatcacca aggacaactc caagagccaa gttttcttaa
aaatgaacag tctgcaaact 1800 gatgacacag ccagatacta ctgtgctcga
gatggttata gtaactttca ttactatgtt 1860 atggactact ggggtcaagg
aacctcagtc accgtctcct ctgggggtgg aggctctggt 1920 ggcggtggat
ccggcggagg tgggtcgggt ggcggcggat ctgacattgt gctcacccaa 1980
tctccagctt ctttggctgt gtctctaggt cagagagcca ccatctcctg cagagccagt
2040 gaaagtgttg aatattatgt cacaagttta atgcagtggt accaacagaa
accaggacag 2100 ccacccaaac tcctcatctc tgctgctagc aacgtagaat
ctggggtccc tgccaggttt 2160 agtggcagtg ggtctgggac agactttagc
ctcaacatcc atcctgtgga ggaggatgat 2220 attgcaatgt atttctgtca
gcaaagtagg aaggttccat ggacgttcgg tggaggcacc 2280 aagctggaaa
tcaaacgtta atctaga 2307 <210> SEQ ID NO 223 <211>
LENGTH: 762 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
n2H7sssIgG1-H4-2e12HL (AA) <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Leader <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (21)..(126)
<223> OTHER INFORMATION: VL <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (127)..(142)
<223> OTHER INFORMATION: Linker <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(509) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (510)..(630) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (631)..(650) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (651)..(762) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 223 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190 Ile Tyr
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 210
215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala
Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp
Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330
335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455
460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 495 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Asn Ser Gln Val Gln 500 505 510 Leu Lys Glu Ser Gly Pro Gly Leu Val
Ala Pro Ser Gln Ser Leu Ser 515 520 525 Ile Thr Cys Thr Val Ser Gly
Phe Ser Leu Thr Gly Tyr Gly Val Asn 530 535 540 Trp Val Arg Gln Pro
Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile 545 550 555 560 Trp Gly
Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu 565 570 575
Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 580
585 590 Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp
Gly 595 600 605 Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly
Gln Gly Thr 610 615 620 Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 625 630 635 640 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Asp Ile Val Leu Thr Gln 645 650 655 Ser Pro Ala Ser Leu Ala
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 660 665 670 Cys Arg Ala Ser
Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln 675 680 685 Trp Tyr
Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala 690 695 700
Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 705
710 715 720 Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu
Asp Asp 725 730 735 Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val
Pro Trp Thr Phe 740 745 750 Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
755 760 <210> SEQ ID NO 224 <211> LENGTH: 2313
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
n2H7sssIgG1-H5-2e12HL (DNA) <400> SEQUENCE: 224 aagcttgccg
ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca 60
gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg
120 gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca
ctggtaccag 180 cagaagccag gatcctcccc caaaccctgg atttatgccc
catccaacct ggcttctgga 240 gtccctgctc gcttcagtgg cagtgggtct
gggacctctt actctctcac aatcagcaga 300 gtggaggctg aagatgctgc
cacttattac tgccagcagt ggagttttaa cccacccacg 360 ttcggtgctg
ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct 420
ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct
480 ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag
ttacaatatg 540 cactgggtaa agcagacacc tagacagggc ctggaatgga
ttggagctat ttatccagga 600 aatggtgata cttcctacaa tcagaagttc
aagggcaagg ccacactgac tgtagacaaa 660 tcctccagca cagcctacat
gcagctcagc agcctgacat ctgaagactc tgcggtctat 720 ttctgtgcaa
gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca 780
gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca
840 ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc
cccaaaaccc 900 aaggacaccc tcatgatctc ccggacccct gaggtcacat
gcgtggtggt ggacgtgagc 960 cacgaagacc ctgaggtcaa gttcaactgg
tacgtggacg gcgtggaggt gcataatgcc 1020 aagacaaagc cgcgggagga
gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 1080 gtcctgcacc
aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 1140
ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag
1200 gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag
cctgacctgc 1260 ctggtcaaag gcttctatcc cagcgacatc gccgtggagt
gggagagcaa tgggcagccg 1320 gagaacaact acaagaccac gcctcccgtg
ctggactccg acggctcctt cttcctctac 1380 agcaagctca ccgtggacaa
gagcaggtgg cagcagggga acgtcttctc atgctccgtg 1440 atgcatgagg
ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag 1500
aattatggtg gcggtggctc gggcggtggt ggatctggga attctcaggt gcagctgaag
1560 gagtcaggac ctggcctggt ggcgccctca cagagcctgt ccatcacatg
caccgtctca 1620 gggttctcat taaccggcta tggtgtaaac tgggttcgcc
agcctccagg aaagggtctg 1680 gagtggctgg gaatgatatg gggtgatgga
agcacagact ataattcagc tctcaaatcc 1740 agactatcga tcaccaagga
caactccaag agccaagttt tcttaaaaat gaacagtctg 1800 caaactgatg
acacagccag atactactgt gctcgagatg gttatagtaa ctttcattac 1860
tatgttatgg actactgggg tcaaggaacc tcagtcaccg tctcctctgg gggtggaggc
1920 tctggtggcg gtggatccgg cggaggtggg tcgggtggcg gcggatctga
cattgtgctc 1980 acccaatctc cagcttcttt ggctgtgtct ctaggtcaga
gagccaccat ctcctgcaga 2040 gccagtgaaa gtgttgaata ttatgtcaca
agtttaatgc agtggtacca acagaaacca 2100 ggacagccac ccaaactcct
catctctgct gctagcaacg tagaatctgg ggtccctgcc 2160 aggtttagtg
gcagtgggtc tgggacagac tttagcctca acatccatcc tgtggaggag 2220
gatgatattg caatgtattt ctgtcagcaa agtaggaagg ttccatggac gttcggtgga
2280 ggcaccaagc tggaaatcaa acgttaatct aga 2313 <210> SEQ ID
NO 225 <211> LENGTH: 764 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: n2H7sssIgG1-H5-2e12HL (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(21)..(126) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(127)..(142) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(511) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (512)..(632) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (633)..(652) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (653)..(764) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 225 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190 Ile Tyr
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 210
215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala
Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp
Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330
335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455
460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 495 Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Asn Ser Gln 500 505 510 Val Gln Leu Lys Glu Ser Gly Pro Gly
Leu Val Ala Pro Ser Gln Ser 515 520 525 Leu Ser Ile Thr Cys Thr Val
Ser Gly Phe Ser Leu Thr Gly Tyr Gly 530 535 540 Val Asn Trp Val Arg
Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 545 550 555 560 Met Ile
Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser 565 570 575
Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 580
585 590 Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
Arg 595 600 605 Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr
Trp Gly Gln 610 615 620 Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly 625 630 635 640 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Asp Ile Val Leu 645 650 655 Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly Gln Arg Ala Thr 660 665 670 Ile Ser Cys Arg
Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu 675 680 685 Met Gln
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 690 695 700
Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly 705
710 715 720 Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val
Glu Glu 725 730 735 Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg
Lys Val Pro Trp 740 745 750 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
Lys Arg 755 760 <210> SEQ ID NO 226 <211> LENGTH: 2322
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
n2H7sssIgG1-H6-2e12HL (DNA) <400> SEQUENCE: 226 aagcttgccg
ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca 60
gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg
120 gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca
ctggtaccag 180 cagaagccag gatcctcccc caaaccctgg atttatgccc
catccaacct ggcttctgga 240 gtccctgctc gcttcagtgg cagtgggtct
gggacctctt actctctcac aatcagcaga 300 gtggaggctg aagatgctgc
cacttattac tgccagcagt ggagttttaa cccacccacg 360 ttcggtgctg
ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct 420
ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct
480 ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag
ttacaatatg 540 cactgggtaa agcagacacc tagacagggc ctggaatgga
ttggagctat ttatccagga 600 aatggtgata cttcctacaa tcagaagttc
aagggcaagg ccacactgac tgtagacaaa 660 tcctccagca cagcctacat
gcagctcagc agcctgacat ctgaagactc tgcggtctat 720 ttctgtgcaa
gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca 780
gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca
840 ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc
cccaaaaccc 900 aaggacaccc tcatgatctc ccggacccct gaggtcacat
gcgtggtggt ggacgtgagc 960 cacgaagacc ctgaggtcaa gttcaactgg
tacgtggacg gcgtggaggt gcataatgcc 1020 aagacaaagc cgcgggagga
gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 1080 gtcctgcacc
aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 1140
ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag
1200 gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag
cctgacctgc 1260 ctggtcaaag gcttctatcc cagcgacatc gccgtggagt
gggagagcaa tgggcagccg 1320 gagaacaact acaagaccac gcctcccgtg
ctggactccg acggctcctt cttcctctac 1380 agcaagctca ccgtggacaa
gagcaggtgg cagcagggga acgtcttctc atgctccgtg 1440 atgcatgagg
ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag 1500
ggtggcggtg gctcgggcgg tggtggatct gggggaggag gcagcgggaa ttctcaggtg
1560 cagctgaagg agtcaggacc tggcctggtg gcgccctcac agagcctgtc
catcacatgc 1620 accgtctcag ggttctcatt aaccggctat ggtgtaaact
gggttcgcca gcctccagga 1680 aagggtctgg agtggctggg aatgatatgg
ggtgatggaa gcacagacta taattcagct 1740 ctcaaatcca gactatcgat
caccaaggac aactccaaga gccaagtttt cttaaaaatg 1800 aacagtctgc
aaactgatga cacagccaga tactactgtg ctcgagatgg ttatagtaac 1860
tttcattact atgttatgga ctactggggt caaggaacct cagtcaccgt ctcctctggg
1920 ggtggaggct ctggtggcgg tggatccggc ggaggtgggt cgggtggcgg
cggatctgac 1980 attgtgctca cccaatctcc agcttctttg gctgtgtctc
taggtcagag agccaccatc 2040 tcctgcagag ccagtgaaag tgttgaatat
tatgtcacaa gtttaatgca gtggtaccaa 2100 cagaaaccag gacagccacc
caaactcctc atctctgctg ctagcaacgt agaatctggg 2160 gtccctgcca
ggtttagtgg cagtgggtct gggacagact ttagcctcaa catccatcct 2220
gtggaggagg atgatattgc aatgtatttc tgtcagcaaa gtaggaaggt tccatggacg
2280 ttcggtggag gcaccaagct ggaaatcaaa cgttaatcta ga 2322
<210> SEQ ID NO 227 <211> LENGTH: 767 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: n2H7sssIgG1-H6-2e12HL (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(20) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (21)..(126) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(127)..(142) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(514) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (515)..(635) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (636)..(655) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (656)..(767) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 227 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190 Ile Tyr
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 210
215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala
Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp
Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330
335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455
460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 495 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 500 505 510 Asn Ser Gln Val Gln Leu Lys Glu Ser
Gly Pro Gly Leu Val Ala Pro 515 520 525 Ser Gln Ser Leu Ser Ile Thr
Cys Thr Val Ser Gly Phe Ser Leu Thr 530 535 540 Gly Tyr Gly Val Asn
Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 545 550 555 560 Trp Leu
Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala 565 570 575
Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val 580
585 590 Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr
Tyr 595 600 605 Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val
Met Asp Tyr 610 615 620 Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
Gly Gly Gly Gly Ser 625 630 635 640 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Asp 645 650 655 Ile Val Leu Thr Gln Ser
Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 660 665 670 Arg Ala Thr Ile
Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val 675 680 685 Thr Ser
Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 690 695 700
Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg 705
710 715 720 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile
His Pro 725 730 735 Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln
Gln Ser Arg Lys 740 745 750 Val Pro Trp Thr Phe Gly Gly Gly Thr Lys
Leu Glu Ile Lys Arg 755 760 765 <210> SEQ ID NO 228
<211> LENGTH: 2337 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-H7-G281 HL (DNA) <400>
SEQUENCE: 228 aagcttgccg ccatggattt tcaagtgcag attttcagct
tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc
tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat
gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga
agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct 240
tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc
300 agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag
ttttaaccca 360 cccacgttcg gtgctgggac caagctggag ctgaaagatg
gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct
tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa
gatgtcctgc aaggcttctg gctacacatt taccagttac 540 aatatgcact
gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat 600
ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta
660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga
agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat agtaactctt
actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat
caggagccca aatcttgtga caaaactcac 840 acatccccac cgtgctcagc
acctgaactc ctggggggac cgtcagtctt cctcttcccc 900 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 960
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa
acaatctcca aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc
tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1320
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc
1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa
cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc
agaagagcct ctccctgtct 1500 ccgggtaaga attatggtgg cggtggctcg
ggcggtggtg gatctggagg aggtgggagt 1560 gggaattctc aggtgcagct
gaaggagtca ggacctggcc tggtggcgcc ctcacagagc 1620 ctgtccatca
catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt 1680
cgccagcctc caggaaaggg tctggagtgg ctgggaatga tatggggtga tggaagcaca
1740 gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc
caagagccaa 1800 gttttcttaa aaatgaacag tctgcaaact gatgacacag
ccagatacta ctgtgctcga 1860 gatggttata gtaactttca ttactatgtt
atggactact ggggtcaagg aacctcagtc 1920 accgtctcct ctgggggtgg
aggctctggt ggcggtggat ccggcggagg tgggtcgggt 1980 ggcggcggat
ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt 2040
cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta
2100 atgcagtggt accaacagaa accaggacag ccacccaaac tcctcatctc
tgctgctagc 2160 aacgtagaat ctggggtccc tgccaggttt agtggcagtg
ggtctgggac agactttagc 2220 ctcaacatcc atcctgtgga ggaggatgat
attgcaatgt atttctgtca gcaaagtagg 2280 aaggttccat ggacgttcgg
tggaggcacc aagctggaaa tcaaacgtta atctaga 2337 <210> SEQ ID NO
229 <211> LENGTH: 772 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7cscIgG1-STD1-2e12HL (w/2E12 leader) (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(22) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (23)..(128) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(519) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (520)..(640) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (641)..(660) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (661)..(772) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 229 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Cys 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Cys Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Ser Gln Val
Gln Leu Lys Glu Ser Gly Pro 515 520 525 Gly Leu Val Ala Pro Ser Gln
Ser Leu Ser Ile Thr Cys Thr Val Ser 530 535 540 Gly Phe Ser Leu Thr
Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 545 550 555 560 Gly Lys
Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 565 570 575
Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 580
585 590 Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp
Asp 595 600 605 Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn
Phe His Tyr 610 615 620 Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser
Val Thr Val Ser Ser 625 630 635 640 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly 645 650 655 Gly Gly Gly Ser Asp Ile
Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 660 665 670 Val Ser Leu Gly
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 675 680 685 Val Glu
Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 690 695 700
Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 705
710 715 720 Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Ser 725 730 735 Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala
Met Tyr Phe Cys 740 745 750 Gln Gln Ser Arg Lys Val Pro Trp Thr Phe
Gly Gly Gly Thr Lys Leu 755 760 765 Glu Ile Lys Arg 770 <210>
SEQ ID NO 230 <211> LENGTH: 45 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scs(s) -hIgG1 (DNA) <400>
SEQUENCE: 230 gagcccaaat cttctgacaa aactcacaca tctccaccga gctca 45
<210> SEQ ID NO 231 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - scs(s)
-hIgG1 (AA) <400> SEQUENCE: 231 Glu Pro Lys Ser Ser Asp Lys
Thr His Thr Ser Pro Pro Ser Ser 1 5 10 15 <210> SEQ ID NO 232
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - ccc(s) (DNA)
<400> SEQUENCE: 232 gagcccaaat cttgtgacaa aactcacaca
tctccaccgt gctca 45 <210> SEQ ID NO 233 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - ccc(s) (AA) <400> SEQUENCE: 233 Glu Pro Lys Ser Cys
Asp Lys Thr His Thr Ser Pro Pro Cys Ser 1 5 10 15 <210> SEQ
ID NO 234 <211> LENGTH: 24 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker polynucleotide - Linker
H8 (PN) <400> SEQUENCE: 234 gggtctccac cttctccgaa ttct 24
<210> SEQ ID NO 235 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker <400>
SEQUENCE: 235 Gly Ser Pro Pro Ser Pro Asn Ser 1 5 <210> SEQ
ID NO 236 <211> LENGTH: 21 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker polynucleotide - Linker
H9 (PN) <400> SEQUENCE: 236 tctccacctt ctccgaattc t 21
<210> SEQ ID NO 237 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H9
(AA) <400> SEQUENCE: 237 Ser Pro Pro Ser Pro Asn Ser 1 5
<210> SEQ ID NO 238 <400> SEQUENCE: 238 000 <210>
SEQ ID NO 239 <400> SEQUENCE: 239 000 <210> SEQ ID NO
240 <211> LENGTH: 51 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker polynucleotide - Linker
H11 (PN) <400> SEQUENCE: 240 gagcccacat ctaccgacaa aactcacaca
tctccaccca gcccgaattc t 51 <210> SEQ ID NO 241 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H11 (AA) <400> SEQUENCE: 241
Glu Pro Thr Ser Thr Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asn 1 5
10 15 Ser <210> SEQ ID NO 242 <211> LENGTH: 51
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker polynucleotide - Linker H12 (PN) <400> SEQUENCE: 242
gagcccacat ctaccgacaa aactcacaca tctccaccca gcccgaattc t 51
<210> SEQ ID NO 243 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H12
(AA) <400> SEQUENCE: 243 Glu Pro Thr Ser Thr Asp Lys Thr His
Thr Cys Pro Pro Cys Pro Asn 1 5 10 15 Ser <210> SEQ ID NO 244
<211> LENGTH: 51 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H13
(PN) <400> SEQUENCE: 244 gagcccacat ctaccgacaa aactcacaca
tctccaccca gcccgaattc t 51 <210> SEQ ID NO 245 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H13 (AA) <400> SEQUENCE: 245
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 1 5
10 15 Ser <210> SEQ ID NO 246 <211> LENGTH: 36
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker polynucleotide - Linker H15 (PN) <400> SEQUENCE: 246
ggcggtggtg gctcctgtcc accttgtccg aattct 36 <210> SEQ ID NO
247 <211> LENGTH: 12 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker - Linker H15 (AA)
<400> SEQUENCE: 247 Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro
Asn Ser 1 5 10 <210> SEQ ID NO 248 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker polynucleotide - Linker H16 (PN) <400> SEQUENCE: 248
ctgtctgtga aagctgactt cctcactcca tccatcggga attct 45 <210>
SEQ ID NO 249 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H16
(AA) <400> SEQUENCE: 249 Leu Ser Val Lys Ala Asp Phe Leu Thr
Pro Ser Ile Gly Asn Ser 1 5 10 15 <210> SEQ ID NO 250
<211> LENGTH: 60 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H17
(PN) <400> SEQUENCE: 250 ctgtctgtga aagctgactt cctcactcca
tccatctcct gtccaccttg cccgaattct 60 <210> SEQ ID NO 251
<211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker - Linker H17 (AA) <400>
SEQUENCE: 251 Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser
Cys Pro Pro 1 5 10 15 Cys Pro Asn Ser 20 <210> SEQ ID NO 252
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H18
(PN) <400> SEQUENCE: 252 ctgtctgtgc tcgctaactt cagtcagcca
gagatcggga attct 45 <210> SEQ ID NO 253 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H18 (AA) <400> SEQUENCE: 253 Leu Ser Val Leu
Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 1 5 10 15 <210>
SEQ ID NO 254 <211> LENGTH: 60 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H19 (PN) <400> SEQUENCE: 254
ctgtctgtgc tcgctaactt cagtcagcca gagatctcct gtccaccttg cccgaattct
60 <210> SEQ ID NO 255 <211> LENGTH: 20 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Scorpion region linker -
Linker H19 (AA) <400> SEQUENCE: 255 Leu Ser Val Leu Ala Asn
Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro 1 5 10 15 Cys Pro Asn Ser
20 <210> SEQ ID NO 256 <211> LENGTH: 45 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H20 (PN) <400> SEQUENCE: 256
ctgaaaatcc aggagagggt cagtaagcca aagatctcga attct 45 <210>
SEQ ID NO 257 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H20
(AA) <400> SEQUENCE: 257 Leu Lys Ile Gln Glu Arg Val Ser Lys
Pro Lys Ile Ser Asn Ser 1 5 10 15 <210> SEQ ID NO 258
<211> LENGTH: 60 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polypeptide - Linker H21 (PN)
<400> SEQUENCE: 258 ctgaaaatcc aggagagggt cagtaagcca
aagatctcct gtccaccttg cccgaattct 60 <210> SEQ ID NO 259
<211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker - Linker H21 (AA) <400>
SEQUENCE: 259 Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser
Cys Pro Pro 1 5 10 15 Cys Pro Asn Ser 20 <210> SEQ ID NO 260
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polypeptide - Linker H22 (PN)
<400> SEQUENCE: 260 ctggatgtga gtgagaggcc ttttcctcca
cacatccaga attct 45 <210> SEQ ID NO 261 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H22 (AA) <400> SEQUENCE: 261 Leu Asp Val Ser
Glu Arg Pro Phe Pro Pro His Ile Gln Asn Ser 1 5 10 15 <210>
SEQ ID NO 262 <211> LENGTH: 63 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H23 (PN) <400> SEQUENCE: 262
ctggatgtga gtgagaggcc ttttcctcca cacatccagt cctgtccacc ttgcccgaat
60 tct 63 <210> SEQ ID NO 263 <211> LENGTH: 21
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H23 (AA) <400> SEQUENCE: 263 Leu Asp Val Ser
Glu Arg Pro Phe Pro Pro His Ile Gln Ser Cys Pro 1 5 10 15 Pro Cys
Pro Asn Ser 20 <210> SEQ ID NO 264 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker polynucleotide - Linker H24 (DNA) <400> SEQUENCE: 264
cgggaacagc tggcagaggt cactttgagc ttgaaagcga attct 45 <210>
SEQ ID NO 265 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H24
(AA) <400> SEQUENCE: 265 Arg Glu Gln Leu Ala Glu Val Thr Leu
Ser Leu Lys Ala Asn Ser 1 5 10 15 <210> SEQ ID NO 266
<211> LENGTH: 60 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H25
(PN) <400> SEQUENCE: 266 cgggaacagc tggcagaggt cactttgagc
gtgaaagctt gtccaccctg cccgaattct 60 <210> SEQ ID NO 267
<211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker - Linker H25 (AA) <400>
SEQUENCE: 267 Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala
Cys Pro Pro 1 5 10 15 Cys Pro Asn Ser 20 <210> SEQ ID NO 268
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H26
(PN) <400> SEQUENCE: 268 cggattcacc agatgaactc cgagttgagc
gtgctcgcga attct 45 <210> SEQ ID NO 269 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H26 (AA) <400> SEQUENCE: 269 Arg Ile His Gln
Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 1 5 10 15 <210>
SEQ ID NO 270 <211> LENGTH: 60 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H27 (PN) <400> SEQUENCE: 270
cggattcacc agatgaactc cgagttgagc gtgctcgctt gtccaccctg cccgaattct
60 <210> SEQ ID NO 271 <211> LENGTH: 20 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Scorpion region linker -
Linker H27 (AA) <400> SEQUENCE: 271 Arg Ile His Gln Met Asn
Ser Glu Leu Ser Val Leu Ala Cys Pro Pro 1 5 10 15 Cys Pro Asn Ser
20 <210> SEQ ID NO 272 <211> LENGTH: 45 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H28 (PN) <400> SEQUENCE: 272
gataccaaag ggaagaacgt cctcgagaag atcttctcga attct 45 <210>
SEQ ID NO 273 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H28
(AA) <400> SEQUENCE: 273 Asp Thr Lys Gly Lys Asn Val Leu Glu
Lys Ile Phe Ser Asn Ser 1 5 10 15 <210> SEQ ID NO 274
<211> LENGTH: 63 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H29
(PN) <400> SEQUENCE: 274 gataccaaag ggaagaacgt cctcgagaag
atcttcgact cctgtccacc ttgcccgaat 60 tct 63 <210> SEQ ID NO
275 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker - Linker H29 (AA)
<400> SEQUENCE: 275 Asp Thr Lys Gly Lys Asn Val Leu Glu Lys
Ile Phe Asp Ser Cys Pro 1 5 10 15 Pro Cys Pro Asn Ser 20
<210> SEQ ID NO 276 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H30 (PN) <400> SEQUENCE: 276
ctgccacctg agacacagga gagtcaagaa gtcaccctga attct 45 <210>
SEQ ID NO 277 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H30
(AA) <400> SEQUENCE: 277 Leu Pro Pro Glu Thr Gln Glu Ser Gln
Glu Val Thr Leu Asn Ser 1 5 10 15 <210> SEQ ID NO 278
<211> LENGTH: 63 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H31
(PN) <400> SEQUENCE: 278 ctgccacctg agacacagga gagtcaagaa
gtcaccctgt cctgtccacc ttgcccgaat 60 tct 63 <210> SEQ ID NO
279 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker - Linker H31 (AA)
<400> SEQUENCE: 279 Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu
Val Thr Leu Ser Cys Pro 1 5 10 15 Pro Cys Pro Asn Ser 20
<210> SEQ ID NO 280 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H32 (PN) <400> SEQUENCE: 280
cggattcacc tgaacgtgtc cgagaggccc tttcctccga attct 45 <210>
SEQ ID NO 281 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H32
(AA) <400> SEQUENCE: 281 Arg Ile His Leu Asn Val Ser Glu Arg
Pro Phe Pro Pro Asn Ser 1 5 10 15 <210> SEQ ID NO 282
<211> LENGTH: 60 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H33
(PN) <400> SEQUENCE: 282 cggattcacc tgaacgtgtc cgagaggccc
tttcctccct gtccaccctg cccgaattct 60 <210> SEQ ID NO 283
<211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker - Linker H33 (AA) <400>
SEQUENCE: 283 Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro
Cys Pro Pro 1 5 10 15 Cys Pro Asn Ser 20 <210> SEQ ID NO 284
<400> SEQUENCE: 284 000 <210> SEQ ID NO 285 <400>
SEQUENCE: 285 000 <210> SEQ ID NO 286 <400> SEQUENCE:
286 000 <210> SEQ ID NO 287 <400> SEQUENCE: 287 000
<210> SEQ ID NO 288 <211> LENGTH: 39 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H36
(PN) <400> SEQUENCE: 288 gggtgtccac cttgtccagg cggtggtgga
tcgaattct 39 <210> SEQ ID NO 289 <211> LENGTH: 13
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H36 (AA) <400> SEQUENCE: 289 Gly Cys Pro Pro
Cys Pro Gly Gly Gly Gly Ser Asn Ser 1 5 10 <210> SEQ ID NO
290 <400> SEQUENCE: 290 000 <210> SEQ ID NO 291
<400> SEQUENCE: 291 000 <210> SEQ ID NO 292 <400>
SEQUENCE: 292 000 <210> SEQ ID NO 293 <400> SEQUENCE:
293 000 <210> SEQ ID NO 294 <400> SEQUENCE: 294 000
<210> SEQ ID NO 295 <400> SEQUENCE: 295 000 <210>
SEQ ID NO 296 <211> LENGTH: 27 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H40 (PN) <400> SEQUENCE: 296
ggatgtccac cttgtcccgc gaattct 27 <210> SEQ ID NO 297
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker - Linker H40 (AA) <400>
SEQUENCE: 297 Gly Cys Pro Pro Cys Pro Ala Asn Ser 1 5 <210>
SEQ ID NO 298 <400> SEQUENCE: 298 000 <210> SEQ ID NO
299 <211> LENGTH: 9 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker - Linker H41 <400>
SEQUENCE: 299 Gly Cys Pro Pro Cys Pro Ala Asn Ser 1 5 <210>
SEQ ID NO 300 <400> SEQUENCE: 300 000 <210> SEQ ID NO
301 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker - Linker H42(AA)
<400> SEQUENCE: 301 Gly Cys Pro Pro Cys Pro Asn Ser 1 5
<210> SEQ ID NO 302 <400> SEQUENCE: 302 000 <210>
SEQ ID NO 303 <400> SEQUENCE: 303 000 <210> SEQ ID NO
304 <211> LENGTH: 36 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker polynucleotide - Linker
H44 (PN) <400> SEQUENCE: 304 ggaggagcta gttgtccacc ttgtcccggg
aattct 36 <210> SEQ ID NO 305 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H44 (AA) <400> SEQUENCE: 305 Gly Gly Ala Ser
Cys Pro Pro Cys Pro Gly Asn Ser 1 5 10 <210> SEQ ID NO 306
<211> LENGTH: 36 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H45
(PN) <400> SEQUENCE: 306 ggaggagcca gttgtccacc ttgtgccggg
aattct 36 <210> SEQ ID NO 307 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H45 (AA) <400> SEQUENCE: 307 Gly Gly Ala Ser
Cys Pro Pro Cys Ala Gly Asn Ser 1 5 10 <210> SEQ ID NO 308
<211> LENGTH: 33 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H46
<400> SEQUENCE: 308 ggaggagcca gttgtccacc ttgtgcgaat tct 33
<210> SEQ ID NO 309 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H46
<400> SEQUENCE: 309 Gly Gly Ala Ser Cys Pro Pro Cys Ala Asn
Ser 1 5 10 <210> SEQ ID NO 310 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H47 <400> SEQUENCE: 310 Leu Ser Val Lys Ala
Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 1 5 10 15 <210> SEQ
ID NO 311 <211> LENGTH: 12 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker - Linker H48 <400>
SEQUENCE: 311 Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 1 5
10 <210> SEQ ID NO 312 <400> SEQUENCE: 312 000
<210> SEQ ID NO 313 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H50
<400> SEQUENCE: 313 Leu Ser Val Leu Ala Asn Phe Ser Gln Pro
Glu Ile Gly Asn Ser 1 5 10 15 <210> SEQ ID NO 314 <211>
LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H51 <400> SEQUENCE: 314 Leu
Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 1 5 10 15
<210> SEQ ID NO 315 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide - Scorpion region
linker <400> SEQUENCE: 315 Ser Gln Pro Glu Ile Val Pro Ile
Ser Asn Ser 1 5 10 <210> SEQ ID NO 316 <211> LENGTH: 16
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H53 <400> SEQUENCE: 316 Ser Gln Pro Glu Ile
Val Pro Ile Ser Cys Pro Pro Cys Pro Asn Ser 1 5 10 15 <210>
SEQ ID NO 317 <211> LENGTH: 19 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H54
<400> SEQUENCE: 317 Ser Val Leu Ala Asn Phe Ser Gln Pro Glu
Ile Ser Cys Pro Pro Cys 1 5 10 15 Pro Asn Ser <210> SEQ ID NO
318 <211> LENGTH: 15 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker - Linker H55 <400>
SEQUENCE: 318 Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala
Asn Ser 1 5 10 15 <210> SEQ ID NO 319 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H56 <400> SEQUENCE: 319 Gln Met Asn Ser Glu
Leu Ser Val Leu Ala Asn Ser 1 5 10 <210> SEQ ID NO 320
<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker - Linker H57 <400>
SEQUENCE: 320 Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 1 5 10
<210> SEQ ID NO 321 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H58
<400> SEQUENCE: 321 Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp
Thr Cys Pro Asn Ser 1 5 10 15 <210> SEQ ID NO 322 <211>
LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H59 <400> SEQUENCE: 322 Lys
Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 1 5 10 15
<210> SEQ ID NO 323 <211> LENGTH: 14 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H60
<400> SEQUENCE: 323 Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe
Ser Met Asn Ser 1 5 10 <210> SEQ ID NO 324 <211>
LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H61 <400> SEQUENCE: 324 Glu
Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 1 5 10
15 Asp Cys Pro Asn Ser 20 <210> SEQ ID NO 325 <211>
LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H62 <400> SEQUENCE: 325 Gln
Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 1 5 10
15 His Cys Pro Asn Ser 20 <210> SEQ ID NO 326 <211>
LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H63 <400> SEQUENCE: 326 Asn
Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 1 5 10
15 Cys Asn Ser <210> SEQ ID NO 327 <211> LENGTH: 21
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker <400> SEQUENCE: 327 Gln Arg His Asn Asn Ser Ser Leu
Asn Thr Arg Thr Gln Lys Ala Arg 1 5 10 15 His Cys Pro Asn Ser 20
<210> SEQ ID NO 328 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H65
<400> SEQUENCE: 328 Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile
Glu Leu Gln Lys Asp Ser 1 5 10 15 Asp Cys Pro Asn Ser 20
<210> SEQ ID NO 329 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H66
<400> SEQUENCE: 329 Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile
Glu Leu Gln Lys Asp Ser 1 5 10 15 Asp Cys Pro Asn Ser 20
<210> SEQ ID NO 330 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H67
<400> SEQUENCE: 330 Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile
Glu Leu Gln Lys Asp Ser 1 5 10 15 Asp Cys Pro Asn Ser 20
<210> SEQ ID NO 331 <211> LENGTH: 118 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H68
<400> SEQUENCE: 331 Arg Thr Arg Tyr Leu Gln Val Ser Gln Gln
Leu Gln Gln Thr Asn Arg 1 5 10 15 Val Leu Glu Val Thr Asn Ser Ser
Leu Arg Gln Gln Leu Arg Leu Lys 20 25 30 Ile Thr Gln Leu Gly Gln
Ser Ala Glu Asp Leu Gln Gly Ser Arg Arg 35 40 45 Glu Leu Ala Gln
Ser Gln Glu Ala Leu Gln Val Glu Gln Arg Ala His 50 55 60 Gln Ala
Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg Gln Lys 65 70 75 80
Thr Lys Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu 85
90 95 Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr
Cys 100 105 110 Gly Ser Ala Asp Thr Cys 115 <210> SEQ ID NO
332 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: anti-CD-20 VL CDR1 <400> SEQUENCE: 332 Arg
Ala Ser Ser Ser Val Ser Tyr Ile His 1 5 10 <210> SEQ ID NO
333 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: anti-CD-20 VL CDR1 <400> SEQUENCE: 333 Arg
Ala Ser Ser Ser Val Ser Tyr Ile Val 1 5 10 <210> SEQ ID NO
334 <211> LENGTH: 9 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: anti-CD-20 VL CDR3 <400> SEQUENCE: 334 Gln
Gln Trp Ser Phe Asn Pro Pro Thr 1 5 <210> SEQ ID NO 335
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: anti-CD-20 VL CDR3 <400> SEQUENCE: 335 Gln Gln
Tyr Ser Phe Asn Pro Pro Thr 1 5 <210> SEQ ID NO 336
<211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: anti-CD-20 VH CDR2 <400> SEQUENCE: 336 Ala Ile
Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 1 5 10 15
Gly <210> SEQ ID NO 337 <211> LENGTH: 17 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: anti-CD-20 VH CDR2
<400> SEQUENCE: 337 Ala Ile Tyr Pro Gly Asn Gly Glu Thr Ser
Tyr Asn Gln Lys Phe Lys 1 5 10 15 Gly <210> SEQ ID NO 338
<211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: anti-CD20 VH CDR3 <400> SEQUENCE: 338 Ser Val
Tyr Tyr Ser Asn Tyr Trp Tyr Phe Asp Leu 1 5 10 <210> SEQ ID
NO 339 <211> LENGTH: 12 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: anti-CD20 VH CDR3 <400> SEQUENCE: 339 Ser
Val Tyr Tyr Gly Gly Tyr Trp Tyr Phe Asp Leu 1 5 10 <210> SEQ
ID NO 340 <211> LENGTH: 12 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: anti-CD20 VH CDR3 <400> SEQUENCE: 340 Ser
Tyr Tyr Ser Asn Ser Asp Trp Tyr Phe Asp Leu 1 5 10 <210> SEQ
ID NO 341 <211> LENGTH: 12 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: anti-CD20 VH CDR3 <400> SEQUENCE: 341 Ser
Tyr Tyr Ser Gly Gly Asp Trp Tyr Phe Asp Leu 1 5 10 <210> SEQ
ID NO 342 <211> LENGTH: 12 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: anti-CD20 VH CDR3 <400> SEQUENCE: 342 Ser
Tyr Lys Ser Asn Ser Tyr Trp Tyr Phe Asp Leu 1 5 10 <210> SEQ
ID NO 343 <211> LENGTH: 12 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: anti-CD20 VH CDR3 <400> SEQUENCE: 343 Ser
Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Leu 1 5 10 <210> SEQ
ID NO 344 <211> LENGTH: 12 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: anti-CD-20 VH CDR3 <400> SEQUENCE: 344 Ser
Tyr Lys Ser Asn Ser Asp Trp Tyr Phe Asp Leu 1 5 10 <210> SEQ
ID NO 345 <211> LENGTH: 12 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: anti-CD20 VH CDR3 <400> SEQUENCE: 345 Ser
Tyr Lys Ser Gly Gly Asp Trp Tyr Phe Asp Leu 1 5 10 <210> SEQ
ID NO 346 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion linker core (2H7) sequence <400>
SEQUENCE: 346 Gly Cys Pro Pro Cys Pro Asn Ser 1 5 <210> SEQ
ID NO 347 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Extension sequence <400> SEQUENCE: 347 Ala
Pro Glu Leu 1 <210> SEQ ID NO 348 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Extension
sequence <400> SEQUENCE: 348 Ala Pro Glu Leu Gly Gly Gly Gly
Ser 1 5 <210> SEQ ID NO 349 <211> LENGTH: 14
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Extension
sequence <400> SEQUENCE: 349 Ala Pro Glu Leu Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser 1 5 10 <210> SEQ ID NO 350
<211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Extension sequence <400> SEQUENCE: 350 Ala Pro
Glu Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 1 5 10 15
Gly Gly Ser <210> SEQ ID NO 351 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Extended
scorpion linker <400> SEQUENCE: 351 Gly Cys Pro Pro Cys Pro
Asn Ser Ala Pro Glu Leu 1 5 10 <210> SEQ ID NO 352
<211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Extended scorpion linker <400> SEQUENCE: 352 Gly
Cys Pro Pro Cys Pro Asn Ser Ala Pro Glu Leu Gly Gly Gly Gly 1 5 10
15 Ser <210> SEQ ID NO 353 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Extended scorpion linker
<400> SEQUENCE: 353 Gly Cys Pro Pro Cys Pro Asn Ser Ala Pro
Glu Leu Gly Gly Gly Gly 1 5 10 15 Ser Gly Gly Gly Gly Ser 20
<210> SEQ ID NO 354 <211> LENGTH: 27 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Extended scorpion linker <400>
SEQUENCE: 354 Gly Cys Pro Pro Cys Pro Asn Ser Ala Pro Glu Leu Gly
Gly Gly Gly 1 5 10 15 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
20 25 <210> SEQ ID NO 355 <400> SEQUENCE: 355 000
<210> SEQ ID NO 356 <400> SEQUENCE: 356 000 <210>
SEQ ID NO 357 <400> SEQUENCE: 357 000 <210> SEQ ID NO
358 <400> SEQUENCE: 358 000 <210> SEQ ID NO 359
<400> SEQUENCE: 359 000 <210> SEQ ID NO 360 <400>
SEQUENCE: 360 000 <210> SEQ ID NO 361 <400> SEQUENCE:
361 000 <210> SEQ ID NO 362 <400> SEQUENCE: 362 000
<210> SEQ ID NO 363 <400> SEQUENCE: 363 000 <210>
SEQ ID NO 364 <400> SEQUENCE: 364 000 <210> SEQ ID NO
365 <400> SEQUENCE: 365 000 <210> SEQ ID NO 366
<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: partial CH3 sequence <400> SEQUENCE: 366 Gln Lys
Ser Leu Ser Leu Ser Pro Gly Lys 1 5 10 <210> SEQ ID NO 367
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Partial CH3 sequence <400> SEQUENCE: 367 Gln Lys
Ser Leu Ser Leu Ser Pro Gly 1 5 <210> SEQ ID NO 368
<211> LENGTH: 1 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Partial CH3 sequence <400> SEQUENCE: 368 Gln 1
<210> SEQ ID NO 369 <211> LENGTH: 3 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Partial CH3 sequence <400>
SEQUENCE: 369 Gln Lys Ser 1 <210> SEQ ID NO 370 <211>
LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Partial CH3 sequence <400> SEQUENCE: 370 Gln Lys Ser Leu Ser
Leu 1 5 <210> SEQ ID NO 371 <211> LENGTH: 5 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Partial CH3 sequence
<400> SEQUENCE: 371 Gln Lys Ser Leu Ser 1 5 <210> SEQ
ID NO 372 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion linker <400> SEQUENCE: 372 Gly
Cys Pro Pro Cys 1 5 <210> SEQ ID NO 373 <211> LENGTH:
12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
<400> SEQUENCE: 373 Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe
Ser Met 1 5 10 <210> SEQ ID NO 374 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
<400> SEQUENCE: 374 Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr
Cys 1 5 10 <210> SEQ ID NO 375 <211> LENGTH: 18
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
<400> SEQUENCE: 375 Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile
Glu Leu Gln Lys Asp Ser 1 5 10 15 Asp Cys <210> SEQ ID NO 376
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker <400> SEQUENCE: 376 Gln Arg His
Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 1 5 10 15 His
Cys <210> SEQ ID NO 377 <211> LENGTH: 17 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Scorpion linker <400>
SEQUENCE: 377 Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr
Glu Ser Tyr 1 5 10 15 Cys <210> SEQ ID NO 378 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
anti-CD20 VL CDR1 (TRU-015) <400> SEQUENCE: 378 Arg Ala Ser
Ser Ser Val Ser Tyr Met His 1 5 10 <210> SEQ ID NO 379
<211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: anti-CD20 VH CDR3 (TRU-015) <400> SEQUENCE: 379
Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val 1 5 10
<210> SEQ ID NO 380 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 380
Cys Pro Pro Cys 1 <210> SEQ ID NO 381 <211> LENGTH: 18
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: linker peptide
<400> SEQUENCE: 381 Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 1 5 10 15 Ser Gly <210> SEQ ID NO 382
<211> LENGTH: 36 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: linker peptide <400> SEQUENCE: 382 Asn Tyr Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 1 5 10 15 Ser
Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 20 25
30 Gly Gly Ser Gly 35 <210> SEQ ID NO 383 <211> LENGTH:
6 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: linker peptide
<400> SEQUENCE: 383 Gly Gly Gly Gly Ser Gly 1 5 <210>
SEQ ID NO 384 <211> LENGTH: 8 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: linker peptide <400> SEQUENCE:
384 Asn Tyr Gly Gly Gly Gly Ser Gly 1 5 <210> SEQ ID NO 385
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: linker peptide <400> SEQUENCE: 385 Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 <210> SEQ ID NO 386
<211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: linker peptide <400> SEQUENCE: 386 Asn Tyr Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 <210> SEQ ID
NO 387 <211> LENGTH: 16 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: linker peptide <400> SEQUENCE: 387 Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15
<210> SEQ ID NO 388 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: linker peptide <400> SEQUENCE:
388 Gly Cys Pro Pro Cys Pro 1 5 <210> SEQ ID NO 389
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: linker peptide <400> SEQUENCE: 389 Asn Ser Gln
Val Gln 1 5 <210> SEQ ID NO 390 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: linker peptide
<400> SEQUENCE: 390 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 1 5 10 15 <210> SEQ ID NO 391 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
peptide sequence typically preceeding CDR-H2 <400> SEQUENCE:
391 Leu Glu Trp Ile Gly 1 5 <210> SEQ ID NO 392 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
peptide sequence typically following CDR-H2 <220> FEATURE:
<221> NAME/KEY: MISC_FEATURE <222> LOCATION: (2)..(2)
<223> OTHER INFORMATION: Xaa may be Arg or Leu <220>
FEATURE: <221> NAME/KEY: MISC_FEATURE <222> LOCATION:
(7)..(7) <223> OTHER INFORMATION: Xaa may be Ala or Thr
<400> SEQUENCE: 392 Lys Xaa Ile Val Phe Thr Xaa Ser Ile Ala 1
5 10 <210> SEQ ID NO 393 <211> LENGTH: 4 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: peptide sequence typically
following CDR-L3 <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (3)..(3) <223> OTHER
INFORMATION: Xaa can be any naturally occurring amino acid
<400> SEQUENCE: 393 Phe Gly Xaa Gly 1 <210> SEQ ID NO
394 <211> LENGTH: 15 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: linker peptide <400> SEQUENCE: 394 Asp Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1 5 10 15
<210> SEQ ID NO 395 <211> LENGTH: 20 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: linker peptide <400> SEQUENCE:
395 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
1 5 10 15 Gly Gly Gly Ser 20 <210> SEQ ID NO 396 <211>
LENGTH: 4 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: heavy
chain variant end peptide sequence <400> SEQUENCE: 396 Val
Thr Val Ser 1 <210> SEQ ID NO 397 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: heavy chain
variant end peptide sequence <400> SEQUENCE: 397 Val Thr Val
Ser Ser 1 5 <210> SEQ ID NO 398 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Unknown <220>
FEATURE: <223> OTHER INFORMATION: CD20 motif recognized by
2H7 antibody <400> SEQUENCE: 398 Ala Asn Pro Ser 1
<210> SEQ ID NO 399 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scorpion binding domain <400>
SEQUENCE: 399 Ser Tyr Ile Val 1 <210> SEQ ID NO 400
<211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scorpion binding domain <400> SEQUENCE: 400 Ser
Tyr Ile His 1 <210> SEQ ID NO 401 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scorpion
binding domain <400> SEQUENCE: 401 Asn Ser Tyr Trp 1
<210> SEQ ID NO 402 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scorpion binding domain <400>
SEQUENCE: 402 Cys Gln Gln Trp 1 <210> SEQ ID NO 403
<211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: partial scorpion linker sequence <400> SEQUENCE:
403 Cys Cys Cys Pro 1 <210> SEQ ID NO 404 <211> LENGTH:
4 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: partial
scorpion linker sequence <400> SEQUENCE: 404 Cys Ser Cys Ser
1 <210> SEQ ID NO 405 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: partial scorpion linker sequence
<400> SEQUENCE: 405 Ser Cys Cys Ser 1 <210> SEQ ID NO
406 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: partial scorpion linker sequence <400>
SEQUENCE: 406 Ser Cys Cys Pro 1 <210> SEQ ID NO 407
<211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: partial scorpion linker sequence <400> SEQUENCE:
407 Cys Ser Ser Ser 1 <210> SEQ ID NO 408 <211> LENGTH:
5 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: linker peptide
<400> SEQUENCE: 408 Gly Gly Gly Gly Ser 1 5 <210> SEQ
ID NO 409 <211> LENGTH: 17 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: linker peptide <400> SEQUENCE: 409 Glu Pro
Lys Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 1 5 10 15
Ser <210> SEQ ID NO 410 <211> LENGTH: 17 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: linker peptide <400>
SEQUENCE: 410 Glu Pro Lys Ser Thr Asp Lys Thr His Thr Ser Pro Pro
Ser Pro Asn 1 5 10 15 Ser <210> SEQ ID NO 411 <211>
LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: linker
peptide <400> SEQUENCE: 411 Leu Asn Val Ser Glu Arg Pro Phe
Pro Pro His Ile Gln Asn Ser 1 5 10 15 <210> SEQ ID NO 412
<211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: linker peptide <400> SEQUENCE: 412 Gly Gly Gly
Ala Ser Cys Pro Pro Cys Pro Gly Asn Ser 1 5 10 <210> SEQ ID
NO 413 <211> LENGTH: 13 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: linker peptide <400> SEQUENCE: 413 Gly Gly
Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 1 5 10 <210> SEQ
ID NO 414 <211> LENGTH: 12 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: linker peptide <400> SEQUENCE: 414 Gly Gly
Gly Ala Ser Cys Pro Pro Cys Ala Asn Ser 1 5 10 <210> SEQ ID
NO 415 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: linker peptide <400> SEQUENCE: 415 Ala Asp
Phe Leu Thr Pro Ser Ile Gly Asn Ser 1 5 10 <210> SEQ ID NO
416 <211> LENGTH: 20 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: linker peptide <400> SEQUENCE: 416 Glu Pro
Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 1 5 10 15
Asp Cys Asn Ser 20 <210> SEQ ID NO 417 <211> LENGTH: 20
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: linker peptide
<400> SEQUENCE: 417 Gln Arg His Asn Asn Ser Ser Leu Asn Thr
Arg Thr Gln Lys Ala Arg 1 5 10 15 His Cys Asn Ser 20
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 417
<210> SEQ ID NO 1 <211> LENGTH: 795 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polynucleotide - anti-CD20
(2H7) LH (DNA) <400> SEQUENCE: 1 atggattttc aagtgcagat
tttcagcttc ctgctaatca gtgcttcagt cataatgtcc 60 agaggacaaa
ttgttctctc ccagtctcca gcaatcctgt ctgcatctcc aggggagaag 120
gtcacaatga cttgcagggc cagctcaagt gtaagttaca tgcactggta ccagcagaag
180 ccaggatcct cccccaaacc ctggatttat gccccatcca acctggcttc
tggagtccct 240 gctcgcttca gtggcagtgg gtctgggacc tcttactctc
tcacaatcag cagagtggag 300 gctgaagatg ctgccactta ttactgccag
cagtggagtt ttaacccacc cacgttcggt 360 gctgggacca agctggagct
gaaagatggc ggtggctcgg gcggtggtgg atctggagga 420 ggtgggagct
ctcaggctta tctacagcag tctggggctg agtcggtgag gcctggggcc 480
tcagtgaaga tgtcctgcaa ggcttctggc tacacattta ccagttacaa tatgcactgg
540 gtaaagcaga cacctagaca gggcctggaa tggattggag ctatttatcc
aggaaatggt 600 gatacttcct acaatcagaa gttcaagggc aaggccacac
tgactgtaga caaatcctcc 660 agcacagcct acatgcagct cagcagcctg
acatctgaag actctgcggt ctatttctgt 720 gcaagagtgg tgtactatag
taactcttac tggtacttcg atgtctgggg cacagggacc 780 acggtcaccg tctct
795 <210> SEQ ID NO 2 <211> LENGTH: 265 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polypeptide -
anti-CD20 (2H7) LH (AA) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(22) <223> OTHER
INFORMATION: Leader <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (23)..(128) <223> OTHER
INFORMATION: VL <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (129)..(144) <223> OTHER
INFORMATION: Linker <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (145)..(265) <223> OTHER
INFORMATION: VH <400> SEQUENCE: 2 Met Asp Phe Gln Val Gln Ile
Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg
Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser
Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55
60 Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro
65 70 75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu
Thr Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr
Cys Gln Gln Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly
Thr Lys Leu Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln
Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys
Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn
Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185
190 Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
195 200 205 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr
Ala Tyr 210 215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala
Val Tyr Phe Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser
Tyr Trp Tyr Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr
Val Ser 260 265 <210> SEQ ID NO 3 <211> LENGTH: 813
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polynucleotide - anti-CD28 (2e12) LH (DNA) <400> SEQUENCE: 3
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcc
60 agaggagtcg acattgtgct cacccaatct ccagcttctt tggctgtgtc
tctaggtcag 120 agagccacca tctcctgcag agccagtgaa agtgttgaat
attatgtcac aagtttaatg 180 cagtggtacc aacagaaacc aggacagcca
cccaaactcc tcatctctgc tgctagcaac 240 gtagaatctg gggtccctgc
caggtttagt ggcagtgggt ctgggacaga ctttagcctc 300 aacatccatc
ctgtggagga ggatgatatt gcaatgtatt tctgtcagca aagtaggaag 360
gttccatgga cgttcggtgg aggcaccaag ctggaaatca aacggggtgg cggtggatcc
420 ggcggaggtg ggtcgggtgg cggcggatct caggtgcagc tgaaggagtc
aggacctggc 480 ctggtggcgc cctcacagag cctgtccatc acatgcaccg
tctcagggtt ctcattaacc 540 ggctatggtg taaactgggt tcgccagcct
ccaggaaagg gtctggagtg gctgggaatg 600 atatggggtg atggaagcac
agactataat tcagctctca aatccagact atcgatcacc 660 aaggacaact
ccaagagcca agttttctta aaaatgaaca gtctgcaaac tgatgacaca 720
gccagatact actgtgcccg agatggttat agtaactttc attactatgt tatggactac
780 tggggtcaag gaacctcagt caccgtctcc tct 813 <210> SEQ ID NO
4 <211> LENGTH: 271 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic polypeptide - anti-CD28 (2e12) LH (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(23) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (24)..(135) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(136)..(150) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(151)..(271) <223> OTHER INFORMATION: VH <400>
SEQUENCE: 4 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser
Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Val Asp Ile Val Leu Thr
Gln Ser Pro Ala 20 25 30 Ser Leu Ala Val Ser Leu Gly Gln Arg Ala
Thr Ile Ser Cys Arg Ala 35 40 45 Ser Glu Ser Val Glu Tyr Tyr Val
Thr Ser Leu Met Gln Trp Tyr Gln 50 55 60 Gln Lys Pro Gly Gln Pro
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 65 70 75 80 Val Glu Ser Gly
Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 85 90 95 Asp Phe
Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met 100 105 110
Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly 115
120 125 Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly
Gly 130 135 140 Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser
Gly Pro Gly 145 150 155 160 Leu Val Ala Pro Ser Gln Ser Leu Ser Ile
Thr Cys Thr Val Ser Gly 165 170 175 Phe Ser Leu Thr Gly Tyr Gly Val
Asn Trp Val Arg Gln Pro Pro Gly 180 185 190 Lys Gly Leu Glu Trp Leu
Gly Met Ile Trp Gly Asp Gly Ser Thr Asp 195 200 205 Tyr Asn Ser Ala
Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser 210 215 220 Lys Ser
Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 225 230 235
240 Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr
245 250 255 Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser
Ser 260 265 270 <210> SEQ ID NO 5 <211> LENGTH: 828
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polynucleotide - anti-CD28 (2e12) HL
(DNA) <400> SEQUENCE: 5 atggattttc aagtgcagat tttcagcttc
ctgctaatca gtgcttcagt cataatgtcc 60 agaggagtcc aggtgcagct
gaaggagtca ggacctggcc tggtggcgcc ctcacagagc 120 ctgtccatca
catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt 180
cgccagcctc caggaaaggg tctggagtgg ctgggaatga tatggggtga tggaagcaca
240 gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc
caagagccaa 300 gttttcttaa aaatgaacag tctgcaaact gatgacacag
ccagatacta ctgtgcccga 360 gatggttata gtaactttca ttactatgtt
atggactact ggggtcaagg aacctcagtc 420 accgtctcct ctgggggtgg
aggctctggt ggcggtggat ccggcggagg tgggtcgggt 480 ggcggcggat
ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt 540
cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta
600 atgcagtggt accaacagaa accaggacag ccacccaaac tcctcatctc
tgctgctagc 660 aacgtagaat ctggggtccc tgccaggttt agtggcagtg
ggtctgggac agactttagc 720 ctcaacatcc atcctgtgga ggaggatgat
attgcaatgt atttctgtca gcaaagtagg 780 aaggttccat ggacgttcgg
tggaggcacc aagctggaaa tcaaacgt 828 <210> SEQ ID NO 6
<211> LENGTH: 276 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide - anti-CD28 (2e12) HL (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(23) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (24)..(144) <223> OTHER INFORMATION: VH <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(164) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(165)..(276) <223> OTHER INFORMATION: VL <400>
SEQUENCE: 6 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser
Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Val Gln Val Gln Leu Lys
Glu Ser Gly Pro 20 25 30 Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
Ile Thr Cys Thr Val Ser 35 40 45 Gly Phe Ser Leu Thr Gly Tyr Gly
Val Asn Trp Val Arg Gln Pro Pro 50 55 60 Gly Lys Gly Leu Glu Trp
Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 65 70 75 80 Asp Tyr Asn Ser
Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 85 90 95 Ser Lys
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 100 105 110
Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr 115
120 125 Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser
Ser 130 135 140 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly 145 150 155 160 Gly Gly Gly Ser Asp Ile Val Leu Thr Gln
Ser Pro Ala Ser Leu Ala 165 170 175 Val Ser Leu Gly Gln Arg Ala Thr
Ile Ser Cys Arg Ala Ser Glu Ser 180 185 190 Val Glu Tyr Tyr Val Thr
Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 195 200 205 Gly Gln Pro Pro
Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 210 215 220 Gly Val
Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 225 230 235
240 Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys
245 250 255 Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu 260 265 270 Glu Ile Lys Arg 275 <210> SEQ ID NO 7
<211> LENGTH: 30 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - Heavy Chain GSP1 <400>
SEQUENCE: 7 aggtgctgga ggggacagtc actgagctgc 30 <210> SEQ ID
NO 8 <211> LENGTH: 28 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - Nested Heavy Chain
<400> SEQUENCE: 8 gtcacwgtca ctgrctcagg gaartagc 28
<210> SEQ ID NO 9 <211> LENGTH: 33 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - Light Chain GSP1
<400> SEQUENCE: 9 gggtgctgct catgctgtag gtgctgtctt tgc 33
<210> SEQ ID NO 10 <211> LENGTH: 32 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - Nested Light
Chain <400> SEQUENCE: 10 caagaagcac acgactgagg cacctccaga tg
32 <210> SEQ ID NO 11 <211> LENGTH: 36 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer - Race
Abridged Anchor Primer <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (24)..(25) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (29)..(30) <223>
OTHER INFORMATION: n is a, c, g, or t <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (34)..(35)
<223> OTHER INFORMATION: n is a, c, g, or t <400>
SEQUENCE: 11 ggccacgcgt cgactagtac gggnngggnn gggnng 36 <210>
SEQ ID NO 12 <211> LENGTH: 20 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - T7 primer
<400> SEQUENCE: 12 gtaatacgac tcactatagg 20 <210> SEQ
ID NO 13 <211> LENGTH: 18 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - M13 reverse primer
<400> SEQUENCE: 13 caggaaacag ctatgacc 18 <210> SEQ ID
NO 14 <211> LENGTH: 15 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 14 Glu Pro Lys Ser Cys
Asp Lys Thr His Thr Cys Pro Pro Cys Pro 1 5 10 15 <210> SEQ
ID NO 15 <211> LENGTH: 46 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 15 gcgataaagc
ttgccgccat ggaagcacca gcgcagcttc tcttcc 46 <210> SEQ ID NO 16
<211> LENGTH: 50 <212> TYPE: DNA <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 16 accagcgcag cttctcttcc
tcctgctact ctggctccca gataccaccg 50 <210> SEQ ID NO 17
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 17 ggctcccaga taccaccggt
caaattgttc tctcccagtc tccag 45
<210> SEQ ID NO 18 <211> LENGTH: 35 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 2H7VHNheF
<400> SEQUENCE: 18 gcgatagcta gccaggctta tctacagcag tctgg 35
<210> SEQ ID NO 19 <211> LENGTH: 43 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - G4SNheR
<400> SEQUENCE: 19 gcgatagcta gccccacctc ctccagatcc
accaccgccc gag 43 <210> SEQ ID NO 20 <211> LENGTH: 35
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - 015VHXhoR <400> SEQUENCE: 20 gcgtactcga ggagacggtg
accgtggtcc ctgtg 35 <210> SEQ ID NO 21 <211> LENGTH: 37
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - G1HC-Xho <400> SEQUENCE: 21 gcagtctcga gcgagcccaa
atcttgtgac aaaactc 37 <210> SEQ ID NO 22 <211> LENGTH:
37 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - G1H-S-Xho <400> SEQUENCE: 22 gcagtctcga gcgagcccaa
atcttctgac aaaactc 37 <210> SEQ ID NO 23 <211> LENGTH:
36 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - CH3REcoR1 <400> SEQUENCE: 23 gcgtgagaat tcttacccgg
agacagggag aggctc 36 <210> SEQ ID NO 24 <211> LENGTH:
32 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - G1 XBZ-R <400> SEQUENCE: 24 gcgacgtcta gagtcattta
cccggagaca gg 32 <210> SEQ ID NO 25 <211> LENGTH: 54
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - G4SLinkR1-S <400> SEQUENCE: 25 aattatggtg gcggtggctc
gggcggtggt ggatctggag gaggtgggag tggg 54 <210> SEQ ID NO 26
<211> LENGTH: 54 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - G4SLinkR1-AS <400> SEQUENCE:
26 aattcccact cccacctcct ccagatccac caccgcccga gccaccgcca ccat 54
<210> SEQ ID NO 27 <211> LENGTH: 36 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 2E12VLXbaR
<400> SEQUENCE: 27 gcgtgtctag attaacgttt gatttccagc ttggtg 36
<210> SEQ ID NO 28 <211> LENGTH: 35 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 2E12VLR1F
<400> SEQUENCE: 28 gcgatgaatt ctgacattgt gctcacccaa tctcc 35
<210> SEQ ID NO 29 <211> LENGTH: 34 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 2E12VHR1F
<400> SEQUENCE: 29 gcgatgaatt ctcaggtgca gctgaaggag tcag 34
<210> SEQ ID NO 30 <211> LENGTH: 37 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 2E12VHXbaR
<400> SEQUENCE: 30 gcgagtctag attaagagga gacggtgact gaggttc
37 <210> SEQ ID NO 31 <211> LENGTH: 27 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
2e12VHdXbaF1 <400> SEQUENCE: 31 gggtctggag tggctgggaa tgatatg
27 <210> SEQ ID NO 32 <211> LENGTH: 28 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
2e12VHdXbaR1 <400> SEQUENCE: 32 attcccagcc actccagacc
ctttcctg 28 <210> SEQ ID NO 33 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - IgBsrG1F <400> SEQUENCE: 33 gagaaccaca ggtgtacacc
ctg 23 <210> SEQ ID NO 34 <211> LENGTH: 25 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer - IgBsrG1R
<400> SEQUENCE: 34 gcagggtgta cacctgtggt tctcg 25 <210>
SEQ ID NO 35 <211> LENGTH: 17 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - M13R <400>
SEQUENCE: 35 caggaaacag ctatgac 17 <210> SEQ ID NO 36
<211> LENGTH: 18 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - M13F <400> SEQUENCE: 36
gtaaaacgac ggccagtg 18 <210> SEQ ID NO 37 <211> LENGTH:
20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - T7 <400> SEQUENCE: 37 gtaatacgac tcactatagg 20
<210> SEQ ID NO 38 <211> LENGTH: 17 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - pD18F-17
<400> SEQUENCE: 38
aactagagaa cccactg 17 <210> SEQ ID NO 39 <211> LENGTH:
20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - pD18F-20 <400> SEQUENCE: 39 gctaactaga gaacccactg 20
<210> SEQ ID NO 40 <211> LENGTH: 18 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - pD18F-1
<400> SEQUENCE: 40 atacgactca ctataggg 18 <210> SEQ ID
NO 41 <211> LENGTH: 19 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - pD18R-s <400> SEQUENCE:
41 gctctagcat ttaggtgac 19 <210> SEQ ID NO 42 <211>
LENGTH: 18 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - CH3seqF1 <400> SEQUENCE: 42 catgaggctc
tgcacaac 18 <210> SEQ ID NO 43 <211> LENGTH: 18
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - CH3seqF2 <400> SEQUENCE: 43 cctctacagc aagctcac 18
<210> SEQ ID NO 44 <211> LENGTH: 19 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - CH3seqR1
<400> SEQUENCE: 44 ggttcttggt cagctcatc 19 <210> SEQ ID
NO 45 <211> LENGTH: 18 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - CH3seqR2 <400>
SEQUENCE: 45 gtgagcttgc tgtagagg 18 <210> SEQ ID NO 46
<211> LENGTH: 51 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - L1-11R <400> SEQUENCE: 46
gcgatagaat tcccagatcc accaccgccc gagccaccgc caccataatt c 51
<210> SEQ ID NO 47 <211> LENGTH: 36 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - L1-6R <400>
SEQUENCE: 47 gcgatagaat tcccagagcc accgccacca taattc 36 <210>
SEQ ID NO 48 <211> LENGTH: 45 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - L3R <400>
SEQUENCE: 48 gcgtatgaat tccccgagcc accgccaccc ttacccggag acagg 45
<210> SEQ ID NO 49 <211> LENGTH: 49 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - L4R <400>
SEQUENCE: 49 gcgtatgaat tcccagatcc accaccgccc gagccaccgc cacccttac
49 <210> SEQ ID NO 50 <211> LENGTH: 44 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer - L5R
<400> SEQUENCE: 50 gcgtatgaat tcccgctgcc tcctccccca
gatccaccac cgcc 44 <210> SEQ ID NO 51 <211> LENGTH: 23
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - IgBsrG1F <400> SEQUENCE: 51 gagaaccaca ggtgtacacc
ctg 23 <210> SEQ ID NO 52 <211> LENGTH: 50 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer - L-CPPCPR
<400> SEQUENCE: 52 gcgatagaat tcggacaagg tggacacccc
ttacccggag acagggagag 50 <210> SEQ ID NO 53 <211>
LENGTH: 41 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - G281LH-NheR <400> SEQUENCE: 53 actgctgcag
ctggaccgcg ctagctccgc cgccacccga c 41 <210> SEQ ID NO 54
<211> LENGTH: 40 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - G281LH-NheF <400> SEQUENCE:
54 ggcggagcta gcgcggtcca gctgcagcag tctggacctg 40 <210> SEQ
ID NO 55 <211> LENGTH: 37 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - G281-LH-LPinF <400>
SEQUENCE: 55 gcgatcaccg gtgacatcca gatgactcag tctccag 37
<210> SEQ ID NO 56 <211> LENGTH: 37 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - G281-LH-HXhoR
<400> SEQUENCE: 56 gcgatactcg aggagacggt gactgaggtt ccttgac
37 <210> SEQ ID NO 57 <211> LENGTH: 38 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
G281-LH-LEcoF <400> SEQUENCE: 57 gcgatcgaat tcagacatcc
agatgactca gtctccag 38 <210> SEQ ID NO 58 <211> LENGTH:
43 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - G281-LH-HXbaR <400> SEQUENCE: 58 gcgattctag
attaggaaga gacggtgact gaggttcctt gac 43 <210> SEQ ID NO 59
<211> LENGTH: 37 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - G281-HL-HF <400> SEQUENCE:
59
gcgataaccg gtgcggtcca gctgcagcag tctggac 37 <210> SEQ ID NO
60 <211> LENGTH: 52 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - G281-HL-HR3 <400>
SEQUENCE: 60 gacccaccac cgcccgagcc accgccacca gaagagacgg tgactgaggt
tc 52 <210> SEQ ID NO 61 <211> LENGTH: 49 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
G281-HL-HR2 <400> SEQUENCE: 61 actcccgcct cctcctgatc
cgccgccacc cgacccacca ccgcccgag 49 <210> SEQ ID NO 62
<211> LENGTH: 42 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - G281-HL-HNheR <400> SEQUENCE:
62 gagtcatctg gatgtcgcta gcactcccgc ctcctcctga tc 42 <210>
SEQ ID NO 63 <211> LENGTH: 45 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - G281-HL-LNheF
<400> SEQUENCE: 63 atcaggagga ggcgggagtg ctagcgacat
ccagatgact cagtc 45 <210> SEQ ID NO 64 <211> LENGTH: 37
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - G281-HL-LXhoR <400> SEQUENCE: 64 gcgatactcg
agcctttgat ctccagttcg gtgcctc 37 <210> SEQ ID NO 65
<211> LENGTH: 42 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - G281-HL-LXhoR <400> SEQUENCE:
65 gcgatatcta gactcaacct ttgatctcca gttcggtgcc tc 42 <210>
SEQ ID NO 66 <211> LENGTH: 37 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - G281-HL-EcoF
<400> SEQUENCE: 66 gcgatagaat tcgcggtcca gctgcagcag tctggac
37 <210> SEQ ID NO 67 <211> LENGTH: 40 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
194-LH-LF1 <400> SEQUENCE: 67 gcgtatgaac cggtgacatc
cagatgacac agactacatc 40 <210> SEQ ID NO 68 <211>
LENGTH: 50 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-LF2 <400> SEQUENCE: 68 atccagatga
cacagactac atcctccctg tctgcctctc tgggagacag 50 <210> SEQ ID
NO 69 <211> LENGTH: 52 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-LF3 <400> SEQUENCE:
69 gtctgcctct ctgggagaca gagtcaccat cagttgcagg gcaagtcagg ac 52
<210> SEQ ID NO 70 <211> LENGTH: 50 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-LF4
<400> SEQUENCE: 70 gttgcagggc aagtcaggac attcgcaatt
atttaaactg gtatcagcag 50 <210> SEQ ID NO 71 <211>
LENGTH: 50 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-LF5 <400> SEQUENCE: 71 atttaaactg
gtatcagcag aaaccagatg gaactgttaa actcctgatc 50 <210> SEQ ID
NO 72 <211> LENGTH: 50 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-LF6 <400> SEQUENCE:
72 gaactgttaa actcctgatc tactacacat caagattaca ctcaggagtc 50
<210> SEQ ID NO 73 <211> LENGTH: 52 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-LF7
<400> SEQUENCE: 73 caagattaca ctcaggagtc ccatcaaggt
tcagtggcag tgggtctgga ac 52 <210> SEQ ID NO 74 <211>
LENGTH: 52 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-LR7 <400> SEQUENCE: 74 caggttggca
atggtgagag aataatctgt tccagaccca ctgccactga ac 52 <210> SEQ
ID NO 75 <211> LENGTH: 50 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-LR6 <400> SEQUENCE:
75 gcaaaagtaa gtggcaatat cttctggttg caggttggca atggtgagag 50
<210> SEQ ID NO 76 <211> LENGTH: 51 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-LR5
<400> SEQUENCE: 76 gaacgtccac ggaagcgtat taccctgttg
gcaaaagtaa gtggcaatat c 51 <210> SEQ ID NO 77 <211>
LENGTH: 52 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-LR4 <400> SEQUENCE: 77 cgtttggtta
ccagtttggt gcctccaccg aacgtccacg gaagcgtatt ac 52 <210> SEQ
ID NO 78 <211> LENGTH: 46 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-LR3 <400> SEQUENCE:
78 accaccgccc gagccaccgc caccccgttt ggttaccagt ttggtg 46
<210> SEQ ID NO 79 <211> LENGTH: 50 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-LR2
<400> SEQUENCE: 79 gctagcgctc ccacctcctc cagatccacc
accgcccgag ccaccgccac 50 <210> SEQ ID NO 80 <211>
LENGTH: 42 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-LH-LR1
<400> SEQUENCE: 80 gttgcagctg gacctcgcta gcgctcccac
ctcctccaga tc 42 <210> SEQ ID NO 81 <211> LENGTH: 54
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - 194-LH-HF1 <400> SEQUENCE: 81 gatctggagg aggtgggagc
gctagcgagg tccagctgca acagtctgga cctg 54 <210> SEQ ID NO 82
<211> LENGTH: 50 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - 194-HF2 <400> SEQUENCE: 82
agctgcaaca gtctggacct gaactggtga agcctggagc ttcaatgaag 50
<210> SEQ ID NO 83 <211> LENGTH: 50 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-HF3
<400> SEQUENCE: 83 agcctggagc ttcaatgaag atttcctgca
aggcctctgg ttactcattc 50 <210> SEQ ID NO 84 <211>
LENGTH: 53 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-HF4 <400> SEQUENCE: 84 gcaaggcctc
tggttactca ttcactggct acatcgtgaa ctggctgaag cag 53 <210> SEQ
ID NO 85 <211> LENGTH: 52 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-HF5 <400> SEQUENCE:
85 atcgtgaact ggctgaagca gagccatgga aagaaccttg agtggattgg ac 52
<210> SEQ ID NO 86 <211> LENGTH: 52 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-HF6
<400> SEQUENCE: 86 gaaccttgag tggattggac ttattaatcc
atacaaaggt cttactacct ac 52 <210> SEQ ID NO 87 <211>
LENGTH: 52 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-HR6 <400> SEQUENCE: 87 aatgtggcct
tgcccttgaa tttctggttg taggtagtaa gacctttgta tg 52 <210> SEQ
ID NO 88 <211> LENGTH: 52 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-HR5 <400> SEQUENCE:
88 catgtaggct gtgctggatg acttgtctac agttaatgtg gccttgccct tg 52
<210> SEQ ID NO 89 <211> LENGTH: 55 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-HR4
<400> SEQUENCE: 89 actgcagagt cttcagatgt cagactgagg
agctccatgt aggctgtgct ggatg 55 <210> SEQ ID NO 90 <211>
LENGTH: 52 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-HR3 <400> SEQUENCE: 90 accatagtac
ccagatcttg cacagtaata gactgcagag tcttcagatg tc 52 <210> SEQ
ID NO 91 <211> LENGTH: 52 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-HR2 <400> SEQUENCE:
91 gcgccccaga catcgaagta ccagtccgag tcaccatagt acccagatct tg 52
<210> SEQ ID NO 92 <211> LENGTH: 52 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-LH-HR1
<400> SEQUENCE: 92 gcgaatactc gaggagacgg tgaccgtggt
ccctgcgccc cagacatcga ag 52 <210> SEQ ID NO 93 <211>
LENGTH: 42 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-HL-HF1 <400> SEQUENCE: 93 gcgtatgaac
cggtgaggtc cagctgcaac agtctggacc tg 42 <210> SEQ ID NO 94
<211> LENGTH: 55 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - 194-HL-HR1 <400> SEQUENCE: 94
accgccacca gaggagacgg tgaccgtggt ccctgcgccc cagacatcga agtac 55
<210> SEQ ID NO 95 <211> LENGTH: 52 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-HL-HR0
<400> SEQUENCE: 95 acctcctcca gatccaccac cgcccgagcc
accgccacca gaggagacgg tg 52 <210> SEQ ID NO 96 <211>
LENGTH: 49 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-HL-LF1 <400> SEQUENCE: 96 gcgggggagg
tggcagtgct agcgacatcc agatgacaca gactacatc 49 <210> SEQ ID NO
97 <211> LENGTH: 34 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-HL-LR3Xho <400>
SEQUENCE: 97 gcgaatactc gagcgtttgg ttaccagttt ggtg 34 <210>
SEQ ID NO 98 <211> LENGTH: 37 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - 194-HL-LR3Xba
<400> SEQUENCE: 98 gcgatatcta gattaccgtt tggttaccag tttggtg
37 <210> SEQ ID NO 99 <211> LENGTH: 43 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic primer -
194-HL-HF1R1 <400> SEQUENCE: 99 gcgtatgaga attcagaggt
ccagctgcaa cagtctggac ctg 43 <210> SEQ ID NO 100 <211>
LENGTH: 41 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - 194-LH-LF1R1 <400> SEQUENCE: 100
gcgtatgaga attctgacat ccagatgaca cagactacat c 41 <210> SEQ ID
NO 101 <211> LENGTH: 54 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Synthetic primer - 194-LH-HR1Xba
<400> SEQUENCE: 101 gcgtatctag attaggagac ggtgaccgtg
gtccctgcgc cccagacatc gaag 54 <210> SEQ ID NO 102 <211>
LENGTH: 725 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polynucleotide - G28-1 VLVH (DNA) <400> SEQUENCE:
102 accggtgaca tccagatgac tcagtctcca gcctccctat ctgcatctgt
gggagagact 60 gtcaccatca catgtcgaac aagtgaaaat gtttacagtt
atttggcttg gtatcagcag 120 aaacagggaa aatctcctca gctcctggtc
tcttttgcaa aaaccttagc agaaggtgtg 180 ccatcaaggt tcagtggcag
tggatcaggc acacagtttt ctctgaagat cagcagcctg 240 cagcctgaag
attctggaag ttatttctgt caacatcatt ccgataatcc gtggacgttc 300
ggtggaggca ccgaactgga gatcaaaggt ggcggtggct cgggcggtgg tgggtcgggt
360 ggcggcggat ctgctagcgc agtccagctg cagcagtctg gacctgagct
ggaaaagcct 420 ggcgcttcag tgaagatttc ctgcaaggct tctggttact
cattcactgg ctacaatatg 480 aactgggtga agcagaataa tggaaagagc
cttgagtgga ttggaaatat tgatccttat 540 tatggtggta ctacctacaa
ccggaagttc aagggcaagg ccacattgac tgtagacaaa 600 tcctccagca
cagcctacat gcagctcaag agtctgacat ctgaggactc tgcagtctat 660
tactgtgcaa gatcggtcgg ccctatggac tactggggtc aaggaacctc agtcaccgtc
720 tcgag 725 <210> SEQ ID NO 103 <211> LENGTH: 239
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polypeptide - G-28-1 VLVH (AA) <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1)..(107) <223>
OTHER INFORMATION: VL <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (108)..(124) <223> OTHER
INFORMATION: Linker <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (125)..(239) <223> OTHER
INFORMATION: VH <400> SEQUENCE: 103 Asp Ile Gln Met Thr Gln
Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Glu Thr Val Thr
Ile Thr Cys Arg Thr Ser Glu Asn Val Tyr Ser Tyr 20 25 30 Leu Ala
Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 35 40 45
Ser Phe Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Ser Ser Leu Gln
Pro 65 70 75 80 Glu Asp Ser Gly Ser Tyr Phe Cys Gln His His Ser Asp
Asn Pro Trp 85 90 95 Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys
Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ala Ser Ala Val Gln Leu 115 120 125 Gln Gln Ser Gly Pro Glu Leu
Glu Lys Pro Gly Ala Ser Val Lys Ile 130 135 140 Ser Cys Lys Ala Ser
Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn Trp 145 150 155 160 Val Lys
Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile Gly Asn Ile Asp 165 170 175
Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe Lys Gly Lys Ala 180
185 190 Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu
Lys 195 200 205 Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala
Arg Ser Val 210 215 220 Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser
Val Thr Val Ser 225 230 235 <210> SEQ ID NO 104 <211>
LENGTH: 767 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic polynucleotide - G28-1 VHVL (DNA) <400> SEQUENCE:
104 accggtgagg tccagctgca acagtctgga cctgaactgg tgaagcctgg
agcttcaatg 60 aagatttcct gcaaggcctc tggttactca ttcactggct
acatcgtgaa ctggctgaag 120 cagagccatg gaaagaacct tgagtggatt
ggacttatta atccatacaa aggtcttact 180 acctacaacc agaaattcaa
gggcaaggcc acattaactg tagacaagtc atccagcaca 240 gcctacatgg
agctcctcag tctgacatct gaagactctg cagtctatta ctgtgcaaga 300
tctgggtact atggtgactc ggactggtac ttcgatgtct ggggcgcagg gaccacggtc
360 accgtctcct ctggtggcgg tggctcgggc ggtggtggat ctggaggagg
tgggagcggg 420 ggaggtggca gtgctagcga catccagatg acacagacta
catcctccct gtctgcctct 480 ctgggagaca gagtcaccat cagttgcagg
gcaagtcagg acattcgcaa ttatttaaac 540 tggtatcagc agaaaccaga
tggaactgtt aaactcctga tctactacac atcaagatta 600 cactcaggag
tcccatcaag gttcagtggc agtgggtctg gaacagatta ttctctcacc 660
attgccaacc tgcaaccaga agatattgcc acttactttt gccaacaggg taatacgctt
720 ccgtggacgt tcggtggagg caccaaactg gtaaccaaac gctcgag 767
<210> SEQ ID NO 105 <211> LENGTH: 253 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide - G28-1 VHVL
(AA) <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(121) <223> OTHER INFORMATION: VH
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (122)..(144) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (145)..(253) <223> OTHER INFORMATION: VL
<400> SEQUENCE: 105 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu
Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Met Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ser Phe Thr Gly Tyr 20 25 30 Ile Val Asn Trp Leu Lys
Gln Ser His Gly Lys Asn Leu Glu Trp Ile 35 40 45 Gly Leu Ile Asn
Pro Tyr Lys Gly Leu Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val
Trp 100 105 110 Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ala Ser 130 135 140 Asp Ile Gln Met Thr Gln Thr Thr Ser
Ser Leu Ser Ala Ser Leu Gly 145 150 155 160 Asp Arg Val Thr Ile Ser
Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 165 170 175 Leu Asn Trp Tyr
Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 180 185 190 Tyr Tyr
Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 195 200 205
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro 210
215 220 Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro
Trp 225 230 235 240 Thr Phe Gly Gly Gly Thr Lys Leu Val Thr Lys Arg
Ser 245 250 <210> SEQ ID NO 106 <211> LENGTH: 749
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
polynucleotide - G19-4 VLVH (DNA) <400> SEQUENCE: 106
accggtgaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga
60 gtcaccatca gttgcagggc aagtcaggac attcgcaatt atttaaactg
gtatcagcag 120 aaaccagatg gaactgttaa actcctgatc tactacacat
caagattaca ctcaggagtc 180 ccatcaaggt tcagtggcag tgggtctgga
acagattatt ctctcaccat tgccaacctg 240 caaccagaag atattgccac
ttacttttgc caacagggta atacgcttcc gtggacgttc 300 ggtggaggca
ccaaactggt aaccaaacgg ggtggcggtg gctcgggcgg tggtggatct 360
ggaggaggtg ggagcgctag cgaggtccag ctgcaacagt ctggacctga actggtgaag
420 cctggagctt caatgaagat ttcctgcaag gcctctggtt actcattcac
tggctacatc 480 gtgaactggc tgaagcagag ccatggaaag aaccttgagt
ggattggact tattaatcca 540 tacaaaggtc ttactaccta caaccagaaa
ttcaagggca aggccacatt aactgtagac 600 aagtcatcca gcacagccta
catggagctc ctcagtctga catctgaaga ctctgcagtc 660 tattactgtg
caagatctgg gtactatggt gactcggact ggtacttcga tgtctggggc 720
gcagggacca cggtcaccgt ctcctcgag 749 <210> SEQ ID NO 107
<211> LENGTH: 247 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polypeptide - G-19-4 VLVH (AA) <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1)..(108) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(109)..(125) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(126)..(247) <223> OTHER INFORMATION: VH <400>
SEQUENCE: 107 Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala
Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
Asp Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Asp
Gly Thr Val Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His
Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr
Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro 65 70 75 80 Glu Asp Ile
Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr
Phe Gly Gly Gly Thr Lys Leu Val Thr Lys Arg Gly Gly Gly Gly 100 105
110 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Glu Val Gln
115 120 125 Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser
Met Lys 130 135 140 Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly
Tyr Ile Val Asn 145 150 155 160 Trp Leu Lys Gln Ser His Gly Lys Asn
Leu Glu Trp Ile Gly Leu Ile 165 170 175 Asn Pro Tyr Lys Gly Leu Thr
Thr Tyr Asn Gln Lys Phe Lys Gly Lys 180 185 190 Ala Thr Leu Thr Val
Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu 195 200 205 Leu Ser Leu
Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser 210 215 220 Gly
Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly 225 230
235 240 Thr Thr Val Thr Val Ser Ser 245 <210> SEQ ID NO 108
<211> LENGTH: 752 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic polynucleotide - G19-4 VHVL (DNA)
<400> SEQUENCE: 108 accggtgagg tccagctgca acagtctgga
cctgaactgg tgaagcctgg agcttcaatg 60 aagatttcct gcaaggcctc
tggttactca ttcactggct acatcgtgaa ctggctgaag 120 cagagccatg
gaaagaacct tgagtggatt ggacttatta atccatacaa aggtcttact 180
acctacaacc agaaattcaa gggcaaggcc acattaactg tagacaagtc atccagcaca
240 gcctacatgg agctcctcag tctgacatct gaagactctg cagtctatta
ctgtgcaaga 300 tctgggtact atggtgactc ggactggtac ttcgatgtct
ggggcgcagg gaccacggtc 360 accgtctcct ctggtggcgg tggctcgggc
ggtggtggat ctggaggagg tgggagcgct 420 agcgacatcc agatgacaca
gactacatcc tccctgtctg cctctctggg agacagagtc 480 accatcagtt
gcagggcaag tcaggacatt cgcaattatt taaactggta tcagcagaaa 540
ccagatggaa ctgttaaact cctgatctac tacacatcaa gattacactc aggagtccca
600 tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattgc
caacctgcaa 660 ccagaagata ttgccactta cttttgccaa cagggtaata
cgcttccgtg gacgttcggt 720 ggaggcacca aactggtaac caaacgctcg ag 752
<210> SEQ ID NO 109 <211> LENGTH: 248 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic polypeptide - G19-4 VHVL
(AA) <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(122) <223> OTHER INFORMATION: VH
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (123)..(139) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (140)..(248) <223> OTHER INFORMATION: VL
<400> SEQUENCE: 109 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu
Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Met Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ser Phe Thr Gly Tyr 20 25 30 Ile Val Asn Trp Leu Lys
Gln Ser His Gly Lys Asn Leu Glu Trp Ile 35 40 45 Gly Leu Ile Asn
Pro Tyr Lys Gly Leu Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val
Trp 100 105 110 Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser
Asp Ile Gln Met Thr 130 135 140 Gln Thr Thr Ser Ser Leu Ser Ala Ser
Leu Gly Asp Arg Val Thr Ile 145 150 155 160 Ser Cys Arg Ala Ser Gln
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln 165 170 175 Gln Lys Pro Asp
Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 180 185 190 Leu His
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205
Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro Glu Asp Ile Ala Thr 210
215 220 Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gly
Gly 225 230 235 240 Thr Lys Leu Val Thr Lys Arg Ser 245 <210>
SEQ ID NO 110 <211> LENGTH: 45 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - ssc(s)-hIgG1
(DNA) <400> SEQUENCE: 110 gagcccaaat cttctgacaa aactcacaca
tctccaccgt gctca 45 <210> SEQ ID NO 111 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide - ssc(s)-hIgG1 (AA) <400> SEQUENCE: 111 Glu Pro Lys
Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 1 5 10 15
<210> SEQ ID NO 112 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - scc(s)-hIgG1
(DNA) <400> SEQUENCE: 112 gagcccaaat cttctgacaa aactcacaca
tgtccaccgt gctca 45 <210> SEQ ID NO 113 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide - scc(s)-hIgG1 (AA) <400> SEQUENCE: 113 Glu Pro Lys
Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 1 5 10 15
<210> SEQ ID NO 114 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - css(s)-hIgG1
(DNA) <400> SEQUENCE: 114 gagcccaaat cttgtgacaa aactcacaca
tctccaccga gctca 45 <210> SEQ ID NO 115 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
peptide - css(s)-hIgG1 (AA) <400> SEQUENCE: 115
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 1 5 10
15 <210> SEQ ID NO 116 <211> LENGTH: 45 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Synthetic polynucleotide -
scs(s)-hIgG1 (DNA) <400> SEQUENCE: 116 gagcccaaat cttgtgacaa
aactcacaca tgtccaccga gctca 45 <210> SEQ ID NO 117
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic peptide - scs(s)-hIgG1 (AA) <400>
SEQUENCE: 117 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
Ser Ser 1 5 10 15 <210> SEQ ID NO 118 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer <400> SEQUENCE: 118 gagcccaaat cttgtgacaa aactcacaca
tgtccaccgt gctca 45 <210> SEQ ID NO 119 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
region <400> SEQUENCE: 119 Glu Pro Lys Ser Cys Asp Lys Thr
His Thr Cys Pro Pro Cys Ser 1 5 10 15 <210> SEQ ID NO 120
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer <400> SEQUENCE: 120 gagcccaaat
cttgtgacaa aactcacaca tgtccaccgt gccca 45 <210> SEQ ID NO 121
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region <400> SEQUENCE: 121 Glu
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 1 5 10 15
<210> SEQ ID NO 122 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer <400>
SEQUENCE: 122 gagcccaaat cttctgacaa aactcacaca tctccaccga gccca 45
<210> SEQ ID NO 123 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion linker region <400>
SEQUENCE: 123 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro
Ser Pro 1 5 10 15 <210> SEQ ID NO 124 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - csc(p)-hIgG1 (DNA) <400> SEQUENCE: 124 gagcccaaat
cttgtgacaa aactcacaca tctccaccgt gccca 45 <210> SEQ ID NO 125
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region - csc(p)-hIgG1 (AA) <400>
SEQUENCE: 125 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro
Cys Pro 1 5 10 15 <210> SEQ ID NO 126 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - ssc(p)-hIgG1 (DNA) <400> SEQUENCE: 126 gagcccaaat
cttctgacaa aactcacaca tctccaccgt gccca 45 <210> SEQ ID NO 127
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region - ssc(p)-hIgG1 (AA) <400>
SEQUENCE: 127 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro
Cys Pro 1 5 10 15 <210> SEQ ID NO 128 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - scc(p)-hIgG1 (DNA) <400> SEQUENCE: 128 gagcccaaat
cttctgacaa aactcacaca tgtccaccgt gccca 45 <210> SEQ ID NO 129
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region - scc(p)-hIgG1 (AA) <400>
SEQUENCE: 129 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
Cys Pro 1 5 10 15 <210> SEQ ID NO 130 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - css(p)-hIgG1 (DNA) <400> SEQUENCE: 130 gagcccaaat
cttgtgacaa aactcacaca tctccaccga gccca 45 <210> SEQ ID NO 131
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region - css(p)-hIgG1 (AA) <400>
SEQUENCE: 131 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro
Ser Pro 1 5 10 15 <210> SEQ ID NO 132 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - ssc(p)-hIgG1 (DNA) <400> SEQUENCE: 132 gagcccaaat
cttgtgacaa aactcacaca tgtccaccga gccca 45 <210> SEQ ID NO 133
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker region - ssc(p)-hIgG1 (DNA)
<400> SEQUENCE: 133 Glu Pro Lys Ser Ser Asp Lys Thr His Thr
Cys Pro Pro Ser Pro 1 5 10 15 <210> SEQ ID NO 134 <211>
LENGTH: 18 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - ssc(p) (DNA) <400> SEQUENCE: 134
agttgtccac cgtgccca 18 <210> SEQ ID NO 135 <211>
LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion linker region <400> SEQUENCE: 135
Ser Cys Pro Pro Cys Pro 1 5 <210> SEQ ID NO 136 <211>
LENGTH: 7 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer <400> SEQUENCE: 136 tgatcag 7 <210>
SEQ ID NO 137 <211> LENGTH: 2 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 137 Asp Gln 1 <210> SEQ ID NO 138 <211>
LENGTH: 7 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer <400> SEQUENCE: 138 ctcgagt 7 <210>
SEQ ID NO 139 <211> LENGTH: 2 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide <400>
SEQUENCE: 139 Ser Ser 1 <210> SEQ ID NO 140 <211>
LENGTH: 654 <212> TYPE: DNA <213> ORGANISM: Homo
sapiens <400> SEQUENCE: 140 gcacctgaac tcctgggtgg accgtcagtc
ttcctcttcc ccccaaaacc caaggacacc 60 ctcatgatct cccggacccc
tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac 120 cctgaggtca
agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag 180
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac
240 caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc
cctcccagcc 300 cccatcgaga aaacaatctc caaagccaaa gggcagcccc
gagaaccaca ggtgtacacc 360 ctgcccccat cccgggatga gctgaccaag
aaccaggtca gcctgacctg cctggtcaaa 420 ggcttctatc ccagcgacat
cgccgtggag tgggagagca atgggcagcc ggagaacaac 480 tacaagacca
cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc 540
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag
600 gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga 654
<210> SEQ ID NO 141 <211> LENGTH: 217 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 141
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5
10 15 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
Val 20 25 30 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr 35 40 45 Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg Glu Glu 50 55 60 Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90 95 Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 115 120 125 Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 130 135
140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145 150 155 160 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu 165 170 175 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val 180 185 190 Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Pro
Gly Lys 210 215 <210> SEQ ID NO 142 <211> LENGTH: 654
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 142 gcacctgaac tcctgggtgg atcgtcagtc
ttcctcttcc ccccaaaacc caaggacacc 60 ctcatgatct cccggacccc
tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac 120 cctgaggtca
agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag 180
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac
240 caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc
cctcccagcc 300 cccatcgaga aaacaatctc caaagccaaa gggcagcccc
gagaaccaca ggtgtacacc 360 ctgcccccat cccgggatga gctgaccaag
aaccaggtca gcctgacctg cctggtcaaa 420 ggcttctatc ccagcgacat
cgccgtggag tgggagagca atgggcagcc ggagaacaac 480 tacaagacca
cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc 540
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag
600 gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga 654
<210> SEQ ID NO 143 <211> LENGTH: 217 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 143
Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys 1 5
10 15 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
Val 20 25 30 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr 35 40 45 Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg Glu Glu 50 55 60 Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90 95 Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 115 120 125 Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 130 135
140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145 150 155 160 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu 165 170 175 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val 180 185 190 Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Pro
Gly Lys 210 215 <210> SEQ ID NO 144 <211> LENGTH: 654
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 144 gcacctgaac tcctgggtgg accgtcagtc
ttcctcttcc ccccaaaacc caaggacacc 60 ctcatgatct cccggacccc
tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac 120 cctgaggtca
agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag 180
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac
240 caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc
cctcccagcc 300 tccatcgaga aaacaatctc caaagccaaa gggcagcccc
gagaaccaca ggtgtacacc 360 ctgcccccat cccgggatga gctgaccaag
aaccaggtca gcctgacctg cctggtcaaa 420 ggcttctatc ccagcgacat
cgccgtggag tgggagagca atgggcagcc ggagaacaac 480 tacaagacca
cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc 540
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag
600 gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga 654
<210> SEQ ID NO 145 <211> LENGTH: 217 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
145
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5
10 15 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
Val 20 25 30 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr 35 40 45 Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg Glu Glu 50 55 60 Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90 95 Ala Leu Pro Ala Ser
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 115 120 125 Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 130 135
140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145 150 155 160 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu 165 170 175 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val 180 185 190 Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Pro
Gly Lys 210 215 <210> SEQ ID NO 146 <211> LENGTH: 654
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 146 gcacctgaac tcctgggtgg atcgtcagtc
ttcctcttcc ccccaaaacc caaggacacc 60 ctcatgatct cccggacccc
tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac 120 cctgaggtca
agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag 180
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac
240 caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc
cctcccagcc 300 tccatcgaga aaacaatctc caaagccaaa gggcagcccc
gagaaccaca ggtgtacacc 360 ctgcccccat cccgggatga gctgaccaag
aaccaggtca gcctgacctg cctggtcaaa 420 ggcttctatc ccagcgacat
cgccgtggag tgggagagca atgggcagcc ggagaacaac 480 tacaagacca
cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc 540
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag
600 gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atga 654
<210> SEQ ID NO 147 <211> LENGTH: 217 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 147
Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys 1 5
10 15 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
Val 20 25 30 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr 35 40 45 Val Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg Glu Glu 50 55 60 Gln Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90 95 Ala Leu Pro Ala Ser
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 115 120 125 Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 130 135
140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145 150 155 160 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu 165 170 175 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val 180 185 190 Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Pro
Gly Lys 210 215 <210> SEQ ID NO 148 <211> LENGTH: 60
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Synthetic
primer - STD1 (DNA) <400> SEQUENCE: 148 aattatggtg gcggtggctc
gggcggtggt ggatctggag gaggtgggag tgggaattct 60 <210> SEQ ID
NO 149 <211> LENGTH: 20 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion linker region - STD1 (AA) <400>
SEQUENCE: 149 Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly 1 5 10 15 Ser Gly Asn Ser 20 <210> SEQ ID NO 150
<211> LENGTH: 114 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - STD2 (DNA) <400> SEQUENCE:
150 aattatggtg gcggtggctc gggcggtggt ggatctggag gaggtgggag
tgggaattat 60 ggtggcggtg gctcgggcgg tggtggatct ggaggaggtg
ggagtgggaa ttct 114 <210> SEQ ID NO 151 <211> LENGTH:
38 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
region - STD2 (AA) <400> SEQUENCE: 151 Asn Tyr Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 1 5 10 15 Ser Gly Asn
Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 20 25 30 Gly
Gly Ser Gly Asn Ser 35 <210> SEQ ID NO 152 <211>
LENGTH: 6 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - Linker H1 (PN) <400> SEQUENCE: 152 aattct
6 <210> SEQ ID NO 153 <211> LENGTH: 2 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion linker region - Linker H1
(AA) <400> SEQUENCE: 153 Asn Ser 1 <210> SEQ ID NO 154
<211> LENGTH: 24 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - Linker H2 (PN) <400>
SEQUENCE: 154 ggtggcggtg gctcggggaa ttct 24 <210> SEQ ID NO
155 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion linker region - Linker H2 (AA)
<400> SEQUENCE: 155 Gly Gly Gly Gly Ser Gly Asn Ser 1 5
<210> SEQ ID NO 156 <211> LENGTH: 30 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - Linker H3 (PN)
<400> SEQUENCE: 156 aattatggtg gcggtggctc tgggaattct 30
<210> SEQ ID NO 157 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
region - Linker H3 (AA) <400> SEQUENCE: 157 Asn Tyr Gly Gly
Gly Gly Ser Gly Asn Ser 1 5 10 <210> SEQ ID NO 158
<211> LENGTH: 39 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - Linker H4 (PN) <400>
SEQUENCE: 158 ggtggcggtg gctcgggcgg tggtggatct gggaattct 39
<210> SEQ ID NO 159 <211> LENGTH: 13 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion linker region - Linker H4
(AA) <400> SEQUENCE: 159 Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Asn Ser 1 5 10 <210> SEQ ID NO 160 <211>
LENGTH: 45 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Synthetic primer - Linker H5 (PN) <400> SEQUENCE: 160
aattatggtg gcggtggctc gggcggtggt ggatctggga attct 45 <210>
SEQ ID NO 161 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion linker region - Linker H5
(AA) <400> SEQUENCE: 161 Asn Tyr Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Asn Ser 1 5 10 15 <210> SEQ ID NO 162
<211> LENGTH: 54 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - Linker H6 (PN) <400>
SEQUENCE: 162 ggtggcggtg gctcgggcgg tggtggatct gggggaggag
gcagcgggaa ttct 54 <210> SEQ ID NO 163 <211> LENGTH: 18
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
region - Linker H6 (AA) <400> SEQUENCE: 163 Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Asn Ser
<210> SEQ ID NO 164 <211> LENGTH: 24 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - Linker H7 (PN)
<400> SEQUENCE: 164 gggtgtccac cttgtccgaa ttct 24 <210>
SEQ ID NO 165 <211> LENGTH: 8 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion linker region - Linker H7
(AA) <400> SEQUENCE: 165 Gly Cys Pro Pro Cys Pro Asn Ser 1 5
<210> SEQ ID NO 166 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic primer - Linker(G4S)3
<400> SEQUENCE: 166 ggtggcggtg gatccggcgg aggtgggtcg
ggtggcggcg gatct 45 <210> SEQ ID NO 167 <211> LENGTH:
12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
region - Linker(G3S)3 <400> SEQUENCE: 167 Gly Gly Gly Ser Gly
Gly Gly Ser Gly Gly Gly Ser 1 5 10 <210> SEQ ID NO 168
<211> LENGTH: 60 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Synthetic primer - Linker(G4S)4 <400> SEQUENCE:
168 ggtggcggtg gctcgggcgg tggtggatct ggaggaggtg ggagcggggg
aggtggcagt 60 <210> SEQ ID NO 169 <211> LENGTH: 17
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
region - Linker(G3S)4 <400> SEQUENCE: 169 Gly Gly Gly Ser Gly
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 1 5 10 15 Ser
<210> SEQ ID NO 170 <211> LENGTH: 2337 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: 2H7sssIgG1-STD1-2e12HL
(DNA) <400> SEQUENCE: 170 aagcttgccg ccatggattt tcaagtgcag
attttcagct tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca
aattgttctc tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga
aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180
taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct
240 tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc
tctcacaatc 300 agcagagtgg aggctgaaga tgctgccact tattactgcc
agcagtggag ttttaaccca 360 cccacgttcg gtgctgggac caagctggag
ctgaaagatg gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag
ctctcaggct tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg
cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac 540
aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat
600 ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac
actgactgta 660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc
tgacatctga agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat
agtaactctt actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac
cgtctctgat caggagccca aatcttctga caaaactcac 840 acatccccac
cgagctcagc acctgaactc ctggggggac cgtcagtctt cctcttcccc 900
ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg
960 gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg
cgtggaggtg 1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca
gcacgtaccg tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg
aatggcaagg agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc
catcgagaaa acaatctcca aagccaaagg gcagccccga 1200 gaaccacagg
tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260
ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat
1320 gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga
cggctccttc 1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc
agcaggggaa cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac
cactacacgc agaagagcct ctccctgtct 1500 ccgggtaaga attatggtgg
cggtggctcg ggcggtggtg gatctggagg aggtgggagt 1560 gggaattctc
aggtgcagct gaaggagtca ggacctggcc tggtggcgcc ctcacagagc 1620
ctgtccatca catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt
1680 cgccagcctc caggaaaggg tctggagtgg ctgggaatga tatggggtga
tggaagcaca 1740 gactataatt cagctctcaa atccagacta tcgatcacca
aggacaactc caagagccaa 1800 gttttcttaa aaatgaacag tctgcaaact
gatgacacag ccagatacta ctgtgctcga 1860 gatggttata gtaactttca
ttactatgtt atggactact ggggtcaagg aacctcagtc 1920 accgtctcct
ctgggggtgg aggctctggt ggcggtggat ccggcggagg tgggtcgggt 1980
ggcggcggat ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt
2040 cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt
cacaagttta 2100 atgcagtggt accaacagaa accaggacag ccacccaaac
tcctcatctc tgctgctagc 2160 aacgtagaat ctggggtccc tgccaggttt
agtggcagtg ggtctgggac agactttagc 2220 ctcaacatcc atcctgtgga
ggaggatgat attgcaatgt atttctgtca gcaaagtagg 2280 aaggttccat
ggacgttcgg tggaggcacc aagctggaaa tcaaacgtta atctaga 2337
<210> SEQ ID NO 171 <211> LENGTH: 772 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sssIgG1-STD1-2e12HL (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(22) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (23)..(128) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(281) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(519) <223> OTHER INFORMATION: EFD-BD2 linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (520)..(640) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (641)..(660) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (661)..(772) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 171 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Ser Gln Val
Gln Leu Lys Glu Ser Gly Pro 515 520 525 Gly Leu Val Ala Pro Ser Gln
Ser Leu Ser Ile Thr Cys Thr Val Ser 530 535 540 Gly Phe Ser Leu Thr
Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 545 550 555 560 Gly Lys
Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 565 570 575
Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn 580
585 590 Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp
Asp 595 600 605 Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn
Phe His Tyr 610 615 620 Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser
Val Thr Val Ser Ser 625 630 635 640 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly 645 650 655 Gly Gly Gly Ser Asp Ile
Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 660 665 670 Val Ser Leu Gly
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 675 680 685 Val Glu
Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 690 695 700
Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 705
710 715 720 Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Ser 725 730 735 Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala
Met Tyr Phe Cys 740 745 750 Gln Gln Ser Arg Lys Val Pro Trp Thr Phe
Gly Gly Gly Thr Lys Leu 755 760 765 Glu Ile Lys Arg 770 <210>
SEQ ID NO 172 <211> LENGTH: 772 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sssIgG1(P238S/P331S)-STD1-2e12HL
(w/2e12 leader) (AA) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(22) <223> OTHER
INFORMATION: Leader <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (23)..(128) <223> OTHER
INFORMATION: VL <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (129)..(144) <223> OTHER
INFORMATION: Linker <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (145)..(265) <223> OTHER
INFORMATION: VH <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (268)..(282) <223> OTHER
INFORMATION: Hinge <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (500)..(519) <223> OTHER
INFORMATION: EFD-BD2 linker <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (520)..(640)
<223> OTHER INFORMATION: VH2 <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (641)..(660)
<223> OTHER INFORMATION: Linker2 <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(661)..(772) <223> OTHER INFORMATION: VL2 <400>
SEQUENCE: 172 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile
Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser
Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly Glu Lys Val
Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser Tyr Met His
Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60
Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65
70 75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu
Thr Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr
Cys Gln Gln Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly
Thr Lys Leu Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln
Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys
Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn
Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185
190 Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
195 200 205 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr
Ala Tyr 210 215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala
Val Tyr Phe Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser
Tyr Trp Tyr Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr
Val Ser Asp Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr
Ser Pro Pro Ser Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310
315 320 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
Val 325 330 335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
Ser Thr Tyr 340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln
Asp Trp Leu Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys Ala Leu Pro Ala Ser Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435
440 445 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
Val 450 455 460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
Ser Val Met 465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn
Ser Gln Val Gln Leu Lys Glu Ser Gly Pro 515 520 525 Gly Leu Val Ala
Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 530 535 540 Gly Phe
Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 545 550 555
560 Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr
565 570 575 Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys
Asp Asn 580 585 590 Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu
Gln Thr Asp Asp 595 600 605 Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly
Tyr Ser Asn Phe His Tyr 610 615 620 Tyr Val Met Asp Tyr Trp Gly Gln
Gly Thr Ser Val Thr Val Ser Ser 625 630 635 640 Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 645 650 655 Gly Gly Gly
Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 660 665 670 Val
Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 675 680
685 Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro
690 695 700 Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val
Glu Ser 705 710 715 720 Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser
Gly Thr Asp Phe Ser 725 730 735 Leu Asn Ile His Pro Val Glu Glu Asp
Asp Ile Ala Met Tyr Phe Cys 740 745 750 Gln Gln Ser Arg Lys Val Pro
Trp Thr Phe Gly Gly Gly Thr Lys Leu 755 760 765 Glu Ile Lys Arg 770
<210> SEQ ID NO 173 <211> LENGTH: 2322 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: 2H7sssIgG1-STD1-2e12LH
(DNA) <400> SEQUENCE: 173 aagcttgccg ccatggattt tcaagtgcag
attttcagct tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca
aattgttctc tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga
aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180
taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct
240 tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc
tctcacaatc 300 agcagagtgg aggctgaaga tgctgccact tattactgcc
agcagtggag ttttaaccca 360 cccacgttcg gtgctgggac caagctggag
ctgaaagatg gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag
ctctcaggct tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg
cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac 540
aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat
600 ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac
actgactgta 660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc
tgacatctga agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat
agtaactctt actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac
cgtctctgat caggagccca aatcttctga caaaactcac 840 acatccccac
cgagcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc 900
ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg
960 gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg
cgtggaggtg 1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca
gcacgtaccg tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg
aatggcaagg agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc
catcgagaaa acaatctcca aagccaaagg gcagccccga 1200 gaaccacagg
tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260
ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat
1320 gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga
cggctccttc 1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc
agcaggggaa cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac
cactacacgc agaagagcct ctccctgtct 1500 ccgggtaaga attatggtgg
cggtggctcg ggcggtggtg gatctggagg aggtgggagt 1560 gggaattctg
acattgtgct cacccaatct ccagcttctt tggctgtgtc tctaggtcag 1620
agagccacca tctcctgcag agccagtgaa agtgttgaat attatgtcac aagtttaatg
1680 cagtggtacc aacagaaacc aggacagcca cccaaactcc tcatctctgc
tgctagcaac 1740 gtagaatctg gggtccctgc caggtttagt ggcagtgggt
ctgggacaga ctttagcctc 1800 aacatccatc ctgtggagga ggatgatatt
gcaatgtatt tctgtcagca aagtaggaag 1860 gttccatgga cgttcggtgg
aggcaccaag ctggaaatca aacggggtgg cggtggatcc 1920 ggcggaggtg
ggtcgggtgg cggcggatct caggtgcagc tgaaggagtc aggacctggc 1980
ctggtggcgc cctcacagag cctgtccatc acatgcaccg tctcagggtt ctcattaacc
2040 ggctatggtg taaactgggt tcgccagcct ccaggaaagg gtctggagtg
gctgggaatg 2100 atatggggtg atggaagcac agactataat tcagctctca
aatccagact atcgatcacc 2160 aaggacaact ccaagagcca agttttctta
aaaatgaaca gtctgcaaac tgatgacaca 2220 gccagatact actgtgctcg
agatggttat agtaactttc attactatgt tatggactac 2280 tggggtcaag
gaacctcagt caccgtctcc tcttaatcta ga 2322 <210> SEQ ID NO 174
<211> LENGTH: 767 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: 2H7sssIgG1-STD1-2e12LH (w/2e12 leader) (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(22) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (23)..(128) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282)
<223> OTHER INFORMATION: Hinge <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(519) <223> OTHER INFORMATION: EFD-BD2 linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (520)..(631) <223> OTHER INFORMATION: VL2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (632)..(646) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (647)..(767) <223> OTHER INFORMATION: VH2
<400> SEQUENCE: 174 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Ser Asp Ile
Val Leu Thr Gln Ser Pro Ala 515 520 525 Ser Leu Ala Val Ser Leu Gly
Gln Arg Ala Thr Ile Ser Cys Arg Ala 530 535 540 Ser Glu Ser Val Glu
Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln 545 550 555 560 Gln Lys
Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 565 570 575
Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 580
585 590 Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala
Met 595 600 605 Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe
Gly Gly Gly 610 615 620 Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly
Ser Gly Gly Gly Gly 625 630 635 640 Ser Gly Gly Gly Gly Ser Gln Val
Gln Leu Lys Glu Ser Gly Pro Gly 645 650 655 Leu Val Ala Pro Ser Gln
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 660 665 670 Phe Ser Leu Thr
Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly 675 680 685 Lys Gly
Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp 690 695 700
Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser 705
710 715 720 Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp
Asp Thr 725 730 735 Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn
Phe His Tyr Tyr 740 745 750 Val Met Asp Tyr Trp Gly Gln Gly Thr Ser
Val Thr Val Ser Ser 755 760 765 <210> SEQ ID NO 175
<211> LENGTH: 767 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: 2H7sssIgG1(P238S/P331S)-STD1-2e12LH (w/2e12 leader)
(AA) <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(22) <223> OTHER INFORMATION:
Leader <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (23)..(128) <223> OTHER INFORMATION: VL
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (129)..(144) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (145)..(265) <223> OTHER INFORMATION: VH
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (268)..(282) <223> OTHER INFORMATION: Hinge
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (500)..(519) <223> OTHER INFORMATION: EFD-BD2
Linker <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (520)..(631) <223> OTHER INFORMATION:
VL2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (632)..(646) <223> OTHER INFORMATION:
Linker2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (647)..(767) <223> OTHER INFORMATION:
VH2 <400> SEQUENCE: 175 Met Asp Phe Gln Val Gln Ile Phe Ser
Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln
Ile Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro
Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val
Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro
Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70
75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
Gln Gln Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser
Gly Ala Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met
His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195
200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Ser Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Ser Asp Ile
Val Leu Thr Gln Ser Pro Ala 515 520 525 Ser Leu Ala Val Ser Leu Gly
Gln Arg Ala Thr Ile Ser Cys Arg Ala 530 535 540 Ser Glu Ser Val Glu
Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln 545 550 555 560 Gln Lys
Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 565 570 575
Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 580
585 590 Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala
Met 595 600 605 Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe
Gly Gly Gly 610 615 620 Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly
Ser Gly Gly Gly Gly 625 630 635 640 Ser Gly Gly Gly Gly Ser Gln Val
Gln Leu Lys Glu Ser Gly Pro Gly 645 650 655 Leu Val Ala Pro Ser Gln
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 660 665 670 Phe Ser Leu Thr
Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly 675 680 685 Lys Gly
Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp 690 695 700
Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser 705
710 715 720 Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp
Asp Thr 725 730 735 Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn
Phe His Tyr Tyr 740 745 750 Val Met Asp Tyr Trp Gly Gln Gly Thr Ser
Val Thr Val Ser Ser 755 760 765 <210> SEQ ID NO 176
<211> LENGTH: 2376 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-STD2-2e12LH (DNA) <400>
SEQUENCE: 176 aagcttgccg ccatggattt tcaagtgcag attttcagct
tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc
tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat
gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga
agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct 240
tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc
300 agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag
ttttaaccca 360 cccacgttcg gtgctgggac caagctggag ctgaaagatg
gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct
tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa
gatgtcctgc aaggcttctg gctacacatt taccagttac 540 aatatgcact
gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat 600
ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta
660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga
agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat agtaactctt
actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat
caggagccca aatcttctga caaaactcac 840 acatccccac cgagcccagc
acctgaactc ctggggggac cgtcagtctt cctcttcccc 900 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 960
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa
acaatctcca aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc
tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1320
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc
1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa
cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc
agaagagcct ctccctgtct 1500 ccgggtaaga attatggtgg cggtggctcg
ggcggtggtg gatctggagg aggtgggagt 1560 gggaattatg gtggcggtgg
ctcgggcggt ggtggatctg gaggaggtgg gagtgggaat 1620 tctgacattg
tgctcaccca atctccagct tctttggctg tgtctctagg tcagagagcc 1680
accatctcct gcagagccag tgaaagtgtt gaatattatg tcacaagttt aatgcagtgg
1740 taccaacaga aaccaggaca gccacccaaa ctcctcatct ctgctgctag
caacgtagaa 1800 tctggggtcc ctgccaggtt tagtggcagt gggtctggga
cagactttag cctcaacatc 1860 catcctgtgg aggaggatga tattgcaatg
tatttctgtc agcaaagtag gaaggttcca 1920 tggacgttcg gtggaggcac
caagctggaa atcaaacggg gtggcggtgg atccggcgga 1980 ggtgggtcgg
gtggcggcgg atctcaggtg cagctgaagg agtcaggacc tggcctggtg 2040
gcgccctcac agagcctgtc catcacatgc accgtctcag ggttctcatt aaccggctat
2100 ggtgtaaact gggttcgcca gcctccagga aagggtctgg agtggctggg
aatgatatgg 2160 ggtgatggaa gcacagacta taattcagct ctcaaatcca
gactatcgat caccaaggac 2220 aactccaaga gccaagtttt cttaaaaatg
aacagtctgc aaactgatga cacagccaga 2280 tactactgtg ctcgagatgg
ttatagtaac tttcattact atgttatgga ctactggggt 2340 caaggaacct
cagtcaccgt ctcctcttaa tctaga 2376 <210> SEQ ID NO 177
<211> LENGTH: 785 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: 2H7sssIgG1-STD2-2e12LH (w/2e12 leader) <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1)..(22) <223> OTHER INFORMATION: Leader <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(129) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(130)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(537) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (538)..(649) <223> OTHER INFORMATION: VL2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (650)..(664) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (665)..(785) <223> OTHER INFORMATION: VH2
<400> SEQUENCE: 177 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser
50 55 60 Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly
Val Pro 65 70 75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr
Ser Leu Thr Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr
Tyr Tyr Cys Gln Gln Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly
Ala Gly Thr Lys Leu Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu
Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser
Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170
175 Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile
180 185 190 Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln
Lys Phe 195 200 205 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser
Ser Thr Ala Tyr 210 215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp
Ser Ala Val Tyr Phe Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser
Asn Ser Tyr Trp Tyr Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr
Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr
His Thr Ser Pro Pro Ser Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295
300 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
305 310 315 320 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
Val Glu Val 325 330 335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
Tyr Asn Ser Thr Tyr 340 345 350 Arg Val Val Ser Val Leu Thr Val Leu
His Gln Asp Trp Leu Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val
Ser Asn Lys Ala Leu Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420
425 430 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
Pro 435 440 445 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
Leu Thr Val 450 455 460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
Ser Cys Ser Val Met 465 470 475 480 His Glu Ala Leu His Asn His Tyr
Thr Gln Lys Ser Leu Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser
Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly 515 520 525 Ser Gly
Gly Gly Gly Ser Gly Asn Ser Asp Ile Val Leu Thr Gln Ser 530 535 540
Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys 545
550 555 560 Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met
Gln Trp 565 570 575 Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu
Ile Ser Ala Ala 580 585 590 Ser Asn Val Glu Ser Gly Val Pro Ala Arg
Phe Ser Gly Ser Gly Ser 595 600 605 Gly Thr Asp Phe Ser Leu Asn Ile
His Pro Val Glu Glu Asp Asp Ile 610 615 620 Ala Met Tyr Phe Cys Gln
Gln Ser Arg Lys Val Pro Trp Thr Phe Gly 625 630 635 640 Gly Gly Thr
Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly 645 650 655 Gly
Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly 660 665
670 Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val
675 680 685 Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg
Gln Pro 690 695 700 Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp
Gly Asp Gly Ser 705 710 715 720 Thr Asp Tyr Asn Ser Ala Leu Lys Ser
Arg Leu Ser Ile Thr Lys Asp 725 730 735 Asn Ser Lys Ser Gln Val Phe
Leu Lys Met Asn Ser Leu Gln Thr Asp 740 745 750 Asp Thr Ala Arg Tyr
Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His 755 760 765 Tyr Tyr Val
Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 770 775 780 Ser
785 <210> SEQ ID NO 178 <211> LENGTH: 785 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1(P238S/P331S)-STD2-2e12LH (w/2e12 leader) (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(22) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (23)..(128) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(281) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(537) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (538)..(649) <223> OTHER INFORMATION: VL2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (650)..(664) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (665)..(785) <223> OTHER INFORMATION: VH2
<400> SEQUENCE: 178 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 340
345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
Ala Ser Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg Asp
Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val Leu
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455 460
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 465
470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Tyr Gly Gly Gly
Gly Ser Gly Gly Gly Gly 515 520 525 Ser Gly Gly Gly Gly Ser Gly Asn
Ser Asp Ile Val Leu Thr Gln Ser 530 535 540 Pro Ala Ser Leu Ala Val
Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys 545 550 555 560 Arg Ala Ser
Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp 565 570 575 Tyr
Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala 580 585
590 Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser
595 600 605 Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp
Asp Ile 610 615 620 Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro
Trp Thr Phe Gly 625 630 635 640 Gly Gly Thr Lys Leu Glu Ile Lys Arg
Gly Gly Gly Gly Ser Gly Gly 645 650 655 Gly Gly Ser Gly Gly Gly Gly
Ser Gln Val Gln Leu Lys Glu Ser Gly 660 665 670 Pro Gly Leu Val Ala
Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val 675 680 685 Ser Gly Phe
Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro 690 695 700 Pro
Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser 705 710
715 720 Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys
Asp 725 730 735 Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu
Gln Thr Asp 740 745 750 Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly
Tyr Ser Asn Phe His 755 760 765 Tyr Tyr Val Met Asp Tyr Trp Gly Gln
Gly Thr Ser Val Thr Val Ser 770 775 780 Ser 785 <210> SEQ ID
NO 179 <211> LENGTH: 2391 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-STD2-2e12HL (DNA) <400>
SEQUENCE: 179 aagcttgccg ccatggattt tcaagtgcag attttcagct
tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc
tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat
gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga
agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct 240
tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc
300 agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag
ttttaaccca 360 cccacgttcg gtgctgggac caagctggag ctgaaagatg
gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct
tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa
gatgtcctgc aaggcttctg gctacacatt taccagttac 540 aatatgcact
gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat 600
ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta
660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga
agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat agtaactctt
actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat
caggagccca aatcttctga caaaactcac 840 acatccccac cgagcccagc
acctgaactc ctggggggac cgtcagtctt cctcttcccc 900 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 960
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa
acaatctcca aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc
tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1320
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc
1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa
cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc
agaagagcct ctccctgtct 1500 ccgggtaaga attatggtgg cggtggctcg
ggcggtggtg gatctggagg aggtgggagt 1560 gggaattatg gtggcggtgg
ctcgggcggt ggtggatctg gaggaggtgg gagtgggaat 1620 tctcaggtgc
agctgaagga gtcaggacct ggcctggtgg cgccctcaca gagcctgtcc 1680
atcacatgca ccgtctcagg gttctcatta accggctatg gtgtaaactg ggttcgccag
1740 cctccaggaa agggtctgga gtggctggga atgatatggg gtgatggaag
cacagactat 1800 aattcagctc tcaaatccag actatcgatc accaaggaca
actccaagag ccaagttttc 1860 ttaaaaatga acagtctgca aactgatgac
acagccagat actactgtgc tcgagatggt 1920 tatagtaact ttcattacta
tgttatggac tactggggtc aaggaacctc agtcaccgtc 1980 tcctctgggg
gtggaggctc tggtggcggt ggatccggcg gaggtgggtc gggtggcggc 2040
ggatctgaca ttgtgctcac ccaatctcca gcttctttgg ctgtgtctct aggtcagaga
2100 gccaccatct cctgcagagc cagtgaaagt gttgaatatt atgtcacaag
tttaatgcag 2160 tggtaccaac agaaaccagg acagccaccc aaactcctca
tctctgctgc tagcaacgta 2220 gaatctgggg tccctgccag gtttagtggc
agtgggtctg ggacagactt tagcctcaac 2280 atccatcctg tggaggagga
tgatattgca atgtatttct gtcagcaaag taggaaggtt 2340 ccatggacgt
tcggtggagg caccaagctg gaaatcaaac gttaatctag a 2391 <210> SEQ
ID NO 180 <211> LENGTH: 790 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-STD2-2e12HL (w/2e12 leader) (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(22) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (23)..(128) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(537) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (538)..(658) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (659)..(678) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (679)..(790) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 180 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140
Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val Arg Pro Gly Ala 145
150 155 160 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
Ser Tyr 165 170 175 Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly
Leu Glu Trp Ile 180 185 190 Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr
Ser Tyr Asn Gln Lys Phe 195 200 205 Lys Gly Lys Ala Thr Leu Thr Val
Asp Lys Ser Ser Ser Thr Ala Tyr 210 215 220 Met Gln Leu Ser Ser Leu
Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 225 230 235 240 Ala Arg Val
Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 245 250 255 Gly
Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 260 265
270 Asp Lys Thr His Thr Ser Pro Pro Ser Ser Ala Pro Glu Leu Leu Gly
275 280 285 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met 290 295 300 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
Asp Val Ser His 305 310 315 320 Glu Asp Pro Glu Val Lys Phe Asn Trp
Tyr Val Asp Gly Val Glu Val 325 330 335 His Asn Ala Lys Thr Lys Pro
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 340 345 350 Arg Val Val Ser Val
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 355 360 365 Lys Glu Tyr
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 370 375 380 Glu
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 385 390
395 400 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
Ser 405 410 415 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu 420 425 430 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro 435 440 445 Val Leu Asp Ser Asp Gly Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val 450 455 460 Asp Lys Ser Arg Trp Gln Gln
Gly Asn Val Phe Ser Cys Ser Val Met 465 470 475 480 His Glu Ala Leu
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 485 490 495 Pro Gly
Lys Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 500 505 510
Gly Gly Gly Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly 515
520 525 Ser Gly Gly Gly Gly Ser Gly Asn Ser Gln Val Gln Leu Lys Glu
Ser 530 535 540 Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile
Thr Cys Thr 545 550 555 560 Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly
Val Asn Trp Val Arg Gln 565 570 575 Pro Pro Gly Lys Gly Leu Glu Trp
Leu Gly Met Ile Trp Gly Asp Gly 580 585 590 Ser Thr Asp Tyr Asn Ser
Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys 595 600 605 Asp Asn Ser Lys
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 610 615 620 Asp Asp
Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe 625 630 635
640 His Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val
645 650 655 Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly 660 665 670 Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln
Ser Pro Ala Ser 675 680 685 Leu Ala Val Ser Leu Gly Gln Arg Ala Thr
Ile Ser Cys Arg Ala Ser 690 695 700 Glu Ser Val Glu Tyr Tyr Val Thr
Ser Leu Met Gln Trp Tyr Gln Gln 705 710 715 720 Lys Pro Gly Gln Pro
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val 725 730 735 Glu Ser Gly
Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 740 745 750 Phe
Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr 755 760
765 Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr
770 775 780 Lys Leu Glu Ile Lys Arg 785 790 <210> SEQ ID NO
181 <211> LENGTH: 790 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1(P238S/P331S)-STD2-2e12HL (w/2e12
leader) (AA) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(22) <223> OTHER
INFORMATION: Leader <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (23)..(128) <223> OTHER
INFORMATION: VL <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (129)..(144) <223> OTHER
INFORMATION: Linker <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (145)..(265) <223> OTHER
INFORMATION: VH <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (268)..(282) <223> OTHER
INFORMATION: Hinge <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (500)..(537) <223> OTHER
INFORMATION: EFD-BD2 Linker <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (538)..(658)
<223> OTHER INFORMATION: VH2 <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (659)..(678)
<223> OTHER INFORMATION: Linker2 <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(679)..(790) <223> OTHER INFORMATION: VL2 <400>
SEQUENCE: 181 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile
Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser
Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly Glu Lys Val
Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser Tyr Met His
Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys Pro Trp Ile
Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80 Ala Arg Phe
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85 90 95 Ser
Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 100 105
110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val
Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp Val Lys Gln
Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala Ile Tyr Pro
Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205 Lys Gly Lys
Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210 215 220 Met
Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 225 230
235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val
Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro
Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro Ser Ser Ala
Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330 335 His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 340 345 350
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 355
360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser
Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435
440 445 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
Val 450 455 460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
Ser Val Met 465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn
Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly 515 520 525 Ser Gly Gly Gly
Gly Ser Gly Asn Ser Gln Val Gln Leu Lys Glu Ser 530 535 540 Gly Pro
Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr 545 550 555
560 Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln
565 570 575 Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly
Asp Gly 580 585 590 Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu
Ser Ile Thr Lys 595 600 605 Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
Met Asn Ser Leu Gln Thr 610 615 620 Asp Asp Thr Ala Arg Tyr Tyr Cys
Ala Arg Asp Gly Tyr Ser Asn Phe 625 630 635 640 His Tyr Tyr Val Met
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 645 650 655 Ser Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 660 665 670 Ser
Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 675 680
685 Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser
690 695 700 Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr
Gln Gln 705 710 715 720 Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser
Ala Ala Ser Asn Val 725 730 735 Glu Ser Gly Val Pro Ala Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp 740 745 750 Phe Ser Leu Asn Ile His Pro
Val Glu Glu Asp Asp Ile Ala Met Tyr 755 760 765 Phe Cys Gln Gln Ser
Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr 770 775 780 Lys Leu Glu
Ile Lys Arg 785 790 <210> SEQ ID NO 182 <211> LENGTH:
2283 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H1-2e12HL (DNA) <400> SEQUENCE: 182 aagcttgccg
ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca 60
gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct
120 ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta
catgcactgg 180 taccagcaga agccaggatc ctcccccaaa ccctggattt
atgccccatc caacctggct 240 tctggagtcc ctgctcgctt cagtggcagt
gggtctggga cctcttactc tctcacaatc 300 agcagagtgg aggctgaaga
tgctgccact tattactgcc agcagtggag ttttaaccca 360 cccacgttcg
gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt 420
ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg
480 aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt
taccagttac 540 aatatgcact gggtaaagca gacacctaga cagggcctgg
aatggattgg agctatttat 600 ccaggaaatg gtgatacttc ctacaatcag
aagttcaagg gcaaggccac actgactgta 660 gacaaatcct ccagcacagc
ctacatgcag ctcagcagcc tgacatctga agactctgcg 720 gtctatttct
gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg 780
ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac
840 acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt
cctcttcccc 900 ccaaaaccca aggacaccct catgatctcc cggacccctg
aggtcacatg cgtggtggtg 960 gacgtgagcc acgaagaccc tgaggtcaag
ttcaactggt acgtggacgg cgtggaggtg 1020 cataatgcca agacaaagcc
gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 1080 gtcctcaccg
tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc 1140
aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga
1200 gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa
ccaggtcagc 1260 ctgacctgcc tggtcaaagg cttctatccc agcgacatcg
ccgtggagtg ggagagcaat 1320 gggcagccgg agaacaacta caagaccacg
cctcccgtgc tggactccga cggctccttc 1380 ttcctctaca gcaagctcac
cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1440 tgctccgtga
tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 1500
ccgggtaaga attctcaggt gcagctgaag gagtcaggac ctggcctggt ggcgccctca
1560 cagagcctgt ccatcacatg caccgtctca gggttctcat taaccggcta
tggtgtaaac 1620 tgggttcgcc agcctccagg aaagggtctg gagtggctgg
gaatgatatg gggtgatgga 1680 agcacagact ataattcagc tctcaaatcc
agactatcga tcaccaagga caactccaag 1740 agccaagttt tcttaaaaat
gaacagtctg caaactgatg acacagccag atactactgt 1800 gctcgagatg
gttatagtaa ctttcattac tatgttatgg actactgggg tcaaggaacc 1860
tcagtcaccg tctcctctgg gggtggaggc tctggtggcg gtggatccgg cggaggtggg
1920 tcgggtggcg gcggatctga cattgtgctc acccaatctc cagcttcttt
ggctgtgtct 1980 ctaggtcaga gagccaccat ctcctgcaga gccagtgaaa
gtgttgaata ttatgtcaca 2040 agtttaatgc agtggtacca acagaaacca
ggacagccac ccaaactcct catctctgct 2100 gctagcaacg tagaatctgg
ggtccctgcc aggtttagtg gcagtgggtc tgggacagac 2160 tttagcctca
acatccatcc tgtggaggag gatgatattg caatgtattt ctgtcagcaa 2220
agtaggaagg ttccatggac gttcggtgga ggcaccaagc tggaaatcaa acgttaatct
2280 aga 2283 <210> SEQ ID NO 183 <211> LENGTH: 754
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H1-2e12HL (w/2e12 leader) (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(22)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(128) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(281) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(501) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (502)..(622) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (623)..(642) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (643)..(754) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 183 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255
Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro Lys Ser Ser 260
265 270 Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu
Gly 275 280 285 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met 290 295 300 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
Val Asp Val Ser His 305 310 315 320 Glu Asp Pro Glu Val Lys Phe Asn
Trp Tyr Val Asp Gly Val Glu Val 325 330 335 His Asn Ala Lys Thr Lys
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 340 345 350 Arg Val Val Ser
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 355 360 365 Lys Glu
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 370 375 380
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 385
390 395 400 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
Val Ser 405 410 415 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu 420 425 430 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro 435 440 445 Val Leu Asp Ser Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val 450 455 460 Asp Lys Ser Arg Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met 465 470 475 480 His Glu Ala
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 485 490 495 Pro
Gly Lys Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu 500 505
510 Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe
515 520 525 Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro
Gly Lys 530 535 540 Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly
Ser Thr Asp Tyr 545 550 555 560 Asn Ser Ala Leu Lys Ser Arg Leu Ser
Ile Thr Lys Asp Asn Ser Lys 565 570 575 Ser Gln Val Phe Leu Lys Met
Asn Ser Leu Gln Thr Asp Asp Thr Ala 580 585 590 Arg Tyr Tyr Cys Ala
Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val 595 600 605 Met Asp Tyr
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 610 615 620 Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 625 630
635 640 Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val
Ser 645 650 655 Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu
Ser Val Glu 660 665 670 Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln
Gln Lys Pro Gly Gln 675 680 685 Pro Pro Lys Leu Leu Ile Ser Ala Ala
Ser Asn Val Glu Ser Gly Val 690 695 700 Pro Ala Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Ser Leu Asn 705 710 715 720 Ile His Pro Val
Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln 725 730 735 Ser Arg
Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 740 745 750
Lys Arg <210> SEQ ID NO 184 <211> LENGTH: 2301
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H2-2e12HL (DNA) <400> SEQUENCE: 184 aagcttgccg
ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca 60
gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct
120 ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta
catgcactgg 180 taccagcaga agccaggatc ctcccccaaa ccctggattt
atgccccatc caacctggct 240 tctggagtcc ctgctcgctt cagtggcagt
gggtctggga cctcttactc tctcacaatc 300 agcagagtgg aggctgaaga
tgctgccact tattactgcc agcagtggag ttttaaccca 360 cccacgttcg
gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt 420
ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg
480 aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt
taccagttac 540 aatatgcact gggtaaagca gacacctaga cagggcctgg
aatggattgg agctatttat 600 ccaggaaatg gtgatacttc ctacaatcag
aagttcaagg gcaaggccac actgactgta 660 gacaaatcct ccagcacagc
ctacatgcag ctcagcagcc tgacatctga agactctgcg 720 gtctatttct
gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg 780
ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac
840 acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt
cctcttcccc 900 ccaaaaccca aggacaccct catgatctcc cggacccctg
aggtcacatg cgtggtggtg 960 gacgtgagcc acgaagaccc tgaggtcaag
ttcaactggt acgtggacgg cgtggaggtg 1020 cataatgcca agacaaagcc
gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 1080 gtcctcaccg
tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc 1140
aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga
1200 gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa
ccaggtcagc 1260 ctgacctgcc tggtcaaagg cttctatccc agcgacatcg
ccgtggagtg ggagagcaat 1320 gggcagccgg agaacaacta caagaccacg
cctcccgtgc tggactccga cggctccttc 1380 ttcctctaca gcaagctcac
cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1440 tgctccgtga
tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 1500
ccgggtaagg gtggcggtgg ctcggggaat tctcaggtgc agctgaagga gtcaggacct
1560 ggcctggtgg cgccctcaca gagcctgtcc atcacatgca ccgtctcagg
gttctcatta 1620 accggctatg gtgtaaactg ggttcgccag cctccaggaa
agggtctgga gtggctggga 1680 atgatatggg gtgatggaag cacagactat
aattcagctc tcaaatccag actatcgatc 1740 accaaggaca actccaagag
ccaagttttc ttaaaaatga acagtctgca aactgatgac 1800 acagccagat
actactgtgc tcgagatggt tatagtaact ttcattacta tgttatggac 1860
tactggggtc aaggaacctc agtcaccgtc tcctctgggg gtggaggctc tggtggcggt
1920 ggatccggcg gaggtgggtc gggtggcggc ggatctgaca ttgtgctcac
ccaatctcca 1980 gcttctttgg ctgtgtctct aggtcagaga gccaccatct
cctgcagagc cagtgaaagt 2040 gttgaatatt atgtcacaag tttaatgcag
tggtaccaac agaaaccagg acagccaccc 2100 aaactcctca tctctgctgc
tagcaacgta gaatctgggg tccctgccag gtttagtggc 2160 agtgggtctg
ggacagactt tagcctcaac atccatcctg tggaggagga tgatattgca 2220
atgtatttct gtcagcaaag taggaaggtt ccatggacgt tcggtggagg caccaagctg
2280 gaaatcaaac gttaatctag a 2301 <210> SEQ ID NO 185
<211> LENGTH: 760 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: 2H7sssIgG1-H2-2e12HL (w/2e12 leader) (AA) <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1)..(22) <223> OTHER INFORMATION: Leader <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(127) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(128)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(507) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (508)..(628) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (629)..(648) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (649)..(760) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 185 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys
115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val
Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp Val Lys Gln
Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala Ile Tyr Pro
Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205 Lys Gly Lys
Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210 215 220 Met
Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 225 230
235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val
Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro
Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330 335 His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 340 345 350
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 355
360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455 460 Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 465 470 475
480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
485 490 495 Pro Gly Lys Gly Gly Gly Gly Ser Gly Asn Ser Gln Val Gln
Leu Lys 500 505 510 Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser
Leu Ser Ile Thr 515 520 525 Cys Thr Val Ser Gly Phe Ser Leu Thr Gly
Tyr Gly Val Asn Trp Val 530 535 540 Arg Gln Pro Pro Gly Lys Gly Leu
Glu Trp Leu Gly Met Ile Trp Gly 545 550 555 560 Asp Gly Ser Thr Asp
Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile 565 570 575 Thr Lys Asp
Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu 580 585 590 Gln
Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser 595 600
605 Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
610 615 620 Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly 625 630 635 640 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val
Leu Thr Gln Ser Pro 645 650 655 Ala Ser Leu Ala Val Ser Leu Gly Gln
Arg Ala Thr Ile Ser Cys Arg 660 665 670 Ala Ser Glu Ser Val Glu Tyr
Tyr Val Thr Ser Leu Met Gln Trp Tyr 675 680 685 Gln Gln Lys Pro Gly
Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser 690 695 700 Asn Val Glu
Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 705 710 715 720
Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala 725
730 735 Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly
Gly 740 745 750 Gly Thr Lys Leu Glu Ile Lys Arg 755 760 <210>
SEQ ID NO 186 <211> LENGTH: 2307 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sssIgG1-H3-2e12HL (DNA)
<400> SEQUENCE: 186 aagcttgccg ccatggattt tcaagtgcag
attttcagct tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca
aattgttctc tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga
aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180
taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct
240 tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc
tctcacaatc 300 agcagagtgg aggctgaaga tgctgccact tattactgcc
agcagtggag ttttaaccca 360 cccacgttcg gtgctgggac caagctggag
ctgaaagatg gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag
ctctcaggct tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg
cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac 540
aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat
600 ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac
actgactgta 660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc
tgacatctga agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat
agtaactctt actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac
cgtctctgat caggagccca aatcttctga caaaactcac 840 acatccccac
cgagcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc 900
ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg
960 gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg
cgtggaggtg 1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca
gcacgtaccg tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg
aatggcaagg agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc
catcgagaaa acaatctcca aagccaaagg gcagccccga 1200 gaaccacagg
tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260
ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat
1320 gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga
cggctccttc 1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc
agcaggggaa cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac
cactacacgc agaagagcct ctccctgtct 1500 ccgggtaaga attatggtgg
cggtggctct gggaattctc aggtgcagct gaaggagtca 1560 ggacctggcc
tggtggcgcc ctcacagagc ctgtccatca catgcaccgt ctcagggttc 1620
tcattaaccg gctatggtgt aaactgggtt cgccagcctc caggaaaggg tctggagtgg
1680 ctgggaatga tatggggtga tggaagcaca gactataatt cagctctcaa
atccagacta 1740 tcgatcacca aggacaactc caagagccaa gttttcttaa
aaatgaacag tctgcaaact 1800 gatgacacag ccagatacta ctgtgctcga
gatggttata gtaactttca ttactatgtt 1860 atggactact ggggtcaagg
aacctcagtc accgtctcct ctgggggtgg aggctctggt 1920 ggcggtggat
ccggcggagg tgggtcgggt ggcggcggat ctgacattgt gctcacccaa 1980
tctccagctt ctttggctgt gtctctaggt cagagagcca ccatctcctg cagagccagt
2040 gaaagtgttg aatattatgt cacaagttta atgcagtggt accaacagaa
accaggacag 2100 ccacccaaac tcctcatctc tgctgctagc aacgtagaat
ctggggtccc tgccaggttt 2160 agtggcagtg ggtctgggac agactttagc
ctcaacatcc atcctgtgga ggaggatgat 2220 attgcaatgt atttctgtca
gcaaagtagg aaggttccat ggacgttcgg tggaggcacc 2280 aagctggaaa
tcaaacgtta atctaga 2307 <210> SEQ ID NO 187 <211>
LENGTH: 762 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H3-2e12HL (w/2e12 leader) (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(22)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(128) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(509) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (510)..(630) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (631)..(650) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (651)..(762) <223> OTHER INFORMATION:
VL2 <400> SEQUENCE: 187 Met Asp Phe Gln Val Gln Ile Phe Ser
Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln
Ile Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro
Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val
Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro
Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70
75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
Gln Gln Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser
Gly Ala Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met
His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195
200 205 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
Tyr 210 215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
Tyr Phe Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr
Trp Tyr Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val
Ser Asp Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser
Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315
320 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
325 330 335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr 340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
Trp Leu Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440
445 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
450 455 460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met 465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly
Ser Gly Asn Ser Gln Val Gln 500 505 510 Leu Lys Glu Ser Gly Pro Gly
Leu Val Ala Pro Ser Gln Ser Leu Ser 515 520 525 Ile Thr Cys Thr Val
Ser Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn 530 535 540 Trp Val Arg
Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile 545 550 555 560
Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu 565
570 575 Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met
Asn 580 585 590 Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala
Arg Asp Gly 595 600 605 Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr
Trp Gly Gln Gly Thr 610 615 620 Ser Val Thr Val Ser Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser 625 630 635 640 Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 645 650 655 Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 660 665 670 Cys Arg
Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln 675 680 685
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala 690
695 700 Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
Gly 705 710 715 720 Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val
Glu Glu Asp Asp 725 730 735 Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg
Lys Val Pro Trp Thr Phe 740 745 750 Gly Gly Gly Thr Lys Leu Glu Ile
Lys Arg 755 760 <210> SEQ ID NO 188 <211> LENGTH: 2316
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H4-2e12HL (DNA) <400> SEQUENCE: 188 aagcttgccg
ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca 60
gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct
120 ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta
catgcactgg 180 taccagcaga agccaggatc ctcccccaaa ccctggattt
atgccccatc caacctggct 240 tctggagtcc ctgctcgctt cagtggcagt
gggtctggga cctcttactc tctcacaatc 300 agcagagtgg aggctgaaga
tgctgccact tattactgcc agcagtggag ttttaaccca 360 cccacgttcg
gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt 420
ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg
480 aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt
taccagttac 540 aatatgcact gggtaaagca gacacctaga cagggcctgg
aatggattgg agctatttat 600 ccaggaaatg gtgatacttc ctacaatcag
aagttcaagg gcaaggccac actgactgta 660 gacaaatcct ccagcacagc
ctacatgcag ctcagcagcc tgacatctga agactctgcg 720 gtctatttct
gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg 780
ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac
840 acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt
cctcttcccc 900 ccaaaaccca aggacaccct catgatctcc cggacccctg
aggtcacatg cgtggtggtg 960 gacgtgagcc acgaagaccc tgaggtcaag
ttcaactggt acgtggacgg cgtggaggtg 1020 cataatgcca agacaaagcc
gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 1080 gtcctcaccg
tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc 1140
aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga
1200 gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa
ccaggtcagc 1260 ctgacctgcc tggtcaaagg cttctatccc agcgacatcg
ccgtggagtg ggagagcaat 1320 gggcagccgg agaacaacta caagaccacg
cctcccgtgc tggactccga cggctccttc 1380 ttcctctaca gcaagctcac
cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1440 tgctccgtga
tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 1500
ccgggtaagg gtggcggtgg ctcgggcggt ggtggatctg ggaattctca ggtgcagctg
1560 aaggagtcag gacctggcct ggtggcgccc tcacagagcc tgtccatcac
atgcaccgtc 1620 tcagggttct cattaaccgg ctatggtgta aactgggttc
gccagcctcc aggaaagggt 1680 ctggagtggc tgggaatgat atggggtgat
ggaagcacag actataattc agctctcaaa 1740 tccagactat cgatcaccaa
ggacaactcc aagagccaag ttttcttaaa aatgaacagt 1800 ctgcaaactg
atgacacagc cagatactac tgtgctcgag atggttatag taactttcat 1860
tactatgtta tggactactg gggtcaagga acctcagtca ccgtctcctc tgggggtgga
1920 ggctctggtg gcggtggatc cggcggaggt gggtcgggtg gcggcggatc
tgacattgtg 1980 ctcacccaat ctccagcttc tttggctgtg tctctaggtc
agagagccac catctcctgc 2040 agagccagtg aaagtgttga atattatgtc
acaagtttaa tgcagtggta ccaacagaaa 2100 ccaggacagc cacccaaact
cctcatctct gctgctagca acgtagaatc tggggtccct 2160 gccaggttta
gtggcagtgg gtctgggaca gactttagcc tcaacatcca tcctgtggag 2220
gaggatgata ttgcaatgta tttctgtcag caaagtagga aggttccatg gacgttcggt
2280 ggaggcacca agctggaaat caaacgttaa tctaga 2316 <210> SEQ
ID NO 189 <211> LENGTH: 765 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-H4-2e12HL (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(22)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(128)
<223> OTHER INFORMATION: VL <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (129)..(144)
<223> OTHER INFORMATION: Linker <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(512) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (513)..(633) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (634)..(653) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (654)..(765) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 189 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Pro Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Asn Ser 500 505 510 Gln Val Gln Leu Lys Glu Ser Gly Pro
Gly Leu Val Ala Pro Ser Gln 515 520 525 Ser Leu Ser Ile Thr Cys Thr
Val Ser Gly Phe Ser Leu Thr Gly Tyr 530 535 540 Gly Val Asn Trp Val
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 545 550 555 560 Gly Met
Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 565 570 575
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 580
585 590 Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys
Ala 595 600 605 Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp
Tyr Trp Gly 610 615 620 Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly
Gly Gly Ser Gly Gly 625 630 635 640 Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Asp Ile Val 645 650 655 Leu Thr Gln Ser Pro Ala
Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 660 665 670 Thr Ile Ser Cys
Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser 675 680 685 Leu Met
Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 690 695 700
Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser 705
710 715 720 Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro
Val Glu 725 730 735 Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
Arg Lys Val Pro 740 745 750 Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu
Ile Lys Arg 755 760 765 <210> SEQ ID NO 190 <211>
LENGTH: 2322 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
2H7sssIgG1-H5-2e12HL (DNA) <400> SEQUENCE: 190 aagcttgccg
ccatggattt tcaagtgcag attttcagct tcctgctaat cagtgcttca 60
gtcataatgt ccagaggaca aattgttctc tcccagtctc cagcaatcct gtctgcatct
120 ccaggggaga aggtcacaat gacttgcagg gccagctcaa gtgtaagtta
catgcactgg 180 taccagcaga agccaggatc ctcccccaaa ccctggattt
atgccccatc caacctggct 240 tctggagtcc ctgctcgctt cagtggcagt
gggtctggga cctcttactc tctcacaatc 300 agcagagtgg aggctgaaga
tgctgccact tattactgcc agcagtggag ttttaaccca 360 cccacgttcg
gtgctgggac caagctggag ctgaaagatg gcggtggctc gggcggtggt 420
ggatctggag gaggtgggag ctctcaggct tatctacagc agtctggggc tgagtcggtg
480 aggcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt
taccagttac 540 aatatgcact gggtaaagca gacacctaga cagggcctgg
aatggattgg agctatttat 600 ccaggaaatg gtgatacttc ctacaatcag
aagttcaagg gcaaggccac actgactgta 660 gacaaatcct ccagcacagc
ctacatgcag ctcagcagcc tgacatctga agactctgcg 720 gtctatttct
gtgcaagagt ggtgtactat agtaactctt actggtactt cgatgtctgg 780
ggcacaggga ccacggtcac cgtctctgat caggagccca aatcttctga caaaactcac
840 acatccccac cgagcccagc acctgaactc ctggggggac cgtcagtctt
cctcttcccc 900 ccaaaaccca aggacaccct catgatctcc cggacccctg
aggtcacatg cgtggtggtg 960 gacgtgagcc acgaagaccc tgaggtcaag
ttcaactggt acgtggacgg cgtggaggtg 1020 cataatgcca agacaaagcc
gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 1080 gtcctcaccg
tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc 1140
aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga
1200 gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa
ccaggtcagc 1260 ctgacctgcc tggtcaaagg cttctatccc agcgacatcg
ccgtggagtg ggagagcaat 1320 gggcagccgg agaacaacta caagaccacg
cctcccgtgc tggactccga cggctccttc 1380 ttcctctaca gcaagctcac
cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1440 tgctccgtga
tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 1500
ccgggtaaga attatggtgg cggtggctcg ggcggtggtg gatctgggaa ttctcaggtg
1560 cagctgaagg agtcaggacc tggcctggtg gcgccctcac agagcctgtc
catcacatgc 1620 accgtctcag ggttctcatt aaccggctat ggtgtaaact
gggttcgcca gcctccagga 1680 aagggtctgg agtggctggg aatgatatgg
ggtgatggaa gcacagacta taattcagct 1740 ctcaaatcca gactatcgat
caccaaggac aactccaaga gccaagtttt cttaaaaatg 1800 aacagtctgc
aaactgatga cacagccaga tactactgtg ctcgagatgg ttatagtaac 1860
tttcattact atgttatgga ctactggggt caaggaacct cagtcaccgt ctcctctggg
1920 ggtggaggct ctggtggcgg tggatccggc ggaggtgggt cgggtggcgg
cggatctgac 1980
attgtgctca cccaatctcc agcttctttg gctgtgtctc taggtcagag agccaccatc
2040 tcctgcagag ccagtgaaag tgttgaatat tatgtcacaa gtttaatgca
gtggtaccaa 2100 cagaaaccag gacagccacc caaactcctc atctctgctg
ctagcaacgt agaatctggg 2160 gtccctgcca ggtttagtgg cagtgggtct
gggacagact ttagcctcaa catccatcct 2220 gtggaggagg atgatattgc
aatgtatttc tgtcagcaaa gtaggaaggt tccatggacg 2280 ttcggtggag
gcaccaagct ggaaatcaaa cgttaatcta ga 2322 <210> SEQ ID NO 191
<211> LENGTH: 767 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: 2H7sssIgG1-H5-2e12HL (w/2e12 leader) (AA) <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1)..(22) <223> OTHER INFORMATION: Leader <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(23)..(128) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(500)..(514) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (515)..(635) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (636)..(655) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (656)..(767) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 191 Met Asp Phe Gln Val Gln Ile Phe Ser Phe
Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile
Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly
Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser
Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys
Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85
90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala
Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp
Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro
Ser Pro Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330
335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg
Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455
460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 500 505 510 Asn Ser Gln Val Gln Leu Lys Glu Ser
Gly Pro Gly Leu Val Ala Pro 515 520 525 Ser Gln Ser Leu Ser Ile Thr
Cys Thr Val Ser Gly Phe Ser Leu Thr 530 535 540 Gly Tyr Gly Val Asn
Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 545 550 555 560 Trp Leu
Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala 565 570 575
Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val 580
585 590 Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr
Tyr 595 600 605 Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val
Met Asp Tyr 610 615 620 Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
Gly Gly Gly Gly Ser 625 630 635 640 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Asp 645 650 655 Ile Val Leu Thr Gln Ser
Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 660 665 670 Arg Ala Thr Ile
Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val 675 680 685 Thr Ser
Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 690 695 700
Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg 705
710 715 720 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile
His Pro 725 730 735 Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln
Gln Ser Arg Lys 740 745 750 Val Pro Trp Thr Phe Gly Gly Gly Thr Lys
Leu Glu Ile Lys Arg 755 760 765 <210> SEQ ID NO 192
<211> LENGTH: 2331 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-H6-2e12HL (DNA) <400> SEQUENCE:
192 aagcttgccg ccatggattt tcaagtgcag attttcagct tcctgctaat
cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc tcccagtctc
cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat gacttgcagg
gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga agccaggatc
ctcccccaaa ccctggattt atgccccatc caacctggct 240 tctggagtcc
ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc 300
agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag ttttaaccca
360 cccacgttcg gtgctgggac caagctggag ctgaaagatg gcggtggctc
gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct tatctacagc
agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa gatgtcctgc
aaggcttctg gctacacatt taccagttac 540 aatatgcact gggtaaagca
gacacctaga cagggcctgg aatggattgg agctatttat 600 ccaggaaatg
gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta 660
gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga agactctgcg
720 gtctatttct gtgcaagagt ggtgtactat agtaactctt actggtactt
cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat caggagccca
aatcttctga caaaactcac 840 acatccccac cgagcccagc acctgaactc
ctggggggac cgtcagtctt cctcttcccc 900 ccaaaaccca aggacaccct
catgatctcc cggacccctg aggtcacatg cgtggtggtg 960 gacgtgagcc
acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 1020
cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc
1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg
caaggtctcc 1140
aacaaagccc tcccagcccc catcgagaaa acaatctcca aagccaaagg gcagccccga
1200 gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa
ccaggtcagc 1260 ctgacctgcc tggtcaaagg cttctatccc agcgacatcg
ccgtggagtg ggagagcaat 1320 gggcagccgg agaacaacta caagaccacg
cctcccgtgc tggactccga cggctccttc 1380 ttcctctaca gcaagctcac
cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1440 tgctccgtga
tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 1500
ccgggtaagg gtggcggtgg ctcgggcggt ggtggatctg ggggaggagg cagcgggaat
1560 tctcaggtgc agctgaagga gtcaggacct ggcctggtgg cgccctcaca
gagcctgtcc 1620 atcacatgca ccgtctcagg gttctcatta accggctatg
gtgtaaactg ggttcgccag 1680 cctccaggaa agggtctgga gtggctggga
atgatatggg gtgatggaag cacagactat 1740 aattcagctc tcaaatccag
actatcgatc accaaggaca actccaagag ccaagttttc 1800 ttaaaaatga
acagtctgca aactgatgac acagccagat actactgtgc tcgagatggt 1860
tatagtaact ttcattacta tgttatggac tactggggtc aaggaacctc agtcaccgtc
1920 tcctctgggg gtggaggctc tggtggcggt ggatccggcg gaggtgggtc
gggtggcggc 1980 ggatctgaca ttgtgctcac ccaatctcca gcttctttgg
ctgtgtctct aggtcagaga 2040 gccaccatct cctgcagagc cagtgaaagt
gttgaatatt atgtcacaag tttaatgcag 2100 tggtaccaac agaaaccagg
acagccaccc aaactcctca tctctgctgc tagcaacgta 2160 gaatctgggg
tccctgccag gtttagtggc agtgggtctg ggacagactt tagcctcaac 2220
atccatcctg tggaggagga tgatattgca atgtatttct gtcagcaaag taggaaggtt
2280 ccatggacgt tcggtggagg caccaagctg gaaatcaaac gttaatctag a 2331
<210> SEQ ID NO 193 <211> LENGTH: 770 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sssIgG1-H6-2e12HL (w/2e12 leader)
(AA) <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(22) <223> OTHER INFORMATION:
Leader <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (23)..(128) <223> OTHER INFORMATION: VL
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (129)..(144) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (145)..(265) <223> OTHER INFORMATION: VH
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (268)..(282) <223> OTHER INFORMATION: Hinge
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (500)..(517) <223> OTHER INFORMATION: EFD-BD2
Linker <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (518)..(638) <223> OTHER INFORMATION:
VH2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (639)..(658) <223> OTHER INFORMATION:
Linker2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (659)..(770) <223> OTHER INFORMATION:
VL2 <400> SEQUENCE: 193 Met Asp Phe Gln Val Gln Ile Phe Ser
Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln
Ile Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro
Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val
Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro
Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70
75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
Gln Gln Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser
Gly Ala Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met
His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195
200 205 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
Tyr 210 215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
Tyr Phe Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr
Trp Tyr Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val
Ser Asp Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser
Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315
320 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
325 330 335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr 340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
Trp Leu Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440
445 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
450 455 460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met 465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser 485 490 495 Pro Gly Lys Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly 500 505 510 Gly Ser Gly Asn Ser Gln Val
Gln Leu Lys Glu Ser Gly Pro Gly Leu 515 520 525 Val Ala Pro Ser Gln
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe 530 535 540 Ser Leu Thr
Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys 545 550 555 560
Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr 565
570 575 Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser
Lys 580 585 590 Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp
Asp Thr Ala 595 600 605 Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn
Phe His Tyr Tyr Val 610 615 620 Met Asp Tyr Trp Gly Gln Gly Thr Ser
Val Thr Val Ser Ser Gly Gly 625 630 635 640 Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 645 650 655 Gly Ser Asp Ile
Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 660 665 670 Leu Gly
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu 675 680 685
Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln 690
695 700 Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly
Val 705 710 715 720 Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Ser Leu Asn 725 730 735 Ile His Pro Val Glu Glu Asp Asp Ile Ala
Met Tyr Phe Cys Gln Gln 740 745 750 Ser Arg Lys Val Pro Trp Thr Phe
Gly Gly Gly Thr Lys Leu Glu Ile 755 760 765 Lys Arg 770 <210>
SEQ ID NO 194 <211> LENGTH: 2301 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sscIgG1-H7-2e12HL (DNA)
<400> SEQUENCE: 194 aagcttgccg ccatggattt tcaagtgcag
attttcagct tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca
aattgttctc tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga
aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180
taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct
240
tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc
300 agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag
ttttaaccca 360 cccacgttcg gtgctgggac caagctggag ctgaaagatg
gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct
tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa
gatgtcctgc aaggcttctg gctacacatt taccagttac 540 aatatgcact
gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat 600
ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta
660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga
agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat agtaactctt
actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat
caggagccca aatcttctga caaaactcac 840 acatccccac cgtgcccagc
acctgaactc ctggggggat cgtcagtctt cctcttcccc 900 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 960
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa
accatctcca aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc
tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat 1320
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc
1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa
cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc
agaagagcct ctccctgtct 1500 ccgggtaagg ggtgtccacc ttgtccgaat
tctcaggtgc agctgaagga gtcagggcct 1560 ggcagcgtgg cgccctcaca
gagcctgtcc atcacatgca ccgtctcagg gttctcatta 1620 accggctatg
gtgtaaactg ggttcgccag cctccaggaa agggtctgga gtggctggga 1680
atgatatggg gtgatggaag cacagactat aattcagctc tcaaatccag actatcgatc
1740 accaaggaca actccaagag ccaagttttc ttaaaaatga acagtctgca
aactgatgac 1800 acagccagat actactgtgc tcgagatggt tatagtaact
ttcattacta tgttatggac 1860 tactggggtc aaggaacctc agtcaccgtc
tcctctgggg gtggaggctc tggtggcggt 1920 ggatccggcg gaggtgggtc
gggtggcggc ggatctgaca ttgtgctcac ccaatctcca 1980 gcttctttgg
ctgtgtctct aggtcagaga gccaccatct cctgcagagc cagtgaaagt 2040
gttgaatatt atgtcacaag tttaatgcag tggtaccaac agaaaccagg acagccaccc
2100 aagctcctca tctctgctgc tagcaacgta gaatctgggg tccctgccag
gtttagtggc 2160 agtgggtctg ggacagactt tagcctcaac atccatcctg
tggaggagga tgatattgca 2220 atgtatttct gtcagcaaag taggaaggtt
ccatggacgt tcggtggagg caccaagctg 2280 gaaatcaaac gttaatctag a 2301
<210> SEQ ID NO 195 <211> LENGTH: 760 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sscIgG1-H7-2e12HL (w/2e12 linker
) (AA) <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(22) <223> OTHER INFORMATION:
Leader <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (23)..(128) <223> OTHER INFORMATION: VL
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (129)..(144) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (145)..(265) <223> OTHER INFORMATION: VH
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (268)..(282) <223> OTHER INFORMATION: Hinge
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (500)..(507) <223> OTHER INFORMATION: EFD-BD2
Linker <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (508)..(628) <223> OTHER INFORMATION:
VH2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (629)..(648) <223> OTHER INFORMATION:
Linker2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (649)..(760) <223> OTHER INFORMATION:
VL2 <400> SEQUENCE: 195 Met Asp Phe Gln Val Gln Ile Phe Ser
Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln
Ile Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro
Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val
Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro
Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70
75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
Gln Gln Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser
Gly Ala Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met
His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195
200 205 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
Tyr 210 215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
Tyr Phe Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr
Trp Tyr Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val
Ser Asp Gln Glu Pro Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315
320 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
325 330 335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr 340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
Trp Leu Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440
445 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
450 455 460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met 465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser 485 490 495 Pro Gly Lys Gly Cys Pro Pro Cys Pro
Asn Ser Gln Val Gln Leu Lys 500 505 510 Glu Ser Gly Pro Gly Ser Val
Ala Pro Ser Gln Ser Leu Ser Ile Thr 515 520 525 Cys Thr Val Ser Gly
Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val 530 535 540 Arg Gln Pro
Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly 545 550 555 560
Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile 565
570 575 Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser
Leu 580 585 590 Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp
Gly Tyr Ser 595 600 605 Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly
Gln Gly Thr Ser Val 610 615 620 Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly 625 630 635 640 Gly Gly Ser Gly Gly Gly
Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 645 650 655 Ala Ser Leu Ala
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 660 665 670 Ala Ser
Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr 675 680 685
Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser 690
695 700 Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser
Gly 705 710 715 720
Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala 725
730 735 Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly
Gly 740 745 750 Gly Thr Lys Leu Glu Ile Lys Arg 755 760 <210>
SEQ ID NO 196 <211> LENGTH: 2283 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sssIgG1-H7-G194 HL (DNA)
<400> SEQUENCE: 196 aagcttgccg ccatggattt tcaagtgcag
attttcagct tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca
aattgttctc tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga
aggtcacaat gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180
taccagcaga agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct
240 tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc
tctcacaatc 300 agcagagtgg aggctgaaga tgctgccact tattactgcc
agcagtggag ttttaaccca 360 cccacgttcg gtgctgggac caagctggag
ctgaaagatg gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag
ctctcaggct tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg
cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac 540
aatatgcact gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat
600 ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac
actgactgta 660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc
tgacatctga agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat
agtaactctt actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac
cgtctctgat caggagccca aatcttctga caaaactcac 840 acatccccac
cgtgcccagc acctgaactc ctggggggat cgtcagtctt cctcttcccc 900
ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg
960 gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg
cgtggaggtg 1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca
gcacgtaccg tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg
aatggcaagg agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc
catcgagaaa accatctcca aagccaaagg gcagccccga 1200 gaaccacagg
tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260
ctgacctgcc tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat
1320 gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga
cggctccttc 1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc
agcaggggaa cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac
cactacacgc agaagagcct ctccctgtct 1500 ccgggtaagg ggtgtccacc
ttgtccgaat tctgaggtcc agctgcaaca gtctggacct 1560 gaactggtga
agcctggagc ttcaatgaag atttcctgca aggcctctgg ttactcattc 1620
actggctaca tcgtgaactg gctgaagcag agccatggaa agaaccttga gtggattgga
1680 cttattaatc catacaaagg tcttactacc tacaaccaga aattcaaggg
caaggccaca 1740 ttaactgtag acaagtcatc cagcacagcc tacatggagc
tcctcagtct gacatctgaa 1800 gactctgcag tctattactg tgcaagatct
gggtactatg gtgactcgga ctggtacttc 1860 gatgtctggg gcgcagggac
cacggtcacc gtctcctctg gtggcggtgg ctcgggcggt 1920 ggtggatctg
gaggaggtgg gagcgctagc gacatccaga tgacacagac tacatcctcc 1980
ctgtctgcct ctctgggaga cagagtcacc atcagttgca gggcaagtca ggacattcgc
2040 aattatttaa actggtatca gcagaaacca gatggaactg ttaaactcct
gatctactac 2100 acatcaagat tacactcagg agtcccatca aggttcagtg
gcagtgggtc tggaacagat 2160 tattctctca ccattgccaa cctgcaacca
gaagatattg ccacttactt ttgccaacag 2220 ggtaatacgc ttccgtggac
gttcggtgga ggcaccaaac tggtaaccaa acggtaatct 2280 aga 2283
<210> SEQ ID NO 197 <211> LENGTH: 754 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sssIgG1-H7-G194 HL (w/2e12
leader) (AA) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(22) <223> OTHER
INFORMATION: Leader <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (23)..(128) <223> OTHER
INFORMATION: VL <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (129)..(144) <223> OTHER
INFORMATION: Linker <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (145)..(265) <223> OTHER
INFORMATION: VH1 <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (268)..(282) <223> OTHER
INFORMATION: Hinge <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (500)..(507) <223> OTHER
INFORMATION: EFD-BD2 Linker <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (508)..(629)
<223> OTHER INFORMATION: VH2 <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (630)..(646)
<223> OTHER INFORMATION: Linker2 <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(647)..(754) <223> OTHER INFORMATION: VL2 <400>
SEQUENCE: 197 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile
Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser
Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly Glu Lys Val
Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser Tyr Met His
Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys Pro Trp Ile
Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80 Ala Arg Phe
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85 90 95 Ser
Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 100 105
110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val
Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp Val Lys Gln
Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala Ile Tyr Pro
Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205 Lys Gly Lys
Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210 215 220 Met
Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 225 230
235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val
Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro
Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330 335 His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 340 345 350
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 355
360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445 Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450 455 460 Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 465 470 475
480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
485 490 495 Pro Gly Lys Gly Cys Pro Pro Cys Pro Asn Ser Glu Val Gln
Leu Gln 500 505 510 Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser
Met Lys Ile Ser 515 520 525 Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly
Tyr Ile Val Asn Trp Leu 530 535 540 Lys Gln Ser His Gly Lys Asn Leu
Glu Trp Ile Gly Leu Ile Asn Pro 545 550 555 560 Tyr Lys Gly Leu Thr
Thr Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 565 570 575
Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser 580
585 590 Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly
Tyr 595 600 605 Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Ala
Gly Thr Thr 610 615 620 Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly 625 630 635 640 Gly Gly Gly Ser Ala Ser Asp Ile
Gln Met Thr Gln Thr Thr Ser Ser 645 650 655 Leu Ser Ala Ser Leu Gly
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 660 665 670 Gln Asp Ile Arg
Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 675 680 685 Thr Val
Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val 690 695 700
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 705
710 715 720 Ile Ala Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys
Gln Gln 725 730 735 Gly Asn Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Val Thr 740 745 750 Lys Arg <210> SEQ ID NO 198
<211> LENGTH: 2298 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-H7-G281 HL (DNA) <400>
SEQUENCE: 198 aagcttgccg ccatggattt tcaagtgcag attttcagct
tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc
tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat
gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga
agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct 240
tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc
300 agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag
ttttaaccca 360 cccacgttcg gtgctgggac caagctggag ctgaaagatg
gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct
tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa
gatgtcctgc aaggcttctg gctacacatt taccagttac 540 aatatgcact
gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat 600
ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta
660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga
agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat agtaactctt
actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat
caggagccca aatcttctga caaaactcac 840 acatccccac cgtgcccagc
acctgaactc ctggggggat cgtcagtctt cctcttcccc 900 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 960
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa
accatctcca aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc
tggtcaaagg cttctatcca agcgacatcg ccgtggagtg ggagagcaat 1320
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc
1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa
cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc
agaagagcct ctccctgtct 1500 ccgggtaagg ggtgtccacc ttgtccgaat
tctgaggtcc agctgcaaca gtctggacct 1560 gaactggtga agcctggagc
ttcaatgaag atttcctgca aggcctctgg ttactcattc 1620 actggctaca
tcgtgaactg gctgaagcag agccatggaa agaaccttga gtggattgga 1680
cttattaatc catacaaagg tcttactacc tacaaccaga aattcaaggg caaggccaca
1740 ttaactgtag acaagtcatc cagcacagcc tacatggagc tcctcagtct
gacatctgaa 1800 gactctgcag tctattactg tgcaagatct gggtactatg
gtgactcgga ctggtacttc 1860 gatgtctggg gcgcagggac cacggtcacc
gtctcctctg gtggcggtgg ctcgggcggt 1920 ggtggatctg gaggaggtgg
gagcggggga ggtggcagtg ctagcgacat ccagatgaca 1980 cagactacat
cctccctgtc tgcctctctg ggagacagag tcaccatcag ttgcagggca 2040
agtcaggaca ttcgcaatta tttaaactgg tatcagcaga aaccagatgg aactgttaaa
2100 ctcctgatct actacacatc aagattacac tcaggagtcc catcaaggtt
cagtggcagt 2160 gggtctggaa cagattattc tctcaccatt gccaacctgc
aaccagaaga tattgccact 2220 tacttttgcc aacagggtaa tacgcttccg
tggacgttcg gtggaggcac caaactggta 2280 accaaacggt aatctaga 2298
<210> SEQ ID NO 199 <211> LENGTH: 759 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: 2H7sssIgG1-H7-G281 HL (w/2e12
leader) (AA) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(22) <223> OTHER
INFORMATION: Leader <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (23)..(128) <223> OTHER
INFORMATION: VL1 <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (129)..(144) <223> OTHER
INFORMATION: Linker <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (145)..(265) <223> OTHER
INFORMATION: VH1 <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (268)..(282) <223> OTHER
INFORMATION: Hinge <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (500)..(507) <223> OTHER
INFORMATION: EFD-BD2 Linker <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (508)..(629)
<223> OTHER INFORMATION: VH2 <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (630)..(651)
<223> OTHER INFORMATION: Linker2 <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(652)..(759) <223> OTHER INFORMATION: VL2 <400>
SEQUENCE: 199 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile
Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser
Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro Gly Glu Lys Val
Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val Ser Tyr Met His
Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro Lys Pro Trp Ile
Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80 Ala Arg Phe
Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85 90 95 Ser
Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 100 105
110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Ser Val
Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met Ser Cys Lys Ala Ser
Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met His Trp Val Lys Gln
Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190 Gly Ala Ile Tyr Pro
Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195 200 205 Lys Gly Lys
Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210 215 220 Met
Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 225 230
235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val
Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val Ser Asp Gln Glu Pro
Lys Ser Ser 260 265 270 Asp Lys Thr His Thr Ser Pro Pro Cys Pro Ala
Pro Glu Leu Leu Gly 275 280 285 Gly Ser Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His 305 310 315 320 Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 325 330 335 His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 340 345 350
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 355
360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp Glu Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440 445
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 450
455 460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
Met 465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser 485 490 495 Pro Gly Lys Gly Cys Pro Pro Cys Pro Asn
Ser Glu Val Gln Leu Gln 500 505 510 Gln Ser Gly Pro Glu Leu Val Lys
Pro Gly Ala Ser Met Lys Ile Ser 515 520 525 Cys Lys Ala Ser Gly Tyr
Ser Phe Thr Gly Tyr Ile Val Asn Trp Leu 530 535 540 Lys Gln Ser His
Gly Lys Asn Leu Glu Trp Ile Gly Leu Ile Asn Pro 545 550 555 560 Tyr
Lys Gly Leu Thr Thr Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 565 570
575 Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser
580 585 590 Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser
Gly Tyr 595 600 605 Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly
Ala Gly Thr Thr 610 615 620 Val Thr Val Ser Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly 625 630 635 640 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Ala Ser Asp Ile Gln Met Thr 645 650 655 Gln Thr Thr Ser Ser
Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 660 665 670 Ser Cys Arg
Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln 675 680 685 Gln
Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg 690 695
700 Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
705 710 715 720 Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro Glu Asp
Ile Ala Thr 725 730 735 Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp
Thr Phe Gly Gly Gly 740 745 750 Thr Lys Leu Val Thr Lys Arg 755
<210> SEQ ID NO 200 <211> LENGTH: 1533 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: 2e12-sss-IgG1 HL SMIP (DNA)
<400> SEQUENCE: 200 atggattttc aagtgcagat tttcagcttc
ctgctaatca gtgcttcagt cataatgtcc 60 agaggagtcc aggtgcagct
gaaggagtca ggacctggcc tggtggcgcc ctcacagagc 120 ctgtccatca
catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt 180
cgccagcctc caggaaaggg tctagagtgg ctgggaatga tatggggtga tggaagcaca
240 gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc
caagagccaa 300 gttttcttaa aaatgaacag tctgcaaact gatgacacag
ccagatacta ctgtgctcga 360 gatggttata gtaactttca ttactatgtt
atggactact ggggtcaagg aacctcagtc 420 accgtctcct ctgggggtgg
aggctctggt ggcggtggat ccggcggagg tgggtcgggt 480 ggcggcggat
ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt 540
cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta
600 atgcagtggt accaacagaa accaggacag ccacccaaac tcctcatctc
tgctgctagc 660 aacgtagaat ctggggtccc tgccaggttt agtggcagtg
ggtctgggac agactttagc 720 ctcaacatcc atcctgtgga ggaggatgat
attgcaatgt atttctgtca gcaaagtagg 780 aaggttccat ggacgttcgg
tggaggcacc aagctggaaa tcaaacgtga tcaggagccc 840 aaatcttctg
acaaaactca cacatcccca ccgtccccag cacctgaact cctgggggga 900
tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct
960 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa
gttcaactgg 1020 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc
cgcgggagga gcagtacaac 1080 agcacgtacc gtgtggtcag cgtcctcacc
gtcctgcacc aggactggct gaatggcaag 1140 gagtacaagt gcaaggtctc
caacaaagcc ctcccagcct ccatcgagaa aacaatctcc 1200 aaagccaaag
ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 1260
ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc
1320 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac
gcctcccgtg 1380 ctggactccg acggctcctt cttcctctac agcaagctca
ccgtggacaa gagcaggtgg 1440 cagcagggga acgtcttctc atgctccgtg
atgcatgagg ctctgcacaa ccactacacg 1500 cagaagagcc tctccctgtc
tccgggtaaa tga 1533 <210> SEQ ID NO 201 <211> LENGTH:
510 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: 2e12-sss-IgG1
HL SMIP (AA) <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1)..(22) <223> OTHER
INFORMATION: Leader <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (24)..(144) <223> OTHER
INFORMATION: VH <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (145)..(164) <223> OTHER
INFORMATION: Linker <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (165)..(276) <223> OTHER
INFORMATION: VL <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (279)..(293) <223> OTHER
INFORMATION: Hinge <400> SEQUENCE: 201 Met Asp Phe Gln Val
Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met
Ser Arg Gly Val Gln Val Gln Leu Lys Glu Ser Gly Pro 20 25 30 Gly
Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 35 40
45 Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro
50 55 60 Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly
Ser Thr 65 70 75 80 Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile
Thr Lys Asp Asn 85 90 95 Ser Lys Ser Gln Val Phe Leu Lys Met Asn
Ser Leu Gln Thr Asp Asp 100 105 110 Thr Ala Arg Tyr Tyr Cys Ala Arg
Asp Gly Tyr Ser Asn Phe His Tyr 115 120 125 Tyr Val Met Asp Tyr Trp
Gly Gln Gly Thr Ser Val Thr Val Ser Ser 130 135 140 Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 145 150 155 160 Gly
Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 165 170
175 Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser
180 185 190 Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln
Lys Pro 195 200 205 Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser
Asn Val Glu Ser 210 215 220 Gly Val Pro Ala Arg Phe Ser Gly Ser Gly
Ser Gly Thr Asp Phe Ser 225 230 235 240 Leu Asn Ile His Pro Val Glu
Glu Asp Asp Ile Ala Met Tyr Phe Cys 245 250 255 Gln Gln Ser Arg Lys
Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 260 265 270 Glu Ile Lys
Arg Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr 275 280 285 Ser
Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe 290 295
300 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
305 310 315 320 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
Pro Glu Val 325 330 335 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
His Asn Ala Lys Thr 340 345 350 Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr Arg Val Val Ser Val 355 360 365 Leu Thr Val Leu His Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys 370 375 380 Lys Val Ser Asn Lys
Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 385 390 395 400 Lys Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 405 410 415
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 420
425 430 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
Gly 435 440 445 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
Asp Ser Asp 450 455 460 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp 465 470 475 480 Gln Gln Gly Asn Val Phe Ser Cys
Ser Val Met His Glu Ala Leu His 485 490 495 Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser Pro Gly Lys 500 505 510 <210> SEQ ID NO
202
<211> LENGTH: 1518 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2e12-sss-IgG1 LH SMIP (DNA) <400>
SEQUENCE: 202 atggattttc aagtgcagat tttcagcttc ctgctaatca
gtgcttcagt cataatgtcc 60 agaggagtcg acattgtgct cacccaatct
ccagcttctt tggctgtgtc tctaggtcag 120 agagccacca tctcctgcag
agccagtgaa agtgttgaat attatgtcac aagtttaatg 180 cagtggtacc
aacagaaacc aggacagcca cccaaactcc tcatctctgc tgctagcaac 240
gtagaatctg gggtccctgc caggtttagt ggcagtgggt ctgggacaga ctttagcctc
300 aacatccatc ctgtggagga ggatgatatt gcaatgtatt tctgtcagca
aagtaggaag 360 gttccatgga cgttcggtgg aggcaccaag ctggaaatca
aacggggtgg cggtggatcc 420 ggcggaggtg ggtcgggtgg cggcggatct
caggtgcagc tgaaggagtc aggacctggc 480 ctggtggcgc cctcacagag
cctgtccatc acatgcaccg tctcagggtt ctcattaacc 540 ggctatggtg
taaactgggt tcgccagcct ccaggaaagg gtctagagtg gctgggaatg 600
atatggggtg atggaagcac agactataat tcagctctca aatccagact atcgatcacc
660 aaggacaact ccaagagcca agttttctta aaaatgaaca gtctgcaaac
tgatgacaca 720 gccagatact actgtgctcg agatggttat agtaactttc
attactatgt tatggactac 780 tggggtcaag gaacctcagt caccgtctcc
tctgatcagg agcccaaatc ttctgacaaa 840 actcacacat ccccaccgtc
cccagcacct gaactcctgg ggggaccgtc agtcttcctc 900 ttccccccaa
aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg 960
gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg
1020 gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac
gtaccgtgtg 1080 gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg
gcaaggagta caagtgcaag 1140 gtctccaaca aagccctccc agcccccatc
gagaaaacaa tctccaaagc caaagggcag 1200 ccccgagaac cacaggtgta
caccctgccc ccatcccggg atgagctgac caagaaccag 1260 gtcagcctga
cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag 1320
agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc
1380 tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca
ggggaacgtc 1440 ttctcatgct ccgtgatgca tgaggctctg cacaaccact
acacgcagaa gagcctctcc 1500 ctgtctccgg gtaaatga 1518 <210> SEQ
ID NO 203 <211> LENGTH: 505 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2e12-sss-IgG1 LH SMIP (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(23)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(24)..(135) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(136)..(150) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(151)..(271) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(274)..(288) <223> OTHER INFORMATION: Hinge <400>
SEQUENCE: 203 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile
Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Val Asp Ile Val Leu
Thr Gln Ser Pro Ala 20 25 30 Ser Leu Ala Val Ser Leu Gly Gln Arg
Ala Thr Ile Ser Cys Arg Ala 35 40 45 Ser Glu Ser Val Glu Tyr Tyr
Val Thr Ser Leu Met Gln Trp Tyr Gln 50 55 60 Gln Lys Pro Gly Gln
Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 65 70 75 80 Val Glu Ser
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 85 90 95 Asp
Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met 100 105
110 Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly
115 120 125 Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly
Gly Gly 130 135 140 Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu
Ser Gly Pro Gly 145 150 155 160 Leu Val Ala Pro Ser Gln Ser Leu Ser
Ile Thr Cys Thr Val Ser Gly 165 170 175 Phe Ser Leu Thr Gly Tyr Gly
Val Asn Trp Val Arg Gln Pro Pro Gly 180 185 190 Lys Gly Leu Glu Trp
Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp 195 200 205 Tyr Asn Ser
Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser 210 215 220 Lys
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 225 230
235 240 Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr
Tyr 245 250 255 Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val
Ser Ser Asp 260 265 270 Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr
Ser Pro Pro Ser Pro 275 280 285 Ala Pro Glu Leu Leu Gly Gly Pro Ser
Val Phe Leu Phe Pro Pro Lys 290 295 300 Pro Lys Asp Thr Leu Met Ile
Ser Arg Thr Pro Glu Val Thr Cys Val 305 310 315 320 Val Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 325 330 335 Val Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 340 345 350
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 355
360 365 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
Lys 370 375 380 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala
Lys Gly Gln 385 390 395 400 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Asp Glu Leu 405 410 415 Thr Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr Pro 420 425 430 Ser Asp Ile Ala Val Glu
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 435 440 445 Tyr Lys Thr Thr
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 450 455 460 Tyr Ser
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 465 470 475
480 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
485 490 495 Lys Ser Leu Ser Leu Ser Pro Gly Lys 500 505 <210>
SEQ ID NO 204 <211> LENGTH: 1498 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: G28-1 LH SMIP (DNA) <400>
SEQUENCE: 204 aagcttgccg ccatggaagc accagcgcag cttctcttcc
tcctgctact ctggctccca 60 gataccaccg gtgacatcca gatgactcag
tctccagcct ccctatctgc atctgtggga 120 gagactgtca ccatcacatg
tcgaacaagt gaaaatgttt acagttattt ggcttggtat 180 cagcagaaac
agggaaaatc tcctcagctc ctggtctctt ttgcaaaaac cttagcagaa 240
ggtgtgccat caaggttcag tggcagtgga tcaggcacac agttttctct gaagatcagc
300 agcctgcagc ctgaagattc tggaagttat ttctgtcaac atcattccga
taatccgtgg 360 acgttcggtg gaggcaccga actggagatc aaaggtggcg
gtggctcggg cggtggtggg 420 tcgggtggcg gcggatctgc tagcgcagtc
cagctgcagc agtctggacc tgagctggaa 480 aagcctggcg cttcagtgaa
gatttcctgc aaggcttctg gttactcatt cactggctac 540 aatatgaact
gggtgaagca gaataatgga aagagccttg agtggattgg aaatattgat 600
ccttattatg gtggtactac ctacaaccgg aagttcaagg gcaaggccac attgactgta
660 gacaaatcct ccagcacagc ctacatgcag ctcaagagtc tgacatctga
ggactctgca 720 gtctattact gtgcaagatc ggtcggccct atggactact
ggggtcaagg aacctcagtc 780 accgtctcga gcgagcccaa atcttctgac
aaaactcaca catgcccacc gtgcccagca 840 cctgaactcc tgggtggacc
gtcagtcttc ctcttccccc caaaacccaa ggacaccctc 900 atgatctccc
ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct 960
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg
1020 cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt
cctgcaccag 1080 gactggctga atggcaagga gtacaagtgc aaggtctcca
acaaagccct cccagccccc 1140 atcgagaaaa ccatctccaa agccaaaggg
cagccccgag aaccacaggt gtacaccctg 1200 cccccatccc gggatgagct
gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc 1260 ttctatccaa
gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac 1320
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc
1380 gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat
gcatgaggct 1440 ctgcacaacc actacacgca gaagagcctc tccctgtctc
cgggtaagtg actctaga 1498 <210> SEQ ID NO 205 <211>
LENGTH: 492 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence
<220> FEATURE: <223> OTHER INFORMATION: G28-1 LH SMIP
(AA) <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(20) <223> OTHER INFORMATION:
Leader <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (21)..(127) <223> OTHER INFORMATION: VL
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (128)..(144) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (145)..(260) <223> OTHER INFORMATION: VH
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (261)..(275) <223> OTHER INFORMATION: Hinge
<400> SEQUENCE: 205 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Asp Ile Gln Met
Thr Gln Ser Pro Ala Ser Leu Ser 20 25 30 Ala Ser Val Gly Glu Thr
Val Thr Ile Thr Cys Arg Thr Ser Glu Asn 35 40 45 Val Tyr Ser Tyr
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 50 55 60 Gln Leu
Leu Val Ser Phe Ala Lys Thr Leu Ala Glu Gly Val Pro Ser 65 70 75 80
Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Ser 85
90 95 Ser Leu Gln Pro Glu Asp Ser Gly Ser Tyr Phe Cys Gln His His
Ser 100 105 110 Asp Asn Pro Trp Thr Phe Gly Gly Gly Thr Glu Leu Glu
Ile Lys Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Ala Ser 130 135 140 Ala Val Gln Leu Gln Gln Ser Gly Pro
Glu Leu Glu Lys Pro Gly Ala 145 150 155 160 Ser Val Lys Ile Ser Cys
Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 165 170 175 Asn Met Asn Trp
Val Lys Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile 180 185 190 Gly Asn
Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr Asn Arg Lys Phe 195 200 205
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 210
215 220 Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr
Cys 225 230 235 240 Ala Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln
Gly Thr Ser Val 245 250 255 Thr Val Ser Ser Glu Pro Lys Ser Ser Asp
Lys Thr His Thr Cys Pro 260 265 270 Pro Cys Pro Ala Pro Glu Leu Leu
Gly Gly Pro Ser Val Phe Leu Phe 275 280 285 Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val 290 295 300 Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 305 310 315 320 Asn
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 325 330
335 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
340 345 350 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val 355 360 365 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala 370 375 380 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg 385 390 395 400 Asp Glu Leu Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu Val Lys Gly 405 410 415 Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 420 425 430 Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 435 440 445 Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 450 455
460 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
465 470 475 480 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485
490 <210> SEQ ID NO 206 <211> LENGTH: 1522 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: G28-1 HL SMIP (DNA)
<400> SEQUENCE: 206 aagcttgccg ccatggaagc accagcgcag
cttctcttcc tcctgctact ctggctccca 60 gataccaccg gtgcggtcca
gctgcagcag tctggacctg agtcggaaaa gcctggcgct 120 tcagtgaaga
tttcctgcaa ggcttctggt tactcattca ctggctacaa tatgaactgg 180
gtgaagcaga ataatggaaa gagccttgag tggattggaa atattgatcc ttattatggt
240 ggtactacct acaaccggaa gttcaagggc aaggccacat tgactgtaga
caaatcctcc 300 ggcacagcct acatgcagct caagagtctg acatctgagg
actctgcagt ctattactgt 360 gcaagatcgg tcggccctat ggactactgg
ggtcaaggaa cctcagtcac cgtctcttct 420 ggtggcggtg gctcgggcgg
tggtgggtcg ggtggcggcg gatcaggagg aggcgggagt 480 gctagcgaca
tccagatgac tcagtctcca gcctccctat ctgcatctgt gggagagact 540
gtcaccatca catgtcgaac aagtgaaaat gtttacagtt atttggcttg gtatcagcag
600 aaacagggaa aatctcctca gctcctggtc tcttttgcaa aaaccttagc
agaaggtgtg 660 ccatcaaggt tcagtggcag tggatcaggc acacagtttt
ctctgaagat cagcagcctg 720 cagcctgaag attctggaag ttatttctgt
caacatcatt ccgataatcc gtggacgttc 780 ggtggaggca ccgaactgga
gatcaaaggc tcgagcgagc ccaaatcttc tgacaaaact 840 cacacatgcc
caccgtgccc agcacctgaa ctcctgggtg gaccgtcagt cttcctcttc 900
cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg
960 gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga
cggcgtggag 1020 gtgcataatg ccaagacaaa gccgcgggag gagcagtaca
acagcacgta ccgtgtggtc 1080 agcgtcctca ccgtcctgca ccaggactgg
ctgaatggca aggagtacaa gtgcaaggtc 1140 tccaacaaag ccctcccagc
ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1200 cgagaaccac
aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc 1260
agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc
1320 aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc
cgacggctcc 1380 ttcttcctct acagcaagct caccgtggac aagagcaggt
ggcagcaggg gaacgtcttc 1440 tcatgctccg tgatgcatga ggctctgcac
aaccactaca cgcagaagag cctctccctg 1500 tctccgggta agtgactcta ga 1522
<210> SEQ ID NO 207 <211> LENGTH: 500 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: G28-1 HL SMIP (AA) <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1)..(20) <223> OTHER INFORMATION: Leader <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(21)..(136) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(137)..(158) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(159)..(266) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(283) <223> OTHER INFORMATION: Hinge <400>
SEQUENCE: 207 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Ala Val Gln Leu Gln Gln Ser
Gly Pro Glu Ser Glu 20 25 30 Lys Pro Gly Ala Ser Val Lys Ile Ser
Cys Lys Ala Ser Gly Tyr Ser 35 40 45 Phe Thr Gly Tyr Asn Met Asn
Trp Val Lys Gln Asn Asn Gly Lys Ser 50 55 60 Leu Glu Trp Ile Gly
Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Thr Tyr 65 70 75 80 Asn Arg Lys
Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 85 90 95 Gly
Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala 100 105
110 Val Tyr Tyr Cys Ala Arg Ser Val Gly Pro Met Asp Tyr Trp Gly Gln
115 120 125 Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly 130 135 140 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Ala Ser Asp Ile 145 150 155 160 Gln Met Thr Gln Ser Pro Ala Ser Leu
Ser Ala Ser Val Gly Glu Thr 165 170 175 Val Thr Ile Thr Cys Arg Thr
Ser Glu Asn Val Tyr Ser Tyr Leu Ala 180 185 190 Trp Tyr Gln Gln Lys
Gln Gly Lys Ser Pro Gln Leu Leu Val Ser Phe 195 200 205 Ala Lys Thr
Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 210 215 220
Ser Gly Thr Gln Phe Ser Leu Lys Ile Ser Ser Leu Gln Pro Glu Asp 225
230 235 240 Ser Gly Ser Tyr Phe Cys Gln His His Ser Asp Asn Pro Trp
Thr Phe 245 250 255 Gly Gly Gly Thr Glu Leu Glu Ile Lys Gly Ser Ser
Glu Pro Lys Ser 260 265 270 Ser Asp Lys Thr His Thr Cys Pro Pro Cys
Pro Ala Pro Glu Leu Leu 275 280 285 Gly Gly Pro Ser Val Phe Leu Phe
Pro Pro Lys Pro Lys Asp Thr Leu 290 295 300 Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val Val Asp Val Ser 305 310 315 320 His Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 325 330 335 Val
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 340 345
350 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
355 360 365 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
Ala Pro 370 375 380 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
Arg Glu Pro Gln 385 390 395 400 Val Tyr Thr Leu Pro Pro Ser Arg Asp
Glu Leu Thr Lys Asn Gln Val 405 410 415 Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val 420 425 430 Glu Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 435 440 445 Pro Val Leu
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 450 455 460 Val
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 465 470
475 480 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu 485 490 495 Ser Pro Gly Lys 500 <210> SEQ ID NO 208
<211> LENGTH: 1522 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: G19-4 LH SMIP (DNA) <400> SEQUENCE: 208
aagcttgccg ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca
60 gataccaccg gtgacatcca gatgacacag actacatcct ccctgtctgc
ctctctggga 120 gacagagtca ccatcagttg cagggcaagt caggacattc
gcaattattt aaactggtat 180 cagcagaaac cagatggaac tgttaaactc
ctgatctact acacatcaag attacactca 240 ggagtcccat caaggttcag
tggcagtggg tctggaacag attattctct caccattgcc 300 aacctgcaac
cagaagatat tgccacttac ttttgccaac agggtaatac gcttccgtgg 360
acgttcggtg gaggcaccaa actggtaacc aaacggggtg gcggtggctc gggcggtggt
420 ggatctggag gaggtgggag cgctagcgag gtccagctgc aacagtctgg
acctgaactg 480 gtgaagcctg gagcttcaat gaagatttcc tgcaaggcct
ctggttactc attcactggc 540 tacatcgtga actggctgaa gcagagccat
ggaaagaacc ttgagtggat tggacttatt 600 aatccataca aaggtcttac
tacctacaac cagaaattca agggcaaggc cacattaact 660 gtagacaagt
catccagcac agcctacatg gagctcctca gtctgacatc tgaagactct 720
gcagtctatt actgtgcaag atctgggtac tatggtgact cggactggta cttcgatgtc
780 tggggcgcag ggaccacggt caccgtctcc tcgagcgagc ccaaatcttc
tgacaaaact 840 cacacatgcc caccgtgccc agcacctgaa ctcctgggtg
gaccgtcagt cttcctcttc 900 cccccaaaac ccaaggacac cctcatgatc
tcccggaccc ctgaggtcac atgcgtggtg 960 gtggacgtga gccacgaaga
ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1020 gtgcataatg
ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1080
agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc
1140 tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa
agggcagccc 1200 cgagaaccac aggtgtacac cctgccccca tcccgggatg
agctgaccaa gaaccaggtc 1260 agcctgacct gcctggtcaa aggcttctat
ccaagcgaca tcgccgtgga gtgggagagc 1320 aatgggcagc cggagaacaa
ctacaagacc acgcctcccg tgctggactc cgacggctcc 1380 ttcttcctct
acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 1440
tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg
1500 tctccgggta agtgactcta ga 1522 <210> SEQ ID NO 209
<211> LENGTH: 500 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: G19-4 LH SMIP (AA) <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Leader <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (21)..(128)
<223> OTHER INFORMATION: VL <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (129)..(145)
<223> OTHER INFORMATION: Linker <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(146)..(267) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge <400>
SEQUENCE: 209 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Thr
Thr Ser Ser Leu Ser 20 25 30 Ala Ser Leu Gly Asp Arg Val Thr Ile
Ser Cys Arg Ala Ser Gln Asp 35 40 45 Ile Arg Asn Tyr Leu Asn Trp
Tyr Gln Gln Lys Pro Asp Gly Thr Val 50 55 60 Lys Leu Leu Ile Tyr
Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 65 70 75 80 Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ala 85 90 95 Asn
Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 100 105
110 Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Val Thr Lys Arg
115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ala 130 135 140 Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu
Val Lys Pro Gly 145 150 155 160 Ala Ser Met Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ser Phe Thr Gly 165 170 175 Tyr Ile Val Asn Trp Leu Lys
Gln Ser His Gly Lys Asn Leu Glu Trp 180 185 190 Ile Gly Leu Ile Asn
Pro Tyr Lys Gly Leu Thr Thr Tyr Asn Gln Lys 195 200 205 Phe Lys Gly
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 210 215 220 Tyr
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 225 230
235 240 Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp
Val 245 250 255 Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ser Glu
Pro Lys Ser 260 265 270 Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro
Ala Pro Glu Leu Leu 275 280 285 Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro Lys Asp Thr Leu 290 295 300 Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val Val Asp Val Ser 305 310 315 320 His Glu Asp Pro
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 325 330 335 Val His
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 340 345 350
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 355
360 365 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
Pro 370 375 380 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
Glu Pro Gln 385 390 395 400 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
Leu Thr Lys Asn Gln Val 405 410 415 Ser Leu Thr Cys Leu Val Lys Gly
Phe Tyr Pro Ser Asp Ile Ala Val 420 425 430 Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 435 440 445 Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 450 455 460 Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 465 470 475
480 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
485 490 495 Ser Pro Gly Lys 500 <210> SEQ ID NO 210
<211> LENGTH: 1525 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: G19-4 HL SMIP (DNA)
<400> SEQUENCE: 210 aagcttgccg ccatggaagc accagcgcag
cttctcttcc tcctgctact ctggctccca 60 gataccaccg gtgaggtcca
gctgcaacag tctggacctg aactggtgaa gcctggagct 120 tcaatgaaga
tttcctgcaa ggcctctggt tactcattca ctggctacat cgtgaactgg 180
ctgaagcaga gccatggaaa gaaccttgag tggattggac ttattaatcc atacaaaggt
240 cttactacct acaaccagaa attcaagggc aaggccacat tgactgtaga
caagtcatcc 300 agcacagcct acatggagct cctcagtctg acatctgaag
actctgcagt ctattactgt 360 gcaagatctg ggtactatgg tgactcagac
tggtacttcg atgtctgggg cgcagggacc 420 acagtcaccg tctcctctgg
cggcggtggc tcgggcggtg gtggatctgg aggaggtggg 480 agcgctagcg
acatccagat gacacagact acatcctccc tgtctgcctc tctgggagac 540
agagtcacca tcagttgcag ggcaagtcag gacattcgca attatttgaa ctggtatcag
600 cagaaaccag atggaactgt taaactcctg atctactaca catcaagact
acactcagga 660 gtcccatcaa ggttcagtgg cagtgggtct ggaacagatt
attctctcac cattgccaac 720 ctgcaaccag aagatattgc cacttacttt
tgccaacagg gtaatacact tccctggacg 780 ttcggtggag ggaccaaact
ggtgaccaaa cgctcgagcg agcccaaatc ttctgacaaa 840 actcacacat
gcccaccgtg cccagcacct gaactcctgg gtggaccgtc agtcttcctc 900
ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg
960 gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt
ggacggcgtg 1020 gaggtgcata atgccaagac aaagccgcgg gaggagcagt
acaacagcac gtaccgtgtg 1080 gtcagcgtcc tcaccgtcct gcaccaggac
tggctgaatg gcaaggagta caagtgcaag 1140 gtctccaaca aagccctccc
agcccccatc gagaaaacca tctccaaagc caaagggcag 1200 ccccgagaac
cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag 1260
gtcagcctga cctgcctggt caaaggcttc tatccaagcg acatcgccgt ggagtgggag
1320 agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga
ctccgacggc 1380 tccttcttcc tctacagcaa gctcaccgtg gacaagagca
ggtggcagca ggggaacgtc 1440 ttctcatgct ccgtgatgca tgaggctctg
cacaaccact acacgcagaa gagcctctcc 1500 ctgtctccgg gtaagtgact ctaga
1525 <210> SEQ ID NO 211 <211> LENGTH: 501 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: G19-4 HL SMIP (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(20) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (21)..(142) <223> OTHER INFORMATION: VH <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(159) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(160)..(267) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(270)..(284) <223> OTHER INFORMATION: Hinge <400>
SEQUENCE: 211 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu
Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Glu Val Gln Leu Gln Gln Ser
Gly Pro Glu Leu Val 20 25 30 Lys Pro Gly Ala Ser Met Lys Ile Ser
Cys Lys Ala Ser Gly Tyr Ser 35 40 45 Phe Thr Gly Tyr Ile Val Asn
Trp Leu Lys Gln Ser His Gly Lys Asn 50 55 60 Leu Glu Trp Ile Gly
Leu Ile Asn Pro Tyr Lys Gly Leu Thr Thr Tyr 65 70 75 80 Asn Gln Lys
Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 85 90 95 Ser
Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala 100 105
110 Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr
115 120 125 Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
Gly Gly 130 135 140 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Ala Ser Asp 145 150 155 160 Ile Gln Met Thr Gln Thr Thr Ser Ser
Leu Ser Ala Ser Leu Gly Asp 165 170 175 Arg Val Thr Ile Ser Cys Arg
Ala Ser Gln Asp Ile Arg Asn Tyr Leu 180 185 190 Asn Trp Tyr Gln Gln
Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 195 200 205 Tyr Thr Ser
Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 210 215 220 Gly
Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ala Asn Leu Gln Pro Glu 225 230
235 240 Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp
Thr 245 250 255 Phe Gly Gly Gly Thr Lys Leu Val Thr Lys Arg Ser Ser
Glu Pro Lys 260 265 270 Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys
Pro Ala Pro Glu Leu 275 280 285 Leu Gly Gly Pro Ser Val Phe Leu Phe
Pro Pro Lys Pro Lys Asp Thr 290 295 300 Leu Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val Val Asp Val 305 310 315 320 Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 325 330 335 Glu Val
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 340 345 350
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 355
360 365 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
Ala 370 375 380 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
Arg Glu Pro 385 390 395 400 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
Glu Leu Thr Lys Asn Gln 405 410 415 Val Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala 420 425 430 Val Glu Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 435 440 445 Pro Pro Val Leu
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 450 455 460 Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 465 470 475
480 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
485 490 495 Leu Ser Pro Gly Lys 500 <210> SEQ ID NO 212
<211> LENGTH: 2328 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: n2H7sssIgG1-STD1-2e12HL (DNA) <400>
SEQUENCE: 212 aagcttgccg ccatggaagc accagcgcag cttctcttcc
tcctgctact ctggctccca 60 gataccaccg gtcaaattgt tctctcccag
tctccagcaa tcctgtctgc atctccaggg 120 gagaaggtca caatgacttg
cagggccagc tcaagtgtaa gttacatgca ctggtaccag 180 cagaagccag
gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga 240
gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcaga
300 gtggaggctg aagatgctgc cacttattac tgccagcagt ggagttttaa
cccacccacg 360 ttcggtgctg ggaccaagct ggagctgaaa gatggcggtg
gctcgggcgg tggtggatct 420 ggaggaggtg gagctagcca ggcttatcta
cagcagtctg gggctgagct ggtgaggcct 480 ggggcctcag tgaagatgtc
ctgcaaggct tctggctaca catttaccag ttacaatatg 540 cactgggtaa
agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga 600
aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac tgtagacaaa
660 tcctccagca cagcctacat gcagctcagc agcctgacat ctgaagactc
tgcggtctat 720 ttctgtgcaa gagtggtgta ctatagtaac tcttactggt
acttcgatgt ctggggcaca 780 gggaccacgg tcaccgtctc gagcgagccc
aaatcttctg acaaaactca cacatcccca 840 ccgagcccag cacctgaact
cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 900 aaggacaccc
tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 960
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc
1020 aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag
cgtcctcacc 1080 gtcctgcacc aggactggct gaatggcaag gagtacaagt
gcaaggtctc caacaaagcc 1140 ctcccagccc ccatcgagaa aacaatctcc
aaagccaaag ggcagccccg agaaccacag 1200 gtgtacaccc tgcccccatc
ccgggatgag ctgaccaaga accaggtcag cctgacctgc 1260 ctggtcaaag
gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 1320
gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac
1380 agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc
atgctccgtg 1440 atgcatgagg ctctgcacaa ccactacacg cagaagagcc
tctccctgtc tccgggtaag 1500 aattatggtg gcggtggctc gggcggtggt
ggatctggag gaggtgggag tgggaattct 1560 caggtgcagc tgaaggagtc
aggacctggc ctggtggcgc cctcacagag cctgtccatc 1620 acatgcaccg
tctcagggtt ctcattaacc ggctatggtg taaactgggt tcgccagcct 1680
ccaggaaagg gtctggagtg gctgggaatg atatggggtg atggaagcac agactataat
1740 tcagctctca aatccagact atcgatcacc aaggacaact ccaagagcca
agttttctta 1800 aaaatgaaca gtctgcaaac tgatgacaca gccagatact
actgtgctcg agatggttat 1860
agtaactttc attactatgt tatggactac tggggtcaag gaacctcagt caccgtctcc
1920 tctgggggtg gaggctctgg tggcggtgga tccggcggag gtgggtcggg
tggcggcgga 1980 tctgacattg tgctcaccca atctccagct tctttggctg
tgtctctagg tcagagagcc 2040 accatctcct gcagagccag tgaaagtgtt
gaatattatg tcacaagttt aatgcagtgg 2100 taccaacaga aaccaggaca
gccacccaaa ctcctcatct ctgctgctag caacgtagaa 2160 tctggggtcc
ctgccaggtt tagtggcagt gggtctggga cagactttag cctcaacatc 2220
catcctgtgg aggaggatga tattgcaatg tatttctgtc agcaaagtag gaaggttcca
2280 tggacgttcg gtggaggcac caagctggaa atcaaacgtt aatctaga 2328
<210> SEQ ID NO 213 <211> LENGTH: 769 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: n2H7sssIgG1-STD1-2e12HL (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(20) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (21)..(127) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(128)..(142) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(516) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (517)..(637) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (638)..(657) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (658)..(769) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 213 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190 Ile Tyr
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 210
215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala
Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp
Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330
335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455
460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 495 Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly 500 505 510 Ser Gly Asn Ser Gln Val Gln Leu Lys
Glu Ser Gly Pro Gly Leu Val 515 520 525 Ala Pro Ser Gln Ser Leu Ser
Ile Thr Cys Thr Val Ser Gly Phe Ser 530 535 540 Leu Thr Gly Tyr Gly
Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly 545 550 555 560 Leu Glu
Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn 565 570 575
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser 580
585 590 Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala
Arg 595 600 605 Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr
Tyr Val Met 610 615 620 Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val
Ser Ser Gly Gly Gly 625 630 635 640 Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly 645 650 655 Ser Asp Ile Val Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu 660 665 670 Gly Gln Arg Ala
Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr 675 680 685 Tyr Val
Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro 690 695 700
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro 705
710 715 720 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu
Asn Ile 725 730 735 His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe
Cys Gln Gln Ser 740 745 750 Arg Lys Val Pro Trp Thr Phe Gly Gly Gly
Thr Lys Leu Glu Ile Lys 755 760 765 Arg <210> SEQ ID NO 214
<211> LENGTH: 2313 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: n2H7sssIgG1-STD2-2e12LH (DNA) <400>
SEQUENCE: 214 aagcttgccg ccatggaagc accagcgcag cttctcttcc
tcctgctact ctggctccca 60 gataccaccg gtcaaattgt tctctcccag
tctccagcaa tcctgtctgc atctccaggg 120 gagaaggtca caatgacttg
cagggccagc tcaagtgtaa gttacatgca ctggtaccag 180 cagaagccag
gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga 240
gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcaga
300 gtggaggctg aagatgctgc cacttattac tgccagcagt ggagttttaa
cccacccacg 360 ttcggtgctg ggaccaagct ggagctgaaa gatggcggtg
gctcgggcgg tggtggatct 420 ggaggaggtg gagctagcca ggcttatcta
cagcagtctg gggctgagct ggtgaggcct 480 ggggcctcag tgaagatgtc
ctgcaaggct tctggctaca catttaccag ttacaatatg 540 cactgggtaa
agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga 600
aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac tgtagacaaa
660 tcctccagca cagcctacat gcagctcagc agcctgacat ctgaagactc
tgcggtctat 720 ttctgtgcaa gagtggtgta ctatagtaac tcttactggt
acttcgatgt ctggggcaca 780 gggaccacgg tcaccgtctc gagcgagccc
aaatcttctg acaaaactca cacatcccca 840 ccgagcccag cacctgaact
cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 900 aaggacaccc
tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 960
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc
1020
aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc
1080 gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc
caacaaagcc 1140 ctcccagccc ccatcgagaa aacaatctcc aaagccaaag
ggcagccccg agaaccacag 1200 gtgtacaccc tgcccccatc ccgggatgag
ctgaccaaga accaggtcag cctgacctgc 1260 ctggtcaaag gcttctatcc
cagcgacatc gccgtggagt gggagagcaa tgggcagccg 1320 gagaacaact
acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac 1380
agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg
1440 atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc
tccgggtaag 1500 aattatggtg gcggtggctc gggcggtggt ggatctggag
gaggtgggag tgggaattct 1560 gacattgtgc tcacccaatc tccagcttct
ttggctgtgt ctctaggtca gagagccacc 1620 atctcctgca gagccagtga
aagtgttgaa tattatgtca caagtttaat gcagtggtac 1680 caacagaaac
caggacagcc acccaaactc ctcatctctg ctgctagcaa cgtagaatct 1740
ggggtccctg ccaggtttag tggcagtggg tctgggacag actttagcct caacatccat
1800 cctgtggagg aggatgatat tgcaatgtat ttctgtcagc aaagtaggaa
ggttccatgg 1860 acgttcggtg gaggcaccaa gctggaaatc aaacggggtg
gcggtggatc cggcggaggt 1920 gggtcgggtg gcggcggatc tcaggtgcag
ctgaaggagt caggacctgg cctggtggcg 1980 ccctcacaga gcctgtccat
cacatgcacc gtctcagggt tctcattaac cggctatggt 2040 gtaaactggg
ttcgccagcc tccaggaaag ggtctggagt ggctgggaat gatatggggt 2100
gatggaagca cagactataa ttcagctctc aaatccagac tatcgatcac caaggacaac
2160 tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac
agccagatac 2220 tactgtgctc gagatggtta tagtaacttt cattactatg
ttatggacta ctggggtcaa 2280 ggaacctcag tcaccgtctc ctcttaatct aga
2313 <210> SEQ ID NO 215 <211> LENGTH: 764 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: n2H7sssIgG1-STD2-2e12LH
(AA) <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(20) <223> OTHER INFORMATION:
Leader <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (21)..(126) <223> OTHER INFORMATION: VL
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (127)..(142) <223> OTHER INFORMATION: Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (143)..(264) <223> OTHER INFORMATION: VH
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (265)..(279) <223> OTHER INFORMATION: Hinge
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (497)..(516) <223> OTHER INFORMATION: EFD-BD2
Linker <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (517)..(628) <223> OTHER INFORMATION:
VL2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (629)..(643) <223> OTHER INFORMATION:
Linker <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (644)..(764) <223> OTHER INFORMATION:
VH2 <400> SEQUENCE: 215 Met Glu Ala Pro Ala Gln Leu Leu Phe
Leu Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val
Leu Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu
Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr
Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro
Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70
75 80 Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser
Arg 85 90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
Trp Ser Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala
Glu Leu Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp
Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195
200 205 Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met
Gln 210 215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys Ala Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser
Glu Pro Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315
320 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
325 330 335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
Val Val 340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
Gly Lys Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
Ala Pro Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro
Arg Glu Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440
445 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
450 455 460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
Glu Ala 465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser Pro Gly Lys 485 490 495 Asn Tyr Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly 500 505 510 Ser Gly Asn Ser Asp Ile Val
Leu Thr Gln Ser Pro Ala Ser Leu Ala 515 520 525 Val Ser Leu Gly Gln
Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 530 535 540 Val Glu Tyr
Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 545 550 555 560
Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser 565
570 575 Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
Ser 580 585 590 Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met
Tyr Phe Cys 595 600 605 Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly
Gly Gly Thr Lys Leu 610 615 620 Glu Ile Lys Arg Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly 625 630 635 640 Gly Gly Ser Gln Val Gln
Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 645 650 655 Pro Ser Gln Ser
Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 660 665 670 Thr Gly
Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 675 680 685
Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser 690
695 700 Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser
Gln 705 710 715 720 Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp
Thr Ala Arg Tyr 725 730 735 Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe
His Tyr Tyr Val Met Asp 740 745 750 Tyr Trp Gly Gln Gly Thr Ser Val
Thr Val Ser Ser 755 760 <210> SEQ ID NO 216 <211>
LENGTH: 2048 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
n2H7sssIgG1-H1-2e12HL (DNA) <400> SEQUENCE: 216 aagcttgccg
ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca 60
gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg
120 gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca
ctggtaccag 180
cagaagccag gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga
240 gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac
aatcagcaga 300 gtggaggctg aagatgctgc cacttattac tgccagcagt
ggagttttaa cccacccacg 360 ttcggtgctg ggaccaagct ggagctgaaa
gatggcggtg gctcgggcgg tggtggatct 420 ggaggaggtg gagctagcca
ggcttatcta cagcagtctg gggctgagct ggtgaggcct 480 ggggcctcag
tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg 540
cactgggtaa agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga
600 aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac
tgtagacaaa 660 tcctccagca cagcctacat gcagctcagc agcctgacat
ctgaagactc tgcggtctat 720 ttctgtgcaa gagtggtgta ctatagtaac
tcttactggt acttcgatgt ctggggcaca 780 gggaccacgg tcaccgtctc
gagcgagccc aaatcttctg acaaaactca cacatcccca 840 ccgagcccag
cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 900
aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc
960 cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt
gcataatgcc 1020 aagacaaagc cgcgggagga gcagtacaac agcacgtacc
gtgtggtcag cgtcctcacc 1080 gtcctgcacc aggactggct gaatggcaag
gagtacaagt gcaaggtctc caacaaagcc 1140 ctcccagccc ccatcgagaa
aacaatctcc aaagccaaag ggcagccccg agaaccacag 1200 gtgtacaccc
tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc 1260
ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg
1320 gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt
cttcctctac 1380 agcaagctca ccgtggacaa gagcaggtgg cagcagggga
acgtcttctc atgctccgtg 1440 atgcatgagg ctctgcacaa ccactacacg
cagaagagcc tctccctgtc tccgggtaag 1500 aattctcagg tgcagctgaa
ggagtcagga cctggcctgg tggcgccctc acagagcctg 1560 tccatcacat
gcaccgtctc agggttctca ttaaccggct atggtgtaaa ctgggttcgc 1620
cagcctccag gaaagggtct ggagtggctg ggaatgatat ggggtgatgg aagcacagac
1680 tataattcag ctctcaaatc cagactatcg atcaccaagg acaactccaa
gagccaagtt 1740 ttcttaaaaa tgaacagtct gcaaactgat gacacagcca
gatactactg tgctcgagat 1800 ggttatagta actttcatta ctatgttatg
gactactggg gtcaaggaac ctcagtcacc 1860 gtctcctctg ggggtggagg
ctctggtggc ggtggatccg gcggaggtgg gtcgggtggc 1920 ggcggatctg
acattgtgct cacccaatct ccagcttctt tggctgtgtc tctaggtcag 1980
agagccacca tctcctgcag agccagtgaa agtgttgaat attatgtcac aagtttaatg
2040 cagtggta 2048 <210> SEQ ID NO 217 <211> LENGTH:
751 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION:
n2H7sssIgG1-H1-2e12HL (AA) <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Leader <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (21)..(126)
<223> OTHER INFORMATION: VL <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (127)..(142)
<223> OTHER INFORMATION: Linker <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(498) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (499)..(619) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (620)..(639) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (640)..(751) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 217 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190 Ile Tyr
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 210
215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala
Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp
Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330
335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455
460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 495 Asn Ser Gln Val Gln Leu Lys Glu Ser Gly Pro
Gly Leu Val Ala Pro 500 505 510 Ser Gln Ser Leu Ser Ile Thr Cys Thr
Val Ser Gly Phe Ser Leu Thr 515 520 525 Gly Tyr Gly Val Asn Trp Val
Arg Gln Pro Pro Gly Lys Gly Leu Glu 530 535 540 Trp Leu Gly Met Ile
Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala 545 550 555 560 Leu Lys
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val 565 570 575
Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr 580
585 590 Cys Ala Arg Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met Asp
Tyr 595 600 605 Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly
Gly Gly Ser 610 615 620 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Asp 625 630 635 640 Ile Val Leu Thr Gln Ser Pro Ala
Ser Leu Ala Val Ser Leu Gly Gln 645 650 655 Arg Ala Thr Ile Ser Cys
Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val 660 665 670 Thr Ser Leu Met
Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 675 680 685 Leu Leu
Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg 690 695 700
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro 705
710 715 720 Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser
Arg Lys 725 730 735 Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu
Ile Lys Arg 740 745 750
<210> SEQ ID NO 218 <211> LENGTH: 2292 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: n2H7sssIgG1-H2-2e12HL (DNA)
<400> SEQUENCE: 218 aagcttgccg ccatggaagc accagcgcag
cttctcttcc tcctgctact ctggctccca 60 gataccaccg gtcaaattgt
tctctcccag tctccagcaa tcctgtctgc atctccaggg 120 gagaaggtca
caatgacttg cagggccagc tcaagtgtaa gttacatgca ctggtaccag 180
cagaagccag gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga
240 gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac
aatcagcaga 300 gtggaggctg aagatgctgc cacttattac tgccagcagt
ggagttttaa cccacccacg 360 ttcggtgctg ggaccaagct ggagctgaaa
gatggcggtg gctcgggcgg tggtggatct 420 ggaggaggtg gagctagcca
ggcttatcta cagcagtctg gggctgagct ggtgaggcct 480 ggggcctcag
tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg 540
cactgggtaa agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga
600 aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac
tgtagacaaa 660 tcctccagca cagcctacat gcagctcagc agcctgacat
ctgaagactc tgcggtctat 720 ttctgtgcaa gagtggtgta ctatagtaac
tcttactggt acttcgatgt ctggggcaca 780 gggaccacgg tcaccgtctc
gagcgagccc aaatcttctg acaaaactca cacatcccca 840 ccgagcccag
cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 900
aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc
960 cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt
gcataatgcc 1020 aagacaaagc cgcgggagga gcagtacaac agcacgtacc
gtgtggtcag cgtcctcacc 1080 gtcctgcacc aggactggct gaatggcaag
gagtacaagt gcaaggtctc caacaaagcc 1140 ctcccagccc ccatcgagaa
aacaatctcc aaagccaaag ggcagccccg agaaccacag 1200 gtgtacaccc
tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc 1260
ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg
1320 gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt
cttcctctac 1380 agcaagctca ccgtggacaa gagcaggtgg cagcagggga
acgtcttctc atgctccgtg 1440 atgcatgagg ctctgcacaa ccactacacg
cagaagagcc tctccctgtc tccgggtaag 1500 ggtggcggtg gctcggggaa
ttctcaggtg cagctgaagg agtcaggacc tggcctggtg 1560 gcgccctcac
agagcctgtc catcacatgc accgtctcag ggttctcatt aaccggctat 1620
ggtgtaaact gggttcgcca gcctccagga aagggtctgg agtggctggg aatgatatgg
1680 ggtgatggaa gcacagacta taattcagct ctcaaatcca gactatcgat
caccaaggac 1740 aactccaaga gccaagtttt cttaaaaatg aacagtctgc
aaactgatga cacagccaga 1800 tactactgtg ctcgagatgg ttatagtaac
tttcattact atgttatgga ctactggggt 1860 caaggaacct cagtcaccgt
ctcctctggg ggtggaggct ctggtggcgg tggatccggc 1920 ggaggtgggt
cgggtggcgg cggatctgac attgtgctca cccaatctcc agcttctttg 1980
gctgtgtctc taggtcagag agccaccatc tcctgcagag ccagtgaaag tgttgaatat
2040 tatgtcacaa gtttaatgca gtggtaccaa cagaaaccag gacagccacc
caaactcctc 2100 atctctgctg ctagcaacgt agaatctggg gtccctgcca
ggtttagtgg cagtgggtct 2160 gggacagact ttagcctcaa catccatcct
gtggaggagg atgatattgc aatgtatttc 2220 tgtcagcaaa gtaggaaggt
tccatggacg ttcggtggag gcaccaagct ggaaatcaaa 2280 cgttaatcta ga 2292
<210> SEQ ID NO 219 <211> LENGTH: 757 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: n2H7sssIgG1-H2-2e12HL (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(20) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (21)..(126) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(127)..(142) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(504) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (505)..(625) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (626)..(645) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (646)..(757) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 219 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190 Ile Tyr
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 210
215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala
Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp
Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330
335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455
460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly Lys 485 490 495 Gly Gly Gly Gly Ser Gly Asn Ser Gln Val Gln
Leu Lys Glu Ser Gly 500 505 510 Pro Gly Leu Val Ala Pro Ser Gln Ser
Leu Ser Ile Thr Cys Thr Val 515 520 525 Ser Gly Phe Ser Leu Thr Gly
Tyr Gly Val Asn Trp Val Arg Gln Pro 530 535 540 Pro Gly Lys Gly Leu
Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser 545 550 555 560 Thr Asp
Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp 565 570 575
Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp 580
585 590 Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn Phe
His 595 600 605 Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
Thr Val Ser 610 615 620
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 625
630 635 640 Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala
Ser Leu 645 650 655 Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys
Arg Ala Ser Glu 660 665 670 Ser Val Glu Tyr Tyr Val Thr Ser Leu Met
Gln Trp Tyr Gln Gln Lys 675 680 685 Pro Gly Gln Pro Pro Lys Leu Leu
Ile Ser Ala Ala Ser Asn Val Glu 690 695 700 Ser Gly Val Pro Ala Arg
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 705 710 715 720 Ser Leu Asn
Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe 725 730 735 Cys
Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 740 745
750 Leu Glu Ile Lys Arg 755 <210> SEQ ID NO 220 <211>
LENGTH: 2298 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
n2H7sssIgG1-H3-2e12HL (DNA) <400> SEQUENCE: 220 aagcttgccg
ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca 60
gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg
120 gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca
ctggtaccag 180 cagaagccag gatcctcccc caaaccctgg atttatgccc
catccaacct ggcttctgga 240 gtccctgctc gcttcagtgg cagtgggtct
gggacctctt actctctcac aatcagcaga 300 gtggaggctg aagatgctgc
cacttattac tgccagcagt ggagttttaa cccacccacg 360 ttcggtgctg
ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct 420
ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct
480 ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag
ttacaatatg 540 cactgggtaa agcagacacc tagacagggc ctggaatgga
ttggagctat ttatccagga 600 aatggtgata cttcctacaa tcagaagttc
aagggcaagg ccacactgac tgtagacaaa 660 tcctccagca cagcctacat
gcagctcagc agcctgacat ctgaagactc tgcggtctat 720 ttctgtgcaa
gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca 780
gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca
840 ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc
cccaaaaccc 900 aaggacaccc tcatgatctc ccggacccct gaggtcacat
gcgtggtggt ggacgtgagc 960 cacgaagacc ctgaggtcaa gttcaactgg
tacgtggacg gcgtggaggt gcataatgcc 1020 aagacaaagc cgcgggagga
gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 1080 gtcctgcacc
aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 1140
ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag
1200 gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag
cctgacctgc 1260 ctggtcaaag gcttctatcc cagcgacatc gccgtggagt
gggagagcaa tgggcagccg 1320 gagaacaact acaagaccac gcctcccgtg
ctggactccg acggctcctt cttcctctac 1380 agcaagctca ccgtggacaa
gagcaggtgg cagcagggga acgtcttctc atgctccgtg 1440 atgcatgagg
ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag 1500
aattatggtg gcggtggctc tgggaattct caggtgcagc tgaaggagtc aggacctggc
1560 ctggtggcgc cctcacagag cctgtccatc acatgcaccg tctcagggtt
ctcattaacc 1620 ggctatggtg taaactgggt tcgccagcct ccaggaaagg
gtctggagtg gctgggaatg 1680 atatggggtg atggaagcac agactataat
tcagctctca aatccagact atcgatcacc 1740 aaggacaact ccaagagcca
agttttctta aaaatgaaca gtctgcaaac tgatgacaca 1800 gccagatact
actgtgctcg agatggttat agtaactttc attactatgt tatggactac 1860
tggggtcaag gaacctcagt caccgtctcc tctgggggtg gaggctctgg tggcggtgga
1920 tccggcggag gtgggtcggg tggcggcgga tctgacattg tgctcaccca
atctccagct 1980 tctttggctg tgtctctagg tcagagagcc accatctcct
gcagagccag tgaaagtgtt 2040 gaatattatg tcacaagttt aatgcagtgg
taccaacaga aaccaggaca gccacccaaa 2100 ctcctcatct ctgctgctag
caacgtagaa tctggggtcc ctgccaggtt tagtggcagt 2160 gggtctggga
cagactttag cctcaacatc catcctgtgg aggaggatga tattgcaatg 2220
tatttctgtc agcaaagtag gaaggttcca tggacgttcg gtggaggcac caagctggaa
2280 atcaaacgtt aatctaga 2298 <210> SEQ ID NO 221 <211>
LENGTH: 759 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
n2H7sssIgG1-H3-2e12HL (AA) <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1)..(20) <223>
OTHER INFORMATION: Leader <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (21)..(126)
<223> OTHER INFORMATION: VL <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (127)..(142)
<223> OTHER INFORMATION: Linker <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(506) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (507)..(627) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (628)..(647) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (648)..(759) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 221 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190 Ile Tyr
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 210
215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala
Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp
Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330
335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu
Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455
460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
465 470 475 480
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 485
490 495 Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser Gln Val Gln Leu Lys
Glu 500 505 510 Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
Ile Thr Cys 515 520 525 Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly
Val Asn Trp Val Arg 530 535 540 Gln Pro Pro Gly Lys Gly Leu Glu Trp
Leu Gly Met Ile Trp Gly Asp 545 550 555 560 Gly Ser Thr Asp Tyr Asn
Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr 565 570 575 Lys Asp Asn Ser
Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 580 585 590 Thr Asp
Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr Ser Asn 595 600 605
Phe His Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 610
615 620 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
Gly 625 630 635 640 Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr
Gln Ser Pro Ala 645 650 655 Ser Leu Ala Val Ser Leu Gly Gln Arg Ala
Thr Ile Ser Cys Arg Ala 660 665 670 Ser Glu Ser Val Glu Tyr Tyr Val
Thr Ser Leu Met Gln Trp Tyr Gln 675 680 685 Gln Lys Pro Gly Gln Pro
Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn 690 695 700 Val Glu Ser Gly
Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 705 710 715 720 Asp
Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met 725 730
735 Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly
740 745 750 Thr Lys Leu Glu Ile Lys Arg 755 <210> SEQ ID NO
222 <211> LENGTH: 2307 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: n2H7sssIgG1-H4-2e12HL (DNA) <400>
SEQUENCE: 222 aagcttgccg ccatggaagc accagcgcag cttctcttcc
tcctgctact ctggctccca 60 gataccaccg gtcaaattgt tctctcccag
tctccagcaa tcctgtctgc atctccaggg 120 gagaaggtca caatgacttg
cagggccagc tcaagtgtaa gttacatgca ctggtaccag 180 cagaagccag
gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga 240
gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcaga
300 gtggaggctg aagatgctgc cacttattac tgccagcagt ggagttttaa
cccacccacg 360 ttcggtgctg ggaccaagct ggagctgaaa gatggcggtg
gctcgggcgg tggtggatct 420 ggaggaggtg gagctagcca ggcttatcta
cagcagtctg gggctgagct ggtgaggcct 480 ggggcctcag tgaagatgtc
ctgcaaggct tctggctaca catttaccag ttacaatatg 540 cactgggtaa
agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga 600
aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac tgtagacaaa
660 tcctccagca cagcctacat gcagctcagc agcctgacat ctgaagactc
tgcggtctat 720 ttctgtgcaa gagtggtgta ctatagtaac tcttactggt
acttcgatgt ctggggcaca 780 gggaccacgg tcaccgtctc gagcgagccc
aaatcttctg acaaaactca cacatcccca 840 ccgagcccag cacctgaact
cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 900 aaggacaccc
tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 960
cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc
1020 aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag
cgtcctcacc 1080 gtcctgcacc aggactggct gaatggcaag gagtacaagt
gcaaggtctc caacaaagcc 1140 ctcccagccc ccatcgagaa aacaatctcc
aaagccaaag ggcagccccg agaaccacag 1200 gtgtacaccc tgcccccatc
ccgggatgag ctgaccaaga accaggtcag cctgacctgc 1260 ctggtcaaag
gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 1320
gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac
1380 agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc
atgctccgtg 1440 atgcatgagg ctctgcacaa ccactacacg cagaagagcc
tctccctgtc tccgggtaag 1500 ggtggcggtg gctcgggcgg tggtggatct
gggaattctc aggtgcagct gaaggagtca 1560 ggacctggcc tggtggcgcc
ctcacagagc ctgtccatca catgcaccgt ctcagggttc 1620 tcattaaccg
gctatggtgt aaactgggtt cgccagcctc caggaaaggg tctggagtgg 1680
ctgggaatga tatggggtga tggaagcaca gactataatt cagctctcaa atccagacta
1740 tcgatcacca aggacaactc caagagccaa gttttcttaa aaatgaacag
tctgcaaact 1800 gatgacacag ccagatacta ctgtgctcga gatggttata
gtaactttca ttactatgtt 1860 atggactact ggggtcaagg aacctcagtc
accgtctcct ctgggggtgg aggctctggt 1920 ggcggtggat ccggcggagg
tgggtcgggt ggcggcggat ctgacattgt gctcacccaa 1980 tctccagctt
ctttggctgt gtctctaggt cagagagcca ccatctcctg cagagccagt 2040
gaaagtgttg aatattatgt cacaagttta atgcagtggt accaacagaa accaggacag
2100 ccacccaaac tcctcatctc tgctgctagc aacgtagaat ctggggtccc
tgccaggttt 2160 agtggcagtg ggtctgggac agactttagc ctcaacatcc
atcctgtgga ggaggatgat 2220 attgcaatgt atttctgtca gcaaagtagg
aaggttccat ggacgttcgg tggaggcacc 2280 aagctggaaa tcaaacgtta atctaga
2307 <210> SEQ ID NO 223 <211> LENGTH: 762 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: n2H7sssIgG1-H4-2e12HL (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(20) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (21)..(126) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(127)..(142) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(509) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (510)..(630) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (631)..(650) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (651)..(762) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 223 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190 Ile Tyr
Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 210
215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala
Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp
Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser Glu Pro
Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser Pro Ala
Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315 320 Glu
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 325 330
335
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 340
345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp Glu Leu Thr
Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440 445 Ser Asp
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 450 455 460
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 465
470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 485 490 495 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn
Ser Gln Val Gln 500 505 510 Leu Lys Glu Ser Gly Pro Gly Leu Val Ala
Pro Ser Gln Ser Leu Ser 515 520 525 Ile Thr Cys Thr Val Ser Gly Phe
Ser Leu Thr Gly Tyr Gly Val Asn 530 535 540 Trp Val Arg Gln Pro Pro
Gly Lys Gly Leu Glu Trp Leu Gly Met Ile 545 550 555 560 Trp Gly Asp
Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu 565 570 575 Ser
Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 580 585
590 Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly
595 600 605 Tyr Ser Asn Phe His Tyr Tyr Val Met Asp Tyr Trp Gly Gln
Gly Thr 610 615 620 Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser 625 630 635 640 Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Asp Ile Val Leu Thr Gln 645 650 655 Ser Pro Ala Ser Leu Ala Val
Ser Leu Gly Gln Arg Ala Thr Ile Ser 660 665 670 Cys Arg Ala Ser Glu
Ser Val Glu Tyr Tyr Val Thr Ser Leu Met Gln 675 680 685 Trp Tyr Gln
Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala 690 695 700 Ala
Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 705 710
715 720 Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp
Asp 725 730 735 Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Lys Val Pro
Trp Thr Phe 740 745 750 Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 755
760 <210> SEQ ID NO 224 <211> LENGTH: 2313 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: n2H7sssIgG1-H5-2e12HL (DNA)
<400> SEQUENCE: 224 aagcttgccg ccatggaagc accagcgcag
cttctcttcc tcctgctact ctggctccca 60 gataccaccg gtcaaattgt
tctctcccag tctccagcaa tcctgtctgc atctccaggg 120 gagaaggtca
caatgacttg cagggccagc tcaagtgtaa gttacatgca ctggtaccag 180
cagaagccag gatcctcccc caaaccctgg atttatgccc catccaacct ggcttctgga
240 gtccctgctc gcttcagtgg cagtgggtct gggacctctt actctctcac
aatcagcaga 300 gtggaggctg aagatgctgc cacttattac tgccagcagt
ggagttttaa cccacccacg 360 ttcggtgctg ggaccaagct ggagctgaaa
gatggcggtg gctcgggcgg tggtggatct 420 ggaggaggtg gagctagcca
ggcttatcta cagcagtctg gggctgagct ggtgaggcct 480 ggggcctcag
tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg 540
cactgggtaa agcagacacc tagacagggc ctggaatgga ttggagctat ttatccagga
600 aatggtgata cttcctacaa tcagaagttc aagggcaagg ccacactgac
tgtagacaaa 660 tcctccagca cagcctacat gcagctcagc agcctgacat
ctgaagactc tgcggtctat 720 ttctgtgcaa gagtggtgta ctatagtaac
tcttactggt acttcgatgt ctggggcaca 780 gggaccacgg tcaccgtctc
gagcgagccc aaatcttctg acaaaactca cacatcccca 840 ccgagcccag
cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 900
aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc
960 cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt
gcataatgcc 1020 aagacaaagc cgcgggagga gcagtacaac agcacgtacc
gtgtggtcag cgtcctcacc 1080 gtcctgcacc aggactggct gaatggcaag
gagtacaagt gcaaggtctc caacaaagcc 1140 ctcccagccc ccatcgagaa
aacaatctcc aaagccaaag ggcagccccg agaaccacag 1200 gtgtacaccc
tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc 1260
ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg
1320 gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt
cttcctctac 1380 agcaagctca ccgtggacaa gagcaggtgg cagcagggga
acgtcttctc atgctccgtg 1440 atgcatgagg ctctgcacaa ccactacacg
cagaagagcc tctccctgtc tccgggtaag 1500 aattatggtg gcggtggctc
gggcggtggt ggatctggga attctcaggt gcagctgaag 1560 gagtcaggac
ctggcctggt ggcgccctca cagagcctgt ccatcacatg caccgtctca 1620
gggttctcat taaccggcta tggtgtaaac tgggttcgcc agcctccagg aaagggtctg
1680 gagtggctgg gaatgatatg gggtgatgga agcacagact ataattcagc
tctcaaatcc 1740 agactatcga tcaccaagga caactccaag agccaagttt
tcttaaaaat gaacagtctg 1800 caaactgatg acacagccag atactactgt
gctcgagatg gttatagtaa ctttcattac 1860 tatgttatgg actactgggg
tcaaggaacc tcagtcaccg tctcctctgg gggtggaggc 1920 tctggtggcg
gtggatccgg cggaggtggg tcgggtggcg gcggatctga cattgtgctc 1980
acccaatctc cagcttcttt ggctgtgtct ctaggtcaga gagccaccat ctcctgcaga
2040 gccagtgaaa gtgttgaata ttatgtcaca agtttaatgc agtggtacca
acagaaacca 2100 ggacagccac ccaaactcct catctctgct gctagcaacg
tagaatctgg ggtccctgcc 2160 aggtttagtg gcagtgggtc tgggacagac
tttagcctca acatccatcc tgtggaggag 2220 gatgatattg caatgtattt
ctgtcagcaa agtaggaagg ttccatggac gttcggtgga 2280 ggcaccaagc
tggaaatcaa acgttaatct aga 2313 <210> SEQ ID NO 225
<211> LENGTH: 764 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: n2H7sssIgG1-H5-2e12HL (AA) <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION: (1)..(20)
<223> OTHER INFORMATION: Leader <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(21)..(126) <223> OTHER INFORMATION: VL <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(127)..(142) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(511) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (512)..(632) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (633)..(652) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (653)..(764) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 225 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45 Val Ser Tyr Met
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50 55 60 Pro Trp
Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 65 70 75 80
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 85
90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser
Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser Gly Ala Glu Leu
Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175 His Trp Val Lys
Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180 185 190
Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 195
200 205 Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met
Gln 210 215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
Cys Ala Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val Ser Ser
Glu Pro Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro Pro Ser
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe Leu Phe
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300 Thr Pro
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305 310 315
320 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
325 330 335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
Val Val 340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
Gly Lys Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
Ala Pro Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly Gln Pro
Arg Glu Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser Arg Asp
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425 430 Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 435 440
445 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
450 455 460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
Glu Ala 465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser Pro Gly Lys 485 490 495 Asn Tyr Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Asn Ser Gln 500 505 510 Val Gln Leu Lys Glu Ser Gly
Pro Gly Leu Val Ala Pro Ser Gln Ser 515 520 525 Leu Ser Ile Thr Cys
Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Gly 530 535 540 Val Asn Trp
Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 545 550 555 560
Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser 565
570 575 Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
Lys 580 585 590 Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr
Cys Ala Arg 595 600 605 Asp Gly Tyr Ser Asn Phe His Tyr Tyr Val Met
Asp Tyr Trp Gly Gln 610 615 620 Gly Thr Ser Val Thr Val Ser Ser Gly
Gly Gly Gly Ser Gly Gly Gly 625 630 635 640 Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 645 650 655 Thr Gln Ser Pro
Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr 660 665 670 Ile Ser
Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu 675 680 685
Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 690
695 700 Ser Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser
Gly 705 710 715 720 Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His
Pro Val Glu Glu 725 730 735 Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln
Ser Arg Lys Val Pro Trp 740 745 750 Thr Phe Gly Gly Gly Thr Lys Leu
Glu Ile Lys Arg 755 760 <210> SEQ ID NO 226 <211>
LENGTH: 2322 <212> TYPE: DNA <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
n2H7sssIgG1-H6-2e12HL (DNA) <400> SEQUENCE: 226 aagcttgccg
ccatggaagc accagcgcag cttctcttcc tcctgctact ctggctccca 60
gataccaccg gtcaaattgt tctctcccag tctccagcaa tcctgtctgc atctccaggg
120 gagaaggtca caatgacttg cagggccagc tcaagtgtaa gttacatgca
ctggtaccag 180 cagaagccag gatcctcccc caaaccctgg atttatgccc
catccaacct ggcttctgga 240 gtccctgctc gcttcagtgg cagtgggtct
gggacctctt actctctcac aatcagcaga 300 gtggaggctg aagatgctgc
cacttattac tgccagcagt ggagttttaa cccacccacg 360 ttcggtgctg
ggaccaagct ggagctgaaa gatggcggtg gctcgggcgg tggtggatct 420
ggaggaggtg gagctagcca ggcttatcta cagcagtctg gggctgagct ggtgaggcct
480 ggggcctcag tgaagatgtc ctgcaaggct tctggctaca catttaccag
ttacaatatg 540 cactgggtaa agcagacacc tagacagggc ctggaatgga
ttggagctat ttatccagga 600 aatggtgata cttcctacaa tcagaagttc
aagggcaagg ccacactgac tgtagacaaa 660 tcctccagca cagcctacat
gcagctcagc agcctgacat ctgaagactc tgcggtctat 720 ttctgtgcaa
gagtggtgta ctatagtaac tcttactggt acttcgatgt ctggggcaca 780
gggaccacgg tcaccgtctc gagcgagccc aaatcttctg acaaaactca cacatcccca
840 ccgagcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc
cccaaaaccc 900 aaggacaccc tcatgatctc ccggacccct gaggtcacat
gcgtggtggt ggacgtgagc 960 cacgaagacc ctgaggtcaa gttcaactgg
tacgtggacg gcgtggaggt gcataatgcc 1020 aagacaaagc cgcgggagga
gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc 1080 gtcctgcacc
aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc 1140
ctcccagccc ccatcgagaa aacaatctcc aaagccaaag ggcagccccg agaaccacag
1200 gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag
cctgacctgc 1260 ctggtcaaag gcttctatcc cagcgacatc gccgtggagt
gggagagcaa tgggcagccg 1320 gagaacaact acaagaccac gcctcccgtg
ctggactccg acggctcctt cttcctctac 1380 agcaagctca ccgtggacaa
gagcaggtgg cagcagggga acgtcttctc atgctccgtg 1440 atgcatgagg
ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaag 1500
ggtggcggtg gctcgggcgg tggtggatct gggggaggag gcagcgggaa ttctcaggtg
1560 cagctgaagg agtcaggacc tggcctggtg gcgccctcac agagcctgtc
catcacatgc 1620 accgtctcag ggttctcatt aaccggctat ggtgtaaact
gggttcgcca gcctccagga 1680 aagggtctgg agtggctggg aatgatatgg
ggtgatggaa gcacagacta taattcagct 1740 ctcaaatcca gactatcgat
caccaaggac aactccaaga gccaagtttt cttaaaaatg 1800 aacagtctgc
aaactgatga cacagccaga tactactgtg ctcgagatgg ttatagtaac 1860
tttcattact atgttatgga ctactggggt caaggaacct cagtcaccgt ctcctctggg
1920 ggtggaggct ctggtggcgg tggatccggc ggaggtgggt cgggtggcgg
cggatctgac 1980 attgtgctca cccaatctcc agcttctttg gctgtgtctc
taggtcagag agccaccatc 2040 tcctgcagag ccagtgaaag tgttgaatat
tatgtcacaa gtttaatgca gtggtaccaa 2100 cagaaaccag gacagccacc
caaactcctc atctctgctg ctagcaacgt agaatctggg 2160 gtccctgcca
ggtttagtgg cagtgggtct gggacagact ttagcctcaa catccatcct 2220
gtggaggagg atgatattgc aatgtatttc tgtcagcaaa gtaggaaggt tccatggacg
2280 ttcggtggag gcaccaagct ggaaatcaaa cgttaatcta ga 2322
<210> SEQ ID NO 227 <211> LENGTH: 767 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: n2H7sssIgG1-H6-2e12HL (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(20) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (21)..(126) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(127)..(142) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(143)..(264) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(265)..(279) <223> OTHER INFORMATION: Hinge <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(497)..(514) <223> OTHER INFORMATION: EFD-BD2 Linker
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (515)..(635) <223> OTHER INFORMATION: VH2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (636)..(655) <223> OTHER INFORMATION: Linker2
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (656)..(767) <223> OTHER INFORMATION: VL2
<400> SEQUENCE: 227 Met Glu Ala Pro Ala Gln Leu Leu Phe Leu
Leu Leu Leu Trp Leu Pro 1 5 10 15 Asp Thr Thr Gly Gln Ile Val Leu
Ser Gln Ser Pro Ala Ile Leu Ser 20 25 30 Ala Ser Pro Gly Glu Lys
Val Thr Met Thr Cys Arg Ala Ser Ser Ser 35 40 45
Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 50
55 60 Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala
Arg 65 70 75 80 Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
Ile Ser Arg 85 90 95 Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
Gln Gln Trp Ser Phe 100 105 110 Asn Pro Pro Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys Asp Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ala Ser Gln Ala 130 135 140 Tyr Leu Gln Gln Ser
Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 145 150 155 160 Lys Met
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 165 170 175
His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala 180
185 190 Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys
Gly 195 200 205 Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
Tyr Met Gln 210 215 220 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
Tyr Phe Cys Ala Arg 225 230 235 240 Val Val Tyr Tyr Ser Asn Ser Tyr
Trp Tyr Phe Asp Val Trp Gly Thr 245 250 255 Gly Thr Thr Val Thr Val
Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr 260 265 270 His Thr Ser Pro
Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 275 280 285 Val Phe
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 290 295 300
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 305
310 315 320 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
Asn Ala 325 330 335 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
Tyr Arg Val Val 340 345 350 Ser Val Leu Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys Glu Tyr 355 360 365 Lys Cys Lys Val Ser Asn Lys Ala
Leu Pro Ala Pro Ile Glu Lys Thr 370 375 380 Ile Ser Lys Ala Lys Gly
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 385 390 395 400 Pro Pro Ser
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 405 410 415 Leu
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 420 425
430 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
435 440 445 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
Lys Ser 450 455 460 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
Met His Glu Ala 465 470 475 480 Leu His Asn His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys 485 490 495 Gly Gly Gly Gly Ser Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly 500 505 510 Asn Ser Gln Val Gln
Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro 515 520 525 Ser Gln Ser
Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 530 535 540 Gly
Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 545 550
555 560 Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser
Ala 565 570 575 Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys
Ser Gln Val 580 585 590 Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp
Thr Ala Arg Tyr Tyr 595 600 605 Cys Ala Arg Asp Gly Tyr Ser Asn Phe
His Tyr Tyr Val Met Asp Tyr 610 615 620 Trp Gly Gln Gly Thr Ser Val
Thr Val Ser Ser Gly Gly Gly Gly Ser 625 630 635 640 Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 645 650 655 Ile Val
Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 660 665 670
Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Val 675
680 685 Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
Lys 690 695 700 Leu Leu Ile Ser Ala Ala Ser Asn Val Glu Ser Gly Val
Pro Ala Arg 705 710 715 720 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
Ser Leu Asn Ile His Pro 725 730 735 Val Glu Glu Asp Asp Ile Ala Met
Tyr Phe Cys Gln Gln Ser Arg Lys 740 745 750 Val Pro Trp Thr Phe Gly
Gly Gly Thr Lys Leu Glu Ile Lys Arg 755 760 765 <210> SEQ ID
NO 228 <211> LENGTH: 2337 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7sssIgG1-H7-G281 HL (DNA) <400>
SEQUENCE: 228 aagcttgccg ccatggattt tcaagtgcag attttcagct
tcctgctaat cagtgcttca 60 gtcataatgt ccagaggaca aattgttctc
tcccagtctc cagcaatcct gtctgcatct 120 ccaggggaga aggtcacaat
gacttgcagg gccagctcaa gtgtaagtta catgcactgg 180 taccagcaga
agccaggatc ctcccccaaa ccctggattt atgccccatc caacctggct 240
tctggagtcc ctgctcgctt cagtggcagt gggtctggga cctcttactc tctcacaatc
300 agcagagtgg aggctgaaga tgctgccact tattactgcc agcagtggag
ttttaaccca 360 cccacgttcg gtgctgggac caagctggag ctgaaagatg
gcggtggctc gggcggtggt 420 ggatctggag gaggtgggag ctctcaggct
tatctacagc agtctggggc tgagtcggtg 480 aggcctgggg cctcagtgaa
gatgtcctgc aaggcttctg gctacacatt taccagttac 540 aatatgcact
gggtaaagca gacacctaga cagggcctgg aatggattgg agctatttat 600
ccaggaaatg gtgatacttc ctacaatcag aagttcaagg gcaaggccac actgactgta
660 gacaaatcct ccagcacagc ctacatgcag ctcagcagcc tgacatctga
agactctgcg 720 gtctatttct gtgcaagagt ggtgtactat agtaactctt
actggtactt cgatgtctgg 780 ggcacaggga ccacggtcac cgtctctgat
caggagccca aatcttgtga caaaactcac 840 acatccccac cgtgctcagc
acctgaactc ctggggggac cgtcagtctt cctcttcccc 900 ccaaaaccca
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 960
gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg
1020 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg
tgtggtcagc 1080 gtcctcaccg tcctgcacca ggactggctg aatggcaagg
agtacaagtg caaggtctcc 1140 aacaaagccc tcccagcccc catcgagaaa
acaatctcca aagccaaagg gcagccccga 1200 gaaccacagg tgtacaccct
gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1260 ctgacctgcc
tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1320
gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc
1380 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa
cgtcttctca 1440 tgctccgtga tgcatgaggc tctgcacaac cactacacgc
agaagagcct ctccctgtct 1500 ccgggtaaga attatggtgg cggtggctcg
ggcggtggtg gatctggagg aggtgggagt 1560 gggaattctc aggtgcagct
gaaggagtca ggacctggcc tggtggcgcc ctcacagagc 1620 ctgtccatca
catgcaccgt ctcagggttc tcattaaccg gctatggtgt aaactgggtt 1680
cgccagcctc caggaaaggg tctggagtgg ctgggaatga tatggggtga tggaagcaca
1740 gactataatt cagctctcaa atccagacta tcgatcacca aggacaactc
caagagccaa 1800 gttttcttaa aaatgaacag tctgcaaact gatgacacag
ccagatacta ctgtgctcga 1860 gatggttata gtaactttca ttactatgtt
atggactact ggggtcaagg aacctcagtc 1920 accgtctcct ctgggggtgg
aggctctggt ggcggtggat ccggcggagg tgggtcgggt 1980 ggcggcggat
ctgacattgt gctcacccaa tctccagctt ctttggctgt gtctctaggt 2040
cagagagcca ccatctcctg cagagccagt gaaagtgttg aatattatgt cacaagttta
2100 atgcagtggt accaacagaa accaggacag ccacccaaac tcctcatctc
tgctgctagc 2160 aacgtagaat ctggggtccc tgccaggttt agtggcagtg
ggtctgggac agactttagc 2220 ctcaacatcc atcctgtgga ggaggatgat
attgcaatgt atttctgtca gcaaagtagg 2280 aaggttccat ggacgttcgg
tggaggcacc aagctggaaa tcaaacgtta atctaga 2337 <210> SEQ ID NO
229 <211> LENGTH: 772 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: 2H7cscIgG1-STD1-2e12HL (w/2E12 leader) (AA)
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1)..(22) <223> OTHER INFORMATION: Leader
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (23)..(128) <223> OTHER INFORMATION: VL <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(129)..(144) <223> OTHER INFORMATION: Linker <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(145)..(265) <223> OTHER INFORMATION: VH <220> FEATURE:
<221> NAME/KEY: misc_feature <222> LOCATION:
(268)..(282) <223> OTHER INFORMATION: Hinge
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (500)..(519) <223> OTHER INFORMATION: EFD-BD2
Linker <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (520)..(640) <223> OTHER INFORMATION:
VH2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (641)..(660) <223> OTHER INFORMATION:
Linker2 <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (661)..(772) <223> OTHER INFORMATION:
VL2 <400> SEQUENCE: 229 Met Asp Phe Gln Val Gln Ile Phe Ser
Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Met Ser Arg Gly Gln
Ile Val Leu Ser Gln Ser Pro Ala Ile 20 25 30 Leu Ser Ala Ser Pro
Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 35 40 45 Ser Ser Val
Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 50 55 60 Pro
Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro 65 70
75 80 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
Gln Gln Trp 100 105 110 Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys 115 120 125 Asp Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Ser 130 135 140 Gln Ala Tyr Leu Gln Gln Ser
Gly Ala Glu Ser Val Arg Pro Gly Ala 145 150 155 160 Ser Val Lys Met
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 165 170 175 Asn Met
His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 180 185 190
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 195
200 205 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
Tyr 210 215 220 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
Tyr Phe Cys 225 230 235 240 Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr
Trp Tyr Phe Asp Val Trp 245 250 255 Gly Thr Gly Thr Thr Val Thr Val
Ser Asp Gln Glu Pro Lys Ser Cys 260 265 270 Asp Lys Thr His Thr Ser
Pro Pro Cys Ser Ala Pro Glu Leu Leu Gly 275 280 285 Gly Pro Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 290 295 300 Ile Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 305 310 315
320 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
325 330 335 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
Thr Tyr 340 345 350 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
Trp Leu Asn Gly 355 360 365 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile 370 375 380 Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val 385 390 395 400 Tyr Thr Leu Pro Pro
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 405 410 415 Leu Thr Cys
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 420 425 430 Trp
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 435 440
445 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
450 455 460 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met 465 470 475 480 His Glu Ala Leu His Asn His Tyr Thr Gln Lys
Ser Leu Ser Leu Ser 485 490 495 Pro Gly Lys Asn Tyr Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Asn Ser
Gln Val Gln Leu Lys Glu Ser Gly Pro 515 520 525 Gly Leu Val Ala Pro
Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 530 535 540 Gly Phe Ser
Leu Thr Gly Tyr Gly Val Asn Trp Val Arg Gln Pro Pro 545 550 555 560
Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Ser Thr 565
570 575 Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Lys Asp
Asn 580 585 590 Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln
Thr Asp Asp 595 600 605 Thr Ala Arg Tyr Tyr Cys Ala Arg Asp Gly Tyr
Ser Asn Phe His Tyr 610 615 620 Tyr Val Met Asp Tyr Trp Gly Gln Gly
Thr Ser Val Thr Val Ser Ser 625 630 635 640 Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 645 650 655 Gly Gly Gly Ser
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 660 665 670 Val Ser
Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 675 680 685
Val Glu Tyr Tyr Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 690
695 700 Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Val Glu
Ser 705 710 715 720 Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Ser 725 730 735 Leu Asn Ile His Pro Val Glu Glu Asp Asp
Ile Ala Met Tyr Phe Cys 740 745 750 Gln Gln Ser Arg Lys Val Pro Trp
Thr Phe Gly Gly Gly Thr Lys Leu 755 760 765 Glu Ile Lys Arg 770
<210> SEQ ID NO 230 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scs(s) -hIgG1 (DNA) <400>
SEQUENCE: 230 gagcccaaat cttctgacaa aactcacaca tctccaccga gctca 45
<210> SEQ ID NO 231 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - scs(s)
-hIgG1 (AA) <400> SEQUENCE: 231 Glu Pro Lys Ser Ser Asp Lys
Thr His Thr Ser Pro Pro Ser Ser 1 5 10 15 <210> SEQ ID NO 232
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - ccc(s) (DNA)
<400> SEQUENCE: 232 gagcccaaat cttgtgacaa aactcacaca
tctccaccgt gctca 45 <210> SEQ ID NO 233 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - ccc(s) (AA) <400> SEQUENCE: 233 Glu Pro Lys Ser Cys
Asp Lys Thr His Thr Ser Pro Pro Cys Ser 1 5 10 15 <210> SEQ
ID NO 234 <211> LENGTH: 24 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker polynucleotide - Linker
H8 (PN) <400> SEQUENCE: 234 gggtctccac cttctccgaa ttct 24
<210> SEQ ID NO 235 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker <400>
SEQUENCE: 235 Gly Ser Pro Pro Ser Pro Asn Ser 1 5 <210> SEQ
ID NO 236 <211> LENGTH: 21 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker polynucleotide - Linker H9 (PN) <400> SEQUENCE: 236
tctccacctt ctccgaattc t 21 <210> SEQ ID NO 237 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H9 (AA) <400> SEQUENCE: 237
Ser Pro Pro Ser Pro Asn Ser 1 5 <210> SEQ ID NO 238
<400> SEQUENCE: 238 000 <210> SEQ ID NO 239 <400>
SEQUENCE: 239 000 <210> SEQ ID NO 240 <211> LENGTH: 51
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker polynucleotide - Linker H11 (PN) <400> SEQUENCE: 240
gagcccacat ctaccgacaa aactcacaca tctccaccca gcccgaattc t 51
<210> SEQ ID NO 241 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H11
(AA) <400> SEQUENCE: 241 Glu Pro Thr Ser Thr Asp Lys Thr His
Thr Ser Pro Pro Ser Pro Asn 1 5 10 15 Ser <210> SEQ ID NO 242
<211> LENGTH: 51 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H12
(PN) <400> SEQUENCE: 242 gagcccacat ctaccgacaa aactcacaca
tctccaccca gcccgaattc t 51 <210> SEQ ID NO 243 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H12 (AA) <400> SEQUENCE: 243
Glu Pro Thr Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 1 5
10 15 Ser <210> SEQ ID NO 244 <211> LENGTH: 51
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker polynucleotide - Linker H13 (PN) <400> SEQUENCE: 244
gagcccacat ctaccgacaa aactcacaca tctccaccca gcccgaattc t 51
<210> SEQ ID NO 245 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H13
(AA) <400> SEQUENCE: 245 Glu Pro Lys Ser Ser Asp Lys Thr His
Thr Cys Pro Pro Cys Pro Asn 1 5 10 15 Ser <210> SEQ ID NO 246
<211> LENGTH: 36 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H15
(PN) <400> SEQUENCE: 246 ggcggtggtg gctcctgtcc accttgtccg
aattct 36 <210> SEQ ID NO 247 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H15 (AA) <400> SEQUENCE: 247 Gly Gly Gly Gly
Ser Cys Pro Pro Cys Pro Asn Ser 1 5 10 <210> SEQ ID NO 248
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H16
(PN) <400> SEQUENCE: 248 ctgtctgtga aagctgactt cctcactcca
tccatcggga attct 45 <210> SEQ ID NO 249 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H16 (AA) <400> SEQUENCE: 249 Leu Ser Val Lys
Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 1 5 10 15 <210>
SEQ ID NO 250 <211> LENGTH: 60 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H17 (PN) <400> SEQUENCE: 250
ctgtctgtga aagctgactt cctcactcca tccatctcct gtccaccttg cccgaattct
60 <210> SEQ ID NO 251 <211> LENGTH: 20 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Scorpion region linker -
Linker H17 (AA) <400> SEQUENCE: 251 Leu Ser Val Lys Ala Asp
Phe Leu Thr Pro Ser Ile Ser Cys Pro Pro 1 5 10 15 Cys Pro Asn Ser
20 <210> SEQ ID NO 252 <211> LENGTH: 45 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H18 (PN) <400> SEQUENCE: 252
ctgtctgtgc tcgctaactt cagtcagcca gagatcggga attct 45 <210>
SEQ ID NO 253 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H18
(AA) <400> SEQUENCE: 253 Leu Ser Val Leu Ala Asn Phe Ser Gln
Pro Glu Ile Gly Asn Ser 1 5 10 15 <210> SEQ ID NO 254
<211> LENGTH: 60 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H19
(PN) <400> SEQUENCE: 254 ctgtctgtgc tcgctaactt cagtcagcca
gagatctcct gtccaccttg cccgaattct 60 <210> SEQ ID NO 255
<211> LENGTH: 20
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H19 (AA) <400> SEQUENCE: 255 Leu Ser Val Leu
Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro 1 5 10 15 Cys Pro
Asn Ser 20 <210> SEQ ID NO 256 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker polynucleotide - Linker H20 (PN) <400> SEQUENCE: 256
ctgaaaatcc aggagagggt cagtaagcca aagatctcga attct 45 <210>
SEQ ID NO 257 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H20
(AA) <400> SEQUENCE: 257 Leu Lys Ile Gln Glu Arg Val Ser Lys
Pro Lys Ile Ser Asn Ser 1 5 10 15 <210> SEQ ID NO 258
<211> LENGTH: 60 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polypeptide - Linker H21 (PN)
<400> SEQUENCE: 258 ctgaaaatcc aggagagggt cagtaagcca
aagatctcct gtccaccttg cccgaattct 60 <210> SEQ ID NO 259
<211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker - Linker H21 (AA) <400>
SEQUENCE: 259 Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser
Cys Pro Pro 1 5 10 15 Cys Pro Asn Ser 20 <210> SEQ ID NO 260
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polypeptide - Linker H22 (PN)
<400> SEQUENCE: 260 ctggatgtga gtgagaggcc ttttcctcca
cacatccaga attct 45 <210> SEQ ID NO 261 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H22 (AA) <400> SEQUENCE: 261 Leu Asp Val Ser
Glu Arg Pro Phe Pro Pro His Ile Gln Asn Ser 1 5 10 15 <210>
SEQ ID NO 262 <211> LENGTH: 63 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H23 (PN) <400> SEQUENCE: 262
ctggatgtga gtgagaggcc ttttcctcca cacatccagt cctgtccacc ttgcccgaat
60 tct 63 <210> SEQ ID NO 263 <211> LENGTH: 21
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H23 (AA) <400> SEQUENCE: 263 Leu Asp Val Ser
Glu Arg Pro Phe Pro Pro His Ile Gln Ser Cys Pro 1 5 10 15 Pro Cys
Pro Asn Ser 20 <210> SEQ ID NO 264 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker polynucleotide - Linker H24 (DNA) <400> SEQUENCE: 264
cgggaacagc tggcagaggt cactttgagc ttgaaagcga attct 45 <210>
SEQ ID NO 265 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H24
(AA) <400> SEQUENCE: 265 Arg Glu Gln Leu Ala Glu Val Thr Leu
Ser Leu Lys Ala Asn Ser 1 5 10 15 <210> SEQ ID NO 266
<211> LENGTH: 60 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H25
(PN) <400> SEQUENCE: 266 cgggaacagc tggcagaggt cactttgagc
gtgaaagctt gtccaccctg cccgaattct 60 <210> SEQ ID NO 267
<211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker - Linker H25 (AA) <400>
SEQUENCE: 267 Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala
Cys Pro Pro 1 5 10 15 Cys Pro Asn Ser 20 <210> SEQ ID NO 268
<211> LENGTH: 45 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H26
(PN) <400> SEQUENCE: 268 cggattcacc agatgaactc cgagttgagc
gtgctcgcga attct 45 <210> SEQ ID NO 269 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H26 (AA) <400> SEQUENCE: 269 Arg Ile His Gln
Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 1 5 10 15 <210>
SEQ ID NO 270 <211> LENGTH: 60 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H27 (PN) <400> SEQUENCE: 270
cggattcacc agatgaactc cgagttgagc gtgctcgctt gtccaccctg cccgaattct
60 <210> SEQ ID NO 271 <211> LENGTH: 20 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Scorpion region linker -
Linker H27 (AA) <400> SEQUENCE: 271 Arg Ile His Gln Met Asn
Ser Glu Leu Ser Val Leu Ala Cys Pro Pro 1 5 10 15 Cys Pro Asn Ser
20 <210> SEQ ID NO 272 <211> LENGTH: 45 <212>
TYPE: DNA <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker
H28 (PN) <400> SEQUENCE: 272 gataccaaag ggaagaacgt cctcgagaag
atcttctcga attct 45 <210> SEQ ID NO 273 <211> LENGTH:
15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H28 (AA) <400> SEQUENCE: 273 Asp Thr Lys Gly
Lys Asn Val Leu Glu Lys Ile Phe Ser Asn Ser 1 5 10 15 <210>
SEQ ID NO 274 <211> LENGTH: 63 <212> TYPE: DNA
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H29 (PN) <400> SEQUENCE: 274
gataccaaag ggaagaacgt cctcgagaag atcttcgact cctgtccacc ttgcccgaat
60 tct 63 <210> SEQ ID NO 275 <211> LENGTH: 21
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H29 (AA) <400> SEQUENCE: 275 Asp Thr Lys Gly
Lys Asn Val Leu Glu Lys Ile Phe Asp Ser Cys Pro 1 5 10 15 Pro Cys
Pro Asn Ser 20 <210> SEQ ID NO 276 <211> LENGTH: 45
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker polynucleotide - Linker H30 (PN) <400> SEQUENCE: 276
ctgccacctg agacacagga gagtcaagaa gtcaccctga attct 45 <210>
SEQ ID NO 277 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H30
(AA) <400> SEQUENCE: 277 Leu Pro Pro Glu Thr Gln Glu Ser Gln
Glu Val Thr Leu Asn Ser 1 5 10 15 <210> SEQ ID NO 278
<211> LENGTH: 63 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H31
(PN) <400> SEQUENCE: 278 ctgccacctg agacacagga gagtcaagaa
gtcaccctgt cctgtccacc ttgcccgaat 60 tct 63 <210> SEQ ID NO
279 <211> LENGTH: 21 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker - Linker H31 (AA)
<400> SEQUENCE: 279 Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu
Val Thr Leu Ser Cys Pro 1 5 10 15 Pro Cys Pro Asn Ser 20
<210> SEQ ID NO 280 <211> LENGTH: 45 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker
polynucleotide - Linker H32 (PN) <400> SEQUENCE: 280
cggattcacc tgaacgtgtc cgagaggccc tttcctccga attct 45 <210>
SEQ ID NO 281 <211> LENGTH: 15 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H32
(AA) <400> SEQUENCE: 281 Arg Ile His Leu Asn Val Ser Glu Arg
Pro Phe Pro Pro Asn Ser 1 5 10 15 <210> SEQ ID NO 282
<211> LENGTH: 60 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H33
(PN) <400> SEQUENCE: 282 cggattcacc tgaacgtgtc cgagaggccc
tttcctccct gtccaccctg cccgaattct 60 <210> SEQ ID NO 283
<211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker - Linker H33 (AA) <400>
SEQUENCE: 283 Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro
Cys Pro Pro 1 5 10 15 Cys Pro Asn Ser 20 <210> SEQ ID NO 284
<400> SEQUENCE: 284 000 <210> SEQ ID NO 285 <400>
SEQUENCE: 285 000 <210> SEQ ID NO 286 <400> SEQUENCE:
286 000 <210> SEQ ID NO 287 <400> SEQUENCE: 287 000
<210> SEQ ID NO 288 <211> LENGTH: 39 <212> TYPE:
DNA <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H36
(PN) <400> SEQUENCE: 288 gggtgtccac cttgtccagg cggtggtgga
tcgaattct 39 <210> SEQ ID NO 289 <211> LENGTH: 13
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H36 (AA) <400> SEQUENCE: 289 Gly Cys Pro Pro
Cys Pro Gly Gly Gly Gly Ser Asn Ser 1 5 10 <210> SEQ ID NO
290 <400> SEQUENCE: 290 000 <210> SEQ ID NO 291
<400> SEQUENCE: 291 000 <210> SEQ ID NO 292 <400>
SEQUENCE: 292 000 <210> SEQ ID NO 293 <400> SEQUENCE:
293 000 <210> SEQ ID NO 294
<400> SEQUENCE: 294 000 <210> SEQ ID NO 295 <400>
SEQUENCE: 295 000 <210> SEQ ID NO 296 <211> LENGTH: 27
<212> TYPE: DNA <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker polynucleotide - Linker H40 (PN) <400> SEQUENCE: 296
ggatgtccac cttgtcccgc gaattct 27 <210> SEQ ID NO 297
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker - Linker H40 (AA) <400>
SEQUENCE: 297 Gly Cys Pro Pro Cys Pro Ala Asn Ser 1 5 <210>
SEQ ID NO 298 <400> SEQUENCE: 298 000 <210> SEQ ID NO
299 <211> LENGTH: 9 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker - Linker H41 <400>
SEQUENCE: 299 Gly Cys Pro Pro Cys Pro Ala Asn Ser 1 5 <210>
SEQ ID NO 300 <400> SEQUENCE: 300 000 <210> SEQ ID NO
301 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker - Linker H42(AA)
<400> SEQUENCE: 301 Gly Cys Pro Pro Cys Pro Asn Ser 1 5
<210> SEQ ID NO 302 <400> SEQUENCE: 302 000 <210>
SEQ ID NO 303 <400> SEQUENCE: 303 000 <210> SEQ ID NO
304 <211> LENGTH: 36 <212> TYPE: DNA <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker polynucleotide - Linker
H44 (PN) <400> SEQUENCE: 304 ggaggagcta gttgtccacc ttgtcccggg
aattct 36 <210> SEQ ID NO 305 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H44 (AA) <400> SEQUENCE: 305 Gly Gly Ala Ser
Cys Pro Pro Cys Pro Gly Asn Ser 1 5 10 <210> SEQ ID NO 306
<211> LENGTH: 36 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H45
(PN) <400> SEQUENCE: 306 ggaggagcca gttgtccacc ttgtgccggg
aattct 36 <210> SEQ ID NO 307 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H45 (AA) <400> SEQUENCE: 307 Gly Gly Ala Ser
Cys Pro Pro Cys Ala Gly Asn Ser 1 5 10 <210> SEQ ID NO 308
<211> LENGTH: 33 <212> TYPE: DNA <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker polynucleotide - Linker H46
<400> SEQUENCE: 308 ggaggagcca gttgtccacc ttgtgcgaat tct 33
<210> SEQ ID NO 309 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H46
<400> SEQUENCE: 309 Gly Gly Ala Ser Cys Pro Pro Cys Ala Asn
Ser 1 5 10 <210> SEQ ID NO 310 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H47 <400> SEQUENCE: 310 Leu Ser Val Lys Ala
Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 1 5 10 15 <210> SEQ
ID NO 311 <211> LENGTH: 12 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion region linker - Linker H48 <400>
SEQUENCE: 311 Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 1 5
10 <210> SEQ ID NO 312 <400> SEQUENCE: 312 000
<210> SEQ ID NO 313 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H50
<400> SEQUENCE: 313 Leu Ser Val Leu Ala Asn Phe Ser Gln Pro
Glu Ile Gly Asn Ser 1 5 10 15 <210> SEQ ID NO 314 <211>
LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H51 <400> SEQUENCE: 314 Leu
Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 1 5 10 15
<210> SEQ ID NO 315 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Synthetic peptide - Scorpion region
linker <400> SEQUENCE: 315 Ser Gln Pro Glu Ile Val Pro Ile
Ser Asn Ser 1 5 10 <210> SEQ ID NO 316 <211> LENGTH: 16
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H53
<400> SEQUENCE: 316 Ser Gln Pro Glu Ile Val Pro Ile Ser Cys
Pro Pro Cys Pro Asn Ser 1 5 10 15 <210> SEQ ID NO 317
<211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker - Linker H54 <400>
SEQUENCE: 317 Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys
Pro Pro Cys 1 5 10 15 Pro Asn Ser <210> SEQ ID NO 318
<211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker - Linker H55 <400>
SEQUENCE: 318 Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala
Asn Ser 1 5 10 15 <210> SEQ ID NO 319 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker - Linker H56 <400> SEQUENCE: 319 Gln Met Asn Ser Glu
Leu Ser Val Leu Ala Asn Ser 1 5 10 <210> SEQ ID NO 320
<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion region linker - Linker H57 <400>
SEQUENCE: 320 Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 1 5 10
<210> SEQ ID NO 321 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H58
<400> SEQUENCE: 321 Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp
Thr Cys Pro Asn Ser 1 5 10 15 <210> SEQ ID NO 322 <211>
LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H59 <400> SEQUENCE: 322 Lys
Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 1 5 10 15
<210> SEQ ID NO 323 <211> LENGTH: 14 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H60
<400> SEQUENCE: 323 Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe
Ser Met Asn Ser 1 5 10 <210> SEQ ID NO 324 <211>
LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H61 <400> SEQUENCE: 324 Glu
Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 1 5 10
15 Asp Cys Pro Asn Ser 20 <210> SEQ ID NO 325 <211>
LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H62 <400> SEQUENCE: 325 Gln
Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 1 5 10
15 His Cys Pro Asn Ser 20 <210> SEQ ID NO 326 <211>
LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion region linker - Linker H63 <400> SEQUENCE: 326 Asn
Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 1 5 10
15 Cys Asn Ser <210> SEQ ID NO 327 <211> LENGTH: 21
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion region
linker <400> SEQUENCE: 327 Gln Arg His Asn Asn Ser Ser Leu
Asn Thr Arg Thr Gln Lys Ala Arg 1 5 10 15 His Cys Pro Asn Ser 20
<210> SEQ ID NO 328 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H65
<400> SEQUENCE: 328 Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile
Glu Leu Gln Lys Asp Ser 1 5 10 15 Asp Cys Pro Asn Ser 20
<210> SEQ ID NO 329 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H66
<400> SEQUENCE: 329 Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile
Glu Leu Gln Lys Asp Ser 1 5 10 15 Asp Cys Pro Asn Ser 20
<210> SEQ ID NO 330 <211> LENGTH: 21 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H67
<400> SEQUENCE: 330 Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile
Glu Leu Gln Lys Asp Ser 1 5 10 15 Asp Cys Pro Asn Ser 20
<210> SEQ ID NO 331 <211> LENGTH: 118 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Scorpion region linker - Linker H68
<400> SEQUENCE: 331 Arg Thr Arg Tyr Leu Gln Val Ser Gln Gln
Leu Gln Gln Thr Asn Arg 1 5 10 15 Val Leu Glu Val Thr Asn Ser Ser
Leu Arg Gln Gln Leu Arg Leu Lys 20 25 30 Ile Thr Gln Leu Gly Gln
Ser Ala Glu Asp Leu Gln Gly Ser Arg Arg 35 40 45 Glu Leu Ala Gln
Ser Gln Glu Ala Leu Gln Val Glu Gln Arg Ala His 50 55 60 Gln Ala
Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg Gln Lys 65 70 75 80
Thr Lys Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu 85
90 95 Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr
Cys 100 105 110 Gly Ser Ala Asp Thr Cys 115 <210> SEQ ID NO
332 <211> LENGTH: 10 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: anti-CD-20 VL CDR1
<400> SEQUENCE: 332 Arg Ala Ser Ser Ser Val Ser Tyr Ile His 1
5 10 <210> SEQ ID NO 333 <211> LENGTH: 10 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: anti-CD-20 VL CDR1
<400> SEQUENCE: 333 Arg Ala Ser Ser Ser Val Ser Tyr Ile Val 1
5 10 <210> SEQ ID NO 334 <211> LENGTH: 9 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: anti-CD-20 VL CDR3
<400> SEQUENCE: 334 Gln Gln Trp Ser Phe Asn Pro Pro Thr 1 5
<210> SEQ ID NO 335 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: anti-CD-20 VL CDR3 <400>
SEQUENCE: 335 Gln Gln Tyr Ser Phe Asn Pro Pro Thr 1 5 <210>
SEQ ID NO 336 <211> LENGTH: 17 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: anti-CD-20 VH CDR2 <400>
SEQUENCE: 336 Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln
Lys Phe Lys 1 5 10 15 Gly <210> SEQ ID NO 337 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
anti-CD-20 VH CDR2 <400> SEQUENCE: 337 Ala Ile Tyr Pro Gly
Asn Gly Glu Thr Ser Tyr Asn Gln Lys Phe Lys 1 5 10 15 Gly
<210> SEQ ID NO 338 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: anti-CD20 VH CDR3 <400>
SEQUENCE: 338 Ser Val Tyr Tyr Ser Asn Tyr Trp Tyr Phe Asp Leu 1 5
10 <210> SEQ ID NO 339 <211> LENGTH: 12 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: anti-CD20 VH CDR3
<400> SEQUENCE: 339 Ser Val Tyr Tyr Gly Gly Tyr Trp Tyr Phe
Asp Leu 1 5 10 <210> SEQ ID NO 340 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: anti-CD20 VH
CDR3 <400> SEQUENCE: 340 Ser Tyr Tyr Ser Asn Ser Asp Trp Tyr
Phe Asp Leu 1 5 10 <210> SEQ ID NO 341 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: anti-CD20 VH
CDR3 <400> SEQUENCE: 341 Ser Tyr Tyr Ser Gly Gly Asp Trp Tyr
Phe Asp Leu 1 5 10 <210> SEQ ID NO 342 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: anti-CD20 VH
CDR3 <400> SEQUENCE: 342 Ser Tyr Lys Ser Asn Ser Tyr Trp Tyr
Phe Asp Leu 1 5 10 <210> SEQ ID NO 343 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: anti-CD20 VH
CDR3 <400> SEQUENCE: 343 Ser Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Leu 1 5 10 <210> SEQ ID NO 344 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: anti-CD-20 VH
CDR3 <400> SEQUENCE: 344 Ser Tyr Lys Ser Asn Ser Asp Trp Tyr
Phe Asp Leu 1 5 10 <210> SEQ ID NO 345 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: anti-CD20 VH
CDR3 <400> SEQUENCE: 345 Ser Tyr Lys Ser Gly Gly Asp Trp Tyr
Phe Asp Leu 1 5 10 <210> SEQ ID NO 346 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
core (2H7) sequence <400> SEQUENCE: 346 Gly Cys Pro Pro Cys
Pro Asn Ser 1 5 <210> SEQ ID NO 347 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Extension
sequence <400> SEQUENCE: 347 Ala Pro Glu Leu 1 <210>
SEQ ID NO 348 <211> LENGTH: 9 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Extension sequence <400>
SEQUENCE: 348 Ala Pro Glu Leu Gly Gly Gly Gly Ser 1 5 <210>
SEQ ID NO 349 <211> LENGTH: 14 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Extension sequence <400>
SEQUENCE: 349 Ala Pro Glu Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser 1 5 10 <210> SEQ ID NO 350 <211> LENGTH: 19
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Extension
sequence <400> SEQUENCE: 350 Ala Pro Glu Leu Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly 1 5 10 15 Gly Gly Ser <210>
SEQ ID NO 351 <211> LENGTH: 12 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Extended
scorpion linker <400> SEQUENCE: 351 Gly Cys Pro Pro Cys Pro
Asn Ser Ala Pro Glu Leu 1 5 10 <210> SEQ ID NO 352
<211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Extended scorpion linker <400> SEQUENCE: 352 Gly
Cys Pro Pro Cys Pro Asn Ser Ala Pro Glu Leu Gly Gly Gly Gly 1 5 10
15 Ser <210> SEQ ID NO 353 <211> LENGTH: 22 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Extended scorpion linker
<400> SEQUENCE: 353 Gly Cys Pro Pro Cys Pro Asn Ser Ala Pro
Glu Leu Gly Gly Gly Gly 1 5 10 15 Ser Gly Gly Gly Gly Ser 20
<210> SEQ ID NO 354 <211> LENGTH: 27 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Extended scorpion linker <400>
SEQUENCE: 354 Gly Cys Pro Pro Cys Pro Asn Ser Ala Pro Glu Leu Gly
Gly Gly Gly 1 5 10 15 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
20 25 <210> SEQ ID NO 355 <400> SEQUENCE: 355 000
<210> SEQ ID NO 356 <400> SEQUENCE: 356 000 <210>
SEQ ID NO 357 <400> SEQUENCE: 357 000 <210> SEQ ID NO
358 <400> SEQUENCE: 358 000 <210> SEQ ID NO 359
<400> SEQUENCE: 359 000 <210> SEQ ID NO 360 <400>
SEQUENCE: 360 000 <210> SEQ ID NO 361 <400> SEQUENCE:
361 000 <210> SEQ ID NO 362 <400> SEQUENCE: 362 000
<210> SEQ ID NO 363 <400> SEQUENCE: 363 000 <210>
SEQ ID NO 364 <400> SEQUENCE: 364 000 <210> SEQ ID NO
365 <400> SEQUENCE: 365 000 <210> SEQ ID NO 366
<211> LENGTH: 10 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: partial CH3 sequence <400> SEQUENCE: 366 Gln Lys
Ser Leu Ser Leu Ser Pro Gly Lys 1 5 10 <210> SEQ ID NO 367
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Partial CH3 sequence <400> SEQUENCE: 367 Gln Lys
Ser Leu Ser Leu Ser Pro Gly 1 5 <210> SEQ ID NO 368
<211> LENGTH: 1 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Partial CH3 sequence <400> SEQUENCE: 368 Gln 1
<210> SEQ ID NO 369 <211> LENGTH: 3 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: Partial CH3 sequence <400>
SEQUENCE: 369 Gln Lys Ser 1 <210> SEQ ID NO 370 <211>
LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Partial CH3 sequence <400> SEQUENCE: 370 Gln Lys Ser Leu Ser
Leu 1 5 <210> SEQ ID NO 371 <211> LENGTH: 5 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Partial CH3 sequence
<400> SEQUENCE: 371 Gln Lys Ser Leu Ser 1 5 <210> SEQ
ID NO 372 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: Scorpion linker <400> SEQUENCE: 372 Gly
Cys Pro Pro Cys 1 5 <210> SEQ ID NO 373 <211> LENGTH:
12 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
<400> SEQUENCE: 373 Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe
Ser Met 1 5 10 <210> SEQ ID NO 374 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: Scorpion linker
<400> SEQUENCE: 374 Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr
Cys 1 5 10 <210> SEQ ID NO 375
<211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: Scorpion linker <400> SEQUENCE: 375 Glu Pro Ala
Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 1 5 10 15 Asp
Cys <210> SEQ ID NO 376 <211> LENGTH: 18 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: Scorpion linker <400>
SEQUENCE: 376 Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln
Lys Ala Arg 1 5 10 15 His Cys <210> SEQ ID NO 377 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION:
Scorpion linker <400> SEQUENCE: 377 Asn Ser Leu Phe Asn Gln
Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 1 5 10 15 Cys <210>
SEQ ID NO 378 <211> LENGTH: 10 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: anti-CD20 VL CDR1 (TRU-015)
<400> SEQUENCE: 378 Arg Ala Ser Ser Ser Val Ser Tyr Met His 1
5 10 <210> SEQ ID NO 379 <211> LENGTH: 13 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: anti-CD20 VH CDR3 (TRU-015)
<400> SEQUENCE: 379 Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr
Phe Asp Val 1 5 10 <210> SEQ ID NO 380 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 380 Cys Pro Pro Cys 1 <210> SEQ ID NO
381 <211> LENGTH: 18 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: linker peptide <400> SEQUENCE: 381 Asn Tyr
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 1 5 10 15
Ser Gly <210> SEQ ID NO 382 <211> LENGTH: 36
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: linker peptide
<400> SEQUENCE: 382 Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly 1 5 10 15 Ser Gly Asn Tyr Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly 20 25 30 Gly Gly Ser Gly 35
<210> SEQ ID NO 383 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: linker peptide <400> SEQUENCE:
383 Gly Gly Gly Gly Ser Gly 1 5 <210> SEQ ID NO 384
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: linker peptide <400> SEQUENCE: 384 Asn Tyr Gly
Gly Gly Gly Ser Gly 1 5 <210> SEQ ID NO 385 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: linker
peptide <400> SEQUENCE: 385 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly 1 5 10 <210> SEQ ID NO 386 <211> LENGTH: 13
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: linker peptide
<400> SEQUENCE: 386 Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly 1 5 10 <210> SEQ ID NO 387 <211> LENGTH: 16
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: linker peptide
<400> SEQUENCE: 387 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly 1 5 10 15 <210> SEQ ID NO 388
<211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: linker peptide <400> SEQUENCE: 388 Gly Cys Pro
Pro Cys Pro 1 5 <210> SEQ ID NO 389 <211> LENGTH: 5
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: linker peptide
<400> SEQUENCE: 389 Asn Ser Gln Val Gln 1 5 <210> SEQ
ID NO 390 <211> LENGTH: 15 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: linker peptide <400> SEQUENCE: 390 Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1 5 10 15
<210> SEQ ID NO 391 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: peptide sequence typically
preceeding CDR-H2 <400> SEQUENCE: 391 Leu Glu Trp Ile Gly 1 5
<210> SEQ ID NO 392 <211> LENGTH: 10 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: peptide sequence typically following
CDR-H2 <220> FEATURE: <221> NAME/KEY: MISC_FEATURE
<222> LOCATION: (2)..(2) <223> OTHER INFORMATION: Xaa
may be Arg or Leu <220> FEATURE: <221> NAME/KEY:
MISC_FEATURE <222> LOCATION: (7)..(7) <223> OTHER
INFORMATION: Xaa may be Ala or Thr <400> SEQUENCE: 392
Lys Xaa Ile Val Phe Thr Xaa Ser Ile Ala 1 5 10 <210> SEQ ID
NO 393 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: peptide sequence typically following CDR-L3
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (3)..(3) <223> OTHER INFORMATION: Xaa can be any
naturally occurring amino acid <400> SEQUENCE: 393 Phe Gly
Xaa Gly 1 <210> SEQ ID NO 394 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: linker peptide
<400> SEQUENCE: 394 Asp Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser 1 5 10 15 <210> SEQ ID NO 395 <211>
LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: linker
peptide <400> SEQUENCE: 395 Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser 20
<210> SEQ ID NO 396 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: heavy chain variant end peptide
sequence <400> SEQUENCE: 396 Val Thr Val Ser 1 <210>
SEQ ID NO 397 <211> LENGTH: 5 <212> TYPE: PRT
<213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: heavy chain variant end peptide
sequence <400> SEQUENCE: 397 Val Thr Val Ser Ser 1 5
<210> SEQ ID NO 398 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Unknown <220> FEATURE: <223>
OTHER INFORMATION: CD20 motif recognized by 2H7 antibody
<400> SEQUENCE: 398 Ala Asn Pro Ser 1 <210> SEQ ID NO
399 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: scorpion binding domain <400> SEQUENCE:
399 Ser Tyr Ile Val 1 <210> SEQ ID NO 400 <211> LENGTH:
4 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: scorpion
binding domain <400> SEQUENCE: 400 Ser Tyr Ile His 1
<210> SEQ ID NO 401 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: scorpion binding domain <400>
SEQUENCE: 401 Asn Ser Tyr Trp 1 <210> SEQ ID NO 402
<211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: scorpion binding domain <400> SEQUENCE: 402 Cys
Gln Gln Trp 1 <210> SEQ ID NO 403 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: partial
scorpion linker sequence <400> SEQUENCE: 403 Cys Cys Cys Pro
1 <210> SEQ ID NO 404 <211> LENGTH: 4 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: partial scorpion linker sequence
<400> SEQUENCE: 404 Cys Ser Cys Ser 1 <210> SEQ ID NO
405 <211> LENGTH: 4 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: partial scorpion linker sequence <400>
SEQUENCE: 405 Ser Cys Cys Ser 1 <210> SEQ ID NO 406
<211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM:
Artificial Sequence <220> FEATURE: <223> OTHER
INFORMATION: partial scorpion linker sequence <400> SEQUENCE:
406 Ser Cys Cys Pro 1 <210> SEQ ID NO 407 <211> LENGTH:
4 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence
<220> FEATURE: <223> OTHER INFORMATION: partial
scorpion linker sequence <400> SEQUENCE: 407 Cys Ser Ser Ser
1 <210> SEQ ID NO 408 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: linker peptide <400> SEQUENCE:
408 Gly Gly Gly Gly Ser 1 5 <210> SEQ ID NO 409 <211>
LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: linker
peptide <400> SEQUENCE: 409 Glu Pro Lys Ser Thr Asp Lys Thr
His Thr Cys Pro Pro Cys Pro Asn 1 5 10 15 Ser <210> SEQ ID NO
410 <211> LENGTH: 17 <212> TYPE: PRT <213>
ORGANISM: Artificial Sequence <220> FEATURE: <223>
OTHER INFORMATION: linker peptide <400> SEQUENCE: 410 Glu Pro
Lys Ser Thr Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asn 1 5 10 15
Ser
<210> SEQ ID NO 411 <211> LENGTH: 15 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: linker peptide <400> SEQUENCE:
411 Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Asn Ser 1 5
10 15 <210> SEQ ID NO 412 <211> LENGTH: 13 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: linker peptide <400>
SEQUENCE: 412 Gly Gly Gly Ala Ser Cys Pro Pro Cys Pro Gly Asn Ser 1
5 10 <210> SEQ ID NO 413 <211> LENGTH: 13 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: linker peptide <400>
SEQUENCE: 413 Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 1
5 10 <210> SEQ ID NO 414 <211> LENGTH: 12 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: linker peptide <400>
SEQUENCE: 414 Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Asn Ser 1 5
10 <210> SEQ ID NO 415 <211> LENGTH: 11 <212>
TYPE: PRT <213> ORGANISM: Artificial Sequence <220>
FEATURE: <223> OTHER INFORMATION: linker peptide <400>
SEQUENCE: 415 Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 1 5 10
<210> SEQ ID NO 416 <211> LENGTH: 20 <212> TYPE:
PRT <213> ORGANISM: Artificial Sequence <220> FEATURE:
<223> OTHER INFORMATION: linker peptide <400> SEQUENCE:
416 Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser
1 5 10 15 Asp Cys Asn Ser 20 <210> SEQ ID NO 417 <211>
LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Artificial
Sequence <220> FEATURE: <223> OTHER INFORMATION: linker
peptide <400> SEQUENCE: 417 Gln Arg His Asn Asn Ser Ser Leu
Asn Thr Arg Thr Gln Lys Ala Arg 1 5 10 15 His Cys Asn Ser 20
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