U.S. patent application number 15/660881 was filed with the patent office on 2017-11-30 for electromagnetic radiation targeting devices, assemblies, systems and methods.
The applicant listed for this patent is ROCOMP GLOBAL, L.L.C.. Invention is credited to SCOTT DAVID COMPTON, CHARLES BRIAN ROGERS.
Application Number | 20170340896 15/660881 |
Document ID | / |
Family ID | 51300266 |
Filed Date | 2017-11-30 |
United States Patent
Application |
20170340896 |
Kind Code |
A1 |
ROGERS; CHARLES BRIAN ; et
al. |
November 30, 2017 |
ELECTROMAGNETIC RADIATION TARGETING DEVICES, ASSEMBLIES, SYSTEMS
AND METHODS
Abstract
The present application is directed to devices, assemblies,
systems and methods for targeting one or more sites with
electromagnetic radiation. The devices, assemblies and systems are
operationally configured to transform and convey electromagnetic
radiation to one or more targeted sites. The devices, assemblies
and systems may also convey one or more fluids or fluid solutions
to the one or more targeted sites.
Inventors: |
ROGERS; CHARLES BRIAN;
(DUNEDIN, FL) ; COMPTON; SCOTT DAVID; (HOUSTON,
TX) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
ROCOMP GLOBAL, L.L.C. |
Houston |
TX |
US |
|
|
Family ID: |
51300266 |
Appl. No.: |
15/660881 |
Filed: |
July 26, 2017 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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14174855 |
Feb 7, 2014 |
9717927 |
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15660881 |
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61800455 |
Mar 15, 2013 |
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61785817 |
Mar 14, 2013 |
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61761702 |
Feb 7, 2013 |
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Current U.S.
Class: |
1/1 |
Current CPC
Class: |
A61B 18/24 20130101;
A61N 2005/063 20130101; A61N 2005/0632 20130101; A61N 2005/0664
20130101; A61N 5/0601 20130101; A61N 2005/0602 20130101; A61B
2018/00404 20130101; A61N 2005/0644 20130101; A61N 5/0624 20130101;
A61B 2018/20355 20170501; A61B 2018/206 20130101 |
International
Class: |
A61N 5/06 20060101
A61N005/06; A61B 18/24 20060101 A61B018/24 |
Claims
1. A system for targeting one or more target sites of a subject
with electromagnetic radiation, including: a radiant energy source
including an enclosure housing internal circuitry including light
emitting diodes operationally configured to produce electromagnetic
radiation across the entire electromagnetic spectrum; one or more
fluid sources; one or more radiant energy conduits in radiant
communication with the radiant energy source; a treatment device
including (1) a first inlet in radiant communication with the
radiant energy source via one or more radiant conduits, (2) a
second inlet in fluid communication with the one or more fluid
sources, wherein the first inlet is fluidly sealed from the second
inlet; (3) transformation optics and (4) a waveguide operationally
configured to convey transformed electromagnetic radiation to the
one or more target sites; wherein a wavelength and amplitude of
radiant energy generated by the radiant energy source at any given
moment may be determined in a manner effective to emit a particular
wavelength and amplitude of radiant energy to the one or more
target sites according to one or more treatment operations, the
emission of radiant energy being defined by one or more parameters
selected from the group consisting of the index of refraction, the
total internal reflection, the numerical aperture, and combinations
thereof of the one or more radiant energy conduits, the
transformation optics and the waveguide.
2. The system of claim 1 wherein the internal circuitry includes
(1) a controller operationally configured to programmatically
adjust optical power output of each light emitting diode in real
time according to measured light intensity and the programmable
optical power output, the controller having a processor with memory
with programs stored therein and (2) an interface operationally
configured to load, reload, update electronically stored treatment
data and to transfer patient treatment data.
3. The system of claim 1 wherein the internal circuitry includes a
controller for programmatically controlling the amount of current
delivered to the light emitting diodes, the controller having a
processor using memory, the controller having an input device for
inputting commands and an output device for displaying information
on the enclosure.
4. The system of claim 1 wherein the internal circuitry includes a
controller with a processor with timers operationally configured to
control the duration of operation of the light emitting diodes.
5. A system for targeting one or more blood contaminants of an
animal with one or more treatments of electromagnetic radiation
over one or more durations, including: a radiant energy source
including an enclosure housing internal circuitry including light
emitting diodes operationally configured to produce electromagnetic
radiation across the entire electromagnetic spectrum; one or more
fluid sources; one or more radiant energy conduits in radiant
communication with the radiant energy source; a treatment device
for conveying electromagnetic radiation to one or more subcutaneous
sites, the treatment device having a housing operationally
configured to convey electromagnetic radiation and fluid there
through, the housing having a first inlet for receiving
electromagnetic radiation from the radiant energy source, a second
inlet for receiving fluid from one or more fluid sources and an
outlet for emitting electromagnetic radiation and fluid received
through the first and second inlets; the housing being
operationally configured to fluidly seal the first inlet from the
second inlet and transform electromagnetic radiation received
through the first inlet; wherein one or more of (1) intensity of
the electromagnetic radiation, (2) wavelength of spectral energy
and (3) duration of exposure of the one or more blood contaminants
to electromagnetic radiation may be determined according to
electromagnetic radiation interaction characteristics of the one or
more blood contaminants targeted.
6. The system of claim 5 wherein one or more of (1) intensity of
the electromagnetic radiation, (2) wavelength of spectral energy
and (3) duration of exposure of the one or more blood contaminants
to electromagnetic radiation may be determined for selective
destruction of one or more target blood contaminants.
7. The system of claim 5 wherein the fluid has a known refractive
index and the system is operationally configured to produce a
particular output of electromagnetic radiation at the radiant
energy source and transform the radiant energy within the treatment
device to produce a desired radiant energy emitted out through the
outlet of the treatment device.
8. The system of claim 7 whereby as the refractive index of the
fluid introduced into the treatment device changes from the known
refractive index, the output of electromagnetic radiation at the
radiation energy source is adjustable to maintain the emission of
said desired radiant energy emission out through the outlet.
9. The system of claim 5 further including a waveguide in radiant
communication with the first inlet and in fluid communication with
the second inlet.
10. The system of claim 9 wherein the waveguide is a hollow member
having a high index of refraction core surrounded by a low index of
refraction cladding.
11. The system of claim 9 wherein a wavelength and amplitude of
electromagnetic radiation generated by the radiant energy source at
any given moment may be determined in a manner effective to emit a
particular wavelength and amplitude of radiant energy to one or
more blood contaminants of an animal according to one or more
parameters selected from the group consisting of waveguide
absorption properties of the one or more radiant energy conduits,
waveguide scattering properties of the one or more radiant energy
conduits, the waveguide employed, compression of electromagnetic
radiation during the transition from the one or more radiant energy
conduits into the waveguide of smaller cross section, and
combinations thereof.
12. The system of claim 5 whereby conveying multiple treatments of
electromagnetic radiation over one or more durations to an animal
has cumulative physiological effects.
13. The system of claim 5 whereby one treatment of electromagnetic
radiation may be employed for selective destruction of one or more
target blood contaminants of an animal and another treatment of
electromagnetic radiation may include non-destructive emanation of
electromagnetic radiation to the animal.
14. The system of claim 9 wherein the waveguide is a
nanoneedle.
15. The system of claim 9 wherein the radiant energy source may be
calibrated according to the waveguide employed for use in one or
more treatments.
16. The system of claim 9 wherein the waveguide is an injectable
liquid light guide.
17. The system of claim 5 whereby frequency and amplitude of the
electromagnetic radiation may be controlled via non-linear
conversions via the addition of quantum dots to fluid of the one or
more fluid sources.
18. A device for targeting one or more sites with electromagnetic
radiation including a housing having (1) a power source therein,
(2) one or more sources of electromagnetic radiation therein, (3) a
fluid inlet, (4) a hollow member in radiant communication with the
source of electromagnetic radiation, the hollow member being
operationally configured to emit electromagnetic radiation and
fluid out of the housing to the one or more sites.
19. The device of claim 18 wherein the fluid inlet is fluidly
sealed from the one or more sources of electromagnetic
radiation.
20. An assembly for receiving electromagnetic radiation and
conveying the electromagnetic radiation to one or more target
sites, including: a cable member operationally configured to
receive electromagnetic radiation from a source of electromagnetic
radiation; an interconnect member in radiant communication with the
cable member and in fluid communication with one or more fluid
sources via a fluid inlet; and a hollow dispensing member having an
outlet for the electromagnetic radiation and fluid from the one or
more fluid sources; wherein the cable member includes a first
opening operationally configured to mate with a terminal end of a
waveguide and a second opening operationally configured to mate
with the interconnect member; and wherein the first opening of the
cable member is fluidly sealed from the fluid inlet of the
interconnect member.
21. The assembly of claim 20 wherein (1) the cable member includes
an electrical connector, a printed circuit board, one or more light
emitting diodes and a window member; (2) the interconnect member
includes a main body mateable with the second opening of the cable
member, a window member, an integrated circuit, a cavity in fluid
communication with the fluid inlet, a nose with an outlet in fluid
communication with the cavity and in radiant communication with the
cable member, and a connection member attachable to the main body;
and (3) the hollow dispensing member is releasably attachable to
the connection member.
22. The assembly of claim 21 wherein the integrated circuit
electronically communicates assembly operating information to the
electrical connector and printed circuit board that electrically
communicate operating information to the source of electromagnetic
radiation.
23. The assembly of claim 21 wherein the integrated circuit
electronically communicates with the source of electromagnetic
radiation to validate authenticity of the interconnect member
before the source of electromagnetic radiation may be operated.
24. The assembly of claim 21 including wireless communication
between the assembly and the source of electromagnetic
radiation.
25. The assembly of claim 24 wherein wireless communication is
performed using radio-frequency identification.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] The present application is a continuation of U.S. patent
application Ser. No. 14/174,855 filed on Feb. 7, 2014, which is
entitled to the benefit of the filing date of the prior-filed U.S.
provisional applications No. 61/761,702, filed on Feb. 7, 2013, No.
61/785,817, filed on Mar. 14, 2013 and No. 61/800,455, filed on
Mar. 15, 2013.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
[0002] Not applicable.
FIELD OF THE APPLICATION
[0003] The application relates generally to the conveyance of
electromagnetic radiation to target sites such as superficial
anatomical locations ("surface locations"), subsurface locations,
and internal locations of a subject.
BACKGROUND
[0004] Waveguides such as optical fiber have been used to deliver
light radiation and light laser energy topically and
subcutaneously. Optical fiber, which is made of pure glass (or
silica) is subject to breakage. Broken shards of optical fiber
contacting an individual may cause injury or result in other
undesired consequences. In addition, bodily fluids or other
chemicals and foreign substances may contaminate such
waveguides.
[0005] The emanation of electromagnetic radiation to target sites
without contacting the sites or otherwise exposing such sites to
breakable materials like optical fiber is desired.
SUMMARY
[0006] The present application is directed to device for targeting
one or more sites with electromagnetic radiation, the device having
a housing operationally configured to (1) receive electromagnetic
radiation through a first inlet and fluid through a second inlet,
(2) fluidly seal the first inlet from the second inlet and (3) emit
the electromagnetic radiation and fluid through a first outlet of
the housing.
[0007] The present application is also directed to an assembly for
targeting electromagnetic radiation at one or more sites including
(1) a first member operationally configured to receive
electromagnetic radiation therein; (2) a second member attachable
to the first member and operationally configured to receive fluid
therein; and (3) a third member attachable to the second member,
the third member having an outlet operationally configured to emit
electromagnetic radiation received by the first member and fluid
received by the second member.
[0008] The present application is also directed to a system for
targeting electromagnetic radiation at one or more sites including
(1) an electromagnetic radiation source; (2) a fluid source; (3) a
waveguide in radiant communication with the electromagnetic
radiation source; and (4) an assembly including (A) a device having
a first inlet for receiving electromagnetic radiation from the
waveguide, a second inlet for receiving fluid from the fluid source
and a first outlet for emitting electromagnetic radiation and fluid
received through the first and second inlets, the device being
operationally configured to transform electromagnetic radiation
received through the first inlet and (B) a hollow member having an
open proximal end releasably attachable to the first outlet and an
open distal end operationally configured for the emission of
electromagnetic radiation and fluid out of the hollow member.
[0009] The present application is also directed to a method of
targeting an animal blood vessel with electromagnetic radiation
including (1) providing an assembly including (A) a device having
an inlet for receiving electromagnetic radiation from an
electromagnetic radiation source, an inlet for receiving fluid from
a fluid source and an outlet for emitting the electromagnetic
radiation and fluid, the device being operationally configured to
transform the electromagnetic radiation received therein and (B) a
hollow puncture forming member attachable to the outlet of the
device; (2) connecting the device to an electromagnetic radiation
source and a fluid source; (3) directing an open distal end of the
hollow puncture forming member into the blood vessel; and (4)
conveying electromagnetic radiation and fluid to the device wherein
the device transforms the electromagnetic radiation emitting
transformed electromagnetic radiation and fluid out through the
distal end of the hollow puncture forming member into the blood
vessel. The present application is also directed to a method of
controlling the propagation of electromagnetic radiation conveyed
to one or more target sites by (1) providing a device for conveying
electromagnetic radiation and fluid there through to one or more
target sites, the device being constructed from one or more
materials providing one or more optical properties of the device,
the device having a housing including an electromagnetic radiation
inlet, a fluid inlet, and an outlet for the electromagnetic
radiation and the fluid; and (2) providing one or more fluids to be
delivered through the device, the one or more fluids having one or
more optical properties.
BRIEF DESCRIPTION OF THE FIGURES
[0010] FIG. 1 illustrates a simplified embodiment of a system of
this application.
[0011] FIG. 2 illustrates another simplified embodiment of a system
of this application.
[0012] FIG. 3 illustrates a side view of a simplified embodiment of
a treatment device.
[0013] FIG. 4 illustrates a sectional view of the treatment device
of FIG. 3.
[0014] FIG. 5 illustrates a sectional view of the treatment device
of FIG. 3 including a waveguide attached thereto.
[0015] FIG. 6 illustrates a sectional view of the treatment device
of FIG. 3 including a waveguide and hollow member attached
thereto.
[0016] FIG. 7 illustrates another sectional side view of a
simplified embodiment of a treatment device including a waveguide
attached thereto.
[0017] FIG. 8 illustrates another sectional side view of the
treatment device of FIG. 7.
[0018] FIG. 9 illustrates another sectional side view of a
simplified embodiment of a treatment device.
[0019] FIG. 10 illustrates a partial phantom side view of another
simplified embodiment of a treatment device.
[0020] FIG. 11 illustrates a sectional side view of another
simplified embodiment of a treatment device.
[0021] FIG. 12 illustrates a distal portion of an embodiment of a
hollow member of the present application.
[0022] FIG. 13 illustrates a distal portion of an embodiment of a
hollow member of the present application.
[0023] FIG. 14A illustrates a side view of another embodiment of a
treatment device.
[0024] FIG. 14B illustrates a perspective view of the embodiment of
FIG. 14A.
[0025] FIG. 14C illustrates an exploded view of the embodiment of
FIG. 14A.
[0026] FIG. 15A illustrates a side view of another embodiment of a
treatment device.
[0027] FIG. 15B illustrates a perspective view of the embodiment of
FIG. 15A.
[0028] FIG. 15C illustrates a sectional view of the embodiment of
FIG. 15A including a waveguide connector.
[0029] FIG. 16 illustrates a sectional view of a simplified
embodiment of a treatment device including a waveguide attached
thereto.
[0030] FIG. 17 illustrates a sectional view of a simplified
embodiment of a treatment device including a waveguide attached
thereto illustrating propagation and transformation of the
electromagnetic radiation through the treatment device.
[0031] FIG. 18 illustrates another sectional view of a simplified
embodiment of a treatment device including a waveguide attached
thereto illustrating propagation and transformation of
electromagnetic radiation through the treatment device.
[0032] FIG. 19 illustrates another sectional view of a simplified
embodiment of a treatment device including a waveguide attached
thereto illustrating propagation and transformation of
electromagnetic radiation through the treatment device.
[0033] FIG. 20 illustrates another simplified embodiment of a
treatment device of the present application including a waveguide
and hollow member attached thereto.
[0034] FIG. 21 illustrates another simplified embodiment of a
treatment device of the present application including a waveguide
and hollow member attached thereto.
[0035] FIG. 22 illustrates a sectional view of a simplified
embodiment of a treatment device of the present application
including a waveguide and hollow member attached thereto.
[0036] FIG. 23 illustrates a sectional view of a simplified
embodiment of a treatment device of the present application
including a waveguide and hollow member attached thereto.
[0037] FIG. 24 illustrates a sectional view of a simplified
embodiment of a treatment assembly of the present application
including a waveguide and hollow member attached thereto.
[0038] FIG. 25 illustrates a partial sectional view of a simplified
embodiment of a treatment assembly of the present application
including a waveguide and hollow member attached thereto.
[0039] FIG. 26 illustrates a partial sectional view of a treatment
assembly of the present application including a waveguide and
hollow member attached thereto illustrating propagation and
transformation of electromagnetic radiation through the treatment
device.
[0040] FIG. 27 illustrates an exploded view of a treatment assembly
of the present application.
[0041] FIG. 28 illustrates a sectional view of the treatment
assembly of FIG. 27.
[0042] FIG. 29 illustrates an exploded view of an exemplary cable
member and a waveguide.
[0043] FIG. 30A illustrates an exploded view of an exemplary
interconnect member.
[0044] FIG. 30B illustrates a sectional side view of the
interconnect member of FIG. 30A.
[0045] FIG. 30C illustrates a side view of the interconnect member
of FIG. 30A.
[0046] FIG. 30D illustrates a perspective view of the interconnect
member of FIG. 30A.
[0047] FIG. 31 illustrates a perspective view of an assembly of the
present application.
[0048] FIG. 32 illustrates a sectional side view of the assembly of
FIG. 31.
[0049] FIG. 33 illustrates a sectional side view of another
simplified embodiment of a treatment device of the present
application.
[0050] FIG. 34 illustrates a perspective view of another simplified
embodiment of a treatment assembly of the present application.
BRIEF DESCRIPTION
[0051] Before describing the invention in detail, it is to be
understood that the present device, system and method are not
limited to particular embodiments. It is also to be understood that
the terminology used herein is for the purpose of describing
particular embodiments only, and is not intended to be limiting. As
used in this specification and the appended claims, the term "blood
contaminant" may refer to one or more viral contaminants, bacterial
contaminants, pathogenic organisms, pathogenic microorganisms,
toxins, organisms, poisons, abnormal cells, allergens, other
agents, and combinations thereof. Herein, "toxin" or "toxins" may
be characterized and include one or more neurotoxins, hemotoxins,
phototoxins, exotoxins, endotoxins, biotoxins, man-made toxins, and
combinations thereof. The phrase "pathogenic organism" or
"pathogen" herein refers to any particle and/or organism that can
enter the body of a living subject including, but not necessarily
limited to microorganisms such as bacteria, viruses, fungi,
protozoa, multicellular parasites, and aberrant proteins
("prions"), and combinations thereof. In terms of animals, the
phrase "blood-borne pathogen" herein refers to one or more
infectious microorganisms present in an animal's blood that may
cause sickness, disease or other abnormal state in an animal. A
"blood-borne disease" means a disease that can be spread through
contamination of the blood and/or blood components and/or cellular
blood matter and/or blood plasma protein fractions of an animal. In
particular, a blood-borne disease may refer to any disease of the
blood, involving the red blood cells (erythrocytes), white blood
cells (leukocytes), or platelets (thrombocytes) or the tissues in
which these elements are formed, e.g., the bone marrow, lymph
nodes, spleen. The phrase "emerging infectious disease" ("EID")
refers to an infectious disease whose incidence has increased in
recent years with prospects of continual increasing. As understood
by persons of ordinary skill in the art, EIDs are caused by newly
identified species or strains, e.g., severe acute respiratory
syndrome ("SARS") and acquired immune deficiency syndrome ("AIDS"),
which (1) may have evolved from a known infection, e.g. influenza,
or (2) spread to a new population, e.g., West Nile virus, or area
undergoing ecologic transformation, e.g., Lyme disease, or be
reemerging infections, like drug resistant tuberculosis. The phrase
"infectious disease" (also referred to as "transmissible diseases"
and/or "communicable diseases") suitably includes a clinically
evident illness, i.e., characteristic medical signs and/or symptoms
of disease, resulting from the infection, presence and growth of
pathogenic biological agents in an individual host organism.
[0052] Herein, a "blood infection" may be referred to as a
condition wherein the blood cells and/or blood plasma get infected
by one or more pathogens and their toxins. When referring to blood
infections, the term "sepsis" refers to a condition where the
entire body is involved in a toxic condition with microorganisms
and their toxins spreading from one site to another. The term
"septicemia" refers to a condition where there are active pathogens
present in the bloodstream itself. A "blood disorder" refers to
conditions that are mostly genetic and non-contagious in nature.
The phrase "blood constituent" may refer to red blood cells and/or
blood platelets and/or blood plasma. The phrase "cellular blood
constituent" may refer to red blood cells and/or blood platelets.
The phrase "blood product" may refer to one or more blood
constituents either alone or in combination, and either with or
without other blood constituents or other substances. Thus, blood
products may include for example, whole blood and blood plasma.
[0053] Blood-borne pathogens may be transferred to an animal via
inhalation, direct contact with contaminated blood or fluid(s) of
another animal. Depending on the animal in question, pathogens may
be transferred through open sores, cuts, abrasions, acne, blisters,
sun-damaged skin, mucous membranes of the eyes, mucous membranes of
the mouth, mucous membranes of the nose, mucous membranes of the
genital area, mucous membranes of the anus, and combinations
thereof. Exemplary animal fluids may include, but are not
necessarily limited to animal semen, animal secretions,
cerebrospinal fluid, synovial fluid, pleural fluid, peritoneal
fluid, amniotic fluid, saliva, and combinations thereof. The phrase
"vector-borne disease" refers to a disease caused by an infectious
microbe that is transmitted to animals by arthropods. The
arthropods, e.g., insects or arachnids, may include but are not
necessarily limited to (1) blood sucking insects such as
mosquitoes, fleas, lice, biting flies and bugs and (2) blood
sucking arachnids such as mites and ticks. The term "vector" may
refer to any arthropod that transmits a disease through feeding
activity. Herein, blood-borne pathogens may be blood-borne, vector
borne, or otherwise transferred to an animal by other intentional
and unintentional means including, for example, via transfusion of
human blood products. Herein, the term microorganism may include,
but is not necessarily limited to one or more microscopic
disease-causing organisms.
[0054] "Electromagnetic radiation," as understood by a skilled
artisan, is classified by wavelength into radio, microwave,
infrared, the visible spectrum perceived as visible light,
ultraviolet ("UV"), X-rays, and gamma rays. The phrase "radiant
energy" refers to the energy of electromagnetic waves. The phrase
"optical property" refers to any fundamental property of a material
that affects its interaction with electromagnetic energy. Optical
properties may include, but are not necessarily limited to optical
transmission, optical absorption, index of refraction,
reflectivity, non-linear effects, and scattering. The term
"transparent" can be defined to include the characterization that
no significant obstruction or absorption of electromagnetic
radiation occurs at the particular wavelength or wavelengths of
interest. Herein, the term "treatment" refers to the delivery of
electromagnetic radiation to one or more target sites of one or
more subjects. A "target site" may include one or more superficial
or surface sites and/or subsurface sites of a subject. The term
"subject" or "target subject" refers to a target entity, entities,
object or objects of the electromagnetic radiation. Exemplary
subjects may include one or more (1) inanimate objects, (2)
organisms of the three domains (Archaea, Eubacteria and Eukaryota)
and six kingdoms (Archaebacteria, Eubacteria, Protista, Fungi,
Plantae, and Animalia), (3) individual cells and cellular
components of the three domains and six kingdoms including cell
cultures, (4) blood products, (5) fluids or fluid compositions, and
combinations thereof. Suitable inanimate objects may include but
are not necessarily limited to inorganic compounds, organic
compounds, compositions thereof and articles of construction made
there from. Herein, "DNA" refers to deoxyribonucleic acid and "RNA"
refers to ribonucleic acid as understood by persons of ordinary
skill in the art of science and medicine.
[0055] The term "skin" may refer to the topical surface of members
of the Animalia kingdom. With regard to mammals, the term "skin"
refers to the epidermis and/or dermis of an animal. The epidermis
is comprised of the stratum corneum, the stratum granulosum, the
stratum spinosum, and the stratum basale, with the stratum corneum
being at the surface of the skin and the stratum basale being the
deepest portion of the epidermis. The epidermis ranges from about
0.05 mm to about 0.2 mm in thickness, depending on the location on
the body of the mammal. Beneath the epidermis is the dermis, which
is significantly thicker than the epidermis ranging from about
0.3.0 mm to about 3.0 mm in thickness, depending on the location on
the body of the mammal. The dermis is primarily composed of
collagen in the form of fibrous bundles. Herein, the term
"subcutaneous" may refer to being, living, occurring, or
administered under the skin. The term "topical" refers to any
external or outer surface locations of a target subject. The
phrases "blood vessel" and "blood vessels" may refer to veins
and/or arteries as each is understood by persons of ordinary skill
in the art of circulatory systems of animals. The term
"intravenous" may refer to being situated, performed, occurring
within, administered into, or involving entry by way of a vein. The
term "intra-arterial" may refer to being situated, performed,
occurring within, administered into, or involving entry by way of
an artery.
[0056] Herein, the phrase "hollow puncture forming member" refers
to an object operationally configured to penetrate and/or puncture
(1) inanimate material(s) and (2) dead and/or live tissue of an
animal via subcutaneous injection into veins, arteries, and other
subcutaneous areas or spaces. One suitable hollow puncture forming
member includes a cannula, as the term is understood by persons of
ordinary skill of the art of medicine. Another suitable hollow
puncture forming member includes a needle, including a hypodermic
needle as understood by persons of ordinary skill in the art of
medicine. Another suitable hollow puncture forming member includes
a catheter or flexible catheter tube. Another suitable hollow
puncture forming member includes a liquid light guide. In one
suitable embodiment, the hollow puncture forming member of the
present application is operationally configured to act as a
waveguide to convey (1) electromagnetic radiation and/or (2) one or
more fluids there through. In one implementation, fluids may
include water, saline solution or other medicinal solutions. Fluids
may also include one or more therapeutic agents including, but not
necessarily limited to hydrogen peroxide, vitamins, minerals,
pharmaceutical drugs including photo-active drugs, herbs, herbal
medicinal products, nutrients (lipids, carbohydrates, proteins),
and combinations thereof there through. In one particular
embodiment, therapeutic agents may include one or more cell
populations, such as a cell population comprising stem cells,
chemicals, compounds, chemotherapeutic agents, proteins, nucleic
acids such as DNA and RNA, other natural nucleic acids, modified
nucleic acids, DNA or nucleic acid aptamers, and combinations
thereof. In another embodiment, therapeutic agents may include a
DNA that encodes an immunogen (such as a viral antigen, like
hepatitis C virus (HCV), hepatitis B virus (HBV), human
immunodeficiency virus (HIV), influenza, Japanese encephalitis
virus (JEV), human papilloma virus (HPV), or a parasite antigen,
such as a malaria antigen, or a plant antigen, such as birch
antigen, or a bacterial antigen, such as a staphylococcal or
anthrax antigen, or a tumor antigen). As such, the hollow puncture
forming member of the present application is operationally
configured to convey or otherwise allow passage of electromagnetic
radiation and/or one or more pharmaceutically acceptable solutions
or fluids there through. Therapeutic agents of this application may
also include one or more selective release agents as desired.
[0057] Herein, "pharmaceutical drug," "drug" or "pharmaceutical"
may refer to any chemical substance intended for use in the medical
diagnosis, cure, treatment, or prevention of disease. The phrase
"herbal medicinal product" may refer to any medicinal product,
exclusively containing as active ingredients one or more herbal
substances or one or more herbal preparations, or one or more such
herbal substances in combination with one or more such herbal
preparations. The phrase "active agent" may be defined herein to
mean a therapeutic agent given to a target subject to elicit a
desired effect.
[0058] In one aspect, the application provides a waveguide and/or
waveguide assembly operationally configured to be inserted or
injected into a target subject as desired. In another embodiment,
the application provides a waveguide, including but not necessarily
limited to an injectable waveguide operationally configured to
receive and emit electromagnetic radiation there from. In still
another embodiment, the application provides a photon transmitting
waveguide including but not necessarily limited to an injectable
waveguide. In still another embodiment, the application provides a
waveguide configured to operate in a manner similar as a liquid
light guide receiving radiant energy from another waveguide such as
an optical fiber and conveying the same to a target site.
[0059] In another aspect, the application provides a device,
assembly, system and method for employing transformation optics for
the delivery of electromagnetic radiation to one or more target
sites.
[0060] In another aspect, the application provides a device,
assembly, system and method for the delivery of electromagnetic
radiation and a therapeutic amount of one or more fluids to one or
more subcutaneous target sites. The device, assembly, system may
also be operationally configured to deliver electromagnetic
radiation and a therapeutic amount of hydrogen peroxide to one or
more subcutaneous target sites. For purposes of this application,
hydrogen peroxide may be used to boost oxygen levels of a target
animal subject. In another aspect, ozone blood infusion techniques
may also be employed via the device, assembly, system and method of
this application.
[0061] In another aspect, the application provides transformation
optics for targeting electromagnetic radiation. Employing
transformation optics, a device, assembly and/or system of this
application is suitably operationally configured to convey
electromagnetic radiation to a removable hollow puncture forming
member in radiant communication thereto. In another implementation,
a device, assembly, and/or system employing transformation optics
may necessarily include a hollow puncture forming member into the
physical design of the device or assembly.
[0062] In another aspect, the application provides an injectable
parallel radiant energy forming device positioned to transform
electromagnetic radiation generated by one or more light sources
into substantially parallel beams of electromagnetic radiation. In
another aspect, the application provides an injectable collimator.
In one embodiment, the injectable collimator may be coupled to a
fiber optic cable, which in turn may be coupled to a light source.
In another aspect, the application provides an injectable liquid
light guide and collimator assembly. In another aspect, the
application provides an injectable collimator operationally
configured to collimate electromagnetic radiation received from a
waveguide or radiant conduit to a specified beam diameter or spot
size. A spot size down to a few microns may be achieved as
desired.
[0063] In another aspect, the application provides an injectable
collimator operationally configured to adjust the focal length of
the optical interface as desired, e.g., according to varying
wavelengths of electromagnetic radiation received by the
collimator.
[0064] In another aspect, the application provides a device,
assembly, system and method for the emanation of electromagnetic
radiation upon one or more targets. In another aspect, the
application provides a device, assembly, system and method for the
emanation of electromagnetic radiation to one or more blood
products housed in one or more containers--sealed and/or unsealed.
In another aspect, the application provides a device, assembly,
system and method for the emanation of electromagnetic radiation to
a target fluid housed in an open container, sealed container or
otherwise closed container. In another aspect, the application
provides a device, assembly, system and method for the emanation of
electromagnetic radiation upon one or more fluids or fluid
solutions housed in an open container or a sealed container. In
another aspect the application provides a device, assembly, system
and method operationally effective to sterilize the one or more
fluids or fluid solutions. In another aspect, the application
provides a device, assembly, system and method for the emanation of
electromagnetic radiation upon a volume of water and/or one or more
water based solutions.
[0065] In another aspect, the application provides a device,
assembly, system and method for the emanation of electromagnetic
radiation to one or more subcutaneous artificial conduits
including, but not necessarily limited to an arteriovenous ("A-V")
graft and the like. In another aspect, the application provides a
device, assembly, system and method for the emanation of
electromagnetic radiation to one or more fluid storage containers,
e.g., a bag or other container housing fluid, including but not
necessarily limited to animal fluid. Thus, it is contemplated that
the device, assembly, system and method may be used to treat blood
prior to transfusion procedures and the like, pre-surgery,
intra-surgery, post-surgery. The device, assembly, system may also
be employed to emanate electromagnetic radiation subcutaneously
pre-surgery, intra-surgery, post-surgery as desired.
[0066] In another aspect, the application provides a device,
assembly, system and method for the emanation of electromagnetic
radiation upon one or more target locations in a manner effective
to provide for non-ablating emanation of electromagnetic radiation.
In another aspect, the application provides a device, assembly,
system and method for the emanation of electromagnetic radiation
upon one or more target locations of a subject without evaporation
and/or sublimation of target material and/or target fluid of the
target subject.
[0067] In another aspect, the application provides a device,
assembly, system and method for the non-destructive emanation of
electromagnetic radiation upon one or more target locations of a
subject. In one implementation, radiant energy may be employed for
selective destruction of one or more target blood contaminants
in-vitro and/or in-vivo.
[0068] In another aspect, the application provides a device,
assembly, system and method for the emanation of electromagnetic
radiation upon one or more targets via an injectable collimator.
The collimator may include one or more inlets for receiving
electromagnetic radiation and one or more outlets for emitting
electromagnetic radiation out there from. In one embodiment, the
one or more inlets may have a larger diameter than one or more
outlets or vice versa. In another embodiment, the outlets and
inlets may be substantially equal in size. In another embodiment,
the waves of electromagnetic radiation exiting an outlet may be
narrowed. To "narrow" electromagnetic radiation may mean either to
cause the directions of motion of the electromagnetic radiation to
become more aligned in a specific direction, e.g., collimated or
parallel, or to cause the spatial cross section of the
electromagnetic radiation to become smaller.
[0069] In another aspect, the application provides a delivery
member operationally configured to guide, transmit or otherwise
convey electromagnetic radiation to one or more subsurface sites of
a target subject. In another aspect, the application provides a
waveguide operationally configured to guide or otherwise convey
transformed electromagnetic radiation to one or more subsurface
sites of a target subject. In another aspect, the application
provides a waveguide operationally configured to guide or otherwise
convey collimated electromagnetic radiation to one or more
subsurface sites of a target subject. In another aspect, the
application provides a waveguide operationally configured to guide
or otherwise convey transformed electromagnetic radiation and one
or more fluids to one or more subsurface sites of a target
subject.
[0070] In another aspect, the application provides a waveguide
operationally configured to guide, transmit or otherwise convey
electromagnetic radiation to one or more subcutaneous sites of a
target subject. In another aspect, the application provides a
waveguide operationally configured to guide, transmit or otherwise
convey transformed electromagnetic radiation to one or more
subcutaneous sites of a target subject. In another aspect, the
application provides a waveguide operationally configured to guide,
transmit or otherwise convey collimated electromagnetic radiation
to one or more subcutaneous sites of a target subject. In another
aspect, the application provides a waveguide operationally
configured to guide or otherwise convey transformed electromagnetic
radiation and one or more fluids to one or more subcutaneous sites
of a target subject.
[0071] In another aspect, the application provides a device,
assembly, system and method operationally configured for the
postoperative conveyance of electromagnetic radiation to a
subcutaneous site of a target subject and/or to a site external a
target subject including, but not necessarily limited to one or
more containers housing one or more fluids--fluids of a patient
and/or other fluids.
[0072] In another aspect, the application provides a waveguide,
waveguide assembly, or device insertable into the vascular system
of a target subject for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more vascular system
sites. In still another aspect, the application provides a
waveguide, waveguide assembly, or device insertable into the
vascular system of a target subject for guiding, transmitting or
otherwise conveying electromagnetic radiation and/or one or more
fluids to one or more vascular system sites.
[0073] In another aspect, the application provides a waveguide,
waveguide assembly, system and method for selective delivery of
electromagnetic radiation to tissue of animal at one or more
surface locations and/or subsurface locations including, but not
necessarily limited to internal tissue locations, the lumens of the
body, internal structures of animal bone, and combinations thereof.
Internal tissue locations may include intramuscular and/or internal
organ locations.
[0074] In another aspect, the application provides a waveguide,
waveguide assembly, system and method for intravenous and/or
intra-arterial emanation of electromagnetic radiation.
[0075] In another aspect, the application provides a waveguide
operationally configured to guide or otherwise convey transformed
electromagnetic radiation, including but not necessarily limited to
collimated electromagnetic radiation, to one or more target sites
of a subject.
[0076] In another aspect, the application provides a waveguide
operationally configured to provide intravenous and/or
intra-arterial delivery of transformed electromagnetic radiation.
In another aspect, the application provides a waveguide assembly
operationally configured for intravenous and/or intra-arterial
delivery of collimated electromagnetic radiation. In another
aspect, the application provides a waveguide assembly operationally
configured for intravenous and/or intra-arterial delivery of
transformed electromagnetic radiation and one or more fluids.
[0077] In another aspect, the application provides a method of
guiding electromagnetic radiation to one or more target sites of a
subject. In another aspect, the application provides a method of
guiding electromagnetic radiation to a subsurface or a subcutaneous
site of a target subject.
[0078] In another aspect, the application provides a method of
guiding or otherwise conveying collimated electromagnetic radiation
to one or more sites of a target subject. In another aspect, the
application provides a method of guiding or otherwise conveying
collimated electromagnetic radiation to one or more subsurface
and/or subcutaneous sites of a target subject.
[0079] In one aspect, the application provides a waveguide
comprising transformation optics, the waveguide being operationally
configured for intravenous and/or intra-arterial delivery of
electromagnetic radiation. In another aspect, the application
provides a device, assembly, system and method for the intravenous
and/or intra-arterial delivery of electromagnetic radiation and one
or more anti-coagulants.
[0080] In another aspect, the application provides a hypodermic
waveguide. In another aspect, the application provides a hypodermic
waveguide assembly. In another aspect, the application provides a
hypodermic liquid light guide.
[0081] In another aspect, the application provides a waveguide
operationally configured to penetrate a target subject for guiding
or otherwise conveying electromagnetic radiation to a penetrated
site within a target subject. In another aspect, the application
provides a waveguide assembly operationally configured to penetrate
a target subject for guiding or otherwise conveying electromagnetic
radiation to a penetrated site within a target subject. In another
aspect, the application provides a system including a delivery
member operationally configured to penetrate a target subject for
guiding or otherwise conveying electromagnetic radiation to a
penetrated site within a target subject.
[0082] In another aspect, the application provides a waveguide
operationally configured to guide or otherwise convey
electromagnetic radiation into a target subject. In another aspect,
the application provides a waveguide assembly operationally
configured to guide or otherwise convey electromagnetic radiation
into a target subject. In another aspect, the application provides
a system including a waveguide device or assembly comprising
transformation optics, the waveguide device or assembly being
operationally configured to guide or otherwise convey
electromagnetic radiation to or into a target subject.
[0083] In another aspect, the application provides a waveguide
device or assembly including transformation optics and a penetrable
liquid light guide operationally configured to guide or otherwise
convey electromagnetic radiation and one or more fluids to one or
more sites of a target subject. In another aspect, the application
provides a system including a waveguide assembly including
transformation optics and a penetrable liquid light guide
operationally configured to guide or otherwise convey
electromagnetic radiation received from one or more sources and one
or more fluids received from one or more sources to one or more
sites of a target subject.
[0084] In another aspect, the application provides an assembly
including transformation optics operationally, the assembly being
configured to convey electromagnetic radiation to one or more
subsurface sites of a target subject. In another aspect, the
application provides an assembly including transformation optics,
the assembly being operationally configured to convey
electromagnetic radiation to one or more subcutaneous sites of a
target subject.
[0085] In one aspect, the application provides a liquid light guide
assembly operationally configured to receive radiant energy and one
or more fluids and deliver radiant energy and fluids to a target
site of subject. In one aspect, the application provides a liquid
light guide assembly operationally configured to receive radiant
energy and one or more fluids and deliver radiant energy and fluids
to a subcutaneous site of subject.
[0086] In one aspect, the application provides a waveguide assembly
for injecting electromagnetic radiation and/or one or more fluids
into a target subject. In another aspect, the application provides
a waveguide for injecting electromagnetic radiation and/or one or
more therapeutic agents into a target subject.
[0087] In one aspect, the application provides a device, assembly,
system and method for guiding, transmitting, or otherwise conveying
electromagnetic radiation received from a source of electromagnetic
radiation to a target site--the device and/or assembly being
operationally configured to transform the electromagnetic radiation
received from the source. The source of electromagnetic radiation
is operationally configured to produce radiation across the entire
electromagnetic spectrum.
[0088] In one aspect, the application provides a device, assembly,
system and method for guiding, transmitting, or otherwise conveying
electromagnetic radiation in the optical spectrum to one or more
target sites.
[0089] In one aspect, the application provides a device, assembly,
system and method for transforming electromagnetic radiation prior
to the electromagnetic radiation reaching one or more target
sites.
[0090] In one aspect, the application provides a device, assembly,
system and method for conveying electromagnetic radiation to one or
more target sites of a subject. In one simplified implementation,
the application provides a device operationally configured to
receive electromagnetic radiation at an inlet and convey the
electromagnetic radiation out through an outlet, the device being
operationally configured to transform, manipulate or otherwise
affect the electromagnetic radiation prior to its exiting out
through the outlet.
[0091] In another aspect, the application provides a device,
assembly, system and method for conveying electromagnetic radiation
from one or more waveguides through one or more optical interfaces
prior to the electromagnetic radiation being conveyed out through a
hollow member to one or more target sites of a subject.
[0092] In another aspect, the application provides a device,
assembly, system and method for conveying electromagnetic radiation
from one or more waveguides through one or more optical interfaces
prior to the electromagnetic radiation being conveyed out through a
hollow member to a target site of a subject. In another aspect, the
application provides a device, assembly, system and method for
conveying electromagnetic radiation from one or more waveguides
through one or more optical interfaces prior to the electromagnetic
radiation being conveyed out through a hollow puncture forming
member to a target site of a subject.
[0093] In another aspect, the application provides a device,
assembly, system and method for conveying electromagnetic radiation
to one or more subcutaneous sites of a subject.
[0094] In another aspect, the application provides a device,
assembly, system and method for conveying electromagnetic radiation
to one or more dermal sites of a subject.
[0095] In another aspect, the application provides a device,
assembly, system and method for conveying electromagnetic radiation
to one or more epidermal sites of a subject.
[0096] In another aspect, the application provides a device,
assembly, system and method for conveying electromagnetic radiation
to one or more topical sites of a subject.
[0097] In another aspect, the application provides a device,
assembly, system and method for collective targeting of organisms
including a host organism and one or more parasite organisms with
electromagnetic radiation. In another aspect, the application
provides a liquid light guide assembly for collective targeting of
organisms including a host organism and one or more parasite
organisms with electromagnetic radiation.
[0098] In another aspect, the application provides a device, system
and method for collective targeting of organisms including a host
organism and one or more mutual or commensal symbionts with
electromagnetic radiation. In another aspect, the application
provides a liquid light guide assembly for collective targeting of
organisms including a host organism and one or more mutual or
commensal symbionts with electromagnetic radiation.
[0099] In another aspect, the application provides a device,
assembly, system and method for collective targeting of two or more
organisms on or within a host organism with electromagnetic
radiation.
[0100] In another aspect, the application provides a device,
assembly, system and method for conveying electromagnetic radiation
to one or more subsurface sites of a subject.
[0101] In another aspect, the application provides a device,
assembly, system and method for conveying electromagnetic radiation
to one or more subcutaneous sites of a subject. In particular, one
or more sources of electromagnetic radiation and one or more
sources of one or more fluids or fluid solutions, each of which is
in communication with one or more hollow members or hollow tubular
members operationally configured to convey the electromagnetic
radiation and fluid to one or more target sites, e.g., subcutaneous
sites. In the device, assembly and hollow member or hollow tubular
member, the fluid acts as an electromagnetic waveguide for the
electromagnetic radiation propagating there through. In one
embodiment, the hollow member or hollow puncture forming member has
a high index core surrounded by a low index, i.e., index of
refraction, cladding. In such embodiment, the one or more fluid or
fluid solutions employed, e.g., a saline solution, acts as the core
and the hollow member acts as the cladding as the terms are
understood in the art of waveguides. It is also contemplated that
the hollow member or hollow puncture forming member discussed
herein includes one or more coatings on the inner surfaces there
through to affect conveyance of the electromagnetic radiation
and/or fluid as desired.
[0102] In another aspect, the application provides a system for
conveying one or more frequencies of electromagnetic radiation, the
system including one or more sources of electromagnetic radiation
and one or more sources of one or more fluids, each of which is in
communication with a hollow puncture forming member operationally
configured for subcutaneous injection into a target subject. In
another embodiment, the system may include one or more therapeutic
agents. In another embodiment, the system may include one or more
photo-active drugs.
[0103] In another aspect, the application provides a device,
assembly, system and method for conveying electromagnetic radiation
from one or more waveguides through one or more optical interfaces
and a hollow puncture forming member to a subcutaneous location
within an animal.
[0104] In another aspect, the application provides a device,
assembly, system and method for substantially transforming
electromagnetic radiation.
[0105] In another aspect, the application provides a device,
assembly, system and method for substantially narrowing
electromagnetic radiation.
[0106] In another aspect, the application provides a device,
assembly, system and method for substantially collimating
electromagnetic radiation.
[0107] In another aspect, the application provides a device,
assembly, system and method for substantially transforming
electromagnetic radiation for intravenous and/or intra-arterial
use.
[0108] In another aspect, the application provides a device,
assembly, system and method for substantially collimating
electromagnetic radiation for intravenous and/or intra-arterial
use.
[0109] In another aspect, the application provides a device,
assembly, system and method for substantially transforming beams of
light for intravenous use and/or intra-arterial.
[0110] In another aspect, the application provides a device,
assembly, system and method for substantially collimating beams of
light for intravenous use and/or intra-arterial.
[0111] In another aspect, the application provides a device,
assembly, system and method for transmitting collimated
electromagnetic radiation through one or more hollow puncture
forming members. In another aspect, the application provides a
device, assembly, system and method for transmitting collimated
electromagnetic radiation and fluid through one or more hollow
puncture forming members.
[0112] In another aspect, the application provides a device,
assembly, system and method for transmitting transformed light
through one or more hollow puncture forming members. In another
aspect, the application provides a device, assembly, system and
method for transmitting transformed light and fluid through one or
more hollow puncture forming members.
[0113] In another aspect, the application provides a device,
assembly, system and method for transmitting collimated light
through one or more hollow members or hollow puncture forming
members. In another aspect, the application provides a device,
assembly, system and method for transmitting collimated light and
fluid through one or more hollow members or hollow puncture forming
members.
[0114] In another aspect, the application provides a device,
assembly, system and method for transmitting collimated
electromagnetic radiation through one or more hollow members or
hollow puncture forming members into a blood vessel of a target
subject.
[0115] In another aspect, the application provides a device,
assembly, system and method for emanating a target subject with
collimated electromagnetic radiation.
[0116] In another aspect, the application provides a device,
assembly, system and method for guiding, transferring or otherwise
conveying collimated light through one or more hollow puncture
forming members into a blood vessel of a target subject.
[0117] In another aspect, the application provides a collimator for
transmitting electromagnetic radiation through one or more hollow
puncture forming members in communication therewith. In another
aspect, the application provides a collimator for transmitting
electromagnetic radiation through a liquid light guide in
communication therewith.
[0118] In another aspect, the application provides a collimator for
transmitting electromagnetic radiation through one or more hollow
puncture forming members into a blood vessel of a subject. In
another aspect, the application provides a collimator for
transmitting electromagnetic radiation through a liquid light guide
in communication with the collimator into a blood vessel of a
subject.
[0119] In another aspect, the application provides a system and
method for transmitting electromagnetic radiation to one or more
subcutaneous sites of a target animal subject. The system and
method include a waveguide for conveying radiant energy from a
source of radiant energy to a device or assembly in communication
with a hollow member, including but not necessarily limited to a
hollow puncture forming member. The device or assembly is
operationally configured to isolate or otherwise fluidly seal the
waveguide from the hollow member and any fluid delivered to the
device or assembly as well as any bodily fluid or tissue of a
subject. Thus, it is contemplated that a waveguide, e.g., an
optical fiber, free from contamination may be reused as
desired.
[0120] In another aspect, the application provides a device,
assembly, system and method for targeting a subject with
transformed electromagnetic radiation. In another aspect, the
application provides a device, assembly, system and method for
targeting a subject with collimated electromagnetic radiation. In
one implementation, the device or assembly is operationally
configured to receive electromagnetic radiation and fluid therein
and convey the electromagnetic radiation and fluid out from the
device or assembly. In another implementation, the device or
assembly is operationally configured to receive electromagnetic
radiation and fluid therein and convey the electromagnetic
radiation and fluid out from the device or assembly through a
common outlet. In one particular embodiment, the device or assembly
includes a transparent fluid barrier. In another particular
embodiment, the device or assembly includes a transparent fluid
barrier disposed between a waveguide in radiant communication with
the device or assembly and a hollow member in radiant and fluid
communication with device or assembly.
[0121] In another aspect, the application provides an optical
device or assembly operationally configured to transmit transformed
electromagnetic radiation there through, the transformed
electromagnetic radiation being deliverable to one or more target
sites external the device.
[0122] In another aspect, the application provides an optical
device or assembly operationally configured to transmit transformed
electromagnetic radiation through one or more hollow puncture
forming members attached thereto.
[0123] In another aspect, the application provides a device
including a lens, the device being operationally configured to
transmit transformed electromagnetic radiation through one or more
hollow puncture forming members attached thereto. In another
aspect, the application provides a device including a lens, the
device being operationally configured to transmit collimated
electromagnetic radiation through one or more hollow puncture
forming members attached thereto.
[0124] In another aspect, the application provides a device or
assembly for receiving (1) one or more electromagnetic radiation
waveguides at a first end and (2) a hollow puncture forming member
at a second end; the device being operationally configured to
convey electromagnetic radiation received from the one or more
waveguides out through the hollow puncture forming member. In
another aspect, the application provides a device or assembly for
receiving (1) one or more electromagnetic radiation waveguides at a
first inlet, (2) a fluid stream at a second inlet and (3) a hollow
puncture forming member at a first outlet, the device being
operationally configured to convey electromagnetic radiation
received from the one or more waveguides and fluid out through the
hollow puncture forming member--the fluid acting as an
electromagnetic waveguide for the electromagnetic radiation
propagating through the hollow puncture forming member.
[0125] In another aspect, the application provides a device or
assembly operationally configured to receive one or more
electromagnetic radiation waveguides at a first end, the device or
assembly being operationally configured to convey electromagnetic
radiation received from the one or more waveguides out through an
aperture of the device. In another aspect, the application provides
a device or assembly operationally configured to receive one or
more electromagnetic radiation waveguides at a first inlet and
fluid at a second inlet, the device or assembly being operationally
configured to convey electromagnetic radiation received from the
one or more waveguides and fluid out through an aperture of the
device or assembly.
[0126] In another aspect, the application provides a device or
assembly for receiving (1) one or more electromagnetic radiation
waveguides at a first end and (2) a hollow puncture forming member
at a second end; the device or assembly being operationally
configured to narrow electromagnetic radiation received from the
waveguides and convey the same out through the hollow puncture
forming member.
[0127] In another aspect, the application provides a device or
assembly for receiving (1) one or more electromagnetic radiation
waveguides at a first end and (2) a hollow puncture forming member
at a second end; the device or assembly being operationally
configured to collimate electromagnetic radiation received from the
waveguides and convey the same out through the hollow puncture
forming member.
[0128] In another aspect, the application provides a device or
assembly releasably attachable to an optical waveguide at a first
end and a hollow puncture forming member at a second end, wherein
the device or assembly is constructed from one or more materials
operationally configured to transform, e.g., collimate,
electromagnetic radiation received from the optical waveguide, the
transformed electromagnetic radiation being conveyed out through
the hollow puncture forming member.
[0129] In another aspect, the application provides a device or
assembly releasably attachable to an optical fiber at a first end
and releasably attachable to a hypodermic needle at a second end,
wherein the device or assembly is constructed from one or more
materials operationally configured to collimate electromagnetic
radiation received from the optical fiber and convey the collimated
electromagnetic radiation out through the needle; wherein the
optical fiber is set apart from or otherwise isolated from the
needle.
[0130] In another aspect, the application provides a device or
assembly releasably attachable to an optical fiber at a first
inlet, releasably attachable to a fluid conduit at a second inlet
and releasably attachable to a hypodermic needle at a first outlet.
The device or assembly operationally configured to transform
electromagnetic radiation received from the optical fiber by
employing transformation optics, the transformed electromagnetic
radiation being conveyed out of the needle; wherein the optical
fiber is set apart from or otherwise isolated from the needle, at
least in part, via the transformation optics.
[0131] In another aspect, the application provides a system and
method for transmitting electromagnetic radiation to an intravenous
or intra-arterial site, the system including one or more saline
solution sources, one or more electromagnetic radiation sources,
one or more waveguides in communication with the electromagnetic
radiation sources, a collimator and a hollow member or hollow
puncture forming member in optical communication with the
collimator; wherein the collimator is operationally configured to
apply a transform to the electromagnetic radiation received from
the one or more waveguides, the transformed electromagnetic
radiation being conveyable out through the hollow puncture forming
member attached thereto.
[0132] In another aspect, the application provides a disposable
device for conveying or otherwise directing electromagnetic
radiation to a target site including, but not necessarily limited
to a subsurface site, subcutaneous site, and combinations
thereof.
[0133] In another aspect, the application provides a reusable
device for conveying or otherwise directing electromagnetic
radiation to a target site including, but not necessarily limited
to a subsurface site, subcutaneous site, and combinations
thereof.
[0134] In another aspect, the application provides a system for
transmitting electromagnetic radiation to a target site such as a
topical, subsurface or subcutaneous site, including communicating
to an operator of the system the frequency of the electromagnetic
radiation being conveyed to the site.
[0135] In another aspect, the application provides an assembly for
transmitting electromagnetic radiation to a subcutaneous site
including a hollow puncture forming member having a reflective
inner surface.
[0136] In another aspect, the application provides a system
including an assembly operationally configured to simultaneously
convey electromagnetic radiation and one or more parenteral
substances to a subcutaneous site.
[0137] In another aspect, the application provides a device for
receiving (1) one or more optical fibers at a first end, and (2) a
hypodermic needle at a second end; the device being operationally
configured to collimate the electromagnetic radiation received from
the one or more optical fibers and direct the collimated
electromagnetic radiation out through the hypodermic needle.
[0138] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating one or
more blood contaminants of a subject with electromagnetic
radiation.
[0139] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating one or
more blood disorders of a subject with electromagnetic
radiation.
[0140] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating one or
more blood diseases of a subject with electromagnetic
radiation.
[0141] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating one or
more blood infections of a subject with electromagnetic
radiation.
[0142] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating one or
more infectious diseases of a subject with electromagnetic
radiation. In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating one or
more infectious diseases of a subject with transformed
electromagnetic radiation.
[0143] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating one or
more emerging infectious diseases of a subject with electromagnetic
radiation. In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating one or
more emerging infectious diseases of a subject with transformed
electromagnetic radiation.
[0144] In another aspect, the application provides a device,
assembly, system and method for treating and/or treating one or
more blood cancers of a subject with electromagnetic radiation.
[0145] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating one or
more blood-borne pathogens of a subject with electromagnetic
radiation.
[0146] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating malaria
with electromagnetic radiation.
[0147] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating syphilis
with electromagnetic radiation.
[0148] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating
brucellosis with electromagnetic radiation.
[0149] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating Hepatitis
A with electromagnetic radiation.
[0150] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating Hepatitis
B with electromagnetic radiation.
[0151] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating Hepatitis
C with electromagnetic radiation.
[0152] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating Hepatitis
D with electromagnetic radiation.
[0153] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating Hepatitis
E with electromagnetic radiation.
[0154] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating Hepatitis
X with electromagnetic radiation.
[0155] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating Hepatitis
G with electromagnetic radiation.
[0156] In another aspect, the application provides a device,
assembly, system and method for targeting Human Immunodeficiency
Virus ("HIV") with electromagnetic radiation. As understood by
skilled artisans, HIV may include a retrovirus or group of
retroviruses denominated "HIV", "HIV-1," "HIV-2," "HIV-3" and
"HIV-4." The most common cause of AIDS is thought to be HTLV-III,
typically referred to as HIV-1.
[0157] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating one or
more RNA viruses (as the term is understood by the skilled artisan)
with electromagnetic radiation.
[0158] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating viral
hemorrhagic fever with electromagnetic radiation.
[0159] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating ebola
virus disease ("EVD") with electromagnetic radiation.
[0160] In another aspect, the application provides a device,
assembly, system and method for targeting and/or treating one or
more blood contaminants, one or more blood disorders, one or more
blood diseases, one or more blood infections, one or more
infectious diseases, one or more emerging infectious diseases, one
or more blood cancers, one or more pathogens, one or more blood
products, one or more blood contaminants with electromagnetic
radiation and intravenous therapy.
[0161] In another aspect, the application provides a system and
method for adjusting or otherwise altering the electromagnetic
radiation and/or the duration of treatment of one or more blood
contaminants, one or more blood disorders, one or more blood
diseases, one or more blood infections, one or more infectious
diseases, one or more emerging infectious diseases, one or more
blood cancers, one or more pathogens, one or more blood products,
one or more blood contaminants with electromagnetic radiation.
[0162] In another aspect, the application provides an apparatus
operationally configured to generate selected wavelengths of
electromagnetic radiation at a selected power level for a specified
duration of time, the electromagnetic radiation being conveyable to
one or more surface and/or subsurface target sites of a
subject.
[0163] In another aspect, the application provides a system and
method operationally configured to generate selectable wavelengths
of light at a selected power level for a specified duration of
time, the light being conveyable to one or more surface and/or
subsurface target sites of a subject via the system.
[0164] In another aspect, the application provides a system and
method operationally configured to generate and deliver selectable
wavelengths of electromagnetic radiation at user selectable power
levels to one or more surface and/or subsurface target sites of a
subject.
[0165] In another aspect, the application provides a system and
method operationally configured to generate and deliver selectable
wavelengths of light at user selectable power levels to one or more
surface and/or subsurface target sites of a subject.
[0166] In another aspect, the application provides a system and
method operationally configured to generate selectable wavelengths
of electromagnetic radiation at user selectable power levels, the
system including a puncture forming device operationally configured
to convey the electromagnetic radiation to a surface and/or
subsurface target site of a subject.
[0167] In another aspect, the application provides a device or
assembly for receiving (1) one or more electromagnetic radiation
waveguides at a first end and (2) a hollow puncture forming member
at a second end; the device or assembly being operationally
configured to transform electromagnetic radiation received from the
one or more waveguides and convey the same out through the hollow
puncture forming member, the device or assembly being operationally
configured to isolate the one or more electromagnetic radiation
waveguides apart from the hollow puncture forming member.
[0168] In another aspect, the application provides a device or
assembly for receiving (1) one or more electromagnetic radiation
waveguides at a first end and (2) a hollow puncture forming member
at a second end; the device or assembly being operationally
configured to transform electromagnetic radiation received from the
one or more waveguides and convey the electromagnetic radiation out
through the hollow puncture forming member, the device or assembly
being operationally configured to isolate the one or more
electromagnetic radiation waveguides apart from an open tip of the
hollow puncture forming member.
[0169] In another aspect, the application provides a device or
assembly for receiving (1) one or more electromagnetic radiation
waveguides at a first end and (2) a hollow puncture forming member
at a second end; the device or assembly being operationally
configured to collimate electromagnetic radiation received from the
one or more waveguides and convey the electromagnetic radiation out
through the hollow puncture forming member, the device or assembly
being operationally configured to isolate the one or more
electromagnetic radiation waveguides apart from an open tip of the
hollow puncture forming member.
[0170] In another aspect, the application provides a device or
assembly for receiving (1) one or more optical fibers at a first
location, (2) one or more fluids at one or more second locations
and (3) a needle at a third location; the device or assembly being
operationally configured to collimate electromagnetic radiation
received from the one or more optical fibers and convey the
collimated electromagnetic radiation and fluid out through the
needle, the device or assembly being operationally configured to
isolate the one or more optical fibers apart from the needle and
fluid within the device or assembly.
[0171] In another aspect, the application provides a device or
assembly for receiving (1) one or more optical fibers at a first
location, (2) one or more fluids at one or more second locations
and (3) a hypodermic needle at a third location; the device or
assembly being operationally configured to collimate
electromagnetic radiation received from the one or more optical
fibers and convey the collimated electromagnetic radiation and
fluid out through the needle, the device or assembly being
operationally configured to isolate the one or more optical fibers
apart from an open tip of the needle and fluid within the device or
assembly.
[0172] In another aspect, the application provides a system
operationally configured to guide or otherwise convey
electromagnetic radiation from one or more sources of
electromagnetic radiation to one or more target sites, the system
including one or more sources of electromagnetic radiation, one or
more optical interfaces in communication with the one or more
sources of electromagnetic radiation, and one or more delivery
devices in communication with the one or more optical interfaces
for conveying electromagnetic radiation to one or more target
sites. The system may further include one or more fluid sources.
The system may be operationally configured to convey fluid and
electromagnetic radiation out of a common outlet of the device. For
example, the system may be operationally configured to convey fluid
and electromagnetic radiation out from the device to one or more
target sites.
[0173] In another aspect, the application provides a system
operationally configured to guide or otherwise convey
electromagnetic radiation to one or more target sites, the system
including at least one or more sources of electromagnetic
radiation, one or more waveguides in communication with the one or
more sources of electromagnetic radiation, one or more optical
interfaces in communication with the one or more waveguides, and
one or more delivery devices in communication with the one or more
optical interfaces for conveying electromagnetic radiation to one
or more target sites. The system may further include one or more
fluid sources. The system may be operationally configured to convey
fluid and electromagnetic radiation out from the device.
[0174] In another aspect, the application provides a system
operationally configured to guide or otherwise convey
electromagnetic radiation to one or more target sites, the system
including at least one or more sources of electromagnetic
radiation, one or more waveguides in communication with the one or
more sources of electromagnetic radiation, the one or more
waveguides being provided with one or more optical interfaces, and
one or more delivery devices in communication with the one or more
waveguides for conveying electromagnetic radiation to one or more
target sites. The system may further include one or more fluid
sources. The system may be operationally configured to convey fluid
and electromagnetic radiation out from the device. The system may
be operationally configured to convey fluid and electromagnetic
radiation out from the device to one or more target sites.
[0175] In another aspect, the application provides a system
operationally configured to guide or otherwise convey
electromagnetic radiation to one or more target sites, the system
including at least one or more sources of electromagnetic
radiation, one or more waveguides in communication with the one or
more sources of electromagnetic radiation, and one or more delivery
devices provided with optical interfaces, whereby the delivery
devices are in communication with the one or more waveguides and
operationally configured to convey electromagnetic radiation to one
or more target sites. The system may further include one or more
fluid sources. The system may be operationally configured to convey
fluid and electromagnetic radiation out from the device. The system
may be operationally configured to convey fluid and electromagnetic
radiation out from the device to one or more target sites.
[0176] In another embodiment, the application provides a device or
assembly having one or more sources of electromagnetic radiation,
one or more optical interfaces, and one or more outlets for
conveyance of electromagnetic radiation to one or more target
sites.
[0177] In another embodiment, the application provides a device or
assembly having one or more sources of electromagnetic radiation,
one or more sources of fluid, one or more optical interfaces, and
one or more outlets for conveyance of electromagnetic radiation and
fluid. The device may include a self contained power source for
powering the one or more sources of electromagnetic radiation. Or,
in the alternative, the one or more sources of electromagnetic
radiation may be powered via an external source.
[0178] In another embodiment, the application provides a device or
assembly including a hollow puncture forming member comprised of
one or more non-absorbent materials.
[0179] In another embodiment, the application provides a device or
assembly including a hollow puncture forming member including an
inner surface comprised of one or more non-absorbent materials.
[0180] In another embodiment, the application provides a device or
assembly including a metal hollow puncture forming member including
an inner surface comprised one or more non-absorbent materials.
[0181] In another embodiment, the application provides a device or
assembly including a plastic hollow puncture forming member
comprised of one or more non-absorbent materials.
[0182] In another embodiment, the application provides a device or
assembly including a plastic puncture forming member including an
inner surface comprised of one or more non-absorbent materials.
[0183] In another embodiment, the application provides a device or
assembly including a hollow puncture forming member constructed
from one or more composite materials, the hollow puncture forming
member including an inner surface comprised of one or more
non-absorbent materials.
[0184] In another embodiment, the application provides a device or
assembly including a hollow puncture forming member constructed
from silicone, the hollow puncture forming member including an
inner surface comprised of one or more non-absorbent materials.
[0185] In another embodiment, the application provides a device or
assembly including a cannulation technique for intravenous and/or
intra-arterial conveyance of electromagnetic radiation.
[0186] In another embodiment, the application provides a device or
assembly including a hollow member or a hollow puncture forming
member defined by an inner surface of total internal reflection. In
another embodiment, the application provides a device or assembly
having an outlet for electromagnetic radiation and/or fluid defined
by an inner surface of total internal reflection.
[0187] In another embodiment, the application provides a hollow
puncture forming member substantially bonded to an inner optical
fiber.
[0188] In another embodiment, the application provides a device,
assembly, system, and method for irradiation of blood using
electromagnetic radiation. The blood may belong to a single person
or animal or multiple persons or animals when treating blood housed
in one or more containers.
[0189] In another embodiment, the application provides a device,
assembly, system, and method for radiant energy blood irradiation
in vivo and/or in vitro.
[0190] In another embodiment, the application provides a device,
assembly, system, and method for extracorporeal targeting of animal
fluid using electromagnetic radiation. In another embodiment, the
application provides a device, assembly, system, and method for
extracorporeal targeting and intravenous and/or intra-arterial
targeting of animal fluid using electromagnetic radiation.
[0191] In another embodiment, the application provides a device,
assembly, system, and method incorporating an extracorporeal
circuit and an injectable waveguide operationally configured to
emit electromagnetic radiation there from. In one aspect, the
extracorporeal circuit and injectable waveguide are operationally
configured to target animal fluid using electromagnetic radiation.
In one embodiment, the injectable waveguide is suitable effective
as a liquid light guide in operation.
[0192] In another aspect, the application provides a device or
assembly for transmitting electromagnetic radiation out there from
to a surface location and/or a subsurface location including, but
not necessarily limited to a subcutaneous site, the device or
assembly including a hollow puncture forming member having a
reflective inner surface. In one embodiment, the hollow puncture
forming member may be formed from one or more materials
operationally configured to be shaped into a desired form. In
another embodiment, the hollow puncture forming member may be
formed from one or more resins and/or one or more polyresins
operationally configured to be shaped into a desired form.
[0193] In another aspect, the application provides a device or
assembly for transmitting electromagnetic radiation to a surface
location and/or a subsurface location of a target subject
including, but not necessarily limited to a subcutaneous site, the
device including a hollow puncture forming member joined to an
optical fiber housed therein.
[0194] In another aspect, the application provides a device,
assembly, system and method of photoluminescence, as the term is
understood by the skilled artisan. The system may include a source
of electromagnetic radiation whereby the radiation output of the
source may be adjusted according to one or more parameters
including, but not necessarily limited to the electromagnetic
spectrum of a target subject. The system is operationally
configured to convey electromagnetic radiation from the source to a
device or assembly for conveying the electromagnetic radiation to
one or more target sites of the subject.
[0195] In another aspect, the application provides a device,
assembly, system and method of hemo-irradiation, as the term is
understood by the skilled artisan.
[0196] In another aspect, the application provides a device,
assembly, system and method of photopheresis, as the term is
understood by the skilled artisan.
[0197] In another aspect, the application provides a device,
assembly, system and method of photochemotherapy, as the term is
understood by the skilled artisan.
[0198] In another aspect, the application provides a device,
assembly, system and method of photobiological therapy, as the
phrase is understood by the skilled artisan.
[0199] In another aspect, the application provides a device,
assembly, system and method of photo-oxidation, as the term is
understood by the skilled artisan.
[0200] In another aspect, the application provides a device,
assembly, system and method of ultraviolet blood irradiation, as
the phrase is understood by the skilled artisan.
[0201] In another aspect, the application provides a device,
assembly, system and method of photodynamic therapy, as the phrase
is understood by the skilled artisan.
[0202] In another aspect, the application provides a method of
exposing animal blood to electromagnetic radiation.
[0203] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
a subject in a manner effective to inactivate blood contaminants of
the subject.
[0204] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
a subject in a manner effective to inactivate toxins and viruses of
the subject.
[0205] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
a subject in a manner effective to destroy and/or inhibit viruses
of the subject.
[0206] In another aspect, the application provides a device, system
and method for guiding, transmitting or otherwise conveying
electromagnetic radiation to one or more target sites of a subject
in a manner effective to destroy and/or inhibit the growth of
bacteria of the subject.
[0207] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
a subject in a manner effective to kill pathogens in the
bloodstream of the subject, the duration of exposure of the blood
to electromagnetic radiation being less than the duration required
to kill the same pathogens outside of the subject, e.g., the
targeting of pathogens in a laboratory setting.
[0208] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
a subject in a manner effective to destroy and/or inhibit the
growth of fungi of the subject.
[0209] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject in a manner effective to increase the
oxygen-combining power of the blood of the subject.
[0210] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject in a manner effective to activate steroid
hormones of the subject.
[0211] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject in a manner effective to increase cell
permeability of the subject.
[0212] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject in a manner effective for the blood of the
subject to continue emanating secondary radiation following
treatment.
[0213] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject in a manner effective to cause vasodilation.
[0214] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject in a manner effective to activate white blood
cells of the subject.
[0215] In another aspect, the application provides a device, system
and method for guiding, transmitting or otherwise conveying
electromagnetic radiation to one or more target sites of an animal
subject in a manner effective to decrease platelet aggregation of
the subject.
[0216] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject in a manner effective to stimulate fibrinolysis
of the subject.
[0217] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject in a manner effective to decrease the viscosity
of blood of the subject.
[0218] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject in a manner effective to stimulate corticosteroid
production of the subject.
[0219] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject in a manner effective to improve or increase
microcirculation of the subject.
[0220] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject whereby multiple treatments of a subject has
cumulative physiological and/or therapeutic effects.
[0221] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject in a manner effective to restore normal chemical
balances of the subject.
[0222] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject in a manner effective to enhance local and
systemic resistance of the subject.
[0223] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites of
an animal subject in a manner effective to damage the DNA inside
target cells making the cells unable to divide and reproduce.
[0224] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to the blood of an animal
subject in a manner effective to cause the hemoglobin to absorb the
electromagnetic radiation.
[0225] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to the blood of an animal
subject in a manner effective to produce an autogeneous
vaccine.
[0226] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to capillaries of one or more
target subjects.
[0227] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to the blood of an animal
subject in a manner effective to increase vitamin D content and/or
cholesterol in the blood plasma of the subject.
[0228] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to the blood of an animal
subject in a manner effective to increase oxygen absorption by the
blood of the subject.
[0229] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to the blood of an animal
subject for treating ultraviolet-light deficiency as understood by
the skilled artisan.
[0230] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to the blood of an animal
subject for producing one or more photo-chemical reactions.
[0231] In another aspect, the application provides an
electromagnetic radiation source, a radiation conduit, a source of
one or more therapeutic agents and a device in communication with
the radiation source and the therapeutic agent source that is
operationally configured to direct electromagnetic radiation and
one or more therapeutic agents to a target site such as a
subcutaneous site of an animal. In this embodiment, one or more of
(1) the intensity of the electromagnetic radiation, (2) the
wavelength of the spectral energy used and (3) the duration of
exposure may be determined according to (a) the absorption
characteristics of the one or more blood contaminants targeted for
exposure to the electromagnetic radiation, (b) as necessary to
produce a desired photo-chemical change in the animal.
[0232] In another aspect, the application provides a device,
assembly, system and method for treating and/or filtering and/or
purifying one or more fluids to be conveyed from a source to a
target site. Thus, in one aspect, the device, assembly and system
may be operationally configured to treat one or more fluids via
mechanical treatment and/or radiant energy targeting.
[0233] In another aspect, the application provides a device,
assembly, system and method for treating and/or adding one or more
components to fluid being conveyed to a target site.
[0234] In another aspect, the application provides a device,
assembly, system and method for guiding, transmitting or otherwise
conveying electromagnetic radiation to one or more target sites
making use of radio-frequency identification ("RFID") technology
(often referred to as RFID tags) to ensure that only approved
component parts may be used as part of the system. In other words,
if the correct data is not transmitted according to the required
RFID, then one or more component parts including the source of
electromagnetic radiation, waveguide, device or assembly may not be
operable. Such identification measures may support
anti-counterfeiting, provide tamper proofing of the device,
assemblies and system herein, protect against the manufacturing and
sale of unendorsed copycat component parts, electronics or other
items. Likewise, it also contemplated that one or more system
components may be given a unique serial number. An electromagnetic
radiation source may be calibrated according to the hollow puncture
forming member identified for use in one or more particular
treatments. Thus, an antenna may be used near an optical fiber whip
operationally configured to read a tag encrypted code as desired.
In other embodiments, image based technology may be employed as
understood by the skilled artisan. In one embodiment, QR Code
technology may be employed as desired.
[0235] In another aspect, the application provides a device,
assembly, system and method operationally configured to convey
fluid and electromagnetic radiation to one or more target sites. In
particular, a source of electromagnetic radiation may be
operationally configured to produce electromagnetic radiation of a
particular wavelength and amplitude. In one aspect, the wavelength
and amplitude of the electromagnetic radiation may be substantially
maintained throughout the system. In another aspect, the wavelength
and amplitude of the electromagnetic radiation may be altered via
one or more mechanical means. In another aspect, a wavelength and
amplitude of radiant energy generated by the source of
electromagnetic radiation at any given moment may be determined or
otherwise calculated in a manner effective to emit a particular
wavelength and amplitude of radiant energy to a target site
according to one or more variables or parameters including, but not
necessarily limited to the index of refraction and/or total
internal reflection and/or numerical aperture and/or various
absorption properties and/or scattering properties of any
waveguides, optical interfaces and hollow puncture forming members
employed, the compression of radiant energy during the transition
from one waveguide into another waveguide of smaller cross section,
the index of refraction and/or absorption properties and/or
scattering properties of fluids used, and combinations thereof.
[0236] In another aspect, the application provides a system
including a radiant energy source programmable as desired, a
waveguide in radiant communication with the source, a
transformation hub for receiving the waveguide in communication
therewith and for transforming radiant energy received via the
waveguide, a fluid housing in radiant communication with the
transformation hub and in fluid communication with one or more
fluid sources, and a hollow puncture forming member in radiant
communication and fluid communication with the fluid housing.
[0237] In another aspect, the application provides for the
transformation of electromagnetic waves via transformation optics
at a point between a source of electromagnetic radiation and a
target of the electromagnetic radiation. The application suitably
provides transformation optics set apart from a hollow puncture
forming member operationally configured to deliver electromagnetic
radiation to a target.
[0238] In another aspect, the application provides a device or
assembly comprising transformation optics for transforming
electromagnetic radiation in a manner best suited for conveyance of
the electromagnetic radiation through a hollow member in radiant
communication with the device or assembly. It is also contemplated
that the transformation may comprise attenuation of undesirable
frequencies of electromagnetic radiation or conversion of at least
part of emitted electromagnetic radiation to a more desirable
form.
[0239] In another aspect, the application provides a device or
assembly comprising transformation optics for transforming
electromagnetic radiation received by the device or assembly. The
device or assembly is operationally configured to receive a hollow
member in attachment thereto. In one embodiment, the center of the
transformation optics is substantially aligned with the
longitudinal axis of the hollow member. In another embodiment,
varying transformation optics are interchangeable with the device
or assembly as desired.
[0240] In one aspect, the application provides for photodynamic
therapy by employing a waveguide assembly for injecting
electromagnetic radiation and/or one or more fluids into a target
subject. In one exemplary embodiment, the application provides a
method including injecting photosensitizers that concentrate in
diseased cells of a target animal.
[0241] In another aspect, the application provides devices,
assemblies and systems including one or more anti-counterfeiting
technologies including, not necessarily limited to plastic
identifiers, e.g., particle taggants, optical devices and quantum
dots, hologram labeling, radio-frequency identification ("RFID"),
RFID crystagrams, integrated circuits, encryption, and combinations
thereof--as each is understood by the skilled artisan.
[0242] In another aspect, the application provides methods for
targeting blood contaminants of animals with electromagnetic
radiation of one or more frequencies for one or more durations as
desired.
DISCUSSION
[0243] The following description is not to be taken in a limiting
sense but is made merely for the purpose of describing the general
principles of the teachings of the embodiments discussed herein. To
better understand the novelty of the teachings of the embodiments,
reference is hereafter made to the accompanying drawings. It is to
be fully recognized that the different teachings of the embodiments
discussed below may be employed separately or in any suitable
combination to produce desired results.
[0244] As shown in the simplified illustration of FIG. 1, a first
simplified system is provided. In this embodiment, the system
suitably includes a first electromagnetic radiation source 100, a
first waveguide 102 (or "radiant energy conduit"), a first fluid
source 104 and a first treatment device 106. In another embodiment,
the first electromagnetic radiation source 100 may be understood to
include one or more waveguides 102. As shown, the treatment device
106 is in (1) radiant communication with the electromagnetic
radiant source 100 via the waveguide 102 and in (2) fluid
communication with the fluid source 104 via fluid conduit 107. The
radiation source 100 is in radiant communication with the waveguide
102 via outlet 101 and the waveguide 102 is in radiant
communication with the treatment device 106 via a proximal
attachment 108. In this embodiment, the treatment device 106 is
operationally configured to convey electromagnetic radiation and
fluid received via waveguide 102 and fluid conduit 107 to a target
site including but not necessarily limited to a subcutaneous target
site of a subject 10, which in FIG. 1 includes a blood vessel
15.
[0245] The system may also include an electromagnetic radiation
source 100 operationally configured to communicate with two or more
waveguides 102. As such, electromagnetic radiation may be conveyed
via two or more waveguides 102 to target sites of one or more
subjects.
[0246] In the particular embodiment of FIG. 2, the electromagnetic
radiation source 100 includes three outlets 101 in radiant
communication with corresponding waveguides 102 and treatment
devices 106 for conveying electromagnetic radiation to blood
vessels of three separate target subjects 10. It is also
contemplated that multiple outlets 101, waveguides 102 and
treatment devices 106 may be used to convey electromagnetic
radiation to multiple sites of a single target subject 10, e.g.,
locating one treatment device 106 within a blood vessel of a target
subject's 10 arm and locating another treatment device 106 within a
blood vessel of the target subject's 10 leg. When targeting fluid
housed in a container or a surface location, multiple treatment
devices 106 may target a similar container or site.
[0247] Suitably, the treatment device 106 includes at least one
port, inlet, or connection member operationally configured to
receive or otherwise communicate with the waveguide 102 and at
least one port, inlet, or connection member operationally
configured to receive or otherwise communicate with the fluid
conduit 107. It is contemplated that in one embodiment the
treatment device 106 receive only electromagnetic radiation and no
fluid, whereby the treatment device 106 is provided with only one
or more connection members operationally configured to receive
waveguides 102 in communication therewith. In still another
embodiment, the treatment device 106 may be provided with one or
more multi-purpose connection members operationally configured to
receive or otherwise communicate with either a waveguide 102 or a
fluid conduit 107.
[0248] In one embodiment, the electromagnetic radiation source 100
may be operationally configured to produce electromagnetic
radiation across the electromagnetic spectrum. In another
embodiment, the electromagnetic radiation source 100 may be
operationally configured to produce electromagnetic radiation
across a particular range of frequencies or wavelengths. In still
another embodiment, the electromagnetic radiation source 100 may be
operationally configured to produce electromagnetic radiation at a
particular frequency or wavelength. In still another embodiment,
the electromagnetic radiation source 100 may be operationally
configured to produce electromagnetic radiation across the
electromagnetic spectrum at one or more intensities and/or one or
more frequencies for a particular duration or durations. Thus, in
one embodiment the electromagnetic radiation source 100 may be
programmable or otherwise controlled manually to emanate
electromagnetic radiation there from as desired.
[0249] Turning to FIGS. 3 and 4, a simplified embodiment of a
treatment device 106 is provided including a first body 109 and a
second body 110 in communication with the first body 109. As shown,
the first body 109 has a longitudinal axis A-A and the second body
110 has a longitudinal axis B-B. Non-linear configurations of the
bodies 109 and 110 are also herein contemplated for implementation.
The outer surfaces of the first and second bodies 109, 110 are not
necessarily limited to a particular surface ornamentation, but, it
may be desirable to include an outer surface configuration for ease
of use by one or more persons handling or using the treatment
device 106. Thus, the outer surface of the treatment device 106 may
be smooth and/or textured. The outer surface of the treatment
device 106 may also include raised surface members or depressed
surface areas, e.g., parallel ridges to frictionally engage a
person's hand or fingers.
[0250] As depicted in FIG. 4, the first body 109 includes (1) a
first inlet 111 in communication with a first opening 114 therein
and (2) a first outlet 113 in communication with a second opening
115 therein--the first opening 114 being in radiant communication
with the second opening 115. The second body 110 includes a second
inlet 112 in communication with a third opening 116 therein. The
second body 110 is suitably connected to the first body 109 in a
manner effective to communicate the third opening 116 with the
second opening 115. Thus, the second opening 115 suitably lies in
communication with both the first opening 114 and the third opening
116.
[0251] More particularly, the first inlet 111 is operationally
configured to receive a waveguide 102 in attachment thereto to
provide radiant communication between the electromagnetic radiation
source 100 and the first body 109. Likewise, the second inlet 112
is operationally configured to receive a fluid conduit 107 in
attachment thereto to provide fluid communication between the fluid
source 104 and the second body 110. Thus, the first outlet 113
suitably lies (1) in radiant communication with the first inlet 111
and (2) in fluid communication with the second inlet 112 in a
manner effective to emit electromagnetic radiation and/or discharge
fluid out through the first outlet 113.
[0252] In one embodiment, the first and second inlets 111, 112 may
be operationally configured to receive a corresponding waveguide
102 and fluid conduit 107 in releasable attachment thereto. In
another embodiment, one or more of the inlets 111, 112 may be
operationally configured to receive a corresponding waveguide 102
and fluid conduit 107 in permanent attachment thereto. As desired,
the one or more of the inlets 111, 112 may be operationally
configured to receive a corresponding waveguide 102 and fluid
conduit 107 in sealed attachment thereto or in a manner effective
to diminish leakage of radiant energy and/or fluid during operation
of the treatment device 106 and system. In still another
embodiment, the treatment device 106, waveguide 102 and fluid
conduit 107 may be provided as a single assembly.
[0253] Still referring to FIG. 4, the first opening 114 and the
second opening 115 may be linearly aligned along the longitudinal
axis A-A of the first body 109. In another embodiment, the first
opening 114 and the second opening 115 may be linearly aligned
substantially parallel to the longitudinal axis A-A of the first
body 109. In still another embodiment, the first opening 114 and
the opening 115 may be disposed within the first body 109 in a
non-linear configuration effective to guide electromagnetic
radiation from the first inlet 111 out through the outlet 113.
[0254] Suitably, the first opening 114 and the second opening 115
have an inner surfaces operationally configured to guide
electromagnetic radiation there through as desired. Thus, in one
aspect, the treatment device 106 functions as a waveguide effective
to guide electromagnetic radiation received at the first inlet 111
out through the first outlet 113 as desired. In one embodiment, the
treatment device 106 may guide electromagnetic radiation there
through unobstructed. In another embodiment, the treatment device
106 may be operationally configured to act on the electromagnetic
radiation in one or more modes effective to transform the
electromagnetic radiation prior to exiting out through the first
outlet 113.
[0255] As shown in FIG. 4, the first and second openings 114, 115
may be defined by cylindrical inner surfaces. In another
embodiment, the first and second openings 114, 115 may be defined
by curved non-cylindrical inner surfaces. In another embodiment,
the first and second openings 114, 115 may be defined by
multi-sided inner surfaces. It is also contemplated that the first
and second openings 114, 115 be provided with non-corresponding
inner surfaces, e.g., the first opening 114 having four sides and
the second opening 115 having a cylindrical inner surface. In one
embodiment, the first and second openings 114, 115 may include
substantially similar inner diameters or widths. In another
embodiment, first and second openings 114, 115 may include
different inner diameters or widths. As shown in FIG. 4, the first
opening 114 includes a larger diameter than the second opening
115.
[0256] In other embodiments, the size and shape of the first inlet
111 may or may not correspond to the size and shape of the first
opening 114 and the size and shape of the first outlet 113 may or
may not correspond to the size and shape of the second opening 115.
In still another embodiment, the size and shape of the first inlet
and/or the first opening 114 may be determined according to the
size and shape of a waveguide 102 or intermediary device to be
attached to the first inlet 111. Likewise, the size and shape of
the first outlet 113 may be determined according to a particular
target site of a subject 10, a particular dosage of radiant energy
to be applied to a subject 10 and/or the size and shape of a hollow
puncture forming member to be attached to the first outlet 113.
[0257] Still referring to FIGS. 3 and 4, the treatment device 106
may be operationally configured in a manner whereby the third
opening 116 lies in fluid communication with second opening 115 at
a point along the length of the first body 109 whereby fluid
entering the second opening 115 may flow a particular distance to
the outlet 113 as desired. Suitably, the fluid may flow through the
treatment device 106 under pressure or via gravity in a manner
effective for the fluid to exit out through the first outlet 113 as
desired. In one embodiment, fluid may flow out through the first
outlet 113 in a constant flow. In another embodiment, the system
and/or treatment device 106 alone may be provided in a manner
effective to provide intermittent fluid flow out through the first
outlet 113.
[0258] It is also contemplated that a fluid in the form of a liquid
or liquid composition having a known refractive index may be
introduced into the treatment device 106 via second inlet 112. In
such embodiment, the present system may be operationally configured
to produce a particular radiant energy at the radiation source 100
and transform the radiant energy within the treatment device 106
via the liquid or liquid composition within the second opening 115
to produce a desired radiant energy emitted out through the first
outlet 113. In other words, the waveguide characteristics of the
treatment device 106 may be changed as desired according to the
refractive index of the fluid introduced into the treatment device
106. Said another way, the numerical aperture of the treatment
device 106 may be altered as desired or otherwise determined
according to type of fluid introduced into the treatment device
106. In one simplified example where the fluid source is a saline
solution administered to a target subject, a first commercially
available saline solution product may have a higher salt content
than a second commercially available saline solution product,
changing the index of refraction of the fluid of the system. In
such situation where the first saline solution product is replaced
by the second saline solution product for a particular target
subject, the output of electromagnetic radiation at the radiation
source 100 may need to be adjusted to ensure a substantially
similar emission of electromagnetic radiation out from the
treatment device 106. Likewise, the radiation source 100 may need
to be adjusted to ensure a substantially similar emission of
electromagnetic radiation out from the treatment device 106 when
the index of refraction of a known fluid is changed by the addition
of one or more one or more therapeutic agents to the fluid being
administered to a target subject. Thus, it is herein contemplated
that one or more calculations may be made to determine a particular
frequency and amplitude of radiant energy to be emitted from a
treatment device 106 or treatment assembly 200, 300 (discussed
below) based on the index of refraction of the fluid or fluid
solution used in addition to other system characteristics or
parameters. Such calculations may also take into account
degradation qualities of the waveguide 102 and/or treatment device
106 being used.
[0259] The treatment device 106 may also include one or more
optical interfaces 120 located between the first inlet 111 and the
second opening 115 for transforming electromagnetic radiation
transmitted through the treatment device 106. In one example, one
or more optical interfaces 120 may be located at the junction
between the first opening 114 and the second opening 115. In still
another embodiment, one or more optical interfaces 120 may be
located at one or more points within the second opening 115. The
one or more optical interfaces 120 are suitably operationally
configured to transform the electromagnetic radiation received from
the waveguide 102 into a particular type of electromagnetic beam
126 (see for example FIG. 5) to be emitted out from the treatment
device 106 via the first outlet 113. In still another
implementation, it is further contemplated that the system may be
operationally configured to produce a particular radiant energy at
the radiation source 100 and transform the radiant energy within
the treatment device 106 via the liquid or liquid composition
within the second opening 115 and one or more optical interfaces
120 to transform the electromagnetic radiation received from the
waveguide 102 into a particular type of electromagnetic beam 126 to
be emitted out through the first outlet 113.
[0260] As understood by a skilled artisan, electromagnetic
radiation 125 propagates through a waveguide, such as an optical
fiber, according to the phenomenon of total internal reflection
(see for example FIG. 5). By employing one or more optical
interfaces 120 the present treatment device 106 is operationally
configured to transform, e.g., decrease the spatial cross section
of the electromagnetic radiation 126 as desired. It is also
contemplated that the frequency and amplitude of the
electromagnetic radiation 125 may be changed and/or controlled via
non-linear conversions including, but not necessarily limited to
the addition of quantum dots to fluid entering the treatment device
106.
[0261] In one implementation, the one or more optical interfaces
120 of the present application may be described as optical lenses.
Suitable optical lenses include, but are not necessarily limited to
parallel radiant energy forming lenses, grin lenses, focusing
lenses, and combinations thereof. In one embodiment, the treatment
device 106 may include a parallel radiant energy forming lens 120
within the first body 109 or adjacent the first inlet 111 or first
outlet 113. For example, the lens 120 may include a collimating
lens operationally configured to transform electromagnetic
radiation into parallel electromagnetic beams as shown in the
simplified illustration of FIG. 5. In one embodiment, the numerical
aperture of a collimating lens is about equal to the numerical
aperture of the source, i.e., the waveguide coupled to the
collimator. In another embodiment, the numerical aperture of a
collimating lens is greater than the numerical aperture of the
source. In another embodiment, the numerical aperture of a
collimating lens is less than the numerical aperture of the
source.
[0262] In another embodiment, one or more optical interfaces 120
may be provided as grin lenses (as understood by persons of
ordinary skill in the art of gradient-index optics) operationally
configured to substantially match the propagation of
electromagnetic radiation received from a waveguide 102 into the
propagation defined by treatment device 106 and/or the hollow
puncture forming member 150 (see FIG. 6) attached thereto. In
another embodiment, one or more optical interfaces 120 may be
provided as focusing lenses operationally configured to focus
substantially all of the radiant energy exiting the waveguide 102
into a hollow puncture forming member 150 in radiant communication
there with. Thus, in one embodiment the distance of the proximal
end 152 of a hollow puncture forming member 150 from an optical
interface 120 may be determined according to the focal length of
the optical interface 120.
[0263] In one non-limiting embodiment, the focusing lens may
include, but is not necessarily limited to a plano-convex lens.
Depending on (1) the desired radiant energy output conveyed to a
target, and/or (2) the configuration of the waveguide 102 and/or
the treatment device 106 and/or the hollow puncture forming member
150, one or more optical interfaces 120 including, but not
necessarily limited to plano-convex lenses, biconvex lenses,
positive meniscus lenses, negative meniscus lenses, plano concave
lenses, biocancave lenses, and combinations thereof may be employed
as desired.
[0264] As shown in FIGS. 5 and 6, optical interfaces 120 may extend
across substantially the entire width or diameter of the opening
where housed in a manner effective to prevent radiant energy from
passing out around the perimeter of the optical interface 120. In
one embodiment, an optical interface 120 may be located at the
junction between a first opening 114 and the second opening 115
whereby the optical interface 120 extends across the whole inner
surface of the first opening 114 ensuring that the radiant energy
intended to exit out from the first outlet 113 first propagates
through the optical interface 120. In another embodiment as shown
in FIG. 7, including an optical interface 120 located at the
junction between a first opening 114 and the second opening 115,
the optical interface 120 may be located within the second opening
115 extending across substantially the entire inner diameter of the
second opening 115 in a manner effective to prevent radiant energy
from passing out around the perimeter of the optical interface
120.
[0265] With reference again to FIG. 6, the first outlet 113 may be
operationally configured to receive a hollow puncture forming
member 150 in permanent or releasable attachment thereto. Suitably,
the hollow puncture forming member 150 lies in both radiant
communication and fluid communication with the second opening 115
in a manner effective to (1) receive and emit electromagnetic
radiation and (2) receive and discharge fluid out through the open
tip 151 of the hollow puncture forming member 150 (see for example
FIG. 8). Thus, in one embodiment the hollow puncture forming member
150 suitably comprises an inner surface operationally configured to
act as a waveguide, e.g., a liquid light guide, for guiding
electromagnetic radiation out through the open tip 151. As such,
the treatment device 106 may be defined as having at least two
waveguides in radiant communication for delivery of electromagnetic
radiation from a waveguide 102 to a target site of a subject 10 out
beyond the open tip 151.
[0266] Referring to FIGS. 6-7, the first outlet 113 and second
opening 115 may provide a female type mating surface for receiving
a hollow puncture forming member 150 therein. Although a hollow
puncture forming member 150 may be mated to a functionally
desirable depth within the second opening 115, the proximal end 152
of the hollow puncture forming member 150 suitably remains
downstream of the junction 129 between second opening 115 and third
opening 116 during operation. To ensure such configuration, the
inner surface of the second opening 115 may include a raised
surface as desired operationally configured to act as a stop for
preventing travel distance of a hollow puncture forming member 150
beyond such stop. In another embodiment (not shown), the second
opening 115 may be provided as a threaded connection for receiving
a corresponding hollow puncture forming member 150 in threaded
connection thereto. In still another embodiment, the hollow
puncture forming member 150 may include a hub 155 operationally
configured to attach to or slip onto the first body 109 whereby the
opening of the hollow puncture forming member 150 is axially
aligned with the longitudinal axis A-A of the first body 109 (see
for example FIGS. 9 and 10).
[0267] Without limiting the invention to a particular embodiment,
one exemplary hollow puncture forming member 150 may include a
cannula. In another embodiment, the hollow puncture forming member
150 may include an intravenous cannula. Cannula may have a blunt
end, e.g., blunt-tip microcannula, beveled blunt end cannula, or
deflected tip point as desired. Suitable cannula may be constructed
from one or more materials, including non-static materials,
including but not necessarily limited to metals, plastics,
composite materials, crystalline materials, and combinations
thereof. In one exemplary embodiment, a cannula may be constructed
from stainless steel. In another exemplary embodiment, a cannula
may be constructed from hyperchrome stainless steel tubing. Cannula
may also include lancent points as desired.
[0268] In another embodiment, the hollow puncture forming member
150 may include a hollow needle type device. Suitable needles may
include, but are not necessarily limited to reusable or disposable
hypodermic needles, emulsifying needles, lancet point needles,
non-coring needles, and pipetting needles constructed from one or
more materials, for example non-static materials, including but not
necessarily limited to metals, plastics, composite materials,
crystalline materials, and combinations thereof. Suitable
hypodermic needle materials of construction include, but are not
necessarily limited to aluminum, tantalum, stainless steel,
niobium, nickel iron alloys, nickel alloys, molybdenum, silicon,
polymeric materials, composite materials, and combinations thereof.
In another embodiment, hypodermic needles may be constructed from
polytetrafluoroethylene ("PTFE"). Hypodermic needles may also
include one or more tipping technologies to effect hypodermic
injections or to otherwise enhance penetration of a surface of a
target site. Suitable tipping technologies include, but are not
necessarily limited to tips coated with PTFE. Because the treatment
device 106 may be built to scale, the needle to be employed is not
necessarily limited to any particular gauge or range of gauges.
[0269] In still another embodiment, the hollow puncture forming
member 150 may include a catheter or flexible catheter tube
operationally configured to be inserted into a target body cavity,
duct, or vessel. Suitable catheters may include, but are not
necessarily limited to angioplasty catheters, internal drug
delivery catheters, laser ablation catheters, ultrasonic ablation
catheters, thermal or mechanical disruptive catheters, stent
delivery catheters, catheters for monitoring drug or other chemical
concentrations/indications in vivo, and catheters for monitoring
body functions (e.g., cardiac output). One exemplary catheter may
include a tapered PTFE catheter.
[0270] In still another embodiment, the hollow puncture forming
member 150 may include a liquid light guide. In one embodiment, the
treatment device 106 may be operationally configured to receive a
light guide adapter in releasable attachment thereto for
communicating the treatment device 106 with the liquid light guide.
In another embodiment, the distal end of the treatment device 106
or first outlet 113 may be operationally configured to receive a
liquid light guide in direct attachment thereto.
[0271] In one aspect, the hollow puncture forming member 150 may
provide for atraumatic insertion for providing radiant energy and
one or more therapeutic agents as described above. Depending on the
intended use, a particular hollow puncture forming member 150 may
also be provided as a medical grade device, e.g., sterile,
disposable, reusable. As stated, the treatment device 106 and
hollow puncture forming member 150 may be built to scale for a
particular operation. Said another way, treatment using the present
device, assembly, system and method is scalable whereby larger
inner width or inner diameter hollow puncture forming members 150
may be operationally configured to convey more radiant energy there
through than smaller hollow puncture forming members 150. Although
the treatment device 106 and hollow puncture forming member 150 may
be built to scale, for the purposes of subcutaneous applications in
animals, suitable hollow puncture forming members 150 may include
hypodermic needles according to, but not necessarily limited to the
size characteristics of Table 1 below.
TABLE-US-00001 TABLE 1 Nominal Outer Diameter Nominal Inner
Diameter Nominal Wall Thickness tol. tol. tol. Needle inches inches
inches Gauge inches mm (mm) inches mm (mm) inches mm (mm) 7 0.180
4.572 .+-.0.001 0.150 3.810 .+-.0.003 0.015 0.381 .+-.0.001
(.+-.0.025) (.+-.0.076) (.+-.0.025) 8 0.165 4.191 '' 0.135 3.429 ''
'' '' '' 9 0.148 3.759 '' 0.118 2.997 '' '' '' '' 10 0.134 3.404 ''
0.106 2.692 '' 0.014 0.356 '' 11 0.120 3.048 '' 0.094 2.388 ''
0.013 0.330 '' 12 0.109 2.769 '' 0.085 2.159 '' 0.012 0.305 '' 13
0.095 2.413 '' 0.071 1.803 '' '' '' '' 14 0.083 2.108 '' 0.063
1.600 '' 0.01 0.254 '' 15 0.072 1.829 .+-.0.0005 0.054 1.372
.+-.0.0015 0.009 0.229 .+-.0.0005 (.+-.0.013) (.+-.0.038)
(.+-.0.013) 16 0.065 1.651 '' 0.047 1.194 '' '' '' '' 17 0.058
1.473 '' 0.042 1.067 '' 0.008 0.203 '' 18 0.050 1.270 '' 0.033
0.838 '' 0.0085 0.216 '' 19 0.042 1.067 '' 0.027 0.686 '' 0.0075
0.191 '' 20 0.03575 0.9081 .+-.0.00025 0.02375 0.603 .+-.0.00075
0.006 0.1524 .+-.0.00025 (.+-.0.0064) (.+-.0.019) (.+-.0.0064) 21
0.03225 0.8192 '' 0.02025 0.514 '' '' '' '' 22 0.02825 0.7176 ''
0.01625 0.413 '' '' '' '' 22s '' '' '' 0.006 0.152 '' 0.0111 0.2826
'' 23 0.02525 0.6114 '' 0.01325 0.337 '' 0.006 0.1524 '' 24 0.02225
0.5652 '' 0.01225 0.311 '' 0.005 0.1270 '' 25 0.02025 0.5144 ''
0.01025 0.260 '' '' '' '' 26 0.01825 0.4636 '' '' '' '' 0.004
0.1016 '' 26s 0.01865 0.4737 '' 0.005 0.127 '' 0.0068 0.1734 '' 27
0.01625 0.4128 '' 0.00825 0.210 '' 0.004 0.1016 '' 28 0.01425
0.3620 '' 0.00725 0.184 '' 0.0035 0.0889 '' 29 0.01325 0.3366 '' ''
'' '' 0.003 0.0762 '' 30 0.01225 0.3112 '' 0.00625 0.159 '' '' ''
'' 31 0.01025 0.2604 '' 0.00525 0.133 '' 0.0025 0.0635 '' 32
0.00925 0.2350 '' 0.00425 0.108 '' '' '' '' 33 0.00825 0.2096 '' ''
'' '' 0.002 0.0508 '' 34 0.00725 0.1842 '' 0.00325 0.0826 '' '' ''
''
[0272] It is also contemplated that a suitable hollow puncture
forming member 150 may include a hypodermic needle according to,
but not necessarily limited to the size characteristics of Table 2
below.
TABLE-US-00002 TABLE 2 Needle Nominal O.D. Nominal I.D. Gauge mm
inches tol. (in.) mm inches tol. (in.) 10 3.404 0.1340 .+-.0.0010
2.692 0.1060 .+-.0.0020 11 3.048 0.1200 '' 2.388 0.0940 '' 12 2.769
0.1090 '' 2.159 0.0850 '' 13 2.413 0.0950 '' 1.803 0.0710 '' 14
2.108 0.0830 '' 1.600 0.0630 '' 15 1.829 0.0720 .+-.0.0005 1.372
0.0540 .+-.0.0015 16 1.651 0.0650 '' 1.194 0.0470 '' 17 1.473
0.0580 '' 1.067 0.0420 '' 18 1.270 0.0500 '' 0.838 0.0330 '' 19
1.067 0.0420 '' 0.686 0.0270 '' 20 0.902 0.0355 .+-.0.0005 0.584
0.0230 .+-.0.0015 -0.0000 -0.0000 21 0.813 0.0320 '' 0.495 0.0195
'' 22 0.711 0.0280 '' 0.394 0.0155 '' 22s 0.711 0.0280 '' 0.140
0.0055 '' 23 0.635 0.0250 '' 0.318 0.0125 '' 24 0.559 0.0220 ''
0.292 0.0115 '' 25 0.508 0.0200 '' 0.241 0.0095 '' 25s 0.508 0.0200
'' 0.140 0.0055 '' 26 0.457 0.0180 '' 0.241 0.0095 '' 26s 0.467
0.0184 '' 0.114 0.0045 '' 27 0.406 0.0160 '' 0.191 0.0075 '' 28
0.356 0.0140 '' 0.165 0.0065 '' 29 0.330 0.0130 '' 0.165 0.0065 ''
30 0.305 0.0120 '' 0.140 0.0055 '' 31 0.254 0.0100 '' 0.114 0.0045
'' 32 0.229 0.0090 '' 0.089 0.0035 '' 33 0.203 0.0080 '' 0.089
0.0035 ''
In animals, the length of a particular hypodermic needle employed
suitably includes a length operationally configured to convey
electromagnetic radiation to one or more particular subcutaneous
target sites. In other words, the length of a particular hypodermic
needle may be determined according to the size of the target
subject. Without limiting the length of hypodermic needles to a
particular range, for the purposes of subcutaneous applications in
animals, suitable lengths may include from about 0.01 mm to about
5.0 meters. In human applications, a suitable hypodermic needle may
range in length from about 1.0 mm to about 50.0 cm. In another
embodiment, it is contemplated that nanoneedles (as understood by
the skilled artisan) may be employed. It is also contemplated that
varying needle point styles may be employed as desired.
[0273] As shown in FIG. 10, the hollow puncture forming member 150
may be provided with wings 130 (also commonly referred to as a
"butterfly" by persons of ordinary skill in the art of healthcare
services) to allow for easy fixation of the treatment device 106 to
a target subject 10 to help prevent pistoning and/or rolling of the
treatment device 106 during operation. In other embodiments, it is
contemplated that the first body 109 itself may include a puncture
forming outer surface configuration at a distal end 131 (see FIG.
11). In one particular embodiment, the treatment device 106 may be
provided as a tapered PTFE device providing for atraumatic
insertion of the first body 109.
[0274] With attention to FIG. 12, the distal portion of a hollow
member or a hollow puncture forming member 150 or first body 109
may include a closed tip with one or more apertures 132 located at
or near the tip of the hollow puncture forming member 150
operationally configured for conveyance of electromagnetic
radiation there through. In another embodiment, the distal portion
of the hollow member or hollow puncture forming member 150 or first
body 109 may include a closed tip comprising one or more
transparent materials, one or more partially transparent materials,
one or more translucent materials, one or more partially
translucent materials, and combinations thereof forming one or more
windows 133 near the closed tip operationally configured for
conveyance of electromagnetic radiation there through (see FIG.
13). In another embodiment, a hollow puncture forming member 150 or
first body 109 may include a combination of the elements of FIGS.
12 and 13. In still another embodiment, a hollow puncture forming
member 150 or first body 109 may include an open tip 151 or first
outlet 113 in addition to the elements of FIGS. 12 and 13.
[0275] Turning to FIGS. 14A-14C, another simplified embodiment of a
treatment device 106 is provided. Like the embodiment described
above, the treatment device 106 of this embodiment suitably
includes a hollow first body 109 having a longitudinal axis C-C and
a second body 110 in communication with the first body 109 and
having a longitudinal axis D-D, the first body 109 being
operationally configured to receive a waveguide 102 at a first end
and a hollow puncture forming member 150 at a second end, the
second body 110 being operationally configured to receive a fluid
conduit 107 in attachment thereto. Other non-linear configurations
of the bodies 109 and 110 are also contemplated for implementation
with this particular embodiment of the treatment device 106. In one
implementation, the second body 110 may be flexible or
bendable.
[0276] With attention to FIGS. 14A-B, the treatment device 106 may
further include a conduit 134 in fluid communication with the
second body 110 at a first end and operationally configured to
receive a fluid conduit 107 in fluid communication thereto. The
conduit 134 may be provided as a substantially straight member in
axial alignment according to longitudinal axis D-D. In another
embodiment, the conduit 134 may be provided as a non-linear member
as shown. A conduit 134 may be constructed from one or more rigid
materials and/or one or more flexible materials as desired. For
example, the conduit 134 may be constructed from one or more
metals, polymeric materials, rubbers, glass, plexiglass, filled
composite materials, and combinations thereof. Likewise, the
conduit 134 may include a length as desired for a particular use.
Where the treatment device 106 is to be used to convey radiant
energy to a subcutaneous site of an animal, the conduit 134
suitably includes a shape and/or a length providing for adequate
manipulation and/or placement of the treatment device 106 and fluid
conduit 107 for ease of operation. For use with persons, the
conduit 134 may be provided as a flexible tube constructed from one
or more polymeric materials and have a length from about 1.27 cm to
about 30.48 (about 0.5 inches to about 12.0 inches). With reference
to FIG. 14A, one suitable conduit 134 for use with a person 10 has
a length of about 11.43 cm (about 4.5 inches).
[0277] In one suitable embodiment, the conduit 134 engages the
second body via a sealable connection to minimize fluid loss out
from the point of attachment between the conduit 134 and the second
body 110. In another suitable embodiment, an interconnector may be
used to join the conduit 134 to the second body 110 as a snap fit
or threaded type male/female fitting. In another suitable
embodiment, the distal end of the conduit 134 may include a mating
surface or other connector operationally configured to mate or
otherwise engage the second inlet 112 or second body 110. In
addition, the first inlet 111 is operationally configured to
receive a waveguide 102 in radiant communication there with in a
manner effective to prevent or otherwise minimize leakage, emission
or escape of electromagnetic radiation from within the first body
109, e.g., at a junction between the first body 109 and the
waveguide 102.
[0278] The treatment device 106 of FIGS. 14A-14C suitably includes
one or more optical interfaces 120 housed within a compartment 135
near the first inlet 111 in a manner effective to transform radiant
energy received therein to produce a treatment dose of radiant
energy emitted out through the tip 151 of the hollow puncture
forming member 150. In one particular embodiment, the treatment
device 106 is operationally configured emit radiant energy and
fluid received through the conduit 134 out through the tip 151.
[0279] As shown in the exploded view of FIG. 14C, the treatment
device 106 may be provided as an assembly including a first body
109 permanently or releasably attachable to a corresponding conduit
134, a hollow intermediary winged member 136 permanently or
releasably attachable to the first body 109 to allow for easy
fixation of the treatment device 106 to a target subject 10 to help
prevent pistoning and/or rolling of the treatment device 106 during
operation, the winged member 136 being axially aligned with the
longitudinal axis C-C, and a hollow puncture forming member 150
permanently or releasably attachable to the winged member 136, the
hollow puncture forming member 150 being axially aligned with the
longitudinal axis C-C.
[0280] The hollow intermediary winged member 136 may be
substantially planar or include a surface ornamentation effective
to abut an outer surface as desired. For example, the hollow
intermediary winged member 136 may include a curved surface
operationally configured to abut the curvature of the surface of a
person's 10 arm. Likewise, the hollow intermediary winged member
136 (or other portion of the treatment device 106) may include an
adhesive type surface for adhering the treatment device to a target
surface. In addition to single use disposal of one or more of the
above parts of the treatment device 106, each of the first body
109, the conduit 134, the hollow intermediary winged member 136,
and the hollow puncture forming member 150 may be operationally
configured for reuse in any combination.
[0281] With reference now to FIGS. 15A-15C, another simplified
embodiment of a treatment device 106 is provided. The treatment
device 106 of this embodiment includes a first body 109 having a
first inlet 111 and first outlet 113 and a second body 110 having a
second inlet 112, the second body 110 being in fluid communication
with the first body 109. With attention to FIG. 15B, first body 109
may be described as having a multi-sectional or multi-compartment
configuration (see Sections 1, 2 and 3). Even though the outer
surface configuration of the first body 109 may vary, in the
embodiment of FIGS. 15A-15C the first body 109 includes a
cylindrical shape of one or more outer diameters. In particular,
Section 1 has the smallest outer diameter and Section 3 has the
greatest outer diameter. The particular configuration of FIGS.
15A-15C is operationally configured for use with disposable hollow
puncture forming members 150. Suitably, the configuration of the
treatment device 106 assists in minimizing material costs and/or
production costs while also being effective for different types of
treatment operations.
[0282] With attention to FIG. 15C, Section 1 of the first body 109
is operationally configured to receive a waveguide 102 in radiant
communication thereto. Suitably, Section 1 includes an opening 160
defined by an inner surface 161 operationally configured to mate
with a fiber optic connector 140. As shown in the simplified
embodiment of FIG. 15C, the inner surface 161 of the opening 160
includes a stepped configuration effective to receive a slotted
bayonet type fiber optic connector 140 such as a ST Connector in
releasable attachment thereto.
[0283] Section 2 of the first body 109 suitably includes an opening
162 defined by an inner surface 163 and one or more optical
interfaces 120 disposed across the opening 162 as desired. In
another embodiment it is contemplated that no optical interfaces
120 are employed. As shown, the opening 162 is in radiant
communication with the opening 160 of Section 1 and in fluid
communication with the second body 110, the opening 162 having a
first volume for receiving radiant energy and/or fluid therein
including one or more fluids in an amount up to the volume of the
opening 162 as received via the third opening 116. At a minimum,
the opening 162 of Section 2 includes an inner surface
configuration and/or volume operationally configured to direct
radiant energy and a desired amount of fluid out from the opening
162 into the opening 164 of Section 3, which is in radiant and
fluid communication with opening 162. Section 3 may also include an
inner surface 165 configuration effective to assist in directing
radiant energy and/or fluid from the opening 162 out through the
first outlet 113. In this particular embodiment, the opening 164
includes a funnel type configuration 166 at the junction with the
opening 162 operationally configured to optimize the amount of
radiant energy entering the opening 164. Likewise, the first outlet
113 of the opening 164 is operationally configured to receive a
hollow puncture forming member 150 in attachment thereto. Thus, in
one exemplary mode of operation, radiant energy and/or fluid
suitably exits the treatment device 106 via the first outlet 113 or
a hollow puncture forming member 150 attached thereto. Suitably,
the fluid and radiant energy are conveyed in a manner effective for
the hollow puncture forming member 150 attached thereto to act
optically similar to a liquid light guide as understood by persons
of ordinary skill in the art.
[0284] As shown in FIG. 15C, the opening 164 may include a
cylindrical shape, but the inner surface 165 of the opening 164 may
include a different surface configuration (1) for receiving a
particular shaped hollow puncture forming member 150 therein and/or
(2) for acting on the radiant energy and/or fluid conveyed there
through as desired. Section 3 may also include a threaded surface
167 as desired for receiving a hollow member, e.g., a hollow
puncture forming member 150 in releasable attachment thereto. In
addition, the second body 110 may be disposed about 45.0 degrees
relative to the longitudinal axis of the treatment device 106 as
shown or, in another embodiment, the second body 110 may be
disposed substantially perpendicular to the longitudinal axis of
the treatment device 106.
[0285] Referring now to FIG. 16, Section 2 of this embodiment
suitably includes one or more optical interfaces 120 disposed
across the inner surface 163 of the opening 162 in a manner
effective to transform the electromagnetic radiation received from
the waveguide 102 into one or more particular types of
electromagnetic beams to be emitted out through first outlet 113.
As shown, the inner surface 161 suitably receives the fiber optic
connector 140 in releasable attachment whereby the distal end of
the ferrule 141 of the connector extends to a point functionally
near or in abutment with an optical interface 120. In operation,
fluid and radiant energy are combined in the opening 162 in a
manner effective for the hollow puncture forming member 150 to
operate as a waveguide, e.g., a liquid light guide.
[0286] In this embodiment, the one or more optical interfaces 120
are operationally configured to transform the electromagnetic
radiation 125 received from a waveguide 102 in a manner effective
to emit beam(s) 126 out through the first outlet 113 and/or hollow
puncture forming member 150 attached thereto as desired. As shown
in FIG. 17, an optical interface 120 may be provided as a
collimator type lens operationally configured to transform
electromagnetic radiation into substantially parallel beams 126 as
shown. In another embodiment, an optical interface 120 may be
provided as a converging or focusing type lens operationally
configured to transform electromagnetic radiation as shown in FIG.
18. In still another embodiment, an optical interface 120 may be
provided as a diverging type lens (see FIG. 19) where the treatment
device 106 includes an opening 164 larger than the opening 162
housing the optical interface 120.
[0287] Turning now to FIGS. 20 and 21, two other embodiments of the
treatment device 106 are provided. As FIG. 20 illustrates, the
second body 110 may extend from the first body 109 according to
angle A-1. As shown in FIG. 21, the second body 110 may extend from
the first body 109 in a substantially perpendicular orientation
relative to the longitudinal axis A-A of the treatment device 106
suitable for supplying one or more fluids to the first body 109.
Surface configurations of the first and second bodies 109, 110 may
vary according to one or more particular applications as
desired.
[0288] The embodiments of FIGS. 20 and 21 are particular assemblies
operationally configured to seal or otherwise separate the
waveguide 102 from the hollow puncture forming member 150 attached
thereto. As shown in FIGS. 22 and 23, the treatment device 106 may
be provided as an assembly 200 of one or more reusable component
parts and/or one or more disposable component parts. Although the
various component parts may be assembled as desired, in one mode of
operation it is contemplated to manufacture the treatment device
(or as may be referred to here as a "treatment assembly" 200) in a
manner effective to minimize manufacturing costs and/or maximize
sales of various replacement component parts as desired.
[0289] In one simplified embodiment, the treatment assembly 200 may
include (1) a waveguide member 210, (2) a main body 220 and (3) a
hollow member assembly or a hollow puncture forming member assembly
230. In one implementation, the waveguide member 210, main body 220
and hollow puncture forming member assembly 230 may be provided
assembled and following use the entire assembly 200 may be disposed
of or reused. In another implementation, one or more component
parts may be replaced prior to reuse of the assembly 200 as
desired.
[0290] In still another implementation, the waveguide member 210,
main body 220 and hollow puncture forming member assembly 230 may
be provided unassembled whereby particular sized and/or shaped
component parts may be fitted together for a particular purpose.
For example, a hollow puncture forming member 150 of a particular
length and/or gauge may be required as compared to other
implementations of the assembly 200. In another embodiment, a
particular volume of fluid or fluid solution may be required, which
may require a main body 220 having a particular size and shape. In
still another embodiment, a waveguide member 210 of a particular
length (or a series of waveguides joined together) and/or inner
diameter or width may be necessary for a particular treatment or
use.
[0291] In one embodiment, the main body 220 includes (1) a
waveguide receiving inlet 111 operationally configured to receive a
waveguide member 210 in a manner effective to provide radiant
communication between the main body 220 and the waveguide member
210 and (2) an outlet 113 operationally configured to receive the
hollow puncture forming member assembly 230 in a manner effective
to provide radiant and fluid communication between the main body
220 and the hollow puncture forming member assembly 230. As shown
in FIGS. 22 and 23, the main body 220 may include a female type
waveguide receiving inlet 111 defined by an inner surface 221, a
fluid inlet 223, and a cavity 222 in radiant communication with the
waveguide receiving inlet and in fluid communication with the fluid
inlet 223. As shown, the main body 220 may further include one or
more optical interfaces 120 defining the border between the
waveguide receiving inlet and the cavity 222. In one particularly
advantageous embodiment, the optical interface 120 may be disposed
along the cavity 222 in a manner effective to fluidly seal the
cavity 222 from the waveguide receiving inlet 111. Where the
assembly 200 is used on an animal, the waveguide member 210 is
suitably isolated from exposure to one or more bodily fluids of an
animal to be targeted with the assembly 200. In one embodiment, the
optical interface 120 may include a lens according to the
description of lenses above. In another embodiment, the optical
interface 120 may include a window type member constructed from one
or more transparent materials, one or more partially transparent
materials, one or more translucent materials, one or more partially
translucent materials, and combinations thereof for attenuation of
electromagnetic radiation as desired.
[0292] Suitably, the cavity 222 is operationally configured to
receive a portion of the hollow puncture forming member 150 therein
up to a point of abutment of the proximal end 152 with the optical
interface 120 that forms a barrier of the cavity 222. As shown, the
proximal end 152 of the hollow puncture forming member 150 may lie
near the optical interface 120 in a manner effective to maximize a
desired amount of radiant energy and/or fluid entering the hollow
puncture forming member 150. In one embodiment, the hollow puncture
forming member assembly 230 may engage the distal end of the main
body 220 in a manner effective to prevent or other minimize
movement of the hollow puncture forming member assembly 230 during
assembly 200 operation. In another embodiment, attachment of the
hollow puncture forming member assembly 230 to the main body 220
may be accomplished solely by mating the hollow puncture forming
member 150 with the first outlet 113 in a manner effective to
prevent or other minimize movement of the hollow puncture forming
member 150 during assembly 200 operation.
[0293] In another embodiment, the main body 220 and hollow puncture
forming member assembly 230 may be provided as a single unit or one
piece item for reuse or for one time use. In such embodiment, the
orientation of the hollow puncture forming member 150 within the
cavity 222 may be preset or the hollow puncture forming member
assembly 230 may include a slidable or otherwise adjustable hollow
puncture forming member 150 for determining the distance between
the optical interface 120 and the proximal end 152 of the hollow
puncture forming member 150. It is further contemplated that a
slidable or otherwise adjustable hollow member or hollow puncture
forming member 150 may be replaced and disposed of as desired while
reusing the remaining assembly 200 component parts.
[0294] Still referring to FIGS. 22 and 23 a suitable waveguide
member 210 includes a nose 211 operationally configured to mate
with the female type waveguide receiving inlet 111 of the main body
220. In one embodiment, the nose 211 may be operationally
configured to engage the inner surface 221 in fixed abutment
thereto during operation of the assembly 200. In other embodiments,
the nose 211 may engage the inner surface 221 via one or more
methods including, but not necessarily limited to a snap-fit
connection, a threaded connection, a push and turn connection, a
screw on configuration, and a press fit connection. In another
embodiment, screws, bolts, rivets and the like may be used to
attach the nose 211 to the main body 220. Thus, it is further
contemplated that one or more seals or gasket type members may be
used between the nose 211 and the main body 220 as desired. As
shown in the embodiments of FIGS. 22 and 23, the nose 211 is mated
with the female type waveguide receiving inlet 111 of the main body
220 via a slotted connection.
[0295] Without limiting the invention to a particular embodiment,
the orientation of the nose 211 within the waveguide receiving
inlet may be determined according to one or more assembly 200
design characteristics, fluid characteristics, attenuation
characteristics of the optical interface 120, the angular
distribution of light exiting the waveguide member 210, the desired
emission of radiant energy out from the assembly 200, and
combinations thereof. As shown, the outer surface of the nose 211
may lie in substantial abutment with the inner surface 221 whereby
the outlet of the core 213 of the waveguide member 210 lies near
the optical interface 120 minimizing the distance of propagation of
electromagnetic radiation between the waveguide member 210 and the
optical interface 120. As shown, the nose 211 suitably engages the
main body 220 in a manner effective to minimize loss of radiant
energy out through the female type waveguide receiving inlet 111 of
the main body 220. In another embodiment, the nose 211 may engage
the main body 220 in a manner effective to direct radiant energy
toward the optical interface 120 at a distance up to about the
outer edge of the inlet waveguide receiving 111.
[0296] As shown in FIGS. 22 and 23, one suitable waveguide member
210 may include an outer skirt 212 for ease of manual operation.
The inner surface 215 of the skirt 212 may be operationally
configured to engage the outer surface 224 of the main body 220 in
a fixed position during operation of the assembly 200. Thus, in one
embodiment the wave guide member 210 may be attached to the main
body 220 via the skirt 212 rather than via engagement of the nose
211 and female type waveguide receiving inlet of the main body 220
as discussed above. Without limiting the mode of engagement, the
skirt 212 and outer surface 224 of the main body 220 may be
attached via cooperating threads, a lug-slot connection, a push and
turn connection, a snap-fit connection, via screws, bolts, rivets
and the like, or otherwise latching the skirt 212 to the main body
220 as desired. As shown in the embodiments of FIGS. 22 and 23, a
suitable skirt 212 may include a shoulder 214 operationally
configured to abut the perimeter of the inlet 111 providing a
desired depth of the nose 211 within the female type waveguide
receiving inlet 111 of the main body 220.
[0297] Still referring to FIGS. 22 and 23, in one suitable
embodiment at least part of the central axis of the waveguide
member 210 is substantially aligned with the central axis of the
hollow puncture forming member 150. In operation, radiant energy is
emitted from the core 213 of the waveguide member 210 through the
optical interface 120 into the proximal end 152 of the hollow
puncture forming member 150, whereby the hollow puncture forming
member 150 acts in a manner similar to a liquid light guide.
[0298] Turning now to FIG. 24, another treatment assembly 300 is
provided. Without limiting the assembly 300 to any particular
number of assembled component parts one suitable assembly 300 may
include (1) a waveguide member 310, (2) a main body 320 and (3) a
hollow member assembly or hollow puncture forming member assembly
330. In one implementation, the waveguide member 310, main body 320
and hollow puncture forming member assembly 330 may be provided
assembled and following use the entire assembly 300 may be disposed
of or reused. In another implementation, one or more component
parts of the assembly 300 may be replaced prior to reuse of the
assembly 300. In still another implementation, the waveguide member
310, main body 320 and hollow puncture forming member assembly 330
may be provided unassembled whereby particular sized and/or shaped
component parts may be fitted together for a particular treatment
or use. For example, hollow members or hollow puncture forming
member 150 of a particular length and/or gauge may be required for
a particular use as compared to other implementations of the
assembly 300. In another embodiment, a particular volume of fluid
or fluid solution may be required, which may require a main body
320 having a particular size and shape cavity 322 for receiving
fluid therein. In still another embodiment, a waveguide member 310
of a particular length (or a series of waveguides joined together)
and/or inner diameter or width may be necessary for a particular
treatment or use.
[0299] As shown, the waveguide member 310 may include one or more
waveguides 102 in series and one or more optical interfaces 120
mounted at the distal end of the waveguide 102. In one embodiment,
one or more optical interfaces 120 may be permanently connected to
the waveguide 102. In another embodiment, one or more optical
interfaces 120 may be releasably attached to the waveguide 102
providing for interchangeability of optical interfaces 120 and
varying the possible optical characteristics of the waveguide
member 310 and/or assembly 300. In one embodiment, an optical
interface 120 may be connected to a waveguide 102 via one or more
intermediary members operationally configured to convey
electromagnetic radiation from the waveguide 102 toward the optical
interface 120. Without limiting the invention, suitable
intermediary members may include spacer type members with apertures
there through, e.g., a ring type spacer connected on one side by
the waveguide 102 and connected to the optical interface 120 on its
opposing side. As seen in the simplified embodiment of FIGS. 24 and
25, the waveguide member 310 includes an optical mount 313
operationally configured to surround or otherwise enclose at least
part of the waveguide 102 and at least part of the optical
interface 120 in a manner effective to maintain the optical
interface 120 in a fixed position relative to the waveguide 102. In
addition, the optical mount 313 may act as the nose of the
waveguide member 310 for purposes of engaging the main body 320,
thus, the outer surface of the optical mount 313 may include a
surface configuration for attachment to the main body 320 as
desired. For example, the optical mount 313 may engage the main
body 320 in a manner similar as the nose 211 discussed above in
relation to FIGS. 22 and 23. Likewise, the waveguide member 310 may
include a skirt 312 and shoulder 314 similar as discussed
above.
[0300] In one embodiment, the main body 320 may include (1) an
inlet 111 operationally configured to receive a waveguide member
310 in a manner effective for radiant communication between the
main body 320 and the waveguide member 310 and (2) an outlet 113
operationally configured to receive the hollow puncture forming
member assembly 330 in a manner effective for radiant and fluid
communication between the main body 320 and the hollow puncture
forming member assembly 330. As shown, the main body 320 may
include a female type waveguide receiving inlet 111 defined by an
inner surface 321, a fluid inlet 323 and a cavity 322 in radiant
communication with the female type waveguide receiving inlet 111
and in fluid communication with the fluid inlet 323. In addition,
the main body 320 may include a secondary optical interface 350
defining the border between the waveguide receiving inlet 111 and
the cavity 322. In one particularly advantageous embodiment, the
secondary optical interface 350 may be disposed along the cavity
322 in a manner effective to fluidly seal the cavity 322 from the
waveguide receiving inlet 111 and, thus, physically seal the cavity
322 from the waveguide member 310 of the assembly 300--providing
separation between the waveguide member 310 and the hollow puncture
forming member 150. In one embodiment, the secondary optical
interface 350 may include a lens according to the description of
lenses above. In another embodiment, the secondary optical
interface 350 may include a substantially planar window type member
constructed from one or more transparent materials, one or more
partially transparent materials, one or more translucent materials,
one or more partially translucent materials, and combinations
thereof, for attenuation of electromagnetic radiation as desired.
In one suitable embodiment, the secondary optical interface 350 may
include a transparent plastic material. In another suitable
embodiment, the secondary optical interface 350 may include a
transparent glass material. In another suitable embodiment, the
secondary optical interface 350 may include a transparent
crystalline material. Without limiting the invention, a suitable a
secondary optical interface 350 may include a material (1)
substantially impermeable to fluids or fluid solutions entering the
cavity 322 during assembly 300 operation and (2) operationally
configured to affect or not affect the propagation of radiant
energy guided through the assembly 300 as desired. Where the
assembly 300 is used on an animal, the waveguide member 310 is
suitably isolated from exposure to one or more bodily fluids of the
animal to be targeted with the assembly 300.
[0301] Still referring to FIG. 24, the cavity 322 is operationally
configured to receive a portion of the hollow puncture forming
member 150 therein up to a point of abutment of the proximal end
152 of the hollow puncture forming member 150 with the secondary
optical interface 350. As shown, the proximal end 152 of the hollow
puncture forming member 150 may lie near the secondary optical
interface 350 in a manner effective to maximize a desired amount of
radiant energy and/or fluid entering the hollow puncture forming
member 150. In one embodiment, the hollow puncture forming member
assembly 330 may engage the distal end of the main body 320. For
example, the outer surface of the main body 320 may be
operationally configured to receive the hollow puncture forming
member assembly 330 in releasable attachment thereto. In another
embodiment, attachment of the hollow puncture forming member
assembly 330 to the main body 320 may be accomplished solely by
mating the hollow puncture forming member 150 with the first outlet
113 in a manner effective to prevent or other minimize movement of
the hollow puncture forming member 150 during assembly 300
operation. In still another embodiment, the main body 320 and
hollow puncture forming member assembly 330 may be provided as a
single unit or one piece item for reuse or for one time use. In
such embodiment, the orientation of the hollow puncture forming
member 150 within the cavity 322 may be preset or the hollow
puncture forming member assembly 330 may include a slidable or
otherwise adjustable hollow puncture forming member 150 for
determining the distance between the secondary optical interface
350 and the proximal end 152 of the hollow puncture forming member
150. It is further contemplated that a slidable or otherwise
adjustable hollow puncture forming member 150 may be replaced and
disposed of as desired while reusing the remaining assembly 300
component parts.
[0302] Turning to FIG. 26, in operation electromagnetic radiation
125 may be conveyed through the core 213 of the waveguide member
310 and an optical interface 120, which is operationally configured
to transform the electromagnetic energy 125 in a manner effective
to convey transformed electromagnetic radiation 126 into the
proximal end 152 of the hollow puncture forming member 150, whereby
the hollow puncture forming member 150 is operationally configured
to receive electromagnetic radiation 126 and fluid or a fluid
solution received from fluid inlet 323 (according to exemplary
Arrow F) in a manner effective for the hollow puncture forming
member 150 to act in a similar manner as a liquid light guide for
delivering radiant energy to one or more target sites, including a
therapeutic amount of radiant energy and/or fluid or a fluid
solution. As shown in FIG. 26, at least part of the central axis of
the waveguide member 310 is substantially aligned with the central
axis of the hollow puncture forming member 150.
[0303] Turning to FIGS. 27-32, another treatment assembly 400 is
provided. As shown in the simplified exploded view FIG. 27, the
treatment assembly 400 suitably includes three main components,
namely (1) a cable member 401, (2) an interconnect member 402 and
(3) a hollow dispensing member 403. The cable member 401 is in
radiant communication with electromagnetic radiation source 100 and
the interconnect member 402. The interconnect member 402 is further
in radiant communication with the hollow dispensing member 403 and
in fluid communication with a fluid source 104. The hollow
dispensing member 403 is operationally configured to provide an
exit point of electromagnetic radiation and/or one or more fluids
or fluid solutions out from the treatment assembly 400.
[0304] With attention to FIG. 28, the cable member 401 is
operationally configured to receive a waveguide 102 in radiant
communication therewith. In this particular embodiment, the cable
member 401 includes an overmold member 404 with a first opening or
port 405 operationally configured to mate with a terminal end of a
waveguide 102, e.g., a termination ferrule 407, and a second
opening or port 406 operationally configured to mate with the
interconnect member 402. Without limiting the invention, a suitable
cable member 401 may further include the following component parts:
(1) an electrical connector 409, (2) a printed circuit board
("PCB") 410, (3) one or more light emitting diodes ("LED") 411 and
(4) a window member 412. An exploded view of an embodiment of the
cable member 401 and waveguide 102 is depicted in FIG. 29.
[0305] Suitably, the inner surface of the opening 405 corresponds
in size and shape to at least part of the termination ferrule 407
(and interference member 408 attached thereto)--providing a close
fit between the termination ferrule 407 and the overmold member
404. In suitable operation, the waveguide 102 is held in place via
the termination ferrule 407 and the termination ferrule 407 and one
or more optical interfaces 120 are held in place via the overmold
member 404. In one embodiment, optical interfaces 120 may be
machine fit, pressed within the cable member 401 after molding or
overmolded into the overmold member 404. In another embodiment, the
configuration of the opening 405 and optical interfaces 120 may
allow an optical interface 120 to be held in a static position
during assembly 400 operation. As shown, the optical interface 120
is disposed across the entire opening 405 eliminating
electromagnetic radiation from propagating around the optical
interface 120.
[0306] As further shown in FIG. 28, a suitable interconnect member
402 includes (1) a main body 420, (2) an opening 421, (3) a window
member 422 suitably transparent at corresponding electromagnetic
frequencies, (4) an integrated circuit ("IC") 424, (5) a fluid
opening 426, (6) a cavity 427 in fluid communication with the fluid
opening 426, (7) a nose 429, e.g., a tapered nose, having an outlet
428 in fluid communication with the cavity 427 and in radiant
communication with the cable member 401 and (8) a connection member
430 attachable to the main body 420. In operation, the main body
420 is mated to the cable member 401 via opening 406. For example,
the main body 420 may be mated to the cable member 401 via a snap
fit connection including, but not necessarily limited to a detent
type snap action built into the main body 420 and cable member 401.
The interconnect member 402 is further depicted in the simplified
illustrations of FIGS. 30A-30D.
[0307] Again referring to FIG. 28, a hollow dispensing member 403
suitably includes a hub 440 having an inlet 441 and a hollow member
150 attached thereto having an outlet at its open tip 151--the
hollow member 150 being in communication with the hub 440. As
discussed above, the type of hollow member 150 that may be employed
is not limited to any one particular embodiment. As depicted in
FIG. 28, a suitable hollow dispensing member 403 is releasably
attachable to the connection member 430. In one simplified
embodiment, the connection member 430 may include a Luer lock type
device and the hollow dispensing member 403 may include a Luer lock
needle operationally compatible with the Luer lock 430 as
understood by the skilled artisan. With reference to FIGS. 30D and
31, the hub 440 of a Luer lock needle is operationally configured
to fit onto the outer surface of the nose 429 along the inner
perimeter of the Luer lock 430. An exemplary blunt Luer lock needle
is shown in FIG. 27. An exemplary sharp Luer lock needle is shown
in FIG. 28. As also understood by the skilled artisan, Luer lock
needles and other dispensing hollow members are typically
disposable items--the hollow member 150 often being constructed
from stainless steel and the hub 440 often being constructed from
plastic including, but not necessarily limited to polypropylene. As
discussed above, other hollow members 150 may be used, e.g., a
catheter or flexible catheter tube. An example of a suitable Luer
lock 430 is commercially available on the internet at
www.qosina.com.
[0308] Turning to FIG. 32, the longitudinal axis of the waveguide
102, cavity 427 and hollow member 150 of the treatment assembly 400
are axially aligned. In addition, the center of the optical
interface 120 is substantially aligned with the longitudinal axis
of each. In operation, the termination ferrule 407 is connected to
the cable member 401 in a manner whereby the distal end of the
waveguide 102 is set a predetermined distance (also may be referred
to as a precise distance, because distance may affect the focus,
e.g., the collimation, of electromagnetic radiation into fluid in
the interconnect member 402) from the optical interface 120 thereby
minimizing the distance of propagation of electromagnetic radiation
between the waveguide 102 and the optical interface 120. Although
the treatment assembly 400 may built to scale, in one suitable
embodiment the distal end of the waveguide 102 may lie from a
position of abutment with the optical interface 120 up to a precise
distance apart from the optical interface 120 during assembly 400
operation.
[0309] As described above, the main body 420 suitably mates with
the cable member 401 in a manner effective to minimize the distance
of propagation of electromagnetic radiation between the optical
interface 120 and the opening 421 of the interconnect member 402 in
a manner effective to maximize energy transfer from the waveguide
102 through the hollow dispensing member 403. As shown in FIGS. 31
and 32, the distal end of the overmold member 404 suitably abuts a
rim 425 disposed along the main body 420 when the component parts
are assembled for operation. In one suitable embodiment, the
opening 421 of the interconnect member 402 may lie from a position
of abutment with the optical interface 120 up to a predetermined
apart from the optical interface 120 during assembly 400 operation.
This distance suitably has no effect on assembly 400 operation. It
is further contemplated that the inner surface of the opening 421
may be coated with one or more anti-reflective optical coatings in
a manner effective to negate reflection losses of electromagnetic
radiation.
[0310] As light propagates from an electromagnetic radiation source
100 (see for example FIG. 1) through a waveguide 102, the numerical
aperture of the waveguide 102 defines the exit angle of
electromagnetic radiation from the waveguide 102 as the
electromagnetic radiation interfaces the optical interface, e.g.,
lens, 120. As electromagnetic radiation 126 enters the opening 421,
the electromagnetic radiation 126 propagates through the window
member 422 continuing through the cavity 427 and hollow member 150
exiting out there from toward a target site. A suitable window
member 422 may be constructed from one or more materials including,
but not necessarily limited to glass, synthetic quartz, polymeric
material, e.g., sapphire, and combinations thereof. In one
embodiment, the window member 422 may be machine fit, pressed in
after molding within the interconnect member 402 or overmolded into
the interconnect member 402 as desired. In another embodiment, the
configuration of the inner surface of the opening 421 and the
window member 422 may allow a window member 422 to be held in a
static position during assembly 400 operation. As shown, a suitable
window member 422 is disposed across the entire opening 421 sealing
off the cavity 427 in a manner whereby electromagnetic radiation
cannot propagate around the window member 422 and fluid cannot flow
beyond the window member 422 toward the optical interface 120. In
particular, the interconnect member 402, via window member 422, is
operationally configured to isolate the waveguide 102, optical
interface 120 and the air space adjacent the optical interface 120
from fluid or fluid solutions delivered to the optical interface
120 via fluid opening 426 (see Arrow F). In addition, the
interconnect member 402, via window member 422, is operationally
configured to isolate the waveguide 102 from the hollow dispensing
member 403.
[0311] When assembled, the IC 424, e.g., an encryption IC, or
authentication IC as the terms are known by persons of ordinary
skill in the art, is suitably attached to the surface of the main
body 420 or to a depression along the main body 420 via one or more
adhesive materials such as epoxy or the like. In operation, when
the main body 420 is mated with the second opening 406 of the cable
member 401, the IC 424 interfaces the electrical connector 409 of
the cable member 401, which is held intact via the PCB 410.
Suitably, the IC 424 electronically communicates assembly 400
operating information to the electrical connector 409 and PCB 410,
which in turn may electrically communicate operating information to
one or more LED 411 attached to the PCB 410 and/or to the
electromagnetic radiation source 100. In a simplified mode of
operation, the assembly 400 may be protected against counterfeiting
of component parts whereby, to initiate use of the assembly 400,
the IC 424 must electronically communicate with the electromagnetic
radiation source 100 to validate authenticity of the interconnect
member 402 before the electromagnetic radiation source 100 may be
operated. As understood by the skilled artisan, one or more of the
assembly 400 component parts and/or the electromagnetic radiation
source 100 may be programmed as desired. Suitably, PCB 410
communicates with the electromagnetic radiation source 100 via
wiring. Without limiting the invention, small gauge wiring from
about 0.00501 mm.sup.2 to about 0.0320 mm.sup.2 (from about 40 AWG
to about 32 AWG) may be used. In addition, wireless communication
between the assembly 400 and the source 100 may also be employed as
desired, e.g., via radio-frequency identification ("RFD").
[0312] In one suitable embodiment, the assembly 400 may include two
or more colored LED 411 for indicating various operation
information as desired. For example, one red LED and one blue LED
may be used to indicate certain operation information to one or
more persons through the window member 412 (see for example FIG.
31). In a non-limiting example of the assembly 400 including the
conveyance of light there through, a blinking red LED may indicate
a fault, a blinking blue LED may indicate active UV propagation and
a solid red LED may indicate active visible light propagation. A
suitable window member 412 may be constructed from glass, one or
more polymeric materials, synthetic quartz, and combinations
thereof. In addition, the window member 412 may be form fit within
an opening on the main body 420, held in place via one or more
adhesive materials or snap fit as desired.
[0313] Without limiting the means of production, a suitable
overmold member 404 and main body 420 may be formed via molds,
e.g., injection molding, overmold member 404 and the main body 420
being constructed from one or more materials as described below.
For human use, one or more bio-approved polymeric materials may be
used to construct the overmold member 404 and main body 420 as
desired. For example, in the United States of America, one or more
bio-approved polymeric materials may include materials as approved
by the United States Food and Drug Administration ("FDA") at such
time. In addition, the overmold member 404 and/or the interconnect
member 402 may be reused or disposable following a single use as
desired or as otherwise required.
[0314] As understood by the skilled artisan, the treatment device
106 and assemblies 200, 300, 400 discussed above may be constructed
from any material durable enough to perform one or more treatments
over one or more durations as described herein. In particular, the
treatment device 106 and assembly component parts may be
constructed of materials including but not necessarily limited to
those materials resistant to chipping, cracking, excessive bending
and reshaping as a result of ozone, weathering, heat, moisture,
other outside mechanical and chemical influences, as well as
various impacts and other loads placed on the treatment device 106
and assembly component parts. Likewise, the treatment device 106
and assembly component parts may be constructed from one or more
materials durable enough to withstand one or more of boiling,
autoclaving, dry heat sterilization, flaming, detergent washing,
bathing via an acid bath and combinations thereof for purposes of
reuse of the treatment device 106 and assembly component parts.
Also, the treatment device 106 and assembly component parts may
comprise any color or combination of colors, or in the alternative,
the treatment device 106 may be wholly or partly transparent and
translucent depending on individual preferences and needs.
[0315] Suitable treatment device 106 and assembly component parts
materials may include, but are not necessarily limited to metals,
polymeric materials, rubbers, glass, plexiglass, filled composite
materials, woods, minerals, and combinations thereof. Suitable
polymeric materials may include, but are not necessarily limited to
thermoplastics, synthetic plastics, semi-synthetic organic
plastics, and combinations thereof. Exemplary plastics may include,
but are not necessarily limited to nylon, vinyl polymers and
polyvinyl chloride ("PVC"), polyethylene, polyethylene
terephthalate ("PET"), polymethylpentene, polypropylene,
polycarbonate, and combinations thereof. In one particular
embodiment, the treatment device 106 and assembly component parts
may be constructed from one or more polymeric materials and one or
more pro-degradant additives effective to provide a degradable
treatment device 106 and assembly component parts. Suitable
pro-degradant materials may include, but are not necessarily
limited to one or more transition metal salts. Without limiting the
invention to a particular mode, the treatment device 106 and
assembly component parts may be produced via one or more processes
including, but not necessarily limited to assembly of various
parts, injection molding, blow molding, thermoforming, rotational
molding, compression molding, three-dimensional printing, film and
sheet extrusion, and pipe and cable extrusion as each is understood
by a skilled artisan.
[0316] A suitable waveguide 102 or radiant energy conduit is
effective to guide or otherwise convey electromagnetic radiation
there through at one or more rates of attenuation as desired. For
the purposes of this application, suitable waveguides 102 may
include, but are not necessarily limited to liquid light guides,
glass optical fibers, plastic optical fibers, photonic-crystal
fibers ("PCF"), and combinations thereof. Suitable liquid light
guides may include any desired liquid transmissive fluid
encapsulated therein as desired. For the purposes of this
application, liquid light guides are operationally configured to
convey radiant energy from about 200 nm to about 2000 nm. Suitable
glass optical fibers may be constructed from materials including,
but not necessarily limited to silica glass, e.g., germanosilicate
or aluminosilicate glass, fluoride glass, e.g., fluorozirconate and
fluoroaluminate, chalcogenide glass, phosphate glasses, crystalline
materials such as sapphire, and combinations thereof. Suitable
plastic optical fibers may be constructed from materials including,
but not necessarily limited to poly(methyl methacrylate) ("PMMA").
For conveying radiant energy to a subsurface or subcutaneous
location of an animal, a suitable waveguide 102 has an attenuation
coefficient of about 0.5 dB/m or lower. Without limiting the
invention to a particular mode of operation, one suitable waveguide
102 includes a fused silica UV grade fiber commercially available
from Molex, Inc., which may be located on the internet at the
following address: www.molex.com.
[0317] Without limiting the invention, optical fibers may further
be described according to the following: [0318] Fiber couplers may
be employed to couple radiant energy between two fibers, typically
with the coupling coefficient depending on the optical wavelength;
[0319] As understood by the skilled artisan Fiber Bragg gratings
may be employed to provide various wavelength-dependent reflection
and transmission properties--such may be used as optical filters or
for introducing chromatic dispersion into a system; [0320] Fiber
polarizers may be employed for guiding only electromagnetic
radiation with a certain polarization direction; [0321] Fiber
amplifiers may be employed for amplifying electromagnetic radiation
in certain wavelength regions; [0322] Various types of optical
modulators such as electroabsorption modulators and electro-optic
modulators may be employed; [0323] Faraday isolators, optical
isolators, or optical diodes, may be employed including the use of
collimation optics; [0324] Fiber-optic switches as understood by
the skilled artisan may be employed; [0325] Mechanical splices may
be employed as desired; [0326] Double-clad fibers may be employed
as desired; and [0327] Polarization-maintaining fibers and photonic
crystal fibers may be employed as desired.
[0328] As desired, one or more connections may be employed to
assist in the conveyance of electromagnetic radiation from the
electromagnetic radiation source 100 to the waveguide 102 and to
the treatment device 106 or assemblies 200, 300, 400. Suitable
connections may be operationally configured to engage each of the
electromagnetic radiation source 100, waveguide 102 and treatment
device 106 in a manner effective to maintain substantially all of
the electromagnetic radiation within the system components free of
leakage thereof during operation. The connections may include
optical fiber connectors, optical fiber couplers, luer fittings or
adapters, ferrule connectors, compression fittings, and
combinations thereof. As one simplified example, the conduit 134 in
FIG. 14A may include a luer-lock connector 137 and cap 138 for
receiving a fluid conduit 107 in fluid communication thereto.
Suitable optical fiber connectors include, but are not necessarily
limited to FC connectors, E2000 connectors, LuxCis connectors, SMA
905 connectors, ST connectors, and TOSLINK connectors as each are
understood by the skilled artisan. Suitable connections may be
constructed from metals, polymeric materials, rubbers, glass,
plexiglass, filled composite materials, and combinations thereof.
Metal connection materials may include, but are not necessarily
limited to stainless steel, brass, nickel-plated brass, aluminum,
copper, and combinations thereof. Plastic connection materials may
include nylon, vinyl polymers and polyvinyl chloride ("PVC"),
polyethylene, polyethylene terephthalate ("PET"),
polymethylpentene, polypropylene, polycarbonate, and combinations
thereof.
[0329] The electromagnetic radiation source 100, as shown in FIGS.
1 and 2, may derive radiant energy from one or more sources as
desired. Suitable sources of radiant energy may include, but are
not necessarily limited to (1) one or more incandescent lamps or
bulbs (which can have one or more rotating filters around each
bulb), (2) one or more semiconductor light sources (including but
not necessarily limited to light-emitting diodes "LED"), (3) one or
more diode laser lights, (4) one or more quartz-halogen lights, (5)
one or more gas-discharge lamps, and combinations thereof. A
suitable electromagnetic radiation source 100 is operationally
configured to produce electromagnetic radiation across the entire
electromagnetic spectrum. Without limiting the invention to a
particular embodiment, the electromagnetic radiation source 100 may
be self-powered, e.g., battery power, or powered by an external
source, e.g., a wall outlet and the like.
[0330] Without limiting the application to a particular embodiment,
the electromagnetic radiation source 100 of the present application
may include an electromagnetic radiation source 100 as described in
U.S. patent application Ser. No. 11/686,767 filed on Mar. 15, 2007
or U.S. patent application Ser. No. 13/783,387 filed on Mar. 3,
2013, which are hereby incorporated by reference in their entirety.
A suitable electromagnetic radiation source 100 may include one or
more of the following components:
[0331] (1) UV LEDS: The main LED may include a high power 365 nm
version as commercially available from Nichia Corporation. To fill
in lower wavelength UV energy UVTOP LEDs may be used in wavelengths
from about 295 nm to about 310 nm. Such LEDs are commercially
available from Sensor Electronic Technology, Inc. Suitably, light
is coupled from each of these LED sources directly into a 600 um
fiber or the like. This is done via a process using a ball-lensed
fiber that uses a precision 3-axis stage to optimize the coupling.
Each LED and fiber assembly is connected into an SMA 905 fiber
optic connector (as understood by the skilled artisan) so that
individual LEDs can be serviced as necessary;
[0332] (2) UV Fiber Optics: One suitable fiber may include a 600 um
core size. The fibers are terminated in a "Y" fashion. Such design
allows close to about 50.0% of the fiber coupled from each fiber to
be coupled into the next fiber. Such configuration results in about
25.0% of the optical power from each LED making it to the beam
splitter as such is understood by the skilled artisan. Mechanical
and optical data for suitable fibers, including Polymicro optical
fibers, is commercially provided by Molex Incorporated;
[0333] (3) Fused Silica UV Lenses (inside a collimator): The light
emitted from the fiber is collimated for transmission through the
beam-splitter. There is a reciprocating collimator on the output
side of the beam-splitter used to focus the light back into the
output fiber. Information on the UV grade fused silica and plano
convex lenses that may be employed herein is commercially available
from Edmund Optics, Inc.;
[0334] (4) UV Short Pass Filter: A dichroic filter may be used to
combine the visible LED and UV-LEDs. Suitably, the wavelengths that
are not transmitted are reflected;
[0335] (5) Visible LED and LED optic: As understood by the skilled
artisan a CREE Cool White LED may be used as is commercially
available from Cree, Inc. Another bright single die LED may be used
as desired. Suitably, an acrylic injection molded lens is used to
collimate the light from the LED, this reflects from the
beam-splitter and is focused into the output fiber; and
[0336] (6) Feedback Photodiode: A feedback photodiode may be used
to measure the output of the UV-LEDs and calibrate the power output
prior to every usage or treatment using the radiation source. As
understood by the skilled artisan, the photodiode receives a small
reflection from the beam splitter.
[0337] FIG. 33 illustrates a first non-limiting "all in one" type
self-powered treatment device 500 operationally configured to
produce and convey electromagnetic radiation and fluid to one or
more target sites. In this simplified illustration, the treatment
device 500 includes a power source 510, an electromagnetic
radiation source 520, one or more optical interfaces 530 for
transforming electromagnetic radiation entering the waveguide 540,
a fluid inlet 550 and at least a second optical interface 560 used
alone or with another window type member similar to the embodiments
described above, e.g., effective for sealing off fluid flow toward
the one or more optical interfaces 530. In one embodiment, the
electromagnetic radiation source 520 may include a single radiant
energy source, an LED array, or array of other radiant energy
sources as desired. In suitable operation, the treatment device 500
is operationally configured to convey electromagnetic radiation
and/or one or more fluids or fluid solutions out through the distal
end of the hollow member or hollow puncture forming member 150 that
is in radiant and fluid communication thereto. In another
embodiment, other optic configurations including those described
above may be employed into the present treatment device 500. In
another embodiment it is also contemplated that the treatment
device 500 be powered via a power cord similar to other electronic
appliance type devices and the like. In another embodiment, the
treatment device 500 may include a fluid storage compartment in
fluid communication with the hollow member 150. The treatment
device 500 may be operationally configured to make use of
disposable type hollow members or hollow puncture forming members
150 as described herein.
[0338] Turning now to the simplified illustration of a treatment
device 106 in FIG. 34, it is further contemplated that one or more
outer surfaces of the treatment device 106 may include a mating
type surface for contacting the treatment device 106 with one or
more target surfaces. Such surfaces may include one or more shapes
or surface configurations as desired. For example, a treatment
device 106 may include a curved surface operationally configured to
be set atop a curved target surface. Such surfaces may also include
one or more raised surface portions raised above adjacent areas for
providing a slip-resistant surface. In the embodiment of FIG. 34,
the treatment device 106 is shown as having a substantially planar
mating surface. As further illustrated in FIG. 34, the mating
surface may include one or more adhesives providing an adhesive
type surface 180 covered by a peelable layer 182. In an embodiment
where the treatment device 106 of FIG. 34 is configured for human
treatment as shown in FIG. 1, it is contemplated that the adhesive
type surface 180 may be placed onto the skin of a person's arm
whereby the adhesive material is operationally configured to
maintain the treatment device 106 in a substantially fixed position
on the arm. Suitable adhesive type surfaces may include one or more
tacky substances as understood by the skilled artisan. In one
particular embodiment, removal of the treatment device 106 from a
subject's skin should not cause injury, pain or discomfort to the
individual. Similar to other embodiments of the treatment device
106 and treatment assemblies, the treatment device of FIG. 34 may
include two or more inlets or ports as desired for receiving
electromagnetic radiation from waveguides 102 communicating with
each such inlet or port. Likewise the treatment device 106 of FIG.
34 may be reusable, replacing only the hollow member or hollow
puncture forming member 150 following each use of the treatment
device 106.
[0339] It is further contemplated that the treatment devices and
assemblies of this application may include one or more sensor type
devices operationally configured to detect the spatial relationship
between the sensor and a target surface of a subject. Such sensors
provide a safety feature preventing operation of the treatment
devices and/or treatment assemblies as desired. Suitable sensors
include, but are not necessarily limited to projected field
sensors, proximity sensors, projected capacitive sensors, and
combinations thereof. Other suitable sensors may be described as
being operationally configured to detect a target surface of a
subject through a non-electrically conductive medium.
[0340] It is further contemplated that treatment devices and
assemblies of this application may include one or more filter type
members for filtering out solids, pathogens, and combinations
thereof prior to the fluids and fluid solutions flowing to a common
area of the devices and assemblies (for example see cavity 427).
For example, in an emergency situation a device, assembly or system
of this application including one or more filter type members may
be used in a remote area making use of contaminated water as the
fluid source. One suitable filter type member may be operationally
configured to remove chlorine, heavy metals including aluminum,
arsenic, cadmium, copper, lead, mercury, iodine, endrin,
dichlorodiphenyltrichloroethane, lindane, heptachlor,
polychlorinated biphenyls, atrazine, simazine, nitrite,
bromodichloromethane, bromoform, benzene, dibromochloromethae,
carbon tetrachloride, ethyl benzene, methyl tert butyl ether,
trichloroethane, toluene, xylene, giardia, crytoporidium, E. Coli,
E. Faecalis, and combinations thereof. In addition to the above, a
suitable filter type member may also be operationally configured to
provide 99.9999 percent reduction of bacteria, cysts and
viruses.
[0341] In one embodiment, the application may be directed to a
method of targeting an animal blood vessel with electromagnetic
radiation and fluid including (1) providing an assembly including
(A) a device having a first inlet for connecting to a source of
electromagnetic radiation, a second inlet for connecting to a
source of fluid and an outlet for emitting electromagnetic
radiation and fluid received from the electromagnetic radiation and
fluid sources, the device being operationally configured to
transform the electromagnetic radiation received therein and
isolate the fluid received therein from the electromagnetic
radiation source and (B) a hollow member attached to the outlet of
the device, the hollow member having an open puncture forming
distal end; (2) connecting the device to an electromagnetic
radiation source and a fluid source; (3) directing the distal end
of the hollow puncture forming member into a blood vessel; and (4)
conveying transformed electromagnetic radiation and fluid out
through the distal end of the hollow member into the blood vessel.
In another embodiment, the application may be directed to a device
for targeting one or more sites with electromagnetic radiation, the
device having a housing operationally configured to convey
electromagnetic radiation and fluid there through, the housing
having a first inlet for receiving electromagnetic radiation from
one or more sources, a second inlet for receiving fluid from one or
more sources and an outlet for emitting electromagnetic radiation
and fluid received through the first and second inlets; the housing
being operationally configured to fluidly seal the first inlet from
the second inlet and transform electromagnetic radiation received
through the first inlet.
[0342] It is believed that the devices, assemblies, systems and
methods of the present application and advantages will be
understood by the foregoing description. Persons of ordinary skill
in the art will recognize that many modifications may be made to
the present application without departing from the spirit and scope
of the devices, assemblies, systems and methods. The embodiment(s)
described herein are meant to be illustrative only and should not
be taken as limiting the invention, which is defined in the
claims.
* * * * *
References