U.S. patent application number 15/505058 was filed with the patent office on 2017-09-21 for apparatus for forming delivery path for composition for treatment and auxiliary assembly for skin treatment including same.
The applicant listed for this patent is LUTRONIC CORPORATION. Invention is credited to Bon Cheol GOO, Tae Ho HA.
Application Number | 20170266426 15/505058 |
Document ID | / |
Family ID | 55350965 |
Filed Date | 2017-09-21 |
United States Patent
Application |
20170266426 |
Kind Code |
A1 |
HA; Tae Ho ; et al. |
September 21, 2017 |
APPARATUS FOR FORMING DELIVERY PATH FOR COMPOSITION FOR TREATMENT
AND AUXILIARY ASSEMBLY FOR SKIN TREATMENT INCLUDING SAME
Abstract
The present invention relates to an apparatus for forming a
delivery path for a composition for treatment and an auxiliary
assembly for skin treatment including the same, and provides an
apparatus for forming a delivery path for a composition for
treatment and an auxiliary assembly for skin treatment including
the same, the apparatus comprising: a light source; a light
irradiating unit for receiving a light from the light source to
irradiate the light on a surface of skin; and a control unit for
controlling a pulse waveform of a light irradiated through the
light irradiating unit so as to form a plurality of pores, which
form a path through which a composition applied on the surface of
the skin is transferred inside, on the surface of the skin after
irradiating the light.
Inventors: |
HA; Tae Ho; (Goyang, KR)
; GOO; Bon Cheol; (Seoul, KR) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
LUTRONIC CORPORATION |
Goyang |
|
KR |
|
|
Family ID: |
55350965 |
Appl. No.: |
15/505058 |
Filed: |
August 19, 2015 |
PCT Filed: |
August 19, 2015 |
PCT NO: |
PCT/KR2015/008667 |
371 Date: |
February 17, 2017 |
Current U.S.
Class: |
1/1 |
Current CPC
Class: |
A61K 31/728 20130101;
A61K 8/671 20130101; A61K 8/676 20130101; A61K 8/42 20130101; A61K
8/0245 20130101; A61K 8/68 20130101; A61M 37/00 20130101; A61Q
19/00 20130101; A61K 8/0225 20130101; A61B 18/203 20130101; A61K
8/41 20130101; A61K 8/0295 20130101; A61K 31/195 20130101; A61M
2037/0007 20130101; A61B 2018/0047 20130101; A61K 8/375 20130101;
A61K 8/735 20130101; A61K 2800/81 20130101; A61K 8/44 20130101;
A61K 31/07 20130101; A61M 2202/064 20130101; A61K 31/375
20130101 |
International
Class: |
A61M 37/00 20060101
A61M037/00; A61K 8/41 20060101 A61K008/41; A61B 18/20 20060101
A61B018/20; A61K 8/73 20060101 A61K008/73; A61Q 19/00 20060101
A61Q019/00; A61K 8/02 20060101 A61K008/02; A61K 8/67 20060101
A61K008/67; A61K 8/42 20060101 A61K008/42 |
Foreign Application Data
Date |
Code |
Application Number |
Aug 19, 2014 |
KR |
10-2014-0108006 |
Claims
1. An apparatus for forming a delivery path for a composition for
treatment, the apparatus comprising: a light source; a light
irradiating unit for receiving a light from the light source to
irradiate the light on a surface of skin; and a control unit for
controlling a pulse waveform of a light irradiated through the
light irradiating unit so as to form a plurality of pores, which
form a path through which a composition applied on the surface of
the skin is transferred inside, on the surface of the skin after
irradiating the light.
2. The apparatus of claim 1, wherein the light irradiated through
the light irradiating unit forms a plurality of pores having a
diameter of 200 .mu.m or less on the surface of skin.
3. The apparatus of claim 2, wherein the pores are formed up to a
target tissue located inside of the skin from the surface of
skin.
4. The apparatus of claim 1, wherein the light irradiated through
the light irradiating unit has a wavelength in a range of 1800 nm
or higher to 2000 nm or less.
5. The apparatus of claim 1, wherein the light is constituted to
comprise laser diode.
6. The apparatus of claim 1, wherein the composition is prepared by
mixing a powder-type preparation with a solvent followed by
stirring.
7. The apparatus of claim 6, wherein the powder-type preparation
has a cubosome-type structure.
8. The apparatus of claim 1, wherein the composition is constituted
to comprise only one selected from the group consisting of vitamin
C, retinol, tranexamic acid, ceramide, and hyaluronic acid.
9. A composition for skin treatment, which comprises a powder-type
preparation and a solvent for dissolving the powder-type
preparation and is applied on the skin, wherein pores were formed
by laser, and transferred inside of the skin.
10. The composition of claim 9, wherein the powder-type preparation
has a cubosome-type structure.
11. The composition of claim 9, wherein the composition comprises
one selected from the group consisting of vitamin C, retinol,
tranexamic acid, ceramide, and hyaluronic acid.
12. An auxiliary assembly for skin treatment, the assembly
comprising: a stirrer for preparing a composition for treatment by
stirring a powder-type preparation and a solvent; and an apparatus
for forming a delivery path for a composition, which comprises a
light source; a light irradiating unit for receiving a light from
the light source to irradiate the light on a surface of skin; and a
control unit for controlling a pulse waveform of a light irradiated
through the light irradiating unit so as to form a plurality of
pores, which form a path through which the composition for
treatment is applied and transferred inside, on the surface of the
skin.
13. The auxiliary assembly of 12, wherein the apparatus for forming
a delivery path for a composition is configured to form pores
having a diameter of 200 .mu.m or less on the surface of the
skin.
14. The auxiliary assembly of 13, wherein the pores are formed from
the surface of the skin to a target tissue.
15. A method for skin treatment, the method comprising: a step of
forming a plurality of pores on a surface of skin using an
apparatus for forming a delivery path for a composition for
treatment; a step of preparing a composition for treatment by
stirring a powder-type preparation and a solvent; and a step of
applying the composition for treatment on the surface of the skin
to inject the composition for treatment to be injected into the
plurality of pores.
Description
BACKGROUND OF THE INVENTION
[0001] Field of the Invention
[0002] The present invention relates to an apparatus for forming a
delivery path for a composition for treatment and an auxiliary
assembly for skin treatment including the same, and more
specifically, to an apparatus for forming a delivery path for a
composition for treatment for improving skin absorption of a
composition for treatment and an auxiliary assembly for skin
treatment including the same.
[0003] Related Art
[0004] Recently, with a growing interest in skin, the interest in
compositions for skin treatment for protecting skin and improving
skin conditions is also significantly increasing. These
compositions for skin treatment employ various components and thus
various functional products specialized for skin characteristics,
skin lesions, or purposes of improvement are being developed.
Recently, cosmeceutical products including professional therapeutic
functions beyond the realm of simple functional cosmetics are being
developed.
[0005] Generally, compositions for skin treatment are used in such
a manner they are applied on a skin surface of a patient. Then,
part of the applied compositions for skin treatment is absorbed
into skin tissue and involved in skin improvement.
[0006] However, in conventional cases, the percentage that a given
composition applied on a skin surface arrived at a target tissue
such as a dermal layer was about less than 5% and thus it was
difficult to achieve a sufficient effect for the amount of use. In
particular, in the case of cosmeceutical compositions where
functionalities are emphasized, the percentage of components
substantially involved in the functions accounts for is about 1%
relative to the total composition, and the percentage that
substantially contributes to skin improvement is only 0.05% or less
and thus there was a problem in that the efficiency is
significantly lowered.
SUMMARY OF THE INVENTION
[0007] The present invention, in order to solve the above problems,
provides an apparatus for forming a delivery path for a composition
for treatment, that forms a delivery path through which the
composition is delivered, on a surface of skin so that the
composition for skin treatment is effectively delivered to a target
position thereby maximizing the therapeutic effect, and an
auxiliary assembly for skin treatment including the same.
[0008] To achieve the objects, the present invention provides an
apparatus for forming a delivery path for a composition for
treatment, which includes a light source; a light irradiating unit
for receiving a light from the light source to irradiate the light
on a surface of skin; and a control unit for controlling a pulse
waveform of a light irradiated through the light irradiating unit
so as to form a plurality of pores, which form a path through which
a composition applied on the surface of the skin is transferred
inside, on the surface of the skin after irradiating the light.
[0009] In particular, the light irradiated through the light
irradiating unit may be configured so that pores having a diameter
of 200 .mu.m or less can be formed on the surface of the skin.
These pores may be formed so that they can be extended from the
surface of the skin to a dermal tissue.
[0010] The light irradiated through the light irradiating unit may
be configured to have a wavelength in a range of 1800 nm or higher
to 2000 nm or less. In particular, the light source of the light
irradiating unit may be configured to include laser diode.
[0011] Additionally, the composition described above may be
prepared by mixing a powder-type preparation with a solvent
followed by stirring. The powder-type preparation may be formed to
have a cubosome-type structure.
[0012] In particular, the composition described above may consist
of only one selected from vitamin C, retinol, tranexamic acid,
ceramide, and hyaluronic acid.
[0013] Meanwhile, the object of the present invention described
above may also be achieved by a composition for skin treatment,
which consists of a powder-type preparation and a solvent for
dissolving the powder-type preparation, applied to the skin where
pores were formed by laser, and is transferred inside of the
skin.
[0014] Furthermore, the object of the present invention described
above may also be achieved by an auxiliary assembly for skin
treatment, which includes: a stirrer for preparing a composition
for treatment by stirring a powder-type preparation and a solvent;
and an apparatus for forming a delivery path for a composition for
treatment, which includes a light source; a light irradiating unit
for receiving a light from the light source to irradiate the light
on a surface of skin; and a control unit for controlling a pulse
waveform of a light irradiated through the light irradiating unit
so as to form a plurality of pores, which form a path through which
the composition for treatment is applied and transferred inside, on
the surface of the skin.
[0015] Lastly, the object of the present invention described above
may also be achieved by a method for skin treatment, wherein the
method includes: a step of forming a plurality of pores on a
surface of skin using an apparatus for forming a delivery path for
a composition for treatment; a step of preparing a composition for
treatment by stirring a powder-type preparation along with a
solvent; and a step of applying the composition for treatment on
the surface of the skin so that the composition for treatment can
be injected into the plurality of pores.
[0016] According to the present invention, a delivery path for a
composition for treatment is formed by an apparatus for forming a
delivery path for a composition for treatment and an auxiliary
assembly for skin treatment, and thus the composition can be easily
transferred up to a target tissue along the path. Therefore, the
present invention has an advantage in that the effects of treating
and improving skin can be maximized even by using a small
amount.
BRIEF DESCRIPTION OF THE DRAWINGS
[0017] FIG. 1 is a schematic diagram illustrating an auxiliary
assembly for skin treatment according to an embodiment of the
present invention;
[0018] FIG. 2 is a schematic diagram illustrating the process of
preparing a composition for skin treatment using a stirrer of FIG.
1;
[0019] FIG. 3 is a block diagram schematically illustrating the
constitution of the apparatus for forming a delivery path for a
composition for treatment of FIG. 1;
[0020] FIG. 4 is a cross-sectional diagram illustrating the feature
of the delivery of a composition for skin treatment;
[0021] FIG. 5 is a flowchart illustrating a method for skin
treatment; and
[0022] FIG. 6 is a flowchart illustrating a method for preparing a
powder-type preparation.
DESCRIPTION OF EXEMPLARY EMBODIMENTS
[0023] Hereinafter, an apparatus for forming a delivery path for a
composition for treatment according to an embodiment of the present
invention and an auxiliary assembly for skin treatment including
the same will be explained in detail with reference to the
accompanying drawings. In the explanation below, the positional
relationship between each of constituting elements is explained in
principle based on the drawings. Additionally, the drawings may be
indicated by simplifying or exaggerating when necessary, the
structure of the present invention for the convenience of the
explanation. Accordingly, it is obvious that the scope of the
present invention should not be limited thereto but the present
invention may be embodied by adding, modified, or omitting various
apparatuses.
[0024] FIG. 1 shows an auxiliary assembly for skin treatment
according to an embodiment of the present invention. As illustrated
in FIG. 1, the auxiliary assembly for skin treatment 10 is
configured to include a stirrer 100 and an apparatus for forming a
delivery path for a composition for treatment 200.
[0025] In particular, the stirrer 100 is an apparatus for preparing
a composition for treatment by a user. Since the auxiliary assembly
for skin treatment 10 is provided to include the stirrer 100, the
user can directly prepare the composition for treatment in a place
for operation before the user operates the procedure.
[0026] Additionally, the apparatus for forming a delivery path for
a composition for treatment 200 is an apparatus for forming a path
for the composition for treatment to be delivered inside of skin,
and such a path can be formed on a patient's skin using light.
[0027] Hereinafter, referring to FIGS. 2 to 4, the stirrer and the
apparatus for forming a delivery path for a composition for
treatment will be explained in more detail.
[0028] FIG. 2 is a schematic diagram illustrating the process of
preparing a composition for skin treatment using the stirrer of
FIG. 1.
[0029] As illustrated in FIG. 2, the material for treatment may be
provide in the form of a powder-type preparation 20. The
powder-type preparation 20 is constituted to include a component
material for skin treatment. For example, the powder-type
preparation may be constituted to include at least one among
vitamin C, retinol, tranexamic acid, ceramide, and hyaluronic acid,
which have skin treatment effects.
[0030] For example, in an embodiment, the powder-type preparation
may be prepared in 5 different kinds, which includes a powder-type
preparation including hyaluronic acid, a powder-type preparation
including vitamin C, a powder-type preparation including retinol, a
powder-type preparation including tranexamic acid, and a
powder-type preparation including ceramide. Accordingly, a user can
prepare a composition to be used for treatment by selecting any one
from the 5 different kinds of powder-type preparations, in
consideration of the lesions and therapeutic steps of a
patient.
[0031] As described above, when a composition for treatment is
prepared to proceed with a treatment being focused on a single
component in an embodiment of the present invention, any one from
the 5 different kinds of powder-type preparations is selected to be
used, but the composition for treatment may be prepared by
selecting at least two from the 5 different kinds of powder-type
preparations, according to the user's selection.
[0032] The powder-type preparations 20 may be preparations which
are configured to have a cubosome structure including a single
active ingredient. Cubosome is a kind of nanoparticle made of
glyceryl monooleate (GMO), which is a biocompatible material.
Cubosome has a cubic structure in an aqueous solution due to its
molecular structural specificity and has a bicontinuous aqueous
channel. The drug delivery efficiency can be improved while
maintaining human-friendliness by preparing the active ingredient
into the nanoparticle (see FIG. 2).
[0033] The stirrer 100 is an apparatus for preparing a composition
for treatment using the powder-type preparations, and it may
consist of a vortex mixer. Accordingly, a user can prepare a
composition for treatment 40 in a serum type by injecting the
selected powder-type preparation 20 of a single ingredient and a
separately-provided solvent (e.g., distilled water) into a stirrer
100 followed by stirring. The thus-prepared composition for
treatment 40, being in a blended state where the powder-type
preparation is dissolved in a solvent, includes particles in the
form of a cubosome, and these particles may be configured to have a
diameter of 200 .mu.m or less.
[0034] The stirrer 100 may be provided as one of the constituting
elements that constitutes the auxiliary assembly for skin treatment
10 but is not limited thereto and it is possible to use a
self-provided stirrer.
[0035] FIG. 3 is a block diagram schematically illustrating the
constitution of the apparatus for forming a delivery path for a
composition for treatment of FIG. 1. As illustrated in FIG. 3, the
apparatus for forming a delivery path for a composition for
treatment 200 is configured to include a light source 210, a light
irradiating unit 230, and a control unit 220.
[0036] The light source 210 generates light which is irradiated
through the light irradiating unit 230. In an embodiment of the
present invention, the apparatus for forming a delivery path for a
composition for treatment 200 forms a delivery path on a surface of
skin using laser, and accordingly, the light source 210 is
configured to produce laser. More specifically, the light source
210 has excellent reactivity to water and can thus be configured to
generate laser having a wavelength of 1500 nm or higher, which
enables to form pores when irradiated on skin.
[0037] The light source 210 may be provided inside of the main body
201 of the apparatus for forming a delivery path for a composition
for treatment 200. The light source 210 may be configured in
various structures, and in an embodiment of the present invention,
for example, the light source 210 may be configured by using laser
diode which irradiates a laser having a wavelength of 1927 nm.
However, in addition, design modification of the light source in
various methods is possible, for example, the light source may be
configured to be provided within the handpiece instead of the main
body, and the light source may be configured to generate light
having a wavelength of 1550 nm or in a range of 2700 nm to 2900 nm,
etc.
[0038] The light irradiating unit 230 has a constitution that the
light produced in the light source 210 is irradiated and the light
irradiated through the light irradiating unit 230 is irradiated to
a surface of a patient's skin. A light fiber 203 and/or a plurality
of optical elements 204 are disposed between the light irradiating
unit 230 and the light source 210 and they form a path for the
progress of the light. According to the structure illustrated in
FIG. 1, the light irradiating unit 230 is formed at the end of the
handpiece 202. Accordingly, a user can proceed with the treatment
in a state where the light irradiating unit 230 is disposed on the
patient's skin by grapping the handpiece 202.
[0039] The light irradiated through the light irradiating unit 230
may be configured to irradiate light to a single location in a
state that the handpiece 202 is being fixed, and may be configured
to irradiate light on multiple locations within a region where the
handpiece 202 is located.
[0040] However, since the configuration of the light source 210 is
generally similar to that of an optical treatment apparatus for
skin treatment, the detailed explanation is omitted herein
below.
[0041] Meanwhile, the control unit 220 of the apparatus for forming
a delivery path for a composition for treatment 200 controls the
operation details of each constituting element including the light
source 210 and the light irradiating unit 230. In particular, the
control unit 220 is configured to control the operation details of
the light source 210 and the light irradiating unit 230 according
to the details of the input signal or predetermined mode by a user,
and to control the output of the light being irradiated through the
light irradiating unit 230, spot size, and the pulse waveform of
light. Accordingly, the control unit can form pores, which become
the delivery path of a composition for treatment, on a surface of
skin by irradiating light through the control of the light source
210 and the light irradiating unit 230.
[0042] FIG. 4 is a cross-sectional diagram illustrating the feature
of the delivery of a composition for skin treatment. As illustrated
in FIG. 4 (a), the light irradiated through the light irradiating
unit can be irradiated to a surface of a patient's skin thereby
forming pores (h). In particular, the spot size of the light
irradiated may be controlled to have a diameter of 200 .mu.m or
less, and as such, pores having a diameter in a range of 50 .mu.m
or higher to 200 .mu.m or less may be formed on a surface of skin.
When the size of the pores formed on the skin surface is within the
above range, a path through which a composition for treatment can
be delivered can be formed, and it is possible to have a rapid
recovery without additional skin damage or scar after the
procedure.
[0043] In particular, the control unit 220 can control the output
or pulse waveform of light so that the pores formed on the skin
surface may have a depth to be extended to a target position (e.g.,
a dermal tissue). In particular, it is possible to control the
light irradiated through the light irradiating unit 230 to form
pores with a corresponding depth by a single irradiation, and it is
also possible to control to form pores with a corresponding depth
by irradiating multiple shots on a single location.
[0044] When a plurality of pores extended to a target position from
a patient's skin surface are formed by the method described above,
the composition for treatment 40 may be delivered to a target
tissue through the pores and absorbed in the target position (see
FIG. 4(b)). Accordingly, there is an advantage in that the
efficiency of delivering the composition for skin treatment can be
significantly improved.
[0045] However, although the apparatus for forming a delivery path
for a composition for treatment 200 was explained above being
focused on the function of forming a delivery path of a composition
for treatment on a surface of skin, it is also possible to utilize
the apparatus for optical treatment of skin lesions by the control
of the control unit 220. For example, in the case of a laser having
a wavelength of 1927 nm in an embodiment of the present invention,
due to its high water absorptivity, it is possible to treat melanin
while minimizing skin damage, and thus it is possible to control to
optically treat skin, in addition to the method of pore formation
on a skin surface, by configuring the control unit 220 to enable
the control of the light source 210 and the light irradiating unit
230.
[0046] FIG. 5 is a flowchart illustrating a method for skin
treatment. Hereinafter, a method for skin treatment by applying a
composition for skin treatment using the auxiliary assembly for
skin treatment described above is explained in detail.
[0047] First, a step of forming a plurality of pores on a surface
of a patient's skin using the apparatus for forming a delivery path
for a composition for treatment 200 is performed (S10). This step
is performed in such a manner that a user breaks the handpiece 202,
fixes it on a skin surface of a patient who requires treatment, and
irradiates light through the light irradiating unit 230. The light
irradiated through the light irradiating unit is controlled to form
pores having a diameter in a range of 50 .mu.m or higher to 200
.mu.m or less. Additionally, the pores may be formed to have a
depth to be extended to a target tissue to which the composition
for treatment is to be delivered. These pores may form a path (h)
through which the composition for treatment is transferred inside
of skin, after this step.
[0048] A step of preparing a composition for treatment may be
performed (S20). In FIG. 5, this step is shown following the step
of forming pores described above, however, this step is a step
performed separately from the step of forming pores, and this step
may possibly be performed before the step of forming pores, may
possibly be performed after the step of forming pores, and may
possibly be performed simultaneously by other workers.
[0049] In this step, a composition for treatment 40 is prepared
using the powder-type preparations 20 provided in a pre-prepared
form. These powder-type preparations are configured to have a
cubosome structure and they may be those which include one from
vitamin C, retinol, tranexamic acid, ceramide, and hyaluronic acid,
as an active ingredient. A user may prepare a composition for
treatment by selecting one from the 5 kinds of powder-type
preparations having different active ingredients as described
above, in consideration of the skin conditions and treatment steps
of a patient.
[0050] In this step, a user injects the selected powder-type
preparation 20 along with distilled water, which corresponds to a
solvent, to a stirrer 100. Then, the selected powder-type
preparation 20 and the solvent are dissolved by stirring for 3 to 5
minutes using a stirrer. As such, a composition for treatment 40 in
a serum type is prepared. The thus-prepared composition for
treatment includes particles having a cubosome structure. These
particles may be configured to have a diameter of 200 .mu.m or
less. As such, the composition for treatment is not distributed in
a pre-prepared from but is directly prepared via on-site production
by a user immediately before skin treatment. Accordingly, there is
an advantage in that the treatment can be proceeded in a state
where the effect of the composition for treatment is in an optimal
state.
[0051] Meanwhile, when a composition for treatment is completed by
going through with the steps described above and pores are formed
on a skin surface of a patient, the user proceeds with a step of
applying the prepared composition for treatment on the skin surface
of a patient (S30). The composition for treatment applied on the
skin surface of a patient can be delivered to a target tissue
through the delivery path formed by the pores (h) on the skin
surface and absorbed by the target tissue.
[0052] As described above, the present invention provides an
auxiliary assembly for skin treatment capable of improving the
therapeutic effect using a composition for treatment in proceeding
with skin treatment, and a method for treatment using the same.
[0053] As such, the path through which the composition for
treatment is directly delivered to the target tissue is formed
through the pretreatment process. In this case, a significantly
higher amount of the composition for treatment can be delivered to
the targeted position even when a small amount of the composition
is used, compared to when the composition for treatment penetrates
the skin and then arrives at the target tissue thus being capable
of improving the therapeutic effect. Additionally, due to the use
of the composition for treatment after the direct on-site
production, it is possible to proceed with the optimal treatment
using a fresh composition not containing any preservatives,
etc.
[0054] Hereinafter, a method for preparing a powder-type
preparation for skin treatment, which is used for preparing the
composition for the treatment described above, is explained in
detail.
[0055] However, it should be noted that the powder-type preparation
explained herein below is one which is independently prepared by a
supplier and distributed to users, unlike the composition described
above which is directly prepared by a user before performing the
treatment.
[0056] As described above, these powder-type preparations are
constituted to include any one among hyaluronic acid, vitamin C,
retinol, tranexamic acid, and ceramide as an active ingredient.
Herein below, each of the preparation methods for the powder-type
preparations containing hyaluronic acid as an active ingredient is
explained.
[0057] Methods of Preparing Powder-Type Preparations Containing
Hyaluronic Acid
[0058] First, a step of preparing a liquid material, which includes
an ingredient material contained in the powder-type preparation, is
included (S110). The liquid material may be constituted to include
an ingredient material for skin treatment, which includes glycerin
in a monoolein-melt solution, so as to form a cubosome structure
being made of glyceryl monooleate (GMO). The step may consist of a
step of preparing an oil phase solution and a step of preparing a
water phase solution.
[0059] In particular, with respect to the step of preparing an oil
phase solution, d-panthenol and squalane are added to monoolein,
which is in a state melted in a water bath at room temperature or
higher, and the mixture is stirred using a stirrer and thereby an
oil phase solution can be prepared.
[0060] In particular, monoolein is a material which forms a cubic
phase when it establishes an equilibration with an adequate or
higher amount of water and it can form a structural backbone. The
cubic phase formed by monoolein is optically transparent and has
water channels that traverse between them. The cubic phase has a
water channel in a lipid matrix and thus it can load a
water-soluble compound in the water channel while loading a
lipid-soluble compound in the lipid matrix and thus can be used as
a drug carrier.
[0061] Additionally, d-panthenol is a material which has the
effects of promoting cell growth, moisturization, and wound
healing, and squalene is a natural fat component which can supply
oil fractions that smoothen skin.
[0062] Meanwhile, the step of preparing a water phase solution may
be proceeded by heating a mixture of distilled water, glycerin, and
a surfactant, which are contained in a separate container apart
from that for the oil phase solution, at room temperature or
higher. In particular, poloxamer P407 may be used as the
surfactant.
[0063] Once a liquid material is prepared through the process
described above, a step of preparing a dispersion may be performed
using the material (S120). In this step, an oil phase solution is
added to the water phase solution prepared in the above step and
blend them using a stirrer to produce a mixed solution. In the
mixed solution, a process that the oil phase particles of the oil
phase solution are fractionated by a surfactant is performed.
[0064] In this embodiment, a dispersion including nano-sized liquid
crystal particles can be prepared by fractionating the oil phase
particles to a nano size by additionally providing sonication to
such a mixed solution. For example, in an embodiment, a dispersion
including nano-sized particles was prepared by providing sonication
having a frequency in a range of 10 to 100 KHz for 30 minutes.
[0065] Then, a step of preparing an excipient is performed apart
from the dispersion (S130). In particular, the excipient may be
constituted to include non-essential amino acids, and in this
embodiment, the preparation of the excipient may be performed in
such a manner that glycine, proline, Na.sub.2HPO.sub.4.7H.sub.2O,
KH.sub.2PO.sub.4, and hyaluronic acid are mixed in a predetermined
amount. However, the ingredients that constitute the excipient may
be constituted by adding other ingredient(s) in consideration of
therapeutic effects.
[0066] Once the dispersion and excipient are prepared by the steps
described above, a step of granulating a powder-type preparation
can be performed using the same (S140). The step of granulating of
a powder-type preparation may be performed using a fluidized-bed
granulator. The granulation process may be performed in a state
where the excipient is injected into the fluidized-bed granulator
by spraying the prepared dispersion. In particular, the granulation
serves the role of a binder and thereby the granulation of the
dispersion and excipient can be proceeded, and drying is proceeded
simultaneously during the granulation process and thereby a
powder-type preparation is prepared.
[0067] The powder-type preparation containing hyaluronic acid
prepared by the above process can deliver hyaluronic acid to skin
tissue and provide an environment where moisture can be retained in
the dermis thereby being capable of maintaining moist and healthy
skin, and in particular, being capable of sustaining the skin
structure thereby exhibiting an effect of preventing skin
wrinkles.
[0068] Method of Preparing a Powder-Type Preparation Containing
Tranexamic Acid
[0069] The method of preparing a powder-type preparation containing
tranexamic acid is proceeded in a manner similar to that of
preparing a powder-type preparation containing hyaluronic acid
described above.
[0070] However, in the step of preparing a water phase solution
during the step of preparing a liquid phase material, the step is
proceeded in such a manner that a mixture, which is in a state
further mixed with tranexamic acid, in addition to distilled water,
glycerin, and a surfactant, is heated to a room temperature or
higher.
[0071] Additionally, in the step of preparing an excipient, the
preparation is proceeded in such a manner that not only glycine,
proline, Na.sub.2HPO.sub.4.7H.sub.2O, KH.sub.2PO.sub.4, and
hyaluronic acid but tranexamic acid is mixed in a predetermined
amount.
[0072] Additionally, a powder-type preparation containing
tranexamic acid can be prepared through the step of granulating a
powder-type preparation using the dispersion and excipient prepared
by the same.
[0073] The thus-prepared powder-type preparation containing
tranexamic acid can deliver tranexamic acid to skin tissue and the
delivered tranexamic acid acts on melanocytes within tissues to
inhibit the biosynthesis of melanin thereby preventing the
generation of melasma or black spot on skin and exhibiting the
effect of skin whitening.
[0074] Method of Preparing a Powder-Type Preparation Containing
Retinol--Vitamin A
[0075] The method of preparing a powder-type preparation containing
vitamin A is proceeded in a manner similar to that of preparing a
powder-type preparation containing hyaluronic acid described
above.
[0076] However, in the step of preparing an oil phase solution
during the step of preparing a liquid phase material, the oil phase
solution can be prepared in such a manner that not only d-panthenol
and squalene but also vitamin A material is added in a state where
monoolein is melted by stirring using a stirrer.
[0077] Additionally, a powder-type preparation containing vitamin A
can be prepared through a step of granulating the powder-type
preparation using a dispersion prepared by the same.
[0078] The thus-prepared powder-type preparation containing vitamin
A can deliver vitamin A to skin tissue and the delivered vitamin A
can inhibit overproliferation of sebaceous gland within the tissue
thereby reducing the amount of sebum secretion, normalizing the
desquamation process within the tissue thereby exhibiting effects
of treating acne and inhibiting wrinkle formation on skin.
[0079] Method of Preparing a Powder-Type Preparation Containing
Vitamin C
[0080] The method of preparing a powder-type preparation containing
vitamin C is proceeded in a manner similar to that of preparing a
powder-type preparation containing hyaluronic acid described
above.
[0081] However, in the step of preparing a water phase solution
during the step of preparing a liquid phase material, the step is
proceeded in such a manner that a mixture, which is in a state
further mixed with ascorbic acid, in addition to distilled water,
glycerin, and a surfactant, is heated to a room temperature or
higher.
[0082] Additionally, in the step of preparing an excipient, the
preparation is proceeded in such a manner that not only glycine,
proline, Na.sub.2HPO.sub.4.7H.sub.2O, KH.sub.2PO.sub.4, and
hyaluronic acid but also ascorbic acid is mixed in a predetermined
amount.
[0083] Additionally, a powder-type preparation containing ascorbic
acid can be prepared through the step of granulating a powder-type
preparation using the dispersion and excipient prepared by the
same.
[0084] The thus-prepared powder-type preparation containing vitamin
C can deliver vitamin C, which is essential for cell growth and
damage recovery, to skin tissue and the delivered vitamin C can
inhibit the aging of skin tissue, promote collagen synthesis within
the tissue, growth, differentiation, and regeneration of skin
tissue, and inhibit pigmentation such as melasma, etc., thereby
exhibiting the effect of skin whitening.
[0085] Method of Preparing a Powder-Type Preparation Containing
Ceramide
[0086] The method of preparing a powder-type preparation containing
ceramide is proceeded in a manner similar to that of preparing a
powder-type preparation containing hyaluronic acid described
above.
[0087] However, in the step of preparing an oil phase solution
during the step of preparing a liquid phase material, the oil phase
solution can be prepared in such a manner that not only d-panthenol
and squalene but also ceramide is added in a state where monoolein
is melted by stirring using a stirrer.
[0088] Additionally, a powder-type preparation containing ceramide
can be prepared through the step of granulating a powder-type
preparation using the dispersion prepared by the same.
[0089] The thus-prepared powder-type preparation containing
ceramide can deliver ceramide, which constitutes the lipid
component of skin, to skin tissue and the delivered ceramide can
inhibit the evaporation of moisture in tissue thereby exhibiting
the effects of maintaining the skin moist and preventing the
occurrence of atopic dermatitis.
[0090] Although preferred embodiments of the present invention have
been described above for illustrative purposes, the scope of the
present invention should not be limited by the specific embodiments
provided above. It would be obvious to one of ordinary skill in the
art that various modifications and changes are possible, without
departing from the scope and spirit of the invention as disclosed
in the accompanying claims.
* * * * *