U.S. patent application number 15/466587 was filed with the patent office on 2017-07-27 for monospecific and multispecific antibodies and method of use. The applicant listed for this patent is BAYER INTELLECTUAL PROPERTY GMBH. Invention is credited to David LIGHT, Bing LIU, Douglas SCHNEIDER, Zhuozhi WANG.
Application Number | 20170210825 15/466587 |
Document ID | / |
Family ID | 40110987 |
Filed Date | 2017-07-27 |
United States Patent Application | 20170210825 |
Kind Code | A1 |
LIU; Bing ; et al. | July 27, 2017 |
This invention relates to monospecific and multispecific antibodies that may be utilized for the diagnosis and treatment of various diseases. In addition, these antibodies may be modified by protease cleavage. Protease control or regulation may be provided by a protease site located in, for example, a linker. These protease-regulated antibodies may also be utilized for the diagnosis and treatment of various diseases.
Inventors: | LIU; Bing; (Richmond, CA) ; LIGHT; David; (San Mateo, CA) ; WANG; Zhuozhi; (Burlingame, CA) ; SCHNEIDER; Douglas; (Lafayette, CA) | ||||||||||
Applicant: |
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Family ID: | 40110987 | ||||||||||
Appl. No.: | 15/466587 | ||||||||||
Filed: | March 22, 2017 |
Application Number | Filing Date | Patent Number | ||
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12671942 | Feb 22, 2010 | 9624309 | ||
PCT/EP08/06750 | Aug 16, 2008 | |||
15466587 | ||||
60955913 | Aug 15, 2007 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | A61K 39/39558 20130101; A61K 47/6803 20170801; A61P 17/00 20180101; C07K 16/3076 20130101; C07K 16/3069 20130101; A61P 5/14 20180101; A61P 7/06 20180101; A61P 37/02 20180101; A61K 47/6851 20170801; A61K 47/6809 20170801; A61P 31/20 20180101; C07K 2317/31 20130101; Y02A 50/412 20180101; C07K 16/36 20130101; A61P 1/16 20180101; A61K 45/06 20130101; A61P 29/00 20180101; C07K 16/468 20130101; A61K 47/6821 20170801; A61P 17/06 20180101; A61P 9/00 20180101; A61K 39/3955 20130101; C07K 2317/56 20130101; A61K 47/6827 20170801; A61P 31/00 20180101; A61P 35/02 20180101; A61P 1/12 20180101; A61K 47/6829 20170801; A61P 33/06 20180101; A61P 11/00 20180101; A61P 13/12 20180101; A61P 19/02 20180101; A61P 25/00 20180101; A61P 31/14 20180101; A61P 1/04 20180101; A61K 47/6807 20170801; A61P 3/10 20180101; A61K 2039/505 20130101; A61P 31/06 20180101; C07K 2317/64 20130101; A61K 47/6869 20170801; A61P 35/00 20180101; A61P 31/18 20180101; A61P 31/04 20180101 |
International Class: | C07K 16/46 20060101 C07K016/46; A61K 45/06 20060101 A61K045/06; A61K 39/395 20060101 A61K039/395; C07K 16/36 20060101 C07K016/36; C07K 16/30 20060101 C07K016/30 |
Sequence CWU 1
1
12016PRTArtificial SequenceLinker 1 1Ser Asp Asp Asp Asp Lys 1 5
210PRTArtificial SequenceLinker 2 2Gly Gly Gly Gly Ser Asp Asp Asp
Asp Lys 1 5 10 315PRTArtificial SequenceLinker 3 3Gly Gly Gly Gly
Ser Asp Asp Asp Asp Lys Gly Gly Gly Gly Ser 1 5 10 15
415PRTArtificial SequenceLinker 4 4Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser 1 5 10 15 520PRTArtificial
SequenceLinker 5 5Ile His Pro Val Leu Ser Gly Leu Ser Arg Ile Val
Asn Gly Glu Asp 1 5 10 15 Ala Val Pro Gly 20 620PRTArtificial
SequenceLinker 6 6Val Ala Ala Pro Phe Asp Asp Asp Asp Lys Ile Val
Gly Gly Tyr Ile 1 5 10 15 Cys Glu Glu Asn 20 720PRTArtificial
SequenceLinker 7 7Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val
Glu Gly Ser Asp 1 5 10 15 Ala Glu Ile Gly 20 820PRTArtificial
SequenceLinker 8 8Ser Thr Gln Ser Phe Asn Asp Phe Thr Arg Val Val
Gly Gly Glu Asp 1 5 10 15 Ala Lys Pro Gly 20 920PRTArtificial
SequenceLinker 9 9Pro Glu Arg Gly Asp Asn Asn Leu Thr Arg Ile Val
Gly Gly Gln Glu 1 5 10 15 Cys Lys Asp Gly 20 1020PRTArtificial
SequenceLinker 10 10Glu Asp Gln Glu Asp Gln Val Asp Pro Arg Leu Ile
Asp Gly Lys Met 1 5 10 15 Thr Arg Arg Gly 20 1120PRTArtificial
SequenceLinker 11 11Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val
Gly Gly Lys Val 1 5 10 15 Cys Pro Lys Gly 20 1220PRTArtificial
SequenceLinker 12 12Ser Val Cys Thr Thr Lys Thr Ser Thr Arg Ile Val
Gly Gly Thr Asn 1 5 10 15 Ser Ser Trp Gly 20 135PRTArtificial
SequenceLinker 13 13Ser Arg Ile Val Gly 1 5 1420PRTArtificial
SequenceLinker 14 14Gly Ser Leu Val Ser Gly Ser Cys Ser Gln Ile Ile
Asn Gly Glu Asp 1 5 10 15 Cys Ser Pro His 20 155PRTArtificial
SequenceLinker 15 15Ser Arg Ile Ile Asn 1 5 165PRTArtificial
SequenceLinker 16 16Asn Lys Leu Val His 1 5 175PRTArtificial
SequenceLinker 17 17Asp Lys Ile Ile Asp 1 5 185PRTArtificial
SequenceLinker 18 18Phe Asn Val Leu Gly 1 5 195PRTArtificial
SequenceLinker 19 19Thr Arg Ala Ile Gly 1 5 205PRTArtificial
SequenceLinker 20 20Thr Arg Leu Asp Pro 1 5 215PRTArtificial
SequenceLinker 21 21Thr Arg Ile Ile Lys 1 5 225PRTArtificial
SequenceLinker 22 22Ser Gly Ser Asn Gln 1 5 235PRTArtificial
SequenceLinker 23 23Ser Lys Val Leu Asn 1 5 245PRTArtificial
SequenceLinker 24 24Asn Lys Ile Ile Gly 1 5 255PRTArtificial
SequenceLinker 25 25Asp Lys Leu Leu Glu 1 5 265PRTArtificial
SequenceLinker cleavage site 26Asp Asp Asp Asp Lys 1 5
275PRTArtificial SequenceLinker cleavage site 27Ile Glu Asp Gly Arg
1 5 286PRTArtificial SequenceLinker cleavage site 28Leu Val Pro Arg
Gly Ser 1 5 297PRTArtificial SequenceLinker cleavage site 29Glu Asn
Leu Tyr Phe Gln Gly 1 5 308PRTArtificial SequenceLinkage cleavage
site 30Leu Glu Val Leu Phe Gln Gly Pro 1 5 319PRTArtificial
SequenceLinker cleavage site 31Ser Ser Val Phe Ala Gln Ser Ile Pro
1 5 328PRTArtificial SequenceLinker cleavage site 32Lys Gln Leu Arg
Val Val Asn Gly 1 5 33230PRTArtificial Sequence3E10 Fab-like Light
chain 33Asp Ile Val Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly
Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Val
Ala Ser Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser
Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn His Arg Pro Ser
Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr Ser Ser
Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp
Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn Asn Leu
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 Ala
Gly Gly Gly Gly Ser Asp Asp Asp Asp Lys Arg Thr Val Ala Ala 115 120
125 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
130 135 140 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
Glu Ala 145 150 155 160 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
Ser Gly Asn Ser Gln 165 170 175 Glu Ser Val Thr Glu Gln Asp Ser Lys
Asp Ser Thr Tyr Ser Leu Ser 180 185 190 Ser Thr Leu Thr Leu Ser Lys
Ala Asp Tyr Glu Lys His Lys Val Tyr 195 200 205 Ala Cys Glu Val Thr
His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 210 215 220 Phe Asn Arg
Gly Glu Cys 225 230 34233PRTArtificial Sequence3E10 Fab-like Heavy
chain 34Asp Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly Ser
Leu 1 5 10 15 Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp
Ala Trp Met 20 25 30 Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu
Glu Trp Val Ser Ser 35 40 45 Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Gly Ser Val Lys Gly 50 55 60 Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr Leu Gln 65 70 75 80 Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 85 90 95 Val Leu Ser
Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln
Gly Thr Leu Val Thr Val Ser Ala Ser Asp Asp Asp Asp Lys Ser 115 120
125 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
130 135 140 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp 145 150 155 160 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr 165 170 175 Ser Gly Val His Thr Phe Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr 180 185 190 Ser Leu Ser Ser Val Val Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln 195 200 205 Thr Tyr Ile Cys Asn
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 210 215 220 Lys Lys Val
Glu Pro Lys Cys Glu Phe 225 230 35219PRTArtificial Sequence19G9
Fab-like Light chain 35Asp Ile Val Leu Thr Gln Ser Pro Gly Thr Leu
Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala
Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln
Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser
Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser Leu 85 90
95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Asp Asp Asp Lys
100 105 110 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
Asp Glu 115 120 125 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
Leu Asn Asn Phe 130 135 140 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys
Val Asp Asn Ala Leu Gln 145 150 155 160 Ser Gly Asn Ser Gln Glu Ser
Val Thr Glu Gln Asp Ser Lys Asp Ser 165 170 175 Thr Tyr Ser Leu Ser
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 180 185 190 Lys His Lys
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 195 200 205 Pro
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 36231PRTArtificial
Sequence19G9 Fab-like Heavy chain 36Gln Leu Val Gln Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly Ser Leu 1 5 10 15 Arg Leu Ser Cys Ala Gly
Ser Gly Phe Thr Phe Ser Ser Tyr Val Met 20 25 30 His Trp Leu Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val 35 40 45 Ile Gly
Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys Gly Arg 50 55 60
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 65
70 75 80 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
Arg Trp 85 90 95 Gly Tyr Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala
Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Asp Asp
Asp Asp Lys Ser Ser Ala 115 120 125 Ser Thr Lys Gly Pro Ser Val Phe
Pro Leu Ala Pro Ser Ser Lys Ser 130 135 140 Thr Ser Gly Gly Thr Ala
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 145 150 155 160 Pro Glu Pro
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 165 170 175 Val
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 180 185
190 Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
195 200 205 Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
Lys Lys 210 215 220 Val Glu Pro Lys Cys Glu Phe 225 230
37223PRTArtificial Sequence3E10 IgG-like Light chain 37Asn Phe Met
Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr
Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25
30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val
35 40 45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg
Phe Ser 50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu
Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr
Cys Gln Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly
Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 Gln Ser Asp Asp Asp Asp
Lys Pro Lys Ala Ala Pro Ser Val Thr Leu 115 120 125 Phe Pro Pro Ser
Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 130 135 140 Cys Leu
Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 145 150 155
160 Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser
165 170 175 Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser
Leu Thr 180 185 190 Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys
Gln Val Thr His 195 200 205 Glu Gly Ser Thr Val Glu Lys Thr Val Ala
Pro Thr Glu Cys Ser 210 215 220 38457PRTArtificial Sequence3E10
IgG-like Heavy chain 38Gln Val Asn Leu Arg Glu Ser Gly Gly Thr Leu
Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser
Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val Arg Gln
Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly
Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90
95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp Val
100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ser Asp Asp
Asp Asp 115 120 125 Lys Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Ser Ser Lys Ser 130 135 140 Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe 145 150 155 160 Pro Glu Pro Val Thr Val Ser
Trp Asn Ser Gly Ala Leu Thr Ser Gly 165 170 175 Val His Thr Phe Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 180 185 190 Ser Ser Val
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 195 200 205 Ile
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 210 215
220 Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
225 230 235 240 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
Pro Pro Lys 245 250 255 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val 260 265 270 Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe Asn Trp Tyr 275 280 285 Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg Glu Glu 290 295 300 Gln Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val Leu His 305 310 315 320 Gln Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 325 330 335
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 340
345 350 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
Met 355 360 365 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
Phe Tyr Pro 370 375 380 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn 385 390 395 400 Tyr Lys Thr Thr Pro Pro Val Leu
Asp Ser Asp Gly Ser Phe Phe Leu 405 410 415 Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 420 425 430 Phe Ser Cys Ser
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 435 440 445 Lys Ser
Leu Ser Leu Ser Pro Gly Lys 450 455 39220PRTArtificial Sequence19G9
IgG-like Light chain 39Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu
Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala
Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln
Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser
Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser Leu 85 90
95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Ser Asp Asp
100 105 110 Asp Asp Lys Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
Ser Asp 115 120 125 Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys
Leu Leu Asn Asn 130 135 140 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp
Lys Val Asp Asn Ala Leu 145 150 155
160 Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
165 170 175 Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
Asp Tyr 180 185 190 Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
Gln Gly Leu Ser 195 200 205 Ser Pro Val Thr Lys Ser Phe Asn Arg Gly
Glu Cys 210 215 220 40460PRTArtificial Sequence19G9 IgG-like Heavy
chain 40Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly
Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe
Ser Ser Tyr 20 25 30 Val Met His Trp Leu Arg Gln Ala Pro Gly Lys
Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Gly Thr Gly Gly Val Thr
His Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg
Asp Asn Ala Lys Asn Ser Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Trp Gly
Tyr Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala Phe Asp 100 105 110 Ile
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Asp Asp 115 120
125 Asp Asp Asp Lys Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser
130 135 140 Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
Val Lys 145 150 155 160 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
Asn Ser Gly Ala Leu 165 170 175 Thr Ser Gly Val His Thr Phe Pro Ala
Val Leu Gln Ser Ser Gly Leu 180 185 190 Tyr Ser Leu Ser Ser Val Val
Thr Val Pro Ser Ser Ser Leu Gly Thr 195 200 205 Gln Thr Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 210 215 220 Asp Lys Arg
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 225 230 235 240
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 245
250 255 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
Val 260 265 270 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
Val Lys Phe 275 280 285 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
Ala Lys Thr Lys Pro 290 295 300 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
Arg Val Val Ser Val Leu Thr 305 310 315 320 Val Leu His Gln Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 325 330 335 Ser Asn Lys Ala
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 340 345 350 Lys Gly
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 355 360 365
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 370
375 380 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
Pro 385 390 395 400 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly Ser 405 410 415 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
Lys Ser Arg Trp Gln Gln 420 425 430 Gly Asn Val Phe Ser Cys Ser Val
Met His Glu Ala Leu His Asn His 435 440 445 Tyr Thr Gln Lys Ser Leu
Ser Leu Ser Pro Gly Lys 450 455 460 41333PRTArtificial SequenceH1L1
Light chain 41Asp Ile Val Leu Thr Gln Pro His Ser Val Ser Ala Ser
Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly
Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro
Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn His Arg
Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr
Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr
Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn
Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105
110 Ala Ser Asp Asp Asp Asp Lys Glu Ile Val Leu Thr Gln Ser Pro Gly
115 120 125 Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys
Arg Ala 130 135 140 Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr
Gln Gln Lys Pro 145 150 155 160 Gly Gln Ala Pro Arg Leu Leu Ile Tyr
Gly Ala Ser Ser Arg Ala Thr 165 170 175 Gly Ile Pro Asp Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr 180 185 190 Leu Thr Ile Ser Arg
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 195 200 205 Gln Gln Tyr
Ser Ser Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 210 215 220 Ile
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 225 230
235 240 Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
Asn 245 250 255 Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val
Asp Asn Ala 260 265 270 Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr
Glu Gln Asp Ser Lys 275 280 285 Asp Ser Thr Tyr Ser Leu Ser Ser Thr
Leu Thr Leu Ser Lys Ala Asp 290 295 300 Tyr Glu Lys His Lys Val Tyr
Ala Cys Glu Val Thr His Gln Gly Leu 305 310 315 320 Ser Ser Pro Val
Thr Lys Ser Phe Asn Arg Gly Glu Cys 325 330 42357PRTArtificial
SequenceH1L1 Heavy chain 42Gln Val Gln Leu Val Glu Ser Gly Gly Thr
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp
Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ser Asp
Asp Asp Asp 115 120 125 Lys Glu Val Gln Leu Val Gln Ser Gly Gly Gly
Leu Val Gln Pro Gly 130 135 140 Gly Ser Leu Arg Leu Ser Cys Ala Gly
Ser Gly Phe Thr Phe Ser Ser 145 150 155 160 Tyr Val Met His Trp Leu
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 165 170 175 Val Ser Val Ile
Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val 180 185 190 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 195 200 205
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 210
215 220 Ala Arg Trp Gly Tyr Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala
Phe 225 230 235 240 Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser
Ser Ala Ser Thr 245 250 255 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Ser Ser Lys Ser Thr Ser 260 265 270 Gly Gly Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro Glu 275 280 285 Pro Val Thr Val Ser Trp
Asn Ser Gly Ala Leu Thr Ser Gly Val His 290 295 300 Thr Phe Pro Ala
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 305 310 315 320 Val
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 325 330
335 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
340 345 350 Pro Lys Cys Glu Phe 355 43330PRTArtificial SequenceH1L4
Light chain 43Asp Ile Val Leu Thr Gln Pro His Ser Val Ser Ala Ser
Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly
Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro
Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn His Arg
Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr
Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr
Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn
Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105
110 Ala Ser Asp Asp Asp Asp Lys Leu Thr Gln Ser Pro Gly Thr Leu Ser
115 120 125 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser
Gln Ser 130 135 140 Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys
Pro Gly Gln Ala 145 150 155 160 Pro Arg Leu Leu Ile Tyr Gly Ala Ser
Ser Arg Ala Thr Gly Ile Pro 165 170 175 Asp Arg Phe Ser Gly Ser Gly
Ser Gly Thr Asp Phe Thr Leu Thr Ile 180 185 190 Ser Arg Leu Glu Pro
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 195 200 205 Ser Ser Ser
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 210 215 220 Thr
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 225 230
235 240 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
Tyr 245 250 255 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
Leu Gln Ser 260 265 270 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp
Ser Lys Asp Ser Thr 275 280 285 Tyr Ser Leu Ser Ser Thr Leu Thr Leu
Ser Lys Ala Asp Tyr Glu Lys 290 295 300 His Lys Val Tyr Ala Cys Glu
Val Thr His Gln Gly Leu Ser Ser Pro 305 310 315 320 Val Thr Lys Ser
Phe Asn Arg Gly Glu Cys 325 330 44357PRTArtificial SequenceH1L4
Heavy chain 44Gln Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly
Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Val Leu Ser Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105
110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ser Asp Asp Asp Asp
115 120 125 Lys Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln
Pro Gly 130 135 140 Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe
Thr Phe Ser Ser 145 150 155 160 Tyr Val Met His Trp Leu Arg Gln Ala
Pro Gly Lys Gly Leu Glu Trp 165 170 175 Val Ser Val Ile Gly Thr Gly
Gly Val Thr His Tyr Ala Asp Ser Val 180 185 190 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 195 200 205 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 210 215 220 Ala
Arg Trp Gly Tyr Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala Phe 225 230
235 240 Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser
Thr 245 250 255 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
Ser Thr Ser 260 265 270 Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
Asp Tyr Phe Pro Glu 275 280 285 Pro Val Thr Val Ser Trp Asn Ser Gly
Ala Leu Thr Ser Gly Val His 290 295 300 Thr Phe Pro Ala Val Leu Gln
Ser Ser Gly Leu Tyr Ser Leu Ser Ser 305 310 315 320 Val Val Thr Val
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 325 330 335 Asn Val
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 340 345 350
Pro Lys Cys Glu Phe 355 45327PRTArtificial SequenceH1L7 Light chain
45Asp Ile Val Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1
5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser
Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro
Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val
Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser
Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala
Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 Ala Ser Asp
Asp Asp Asp Lys Ser Pro Gly Thr Leu Ser Leu Ser Pro 115 120 125 Gly
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 130 135
140 Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu
145 150 155 160 Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro
Asp Arg Phe 165 170 175 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser Arg Leu 180 185 190 Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln Gln Tyr Ser Ser Ser 195 200 205 Leu Thr Phe Gly Gly Gly Thr
Lys Val Glu Ile Lys Arg Thr Val Ala 210 215 220 Ala Pro Ser Val Phe
Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 225 230 235 240 Gly Thr
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 245 250 255
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 260
265 270 Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
Leu 275 280 285 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
His Lys Val 290 295 300 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
Ser Pro Val Thr Lys 305 310 315 320 Ser Phe Asn Arg Gly Glu Cys 325
46357PRTArtificial SequenceH1L7 Heavy chain 46Gln Val Gln Leu Val
Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp
Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala
Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr
Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr
Leu Val Thr Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys Glu Val
Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly 130 135 140 Gly
Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser 145 150
155 160 Tyr Val Met His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu
Trp 165 170 175 Val Ser Val Ile Gly Thr Gly Gly Val Thr His Tyr Ala
Asp Ser Val 180 185 190 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
Lys Asn Ser Leu Tyr 195 200 205 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 210 215 220 Ala Arg Trp Gly Tyr Tyr Gly
Ser Gly Ser Tyr Glu Asn Asp Ala Phe 225 230 235 240 Asp Ile Trp Gly
Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr 245 250 255 Lys Gly
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 260 265 270
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 275
280 285 Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
His 290 295 300 Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
Leu Ser Ser 305 310 315 320 Val Val Thr Val Pro Ser Ser Ser Leu Gly
Thr Gln Thr Tyr Ile Cys 325 330 335 Asn Val Asn His Lys Pro Ser Asn
Thr Lys Val Asp Lys Lys Val Glu 340 345 350 Pro Lys Cys Glu Phe 355
47331PRTArtificial SequenceH4L2 Light chain 47Asp Ile Val Leu Thr
Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr
Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr
Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40
45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile
Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln
Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly 100 105 110 Asp Asp Asp Asp Lys Glu Ile Val
Leu Thr Gln Ser Pro Gly Thr Leu 115 120 125 Ser Leu Ser Pro Gly Glu
Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 130 135 140 Ser Val Ser Ser
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 145 150 155 160 Ala
Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 165 170
175 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
180 185 190 Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
Gln Gln 195 200 205 Tyr Ser Ser Ser Leu Thr Phe Gly Gly Gly Thr Lys
Val Glu Ile Lys 210 215 220 Arg Thr Val Ala Ala Pro Ser Val Phe Ile
Phe Pro Pro Ser Asp Glu 225 230 235 240 Gln Leu Lys Ser Gly Thr Ala
Ser Val Val Cys Leu Leu Asn Asn Phe 245 250 255 Tyr Pro Arg Glu Ala
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 260 265 270 Ser Gly Asn
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 275 280 285 Thr
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 290 295
300 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
305 310 315 320 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 325 330
48349PRTArtificial SequenceH4L2 Heavy chain 48Gln Val Gln Leu Val
Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40
45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val
50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr
Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr
Val Asp Asp Asp Asp Lys Gln Ser 115 120 125 Gly Gly Gly Leu Val Gln
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 130 135 140 Gly Ser Gly Phe
Thr Phe Ser Ser Tyr Val Met His Trp Leu Arg Gln 145 150 155 160 Ala
Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Gly Thr Gly Gly 165 170
175 Val Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg
180 185 190 Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu
Arg Ala 195 200 205 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly
Tyr Tyr Gly Ser 210 215 220 Gly Ser Tyr Glu Asn Asp Ala Phe Asp Ile
Trp Gly Gln Gly Thr Met 225 230 235 240 Val Thr Val Ser Ser Ala Ser
Thr Lys Gly Pro Ser Val Phe Pro Leu 245 250 255 Ala Pro Ser Ser Lys
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 260 265 270 Leu Val Lys
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 275 280 285 Gly
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 290 295
300 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
305 310 315 320 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
Pro Ser Asn 325 330 335 Thr Lys Val Asp Lys Lys Val Glu Pro Lys Cys
Glu Phe 340 345 49328PRTArtificial SequenceH4L5 Light chain 49Asp
Ile Val Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10
15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr
20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr
Thr Val 35 40 45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro
Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala
Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp
Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe
Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 Asp Asp Asp Asp
Lys Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 115 120 125 Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 130 135 140
Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 145
150 155 160 Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro
Asp Arg 165 170 175 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser Arg 180 185 190 Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln Gln Tyr Ser Ser 195 200 205 Ser Leu Thr Phe Gly Gly Gly Thr
Lys Val Glu Ile Lys Arg Thr Val 210 215 220 Ala Ala Pro Ser Val Phe
Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 225 230 235 240 Ser Gly Thr
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 245 250 255 Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 260 265
270 Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
275 280 285 Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
His Lys 290 295 300 Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
Ser Pro Val Thr 305 310 315 320 Lys Ser Phe Asn Arg Gly Glu Cys 325
50349PRTArtificial SequenceH4L5 Heavy chain 50Gln Val Gln Leu Val
Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40
45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val
50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr
Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr
Val Asp Asp Asp Asp Lys Gln Ser 115 120 125 Gly Gly Gly Leu Val Gln
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 130 135 140 Gly Ser Gly Phe
Thr Phe Ser Ser Tyr Val Met His Trp Leu Arg Gln 145 150 155 160 Ala
Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Gly Thr Gly Gly 165 170
175 Val Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg
180 185 190 Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu
Arg Ala 195 200 205 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly
Tyr Tyr Gly Ser 210 215 220 Gly Ser Tyr Glu Asn Asp Ala Phe Asp Ile
Trp Gly Gln Gly Thr Met 225 230 235 240 Val Thr Val Ser Ser Ala Ser
Thr Lys Gly Pro Ser Val Phe Pro Leu 245 250 255 Ala Pro Ser Ser Lys
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 260 265 270 Leu Val Lys
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 275 280 285 Gly
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 290 295
300 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
305 310 315 320 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
Pro Ser Asn 325 330 335 Thr Lys Val Asp Lys Lys Val Glu Pro Lys Cys
Glu Phe 340 345 51327PRTArtificial SequenceH4L7 51Asp Ile Val Leu
Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val
Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35
40 45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe
Ser 50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr
Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys
Gln Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly Gly
Thr Lys Leu Thr Val Leu Gly 100 105 110 Ala Ser Asp Asp Asp Asp Lys
Ser Pro Gly Thr Leu Ser Leu Ser Pro 115 120 125 Gly Glu Arg Ala Thr
Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 130 135 140 Ser Tyr Leu
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 145 150 155 160
Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 165
170 175 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg
Leu 180 185 190 Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr
Ser Ser Ser 195 200 205 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
Lys Arg Thr Val Ala 210 215 220 Ala Pro Ser Val Phe Ile Phe Pro Pro
Ser Asp Glu Gln Leu Lys Ser 225 230 235 240 Gly Thr Ala Ser Val Val
Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 245 250 255 Ala Lys Val Gln
Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 260 265 270 Gln Glu
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 275 280 285
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 290
295 300 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
Lys 305 310 315 320 Ser Phe Asn Arg Gly Glu Cys 325
52349PRTArtificial SequenceH4L7 Heavy chain 52Gln Val Gln Leu Val
Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40
45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val
50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr
Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr
Val Asp Asp Asp Asp Lys Gln Ser 115 120 125 Gly Gly Gly Leu Val Gln
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 130 135 140 Gly Ser Gly Phe
Thr Phe Ser Ser Tyr Val Met His Trp Leu Arg Gln 145 150 155 160 Ala
Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Gly Thr Gly Gly 165 170
175 Val Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg
180 185 190 Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu
Arg Ala 195 200 205 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly
Tyr Tyr Gly Ser 210 215 220 Gly Ser Tyr Glu Asn Asp Ala Phe Asp Ile
Trp Gly Gln Gly Thr Met 225 230 235 240 Val Thr Val Ser Ser Ala Ser
Thr Lys Gly Pro Ser Val Phe Pro Leu 245 250 255 Ala Pro Ser Ser Lys
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 260 265
270 Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
275 280 285 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
Gln Ser 290 295 300 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
Pro Ser Ser Ser 305 310 315 320 Leu Gly Thr Gln Thr Tyr Ile Cys Asn
Val Asn His Lys Pro Ser Asn 325 330 335 Thr Lys Val Asp Lys Lys Val
Glu Pro Lys Cys Glu Phe 340 345 53328PRTArtificial SequenceH5L5
Light chain 53Asp Ile Val Leu Thr Gln Pro His Ser Val Ser Ala Ser
Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly
Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro
Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn His Arg
Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr
Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr
Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn
Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105
110 Asp Asp Asp Asp Lys Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser
115 120 125 Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser
Val Ser 130 135 140 Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly
Gln Ala Pro Arg 145 150 155 160 Leu Leu Ile Tyr Gly Ala Ser Ser Arg
Ala Thr Gly Ile Pro Asp Arg 165 170 175 Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser Arg 180 185 190 Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser 195 200 205 Ser Leu Thr
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 210 215 220 Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 225 230
235 240 Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro
Arg 245 250 255 Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
Ser Gly Asn 260 265 270 Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys
Asp Ser Thr Tyr Ser 275 280 285 Leu Ser Ser Thr Leu Thr Leu Ser Lys
Ala Asp Tyr Glu Lys His Lys 290 295 300 Val Tyr Ala Cys Glu Val Thr
His Gln Gly Leu Ser Ser Pro Val Thr 305 310 315 320 Lys Ser Phe Asn
Arg Gly Glu Cys 325 54347PRTArtificial SequenceH5L5 Heavy chain
54Gln Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1
5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp
Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu
Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser
Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln
Gly Thr Leu Val Thr Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser 130 135
140 Gly Phe Thr Phe Ser Ser Tyr Val Met His Trp Leu Arg Gln Ala Pro
145 150 155 160 Gly Lys Gly Leu Glu Trp Val Ser Val Ile Gly Thr Gly
Gly Val Thr 165 170 175 His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn 180 185 190 Ala Lys Asn Ser Leu Tyr Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp 195 200 205 Thr Ala Val Tyr Tyr Cys Ala
Arg Trp Gly Tyr Tyr Gly Ser Gly Ser 210 215 220 Tyr Glu Asn Asp Ala
Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr 225 230 235 240 Val Ser
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 245 250 255
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 260
265 270 Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
Ala 275 280 285 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
Ser Ser Gly 290 295 300 Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
Ser Ser Ser Leu Gly 305 310 315 320 Thr Gln Thr Tyr Ile Cys Asn Val
Asn His Lys Pro Ser Asn Thr Lys 325 330 335 Val Asp Lys Lys Val Glu
Pro Lys Cys Glu Phe 340 345 55333PRTArtificial
Sequence3E10-Linker1-19G9 Light chain 55Asn Phe Met Leu Thr Gln Pro
His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser
Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln
Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile
Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55
60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr
Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu
Thr Val Leu Gly 100 105 110 Ala Ser Asp Asp Asp Asp Lys Glu Ile Val
Leu Thr Gln Ser Pro Gly 115 120 125 Thr Leu Ser Leu Ser Pro Gly Glu
Arg Ala Thr Leu Ser Cys Arg Ala 130 135 140 Ser Gln Ser Val Ser Ser
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 145 150 155 160 Gly Gln Ala
Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 165 170 175 Gly
Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 180 185
190 Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
195 200 205 Gln Gln Tyr Ser Ser Ser Leu Thr Phe Gly Gly Gly Thr Lys
Val Glu 210 215 220 Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile
Phe Pro Pro Ser 225 230 235 240 Asp Glu Gln Leu Lys Ser Gly Thr Ala
Ser Val Val Cys Leu Leu Asn 245 250 255 Asn Phe Tyr Pro Arg Glu Ala
Lys Val Gln Trp Lys Val Asp Asn Ala 260 265 270 Leu Gln Ser Gly Asn
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 275 280 285 Asp Ser Thr
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 290 295 300 Tyr
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 305 310
315 320 Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 325 330
56583PRTArtificial Sequence3E10-Linker1-19G9 Heavy chain 56Gln Val
Asn Leu Arg Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20
25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp
Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala
Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr
Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr
Leu Val Thr Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys Glu Val
Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly 130 135 140 Gly
Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser 145 150
155 160 Tyr Val Met His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu
Trp 165 170 175 Val Ser Val Ile Gly Thr Gly Gly Val Thr His Tyr Ala
Asp Ser Val 180 185 190 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
Lys Asn Ser Leu Tyr 195 200 205 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 210 215 220 Ala Arg Trp Gly Tyr Tyr Gly
Ser Gly Ser Tyr Glu Asn Asp Ala Phe 225 230 235 240 Asp Ile Trp Gly
Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr 245 250 255 Lys Gly
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 260 265 270
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 275
280 285 Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
His 290 295 300 Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
Leu Ser Ser 305 310 315 320 Val Val Thr Val Pro Ser Ser Ser Leu Gly
Thr Gln Thr Tyr Ile Cys 325 330 335 Asn Val Asn His Lys Pro Ser Asn
Thr Lys Val Asp Lys Arg Val Glu 340 345 350 Pro Lys Ser Cys Asp Lys
Thr His Thr Cys Pro Pro Cys Pro Ala Pro 355 360 365 Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 370 375 380 Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 385 390 395
400 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
405 410 415 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Tyr 420 425 430 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
Leu His Gln Asp 435 440 445 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys Ala Leu 450 455 460 Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly Gln Pro Arg 465 470 475 480 Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 485 490 495 Asn Gln Val
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 500 505 510 Ile
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 515 520
525 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
530 535 540 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser 545 550 555 560 Cys Ser Val Met His Glu Ala Leu His Asn His
Tyr Thr Gln Lys Ser 565 570 575 Leu Ser Leu Ser Pro Gly Lys 580
57337PRTArtificial Sequence3E10-Linker2-19G9 Light chain 57Asn Phe
Met Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20
25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr
Val 35 40 45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp
Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser
Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr
Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly
Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 Ala Gly Gly Gly Gly
Ser Asp Asp Asp Asp Lys Glu Ile Val Leu Thr 115 120 125 Gln Ser Pro
Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 130 135 140 Ser
Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr 145 150
155 160 Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala
Ser 165 170 175 Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser
Gly Ser Gly 180 185 190 Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
Pro Glu Asp Phe Ala 195 200 205 Val Tyr Tyr Cys Gln Gln Tyr Ser Ser
Ser Leu Thr Phe Gly Gly Gly 210 215 220 Thr Lys Val Glu Ile Lys Arg
Thr Val Ala Ala Pro Ser Val Phe Ile 225 230 235 240 Phe Pro Pro Ser
Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 245 250 255 Cys Leu
Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 260 265 270
Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 275
280 285 Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr
Leu 290 295 300 Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys
Glu Val Thr 305 310 315 320 His Gln Gly Leu Ser Ser Pro Val Thr Lys
Ser Phe Asn Arg Gly Glu 325 330 335 Cys 58587PRTArtificial
Sequence3E10-Linker2-19G9 Heavy chain 58Gln Val Asn Leu Arg Glu Ser
Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser
Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser
Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser
Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55
60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr Trp Tyr
Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ala Gly Gly Gly Gly Ser 115 120 125 Asp Asp Asp Asp Lys Glu Val Gln
Leu Val Gln Ser Gly Gly Gly Leu 130 135 140 Val Gln Pro Gly Gly Ser
Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe 145 150 155 160 Thr Phe Ser
Ser Tyr Val Met His Trp Leu Arg Gln Ala Pro Gly Lys 165 170 175 Gly
Leu Glu Trp Val Ser Val Ile Gly Thr Gly Gly Val Thr His Tyr 180 185
190 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys
195 200 205 Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala 210 215 220 Val Tyr Tyr Cys Ala Arg Trp Gly Tyr Tyr Gly Ser
Gly Ser Tyr Glu 225 230 235 240 Asn Asp Ala Phe Asp Ile Trp Gly Gln
Gly Thr Met Val Thr Val Ser 245
250 255 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser
Ser 260 265 270 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
Val Lys Asp 275 280 285 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr 290 295 300 Ser Gly Val His Thr Phe Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr 305 310 315 320 Ser Leu Ser Ser Val Val
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 325 330 335 Thr Tyr Ile Cys
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 340 345 350 Lys Arg
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 355 360 365
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 370
375 380 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
Thr 385 390 395 400 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
Val Lys Phe Asn 405 410 415 Trp Tyr Val Asp Gly Val Glu Val His Asn
Ala Lys Thr Lys Pro Arg 420 425 430 Glu Glu Gln Tyr Asn Ser Thr Tyr
Arg Val Val Ser Val Leu Thr Val 435 440 445 Leu His Gln Asp Trp Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 450 455 460 Asn Lys Ala Leu
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 465 470 475 480 Gly
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 485 490
495 Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
500 505 510 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
Pro Glu 515 520 525 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe 530 535 540 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
Ser Arg Trp Gln Gln Gly 545 550 555 560 Asn Val Phe Ser Cys Ser Val
Met His Glu Ala Leu His Asn His Tyr 565 570 575 Thr Gln Lys Ser Leu
Ser Leu Ser Pro Gly Lys 580 585 59342PRTArtificial
Sequence3E10-Linker3-19G9 Light chain 59Asn Phe Met Leu Thr Gln Pro
His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser
Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln
Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile
Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55
60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr
Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu
Thr Val Leu Gly 100 105 110 Ala Gly Gly Gly Gly Ser Asp Asp Asp Asp
Lys Gly Gly Gly Gly Ser 115 120 125 Glu Ile Val Leu Thr Gln Ser Pro
Gly Thr Leu Ser Leu Ser Pro Gly 130 135 140 Glu Arg Ala Thr Leu Ser
Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 145 150 155 160 Tyr Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 165 170 175 Ile
Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 180 185
190 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
195 200 205 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser
Ser Leu 210 215 220 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
Thr Val Ala Ala 225 230 235 240 Pro Ser Val Phe Ile Phe Pro Pro Ser
Asp Glu Gln Leu Lys Ser Gly 245 250 255 Thr Ala Ser Val Val Cys Leu
Leu Asn Asn Phe Tyr Pro Arg Glu Ala 260 265 270 Lys Val Gln Trp Lys
Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 275 280 285 Glu Ser Val
Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 290 295 300 Ser
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 305 310
315 320 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
Ser 325 330 335 Phe Asn Arg Gly Glu Cys 340 60592PRTArtificial
Sequence3E10-Linker3-19G9 Heavy chain 60Gln Val Asn Leu Arg Glu Ser
Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser
Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser
Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser
Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55
60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr Trp Tyr
Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser
Ala Gly Gly Gly Gly Ser 115 120 125 Asp Asp Asp Asp Lys Gly Gly Gly
Gly Ser Glu Val Gln Leu Val Gln 130 135 140 Ser Gly Gly Gly Leu Val
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 145 150 155 160 Ala Gly Ser
Gly Phe Thr Phe Ser Ser Tyr Val Met His Trp Leu Arg 165 170 175 Gln
Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Gly Thr Gly 180 185
190 Gly Val Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser
195 200 205 Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser
Leu Arg 210 215 220 Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp
Gly Tyr Tyr Gly 225 230 235 240 Ser Gly Ser Tyr Glu Asn Asp Ala Phe
Asp Ile Trp Gly Gln Gly Thr 245 250 255 Met Val Thr Val Ser Ser Ala
Ser Thr Lys Gly Pro Ser Val Phe Pro 260 265 270 Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 275 280 285 Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 290 295 300 Ser
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 305 310
315 320 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
Ser 325 330 335 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
Lys Pro Ser 340 345 350 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys
Ser Cys Asp Lys Thr 355 360 365 His Thr Cys Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser 370 375 380 Val Phe Leu Phe Pro Pro Lys
Pro Lys Asp Thr Leu Met Ile Ser Arg 385 390 395 400 Thr Pro Glu Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 405 410 415 Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 420 425 430
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 435
440 445 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr 450 455 460 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
Glu Lys Thr 465 470 475 480 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu 485 490 495 Pro Pro Ser Arg Glu Glu Met Thr
Lys Asn Gln Val Ser Leu Thr Cys 500 505 510 Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 515 520 525 Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 530 535 540 Ser Asp
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 545 550 555
560 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
565 570 575 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 580 585 590 61342PRTArtificial Sequence3E10-Linker4-19G9
Light chain 61Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Ala Ser
Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly
Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro
Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn His Arg
Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr
Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr
Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn
Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105
110 Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser
Pro Gly 130 135 140 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser
Val Ser Ser Ser 145 150 155 160 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro
Gly Gln Ala Pro Arg Leu Leu 165 170 175 Ile Tyr Gly Ala Ser Ser Arg
Ala Thr Gly Ile Pro Asp Arg Phe Ser 180 185 190 Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 195 200 205 Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser Leu 210 215 220 Thr
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 225 230
235 240 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
Gly 245 250 255 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro
Arg Glu Ala 260 265 270 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
Ser Gly Asn Ser Gln 275 280 285 Glu Ser Val Thr Glu Gln Asp Ser Lys
Asp Ser Thr Tyr Ser Leu Ser 290 295 300 Ser Thr Leu Thr Leu Ser Lys
Ala Asp Tyr Glu Lys His Lys Val Tyr 305 310 315 320 Ala Cys Glu Val
Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 325 330 335 Phe Asn
Arg Gly Glu Cys 340 62592PRTArtificial Sequence3E10-Linker4-19G9
Heavy chain 62Gln Val Asn Leu Arg Glu Ser Gly Gly Thr Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly
Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Val Leu Ser Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105
110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser
115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu
Val Gln 130 135 140 Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu
Arg Leu Ser Cys 145 150 155 160 Ala Gly Ser Gly Phe Thr Phe Ser Ser
Tyr Val Met His Trp Leu Arg 165 170 175 Gln Ala Pro Gly Lys Gly Leu
Glu Trp Val Ser Val Ile Gly Thr Gly 180 185 190 Gly Val Thr His Tyr
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 195 200 205 Arg Asp Asn
Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 210 215 220 Ala
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Tyr Tyr Gly 225 230
235 240 Ser Gly Ser Tyr Glu Asn Asp Ala Phe Asp Ile Trp Gly Gln Gly
Thr 245 250 255 Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
Val Phe Pro 260 265 270 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
Thr Ala Ala Leu Gly 275 280 285 Cys Leu Val Lys Asp Tyr Phe Pro Glu
Pro Val Thr Val Ser Trp Asn 290 295 300 Ser Gly Ala Leu Thr Ser Gly
Val His Thr Phe Pro Ala Val Leu Gln 305 310 315 320 Ser Ser Gly Leu
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 325 330 335 Ser Leu
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 340 345 350
Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 355
360 365 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
Ser 370 375 380 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile Ser Arg 385 390 395 400 Thr Pro Glu Val Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro 405 410 415 Glu Val Lys Phe Asn Trp Tyr Val
Asp Gly Val Glu Val His Asn Ala 420 425 430 Lys Thr Lys Pro Arg Glu
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 435 440 445 Ser Val Leu Thr
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 450 455 460 Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 465 470 475
480 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
485 490 495 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
Thr Cys 500 505 510 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser 515 520 525 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp 530 535 540 Ser Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser 545 550 555 560 Arg Trp Gln Gln Gly
Asn Val Phe Ser Cys Ser Val Met His Glu Ala 565 570 575 Leu His Asn
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 580 585 590
63333PRTArtificial Sequence3E10-Link1-19G9 Fab Light chain 63Asp
Ile Val Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10
15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr
20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr
Thr Val 35 40 45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro
Asp Arg Phe Ser 50 55
60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr
Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu
Thr Val Leu Gly 100 105 110 Ala Ser Asp Asp Asp Asp Lys Glu Ile Val
Leu Thr Gln Ser Pro Gly 115 120 125 Thr Leu Ser Leu Ser Pro Gly Glu
Arg Ala Thr Leu Ser Cys Arg Ala 130 135 140 Ser Gln Ser Val Ser Ser
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 145 150 155 160 Gly Gln Ala
Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 165 170 175 Gly
Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 180 185
190 Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys
195 200 205 Gln Gln Tyr Ser Ser Ser Leu Thr Phe Gly Gly Gly Thr Lys
Val Glu 210 215 220 Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile
Phe Pro Pro Ser 225 230 235 240 Asp Glu Gln Leu Lys Ser Gly Thr Ala
Ser Val Val Cys Leu Leu Asn 245 250 255 Asn Phe Tyr Pro Arg Glu Ala
Lys Val Gln Trp Lys Val Asp Asn Ala 260 265 270 Leu Gln Ser Gly Asn
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 275 280 285 Asp Ser Thr
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 290 295 300 Tyr
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 305 310
315 320 Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Ala 325 330
64357PRTArtificial Sequence3E10-Link1-19G9 Fab Heavy chain 64Gln
Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10
15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala
20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu
Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr
Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala
Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu
Thr Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly
Thr Leu Val Thr Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys Glu
Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly 130 135 140
Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser 145
150 155 160 Tyr Val Met His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu
Glu Trp 165 170 175 Val Ser Val Ile Gly Thr Gly Gly Val Thr His Tyr
Ala Asp Ser Val 180 185 190 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Ala Lys Asn Ser Leu Tyr 195 200 205 Leu Gln Met Asn Ser Leu Arg Ala
Glu Asp Thr Ala Val Tyr Tyr Cys 210 215 220 Ala Arg Trp Gly Tyr Tyr
Gly Ser Gly Ser Tyr Glu Asn Asp Ala Phe 225 230 235 240 Asp Ile Trp
Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr 245 250 255 Lys
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 260 265
270 Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
275 280 285 Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
Val His 290 295 300 Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
Ser Leu Ser Ser 305 310 315 320 Val Val Thr Val Pro Ser Ser Ser Leu
Gly Thr Gln Thr Tyr Ile Cys 325 330 335 Asn Val Asn His Lys Pro Ser
Asn Thr Lys Val Asp Lys Lys Val Glu 340 345 350 Pro Lys Ser Glu Phe
355 65328PRTArtificial SequenceH1L5 Light chain 65Asp Ile Val Leu
Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val
Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35
40 45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe
Ser 50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr
Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys
Gln Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly Gly
Thr Lys Leu Thr Val Leu Gly 100 105 110 Asp Asp Asp Asp Lys Leu Thr
Gln Ser Pro Gly Thr Leu Ser Leu Ser 115 120 125 Pro Gly Glu Arg Ala
Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 130 135 140 Ser Ser Tyr
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 145 150 155 160
Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg 165
170 175 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
Arg 180 185 190 Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
Tyr Ser Ser 195 200 205 Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu
Ile Lys Arg Thr Val 210 215 220 Ala Ala Pro Ser Val Phe Ile Phe Pro
Pro Ser Asp Glu Gln Leu Lys 225 230 235 240 Ser Gly Thr Ala Ser Val
Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 245 250 255 Glu Ala Lys Val
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 260 265 270 Ser Gln
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 275 280 285
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 290
295 300 Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val
Thr 305 310 315 320 Lys Ser Phe Asn Arg Gly Glu Cys 325
66357PRTArtificial SequenceH1L5 Heavy chain 66Gln Val Gln Leu Val
Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40
45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val
50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr
Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys Glu Val Gln Leu Val
Gln Ser Gly Gly Gly Leu Val Gln Pro Gly 130 135 140 Gly Ser Leu Arg
Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser 145 150 155 160 Tyr
Val Met His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 165 170
175 Val Ser Val Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val
180 185 190 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser
Leu Tyr 195 200 205 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys 210 215 220 Ala Arg Trp Gly Tyr Tyr Gly Ser Gly Ser
Tyr Glu Asn Asp Ala Phe 225 230 235 240 Asp Ile Trp Gly Gln Gly Thr
Met Val Thr Val Ser Ser Ala Ser Thr 245 250 255 Lys Gly Pro Ser Val
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 260 265 270 Gly Gly Thr
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 275 280 285 Pro
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 290 295
300 Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
305 310 315 320 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
Tyr Ile Cys 325 330 335 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val
Asp Lys Lys Val Glu 340 345 350 Pro Lys Cys Glu Phe 355
67333PRTArtificial SequenceH2L1 Light chain 67Asp Ile Val Leu Thr
Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr
Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr
Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40
45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile
Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln
Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly 100 105 110 Ala Ser Asp Asp Asp Asp Lys Glu
Ile Val Leu Thr Gln Ser Pro Gly 115 120 125 Thr Leu Ser Leu Ser Pro
Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 130 135 140 Ser Gln Ser Val
Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 145 150 155 160 Gly
Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 165 170
175 Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
180 185 190 Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr
Tyr Cys 195 200 205 Gln Gln Tyr Ser Ser Ser Leu Thr Phe Gly Gly Gly
Thr Lys Val Glu 210 215 220 Ile Lys Arg Thr Val Ala Ala Pro Ser Val
Phe Ile Phe Pro Pro Ser 225 230 235 240 Asp Glu Gln Leu Lys Ser Gly
Thr Ala Ser Val Val Cys Leu Leu Asn 245 250 255 Asn Phe Tyr Pro Arg
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 260 265 270 Leu Gln Ser
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 275 280 285 Asp
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 290 295
300 Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu
305 310 315 320 Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
325 330 68354PRTArtificial SequenceH2L1 Heavy chain 68Gln Val Gln
Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25
30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val
35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly
Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp
Tyr Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu
Val Thr Val Asp Asp Asp Asp Lys Glu Val 115 120 125 Gln Leu Val Gln
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 130 135 140 Arg Leu
Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met 145 150 155
160 His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val
165 170 175 Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys
Gly Arg 180 185 190 Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
Tyr Leu Gln Met 195 200 205 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr Tyr Gly Ser Gly Ser Tyr
Glu Asn Asp Ala Phe Asp Ile Trp 225 230 235 240 Gly Gln Gly Thr Met
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 245 250 255 Ser Val Phe
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 260 265 270 Ala
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 275 280
285 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
290 295 300 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
Val Thr 305 310 315 320 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
Ile Cys Asn Val Asn 325 330 335 His Lys Pro Ser Asn Thr Lys Val Asp
Lys Lys Val Glu Pro Lys Cys 340 345 350 Glu Phe 69331PRTArtificial
SequenceH2L2 Light chain 69Asp Ile Val Leu Thr Gln Pro His Ser Val
Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg
Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln
Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp
Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser
Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85
90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
Gly 100 105 110 Asp Asp Asp Asp Lys Glu Ile Val Leu Thr Gln Ser Pro
Gly Thr Leu 115 120 125 Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser
Cys Arg Ala Ser Gln 130 135 140 Ser Val Ser Ser Ser Tyr Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln 145 150 155 160 Ala Pro Arg Leu Leu Ile
Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 165 170 175 Pro Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 180 185 190 Ile Ser
Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 195 200 205
Tyr Ser Ser Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 210
215 220 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
Glu 225 230 235 240 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
Leu Asn Asn Phe 245 250 255 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys
Val Asp Asn Ala Leu Gln 260 265
270 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
275 280 285 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
Tyr Glu 290 295 300 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln
Gly Leu Ser Ser 305 310 315 320 Pro Val Thr Lys Ser Phe Asn Arg Gly
Glu Cys 325 330 70354PRTArtificial SequenceH2L2 Heavy chain 70Gln
Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10
15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala
20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu
Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr
Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala
Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu
Thr Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly
Thr Leu Val Thr Val Asp Asp Asp Asp Lys Glu Val 115 120 125 Gln Leu
Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 130 135 140
Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met 145
150 155 160 His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
Ser Val 165 170 175 Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser
Val Lys Gly Arg 180 185 190 Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
Ser Leu Tyr Leu Gln Met 195 200 205 Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr Tyr Gly Ser Gly
Ser Tyr Glu Asn Asp Ala Phe Asp Ile Trp 225 230 235 240 Gly Gln Gly
Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 245 250 255 Ser
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 260 265
270 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
275 280 285 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
Phe Pro 290 295 300 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
Ser Val Val Thr 305 310 315 320 Val Pro Ser Ser Ser Leu Gly Thr Gln
Thr Tyr Ile Cys Asn Val Asn 325 330 335 His Lys Pro Ser Asn Thr Lys
Val Asp Lys Lys Val Glu Pro Lys Cys 340 345 350 Glu Phe
71332PRTArtificial SequenceH2L4 Light chain 71Asp Ile Val Leu Thr
Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr
Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr
Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40
45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile
Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln
Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly 100 105 110 Ala Ser Ala Ser Asp Asp Asp Asp
Lys Leu Thr Gln Ser Pro Gly Thr 115 120 125 Leu Ser Leu Ser Pro Gly
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 130 135 140 Gln Ser Val Ser
Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 145 150 155 160 Gln
Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly 165 170
175 Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
180 185 190 Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln 195 200 205 Gln Tyr Ser Ser Ser Leu Thr Phe Gly Gly Gly Thr
Lys Val Glu Ile 210 215 220 Lys Arg Thr Val Ala Ala Pro Ser Val Phe
Ile Phe Pro Pro Ser Asp 225 230 235 240 Glu Gln Leu Lys Ser Gly Thr
Ala Ser Val Val Cys Leu Leu Asn Asn 245 250 255 Phe Tyr Pro Arg Glu
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 260 265 270 Gln Ser Gly
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 275 280 285 Ser
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 290 295
300 Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
305 310 315 320 Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 325
330 72354PRTArtificial SequenceH2L4 Heavy chain 72Gln Val Gln Leu
Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35
40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser
Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr
Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val
Thr Val Asp Asp Asp Asp Lys Glu Val 115 120 125 Gln Leu Val Gln Ser
Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 130 135 140 Arg Leu Ser
Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met 145 150 155 160
His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val 165
170 175 Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys Gly
Arg 180 185 190 Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
Leu Gln Met 195 200 205 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr Tyr Gly Ser Gly Ser Tyr Glu
Asn Asp Ala Phe Asp Ile Trp 225 230 235 240 Gly Gln Gly Thr Met Val
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 245 250 255 Ser Val Phe Pro
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 260 265 270 Ala Ala
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 275 280 285
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 290
295 300 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
Thr 305 310 315 320 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
Cys Asn Val Asn 325 330 335 His Lys Pro Ser Asn Thr Lys Val Asp Lys
Lys Val Glu Pro Lys Cys 340 345 350 Glu Phe 73328PRTArtificial
SequenceH2L5 Light chain 73Asp Ile Val Leu Thr Gln Pro His Ser Val
Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg
Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln
Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp
Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser
Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85
90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
Gly 100 105 110 Asp Asp Asp Asp Lys Leu Thr Gln Ser Pro Gly Thr Leu
Ser Leu Ser 115 120 125 Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala
Ser Gln Ser Val Ser 130 135 140 Ser Ser Tyr Leu Ala Trp Tyr Gln Gln
Lys Pro Gly Gln Ala Pro Arg 145 150 155 160 Leu Leu Ile Tyr Gly Ala
Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg 165 170 175 Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 180 185 190 Leu Glu
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser 195 200 205
Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 210
215 220 Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu
Lys 225 230 235 240 Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
Phe Tyr Pro Arg 245 250 255 Glu Ala Lys Val Gln Trp Lys Val Asp Asn
Ala Leu Gln Ser Gly Asn 260 265 270 Ser Gln Glu Ser Val Thr Glu Gln
Asp Ser Lys Asp Ser Thr Tyr Ser 275 280 285 Leu Ser Ser Thr Leu Thr
Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 290 295 300 Val Tyr Ala Cys
Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 305 310 315 320 Lys
Ser Phe Asn Arg Gly Glu Cys 325 74354PRTArtificial SequenceH2L5
Heavy chain 74Gln Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln
Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro
Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly
Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Val Leu Ser Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105
110 Trp Gly Gln Gly Thr Leu Val Thr Val Asp Asp Asp Asp Lys Glu Val
115 120 125 Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
Ser Leu 130 135 140 Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser
Ser Tyr Val Met 145 150 155 160 His Trp Leu Arg Gln Ala Pro Gly Lys
Gly Leu Glu Trp Val Ser Val 165 170 175 Ile Gly Thr Gly Gly Val Thr
His Tyr Ala Asp Ser Val Lys Gly Arg 180 185 190 Phe Thr Ile Ser Arg
Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 195 200 205 Asn Ser Leu
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp 210 215 220 Gly
Tyr Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala Phe Asp Ile Trp 225 230
235 240 Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly
Pro 245 250 255 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
Gly Gly Thr 260 265 270 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
Pro Glu Pro Val Thr 275 280 285 Val Ser Trp Asn Ser Gly Ala Leu Thr
Ser Gly Val His Thr Phe Pro 290 295 300 Ala Val Leu Gln Ser Ser Gly
Leu Tyr Ser Leu Ser Ser Val Val Thr 305 310 315 320 Val Pro Ser Ser
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 325 330 335 His Lys
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Cys 340 345 350
Glu Phe 75327PRTArtificial SequenceH2L7 Light chain 75Asp Ile Val
Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr
Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25
30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val
35 40 45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg
Phe Ser 50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu
Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr
Cys Gln Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly
Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 Ala Ser Asp Asp Asp Asp
Lys Ser Pro Gly Thr Leu Ser Leu Ser Pro 115 120 125 Gly Glu Arg Ala
Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 130 135 140 Ser Tyr
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 145 150 155
160 Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe
165 170 175 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
Arg Leu 180 185 190 Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
Tyr Ser Ser Ser 195 200 205 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu
Ile Lys Arg Thr Val Ala 210 215 220 Ala Pro Ser Val Phe Ile Phe Pro
Pro Ser Asp Glu Gln Leu Lys Ser 225 230 235 240 Gly Thr Ala Ser Val
Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 245 250 255 Ala Lys Val
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 260 265 270 Gln
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 275 280
285 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
290 295 300 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val
Thr Lys 305 310 315 320 Ser Phe Asn Arg Gly Glu Cys 325
76354PRTArtificial SequenceH2L7 Heavy chain 76Gln Val Gln Leu Val
Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40
45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val
50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr
Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr
Val Asp Asp Asp Asp Lys Glu Val 115 120 125 Gln Leu Val Gln Ser Gly
Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 130 135 140 Arg Leu Ser Cys
Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met 145 150 155
160 His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val
165 170 175 Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys
Gly Arg 180 185 190 Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
Tyr Leu Gln Met 195 200 205 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr Tyr Gly Ser Gly Ser Tyr
Glu Asn Asp Ala Phe Asp Ile Trp 225 230 235 240 Gly Gln Gly Thr Met
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 245 250 255 Ser Val Phe
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 260 265 270 Ala
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 275 280
285 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
290 295 300 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
Val Thr 305 310 315 320 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
Ile Cys Asn Val Asn 325 330 335 His Lys Pro Ser Asn Thr Lys Val Asp
Lys Lys Val Glu Pro Lys Cys 340 345 350 Glu Phe 77325PRTArtificial
SequenceH2L8 Light chain 77Asp Ile Val Leu Thr Gln Pro His Ser Val
Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg
Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln
Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp
Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser
Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85
90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
Gly 100 105 110 Asp Asp Asp Asp Lys Ser Pro Gly Thr Leu Ser Leu Ser
Pro Gly Glu 115 120 125 Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser
Val Ser Ser Ser Tyr 130 135 140 Leu Ala Trp Tyr Gln Gln Lys Pro Gly
Gln Ala Pro Arg Leu Leu Ile 145 150 155 160 Tyr Gly Ala Ser Ser Arg
Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 165 170 175 Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 180 185 190 Glu Asp
Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser Leu Thr 195 200 205
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 210
215 220 Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
Thr 225 230 235 240 Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro
Arg Glu Ala Lys 245 250 255 Val Gln Trp Lys Val Asp Asn Ala Leu Gln
Ser Gly Asn Ser Gln Glu 260 265 270 Ser Val Thr Glu Gln Asp Ser Lys
Asp Ser Thr Tyr Ser Leu Ser Ser 275 280 285 Thr Leu Thr Leu Ser Lys
Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 290 295 300 Cys Glu Val Thr
His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 305 310 315 320 Asn
Arg Gly Glu Cys 325 78354PRTArtificial SequenceH2L8 Heavy chain
78Gln Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1
5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp
Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu
Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser
Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln
Gly Thr Leu Val Thr Val Asp Asp Asp Asp Lys Glu Val 115 120 125 Gln
Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 130 135
140 Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met
145 150 155 160 His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val Ser Val 165 170 175 Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp
Ser Val Lys Gly Arg 180 185 190 Phe Thr Ile Ser Arg Asp Asn Ala Lys
Asn Ser Leu Tyr Leu Gln Met 195 200 205 Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr Tyr Gly Ser
Gly Ser Tyr Glu Asn Asp Ala Phe Asp Ile Trp 225 230 235 240 Gly Gln
Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 245 250 255
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 260
265 270 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
Thr 275 280 285 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
Thr Phe Pro 290 295 300 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
Ser Ser Val Val Thr 305 310 315 320 Val Pro Ser Ser Ser Leu Gly Thr
Gln Thr Tyr Ile Cys Asn Val Asn 325 330 335 His Lys Pro Ser Asn Thr
Lys Val Asp Lys Lys Val Glu Pro Lys Cys 340 345 350 Glu Phe
79330PRTArtificial Sequence3E10-Linker1a-19G9 Light chain 79Asn Phe
Met Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20
25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr
Val 35 40 45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp
Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser
Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr
Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly
Gly Gly Thr Lys Leu Thr Val Ser Asp 100 105 110 Asp Asp Asp Lys Glu
Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 115 120 125 Leu Ser Pro
Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 130 135 140 Val
Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 145 150
155 160 Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile
Pro 165 170 175 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
Leu Thr Ile 180 185 190 Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr
Tyr Cys Gln Gln Tyr 195 200 205 Ser Ser Ser Leu Thr Phe Gly Gly Gly
Thr Lys Val Glu Ile Lys Arg 210 215 220 Thr Val Ala Ala Pro Ser Val
Phe Ile Phe Pro Pro Ser Asp Glu Gln 225 230 235 240 Leu Lys Ser Gly
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 245 250 255 Pro Arg
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 260 265 270
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 275
280 285 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
Lys 290 295 300 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu
Ser Ser Pro 305 310 315 320 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
325 330 80580PRTArtificial Sequence3E10-Linker1a-19G9 Heavy chain
80Gln Val Asn Leu Arg Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1
5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp
Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu
Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser
Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln
Gly Thr Leu Val Thr Val Asp Asp Asp Asp Lys Glu Val 115 120 125 Gln
Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 130 135
140 Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met
145 150 155 160 His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
Val Ser Val 165 170 175 Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp
Ser Val Lys Gly Arg 180 185 190 Phe Thr Ile Ser Arg Asp Asn Ala Lys
Asn Ser Leu Tyr Leu Gln Met 195 200 205 Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr Tyr Gly Ser
Gly Ser Tyr Glu Asn Asp Ala Phe Asp Ile Trp 225 230 235 240 Gly Gln
Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 245 250 255
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 260
265 270 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
Thr 275 280 285 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
Thr Phe Pro 290 295 300 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
Ser Ser Val Val Thr 305 310 315 320 Val Pro Ser Ser Ser Leu Gly Thr
Gln Thr Tyr Ile Cys Asn Val Asn 325 330 335 His Lys Pro Ser Asn Thr
Lys Val Asp Lys Arg Val Glu Pro Lys Ser 340 345 350 Cys Asp Lys Thr
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 355 360 365 Gly Gly
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 370 375 380
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 385
390 395 400 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
Val Glu 405 410 415 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
Tyr Asn Ser Thr 420 425 430 Tyr Arg Val Val Ser Val Leu Thr Val Leu
His Gln Asp Trp Leu Asn 435 440 445 Gly Lys Glu Tyr Lys Cys Lys Val
Ser Asn Lys Ala Leu Pro Ala Pro 450 455 460 Ile Glu Lys Thr Ile Ser
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 465 470 475 480 Val Tyr Thr
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 485 490 495 Ser
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 500 505
510 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
515 520 525 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
Leu Thr 530 535 540 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
Ser Cys Ser Val 545 550 555 560 Met His Glu Ala Leu His Asn His Tyr
Thr Gln Lys Ser Leu Ser Leu 565 570 575 Ser Pro Gly Lys 580
81327PRTArtificial Sequence3E10-Linker1b-19G9 Light chain 81Asn Phe
Met Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20
25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr
Val 35 40 45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp
Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser
Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr
Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly
Gly Gly Thr Lys Leu Thr Val Ser Asp 100 105 110 Asp Asp Asp Lys Leu
Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 115 120 125 Gly Glu Arg
Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 130 135 140 Ser
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 145 150
155 160 Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg
Phe 165 170 175 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
Ser Arg Leu 180 185 190 Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln
Gln Tyr Ser Ser Ser 195 200 205 Leu Thr Phe Gly Gly Gly Thr Lys Val
Glu Ile Lys Arg Thr Val Ala 210 215 220 Ala Pro Ser Val Phe Ile Phe
Pro Pro Ser Asp Glu Gln Leu Lys Ser 225 230 235 240 Gly Thr Ala Ser
Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 245 250 255 Ala Lys
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 260 265 270
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 275
280 285 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
Val 290 295 300 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
Val Thr Lys 305 310 315 320 Ser Phe Asn Arg Gly Glu Cys 325
82575PRTArtificial Sequence3E10-Linker1b-19G9 Heavy chain 82Gln Val
Asn Leu Arg Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20
25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp
Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala
Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr
Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr
Leu Val Thr Val Asp Asp Asp Asp Lys Gln Ser 115 120 125 Gly Gly Gly
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 130 135 140 Gly
Ser Gly Phe Thr Phe Ser Ser Tyr Val Met His Trp
Leu Arg Gln 145 150 155 160 Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
Val Ile Gly Thr Gly Gly 165 170 175 Val Thr His Tyr Ala Asp Ser Val
Lys Gly Arg Phe Thr Ile Ser Arg 180 185 190 Asp Asn Ala Lys Asn Ser
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 195 200 205 Glu Asp Thr Ala
Val Tyr Tyr Cys Ala Arg Trp Gly Tyr Tyr Gly Ser 210 215 220 Gly Ser
Tyr Glu Asn Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 225 230 235
240 Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu
245 250 255 Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
Gly Cys 260 265 270 Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
Ser Trp Asn Ser 275 280 285 Gly Ala Leu Thr Ser Gly Val His Thr Phe
Pro Ala Val Leu Gln Ser 290 295 300 Ser Gly Leu Tyr Ser Leu Ser Ser
Val Val Thr Val Pro Ser Ser Ser 305 310 315 320 Leu Gly Thr Gln Thr
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 325 330 335 Thr Lys Val
Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 340 345 350 Thr
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 355 360
365 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
370 375 380 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
Pro Glu 385 390 395 400 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
Val His Asn Ala Lys 405 410 415 Thr Lys Pro Arg Glu Glu Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser 420 425 430 Val Leu Thr Val Leu His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys 435 440 445 Cys Lys Val Ser Asn
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 450 455 460 Ser Lys Ala
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 465 470 475 480
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 485
490 495 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn 500 505 510 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser 515 520 525 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys Ser Arg 530 535 540 Trp Gln Gln Gly Asn Val Phe Ser Cys
Ser Val Met His Glu Ala Leu 545 550 555 560 His Asn His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys 565 570 575 83330PRTArtificial
Sequence3E10-Linker1c-19G9 Light chain 83Asn Phe Met Leu Thr Gln
Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile
Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr Val
Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45
Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50
55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser
Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser
Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr Lys
Leu Thr Val Leu Gly 100 105 110 Ala Ser Asp Asp Asp Asp Lys Leu Thr
Gln Ser Pro Gly Thr Leu Ser 115 120 125 Leu Ser Pro Gly Glu Arg Ala
Thr Leu Ser Cys Arg Ala Ser Gln Ser 130 135 140 Val Ser Ser Ser Tyr
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 145 150 155 160 Pro Arg
Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 165 170 175
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 180
185 190 Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
Tyr 195 200 205 Ser Ser Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu
Ile Lys Arg 210 215 220 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro
Pro Ser Asp Glu Gln 225 230 235 240 Leu Lys Ser Gly Thr Ala Ser Val
Val Cys Leu Leu Asn Asn Phe Tyr 245 250 255 Pro Arg Glu Ala Lys Val
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 260 265 270 Gly Asn Ser Gln
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 275 280 285 Tyr Ser
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 290 295 300
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 305
310 315 320 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 325 330
84578PRTArtificial Sequence3E10-Linker1c-19G9 Heavy chain 84Gln Val
Asn Leu Arg Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20
25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp
Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala
Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr
Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr
Leu Val Thr Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys Gln Ser
Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 130 135 140 Ser
Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met His Trp 145 150
155 160 Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile
Gly 165 170 175 Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys Gly
Arg Phe Thr 180 185 190 Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
Leu Gln Met Asn Ser 195 200 205 Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys Ala Arg Trp Gly Tyr 210 215 220 Tyr Gly Ser Gly Ser Tyr Glu
Asn Asp Ala Phe Asp Ile Trp Gly Gln 225 230 235 240 Gly Thr Met Val
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 245 250 255 Phe Pro
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 260 265 270
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 275
280 285 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
Val 290 295 300 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
Thr Val Pro 305 310 315 320 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
Cys Asn Val Asn His Lys 325 330 335 Pro Ser Asn Thr Lys Val Asp Lys
Arg Val Glu Pro Lys Ser Cys Asp 340 345 350 Lys Thr His Thr Cys Pro
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 355 360 365 Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 370 375 380 Ser Arg
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 385 390 395
400 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
405 410 415 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
Tyr Arg 420 425 430 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys 435 440 445 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
Leu Pro Ala Pro Ile Glu 450 455 460 Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro Arg Glu Pro Gln Val Tyr 465 470 475 480 Thr Leu Pro Pro Ser
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 485 490 495 Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 500 505 510 Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 515 520
525 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
530 535 540 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
Met His 545 550 555 560 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro 565 570 575 Gly Lys 85333PRTArtificial
SequenceH3L1 Light chain 85Asp Ile Val Leu Thr Gln Pro His Ser Val
Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg
Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln
Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp
Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser
Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85
90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
Gly 100 105 110 Ala Ser Asp Asp Asp Asp Lys Glu Ile Val Leu Thr Gln
Ser Pro Gly 115 120 125 Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr
Leu Ser Cys Arg Ala 130 135 140 Ser Gln Ser Val Ser Ser Ser Tyr Leu
Ala Trp Tyr Gln Gln Lys Pro 145 150 155 160 Gly Gln Ala Pro Arg Leu
Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 165 170 175 Gly Ile Pro Asp
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 180 185 190 Leu Thr
Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 195 200 205
Gln Gln Tyr Ser Ser Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 210
215 220 Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
Ser 225 230 235 240 Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val
Cys Leu Leu Asn 245 250 255 Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln
Trp Lys Val Asp Asn Ala 260 265 270 Leu Gln Ser Gly Asn Ser Gln Glu
Ser Val Thr Glu Gln Asp Ser Lys 275 280 285 Asp Ser Thr Tyr Ser Leu
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 290 295 300 Tyr Glu Lys His
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 305 310 315 320 Ser
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 325 330
86352PRTArtificial SequenceH3L1 Heavy chain 86Gln Val Gln Leu Val
Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40
45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val
50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr
Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys Gln Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 130 135 140 Ser Cys Ala Gly
Ser Gly Phe Thr Phe Ser Ser Tyr Val Met His Trp 145 150 155 160 Leu
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Gly 165 170
175 Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr
180 185 190 Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met
Asn Ser 195 200 205 Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
Arg Trp Gly Tyr 210 215 220 Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala
Phe Asp Ile Trp Gly Gln 225 230 235 240 Gly Thr Met Val Thr Val Ser
Ser Ala Ser Thr Lys Gly Pro Ser Val 245 250 255 Phe Pro Leu Ala Pro
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 260 265 270 Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 275 280 285 Trp
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 290 295
300 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
305 310 315 320 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
Asn His Lys 325 330 335 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
Pro Lys Cys Glu Phe 340 345 350 87331PRTArtificial SequenceH3L2
Light chain 87Asp Ile Val Leu Thr Gln Pro His Ser Val Ser Ala Ser
Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly
Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro
Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn His Arg
Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr
Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr
Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn
Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105
110 Asp Asp Asp Asp Lys Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu
115 120 125 Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala
Ser Gln 130 135 140 Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln
Lys Pro Gly Gln 145 150 155 160 Ala Pro Arg Leu Leu Ile Tyr Gly Ala
Ser Ser Arg Ala Thr Gly Ile 165 170 175 Pro Asp Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Thr 180 185 190 Ile Ser Arg Leu Glu
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 195 200 205 Tyr Ser Ser
Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 210 215 220 Arg
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 225 230
235 240 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
Phe 245 250
255 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
260 265 270 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys
Asp Ser 275 280 285 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
Ala Asp Tyr Glu 290 295 300 Lys His Lys Val Tyr Ala Cys Glu Val Thr
His Gln Gly Leu Ser Ser 305 310 315 320 Pro Val Thr Lys Ser Phe Asn
Arg Gly Glu Cys 325 330 88352PRTArtificial SequenceH3L2 Heavy chain
88Gln Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1
5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp
Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu
Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser
Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln
Gly Thr Leu Val Thr Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys
Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 130 135
140 Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met His Trp
145 150 155 160 Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
Val Ile Gly 165 170 175 Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val
Lys Gly Arg Phe Thr 180 185 190 Ile Ser Arg Asp Asn Ala Lys Asn Ser
Leu Tyr Leu Gln Met Asn Ser 195 200 205 Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys Ala Arg Trp Gly Tyr 210 215 220 Tyr Gly Ser Gly Ser
Tyr Glu Asn Asp Ala Phe Asp Ile Trp Gly Gln 225 230 235 240 Gly Thr
Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 245 250 255
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 260
265 270 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
Ser 275 280 285 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
Pro Ala Val 290 295 300 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
Val Val Thr Val Pro 305 310 315 320 Ser Ser Ser Leu Gly Thr Gln Thr
Tyr Ile Cys Asn Val Asn His Lys 325 330 335 Pro Ser Asn Thr Lys Val
Asp Lys Lys Val Glu Pro Lys Cys Glu Phe 340 345 350
89330PRTArtificial SequenceH3L4 Light chain 89Asp Ile Val Leu Thr
Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr
Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr
Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40
45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile
Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln
Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly 100 105 110 Ala Ser Asp Asp Asp Asp Lys Leu
Thr Gln Ser Pro Gly Thr Leu Ser 115 120 125 Leu Ser Pro Gly Glu Arg
Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 130 135 140 Val Ser Ser Ser
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 145 150 155 160 Pro
Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 165 170
175 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
180 185 190 Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln
Gln Tyr 195 200 205 Ser Ser Ser Leu Thr Phe Gly Gly Gly Thr Lys Val
Glu Ile Lys Arg 210 215 220 Thr Val Ala Ala Pro Ser Val Phe Ile Phe
Pro Pro Ser Asp Glu Gln 225 230 235 240 Leu Lys Ser Gly Thr Ala Ser
Val Val Cys Leu Leu Asn Asn Phe Tyr 245 250 255 Pro Arg Glu Ala Lys
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 260 265 270 Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 275 280 285 Tyr
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 290 295
300 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
305 310 315 320 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 325 330
90352PRTArtificial SequenceH3L4 Heavy chain 90Gln Val Gln Leu Val
Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40
45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val
50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr
Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys Gln Ser Gly Gly Gly
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 130 135 140 Ser Cys Ala Gly
Ser Gly Phe Thr Phe Ser Ser Tyr Val Met His Trp 145 150 155 160 Leu
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Gly 165 170
175 Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr
180 185 190 Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met
Asn Ser 195 200 205 Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
Arg Trp Gly Tyr 210 215 220 Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala
Phe Asp Ile Trp Gly Gln 225 230 235 240 Gly Thr Met Val Thr Val Ser
Ser Ala Ser Thr Lys Gly Pro Ser Val 245 250 255 Phe Pro Leu Ala Pro
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 260 265 270 Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 275 280 285 Trp
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 290 295
300 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
305 310 315 320 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
Asn His Lys 325 330 335 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
Pro Lys Cys Glu Phe 340 345 350 91328PRTArtificial SequenceH3L5
Light chain 91Asp Ile Val Leu Thr Gln Pro His Ser Val Ser Ala Ser
Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly
Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro
Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn His Arg
Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr
Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr
Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn
Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105
110 Asp Asp Asp Asp Lys Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser
115 120 125 Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser
Val Ser 130 135 140 Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly
Gln Ala Pro Arg 145 150 155 160 Leu Leu Ile Tyr Gly Ala Ser Ser Arg
Ala Thr Gly Ile Pro Asp Arg 165 170 175 Phe Ser Gly Ser Gly Ser Gly
Thr Asp Phe Thr Leu Thr Ile Ser Arg 180 185 190 Leu Glu Pro Glu Asp
Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser 195 200 205 Ser Leu Thr
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 210 215 220 Ala
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 225 230
235 240 Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro
Arg 245 250 255 Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
Ser Gly Asn 260 265 270 Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys
Asp Ser Thr Tyr Ser 275 280 285 Leu Ser Ser Thr Leu Thr Leu Ser Lys
Ala Asp Tyr Glu Lys His Lys 290 295 300 Val Tyr Ala Cys Glu Val Thr
His Gln Gly Leu Ser Ser Pro Val Thr 305 310 315 320 Lys Ser Phe Asn
Arg Gly Glu Cys 325 92352PRTArtificial SequenceH3L5 Heavy chain
92Gln Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1
5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp
Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu
Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr
Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp
Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser
Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln
Gly Thr Leu Val Thr Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys
Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 130 135
140 Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met His Trp
145 150 155 160 Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
Val Ile Gly 165 170 175 Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val
Lys Gly Arg Phe Thr 180 185 190 Ile Ser Arg Asp Asn Ala Lys Asn Ser
Leu Tyr Leu Gln Met Asn Ser 195 200 205 Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys Ala Arg Trp Gly Tyr 210 215 220 Tyr Gly Ser Gly Ser
Tyr Glu Asn Asp Ala Phe Asp Ile Trp Gly Gln 225 230 235 240 Gly Thr
Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 245 250 255
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 260
265 270 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
Ser 275 280 285 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
Pro Ala Val 290 295 300 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
Val Val Thr Val Pro 305 310 315 320 Ser Ser Ser Leu Gly Thr Gln Thr
Tyr Ile Cys Asn Val Asn His Lys 325 330 335 Pro Ser Asn Thr Lys Val
Asp Lys Lys Val Glu Pro Lys Cys Glu Phe 340 345 350
93327PRTArtificial SequenceH3L7 Light chain 93Asp Ile Val Leu Thr
Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr
Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr
Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40
45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile
Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln
Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly 100 105 110 Ala Ser Asp Asp Asp Asp Lys Ser
Pro Gly Thr Leu Ser Leu Ser Pro 115 120 125 Gly Glu Arg Ala Thr Leu
Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 130 135 140 Ser Tyr Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 145 150 155 160 Leu
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 165 170
175 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu
180 185 190 Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser
Ser Ser 195 200 205 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
Arg Thr Val Ala 210 215 220 Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
Asp Glu Gln Leu Lys Ser 225 230 235 240 Gly Thr Ala Ser Val Val Cys
Leu Leu Asn Asn Phe Tyr Pro Arg Glu 245 250 255 Ala Lys Val Gln Trp
Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 260 265 270 Gln Glu Ser
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 275 280 285 Ser
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 290 295
300 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
305 310 315 320 Ser Phe Asn Arg Gly Glu Cys 325 94352PRTArtificial
SequenceH3L7 Heavy chain 94Gln Val Gln Leu Val Glu Ser Gly Gly Thr
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp
Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ser Asp
Asp Asp Asp 115 120 125 Lys Gln Ser Gly Gly Gly Leu Val Gln Pro Gly
Gly Ser Leu Arg Leu 130 135 140
Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met His Trp 145
150 155 160 Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val
Ile Gly 165 170 175 Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys
Gly Arg Phe Thr 180 185 190 Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
Tyr Leu Gln Met Asn Ser 195 200 205 Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys Ala Arg Trp Gly Tyr 210 215 220 Tyr Gly Ser Gly Ser Tyr
Glu Asn Asp Ala Phe Asp Ile Trp Gly Gln 225 230 235 240 Gly Thr Met
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 245 250 255 Phe
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 260 265
270 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
275 280 285 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
Ala Val 290 295 300 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
Val Thr Val Pro 305 310 315 320 Ser Ser Ser Leu Gly Thr Gln Thr Tyr
Ile Cys Asn Val Asn His Lys 325 330 335 Pro Ser Asn Thr Lys Val Asp
Lys Lys Val Glu Pro Lys Cys Glu Phe 340 345 350 95331PRTArtificial
SequenceH1L2 Light chain 95Asp Ile Val Leu Thr Gln Pro His Ser Val
Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg
Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln
Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp
Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser
Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85
90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
Gly 100 105 110 Asp Asp Asp Asp Lys Glu Ile Val Leu Thr Gln Ser Pro
Gly Thr Leu 115 120 125 Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser
Cys Arg Ala Ser Gln 130 135 140 Ser Val Ser Ser Ser Tyr Leu Ala Trp
Tyr Gln Gln Lys Pro Gly Gln 145 150 155 160 Ala Pro Arg Leu Leu Ile
Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 165 170 175 Pro Asp Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 180 185 190 Ile Ser
Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 195 200 205
Tyr Ser Ser Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 210
215 220 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
Glu 225 230 235 240 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
Leu Asn Asn Phe 245 250 255 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys
Val Asp Asn Ala Leu Gln 260 265 270 Ser Gly Asn Ser Gln Glu Ser Val
Thr Glu Gln Asp Ser Lys Asp Ser 275 280 285 Thr Tyr Ser Leu Ser Ser
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 290 295 300 Lys His Lys Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 305 310 315 320 Pro
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 325 330 96357PRTArtificial
SequenceH1L2 Heavy chain 96Gln Val Gln Leu Val Glu Ser Gly Gly Thr
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp
Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ser Asp
Asp Asp Asp 115 120 125 Lys Glu Val Gln Leu Val Gln Ser Gly Gly Gly
Leu Val Gln Pro Gly 130 135 140 Gly Ser Leu Arg Leu Ser Cys Ala Gly
Ser Gly Phe Thr Phe Ser Ser 145 150 155 160 Tyr Val Met His Trp Leu
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 165 170 175 Val Ser Val Ile
Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val 180 185 190 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 195 200 205
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 210
215 220 Ala Arg Trp Gly Tyr Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala
Phe 225 230 235 240 Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser
Ser Ala Ser Thr 245 250 255 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Ser Ser Lys Ser Thr Ser 260 265 270 Gly Gly Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro Glu 275 280 285 Pro Val Thr Val Ser Trp
Asn Ser Gly Ala Leu Thr Ser Gly Val His 290 295 300 Thr Phe Pro Ala
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 305 310 315 320 Val
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 325 330
335 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
340 345 350 Pro Lys Cys Glu Phe 355 97333PRTArtificial SequenceH5L1
Light chain 97Asp Ile Val Leu Thr Gln Pro His Ser Val Ser Ala Ser
Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly
Ser Val Ala Ser Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro
Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn His Arg
Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr
Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr
Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn
Asn Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105
110 Ala Ser Asp Asp Asp Asp Lys Glu Ile Val Leu Thr Gln Ser Pro Gly
115 120 125 Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys
Arg Ala 130 135 140 Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr
Gln Gln Lys Pro 145 150 155 160 Gly Gln Ala Pro Arg Leu Leu Ile Tyr
Gly Ala Ser Ser Arg Ala Thr 165 170 175 Gly Ile Pro Asp Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Phe Thr 180 185 190 Leu Thr Ile Ser Arg
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 195 200 205 Gln Gln Tyr
Ser Ser Ser Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 210 215 220 Ile
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 225 230
235 240 Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
Asn 245 250 255 Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val
Asp Asn Ala 260 265 270 Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr
Glu Gln Asp Ser Lys 275 280 285 Asp Ser Thr Tyr Ser Leu Ser Ser Thr
Leu Thr Leu Ser Lys Ala Asp 290 295 300 Tyr Glu Lys His Lys Val Tyr
Ala Cys Glu Val Thr His Gln Gly Leu 305 310 315 320 Ser Ser Pro Val
Thr Lys Ser Phe Asn Arg Gly Glu Cys 325 330 98347PRTArtificial
SequenceH5L1 Heavy chain 98Gln Val Gln Leu Val Glu Ser Gly Gly Thr
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp
Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ser Asp
Asp Asp Asp 115 120 125 Lys Leu Val Gln Pro Gly Gly Ser Leu Arg Leu
Ser Cys Ala Gly Ser 130 135 140 Gly Phe Thr Phe Ser Ser Tyr Val Met
His Trp Leu Arg Gln Ala Pro 145 150 155 160 Gly Lys Gly Leu Glu Trp
Val Ser Val Ile Gly Thr Gly Gly Val Thr 165 170 175 His Tyr Ala Asp
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 180 185 190 Ala Lys
Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 195 200 205
Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Tyr Tyr Gly Ser Gly Ser 210
215 220 Tyr Glu Asn Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val
Thr 225 230 235 240 Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
Pro Leu Ala Pro 245 250 255 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
Ala Leu Gly Cys Leu Val 260 265 270 Lys Asp Tyr Phe Pro Glu Pro Val
Thr Val Ser Trp Asn Ser Gly Ala 275 280 285 Leu Thr Ser Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 290 295 300 Leu Tyr Ser Leu
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 305 310 315 320 Thr
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 325 330
335 Val Asp Lys Lys Val Glu Pro Lys Cys Glu Phe 340 345
99330PRTArtificial SequenceH5L4 Light chain 99Asp Ile Val Leu Thr
Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr
Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr
Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40
45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile
Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln
Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly 100 105 110 Ala Ser Asp Asp Asp Asp Lys Leu
Thr Gln Ser Pro Gly Thr Leu Ser 115 120 125 Leu Ser Pro Gly Glu Arg
Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 130 135 140 Val Ser Ser Ser
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 145 150 155 160 Pro
Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 165 170
175 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
180 185 190 Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln
Gln Tyr 195 200 205 Ser Ser Ser Leu Thr Phe Gly Gly Gly Thr Lys Val
Glu Ile Lys Arg 210 215 220 Thr Val Ala Ala Pro Ser Val Phe Ile Phe
Pro Pro Ser Asp Glu Gln 225 230 235 240 Leu Lys Ser Gly Thr Ala Ser
Val Val Cys Leu Leu Asn Asn Phe Tyr 245 250 255 Pro Arg Glu Ala Lys
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 260 265 270 Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 275 280 285 Tyr
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 290 295
300 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
305 310 315 320 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 325 330
100347PRTArtificial SequenceH5L4 Heavy chain 100Gln Val Gln Leu Val
Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40
45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val
50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr
Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys Leu Val Gln Pro Gly
Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser 130 135 140 Gly Phe Thr Phe
Ser Ser Tyr Val Met His Trp Leu Arg Gln Ala Pro 145 150 155 160 Gly
Lys Gly Leu Glu Trp Val Ser Val Ile Gly Thr Gly Gly Val Thr 165 170
175 His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
180 185 190 Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
Glu Asp 195 200 205 Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Tyr Tyr
Gly Ser Gly Ser 210 215 220 Tyr Glu Asn Asp Ala Phe Asp Ile Trp Gly
Gln Gly Thr Met Val Thr 225 230 235 240 Val Ser Ser Ala Ser Thr Lys
Gly Pro Ser Val Phe Pro Leu Ala Pro 245 250 255 Ser Ser Lys Ser Thr
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 260 265 270 Lys Asp Tyr
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 275 280 285 Leu
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 290 295
300 Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
305 310 315 320 Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
Asn Thr Lys 325 330 335 Val Asp Lys Lys Val Glu Pro Lys Cys Glu Phe
340 345 101327PRTArtificial SequenceH5L7 Light chain 101Asp Ile Val
Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1
5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser
Tyr 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro
Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val
Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser
Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala
Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 Ala Ser Asp
Asp Asp Asp Lys Ser Pro Gly Thr Leu Ser Leu Ser Pro 115 120 125 Gly
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 130 135
140 Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu
145 150 155 160 Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro
Asp Arg Phe 165 170 175 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Thr Ile Ser Arg Leu 180 185 190 Glu Pro Glu Asp Phe Ala Val Tyr Tyr
Cys Gln Gln Tyr Ser Ser Ser 195 200 205 Leu Thr Phe Gly Gly Gly Thr
Lys Val Glu Ile Lys Arg Thr Val Ala 210 215 220 Ala Pro Ser Val Phe
Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 225 230 235 240 Gly Thr
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 245 250 255
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 260
265 270 Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
Leu 275 280 285 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
His Lys Val 290 295 300 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
Ser Pro Val Thr Lys 305 310 315 320 Ser Phe Asn Arg Gly Glu Cys 325
102347PRTArtificial SequenceH5L7 Heavy chain 102Gln Val Gln Leu Val
Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg
Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40
45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val
50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr
Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr
Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys Leu Val Gln Pro Gly
Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser 130 135 140 Gly Phe Thr Phe
Ser Ser Tyr Val Met His Trp Leu Arg Gln Ala Pro 145 150 155 160 Gly
Lys Gly Leu Glu Trp Val Ser Val Ile Gly Thr Gly Gly Val Thr 165 170
175 His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
180 185 190 Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
Glu Asp 195 200 205 Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Tyr Tyr
Gly Ser Gly Ser 210 215 220 Tyr Glu Asn Asp Ala Phe Asp Ile Trp Gly
Gln Gly Thr Met Val Thr 225 230 235 240 Val Ser Ser Ala Ser Thr Lys
Gly Pro Ser Val Phe Pro Leu Ala Pro 245 250 255 Ser Ser Lys Ser Thr
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 260 265 270 Lys Asp Tyr
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 275 280 285 Leu
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 290 295
300 Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
305 310 315 320 Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
Asn Thr Lys 325 330 335 Val Asp Lys Lys Val Glu Pro Lys Cys Glu Phe
340 345 103325PRTArtificial SequenceH5L8 Light chain 103Asp Ile Val
Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr
Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25
30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val
35 40 45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg
Phe Ser 50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu
Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr
Cys Gln Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly
Gly Thr Lys Leu Thr Val Leu Gly 100 105 110 Asp Asp Asp Asp Lys Ser
Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu 115 120 125 Arg Ala Thr Leu
Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr 130 135 140 Leu Ala
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 145 150 155
160 Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly
165 170 175 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu
Glu Pro 180 185 190 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser
Ser Ser Leu Thr 195 200 205 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
Arg Thr Val Ala Ala Pro 210 215 220 Ser Val Phe Ile Phe Pro Pro Ser
Asp Glu Gln Leu Lys Ser Gly Thr 225 230 235 240 Ala Ser Val Val Cys
Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 245 250 255 Val Gln Trp
Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 260 265 270 Ser
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 275 280
285 Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
290 295 300 Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
Ser Phe 305 310 315 320 Asn Arg Gly Glu Cys 325 104347PRTArtificial
SequenceH5L8 Heavy chain 104Gln Val Gln Leu Val Glu Ser Gly Gly Thr
Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala
Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val Arg
Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser
Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys Gly
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Val Leu Ser Leu Thr Asp Tyr Tyr Trp Tyr Gly Met Asp
Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ser Asp
Asp Asp Asp 115 120 125 Lys Leu Val Gln Pro Gly Gly Ser Leu Arg Leu
Ser Cys Ala Gly Ser 130 135 140 Gly Phe Thr Phe Ser Ser Tyr Val Met
His Trp Leu Arg Gln Ala Pro 145 150 155 160 Gly Lys Gly Leu Glu Trp
Val Ser Val Ile Gly Thr Gly Gly Val Thr 165 170 175 His Tyr Ala Asp
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 180 185 190 Ala Lys
Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 195 200 205
Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Tyr Tyr Gly Ser Gly Ser 210
215 220 Tyr Glu Asn Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val
Thr 225 230 235 240 Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
Pro Leu Ala Pro 245 250 255 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
Ala Leu Gly Cys Leu Val 260 265 270 Lys Asp Tyr Phe Pro Glu Pro Val
Thr Val Ser Trp Asn Ser Gly Ala 275 280 285 Leu Thr Ser Gly Val His
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 290 295 300 Leu Tyr Ser Leu
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 305 310 315 320 Thr
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 325 330
335 Val Asp Lys Lys Val Glu Pro Lys Cys Glu Phe 340 345
105333PRTArtificial SequenceH6L1 Light chain 105Asp Ile Val Leu Thr
Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr
Ile Ser Cys Thr Arg Ser Ser Gly Ser Val Ala Ser Tyr 20 25 30 Tyr
Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40
45 Ile Tyr Glu Asp Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60 Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile
Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln
Ser Tyr Asp Ser 85 90 95 Asn Asn Leu Val Val Phe Gly Gly Gly Thr
Lys Leu Thr Val Leu Gly 100 105 110 Ala Ser Asp Asp Asp Asp Lys Glu
Ile Val Leu Thr Gln Ser Pro Gly 115 120 125 Thr Leu Ser Leu Ser Pro
Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 130 135 140 Ser Gln Ser Val
Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 145 150 155 160 Gly
Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 165 170
175 Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
180 185 190 Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr
Tyr Cys 195 200 205 Gln Gln Tyr Ser Ser Ser Leu Thr Phe Gly Gly Gly
Thr Lys Val Glu 210 215 220 Ile Lys Arg Thr Val Ala Ala Pro Ser Val
Phe Ile Phe Pro Pro Ser 225 230 235 240 Asp Glu Gln Leu Lys Ser Gly
Thr Ala Ser Val Val Cys Leu Leu Asn 245 250 255 Asn Phe Tyr Pro Arg
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 260 265 270 Leu Gln Ser
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 275 280 285 Asp
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 290 295
300 Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu
305 310 315 320 Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
325 330 106344PRTArtificial SequenceH6L1 Heavy chain 106Gln Val Gln
Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25
30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val
35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly
Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Ser Leu Thr Asp
Tyr Tyr Trp Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu
Val Thr Val Asp Asp Asp Asp Lys Leu Val 115 120 125 Gln Pro Gly Gly
Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr 130 135 140 Phe Ser
Ser Tyr Val Met His Trp Leu Arg Gln Ala Pro Gly Lys Gly 145 150 155
160 Leu Glu Trp Val Ser Val Ile Gly Thr Gly Gly Val Thr His Tyr Ala
165 170 175 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
Lys Asn 180 185 190 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val 195 200 205 Tyr Tyr Cys Ala Arg Trp Gly Tyr Tyr Gly
Ser Gly Ser Tyr Glu Asn 210 215 220 Asp Ala Phe Asp Ile Trp Gly Gln
Gly Thr Met Val Thr Val Ser Ser 225 230 235 240 Ala Ser Thr Lys Gly
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 245 250 255 Ser Thr Ser
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 260 265 270 Phe
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 275 280
285 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
290 295 300 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
Gln Thr 305 310 315 320 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn
Thr Lys Val Asp Lys 325 330 335 Lys Val Glu Pro Lys Cys Glu Phe 340
107357PRTArtificial SequenceH1L5a Heavy chain 107Gln Val Gln Leu
Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35
40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser
Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Ala Ala Ala Ala Ala Ala
Ala Ala Ala Ala Ala Ala Ala 100 105 110 Trp Gly Gln Gly Thr Leu Val
Thr Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys Glu Val Gln Leu
Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly 130 135 140 Gly Ser Leu
Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser 145 150 155 160
Tyr Val Met His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 165
170 175 Val Ser Val Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser
Val 180 185 190 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
Ser Leu Tyr 195 200 205 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 210 215 220 Ala Arg Trp Gly Tyr Tyr Gly Ser Gly
Ser Tyr Glu Asn Asp Ala Phe 225 230 235 240 Asp Ile Trp Gly Gln Gly
Thr Met Val Thr Val Ser Ser Ala Ser Thr 245 250 255 Lys Gly Pro
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 260 265 270 Gly
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 275 280
285 Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
290 295 300 Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
Ser Ser 305 310 315 320 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
Gln Thr Tyr Ile Cys 325 330 335 Asn Val Asn His Lys Pro Ser Asn Thr
Lys Val Asp Lys Lys Val Glu 340 345 350 Pro Lys Cys Glu Phe 355
108357PRTArtificial SequenceH1L5a Heavy chain 108Gln Val Gln Leu
Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35
40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser
Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Ala Ala Ala Ala Ala Ala
Ala Ala Ala Ala Ala Ala Ala 100 105 110 Trp Gly Gln Gly Thr Leu Val
Thr Val Ser Ala Ser Asp Asp Asp Asp 115 120 125 Lys Glu Val Gln Leu
Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly 130 135 140 Gly Ser Leu
Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser 145 150 155 160
Tyr Val Met His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 165
170 175 Val Ser Val Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser
Val 180 185 190 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
Ser Leu Tyr 195 200 205 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 210 215 220 Ala Arg Trp Gly Tyr Tyr Gly Ser Gly
Ser Tyr Glu Asn Asp Ala Phe 225 230 235 240 Asp Ile Trp Gly Gln Gly
Thr Met Val Thr Val Ser Ser Ala Ser Thr 245 250 255 Lys Gly Pro Ser
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 260 265 270 Gly Gly
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 275 280 285
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 290
295 300 Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
Ser 305 310 315 320 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
Thr Tyr Ile Cys 325 330 335 Asn Val Asn His Lys Pro Ser Asn Thr Lys
Val Asp Lys Lys Val Glu 340 345 350 Pro Lys Cys Glu Phe 355
109354PRTArtificial SequenceH2L1a Heavy chain 109Gln Val Gln Leu
Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35
40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser
Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Ala Ala Ala Ala Ala Ala
Ala Ala Ala Ala Ala Ala Ala 100 105 110 Trp Gly Gln Gly Thr Leu Val
Thr Val Asp Asp Asp Asp Lys Glu Val 115 120 125 Gln Leu Val Gln Ser
Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 130 135 140 Arg Leu Ser
Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met 145 150 155 160
His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val 165
170 175 Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys Gly
Arg 180 185 190 Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
Leu Gln Met 195 200 205 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr Tyr Gly Ser Gly Ser Tyr Glu
Asn Asp Ala Phe Asp Ile Trp 225 230 235 240 Gly Gln Gly Thr Met Val
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 245 250 255 Ser Val Phe Pro
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 260 265 270 Ala Ala
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 275 280 285
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 290
295 300 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
Thr 305 310 315 320 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
Cys Asn Val Asn 325 330 335 His Lys Pro Ser Asn Thr Lys Val Asp Lys
Lys Val Glu Pro Lys Cys 340 345 350 Glu Phe 110354PRTArtificial
SequenceH2L1a Heavy chain 110Gln Val Gln Leu Val Glu Ser Gly Gly
Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val
Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile
Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70
75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
Cys 85 90 95 Ala Arg Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
Ala Ala Ala 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Asp Asp
Asp Asp Lys Glu Val 115 120 125 Gln Leu Val Gln Ser Gly Gly Gly Leu
Val Gln Pro Gly Gly Ser Leu 130 135 140 Arg Leu Ser Cys Ala Gly Ser
Gly Phe Thr Phe Ser Ser Tyr Val Met 145 150 155 160 His Trp Leu Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val 165 170 175 Ile Gly
Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys Gly Arg 180 185 190
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 195
200 205 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
Trp 210 215 220 Gly Tyr Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala Phe
Asp Ile Trp 225 230 235 240 Gly Gln Gly Thr Met Val Thr Val Ser Ser
Ala Ser Thr Lys Gly Pro 245 250 255 Ser Val Phe Pro Leu Ala Pro Ser
Ser Lys Ser Thr Ser Gly Gly Thr 260 265 270 Ala Ala Leu Gly Cys Leu
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 275 280 285 Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 290 295 300 Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 305 310 315
320 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
325 330 335 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
Lys Cys 340 345 350 Glu Phe 111354PRTArtificial SequenceH2L2a Heavy
chain 111Gln Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro
Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser
Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly
Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly
Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg
Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Asp Asp Asp Asp Lys Glu Val 115
120 125 Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser
Leu 130 135 140 Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser
Tyr Val Met 145 150 155 160 His Trp Leu Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val Ser Val 165 170 175 Ile Gly Thr Gly Gly Val Thr His
Tyr Ala Asp Ser Val Lys Gly Arg 180 185 190 Phe Thr Ile Ser Arg Asp
Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 195 200 205 Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr
Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala Phe Asp Ile Trp 225 230 235
240 Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
245 250 255 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
Gly Thr 260 265 270 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro
Glu Pro Val Thr 275 280 285 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
Gly Val His Thr Phe Pro 290 295 300 Ala Val Leu Gln Ser Ser Gly Leu
Tyr Ser Leu Ser Ser Val Val Thr 305 310 315 320 Val Pro Ser Ser Ser
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 325 330 335 His Lys Pro
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Cys 340 345 350 Glu
Phe 112354PRTArtificial SequenceH2L2a Heavy chain 112Gln Val Gln
Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25
30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val
35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly
Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Ala Ala Ala Ala Ala
Ala Ala Ala Ala Ala Ala Ala Ala 100 105 110 Trp Gly Gln Gly Thr Leu
Val Thr Val Asp Asp Asp Asp Lys Glu Val 115 120 125 Gln Leu Val Gln
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 130 135 140 Arg Leu
Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met 145 150 155
160 His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val
165 170 175 Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys
Gly Arg 180 185 190 Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
Tyr Leu Gln Met 195 200 205 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr Tyr Gly Ser Gly Ser Tyr
Glu Asn Asp Ala Phe Asp Ile Trp 225 230 235 240 Gly Gln Gly Thr Met
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 245 250 255 Ser Val Phe
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 260 265 270 Ala
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 275 280
285 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
290 295 300 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
Val Thr 305 310 315 320 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
Ile Cys Asn Val Asn 325 330 335 His Lys Pro Ser Asn Thr Lys Val Asp
Lys Lys Val Glu Pro Lys Cys 340 345 350 Glu Phe 113354PRTArtificial
SequenceH2L4a Heavy chain 113Gln Val Gln Leu Val Glu Ser Gly Gly
Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val
Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile
Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70
75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
Cys 85 90 95 Ala Arg Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
Ala Ala Ala 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Asp Asp
Asp Asp Lys Glu Val 115 120 125 Gln Leu Val Gln Ser Gly Gly Gly Leu
Val Gln Pro Gly Gly Ser Leu 130 135 140 Arg Leu Ser Cys Ala Gly Ser
Gly Phe Thr Phe Ser Ser Tyr Val Met 145 150 155 160 His Trp Leu Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val 165 170 175 Ile Gly
Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys Gly Arg 180 185 190
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 195
200 205 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
Trp 210 215 220 Gly Tyr Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala Phe
Asp Ile Trp 225 230 235 240 Gly Gln Gly Thr Met Val Thr Val Ser Ser
Ala Ser Thr Lys Gly Pro 245 250 255 Ser Val Phe Pro Leu Ala Pro Ser
Ser Lys Ser Thr Ser Gly Gly Thr 260 265 270 Ala Ala Leu Gly Cys Leu
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 275 280 285 Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 290 295 300 Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 305 310 315
320 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
325 330 335 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
Lys Cys 340 345 350 Glu Phe 114354PRTArtificial SequenceH2L4a Heavy
chain 114Gln Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro
Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser
Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly
Lys Glu Leu Glu Trp
Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala
Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Ala Ala Ala Ala
Ala Ala Ala Ala Ala Ala Ala Ala Ala 100 105 110 Trp Gly Gln Gly Thr
Leu Val Thr Val Asp Asp Asp Asp Lys Glu Val 115 120 125 Gln Leu Val
Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 130 135 140 Arg
Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met 145 150
155 160 His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
Val 165 170 175 Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val
Lys Gly Arg 180 185 190 Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser
Leu Tyr Leu Gln Met 195 200 205 Asn Ser Leu Arg Ala Glu Asp Thr Ala
Val Tyr Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr Tyr Gly Ser Gly Ser
Tyr Glu Asn Asp Ala Phe Asp Ile Trp 225 230 235 240 Gly Gln Gly Thr
Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 245 250 255 Ser Val
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 260 265 270
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 275
280 285 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
Pro 290 295 300 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
Val Val Thr 305 310 315 320 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
Tyr Ile Cys Asn Val Asn 325 330 335 His Lys Pro Ser Asn Thr Lys Val
Asp Lys Lys Val Glu Pro Lys Cys 340 345 350 Glu Phe
115354PRTArtificial SequenceH2L5a Heavy chain 115Gln Val Gln Leu
Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu
Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35
40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser
Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Ala Ala Ala Ala Ala Ala
Ala Ala Ala Ala Ala Ala Ala 100 105 110 Trp Gly Gln Gly Thr Leu Val
Thr Val Asp Asp Asp Asp Lys Glu Val 115 120 125 Gln Leu Val Gln Ser
Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 130 135 140 Arg Leu Ser
Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met 145 150 155 160
His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val 165
170 175 Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys Gly
Arg 180 185 190 Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
Leu Gln Met 195 200 205 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr Tyr Gly Ser Gly Ser Tyr Glu
Asn Asp Ala Phe Asp Ile Trp 225 230 235 240 Gly Gln Gly Thr Met Val
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 245 250 255 Ser Val Phe Pro
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 260 265 270 Ala Ala
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 275 280 285
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 290
295 300 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
Thr 305 310 315 320 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
Cys Asn Val Asn 325 330 335 His Lys Pro Ser Asn Thr Lys Val Asp Lys
Lys Val Glu Pro Lys Cys 340 345 350 Glu Phe 116354PRTArtificial
SequenceH2L5a Heavy chain 116Gln Val Gln Leu Val Glu Ser Gly Gly
Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val
Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile
Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70
75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
Cys 85 90 95 Ala Arg Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
Ala Ala Ala 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Asp Asp
Asp Asp Lys Glu Val 115 120 125 Gln Leu Val Gln Ser Gly Gly Gly Leu
Val Gln Pro Gly Gly Ser Leu 130 135 140 Arg Leu Ser Cys Ala Gly Ser
Gly Phe Thr Phe Ser Ser Tyr Val Met 145 150 155 160 His Trp Leu Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val 165 170 175 Ile Gly
Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys Gly Arg 180 185 190
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 195
200 205 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
Trp 210 215 220 Gly Tyr Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala Phe
Asp Ile Trp 225 230 235 240 Gly Gln Gly Thr Met Val Thr Val Ser Ser
Ala Ser Thr Lys Gly Pro 245 250 255 Ser Val Phe Pro Leu Ala Pro Ser
Ser Lys Ser Thr Ser Gly Gly Thr 260 265 270 Ala Ala Leu Gly Cys Leu
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 275 280 285 Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 290 295 300 Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 305 310 315
320 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
325 330 335 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
Lys Cys 340 345 350 Glu Phe 117354PRTArtificial SequenceH2L7a Heavy
chain 117Gln Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro
Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser
Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly
Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly
Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg
Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Asp Asp Asp Asp Lys Glu Val 115
120 125 Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser
Leu 130 135 140 Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser
Tyr Val Met 145 150 155 160 His Trp Leu Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val Ser Val 165 170 175 Ile Gly Thr Gly Gly Val Thr His
Tyr Ala Asp Ser Val Lys Gly Arg 180 185 190 Phe Thr Ile Ser Arg Asp
Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 195 200 205 Asn Ser Leu Arg
Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr
Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala Phe Asp Ile Trp 225 230 235
240 Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
245 250 255 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
Gly Thr 260 265 270 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro
Glu Pro Val Thr 275 280 285 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
Gly Val His Thr Phe Pro 290 295 300 Ala Val Leu Gln Ser Ser Gly Leu
Tyr Ser Leu Ser Ser Val Val Thr 305 310 315 320 Val Pro Ser Ser Ser
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 325 330 335 His Lys Pro
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Cys 340 345 350 Glu
Phe 118354PRTArtificial SequenceH2L7a Heavy chain 118Gln Val Gln
Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25
30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val
35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly
Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Ala Ala Ala Ala Ala
Ala Ala Ala Ala Ala Ala Ala Ala 100 105 110 Trp Gly Gln Gly Thr Leu
Val Thr Val Asp Asp Asp Asp Lys Glu Val 115 120 125 Gln Leu Val Gln
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 130 135 140 Arg Leu
Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Val Met 145 150 155
160 His Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val
165 170 175 Ile Gly Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys
Gly Arg 180 185 190 Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
Tyr Leu Gln Met 195 200 205 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
Tyr Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr Tyr Gly Ser Gly Ser Tyr
Glu Asn Asp Ala Phe Asp Ile Trp 225 230 235 240 Gly Gln Gly Thr Met
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 245 250 255 Ser Val Phe
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 260 265 270 Ala
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 275 280
285 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
290 295 300 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
Val Thr 305 310 315 320 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
Ile Cys Asn Val Asn 325 330 335 His Lys Pro Ser Asn Thr Lys Val Asp
Lys Lys Val Glu Pro Lys Cys 340 345 350 Glu Phe 119354PRTArtificial
SequenceH2L8a Heavy chain 119Gln Val Gln Leu Val Glu Ser Gly Gly
Thr Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala
Ala Ser Gly Phe Ser Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val
Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile
Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70
75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
Cys 85 90 95 Ala Arg Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
Ala Ala Ala 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Asp Asp
Asp Asp Lys Glu Val 115 120 125 Gln Leu Val Gln Ser Gly Gly Gly Leu
Val Gln Pro Gly Gly Ser Leu 130 135 140 Arg Leu Ser Cys Ala Gly Ser
Gly Phe Thr Phe Ser Ser Tyr Val Met 145 150 155 160 His Trp Leu Arg
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val 165 170 175 Ile Gly
Thr Gly Gly Val Thr His Tyr Ala Asp Ser Val Lys Gly Arg 180 185 190
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 195
200 205 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
Trp 210 215 220 Gly Tyr Tyr Gly Ser Gly Ser Tyr Glu Asn Asp Ala Phe
Asp Ile Trp 225 230 235 240 Gly Gln Gly Thr Met Val Thr Val Ser Ser
Ala Ser Thr Lys Gly Pro 245 250 255 Ser Val Phe Pro Leu Ala Pro Ser
Ser Lys Ser Thr Ser Gly Gly Thr 260 265 270 Ala Ala Leu Gly Cys Leu
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 275 280 285 Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 290 295 300 Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 305 310 315
320 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
325 330 335 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
Lys Cys 340 345 350 Glu Phe 120354PRTArtificial SequenceH2L8a Heavy
chain 120Gln Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro
Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser
Phe Thr Asp Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly
Lys Glu Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly
Ser Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg
Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Asp Asp Asp Asp Lys Glu Val 115
120 125 Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser
Leu 130 135 140 Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser
Tyr Val Met 145 150 155 160 His Trp Leu Arg Gln Ala Pro Gly Lys Gly
Leu Glu Trp Val Ser Val 165 170 175 Ile Gly Thr Gly Gly Val Thr His
Tyr Ala Asp Ser Val Lys Gly Arg 180 185 190 Phe Thr Ile Ser Arg Asp
Asn Ala
Lys Asn Ser Leu Tyr Leu Gln Met 195 200 205 Asn Ser Leu Arg Ala Glu
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp 210 215 220 Gly Tyr Tyr Gly
Ser Gly Ser Tyr Glu Asn Asp Ala Phe Asp Ile Trp 225 230 235 240 Gly
Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 245 250
255 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
260 265 270 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
Val Thr 275 280 285 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
His Thr Phe Pro 290 295 300 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
Leu Ser Ser Val Val Thr 305 310 315 320 Val Pro Ser Ser Ser Leu Gly
Thr Gln Thr Tyr Ile Cys Asn Val Asn 325 330 335 His Lys Pro Ser Asn
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Cys 340 345 350 Glu Phe
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