U.S. patent application number 15/387188 was filed with the patent office on 2017-07-13 for adeno-associated virus serotype i nucleic acid sequences, vectors and host cells containing same. The applicant listed for this patent is The Trustees of the University of Pennsylvania. Invention is credited to James M. Wilson, Weidong Xiao.
Application Number | 20170198304 15/387188 |
Document ID | / |
Family ID | 31996504 |
Filed Date | 2017-07-13 |
United States Patent Application | 20170198304 |
Kind Code | A1 |
Wilson; James M. ; et al. | July 13, 2017 |
The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors.
Inventors: | Wilson; James M.; (Glen Mills, PA) ; Xiao; Weidong; (Fort Washington, PA) | ||||||||||
Applicant: |
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Family ID: | 31996504 | ||||||||||
Appl. No.: | 15/387188 | ||||||||||
Filed: | December 21, 2016 |
Application Number | Filing Date | Patent Number | ||
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14849722 | Sep 10, 2015 | 9567607 | ||
15387188 | ||||
14136331 | Dec 20, 2013 | 9163260 | ||
14849722 | ||||
13048936 | Mar 16, 2011 | 8637255 | ||
14136331 | ||||
12617967 | Nov 13, 2009 | |||
13048936 | ||||
11893697 | Aug 17, 2007 | |||
12617967 | ||||
11708785 | Feb 20, 2007 | |||
11893697 | ||||
10696900 | Oct 30, 2003 | 7186552 | ||
11708785 | ||||
09807802 | Nov 29, 2001 | 6759237 | ||
PCT/US99/25694 | Nov 2, 1999 | |||
10696900 | ||||
11430226 | May 8, 2006 | |||
11893697 | ||||
10696282 | Oct 29, 2003 | 7105345 | ||
11430226 | ||||
09807802 | Nov 29, 2001 | 6759237 | ||
PCT/US99/25694 | Nov 2, 1999 | |||
10696282 | ||||
60107114 | Nov 5, 1998 | |||
60107114 | Nov 5, 1998 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | C12N 2750/14143 20130101; C12N 2750/14121 20130101; C07K 14/8125 20130101; A61K 48/00 20130101; C12N 7/00 20130101; C12N 2750/14122 20130101; C07K 14/505 20130101; C12N 15/86 20130101; C07K 14/005 20130101; C12N 2750/14042 20130101; C12N 2799/025 20130101 |
International Class: | C12N 15/86 20060101 C12N015/86; C07K 14/81 20060101 C07K014/81; C07K 14/005 20060101 C07K014/005 |
Sequence CWU 1
1
2014718DNAAAV-1CDS(335)..(2206) 1ttgcccactc cctctctgcg cgctcgctcg
ctcggtgggg cctgcggacc aaaggtccgc 60agacggcaga gctctgctct gccggcccca
ccgagcgagc gagcgcgcag agagggagtg 120ggcaactcca tcactagggg
taatcgcgaa gcgcctccca cgctgccgcg tcagcgctga 180cgtaaattac
gtcatagggg agtggtcctg tattagctgt cacgtgagtg cttttgcgac
240attttgcgac accacgtggc catttagggt atatatggcc gagtgagcga
gcaggatctc 300cattttgacc gcgaaatttg aacgagcagc agcc atg ccg ggc ttc
tac gag atc 355 Met Pro Gly Phe Tyr Glu Ile 1 5 gtg atc aag gtg ccg
agc gac ctg gac gag cac ctg ccg ggc att tct 403Val Ile Lys Val Pro
Ser Asp Leu Asp Glu His Leu Pro Gly Ile Ser 10 15 20 gac tcg ttt
gtg agc tgg gtg gcc gag aag gaa tgg gag ctg ccc ccg 451Asp Ser Phe
Val Ser Trp Val Ala Glu Lys Glu Trp Glu Leu Pro Pro 25 30 35 gat
tct gac atg gat ctg aat ctg att gag cag gca ccc ctg acc gtg 499Asp
Ser Asp Met Asp Leu Asn Leu Ile Glu Gln Ala Pro Leu Thr Val 40 45
50 55 gcc gag aag ctg cag cgc gac ttc ctg gtc caa tgg cgc cgc gtg
agt 547Ala Glu Lys Leu Gln Arg Asp Phe Leu Val Gln Trp Arg Arg Val
Ser 60 65 70 aag gcc ccg gag gcc ctc ttc ttt gtt cag ttc gag aag
ggc gag tcc 595Lys Ala Pro Glu Ala Leu Phe Phe Val Gln Phe Glu Lys
Gly Glu Ser 75 80 85 tac ttc cac ctc cat att ctg gtg gag acc acg
ggg gtc aaa tcc atg 643Tyr Phe His Leu His Ile Leu Val Glu Thr Thr
Gly Val Lys Ser Met 90 95 100 gtg ctg ggc cgc ttc ctg agt cag att
agg gac aag ctg gtg cag acc 691Val Leu Gly Arg Phe Leu Ser Gln Ile
Arg Asp Lys Leu Val Gln Thr 105 110 115 atc tac cgc ggg atc gag ccg
acc ctg ccc aac tgg ttc gcg gtg acc 739Ile Tyr Arg Gly Ile Glu Pro
Thr Leu Pro Asn Trp Phe Ala Val Thr 120 125 130 135 aag acg cgt aat
ggc gcc gga ggg ggg aac aag gtg gtg gac gag tgc 787Lys Thr Arg Asn
Gly Ala Gly Gly Gly Asn Lys Val Val Asp Glu Cys 140 145 150 tac atc
ccc aac tac ctc ctg ccc aag act cag ccc gag ctg cag tgg 835Tyr Ile
Pro Asn Tyr Leu Leu Pro Lys Thr Gln Pro Glu Leu Gln Trp 155 160 165
gcg tgg act aac atg gag gag tat ata agc gcc tgt ttg aac ctg gcc
883Ala Trp Thr Asn Met Glu Glu Tyr Ile Ser Ala Cys Leu Asn Leu Ala
170 175 180 gag cgc aaa cgg ctc gtg gcg cag cac ctg acc cac gtc agc
cag acc 931Glu Arg Lys Arg Leu Val Ala Gln His Leu Thr His Val Ser
Gln Thr 185 190 195 cag gag cag aac aag gag aat ctg aac ccc aat tct
gac gcg cct gtc 979Gln Glu Gln Asn Lys Glu Asn Leu Asn Pro Asn Ser
Asp Ala Pro Val 200 205 210 215 atc cgg tca aaa acc tcc gcg cgc tac
atg gag ctg gtc ggg tgg ctg 1027Ile Arg Ser Lys Thr Ser Ala Arg Tyr
Met Glu Leu Val Gly Trp Leu 220 225 230 gtg gac cgg ggc atc acc tcc
gag aag cag tgg atc cag gag gac cag 1075Val Asp Arg Gly Ile Thr Ser
Glu Lys Gln Trp Ile Gln Glu Asp Gln 235 240 245 gcc tcg tac atc tcc
ttc aac gcc gct tcc aac tcg cgg tcc cag atc 1123Ala Ser Tyr Ile Ser
Phe Asn Ala Ala Ser Asn Ser Arg Ser Gln Ile 250 255 260 aag gcc gct
ctg gac aat gcc ggc aag atc atg gcg ctg acc aaa tcc 1171Lys Ala Ala
Leu Asp Asn Ala Gly Lys Ile Met Ala Leu Thr Lys Ser 265 270 275 gcg
ccc gac tac ctg gta ggc ccc gct ccg ccc gcg gac att aaa acc 1219Ala
Pro Asp Tyr Leu Val Gly Pro Ala Pro Pro Ala Asp Ile Lys Thr 280 285
290 295 aac cgc atc tac cgc atc ctg gag ctg aac ggc tac gaa cct gcc
tac 1267Asn Arg Ile Tyr Arg Ile Leu Glu Leu Asn Gly Tyr Glu Pro Ala
Tyr 300 305 310 gcc ggc tcc gtc ttt ctc ggc tgg gcc cag aaa agg ttc
ggg aag cgc 1315Ala Gly Ser Val Phe Leu Gly Trp Ala Gln Lys Arg Phe
Gly Lys Arg 315 320 325 aac acc atc tgg ctg ttt ggg ccg gcc acc acg
ggc aag acc aac atc 1363Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr
Gly Lys Thr Asn Ile 330 335 340 gcg gaa gcc atc gcc cac gcc gtg ccc
ttc tac ggc tgc gtc aac tgg 1411Ala Glu Ala Ile Ala His Ala Val Pro
Phe Tyr Gly Cys Val Asn Trp 345 350 355 acc aat gag aac ttt ccc ttc
aat gat tgc gtc gac aag atg gtg atc 1459Thr Asn Glu Asn Phe Pro Phe
Asn Asp Cys Val Asp Lys Met Val Ile 360 365 370 375 tgg tgg gag gag
ggc aag atg acg gcc aag gtc gtg gag tcc gcc aag 1507Trp Trp Glu Glu
Gly Lys Met Thr Ala Lys Val Val Glu Ser Ala Lys 380 385 390 gcc att
ctc ggc ggc agc aag gtg cgc gtg gac caa aag tgc aag tcg 1555Ala Ile
Leu Gly Gly Ser Lys Val Arg Val Asp Gln Lys Cys Lys Ser 395 400 405
tcc gcc cag atc gac ccc acc ccc gtg atc gtc acc tcc aac acc aac
1603Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val Thr Ser Asn Thr Asn
410 415 420 atg tgc gcc gtg att gac ggg aac agc acc acc ttc gag cac
cag cag 1651Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr Phe Glu His
Gln Gln 425 430 435 ccg ttg cag gac cgg atg ttc aaa ttt gaa ctc acc
cgc cgt ctg gag 1699Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu Thr
Arg Arg Leu Glu 440 445 450 455 cat gac ttt ggc aag gtg aca aag cag
gaa gtc aaa gag ttc ttc cgc 1747His Asp Phe Gly Lys Val Thr Lys Gln
Glu Val Lys Glu Phe Phe Arg 460 465 470 tgg gcg cag gat cac gtg acc
gag gtg gcg cat gag ttc tac gtc aga 1795Trp Ala Gln Asp His Val Thr
Glu Val Ala His Glu Phe Tyr Val Arg 475 480 485 aag ggt gga gcc aac
aaa aga ccc gcc ccc gat gac gcg gat aaa agc 1843Lys Gly Gly Ala Asn
Lys Arg Pro Ala Pro Asp Asp Ala Asp Lys Ser 490 495 500 gag ccc aag
cgg gcc tgc ccc tca gtc gcg gat cca tcg acg tca gac 1891Glu Pro Lys
Arg Ala Cys Pro Ser Val Ala Asp Pro Ser Thr Ser Asp 505 510 515 gcg
gaa gga gct ccg gtg gac ttt gcc gac agg tac caa aac aaa tgt 1939Ala
Glu Gly Ala Pro Val Asp Phe Ala Asp Arg Tyr Gln Asn Lys Cys 520 525
530 535 tct cgt cac gcg ggc atg ctt cag atg ctg ttt ccc tgc aag aca
tgc 1987Ser Arg His Ala Gly Met Leu Gln Met Leu Phe Pro Cys Lys Thr
Cys 540 545 550 gag aga atg aat cag aat ttc aac att tgc ttc acg cac
ggg acg aga 2035Glu Arg Met Asn Gln Asn Phe Asn Ile Cys Phe Thr His
Gly Thr Arg 555 560 565 gac tgt tca gag tgc ttc ccc ggc gtg tca gaa
tct caa ccg gtc gtc 2083Asp Cys Ser Glu Cys Phe Pro Gly Val Ser Glu
Ser Gln Pro Val Val 570 575 580 aga aag agg acg tat cgg aaa ctc tgt
gcc att cat cat ctg ctg ggg 2131Arg Lys Arg Thr Tyr Arg Lys Leu Cys
Ala Ile His His Leu Leu Gly 585 590 595 cgg gct ccc gag att gct tgc
tcg gcc tgc gat ctg gtc aac gtg gac 2179Arg Ala Pro Glu Ile Ala Cys
Ser Ala Cys Asp Leu Val Asn Val Asp 600 605 610 615 ctg gat gac tgt
gtt tct gag caa taa atgacttaaa ccaggt atg gct gcc 2231Leu Asp Asp
Cys Val Ser Glu Gln Met Ala Ala 620 625 gat ggt tat ctt cca gat tgg
ctc gag gac aac ctc tct gag ggc att 2279Asp Gly Tyr Leu Pro Asp Trp
Leu Glu Asp Asn Leu Ser Glu Gly Ile 630 635 640 cgc gag tgg tgg gac
ttg aaa cct gga gcc ccg aag ccc aaa gcc aac 2327Arg Glu Trp Trp Asp
Leu Lys Pro Gly Ala Pro Lys Pro Lys Ala Asn 645 650 655 cag caa aag
cag gac gac ggc cgg ggt ctg gtg ctt cct ggc tac aag 2375Gln Gln Lys
Gln Asp Asp Gly Arg Gly Leu Val Leu Pro Gly Tyr Lys 660 665 670 tac
ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc gtc aac gcg 2423Tyr
Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Ala 675 680
685 690 gcg gac gca gcg gcc ctc gag cac gac aag gcc tac gac cag cag
ctc 2471Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln Gln
Leu 695 700 705 aaa gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc
gac gcc gag 2519Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala
Asp Ala Glu 710 715 720 ttt cag gag cgt ctg caa gaa gat acg tct ttt
ggg ggc aac ctc ggg 2567Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe
Gly Gly Asn Leu Gly 725 730 735 cga gca gtc ttc cag gcc aag aag cgg
gtt ctc gaa cct ctc ggt ctg 2615Arg Ala Val Phe Gln Ala Lys Lys Arg
Val Leu Glu Pro Leu Gly Leu 740 745 750 gtt gag gaa ggc gct aag acg
gct cct gga aag aaa cgt ccg gta gag 2663Val Glu Glu Gly Ala Lys Thr
Ala Pro Gly Lys Lys Arg Pro Val Glu 755 760 765 770 cag tcg cca caa
gag cca gac tcc tcc tcg ggc atc ggc aag aca ggc 2711Gln Ser Pro Gln
Glu Pro Asp Ser Ser Ser Gly Ile Gly Lys Thr Gly 775 780 785 cag cag
ccc gct aaa aag aga ctc aat ttt ggt cag act ggc gac tca 2759Gln Gln
Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser 790 795 800
gag tca gtc ccc gat cca caa cct ctc gga gaa cct cca gca acc ccc
2807Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala Thr Pro
805 810 815 gct gct gtg gga cct act aca atg gct tca ggc ggt ggc gca
cca atg 2855Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly Ala
Pro Met 820 825 830 gca gac aat aac gaa ggc gcc gac gga gtg ggt aat
gcc tca gga aat 2903Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn
Ala Ser Gly Asn 835 840 845 850 tgg cat tgc gat tcc aca tgg ctg ggc
gac aga gtc atc acc acc agc 2951Trp His Cys Asp Ser Thr Trp Leu Gly
Asp Arg Val Ile Thr Thr Ser 855 860 865 acc cgc acc tgg gcc ttg ccc
acc tac aat aac cac ctc tac aag caa 2999Thr Arg Thr Trp Ala Leu Pro
Thr Tyr Asn Asn His Leu Tyr Lys Gln 870 875 880 atc tcc agt gct tca
acg ggg gcc agc aac gac aac cac tac ttc ggc 3047Ile Ser Ser Ala Ser
Thr Gly Ala Ser Asn Asp Asn His Tyr Phe Gly 885 890 895 tac agc acc
ccc tgg ggg tat ttt gat ttc aac aga ttc cac tgc cac 3095Tyr Ser Thr
Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His 900 905 910 ttt
tca cca cgt gac tgg cag cga ctc atc aac aac aat tgg gga ttc 3143Phe
Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe 915 920
925 930 cgg ccc aag aga ctc aac ttc aaa ctc ttc aac atc caa gtc aag
gag 3191Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys
Glu 935 940 945 gtc acg acg aat gat ggc gtc aca acc atc gct aat aac
ctt acc agc 3239Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn
Leu Thr Ser 950 955 960 acg gtt caa gtc ttc tcg gac tcg gag tac cag
ctt ccg tac gtc ctc 3287Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln
Leu Pro Tyr Val Leu 965 970 975 ggc tct gcg cac cag ggc tgc ctc cct
ccg ttc ccg gcg gac gtg ttc 3335Gly Ser Ala His Gln Gly Cys Leu Pro
Pro Phe Pro Ala Asp Val Phe 980 985 990 atg att ccg caa tac ggc tac
ctg acg ctc aac aat ggc agc caa 3380Met Ile Pro Gln Tyr Gly Tyr Leu
Thr Leu Asn Asn Gly Ser Gln 995 1000 1005 gcc gtg gga cgt tca tcc
ttt tac tgc ctg gaa tat ttc cct tct 3425Ala Val Gly Arg Ser Ser Phe
Tyr Cys Leu Glu Tyr Phe Pro Ser 1010 1015 1020 cag atg ctg aga acg
ggc aac aac ttt acc ttc agc tac acc ttt 3470Gln Met Leu Arg Thr Gly
Asn Asn Phe Thr Phe Ser Tyr Thr Phe 1025 1030 1035 gag gaa gtg cct
ttc cac agc agc tac gcg cac agc cag agc ctg 3515Glu Glu Val Pro Phe
His Ser Ser Tyr Ala His Ser Gln Ser Leu 1040 1045 1050 gac cgg ctg
atg aat cct ctc atc gac caa tac ctg tat tac ctg 3560Asp Arg Leu Met
Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 1055 1060 1065 aac aga
act caa aat cag tcc gga agt gcc caa aac aag gac ttg 3605Asn Arg Thr
Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu 1070 1075 1080 ctg
ttt agc cgt ggg tct cca gct ggc atg tct gtt cag ccc aaa 3650Leu Phe
Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys 1085 1090 1095
aac tgg cta cct gga ccc tgt tat cgg cag cag cgc gtt tct aaa 3695Asn
Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys 1100 1105
1110 aca aaa aca gac aac aac aac agc aat ttt acc tgg act ggt gct
3740Thr Lys Thr Asp Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala
1115 1120 1125 tca aaa tat aac ctc aat ggg cgt gaa tcc atc atc aac
cct ggc 3785Ser Lys Tyr Asn Leu Asn Gly Arg Glu Ser Ile Ile Asn Pro
Gly 1130 1135 1140 act gct atg gcc tca cac aaa gac gac gaa gac aag
ttc ttt ccc 3830Thr Ala Met Ala Ser His Lys Asp Asp Glu Asp Lys Phe
Phe Pro 1145 1150 1155 atg agc ggt gtc atg att ttt gga aaa gag agc
gcc gga gct tca 3875Met Ser Gly Val Met Ile Phe Gly Lys Glu Ser Ala
Gly Ala Ser 1160 1165 1170 aac act gca ttg gac aat gtc atg att aca
gac gaa gag gaa att 3920Asn Thr Ala Leu Asp Asn Val Met Ile Thr Asp
Glu Glu Glu Ile 1175 1180 1185 aaa gcc act aac cct gtg gcc acc gaa
aga ttt ggg acc gtg gca 3965Lys Ala Thr Asn Pro Val Ala Thr Glu Arg
Phe Gly Thr Val Ala 1190 1195 1200 gtc aat ttc cag agc agc agc aca
gac cct gcg acc gga gat gtg 4010Val Asn Phe Gln Ser Ser Ser Thr Asp
Pro Ala Thr Gly Asp Val 1205 1210 1215 cat gct atg gga gca tta cct
ggc atg gtg tgg caa gat aga gac 4055His Ala Met Gly Ala Leu Pro Gly
Met Val Trp Gln Asp Arg Asp 1220 1225 1230 gtg tac ctg cag ggt ccc
att tgg gcc aaa att cct cac aca gat 4100Val Tyr Leu Gln Gly Pro Ile
Trp Ala Lys Ile Pro His Thr Asp 1235 1240 1245 gga cac ttt cac ccg
tct cct ctt atg ggc ggc ttt gga ctc aag 4145Gly His Phe His Pro Ser
Pro Leu Met Gly Gly Phe Gly Leu Lys 1250 1255 1260 aac ccg cct cct
cag atc ctc atc aaa aac acg cct gtt cct gcg 4190Asn Pro Pro Pro Gln
Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 1265 1270 1275
aat cct ccg gcg gag ttt tca gct aca aag ttt gct tca ttc atc 4235Asn
Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile 1280 1285
1290 acc caa tac tcc aca gga caa gtg agt gtg gaa att gaa tgg gag
4280Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu
1295 1300 1305 ctg cag aaa gaa aac agc aag cgc tgg aat ccc gaa gtg
cag tac 4325Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln
Tyr 1310 1315 1320 aca tcc aat tat gca aaa tct gcc aac gtt gat ttt
act gtg gac 4370Thr Ser Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr
Val Asp 1325 1330 1335 aac aat gga ctt tat act gag cct cgc ccc att
ggc acc cgt tac 4415Asn Asn Gly Leu Tyr Thr Glu Pro Arg Pro Ile Gly
Thr Arg Tyr 1340 1345 1350 ctt acc cgt ccc ctg taattacgtg
ttaatcaata aaccggttga ttcgtttcag 4470Leu Thr Arg Pro Leu 1355
ttgaactttg gtctcctgtc cttcttatct tatcggttac catggttata gcttacacat
4530taactgcttg gttgcgcttc gcgataaaag acttacgtca tcgggttacc
cctagtgatg 4590gagttgccca ctccctctct gcgcgctcgc tcgctcggtg
gggcctgcgg accaaaggtc 4650cgcagacggc agagctctgc tctgccggcc
ccaccgagcg agcgagcgcg cagagaggga 4710gtgggcaa 47182623PRTAAV-1 2Met
Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 1 5 10
15 Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Ser Trp Val Ala Glu
20 25 30 Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn
Leu Ile 35 40 45 Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln
Arg Asp Phe Leu 50 55 60 Val Gln Trp Arg Arg Val Ser Lys Ala Pro
Glu Ala Leu Phe Phe Val 65 70 75 80 Gln Phe Glu Lys Gly Glu Ser Tyr
Phe His Leu His Ile Leu Val Glu 85 90 95 Thr Thr Gly Val Lys Ser
Met Val Leu Gly Arg Phe Leu Ser Gln Ile 100 105 110 Arg Asp Lys Leu
Val Gln Thr Ile Tyr Arg Gly Ile Glu Pro Thr Leu 115 120 125 Pro Asn
Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 130 135 140
Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 145
150 155 160 Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Glu
Tyr Ile 165 170 175 Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu
Val Ala Gln His 180 185 190 Leu Thr His Val Ser Gln Thr Gln Glu Gln
Asn Lys Glu Asn Leu Asn 195 200 205 Pro Asn Ser Asp Ala Pro Val Ile
Arg Ser Lys Thr Ser Ala Arg Tyr 210 215 220 Met Glu Leu Val Gly Trp
Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 225 230 235 240 Gln Trp Ile
Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 245 250 255 Ser
Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 260 265
270 Ile Met Ala Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ala
275 280 285 Pro Pro Ala Asp Ile Lys Thr Asn Arg Ile Tyr Arg Ile Leu
Glu Leu 290 295 300 Asn Gly Tyr Glu Pro Ala Tyr Ala Gly Ser Val Phe
Leu Gly Trp Ala 305 310 315 320 Gln Lys Arg Phe Gly Lys Arg Asn Thr
Ile Trp Leu Phe Gly Pro Ala 325 330 335 Thr Thr Gly Lys Thr Asn Ile
Ala Glu Ala Ile Ala His Ala Val Pro 340 345 350 Phe Tyr Gly Cys Val
Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 355 360 365 Cys Val Asp
Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 370 375 380 Lys
Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 385 390
395 400 Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro
Val 405 410 415 Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp
Gly Asn Ser 420 425 430 Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp
Arg Met Phe Lys Phe 435 440 445 Glu Leu Thr Arg Arg Leu Glu His Asp
Phe Gly Lys Val Thr Lys Gln 450 455 460 Glu Val Lys Glu Phe Phe Arg
Trp Ala Gln Asp His Val Thr Glu Val 465 470 475 480 Ala His Glu Phe
Tyr Val Arg Lys Gly Gly Ala Asn Lys Arg Pro Ala 485 490 495 Pro Asp
Asp Ala Asp Lys Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 500 505 510
Ala Asp Pro Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 515
520 525 Asp Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met Leu Gln
Met 530 535 540 Leu Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Asn
Phe Asn Ile 545 550 555 560 Cys Phe Thr His Gly Thr Arg Asp Cys Ser
Glu Cys Phe Pro Gly Val 565 570 575 Ser Glu Ser Gln Pro Val Val Arg
Lys Arg Thr Tyr Arg Lys Leu Cys 580 585 590 Ala Ile His His Leu Leu
Gly Arg Ala Pro Glu Ile Ala Cys Ser Ala 595 600 605 Cys Asp Leu Val
Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 610 615 620
3736PRTAAV-1 3Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp
Asn Leu Ser 1 5 10 15 Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro
Gly Ala Pro Lys Pro 20 25 30 Lys Ala Asn Gln Gln Lys Gln Asp Asp
Gly Arg Gly Leu Val Leu Pro 35 40 45 Gly Tyr Lys Tyr Leu Gly Pro
Phe Asn Gly Leu Asp Lys Gly Glu Pro 50 55 60 Val Asn Ala Ala Asp
Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 65 70 75 80 Gln Gln Leu
Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 85 90 95 Asp
Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 100 105
110 Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro
115 120 125 Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys
Lys Arg 130 135 140 Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser
Ser Gly Ile Gly 145 150 155 160 Lys Thr Gly Gln Gln Pro Ala Lys Lys
Arg Leu Asn Phe Gly Gln Thr 165 170 175 Gly Asp Ser Glu Ser Val Pro
Asp Pro Gln Pro Leu Gly Glu Pro Pro 180 185 190 Ala Thr Pro Ala Ala
Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 195 200 205 Ala Pro Met
Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 210 215 220 Ser
Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 225 230
235 240 Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His
Leu 245 250 255 Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn
Asp Asn His 260 265 270 Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe
Asp Phe Asn Arg Phe 275 280 285 His Cys His Phe Ser Pro Arg Asp Trp
Gln Arg Leu Ile Asn Asn Asn 290 295 300 Trp Gly Phe Arg Pro Lys Arg
Leu Asn Phe Lys Leu Phe Asn Ile Gln 305 310 315 320 Val Lys Glu Val
Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 325 330 335 Leu Thr
Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 340 345 350
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 355
360 365 Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn
Gly 370 375 380 Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu
Tyr Phe Pro 385 390 395 400 Ser Gln Met Leu Arg Thr Gly Asn Asn Phe
Thr Phe Ser Tyr Thr Phe 405 410 415 Glu Glu Val Pro Phe His Ser Ser
Tyr Ala His Ser Gln Ser Leu Asp 420 425 430 Arg Leu Met Asn Pro Leu
Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 435 440 445 Thr Gln Asn Gln
Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 450 455 460 Arg Gly
Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 465 470 475
480 Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn
485 490 495 Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn
Leu Asn 500 505 510 Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met
Ala Ser His Lys 515 520 525 Asp Asp Glu Asp Lys Phe Phe Pro Met Ser
Gly Val Met Ile Phe Gly 530 535 540 Lys Glu Ser Ala Gly Ala Ser Asn
Thr Ala Leu Asp Asn Val Met Ile 545 550 555 560 Thr Asp Glu Glu Glu
Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 565 570 575 Phe Gly Thr
Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 580 585 590 Thr
Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 595 600
605 Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His
610 615 620 Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe
Gly Leu 625 630 635 640 Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn
Thr Pro Val Pro Ala 645 650 655 Asn Pro Pro Ala Glu Phe Ser Ala Thr
Lys Phe Ala Ser Phe Ile Thr 660 665 670 Gln Tyr Ser Thr Gly Gln Val
Ser Val Glu Ile Glu Trp Glu Leu Gln 675 680 685 Lys Glu Asn Ser Lys
Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 690 695 700 Tyr Ala Lys
Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 705 710 715 720
Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725
730 735 41872DNAAAV-1CDS(1)..(1869) 4atg ccg ggc ttc tac gag atc
gtg atc aag gtg ccg agc gac ctg gac 48Met Pro Gly Phe Tyr Glu Ile
Val Ile Lys Val Pro Ser Asp Leu Asp 1 5 10 15 gag cac ctg ccg ggc
att tct gac tcg ttt gtg agc tgg gtg gcc gag 96Glu His Leu Pro Gly
Ile Ser Asp Ser Phe Val Ser Trp Val Ala Glu 20 25 30 aag gaa tgg
gag ctg ccc ccg gat tct gac atg gat ctg aat ctg att 144Lys Glu Trp
Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 35 40 45 gag
cag gca ccc ctg acc gtg gcc gag aag ctg cag cgc gac ttc ctg 192Glu
Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 50 55
60 gtc caa tgg cgc cgc gtg agt aag gcc ccg gag gcc ctc ttc ttt gtt
240Val Gln Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val
65 70 75 80 cag ttc gag aag ggc gag tcc tac ttc cac ctc cat att ctg
gtg gag 288Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Leu His Ile Leu
Val Glu 85 90 95 acc acg ggg gtc aaa tcc atg gtg ctg ggc cgc ttc
ctg agt cag att 336Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe
Leu Ser Gln Ile 100 105 110 agg gac aag ctg gtg cag acc atc tac cgc
ggg atc gag ccg acc ctg 384Arg Asp Lys Leu Val Gln Thr Ile Tyr Arg
Gly Ile Glu Pro Thr Leu 115 120 125 ccc aac tgg ttc gcg gtg acc aag
acg cgt aat ggc gcc gga ggg ggg 432Pro Asn Trp Phe Ala Val Thr Lys
Thr Arg Asn Gly Ala Gly Gly Gly 130 135 140 aac aag gtg gtg gac gag
tgc tac atc ccc aac tac ctc ctg ccc aag 480Asn Lys Val Val Asp Glu
Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 145 150 155 160 act cag ccc
gag ctg cag tgg gcg tgg act aac atg gag gag tat ata 528Thr Gln Pro
Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Glu Tyr Ile 165 170 175 agc
gcc tgt ttg aac ctg gcc gag cgc aaa cgg ctc gtg gcg cag cac 576Ser
Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 180 185
190 ctg acc cac gtc agc cag acc cag gag cag aac aag gag aat ctg aac
624Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Leu Asn
195 200 205 ccc aat tct gac gcg cct gtc atc cgg tca aaa acc tcc gcg
cgc tac 672Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala
Arg Tyr 210 215 220 atg gag ctg gtc ggg tgg ctg gtg gac cgg ggc atc
acc tcc gag aag 720Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile
Thr Ser Glu Lys 225 230 235 240 cag tgg atc cag gag gac cag gcc tcg
tac atc tcc ttc aac gcc gct 768Gln Trp Ile Gln Glu Asp Gln Ala Ser
Tyr Ile Ser Phe Asn Ala Ala 245 250 255 tcc aac tcg cgg tcc cag atc
aag gcc gct ctg gac aat gcc ggc aag 816Ser Asn Ser Arg Ser Gln Ile
Lys Ala Ala Leu Asp Asn Ala Gly Lys 260 265 270 atc atg gcg ctg acc
aaa tcc gcg ccc gac tac ctg gta ggc ccc gct 864Ile Met Ala Leu Thr
Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ala 275 280 285 ccg ccc gcg
gac att aaa acc aac cgc atc tac cgc atc ctg gag ctg 912Pro Pro Ala
Asp Ile Lys Thr Asn Arg Ile Tyr Arg Ile Leu Glu Leu 290 295 300 aac
ggc tac gaa cct gcc tac gcc ggc tcc gtc ttt ctc ggc tgg gcc 960Asn
Gly Tyr Glu Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp Ala 305 310
315 320 cag aaa agg ttc ggg aag cgc aac acc atc tgg ctg ttt ggg ccg
gcc 1008Gln Lys Arg Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro
Ala 325 330 335 acc acg ggc aag acc aac atc gcg gaa gcc atc gcc cac
gcc gtg ccc 1056Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His
Ala Val Pro 340 345 350 ttc tac ggc tgc gtc aac tgg acc aat gag aac
ttt ccc ttc aat gat 1104Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn
Phe Pro Phe Asn Asp 355 360 365 tgc gtc gac aag atg gtg atc tgg tgg
gag gag ggc aag atg acg gcc 1152Cys Val Asp Lys Met Val Ile Trp Trp
Glu Glu Gly Lys Met Thr Ala 370 375 380 aag gtc gtg gag tcc gcc aag
gcc att ctc ggc ggc agc aag gtg cgc 1200Lys Val Val Glu Ser Ala Lys
Ala Ile Leu Gly Gly Ser Lys Val Arg 385 390 395 400 gtg gac caa aag
tgc aag tcg tcc gcc cag atc gac ccc acc ccc gtg 1248Val Asp Gln Lys
Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 405 410 415 atc gtc
acc tcc aac acc aac atg tgc gcc gtg att gac ggg aac agc 1296Ile Val
Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser
420 425 430 acc acc ttc gag cac cag cag ccg ttg cag gac cgg atg ttc
aaa ttt 1344Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe
Lys Phe 435 440 445 gaa ctc acc cgc cgt ctg gag cat gac ttt ggc aag
gtg aca aag cag 1392Glu Leu Thr Arg Arg Leu Glu His Asp Phe Gly Lys
Val Thr Lys Gln 450 455 460 gaa gtc aaa gag ttc ttc cgc tgg gcg cag
gat cac gtg acc gag gtg 1440Glu Val Lys Glu Phe Phe Arg Trp Ala Gln
Asp His Val Thr Glu Val 465 470 475 480 gcg cat gag ttc tac gtc aga
aag ggt gga gcc aac aaa aga ccc gcc 1488Ala His Glu Phe Tyr Val Arg
Lys Gly Gly Ala Asn Lys Arg Pro Ala 485 490 495 ccc gat gac gcg gat
aaa agc gag ccc aag cgg gcc tgc ccc tca gtc 1536Pro Asp Asp Ala Asp
Lys Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 500 505 510 gcg gat cca
tcg acg tca gac gcg gaa gga gct ccg gtg gac ttt gcc 1584Ala Asp Pro
Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 515 520 525 gac
agg tac caa aac aaa tgt tct cgt cac gcg ggc atg ctt cag atg 1632Asp
Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met Leu Gln Met 530 535
540 ctg ttt ccc tgc aag aca tgc gag aga atg aat cag aat ttc aac att
1680Leu Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Asn Phe Asn Ile
545 550 555 560 tgc ttc acg cac ggg acg aga gac tgt tca gag tgc ttc
ccc ggc gtg 1728Cys Phe Thr His Gly Thr Arg Asp Cys Ser Glu Cys Phe
Pro Gly Val 565 570 575 tca gaa tct caa ccg gtc gtc aga aag agg acg
tat cgg aaa ctc tgt 1776Ser Glu Ser Gln Pro Val Val Arg Lys Arg Thr
Tyr Arg Lys Leu Cys 580 585 590 gcc att cat cat ctg ctg ggg cgg gct
ccc gag att gct tgc tcg gcc 1824Ala Ile His His Leu Leu Gly Arg Ala
Pro Glu Ile Ala Cys Ser Ala 595 600 605 tgc gat ctg gtc aac gtg gac
ctg gat gac tgt gtt tct gag caa taa 1872Cys Asp Leu Val Asn Val Asp
Leu Asp Asp Cys Val Ser Glu Gln 610 615 620 5623PRTAAV-1 5Met Pro
Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 1 5 10 15
Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Ser Trp Val Ala Glu 20
25 30 Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu
Ile 35 40 45 Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg
Asp Phe Leu 50 55 60 Val Gln Trp Arg Arg Val Ser Lys Ala Pro Glu
Ala Leu Phe Phe Val 65 70 75 80 Gln Phe Glu Lys Gly Glu Ser Tyr Phe
His Leu His Ile Leu Val Glu 85 90 95 Thr Thr Gly Val Lys Ser Met
Val Leu Gly Arg Phe Leu Ser Gln Ile 100 105 110 Arg Asp Lys Leu Val
Gln Thr Ile Tyr Arg Gly Ile Glu Pro Thr Leu 115 120 125 Pro Asn Trp
Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 130 135 140 Asn
Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 145 150
155 160 Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Glu Tyr
Ile 165 170 175 Ser Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val
Ala Gln His 180 185 190 Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn
Lys Glu Asn Leu Asn 195 200 205 Pro Asn Ser Asp Ala Pro Val Ile Arg
Ser Lys Thr Ser Ala Arg Tyr 210 215 220 Met Glu Leu Val Gly Trp Leu
Val Asp Arg Gly Ile Thr Ser Glu Lys 225 230 235 240 Gln Trp Ile Gln
Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 245 250 255 Ser Asn
Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 260 265 270
Ile Met Ala Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ala 275
280 285 Pro Pro Ala Asp Ile Lys Thr Asn Arg Ile Tyr Arg Ile Leu Glu
Leu 290 295 300 Asn Gly Tyr Glu Pro Ala Tyr Ala Gly Ser Val Phe Leu
Gly Trp Ala 305 310 315 320 Gln Lys Arg Phe Gly Lys Arg Asn Thr Ile
Trp Leu Phe Gly Pro Ala 325 330 335 Thr Thr Gly Lys Thr Asn Ile Ala
Glu Ala Ile Ala His Ala Val Pro 340 345 350 Phe Tyr Gly Cys Val Asn
Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 355 360 365 Cys Val Asp Lys
Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 370 375 380 Lys Val
Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 385 390 395
400 Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val
405 410 415 Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly
Asn Ser 420 425 430 Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg
Met Phe Lys Phe 435 440 445 Glu Leu Thr Arg Arg Leu Glu His Asp Phe
Gly Lys Val Thr Lys Gln 450 455 460 Glu Val Lys Glu Phe Phe Arg Trp
Ala Gln Asp His Val Thr Glu Val 465 470 475 480 Ala His Glu Phe Tyr
Val Arg Lys Gly Gly Ala Asn Lys Arg Pro Ala 485 490 495 Pro Asp Asp
Ala Asp Lys Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 500 505 510 Ala
Asp Pro Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 515 520
525 Asp Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met Leu Gln Met
530 535 540 Leu Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Asn Phe
Asn Ile 545 550 555 560 Cys Phe Thr His Gly Thr Arg Asp Cys Ser Glu
Cys Phe Pro Gly Val 565 570 575 Ser Glu Ser Gln Pro Val Val Arg Lys
Arg Thr Tyr Arg Lys Leu Cys 580 585 590 Ala Ile His His Leu Leu Gly
Arg Ala Pro Glu Ile Ala Cys Ser Ala 595 600 605 Cys Asp Leu Val Asn
Val Asp Leu Asp Asp Cys Val Ser Glu Gln 610 615 620
61641DNAAAV-1CDS(1)..(1638) 6atg ccg ggc ttc tac gag atc gtg atc
aag gtg ccg agc gac ctg gac 48Met Pro Gly Phe Tyr Glu Ile Val Ile
Lys Val Pro Ser Asp Leu Asp 1 5 10 15 gag cac ctg ccg ggc att tct
gac tcg ttt gtg agc tgg gtg gcc gag 96Glu His Leu Pro Gly Ile Ser
Asp Ser Phe Val Ser Trp Val Ala Glu 20 25 30 aag gaa tgg gag ctg
ccc ccg gat tct gac atg gat ctg aat ctg att 144Lys Glu Trp Glu Leu
Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 35 40 45 gag cag gca
ccc ctg acc gtg gcc gag aag ctg cag cgc gac ttc ctg 192Glu Gln Ala
Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 50 55 60 gtc
caa tgg cgc cgc gtg agt aag gcc ccg gag gcc ctc ttc ttt gtt 240Val
Gln Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 65 70
75 80 cag ttc gag aag ggc gag tcc tac ttc cac ctc cat att ctg gtg
gag 288Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Leu His Ile Leu Val
Glu 85 90 95 acc acg ggg gtc aaa tcc atg gtg ctg ggc cgc ttc ctg
agt cag att 336Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu
Ser Gln Ile 100 105 110 agg gac aag ctg gtg cag acc atc tac cgc ggg
atc gag ccg acc ctg 384Arg Asp Lys Leu Val Gln Thr Ile Tyr Arg Gly
Ile Glu Pro Thr Leu 115 120 125 ccc aac tgg ttc gcg gtg acc aag acg
cgt aat ggc gcc gga ggg ggg 432Pro Asn Trp Phe Ala Val Thr Lys Thr
Arg Asn Gly Ala Gly Gly Gly 130 135 140 aac aag gtg gtg gac gag tgc
tac atc ccc aac tac ctc ctg ccc aag 480Asn Lys Val Val Asp Glu Cys
Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 145 150 155 160 act cag ccc gag
ctg cag tgg gcg tgg act aac atg gag gag tat ata 528Thr Gln Pro Glu
Leu Gln Trp Ala Trp Thr Asn Met Glu Glu Tyr Ile 165 170 175 agc gcc
tgt ttg aac ctg gcc gag cgc aaa cgg ctc gtg gcg cag cac 576Ser Ala
Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 180 185 190
ctg acc cac gtc agc cag acc cag gag cag aac aag gag aat ctg aac
624Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Leu Asn
195 200 205 ccc aat tct gac gcg cct gtc atc cgg tca aaa acc tcc gcg
cgc tac 672Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala
Arg Tyr 210 215 220 atg gag ctg gtc ggg tgg ctg gtg gac cgg ggc atc
acc tcc gag aag 720Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile
Thr Ser Glu Lys 225 230 235 240 cag tgg atc cag gag gac cag gcc tcg
tac atc tcc ttc aac gcc gct 768Gln Trp Ile Gln Glu Asp Gln Ala Ser
Tyr Ile Ser Phe Asn Ala Ala 245 250 255 tcc aac tcg cgg tcc cag atc
aag gcc gct ctg gac aat gcc ggc aag 816Ser Asn Ser Arg Ser Gln Ile
Lys Ala Ala Leu Asp Asn Ala Gly Lys 260 265 270 atc atg gcg ctg acc
aaa tcc gcg ccc gac tac ctg gta ggc ccc gct 864Ile Met Ala Leu Thr
Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ala 275 280 285 ccg ccc gcg
gac att aaa acc aac cgc atc tac cgc atc ctg gag ctg 912Pro Pro Ala
Asp Ile Lys Thr Asn Arg Ile Tyr Arg Ile Leu Glu Leu 290 295 300 aac
ggc tac gaa cct gcc tac gcc ggc tcc gtc ttt ctc ggc tgg gcc 960Asn
Gly Tyr Glu Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp Ala 305 310
315 320 cag aaa agg ttc ggg aag cgc aac acc atc tgg ctg ttt ggg ccg
gcc 1008Gln Lys Arg Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro
Ala 325 330 335 acc acg ggc aag acc aac atc gcg gaa gcc atc gcc cac
gcc gtg ccc 1056Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His
Ala Val Pro 340 345 350 ttc tac ggc tgc gtc aac tgg acc aat gag aac
ttt ccc ttc aat gat 1104Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn
Phe Pro Phe Asn Asp 355 360 365 tgc gtc gac aag atg gtg atc tgg tgg
gag gag ggc aag atg acg gcc 1152Cys Val Asp Lys Met Val Ile Trp Trp
Glu Glu Gly Lys Met Thr Ala 370 375 380 aag gtc gtg gag tcc gcc aag
gcc att ctc ggc ggc agc aag gtg cgc 1200Lys Val Val Glu Ser Ala Lys
Ala Ile Leu Gly Gly Ser Lys Val Arg 385 390 395 400 gtg gac caa aag
tgc aag tcg tcc gcc cag atc gac ccc acc ccc gtg 1248Val Asp Gln Lys
Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 405 410 415 atc gtc
acc tcc aac acc aac atg tgc gcc gtg att gac ggg aac agc 1296Ile Val
Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 420 425 430
acc acc ttc gag cac cag cag ccg ttg cag gac cgg atg ttc aaa ttt
1344Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe
435 440 445 gaa ctc acc cgc cgt ctg gag cat gac ttt ggc aag gtg aca
aag cag 1392Glu Leu Thr Arg Arg Leu Glu His Asp Phe Gly Lys Val Thr
Lys Gln 450 455 460 gaa gtc aaa gag ttc ttc cgc tgg gcg cag gat cac
gtg acc gag gtg 1440Glu Val Lys Glu Phe Phe Arg Trp Ala Gln Asp His
Val Thr Glu Val 465 470 475 480 gcg cat gag ttc tac gtc aga aag ggt
gga gcc aac aaa aga ccc gcc 1488Ala His Glu Phe Tyr Val Arg Lys Gly
Gly Ala Asn Lys Arg Pro Ala 485 490 495 ccc gat gac gcg gat aaa agc
gag ccc aag cgg gcc tgc ccc tca gtc 1536Pro Asp Asp Ala Asp Lys Ser
Glu Pro Lys Arg Ala Cys Pro Ser Val 500 505 510 gcg gat cca tcg acg
tca gac gcg gaa gga gct ccg gtg gac ttt gcc 1584Ala Asp Pro Ser Thr
Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 515 520 525 gac agg tat
ggc tgc cga tgg tta tct tcc aga ttg gct cga gga caa 1632Asp Arg Tyr
Gly Cys Arg Trp Leu Ser Ser Arg Leu Ala Arg Gly Gln 530 535 540 cct
ctc tga 1641Pro Leu 545 7546PRTAAV-1 7Met Pro Gly Phe Tyr Glu Ile
Val Ile Lys Val Pro Ser Asp Leu Asp 1 5 10 15 Glu His Leu Pro Gly
Ile Ser Asp Ser Phe Val Ser Trp Val Ala Glu 20 25 30 Lys Glu Trp
Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 35 40 45 Glu
Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 50 55
60 Val Gln Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val
65 70 75 80 Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Leu His Ile Leu
Val Glu 85 90 95 Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe
Leu Ser Gln Ile 100 105 110 Arg Asp Lys Leu Val Gln Thr Ile Tyr Arg
Gly Ile Glu Pro Thr Leu 115 120 125 Pro Asn Trp Phe Ala Val Thr Lys
Thr Arg Asn Gly Ala Gly Gly Gly 130 135 140 Asn Lys Val Val Asp Glu
Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 145 150 155 160 Thr Gln Pro
Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Glu Tyr Ile 165 170 175 Ser
Ala Cys Leu Asn Leu Ala Glu Arg Lys Arg Leu Val Ala Gln His 180 185
190 Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Leu Asn
195 200 205 Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala
Arg Tyr 210 215 220 Met Glu Leu Val Gly Trp Leu Val Asp Arg Gly Ile
Thr Ser Glu Lys 225 230 235 240 Gln Trp Ile Gln Glu Asp Gln Ala Ser
Tyr Ile Ser Phe Asn Ala Ala 245 250 255 Ser Asn Ser Arg Ser Gln Ile
Lys Ala Ala Leu Asp Asn Ala Gly Lys 260 265 270 Ile Met Ala Leu Thr
Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ala 275 280 285 Pro Pro Ala
Asp Ile Lys Thr Asn Arg Ile Tyr Arg Ile Leu Glu Leu 290 295 300 Asn
Gly Tyr Glu Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp Ala 305 310
315 320 Gln Lys Arg Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro
Ala 325 330 335 Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His
Ala Val Pro 340 345 350 Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn
Phe Pro Phe Asn Asp 355 360 365 Cys Val Asp Lys Met Val Ile Trp Trp
Glu Glu Gly Lys
Met Thr Ala 370 375 380 Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly
Gly Ser Lys Val Arg 385 390 395 400 Val Asp Gln Lys Cys Lys Ser Ser
Ala Gln Ile Asp Pro Thr Pro Val 405 410 415 Ile Val Thr Ser Asn Thr
Asn Met Cys Ala Val Ile Asp Gly Asn Ser 420 425 430 Thr Thr Phe Glu
His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 435 440 445 Glu Leu
Thr Arg Arg Leu Glu His Asp Phe Gly Lys Val Thr Lys Gln 450 455 460
Glu Val Lys Glu Phe Phe Arg Trp Ala Gln Asp His Val Thr Glu Val 465
470 475 480 Ala His Glu Phe Tyr Val Arg Lys Gly Gly Ala Asn Lys Arg
Pro Ala 485 490 495 Pro Asp Asp Ala Asp Lys Ser Glu Pro Lys Arg Ala
Cys Pro Ser Val 500 505 510 Ala Asp Pro Ser Thr Ser Asp Ala Glu Gly
Ala Pro Val Asp Phe Ala 515 520 525 Asp Arg Tyr Gly Cys Arg Trp Leu
Ser Ser Arg Leu Ala Arg Gly Gln 530 535 540 Pro Leu 545
81200DNAAAV-1CDS(1)..(1197) 8atg gag ctg gtc ggg tgg ctg gtg gac
cgg ggc atc acc tcc gag aag 48Met Glu Leu Val Gly Trp Leu Val Asp
Arg Gly Ile Thr Ser Glu Lys 1 5 10 15 cag tgg atc cag gag gac cag
gcc tcg tac atc tcc ttc aac gcc gct 96Gln Trp Ile Gln Glu Asp Gln
Ala Ser Tyr Ile Ser Phe Asn Ala Ala 20 25 30 tcc aac tcg cgg tcc
cag atc aag gcc gct ctg gac aat gcc ggc aag 144Ser Asn Ser Arg Ser
Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 35 40 45 atc atg gcg
ctg acc aaa tcc gcg ccc gac tac ctg gta ggc ccc gct 192Ile Met Ala
Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ala 50 55 60 ccg
ccc gcg gac att aaa acc aac cgc atc tac cgc atc ctg gag ctg 240Pro
Pro Ala Asp Ile Lys Thr Asn Arg Ile Tyr Arg Ile Leu Glu Leu 65 70
75 80 aac ggc tac gaa cct gcc tac gcc ggc tcc gtc ttt ctc ggc tgg
gcc 288Asn Gly Tyr Glu Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp
Ala 85 90 95 cag aaa agg ttc ggg aag cgc aac acc atc tgg ctg ttt
ggg ccg gcc 336Gln Lys Arg Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe
Gly Pro Ala 100 105 110 acc acg ggc aag acc aac atc gcg gaa gcc atc
gcc cac gcc gtg ccc 384Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile
Ala His Ala Val Pro 115 120 125 ttc tac ggc tgc gtc aac tgg acc aat
gag aac ttt ccc ttc aat gat 432Phe Tyr Gly Cys Val Asn Trp Thr Asn
Glu Asn Phe Pro Phe Asn Asp 130 135 140 tgc gtc gac aag atg gtg atc
tgg tgg gag gag ggc aag atg acg gcc 480Cys Val Asp Lys Met Val Ile
Trp Trp Glu Glu Gly Lys Met Thr Ala 145 150 155 160 aag gtc gtg gag
tcc gcc aag gcc att ctc ggc ggc agc aag gtg cgc 528Lys Val Val Glu
Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 165 170 175 gtg gac
caa aag tgc aag tcg tcc gcc cag atc gac ccc acc ccc gtg 576Val Asp
Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 180 185 190
atc gtc acc tcc aac acc aac atg tgc gcc gtg att gac ggg aac agc
624Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser
195 200 205 acc acc ttc gag cac cag cag ccg ttg cag gac cgg atg ttc
aaa ttt 672Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe
Lys Phe 210 215 220 gaa ctc acc cgc cgt ctg gag cat gac ttt ggc aag
gtg aca aag cag 720Glu Leu Thr Arg Arg Leu Glu His Asp Phe Gly Lys
Val Thr Lys Gln 225 230 235 240 gaa gtc aaa gag ttc ttc cgc tgg gcg
cag gat cac gtg acc gag gtg 768Glu Val Lys Glu Phe Phe Arg Trp Ala
Gln Asp His Val Thr Glu Val 245 250 255 gcg cat gag ttc tac gtc aga
aag ggt gga gcc aac aaa aga ccc gcc 816Ala His Glu Phe Tyr Val Arg
Lys Gly Gly Ala Asn Lys Arg Pro Ala 260 265 270 ccc gat gac gcg gat
aaa agc gag ccc aag cgg gcc tgc ccc tca gtc 864Pro Asp Asp Ala Asp
Lys Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 275 280 285 gcg gat cca
tcg acg tca gac gcg gaa gga gct ccg gtg gac ttt gcc 912Ala Asp Pro
Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 290 295 300 gac
agg tac caa aac aaa tgt tct cgt cac gcg ggc atg ctt cag atg 960Asp
Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met Leu Gln Met 305 310
315 320 ctg ttt ccc tgc aag aca tgc gag aga atg aat cag aat ttc aac
att 1008Leu Phe Pro Cys Lys Thr Cys Glu Arg Met Asn Gln Asn Phe Asn
Ile 325 330 335 tgc ttc acg cac ggg acg aga gac tgt tca gag tgc ttc
ccc ggc gtg 1056Cys Phe Thr His Gly Thr Arg Asp Cys Ser Glu Cys Phe
Pro Gly Val 340 345 350 tca gaa tct caa ccg gtc gtc aga aag agg acg
tat cgg aaa ctc tgt 1104Ser Glu Ser Gln Pro Val Val Arg Lys Arg Thr
Tyr Arg Lys Leu Cys 355 360 365 gcc att cat cat ctg ctg ggg cgg gct
ccc gag att gct tgc tcg gcc 1152Ala Ile His His Leu Leu Gly Arg Ala
Pro Glu Ile Ala Cys Ser Ala 370 375 380 tgc gat ctg gtc aac gtg gac
ctg gat gac tgt gtt tct gag caa taa 1200Cys Asp Leu Val Asn Val Asp
Leu Asp Asp Cys Val Ser Glu Gln 385 390 395 9399PRTAAV-1 9Met Glu
Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 1 5 10 15
Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 20
25 30 Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly
Lys 35 40 45 Ile Met Ala Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val
Gly Pro Ala 50 55 60 Pro Pro Ala Asp Ile Lys Thr Asn Arg Ile Tyr
Arg Ile Leu Glu Leu 65 70 75 80 Asn Gly Tyr Glu Pro Ala Tyr Ala Gly
Ser Val Phe Leu Gly Trp Ala 85 90 95 Gln Lys Arg Phe Gly Lys Arg
Asn Thr Ile Trp Leu Phe Gly Pro Ala 100 105 110 Thr Thr Gly Lys Thr
Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 115 120 125 Phe Tyr Gly
Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 130 135 140 Cys
Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 145 150
155 160 Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val
Arg 165 170 175 Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro
Thr Pro Val 180 185 190 Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val
Ile Asp Gly Asn Ser 195 200 205 Thr Thr Phe Glu His Gln Gln Pro Leu
Gln Asp Arg Met Phe Lys Phe 210 215 220 Glu Leu Thr Arg Arg Leu Glu
His Asp Phe Gly Lys Val Thr Lys Gln 225 230 235 240 Glu Val Lys Glu
Phe Phe Arg Trp Ala Gln Asp His Val Thr Glu Val 245 250 255 Ala His
Glu Phe Tyr Val Arg Lys Gly Gly Ala Asn Lys Arg Pro Ala 260 265 270
Pro Asp Asp Ala Asp Lys Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 275
280 285 Ala Asp Pro Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe
Ala 290 295 300 Asp Arg Tyr Gln Asn Lys Cys Ser Arg His Ala Gly Met
Leu Gln Met 305 310 315 320 Leu Phe Pro Cys Lys Thr Cys Glu Arg Met
Asn Gln Asn Phe Asn Ile 325 330 335 Cys Phe Thr His Gly Thr Arg Asp
Cys Ser Glu Cys Phe Pro Gly Val 340 345 350 Ser Glu Ser Gln Pro Val
Val Arg Lys Arg Thr Tyr Arg Lys Leu Cys 355 360 365 Ala Ile His His
Leu Leu Gly Arg Ala Pro Glu Ile Ala Cys Ser Ala 370 375 380 Cys Asp
Leu Val Asn Val Asp Leu Asp Asp Cys Val Ser Glu Gln 385 390 395
10969DNAAAV-1CDS(1)..(966) 10atg gag ctg gtc ggg tgg ctg gtg gac
cgg ggc atc acc tcc gag aag 48Met Glu Leu Val Gly Trp Leu Val Asp
Arg Gly Ile Thr Ser Glu Lys 1 5 10 15 cag tgg atc cag gag gac cag
gcc tcg tac atc tcc ttc aac gcc gct 96Gln Trp Ile Gln Glu Asp Gln
Ala Ser Tyr Ile Ser Phe Asn Ala Ala 20 25 30 tcc aac tcg cgg tcc
cag atc aag gcc gct ctg gac aat gcc ggc aag 144Ser Asn Ser Arg Ser
Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 35 40 45 atc atg gcg
ctg acc aaa tcc gcg ccc gac tac ctg gta ggc ccc gct 192Ile Met Ala
Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val Gly Pro Ala 50 55 60 ccg
ccc gcg gac att aaa acc aac cgc atc tac cgc atc ctg gag ctg 240Pro
Pro Ala Asp Ile Lys Thr Asn Arg Ile Tyr Arg Ile Leu Glu Leu 65 70
75 80 aac ggc tac gaa cct gcc tac gcc ggc tcc gtc ttt ctc ggc tgg
gcc 288Asn Gly Tyr Glu Pro Ala Tyr Ala Gly Ser Val Phe Leu Gly Trp
Ala 85 90 95 cag aaa agg ttc ggg aag cgc aac acc atc tgg ctg ttt
ggg ccg gcc 336Gln Lys Arg Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe
Gly Pro Ala 100 105 110 acc acg ggc aag acc aac atc gcg gaa gcc atc
gcc cac gcc gtg ccc 384Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile
Ala His Ala Val Pro 115 120 125 ttc tac ggc tgc gtc aac tgg acc aat
gag aac ttt ccc ttc aat gat 432Phe Tyr Gly Cys Val Asn Trp Thr Asn
Glu Asn Phe Pro Phe Asn Asp 130 135 140 tgc gtc gac aag atg gtg atc
tgg tgg gag gag ggc aag atg acg gcc 480Cys Val Asp Lys Met Val Ile
Trp Trp Glu Glu Gly Lys Met Thr Ala 145 150 155 160 aag gtc gtg gag
tcc gcc aag gcc att ctc ggc ggc agc aag gtg cgc 528Lys Val Val Glu
Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 165 170 175 gtg gac
caa aag tgc aag tcg tcc gcc cag atc gac ccc acc ccc gtg 576Val Asp
Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 180 185 190
atc gtc acc tcc aac acc aac atg tgc gcc gtg att gac ggg aac agc
624Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser
195 200 205 acc acc ttc gag cac cag cag ccg ttg cag gac cgg atg ttc
aaa ttt 672Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe
Lys Phe 210 215 220 gaa ctc acc cgc cgt ctg gag cat gac ttt ggc aag
gtg aca aag cag 720Glu Leu Thr Arg Arg Leu Glu His Asp Phe Gly Lys
Val Thr Lys Gln 225 230 235 240 gaa gtc aaa gag ttc ttc cgc tgg gcg
cag gat cac gtg acc gag gtg 768Glu Val Lys Glu Phe Phe Arg Trp Ala
Gln Asp His Val Thr Glu Val 245 250 255 gcg cat gag ttc tac gtc aga
aag ggt gga gcc aac aaa aga ccc gcc 816Ala His Glu Phe Tyr Val Arg
Lys Gly Gly Ala Asn Lys Arg Pro Ala 260 265 270 ccc gat gac gcg gat
aaa agc gag ccc aag cgg gcc tgc ccc tca gtc 864Pro Asp Asp Ala Asp
Lys Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 275 280 285 gcg gat cca
tcg acg tca gac gcg gaa gga gct ccg gtg gac ttt gcc 912Ala Asp Pro
Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe Ala 290 295 300 gac
agg tat ggc tgc cga tgg tta tct tcc aga ttg gct cga gga caa 960Asp
Arg Tyr Gly Cys Arg Trp Leu Ser Ser Arg Leu Ala Arg Gly Gln 305 310
315 320 cct ctc tga 969Pro Leu
11322PRTAAV-1misc_feature(943)..(944)minor splice site 11Met Glu
Leu Val Gly Trp Leu Val Asp Arg Gly Ile Thr Ser Glu Lys 1 5 10 15
Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 20
25 30 Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly
Lys 35 40 45 Ile Met Ala Leu Thr Lys Ser Ala Pro Asp Tyr Leu Val
Gly Pro Ala 50 55 60 Pro Pro Ala Asp Ile Lys Thr Asn Arg Ile Tyr
Arg Ile Leu Glu Leu 65 70 75 80 Asn Gly Tyr Glu Pro Ala Tyr Ala Gly
Ser Val Phe Leu Gly Trp Ala 85 90 95 Gln Lys Arg Phe Gly Lys Arg
Asn Thr Ile Trp Leu Phe Gly Pro Ala 100 105 110 Thr Thr Gly Lys Thr
Asn Ile Ala Glu Ala Ile Ala His Ala Val Pro 115 120 125 Phe Tyr Gly
Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 130 135 140 Cys
Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 145 150
155 160 Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val
Arg 165 170 175 Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro
Thr Pro Val 180 185 190 Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val
Ile Asp Gly Asn Ser 195 200 205 Thr Thr Phe Glu His Gln Gln Pro Leu
Gln Asp Arg Met Phe Lys Phe 210 215 220 Glu Leu Thr Arg Arg Leu Glu
His Asp Phe Gly Lys Val Thr Lys Gln 225 230 235 240 Glu Val Lys Glu
Phe Phe Arg Trp Ala Gln Asp His Val Thr Glu Val 245 250 255 Ala His
Glu Phe Tyr Val Arg Lys Gly Gly Ala Asn Lys Arg Pro Ala 260 265 270
Pro Asp Asp Ala Asp Lys Ser Glu Pro Lys Arg Ala Cys Pro Ser Val 275
280 285 Ala Asp Pro Ser Thr Ser Asp Ala Glu Gly Ala Pro Val Asp Phe
Ala 290 295 300 Asp Arg Tyr Gly Cys Arg Trp Leu Ser Ser Arg Leu Ala
Arg Gly Gln 305 310 315 320 Pro Leu 122211DNAAAV-1CDS(1)..(2208)
12atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct
48Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 1
5 10 15 gag ggc att cgc gag tgg tgg gac ttg aaa cct gga gcc ccg aag
ccc 96Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys
Pro 20 25 30 aaa gcc aac cag caa aag cag gac gac ggc cgg ggt ctg
gtg ctt cct 144Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu
Val Leu Pro 35 40 45 ggc tac aag tac ctc gga ccc ttc aac gga ctc
gac aag ggg gag ccc 192Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu
Asp Lys Gly Glu Pro 50 55 60 gtc aac gcg gcg gac gca gcg gcc ctc
gag cac gac aag gcc tac gac 240Val Asn Ala Ala Asp Ala Ala Ala Leu
Glu His Asp Lys Ala Tyr Asp 65 70 75
80 cag cag ctc aaa gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc
288Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala
85 90 95 gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tct ttt
ggg ggc 336Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe
Gly Gly 100 105 110 aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg
gtt ctc gaa cct 384Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg
Val Leu Glu Pro 115 120 125 ctc ggt ctg gtt gag gaa ggc gct aag acg
gct cct gga aag aaa cgt 432Leu Gly Leu Val Glu Glu Gly Ala Lys Thr
Ala Pro Gly Lys Lys Arg 130 135 140 ccg gta gag cag tcg cca caa gag
cca gac tcc tcc tcg ggc atc ggc 480Pro Val Glu Gln Ser Pro Gln Glu
Pro Asp Ser Ser Ser Gly Ile Gly 145 150 155 160 aag aca ggc cag cag
ccc gct aaa aag aga ctc aat ttt ggt cag act 528Lys Thr Gly Gln Gln
Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 165 170 175 ggc gac tca
gag tca gtc ccc gat cca caa cct ctc gga gaa cct cca 576Gly Asp Ser
Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 180 185 190 gca
acc ccc gct gct gtg gga cct act aca atg gct tca ggc ggt ggc 624Ala
Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 195 200
205 gca cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc
672Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala
210 215 220 tca gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga
gtc atc 720Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg
Val Ile 225 230 235 240 acc acc agc acc cgc acc tgg gcc ttg ccc acc
tac aat aac cac ctc 768Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr
Tyr Asn Asn His Leu 245 250 255 tac aag caa atc tcc agt gct tca acg
ggg gcc agc aac gac aac cac 816Tyr Lys Gln Ile Ser Ser Ala Ser Thr
Gly Ala Ser Asn Asp Asn His 260 265 270 tac ttc ggc tac agc acc ccc
tgg ggg tat ttt gat ttc aac aga ttc 864Tyr Phe Gly Tyr Ser Thr Pro
Trp Gly Tyr Phe Asp Phe Asn Arg Phe 275 280 285 cac tgc cac ttt tca
cca cgt gac tgg cag cga ctc atc aac aac aat 912His Cys His Phe Ser
Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 290 295 300 tgg gga ttc
cgg ccc aag aga ctc aac ttc aaa ctc ttc aac atc caa 960Trp Gly Phe
Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 305 310 315 320
gtc aag gag gtc acg acg aat gat ggc gtc aca acc atc gct aat aac
1008Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn
325 330 335 ctt acc agc acg gtt caa gtc ttc tcg gac tcg gag tac cag
ctt ccg 1056Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln
Leu Pro 340 345 350 tac gtc ctc ggc tct gcg cac cag ggc tgc ctc cct
ccg ttc ccg gcg 1104Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro
Pro Phe Pro Ala 355 360 365 gac gtg ttc atg att ccg caa tac ggc tac
ctg acg ctc aac aat ggc 1152Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr
Leu Thr Leu Asn Asn Gly 370 375 380 agc caa gcc gtg gga cgt tca tcc
ttt tac tgc ctg gaa tat ttc cct 1200Ser Gln Ala Val Gly Arg Ser Ser
Phe Tyr Cys Leu Glu Tyr Phe Pro 385 390 395 400 tct cag atg ctg aga
acg ggc aac aac ttt acc ttc agc tac acc ttt 1248Ser Gln Met Leu Arg
Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 405 410 415 gag gaa gtg
cct ttc cac agc agc tac gcg cac agc cag agc ctg gac 1296Glu Glu Val
Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 420 425 430 cgg
ctg atg aat cct ctc atc gac caa tac ctg tat tac ctg aac aga 1344Arg
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 435 440
445 act caa aat cag tcc gga agt gcc caa aac aag gac ttg ctg ttt agc
1392Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser
450 455 460 cgt ggg tct cca gct ggc atg tct gtt cag ccc aaa aac tgg
cta cct 1440Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp
Leu Pro 465 470 475 480 gga ccc tgt tat cgg cag cag cgc gtt tct aaa
aca aaa aca gac aac 1488Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys
Thr Lys Thr Asp Asn 485 490 495 aac aac agc aat ttt acc tgg act ggt
gct tca aaa tat aac ctc aat 1536Asn Asn Ser Asn Phe Thr Trp Thr Gly
Ala Ser Lys Tyr Asn Leu Asn 500 505 510 ggg cgt gaa tcc atc atc aac
cct ggc act gct atg gcc tca cac aaa 1584Gly Arg Glu Ser Ile Ile Asn
Pro Gly Thr Ala Met Ala Ser His Lys 515 520 525 gac gac gaa gac aag
ttc ttt ccc atg agc ggt gtc atg att ttt gga 1632Asp Asp Glu Asp Lys
Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 530 535 540 aaa gag agc
gcc gga gct tca aac act gca ttg gac aat gtc atg att 1680Lys Glu Ser
Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 545 550 555 560
aca gac gaa gag gaa att aaa gcc act aac cct gtg gcc acc gaa aga
1728Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg
565 570 575 ttt ggg acc gtg gca gtc aat ttc cag agc agc agc aca gac
cct gcg 1776Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp
Pro Ala 580 585 590 acc gga gat gtg cat gct atg gga gca tta cct ggc
atg gtg tgg caa 1824Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly
Met Val Trp Gln 595 600 605 gat aga gac gtg tac ctg cag ggt ccc att
tgg gcc aaa att cct cac 1872Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile
Trp Ala Lys Ile Pro His 610 615 620 aca gat gga cac ttt cac ccg tct
cct ctt atg ggc ggc ttt gga ctc 1920Thr Asp Gly His Phe His Pro Ser
Pro Leu Met Gly Gly Phe Gly Leu 625 630 635 640 aag aac ccg cct cct
cag atc ctc atc aaa aac acg cct gtt cct gcg 1968Lys Asn Pro Pro Pro
Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 645 650 655 aat cct ccg
gcg gag ttt tca gct aca aag ttt gct tca ttc atc acc 2016Asn Pro Pro
Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 660 665 670 caa
tac tcc aca gga caa gtg agt gtg gaa att gaa tgg gag ctg cag 2064Gln
Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 675 680
685 aaa gaa aac agc aag cgc tgg aat ccc gaa gtg cag tac aca tcc aat
2112Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn
690 695 700 tat gca aaa tct gcc aac gtt gat ttt act gtg gac aac aat
gga ctt 2160Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn
Gly Leu 705 710 715 720 tat act gag cct cgc ccc att ggc acc cgt tac
ctt acc cgt ccc ctg 2208Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr
Leu Thr Arg Pro Leu 725 730 735 taa 221113736PRTAAV-1 13Met Ala Ala
Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 1 5 10 15 Glu
Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 20 25
30 Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro
35 40 45 Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly
Glu Pro 50 55 60 Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp
Lys Ala Tyr Asp 65 70 75 80 Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr
Leu Arg Tyr Asn His Ala 85 90 95 Asp Ala Glu Phe Gln Glu Arg Leu
Gln Glu Asp Thr Ser Phe Gly Gly 100 105 110 Asn Leu Gly Arg Ala Val
Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 115 120 125 Leu Gly Leu Val
Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 130 135 140 Pro Val
Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 145 150 155
160 Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr
165 170 175 Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu
Pro Pro 180 185 190 Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala
Ser Gly Gly Gly 195 200 205 Ala Pro Met Ala Asp Asn Asn Glu Gly Ala
Asp Gly Val Gly Asn Ala 210 215 220 Ser Gly Asn Trp His Cys Asp Ser
Thr Trp Leu Gly Asp Arg Val Ile 225 230 235 240 Thr Thr Ser Thr Arg
Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 245 250 255 Tyr Lys Gln
Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 260 265 270 Tyr
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 275 280
285 His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn
290 295 300 Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn
Ile Gln 305 310 315 320 Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr
Thr Ile Ala Asn Asn 325 330 335 Leu Thr Ser Thr Val Gln Val Phe Ser
Asp Ser Glu Tyr Gln Leu Pro 340 345 350 Tyr Val Leu Gly Ser Ala His
Gln Gly Cys Leu Pro Pro Phe Pro Ala 355 360 365 Asp Val Phe Met Ile
Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 370 375 380 Ser Gln Ala
Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 385 390 395 400
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 405
410 415 Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu
Asp 420 425 430 Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr
Leu Asn Arg 435 440 445 Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys
Asp Leu Leu Phe Ser 450 455 460 Arg Gly Ser Pro Ala Gly Met Ser Val
Gln Pro Lys Asn Trp Leu Pro 465 470 475 480 Gly Pro Cys Tyr Arg Gln
Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 485 490 495 Asn Asn Ser Asn
Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 500 505 510 Gly Arg
Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 515 520 525
Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 530
535 540 Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met
Ile 545 550 555 560 Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val
Ala Thr Glu Arg 565 570 575 Phe Gly Thr Val Ala Val Asn Phe Gln Ser
Ser Ser Thr Asp Pro Ala 580 585 590 Thr Gly Asp Val His Ala Met Gly
Ala Leu Pro Gly Met Val Trp Gln 595 600 605 Asp Arg Asp Val Tyr Leu
Gln Gly Pro Ile Trp Ala Lys Ile Pro His 610 615 620 Thr Asp Gly His
Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 625 630 635 640 Lys
Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 645 650
655 Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr
660 665 670 Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu
Leu Gln 675 680 685 Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln
Tyr Thr Ser Asn 690 695 700 Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr
Val Asp Asn Asn Gly Leu 705 710 715 720 Tyr Thr Glu Pro Arg Pro Ile
Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 735
141800DNAAAV-1CDS(1)..(1797) 14acg gct cct gga aag aaa cgt ccg gta
gag cag tcg cca caa gag cca 48Thr Ala Pro Gly Lys Lys Arg Pro Val
Glu Gln Ser Pro Gln Glu Pro 1 5 10 15 gac tcc tcc tcg ggc atc ggc
aag aca ggc cag cag ccc gct aaa aag 96Asp Ser Ser Ser Gly Ile Gly
Lys Thr Gly Gln Gln Pro Ala Lys Lys 20 25 30 aga ctc aat ttt ggt
cag act ggc gac tca gag tca gtc ccc gat cca 144Arg Leu Asn Phe Gly
Gln Thr Gly Asp Ser Glu Ser Val Pro Asp Pro 35 40 45 caa cct ctc
gga gaa cct cca gca acc ccc gct gct gtg gga cct act 192Gln Pro Leu
Gly Glu Pro Pro Ala Thr Pro Ala Ala Val Gly Pro Thr 50 55 60 aca
atg gct tca ggc ggt ggc gca cca atg gca gac aat aac gaa ggc 240Thr
Met Ala Ser Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu Gly 65 70
75 80 gcc gac gga gtg ggt aat gcc tca gga aat tgg cat tgc gat tcc
aca 288Ala Asp Gly Val Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser
Thr 85 90 95 tgg ctg ggc gac aga gtc atc acc acc agc acc cgc acc
tgg gcc ttg 336Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr
Trp Ala Leu 100 105 110 ccc acc tac aat aac cac ctc tac aag caa atc
tcc agt gct tca acg 384Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile
Ser Ser Ala Ser Thr 115 120 125 ggg gcc agc aac gac aac cac tac ttc
ggc tac agc acc ccc tgg ggg 432Gly Ala Ser Asn Asp Asn His Tyr Phe
Gly Tyr Ser Thr Pro Trp Gly 130 135 140 tat ttt gat ttc aac aga ttc
cac tgc cac ttt tca cca cgt gac tgg 480Tyr Phe Asp Phe Asn Arg Phe
His Cys His Phe Ser Pro Arg Asp Trp 145 150 155 160 cag cga ctc atc
aac aac aat tgg gga ttc cgg ccc aag aga ctc aac 528Gln Arg Leu Ile
Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 165 170 175 ttc aaa
ctc ttc aac atc caa gtc aag gag gtc acg acg aat gat ggc 576Phe Lys
Leu Phe Asn Ile Gln Val Lys Glu Val Thr Thr Asn Asp Gly 180 185 190
gtc aca acc atc gct aat aac ctt acc agc acg gtt caa gtc ttc tcg
624Val Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ser
195 200 205 gac tcg gag tac cag ctt ccg tac gtc ctc ggc tct gcg cac
cag ggc 672Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His
Gln Gly 210 215 220 tgc ctc cct ccg ttc ccg gcg gac gtg ttc atg att
ccg caa tac ggc 720Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile
Pro Gln Tyr Gly 225 230 235 240 tac ctg acg ctc aac aat ggc agc caa
gcc gtg gga cgt tca tcc ttt 768Tyr Leu Thr Leu Asn Asn Gly Ser Gln
Ala Val Gly Arg Ser Ser Phe
245 250 255 tac tgc ctg gaa tat ttc cct tct cag atg ctg aga acg ggc
aac aac 816Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly
Asn Asn 260 265 270 ttt acc ttc agc tac acc ttt gag gaa gtg cct ttc
cac agc agc tac 864Phe Thr Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe
His Ser Ser Tyr 275 280 285 gcg cac agc cag agc ctg gac cgg ctg atg
aat cct ctc atc gac caa 912Ala His Ser Gln Ser Leu Asp Arg Leu Met
Asn Pro Leu Ile Asp Gln 290 295 300 tac ctg tat tac ctg aac aga act
caa aat cag tcc gga agt gcc caa 960Tyr Leu Tyr Tyr Leu Asn Arg Thr
Gln Asn Gln Ser Gly Ser Ala Gln 305 310 315 320 aac aag gac ttg ctg
ttt agc cgt ggg tct cca gct ggc atg tct gtt 1008Asn Lys Asp Leu Leu
Phe Ser Arg Gly Ser Pro Ala Gly Met Ser Val 325 330 335 cag ccc aaa
aac tgg cta cct gga ccc tgt tat cgg cag cag cgc gtt 1056Gln Pro Lys
Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val 340 345 350 tct
aaa aca aaa aca gac aac aac aac agc aat ttt acc tgg act ggt 1104Ser
Lys Thr Lys Thr Asp Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly 355 360
365 gct tca aaa tat aac ctc aat ggg cgt gaa tcc atc atc aac cct ggc
1152Ala Ser Lys Tyr Asn Leu Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly
370 375 380 act gct atg gcc tca cac aaa gac gac gaa gac aag ttc ttt
ccc atg 1200Thr Ala Met Ala Ser His Lys Asp Asp Glu Asp Lys Phe Phe
Pro Met 385 390 395 400 agc ggt gtc atg att ttt gga aaa gag agc gcc
gga gct tca aac act 1248Ser Gly Val Met Ile Phe Gly Lys Glu Ser Ala
Gly Ala Ser Asn Thr 405 410 415 gca ttg gac aat gtc atg att aca gac
gaa gag gaa att aaa gcc act 1296Ala Leu Asp Asn Val Met Ile Thr Asp
Glu Glu Glu Ile Lys Ala Thr 420 425 430 aac cct gtg gcc acc gaa aga
ttt ggg acc gtg gca gtc aat ttc cag 1344Asn Pro Val Ala Thr Glu Arg
Phe Gly Thr Val Ala Val Asn Phe Gln 435 440 445 agc agc agc aca gac
cct gcg acc gga gat gtg cat gct atg gga gca 1392Ser Ser Ser Thr Asp
Pro Ala Thr Gly Asp Val His Ala Met Gly Ala 450 455 460 tta cct ggc
atg gtg tgg caa gat aga gac gtg tac ctg cag ggt ccc 1440Leu Pro Gly
Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 465 470 475 480
att tgg gcc aaa att cct cac aca gat gga cac ttt cac ccg tct cct
1488Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro
485 490 495 ctt atg ggc ggc ttt gga ctc aag aac ccg cct cct cag atc
ctc atc 1536Leu Met Gly Gly Phe Gly Leu Lys Asn Pro Pro Pro Gln Ile
Leu Ile 500 505 510 aaa aac acg cct gtt cct gcg aat cct ccg gcg gag
ttt tca gct aca 1584Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Ala Glu
Phe Ser Ala Thr 515 520 525 aag ttt gct tca ttc atc acc caa tac tcc
aca gga caa gtg agt gtg 1632Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser
Thr Gly Gln Val Ser Val 530 535 540 gaa att gaa tgg gag ctg cag aaa
gaa aac agc aag cgc tgg aat ccc 1680Glu Ile Glu Trp Glu Leu Gln Lys
Glu Asn Ser Lys Arg Trp Asn Pro 545 550 555 560 gaa gtg cag tac aca
tcc aat tat gca aaa tct gcc aac gtt gat ttt 1728Glu Val Gln Tyr Thr
Ser Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe 565 570 575 act gtg gac
aac aat gga ctt tat act gag cct cgc ccc att ggc acc 1776Thr Val Asp
Asn Asn Gly Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr 580 585 590 cgt
tac ctt acc cgt ccc ctg taa 1800Arg Tyr Leu Thr Arg Pro Leu 595
15599PRTAAV-1 15Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Gln Ser Pro
Gln Glu Pro 1 5 10 15 Asp Ser Ser Ser Gly Ile Gly Lys Thr Gly Gln
Gln Pro Ala Lys Lys 20 25 30 Arg Leu Asn Phe Gly Gln Thr Gly Asp
Ser Glu Ser Val Pro Asp Pro 35 40 45 Gln Pro Leu Gly Glu Pro Pro
Ala Thr Pro Ala Ala Val Gly Pro Thr 50 55 60 Thr Met Ala Ser Gly
Gly Gly Ala Pro Met Ala Asp Asn Asn Glu Gly 65 70 75 80 Ala Asp Gly
Val Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser Thr 85 90 95 Trp
Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 100 105
110 Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr
115 120 125 Gly Ala Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro
Trp Gly 130 135 140 Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser
Pro Arg Asp Trp 145 150 155 160 Gln Arg Leu Ile Asn Asn Asn Trp Gly
Phe Arg Pro Lys Arg Leu Asn 165 170 175 Phe Lys Leu Phe Asn Ile Gln
Val Lys Glu Val Thr Thr Asn Asp Gly 180 185 190 Val Thr Thr Ile Ala
Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ser 195 200 205 Asp Ser Glu
Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly 210 215 220 Cys
Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 225 230
235 240 Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser
Phe 245 250 255 Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr
Gly Asn Asn 260 265 270 Phe Thr Phe Ser Tyr Thr Phe Glu Glu Val Pro
Phe His Ser Ser Tyr 275 280 285 Ala His Ser Gln Ser Leu Asp Arg Leu
Met Asn Pro Leu Ile Asp Gln 290 295 300 Tyr Leu Tyr Tyr Leu Asn Arg
Thr Gln Asn Gln Ser Gly Ser Ala Gln 305 310 315 320 Asn Lys Asp Leu
Leu Phe Ser Arg Gly Ser Pro Ala Gly Met Ser Val 325 330 335 Gln Pro
Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val 340 345 350
Ser Lys Thr Lys Thr Asp Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly 355
360 365 Ala Ser Lys Tyr Asn Leu Asn Gly Arg Glu Ser Ile Ile Asn Pro
Gly 370 375 380 Thr Ala Met Ala Ser His Lys Asp Asp Glu Asp Lys Phe
Phe Pro Met 385 390 395 400 Ser Gly Val Met Ile Phe Gly Lys Glu Ser
Ala Gly Ala Ser Asn Thr 405 410 415 Ala Leu Asp Asn Val Met Ile Thr
Asp Glu Glu Glu Ile Lys Ala Thr 420 425 430 Asn Pro Val Ala Thr Glu
Arg Phe Gly Thr Val Ala Val Asn Phe Gln 435 440 445 Ser Ser Ser Thr
Asp Pro Ala Thr Gly Asp Val His Ala Met Gly Ala 450 455 460 Leu Pro
Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 465 470 475
480 Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro
485 490 495 Leu Met Gly Gly Phe Gly Leu Lys Asn Pro Pro Pro Gln Ile
Leu Ile 500 505 510 Lys Asn Thr Pro Val Pro Ala Asn Pro Pro Ala Glu
Phe Ser Ala Thr 515 520 525 Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser
Thr Gly Gln Val Ser Val 530 535 540 Glu Ile Glu Trp Glu Leu Gln Lys
Glu Asn Ser Lys Arg Trp Asn Pro 545 550 555 560 Glu Val Gln Tyr Thr
Ser Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe 565 570 575 Thr Val Asp
Asn Asn Gly Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr 580 585 590 Arg
Tyr Leu Thr Arg Pro Leu 595 161605DNAAAV-1CDS(1)..(1602) 16atg gct
tca ggc ggt ggc gca cca atg gca gac aat aac gaa ggc gcc 48Met Ala
Ser Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 1 5 10 15
gac gga gtg ggt aat gcc tca gga aat tgg cat tgc gat tcc aca tgg
96Asp Gly Val Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp
20 25 30 ctg ggc gac aga gtc atc acc acc agc acc cgc acc tgg gcc
ttg ccc 144Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala
Leu Pro 35 40 45 acc tac aat aac cac ctc tac aag caa atc tcc agt
gct tca acg ggg 192Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser
Ala Ser Thr Gly 50 55 60 gcc agc aac gac aac cac tac ttc ggc tac
agc acc ccc tgg ggg tat 240Ala Ser Asn Asp Asn His Tyr Phe Gly Tyr
Ser Thr Pro Trp Gly Tyr 65 70 75 80 ttt gat ttc aac aga ttc cac tgc
cac ttt tca cca cgt gac tgg cag 288Phe Asp Phe Asn Arg Phe His Cys
His Phe Ser Pro Arg Asp Trp Gln 85 90 95 cga ctc atc aac aac aat
tgg gga ttc cgg ccc aag aga ctc aac ttc 336Arg Leu Ile Asn Asn Asn
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe 100 105 110 aaa ctc ttc aac
atc caa gtc aag gag gtc acg acg aat gat ggc gtc 384Lys Leu Phe Asn
Ile Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val 115 120 125 aca acc
atc gct aat aac ctt acc agc acg gtt caa gtc ttc tcg gac 432Thr Thr
Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp 130 135 140
tcg gag tac cag ctt ccg tac gtc ctc ggc tct gcg cac cag ggc tgc
480Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys
145 150 155 160 ctc cct ccg ttc ccg gcg gac gtg ttc atg att ccg caa
tac ggc tac 528Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln
Tyr Gly Tyr 165 170 175 ctg acg ctc aac aat ggc agc caa gcc gtg gga
cgt tca tcc ttt tac 576Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly
Arg Ser Ser Phe Tyr 180 185 190 tgc ctg gaa tat ttc cct tct cag atg
ctg aga acg ggc aac aac ttt 624Cys Leu Glu Tyr Phe Pro Ser Gln Met
Leu Arg Thr Gly Asn Asn Phe 195 200 205 acc ttc agc tac acc ttt gag
gaa gtg cct ttc cac agc agc tac gcg 672Thr Phe Ser Tyr Thr Phe Glu
Glu Val Pro Phe His Ser Ser Tyr Ala 210 215 220 cac agc cag agc ctg
gac cgg ctg atg aat cct ctc atc gac caa tac 720His Ser Gln Ser Leu
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr 225 230 235 240 ctg tat
tac ctg aac aga act caa aat cag tcc gga agt gcc caa aac 768Leu Tyr
Tyr Leu Asn Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn 245 250 255
aag gac ttg ctg ttt agc cgt ggg tct cca gct ggc atg tct gtt cag
816Lys Asp Leu Leu Phe Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln
260 265 270 ccc aaa aac tgg cta cct gga ccc tgt tat cgg cag cag cgc
gtt tct 864Pro Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg
Val Ser 275 280 285 aaa aca aaa aca gac aac aac aac agc aat ttt acc
tgg act ggt gct 912Lys Thr Lys Thr Asp Asn Asn Asn Ser Asn Phe Thr
Trp Thr Gly Ala 290 295 300 tca aaa tat aac ctc aat ggg cgt gaa tcc
atc atc aac cct ggc act 960Ser Lys Tyr Asn Leu Asn Gly Arg Glu Ser
Ile Ile Asn Pro Gly Thr 305 310 315 320 gct atg gcc tca cac aaa gac
gac gaa gac aag ttc ttt ccc atg agc 1008Ala Met Ala Ser His Lys Asp
Asp Glu Asp Lys Phe Phe Pro Met Ser 325 330 335 ggt gtc atg att ttt
gga aaa gag agc gcc gga gct tca aac act gca 1056Gly Val Met Ile Phe
Gly Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala 340 345 350 ttg gac aat
gtc atg att aca gac gaa gag gaa att aaa gcc act aac 1104Leu Asp Asn
Val Met Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn 355 360 365 cct
gtg gcc acc gaa aga ttt ggg acc gtg gca gtc aat ttc cag agc 1152Pro
Val Ala Thr Glu Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser 370 375
380 agc agc aca gac cct gcg acc gga gat gtg cat gct atg gga gca tta
1200Ser Ser Thr Asp Pro Ala Thr Gly Asp Val His Ala Met Gly Ala Leu
385 390 395 400 cct ggc atg gtg tgg caa gat aga gac gtg tac ctg cag
ggt ccc att 1248Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln
Gly Pro Ile 405 410 415 tgg gcc aaa att cct cac aca gat gga cac ttt
cac ccg tct cct ctt 1296Trp Ala Lys Ile Pro His Thr Asp Gly His Phe
His Pro Ser Pro Leu 420 425 430 atg ggc ggc ttt gga ctc aag aac ccg
cct cct cag atc ctc atc aaa 1344Met Gly Gly Phe Gly Leu Lys Asn Pro
Pro Pro Gln Ile Leu Ile Lys 435 440 445 aac acg cct gtt cct gcg aat
cct ccg gcg gag ttt tca gct aca aag 1392Asn Thr Pro Val Pro Ala Asn
Pro Pro Ala Glu Phe Ser Ala Thr Lys 450 455 460 ttt gct tca ttc atc
acc caa tac tcc aca gga caa gtg agt gtg gaa 1440Phe Ala Ser Phe Ile
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 465 470 475 480 att gaa
tgg gag ctg cag aaa gaa aac agc aag cgc tgg aat ccc gaa 1488Ile Glu
Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 485 490 495
gtg cag tac aca tcc aat tat gca aaa tct gcc aac gtt gat ttt act
1536Val Gln Tyr Thr Ser Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr
500 505 510 gtg gac aac aat gga ctt tat act gag cct cgc ccc att ggc
acc cgt 1584Val Asp Asn Asn Gly Leu Tyr Thr Glu Pro Arg Pro Ile Gly
Thr Arg 515 520 525 tac ctt acc cgt ccc ctg taa 1605Tyr Leu Thr Arg
Pro Leu 530 17534PRTAAV-1 17Met Ala Ser Gly Gly Gly Ala Pro Met Ala
Asp Asn Asn Glu Gly Ala 1 5 10 15 Asp Gly Val Gly Asn Ala Ser Gly
Asn Trp His Cys Asp Ser Thr Trp 20 25 30 Leu Gly Asp Arg Val Ile
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 35 40 45 Thr Tyr Asn Asn
His Leu Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly 50 55 60 Ala Ser
Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 65 70 75 80
Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 85
90 95 Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn
Phe 100 105 110 Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Thr Asn
Asp Gly Val 115 120 125 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val
Gln Val Phe Ser Asp 130 135 140 Ser Glu Tyr Gln Leu Pro Tyr Val Leu
Gly Ser Ala His Gln Gly Cys 145
150 155 160 Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr
Gly Tyr 165 170 175 Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg
Ser Ser Phe Tyr 180 185 190 Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu
Arg Thr Gly Asn Asn Phe 195 200 205 Thr Phe Ser Tyr Thr Phe Glu Glu
Val Pro Phe His Ser Ser Tyr Ala 210 215 220 His Ser Gln Ser Leu Asp
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr 225 230 235 240 Leu Tyr Tyr
Leu Asn Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn 245 250 255 Lys
Asp Leu Leu Phe Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln 260 265
270 Pro Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser
275 280 285 Lys Thr Lys Thr Asp Asn Asn Asn Ser Asn Phe Thr Trp Thr
Gly Ala 290 295 300 Ser Lys Tyr Asn Leu Asn Gly Arg Glu Ser Ile Ile
Asn Pro Gly Thr 305 310 315 320 Ala Met Ala Ser His Lys Asp Asp Glu
Asp Lys Phe Phe Pro Met Ser 325 330 335 Gly Val Met Ile Phe Gly Lys
Glu Ser Ala Gly Ala Ser Asn Thr Ala 340 345 350 Leu Asp Asn Val Met
Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn 355 360 365 Pro Val Ala
Thr Glu Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser 370 375 380 Ser
Ser Thr Asp Pro Ala Thr Gly Asp Val His Ala Met Gly Ala Leu 385 390
395 400 Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro
Ile 405 410 415 Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro
Ser Pro Leu 420 425 430 Met Gly Gly Phe Gly Leu Lys Asn Pro Pro Pro
Gln Ile Leu Ile Lys 435 440 445 Asn Thr Pro Val Pro Ala Asn Pro Pro
Ala Glu Phe Ser Ala Thr Lys 450 455 460 Phe Ala Ser Phe Ile Thr Gln
Tyr Ser Thr Gly Gln Val Ser Val Glu 465 470 475 480 Ile Glu Trp Glu
Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 485 490 495 Val Gln
Tyr Thr Ser Asn Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr 500 505 510
Val Asp Asn Asn Gly Leu Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg 515
520 525 Tyr Leu Thr Arg Pro Leu 530 184681DNAAAV-2 18ttggccactc
cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc 60cgacgcccgg
gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg
120gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat
tacgtcatag 180ggttagggag gtcctgtatt agaggtcacg tgagtgtttt
gcgacatttt gcgacaccat 240gtggtcacgc tgggtattta agcccgagtg
agcacgcagg gtctccattt tgaagcggga 300ggtttgaacg cgcagccgcc
atgccggggt tttacgagat tgtgattaag gtccccagcg 360accttgacgg
gcatctgccc ggcatttctg acagctttgt gaactgggtg gccgagaagg
420aatgggagtt gccgccagat tctgacatgg atctgaatct gattgagcag
gcacccctga 480ccgtggccga gaagctgcag cgcgactttc tgacggaatg
gcgccgtgtg agtaaggccc 540cggaggccct tttctttgtg caatttgaga
agggagagag ctacttccac atgcacgtgc 600tcgtggaaac caccggggtg
aaatccatgg ttttgggacg tttcctgagt cagattcgcg 660aaaaactgat
tcagagaatt taccgcggga tcgagccgac tttgccaaac tggttcgcgg
720tcacaaagac cagaaatggc gccggaggcg ggaacaaggt ggtggatgag
tgctacatcc 780ccaattactt gctccccaaa acccagcctg agctccagtg
ggcgtggact aatatggaac 840agtatttaag cgcctgtttg aatctcacgg
agcgtaaacg gttggtggcg cagcatctga 900cgcacgtgtc gcagacgcag
gagcagaaca aagagaatca gaatcccaat tctgatgcgc 960cggtgatcag
atcaaaaact tcagccaggt acatggagct ggtcgggtgg ctcgtggaca
1020aggggattac ctcggagaag cagtggatcc aggaggacca ggcctcatac
atctccttca 1080atgcggcctc caactcgcgg tcccaaatca aggctgcctt
ggacaatgcg ggaaagatta 1140tgagcctgac taaaaccgcc cccgactacc
tggtgggcca gcagcccgtg gaggacattt 1200ccagcaatcg gatttataaa
attttggaac taaacgggta cgatccccaa tatgcggctt 1260ccgtctttct
gggatgggcc acgaaaaagt tcggcaagag gaacaccatc tggctgtttg
1320ggcctgcaac taccgggaag accaacatcg cggaggccat agcccacact
gtgcccttct 1380acgggtgcgt aaactggacc aatgagaact ttcccttcaa
cgactgtgtc gacaagatgg 1440tgatctggtg ggaggagggg aagatgaccg
ccaaggtcgt ggagtcggcc aaagccattc 1500tcggaggaag caaggtgcgc
gtggaccaga aatgcaagtc ctcggcccag atagacccga 1560ctcccgtgat
cgtcacctcc aacaccaaca tgtgcgccgt gattgacggg aactcaacga
1620ccttcgaaca ccagcagccg ttgcaagacc ggatgttcaa atttgaactc
acccgccgtc 1680tggatcatga ctttgggaag gtcaccaagc aggaagtcaa
agactttttc cggtgggcaa 1740aggatcacgt ggttgaggtg gagcatgaat
tctacgtcaa aaagggtgga gccaagaaaa 1800gacccgcccc cagtgacgca
gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc 1860agccatcgac
gtcagacgcg gaagcttcga tcaactacgc agacaggtac caaaacaaat
1920gttctcgtca cgtgggcatg aatctgatgc tgtttccctg cagacaatgc
gagagaatga 1980atcagaattc aaatatctgc ttcactcacg gacagaaaga
ctgtttagag tgctttcccg 2040tgtcagaatc tcaaccggtt tctgtcgtca
aaaaggcgta tcagaaactg tgctacattc 2100atcatatcat gggaaaggtg
ccagacgctt gcactgcctg cgatctggtc aatgtggatt 2160tggatgactg
catctttgaa caataaatga tttaaatcag gtatggctgc cgatggttat
2220cttccagatt ggctcgagga cactctctct gaaggaataa gacagtggtg
gaagctcaaa 2280cctggcccac caccaccaaa gcccgcagag cggcataagg
acgacagcag gggtcttgtg 2340cttcctgggt acaagtacct cggacccttc
aacggactcg acaagggaga gccggtcaac 2400gaggcagacg ccgcggccct
cgagcacgac aaagcctacg accggcagct cgacagcgga 2460gacaacccgt
acctcaagta caaccacgcc gacgcggagt ttcaggagcg ccttaaagaa
2520gatacgtctt ttgggggcaa cctcggacga gcagtcttcc aggcgaaaaa
gagggttctt 2580gaacctctcg gcctggttga ggaacctgtt aagacggctc
cgggaaaaaa gaggccggta 2640gagcactctc ctgtggagcc agactcctcc
tcgggaaccg gaaagccggg ccagcagcct 2700gcaagaaaaa gattgaattt
tggtcagact ggagacgcag actcagtacc tgacccccag 2760cctctcggac
agccaccagc agccccctct ggtctgggaa ctaatacgat ggctacaggc
2820agtggcgcac caatggcaga caataacgag ggcgccgacg gagtgggtaa
ttcctccgga 2880aattggcatt gcgattccac atggatgggc gacagagtca
tcaccaccag cacccgaacc 2940tgggccctgc ccacctacaa caaccacctc
tacaaacaaa tttccagcca atcaggagcc 3000tcgaacgaca atcactactt
tggctacagc accccttggg ggtattttga cttcaacaga 3060ttccactgcc
acttttcacc acgtgactgg caaagactca tcaacaacaa ctggggattc
3120cgacccaaga gactcaactt caacctcttt aacattcaag tcaaagaggt
cacgcagaat 3180gacggtacga cgacgattgc caataacctt accagcacgg
ttcaggtgtt tactgactcg 3240gagtaccagc tcccgtacgt cctcggctcg
gcgcatcaag gatgcctccc gccgttccca 3300gcagacgtct tcatggtgcc
acagtatgga tacctcaccc tgaacaacgg gagtcaggca 3360gtaggacgct
cttcatttta ctgcctggag tactttcctt ctcagatgct gcgtaccgga
3420aacaacttta ccttcagcta cacttttgag gacgttcctt tccacagcag
ctacgctcac 3480agccagagtc tggaccgtct catgaatcct ctcatcgacc
agtacctgta ttacttgagc 3540agaacaaaca ctccaagtgg aaccaccacg
cagtcaaggc ttcagttttc tcaggcccca 3600gccagtgaca ttcgggacca
gtctaggaac tggcttcctg gaccctgtta ccgccagcag 3660cgagtatgaa
agacatctgc ggataacaac aacagtgaat actcgtggac tggagctacc
3720aagtaccacc tcaatggcag agactctctg gtgaatccgg ggcccgccat
ggcaagccac 3780aaggacgatg aagaaaagtt ttttcctcag agcggggttc
tcatctttgg gaagcaaggc 3840tcagagaaaa caaatgtgaa cattgaaaag
gtcatgatta cagacgaaga ggaaatccca 3900acaaccaatc ccgtggctac
ggagcagtat ggttctgtat ctaccaacct ccagagaggc 3960aacagacaag
cagctaccgc agatgtcaac acacaaggcg ttcttccagg catggtctgg
4020caggacagag atgtgtacct tcaggggccc atctgggcaa agattccaca
cacggacgga 4080cattttcacc cctctcccct catgggtgga ttcggactta
aacaccctcc tccacagatt 4140ctcatcaaga acaccccggt acctgcgaat
ccttcgacca ccttcagtgc ggcaaagttt 4200gcttccttca tcacacagta
ctccacggga cacggtcagc gtggagatcg agtgggagct 4260gcagaacgaa
aacagcaaac gctggaatcc cgaaattcag tacacttcca actacaacaa
4320gtctgttaat cgtggacttt accgtggata ctaatggcgt gtattcagag
cctcgcccca 4380ttggcaccag atacctgact cgtaatctgt aattgcttgt
taatcaataa accgtttaat 4440tcgtttcagt tgaactttgg tctctgcgta
tttctttctt atctagtttc catggctacg 4500tagataagta gcatggcggg
ttaatcatta actacaagga acccctagtg atggagttgg 4560ccactccctc
tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac
4620gcccgggctt tgccccggcg gcctcagtga gcgagcgagc gcgcagagag
ggagtgggca 4680a 4681194683DNAAAV-6 19ttggccactc cctctctgcg
cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc 60cgacgcccgg gctttgcccg
ggcggcctca gtgagcgagc gagcgcgcag agagggagtg 120gccaactcca
tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag
180ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt
gcgacaccat 240gtggtcacgc tgggtattta agcccgagtg agcacgcagg
gtctccattt tgaagcggga 300ggtttgaacg cgcagcgcca tgccggggtt
ttacgagatt gtgattaagg tccccagcga 360ccttgacgag catctgcccg
gcatttctga cagctttgtg aactgggtgg ccgagaagga 420atgggagttg
ccgccagatt ctgacatgga tctgaatctg attgagcagg cacccctgac
480cgtggccgag aagctgcagc gcgacttcct ggtccactgg cgccgcgtga
gtaaggcccc 540ggaggccctc ttctttgttc agttcgagaa gggcgagtcc
tacttccacc tccatattct 600ggtggagacc acgggggtca aatccatggt
gctgggccgc ttcctgagtc agattagcga 660caagctggtg cagaccatct
accgcgggat cgagccgacc ctgcccaact ggttcgcggt 720gaccaagacg
cgtaatggcg ccggaggggg gaacaaggtg gtggacgagt gctacatccc
780caactacctc ctgcccaaga ctcagcccga gctgcagtgg gcgtggacta
acatggagga 840gtatataagc gcgtgtttaa acctggccga gcgcaaacgg
ctcgtggcgc acgacctgac 900ccacgtcagc cagacccagg agcagaacaa
ggagaatctg aaccccaatt ctgacgcgcc 960tgtcatccgg tcaaaaacct
ccgcacgcta catggagctg gtcgggtggc tggtggaccg 1020gggcatcacc
tccgagaagc agtggatcca ggaggaccag gcctcgtaca tctccttcaa
1080cgccgcctcc aactcgcggt cccagatcaa ggccgctctg gacaatgccg
gcaagatcat 1140ggcgctgacc aaatccgcgc ccgactacct ggtaggcccc
gctccgcccg ccgacattaa 1200aaccaaccgc atttaccgca tcctggagct
gaacggctac gaccctgcct acgccggctc 1260cgtctttctc ggctgggccc
agaaaaggtt cggaaaacgc aacaccatct ggctgtttgg 1320gccggccacc
acgggcaaga ccaacatcgc ggaagccatc gcccacgccg tgcccttcta
1380cggctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg
acaagatggt 1440gatctggtgg gaggagggca agatgacggc caaggtcgtg
gagtccgcca aggccattct 1500cggcggcagc aaggtgcgcg tggaccaaaa
gtgcaagtcg tccgcccaga tcgatcccac 1560ccccgtgatc gtcacctcca
acaccaacat gtgcgccgtg attgacggga acagcaccac 1620cttcgagcac
cagcagccgt tgcaggaccg gatgttcaaa tttgaactca cccgccgtct
1680ggagcatgac tttggcaagg tgacaaagca ggaagtcaaa gagttcttcc
gctgggcgca 1740ggatcacgtg accgaggtgg cgcatgagtt ctacgtcaga
aagggtggag ccaacaacag 1800acccgccccc gatgacgcgg ataaaagcga
gcccaagcgg gcctgcccct cagtcgcgga 1860tccatcgacg tcagacgcgg
aaggagctcc ggtggacttt gccgacaggt accaaaacaa 1920atgttctcgt
cacgcgggca tgcttcagat gctgtttccc tgcaaaacat gcgagagaat
1980gaatcagaat ttcaacattt gcttcacgca cgggaccaga gactgttcag
aatgtttccc 2040cggcgtgtca gaatctcaac cggtcgtcag aaagaggacg
tatcggaaac tctgtgccat 2100tcatcatctg ctggggcggg ctcccgagat
tgcttgctcg gcctgcgatc tggtcaacgt 2160ggatctggat gactgtgttt
ctgagcaata aatgacttaa accaggtatg gctgccgatg 2220gttatcttcc
agattggctc gaggacaacc tctctgaggg cattcggcag tggtgggact
2280tgaaacctgg agccccgaaa cccaaagcca accagcaaaa gcaggacgac
ggccggggtc 2340tggtgcttcc tggctacaag tacctcggac ccttcaacgg
actcgacaag ggggagcccg 2400tcaacgcggc ggatgcagcg gccctcgagc
acgacaaggc ctacgaccag cagctcaaag 2460cgggtgacaa tccgtacctg
cggtataacc acgccgacgc cgagtttcag gagcgtctgc 2520aagaagatac
gtcttttggg ggcaacctcg ggcgagcagt cttccaggcc aagaagaggg
2580ttctcgaacc ttttggtctg gttgaggaag gtgctaagac ggctcctgga
aagaaacgtc 2640cggtagagca gtcgccacaa gagccagact cctcctcggg
cattggcaag acaggccagc 2700agcccgctaa aaagagactc aattttggtc
agactggcga ctcagagtca gtccccgacc 2760cacaacctct cggagaacct
ccagcaaccc ccgctgctgt gggacctact acaatggctt 2820caggcggtgg
cgcaccaatg gcagacaata acgaaggcgc cgacggagtg ggtaatgcct
2880caggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc
accagcaccc 2940gaacatgggc cttgcccacc tataacaacc acctctacaa
gcaaatctcc agtgcttcaa 3000cgggggccag caacgacaac cactacttcg
gctacagcac cccctggggg tattttgatt 3060tcaacagatt ccactgccat
ttctcaccac gtgactggca gcgactcatc aacaacaatt 3120ggggattccg
gcccaagaga ctcaacttca agctcttcaa catccaagtc aaggaggtca
3180cgacgaatga tggcgtcacg accatcgcta ataaccttac cagcacggtt
caagtcttgt 3240cggactcgga gtaccagttc ccgtacgtcc tcggctctgc
gcaccagggc tgcctccctc 3300cgttcccggc ggacgtgttc atgattccgc
agtacggcta cctaacgctc aacaatggca 3360gccaggcagt gggacgctca
tccttttact gcctggaata tttcccatcg cagatgctga 3420gaacgggcaa
taactttacc ttcagctaca ccttcgagga cgtgcctttc cacagcagct
3480acgcgcacag ccagagcctg gaccggctga tgaatcctct catcgaccag
tacctgtatt 3540acctgaacag aactcacaat cagtccggaa gtgcccaaaa
caaggacttg ctgtttagcc 3600gtgggtctcc agctggcatg tctgttcagc
ccaaaaactg gctacctgga ccctgttacc 3660ggcagcagcg cgtttctaaa
acaaaaacag acaacaacaa cagcaacttt acctggactg 3720gtgcttcaaa
atataacctt aatgggcgtg aatctataat caaccctggc actgctatgg
3780cctcacacaa agacgacaaa gacaagttct ttcccatgag cggtgtcatg
atttttggaa 3840aggagagcgc cggagcttca aacactgcat tggacaatgt
catgatcaca gacgaagagg 3900aaatcaaagc cactaacccc gtggccaccg
aaagatttgg gactgtggca gtcaatctcc 3960agagcagcag cacagaccct
gcgaccggag atgtgcatgt tatgggagcc ttacctggaa 4020tggtgtggca
agacagagac gtatacctgc agggtcctat ttgggccaaa attcctcaca
4080cggatggaca ctttcacccg tctcctctca tgggcggctt tggacttaag
cacccgcctc 4140ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc
tccggcagag ttttcggcta 4200caaagtttgc ttcattcatc acccagtatt
ccacaggaca agtgagcgtg gagattgaat 4260gggagctgca gaaagaaaac
agcaaacgct ggaatcccga agtgcagtat acatctaact 4320atgcaaaatc
tgccaacgtt gatttcactg tggacaacaa tggactttat actgagcctc
4380gccccattgg cacccgttac ctcacccgtc ccctgtaatt gtgtgttaat
caataaaccg 4440gttaattcgt gtcagttgaa ctttggtctc atgtccttat
tatcttatct ggtcaccata 4500gcaaccggtt acacattaac tgcttagttg
cgcttcgcga atacccctag tgatggagtt 4560gcccactccc tctatgcgcg
ctcgctcgct cggtggggcc ggcagagcag agctctgccg 4620tctgcggacc
tttggtccgc aggccccacc gagcgagcga gcgcgcatag agggagtggc 4680caa
46832016DNArep binding motif 20gctcgctcgc tcgctg 16
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