U.S. patent application number 15/330876 was filed with the patent office on 2017-07-13 for engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation. The applicant listed for this patent is THE BROAD INSTITUTE INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE. Invention is credited to Fei Ran, Ophir Shalem, Feng Zhang.
Application Number | 20170198269 15/330876 |
Document ID | / |
Family ID | 49883291 |
Filed Date | 2017-07-13 |
United States Patent Application | 20170198269 |
Kind Code | A1 |
Zhang; Feng ; et al. | July 13, 2017 |
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme.
Inventors: | Zhang; Feng; (Cambridge, MA) ; Ran; Fei; (Boston, MA) ; Shalem; Ophir; (Albany, CA) | ||||||||||
Applicant: |
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Family ID: | 49883291 | ||||||||||
Appl. No.: | 15/330876 | ||||||||||
Filed: | November 7, 2016 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
14104977 | Dec 12, 2013 | |||
15330876 | ||||
61748427 | Jan 2, 2013 | |||
61758468 | Jan 30, 2013 | |||
61769046 | Feb 25, 2013 | |||
61791409 | Mar 15, 2013 | |||
61802174 | Mar 15, 2013 | |||
61806375 | Mar 28, 2013 | |||
61814263 | Apr 20, 2013 | |||
61819803 | May 6, 2013 | |||
61828130 | May 28, 2013 | |||
61835931 | Jun 17, 2013 | |||
61836101 | Jun 17, 2013 | |||
61736527 | Dec 12, 2012 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | C12N 9/22 20130101; C12N 9/96 20130101; C12N 15/907 20130101; C12N 2810/10 20130101; C12N 15/1082 20130101; C12N 15/86 20130101; C12N 2800/22 20130101; C12N 15/63 20130101; A61P 27/02 20180101; A61K 48/00 20130101; C12N 15/8213 20130101; C12N 15/85 20130101; C12N 2750/14143 20130101 |
International Class: | C12N 9/22 20060101 C12N009/22; C12N 15/90 20060101 C12N015/90; C12N 15/82 20060101 C12N015/82; C12N 9/96 20060101 C12N009/96; C12N 15/86 20060101 C12N015/86 |
Sequence CWU 1
1
228120DNAHomo sapiens 1gagtccgagc agaagaagaa 20220DNAHomo sapiens
2gagtcctagc aggagaagaa 20320DNAHomo sapiens 3gagtctaagc agaagaagaa
20460RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 4nnnnnnnnnn nnnnnnnnnn ccnnnnnnnn
nnnnnnnnnn nnnnggnnnn nnnnnnnnnn 60560RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 5nnnnnnnnnn nnnnccnnnn nnnnnnnnnn nnnnnnnngg
nnnnnnnnnn nnnnnnnnnn 60660RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 6nnnnnnnnnn
nnnnnnnnnn ccnnnnnnnn nnnnnnnnnn nnnggnnnnn nnnnnnnnnn
60760RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 7nnnnnnnnnn nnnnnccnnn nnnnnnnnnn
nnnnnnnngg nnnnnnnnnn nnnnnnnnnn 60860RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 8nnnnnnnnnn nnnnnnnnnn ccnnnnnnnn nnnnnnnnnn
nnggnnnnnn nnnnnnnnnn 60960RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 9nnnnnnnnnn
nnnnnccnnn nnnnnnnnnn nnnnnnnngg nnnnnnnnnn nnnnnnnnnn
601060RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 10nnnnnnnnnn nnnnnnnnnn ccnnnnnnnn
nnnnnnnnnn nggnnnnnnn nnnnnnnnnn 601160RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 11nnnnnnnnnn nnnnnnnccn nnnnnnnnnn nnnnnnnngg
nnnnnnnnnn nnnnnnnnnn 601260RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 12nnnnnnnnnn
nnnnnnnnnn ccnnnnnnnn nnnnnnnnnn ggnnnnnnnn nnnnnnnnnn
601360RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 13nnnnnnnnnn nnnnnnnncc nnnnnnnnnn
nnnnnnnngg nnnnnnnnnn nnnnnnnnnn 601460RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 14nnnnnnnnnn nnnnnnnnnn ccnnnnnnnn nnnnnnnnng
gnnnnnnnnn nnnnnnnnnn 601560RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 15nnnnnnnnnn
nnnnnnnnnc cnnnnnnnnn nnnnnnnngg nnnnnnnnnn nnnnnnnnnn
601660RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 16nnnnnnnnnn nnnnnnnnnn ccnnnnnnnn
nnnnnnnngg nnnnnnnnnn nnnnnnnnnn 601760RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 17nnnnnnnnnn nnnnnnnnnn ccnnnnnnnn nnnnnnnngg
nnnnnnnnnn nnnnnnnnnn 601860RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 18nnnnnnnnnn
nnnnnnnnnn ccnnnnnnnn nnnnnnnggn nnnnnnnnnn nnnnnnnnnn
601960RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 19nnnnnnnnnn nnnnnnnnnn nccnnnnnnn
nnnnnnnngg nnnnnnnnnn nnnnnnnnnn 602060RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 20nnnnnnnnnn nnnnnnnnnn ccnnnnnnnn nnnnnnggnn
nnnnnnnnnn nnnnnnnnnn 602160RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 21nnnnnnnnnn
nnnnnnnnnn nnccnnnnnn nnnnnnnngg nnnnnnnnnn nnnnnnnnnn
602260RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 22nnnnnnnnnn nnnnnnnnnn ccnnnnnnnn
nnnnnggnnn nnnnnnnnnn nnnnnnnnnn 602360RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 23nnnnnnnnnn nnnnnnnnnn nnnccnnnnn nnnnnnnngg
nnnnnnnnnn nnnnnnnnnn 602460RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 24nnnnnnnnnn
nnnnnnnnnn ccnnnnnnnn nnnnggnnnn nnnnnnnnnn nnnnnnnnnn
602560RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 25nnnnnnnnnn nnnnnnnnnn nnnnccnnnn
nnnnnnnngg nnnnnnnnnn nnnnnnnnnn 602660RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 26nnnnnnnnnn nnnnnnnnnn ccnnnnnnnn nnnggnnnnn
nnnnnnnnnn nnnnnnnnnn 602760RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 27nnnnnnnnnn
nnnnnnnnnn nnnnnccnnn nnnnnnnngg nnnnnnnnnn nnnnnnnnnn
602860RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 28nnnnnnnnnn nnnnnnnnnn ccnnnnnnnn
nnggnnnnnn nnnnnnnnnn nnnnnnnnnn 602960RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 29nnnnnnnnnn nnnnnnnnnn nnnnnnccnn nnnnnnnngg
nnnnnnnnnn nnnnnnnnnn 603060RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 30nnnnnnnnnn
nnnnnnnnnn ccnnnnnnnn nggnnnnnnn nnnnnnnnnn nnnnnnnnnn
603160RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 31nnnnnnnnnn nnnnnnnnnn nnnnnnnccn
nnnnnnnngg nnnnnnnnnn nnnnnnnnnn 603260RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 32nnnnnnnnnn nnnnnnnnnn ccnnnnnnnn ggnnnnnnnn
nnnnnnnnnn nnnnnnnnnn 603360RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 33nnnnnnnnnn
nnnnnnnnnn nnnnnnnncc nnnnnnnngg nnnnnnnnnn nnnnnnnnnn
603460RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 34nnnnnnnnnn nnnnnnnnnn ccnnnnnnng
gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 603560RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 35nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc cnnnnnnngg
nnnnnnnnnn nnnnnnnnnn 603660RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 36nnnnnnnnnn
nnnnnnnnnn ccnnnnnngg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
603760RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 37nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
ccnnnnnngg nnnnnnnnnn nnnnnnnnnn 603860RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 38nnnnnnnnnn nnnnnnnnnn ccnnnnnggn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn 603960RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 39nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nccnnnnngg nnnnnnnnnn nnnnnnnnnn
604060RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 40nnnnnnnnnn nnnnnnnnnn ccnnnnggnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 604160RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 41nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnccnnnngg
nnnnnnnnnn nnnnnnnnnn 604260RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 42nnnnnnnnnn
nnnnnnnnnn ccnnnggnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
604360RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 43nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnccnnngg nnnnnnnnnn nnnnnnnnnn 604460RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 44nnnnnnnnnn nnnnnnnnnn ccnnggnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn 604560RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 45nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnccnngg nnnnnnnnnn nnnnnnnnnn
604660RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 46nnnnnnnnnn nnnnnnnnnn ccnggnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 604760RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 47nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnccngg
nnnnnnnnnn nnnnnnnnnn 604860RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 48nnnnnnnnnn
nnnnnnnnnn nccggnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
604960RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 49nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
nnnnnccggn nnnnnnnnnn nnnnnnnnnn 605060RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 50nnnnnnnnnn nnnnnnnnnn nnnggnnnnn nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn 605160RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 51nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nnnggccnnn nnnnnnnnnn nnnnnnnnnn
605260RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 52nnnnnnnnnn nnnnnnnnnn nncggnnnnn
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 605360RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 53nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnggnccnnn
nnnnnnnnnn nnnnnnnnnn 605460RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 54nnnnnnnnnn
nnnnnnnnnn nnnnnnnnnn nggnnccnnn nnnnnnnnnn nnnnnnnnnn
605560RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 55nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
ggnnnccnnn nnnnnnnnnn nnnnnnnnnn 605660RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 56nnnnnnnnnn nnnnnnnnnn nnnnnnnnng gnnnnccnnn
nnnnnnnnnn nnnnnnnnnn 605760RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 57nnnnnnnnnn
nnnnnnnnnn nnnnnnnngg nnnnnccnnn nnnnnnnnnn nnnnnnnnnn
605812RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 58guuuuagagc ua 12597PRTSimian virus 40
59Pro Lys Lys Lys Arg Lys Val 1 5 6016PRTUnknownDescription of
Unknown Nucleoplasmin bipartite NLS sequence 60Lys Arg Pro Ala Ala
Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 1 5 10 15
619PRTUnknownDescription of Unknown C-myc NLS sequence 61Pro Ala
Ala Lys Arg Val Lys Leu Asp 1 5 6211PRTUnknownDescription of
Unknown C-myc NLS sequence 62Arg Gln Arg Arg Asn Glu Leu Lys Arg
Ser Pro 1 5 10 6338PRTHomo sapiens 63Asn Gln Ser Ser Asn Phe Gly
Pro Met Lys Gly Gly Asn Phe Gly Gly 1 5 10 15 Arg Ser Ser Gly Pro
Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 20 25 30 Arg Asn Gln
Gly Gly Tyr 35 6442PRTUnknownDescription of Unknown IBB domain from
importin-alpha sequence 64Arg Met Arg Ile Glx Phe Lys Asn Lys Gly
Lys Asp Thr Ala Glu Leu 1 5 10 15 Arg Arg Arg Arg Val Glu Val Ser
Val Glu Leu Arg Lys Ala Lys Lys 20 25 30 Asp Glu Gln Ile Leu Lys
Arg Arg Asn Val 35 40 658PRTUnknownDescription of Unknown Myoma T
protein sequence 65Val Ser Arg Lys Arg Pro Arg Pro 1 5
668PRTUnknownDescription of Unknown Myoma T protein sequence 66Pro
Pro Lys Lys Ala Arg Glu Asp 1 5 678PRTHomo sapiens 67Pro Gln Pro
Lys Lys Lys Pro Leu 1 5 6812PRTMus musculus 68Ser Ala Leu Ile Lys
Lys Lys Lys Lys Met Ala Pro 1 5 10 695PRTInfluenza virus 69Asp Arg
Leu Arg Arg 1 5 707PRTInfluenza virus 70Pro Lys Gln Lys Lys Arg Lys
1 5 7110PRTHepatitus delta virus 71Arg Lys Leu Lys Lys Lys Ile Lys
Lys Leu 1 5 10 7210PRTMus musculus 72Arg Glu Lys Lys Lys Phe Leu
Lys Arg Arg 1 5 10 7320PRTHomo sapiens 73Lys Arg Lys Gly Asp Glu
Val Asp Gly Val Asp Glu Val Ala Lys Lys 1 5 10 15 Lys Ser Lys Lys
20 7417PRTHomo sapiens 74Arg Lys Cys Leu Gln Ala Gly Met Asn Leu
Glu Ala Arg Lys Thr Lys 1 5 10 15 Lys 75137DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
75nnnnnnnnnn nnnnnnnnnn gtttttgtac tctcaagatt tagaaataaa tcttgcagaa
60gctacaaaga taaggcttca tgccgaaatc aacaccctgt cattttatgg cagggtgttt
120tcgttattta atttttt 13776123DNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotide 76nnnnnnnnnn
nnnnnnnnnn gtttttgtac tctcagaaat gcagaagcta caaagataag 60gcttcatgcc
gaaatcaaca ccctgtcatt ttatggcagg gtgttttcgt tatttaattt 120ttt
12377110DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 77nnnnnnnnnn nnnnnnnnnn gtttttgtac
tctcagaaat gcagaagcta caaagataag 60gcttcatgcc gaaatcaaca ccctgtcatt
ttatggcagg gtgttttttt 11078102DNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotide 78nnnnnnnnnn
nnnnnnnnnn gttttagagc tagaaatagc aagttaaaat aaggctagtc 60cgttatcaac
ttgaaaaagt ggcaccgagt cggtgctttt tt 1027988DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 79nnnnnnnnnn nnnnnnnnnn gttttagagc tagaaatagc
aagttaaaat aaggctagtc 60cgttatcaac ttgaaaaagt gttttttt
888076DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 80nnnnnnnnnn nnnnnnnnnn gttttagagc
tagaaatagc aagttaaaat aaggctagtc 60cgttatcatt tttttt
7681984PRTCampylobacter jejuni 81Met Ala Arg Ile Leu Ala Phe Asp
Ile Gly Ile Ser Ser Ile Gly Trp 1 5 10 15 Ala Phe Ser Glu Asn Asp
Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Val Glu
Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu
Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60
Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65
70 75 80 Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr
Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala
Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gln Asp Phe Ala Arg Val Ile
Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn
Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys
Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 145 150 155 160 Ser Val Gly
Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 165 170 175 Asn
Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185
190 Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe
195 200 205 Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe
Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu
Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe
Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe
Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn
Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu
Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr
Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310
315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr
Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln
Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys
Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu
Asn Gln Asn Gln Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys
Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Val
Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys
Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430
Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435
440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu
Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn
Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gln
Arg Ala Lys Ile Glu Lys
485 490 495 Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu
Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile
Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala
Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gln Asp Glu
Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg
Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr
Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 580 585 590 Ala
Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 595 600
605 Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr
610 615 620 Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn
Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr
Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn
Thr Lys Leu Asn Asp Thr Gln 660 665 670 Lys Gly Ser Lys Val His Val
Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr
Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His
Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720
Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 725
730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn
Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys
Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu
Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg
Lys Glu Glu Glu Phe Tyr Gln 785 790 795 800 Ser Tyr Gly Gly Lys Glu
Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val
Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp
Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845
Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850
855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp
Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser
Leu Ile Leu Ile 885 890 895 Gln Thr Lys Asp Met Gln Glu Pro Glu Phe
Val Tyr Tyr Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile
Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Thr Leu Ser Lys Asn
Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 930 935 940 Lys Glu Val Ile
Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 945 950 955 960 Glu
Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 965 970
975 Arg Gln Arg Glu Asp Phe Lys Lys 980 8291DNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 82tataatctca taagaaattt aaaaagggac taaaataaag
agtttgcggg actctgcggg 60gttacaatcc cctaaaaccg cttttaaaat t
918336DNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 83gttttagtcc ctttttaaat ttctttatgg taaaat
368495RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 84nnnnnnnnnn nnnnnnnnnn guuuuagucc
cgaaagggac uaaaauaaag aguuugcggg 60acucugcggg guuacaaucc ccuaaaaccg
cuuuu 95853243DNAArtificial SequenceDescription of Artificial
Sequence Synthetic polynucleotide 85accggtgcca ccatgtaccc
atacgatgtt ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag cgtccatgaa
aaggaactac attctggggc tggacatcgg gattacaagc 120gtggggtatg
ggattattga ctatgaaaca agggacgtga tcgacgcagg cgtcagactg
180ttcaaggagg ccaacgtgga aaacaatgag ggacggagaa gcaagagggg
agccaggcgc 240ctgaaacgac ggagaaggca cagaatccag agggtgaaga
aactgctgtt cgattacaac 300ctgctgaccg accattctga gctgagtgga
attaatcctt atgaagccag ggtgaaaggc 360ctgagtcaga agctgtcaga
ggaagagttt tccgcagctc tgctgcacct ggctaagcgc 420cgaggagtgc
ataacgtcaa tgaggtggaa gaggacaccg gcaacgagct gtctacaaag
480gaacagatct cacgcaatag caaagctctg gaagagaagt atgtcgcaga
gctgcagctg 540gaacggctga agaaagatgg cgaggtgaga gggtcaatta
ataggttcaa gacaagcgac 600tacgtcaaag aagccaagca gctgctgaaa
gtgcagaagg cttaccacca gctggatcag 660agcttcatcg atacttatat
cgacctgctg gagactcgga gaacctacta tgagggacca 720ggagaaggga
gccccttcgg atggaaagac atcaaggaat ggtacgagat gctgatggga
780cattgcacct attttccaga agagctgaga agcgtcaagt acgcttataa
cgcagatctg 840tacaacgccc tgaatgacct gaacaacctg gtcatcacca
gggatgaaaa cgagaaactg 900gaatactatg agaagttcca gatcatcgaa
aacgtgttta agcagaagaa aaagcctaca 960ctgaaacaga ttgctaagga
gatcctggtc aacgaagagg acatcaaggg ctaccgggtg 1020acaagcactg
gaaaaccaga gttcaccaat ctgaaagtgt atcacgatat taaggacatc
1080acagcacgga aagaaatcat tgagaacgcc gaactgctgg atcagattgc
taagatcctg 1140actatctacc agagctccga ggacatccag gaagagctga
ctaacctgaa cagcgagctg 1200acccaggaag agatcgaaca gattagtaat
ctgaaggggt acaccggaac acacaacctg 1260tccctgaaag ctatcaatct
gattctggat gagctgtggc atacaaacga caatcagatt 1320gcaatcttta
accggctgaa gctggtccca aaaaaggtgg acctgagtca gcagaaagag
1380atcccaacca cactggtgga cgatttcatt ctgtcacccg tggtcaagcg
gagcttcatc 1440cagagcatca aagtgatcaa cgccatcatc aagaagtacg
gcctgcccaa tgatatcatt 1500atcgagctgg ctagggagaa gaacagcaag
gacgcacaga agatgatcaa tgagatgcag 1560aaacgaaacc ggcagaccaa
tgaacgcatt gaagagatta tccgaactac cgggaaagag 1620aacgcaaagt
acctgattga aaaaatcaag ctgcacgata tgcaggaggg aaagtgtctg
1680tattctctgg aggccatccc cctggaggac ctgctgaaca atccattcaa
ctacgaggtc 1740gatcatatta tccccagaag cgtgtccttc gacaattcct
ttaacaacaa ggtgctggtc 1800aagcaggaag agaactctaa aaagggcaat
aggactcctt tccagtacct gtctagttca 1860gattccaaga tctcttacga
aacctttaaa aagcacattc tgaatctggc caaaggaaag 1920ggccgcatca
gcaagaccaa aaaggagtac ctgctggaag agcgggacat caacagattc
1980tccgtccaga aggattttat taaccggaat ctggtggaca caagatacgc
tactcgcggc 2040ctgatgaatc tgctgcgatc ctatttccgg gtgaacaatc
tggatgtgaa agtcaagtcc 2100atcaacggcg ggttcacatc ttttctgagg
cgcaaatgga agtttaaaaa ggagcgcaac 2160aaagggtaca agcaccatgc
cgaagatgct ctgattatcg caaatgccga cttcatcttt 2220aaggagtgga
aaaagctgga caaagccaag aaagtgatgg agaaccagat gttcgaagag
2280aagcaggccg aatctatgcc cgaaatcgag acagaacagg agtacaagga
gattttcatc 2340actcctcacc agatcaagca tatcaaggat ttcaaggact
acaagtactc tcaccgggtg 2400gataaaaagc ccaacagaga gctgatcaat
gacaccctgt atagtacaag aaaagacgat 2460aaggggaata ccctgattgt
gaacaatctg aacggactgt acgacaaaga taatgacaag 2520ctgaaaaagc
tgatcaacaa aagtcccgag aagctgctga tgtaccacca tgatcctcag
2580acatatcaga aactgaagct gattatggag cagtacggcg acgagaagaa
cccactgtat 2640aagtactatg aagagactgg gaactacctg accaagtata
gcaaaaagga taatggcccc 2700gtgatcaaga agatcaagta ctatgggaac
aagctgaatg cccatctgga catcacagac 2760gattacccta acagtcgcaa
caaggtggtc aagctgtcac tgaagccata cagattcgat 2820gtctatctgg
acaacggcgt gtataaattt gtgactgtca agaatctgga tgtcatcaaa
2880aaggagaact actatgaagt gaatagcaag tgctacgaag aggctaaaaa
gctgaaaaag 2940attagcaacc aggcagagtt catcgcctcc ttttacaaca
acgacctgat taagatcaat 3000ggcgaactgt atagggtcat cggggtgaac
aatgatctgc tgaaccgcat tgaagtgaat 3060atgattgaca tcacttaccg
agagtatctg gaaaacatga atgataagcg cccccctcga 3120attatcaaaa
caattgcctc taagactcag agtatcaaaa agtactcaac cgacattctg
3180ggaaacctgt atgaggtgaa gagcaaaaag caccctcaga ttatcaaaaa
gggctaagaa 3240ttc 3243861115PRTArtificial SequenceDescription of
Artificial Sequence Synthetic polypeptide 86Met Ser Asp Leu Val Leu
Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 1 5 10 15 Val Gly Ile Leu
Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 20 25 30 Arg Ile
Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 35 40 45
Asn Arg Gln Gly Arg Arg Leu Ala Arg Arg Lys Lys His Arg Arg Val 50
55 60 Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe
Thr 65 70 75 80 Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val
Lys Gly Leu 85 90 95 Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile
Ala Leu Lys Asn Met 100 105 110 Val Lys His Arg Gly Ile Ser Tyr Leu
Asp Asp Ala Ser Asp Asp Gly 115 120 125 Asn Ser Ser Val Gly Asp Tyr
Ala Gln Ile Val Lys Glu Asn Ser Lys 130 135 140 Gln Leu Glu Thr Lys
Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 145 150 155 160 Thr Tyr
Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 165 170 175
Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 180
185 190 Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile
Thr 195 200 205 Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly
Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg
Thr Asp Tyr Gly Arg 225 230 235 240 Tyr Arg Thr Ser Gly Glu Thr Leu
Asp Asn Ile Phe Gly Ile Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr
Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 260 265 270 Tyr Thr Ala Gln
Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro
Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 290 295 300
Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 305
310 315 320 Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile
Lys Gly 325 330 335 Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His
Thr Phe Glu Ala 340 345 350 Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu
Asp Ile Glu Gln Met Asp 355 360 365 Arg Glu Thr Leu Asp Lys Leu Ala
Tyr Val Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Gln Glu
Ala Leu Glu His Glu Phe Ala Asp Gly Ser 385 390 395 400 Phe Ser Gln
Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 405 410 415 Ser
Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 420 425
430 Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr
435 440 445 Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser
Asn Lys 450 455 460 Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu
Ile Tyr Asn Pro 465 470 475 480 Val Val Ala Lys Ser Val Arg Gln Ala
Ile Lys Ile Val Asn Ala Ala 485 490 495 Ile Lys Glu Tyr Gly Asp Phe
Asp Asn Ile Val Ile Glu Met Ala Arg 500 505 510 Glu Asn Gln Thr Thr
Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 515 520 525 Lys Arg Ile
Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 530 535 540 Glu
His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 545 550
555 560 Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu
Asp 565 570 575 Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val
Pro Gln Ser 580 585 590 Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val
Leu Thr Arg Ser Asp 595 600 605 Lys Asn Arg Gly Lys Ser Asp Asn Val
Pro Ser Glu Glu Val Val Lys 610 615 620 Lys Met Lys Asn Tyr Trp Arg
Gln Leu Leu Asn Ala Lys Leu Ile Thr 625 630 635 640 Gln Arg Lys Phe
Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 645 650 655 Glu Leu
Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 660 665 670
Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 675
680 685 Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile
Thr 690 695 700 Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe
Gln Phe Tyr 705 710 715 720 Lys Val Arg Glu Ile Asn Asn Tyr His His
Ala His Asp Ala Tyr Leu 725 730 735 Asn Ala Val Val Gly Thr Ala Leu
Ile Lys Lys Tyr Pro Lys Leu Glu 740 745 750 Ser Glu Phe Val Tyr Gly
Asp Tyr Lys Val Tyr Asp Val Arg Lys Met 755 760 765 Ile Ala Lys Ser
Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe 770 775 780 Phe Tyr
Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 785 790 795
800 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr
805 810 815 Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val
Arg Lys 820 825 830 Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys
Thr Glu Val Gln 835 840 845 Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu
Pro Lys Arg Asn Ser Asp 850 855 860 Lys Leu Ile Ala Arg Lys Lys Asp
Trp Asp Pro Lys Lys Tyr Gly Gly 865 870 875 880 Phe Asp Ser Pro Thr
Val Ala Tyr Ser Val Leu Val Val Ala Lys Val 885 890 895 Glu Lys Gly
Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly 900 905 910 Ile
Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe 915 920
925 Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys
930 935 940 Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys
Arg Met 945 950 955 960 Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn
Glu Leu Ala Leu Pro 965 970 975 Ser Lys Tyr Val Asn Phe Leu Tyr Leu
Ala Ser His Tyr Glu Lys Leu 980 985 990 Lys Gly Ser Pro Glu Asp Asn
Glu Gln Lys Gln Leu Phe Val Glu Gln 995 1000 1005 His Lys His Tyr
Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe 1010 1015 1020 Ser Lys
Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu 1025 1030 1035
Ser Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala 1040
1045 1050 Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala
Pro 1055 1060 1065 Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg
Lys Arg Tyr 1070 1075 1080 Thr Ser Thr Lys Glu Val Leu Asp Ala Thr
Leu Ile His Gln Ser 1085 1090 1095 Ile Thr Gly Leu Tyr Glu Thr Arg
Ile Asp Leu Ser Gln Leu Gly 1100 1105 1110 Gly Asp 1115
871374PRTArtificial SequenceDescription of Artificial Sequence
Synthetic polypeptide 87Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile
Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr
Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp
Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe
Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr
Ala Arg Arg
Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu
Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe
His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110
His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115
120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val
Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala
Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile
Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu
Phe Ile Gln Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu Glu
Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu
Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile
Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235
240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe
245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr
Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp
Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp
Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile
Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr
Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val
Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp
Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360
365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp
370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu
Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro
His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg
Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys
Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly
Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg
Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480
Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485
490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His
Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr
Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe
Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe
Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys Glu
Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile
Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr
His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605
Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610
615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr
Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys
Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu
Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile Leu
Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met
Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile
Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720 His
Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730
735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly
740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu
Thr Asn 755 760 765 Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln
Lys Ala Asn Lys 770 775 780 Asp Glu Lys Asp Ala Ala Met Leu Lys Ala
Ala Asn Gln Tyr Asn Gly 785 790 795 800 Lys Ala Glu Leu Pro His Ser
Val Phe His Gly His Lys Gln Leu Ala 805 810 815 Thr Lys Ile Arg Leu
Trp His Gln Gln Gly Glu Arg Cys Leu Tyr Thr 820 825 830 Gly Lys Thr
Ile Ser Ile His Asp Leu Ile Asn Asn Ser Asn Gln Phe 835 840 845 Glu
Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp Asp Ser Leu 850 855
860 Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu Lys Gly Gln
865 870 875 880 Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala
Trp Ser Phe 885 890 895 Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys
Thr Leu Ser Asn Lys 900 905 910 Lys Lys Glu Tyr Leu Leu Thr Glu Glu
Asp Ile Ser Lys Phe Asp Val 915 920 925 Arg Lys Lys Phe Ile Glu Arg
Asn Leu Val Asp Thr Arg Tyr Ala Ser 930 935 940 Arg Val Val Leu Asn
Ala Leu Gln Glu His Phe Arg Ala His Lys Ile 945 950 955 960 Asp Thr
Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser Gln Leu Arg 965 970 975
Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His His His Ala 980
985 990 Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn Leu Trp
Lys 995 1000 1005 Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp
Gln Leu Leu 1010 1015 1020 Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp
Asp Glu Tyr Lys Glu 1025 1030 1035 Ser Val Phe Lys Ala Pro Tyr Gln
His Phe Val Asp Thr Leu Lys 1040 1045 1050 Ser Lys Glu Phe Glu Asp
Ser Ile Leu Phe Ser Tyr Gln Val Asp 1055 1060 1065 Ser Lys Phe Asn
Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr 1070 1075 1080 Arg Gln
Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val 1085 1090 1095
Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala 1100
1105 1110 Phe Met Lys Ile Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met
Tyr 1115 1120 1125 Arg His Asp Pro Gln Thr Phe Glu Lys Val Ile Glu
Pro Ile Leu 1130 1135 1140 Glu Asn Tyr Pro Asn Lys Gln Ile Asn Glu
Lys Gly Lys Glu Val 1145 1150 1155 Pro Cys Asn Pro Phe Leu Lys Tyr
Lys Glu Glu His Gly Tyr Ile 1160 1165 1170 Arg Lys Tyr Ser Lys Lys
Gly Asn Gly Pro Glu Ile Lys Ser Leu 1175 1180 1185 Lys Tyr Tyr Asp
Ser Lys Leu Gly Asn His Ile Asp Ile Thr Pro 1190 1195 1200 Lys Asp
Ser Asn Asn Lys Val Val Leu Gln Ser Val Ser Pro Trp 1205 1210 1215
Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly Lys Tyr Glu Ile 1220
1225 1230 Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys Gly Thr
Gly 1235 1240 1245 Thr Tyr Lys Ile Ser Gln Glu Lys Tyr Asn Asp Ile
Lys Lys Lys 1250 1255 1260 Glu Gly Val Asp Ser Asp Ser Glu Phe Lys
Phe Thr Leu Tyr Lys 1265 1270 1275 Asn Asp Leu Leu Leu Val Lys Asp
Thr Glu Thr Lys Glu Gln Gln 1280 1285 1290 Leu Phe Arg Phe Leu Ser
Arg Thr Met Pro Lys Gln Lys His Tyr 1295 1300 1305 Val Glu Leu Lys
Pro Tyr Asp Lys Gln Lys Phe Glu Gly Gly Glu 1310 1315 1320 Ala Leu
Ile Lys Val Leu Gly Asn Val Ala Asn Ser Gly Gln Cys 1325 1330 1335
Lys Lys Gly Leu Gly Lys Ser Asn Ile Ser Ile Tyr Lys Val Arg 1340
1345 1350 Thr Asp Val Leu Gly Asn Gln His Ile Ile Lys Asn Glu Gly
Asp 1355 1360 1365 Lys Pro Lys Leu Asp Phe 1370 884677DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
88tctttcttgc gctatgacac ttccagcaaa aggtagggcg ggctgcgaga cggcttcccg
60gcgctgcatg caacaccgat gatgcttcga ccccccgaag ctccttcggg gctgcatggg
120cgctccgatg ccgctccagg gcgagcgctg tttaaatagc caggcccccg
attgcaaaga 180cattatagcg agctaccaaa gccatattca aacacctaga
tcactaccac ttctacacag 240gccactcgag cttgtgatcg cactccgcta
agggggcgcc tcttcctctt cgtttcagtc 300acaacccgca aacatgtacc
catacgatgt tccagattac gcttcgccga agaaaaagcg 360caaggtcgaa
gcgtccgaca agaagtacag catcggcctg gacatcggca ccaactctgt
420gggctgggcc gtgatcaccg acgagtacaa ggtgcccagc aagaaattca
aggtgctggg 480caacaccgac cggcacagca tcaagaagaa cctgatcgga
gccctgctgt tcgacagcgg 540cgaaacagcc gaggccaccc ggctgaagag
aaccgccaga agaagataca ccagacggaa 600gaaccggatc tgctatctgc
aagagatctt cagcaacgag atggccaagg tggacgacag 660cttcttccac
agactggaag agtccttcct ggtggaagag gataagaagc acgagcggca
720ccccatcttc ggcaacatcg tggacgaggt ggcctaccac gagaagtacc
ccaccatcta 780ccacctgaga aagaaactgg tggacagcac cgacaaggcc
gacctgcggc tgatctatct 840ggccctggcc cacatgatca agttccgggg
ccacttcctg atcgagggcg acctgaaccc 900cgacaacagc gacgtggaca
agctgttcat ccagctggtg cagacctaca accagctgtt 960cgaggaaaac
cccatcaacg ccagcggcgt ggacgccaag gccatcctgt ctgccagact
1020gagcaagagc agacggctgg aaaatctgat cgcccagctg cccggcgaga
agaagaatgg 1080cctgttcggc aacctgattg ccctgagcct gggcctgacc
cccaacttca agagcaactt 1140cgacctggcc gaggatgcca aactgcagct
gagcaaggac acctacgacg acgacctgga 1200caacctgctg gcccagatcg
gcgaccagta cgccgacctg tttctggccg ccaagaacct 1260gtccgacgcc
atcctgctga gcgacatcct gagagtgaac accgagatca ccaaggcccc
1320cctgagcgcc tctatgatca agagatacga cgagcaccac caggacctga
ccctgctgaa 1380agctctcgtg cggcagcagc tgcctgagaa gtacaaagag
attttcttcg accagagcaa 1440gaacggctac gccggctaca ttgacggcgg
agccagccag gaagagttct acaagttcat 1500caagcccatc ctggaaaaga
tggacggcac cgaggaactg ctcgtgaagc tgaacagaga 1560ggacctgctg
cggaagcagc ggaccttcga caacggcagc atcccccacc agatccacct
1620gggagagctg cacgccattc tgcggcggca ggaagatttt tacccattcc
tgaaggacaa 1680ccgggaaaag atcgagaaga tcctgacctt ccgcatcccc
tactacgtgg gccctctggc 1740caggggaaac agcagattcg cctggatgac
cagaaagagc gaggaaacca tcaccccctg 1800gaacttcgag gaagtggtgg
acaagggcgc ttccgcccag agcttcatcg agcggatgac 1860caacttcgat
aagaacctgc ccaacgagaa ggtgctgccc aagcacagcc tgctgtacga
1920gtacttcacc gtgtataacg agctgaccaa agtgaaatac gtgaccgagg
gaatgagaaa 1980gcccgccttc ctgagcggcg agcagaaaaa ggccatcgtg
gacctgctgt tcaagaccaa 2040ccggaaagtg accgtgaagc agctgaaaga
ggactacttc aagaaaatcg agtgcttcga 2100ctccgtggaa atctccggcg
tggaagatcg gttcaacgcc tccctgggca cataccacga 2160tctgctgaaa
attatcaagg acaaggactt cctggacaat gaggaaaacg aggacattct
2220ggaagatatc gtgctgaccc tgacactgtt tgaggacaga gagatgatcg
aggaacggct 2280gaaaacctat gcccacctgt tcgacgacaa agtgatgaag
cagctgaagc ggcggagata 2340caccggctgg ggcaggctga gccggaagct
gatcaacggc atccgggaca agcagtccgg 2400caagacaatc ctggatttcc
tgaagtccga cggcttcgcc aacagaaact tcatgcagct 2460gatccacgac
gacagcctga cctttaaaga ggacatccag aaagcccagg tgtccggcca
2520gggcgatagc ctgcacgagc acattgccaa tctggccggc agccccgcca
ttaagaaggg 2580catcctgcag acagtgaagg tggtggacga gctcgtgaaa
gtgatgggcc ggcacaagcc 2640cgagaacatc gtgatcgaaa tggccagaga
gaaccagacc acccagaagg gacagaagaa 2700cagccgcgag agaatgaagc
ggatcgaaga gggcatcaaa gagctgggca gccagatcct 2760gaaagaacac
cccgtggaaa acacccagct gcagaacgag aagctgtacc tgtactacct
2820gcagaatggg cgggatatgt acgtggacca ggaactggac atcaaccggc
tgtccgacta 2880cgatgtggac catatcgtgc ctcagagctt tctgaaggac
gactccatcg acaacaaggt 2940gctgaccaga agcgacaaga accggggcaa
gagcgacaac gtgccctccg aagaggtcgt 3000gaagaagatg aagaactact
ggcggcagct gctgaacgcc aagctgatta cccagagaaa 3060gttcgacaat
ctgaccaagg ccgagagagg cggcctgagc gaactggata aggccggctt
3120catcaagaga cagctggtgg aaacccggca gatcacaaag cacgtggcac
agatcctgga 3180ctcccggatg aacactaagt acgacgagaa tgacaagctg
atccgggaag tgaaagtgat 3240caccctgaag tccaagctgg tgtccgattt
ccggaaggat ttccagtttt acaaagtgcg 3300cgagatcaac aactaccacc
acgcccacga cgcctacctg aacgccgtcg tgggaaccgc 3360cctgatcaaa
aagtacccta agctggaaag cgagttcgtg tacggcgact acaaggtgta
3420cgacgtgcgg aagatgatcg ccaagagcga gcaggaaatc ggcaaggcta
ccgccaagta 3480cttcttctac agcaacatca tgaacttttt caagaccgag
attaccctgg ccaacggcga 3540gatccggaag cggcctctga tcgagacaaa
cggcgaaacc ggggagatcg tgtgggataa 3600gggccgggat tttgccaccg
tgcggaaagt gctgagcatg ccccaagtga atatcgtgaa 3660aaagaccgag
gtgcagacag gcggcttcag caaagagtct atcctgccca agaggaacag
3720cgataagctg atcgccagaa agaaggactg ggaccctaag aagtacggcg
gcttcgacag 3780ccccaccgtg gcctattctg tgctggtggt ggccaaagtg
gaaaagggca agtccaagaa 3840actgaagagt gtgaaagagc tgctggggat
caccatcatg gaaagaagca gcttcgagaa 3900gaatcccatc gactttctgg
aagccaaggg ctacaaagaa gtgaaaaagg acctgatcat 3960caagctgcct
aagtactccc tgttcgagct ggaaaacggc cggaagagaa tgctggcctc
4020tgccggcgaa ctgcagaagg gaaacgaact ggccctgccc tccaaatatg
tgaacttcct 4080gtacctggcc agccactatg agaagctgaa gggctccccc
gaggataatg agcagaaaca 4140gctgtttgtg gaacagcaca agcactacct
ggacgagatc atcgagcaga tcagcgagtt 4200ctccaagaga gtgatcctgg
ccgacgctaa tctggacaaa gtgctgtccg cctacaacaa 4260gcaccgggat
aagcccatca gagagcaggc cgagaatatc atccacctgt ttaccctgac
4320caatctggga gcccctgccg ccttcaagta ctttgacacc accatcgacc
ggaagaggta 4380caccagcacc aaagaggtgc tggacgccac cctgatccac
cagagcatca ccggcctgta 4440cgagacacgg atcgacctgt ctcagctggg
aggcgacagc cccaagaaga agagaaaggt 4500ggaggccagc taaggatccg
gcaagactgg ccccgcttgg caacgcaaca gtgagcccct 4560ccctagtgtg
tttggggatg tgactatgta ttcgtgtgtt ggccaacggg tcaacccgaa
4620cagattgata cccgccttgg catttcctgt cagaatgtaa cgtcagttga tggtact
4677893150DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 89tctttcttgc gctatgacac ttccagcaaa
aggtagggcg ggctgcgaga cggcttcccg 60gcgctgcatg caacaccgat gatgcttcga
ccccccgaag ctccttcggg gctgcatggg 120cgctccgatg ccgctccagg
gcgagcgctg tttaaatagc caggcccccg attgcaaaga 180cattatagcg
agctaccaaa gccatattca aacacctaga tcactaccac ttctacacag
240gccactcgag cttgtgatcg cactccgcta agggggcgcc tcttcctctt
cgtttcagtc 300acaacccgca aacatgccta agaagaagag gaaggttaac
acgattaaca tcgctaagaa 360cgacttctct gacatcgaac tggctgctat
cccgttcaac actctggctg accattacgg 420tgagcgttta gctcgcgaac
agttggccct tgagcatgag tcttacgaga tgggtgaagc 480acgcttccgc
aagatgtttg agcgtcaact taaagctggt gaggttgcgg ataacgctgc
540cgccaagcct ctcatcacta ccctactccc taagatgatt gcacgcatca
acgactggtt 600tgaggaagtg aaagctaagc gcggcaagcg cccgacagcc
ttccagttcc tgcaagaaat 660caagccggaa gccgtagcgt acatcaccat
taagaccact ctggcttgcc taaccagtgc 720tgacaataca accgttcagg
ctgtagcaag cgcaatcggt cgggccattg aggacgaggc 780tcgcttcggt
cgtatccgtg accttgaagc taagcacttc aagaaaaacg ttgaggaaca
840actcaacaag cgcgtagggc acgtctacaa gaaagcattt atgcaagttg
tcgaggctga 900catgctctct aagggtctac tcggtggcga ggcgtggtct
tcgtggcata aggaagactc 960tattcatgta ggagtacgct gcatcgagat
gctcattgag tcaaccggaa tggttagctt 1020acaccgccaa aatgctggcg
tagtaggtca agactctgag actatcgaac tcgcacctga 1080atacgctgag
gctatcgcaa cccgtgcagg tgcgctggct ggcatctctc cgatgttcca
1140accttgcgta gttcctccta agccgtggac tggcattact ggtggtggct
attgggctaa 1200cggtcgtcgt cctctggcgc tggtgcgtac tcacagtaag
aaagcactga tgcgctacga 1260agacgtttac atgcctgagg tgtacaaagc
gattaacatt gcgcaaaaca ccgcatggaa 1320aatcaacaag aaagtcctag
cggtcgccaa cgtaatcacc aagtggaagc attgtccggt 1380cgaggacatc
cctgcgattg agcgtgaaga actcccgatg aaaccggaag acatcgacat
1440gaatcctgag gctctcaccg cgtggaaacg tgctgccgct gctgtgtacc
gcaaggacaa 1500ggctcgcaag tctcgccgta tcagccttga gttcatgctt
gagcaagcca ataagtttgc
1560taaccataag gccatctggt tcccttacaa catggactgg cgcggtcgtg
tttacgctgt 1620gtcaatgttc aacccgcaag gtaacgatat gaccaaagga
ctgcttacgc tggcgaaagg 1680taaaccaatc ggtaaggaag gttactactg
gctgaaaatc cacggtgcaa actgtgcggg 1740tgtcgacaag gttccgttcc
ctgagcgcat caagttcatt gaggaaaacc acgagaacat 1800catggcttgc
gctaagtctc cactggagaa cacttggtgg gctgagcaag attctccgtt
1860ctgcttcctt gcgttctgct ttgagtacgc tggggtacag caccacggcc
tgagctataa 1920ctgctccctt ccgctggcgt ttgacgggtc ttgctctggc
atccagcact tctccgcgat 1980gctccgagat gaggtaggtg gtcgcgcggt
taacttgctt cctagtgaaa ccgttcagga 2040catctacggg attgttgcta
agaaagtcaa cgagattcta caagcagacg caatcaatgg 2100gaccgataac
gaagtagtta ccgtgaccga tgagaacact ggtgaaatct ctgagaaagt
2160caagctgggc actaaggcac tggctggtca atggctggct tacggtgtta
ctcgcagtgt 2220gactaagcgt tcagtcatga cgctggctta cgggtccaaa
gagttcggct tccgtcaaca 2280agtgctggaa gataccattc agccagctat
tgattccggc aagggtctga tgttcactca 2340gccgaatcag gctgctggat
acatggctaa gctgatttgg gaatctgtga gcgtgacggt 2400ggtagctgcg
gttgaagcaa tgaactggct taagtctgct gctaagctgc tggctgctga
2460ggtcaaagat aagaagactg gagagattct tcgcaagcgt tgcgctgtgc
attgggtaac 2520tcctgatggt ttccctgtgt ggcaggaata caagaagcct
attcagacgc gcttgaacct 2580gatgttcctc ggtcagttcc gcttacagcc
taccattaac accaacaaag atagcgagat 2640tgatgcacac aaacaggagt
ctggtatcgc tcctaacttt gtacacagcc aagacggtag 2700ccaccttcgt
aagactgtag tgtgggcaca cgagaagtac ggaatcgaat cttttgcact
2760gattcacgac tccttcggta cgattccggc tgacgctgcg aacctgttca
aagcagtgcg 2820cgaaactatg gttgacacat atgagtcttg tgatgtactg
gctgatttct acgaccagtt 2880cgctgaccag ttgcacgagt ctcaattgga
caaaatgcca gcacttccgg ctaaaggtaa 2940cttgaacctc cgtgacatct
tagagtcgga cttcgcgttc gcgtaaggat ccggcaagac 3000tggccccgct
tggcaacgca acagtgagcc cctccctagt gtgtttgggg atgtgactat
3060gtattcgtgt gttggccaac gggtcaaccc gaacagattg atacccgcct
tggcatttcc 3120tgtcagaatg taacgtcagt tgatggtact
315090125DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 90gaaattaata cgactcacta tannnnnnnn
nnnnnnnnnn nngttttaga gctagaaata 60gcaagttaaa ataaggctag tccgttatca
acttgaaaaa gtggcaccga gtcggtgctt 120ttttt 125918452DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
91tgcggtattt cacaccgcat caggtggcac ttttcgggga aatgtgcgcg gaacccctat
60ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagattat caaaaaggat
120cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa
gtatatatga 180gtaaacttgg tctgacagtt accaatgctt aatcagtgag
gcacctatct cagcgatctg 240tctatttcgt tcatccatag ttgcctgact
ccccgtcgtg tagataacta cgatacggga 300gggcttacca tctggcccca
gtgctgcaat gataccgcga gacccacgct caccggctcc 360agatttatca
gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac
420tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa
gtagttcgcc 480agttaatagt ttgcgcaacg ttgttgccat tgctacaggc
atcgtggtgt cacgctcgtc 540gtttggtatg gcttcattca gctccggttc
ccaacgatca aggcgagtta catgatcccc 600catgttgtgc aaaaaagcgg
ttagctcctt cggtcctccg atcgttgtca gaagtaagtt 660ggccgcagtg
ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc
720atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct
gagaatagtg 780tatgcggcga ccgagttgct cttgcccggc gtcaatacgg
gataataccg cgccacatag 840cagaacttta aaagtgctca tcattggaaa
acgttcttcg gggcgaaaac tctcaaggat 900cttaccgctg ttgagatcca
gttcgatgta acccactcgt gcacccaact gatcttcagc 960atcttttact
ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa
1020aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt
ttcaatatta 1080ttgaagcatt tatcagggtt attgtctcat gaccaaaatc
ccttaacgtg agttttcgtt 1140ccactgagcg tcagaccccg tagaaaagat
caaaggatct tcttgagatc ctttttttct 1200gcgcgtaatc tgctgcttgc
aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc 1260ggatcaagag
ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc
1320aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact
ctgtagcacc 1380gcctacatac ctcgctctgc taatcctgtt accagtggct
gttgccagtg gcgataagtc 1440gtgtcttacc gggttggact caagacgata
gttaccggat aaggcgcagc ggtcgggctg 1500aacggggggt tcgtgcacac
agcccagctt ggagcgaacg acctacaccg aactgagata 1560cctacagcgt
gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta
1620tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag
ggggaaacgc 1680ctggtatctt tatagtcctg tcgggtttcg ccacctctga
cttgagcgtc gatttttgtg 1740atgctcgtca ggggggcgga gcctatggaa
aaacgccagc aacgcggcct ttttacggtt 1800cctggccttt tgctggcctt
ttgctcacat gttctttcct gcgttatccc ctgattctgt 1860ggataaccgt
attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga
1920gcgcagcgag tcagtgagcg aggaagcggt cgctgaggct tgacatgatt
ggtgcgtatg 1980tttgtatgaa gctacaggac tgatttggcg ggctatgagg
gcgggggaag ctctggaagg 2040gccgcgatgg ggcgcgcggc gtccagaagg
cgccatacgg cccgctggcg gcacccatcc 2100ggtataaaag cccgcgaccc
cgaacggtga cctccacttt cagcgacaaa cgagcactta 2160tacatacgcg
actattctgc cgctatacat aaccactcag ctagcttaag atcccatcaa
2220gcttgcatgc cgggcgcgcc agaaggagcg cagccaaacc aggatgatgt
ttgatggggt 2280atttgagcac ttgcaaccct tatccggaag ccccctggcc
cacaaaggct aggcgccaat 2340gcaagcagtt cgcatgcagc ccctggagcg
gtgccctcct gataaaccgg ccagggggcc 2400tatgttcttt acttttttac
aagagaagtc actcaacatc ttaaaatggc caggtgagtc 2460gacgagcaag
cccggcggat caggcagcgt gcttgcagat ttgacttgca acgcccgcat
2520tgtgtcgacg aaggcttttg gctcctctgt cgctgtctca agcagcatct
aaccctgcgt 2580cgccgtttcc atttgcagga gattcgaggt accatgtacc
catacgatgt tccagattac 2640gcttcgccga agaaaaagcg caaggtcgaa
gcgtccgaca agaagtacag catcggcctg 2700gacatcggca ccaactctgt
gggctgggcc gtgatcaccg acgagtacaa ggtgcccagc 2760aagaaattca
aggtgctggg caacaccgac cggcacagca tcaagaagaa cctgatcgga
2820gccctgctgt tcgacagcgg cgaaacagcc gaggccaccc ggctgaagag
aaccgccaga 2880agaagataca ccagacggaa gaaccggatc tgctatctgc
aagagatctt cagcaacgag 2940atggccaagg tggacgacag cttcttccac
agactggaag agtccttcct ggtggaagag 3000gataagaagc acgagcggca
ccccatcttc ggcaacatcg tggacgaggt ggcctaccac 3060gagaagtacc
ccaccatcta ccacctgaga aagaaactgg tggacagcac cgacaaggcc
3120gacctgcggc tgatctatct ggccctggcc cacatgatca agttccgggg
ccacttcctg 3180atcgagggcg acctgaaccc cgacaacagc gacgtggaca
agctgttcat ccagctggtg 3240cagacctaca accagctgtt cgaggaaaac
cccatcaacg ccagcggcgt ggacgccaag 3300gccatcctgt ctgccagact
gagcaagagc agacggctgg aaaatctgat cgcccagctg 3360cccggcgaga
agaagaatgg cctgttcggc aacctgattg ccctgagcct gggcctgacc
3420cccaacttca agagcaactt cgacctggcc gaggatgcca aactgcagct
gagcaaggac 3480acctacgacg acgacctgga caacctgctg gcccagatcg
gcgaccagta cgccgacctg 3540tttctggccg ccaagaacct gtccgacgcc
atcctgctga gcgacatcct gagagtgaac 3600accgagatca ccaaggcccc
cctgagcgcc tctatgatca agagatacga cgagcaccac 3660caggacctga
ccctgctgaa agctctcgtg cggcagcagc tgcctgagaa gtacaaagag
3720attttcttcg accagagcaa gaacggctac gccggctaca ttgacggcgg
agccagccag 3780gaagagttct acaagttcat caagcccatc ctggaaaaga
tggacggcac cgaggaactg 3840ctcgtgaagc tgaacagaga ggacctgctg
cggaagcagc ggaccttcga caacggcagc 3900atcccccacc agatccacct
gggagagctg cacgccattc tgcggcggca ggaagatttt 3960tacccattcc
tgaaggacaa ccgggaaaag atcgagaaga tcctgacctt ccgcatcccc
4020tactacgtgg gccctctggc caggggaaac agcagattcg cctggatgac
cagaaagagc 4080gaggaaacca tcaccccctg gaacttcgag gaagtggtgg
acaagggcgc ttccgcccag 4140agcttcatcg agcggatgac caacttcgat
aagaacctgc ccaacgagaa ggtgctgccc 4200aagcacagcc tgctgtacga
gtacttcacc gtgtataacg agctgaccaa agtgaaatac 4260gtgaccgagg
gaatgagaaa gcccgccttc ctgagcggcg agcagaaaaa ggccatcgtg
4320gacctgctgt tcaagaccaa ccggaaagtg accgtgaagc agctgaaaga
ggactacttc 4380aagaaaatcg agtgcttcga ctccgtggaa atctccggcg
tggaagatcg gttcaacgcc 4440tccctgggca cataccacga tctgctgaaa
attatcaagg acaaggactt cctggacaat 4500gaggaaaacg aggacattct
ggaagatatc gtgctgaccc tgacactgtt tgaggacaga 4560gagatgatcg
aggaacggct gaaaacctat gcccacctgt tcgacgacaa agtgatgaag
4620cagctgaagc ggcggagata caccggctgg ggcaggctga gccggaagct
gatcaacggc 4680atccgggaca agcagtccgg caagacaatc ctggatttcc
tgaagtccga cggcttcgcc 4740aacagaaact tcatgcagct gatccacgac
gacagcctga cctttaaaga ggacatccag 4800aaagcccagg tgtccggcca
gggcgatagc ctgcacgagc acattgccaa tctggccggc 4860agccccgcca
ttaagaaggg catcctgcag acagtgaagg tggtggacga gctcgtgaaa
4920gtgatgggcc ggcacaagcc cgagaacatc gtgatcgaaa tggccagaga
gaaccagacc 4980acccagaagg gacagaagaa cagccgcgag agaatgaagc
ggatcgaaga gggcatcaaa 5040gagctgggca gccagatcct gaaagaacac
cccgtggaaa acacccagct gcagaacgag 5100aagctgtacc tgtactacct
gcagaatggg cgggatatgt acgtggacca ggaactggac 5160atcaaccggc
tgtccgacta cgatgtggac catatcgtgc ctcagagctt tctgaaggac
5220gactccatcg acaacaaggt gctgaccaga agcgacaaga accggggcaa
gagcgacaac 5280gtgccctccg aagaggtcgt gaagaagatg aagaactact
ggcggcagct gctgaacgcc 5340aagctgatta cccagagaaa gttcgacaat
ctgaccaagg ccgagagagg cggcctgagc 5400gaactggata aggccggctt
catcaagaga cagctggtgg aaacccggca gatcacaaag 5460cacgtggcac
agatcctgga ctcccggatg aacactaagt acgacgagaa tgacaagctg
5520atccgggaag tgaaagtgat caccctgaag tccaagctgg tgtccgattt
ccggaaggat 5580ttccagtttt acaaagtgcg cgagatcaac aactaccacc
acgcccacga cgcctacctg 5640aacgccgtcg tgggaaccgc cctgatcaaa
aagtacccta agctggaaag cgagttcgtg 5700tacggcgact acaaggtgta
cgacgtgcgg aagatgatcg ccaagagcga gcaggaaatc 5760ggcaaggcta
ccgccaagta cttcttctac agcaacatca tgaacttttt caagaccgag
5820attaccctgg ccaacggcga gatccggaag cggcctctga tcgagacaaa
cggcgaaacc 5880ggggagatcg tgtgggataa gggccgggat tttgccaccg
tgcggaaagt gctgagcatg 5940ccccaagtga atatcgtgaa aaagaccgag
gtgcagacag gcggcttcag caaagagtct 6000atcctgccca agaggaacag
cgataagctg atcgccagaa agaaggactg ggaccctaag 6060aagtacggcg
gcttcgacag ccccaccgtg gcctattctg tgctggtggt ggccaaagtg
6120gaaaagggca agtccaagaa actgaagagt gtgaaagagc tgctggggat
caccatcatg 6180gaaagaagca gcttcgagaa gaatcccatc gactttctgg
aagccaaggg ctacaaagaa 6240gtgaaaaagg acctgatcat caagctgcct
aagtactccc tgttcgagct ggaaaacggc 6300cggaagagaa tgctggcctc
tgccggcgaa ctgcagaagg gaaacgaact ggccctgccc 6360tccaaatatg
tgaacttcct gtacctggcc agccactatg agaagctgaa gggctccccc
6420gaggataatg agcagaaaca gctgtttgtg gaacagcaca agcactacct
ggacgagatc 6480atcgagcaga tcagcgagtt ctccaagaga gtgatcctgg
ccgacgctaa tctggacaaa 6540gtgctgtccg cctacaacaa gcaccgggat
aagcccatca gagagcaggc cgagaatatc 6600atccacctgt ttaccctgac
caatctggga gcccctgccg ccttcaagta ctttgacacc 6660accatcgacc
ggaagaggta caccagcacc aaagaggtgc tggacgccac cctgatccac
6720cagagcatca ccggcctgta cgagacacgg atcgacctgt ctcagctggg
aggcgacagc 6780cccaagaaga agagaaaggt ggaggccagc taacatatga
ttcgaatgtc tttcttgcgc 6840tatgacactt ccagcaaaag gtagggcggg
ctgcgagacg gcttcccggc gctgcatgca 6900acaccgatga tgcttcgacc
ccccgaagct ccttcggggc tgcatgggcg ctccgatgcc 6960gctccagggc
gagcgctgtt taaatagcca ggcccccgat tgcaaagaca ttatagcgag
7020ctaccaaagc catattcaaa cacctagatc actaccactt ctacacaggc
cactcgagct 7080tgtgatcgca ctccgctaag ggggcgcctc ttcctcttcg
tttcagtcac aacccgcaaa 7140catgacacaa gaatccctgt tacttctcga
ccgtattgat tcggatgatt cctacgcgag 7200cctgcggaac gaccaggaat
tctgggaggt gagtcgacga gcaagcccgg cggatcaggc 7260agcgtgcttg
cagatttgac ttgcaacgcc cgcattgtgt cgacgaaggc ttttggctcc
7320tctgtcgctg tctcaagcag catctaaccc tgcgtcgccg tttccatttg
cagccgctgg 7380cccgccgagc cctggaggag ctcgggctgc cggtgccgcc
ggtgctgcgg gtgcccggcg 7440agagcaccaa ccccgtactg gtcggcgagc
ccggcccggt gatcaagctg ttcggcgagc 7500actggtgcgg tccggagagc
ctcgcgtcgg agtcggaggc gtacgcggtc ctggcggacg 7560ccccggtgcc
ggtgccccgc ctcctcggcc gcggcgagct gcggcccggc accggagcct
7620ggccgtggcc ctacctggtg atgagccgga tgaccggcac cacctggcgg
tccgcgatgg 7680acggcacgac cgaccggaac gcgctgctcg ccctggcccg
cgaactcggc cgggtgctcg 7740gccggctgca cagggtgccg ctgaccggga
acaccgtgct caccccccat tccgaggtct 7800tcccggaact gctgcgggaa
cgccgcgcgg cgaccgtcga ggaccaccgc gggtggggct 7860acctctcgcc
ccggctgctg gaccgcctgg aggactggct gccggacgtg gacacgctgc
7920tggccggccg cgaaccccgg ttcgtccacg gcgacctgca cgggaccaac
atcttcgtgg 7980acctggccgc gaccgaggtc accgggatcg tcgacttcac
cgacgtctat gcgggagact 8040cccgctacag cctggtgcaa ctgcatctca
acgccttccg gggcgaccgc gagatcctgg 8100ccgcgctgct cgacggggcg
cagtggaagc ggaccgagga cttcgcccgc gaactgctcg 8160ccttcacctt
cctgcacgac ttcgaggtgt tcgaggagac cccgctggat ctctccggct
8220tcaccgatcc ggaggaactg gcgcagttcc tctgggggcc gccggacacc
gcccccggcg 8280cctgataagg atccggcaag actggccccg cttggcaacg
caacagtgag cccctcccta 8340gtgtgtttgg ggatgtgact atgtattcgt
gtgttggcca acgggtcaac ccgaacagat 8400tgatacccgc cttggcattt
cctgtcagaa tgtaacgtca gttgatggta ct 845292102DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
92gttttagagc tatgctgttt tgaatggtcc caaaacggaa gggcctgagt ccgagcagaa
60gaagaagttt tagagctatg ctgttttgaa tggtcccaaa ac 10293100DNAHomo
sapiens 93cggaggacaa agtacaaacg gcagaagctg gaggaggaag ggcctgagtc
cgagcagaag 60aagaagggct cccatcacat caaccggtgg cgcattgcca
1009450DNAHomo sapiens 94agctggagga ggaagggcct gagtccgagc
agaagaagaa gggctcccac 509530RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 95gaguccgagc
agaagaagaa guuuuagagc 309649DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 96agctggagga
ggaagggcct gagtccgagc agaagagaag ggctcccat 499753DNAHomo sapiens
97ctggaggagg aagggcctga gtccgagcag aagaagaagg gctcccatca cat
539852DNAHomo sapiens 98ctggaggagg aagggcctga gtccgagcag aagagaaggg
ctcccatcac at 529954DNAHomo sapiens 99ctggaggagg aagggcctga
gtccgagcag aagaaagaag ggctcccatc acat 5410050DNAHomo sapiens
100ctggaggagg aagggcctga gtccgagcag aagaagggct cccatcacat
5010147DNAHomo sapiens 101ctggaggagg aagggcctga gcccgagcag
aagggctccc atcacat 47102155RNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotide 102guuucagugc
uauaggaaac uauaggaaau caccuucggg ugagcugaaa uccccuaaag 60cuaagauuga
auccggccac uaucuauuag uagauauccg gauauucuga uauaaaaccu
120cauucuuuga uuagaccaaa ggaugagguu uuuuu 155103107RNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
103guuugagagu uggaaacaac gaguucaaau aagaauucau caaaaucguc
ccuuuuggga 60ccgcucauug uggagcauca aggcuuaaca ugguuaagcc uuuuuuu
10710499RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 104guuugagagu aggaaacuac acgguucaaa
uaaagaauuu uucuaaucgc ccaaugggcc 60cauauugaua uggaugaaac ucgcuuagcg
aguuuuuuu 9910591RNAArtificial SequenceDescription of Artificial
Sequence Synthetic oligonucleotide 105guuuuagcac uagaaauagu
uaaguuaaaa caagcuuaaa gcgucaaugu aauauuuuau 60uaacacccua cugugucagu
gggguuuuuu u 9110694RNAArtificial SequenceDescription of Artificial
Sequence Synthetic oligonucleotide 106guuuuagaug gugaaaacca
gauuuaaaau caagcaaugc aucuuuugau gcaaaguuuc 60aauauuuguc ccacguuauc
gagggacuuu uuuu 9410778RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 107auuuuaguac
cuggaaacag aucuacuaaa acaaggcuuu augccgaaau caagagcacc 60gacgggugcu
cuuuuuuu 7810884RNAArtificial SequenceDescription of Artificial
Sequence Synthetic oligonucleotide 108guuuuuguac ucgaaagagc
cuacaaagau aaggcuuuau gccgaauuca agcaccccau 60guuuugacau gaggugcuuu
uuuu 8410985RNAArtificial SequenceDescription of Artificial
Sequence Synthetic oligonucleotide 109guuuuuguac cuuagaaaua
agaucuacaa aaauaaggau uuauuccgaa uuuaccaccu 60auuuuaauua auaggugguu
uuuuu 85110100RNAArtificial SequenceDescription of Artificial
Sequence Synthetic polynucleotide 110guugugauuu gcuuucauuu
gaaaaauuga agcaaaucac aauaaggauu auuccguugu 60gaaaacaauu aaagcggucu
ugcaaaaggu cgcuuuuuuu 100111102RNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotide 111guugugauuc
gcuuucaaug aaaauugaag cgaaucacaa uaaggauuau uccguuguga 60aaacauuuac
uacggggcau cgaaagacug ccucguuuuu uu 10211290RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 112guugugguuu gauuagaaau aaucuuauca caauaaggcu
auaugccgua gacgaaaguc 60uuuagucccg cuucgguggg acuuuuuuuu
9011378RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 113guuggggaug accgcgaaag cgauuaucuc
uaauaagacu uaagucgcaa aaugcucccu 60auuuugggag cuuuuuuu
7811485RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 114guugcggcug gagaaaucca gccguuaaca
uguucccuuc ggggagcacg aaaugcgggg 60cgggccacgg uccgccccuu uuuuu
85115126RNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 115gccgugguuu ccgaaaggaa accacgguaa
cagaauuacc guaagguuuu uucugugaag 60gaucaucccu cgcuugggca accaggcggg
ggaaauuccu cguucgggcc aaucagcccu 120uuuuuu 12611682RNAArtificial
SequenceDescription of Artificial Sequence Synthetic
oligonucleotide 116guuguaauuc ccugaaaagg uuauuacaau aagguaagaa
accuaaaagc ucuaauccca 60uucuucggaa ugggauuuuu uu
8211783RNAArtificial SequenceDescription of Artificial Sequence
Synthetic oligonucleotide 117guuuuaguac ucuggaaaca gaaucuacua
aaacaaggca aaaugccgug uuuaucucgu 60caacuuguug gcgagauuuu uuu
8311894RNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 118guuuuagcac
uguacaagaa auugucgugc uaaaauaagg cgcuguuaau gcagcugccg 60cauccgccag
agcauuuaug cucuggcuuu uuuu 941194350DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
119accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtccatgac tcagagcgag cgacgatttt cttgcagcat
tggcattgac 120atgggggcta agtacactgg ggtgttctac gcactgttcg
accgggagga actgcccaca 180aacctgaaca gcaaggccat gaccctggtc
atgcctgaga cagggccaag atacgtgcag 240gcacagagaa ctgccgtcag
acacaggctg cgcggacaga agagatatac cctggctagg 300aaactggcat
ttctggtggt cgacgatatg atcaagaaac aggaaaagag gctgactgat
360gaggaatgga aacgaggacg ggaggccctg tccggcctgc tgaagcggag
agggtactct 420cggcccaacg ctgacggcga agatctgacc cctctggaga
atgtgagagc agacgtgttc 480gccgctcatc ctgccttcag cacatatttt
tccgaagtgc gctctctggc tgagcagtgg 540gaggagttca ccgcaaacat
cagcaatgtc gagaagtttc tgggcgaccc aaacatcccc 600gccgataaag
agttcattga atttgccgtg gctgaagggc tgattgacaa gaccgagaag
660aaagcctacc agtcagctct gagcaccctg agggcaaacg ccaatgtgct
gacaggactg 720cggcagatgg gccacaagcc tagatcagaa tattttaaag
caatcgaggc cgacctgaag 780aaagatagcc gcctggccaa gattaacgaa
gcattcggag gagcagagcg cctggctcga 840ctgctgggaa acctgtccaa
tctgcagctg cgggcagaaa gatggtactt caatgccccc 900gacatcatga
aggatagggg ctgggagcct gatcgcttca agaaaacact ggtgcgggct
960tttaagttct ttcacccagc aaaggaccag aacaaacagc atctggaact
gatcaaacag 1020attgagaaca gcgaagatat cattgagact ctgtgcaccc
tggacccaaa cagaaccatc 1080cccccttacg aggatcagaa caataggcgc
ccacccctgg accagactct gctgctgagt 1140cccgaaaagc tgacccggca
gtatggcgag atctggaaaa catggagcgc cagactgacc 1200tccgctgaac
ccacactggc acctgcagcc gagattctgg aaagatctac cgacaggaag
1260agtcgcgtgg cagtcaacgg acacgagcca ctgcctacac tggcttacca
gctgagttat 1320gcactgcaga gagccttcga caggtcaaaa gccctggatc
catatgctct gagggcactg 1380gctgcaggct caaaaagcaa taagctgaca
tccgcccgca ctgctctgga gaactgcatc 1440ggaggccaga atgtgaaaac
cttcctggac tgtgcccgac ggtactatcg ggaagcagac 1500gatgccaaag
tcgggctgtg gttcgacaac gccgatggac tgctggagag atctgacctg
1560catcctccaa tgaagaaaaa gatcctgccc ctgctggtgg ccaatattct
gcagacagat 1620gaaaccacag gccagaagtt tctggacgag atctggcgaa
aacagattaa ggggcgggaa 1680actgtggcta gccgatgtgc acggatcgag
acagtgcgga aatccttcgg gggaggcttt 1740aacattgcct acaataccgc
tcagtatagg gaggtgaaca agctgccccg caatgcccag 1800gataaagaac
tgctgacaat cagagatagg gtggctgaga ctgcagactt cattgccgct
1860aacctggggc tgtctgacga gcagaaaaga aagttcgcca atccttttag
tctggctcag 1920ttctacaccc tgatcgagac agaagtgtcc ggattttctg
caactaccct ggccgtccac 1980ctggagaacg cctggaggat gacaatcaag
gatgctgtga ttaatgggga aactgtcaga 2040gcagcacagt gcagcaggct
gcctgcagag acagctcgcc cattcgatgg actggtgaga 2100aggctggtcg
acagacaggc ttgggagatc gcaaagaggg tgtcaactga cattcagagc
2160aaagtcgatt tctccaacgg catcgtggac gtcagcattt ttgtggagga
aaataagttc 2220gagttttccg catctgtggc cgatctgaaa aagaacaaac
gggtcaaaga caagatgctg 2280tccgaggccg aaaagctgga aaccagatgg
ctgatcaaaa atgagcggat caagaaggcc 2340agccggggaa cttgtcccta
caccggcgat aggctggctg aggggggaga aatcgaccac 2400attctgcccc
gaagcctgat caaggatgcc cggggaattg tgtttaacgc tgagcctaat
2460ctgatctatg caagctcccg cggcaaccag ctgaaaaaga atcagcgata
cagtctgtca 2520gatctgaagg ccaactatcg gaatgagatc ttcaaaacta
gcaacatcgc tgcaattacc 2580gccgagattg aggacgtggt cactaagctg
cagcagaccc atagactgaa attctttgat 2640ctgctgaatg agcacgaaca
ggactgcgtg cggcacgccc tgttcctgga cgatggcagc 2700gaagctcgcg
acgcagtgct ggagctgctg gcaacacagc gccgaactcg cgtcaacggg
2760acacagatct ggatgattaa gaacctggcc aacaagatcc gagaggaact
gcagaattgg 2820tgtaagacaa ctaacaatag actgcacttt caggccgctg
caactaacgt gtccgatgca 2880aagaatctga ggctgaaact ggcccagaac
cagcccgact tcgagaagcc agatatccag 2940cccattgcca gccattccat
cgacgccctg tgctctttcg ctgtggggag tgctgacgca 3000gaacgcgatc
agaatggatt tgactacctg gatggcaaga ccgtgctggg actgtatcca
3060cagagctgtg aggtcattca cctgcaggcc aagccccagg aggaaaaaag
tcatttcgat 3120tcagtggcta tctttaagga aggcatctac gcagagcagt
tcctgcctat ctttaccctg 3180aacgaaaaga tctggattgg atatgagaca
ctgaatgcca aaggcgaaag atgcggggct 3240attgaggtga gtggcaaaca
gccaaaggag ctgctggaaa tgctggcccc cttctttaac 3300aagcctgtgg
gcgacctgtc agcccacgct acttaccgga tcctgaaaaa gcctgcatat
3360gagtttctgg caaaggcagc tctgcagcca ctgagcgcag aggaaaaaag
actggcagcc 3420ctgctggatg ctctgcgcta ctgtaccagt cgaaagtcac
tgatgagcct gttcatggct 3480gcaaacggga aatccctgaa aaagcgggag
gacgtgctga aacccaagct gttccagctg 3540aaggtcgagc tgaaaggcga
aaagagcttc aagctgaacg ggagcctgac cctgcctgtg 3600aagcaggact
ggctgagaat ctgcgatagc ccagaactgg cagacgcctt tggcaaaccc
3660tgttccgccg atgagctgac atctaagctg gctcgcattt ggaaacgacc
tgtgatgcgg 3720gatctggctc atgcaccagt ccggagagag ttcagcctgc
ccgcaatcga caacccaagt 3780ggagggttca ggattaggcg caccaacctg
tttggcaatg agctgtacca ggtgcacgcc 3840atcaacgcta aaaagtatcg
cggcttcgcc tccgctgggt ctaatgtcga ctggtccaag 3900gggatcctgt
ttaacgagct gcagcatgaa aatctgaccg agtgcggagg caggttcatt
3960acaagcgccg atgtgactcc tatgtccgaa tggcgcaagg tggtcgcaga
ggacaacctg 4020tctatctgga ttgctccagg gacagaagga cgacggtacg
tgagggtcga gacaacattc 4080atccaggcca gtcactggtt tgaacagtca
gtggagaatt gggccattac tagtcctctg 4140tcactgccag cttccttcaa
ggtggacaaa ccagctgagt ttcagaaggc agtcggaacc 4200gagctgtcag
aactgctggg ccagcccagg agcgaaatct tcattgagaa cgtgggcaat
4260gccaagcata tccgcttttg gtacattgtg gtgagcagca acaaaaagat
gaacgagtct 4320tacaacaatg tgtctaagag ttaagaattc
43501204269DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 120accggtgcca ccatgtaccc atacgatgtt
ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag cgtccatgaa aaaagaaatc
aaagactact tcctggggct ggatgtgggg 120actgggagcg tggggtgggc
tgtgaccgat actgactaca aactgctgaa ggctaaccga 180aaagacctgt
ggggcatgag atgcttcgag acagccgaaa ctgctgaggt gcggagactg
240cacaggggag ccaggcgccg aatcgagcgg agaaagaaac gcattaagct
gctgcaggag 300ctgttctctc aggaaatcgc caaaaccgat gagggcttct
ttcagagaat gaaggaaagc 360cccttttacg ctgaggacaa aacaatcctg
caggaaaaca ctctgttcaa tgacaaggat 420tttgctgata agacttacca
caaagcatat cctaccatta atcatctgat caaggcttgg 480attgagaaca
aggtgaaacc agacccccga ctgctgtacc tggcatgtca caacatcatt
540aagaaaaggg gacatttcct gtttgaaggc gacttcgatt cagagaatca
gtttgatacc 600agcatccagg cactgttcga gtatctgcgc gaggacatgg
aggtggacat cgatgccgac 660agccagaagg tcaaagagat tctgaaggat
agctccctga agaactctga aaaacagagt 720cggctgaata agatcctggg
gctgaagcct tccgacaaac agaagaaagc catcacaaac 780ctgatttctg
gaaacaagat caatttcgcc gatctgtacg acaatccaga tctgaaggac
840gctgagaaaa actcaatcag cttctccaag gacgattttg atgcactgag
tgacgatctg 900gcctcaattc tgggcgacag ctttgaactg ctgctgaagg
ccaaagctgt ctataactgc 960tctgtgctga gtaaggtcat cggggacgag
cagtacctga gcttcgccaa ggtgaaaatc 1020tacgaaaagc acaaaaccga
tctgacaaag ctgaaaaacg tgatcaagaa acatttcccc 1080aaggactaca
agaaggtctt tggatacaac aagaacgaga aaaacaacaa caattactcc
1140ggctatgtgg gagtctgtaa gaccaagagt aagaaactga tcattaacaa
ctcagtcaac 1200caggaagatt tctacaagtt tctgaaaact atcctgtcag
ccaagagcga gatcaaggaa 1260gtgaatgaca tcctgaccga gattgaaact
ggcacctttc tgccaaagca gatctctaaa 1320agtaacgcag agattcccta
tcagctgagg aaaatggagc tggaaaagat cctgtccaat 1380gccgaaaagc
acttctcttt tctgaagcag aaagacgaaa aaggactgtc acatagcgag
1440aagatcatta tgctgctgac cttcaagatc ccttactata ttggcccaat
caacgataat 1500cacaagaaat tctttcccga cagatgctgg gtggtcaaga
aagagaaatc cccttctggc 1560aagaccacac catggaactt ctttgatcat
atcgacaagg aaaaaacagc agaggccttc 1620attacttcta ggaccaattt
ttgcacttac ctggtgggag agagcgtcct gcctaagtct 1680agtctgctgt
actccgaata taccgtgctg aacgagatca acaatctgca gatcattatc
1740gatggcaaga atatttgtga catcaagctg aaacagaaga tctacgagga
cctgttcaag 1800aagtacaaga aaattaccca gaagcagatc agcaccttca
tcaagcacga aggcatctgc 1860aacaaaaccg atgaagtgat catcctgggg
attgacaagg aatgtacatc aagcctgaaa 1920agctacatcg agctgaaaaa
cattttcggc aagcaggtgg atgagatctc cactaagaat 1980atgctggagg
aaattatcag atgggctacc atctacgacg agggggaagg aaagaccatc
2040ctgaaaacaa agatcaaggc agaatacgga aagtattgct ccgacgagca
gattaagaaa 2100atcctgaacc tgaagttctc cggctggggg cgactgtctc
ggaaatttct ggagacagtg 2160actagtgaaa tgcccggctt ctcagaacct
gtcaatatta tcaccgccat gagggagaca 2220cagaacaatc tgatggagct
gctgtcctct gagttcacct tcaccgagaa cattaagaaa 2280atcaattctg
gattcgaaga tgccgagaag cagtttagtt acgacggcct ggtgaaacca
2340ctgtttctga gtccctcagt caagaaaatg ctgtggcaga ccctgaagct
ggtgaaagag 2400attagccata tcacacaggc cccccctaag aaaattttca
tcgaaatggc aaagggggcc 2460gagctggaac ctgctcggac taagaccaga
ctgaaaatcc tgcaggatct gtataacaat 2520tgtaagaacg atgctgacgc
cttcagctca gagatcaaag acctgagcgg aaagattgag 2580aacgaagata
atctgaggct gcgctccgac aagctgtacc tgtactatac tcagctgggg
2640aaatgcatgt attgtggaaa gccaattgag atcggccacg tgttcgatac
ctcaaactac 2700gatattgacc atatctatcc ccagagcaag atcaaagacg
atagcatttc caatcgggtg 2760ctggtctgca gctcctgtaa caagaacaag
gaggacaagt acccactgaa atcagagatc 2820cagagcaagc agcgcggctt
ctggaacttt ctgcagcgaa acaatttcat ttctctggag 2880aagctgaata
gactgacaag ggccactcca atcagtgacg atgagacagc caagtttatt
2940gctaggcagc tggtggaaac tcgccaggct accaaggtgg ccgctaaagt
cctggaaaag 3000atgttccccg agacaaaaat cgtgtacagc aaggccgaga
ctgtctccat gttccggaac 3060aagtttgata tcgtgaagtg cagagaaatt
aacgattttc accatgctca cgacgcatac 3120ctgaatatcg tggtcggcaa
cgtgtataat accaagttca caaacaatcc ttggaacttt 3180atcaaggaga
aaagagataa tccaaagatt gctgacacct acaactacta taaggtgttc
3240gattatgacg tcaaaaggaa caatatcaca gcatgggaga aggggaaaac
tattatcacc 3300gtgaaagaca tgctgaagag aaacacacca atctacacta
ggcaggcagc ctgtaagaaa 3360ggggagctgt tcaatcagac cattatgaag
aaaggactgg gccagcaccc cctgaagaaa 3420gaaggacctt tttccaatat
ctctaaatac ggcgggtata acaaggtgag cgctgcatac 3480tatacactga
ttgagtatga ggaaaagggc aacaaaatcc gctccctgga aactattccc
3540ctgtacctgg tgaaagatat ccagaaggat caggacgtcc tgaagtctta
tctgacagac 3600ctgctgggga agaaagagtt caagatcctg gtgcccaaga
tcaagatcaa cagcctgctg 3660aagatcaatg ggtttccttg ccatattaca
ggaaaaacta acgatagttt cctgctgcgc 3720cctgccgtgc agttttgctg
ttcaaacaat gaggtcctgt acttcaagaa aattatccgg 3780ttttccgaaa
tccgctctca gcgagagaag atcgggaaaa caattagccc atacgaggac
3840ctgagcttcc ggtcatatat caaggagaac ctgtggaaga aaactaagaa
cgatgaaatc 3900ggagagaagg aattttacga cctgctgcag aagaaaaacc
tggagatcta tgatatgctg 3960ctgactaagc acaaagacac catctacaag
aaacgcccta attctgccac cattgatatc 4020ctggtgaagg ggaaagagaa
gttcaaaagc ctgattatcg aaaaccagtt tgaagtgatc 4080ctggagatcc
tgaagctgtt ttctgcaaca cggaatgtca gtgacctgca gcatatcgga
4140ggcagcaagt actccggcgt ggccaaaatc gggaacaaga tctctagtct
ggataactgt 4200atcctgatct atcagtccat caccggcatc ttcgagaaac
ggatcgacct gctgaaggtg 4260taagaattc 42691214179DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
121accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtccatgac caaggagtat tacctggggc tggatgtggg
gaccaattcc 120gtgggatggg cagtgaccga ttctcagtac aacctgtgca
agtttaagaa aaaggatatg 180tggggcatcc ggctgttcga aagcgccaac
acagcaaagg accggagact gcagagaggg 240aataggcgcc gactggagcg
gaaaaagcag agaattgatc tgctgcagga aatcttctcc 300ccagagatct
gcaagattga ccccactttc tttatccgac tgaacgaatc ccggctgcac
360ctggaggaca agtctaacga tttcaaatac ccactgttta ttgagaagga
ctattctgat 420atcgagtact ataaagagtt ccccaccatt tttcacctga
ggaagcatct gatcgagagt 480gaggaaaaac aggatatccg gctgatctac
ctggccctgc acaacatcat taagacccga 540ggacattttc tgattgacgg
cgatctgcag agcgccaagc agctgaggcc catcctggat 600acattcctgc
tgtccctgca ggaggaacag aacctgtcag tgagcctgtc cgaaaatcag
660aaggacgagt atgaggaaat tctgaaaaac cgcagcatcg ccaagtccga
aaaagtgaaa 720aagctgaaga atctgtttga gatctcagac gagctggaaa
aagaggagaa gaaggcccag 780agcgccgtga tcgagaactt ctgcaagttt
atcgtgggaa ataagggcga tgtctgtaaa 840ttcctgcggg tgtctaagga
ggaactggag attgactctt tcagtttttc agagggcaag 900tacgaggacg
acatcgtgaa aaacctggag gaaaaagtgc ctgaaaaggt ctacctgttt
960gagcagatga aggcaatgta tgattggaat attctggtcg acatcctgga
aaccgaggaa 1020tacatcagct tcgccaaagt gaagcagtat gagaaacaca
agactaacct gcggctgctg 1080agagacatca ttctgaaata ctgcaccaag
gatgagtata atcggatgtt taacgacgag 1140aaggaagctg gcagctacac
cgcatatgtg gggaaactga aaaagaacaa caagaagtac 1200tggatcgaga
aaaagagaaa tcccgaggag ttctacaaat ccctgggcaa gctgctggat
1260aaaattgagc ctctgaagga ggacctggaa gtgctgacta tgatgatcga
ggagtgtaag 1320aaccacaccc tgctgccaat tcagaaaaat aaggacaacg
gcgtgatccc ccaccaggtg 1380catgaggtcg aactgaaaaa gatcctggaa
aatgccaaaa agtactattc cttcctgacc 1440gagacagaca aggatgggta
ctcagtggtc cagaaaatcg agagcatttt caggtttcgc 1500atcccctact
atgtggggcc tctgagtacc cggcaccagg aaaagggatc aaacgtgtgg
1560atggtcagaa aacctggcag ggaggatcgc atctacccat ggaatatgga
ggaaatcatt 1620gactttgaga agagcaacga aaatttcatt acacggatga
ctaacaaatg tacatatctg 1680atcggggaag atgtcctgcc caagcattct
ctgctgtaca gtaaatatat ggtgctgaat 1740gagctgaaca atgtgaaggt
cagaggaaaa aagctgccta catctctgaa acagaaggtg 1800ttcgaggacc
tgtttgaaaa caaatccaaa gtgactggaa agaatctgct ggagtacctg
1860cagatccagg acaaagatat ccagattgac gatctgtctg gcttcgacaa
ggacttcaag 1920accagcctga agagctatct ggacttcaaa aagcagattt
ttggggagga aatcgagaag 1980gaaagcattc agaacatgat cgaagatatc
attaagtgga tcaccatcta cggcaatgac 2040aaggagatgc tgaaacgagt
gattcgggct aattatagca accagctgac agaggaacag 2100atgaaaaaga
tcactggatt tcagtacagt ggctggggga acttctcaaa gatgtttctg
2160aaagggatca gcggatccga cgtgagcacc ggcgaaacat tcgacatcat
taccgcaatg 2220tgggagacag acaacaatct gatgcagatc ctgtcaaaaa
agttcacctt tatggacaac 2280gtcgaggact tcaacagcgg caaggtcggg
aaaatcgaca agattactta cgatagcacc 2340gtgaaggaaa tgttcctgtc
ccctgagaac aaaagggccg tctggcagac cattcaggtg 2400gctgaggaga
tcaagaaagt gatgggctgc gagccaaaaa agatctttat tgaaatggca
2460cggggcgggg agaaggtgaa aaagaggaca aaatctcgca aggcccagct
gctggagctg 2520tacgccgctt gcgaggaaga ttgtagagaa ctgatcaagg
agattgagga ccgggacgag 2580agggacttca atagcatgaa gctgtttctg
tactataccc agttcgggaa atgtatgtat 2640tccggcgacg acatcgatat
taacgagctg attcgcggca attctaagtg ggaccgagat 2700cacatctacc
cccagagcaa aattaaggac gattccatcg ataacctggt gctggtcaat
2760aagacatata atgccaaaaa gtccaatgag ctgctgtctg aggacatcca
gaaaaagatg 2820cattcattct ggctgagcct gctgaacaaa aagctgatca
ctaaaagcaa gtacgaccgc 2880ctgactcgaa agggcgactt taccgatgag
gaactgagtg ggttcatcgc tagacagctg 2940gtggaaacaa ggcagtcaac
taaggcaatc gccgatatct tcaagcagat ctacagctcc 3000gaggtggtct
atgtgaagag cagcctggtg agcgacttca ggaaaaagcc actgaactac
3060ctgaagtctc ggagagtcaa tgattaccac catgcaaaag acgcctatct
gaacattgtg 3120gtcgggaacg tgtacaacaa aaagtttacc agtaatccca
tccagtggat gaaaaagaat 3180cgcgatacaa actatagcct gaacaaggtg
ttcgaacacg acgtggtcat taacggagaa 3240gtgatctggg aaaagtgcac
ataccatgag gacactaata cctatgatgg aggcactctg 3300gaccgaatcc
ggaagattgt ggaacgcgat aacattctgt acaccgagta cgcttattgt
3360gagaagggcg aactgtttaa tgcaaccatc cagaacaaaa atggaaactc
cacagtctct 3420ctgaaaaagg gcctggacgt gaaaaagtac gggggatact
tcagcgccaa cacaagttac 3480ttctcactga tcgagtttga ggacaagaag
ggggatagag caaggcacat cattggagtg 3540cctatctata ttgcaaacat
gctggagcat tctccaagtg ccttcctgga gtactgcgaa 3600cagaaggggt
atcagaatgt gcggattctg gtcgagaaaa tcaaaaagaa cagcctgctg
3660atcattaatg gataccctct gcgcattcga ggcgagaacg aagtggatac
ttcctttaag 3720agggccatcc agctgaagct ggaccagaaa aactatgagc
tggtccgcaa tatcgagaag 3780ttcctggaaa aatacgtgga gaaaaaggga
aactatccaa ttgacgagaa tagagatcac 3840atcacacatg aaaagatgaa
ccagctgtac gaggtgctgc tgtccaaaat gaaaaagttc 3900aacaagaagg
gcatggccga cccctctgat aggatcgaaa agagtaagcc taaattcatc
3960aagctggagg acctgatcga taagattaat gtgatcaaca aaatgctgaa
cctgctgcgc 4020tgtgacaatg atactaaggc cgacctgtct ctgattgagc
tgcccaaaaa cgctgggagt 4080ttcgtggtca aaaagaatac catcggaaag
tcaaaaatca tcctggtgaa tcagagcgtg 4140actggactgt acgagaatag
acgggaactg taagaattc 41791224086DNAArtificial SequenceDescription
of Artificial Sequence Synthetic polynucleotide 122accggtgcca
ccatgtaccc atacgatgtt ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag
cgtccatggg gaggaaacct tacattctgt ctctggatat tggaactggg
120tccgtcggct acgcttgcat ggataaagga ttcaacgtgc tgaagtacca
cgacaaagat 180gccctgggag tgtatctgtt cgacggcgct ctgactgcac
aggagcggag acagtttagg 240acctccaggc gccgaaagaa ccggagaatc
aaacgcctgg gcctgctgca ggaactgctg 300gcacccctgg tgcagaaccc
taatttctac cagtttcagc ggcagttcgc ctggaagaac 360gacaatatgg
attttaagaa caagagcctg tctgaggtgc tgagcttcct gggatatgaa
420tccaagaaat accctaccat ctaccacctg caggaggctc tgctgctgaa
agacgagaag 480tttgatccag aactgatcta catggcactg tatcatctgg
tgaaatacag aggccacttt 540ctgttcgatc atctgaagat cgagaacctg
actaacaatg acaatatgca cgatttcgtg 600gagctgattg aaacctatga
gaacctgaac aatatcaagc tgaatctgga ctacgagaaa 660accaaagtga
tctatgagat tctgaaagac aacgaaatga ctaagaatga tagagccaaa
720agggtcaaga acatggagaa gaaactggaa cagttctcta tcatgctgct
ggggctgaag 780ttcaatgagg gaaaactgtt taaccacgcc gataatgctg
aggaactgaa gggggctaac 840cagagccata catttgcaga caactacgag
gaaaatctga ctcccttcct gaccgtggaa 900cagtcagagt ttattgaaag
ggccaacaaa atctatctga gcctgactct gcaggatatc 960ctgaagggca
agaaatcaat ggctatgagc aaagtggccg cttacgacaa gttcagaaat
1020gagctgaaac aggtgaagga cattgtctat aaggctgatt ctaccaggac
acagttcaag 1080aaaatctttg tgagctccaa gaaaagtctg aagcagtacg
acgcaactcc caacgatcag 1140accttctcta gtctgtgcct gtttgaccag
tacctgattc gcccaaagaa acagtatagc 1200ctgctgatca aggagctgaa
gaaaatcatt ccccaggact ccgaactgta ctttgaggca 1260gaaaatgata
ccctgctgaa ggtgctgaac accacagaca atgctagcat ccctatgcag
1320attaacctgt acgaggcaga aaccatcctg cgaaatcagc agaaatatca
cgccgagatc 1380acagatgaga tgattgaaaa ggtgctgtct ctgatccagt
tccgcattcc atactatgtg 1440gggcccctgg tcaacgacca tacagccagt
aagtttggat ggatggagcg caaaagtaac 1500gaatcaatca agccttggaa
tttcgacgag gtggtcgatc gaagtaaatc agccactcag 1560tttattaggc
gcatgaccaa caagtgttcc tacctgatca atgaggatgt gctgccaaaa
1620aactctctgc tgtatcagga gatggaagtc ctgaacgaac tgaatgccac
acagatcagg 1680ctgcagactg acccaaaaaa ccgcaagtac cgaatgatgc
cccagattaa gctgttcgct 1740gtggagcaca tctttaagaa atataaaacc
gtcagccatt ccaagttcct ggaaattatg 1800ctgaacagca atcacaggga
gaactttatg aatcatggag aaaagctgag tatcttcggc 1860acacaggacg
ataagaaatt tgcatcaaag ctgtcaagct accaggacat gactaaaatc
1920ttcggggata ttgagggaaa gcgcgcccag attgaggaaa tcattcagtg
gatcaccatt 1980tttgaggaca agaaaatcct ggtgcagaag ctgaaagagt
gctatcctga actgacatcc 2040aagcagatca accagctgaa gaaactgaat
tactctggct gggggaggct gagtgagaag 2100ctgctgactc acgcctatca
gggccatagc atcattgaac tgctgcgcca ctccgatgag 2160aatttcatgg
aaattctgac caacgacgtg tacgggttcc agaattttat caaagaggaa
2220aaccaggtcc agagcaataa gatccagcat caggatattg ccaacctgac
tacctctccc 2280gctctgaaga aaggcatctg gagtacaatt aagctggtgc
gggagctgac ttccattttc 2340ggggagcctg aaaagatcat tatggagttt
gctaccgagg accagcagaa aggcaagaaa 2400cagaaatcaa gaaagcagct
gtgggacgat aacatcaaga aaaataagct gaaaagcgtg 2460gacgagtaca
aatatatcat tgatgtcgcc aataagctga acaatgagca gctgcagcag
2520gaaaaactgt ggctgtacct gagccagaac ggcaagtgta tgtatagcgg
gcagtccatc 2580gacctggatg ccctgctgtc ccccaatgct accaagcact
acgaggtgga tcatattttc 2640cctcggagct tcatcaagga cgatagcatt
gacaacaagg tgctggtcat caagaaaatg 2700aatcagacaa agggcgatca
ggtgcccctg cagttcattc agcagcctta cgagagaatc 2760gcatattgga
agagcctgaa caaagccggg ctgatctctg atagtaaact gcacaagctg
2820atgaaaccag agttcacagc tatggacaag gaaggcttca tccagcggca
gctggtggag 2880actagacaga tcagcgtgca tgtccgggat tttctgaaag
aggaataccc taataccaaa 2940gtgatcccaa tgaaggccaa aatggtgagc
gagttccgga agaaatttga catcccaaag 3000attagacaga tgaacgacgc
acaccatgcc atcgatgctt acctgaatgg cgtggtctat 3060cacggggcac
agctggccta ccccaacgtg gacctgtttg atttcaattt taagtgggag
3120aaagtccgag aaaagtggaa agccctggga gagttcaaca caaagcagaa
atctcgggaa 3180ctgttctttt tcaagaaact ggagaagatg gaagtgtccc
agggcgagcg gctgatctct 3240aagatcaagc tggacatgaa ccacttcaag
atcaactact ccagaaagct ggccaacatc 3300cctcagcagt tttataatca
gaccgcagtg tctccaaaga cagccgagct gaaatacgaa 3360tctaacaaga
gtaatgaggt ggtctataag ggactgacac cataccagac ttatgtggtc
3420gccatcaaga gcgtgaacaa gaaaggcaag gagaaaatgg aataccagat
gatcgaccac 3480tacgtgttcg atttttataa attccagaac ggcaatgaga
aggaactggc tctgtacctg 3540gcacagaggg agaacaagga cgaagtgctg
gatgctcaga ttgtctatag tctgaataag 3600ggggatctgc tgtacatcaa
caatcatccc tgctatttcg tgtcacgcaa agaggtcatc 3660aacgcaaagc
agtttgagct gaccgtggaa cagcagctgt ctctgtacaa cgtgatgaac
3720aacaaggaga caaatgtcga aaagctgctg atcgagtatg acttcattgc
cgagaaagtg 3780atcaacgaat accaccatta tctgaatagc aagctgaaag
aaaagcgagt ccggaccttt 3840ttctcagaga gcaaccagac acacgaggac
ttcatcaagg ccctggacga gctgtttaag 3900gtggtcaccg catccgccac
aaggtctgat aaaatcggga gtcgcaagaa cagcatgact 3960catcgagcct
tcctgggaaa aggcaaggac gtgaagattg cttacacctc catctctgga
4020ctgaaaacaa ctaaacctaa gagtctgttt aagctggccg agtcaagaaa
cgaactgtaa 4080gaattc 40861234209DNAArtificial SequenceDescription
of Artificial Sequence Synthetic polynucleotide 123accggtgcca
ccatgtaccc atacgatgtt ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag
cgtccatgac aaaaatcaaa gacgactaca tcgtgggact ggacatcggc
120acagactcct gcgggtgggt ggctatgaac agcaataatg acattctgaa
actgcagggc 180aagaccgcaa tcgggtcacg cctgttcgag ggagggaaga
gcgcagctga acggagactg 240tttcgcacca cacacaggcg catcaaacga
cggagatggc gactgaagct gctggaggag 300ttcttcgacc cctacatggc
agaggtggat ccttatttct ttgcccggct gaaggaatct 360ggcctgagtc
cactggacaa aagaaagacc gtgagctcca ttgtgttccc cacatccgcc
420gaggataaga agttctacga cgattaccct acaatctacc atctgaggta
taaactgatg 480actgaggacg aaaagttcga tctgcgcgaa gtgtacctgg
ctatccacca tatcattaag 540taccgaggaa acttcctgta taataccagt
gtgaaagact tcaaggcatc aaagatcgat 600gtcaaatcta gtatcgagaa
gctgaacgag ctgtatgaaa atctgggcct ggacctgaac 660gtggagttca
acattagcaa tactgccgag atcgaaaagg tgctgaaaga caagcagatc
720ttcaagcggg ataaagtcaa gaaaattgcc gagctgtttg ctatcaaaac
cgacaacaag 780gaacagagca agagaatcaa agatatttcc aaacaggtgg
ccaatgctgt cctggggtac 840aagaccaggt tcgacacaat cgctctgaaa
gagatttcca aggacgaact gtctgattgg 900aacttcaaac tgtcagacat
cgatgcagac agcaagtttg aggccctgat gggaaacctg 960gatgagaatg
aacaggccat cctgctgact attaaggagc tgtttaacga agtgaccctg
1020aatggaattg tcgaggacgg caacaccctg agcgaatcca tgatcaacaa
gtacaatgat 1080caccgggacg atctgaagct gctgaaagaa gtgatcgaaa
atcatattga cagaaagaaa 1140gccaaggagc tggcactggc ctacgatctg
tatgtcaaca ataggcacgg acagctgctg 1200caggctaaga aaaagctggg
caaaatcaag ccccgctcta aggaggactt ctacaaagtg 1260gtcaacaaga
atctggacga ttcacgggca agcaaggaga tcaaaaagaa aattgaactg
1320gacagcttta tgcctaagca gagaaccaac gccaatggcg tgatcccata
ccagctgcag 1380cagctggagc tggataagat catcgaaaac cagtctaagt
actatccatt cctgaaggag 1440attaatcccg tgtcaagcca cctgaaagag
gccccctata agctggacga actgatccga 1500tttcgggtgc cttactatgt
cggccccctg atttctccta acgagagtac caaggatatc 1560cagacaaaga
aaaaccagaa tttcgcctgg atgattcgca aagaggaagg gcgaatcaca
1620ccttggaact ttgaccagaa ggtggatcga attgagagcg ccaataagtt
catcaaacgg 1680atgactacca aggacactta cctgtttggg gaggatgtgc
tgccagctaa cagcctgctg 1740tatcagaagt tcaccgtcct gaacgaactg
aacaacatcc ggattaatgg aaaaagaatc 1800tccgtggacc tgaagcagga
gatctacgaa aacctgttta agaaacacac aactgtgacc 1860gtcaagaaac
tggagaatta tctgaaggaa aaccataatc tggtgaaagt cgagatcaag
1920gggctggccg atgaaaagaa attcaacagc ggactgacca catacaatag
attcaagaac 1980ctgaacatct ttgacaacca gattgacgat ctgaagtaca
ggaacgattt cgagaagatc 2040atcgaatggt ctacaatttt tgaggacaag
agtatctaca aagaaaagct gaggagcatc 2100gattggctga acgagaagca
gattaacgct ctgtctaata tcagactgca ggggtgggga 2160aggctgagta
agaaactgct ggcacagctg cacgaccata atggccagac catcattgag
2220cagctgtggg attcccagaa caatttcatg cagattgtga cacaggccga
ctttaaagat 2280gctatcgcaa aggccaacca gaatctgctg gtggctacct
cagtcgagga cattctgaac 2340aatgcataca caagccccgc aaacaagaaa
gccatcagac aggtcatcaa ggtggtcgac 2400gatatcgtga aggcagcctc
cggaaaggtc ccaaaacaga tcgccattga gttcactagg 2460gatgctgacg
aaaatcccaa gagaagtcag accaggggct caaagctgca gaaagtgtac
2520aaggacctga gcactgagct ggcctccaag accattgctg aggaactgaa
cgaagcaatc 2580aaagacaaga aactggtgca ggataagtac tatctgtact
ttatgcagct ggggcgggac 2640gcctatacag gagagcctat caatatcgat
gaaatccaga agtacgatat cgaccacatt 2700ctgccacagt ctttcatcaa
ggacgatgcc ctggacaaca gggtgctggt gagccgggct 2760gtgaacaatg
gcaaatctga taatgtgcct gtcaagctgt ttggcaacga gatggctgca
2820aatctgggga tgactatcag gaaaatgtgg gaggaatgga agaacatcgg
cctgattagc 2880aaaacaaagt acaacaatct gctgactgat cccgaccaca
ttaacaagta taagagtgcc 2940gggttcatca ggcgccagct ggtggagaca
tcacagatca tcaagctggt gagcactatc 3000ctgcagagtc gctaccctaa
cactgaaatc attaccgtga aggctaagta caatcattat 3060ctgcgggaga
aatttgacct gtataagagc agagaagtca acgactacca ccatgctatt
3120gatgcatatc tgtccgccat ctgcggaaat ctgctgtacc agaactatcc
aaatctgcgg 3180cccttctttg tgtacggcca gtataagaaa ttctcctctg
atcctgacaa agagaaggcc 3240atttttaaca aaacccgcaa gttctccttt
atctctcagc tgctgaaaaa caagagtgag 3300aacagcaagg aaatcgctaa
gaaactgaaa cgggcatacc agttcaagta tatgctggtg 3360tctcgagaga
ctgaaacccg ggaccaggag atgttcaaaa tgaccgtgta cccccggttc
3420agccacgata cagtcaaggc tcctaggaac ctgattccaa agaaaatggg
catgtcccct 3480gacatctacg gaggctatac aaacaattct gacgcataca
tggtcatcgt ccgcattgat 3540aagaaaaagg gaactgagta taagatcctg
ggcattccaa cccgggaact ggtgaatctg 3600aaaaaggccg agaaggagga
ccattacaaa agctatctga aggagatcct gacaccaagg 3660attctgtaca
acaaaaatgg gaagcgcgat aaaaagatca cttccttcga aattgtgaaa
3720tctaagatcc cctataagca ggtcatccag gatggggaca aaaagtttat
gctgggaagt 3780tcaacatacg tgtataacgc aaagcagctg acactgagca
ctgagtccat gaaagccatc 3840actaacaatt tcgataagga cagcgatgag
aacgacgctc tgattaaggc atacgatgaa 3900atcctggaca aagtggataa
gtatctgcca ctgttcgaca tcaacaagtt ccgggagaag 3960ctgcacagtg
ggcgagaaaa gttcatcaag ctgagcctgg aggacaaaaa ggataccatc
4020ctgaaagtgc tggaaggact gcatgataac gctgtcatga caaagatccc
tactattggc 4080ctgtccacac cactggggtt catgcagttt cccaacggcg
tgattctgag cgagaatgcc 4140aaactgatct accagtcccc caccgggctg
ttcaaaaagt cagtgaagat cagcgacctg 4200taagaattc
42091243405DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 124accggtgcca ccatgtaccc atacgatgtt
ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag cgtccatggg ctacactgtg
ggactggata ttggggtggc ttccgtcggg 120gtggctgtgc tggatgagaa
tgacaacatc gtggaggctg tgtcaaacat ctttgatgaa 180gccgacacaa
gcaacaataa ggtgcggaga actctgaggg agggcaggcg cacaaagcgg
240cggcagaaaa cccgcattga ggacttcaag cagctgtggg agacttcagg
ctacatcatt 300cctcacaagc tgcatctgaa tatcattgag ctgcgcaaca
aagggctgac cgaactgctg 360agcctggatg agctgtattg cgtgctgctg
tccatgctga agcaccgggg gatctcctac 420ctggaggacg ccgacgatgg
cgagaagggg aatgcctata agaaaggact ggcttttaac 480gaaaaacagc
tgaaggagaa aatgccatgt gagatccagc tggaacgcat gaagaaatac
540gggaagtacc atggagagtt catcatcgaa attaatgatg agaaggaata
ccagagcaac 600gtgttcacca caaaggctta taagaaggag ctggaaaaga
tcttcgagac acagcggtgc 660aacggcaaca agatcaacac aaagttcatt
aagaaataca tggagatcta cgaacgaaag 720cgggaatact atatcggacc
aggcaatgag aaaagcagaa cagactacgg catctatact 780accaggactg
atgaggaagg gaatttcatc gacgagaaga acatttttgg caaactgatc
840gggaagtgta gtgtgtaccc cgaggaatat agagcaagct ccgcctcata
caccgcccag 900gagttcaatc tgctgaacga tctgaacaat ctgaaaatca
acaatgagaa gctgacagaa 960tttcagaaga aagagattgt cgaaatcatt
aaggacgctt ctagtgtgaa catgaggaaa 1020atcattaaga aagtcatcga
tgaggacatt gaacagtaca gcggagcacg aatcgataag 1080aaaggcaagg
aaatctacca caccttcgag atctatcgga agctgaagaa agagctgaaa
1140acaatcaatg tggatatcga ctcttttact agagaggaac tggataagac
catggacatc 1200ctgaccctga acacagagag ggaaagtatt gtgaaggcct
tcgacgaaca gaaatttgtc 1260tacgaggaaa atctgatcaa gaaactgatt
gagtttcgga agaacaatca gagactgttc 1320agcggctggc atagtttttc
atacaaggct atgctgcagc tgatcccagt gatgtacaag 1380gagcccaaag
aacagatgca gctgctgacc gaaatgaacg tgttcaaaag taagaaagag
1440aagtacgtca actacaagta catcccagag aacgaagtgg tcaaggagat
ctataacccc 1500gtggtcgtga agagcattag aacaactgtg aaaattctga
atgcactgat caagaaatac 1560gggtatcctg aatccgtcgt gatcgagatg
ccaagggata agaactctga cgatgagaag 1620gaaaagatcg acatgaacca
gaagaaaaac caggaggaat acgagaaaat cctgaacaag 1680atctacgatg
agaagggaat cgaaattacc aacaaggact acaagaaaca gaagaaactg
1740gtgctgaagc tgaaactgtg gaacgagcag gaaggactgt gcctgtattc
cggcaagaaa 1800atcgctattg aggatctgct gaatcacccc gagttctttg
aaattgacca tatcattcct 1860aagagcatct ccctggacga ttctcgcagt
aacaaggtcc tggtgtacaa aacagaaaat 1920tctatcaagg agaacgatac
cccctaccac tatctgacac ggattaacgg aaagtggggc 1980tttgacgaat
ataaagctaa tgtgctggag ctgagaaggc gcggcaagat cgacgataag
2040aaagtgaaca atctgctgtg catggaggat atcactaaga ttgacgtcgt
gaaagggttc 2100attaaccgca atctgaacga caccagatac gcatccaggg
tggtgctgaa cgaaatgcag 2160tccttctttg agtctcgaaa gtactgtaat
actaaggtca aagtgatccg aggctctctg 2220acctatcaga tgcggcagga
tctgcacctg aagaaaaaca gagaggaatc atacagccac 2280catgctgtgg
acgcaatgct gatcgcattc tcccagaagg ggtacgaggc ctataggaag
2340atccagaaag attgctacga ctttgagaca ggcgaaattc tggacaagga
aaaatggaat 2400aagtacattg acgatgacga gtttgatgac atcctgtata
aagagaggat gaacgaaatc 2460cgcaagaaaa tcattgaggc cgaggaaaag
gtgaagtaca actacaagat cgataagaag 2520tgcaatcgcg ggctgtgtaa
ccagactatc tacgggaccc gagaaaagga cggaaaaatc 2580cacaagattt
caagctacaa catctatgat gacaaggagt gtaattccct gaagaaaatg
2640attaacagtg ggaaaggatc agatctgctg atgtacaaca atgatcctaa
gacatatcgc 2700gacatgctga aaatcctgga aacttactcc tctgagaaga
atccattcgt ggcatataac 2760aaagagacag gagactactt tcggaaatat
tctaagaatc acaacggacc caaggtcgag 2820aaggtgaaat actatagcgg
ccagatcaac tcctgcatcg atatttctca caagtacggc 2880catgccaaaa
atagtaagaa agtcgtgctg gtgtcactga acccttatag aaccgacgtc
2940tactatgata atgacacagg caagtactat ctggtcgggg tgaagtacaa
tcatatcaaa 3000tgtgtcggaa acaagtacgt gattgatagc gagacatata
acgaactgct gaggaaggag 3060ggcgtgctga acagcgatga gaacctggag
gacctgaaca gcaaaaacat cacttacaag 3120ttcagtctgt acaagaacga
catcatccag tacgagaagg gcggggaata ctatacagag 3180cgctttctga
gccgaatcaa agaacagaag aacctgattg agactaaacc catcaataag
3240cctaacttcc agcggaagaa taagaaaggc gagtgggaaa ataccagaaa
ccagatcgcc 3300ctggctaaga ctaaatacgt ggggaagctg gtcaccgatg
tgctgggaaa ctgttacatc 3360gtgaacatgg agaagttctc cctggtcgtg
gacaaataag aattc 34051253474DNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotide 125accggtgcca
ccatgtaccc atacgatgtt ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag
cgtccatgac taacggcaag attctggggc tggacattgg catcgcaagc
120gtgggggtgg ggattattga ggcaaaaact ggaaaggtgg tgcatgccaa
ttcccggctg 180ttctctgccg ctaacgctga gaacaatgca gaacggagag
ggtttagggg atctaggcgc 240ctgaatcgac ggaagaaaca ccgcgtgaag
cgagtccggg atctgttcga gaaatacgga 300atcgtcaccg actttcgcaa
cctgaatctg aacccttatg agctgcgagt gaagggcctg 360accgaacagc
tgaaaaacga ggaactgttc gcagccctga gaacaatctc taagagaagg
420gggattagtt acctggacga tgccgaggac gatagtaccg gatcaacaga
ctatgctaag 480agcatcgatg agaatcgccg actgctgaaa aacaagacac
caggccagat tcagctggag 540aggctggaaa agtacggcca gctgcgcggg
aatttcaccg tctatgacga gaacggggaa 600gcccatcgcc tgatcaatgt
gtttagtaca tcagattacg agaaagaagc acggaagatc 660ctggagacac
aggccgacta caacaagaaa atcacagctg agttcattga cgattatgtg
720gaaatcctga cccagaaacg aaagtactat cacggccccg ggaacgaaaa
gagccggact 780gactacggac ggttccggac cgatgggacc acactggaga
atattttcgg aatcctgatt 840ggcaagtgca acttttaccc tgatgaatat
cgagcaagca aggccagcta caccgcacag 900gagtataatt tcctgaacga
cctgaacaat ctgaaggtga gcaccgaaac agggaagctg 960tcaacagagc
agaaagaaag cctggtggag tttgccaaga atactgctac cctgggaccc
1020gctaaactgc tgaaggagat cgcaaaaatt ctggactgta aggtggatga
gatcaaagga 1080tacagagagg acgataaagg caagccagat ctgcatacct
tcgagcccta taggaaactg 1140aagtttaatc tggaaagcat caacattgac
gatctgtccc gcgaagtgat cgacaagctg 1200gctgatattc tgactctgaa
caccgagaga gaaggaatcg aggacgcaat taagaggaat 1260ctgccaaacc
agttcacaga ggaacagatc agcgagatca tcaaggtgcg gaagagccag
1320tccactgctt tcaataaggg ctggcactct tttagtgcaa aactgatgaa
cgagctgatc 1380cccgaactgt acgccacctc cgacgagcag atgacaattc
tgactcggct ggaaaaattc 1440aaggtcaata agaaaagctc caaaaacaca
aagactatcg acgagaagga agtcactgat 1500gagatctaca atcctgtggt
cgccaagagc gtgagacaga ccatcaaaat cattaacgct 1560gcagtcaaga
aatatggcga cttcgataag atcgtgattg aaatgccacg ggataaaaat
1620gctgacgatg agaagaagtt catcgacaag agaaataagg agaacaagaa
ggaaaaggac 1680gatgccctga aaagggccgc ttacctgtat aattctagtg
acaagctgcc cgatgaggtg 1740ttccacggca acaagcagct ggaaaccaaa
atccgactgt ggtatcagca gggggagcgg 1800tgcctgtata gtggaaagcc
catctcaatt caggagctgg tgcataactc taacaatttc 1860gaaatcgatc
acattctgcc tctgtcactg agctttgacg atagtctggc caataaggtg
1920ctggtctacg cttggacaaa ccaggagaaa ggccagaaaa ccccttatca
ggtcatcgac 1980tccatggatg cagcctggtc tttcagggag atgaaggact
acgtgctgaa acagaaggga 2040ctgggcaaga aaaagcgcga ctatctgctg
actaccgaga acatcgataa gattgaagtg 2100aagaagaagt tcatcgagag
gaatctggtg gatactcgct acgcatctcg agtggtcctg 2160aactctctgc
agagtgccct gagagagctg gggaaagaca ctaaggtgtc tgtggtcagg
2220ggacagttca ccagtcagct gcggagaaaa tggaagatcg ataagagccg
cgagacatac 2280caccatcacg cagtggacgc cctgatcatt gctgcatcaa
gccagctgaa actgtgggag 2340aagcaggaca atcccatgtt tgtggattat
ggcaagaacc aggtggtcga caaacagact 2400ggggagatcc tgtccgtgtc
tgacgatgag tacaaggaac tggtgttcca gcccccttat 2460cagggctttg
tgaataccat ctcctctaaa gggttcgagg acgaaattct gtttagctac
2520caggtggatt ccaaatataa ccggaaggtc agtgacgcaa ccatctactc
aacaagaaaa 2580gccaagattg gcaaggataa gaaagaggaa acctacgtgc
tgggaaaaat caaggacatc 2640tactcccaga atggcttcga taccttcatc
aagaagtaca acaaagataa gactcagttc 2700ctgatgtatc agaaggactc
tctgacatgg gagaacgtga tcgaagtcat tctgagggac 2760tacccaacaa
ctaagaaaag cgaggacggc aaaaatgatg tgaagtgcaa cccctttgag
2820gaatacaggc gcgagaatgg gctgatctgt aagtattcca agaaagggaa
aggaactccc 2880atcaagagcc tgaagtacta tgacaagaaa ctggggaact
gcatcgatat taccccagag 2940gaatcacgca ataaggtcat cctgcagagc
attaaccctt ggcgagccga cgtgtacttc 3000aatccagaga cactgaagta
cgaactgatg ggcctgaaat attcagatct gagctttgaa 3060aagggcactg
ggaactacca tatcagccag gagaaatatg acgctatcaa agagaaggaa
3120ggaattggca agaaatccga gttcaagttt acactgtacc gcaacgacct
gatcctgatc 3180aaggatatcg ccagtggcga gcaggaaatc tacagattcc
tgtcaagaac tatgcccaat 3240gtgaaccact acgtcgagct gaagccttac
gacaaggaaa agttcgataa cgtgcaggag 3300ctggtcgaag cactgggaga
ggcagataaa gtgggacgat gtatcaaagg actgaataag 3360ccaaacatca
gcatctacaa ggtgagaacc gacgtcctgg gaaacaaata tttcgtgaag
3420aaaaagggcg acaaacccaa gctggatttt aagaacaaca agaagtaaga attc
34741263462DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 126accggtgcca ccatgtaccc atacgatgtt
ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag cgtccatggc cgaccgaatc
tctctggggc tggacattgg ggtggcaagc 120gtggggttct cagtgctgga
cattgataag ggaaaagtca ttgagctggg cgccaggctg 180ttctctgcta
ctgtggccgc tggcaaccag gatcgaagag acatgcgagg agccaggcgc
240ctgctgaacc ggaacaagca gcgacggcag gataccggaa agctgttcaa
gaaatttggc 300ctgatcgacg attttgataa gggcagcttc tacgacaact
ttaatcagaa cctgaatcct 360tatgagctga gagtgaaagg cctgacagaa
cagctgacta aggaggaact ggccgagtct 420ctgtaccaga tcgtgaaaca
tagggggatt agttatgcac tgaaggacgc cgatgtggac 480gaaggcggga
cagactactc agtcagcctg aaaatcaaca gccaggagct ggcagaaaag
540actccagccc agattcagct gcagagactg aatgattatg gaaaggtgag
gggccaggtg 600gtcatcggcg acgatccaga caaccagaag gtgctgctga
atgtgttccc cacatcagct 660tacgagaaag aagcaaagca gatcattgcc
actcagcagc agttctatcc tgagagcctg 720accgacaagt tcaccgagga
atactgccag atcctgactc gcaagcgaga ttattttgtg 780gggccaggaa
acgagaaaag ccggaccgac tacgggatct acaagactga tggaagaacc
840ctggacaatc tgttcgagga actgatcggc cacgataaga tctaccccga
ggaactgcgg 900gcatctgcag ccagttatac cgcccagctg tttaacgtgc
tgaatgacct gaacaatctg 960agaatcctga actacgagga tgggaaactg
acaaaggagg acaaggaaaa gatcatcgct
1020gaaattaaga acaacaccac aactatcaac atgctgaatg tgattaagaa
agtcgccggg 1080tgttccaagg acgatatcaa aggattccga gtgaatgaga
aggataaacc cgaaatcagc 1140tccatgcctg tgtaccgcaa aattcataag
gacctgctga aggccggcgt ggatatctca 1200gactggcccg tcgagttcat
cgacgaactg agctttattc tgacactgaa cactgagaat 1260ggggaaattc
gcaaacagct gaacaatcga ctggccccta agttcgattt tctgaacgct
1320gacctgatcc agctgatcat tgataataag gactcctttg agattaagac
taacaacaag 1380tggcacagat tcagcgtgaa aaccatgaac aaactgatcc
cagagatgat ggaaagaccc 1440gtggagcaga tgaccctgct gaatgaaatg
ggactggtca agaaagataa gaaacgcttt 1500gagaacaata agtacctgcc
ttacaaggaa atcgcaaagg acattttcaa cccagtggcc 1560tccaaatctg
tccgcgaggc cctgaagatc gtgaatgctg tcctgaagaa atacggccac
1620attgattatc tggtggtcga aatgcctcgg gataaaaacc tgaaggagga
acaggacaat 1680atcaaggagt tccagaacaa aaataagaaa gctaaggacg
ctgcattcga agcatttgtg 1740aaatcagtcg ggagcgagca gagagtgaag
gaagccctgt ctaaaaaccg gaagctgcag 1800atgaagatga gactgtggta
tcagcagcag gagatcgatc catataatgg aaagacaatc 1860gatgccactg
acctgattaa caatcctgat aagttcgaga ttgaccatat cattccacag
1920agtatctcat tttacgacag tattaacaat aagaccctgt gcttcgcctc
aatgaaccag 1980gtgaaaggac agaaaacccc ctacgagttt atgctggaag
gccacgggca gtcctatgac 2040aagttcaaag ctacagtgat ggcaaacaag
aattttggca aggctaaaag ggcaaactac 2100ctgttcgagg aaaatgtgag
cgatatcgag actcggaaga gattcctgtc ccgcaacctg 2160gtggacaccc
gatattctag tcgggtggtg ctgaacagcc tgcaggattt ctttcgggag
2220aaatctgccg acaccaaggt gacagtcatt cgcggcaagt ttacctccaa
catgcgaaaa 2280cattggcaca tcgataagac tagggagaca ttccaccatc
acgccattga cgcttctatc 2340attgccgcta caccatttct gcgcatgtgg
aagaaaggag gcactatctt ccccgtgaag 2400gtcggagaag aaagtatcga
tattgagaca ggcgaaattc tggacgataa gaattttgac 2460aaagcaatgt
acgaggaacc ctatagtggc ttcgtgtcag agatcatgaa cgccgacgat
2520cggatcaagt tcagccacca ggtggataag aaaatgaata ggaaggtgag
cgacgccacc 2580atctacagta ctcgcaccgg gaaactggct aaggataaga
aagacgctga gtacatcgtg 2640gcaaaggtca aagatatcta cagcgtggac
ggattcaaga agttcaagaa agtctacgat 2700aaggacaaaa ccaagtttct
gctgtacaaa tatgatccta ggacattctc aaagctggag 2760cgcatcatta
gcgattgccc agacaaagtg gaaaaggtcc agacaaacgg caaagtgaag
2820gctgtcgata tcagtccatt cgagatgtac agaagggacc atgggatgat
caagaaatac 2880tcaaagaaag gaaacggccc cgccatcaag cagctgaagt
acctggataa gaaactgggc 2940agccacatcg acattacccc cgcaaacgcc
aatggaaaac acgtgatcct gcagagtctg 3000aagccttgga gaaccgacgt
ctatctgaac cacgagacag gcgagtacga aatcatgggg 3060attaagtata
gcgatctgaa gttcaacaag aatgaggggt acggaatcaa gaaagacaag
3120tatctggaaa ttaagaaagt ggaggaagtc tccgagaagt ctgagttcat
gtttagcctg 3180tacaggaagg atcgcgtgaa agtccaggac atgaaaaccg
gcgagtccgt ggaactgctg 3240ttctggagca ggaacttttc caataagaaa
tacgctgagc tgaagcccat ctcccaggca 3300gaaaacgaca agaaactgcc
tgtgtatggc aaagggagac tgatcaagag gctgattccc 3360aaaaactgta
agatctggaa agtgaatacc acaattctgg gcgatcccta ctatctggag
3420aaagaaagcg actcccctaa ggatatcctg gactaagaat tc
34621274611DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 127accggtgcca ccatgtaccc atacgatgtt
ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag cgtccatgaa gaaaacactg
ggactggacc tggggactaa cagcattggg 120tgggccgtca tcaactcaaa
catcgactca gaaggaaaag aaaagctggt ggggatcagc 180tcctgcggaa
gccggatcat tcctatggac gctaccacac tgggagattt cggaaagggc
240aacactaaaa gtccagtggc agagcgaacc cgactgcggg gcattcggag
actgctggaa 300aggtcactgc tgaggcgcga gcgactgcac cgagtgctgt
cagtcatggg gttcctgcca 360gagcattacg ctagccagct ggaccgctat
ggaaagtttc tgccagaaac cgagcccaag 420ctggcatggt acaaagacga
tagcggcagg tatcagttcc tgtttcagaa gtccttccac 480gagatgctgg
aggactttcg acagcatcag ccagaactgg tggcaggaga gaagaaaatc
540ccttacgatt ggacaatcta ctatctgcgg aagaaagcac tgtctcagga
gatcactaag 600gaggaactgg cctggattct gctgaatttc aaccagaaac
gcggctacta tcagctgcga 660ggggaggaag agcaggaaga gaacaataag
agcgtggagt atcacgccct gaaagtggtg 720agcgtcgagg actctggaga
aagaaagggc aaagatatct ggtacaatgt gactctggag 780aacggatggg
tctatcgacg ggctagcaac attcccctgg actggaccgg caaggtgaaa
840gagttcgtgg tcactaccga gctggacgat gccgggaacc caaagaaaga
taaggaagga 900aatgtgaaaa gatcctttag ggcaccaaag gaggacgatt
gggggctgct gaaaactagg 960acccaggctc agatcgacga atccggcaag
accgtgggaa cttacatcta cgagtctctg 1020ctgtgtatgc ccaaccagaa
gatccgggga aaactggtga ggaccattga acgcaagtac 1080tataaagacg
agctgagaca gatcctggtg aagcagagcg agttccacgc cgctctgcag
1140gatcataatc tgctgctgtc ctgtatcgaa gagctgtacc ctaacaatga
ggcccacaga 1200aggctgctga gcgccagcag cttcatctac ttcctgatcg
aggacattct gttttatcag 1260cgcccactga agtcccagaa agggctgatc
gataactgcc cctacgagtc tcacatctac 1320aaggataaga aagatggaag
tctgcaccat gtgcctctga agtgtgtcag caaatcccat 1380ccactgttcc
aggaatttcg cctgtggcag ttcctgtcta acctgcgaat ctaccagaga
1440gagaggatga tggacggcag tctgaaactg gacgtggatg tcacccggga
gttcctgccc 1500tcagaagagg actacgtgaa gctgtttgat tggctgaatg
agagaaagga aatctctcag 1560aaattcctgc tggcttataa accttttggg
ctgaagaaaa acgaacaggc aaattacaga 1620tggaactatg tggaggacaa
gagctacccc tgcaacgaga cacgggcaga aatcaagagc 1680agactgtcca
aagccggagt gcctgaagag tttctgactg aagagaagga agaggccctg
1740tggcacatcc tgtattctat tagtgataag aaagagctga ctaaggctct
gggcaccttc 1800gcagccaaaa actgtctgaa tgagtctttc gtggaagtct
ttgccaagat cccccctttt 1860gagtcaaact acgctgcata tagcctgaag
gctattagga aactgctggc actgatgcgc 1920atggggaagt actggaatga
acaggccatc gacaggcaga ctcgcgatcg aatcgagaaa 1980attctgaccg
gagagtatga cgaaacaatc cggagcagag tgagggagaa ggcaatgctg
2040ctgaccgata ttagcagctt ccggggcctg cctctgtggc tggcctgtta
catcgtgtat 2100gaccgccact cagagagcaa ggaactggtc aaatgggaga
caccagccga catcgatcat 2160ttcctgtcca agtttaaaca gaacagcctg
cggaacccca tcgtggaaca ggtcattaca 2220gagtccctgc gcactgtgcg
agacatttgg aagcaggagg gaaaaatcga tgagattcac 2280gtggaactgg
gccgggagat gaagaaccct gcaaaagagc gcgcccgaat tacagctcag
2340gtgcaggaaa atgagaacac taatctgaga atcaaggctc tgctggcaga
gttcatgaac 2400cccgaatttg agattgaaaa tgtgcatcca tactcacccg
gccagcagga aatcctgcgg 2460atctacgagg acggcgtgct gagcgggatc
gctgagaagg atctgcctga cgatatcaca 2520gcaattctga agaaattccg
agaaaacgac gtgaagaaac ggccaacaac tagcgaagtc 2580ctgcggtaca
aactgtggct ggagcagcgg tacagatccc catataccgg aagagtgatc
2640cccctgggca agctgttcac acctgcttac gagatcgaac acgtgattcc
ccagagccgg 2700tattttgacg attccatctc taacaaagtg atctgcgaaa
gtgccgtcaa taagctgaaa 2760gataactgtc tgggctatga gttcatcaag
aaacattccg gggagatggt ggaactgggg 2820aatggagaga cagtgcccgt
gttcagcgtg gaagagtacg aacggttcgt caaggagtct 2880tacttcggca
acagtaagaa aatgaagaaa ctgctgctgg aggacatccc agatagcttc
2940attgagagac agctgaatga cagtcgatac atctcacggg tggtcacatc
tctgctgagt 3000aacctggtgt gcgaagaggg agagcaggat ggcctgtcca
agaatgtgat cgtctgtacc 3060ggcgggatta cagacaggct gaagaaagat
tggggagtgc aggaagtctg gaaccgcatc 3120attctgcctc ggttcctgag
actgaatgag atcaccggac ggacagactt tacaagtact 3180tcagtgaacg
gccacctgct gcctgccctg ccactgtacc tgcagaaggg ctttaataag
3240aaaagaattg accataggca ccatgccatg gatgctatcg tgattgcctg
cgctaaccgg 3300aatatcgtca actacctgaa caattcctct gctagaaaga
acagcgaaat tagccgatat 3360gacctgcagc ggctgctgtg tgagaaggtg
aaaaccgatg ccaacggcaa ttacaagtgg 3420atcctgagga aaccatggga
gacattcacc caggatgtgt atgccgctct gacaaacatc 3480gtggtcagct
ttaagcagaa tctgcgcgtg attaatcgaa ccacaaacta ctatcagcac
3540tacaacgagg caggggaaaa gcgcatgatc cctcagacca aaggcgacag
atgggccatt 3600agaaagccaa tgcataaaga tactgtgtat ggcgaagtca
atctgagaaa ggagaaaacc 3660ctgccactga gggacgtggt caagaacccc
agtatcgtgg tcgataaatc actgaagaac 3720aagctgtacg agctgctgaa
gagccagtat gacctgaagg caatcgccaa atacttcgag 3780acacaccagg
acgtgtgggc agatgtcaac ctgaagaaaa ttaaggtgta ctacttcact
3840aaggagacaa acgaaagatt ctttgccact aggaagagcc tggacccatc
ctttgatcag 3900aagaaaatcg aagaggaagt gactgatacc ggcgtccaga
agattctgct gcaccatctg 3960cagcagaaca ataacgaccc tgatatggcc
ttttccccag acggcatcga taggatgaac 4020cagaatatga ccattctgaa
tgacgggaag tggcaccagc ccatctacaa agtgcgcaca 4080tatgaaaagg
cagataaatt cgccgtcggc gagtctggga acaaggccaa gaaatttgtg
4140gaagcagcca aaggcaccaa tctgttcttt gccgtgtacg agagtgtcca
ggaggacgaa 4200gctatcggga agcaggtctg caaacggaca ttcgccacta
tccccctgaa cgaagtgatc 4260aagagaaaga aacagggcct gcccgctgca
cctgaggacc tgaacgggaa tctgcccaag 4320tttgtgctga gccctaacga
tctggtctac ctgcccaccg aggaagagag gaatagttca 4380cgcatcattc
agcctctgga cagggagcgc atctataaga tggtgagctc ctctgggagt
4440cagtgcttct ttatcaaagt gttcgtcgcc aattcaattt gggataagaa
cgaatacagc 4500agcctgaaca agatggagag ggctattaca aacgaaatga
tcaaggagat ttgtgtgcct 4560atcaaaattg accgcctggg caatgtcagc
ctgatccaga tttaagaatt c 46111284458DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
128accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtccatgac aaagactatt ctgggactgg atctggggac
taacagcatt 120ggatgggcac tgattaacca ggacttcgat aacaaaaagg
gggagatcct gggcatgggc 180agccggatca ttcctatgac acaggatatt
aaggacgagt tcggaaaagg caactctatc 240agtcagacag ctgagcgaac
tcgactgcgg ggagtccgga gactgatcca cagaactctg 300ctgaggcgcg
agcggctgca tagagtgctg aatatcattg gcttcctgcc agaacactat
360gccaaccaga ttgactttga gaagaggttc ggcaagttca agcctgaatc
tgagccaaaa 420atcagtttcg atggaaatga cgtgttcctg tttgagaaga
gctaccagga aatgctggtc 480gactttaaaa tccaccagcc acagctggtg
agcaacggca agaaaattcc ccatgactgg 540acaatctact atctgagaaa
gaaagctctg tctaagaaaa ttgagaagga ggaactggca 600tggatcctgc
tgaacttcaa tcagaaacgg ggatactatc agctgagagg cgaggaagag
660gaagagacac caaataagct ggtggagttt catagcctga aaattgtgga
ggtcaacgcc 720gatgaacccc agaaaggaaa gcctgagatc tggtactcac
tggtgctgga aaacggctgg 780gtctatcgac gggctagcaa gactcccctg
ttcgattgga aagacaagat tagggagttt 840atcgtgacca cagaaatcaa
caatgatgga actgtcaaaa ccgacaagga gggcaccgaa 900aagaggagct
tccgcgcacc aaaacccgag gactggactc tgcagaagaa aaagaccgag
960ttcgagctgt caaagagcgg gaatgaagtg ggagccttca tctacgaaag
tatcctgcag 1020aaacccaacc agaagattag aggcaaactg atttcaacca
tcgagaggaa attttataag 1080gaagagctga aaaccatcct gaaaacacag
ctgttctttc acaaagaact gaaggatgag 1140aaactgtaca atgcctgcat
cgaagagctg tataagaaca atgaagctca ccggagcctg 1200ctgtccaaca
aggggttcga gcatctgttt attaacgaca tcctgttcta ccagcgacct
1260ctgcggtcta aaaagagtca gatctcaaac tgcccactgg agaagcgcac
atataaaaag 1320gaggggattg aaatcactga gggcatcaaa gtgatctcca
aatctaatcc aatctaccag 1380gagttccggc tgtggcagtg gattagcaac
ctgtccctgt attgtatcga acccaccgag 1440acaaatgtga cttcaacctt
tctgaacagc attgaagatt acgagaatct gttcgaattt 1500ctgaacaatc
gcaaggaaat cgagcagaag cacctgctga aatatctgct ggagaaccag
1560gggtttaaag gaaagctgct gacaaacgaa ctggagaagt tccgctggaa
ttttgtcgct 1620gacaaaaagt acccctgtaa tgagacaggc agcctgctgc
atactcggct gagcaaagtg 1680aagaacattt cccctgattt cctgaccaag
gaaatcgagc accagctgtg gcatatcatc 1740tacagcgtga ccgacaagat
tgaatatgag caggccctga aaacctttgc tcggaaaaac 1800aatctggatg
tggactcctt ctttgagcac ttcaaaaaga tccccccttt tgagtctacc
1860tacggagcat atagtgaaaa ggccatcaag aagctgctgc cactgatcag
actgggcaaa 1920tactggaact gggaggccat tgatagtatc tcaaaggaca
ggattagtaa aatcctgtca 1980ggggaatacg atgagaacat taagaacaga
gtgagggaga aagcagtcca cctgacctcc 2040gaaaacaatt tccagggact
gcaggagtgg ctggccaagt acatcgtcta tgatcgccat 2100tctgagggca
atgacctggg gaagtggact agcgtgtccg acctggagac atacctgaag
2160gagttcaagc agcatagcct gcggaaccct attgtggagc aggtcatcac
agaaactctg 2220agagtggtca aggatatttg gatcaagcac gggaaaggaa
ccgaaaattt ctttgacgaa 2280atccatgtgg agctgggccg ggaaatgaag
aacaattccg aggatcgcaa acgactgacc 2340aacacaatta ctgaaaacga
gaatacaaac ctgagaatca aggccctgct gatggaaatg 2400atgaatgata
acgacgtgga gaacgtcagg ccttactctc caagtcagca ggagattctg
2460aagatctatg aggacggagc tctgaatagc aacatcgagc tggacgatga
aattgtgaag 2520atctccaaaa aggcagagcc caccaaatct gaactgcagc
gctacaagct gtggctggag 2580cagaaatacc gatcccctta tactggccag
gtcatcccac tgaacaagct gttcacctct 2640gaatatgaga tcgaacacgt
ggtccctcag agtcgcttct ttgacgatag cttcagcaac 2700aaagtgatct
gcgagtcagc cgtcaacaag cggaaggata accagctggg gctgcagttc
2760atcaagaacc atagcggaga aaaagtggag ctgggcttcg ggaaggtggt
ccaggtcttt 2820acagaagagc agtacctgga ttttgtgaag gagcactata
gcaaaaatcg ctccaagcat 2880aacaaactgc tgctggaaga gattcccgag
aagatgatcg aaaggcagct gaatgacact 2940cgctacatca gtaagttcgt
gagctccatt ctgtccaaca tcgtcagatc tgagaaggac 3000gatgacggcc
tgaatagcaa aaacattctg cctggaaatg gcaagatcac taccgaactg
3060aaaagggact gggggctgaa tgatgtgtgg aacgacctga ttctgccaag
attcgagagg 3120atgaatacca tcacaaacag cgatctgttt acaacttaca
acgacaagta tcagaaacac 3180ctgcccaccg tgcctttcga gtactccaag
ggctttcaga aaaagcgcat tgatcaccga 3240caccatgcta tggacgcact
ggtcatcgca tgtgccacac gggatcatct gaatctgatg 3300aacaatcagt
ctgccaagag tgaactgaaa cgatacgacc tgcagaacaa gctgcggaaa
3360aaggagcctt acttcaacca gaaggagaac aaacagaagg aagccttcaa
ggattttatc 3420aaaccatggg gcactttcac cgaggacagc aagaatgctc
tggaaaaaat cattatctcc 3480tttaagcaga acctgagagt gatcaacaag
gcaacaaact catacgagag ctataaggat 3540gaggacggga atctgaggat
cggcaaggat gggaaaccag agaagggcct gatcaagcag 3600aaggggctga
actgggcaat cagaaagccc ctgcacaaag acaccgtgtc aggccagatt
3660aacctgagca ggatcaagct gcccaatggg aaaatcctga cagccactcg
caagaatctg 3720gataccagtt tcgacctgaa aacaattgag aactcaatca
ccgacacagg cattcagaaa 3780atcctgaaga attacctgct gtccaaggaa
tctccagagc tggccttctc tcccgagggc 3840ctggaagaga tgaacaatga
gatcgaaaag tacaacaatg ggaaatttca ccatcctatt 3900aacaaggcta
ggatctatga actggggagc aaattcaatg tcggacagac aggcaacaga
3960agggataagt ttgtggaggc cgctaaagga actaatctgt tctttgctat
ctaccaggac 4020gagaataaga accgctctta tgaaactatt cccctgaacg
aagtgatcga gcaccagaag 4080tggcgagcaa gtctgcctaa ggaagagcag
gagaaaattc cactggtgcc cgtcaacaag 4140ctgaagggga ccttcatctt
ttccctgtct cccaacgatc tggtgtacgt cccttccaat 4200gacgagctgg
aacgaagtgc ttcaattgac ttctctaagc tgaaaaagga acagatcaac
4260cggctgtata aaatggtgtc tagttcagga tcccagtgct tctttgtgaa
gagtgaggtc 4320gcaacctcag tggtcaacaa aatggaatac agcagcctga
acaagatgga gaagtctatc 4380gataacctga tggtgaagga gatttgtatc
aaactgaaga ttgacaggct gggcaacatc 4440agcaaggcct aagaattc
44581294689DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 129accggtgcca ccatgtaccc atacgatgtt
ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag cgtccatgac caaaatcctg
gggctggacc tggggactaa tagcatcggg 120tgggcaatcc gcgacacaga
aaatgagggc atcaatcaga tcctggacaa gggcgcccgc 180attttcagcg
agggagtgaa gtccgagaat ggcaaagaaa tcagtagggc agctgaacga
240accgcttacc ggagcgcaag aaagatcaaa tatcggagaa aactgcggaa
gtacgagaca 300ctgaaggtgc tgtcaattaa cggaatgtgc cccctgagcg
tggaggaagt cgaacagtgg 360aagaaatctg gcttcaagga atatcccctg
aatcctgagt ttctggattg gctgcggacc 420aacgaggaca agaacatcaa
tccttacctg ttcagagata aagctagcaa gcagaaagtg 480acactgtttg
aactgggaag agctctgtat cacatcgcac agaggcgcgg cttcctgagt
540aacaggctgg accagtcagc cgagggcgtc tttgaggaac ataatcctca
gatccagaac 600ctgattgagg acctggacag ctccaacaca attctgaatg
agctgaagga atactatatc 660aatctgggga tcattgacga gactgaaaag
tccggcttca agaaagacct ggatgagggg 720gaaaagaaac tgaagtcact
gtacaacagc ctggtggcca tcacaaagaa aaacgctaac 780gatatcgaaa
cttgcaagca ggagctgatc gctagactga ataagaaaga ggacctgggc
840aaggtcaaag ggaagatcaa agatatttct caggcaatgc tggacaggaa
ctttaagact 900ctgggacagt atttcttttc actgtacaac aaggagcgaa
tccggaacca gtataccagc 960cgcgaggaac actacctgga ggagttcatc
attatctgtc agacccaggg gatcgaggga 1020attaacacaa atgagaagct
gcctgagaag aagttcaccg gcctggcaaa agatctgtat 1080cgagccattt
tctttcagcg gccactgaaa tcccagaagg gcctgatcgg gaagtgctct
1140ttcgagaaga acaagtctcg ctgtgccgtg agtcacccag actatgagga
atttcgaatg 1200tggagctacc tgaacacaat caaaattggc actcagtccg
agaaaaccct gcgcttcctg 1260acactggagg aaaagctgaa actggtgccc
aagttctacc gaaagagtga tttcaacttc 1320gaggtgctgg ctaaggagct
ggtcgaaaaa ggagcatcat tcggctacta caagtctagt 1380aagaaaaatg
agttctttta ctggttcaac tataagccca ccgattcagt gagcgcctgc
1440gtggtgagcg cttctctgga gaacgcaatc ggcaaggact ggaagatcaa
gactttcgaa 1500tatcagacta gaaacaccga gaagaatgaa gtgaccaaat
ccgtcgatta caaggacctg 1560tggcacctgc tgtccgtggc aacatctgat
acttacctgt atgactttgc catcgaaaag 1620ctgaaactgg agcctaaaaa
cgcaaaggcc ttcagcaaga caaaactgaa gaaagacttt 1680gccagtctgt
cactggcagc catcgctaaa attctgccat atctgaagca gggcctgctg
1740tactcccacg ccgtgttcat ggctaacatc gagaatattg tcgacgccga
tatctggaag 1800gatgaggaac agcagaagtt catccagtcc aagattgtgg
agctggtcga caattatatc 1860gtggaaaagt ctaaactgga gctgatcaat
gggctgctga agatctacaa caccgaggat 1920aaggaaggac ggaaagtgta
ctattcaaag gaggctgaaa gcctgttcga ggcagacctg 1980agaaagaaac
tggtcccctt ctacaaggct aacatcatca tcgaggaaca cgagcaggaa
2040atcattttcc aggatctgtt tcctatcctg atggaccagc tgaagaaaca
ggagttcatc 2100aaaattggca gactggataa gcagattgaa gccttcctgg
agggggaaaa tgaggaagga 2160cagatctttt gtaaccacac agataagctg
aagaaactgt accatccaag cgacatcgag 2220gtgtttaaga aaaagactat
caaagatgag tgggggaatg aaaaggtggt cctgggatcc 2280ccactgacca
catctatcaa gaaccccatg gcaatgagag ccctgcacca gctgaggaag
2340gtgctgaata cactgattgc caacgaccag atcgacgagg atactcggat
ccatattgag 2400atggccagag aactgaacga tgctaataag cgaaaaggca
tccaggactt ccagaacgag 2460aacaagaagt ttcgggagga agccatcaag
gagatcaaga agctgtacct ggaggaatgc 2520cacaaagacg tgaaccccac
cgaggacgat atcctgaggt atcagctgtg gctggaacag 2580ggaaagtgcg
agatctacga ggaaggcaac aatatcagca tttgtgatat cattggcagc
2640aatccctcct atgacatcga gcataccatt cctcggagca tctcccagga
taacagccag 2700atgaacaaga cactgtgtag cctgaagttc aacagatcca
tcaaaaagca gaagatgcca 2760gtggagctgt ccaactacaa tgacattctg
cccaggatcg cacactggaa aaaggaggcc 2820gaggaactga ctaggcagat
cgaaaccatt tctcgcagca tcaagagcgc tgcaaccaag 2880gtggccaagg
ataagaacat cagaaagagg cattacctga cactgaagcg agactatatt
2940ctggggaaat acgagcggtt cacttgggag gaacctaaag tgggctttaa
aaactcccag 3000atcccagaca ctgggatcat taccaagtac gctcaggcat
atctgaaatc ttacttcaaa 3060agggtggaga gtgtcaaggg aggagcagtg
gctgagttcc ggaaactgtg gggcatccag 3120gaatctttta tcgatgagaa
ctggtggaag cactataagg acaaagatag agacaaacat 3180acccaccata
caatcgacgc aatcactatt
gcctgtatgc ccaaggataa atacgacctg 3240ctggcacacg cctggaggct
ggaggatgaa caggacaaaa aggccgctaa ggtgctgatc 3300gagcaggcca
aaccatggaa aaccttcaag gaggatatcg aaaagattga gactgaaatc
3360ctggtgagcc attttacccc cgacaacgtc aaaaagcagt caaagagcat
catcaagaat 3420cgcggcaaaa aggtgtacgt cctgaagaac gagctgcctg
tgaacttcaa gaacaagatc 3480gaagggaagg attatttcaa gctgaaattt
gacagcaaga ttctgtacaa aatccccaaa 3540aagaaagaga agcagaccga
tacattctat gaggaactgc ctaaaaacta cctgaatgga 3600gtggaaggca
aggactactt caaaatcaat actaccggca agaccttcta caaaatccca
3660atttttaacc agggcgacac aatccggggg agcctgcacc aggagacaac
ttacggagcc 3720attaagctgc cagatatcga cattgaaaca aagaaacccc
tgcatactga taagggaggc 3780ttcattctga agaaagacat caaaggcaat
gagattgtgt tctttgtggt ccgcaaggaa 3840atctctaaaa ttagtgagaa
cgatgtgcag aatatcgtcg acaacgtggt ccggaagaaa 3900attgagaatg
ctatcgcaaa ctccctgatc acttttaaga tcgtgaagaa aaagaaagtg
3960gccgtcatca aagagggggt caccatttgg atgagggagc ccaacattga
aaaggggatc 4020gagggaatcc ctattaagaa agtgcgcatc attaccaatt
ctgtcaaaaa ccctatcgag 4080attaaggtgc acagtccact gtccaagtct
cgccacaagc ataaacagaa ggtctacggc 4140cagaacgatg agaattatgc
catggctctg tacgaactgg acgggaagcg ggagttcgaa 4200ctgatcaaca
attttaatct ggccaagctg ctgaaacaga gtcagtcata ctatccactg
4260cataaagaga aggaaatcaa gggaaagaaa attctggtgc ccatcgagaa
gagaaacaac 4320aaggatgtca tcctgaagag gggccagcag gtggtgttct
acgacaaaac cgtggagaac 4380cccaaggata tctctgaaat cattgacttt
cgcgagcgaa tctacatcat tgaagggctg 4440accatccaga gacagaaaga
taagaaaaca tccaaagtga atgagtacgg aatcattcag 4500ctgcgccact
tcaaggaagc tcgaaaaagt gaggaaatct caaaggataa cttcaaacct
4560gacggcgagt tcaagatcaa cgagaataag ccaactagga aaatgaacca
taatcagttc 4620accgcctttg tggaggggat cgacttcaag gtcctgccta
gcggaaagtt tcagaaaatt 4680taagaattc 46891303621DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
130accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtccatgag caagaaagtc agtagacgct atgaagaaca
ggcacaggag 120atttgtcaga ggctggggag tagaccttat tccatcgggc
tggacctggg agtgggatct 180atcggagtgg cagtcgccgc ttacgaccca
attaagaaac agccctccga tctggtgttc 240gtcagctcca ggatttttat
cccttctacc ggcgcagccg agcggagaca gaagagagga 300cagaggaaca
gcctgcgcca ccgagcaaat cgcctgaaat tcctgtggaa gctgctggct
360gaacgaaacc tgatgctgtc atatagcgag caggacgtgc cagatcctgc
acggctgaga 420tttgaggacg ctgtggtccg agcaaaccca tacgagctgc
ggctgaaggg cctgaatgaa 480cagctgaccc tgagcgagct ggggtatgca
ctgtaccaca tcgccaatca taggggatct 540agttcagtgc gcacattcct
ggatgaggaa aagagctccg acgataagaa actggaggaa 600cagcaggcta
tgacagaaca gctggcaaaa gagaagggaa tttccacttt catcgaagtg
660ctgacagcct ttaacactaa tggcctgatc gggtacagga actccgagtc
tgtgaagagt 720aagggcgtgc cagtccccac tcgcgacatc atttcaaatg
agattgatgt gctgctgcag 780acccagaagc agttctatca ggaaatcctg
tcagacgagt actgcgatcg gattgtcagc 840gcaatcctgt ttgaaaacga
gaagatcgtg ccagaagccg gctgctgtcc ctatttccct 900gacgagaaga
aactgcccag atgtcacttt ctgaatgagg aaaggcgcct gtgggaagcc
960attaacaatg ctaggatcaa gatgcccatg caggagggcg ctgcaaaacg
ctaccagagt 1020gcttcattca gcgacgagca gagacacatt ctgtttcata
tcgcaaggag cgggactgat 1080atcaccccta aactggtgca gaaggagttc
ccagccctga aaacctccat cattgtgctg 1140cagggaaaag agaaggctat
tcagaagatc gcaggcttcc gatttcgacg gctggaggaa 1200aaatcttttt
ggaagagact gagtgaggaa cagaaggacg atttctttag cgcctggaca
1260aacactcctg acgataaaag actgtccaag tacctgatga aacacctgct
gctgacagaa 1320aatgaggtgg tcgacgccct gaaaaccgtg agcctgattg
gagattatgg cccaatcggc 1380aagaccgcaa cacagctgct gatgaaacat
ctggaggatg gcctgactta caccgaagcc 1440ctggagcggg gaatggaaac
cggcgagttc caggaactgt cagtgtggga gcagcagagc 1500ctgctgccct
actatgggca gatcctgaca ggatctactc aggccctgat ggggaagtat
1560tggcactctg cttttaaaga aaagagagac agtgagggat tctttaagcc
taacacaaat 1620agcgatgagg aaaaatacgg caggattgcc aacccagtgg
tccatcagac tctgaacgaa 1680ctgcgcaagc tgatgaatga gctgattacc
atcctgggag ctaaacctca ggagatcaca 1740gtggaactgg cacgagagct
gaaggtcgga gctgagaaaa gagaggacat cattaagcag 1800cagaccaaac
aggaaaagga ggctgtgctg gcatatagca agtactgcga gcccaacaat
1860ctggacaaaa ggtatattga aaggttccgc ctgctggagg atcaggcctt
tgtgtgccct 1920tactgtctgg agcacattag cgtcgcagat atcgcagctg
gaagggcaga cgtggatcat 1980atcttcccac gcgacgatac agctgacaac
tcctacggga ataaggtggt cgcacaccga 2040cagtgtaacg atatcaaggg
aaagcggacc ccctatgcag ccttcagtaa tacatcagcc 2100tggggcccca
tcatgcatta cctggacgaa acccctggga tgtggcgcaa aagaaggaag
2160tttgagacaa acgaggaaga gtatgctaag tacctgcagt caaaaggctt
cgtgagcagg 2220tttgaaagcg ataactccta tatcgcaaaa gctgcaaagg
agtacctgcg ctgcctgttc 2280aatccaaaca atgtgactgc cgtcgggtcc
ctgaagggaa tggagacatc tatcctgcgg 2340aaggcctgga atctgcaggg
aattgacgat ctgctgggca gccggcactg gagtaaggac 2400gccgatacca
gccccacaat gcgcaaaaac cgggacgaca atcggcacca tggcctggac
2460gccatcgtgg ctctgtattg ttccagatct ctggtccaga tgattaacac
catgtccgag 2520cagggcaagc gagcagtgga aatcgaggct atgattccta
tcccagggta cgcatccgaa 2580ccaaatctgt ctttcgaagc ccagcgggag
ctgtttagaa agaaaatcct ggagttcatg 2640gacctgcacg cctttgtgag
tatgaaaacc gacaacgatg caaatggcgc cctgctgaaa 2700gatactgtgt
attcaattct gggagcagac acccagggag aggatctggt gttcgtggtc
2760aagaaaaaga ttaaggacat cggcgtgaaa atcggggatt atgaagaggt
cgcatctgcc 2820attcgaggcc ggatcaccga caaacagcca aagtggtatc
ccatggaaat gaaagataag 2880atcgagcagc tgcagtctaa gaacgaagcc
gctctgcaga aatacaagga gagtctggtg 2940caggcagccg ctgtcctgga
agagagtaat aggaagctga ttgagtcagg caaaaagccc 3000atccagctga
gtgaaaaaac aatttcaaaa aaggccctgg agctggtggg cgggtactat
3060tacctgatta gcaacaacaa gcgcacaaag actttcgtgg tcaaggaacc
ttcaaacgag 3120gtgaaagggt tcgcatttga cactggaagc aatctgtgcc
tggactttta tcacgatgcc 3180cagggaaagc tgtgtggcga gatcattaga
aaaatccagg ctatgaaccc ttcctataag 3240ccagcataca tgaaacaggg
gtattctctg tacgtgagac tgtaccaggg cgacgtgtgc 3300gagctgaggg
caagcgatct gactgaagca gagtccaacc tggccaagac cacacatgtc
3360cgcctgccca atgctaaacc tgggcgaacc ttcgtgatca ttatcacctt
tacagagatg 3420gggtctggat atcagatcta cttcagcaac ctggccaagt
ccaaaaaggg acaggacact 3480agttttaccc tgactaccat caagaattat
gatgtgcgga aagtccagct gtctagtgcc 3540gggctggtga gatacgtcag
ccctctgctg gtggacaaaa tcgagaagga tgaagtcgct 3600ctgtgtggag
agtaagaatt c 36211313588DNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotide 131accggtgcca
ccatgtaccc atacgatgtt ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag
cgtccatggc aagacctgca tttcgggcac ctcggagaga acacgtcaac
120ggctggaccc ctgacccaca tcggattagc aaaccctttt tcatcctggt
gagctggcac 180ctgctgtccc gggtggtcat tgacagctcc tctggatgct
tcccaggcac cagccgggac 240cacaccgaca agtttgccga gtgggaatgt
gctgtgcagc cctacaggct gagtttcgac 300ctggggacca actcaatcgg
atggggcctg ctgaatctgg atcgccaggg aaaaccaagg 360gagatccgag
cactggggtc ccgcatcttc agcgacggac gggatcccca ggacaaggct
420tctctggctg tggcacggag actggccaga cagatgaggc gccgacggga
cagatatctg 480actagaagga ccaggctgat gggagctctg gtgcgcttcg
gcctgatgcc agcagaccct 540gcagctagga agcgcctgga agtggccgtc
gatccatacc tggcacgaga gcgggccaca 600agagaaaggc tggagccctt
cgaaatcggg agggccctgt ttcacctgaa ccagcgccga 660ggatataaac
ccgtgcgcac cgccacaaag cctgatgagg aagccggcaa ggtgaaagag
720gctgtcgaaa ggctggaggc agcaatcgct gcagccggag cacctactct
gggagcttgg 780ttcgcatggc gaaaaacacg aggagaaact ctgcgagcac
gactggctgg gaagggaaaa 840gaggctgcat acccattcta tcccgcacgg
agaatgctgg aggccgaatt tgacactctg 900tgggcagagc aggccaggca
ccatccagat ctgctgaccg ccgaagctcg cgagatcctg 960cggcacagaa
tttttcatca gcggcccctg aagccacctc cagtgggaag atgcactctg
1020taccctgacg atgggagagc tcctagggca ctgccaagcg ctcagaggct
gcgcctgttc 1080caggagctgg ccagcctgag agtgatccac ctggacctgt
ccgaacgccc tctgacccca 1140gctgagcgag atcggattgt ggcatttgtc
cagggcagac cccctaaagc cggaaggaag 1200cctggcaaag tgcagaagag
cgtcccattc gaaaagctga gggggctgct ggagctgcca 1260ccaggcactg
ggttttctct ggagagtgac aaacggcctg aactgctggg cgacgagaca
1320ggcgccagaa tcgcaccagc attcggacct ggatggacag ctctgcctct
ggaggaacag 1380gacgccctgg tggaactgct gctgacagag gcagaaccag
agagggcaat tgcagctctg 1440actgcacgat gggctctgga cgaggcaact
gcagcaaagc tggctggagc aaccctgcca 1500gattttcacg gacgatatgg
caggcgcgca gtggctgaac tgctgcctgt cctggaacgc 1560gagacacgag
gcgacccaga tgggagagtg aggcccatcc ggctggacga ggcagtgaaa
1620ctgctgagag gcgggaagga tcactcagac ttcagccggg aaggagctct
gctggacgca 1680ctgccctact atggagccgt gctggagaga catgtcgctt
ttgggacagg aaaccccgca 1740gatcctgagg aaaagcgggt gggaagagtc
gccaatccca ctgtgcacat cgctctgaac 1800cagctgcggc atctggtgaa
tgcaattctg gccaggcacg gccgccctga ggaaatcgtg 1860attgagctgg
cacgggacct gaaaaggtct gccgaagatc gacggagaga ggacaagcgg
1920caggccgata accagaaaag aaatgaggaa cgcaagcgac tgatcctgag
tctgggagag 1980cgcccaaccc cacgaaacct gctgaagctg cggctgtggg
aggaacaggg cccagtggaa 2040aataggcgct gcccctactc tggggagaca
attagtatga gaatgctgct gagcgagcag 2100gtggacatcg atcacattct
gccattcagc gtgtccctgg acgattccgc tgcaaacaag 2160gtggtctgtc
tgcgggaggc caacagaatc aagcggaata gatctccctg ggaggccttc
2220ggccatgaca gtgagagatg ggcagggatt ctggcacgag cagaagctct
gcccaagaac 2280aaaaggtggc gctttgctcc tgacgcactg gagaaactgg
aaggagaggg aggcctgcga 2340gcacgacacc tgaatgatac aaggcatctg
agtcgcctgg ccgtggagta tctgcggtgc 2400gtctgtccta aggtgcgggt
gagcccaggc cgactgactg cactgctgcg acggagatgg 2460ggcatcgacg
ccattctggc agaagcagat ggacctccac cagaagtgcc cgcagagaca
2520ctggaccctt ccccagctga gaagaaccga gcagaccacc ggcaccatgc
cctggatgct 2580gtggtcatcg gctgtattga tcgctcaatg gtgcagcgag
tccagctggc cgctgcaagc 2640gcagaaagag aggccgctgc aagggaggac
aatatcaggc gcgtgctgga gggattcaaa 2700gaggaacctt gggatggctt
tagagctgaa ctggagcgac gggcacggac catcgtggtg 2760agccacagac
cagaacatgg gattggggga gccctgcata aggagacagc ttacgggcct
2820gtggaccctc cagaggaagg attcaacctg gtggtcagga aaccaatcga
cggcctgtca 2880aaggatgaga ttaatagcgt gcgggacccc cggctgagaa
gggcactgat cgatcgcctg 2940gccattcgcc gacgggatgc taacgaccct
gctaccgcac tggccaaagc agctgaggat 3000ctggcagcac agccagcctc
ccgcggcatc agaagggtgc gggtcctgaa gaaagaatct 3060aaccccatta
gggtggagca cggcgggaat ccaagtggac cccgctcagg aggccctttt
3120cataagctgc tgctggcagg agaggtgcac catgtggacg tcgcactgcg
agcagatggc 3180cgccgatggg tgggacactg ggtcacactg ttcgaggcac
atgggggacg gggagcagac 3240ggagctgcag ccccacctag actgggcgat
ggggaaagat ttctgatgag gctgcacaag 3300ggagactgcc tgaaactgga
gcataagggc agagtgaggg tcatgcaggt ggtcaaactg 3360gaacctagtt
caaatagcgt ggtcgtggtc gagccacacc aggtgaaaac cgacagatcc
3420aaacatgtca agatctcttg tgatcagctg cgcgctcgag gagcacggag
agtgaccgtc 3480gatccactgg gacgggtgag agtccacgcc ccaggagcta
gggtgggaat cggaggggac 3540gccggacgaa ccgctatgga acccgcagag
gatattagct aagaattc 35881323234DNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotide 132accggtgcca
ccatgtaccc atacgatgtt ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag
cgtccatggg agagaatatg attgacgaga gtctgacctt cggcattgac
120ctggggattg ggagttgtgg gtgggcagtg ctgaggcggc caagcgcctt
cggacggaag 180ggcgtgatcg agggaatggg ctcctggtgc tttgacgtcc
ccgagacatc taaagaacgg 240actcctacca accagatccg gagatccaat
agactgctga ggcgcgtgat ccgacggaga 300aggaaccgga tggccgctat
tcgccgactg ctgcacgcag caggcctgct gccatcaacc 360gacagcgatg
ccctgaagcg gcccggacat gatccttggg aactgagggc acgaggcctg
420gacaagccac tgaaacccgt ggagttcgct gtggtcctgg gccacatcgc
aaagcggaga 480gggtttaaat ccgctgcaaa gagaaaagcc acaaacatta
gctccgacga taagaaaatg 540ctgacagccc tggaggctac tcgagaacgg
ctggggagat acaggaccgt gggagaaatg 600ttcgccaggg accctgattt
tgcttctagg cgccgaaatc gcgagggcaa gtatgatagg 660accacagctc
gcgacgatct ggagcacgaa gtgcacgccc tgttcgcagc tcagcggaga
720ctgggacagg gatttgccag tccagaactg gaggaggcct tcaccgcttc
agcatttcat 780cagaggccca tgcaggacag cgagcgcctg gtgggattct
gcccttttga gcgaaccgaa 840aagcgggcag ccaaactgac accctctttc
gagcgctttc gactgctggc ccggctgctg 900aacctgagaa tcactacccc
agacggagag cggcccctga cagtggatga aattgctctg 960gtcacccggg
acctgggcaa gaccgcaaaa ctgagtatca agcgggtgag aactctgatt
1020ggactggagg acaatcagag gttcacaact atccgccccg aggacgaaga
tcgagacatt 1080gtggctcgga caggcggggc aatgacaggg actgccaccc
tgaggaaggc actgggagag 1140gccctgtgga ctgatatgca ggagcgccct
gaacagctgg acgctatcgt gcaggtcctg 1200agcttctttg aggccaacga
aacaatcact gagaagctga gggaaattgg cctgactctg 1260gccgtgctgg
acgtcctgct gaccgcactg gatgccggag tgttcgccaa gtttaaaggc
1320gctgcacaca tcagcaccaa agccgctagg aatctgctgc cacatctgga
gcagggcagg 1380cgctacgatg aggcctgcac aatggcaggg tatgaccacg
cagcctcccg cctgtctcac 1440catggccaga tcgtggcaaa gacacagttc
aacgccctgg tcactgagat cggcgaatcc 1500attgccaatc caatcgctcg
gaaggcactg atcgaggggc tgaaacagat ttgggccatg 1560agaaaccact
gggggctgcc cggaagtatc catgtggagc tggcccggga tgtcggcaac
1620tcaattgaaa agcgacggga gattgaaaag cacatcgaga aaaatactgc
cctgagggct 1680cgcgagagaa gggaggtgca tgatctgctg gacctggaag
atgtcaatgg cgacaccctg 1740ctgcgatacc ggctgtggaa ggagcaggga
ggcaaatgcc tgtatacagg gaaggccatc 1800cacattcggc agatcgctgc
aactgacaac tccgtgcagg tcgatcatat tctgccttgg 1860agccggttcg
gcgacgatag ttttaacaac aagaccctgt gtctggcctc tgctaatcag
1920cagaagaaaa ggtcaacacc atacgagtgg ctgagcggcc agactgggga
tgcatggaac 1980gccttcgtgc agcgcatcga gacaaataag gaactgagag
ggtttaagaa aaggaactat 2040ctgctgaaga atgctaaaga ggcagaggaa
aaattcagaa gcaggaacct gaatgacacc 2100agatacgccg ctaggctgtt
cgcagaggcc gtgaagctgc tgtatgcctt tggggagaga 2160caggaaaaag
ggggaaaccg ccgagtgttt actcggcctg gagcactgac cgcagcactg
2220agacaggctt ggggagtgga gagcctgaag aaacaggatg ggaagcgcat
caatgacgat 2280cgacaccatg ccctggatgc tctgaccgtg gctgcagtcg
acgaggccga aattcagagg 2340ctgacaaaat cattccacga gtgggaacag
cagggcctgg ggcggcctct gcggagagtg 2400gagccacctt gggagagctt
ccgggcagac gtcgaggcta cctaccctga agtgtttgtc 2460gcacggccag
agaggcgccg agcaagagga gaaggccatg ccgctaccat ccggcaggtg
2520aaggagagag aatgcacacc aattgtgttt gagagaaagg ctgtctctag
tctgaaagag 2580gcagacctgg aacgaatcaa agatggcgag cgcaacgaag
caattgtgga ggccatcagg 2640agctggattg ccactggacg cccagctgat
gcaccaccac gctccccccg aggcgacatc 2700attaccaaga tcaggctggc
caccaccatc aaggcagccg tgcctgtccg cggagggacc 2760gcaggaaggg
gagaaatggt gcgcgcagat gtgttcagca agccaaaccg gagagggaaa
2820gacgagtggt atctggtgcc cgtgtatcca caccagatca tgaacaggaa
ggcttggccc 2880aaacctccaa tgcgctcaat tgtggccaat aaggatgagg
acgaatggac cgaagtggga 2940cctgaacacc agttccggtt tagcctgtac
cctagatcca atatcgagat cattaggcca 3000tctggagaag tgatcgaagg
atatttcgtc ggcctgcatc gcaacactgg cgctctgacc 3060atcagtgcac
acaatgatcc caagagtatc cattcaggca ttgggaccaa gacactgctg
3120gccatttcca aataccaggt ggacagattc ggcagaaagt ctccagtgcg
caaagaggtc 3180cgaacttggc acggggaagc ctgtatctct cccacccccc
ctggataaga attc 32341333504DNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotide 133accggtgcca
ccatgtaccc atacgatgtt ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag
cgtccatgag agagaacggg agtgacgaaa ggcggaggaa tatggacgaa
120aaaatggatt acaggattgg gctggacatc ggcatcgcat cagtggggtg
ggccgtcctg 180cagaacaatt cagacgatga gcctgtgagg attgtcgacc
tgggagtgcg cattttcgat 240accgcagaga tcccaaagac aggcgaaagc
ctggcaggac cccggagagc agctcgaacc 300acaaggcgcc gactgcggag
aaggaaacac cgcctggacc gaatcaagtg gctgttcgag 360aaccaggggc
tgatcaatat tgacgatttt ctgaagagat acaacatggc cggactgcca
420gatgtgtacc agctgcggta tgaggctctg gacagaaaac tgaccgatga
ggaactggcc 480caggtgctgc tgcacatcgc taagcatcgg ggcttcagaa
gcaccaggaa agccgagaca 540gcagccaagg aaaacggggc agtgctgaag
gccacagacg agaatcagaa acgaatgcag 600gaaaagggat acaggacagt
gggcgagatg atctacctgg acgaggcctt ccggactggc 660tgctcttgga
gtgagaaagg gtacatcctg accccccgca acaaggctga aaattatcag
720cacacaatgc tgcgggcaat gctggtggag gaagtcaagg agattttcag
ctcccagcgc 780cgactgggca acgaaaaagc cactgaggaa ctggaggaaa
agtacctgga gatcatgacc 840tcccagcgct cttttgacct ggggcctgga
atgcagccag atgggaagcc ctccccttat 900gcaatggagg gcttctctga
cagagtgggg aaatgtactt ttctggggga tcagggagag 960ctgaggggcg
ctaaggggac ctacacagcc gaatatttcg tggctctgca gaaaatcaac
1020cacacaaagc tggtcaatca ggacggcgag acaaggaatt tcactgagga
agagcggaga 1080gccctgactc tgctgctgtt tacccagaaa gaggtgaagt
acgctgcagt ccgcaagaaa 1140ctgggcctgc ctgaggacat cctgttctac
aacctgaact acaagaaggc cgctactaaa 1200gaagagcagc agaaggagaa
ccagaatacc gaaaaagcca agtttatcgg gatgccatac 1260tatcacgatt
acaagaaatg cctggaagag agagtgaagt atctgaccga gaacgaagtc
1320agggacctgt ttgatgagat cggaatgatt ctgacttgtt acaaaaatga
cgattcccgc 1380accgaacgac tggccaagct gggactggtg cccatcgaga
tggaaggcct gctggcttat 1440actcctacca aattccagca tctgtctatg
aaggcaatgc ggaacatcat tccctttctg 1500gagaaaggga tgacctacga
caaggcttgc gaagaggcag gatatgactt caaagccgat 1560agcaagggga
ctaaacagaa gctgctgacc ggagagaacg tgaatcagac aatcaacgaa
1620attactaatc ctgtggtcaa acgctcagtg agccagacag tgaaggtcat
taacgccatc 1680attcggactt acggcagtcc acaggctatc aatattgagc
tggcaagaga aatgtcaaag 1740acctttgaag agaggcgcaa aatcaagggg
gacatggaga aacggcagaa gaacaatgaa 1800gatgtgaaga aacagattca
ggagctggga aaactgtctc ctacaggcca ggacatcctg 1860aagtacagac
tgtggcagga gcagcagggg atttgtatgt atagtggaaa aaccatccca
1920ctggaagagc tgttcaagcc cggctacgac atcgatcaca ttctgcccta
ttcaattaca 1980ttcgacgata gctttaggaa caaagtgctg gtcacatccc
aggagaacag acagaagggc 2040aataggactc cttacgagta tatggggaac
gacgaacagc gctggaatga gtttgaaacc 2100agggtgaaaa ctaccatccg
cgattacaag aaacagcaga agctgctgaa gaaacatttc 2160tctgaagagg
aaaggagtga gtttaaagaa cggaacctga cagacactaa gtacatcaca
2220accgtgatct acaacatgat cagacagaat ctggagatgg cccccctgaa
ccgccctgaa 2280aagaaaaagc aggtgcgggc tgtcaatggc gcaattaccg
cctacctgcg aaaacggtgg 2340gggctgccac agaagaatcg ggagacagac
acacaccatg ctatggatgc agtggtcatc 2400gcctgctgta ccgacggcat
gatccagaaa attagtagat acacaaaggt gagagagagg 2460tgctattcaa
agggaacaga gttcgtcgat gcagagactg gcgaaatctt tagacccgag
2520gactacagca gggccgagtg ggatgaaatt ttcggcgtgc acatcccaaa
gccctgggag 2580acatttcgcg ccgaactgga cgtccgaatg ggggacgatc
caaagggatt cctggacact 2640catagcgatg tggctctgga gctggattat
cccgagtaca tctacgaaaa cctgcggcct 2700atcttcgtga gcagaatgcc
aaatcacaag gtcaccggag cagcccatgc tgacacaatt 2760cggtccccaa
gacactttaa agatgagggc atcgtgctga ctaagaccgc actgaccgac
2820ctgaaactgg acaaggatgg ggagatcgac ggatactata acccccagtc
cgatctgctg 2880ctgtacgaag cactgaaaaa gcagctgctg ctgtatggca
atgatgccaa aaaggccttc 2940gctcaggact ttcataaacc caaggccgat
ggaactgagg gccctgtggt caggaaggtg 3000aagatccaga aaaagcagac
catgggagtg ttcgtcgact ctggcaacgg gattgccgag 3060aatggcggga
tggtgcgcat cgatgtgttc cgagtcaacg gcaagtacta ttttgtgccc
3120gtctacaccg ctgacgtggt caaaaaggtg ctgcctaata gggccagtac
agctcacaag 3180ccatacggcg agtggaaagt gatggaggac aaggatttcc
tgtttagtct gtattcacgc 3240gacctgatcc atatcaagtc taaaaaggat
atccctatta agatggtgaa cggaggcatg 3300gaggggatca aggaaaccta
cgcatactat attggagccg acatcagcgc tgcaaatatc 3360cagggcattg
cccacgattc caggtataaa ttccgcggac tgggcattca gtctctggac
3420gtgctggaga agtgtcagat cgatgtgctg ggacatgtca gcgtggtccg
atccgaaaag 3480cggatgggct ttagctaaga attc 35041343243DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
134accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtccatgaa aaggaactac attctggggc tggacatcgg
gattacaagc 120gtggggtatg ggattattga ctatgaaaca agggacgtga
tcgacgcagg cgtcagactg 180ttcaaggagg ccaacgtgga aaacaatgag
ggacggagaa gcaagagggg agccaggcgc 240ctgaaacgac ggagaaggca
cagaatccag agggtgaaga aactgctgtt cgattacaac 300ctgctgaccg
accattctga gctgagtgga attaatcctt atgaagccag ggtgaaaggc
360ctgagtcaga agctgtcaga ggaagagttt tccgcagctc tgctgcacct
ggctaagcgc 420cgaggagtgc ataacgtcaa tgaggtggaa gaggacaccg
gcaacgagct gtctacaaag 480gaacagatct cacgcaatag caaagctctg
gaagagaagt atgtcgcaga gctgcagctg 540gaacggctga agaaagatgg
cgaggtgaga gggtcaatta ataggttcaa gacaagcgac 600tacgtcaaag
aagccaagca gctgctgaaa gtgcagaagg cttaccacca gctggatcag
660agcttcatcg atacttatat cgacctgctg gagactcgga gaacctacta
tgagggacca 720ggagaaggga gccccttcgg atggaaagac atcaaggaat
ggtacgagat gctgatggga 780cattgcacct attttccaga agagctgaga
agcgtcaagt acgcttataa cgcagatctg 840tacaacgccc tgaatgacct
gaacaacctg gtcatcacca gggatgaaaa cgagaaactg 900gaatactatg
agaagttcca gatcatcgaa aacgtgttta agcagaagaa aaagcctaca
960ctgaaacaga ttgctaagga gatcctggtc aacgaagagg acatcaaggg
ctaccgggtg 1020acaagcactg gaaaaccaga gttcaccaat ctgaaagtgt
atcacgatat taaggacatc 1080acagcacgga aagaaatcat tgagaacgcc
gaactgctgg atcagattgc taagatcctg 1140actatctacc agagctccga
ggacatccag gaagagctga ctaacctgaa cagcgagctg 1200acccaggaag
agatcgaaca gattagtaat ctgaaggggt acaccggaac acacaacctg
1260tccctgaaag ctatcaatct gattctggat gagctgtggc atacaaacga
caatcagatt 1320gcaatcttta accggctgaa gctggtccca aaaaaggtgg
acctgagtca gcagaaagag 1380atcccaacca cactggtgga cgatttcatt
ctgtcacccg tggtcaagcg gagcttcatc 1440cagagcatca aagtgatcaa
cgccatcatc aagaagtacg gcctgcccaa tgatatcatt 1500atcgagctgg
ctagggagaa gaacagcaag gacgcacaga agatgatcaa tgagatgcag
1560aaacgaaacc ggcagaccaa tgaacgcatt gaagagatta tccgaactac
cgggaaagag 1620aacgcaaagt acctgattga aaaaatcaag ctgcacgata
tgcaggaggg aaagtgtctg 1680tattctctgg aggccatccc cctggaggac
ctgctgaaca atccattcaa ctacgaggtc 1740gatcatatta tccccagaag
cgtgtccttc gacaattcct ttaacaacaa ggtgctggtc 1800aagcaggaag
agaactctaa aaagggcaat aggactcctt tccagtacct gtctagttca
1860gattccaaga tctcttacga aacctttaaa aagcacattc tgaatctggc
caaaggaaag 1920ggccgcatca gcaagaccaa aaaggagtac ctgctggaag
agcgggacat caacagattc 1980tccgtccaga aggattttat taaccggaat
ctggtggaca caagatacgc tactcgcggc 2040ctgatgaatc tgctgcgatc
ctatttccgg gtgaacaatc tggatgtgaa agtcaagtcc 2100atcaacggcg
ggttcacatc ttttctgagg cgcaaatgga agtttaaaaa ggagcgcaac
2160aaagggtaca agcaccatgc cgaagatgct ctgattatcg caaatgccga
cttcatcttt 2220aaggagtgga aaaagctgga caaagccaag aaagtgatgg
agaaccagat gttcgaagag 2280aagcaggccg aatctatgcc cgaaatcgag
acagaacagg agtacaagga gattttcatc 2340actcctcacc agatcaagca
tatcaaggat ttcaaggact acaagtactc tcaccgggtg 2400gataaaaagc
ccaacagaga gctgatcaat gacaccctgt atagtacaag aaaagacgat
2460aaggggaata ccctgattgt gaacaatctg aacggactgt acgacaaaga
taatgacaag 2520ctgaaaaagc tgatcaacaa aagtcccgag aagctgctga
tgtaccacca tgatcctcag 2580acatatcaga aactgaagct gattatggag
cagtacggcg acgagaagaa cccactgtat 2640aagtactatg aagagactgg
gaactacctg accaagtata gcaaaaagga taatggcccc 2700gtgatcaaga
agatcaagta ctatgggaac aagctgaatg cccatctgga catcacagac
2760gattacccta acagtcgcaa caaggtggtc aagctgtcac tgaagccata
cagattcgat 2820gtctatctgg acaacggcgt gtataaattt gtgactgtca
agaatctgga tgtcatcaaa 2880aaggagaact actatgaagt gaatagcaag
tgctacgaag aggctaaaaa gctgaaaaag 2940attagcaacc aggcagagtt
catcgcctcc ttttacaaca acgacctgat taagatcaat 3000ggcgaactgt
atagggtcat cggggtgaac aatgatctgc tgaaccgcat tgaagtgaat
3060atgattgaca tcacttaccg agagtatctg gaaaacatga atgataagcg
cccccctcga 3120attatcaaaa caattgcctc taagactcag agtatcaaaa
agtactcaac cgacattctg 3180ggaaacctgt atgaggtgaa gagcaaaaag
caccctcaga ttatcaaaaa gggctaagaa 3240ttc 32431353243DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
135accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtccatgaa aaggaactac attctggggc tggacatcgg
gattacaagc 120gtggggtatg ggattattga ctatgaaaca agggacgtga
tcgacgcagg cgtcagactg 180ttcaaggagg ccaacgtgga aaacaatgag
ggacggagaa gcaagagggg agccaggcgc 240ctgaaacgac ggagaaggca
cagaatccag agggtgaaga aactgctgtt cgattacaac 300ctgctgaccg
accattctga gctgagtgga attaatcctt atgaagccag ggtgaaaggc
360ctgagtcaga agctgtcaga ggaagagttt tccgcagctc tgctgcacct
ggctaagcgc 420cgaggagtgc ataacgtcaa tgaggtggaa gaggacaccg
gcaacgagct gtctacaaag 480gaacagatct cacgcaatag caaagctctg
gaagagaagt atgtcgcaga gctgcagctg 540gaacggctga agaaagatgg
cgaggtgaga gggtcaatta ataggttcaa gacaagcgac 600tacgtcaaag
aagccaagca gctgctgaaa gtgcagaagg cttaccacca gctggatcag
660agcttcatcg atacttatat cgacctgctg gagactcgga gaacctacta
tgagggacca 720ggagaaggga gccccttcgg atggaaagac atcaaggaat
ggtacgagat gctgatggga 780cattgcacct attttccaga agagctgaga
agcgtcaagt acgcttataa cgcagatctg 840tacaacgccc tgaatgacct
gaacaacctg gtcatcacca gggatgaaaa cgagaaactg 900gaatactatg
agaagttcca gatcatcgaa aacgtgttta agcagaagaa aaagcctaca
960ctgaaacaga ttgctaagga gatcctggtc aacgaagagg acatcaaggg
ctaccgggtg 1020acaagcactg gaaaaccaga gttcaccaat ctgaaagtgt
atcacgatat taaggacatc 1080acagcacgga aagaaatcat tgagaacgcc
gaactgctgg atcagattgc taagatcctg 1140actatctacc agagctccga
ggacatccag gaagagctga ctaacctgaa cagcgagctg 1200acccaggaag
agatcgaaca gattagtaat ctgaaggggt acaccggaac acacaacctg
1260tccctgaaag ctatcaatct gattctggat gagctgtggc atacaaacga
caatcagatt 1320gcaatcttta accggctgaa gctggtccca aaaaaggtgg
acctgagtca gcagaaagag 1380atcccaacca cactggtgga cgatttcatt
ctgtcacccg tggtcaagcg gagcttcatc 1440cagagcatca aagtgatcaa
cgccatcatc aagaagtacg gcctgcccaa tgatatcatt 1500atcgagctgg
ctagggagaa gaacagcaag gacgcacaga agatgatcaa tgagatgcag
1560aaacgaaacc ggcagaccaa tgaacgcatt gaagagatta tccgaactac
cgggaaagag 1620aacgcaaagt acctgattga aaaaatcaag ctgcacgata
tgcaggaggg aaagtgtctg 1680tattctctgg aggccatccc cctggaggac
ctgctgaaca atccattcaa ctacgaggtc 1740gatcatatta tccccagaag
cgtgtccttc gacaattcct ttaacaacaa ggtgctggtc 1800aagcaggaag
agaactctaa aaagggcaat aggactcctt tccagtacct gtctagttca
1860gattccaaga tctcttacga aacctttaaa aagcacattc tgaatctggc
caaaggaaag 1920ggccgcatca gcaagaccaa aaaggagtac ctgctggaag
agcgggacat caacagattc 1980tccgtccaga aggattttat taaccggaat
ctggtggaca caagatacgc tactcgcggc 2040ctgatgaatc tgctgcgatc
ctatttccgg gtgaacaatc tggatgtgaa agtcaagtcc 2100atcaacggcg
ggttcacatc ttttctgagg cgcaaatgga agtttaaaaa ggagcgcaac
2160aaagggtaca agcaccatgc cgaagatgct ctgattatcg caaatgccga
cttcatcttt 2220aaggagtgga aaaagctgga caaagccaag aaagtgatgg
agaaccagat gttcgaagag 2280aagcaggccg aatctatgcc cgaaatcgag
acagaacagg agtacaagga gattttcatc 2340actcctcacc agatcaagca
tatcaaggat ttcaaggact acaagtactc tcaccgggtg 2400gataaaaagc
ccaacagaga gctgatcaat gacaccctgt atagtacaag aaaagacgat
2460aaggggaata ccctgattgt gaacaatctg aacggactgt acgacaaaga
taatgacaag 2520ctgaaaaagc tgatcaacaa aagtcccgag aagctgctga
tgtaccacca tgatcctcag 2580acatatcaga aactgaagct gattatggag
cagtacggcg acgagaagaa cccactgtat 2640aagtactatg aagagactgg
gaactacctg accaagtata gcaaaaagga taatggcccc 2700gtgatcaaga
agatcaagta ctatgggaac aagctgaatg cccatctgga catcacagac
2760gattacccta acagtcgcaa caaggtggtc aagctgtcac tgaagccata
cagattcgat 2820gtctatctgg acaacggcgt gtataaattt gtgactgtca
agaatctgga tgtcatcaaa 2880aaggagaact actatgaagt gaatagcaag
tgctacgaag aggctaaaaa gctgaaaaag 2940attagcaacc aggcagagtt
catcgcctcc ttttacaaca acgacctgat taagatcaat 3000ggcgaactgt
atagggtcat cggggtgaac aatgatctgc tgaaccgcat tgaagtgaat
3060atgattgaca tcacttaccg agagtatctg gaaaacatga atgataagcg
cccccctcga 3120attatcaaaa caattgcctc taagactcag agtatcaaaa
agtactcaac cgacattctg 3180ggaaacctgt atgaggtgaa gagcaaaaag
caccctcaga ttatcaaaaa gggctaagaa 3240ttc 32431363891DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
136accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtccatgaa caatagcatc aaatctaaac ctgaagtgac
catcgggctg 120gacctgggag tgggaagcgt ggggtgggca atcgtggata
acgaaacaaa catcattcac 180catctgggct ccaggctgtt ttctcaggcc
aagactgctg aggatcggag atctttccgc 240ggggtgaggc gcctgatccg
acggagaaaa tacaagctga aacgattcgt caatctgatt 300tggaagtaca
acagctattt cggcttcaag aacaaagagg acatcctgaa caattatcag
360gagcagcaga agctgcacaa taccgtgctg aacctgaaat cagaggcact
gaatgccaag 420atcgatccta aagcactgag ctggattctg cacgactacc
tgaagaacag aggccatttt 480tatgaggaca atagggattt caacgtgtac
ccaacaaagg agctggccaa gtacttcgat 540aagtacgggt actacaaggg
aatcattgac agcaaggagg acaatgataa caaactggag 600gaagagctga
caaagtacaa attctccaat aagcactggc tggaagaggt gaagaaagtc
660ctgtctaacc agactggcct gccagaaaag tttaaagaag agtatgagtc
actgttcagc 720tacgtgagaa attattcaga gggcccaggg agcatcaact
ctgtcagtcc ctacgggatc 780taccatctgg acgaaaaaga gggaaaggtg
gtccagaagt acaacaacat ctgggataag 840acaatcggaa agtgcaacat
cttccctgac gagtatagag ctcccaagaa cagtcctatc 900gcaatgattt
tcaatgaaat caacgagctg tccacaatca ggtcatacag catctacctg
960actggctggt tcattaatca ggagttcaag aaagcctacc tgaacaagct
gctggatctg 1020ctgatcaaaa ccaacggaga gaagccaatt gacgcaaggc
agttcaagaa actgcgcgaa 1080gagacaatcg ccgaaagcat tggcaaagag
acactgaagg atgtggagaa tgaagagaaa 1140ctggaaaagg aggaccacaa
gtggaaactg aagggactga agctgaatac caacggcaaa 1200atccagtaca
acgatctgag ctccctggct aagtttgtgc acaaactgaa gcagcatctg
1260aaactggatt tcctgctgga ggaccagtat gcaacactgg acaagatcaa
tttcctgcag 1320tccctgtttg tgtacctggg caagcacctg agatattcca
atagggtcga ttctgccaac 1380ctgaaggaat tttccgactc taacaaactg
ttcgagcgca tcctgcagaa acagaaggat 1440gggctgttca agctgtttga
acagactgac aaagacgatg agaagatcct ggcccagaca 1500catagtctgt
caactaaggc catgctgctg gctattaccc ggatgacaaa tctggacaac
1560gatgaggaca accagaaaaa caatgacaag ggctggaatt ttgaggccat
caaaaacttc 1620gatcagaagt ttatcgacat caccaagaaa aacaacaacc
tgagcctgaa acagaataag 1680cgctacctgg acgatcgatt catcaacgat
gctattctgt cccctggggt gaagcgaatc 1740ctgcgggagg caaccaaggt
ctttaatgcc attctgaaac agttctctga agagtacgac 1800gtgacaaagg
tggtcatcga actggctcgc gagctgagcg aagagaagga actggagaac
1860acaaagaact acaagaaact gatcaagaaa aacggcgaca agattagtga
gggcctgaaa 1920gcactgggga tctcagaaga tgagatcaaa gacattctga
agagtcccac taaatcatac 1980aagtttctgc tgtggctgca gcaggaccac
atcgatcctt atagcctgaa ggagatcgcc 2040ttcgacgata tttttaccaa
aacagaaaag ttcgagatcg accatatcat tccctacagc 2100atttccttcg
acgattctag ttcaaacaag ctgctggtgc tggctgaaag taatcaggca
2160aagtcaaacc agactcctta tgagttcatc agctccggaa acgcaggcat
taagtgggaa 2220gattacgagg cctattgccg caagttcaag gatggggact
ctagtctgct ggacagcacc 2280cagcggtcca agaaattcgc caaaatgatg
aaaaccgata cctcaagcaa gtacgacatc 2340ggatttctgg ctcgaaatct
gaacgatact cggtacgcaa ccattgtgtt ccgggacgcc 2400ctggaggact
atgctaataa ccacctggtc gaggacaaac ccatgtttaa ggtggtctgt
2460atcaatgggt ccgtgacctc tttcctgcgg aagaactttg acgattcctc
ttacgccaag 2520aaagatagag acaagaatat ccaccatgct gtggatgcaa
gtatcatctc aattttcagc 2580aacgagacaa agactctgtt caaccagctg
actcagtttg ctgactataa actgttcaag 2640aacaccgatg gcagctggaa
gaaaatcgac cctaagacag gggtggtcac tgaagtgacc 2700gacgagaatt
ggaagcagat tagggtgcgc aaccaggtga gcgaaatcgc caaagtcatt
2760gagaagtaca tccaggatag caacatcgaa agaaaggcta ggtattcccg
caaaatcgag 2820aataagacta acatttccct gtttaatgac accgtgtact
ctgccaagaa agtcggctat 2880gaggatcaga tcaaaagaaa gaacctgaaa
accctggaca ttcacgaatc tgctaaagag 2940aataagaaca gtaaagtgaa
gcggcagttt gtctacagaa agctggtgaa tgtcagcctg 3000ctgaataacg
ataagctggc agacctgttc gccgaaaaag aggatatcct gatgtatagg
3060gccaatccat gggtcatcaa cctggctgag cagattttca atgaatacac
tgagaacaag 3120aaaatcaagt cccagaacgt gtttgaaaaa tatatgctgg
acctgaccaa agagttcccc 3180gagaagttca gcgagtttct ggtgaagtcc
atgctgagaa acaagaccgc catcatctac 3240gacgataaga aaaacattgt
ccatcgaatc aaacggctga agatgctgag ttcagaactg 3300aaagagaata
agctgtctaa cgtgatcatt aggtctaaga atcagagtgg gaccaaactg
3360tcataccagg atacaatcaa cagcctggcc ctgatgatta tgcgcagcat
cgaccctact 3420gctaagaaac agtatattcg agtgccactg aataccctga
acctgcacct gggagatcat 3480gactttgatc tgcacaatat ggatgcttac
ctgaagaaac caaaattcgt gaagtatctg 3540aaagcaaacg aaatcggcga
cgagtacaag ccctggaggg tcctgacatc tggcactctg 3600ctgatccata
agaaggataa gaaactgatg tacatcagct ccttccagaa tctgaacgac
3660gtgatcgaaa ttaagaatct gatcgaaacc gagtataaag agaacgacga
ttctgatagt 3720aagaaaaaga aaaaggcaaa ccgctttctg atgaccctga
gcacaatcct gaatgactac 3780attctgctgg acgccaagga taacttcgac
atcctggggc tgtctaaaaa tcggatcgat 3840gagattctga acagtaagct
gggactggac aagattgtga aataagaatt c 38911373093DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
137accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtccatgag gattctgggg tttgacattg gcattaacag
catcgggtgg 120gcttttgtgg agaacgacga actgaaggac tgcggagtgc
ggatcttcac aaaggccgag 180aacccaaaaa ataaggaaag cctggcactg
ccccggagaa atgcacgcag ctccaggcgc 240cgactgaaac ggagaaaggc
ccggctgatc gctattaaga gaatcctggc caaagagctg 300aagctgaact
acaaggacta tgtcgcagct gatggagagc tgccaaaggc ctacgaagga
360tccctggcat ctgtgtacga gctgcggtat aaggccctga cacagaacct
ggaaactaaa 420gatctggcca gagtgatcct gcacattgct aagcataggg
ggtacatgaa caagaacgag 480aagaaatcaa acgacgctaa gaaaggaaag
atcctgagcg ctctgaaaaa caatgcactg 540aagctggaga actaccagag
cgtgggcgaa tacttctaca aggagttctt tcagaaatac 600aagaaaaaca
caaagaactt catcaagatc cgcaacacta aggataatta caacaattgc
660gtgctgtcta gtgacctgga aaaagagctg aagctgatcc tggaaaaaca
gaaggagttc 720ggctacaact actctgaaga tttcatcaac gagattctga
aggtcgcctt ctttcagcgg 780cccctgaagg acttcagtca cctggtgggg
gcctgcactt tctttgagga agagaaaagg 840gcctgtaaga acagctactc
tgcctgggag tttgtggctc tgaccaagat cattaacgag 900atcaagagcc
tggagaagat cagcggcgaa attgtgccaa cccagacaat caacgaggtc
960ctgaatctga tcctggacaa ggggtctatc acctacaaga aattcagaag
ttgtatcaat 1020ctgcatgaga gtatcagctt caagagcctg aagtatgata
aagaaaacgc cgagaatgct 1080aaactgatcg acttccgcaa gctggtggag
tttaagaaag ccctgggagt ccacagcctg 1140tcccggcagg aactggatca
gatctccact catatcaccc tgattaagga caacgtgaag 1200ctgaaaaccg
tcctggagaa atacaacctg agtaatgaac agatcaacaa tctgctggaa
1260attgagttca acgattatat caacctgagc ttcaaggccc tgggaatgat
tctgccactg 1320atgcgcgagg gcaaacgata cgacgaggcc tgcgagatcg
ccaatctgaa acctaagacc 1380gtggacgaga agaaagattt cctgccagca
ttttgtgatt ccattttcgc ccacgagctg 1440tctaaccccg tggtcaatag
ggctatcagc gaataccgca aggtgctgaa cgcactgctg 1500aagaaatatg
gaaaggtcca caaaattcat ctggagctgg ctcgcgacgt gggcctgtcc
1560aagaaagcac gagagaagat cgaaaaagag cagaaggaaa accaggccgt
gaatgcatgg 1620gccctgaagg aatgcgagaa tattggcctg aaggccagcg
caaagaacat cctgaaactg 1680aagctgtgga aagaacagaa ggagatctgt
atctactccg gaaataagat ctctattgag 1740cacctgaaag atgaaaaggc
cctggaggtg gaccatatct acccctattc taggagtttc 1800gacgattctt
ttatcaacaa agtgctggtg ttcaccaagg aaaatcagga gaaactgaac
1860aagacacctt tcgaggcctt tggcaagaat attgaaaaat ggagcaagat
ccagaccctg 1920gctcagaacc tgccatacaa gaaaaagaat aagattctgg
acgagaactt caaagataag 1980cagcaggagg actttatctc tcgaaatctg
aacgacaccc ggtatatcgc tacactgatt 2040gcaaaataca caaaggagta
tctgaacttc ctgctgctga gcgaaaatga gaacgccaat 2100ctgaagagtg
gcgaaaaagg gtcaaagatc cacgtgcaga ctattagcgg gatgctgacc
2160tccgtcctga ggcacacatg ggggtttgac aaaaaggatc gcaacaatca
tctgcaccat 2220gcactggatg ccatcattgt ggcctacagt acaaattcaa
tcattaaggc tttcagcgat 2280ttccggaaaa accaggagct gctgaaggcc
agattctacg ctaaagaact gacttccgat 2340aactataaac atcaggtcaa
gttctttgag cctttcaaga gttttagaga aaaaatcctg 2400tcaaagatcg
acgagatttt cgtgtccaaa ccacctcgaa agcgagctag gcgcgcactg
2460cacaaggata cctttcattc tgagaacaag atcattgaca agtgcagcta
caactccaag 2520gaaggcctgc agattgccct gagctgtgga agagtgagga
aaatcggcac taagtatgtc 2580gagaatgata ccatcgtgag ggtcgacatt
ttcaaaaagc agaacaagtt ttacgctatc 2640ccaatctacg caatggattt
tgccctgggg atcctgccca ataagatcgt gattactgga 2700aaagataaga
acaataaccc caaacagtgg cagaccattg acgaatcata cgagttctgc
2760tttagcctgt ataagaatga cctgatcctg ctgcagaaaa agaacatgca
ggaacctgag 2820ttcgcctact ataacgattt ttcaatcagc acatcaagca
tttgtgtgga gaaacacgac 2880aacaagttcg aaaatctgac tagcaaccag
aagctgctgt tttccaatgc aaaagagggc 2940tctgtgaagg tcgaaagtct
ggggatccag aacctgaaag tgttcgagaa gtacatcatt 3000acccccctgg
gagataaaat taaggctgac tttcagcctc gagaaaacat cagcctgaaa
3060accagtaaaa agtatggcct gaggtaagaa ttc 30931384104DNAHomo
sapiensCDS(1)..(4104) 138atg gac aag aag tac agc atc ggc ctg gac
atc ggc acc aac tct gtg 48Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp
Ile Gly Thr Asn Ser Val 1 5 10
15 ggc tgg gcc gtg atc acc gac gag tac aag gtg ccc agc aag aaa ttc
96Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe
20 25 30 aag gtg ctg ggc aac acc gac cgg cac agc atc aag aag aac
ctg atc 144Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn
Leu Ile 35 40 45 gga gcc ctg ctg ttc gac agc ggc gaa aca gcc gag
gcc acc cgg ctg 192Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu
Ala Thr Arg Leu 50 55 60 aag aga acc gcc aga aga aga tac acc aga
cgg aag aac cgg atc tgc 240Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg
Arg Lys Asn Arg Ile Cys 65 70 75 80 tat ctg caa gag atc ttc agc aac
gag atg gcc aag gtg gac gac agc 288Tyr Leu Gln Glu Ile Phe Ser Asn
Glu Met Ala Lys Val Asp Asp Ser 85 90 95 ttc ttc cac aga ctg gaa
gag tcc ttc ctg gtg gaa gag gat aag aag 336Phe Phe His Arg Leu Glu
Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 cac gag cgg cac
ccc atc ttc ggc aac atc gtg gac gag gtg gcc tac 384His Glu Arg His
Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 cac gag
aag tac ccc acc atc tac cac ctg aga aag aaa ctg gtg gac 432His Glu
Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140
agc acc gac aag gcc gac ctg cgg ctg atc tat ctg gcc ctg gcc cac
480Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His
145 150 155 160 atg atc aag ttc cgg ggc cac ttc ctg atc gag ggc gac
ctg aac ccc 528Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp
Leu Asn Pro 165 170 175 gac aac agc gac gtg gac aag ctg ttc atc cag
ctg gtg cag acc tac 576Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln
Leu Val Gln Thr Tyr 180 185 190 aac cag ctg ttc gag gaa aac ccc atc
aac gcc agc ggc gtg gac gcc 624Asn Gln Leu Phe Glu Glu Asn Pro Ile
Asn Ala Ser Gly Val Asp Ala 195 200 205 aag gcc atc ctg tct gcc aga
ctg agc aag agc aga cgg ctg gaa aat 672Lys Ala Ile Leu Ser Ala Arg
Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 ctg atc gcc cag ctg
ccc ggc gag aag aag aat ggc ctg ttc ggc aac 720Leu Ile Ala Gln Leu
Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 ctg att
gcc ctg agc ctg ggc ctg acc ccc aac ttc aag agc aac ttc 768Leu Ile
Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255
gac ctg gcc gag gat gcc aaa ctg cag ctg agc aag gac acc tac gac
816Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp
260 265 270 gac gac ctg gac aac ctg ctg gcc cag atc ggc gac cag tac
gcc gac 864Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr
Ala Asp 275 280 285 ctg ttt ctg gcc gcc aag aac ctg tcc gac gcc atc
ctg ctg agc gac 912Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile
Leu Leu Ser Asp 290 295 300 atc ctg aga gtg aac acc gag atc acc aag
gcc ccc ctg agc gcc tct 960Ile Leu Arg Val Asn Thr Glu Ile Thr Lys
Ala Pro Leu Ser Ala Ser 305 310 315 320 atg atc aag aga tac gac gag
cac cac cag gac ctg acc ctg ctg aaa 1008Met Ile Lys Arg Tyr Asp Glu
His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 gct ctc gtg cgg cag
cag ctg cct gag aag tac aaa gag att ttc ttc 1056Ala Leu Val Arg Gln
Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 gac cag agc
aag aac ggc tac gcc ggc tac att gac ggc gga gcc agc 1104Asp Gln Ser
Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 cag
gaa gag ttc tac aag ttc atc aag ccc atc ctg gaa aag atg gac 1152Gln
Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375
380 ggc acc gag gaa ctg ctc gtg aag ctg aac aga gag gac ctg ctg cgg
1200Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg
385 390 395 400 aag cag cgg acc ttc gac aac ggc agc atc ccc cac cag
atc cac ctg 1248Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln
Ile His Leu 405 410 415 gga gag ctg cac gcc att ctg cgg cgg cag gaa
gat ttt tac cca ttc 1296Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu
Asp Phe Tyr Pro Phe 420 425 430 ctg aag gac aac cgg gaa aag atc gag
aag atc ctg acc ttc cgc atc 1344Leu Lys Asp Asn Arg Glu Lys Ile Glu
Lys Ile Leu Thr Phe Arg Ile 435 440 445 ccc tac tac gtg ggc cct ctg
gcc agg gga aac agc aga ttc gcc tgg 1392Pro Tyr Tyr Val Gly Pro Leu
Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 atg acc aga aag agc
gag gaa acc atc acc ccc tgg aac ttc gag gaa 1440Met Thr Arg Lys Ser
Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 gtg gtg
gac aag ggc gct tcc gcc cag agc ttc atc gag cgg atg acc 1488Val Val
Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485 490 495
aac ttc gat aag aac ctg ccc aac gag aag gtg ctg ccc aag cac agc
1536Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser
500 505 510 ctg ctg tac gag tac ttc acc gtg tat aac gag ctg acc aaa
gtg aaa 1584Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys
Val Lys 515 520 525 tac gtg acc gag gga atg aga aag ccc gcc ttc ctg
agc ggc gag cag 1632Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu
Ser Gly Glu Gln 530 535 540 aaa aag gcc atc gtg gac ctg ctg ttc aag
acc aac cgg aaa gtg acc 1680Lys Lys Ala Ile Val Asp Leu Leu Phe Lys
Thr Asn Arg Lys Val Thr 545 550 555 560 gtg aag cag ctg aaa gag gac
tac ttc aag aaa atc gag tgc ttc gac 1728Val Lys Gln Leu Lys Glu Asp
Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 tcc gtg gaa atc tcc
ggc gtg gaa gat cgg ttc aac gcc tcc ctg ggc 1776Ser Val Glu Ile Ser
Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 aca tac cac
gat ctg ctg aaa att atc aag gac aag gac ttc ctg gac 1824Thr Tyr His
Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 aat
gag gaa aac gag gac att ctg gaa gat atc gtg ctg acc ctg aca 1872Asn
Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615
620 ctg ttt gag gac aga gag atg atc gag gaa cgg ctg aaa acc tat gcc
1920Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala
625 630 635 640 cac ctg ttc gac gac aaa gtg atg aag cag ctg aag cgg
cgg aga tac 1968His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg
Arg Arg Tyr 645 650 655 acc ggc tgg ggc agg ctg agc cgg aag ctg atc
aac ggc atc cgg gac 2016Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile
Asn Gly Ile Arg Asp 660 665 670 aag cag tcc ggc aag aca atc ctg gat
ttc ctg aag tcc gac ggc ttc 2064Lys Gln Ser Gly Lys Thr Ile Leu Asp
Phe Leu Lys Ser Asp Gly Phe 675 680 685 gcc aac aga aac ttc atg cag
ctg atc cac gac gac agc ctg acc ttt 2112Ala Asn Arg Asn Phe Met Gln
Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 aaa gag gac atc cag
aaa gcc cag gtg tcc ggc cag ggc gat agc ctg 2160Lys Glu Asp Ile Gln
Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720 cac gag
cac att gcc aat ctg gcc ggc agc ccc gcc att aag aag ggc 2208His Glu
His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735
atc ctg cag aca gtg aag gtg gtg gac gag ctc gtg aaa gtg atg ggc
2256Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly
740 745 750 cgg cac aag ccc gag aac atc gtg atc gcc atg gcc aga gag
aac cag 2304Arg His Lys Pro Glu Asn Ile Val Ile Ala Met Ala Arg Glu
Asn Gln 755 760 765 acc acc cag aag gga cag aag aac agc cgc gag aga
atg aag cgg atc 2352Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg
Met Lys Arg Ile 770 775 780 gaa gag ggc atc aaa gag ctg ggc agc cag
atc ctg aaa gaa cac ccc 2400Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln
Ile Leu Lys Glu His Pro 785 790 795 800 gtg gaa aac acc cag ctg cag
aac gag aag ctg tac ctg tac tac ctg 2448Val Glu Asn Thr Gln Leu Gln
Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 cag aat ggg cgg gat
atg tac gtg gac cag gaa ctg gac atc aac cgg 2496Gln Asn Gly Arg Asp
Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 ctg tcc gac
tac gat gtg gac gcc atc gtg cct cag agc ttt ctg aag 2544Leu Ser Asp
Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 835 840 845 gac
gac tcc atc gac gcc aag gtg ctg acc aga agc gac aag gcc cgg 2592Asp
Asp Ser Ile Asp Ala Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 850 855
860 ggc aag agc gac aac gtg ccc tcc gaa gag gtc gtg aag aag atg aag
2640Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys
865 870 875 880 aac tac tgg cgg cag ctg ctg aac gcc aag ctg att acc
cag aga aag 2688Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr
Gln Arg Lys 885 890 895 ttc gac aat ctg acc aag gcc gag aga ggc ggc
ctg agc gaa ctg gat 2736Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly
Leu Ser Glu Leu Asp 900 905 910 aag gcc ggc ttc atc aag aga cag ctg
gtg gaa acc cgg cag atc aca 2784Lys Ala Gly Phe Ile Lys Arg Gln Leu
Val Glu Thr Arg Gln Ile Thr 915 920 925 aag cac gtg gca cag atc ctg
gac tcc cgg atg aac act aag tac gac 2832Lys His Val Ala Gln Ile Leu
Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 gag aat gac aag ctg
atc cgg gaa gtg aaa gtg atc acc ctg aag tcc 2880Glu Asn Asp Lys Leu
Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945 950 955 960 aag ctg
gtg tcc gat ttc cgg aag gat ttc cag ttt tac aaa gtg cgc 2928Lys Leu
Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 965 970 975
gag atc aac aac tac cac cac gcc cac gcc gcc tac ctg aac gcc gtc
2976Glu Ile Asn Asn Tyr His His Ala His Ala Ala Tyr Leu Asn Ala Val
980 985 990 gtg gga acc gcc ctg atc aaa aag tac cct aag ctg gaa agc
gag ttc 3024Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser
Glu Phe 995 1000 1005 gtg tac ggc gac tac aag gtg tac gac gtg cgg
aag atg atc gcc 3069Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys
Met Ile Ala 1010 1015 1020 aag agc gag cag gaa atc ggc aag gct acc
gcc aag tac ttc ttc 3114Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala
Lys Tyr Phe Phe 1025 1030 1035 tac agc aac atc atg aac ttt ttc aag
acc gag att acc ctg gcc 3159Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr
Glu Ile Thr Leu Ala 1040 1045 1050 aac ggc gag atc cgg aag cgg cct
ctg atc gag aca aac ggc gaa 3204Asn Gly Glu Ile Arg Lys Arg Pro Leu
Ile Glu Thr Asn Gly Glu 1055 1060 1065 acc ggg gag atc gtg tgg gat
aag ggc cgg gat ttt gcc acc gtg 3249Thr Gly Glu Ile Val Trp Asp Lys
Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 cgg aaa gtg ctg agc atg
ccc caa gtg aat atc gtg aaa aag acc 3294Arg Lys Val Leu Ser Met Pro
Gln Val Asn Ile Val Lys Lys Thr 1085 1090 1095 gag gtg cag aca ggc
ggc ttc agc aaa gag tct atc ctg ccc aag 3339Glu Val Gln Thr Gly Gly
Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 agg aac agc gat
aag ctg atc gcc aga aag aag gac tgg gac cct 3384Arg Asn Ser Asp Lys
Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 aag aag tac
ggc ggc ttc gac agc ccc acc gtg gcc tat tct gtg 3429Lys Lys Tyr Gly
Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 ctg gtg
gtg gcc aaa gtg gaa aag ggc aag tcc aag aaa ctg aag 3474Leu Val Val
Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150 1155 agt
gtg aaa gag ctg ctg ggg atc acc atc atg gaa aga agc agc 3519Ser Val
Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170
ttc gag aag aat ccc atc gac ttt ctg gaa gcc aag ggc tac aaa 3564Phe
Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180
1185 gaa gtg aaa aag gac ctg atc atc aag ctg cct aag tac tcc ctg
3609Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu
1190 1195 1200 ttc gag ctg gaa aac ggc cgg aag aga atg ctg gcc tct
gcc ggc 3654Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala
Gly 1205 1210 1215 gaa ctg cag aag gga aac gaa ctg gcc ctg ccc tcc
aaa tat gtg 3699Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys
Tyr Val 1220 1225 1230 aac ttc ctg tac ctg gcc agc cac tat gag aag
ctg aag ggc tcc 3744Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu
Lys Gly Ser 1235 1240 1245 ccc gag gat aat gag cag aaa cag ctg ttt
gtg gaa cag cac aag 3789Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val
Glu Gln His Lys 1250 1255 1260 cac tac ctg gac gag atc atc gag cag
atc agc gag ttc tcc aag 3834His Tyr Leu Asp Glu Ile Ile Glu Gln Ile
Ser Glu Phe Ser Lys 1265 1270 1275 aga gtg atc ctg gcc gac gct aat
ctg gac aaa gtg ctg tcc gcc 3879Arg Val Ile Leu Ala Asp Ala Asn Leu
Asp Lys Val Leu Ser Ala 1280 1285 1290 tac aac aag cac cgg gat aag
ccc atc aga gag cag gcc gag aat 3924Tyr Asn Lys His Arg Asp Lys Pro
Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 atc atc cac ctg ttt acc
ctg acc aat ctg gga gcc cct gcc gcc 3969Ile Ile His Leu Phe Thr Leu
Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315 1320 ttc aag tac ttt gac
acc acc atc gac cgg aag agg tac acc agc 4014Phe Lys Tyr Phe Asp Thr
Thr Ile Asp Arg Lys Arg Tyr Thr Ser
1325 1330 1335 acc aaa gag gtg ctg gac gcc acc ctg atc cac cag agc
atc acc 4059Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile
Thr 1340 1345 1350 ggc ctg tac gag aca cgg atc gac ctg tct cag ctg
gga ggc gac 4104Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly
Gly Asp 1355 1360 1365 1391368PRTHomo sapiens 139Met Asp Lys Lys
Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 1 5 10 15 Gly Trp
Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30
Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35
40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg
Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn
Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala
Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe
Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe
Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro
Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp
Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160
Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165
170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr
Tyr 180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly
Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser
Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly Glu Lys
Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu
Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu
Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp
Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275 280 285
Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290
295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala
Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu
Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro Glu Lys
Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly Tyr Ala
Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe Tyr Lys
Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu
Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys
Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 405 410
415 Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe
420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe
Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser
Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr
Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser
Ala Gln Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn
Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr
Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr
Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535
540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr
545 550 555 560 Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu
Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe
Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile
Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile
Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg
Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu
Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655
Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660
665 670 Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly
Phe 675 680 685 Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser
Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly
Gln Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala
Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys
Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro
Glu Asn Ile Val Ile Ala Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr
Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780
Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785
790 795 800 Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr
Tyr Leu 805 810 815 Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu
Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp Ala Ile Val
Pro Gln Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Ala Lys Val
Leu Thr Arg Ser Asp Lys Ala Arg 850 855 860 Gly Lys Ser Asp Asn Val
Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp
Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 885 890 895 Phe
Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905
910 Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr
915 920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys
Tyr Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile
Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp
Phe Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His
Ala His Ala Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu
Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr
Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020
Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025
1030 1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu
Ala 1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr
Asn Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg
Asp Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln
Val Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly
Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp
Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys
Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140
Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145
1150 1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser
Ser 1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys
Gly Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu
Pro Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys
Arg Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn
Glu Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr
Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu
Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260
His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265
1270 1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser
Ala 1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln
Ala Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu
Gly Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile
Asp Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp
Ala Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu
Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355 1360 1365
140155RNASuterella wadsworthensis 140guuucagugc uauaggaaac
uauaggaaau caccuucggg ugagcugaaa uccccuaaag 60cuaagauuga auccggccac
uaucuauuag uagauauccg gauauucuga uauaaaaccu 120cauucuuuga
uuagaccaaa ggaugagguu uuuuu 155141107RNATreponema denticola
141guuugagagu uggaaacaac gaguucaaau aagaauucau caaaaucguc
ccuuuuggga 60ccgcucauug uggagcauca aggcuuaaca ugguuaagcc uuuuuuu
10714299RNAFilifactor alocis 142guuugagagu aggaaacuac acgguucaaa
uaaagaauuu uucuaaucgc ccaaugggcc 60cauauugaua uggaugaaac ucgcuuagcg
aguuuuuuu 9914391RNAStaphylococcus pseudintermedius 143guuuuagcac
uagaaauagu uaaguuaaaa caagcuuaaa gcgucaaugu aauauuuuau 60uaacacccua
cugugucagu gggguuuuuu u 9114494RNALactobacillus johnsonii
144guuuuagaug gugaaaacca gauuuaaaau caagcaaugc aucuuuugau
gcaaaguuuc 60aauauuuguc ccacguuauc gagggacuuu uuuu
9414578RNAEubacterium ventriosum 145auuuuaguac cuggaaacag
aucuacuaaa acaaggcuuu augccgaaau caagagcacc 60gacgggugcu cuuuuuuu
7814684RNAStreptococcus pasteurianus 146guuuuuguac ucgaaagagc
cuacaaagau aaggcuuuau gccgaauuca agcaccccau 60guuuugacau gaggugcuuu
uuuu 8414785RNALactobacillus farciminis 147guuuuuguac cuuagaaaua
agaucuacaa aaauaaggau uuauuccgaa uuuaccaccu 60auuuuaauua auaggugguu
uuuuu 85148100RNABacteroides coprophilus 148guugugauuu gcuuucauuu
gaaaaauuga agcaaaucac aauaaggauu auuccguugu 60gaaaacaauu aaagcggucu
ugcaaaaggu cgcuuuuuuu 100149102RNAFlaviivola taffensis
149guugugauuc gcuuucaaug aaaauugaag cgaaucacaa uaaggauuau
uccguuguga 60aaacauuuac uacggggcau cgaaagacug ccucguuuuu uu
10215090RNAFlavobacterium columnare 150guugugguuu gauuagaaau
aaucuuauca caauaaggcu auaugccgua gacgaaaguc 60uuuagucccg cuucgguggg
acuuuuuuuu 9015178RNASphaerochaeta globus 151guuggggaug accgcgaaag
cgauuaucuc uaauaagacu uaagucgcaa aaugcucccu 60auuuugggag cuuuuuuu
7815285RNAAzospirillum sp. 152guugcggcug gagaaaucca gccguuaaca
uguucccuuc ggggagcacg aaaugcgggg 60cgggccacgg uccgccccuu uuuuu
85153126RNAGluconacetobacter diazotrophicus 153gccgugguuu
ccgaaaggaa accacgguaa cagaauuacc guaagguuuu uucugugaag 60gaucaucccu
cgcuugggca accaggcggg ggaaauuccu cguucgggcc aaucagcccu 120uuuuuu
12615482RNARoseburia intestinalis 154guuguaauuc ccugaaaagg
uuauuacaau aagguaagaa accuaaaagc ucuaauccca 60uucuucggaa ugggauuuuu
uu 8215583RNAStaphylococcus aureus 155guuuuaguac ucuggaaaca
gaaucuacua aaacaaggca aaaugccgug uuuaucucgu 60caacuuguug gcgagauuuu
uuu 8315694RNAMycoplasma gallisepticum 156guuuuagcac uguacaagaa
auugucgugc uaaaauaagg cgcuguuaau gcagcugccg 60cauccgccag agcauuuaug
cucuggcuuu uuuu 94157117RNACampylobacter lari 157guuuuagucu
cugaaaagag acuaaaauaa gugguuuuug gucauccacg caggguuaca 60aucccuuuaa
aaccauuaaa auucaaauaa acuagguugu aucaacuuag uuuuuuu
117158119RNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 158nnnnnnnnnn nnnnnnnnnn acugggguuc
aggaaacuga accucaguaa gcauuggcuc 60guuuccaaug uugauugcuc cgccggugcu
ccuuauuuuu aagggcgccg gcuuuuuuu 1191591084PRTCorynebacterium
diphtheriae 159Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser
Val Gly Leu 1 5 10 15 Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro
Ile Lys Thr Leu Ser 20 25 30 Leu Val Ser His Ile His Asp Ser Gly
Leu Asp Pro Asp Glu Ile Lys 35 40 45 Ser Ala Val Thr Arg Leu Ala
Ser Ser Gly Ile Ala Arg Arg Thr Arg 50 55 60 Arg Leu Tyr Arg Arg
Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 65 70 75 80 Ile Gln Arg
Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 85 90 95 Pro
Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 100 105
110 Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His
115 120 125 Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val
Ser Ser 130 135 140 Leu Tyr Leu Pro Asp Gly Pro Ser Asp Ala Phe Lys
Ala Ile Arg Glu 145 150 155 160 Glu Ile Lys Arg Ala Ser Gly Gln Pro
Val Pro Glu Thr Ala Thr Val 165 170 175 Gly Gln Met Val Thr Leu Cys
Glu Leu Gly Thr Leu Lys Leu Arg Gly 180 185 190 Glu Gly Gly Val Leu
Ser Ala Arg Leu Gln Gln Ser Asp Tyr Ala Arg 195 200 205 Glu Ile Gln
Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 210 215 220 Arg
Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 225 230
235 240 Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn
Arg 245 250 255 Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile
Ala Ala Leu 260 265 270 Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu
Lys Arg Ile Leu Ser 275 280 285 Val Glu Glu Lys Asn Leu Val Phe Asp
His Leu Val Asn Leu Thr Pro 290 295 300 Lys Lys Glu Pro Glu Trp Val
Thr Ile Ala Glu Ile Leu Gly Ile Asp 305 310 315 320 Arg Gly Gln Leu
Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 325 330 335 Ala Gly
Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 340 345 350
Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 355
360 365 Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp
Asp 370 375
380 Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu
385 390 395 400 Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu
Pro Val Gly 405 410 415 Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg
Leu Thr Arg Arg Met 420 425 430 Leu Ser Asp Gly Val Asp Leu Tyr Thr
Ala Arg Leu Gln Glu Phe Gly 435 440 445 Ile Glu Pro Ser Trp Thr Pro
Pro Thr Pro Arg Ile Gly Glu Pro Val 450 455 460 Gly Asn Pro Ala Val
Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 465 470 475 480 Glu Ser
Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 485 490 495
His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 500
505 510 Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln
Glu 515 520 525 Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg
Ala Asp Leu 530 535 540 Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys
Gln Cys Ala Tyr Cys 545 550 555 560 Gly Ser Pro Ile Thr Phe Ser Asn
Ser Glu Met Asp His Ile Val Pro 565 570 575 Arg Ala Gly Gln Gly Ser
Thr Asn Thr Arg Glu Asn Leu Val Ala Val 580 585 590 Cys His Arg Cys
Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 595 600 605 Ala Lys
Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 610 615 620
Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 625
630 635 640 Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala
Thr Met 645 650 655 Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val
Ala Trp Met Ala 660 665 670 Asn Glu Leu Arg Ser Arg Val Ala Gln His
Phe Ala Ser His Gly Thr 675 680 685 Thr Val Arg Val Tyr Arg Gly Ser
Leu Thr Ala Glu Ala Arg Arg Ala 690 695 700 Ser Gly Ile Ser Gly Lys
Leu Lys Phe Phe Asp Gly Val Gly Lys Ser 705 710 715 720 Arg Leu Asp
Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 725 730 735 Thr
Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 740 745
750 Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr
755 760 765 Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys
Gln Lys 770 775 780 Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu
Arg Asp Asp Arg 785 790 795 800 Val Val Val Met Ser Asn Val Arg Leu
Arg Leu Gly Asn Gly Ser Ala 805 810 815 His Lys Glu Thr Ile Gly Lys
Leu Ser Lys Val Lys Leu Ser Ser Gln 820 825 830 Leu Ser Val Ser Asp
Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 835 840 845 Ala Leu Thr
Arg Glu Pro Gly Phe Asp Pro Lys Glu Gly Leu Pro Ala 850 855 860 Asn
Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 865 870
875 880 Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu
Arg 885 890 895 Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala
Arg Val Tyr 900 905 910 Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala
Met Leu Arg Val Tyr 915 920 925 Thr Ile Asp Leu Leu Pro Tyr Arg Asn
Gln Asp Leu Phe Ser Val Glu 930 935 940 Leu Lys Pro Gln Thr Met Ser
Met Arg Gln Ala Glu Lys Lys Leu Arg 945 950 955 960 Asp Ala Leu Ala
Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 965 970 975 Asp Asp
Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 980 985 990
Lys Ala Val Glu Ala Glu Leu Gly Thr Ile Arg Arg Trp Arg Val Asp 995
1000 1005 Gly Phe Phe Ser Pro Ser Lys Leu Arg Leu Arg Pro Leu Gln
Met 1010 1015 1020 Ser Lys Glu Gly Ile Lys Lys Glu Ser Ala Pro Glu
Leu Ser Lys 1025 1030 1035 Ile Ile Asp Arg Pro Gly Trp Leu Pro Ala
Val Asn Lys Leu Phe 1040 1045 1050 Ser Asp Gly Asn Val Thr Val Val
Arg Arg Asp Ser Leu Gly Arg 1055 1060 1065 Val Arg Leu Glu Ser Thr
Ala His Leu Pro Val Thr Trp Lys Val 1070 1075 1080 Gln
1603336DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 160accggtgcca ccatgtaccc atacgatgtt
ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag cgtccatgaa gtaccatgtc
ggaatcgatg tcggaacctt ttctgtgggg 120ctggctgcta ttgaagtgga
tgacgctgga atgcctatta agaccctgag tctggtgtca 180cacattcatg
actcaggact ggatcctgac gagatcaaga gcgctgtgac caggctggca
240agctccggaa tcgcccggag aacaaggcgc ctgtaccgac ggaagagaag
gcgcctgcag 300cagctggata agttcatcca gaggcagggc tggccagtga
tcgagctgga agattacagc 360gaccccctgt atccttggaa ggtgcgcgcc
gaactggccg cttcttatat tgctgacgag 420aaggaacggg gggagaaact
gagtgtggct ctgagacaca tcgcaaggca tcgcggatgg 480aggaaccctt
acgccaaggt gtctagtctg tatctgccag atggcccctc agacgccttc
540aaggctatta gggaggaaat caaacgcgct agcggccagc ctgtgccaga
gactgcaacc 600gtcgggcaga tggtgaccct gtgcgaactg ggcacactga
agctgcgagg agagggagga 660gtgctgagtg cacggctgca gcagtcagat
tacgcccgcg agatccagga aatttgtcga 720atgcaggaga tcggccagga
actgtatcgc aagatcattg acgtggtgtt cgcagccgag 780tccccaaagg
gctctgcctc aagccgggtg gggaaagatc ctctgcagcc aggaaagaac
840agagcactga aagccagcga cgcttttcag cgataccgga ttgctgcact
gatcggcaat 900ctgagagtca gggtggatgg ggagaagagg attctgagcg
tggaggagaa gaacctggtg 960ttcgaccacc tggtgaatct gactccaaag
aaagagcccg aatgggtgac catcgccgaa 1020attctgggca tcgatcgcgg
gcagctgatc ggaacagcta ctatgaccga cgatggagag 1080cgagcaggag
cccgaccccc tacacacgat actaacagaa gtattgtgaa cagccggatc
1140gcaccactgg tcgactggtg gaaaacagct agcgcactgg agcagcacgc
catggtgaag 1200gcactgtcca acgccgaagt cgacgatttt gattctcccg
agggagcaaa agtgcaggca 1260ttctttgccg atctggacga tgacgtccac
gccaagctgg acagcctgca tctgcctgtg 1320ggacgagcag cttactccga
ggacactctg gtcagactga cccgacggat gctgagtgat 1380ggggtggacc
tgtataccgc ccggctgcag gagttcggaa ttgaacctag ctggacccca
1440cccacaccaa gaatcggaga gcctgtcggc aatccagccg tcgaccgggt
gctgaaaaca 1500gtgagcagat ggctggaatc cgcaacaaag acttggggcg
ccccagagag ggtcatcatt 1560gagcacgtgc gcgaaggctt cgtcactgag
aaacgcgctc gagaaatgga tggggacatg 1620agaaggcgcg cagcccggaa
cgccaagctg tttcaggaga tgcaggaaaa gctgaatgtg 1680cagggcaaac
ccagtcgagc cgatctgtgg agataccagt cagtgcagag acagaactgc
1740cagtgtgcct attgcgggtc cccaattacc ttttctaata gtgaaatgga
ccacatcgtg 1800cccagagcag ggcagggatc caccaacaca agggagaatc
tggtcgccgt gtgccatcgc 1860tgtaaccagt ctaagggcaa tacacccttc
gctatttggg caaaaaacac ttctatcgaa 1920ggggtcagtg tgaaggaggc
cgtggaacgg accagacatt gggtcactga taccggcatg 1980agaagcactg
acttcaagaa gttcaccaag gctgtggtcg agcggtttca gagagcaaca
2040atggatgagg aaatcgacgc cagaagcatg gaatccgtcg cctggatggc
taatgagctg 2100aggagccgcg tggctcagca cttcgcatcc catggaacca
cagtcagggt gtaccgaggc 2160agcctgacag cagaggctcg acgggcatct
gggatcagtg gaaagctgaa attctttgat 2220ggcgtgggga agtccaggct
ggatagaagg caccatgcta ttgacgctgc agtgatcgca 2280ttcacctctg
actatgtggc cgaaacactg gctgtccgct caaacctgaa acagagccag
2340gcccaccgac aggaggctcc tcagtggaga gagttcaccg gcaaggatgc
agagcatcga 2400gcagcttgga gagtgtggtg ccagaagatg gaaaaactga
gcgccctgct gaccgaggac 2460ctgcgagatg accgggtggt cgtgatgtct
aacgtgcgac tgcggctggg aaatggcagt 2520gcccacaagg aaaccattgg
caaactgtca aaggtgaaac tgtcctctca gctgtcagtc 2580agcgatatcg
acaaagcaag ttcagaggcc ctgtggtgtg ctctgaccag agagcccgga
2640ttcgatccta aggaaggcct gcccgctaac cctgagagac acatcagggt
gaatgggaca 2700catgtctacg ccggggacaa tattggactg tttccagtgt
cagcaggaag catcgcactg 2760aggggaggat acgcagagct gggcagctcc
ttccaccatg ctcgcgtgta taaaattact 2820tccggcaaga aacccgcatt
tgccatgctg agggtgtaca ccatcgatct gctgccttat 2880cgcaaccagg
acctgtttag cgtggaactg aagccacaga caatgtccat gaggcaggct
2940gagaagaaac tgcgcgacgc tctggcaact gggaatgcag aatatctggg
atggctggtc 3000gtggatgacg agctggtcgt ggatacatct aagattgcca
ctgaccaggt caaagcagtg 3060gaggccgaac tggggactat ccgccgatgg
cgggtggatg gattcttttc cccctctaaa 3120ctgagactga ggcctctgca
gatgtccaag gaggggatca agaaagagtc cgctcccgaa 3180ctgtctaaaa
tcattgacag accaggatgg ctgcccgccg tgaacaagct gttctctgat
3240ggaaatgtca ccgtcgtgcg gagagactct ctgggacgcg tgcgactgga
gagtacagcc 3300cacctgcctg tcacttggaa ggtgcagtaa gaattc
3336161175RNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 161nnnnnnnnnn nnnnnnnnnn guuucagugc
uauaggaaac uauaggaaau caccuucggg 60ugagcugaaa uccccuaaag cuaagauuga
auccggccac uaucuauuag uagauauccg 120gauauucuga uauaaaaccu
cauucuuuga uuagaccaaa ggaugagguu uuuuu 1751621422PRTSutterella
wadsworthensis 162Met Thr Gln Ser Glu Arg Arg Phe Ser Cys Ser Ile
Gly Ile Asp Met 1 5 10 15 Gly Ala Lys Tyr Thr Gly Val Phe Tyr Ala
Leu Phe Asp Arg Glu Glu 20 25 30 Leu Pro Thr Asn Leu Asn Ser Lys
Ala Met Thr Leu Val Met Pro Glu 35 40 45 Thr Gly Pro Arg Tyr Val
Gln Ala Gln Arg Thr Ala Val Arg His Arg 50 55 60 Leu Arg Gly Gln
Lys Arg Tyr Thr Leu Ala Arg Lys Leu Ala Phe Leu 65 70 75 80 Val Val
Asp Asp Met Ile Lys Lys Gln Glu Lys Arg Leu Thr Asp Glu 85 90 95
Glu Trp Lys Arg Gly Arg Glu Ala Leu Ser Gly Leu Leu Lys Arg Arg 100
105 110 Gly Tyr Ser Arg Pro Asn Ala Asp Gly Glu Asp Leu Thr Pro Leu
Glu 115 120 125 Asn Val Arg Ala Asp Val Phe Ala Ala His Pro Ala Phe
Ser Thr Tyr 130 135 140 Phe Ser Glu Val Arg Ser Leu Ala Glu Gln Trp
Glu Glu Phe Thr Ala 145 150 155 160 Asn Ile Ser Asn Val Glu Lys Phe
Leu Gly Asp Pro Asn Ile Pro Ala 165 170 175 Asp Lys Glu Phe Ile Glu
Phe Ala Val Ala Glu Gly Leu Ile Asp Lys 180 185 190 Thr Glu Lys Lys
Ala Tyr Gln Ser Ala Leu Ser Thr Leu Arg Ala Asn 195 200 205 Ala Asn
Val Leu Thr Gly Leu Arg Gln Met Gly His Lys Pro Arg Ser 210 215 220
Glu Tyr Phe Lys Ala Ile Glu Ala Asp Leu Lys Lys Asp Ser Arg Leu 225
230 235 240 Ala Lys Ile Asn Glu Ala Phe Gly Gly Ala Glu Arg Leu Ala
Arg Leu 245 250 255 Leu Gly Asn Leu Ser Asn Leu Gln Leu Arg Ala Glu
Arg Trp Tyr Phe 260 265 270 Asn Ala Pro Asp Ile Met Lys Asp Arg Gly
Trp Glu Pro Asp Arg Phe 275 280 285 Lys Lys Thr Leu Val Arg Ala Phe
Lys Phe Phe His Pro Ala Lys Asp 290 295 300 Gln Asn Lys Gln His Leu
Glu Leu Ile Lys Gln Ile Glu Asn Ser Glu 305 310 315 320 Asp Ile Ile
Glu Thr Leu Cys Thr Leu Asp Pro Asn Arg Thr Ile Pro 325 330 335 Pro
Tyr Glu Asp Gln Asn Asn Arg Arg Pro Pro Leu Asp Gln Thr Leu 340 345
350 Leu Leu Ser Pro Glu Lys Leu Thr Arg Gln Tyr Gly Glu Ile Trp Lys
355 360 365 Thr Trp Ser Ala Arg Leu Thr Ser Ala Glu Pro Thr Leu Ala
Pro Ala 370 375 380 Ala Glu Ile Leu Glu Arg Ser Thr Asp Arg Lys Ser
Arg Val Ala Val 385 390 395 400 Asn Gly His Glu Pro Leu Pro Thr Leu
Ala Tyr Gln Leu Ser Tyr Ala 405 410 415 Leu Gln Arg Ala Phe Asp Arg
Ser Lys Ala Leu Asp Pro Tyr Ala Leu 420 425 430 Arg Ala Leu Ala Ala
Gly Ser Lys Ser Asn Lys Leu Thr Ser Ala Arg 435 440 445 Thr Ala Leu
Glu Asn Cys Ile Gly Gly Gln Asn Val Lys Thr Phe Leu 450 455 460 Asp
Cys Ala Arg Arg Tyr Tyr Arg Glu Ala Asp Asp Ala Lys Val Gly 465 470
475 480 Leu Trp Phe Asp Asn Ala Asp Gly Leu Leu Glu Arg Ser Asp Leu
His 485 490 495 Pro Pro Met Lys Lys Lys Ile Leu Pro Leu Leu Val Ala
Asn Ile Leu 500 505 510 Gln Thr Asp Glu Thr Thr Gly Gln Lys Phe Leu
Asp Glu Ile Trp Arg 515 520 525 Lys Gln Ile Lys Gly Arg Glu Thr Val
Ala Ser Arg Cys Ala Arg Ile 530 535 540 Glu Thr Val Arg Lys Ser Phe
Gly Gly Gly Phe Asn Ile Ala Tyr Asn 545 550 555 560 Thr Ala Gln Tyr
Arg Glu Val Asn Lys Leu Pro Arg Asn Ala Gln Asp 565 570 575 Lys Glu
Leu Leu Thr Ile Arg Asp Arg Val Ala Glu Thr Ala Asp Phe 580 585 590
Ile Ala Ala Asn Leu Gly Leu Ser Asp Glu Gln Lys Arg Lys Phe Ala 595
600 605 Asn Pro Phe Ser Leu Ala Gln Phe Tyr Thr Leu Ile Glu Thr Glu
Val 610 615 620 Ser Gly Phe Ser Ala Thr Thr Leu Ala Val His Leu Glu
Asn Ala Trp 625 630 635 640 Arg Met Thr Ile Lys Asp Ala Val Ile Asn
Gly Glu Thr Val Arg Ala 645 650 655 Ala Gln Cys Ser Arg Leu Pro Ala
Glu Thr Ala Arg Pro Phe Asp Gly 660 665 670 Leu Val Arg Arg Leu Val
Asp Arg Gln Ala Trp Glu Ile Ala Lys Arg 675 680 685 Val Ser Thr Asp
Ile Gln Ser Lys Val Asp Phe Ser Asn Gly Ile Val 690 695 700 Asp Val
Ser Ile Phe Val Glu Glu Asn Lys Phe Glu Phe Ser Ala Ser 705 710 715
720 Val Ala Asp Leu Lys Lys Asn Lys Arg Val Lys Asp Lys Met Leu Ser
725 730 735 Glu Ala Glu Lys Leu Glu Thr Arg Trp Leu Ile Lys Asn Glu
Arg Ile 740 745 750 Lys Lys Ala Ser Arg Gly Thr Cys Pro Tyr Thr Gly
Asp Arg Leu Ala 755 760 765 Glu Gly Gly Glu Ile Asp His Ile Leu Pro
Arg Ser Leu Ile Lys Asp 770 775 780 Ala Arg Gly Ile Val Phe Asn Ala
Glu Pro Asn Leu Ile Tyr Ala Ser 785 790 795 800 Ser Arg Gly Asn Gln
Leu Lys Lys Asn Gln Arg Tyr Ser Leu Ser Asp 805 810 815 Leu Lys Ala
Asn Tyr Arg Asn Glu Ile Phe Lys Thr Ser Asn Ile Ala 820 825 830 Ala
Ile Thr Ala Glu Ile Glu Asp Val Val Thr Lys Leu Gln Gln Thr 835 840
845 His Arg Leu Lys Phe Phe Asp Leu Leu Asn Glu His Glu Gln Asp Cys
850 855 860 Val Arg His Ala Leu Phe Leu Asp Asp Gly Ser Glu Ala Arg
Asp Ala 865 870 875 880 Val Leu Glu Leu Leu Ala Thr Gln Arg Arg Thr
Arg Val Asn Gly Thr 885 890 895 Gln Ile Trp Met Ile Lys Asn Leu Ala
Asn Lys Ile Arg Glu Glu Leu 900 905 910 Gln Asn Trp Cys Lys Thr Thr
Asn Asn Arg Leu His Phe Gln Ala Ala 915 920 925 Ala Thr Asn Val Ser
Asp Ala Lys Asn Leu Arg Leu Lys Leu Ala Gln 930 935 940 Asn Gln Pro
Asp Phe Glu Lys Pro Asp Ile Gln Pro Ile Ala Ser His 945 950 955 960
Ser Ile Asp Ala Leu Cys Ser Phe Ala Val Gly Ser Ala Asp Ala Glu 965
970 975 Arg Asp Gln Asn Gly Phe Asp Tyr Leu Asp Gly Lys Thr Val Leu
Gly 980 985 990 Leu Tyr Pro Gln Ser Cys Glu Val Ile His Leu Gln Ala
Lys Pro Gln 995 1000 1005 Glu Glu Lys Ser His Phe Asp Ser Val Ala
Ile Phe Lys Glu Gly 1010 1015 1020
Ile Tyr Ala Glu Gln Phe Leu Pro Ile Phe Thr Leu Asn Glu Lys 1025
1030 1035 Ile Trp Ile Gly Tyr Glu Thr Leu Asn Ala Lys Gly Glu Arg
Cys 1040 1045 1050 Gly Ala Ile Glu Val Ser Gly Lys Gln Pro Lys Glu
Leu Leu Glu 1055 1060 1065 Met Leu Ala Pro Phe Phe Asn Lys Pro Val
Gly Asp Leu Ser Ala 1070 1075 1080 His Ala Thr Tyr Arg Ile Leu Lys
Lys Pro Ala Tyr Glu Phe Leu 1085 1090 1095 Ala Lys Ala Ala Leu Gln
Pro Leu Ser Ala Glu Glu Lys Arg Leu 1100 1105 1110 Ala Ala Leu Leu
Asp Ala Leu Arg Tyr Cys Thr Ser Arg Lys Ser 1115 1120 1125 Leu Met
Ser Leu Phe Met Ala Ala Asn Gly Lys Ser Leu Lys Lys 1130 1135 1140
Arg Glu Asp Val Leu Lys Pro Lys Leu Phe Gln Leu Lys Val Glu 1145
1150 1155 Leu Lys Gly Glu Lys Ser Phe Lys Leu Asn Gly Ser Leu Thr
Leu 1160 1165 1170 Pro Val Lys Gln Asp Trp Leu Arg Ile Cys Asp Ser
Pro Glu Leu 1175 1180 1185 Ala Asp Ala Phe Gly Lys Pro Cys Ser Ala
Asp Glu Leu Thr Ser 1190 1195 1200 Lys Leu Ala Arg Ile Trp Lys Arg
Pro Val Met Arg Asp Leu Ala 1205 1210 1215 His Ala Pro Val Arg Arg
Glu Phe Ser Leu Pro Ala Ile Asp Asn 1220 1225 1230 Pro Ser Gly Gly
Phe Arg Ile Arg Arg Thr Asn Leu Phe Gly Asn 1235 1240 1245 Glu Leu
Tyr Gln Val His Ala Ile Asn Ala Lys Lys Tyr Arg Gly 1250 1255 1260
Phe Ala Ser Ala Gly Ser Asn Val Asp Trp Ser Lys Gly Ile Leu 1265
1270 1275 Phe Asn Glu Leu Gln His Glu Asn Leu Thr Glu Cys Gly Gly
Arg 1280 1285 1290 Phe Ile Thr Ser Ala Asp Val Thr Pro Met Ser Glu
Trp Arg Lys 1295 1300 1305 Val Val Ala Glu Asp Asn Leu Ser Ile Trp
Ile Ala Pro Gly Thr 1310 1315 1320 Glu Gly Arg Arg Tyr Val Arg Val
Glu Thr Thr Phe Ile Gln Ala 1325 1330 1335 Ser His Trp Phe Glu Gln
Ser Val Glu Asn Trp Ala Ile Thr Ser 1340 1345 1350 Pro Leu Ser Leu
Pro Ala Ser Phe Lys Val Asp Lys Pro Ala Glu 1355 1360 1365 Phe Gln
Lys Ala Val Gly Thr Glu Leu Ser Glu Leu Leu Gly Gln 1370 1375 1380
Pro Arg Ser Glu Ile Phe Ile Glu Asn Val Gly Asn Ala Lys His 1385
1390 1395 Ile Arg Phe Trp Tyr Ile Val Val Ser Ser Asn Lys Lys Met
Asn 1400 1405 1410 Glu Ser Tyr Asn Asn Val Ser Lys Ser 1415 1420
1634350DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 163accggtgcca ccatgtaccc atacgatgtt
ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag cgtccatgac tcagagcgag
cgacgatttt cttgcagcat tggcattgac 120atgggggcta agtacactgg
ggtgttctac gcactgttcg accgggagga actgcccaca 180aacctgaaca
gcaaggccat gaccctggtc atgcctgaga cagggccaag atacgtgcag
240gcacagagaa ctgccgtcag acacaggctg cgcggacaga agagatatac
cctggctagg 300aaactggcat ttctggtggt cgacgatatg atcaagaaac
aggaaaagag gctgactgat 360gaggaatgga aacgaggacg ggaggccctg
tccggcctgc tgaagcggag agggtactct 420cggcccaacg ctgacggcga
agatctgacc cctctggaga atgtgagagc agacgtgttc 480gccgctcatc
ctgccttcag cacatatttt tccgaagtgc gctctctggc tgagcagtgg
540gaggagttca ccgcaaacat cagcaatgtc gagaagtttc tgggcgaccc
aaacatcccc 600gccgataaag agttcattga atttgccgtg gctgaagggc
tgattgacaa gaccgagaag 660aaagcctacc agtcagctct gagcaccctg
agggcaaacg ccaatgtgct gacaggactg 720cggcagatgg gccacaagcc
tagatcagaa tattttaaag caatcgaggc cgacctgaag 780aaagatagcc
gcctggccaa gattaacgaa gcattcggag gagcagagcg cctggctcga
840ctgctgggaa acctgtccaa tctgcagctg cgggcagaaa gatggtactt
caatgccccc 900gacatcatga aggatagggg ctgggagcct gatcgcttca
agaaaacact ggtgcgggct 960tttaagttct ttcacccagc aaaggaccag
aacaaacagc atctggaact gatcaaacag 1020attgagaaca gcgaagatat
cattgagact ctgtgcaccc tggacccaaa cagaaccatc 1080cccccttacg
aggatcagaa caataggcgc ccacccctgg accagactct gctgctgagt
1140cccgaaaagc tgacccggca gtatggcgag atctggaaaa catggagcgc
cagactgacc 1200tccgctgaac ccacactggc acctgcagcc gagattctgg
aaagatctac cgacaggaag 1260agtcgcgtgg cagtcaacgg acacgagcca
ctgcctacac tggcttacca gctgagttat 1320gcactgcaga gagccttcga
caggtcaaaa gccctggatc catatgctct gagggcactg 1380gctgcaggct
caaaaagcaa taagctgaca tccgcccgca ctgctctgga gaactgcatc
1440ggaggccaga atgtgaaaac cttcctggac tgtgcccgac ggtactatcg
ggaagcagac 1500gatgccaaag tcgggctgtg gttcgacaac gccgatggac
tgctggagag atctgacctg 1560catcctccaa tgaagaaaaa gatcctgccc
ctgctggtgg ccaatattct gcagacagat 1620gaaaccacag gccagaagtt
tctggacgag atctggcgaa aacagattaa ggggcgggaa 1680actgtggcta
gccgatgtgc acggatcgag acagtgcgga aatccttcgg gggaggcttt
1740aacattgcct acaataccgc tcagtatagg gaggtgaaca agctgccccg
caatgcccag 1800gataaagaac tgctgacaat cagagatagg gtggctgaga
ctgcagactt cattgccgct 1860aacctggggc tgtctgacga gcagaaaaga
aagttcgcca atccttttag tctggctcag 1920ttctacaccc tgatcgagac
agaagtgtcc ggattttctg caactaccct ggccgtccac 1980ctggagaacg
cctggaggat gacaatcaag gatgctgtga ttaatgggga aactgtcaga
2040gcagcacagt gcagcaggct gcctgcagag acagctcgcc cattcgatgg
actggtgaga 2100aggctggtcg acagacaggc ttgggagatc gcaaagaggg
tgtcaactga cattcagagc 2160aaagtcgatt tctccaacgg catcgtggac
gtcagcattt ttgtggagga aaataagttc 2220gagttttccg catctgtggc
cgatctgaaa aagaacaaac gggtcaaaga caagatgctg 2280tccgaggccg
aaaagctgga aaccagatgg ctgatcaaaa atgagcggat caagaaggcc
2340agccggggaa cttgtcccta caccggcgat aggctggctg aggggggaga
aatcgaccac 2400attctgcccc gaagcctgat caaggatgcc cggggaattg
tgtttaacgc tgagcctaat 2460ctgatctatg caagctcccg cggcaaccag
ctgaaaaaga atcagcgata cagtctgtca 2520gatctgaagg ccaactatcg
gaatgagatc ttcaaaacta gcaacatcgc tgcaattacc 2580gccgagattg
aggacgtggt cactaagctg cagcagaccc atagactgaa attctttgat
2640ctgctgaatg agcacgaaca ggactgcgtg cggcacgccc tgttcctgga
cgatggcagc 2700gaagctcgcg acgcagtgct ggagctgctg gcaacacagc
gccgaactcg cgtcaacggg 2760acacagatct ggatgattaa gaacctggcc
aacaagatcc gagaggaact gcagaattgg 2820tgtaagacaa ctaacaatag
actgcacttt caggccgctg caactaacgt gtccgatgca 2880aagaatctga
ggctgaaact ggcccagaac cagcccgact tcgagaagcc agatatccag
2940cccattgcca gccattccat cgacgccctg tgctctttcg ctgtggggag
tgctgacgca 3000gaacgcgatc agaatggatt tgactacctg gatggcaaga
ccgtgctggg actgtatcca 3060cagagctgtg aggtcattca cctgcaggcc
aagccccagg aggaaaaaag tcatttcgat 3120tcagtggcta tctttaagga
aggcatctac gcagagcagt tcctgcctat ctttaccctg 3180aacgaaaaga
tctggattgg atatgagaca ctgaatgcca aaggcgaaag atgcggggct
3240attgaggtga gtggcaaaca gccaaaggag ctgctggaaa tgctggcccc
cttctttaac 3300aagcctgtgg gcgacctgtc agcccacgct acttaccgga
tcctgaaaaa gcctgcatat 3360gagtttctgg caaaggcagc tctgcagcca
ctgagcgcag aggaaaaaag actggcagcc 3420ctgctggatg ctctgcgcta
ctgtaccagt cgaaagtcac tgatgagcct gttcatggct 3480gcaaacggga
aatccctgaa aaagcgggag gacgtgctga aacccaagct gttccagctg
3540aaggtcgagc tgaaaggcga aaagagcttc aagctgaacg ggagcctgac
cctgcctgtg 3600aagcaggact ggctgagaat ctgcgatagc ccagaactgg
cagacgcctt tggcaaaccc 3660tgttccgccg atgagctgac atctaagctg
gctcgcattt ggaaacgacc tgtgatgcgg 3720gatctggctc atgcaccagt
ccggagagag ttcagcctgc ccgcaatcga caacccaagt 3780ggagggttca
ggattaggcg caccaacctg tttggcaatg agctgtacca ggtgcacgcc
3840atcaacgcta aaaagtatcg cggcttcgcc tccgctgggt ctaatgtcga
ctggtccaag 3900gggatcctgt ttaacgagct gcagcatgaa aatctgaccg
agtgcggagg caggttcatt 3960acaagcgccg atgtgactcc tatgtccgaa
tggcgcaagg tggtcgcaga ggacaacctg 4020tctatctgga ttgctccagg
gacagaagga cgacggtacg tgagggtcga gacaacattc 4080atccaggcca
gtcactggtt tgaacagtca gtggagaatt gggccattac tagtcctctg
4140tcactgccag cttccttcaa ggtggacaaa ccagctgagt ttcagaaggc
agtcggaacc 4200gagctgtcag aactgctggg ccagcccagg agcgaaatct
tcattgagaa cgtgggcaat 4260gccaagcata tccgcttttg gtacattgtg
gtgagcagca acaaaaagat gaacgagtct 4320tacaacaatg tgtctaagag
ttaagaattc 4350164112RNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotide 164nnnnnnnnnn
nnnnnnnnnn guuucagugg ugaaaacccu gaaaucaaca aaauuaaaga 60uugaaucguu
uuucuaugcu cgucuuaaua gcgagcauau aacgauuuuu uu
1121651372PRTLegionella pneumophila 165Met Glu Ser Ser Gln Ile Leu
Ser Pro Ile Gly Ile Asp Leu Gly Gly 1 5 10 15 Lys Phe Thr Gly Val
Cys Leu Ser His Leu Glu Ala Phe Ala Glu Leu 20 25 30 Pro Asn His
Ala Asn Thr Lys Tyr Ser Val Ile Leu Ile Asp His Asn 35 40 45 Asn
Phe Gln Leu Ser Gln Ala Gln Arg Arg Ala Thr Arg His Arg Val 50 55
60 Arg Asn Lys Lys Arg Asn Gln Phe Val Lys Arg Val Ala Leu Gln Leu
65 70 75 80 Phe Gln His Ile Leu Ser Arg Asp Leu Asn Ala Lys Glu Glu
Thr Ala 85 90 95 Leu Cys His Tyr Leu Asn Asn Arg Gly Tyr Thr Tyr
Val Asp Thr Asp 100 105 110 Leu Asp Glu Tyr Ile Lys Asp Glu Thr Thr
Ile Asn Leu Leu Lys Glu 115 120 125 Leu Leu Pro Ser Glu Ser Glu His
Asn Phe Ile Asp Trp Phe Leu Gln 130 135 140 Lys Met Gln Ser Ser Glu
Phe Arg Lys Ile Leu Val Ser Lys Val Glu 145 150 155 160 Glu Lys Lys
Asp Asp Lys Glu Leu Lys Asn Ala Val Lys Asn Ile Lys 165 170 175 Asn
Phe Ile Thr Gly Phe Glu Lys Asn Ser Val Glu Gly His Arg His 180 185
190 Arg Lys Val Tyr Phe Glu Asn Ile Lys Ser Asp Ile Thr Lys Asp Asn
195 200 205 Gln Leu Asp Ser Ile Lys Lys Lys Ile Pro Ser Val Cys Leu
Ser Asn 210 215 220 Leu Leu Gly His Leu Ser Asn Leu Gln Trp Lys Asn
Leu His Arg Tyr 225 230 235 240 Leu Ala Lys Asn Pro Lys Gln Phe Asp
Glu Gln Thr Phe Gly Asn Glu 245 250 255 Phe Leu Arg Met Leu Lys Asn
Phe Arg His Leu Lys Gly Ser Gln Glu 260 265 270 Ser Leu Ala Val Arg
Asn Leu Ile Gln Gln Leu Glu Gln Ser Gln Asp 275 280 285 Tyr Ile Ser
Ile Leu Glu Lys Thr Pro Pro Glu Ile Thr Ile Pro Pro 290 295 300 Tyr
Glu Ala Arg Thr Asn Thr Gly Met Glu Lys Asp Gln Ser Leu Leu 305 310
315 320 Leu Asn Pro Glu Lys Leu Asn Asn Leu Tyr Pro Asn Trp Arg Asn
Leu 325 330 335 Ile Pro Gly Ile Ile Asp Ala His Pro Phe Leu Glu Lys
Asp Leu Glu 340 345 350 His Thr Lys Leu Arg Asp Arg Lys Arg Ile Ile
Ser Pro Ser Lys Gln 355 360 365 Asp Glu Lys Arg Asp Ser Tyr Ile Leu
Gln Arg Tyr Leu Asp Leu Asn 370 375 380 Lys Lys Ile Asp Lys Phe Lys
Ile Lys Lys Gln Leu Ser Phe Leu Gly 385 390 395 400 Gln Gly Lys Gln
Leu Pro Ala Asn Leu Ile Glu Thr Gln Lys Glu Met 405 410 415 Glu Thr
His Phe Asn Ser Ser Leu Val Ser Val Leu Ile Gln Ile Ala 420 425 430
Ser Ala Tyr Asn Lys Glu Arg Glu Asp Ala Ala Gln Gly Ile Trp Phe 435
440 445 Asp Asn Ala Phe Ser Leu Cys Glu Leu Ser Asn Ile Asn Pro Pro
Arg 450 455 460 Lys Gln Lys Ile Leu Pro Leu Leu Val Gly Ala Ile Leu
Ser Glu Asp 465 470 475 480 Phe Ile Asn Asn Lys Asp Lys Trp Ala Lys
Phe Lys Ile Phe Trp Asn 485 490 495 Thr His Lys Ile Gly Arg Thr Ser
Leu Lys Ser Lys Cys Lys Glu Ile 500 505 510 Glu Glu Ala Arg Lys Asn
Ser Gly Asn Ala Phe Lys Ile Asp Tyr Glu 515 520 525 Glu Ala Leu Asn
His Pro Glu His Ser Asn Asn Lys Ala Leu Ile Lys 530 535 540 Ile Ile
Gln Thr Ile Pro Asp Ile Ile Gln Ala Ile Gln Ser His Leu 545 550 555
560 Gly His Asn Asp Ser Gln Ala Leu Ile Tyr His Asn Pro Phe Ser Leu
565 570 575 Ser Gln Leu Tyr Thr Ile Leu Glu Thr Lys Arg Asp Gly Phe
His Lys 580 585 590 Asn Cys Val Ala Val Thr Cys Glu Asn Tyr Trp Arg
Ser Gln Lys Thr 595 600 605 Glu Ile Asp Pro Glu Ile Ser Tyr Ala Ser
Arg Leu Pro Ala Asp Ser 610 615 620 Val Arg Pro Phe Asp Gly Val Leu
Ala Arg Met Met Gln Arg Leu Ala 625 630 635 640 Tyr Glu Ile Ala Met
Ala Lys Trp Glu Gln Ile Lys His Ile Pro Asp 645 650 655 Asn Ser Ser
Leu Leu Ile Pro Ile Tyr Leu Glu Gln Asn Arg Phe Glu 660 665 670 Phe
Glu Glu Ser Phe Lys Lys Ile Lys Gly Ser Ser Ser Asp Lys Thr 675 680
685 Leu Glu Gln Ala Ile Glu Lys Gln Asn Ile Gln Trp Glu Glu Lys Phe
690 695 700 Gln Arg Ile Ile Asn Ala Ser Met Asn Ile Cys Pro Tyr Lys
Gly Ala 705 710 715 720 Ser Ile Gly Gly Gln Gly Glu Ile Asp His Ile
Tyr Pro Arg Ser Leu 725 730 735 Ser Lys Lys His Phe Gly Val Ile Phe
Asn Ser Glu Val Asn Leu Ile 740 745 750 Tyr Cys Ser Ser Gln Gly Asn
Arg Glu Lys Lys Glu Glu His Tyr Leu 755 760 765 Leu Glu His Leu Ser
Pro Leu Tyr Leu Lys His Gln Phe Gly Thr Asp 770 775 780 Asn Val Ser
Asp Ile Lys Asn Phe Ile Ser Gln Asn Val Ala Asn Ile 785 790 795 800
Lys Lys Tyr Ile Ser Phe His Leu Leu Thr Pro Glu Gln Gln Lys Ala 805
810 815 Ala Arg His Ala Leu Phe Leu Asp Tyr Asp Asp Glu Ala Phe Lys
Thr 820 825 830 Ile Thr Lys Phe Leu Met Ser Gln Gln Lys Ala Arg Val
Asn Gly Thr 835 840 845 Gln Lys Phe Leu Gly Lys Gln Ile Met Glu Phe
Leu Ser Thr Leu Ala 850 855 860 Asp Ser Lys Gln Leu Gln Leu Glu Phe
Ser Ile Lys Gln Ile Thr Ala 865 870 875 880 Glu Glu Val His Asp His
Arg Glu Leu Leu Ser Lys Gln Glu Pro Lys 885 890 895 Leu Val Lys Ser
Arg Gln Gln Ser Phe Pro Ser His Ala Ile Asp Ala 900 905 910 Thr Leu
Thr Met Ser Ile Gly Leu Lys Glu Phe Pro Gln Phe Ser Gln 915 920 925
Glu Leu Asp Asn Ser Trp Phe Ile Asn His Leu Met Pro Asp Glu Val 930
935 940 His Leu Asn Pro Val Arg Ser Lys Glu Lys Tyr Asn Lys Pro Asn
Ile 945 950 955 960 Ser Ser Thr Pro Leu Phe Lys Asp Ser Leu Tyr Ala
Glu Arg Phe Ile 965 970 975 Pro Val Trp Val Lys Gly Glu Thr Phe Ala
Ile Gly Phe Ser Glu Lys 980 985 990 Asp Leu Phe Glu Ile Lys Pro Ser
Asn Lys Glu Lys Leu Phe Thr Leu 995 1000 1005 Leu Lys Thr Tyr Ser
Thr Lys Asn Pro Gly Glu Ser Leu Gln Glu 1010 1015 1020 Leu Gln Ala
Lys Ser Lys Ala Lys Trp Leu Tyr Phe Pro Ile Asn 1025 1030 1035 Lys
Thr Leu Ala Leu Glu Phe Leu His His Tyr Phe His Lys Glu 1040 1045
1050 Ile Val Thr Pro Asp Asp Thr Thr Val Cys His Phe Ile Asn Ser
1055 1060 1065 Leu Arg Tyr Tyr Thr Lys Lys Glu Ser Ile Thr Val Lys
Ile Leu 1070 1075 1080 Lys Glu Pro Met Pro Val Leu Ser Val Lys Phe
Glu Ser Ser Lys 1085 1090 1095 Lys Asn Val Leu Gly Ser Phe Lys His
Thr Ile Ala Leu Pro Ala 1100 1105 1110 Thr Lys Asp Trp Glu Arg Leu
Phe Asn His Pro Asn Phe Leu Ala 1115 1120 1125 Leu Lys Ala Asn Pro
Ala Pro Asn Pro Lys Glu Phe Asn Glu Phe 1130 1135 1140 Ile Arg Lys
Tyr Phe Leu Ser Asp Asn Asn Pro Asn Ser Asp Ile 1145
1150 1155 Pro Asn Asn Gly His Asn Ile Lys Pro Gln Lys His Lys Ala
Val 1160 1165 1170 Arg Lys Val Phe Ser Leu Pro Val Ile Pro Gly Asn
Ala Gly Thr 1175 1180 1185 Met Met Arg Ile Arg Arg Lys Asp Asn Lys
Gly Gln Pro Leu Tyr 1190 1195 1200 Gln Leu Gln Thr Ile Asp Asp Thr
Pro Ser Met Gly Ile Gln Ile 1205 1210 1215 Asn Glu Asp Arg Leu Val
Lys Gln Glu Val Leu Met Asp Ala Tyr 1220 1225 1230 Lys Thr Arg Asn
Leu Ser Thr Ile Asp Gly Ile Asn Asn Ser Glu 1235 1240 1245 Gly Gln
Ala Tyr Ala Thr Phe Asp Asn Trp Leu Thr Leu Pro Val 1250 1255 1260
Ser Thr Phe Lys Pro Glu Ile Ile Lys Leu Glu Met Lys Pro His 1265
1270 1275 Ser Lys Thr Arg Arg Tyr Ile Arg Ile Thr Gln Ser Leu Ala
Asp 1280 1285 1290 Phe Ile Lys Thr Ile Asp Glu Ala Leu Met Ile Lys
Pro Ser Asp 1295 1300 1305 Ser Ile Asp Asp Pro Leu Asn Met Pro Asn
Glu Ile Val Cys Lys 1310 1315 1320 Asn Lys Leu Phe Gly Asn Glu Leu
Lys Pro Arg Asp Gly Lys Met 1325 1330 1335 Lys Ile Val Ser Thr Gly
Lys Ile Val Thr Tyr Glu Phe Glu Ser 1340 1345 1350 Asp Ser Thr Pro
Gln Trp Ile Gln Thr Leu Tyr Val Thr Gln Leu 1355 1360 1365 Lys Lys
Gln Pro 1370 1664200DNAArtificial SequenceDescription of Artificial
Sequence Synthetic polynucleotide 166accggtgcca ccatgtaccc
atacgatgtt ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag cgtccatgga
gtcctctcag atcctgtcac ctatcggcat cgacctgggc 120ggaaagttta
ctggagtctg cctgtcacac ctggaagcat ttgctgagct gcctaaccac
180gcaaatacaa agtactcagt gatcctgatt gatcataaca atttccagct
gagccaggca 240cagcggagag ccactagaca cagggtgcgc aacaagaaaa
gaaatcagtt cgtgaagagg 300gtcgccctgc agctgtttca gcacatcctg
tcccgggacc tgaacgccaa ggaggaaacc 360gctctgtgcc attacctgaa
caatagaggc tacacctatg tggacacaga tctggacgag 420tatatcaaag
atgaaaccac aattaacctg ctgaaggagc tgctgccaag cgagtccgaa
480cataatttca ttgactggtt tctgcagaag atgcagagct ccgagttccg
gaagatcctg 540gtgagcaaag tcgaggaaaa gaaagacgat aaagaactga
agaacgccgt gaagaacatc 600aagaacttca tcaccggatt cgagaaaaat
agcgtggaag gccaccgaca tcggaaggtc 660tactttgaga acatcaagtc
cgatattaca aaagacaatc agctggattc tatcaagaaa 720aagattccta
gcgtgtgtct gtccaacctg ctgggccacc tgtccaacct gcagtggaag
780aatctgcata ggtatctggc caaaaatcca aagcagttcg acgagcagac
cttcgggaac 840gaatttctgc ggatgctgaa gaattttcga cacctgaaag
gatctcagga gagtctggct 900gtgcgcaacc tgatccagca gctggaacag
tctcaggatt acatcagtat cctggagaaa 960accccccctg aaatcaccat
tccaccctat gaggcccgga caaacactgg catggaaaaa 1020gaccagagcc
tgctgctgaa ccccgagaag ctgaacaatc tgtacccaaa ctggagaaat
1080ctgatccccg ggatcattga cgcccaccct ttcctggaga aggatctgga
acatacaaag 1140ctgagagaca ggaaacgcat catttctccc agtaaacagg
acgagaagcg ggatagctac 1200atcctgcaga gatatctgga cctgaacaaa
aagatcgata agttcaagat caagaagcag 1260ctgagctttc tgggacaggg
caaacagctg cctgctaacc tgatcgagac acagaaggag 1320atggaaactc
acttcaattc tagtctggtg tctgtcctga tccagattgc tagtgcatac
1380aacaaggaga gggaagatgc cgctcagggg atctggttcg acaatgcctt
ttcactgtgc 1440gagctgagca acatcaatcc tccacgcaaa cagaagattc
tgcccctgct ggtgggagca 1500atcctgagcg aggacttcat taacaacaag
gataagtggg ccaaattcaa gatcttttgg 1560aacacccaca agattgggcg
aacatcactg aaaagcaagt gtaaagagat cgaggaagcc 1620cggaagaaca
gtggaaacgc ttttaaaatc gactacgagg aagctctgaa tcacccagag
1680cattcaaaca acaaggccct gatcaagatc attcagacca ttcccgatat
cattcaggcc 1740atccagtcac acctgggaca taacgacagc caggctctga
tctaccacaa tcctttctca 1800ctgagccagc tgtatactat cctggagaca
aagagggatg gctttcataa aaactgcgtg 1860gccgtcactt gtgaaaatta
ctggcggagc cagaaaaccg agatcgaccc agaaatttcc 1920tatgcatcta
ggctgccagc agacagtgtg cgccccttcg atggcgtcct ggcacgaatg
1980atgcagcggc tggcctacga gatcgccatg gctaagtggg aacagatcaa
acacattcct 2040gataactcaa gcctgctgat cccaatctac ctggagcaga
atcggttcga atttgaggag 2100agcttcaaga agatcaaggg gtcctctagt
gacaaaaccc tggagcaggc catcgaaaag 2160cagaacattc agtgggagga
aaagttccag agaatcatta acgcaagtat gaatatctgc 2220ccttacaagg
gcgcctcaat tggcgggcag ggggagatcg accacatcta cccaaggtcc
2280ctgtctaaaa agcatttcgg cgtgatcttt aactccgaag tcaatctgat
ctactgttca 2340agccagggga atcgcgagaa aaaggaggaa cactacctgc
tggaacatct gtctccactg 2400tatctgaaac accagttcgg cactgacaac
gtgtccgata tcaagaattt tatttctcag 2460aacgtcgcta atatcaaaaa
gtacatttcc ttccacctgc tgaccccaga gcagcagaag 2520gcagcacggc
acgccctgtt tctggattat gacgatgaag cattcaaaac cattacaaag
2580tttctgatgt ctcagcagaa ggccagagtg aacggcacac agaaattcct
ggggaagcag 2640atcatggagt ttctgtccac tctggcagat tctaaacagc
tgcagctgga gttcagcatc 2700aagcagatta ccgccgagga agtgcacgac
catagagagc tgctgtctaa gcaggaaccc 2760aaactggtca agagtaggca
gcagagtttc ccttcacacg ctatcgacgc aactctgacc 2820atgtctattg
ggctgaagga gttcccacag tttagtcagg aactggataa ctcatggttt
2880atcaatcacc tgatgccaga cgaggtgcat ctgaaccccg tccggagcaa
ggaaaagtac 2940aacaaaccta acatctcctc tactccactg ttcaaggatt
ccctgtatgc tgagcggttc 3000atccccgtgt gggtcaaggg agaaaccttc
gcaatcggct ttagcgagaa ggacctgttc 3060gagatcaagc cctccaacaa
ggagaaactg tttacactgc tgaaaaccta cagtactaaa 3120aatcctggcg
agtcactgca ggaactgcag gctaagagca aagcaaagtg gctgtacttc
3180ccaatcaaca aaaccctggc cctggagttc ctgcaccatt attttcacaa
ggaaatcgtg 3240acacccgacg atactaccgt ctgccatttc atcaactcac
tgagatacta cactaaaaag 3300gagagcatca ccgtgaaaat tctgaaggaa
cccatgcctg tgctgtccgt caagttcgag 3360agttcaaaaa agaacgtgct
gggatctttt aaacacacaa tcgccctgcc tgctactaag 3420gattgggaga
ggctgttcaa ccatccaaat tttctggcac tgaaggccaa cccagctccc
3480aatcctaaag agttcaatga gttcatccgc aagtacttcc tgagcgacaa
caatcccaac 3540tccgatatcc ctaacaatgg ccacaatatc aagccccaga
aacataaggc cgtgcgaaag 3600gtctttagcc tgccagtgat ccccgggaac
gctggaacca tgatgcgcat taggcgcaaa 3660gacaataagg gacagccact
gtatcagctg cagacaatcg acgatactcc cagcatgggc 3720atccagatta
acgaggatcg cctggtgaaa caggaagtcc tgatggacgc ctacaagaca
3780cgaaatctga gcactatcga tgggattaac aattccgagg gacaggcata
tgccacattc 3840gacaactggc tgaccctgcc cgtgagcacc ttcaagcctg
agatcatcaa gctggaaatg 3900aagcctcact ctaaaacccg acggtacatc
agaattacac agagtctggc cgacttcatc 3960aaaactattg atgaggctct
gatgatcaag cccagtgact caattgacga tcctctgaac 4020atgccaaatg
agatcgtgtg taaaaacaag ctgttcggga atgaactgaa gcctagggat
4080ggaaaaatga agatcgtgag cactggcaag attgtcacct acgagtttga
aagcgactcc 4140accccccagt ggatccagac cctgtatgtg acacagctga
aaaagcagcc ttaagaattc 4200167127RNAArtificial SequenceDescription
of Artificial Sequence Synthetic polynucleotide 167nnnnnnnnnn
nnnnnnnnnn guuugagagu uggaaacaac gaguucaaau aagaauucau 60caaaaucguc
ccuuuuggga ccgcucauug uggagcauca aggcuuaaca ugguuaagcc 120uuuuuuu
1271681395PRTTreponema denticola 168Met Lys Lys Glu Ile Lys Asp Tyr
Phe Leu Gly Leu Asp Val Gly Thr 1 5 10 15 Gly Ser Val Gly Trp Ala
Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 20 25 30 Ala Asn Arg Lys
Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 35 40 45 Thr Ala
Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 50 55 60
Arg Arg Lys Lys Arg Ile Lys Leu Leu Gln Glu Leu Phe Ser Gln Glu 65
70 75 80 Ile Ala Lys Thr Asp Glu Gly Phe Phe Gln Arg Met Lys Glu
Ser Pro 85 90 95 Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gln Glu Asn
Thr Leu Phe Asn 100 105 110 Asp Lys Asp Phe Ala Asp Lys Thr Tyr His
Lys Ala Tyr Pro Thr Ile 115 120 125 Asn His Leu Ile Lys Ala Trp Ile
Glu Asn Lys Val Lys Pro Asp Pro 130 135 140 Arg Leu Leu Tyr Leu Ala
Cys His Asn Ile Ile Lys Lys Arg Gly His 145 150 155 160 Phe Leu Phe
Glu Gly Asp Phe Asp Ser Glu Asn Gln Phe Asp Thr Ser 165 170 175 Ile
Gln Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 180 185
190 Asp Ala Asp Ser Gln Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu
195 200 205 Lys Asn Ser Glu Lys Gln Ser Arg Leu Asn Lys Ile Leu Gly
Leu Lys 210 215 220 Pro Ser Asp Lys Gln Lys Lys Ala Ile Thr Asn Leu
Ile Ser Gly Asn 225 230 235 240 Lys Ile Asn Phe Ala Asp Leu Tyr Asp
Asn Pro Asp Leu Lys Asp Ala 245 250 255 Glu Lys Asn Ser Ile Ser Phe
Ser Lys Asp Asp Phe Asp Ala Leu Ser 260 265 270 Asp Asp Leu Ala Ser
Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 275 280 285 Ala Lys Ala
Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 290 295 300 Glu
Gln Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 305 310
315 320 Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro
Lys 325 330 335 Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys
Asn Asn Asn 340 345 350 Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr
Lys Ser Lys Lys Leu 355 360 365 Ile Ile Asn Asn Ser Val Asn Gln Glu
Asp Phe Tyr Lys Phe Leu Lys 370 375 380 Thr Ile Leu Ser Ala Lys Ser
Glu Ile Lys Glu Val Asn Asp Ile Leu 385 390 395 400 Thr Glu Ile Glu
Thr Gly Thr Phe Leu Pro Lys Gln Ile Ser Lys Ser 405 410 415 Asn Ala
Glu Ile Pro Tyr Gln Leu Arg Lys Met Glu Leu Glu Lys Ile 420 425 430
Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gln Lys Asp Glu 435
440 445 Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe
Lys 450 455 460 Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys
Lys Phe Phe 465 470 475 480 Pro Asp Arg Cys Trp Val Val Lys Lys Glu
Lys Ser Pro Ser Gly Lys 485 490 495 Thr Thr Pro Trp Asn Phe Phe Asp
His Ile Asp Lys Glu Lys Thr Ala 500 505 510 Glu Ala Phe Ile Thr Ser
Arg Thr Asn Phe Cys Thr Tyr Leu Val Gly 515 520 525 Glu Ser Val Leu
Pro Lys Ser Ser Leu Leu Tyr Ser Glu Tyr Thr Val 530 535 540 Leu Asn
Glu Ile Asn Asn Leu Gln Ile Ile Ile Asp Gly Lys Asn Ile 545 550 555
560 Cys Asp Ile Lys Leu Lys Gln Lys Ile Tyr Glu Asp Leu Phe Lys Lys
565 570 575 Tyr Lys Lys Ile Thr Gln Lys Gln Ile Ser Thr Phe Ile Lys
His Glu 580 585 590 Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu
Gly Ile Asp Lys 595 600 605 Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile
Glu Leu Lys Asn Ile Phe 610 615 620 Gly Lys Gln Val Asp Glu Ile Ser
Thr Lys Asn Met Leu Glu Glu Ile 625 630 635 640 Ile Arg Trp Ala Thr
Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 645 650 655 Lys Thr Lys
Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gln 660 665 670 Ile
Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 675 680
685 Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu
690 695 700 Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gln Asn Asn
Leu Met 705 710 715 720 Glu Leu Leu Ser Ser Glu Phe Thr Phe Thr Glu
Asn Ile Lys Lys Ile 725 730 735 Asn Ser Gly Phe Glu Asp Ala Glu Lys
Gln Phe Ser Tyr Asp Gly Leu 740 745 750 Val Lys Pro Leu Phe Leu Ser
Pro Ser Val Lys Lys Met Leu Trp Gln 755 760 765 Thr Leu Lys Leu Val
Lys Glu Ile Ser His Ile Thr Gln Ala Pro Pro 770 775 780 Lys Lys Ile
Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 785 790 795 800
Arg Thr Lys Thr Arg Leu Lys Ile Leu Gln Asp Leu Tyr Asn Asn Cys 805
810 815 Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Lys Asp Leu Ser
Gly 820 825 830 Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp
Lys Leu Tyr 835 840 845 Leu Tyr Tyr Thr Gln Leu Gly Lys Cys Met Tyr
Cys Gly Lys Pro Ile 850 855 860 Glu Ile Gly His Val Phe Asp Thr Ser
Asn Tyr Asp Ile Asp His Ile 865 870 875 880 Tyr Pro Gln Ser Lys Ile
Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 885 890 895 Val Cys Ser Ser
Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 900 905 910 Ser Glu
Ile Gln Ser Lys Gln Arg Gly Phe Trp Asn Phe Leu Gln Arg 915 920 925
Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Ala Thr 930
935 940 Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala Arg Gln Leu
Val 945 950 955 960 Glu Thr Arg Gln Ala Thr Lys Val Ala Ala Lys Val
Leu Glu Lys Met 965 970 975 Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys
Ala Glu Thr Val Ser Met 980 985 990 Phe Arg Asn Lys Phe Asp Ile Val
Lys Cys Arg Glu Ile Asn Asp Phe 995 1000 1005 His His Ala His Asp
Ala Tyr Leu Asn Ile Val Val Gly Asn Val 1010 1015 1020 Tyr Asn Thr
Lys Phe Thr Asn Asn Pro Trp Asn Phe Ile Lys Glu 1025 1030 1035 Lys
Arg Asp Asn Pro Lys Ile Ala Asp Thr Tyr Asn Tyr Tyr Lys 1040 1045
1050 Val Phe Asp Tyr Asp Val Lys Arg Asn Asn Ile Thr Ala Trp Glu
1055 1060 1065 Lys Gly Lys Thr Ile Ile Thr Val Lys Asp Met Leu Lys
Arg Asn 1070 1075 1080 Thr Pro Ile Tyr Thr Arg Gln Ala Ala Cys Lys
Lys Gly Glu Leu 1085 1090 1095 Phe Asn Gln Thr Ile Met Lys Lys Gly
Leu Gly Gln His Pro Leu 1100 1105 1110 Lys Lys Glu Gly Pro Phe Ser
Asn Ile Ser Lys Tyr Gly Gly Tyr 1115 1120 1125 Asn Lys Val Ser Ala
Ala Tyr Tyr Thr Leu Ile Glu Tyr Glu Glu 1130 1135 1140 Lys Gly Asn
Lys Ile Arg Ser Leu Glu Thr Ile Pro Leu Tyr Leu 1145 1150 1155 Val
Lys Asp Ile Gln Lys Asp Gln Asp Val Leu Lys Ser Tyr Leu 1160 1165
1170 Thr Asp Leu Leu Gly Lys Lys Glu Phe Lys Ile Leu Val Pro Lys
1175 1180 1185 Ile Lys Ile Asn Ser Leu Leu Lys Ile Asn Gly Phe Pro
Cys His 1190 1195 1200 Ile Thr Gly Lys Thr Asn Asp Ser Phe Leu Leu
Arg Pro Ala Val 1205 1210 1215 Gln Phe Cys Cys Ser Asn Asn Glu Val
Leu Tyr Phe Lys Lys Ile 1220 1225 1230 Ile Arg Phe Ser Glu Ile Arg
Ser Gln Arg Glu Lys Ile Gly Lys 1235 1240 1245 Thr Ile Ser Pro Tyr
Glu Asp Leu Ser Phe Arg Ser Tyr Ile Lys 1250 1255 1260 Glu Asn Leu
Trp Lys Lys Thr Lys Asn Asp Glu Ile Gly Glu Lys 1265 1270 1275 Glu
Phe Tyr Asp Leu Leu Gln Lys Lys Asn Leu Glu Ile Tyr Asp 1280 1285
1290 Met Leu Leu Thr Lys His Lys Asp Thr Ile Tyr Lys Lys Arg Pro
1295 1300 1305 Asn Ser Ala Thr Ile Asp Ile Leu Val Lys Gly Lys Glu
Lys Phe 1310 1315 1320 Lys Ser Leu Ile Ile Glu Asn Gln Phe Glu Val
Ile Leu Glu Ile 1325 1330 1335 Leu Lys Leu Phe Ser Ala Thr Arg Asn
Val Ser Asp
Leu Gln His 1340 1345 1350 Ile Gly Gly Ser Lys Tyr Ser Gly Val Ala
Lys Ile Gly Asn Lys 1355 1360 1365 Ile Ser Ser Leu Asp Asn Cys Ile
Leu Ile Tyr Gln Ser Ile Thr 1370 1375 1380 Gly Ile Phe Glu Lys Arg
Ile Asp Leu Leu Lys Val 1385 1390 1395 1694269DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
169accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtccatgaa aaaagaaatc aaagactact tcctggggct
ggatgtgggg 120actgggagcg tggggtgggc tgtgaccgat actgactaca
aactgctgaa ggctaaccga 180aaagacctgt ggggcatgag atgcttcgag
acagccgaaa ctgctgaggt gcggagactg 240cacaggggag ccaggcgccg
aatcgagcgg agaaagaaac gcattaagct gctgcaggag 300ctgttctctc
aggaaatcgc caaaaccgat gagggcttct ttcagagaat gaaggaaagc
360cccttttacg ctgaggacaa aacaatcctg caggaaaaca ctctgttcaa
tgacaaggat 420tttgctgata agacttacca caaagcatat cctaccatta
atcatctgat caaggcttgg 480attgagaaca aggtgaaacc agacccccga
ctgctgtacc tggcatgtca caacatcatt 540aagaaaaggg gacatttcct
gtttgaaggc gacttcgatt cagagaatca gtttgatacc 600agcatccagg
cactgttcga gtatctgcgc gaggacatgg aggtggacat cgatgccgac
660agccagaagg tcaaagagat tctgaaggat agctccctga agaactctga
aaaacagagt 720cggctgaata agatcctggg gctgaagcct tccgacaaac
agaagaaagc catcacaaac 780ctgatttctg gaaacaagat caatttcgcc
gatctgtacg acaatccaga tctgaaggac 840gctgagaaaa actcaatcag
cttctccaag gacgattttg atgcactgag tgacgatctg 900gcctcaattc
tgggcgacag ctttgaactg ctgctgaagg ccaaagctgt ctataactgc
960tctgtgctga gtaaggtcat cggggacgag cagtacctga gcttcgccaa
ggtgaaaatc 1020tacgaaaagc acaaaaccga tctgacaaag ctgaaaaacg
tgatcaagaa acatttcccc 1080aaggactaca agaaggtctt tggatacaac
aagaacgaga aaaacaacaa caattactcc 1140ggctatgtgg gagtctgtaa
gaccaagagt aagaaactga tcattaacaa ctcagtcaac 1200caggaagatt
tctacaagtt tctgaaaact atcctgtcag ccaagagcga gatcaaggaa
1260gtgaatgaca tcctgaccga gattgaaact ggcacctttc tgccaaagca
gatctctaaa 1320agtaacgcag agattcccta tcagctgagg aaaatggagc
tggaaaagat cctgtccaat 1380gccgaaaagc acttctcttt tctgaagcag
aaagacgaaa aaggactgtc acatagcgag 1440aagatcatta tgctgctgac
cttcaagatc ccttactata ttggcccaat caacgataat 1500cacaagaaat
tctttcccga cagatgctgg gtggtcaaga aagagaaatc cccttctggc
1560aagaccacac catggaactt ctttgatcat atcgacaagg aaaaaacagc
agaggccttc 1620attacttcta ggaccaattt ttgcacttac ctggtgggag
agagcgtcct gcctaagtct 1680agtctgctgt actccgaata taccgtgctg
aacgagatca acaatctgca gatcattatc 1740gatggcaaga atatttgtga
catcaagctg aaacagaaga tctacgagga cctgttcaag 1800aagtacaaga
aaattaccca gaagcagatc agcaccttca tcaagcacga aggcatctgc
1860aacaaaaccg atgaagtgat catcctgggg attgacaagg aatgtacatc
aagcctgaaa 1920agctacatcg agctgaaaaa cattttcggc aagcaggtgg
atgagatctc cactaagaat 1980atgctggagg aaattatcag atgggctacc
atctacgacg agggggaagg aaagaccatc 2040ctgaaaacaa agatcaaggc
agaatacgga aagtattgct ccgacgagca gattaagaaa 2100atcctgaacc
tgaagttctc cggctggggg cgactgtctc ggaaatttct ggagacagtg
2160actagtgaaa tgcccggctt ctcagaacct gtcaatatta tcaccgccat
gagggagaca 2220cagaacaatc tgatggagct gctgtcctct gagttcacct
tcaccgagaa cattaagaaa 2280atcaattctg gattcgaaga tgccgagaag
cagtttagtt acgacggcct ggtgaaacca 2340ctgtttctga gtccctcagt
caagaaaatg ctgtggcaga ccctgaagct ggtgaaagag 2400attagccata
tcacacaggc cccccctaag aaaattttca tcgaaatggc aaagggggcc
2460gagctggaac ctgctcggac taagaccaga ctgaaaatcc tgcaggatct
gtataacaat 2520tgtaagaacg atgctgacgc cttcagctca gagatcaaag
acctgagcgg aaagattgag 2580aacgaagata atctgaggct gcgctccgac
aagctgtacc tgtactatac tcagctgggg 2640aaatgcatgt attgtggaaa
gccaattgag atcggccacg tgttcgatac ctcaaactac 2700gatattgacc
atatctatcc ccagagcaag atcaaagacg atagcatttc caatcgggtg
2760ctggtctgca gctcctgtaa caagaacaag gaggacaagt acccactgaa
atcagagatc 2820cagagcaagc agcgcggctt ctggaacttt ctgcagcgaa
acaatttcat ttctctggag 2880aagctgaata gactgacaag ggccactcca
atcagtgacg atgagacagc caagtttatt 2940gctaggcagc tggtggaaac
tcgccaggct accaaggtgg ccgctaaagt cctggaaaag 3000atgttccccg
agacaaaaat cgtgtacagc aaggccgaga ctgtctccat gttccggaac
3060aagtttgata tcgtgaagtg cagagaaatt aacgattttc accatgctca
cgacgcatac 3120ctgaatatcg tggtcggcaa cgtgtataat accaagttca
caaacaatcc ttggaacttt 3180atcaaggaga aaagagataa tccaaagatt
gctgacacct acaactacta taaggtgttc 3240gattatgacg tcaaaaggaa
caatatcaca gcatgggaga aggggaaaac tattatcacc 3300gtgaaagaca
tgctgaagag aaacacacca atctacacta ggcaggcagc ctgtaagaaa
3360ggggagctgt tcaatcagac cattatgaag aaaggactgg gccagcaccc
cctgaagaaa 3420gaaggacctt tttccaatat ctctaaatac ggcgggtata
acaaggtgag cgctgcatac 3480tatacactga ttgagtatga ggaaaagggc
aacaaaatcc gctccctgga aactattccc 3540ctgtacctgg tgaaagatat
ccagaaggat caggacgtcc tgaagtctta tctgacagac 3600ctgctgggga
agaaagagtt caagatcctg gtgcccaaga tcaagatcaa cagcctgctg
3660aagatcaatg ggtttccttg ccatattaca ggaaaaacta acgatagttt
cctgctgcgc 3720cctgccgtgc agttttgctg ttcaaacaat gaggtcctgt
acttcaagaa aattatccgg 3780ttttccgaaa tccgctctca gcgagagaag
atcgggaaaa caattagccc atacgaggac 3840ctgagcttcc ggtcatatat
caaggagaac ctgtggaaga aaactaagaa cgatgaaatc 3900ggagagaagg
aattttacga cctgctgcag aagaaaaacc tggagatcta tgatatgctg
3960ctgactaagc acaaagacac catctacaag aaacgcccta attctgccac
cattgatatc 4020ctggtgaagg ggaaagagaa gttcaaaagc ctgattatcg
aaaaccagtt tgaagtgatc 4080ctggagatcc tgaagctgtt ttctgcaaca
cggaatgtca gtgacctgca gcatatcgga 4140ggcagcaagt actccggcgt
ggccaaaatc gggaacaaga tctctagtct ggataactgt 4200atcctgatct
atcagtccat caccggcatc ttcgagaaac ggatcgacct gctgaaggtg
4260taagaattc 4269170119RNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotide 170nnnnnnnnnn
nnnnnnnnnn guuugagagu aggaaacuac acgguucaaa uaaagaauuu 60uucuaaucgc
ccaaugggcc cauauugaua uggaugaaac ucgcuuagcg aguuuuuuu
1191711365PRTFilifactor alocis 171Met Thr Lys Glu Tyr Tyr Leu Gly
Leu Asp Val Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala Val Thr Asp
Ser Gln Tyr Asn Leu Cys Lys Phe Lys Lys 20 25 30 Lys Asp Met Trp
Gly Ile Arg Leu Phe Glu Ser Ala Asn Thr Ala Lys 35 40 45 Asp Arg
Arg Leu Gln Arg Gly Asn Arg Arg Arg Leu Glu Arg Lys Lys 50 55 60
Gln Arg Ile Asp Leu Leu Gln Glu Ile Phe Ser Pro Glu Ile Cys Lys 65
70 75 80 Ile Asp Pro Thr Phe Phe Ile Arg Leu Asn Glu Ser Arg Leu
His Leu 85 90 95 Glu Asp Lys Ser Asn Asp Phe Lys Tyr Pro Leu Phe
Ile Glu Lys Asp 100 105 110 Tyr Ser Asp Ile Glu Tyr Tyr Lys Glu Phe
Pro Thr Ile Phe His Leu 115 120 125 Arg Lys His Leu Ile Glu Ser Glu
Glu Lys Gln Asp Ile Arg Leu Ile 130 135 140 Tyr Leu Ala Leu His Asn
Ile Ile Lys Thr Arg Gly His Phe Leu Ile 145 150 155 160 Asp Gly Asp
Leu Gln Ser Ala Lys Gln Leu Arg Pro Ile Leu Asp Thr 165 170 175 Phe
Leu Leu Ser Leu Gln Glu Glu Gln Asn Leu Ser Val Ser Leu Ser 180 185
190 Glu Asn Gln Lys Asp Glu Tyr Glu Glu Ile Leu Lys Asn Arg Ser Ile
195 200 205 Ala Lys Ser Glu Lys Val Lys Lys Leu Lys Asn Leu Phe Glu
Ile Ser 210 215 220 Asp Glu Leu Glu Lys Glu Glu Lys Lys Ala Gln Ser
Ala Val Ile Glu 225 230 235 240 Asn Phe Cys Lys Phe Ile Val Gly Asn
Lys Gly Asp Val Cys Lys Phe 245 250 255 Leu Arg Val Ser Lys Glu Glu
Leu Glu Ile Asp Ser Phe Ser Phe Ser 260 265 270 Glu Gly Lys Tyr Glu
Asp Asp Ile Val Lys Asn Leu Glu Glu Lys Val 275 280 285 Pro Glu Lys
Val Tyr Leu Phe Glu Gln Met Lys Ala Met Tyr Asp Trp 290 295 300 Asn
Ile Leu Val Asp Ile Leu Glu Thr Glu Glu Tyr Ile Ser Phe Ala 305 310
315 320 Lys Val Lys Gln Tyr Glu Lys His Lys Thr Asn Leu Arg Leu Leu
Arg 325 330 335 Asp Ile Ile Leu Lys Tyr Cys Thr Lys Asp Glu Tyr Asn
Arg Met Phe 340 345 350 Asn Asp Glu Lys Glu Ala Gly Ser Tyr Thr Ala
Tyr Val Gly Lys Leu 355 360 365 Lys Lys Asn Asn Lys Lys Tyr Trp Ile
Glu Lys Lys Arg Asn Pro Glu 370 375 380 Glu Phe Tyr Lys Ser Leu Gly
Lys Leu Leu Asp Lys Ile Glu Pro Leu 385 390 395 400 Lys Glu Asp Leu
Glu Val Leu Thr Met Met Ile Glu Glu Cys Lys Asn 405 410 415 His Thr
Leu Leu Pro Ile Gln Lys Asn Lys Asp Asn Gly Val Ile Pro 420 425 430
His Gln Val His Glu Val Glu Leu Lys Lys Ile Leu Glu Asn Ala Lys 435
440 445 Lys Tyr Tyr Ser Phe Leu Thr Glu Thr Asp Lys Asp Gly Tyr Ser
Val 450 455 460 Val Gln Lys Ile Glu Ser Ile Phe Arg Phe Arg Ile Pro
Tyr Tyr Val 465 470 475 480 Gly Pro Leu Ser Thr Arg His Gln Glu Lys
Gly Ser Asn Val Trp Met 485 490 495 Val Arg Lys Pro Gly Arg Glu Asp
Arg Ile Tyr Pro Trp Asn Met Glu 500 505 510 Glu Ile Ile Asp Phe Glu
Lys Ser Asn Glu Asn Phe Ile Thr Arg Met 515 520 525 Thr Asn Lys Cys
Thr Tyr Leu Ile Gly Glu Asp Val Leu Pro Lys His 530 535 540 Ser Leu
Leu Tyr Ser Lys Tyr Met Val Leu Asn Glu Leu Asn Asn Val 545 550 555
560 Lys Val Arg Gly Lys Lys Leu Pro Thr Ser Leu Lys Gln Lys Val Phe
565 570 575 Glu Asp Leu Phe Glu Asn Lys Ser Lys Val Thr Gly Lys Asn
Leu Leu 580 585 590 Glu Tyr Leu Gln Ile Gln Asp Lys Asp Ile Gln Ile
Asp Asp Leu Ser 595 600 605 Gly Phe Asp Lys Asp Phe Lys Thr Ser Leu
Lys Ser Tyr Leu Asp Phe 610 615 620 Lys Lys Gln Ile Phe Gly Glu Glu
Ile Glu Lys Glu Ser Ile Gln Asn 625 630 635 640 Met Ile Glu Asp Ile
Ile Lys Trp Ile Thr Ile Tyr Gly Asn Asp Lys 645 650 655 Glu Met Leu
Lys Arg Val Ile Arg Ala Asn Tyr Ser Asn Gln Leu Thr 660 665 670 Glu
Glu Gln Met Lys Lys Ile Thr Gly Phe Gln Tyr Ser Gly Trp Gly 675 680
685 Asn Phe Ser Lys Met Phe Leu Lys Gly Ile Ser Gly Ser Asp Val Ser
690 695 700 Thr Gly Glu Thr Phe Asp Ile Ile Thr Ala Met Trp Glu Thr
Asp Asn 705 710 715 720 Asn Leu Met Gln Ile Leu Ser Lys Lys Phe Thr
Phe Met Asp Asn Val 725 730 735 Glu Asp Phe Asn Ser Gly Lys Val Gly
Lys Ile Asp Lys Ile Thr Tyr 740 745 750 Asp Ser Thr Val Lys Glu Met
Phe Leu Ser Pro Glu Asn Lys Arg Ala 755 760 765 Val Trp Gln Thr Ile
Gln Val Ala Glu Glu Ile Lys Lys Val Met Gly 770 775 780 Cys Glu Pro
Lys Lys Ile Phe Ile Glu Met Ala Arg Gly Gly Glu Lys 785 790 795 800
Val Lys Lys Arg Thr Lys Ser Arg Lys Ala Gln Leu Leu Glu Leu Tyr 805
810 815 Ala Ala Cys Glu Glu Asp Cys Arg Glu Leu Ile Lys Glu Ile Glu
Asp 820 825 830 Arg Asp Glu Arg Asp Phe Asn Ser Met Lys Leu Phe Leu
Tyr Tyr Thr 835 840 845 Gln Phe Gly Lys Cys Met Tyr Ser Gly Asp Asp
Ile Asp Ile Asn Glu 850 855 860 Leu Ile Arg Gly Asn Ser Lys Trp Asp
Arg Asp His Ile Tyr Pro Gln 865 870 875 880 Ser Lys Ile Lys Asp Asp
Ser Ile Asp Asn Leu Val Leu Val Asn Lys 885 890 895 Thr Tyr Asn Ala
Lys Lys Ser Asn Glu Leu Leu Ser Glu Asp Ile Gln 900 905 910 Lys Lys
Met His Ser Phe Trp Leu Ser Leu Leu Asn Lys Lys Leu Ile 915 920 925
Thr Lys Ser Lys Tyr Asp Arg Leu Thr Arg Lys Gly Asp Phe Thr Asp 930
935 940 Glu Glu Leu Ser Gly Phe Ile Ala Arg Gln Leu Val Glu Thr Arg
Gln 945 950 955 960 Ser Thr Lys Ala Ile Ala Asp Ile Phe Lys Gln Ile
Tyr Ser Ser Glu 965 970 975 Val Val Tyr Val Lys Ser Ser Leu Val Ser
Asp Phe Arg Lys Lys Pro 980 985 990 Leu Asn Tyr Leu Lys Ser Arg Arg
Val Asn Asp Tyr His His Ala Lys 995 1000 1005 Asp Ala Tyr Leu Asn
Ile Val Val Gly Asn Val Tyr Asn Lys Lys 1010 1015 1020 Phe Thr Ser
Asn Pro Ile Gln Trp Met Lys Lys Asn Arg Asp Thr 1025 1030 1035 Asn
Tyr Ser Leu Asn Lys Val Phe Glu His Asp Val Val Ile Asn 1040 1045
1050 Gly Glu Val Ile Trp Glu Lys Cys Thr Tyr His Glu Asp Thr Asn
1055 1060 1065 Thr Tyr Asp Gly Gly Thr Leu Asp Arg Ile Arg Lys Ile
Val Glu 1070 1075 1080 Arg Asp Asn Ile Leu Tyr Thr Glu Tyr Ala Tyr
Cys Glu Lys Gly 1085 1090 1095 Glu Leu Phe Asn Ala Thr Ile Gln Asn
Lys Asn Gly Asn Ser Thr 1100 1105 1110 Val Ser Leu Lys Lys Gly Leu
Asp Val Lys Lys Tyr Gly Gly Tyr 1115 1120 1125 Phe Ser Ala Asn Thr
Ser Tyr Phe Ser Leu Ile Glu Phe Glu Asp 1130 1135 1140 Lys Lys Gly
Asp Arg Ala Arg His Ile Ile Gly Val Pro Ile Tyr 1145 1150 1155 Ile
Ala Asn Met Leu Glu His Ser Pro Ser Ala Phe Leu Glu Tyr 1160 1165
1170 Cys Glu Gln Lys Gly Tyr Gln Asn Val Arg Ile Leu Val Glu Lys
1175 1180 1185 Ile Lys Lys Asn Ser Leu Leu Ile Ile Asn Gly Tyr Pro
Leu Arg 1190 1195 1200 Ile Arg Gly Glu Asn Glu Val Asp Thr Ser Phe
Lys Arg Ala Ile 1205 1210 1215 Gln Leu Lys Leu Asp Gln Lys Asn Tyr
Glu Leu Val Arg Asn Ile 1220 1225 1230 Glu Lys Phe Leu Glu Lys Tyr
Val Glu Lys Lys Gly Asn Tyr Pro 1235 1240 1245 Ile Asp Glu Asn Arg
Asp His Ile Thr His Glu Lys Met Asn Gln 1250 1255 1260 Leu Tyr Glu
Val Leu Leu Ser Lys Met Lys Lys Phe Asn Lys Lys 1265 1270 1275 Gly
Met Ala Asp Pro Ser Asp Arg Ile Glu Lys Ser Lys Pro Lys 1280 1285
1290 Phe Ile Lys Leu Glu Asp Leu Ile Asp Lys Ile Asn Val Ile Asn
1295 1300 1305 Lys Met Leu Asn Leu Leu Arg Cys Asp Asn Asp Thr Lys
Ala Asp 1310 1315 1320 Leu Ser Leu Ile Glu Leu Pro Lys Asn Ala Gly
Ser Phe Val Val 1325 1330 1335 Lys Lys Asn Thr Ile Gly Lys Ser Lys
Ile Ile Leu Val Asn Gln 1340 1345 1350 Ser Val Thr Gly Leu Tyr Glu
Asn Arg Arg Glu Leu 1355 1360 1365 1724179DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
172accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtccatgac caaggagtat tacctggggc tggatgtggg
gaccaattcc 120gtgggatggg cagtgaccga ttctcagtac aacctgtgca
agtttaagaa aaaggatatg 180tggggcatcc ggctgttcga aagcgccaac
acagcaaagg accggagact gcagagaggg 240aataggcgcc gactggagcg
gaaaaagcag agaattgatc tgctgcagga aatcttctcc 300ccagagatct
gcaagattga ccccactttc tttatccgac tgaacgaatc ccggctgcac
360ctggaggaca agtctaacga tttcaaatac ccactgttta ttgagaagga
ctattctgat 420atcgagtact ataaagagtt ccccaccatt tttcacctga
ggaagcatct gatcgagagt 480gaggaaaaac aggatatccg gctgatctac
ctggccctgc acaacatcat taagacccga 540ggacattttc tgattgacgg
cgatctgcag agcgccaagc agctgaggcc catcctggat 600acattcctgc
tgtccctgca ggaggaacag aacctgtcag tgagcctgtc cgaaaatcag
660aaggacgagt atgaggaaat tctgaaaaac cgcagcatcg ccaagtccga
aaaagtgaaa 720aagctgaaga atctgtttga gatctcagac gagctggaaa
aagaggagaa gaaggcccag 780agcgccgtga tcgagaactt ctgcaagttt
atcgtgggaa ataagggcga tgtctgtaaa 840ttcctgcggg tgtctaagga
ggaactggag attgactctt tcagtttttc agagggcaag 900tacgaggacg
acatcgtgaa aaacctggag gaaaaagtgc
ctgaaaaggt ctacctgttt 960gagcagatga aggcaatgta tgattggaat
attctggtcg acatcctgga aaccgaggaa 1020tacatcagct tcgccaaagt
gaagcagtat gagaaacaca agactaacct gcggctgctg 1080agagacatca
ttctgaaata ctgcaccaag gatgagtata atcggatgtt taacgacgag
1140aaggaagctg gcagctacac cgcatatgtg gggaaactga aaaagaacaa
caagaagtac 1200tggatcgaga aaaagagaaa tcccgaggag ttctacaaat
ccctgggcaa gctgctggat 1260aaaattgagc ctctgaagga ggacctggaa
gtgctgacta tgatgatcga ggagtgtaag 1320aaccacaccc tgctgccaat
tcagaaaaat aaggacaacg gcgtgatccc ccaccaggtg 1380catgaggtcg
aactgaaaaa gatcctggaa aatgccaaaa agtactattc cttcctgacc
1440gagacagaca aggatgggta ctcagtggtc cagaaaatcg agagcatttt
caggtttcgc 1500atcccctact atgtggggcc tctgagtacc cggcaccagg
aaaagggatc aaacgtgtgg 1560atggtcagaa aacctggcag ggaggatcgc
atctacccat ggaatatgga ggaaatcatt 1620gactttgaga agagcaacga
aaatttcatt acacggatga ctaacaaatg tacatatctg 1680atcggggaag
atgtcctgcc caagcattct ctgctgtaca gtaaatatat ggtgctgaat
1740gagctgaaca atgtgaaggt cagaggaaaa aagctgccta catctctgaa
acagaaggtg 1800ttcgaggacc tgtttgaaaa caaatccaaa gtgactggaa
agaatctgct ggagtacctg 1860cagatccagg acaaagatat ccagattgac
gatctgtctg gcttcgacaa ggacttcaag 1920accagcctga agagctatct
ggacttcaaa aagcagattt ttggggagga aatcgagaag 1980gaaagcattc
agaacatgat cgaagatatc attaagtgga tcaccatcta cggcaatgac
2040aaggagatgc tgaaacgagt gattcgggct aattatagca accagctgac
agaggaacag 2100atgaaaaaga tcactggatt tcagtacagt ggctggggga
acttctcaaa gatgtttctg 2160aaagggatca gcggatccga cgtgagcacc
ggcgaaacat tcgacatcat taccgcaatg 2220tgggagacag acaacaatct
gatgcagatc ctgtcaaaaa agttcacctt tatggacaac 2280gtcgaggact
tcaacagcgg caaggtcggg aaaatcgaca agattactta cgatagcacc
2340gtgaaggaaa tgttcctgtc ccctgagaac aaaagggccg tctggcagac
cattcaggtg 2400gctgaggaga tcaagaaagt gatgggctgc gagccaaaaa
agatctttat tgaaatggca 2460cggggcgggg agaaggtgaa aaagaggaca
aaatctcgca aggcccagct gctggagctg 2520tacgccgctt gcgaggaaga
ttgtagagaa ctgatcaagg agattgagga ccgggacgag 2580agggacttca
atagcatgaa gctgtttctg tactataccc agttcgggaa atgtatgtat
2640tccggcgacg acatcgatat taacgagctg attcgcggca attctaagtg
ggaccgagat 2700cacatctacc cccagagcaa aattaaggac gattccatcg
ataacctggt gctggtcaat 2760aagacatata atgccaaaaa gtccaatgag
ctgctgtctg aggacatcca gaaaaagatg 2820cattcattct ggctgagcct
gctgaacaaa aagctgatca ctaaaagcaa gtacgaccgc 2880ctgactcgaa
agggcgactt taccgatgag gaactgagtg ggttcatcgc tagacagctg
2940gtggaaacaa ggcagtcaac taaggcaatc gccgatatct tcaagcagat
ctacagctcc 3000gaggtggtct atgtgaagag cagcctggtg agcgacttca
ggaaaaagcc actgaactac 3060ctgaagtctc ggagagtcaa tgattaccac
catgcaaaag acgcctatct gaacattgtg 3120gtcgggaacg tgtacaacaa
aaagtttacc agtaatccca tccagtggat gaaaaagaat 3180cgcgatacaa
actatagcct gaacaaggtg ttcgaacacg acgtggtcat taacggagaa
3240gtgatctggg aaaagtgcac ataccatgag gacactaata cctatgatgg
aggcactctg 3300gaccgaatcc ggaagattgt ggaacgcgat aacattctgt
acaccgagta cgcttattgt 3360gagaagggcg aactgtttaa tgcaaccatc
cagaacaaaa atggaaactc cacagtctct 3420ctgaaaaagg gcctggacgt
gaaaaagtac gggggatact tcagcgccaa cacaagttac 3480ttctcactga
tcgagtttga ggacaagaag ggggatagag caaggcacat cattggagtg
3540cctatctata ttgcaaacat gctggagcat tctccaagtg ccttcctgga
gtactgcgaa 3600cagaaggggt atcagaatgt gcggattctg gtcgagaaaa
tcaaaaagaa cagcctgctg 3660atcattaatg gataccctct gcgcattcga
ggcgagaacg aagtggatac ttcctttaag 3720agggccatcc agctgaagct
ggaccagaaa aactatgagc tggtccgcaa tatcgagaag 3780ttcctggaaa
aatacgtgga gaaaaaggga aactatccaa ttgacgagaa tagagatcac
3840atcacacatg aaaagatgaa ccagctgtac gaggtgctgc tgtccaaaat
gaaaaagttc 3900aacaagaagg gcatggccga cccctctgat aggatcgaaa
agagtaagcc taaattcatc 3960aagctggagg acctgatcga taagattaat
gtgatcaaca aaatgctgaa cctgctgcgc 4020tgtgacaatg atactaaggc
cgacctgtct ctgattgagc tgcccaaaaa cgctgggagt 4080ttcgtggtca
aaaagaatac catcggaaag tcaaaaatca tcctggtgaa tcagagcgtg
4140actggactgt acgagaatag acgggaactg taagaattc
4179173111RNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 173nnnnnnnnnn nnnnnnnnnn guuuuagcac
uagaaauagu uaaguuaaaa caagcuuaaa 60gcgucaaugu aauauuuuau uaacacccua
cugugucagu gggguuuuuu u 1111741334PRTStaphylococcus
pseudintermedius 174Met Gly Arg Lys Pro Tyr Ile Leu Ser Leu Asp Ile
Gly Thr Gly Ser 1 5 10 15 Val Gly Tyr Ala Cys Met Asp Lys Gly Phe
Asn Val Leu Lys Tyr His 20 25 30 Asp Lys Asp Ala Leu Gly Val Tyr
Leu Phe Asp Gly Ala Leu Thr Ala 35 40 45 Gln Glu Arg Arg Gln Phe
Arg Thr Ser Arg Arg Arg Lys Asn Arg Arg 50 55 60 Ile Lys Arg Leu
Gly Leu Leu Gln Glu Leu Leu Ala Pro Leu Val Gln 65 70 75 80 Asn Pro
Asn Phe Tyr Gln Phe Gln Arg Gln Phe Ala Trp Lys Asn Asp 85 90 95
Asn Met Asp Phe Lys Asn Lys Ser Leu Ser Glu Val Leu Ser Phe Leu 100
105 110 Gly Tyr Glu Ser Lys Lys Tyr Pro Thr Ile Tyr His Leu Gln Glu
Ala 115 120 125 Leu Leu Leu Lys Asp Glu Lys Phe Asp Pro Glu Leu Ile
Tyr Met Ala 130 135 140 Leu Tyr His Leu Val Lys Tyr Arg Gly His Phe
Leu Phe Asp His Leu 145 150 155 160 Lys Ile Glu Asn Leu Thr Asn Asn
Asp Asn Met His Asp Phe Val Glu 165 170 175 Leu Ile Glu Thr Tyr Glu
Asn Leu Asn Asn Ile Lys Leu Asn Leu Asp 180 185 190 Tyr Glu Lys Thr
Lys Val Ile Tyr Glu Ile Leu Lys Asp Asn Glu Met 195 200 205 Thr Lys
Asn Asp Arg Ala Lys Arg Val Lys Asn Met Glu Lys Lys Leu 210 215 220
Glu Gln Phe Ser Ile Met Leu Leu Gly Leu Lys Phe Asn Glu Gly Lys 225
230 235 240 Leu Phe Asn His Ala Asp Asn Ala Glu Glu Leu Lys Gly Ala
Asn Gln 245 250 255 Ser His Thr Phe Ala Asp Asn Tyr Glu Glu Asn Leu
Thr Pro Phe Leu 260 265 270 Thr Val Glu Gln Ser Glu Phe Ile Glu Arg
Ala Asn Lys Ile Tyr Leu 275 280 285 Ser Leu Thr Leu Gln Asp Ile Leu
Lys Gly Lys Lys Ser Met Ala Met 290 295 300 Ser Lys Val Ala Ala Tyr
Asp Lys Phe Arg Asn Glu Leu Lys Gln Val 305 310 315 320 Lys Asp Ile
Val Tyr Lys Ala Asp Ser Thr Arg Thr Gln Phe Lys Lys 325 330 335 Ile
Phe Val Ser Ser Lys Lys Ser Leu Lys Gln Tyr Asp Ala Thr Pro 340 345
350 Asn Asp Gln Thr Phe Ser Ser Leu Cys Leu Phe Asp Gln Tyr Leu Ile
355 360 365 Arg Pro Lys Lys Gln Tyr Ser Leu Leu Ile Lys Glu Leu Lys
Lys Ile 370 375 380 Ile Pro Gln Asp Ser Glu Leu Tyr Phe Glu Ala Glu
Asn Asp Thr Leu 385 390 395 400 Leu Lys Val Leu Asn Thr Thr Asp Asn
Ala Ser Ile Pro Met Gln Ile 405 410 415 Asn Leu Tyr Glu Ala Glu Thr
Ile Leu Arg Asn Gln Gln Lys Tyr His 420 425 430 Ala Glu Ile Thr Asp
Glu Met Ile Glu Lys Val Leu Ser Leu Ile Gln 435 440 445 Phe Arg Ile
Pro Tyr Tyr Val Gly Pro Leu Val Asn Asp His Thr Ala 450 455 460 Ser
Lys Phe Gly Trp Met Glu Arg Lys Ser Asn Glu Ser Ile Lys Pro 465 470
475 480 Trp Asn Phe Asp Glu Val Val Asp Arg Ser Lys Ser Ala Thr Gln
Phe 485 490 495 Ile Arg Arg Met Thr Asn Lys Cys Ser Tyr Leu Ile Asn
Glu Asp Val 500 505 510 Leu Pro Lys Asn Ser Leu Leu Tyr Gln Glu Met
Glu Val Leu Asn Glu 515 520 525 Leu Asn Ala Thr Gln Ile Arg Leu Gln
Thr Asp Pro Lys Asn Arg Lys 530 535 540 Tyr Arg Met Met Pro Gln Ile
Lys Leu Phe Ala Val Glu His Ile Phe 545 550 555 560 Lys Lys Tyr Lys
Thr Val Ser His Ser Lys Phe Leu Glu Ile Met Leu 565 570 575 Asn Ser
Asn His Arg Glu Asn Phe Met Asn His Gly Glu Lys Leu Ser 580 585 590
Ile Phe Gly Thr Gln Asp Asp Lys Lys Phe Ala Ser Lys Leu Ser Ser 595
600 605 Tyr Gln Asp Met Thr Lys Ile Phe Gly Asp Ile Glu Gly Lys Arg
Ala 610 615 620 Gln Ile Glu Glu Ile Ile Gln Trp Ile Thr Ile Phe Glu
Asp Lys Lys 625 630 635 640 Ile Leu Val Gln Lys Leu Lys Glu Cys Tyr
Pro Glu Leu Thr Ser Lys 645 650 655 Gln Ile Asn Gln Leu Lys Lys Leu
Asn Tyr Ser Gly Trp Gly Arg Leu 660 665 670 Ser Glu Lys Leu Leu Thr
His Ala Tyr Gln Gly His Ser Ile Ile Glu 675 680 685 Leu Leu Arg His
Ser Asp Glu Asn Phe Met Glu Ile Leu Thr Asn Asp 690 695 700 Val Tyr
Gly Phe Gln Asn Phe Ile Lys Glu Glu Asn Gln Val Gln Ser 705 710 715
720 Asn Lys Ile Gln His Gln Asp Ile Ala Asn Leu Thr Thr Ser Pro Ala
725 730 735 Leu Lys Lys Gly Ile Trp Ser Thr Ile Lys Leu Val Arg Glu
Leu Thr 740 745 750 Ser Ile Phe Gly Glu Pro Glu Lys Ile Ile Met Glu
Phe Ala Thr Glu 755 760 765 Asp Gln Gln Lys Gly Lys Lys Gln Lys Ser
Arg Lys Gln Leu Trp Asp 770 775 780 Asp Asn Ile Lys Lys Asn Lys Leu
Lys Ser Val Asp Glu Tyr Lys Tyr 785 790 795 800 Ile Ile Asp Val Ala
Asn Lys Leu Asn Asn Glu Gln Leu Gln Gln Glu 805 810 815 Lys Leu Trp
Leu Tyr Leu Ser Gln Asn Gly Lys Cys Met Tyr Ser Gly 820 825 830 Gln
Ser Ile Asp Leu Asp Ala Leu Leu Ser Pro Asn Ala Thr Lys His 835 840
845 Tyr Glu Val Asp His Ile Phe Pro Arg Ser Phe Ile Lys Asp Asp Ser
850 855 860 Ile Asp Asn Lys Val Leu Val Ile Lys Lys Met Asn Gln Thr
Lys Gly 865 870 875 880 Asp Gln Val Pro Leu Gln Phe Ile Gln Gln Pro
Tyr Glu Arg Ile Ala 885 890 895 Tyr Trp Lys Ser Leu Asn Lys Ala Gly
Leu Ile Ser Asp Ser Lys Leu 900 905 910 His Lys Leu Met Lys Pro Glu
Phe Thr Ala Met Asp Lys Glu Gly Phe 915 920 925 Ile Gln Arg Gln Leu
Val Glu Thr Arg Gln Ile Ser Val His Val Arg 930 935 940 Asp Phe Leu
Lys Glu Glu Tyr Pro Asn Thr Lys Val Ile Pro Met Lys 945 950 955 960
Ala Lys Met Val Ser Glu Phe Arg Lys Lys Phe Asp Ile Pro Lys Ile 965
970 975 Arg Gln Met Asn Asp Ala His His Ala Ile Asp Ala Tyr Leu Asn
Gly 980 985 990 Val Val Tyr His Gly Ala Gln Leu Ala Tyr Pro Asn Val
Asp Leu Phe 995 1000 1005 Asp Phe Asn Phe Lys Trp Glu Lys Val Arg
Glu Lys Trp Lys Ala 1010 1015 1020 Leu Gly Glu Phe Asn Thr Lys Gln
Lys Ser Arg Glu Leu Phe Phe 1025 1030 1035 Phe Lys Lys Leu Glu Lys
Met Glu Val Ser Gln Gly Glu Arg Leu 1040 1045 1050 Ile Ser Lys Ile
Lys Leu Asp Met Asn His Phe Lys Ile Asn Tyr 1055 1060 1065 Ser Arg
Lys Leu Ala Asn Ile Pro Gln Gln Phe Tyr Asn Gln Thr 1070 1075 1080
Ala Val Ser Pro Lys Thr Ala Glu Leu Lys Tyr Glu Ser Asn Lys 1085
1090 1095 Ser Asn Glu Val Val Tyr Lys Gly Leu Thr Pro Tyr Gln Thr
Tyr 1100 1105 1110 Val Val Ala Ile Lys Ser Val Asn Lys Lys Gly Lys
Glu Lys Met 1115 1120 1125 Glu Tyr Gln Met Ile Asp His Tyr Val Phe
Asp Phe Tyr Lys Phe 1130 1135 1140 Gln Asn Gly Asn Glu Lys Glu Leu
Ala Leu Tyr Leu Ala Gln Arg 1145 1150 1155 Glu Asn Lys Asp Glu Val
Leu Asp Ala Gln Ile Val Tyr Ser Leu 1160 1165 1170 Asn Lys Gly Asp
Leu Leu Tyr Ile Asn Asn His Pro Cys Tyr Phe 1175 1180 1185 Val Ser
Arg Lys Glu Val Ile Asn Ala Lys Gln Phe Glu Leu Thr 1190 1195 1200
Val Glu Gln Gln Leu Ser Leu Tyr Asn Val Met Asn Asn Lys Glu 1205
1210 1215 Thr Asn Val Glu Lys Leu Leu Ile Glu Tyr Asp Phe Ile Ala
Glu 1220 1225 1230 Lys Val Ile Asn Glu Tyr His His Tyr Leu Asn Ser
Lys Leu Lys 1235 1240 1245 Glu Lys Arg Val Arg Thr Phe Phe Ser Glu
Ser Asn Gln Thr His 1250 1255 1260 Glu Asp Phe Ile Lys Ala Leu Asp
Glu Leu Phe Lys Val Val Thr 1265 1270 1275 Ala Ser Ala Thr Arg Ser
Asp Lys Ile Gly Ser Arg Lys Asn Ser 1280 1285 1290 Met Thr His Arg
Ala Phe Leu Gly Lys Gly Lys Asp Val Lys Ile 1295 1300 1305 Ala Tyr
Thr Ser Ile Ser Gly Leu Lys Thr Thr Lys Pro Lys Ser 1310 1315 1320
Leu Phe Lys Leu Ala Glu Ser Arg Asn Glu Leu 1325 1330
1754086DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 175accggtgcca ccatgtaccc atacgatgtt
ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag cgtccatggg gaggaaacct
tacattctgt ctctggatat tggaactggg 120tccgtcggct acgcttgcat
ggataaagga ttcaacgtgc tgaagtacca cgacaaagat 180gccctgggag
tgtatctgtt cgacggcgct ctgactgcac aggagcggag acagtttagg
240acctccaggc gccgaaagaa ccggagaatc aaacgcctgg gcctgctgca
ggaactgctg 300gcacccctgg tgcagaaccc taatttctac cagtttcagc
ggcagttcgc ctggaagaac 360gacaatatgg attttaagaa caagagcctg
tctgaggtgc tgagcttcct gggatatgaa 420tccaagaaat accctaccat
ctaccacctg caggaggctc tgctgctgaa agacgagaag 480tttgatccag
aactgatcta catggcactg tatcatctgg tgaaatacag aggccacttt
540ctgttcgatc atctgaagat cgagaacctg actaacaatg acaatatgca
cgatttcgtg 600gagctgattg aaacctatga gaacctgaac aatatcaagc
tgaatctgga ctacgagaaa 660accaaagtga tctatgagat tctgaaagac
aacgaaatga ctaagaatga tagagccaaa 720agggtcaaga acatggagaa
gaaactggaa cagttctcta tcatgctgct ggggctgaag 780ttcaatgagg
gaaaactgtt taaccacgcc gataatgctg aggaactgaa gggggctaac
840cagagccata catttgcaga caactacgag gaaaatctga ctcccttcct
gaccgtggaa 900cagtcagagt ttattgaaag ggccaacaaa atctatctga
gcctgactct gcaggatatc 960ctgaagggca agaaatcaat ggctatgagc
aaagtggccg cttacgacaa gttcagaaat 1020gagctgaaac aggtgaagga
cattgtctat aaggctgatt ctaccaggac acagttcaag 1080aaaatctttg
tgagctccaa gaaaagtctg aagcagtacg acgcaactcc caacgatcag
1140accttctcta gtctgtgcct gtttgaccag tacctgattc gcccaaagaa
acagtatagc 1200ctgctgatca aggagctgaa gaaaatcatt ccccaggact
ccgaactgta ctttgaggca 1260gaaaatgata ccctgctgaa ggtgctgaac
accacagaca atgctagcat ccctatgcag 1320attaacctgt acgaggcaga
aaccatcctg cgaaatcagc agaaatatca cgccgagatc 1380acagatgaga
tgattgaaaa ggtgctgtct ctgatccagt tccgcattcc atactatgtg
1440gggcccctgg tcaacgacca tacagccagt aagtttggat ggatggagcg
caaaagtaac 1500gaatcaatca agccttggaa tttcgacgag gtggtcgatc
gaagtaaatc agccactcag 1560tttattaggc gcatgaccaa caagtgttcc
tacctgatca atgaggatgt gctgccaaaa 1620aactctctgc tgtatcagga
gatggaagtc ctgaacgaac tgaatgccac acagatcagg 1680ctgcagactg
acccaaaaaa ccgcaagtac cgaatgatgc cccagattaa gctgttcgct
1740gtggagcaca tctttaagaa atataaaacc gtcagccatt ccaagttcct
ggaaattatg 1800ctgaacagca atcacaggga gaactttatg aatcatggag
aaaagctgag tatcttcggc 1860acacaggacg ataagaaatt tgcatcaaag
ctgtcaagct accaggacat gactaaaatc 1920ttcggggata ttgagggaaa
gcgcgcccag attgaggaaa tcattcagtg gatcaccatt 1980tttgaggaca
agaaaatcct ggtgcagaag ctgaaagagt gctatcctga actgacatcc
2040aagcagatca accagctgaa gaaactgaat tactctggct gggggaggct
gagtgagaag 2100ctgctgactc acgcctatca gggccatagc atcattgaac
tgctgcgcca ctccgatgag 2160aatttcatgg aaattctgac caacgacgtg
tacgggttcc agaattttat caaagaggaa 2220aaccaggtcc agagcaataa
gatccagcat caggatattg ccaacctgac tacctctccc 2280gctctgaaga
aaggcatctg gagtacaatt aagctggtgc gggagctgac ttccattttc
2340ggggagcctg aaaagatcat tatggagttt gctaccgagg accagcagaa
aggcaagaaa 2400cagaaatcaa gaaagcagct gtgggacgat aacatcaaga
aaaataagct gaaaagcgtg 2460gacgagtaca aatatatcat tgatgtcgcc
aataagctga acaatgagca gctgcagcag 2520gaaaaactgt ggctgtacct
gagccagaac ggcaagtgta tgtatagcgg gcagtccatc 2580gacctggatg
ccctgctgtc ccccaatgct accaagcact acgaggtgga tcatattttc
2640cctcggagct tcatcaagga cgatagcatt gacaacaagg tgctggtcat
caagaaaatg 2700aatcagacaa agggcgatca ggtgcccctg cagttcattc
agcagcctta cgagagaatc 2760gcatattgga agagcctgaa caaagccggg
ctgatctctg atagtaaact gcacaagctg 2820atgaaaccag agttcacagc
tatggacaag gaaggcttca tccagcggca gctggtggag 2880actagacaga
tcagcgtgca tgtccgggat tttctgaaag aggaataccc taataccaaa
2940gtgatcccaa tgaaggccaa aatggtgagc gagttccgga agaaatttga
catcccaaag 3000attagacaga tgaacgacgc acaccatgcc atcgatgctt
acctgaatgg cgtggtctat 3060cacggggcac agctggccta ccccaacgtg
gacctgtttg atttcaattt taagtgggag 3120aaagtccgag aaaagtggaa
agccctggga gagttcaaca caaagcagaa atctcgggaa 3180ctgttctttt
tcaagaaact ggagaagatg gaagtgtccc agggcgagcg gctgatctct
3240aagatcaagc tggacatgaa ccacttcaag atcaactact ccagaaagct
ggccaacatc 3300cctcagcagt tttataatca gaccgcagtg tctccaaaga
cagccgagct gaaatacgaa 3360tctaacaaga gtaatgaggt ggtctataag
ggactgacac cataccagac ttatgtggtc 3420gccatcaaga gcgtgaacaa
gaaaggcaag gagaaaatgg aataccagat gatcgaccac 3480tacgtgttcg
atttttataa attccagaac ggcaatgaga aggaactggc tctgtacctg
3540gcacagaggg agaacaagga cgaagtgctg gatgctcaga ttgtctatag
tctgaataag 3600ggggatctgc tgtacatcaa caatcatccc tgctatttcg
tgtcacgcaa agaggtcatc 3660aacgcaaagc agtttgagct gaccgtggaa
cagcagctgt ctctgtacaa cgtgatgaac 3720aacaaggaga caaatgtcga
aaagctgctg atcgagtatg acttcattgc cgagaaagtg 3780atcaacgaat
accaccatta tctgaatagc aagctgaaag aaaagcgagt ccggaccttt
3840ttctcagaga gcaaccagac acacgaggac ttcatcaagg ccctggacga
gctgtttaag 3900gtggtcaccg catccgccac aaggtctgat aaaatcggga
gtcgcaagaa cagcatgact 3960catcgagcct tcctgggaaa aggcaaggac
gtgaagattg cttacacctc catctctgga 4020ctgaaaacaa ctaaacctaa
gagtctgttt aagctggccg agtcaagaaa cgaactgtaa 4080gaattc
4086176114RNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 176nnnnnnnnnn nnnnnnnnnn guuuuagaug
gugaaaacca gauuuaaaau caagcaaugc 60aucuuuugau gcaaaguuuc aauauuuguc
ccacguuauc gagggacuuu uuuu 1141771375PRTLactobacillus johnsonii
177Met Thr Lys Ile Lys Asp Asp Tyr Ile Val Gly Leu Asp Ile Gly Thr
1 5 10 15 Asp Ser Cys Gly Trp Val Ala Met Asn Ser Asn Asn Asp Ile
Leu Lys 20 25 30 Leu Gln Gly Lys Thr Ala Ile Gly Ser Arg Leu Phe
Glu Gly Gly Lys 35 40 45 Ser Ala Ala Glu Arg Arg Leu Phe Arg Thr
Thr His Arg Arg Ile Lys 50 55 60 Arg Arg Arg Trp Arg Leu Lys Leu
Leu Glu Glu Phe Phe Asp Pro Tyr 65 70 75 80 Met Ala Glu Val Asp Pro
Tyr Phe Phe Ala Arg Leu Lys Glu Ser Gly 85 90 95 Leu Ser Pro Leu
Asp Lys Arg Lys Thr Val Ser Ser Ile Val Phe Pro 100 105 110 Thr Ser
Ala Glu Asp Lys Lys Phe Tyr Asp Asp Tyr Pro Thr Ile Tyr 115 120 125
His Leu Arg Tyr Lys Leu Met Thr Glu Asp Glu Lys Phe Asp Leu Arg 130
135 140 Glu Val Tyr Leu Ala Ile His His Ile Ile Lys Tyr Arg Gly Asn
Phe 145 150 155 160 Leu Tyr Asn Thr Ser Val Lys Asp Phe Lys Ala Ser
Lys Ile Asp Val 165 170 175 Lys Ser Ser Ile Glu Lys Leu Asn Glu Leu
Tyr Glu Asn Leu Gly Leu 180 185 190 Asp Leu Asn Val Glu Phe Asn Ile
Ser Asn Thr Ala Glu Ile Glu Lys 195 200 205 Val Leu Lys Asp Lys Gln
Ile Phe Lys Arg Asp Lys Val Lys Lys Ile 210 215 220 Ala Glu Leu Phe
Ala Ile Lys Thr Asp Asn Lys Glu Gln Ser Lys Arg 225 230 235 240 Ile
Lys Asp Ile Ser Lys Gln Val Ala Asn Ala Val Leu Gly Tyr Lys 245 250
255 Thr Arg Phe Asp Thr Ile Ala Leu Lys Glu Ile Ser Lys Asp Glu Leu
260 265 270 Ser Asp Trp Asn Phe Lys Leu Ser Asp Ile Asp Ala Asp Ser
Lys Phe 275 280 285 Glu Ala Leu Met Gly Asn Leu Asp Glu Asn Glu Gln
Ala Ile Leu Leu 290 295 300 Thr Ile Lys Glu Leu Phe Asn Glu Val Thr
Leu Asn Gly Ile Val Glu 305 310 315 320 Asp Gly Asn Thr Leu Ser Glu
Ser Met Ile Asn Lys Tyr Asn Asp His 325 330 335 Arg Asp Asp Leu Lys
Leu Leu Lys Glu Val Ile Glu Asn His Ile Asp 340 345 350 Arg Lys Lys
Ala Lys Glu Leu Ala Leu Ala Tyr Asp Leu Tyr Val Asn 355 360 365 Asn
Arg His Gly Gln Leu Leu Gln Ala Lys Lys Lys Leu Gly Lys Ile 370 375
380 Lys Pro Arg Ser Lys Glu Asp Phe Tyr Lys Val Val Asn Lys Asn Leu
385 390 395 400 Asp Asp Ser Arg Ala Ser Lys Glu Ile Lys Lys Lys Ile
Glu Leu Asp 405 410 415 Ser Phe Met Pro Lys Gln Arg Thr Asn Ala Asn
Gly Val Ile Pro Tyr 420 425 430 Gln Leu Gln Gln Leu Glu Leu Asp Lys
Ile Ile Glu Asn Gln Ser Lys 435 440 445 Tyr Tyr Pro Phe Leu Lys Glu
Ile Asn Pro Val Ser Ser His Leu Lys 450 455 460 Glu Ala Pro Tyr Lys
Leu Asp Glu Leu Ile Arg Phe Arg Val Pro Tyr 465 470 475 480 Tyr Val
Gly Pro Leu Ile Ser Pro Asn Glu Ser Thr Lys Asp Ile Gln 485 490 495
Thr Lys Lys Asn Gln Asn Phe Ala Trp Met Ile Arg Lys Glu Glu Gly 500
505 510 Arg Ile Thr Pro Trp Asn Phe Asp Gln Lys Val Asp Arg Ile Glu
Ser 515 520 525 Ala Asn Lys Phe Ile Lys Arg Met Thr Thr Lys Asp Thr
Tyr Leu Phe 530 535 540 Gly Glu Asp Val Leu Pro Ala Asn Ser Leu Leu
Tyr Gln Lys Phe Thr 545 550 555 560 Val Leu Asn Glu Leu Asn Asn Ile
Arg Ile Asn Gly Lys Arg Ile Ser 565 570 575 Val Asp Leu Lys Gln Glu
Ile Tyr Glu Asn Leu Phe Lys Lys His Thr 580 585 590 Thr Val Thr Val
Lys Lys Leu Glu Asn Tyr Leu Lys Glu Asn His Asn 595 600 605 Leu Val
Lys Val Glu Ile Lys Gly Leu Ala Asp Glu Lys Lys Phe Asn 610 615 620
Ser Gly Leu Thr Thr Tyr Asn Arg Phe Lys Asn Leu Asn Ile Phe Asp 625
630 635 640 Asn Gln Ile Asp Asp Leu Lys Tyr Arg Asn Asp Phe Glu Lys
Ile Ile 645 650 655 Glu Trp Ser Thr Ile Phe Glu Asp Lys Ser Ile Tyr
Lys Glu Lys Leu 660 665 670 Arg Ser Ile Asp Trp Leu Asn Glu Lys Gln
Ile Asn Ala Leu Ser Asn 675 680 685 Ile Arg Leu Gln Gly Trp Gly Arg
Leu Ser Lys Lys Leu Leu Ala Gln 690 695 700 Leu His Asp His Asn Gly
Gln Thr Ile Ile Glu Gln Leu Trp Asp Ser 705 710 715 720 Gln Asn Asn
Phe Met Gln Ile Val Thr Gln Ala Asp Phe Lys Asp Ala 725 730 735 Ile
Ala Lys Ala Asn Gln Asn Leu Leu Val Ala Thr Ser Val Glu Asp 740 745
750 Ile Leu Asn Asn Ala Tyr Thr Ser Pro Ala Asn Lys Lys Ala Ile Arg
755 760 765 Gln Val Ile Lys Val Val Asp Asp Ile Val Lys Ala Ala Ser
Gly Lys 770 775 780 Val Pro Lys Gln Ile Ala Ile Glu Phe Thr Arg Asp
Ala Asp Glu Asn 785 790 795 800 Pro Lys Arg Ser Gln Thr Arg Gly Ser
Lys Leu Gln Lys Val Tyr Lys 805 810 815 Asp Leu Ser Thr Glu Leu Ala
Ser Lys Thr Ile Ala Glu Glu Leu Asn 820 825 830 Glu Ala Ile Lys Asp
Lys Lys Leu Val Gln Asp Lys Tyr Tyr Leu Tyr 835 840 845 Phe Met Gln
Leu Gly Arg Asp Ala Tyr Thr Gly Glu Pro Ile Asn Ile 850 855 860 Asp
Glu Ile Gln Lys Tyr Asp Ile Asp His Ile Leu Pro Gln Ser Phe 865 870
875 880 Ile Lys Asp Asp Ala Leu Asp Asn Arg Val Leu Val Ser Arg Ala
Val 885 890 895 Asn Asn Gly Lys Ser Asp Asn Val Pro Val Lys Leu Phe
Gly Asn Glu 900 905 910 Met Ala Ala Asn Leu Gly Met Thr Ile Arg Lys
Met Trp Glu Glu Trp 915 920 925 Lys Asn Ile Gly Leu Ile Ser Lys Thr
Lys Tyr Asn Asn Leu Leu Thr 930 935 940 Asp Pro Asp His Ile Asn Lys
Tyr Lys Ser Ala Gly Phe Ile Arg Arg 945 950 955 960 Gln Leu Val Glu
Thr Ser Gln Ile Ile Lys Leu Val Ser Thr Ile Leu 965 970 975 Gln Ser
Arg Tyr Pro Asn Thr Glu Ile Ile Thr Val Lys Ala Lys Tyr 980 985 990
Asn His Tyr Leu Arg Glu Lys Phe Asp Leu Tyr Lys Ser Arg Glu Val 995
1000 1005 Asn Asp Tyr His His Ala Ile Asp Ala Tyr Leu Ser Ala Ile
Cys 1010 1015 1020 Gly Asn Leu Leu Tyr Gln Asn Tyr Pro Asn Leu Arg
Pro Phe Phe 1025 1030 1035 Val Tyr Gly Gln Tyr Lys Lys Phe Ser Ser
Asp Pro Asp Lys Glu 1040 1045 1050 Lys Ala Ile Phe Asn Lys Thr Arg
Lys Phe Ser Phe Ile Ser Gln 1055 1060 1065 Leu Leu Lys Asn Lys Ser
Glu Asn Ser Lys Glu Ile Ala Lys Lys 1070 1075 1080 Leu Lys Arg Ala
Tyr Gln Phe Lys Tyr Met Leu Val Ser Arg Glu 1085 1090 1095 Thr Glu
Thr Arg Asp Gln Glu Met Phe Lys Met Thr Val Tyr Pro 1100 1105 1110
Arg Phe Ser His Asp Thr Val Lys Ala Pro Arg Asn Leu Ile Pro 1115
1120 1125 Lys Lys Met Gly Met Ser Pro Asp Ile Tyr Gly Gly Tyr Thr
Asn 1130 1135 1140 Asn Ser Asp Ala Tyr Met Val Ile Val Arg Ile Asp
Lys Lys Lys 1145 1150 1155 Gly Thr Glu Tyr Lys Ile Leu Gly Ile Pro
Thr Arg Glu Leu Val 1160 1165 1170 Asn Leu Lys Lys Ala Glu Lys Glu
Asp His Tyr Lys Ser Tyr Leu 1175 1180 1185 Lys Glu Ile Leu Thr Pro
Arg Ile Leu Tyr Asn Lys Asn Gly Lys 1190 1195 1200 Arg Asp Lys Lys
Ile Thr Ser Phe Glu Ile Val Lys Ser Lys Ile 1205 1210 1215 Pro Tyr
Lys Gln Val Ile Gln Asp Gly Asp Lys Lys Phe Met Leu 1220 1225 1230
Gly Ser Ser Thr Tyr Val Tyr Asn Ala Lys Gln Leu Thr Leu Ser 1235
1240 1245 Thr Glu Ser Met Lys Ala Ile Thr Asn Asn Phe Asp Lys Asp
Ser 1250 1255 1260 Asp Glu Asn Asp Ala Leu Ile Lys Ala Tyr Asp Glu
Ile Leu Asp 1265 1270 1275 Lys Val Asp Lys Tyr Leu Pro Leu Phe Asp
Ile Asn Lys Phe Arg 1280 1285 1290 Glu Lys Leu His Ser Gly Arg Glu
Lys Phe Ile Lys Leu Ser Leu 1295 1300 1305 Glu Asp Lys Lys Asp Thr
Ile Leu Lys Val Leu Glu Gly Leu His 1310 1315 1320 Asp Asn Ala Val
Met Thr Lys Ile Pro Thr Ile Gly Leu Ser Thr 1325 1330 1335 Pro Leu
Gly Phe Met Gln Phe Pro Asn Gly Val Ile Leu Ser Glu 1340 1345 1350
Asn Ala Lys Leu Ile Tyr Gln Ser Pro Thr Gly Leu Phe Lys Lys 1355
1360 1365 Ser Val Lys Ile Ser Asp Leu 1370 1375
1784209DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 178accggtgcca ccatgtaccc atacgatgtt
ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag cgtccatgac aaaaatcaaa
gacgactaca tcgtgggact ggacatcggc 120acagactcct gcgggtgggt
ggctatgaac agcaataatg acattctgaa actgcagggc 180aagaccgcaa
tcgggtcacg cctgttcgag ggagggaaga gcgcagctga acggagactg
240tttcgcacca cacacaggcg catcaaacga cggagatggc gactgaagct
gctggaggag 300ttcttcgacc cctacatggc agaggtggat ccttatttct
ttgcccggct gaaggaatct 360ggcctgagtc cactggacaa aagaaagacc
gtgagctcca ttgtgttccc cacatccgcc 420gaggataaga agttctacga
cgattaccct acaatctacc atctgaggta taaactgatg 480actgaggacg
aaaagttcga tctgcgcgaa gtgtacctgg ctatccacca tatcattaag
540taccgaggaa acttcctgta taataccagt gtgaaagact tcaaggcatc
aaagatcgat 600gtcaaatcta gtatcgagaa gctgaacgag ctgtatgaaa
atctgggcct ggacctgaac 660gtggagttca acattagcaa tactgccgag
atcgaaaagg tgctgaaaga caagcagatc 720ttcaagcggg ataaagtcaa
gaaaattgcc gagctgtttg ctatcaaaac cgacaacaag 780gaacagagca
agagaatcaa agatatttcc aaacaggtgg ccaatgctgt cctggggtac
840aagaccaggt tcgacacaat cgctctgaaa gagatttcca aggacgaact
gtctgattgg 900aacttcaaac tgtcagacat cgatgcagac agcaagtttg
aggccctgat gggaaacctg 960gatgagaatg aacaggccat cctgctgact
attaaggagc tgtttaacga agtgaccctg 1020aatggaattg tcgaggacgg
caacaccctg agcgaatcca tgatcaacaa gtacaatgat 1080caccgggacg
atctgaagct gctgaaagaa gtgatcgaaa atcatattga cagaaagaaa
1140gccaaggagc tggcactggc ctacgatctg tatgtcaaca ataggcacgg
acagctgctg 1200caggctaaga aaaagctggg caaaatcaag ccccgctcta
aggaggactt ctacaaagtg 1260gtcaacaaga atctggacga ttcacgggca
agcaaggaga tcaaaaagaa aattgaactg 1320gacagcttta tgcctaagca
gagaaccaac gccaatggcg tgatcccata ccagctgcag 1380cagctggagc
tggataagat catcgaaaac cagtctaagt actatccatt cctgaaggag
1440attaatcccg tgtcaagcca cctgaaagag gccccctata agctggacga
actgatccga 1500tttcgggtgc cttactatgt cggccccctg atttctccta
acgagagtac caaggatatc 1560cagacaaaga aaaaccagaa tttcgcctgg
atgattcgca aagaggaagg gcgaatcaca 1620ccttggaact ttgaccagaa
ggtggatcga attgagagcg ccaataagtt catcaaacgg 1680atgactacca
aggacactta cctgtttggg gaggatgtgc tgccagctaa cagcctgctg
1740tatcagaagt tcaccgtcct gaacgaactg aacaacatcc ggattaatgg
aaaaagaatc 1800tccgtggacc tgaagcagga gatctacgaa aacctgttta
agaaacacac aactgtgacc 1860gtcaagaaac tggagaatta tctgaaggaa
aaccataatc tggtgaaagt cgagatcaag 1920gggctggccg atgaaaagaa
attcaacagc ggactgacca catacaatag attcaagaac 1980ctgaacatct
ttgacaacca gattgacgat ctgaagtaca ggaacgattt cgagaagatc
2040atcgaatggt ctacaatttt tgaggacaag agtatctaca aagaaaagct
gaggagcatc 2100gattggctga acgagaagca gattaacgct ctgtctaata
tcagactgca ggggtgggga 2160aggctgagta agaaactgct ggcacagctg
cacgaccata atggccagac catcattgag 2220cagctgtggg attcccagaa
caatttcatg cagattgtga cacaggccga ctttaaagat 2280gctatcgcaa
aggccaacca gaatctgctg gtggctacct cagtcgagga cattctgaac
2340aatgcataca caagccccgc aaacaagaaa gccatcagac aggtcatcaa
ggtggtcgac 2400gatatcgtga aggcagcctc cggaaaggtc ccaaaacaga
tcgccattga gttcactagg 2460gatgctgacg aaaatcccaa gagaagtcag
accaggggct caaagctgca gaaagtgtac 2520aaggacctga gcactgagct
ggcctccaag accattgctg aggaactgaa cgaagcaatc 2580aaagacaaga
aactggtgca ggataagtac tatctgtact ttatgcagct ggggcgggac
2640gcctatacag gagagcctat caatatcgat gaaatccaga agtacgatat
cgaccacatt 2700ctgccacagt ctttcatcaa ggacgatgcc ctggacaaca
gggtgctggt gagccgggct 2760gtgaacaatg gcaaatctga taatgtgcct
gtcaagctgt ttggcaacga gatggctgca 2820aatctgggga tgactatcag
gaaaatgtgg gaggaatgga agaacatcgg cctgattagc 2880aaaacaaagt
acaacaatct gctgactgat cccgaccaca ttaacaagta taagagtgcc
2940gggttcatca ggcgccagct ggtggagaca tcacagatca tcaagctggt
gagcactatc 3000ctgcagagtc gctaccctaa cactgaaatc attaccgtga
aggctaagta caatcattat 3060ctgcgggaga aatttgacct gtataagagc
agagaagtca acgactacca ccatgctatt 3120gatgcatatc tgtccgccat
ctgcggaaat ctgctgtacc agaactatcc aaatctgcgg 3180cccttctttg
tgtacggcca gtataagaaa ttctcctctg atcctgacaa agagaaggcc
3240atttttaaca aaacccgcaa gttctccttt atctctcagc tgctgaaaaa
caagagtgag 3300aacagcaagg aaatcgctaa gaaactgaaa cgggcatacc
agttcaagta tatgctggtg 3360tctcgagaga ctgaaacccg ggaccaggag
atgttcaaaa tgaccgtgta cccccggttc 3420agccacgata cagtcaaggc
tcctaggaac ctgattccaa agaaaatggg catgtcccct 3480gacatctacg
gaggctatac aaacaattct gacgcataca tggtcatcgt ccgcattgat
3540aagaaaaagg gaactgagta taagatcctg ggcattccaa cccgggaact
ggtgaatctg 3600aaaaaggccg agaaggagga ccattacaaa agctatctga
aggagatcct gacaccaagg 3660attctgtaca acaaaaatgg gaagcgcgat
aaaaagatca cttccttcga aattgtgaaa 3720tctaagatcc cctataagca
ggtcatccag gatggggaca aaaagtttat gctgggaagt 3780tcaacatacg
tgtataacgc aaagcagctg acactgagca ctgagtccat gaaagccatc
3840actaacaatt tcgataagga cagcgatgag aacgacgctc tgattaaggc
atacgatgaa 3900atcctggaca aagtggataa gtatctgcca ctgttcgaca
tcaacaagtt ccgggagaag 3960ctgcacagtg ggcgagaaaa gttcatcaag
ctgagcctgg aggacaaaaa ggataccatc 4020ctgaaagtgc tggaaggact
gcatgataac gctgtcatga caaagatccc tactattggc 4080ctgtccacac
cactggggtt catgcagttt cccaacggcg tgattctgag cgagaatgcc
4140aaactgatct accagtcccc caccgggctg ttcaaaaagt cagtgaagat
cagcgacctg 4200taagaattc 4209179178RNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
179nnnnnnnnnn nnnnnnnnnn guuguagcuc ccauucucga aagagaaccg
uugcuacaau 60aaggccgucu gaaaagaugu gccgcaacgc ucugccccuu aaagcuucug
cuuuaagggg 120caucguuuau uucgguuaaa aaugccgucu gaaaccgguu
uuuagguuuc agacggca 1781801082PRTNeisseria cinerea 180Met Ala Ala
Phe Lys Pro Asn Pro Met Asn Tyr Ile Leu Gly Leu Asp 1 5 10 15 Ile
Gly Ile Ala Ser Val Gly Trp Ala Ile Val Glu Ile Asp Glu Glu 20 25
30 Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg
35 40 45 Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg
Arg Leu 50 55 60 Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala
His Arg Leu Leu 65 70 75 80 Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly
Val Leu Gln Ala Ala Asp 85 90 95 Phe Asp Glu Asn Gly Leu Ile Lys
Ser Leu Pro Asn Thr Pro Trp Gln 100 105 110 Leu Arg Ala Ala Ala Leu
Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 115 120 125 Ala Val Leu Leu
His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 130 135 140 Lys Asn
Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 145 150 155
160 Gly Val Ala Asp Asn Thr His Ala Leu Gln Thr Gly Asp Phe Arg Thr
165 170 175 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly
His Ile 180 185 190 Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Asn
Arg Lys Asp Leu 195 200 205 Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys
Gln Lys Glu Phe Gly Asn 210 215 220 Pro His Val Ser Asp Gly Leu Lys
Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gln Arg Pro Ala
Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 245 250 255 His Cys Thr
Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr
Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280
285 Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr
290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala
Gln Ala 305 310 315 320 Arg Lys Leu Leu Asp Leu Asp Asp Thr Ala Phe
Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser
Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala
Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn
Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser
Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400
Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405
410 415 Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile
Val 420 425 430 Pro Leu Met Glu Gln Gly Asn Arg Tyr Asp Glu Ala Cys
Thr Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu
Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg
Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gln Ala Arg Lys
Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg
Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys
Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 515 520 525
Asp Arg Glu Lys Ser Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530
535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr
Glu 545 550 555 560 Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu
Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile
Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe
Asn Asn Lys Val Leu Ala Leu Gly 595 600 605 Ser Glu Asn Gln Asn Lys
Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn
Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr
Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 645 650
655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr
660 665 670 Ile Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Met Leu
Leu Thr 675 680 685 Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly
Gln Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys
Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala
Val Val Val Ala Cys Ser Thr Ile Ala 725 730 735 Met Gln Gln Lys Ile
Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Phe Asp Gly
Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 755 760 765 Lys
Ala His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 770 775
780 Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala
785 790 795 800 Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys
Leu Ser Ser 805 810 815 Arg Pro Glu Ala Val His Lys Tyr Val Thr Pro
Leu Phe Ile Ser Arg 820 825 830 Ala Pro Asn Arg Lys Met Ser Gly Gln
Gly His Met Glu Thr Val Lys 835 840 845 Ser Ala Lys Arg Leu Asp Glu
Gly Ile Ser Val Leu Arg Val Pro Leu 850 855 860 Thr Gln Leu Lys Leu
Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 865 870 875 880 Glu Pro
Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 885 890 895
Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 900
905 910 Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln
Val 915 920 925 Gln Lys Thr Gly Val Trp Val His Asn His Asn Gly Ile
Ala Asp Asn 930 935 940 Ala Thr Ile Val Arg Val Asp Val Phe Glu Lys
Gly Gly Lys Tyr Tyr 945 950 955 960 Leu Val Pro Ile Tyr Ser Trp Gln
Val Ala Lys Gly Ile Leu Pro Asp 965 970 975 Arg Ala Val Val Gln Gly
Lys Asp Glu Glu Asp Trp Thr Val Met Asp 980 985 990 Asp Ser Phe Glu
Phe Lys Phe Val Leu Tyr Ala Asn Asp Leu Ile Lys 995 1000 1005 Leu
Thr Ala Lys Lys Asn Glu Phe Leu Gly Tyr Phe Val Ser Leu 1010 1015
1020 Asn Arg Ala Thr Gly Ala Ile Asp Ile Arg Thr His Asp Thr Asp
1025 1030 1035 Ser Thr Lys Gly Lys Asn Gly Ile Phe Gln Ser Val Gly
Val Lys 1040 1045 1050 Thr Ala Leu Ser Phe Gln Lys Tyr Gln Ile Asp
Glu Leu Gly Lys 1055 1060 1065 Glu Ile Arg Pro Cys Arg Leu Lys Lys
Arg Pro Pro Val Arg 1070 1075 1080 1813330DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
181accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtccatggc tgccttcaaa cctaatccta tgaactacat
cctgggcctg 120gacattggaa tcgcttctgt cgggtgggct atcgtggaaa
tcgacgagga agagaaccct 180atcagactga ttgatctggg agtcagagtg
tttgaaaggg cagaggtgcc aaagaccggc 240gactccctgg ccgctgcacg
gagactggct cggtctgtca ggcgcctgac acgacggaga 300gcacacaggc
tgctgcgagc taggcgcctg ctgaagagag agggcgtgct gcaggccgct
360gacttcgatg aaaacggcct gatcaagagc ctgcccaata ctccttggca
gctgagagca 420gccgctctgg acaggaagct gaccccactg gagtggtctg
ccgtgctgct gcacctgatc 480aagcatcgcg gctacctgag tcagcgaaaa
aatgaagggg agacagcaga taaggagctg 540ggagcactgc tgaaaggagt
ggccgacaac actcatgctc tgcagaccgg cgattttagg 600acacccgctg
agctggcact gaataagttc gaaaaagaga gtggacacat tcgaaaccag
660cggggcgact attcacatac cttcaaccgc aaggatctgc aggccgagct
gaatctgctg 720tttgaaaagc agaaagagtt cgggaatccc cacgtgtccg
acgggctgaa agaaggaatc 780gagacactgc tgatgactca gaggcctgca
ctgtctggcg atgccgtgca gaagatgctg 840gggcattgca cctttgaacc
aacagagccc aaggcagcca aaaacaccta cacagccgag 900aggttcgtgt
ggctgacaaa gctgaacaat ctgcgcatcc tggaacaggg cagtgagcgg
960cccctgactg acaccgaaag agccacactg atggatgagc cttacaggaa
gtctaaactg 1020acttatgccc aggctcgcaa gctgctggac ctggacgata
ctgccttctt taagggcctg 1080aggtacggga aagataatgc agaagccagc
accctgatgg agatgaaggc ctatcacgct 1140atctcccgcg ccctggaaaa
agagggcctg aaggacaaga aatctcccct gaacctgagt 1200cctgaactgc
aggatgagat tgggaccgct tttagcctgt tcaagactga cgaggatatc
1260accggacgcc tgaaagaccg agtgcagccc gaaattctgg aggcactgct
gaagcacatc 1320agttttgata aattcgtgca gatttcactg aaggccctgc
gacggatcgt ccctctgatg 1380gagcagggca atcggtacga cgaggcctgc
accgagatct acggagatca ttatggcaag 1440aaaaacacag aagagaaaat
ctatctgccc cctattcctg ccgacgagat ccggaatcca 1500gtggtcctga
gagctctgtc acaggcaaga aaagtgatca acggagtggt cagaaggtac
1560ggcagccctg ctaggatcca cattgaaacc gcacgcgaag tgggaaagtc
ctttaaagac 1620cgcaaggaaa tcgagaagcg acaggaagag aatagaaaag
atagggaaaa gtctgctgca 1680aaattcaggg agtactttcc aaacttcgtg
ggcgaaccca agagtaaaga catcctgaag 1740ctgcgcctgt acgagcagca
gcacgggaag tgtctgtata gcggaaaaga aattaacctg 1800ggccggctga
atgaaaaggg ctatgtggag atcgatcatg cactgccctt ttccagaaca
1860tgggacgatt ctttcaacaa taaggtcctg gctctgggga gcgagaacca
gaacaaggga 1920aatcagactc cttacgaata tttcaacggg aaggacaata
gccgagaatg gcaggagttt 1980aaagcccgcg tggagacaag ccggttccca
cgaagcaaga aacagcggat tctgctgcag 2040aagtttgacg aagatggatt
caaagagaga aacctgaatg acacccggta catcaacaga 2100tttctgtgcc
agttcgtggc tgatcacatg ctgctgaccg gaaagggcaa acgccgagtc
2160tttgcaagca acggccagat cacaaatctg ctgaggggct tctgggggct
gcggaaggtg 2220agagccgaga atgaccgcca ccatgcactg gatgccgtgg
tcgtggcttg ttccactatt 2280gcaatgcagc agaagatcac caggtttgtg
cgctataaag agatgaacgc cttcgacgga 2340aagacaattg ataaagaaac
tggcgaggtg ctgcaccaga aggcacattt tcctcagcca 2400tgggagttct
tcgcccagga agtgatgatc cgggtctttg ggaagcctga cggaaaacca
2460gagttcgaag aggccgatac cccagaaaag ctgcggacac tgctggctga
aaaactgagc 2520tccagacccg aggcagtgca caagtacgtc acccccctgt
tcattagcag ggcccctaat 2580cgcaaaatgt ccgggcaggg acatatggag
actgtgaaat cagctaagcg gctggacgaa 2640ggcatcagcg tgctgagagt
cccactgacc cagctgaagc tgaaagatct ggagaagatg 2700gtgaaccggg
aaagagagcc caagctgtat gaagctctga aagcaagact ggaggcccac
2760aaggacgatc cagctaaagc atttgccgag cccttctaca aatatgacaa
ggccggcaat 2820cggacacagc aggtgaaggc tgtcagagtg gagcaggtcc
agaaaactgg ggtctgggtg 2880cacaaccata atggaattgc cgacaacgct
acaatcgtcc gggtggatgt gttcgagaaa 2940ggcgggaagt actatctggt
gcctatctac tcctggcagg tcgccaaggg aatcctgcca 3000gatagagctg
tcgtgcaggg caaagacgaa gaggattgga ctgtgatgga cgattctttc
3060gagtttaagt tcgtcctgta cgcaaacgac ctgatcaagc tgacagccaa
gaaaaatgaa 3120tttctggggt atttcgtgtc actgaacagg gcaactggag
ccatcgatat tcgcacacat 3180gacactgata gcaccaaggg aaaaaacggc
atctttcagt ctgtgggcgt caagaccgcc 3240ctgagtttcc agaaatatca
gattgacgaa ctggggaagg agatccgacc ctgtcggctg 3300aagaaacgac
cacccgtgcg gtaagaattc 3330182145RNAArtificial SequenceDescription
of Artificial Sequence Synthetic polynucleotide 182nnnnnnnnnn
nnnnnnnnnn gcugcggauu gcgggaaauc gcuuuucgca agcaaauuga 60ccccuugugc
gggcucggca ucccaagguc agcugccggu uauuaucgaa aaggcccacc
120gcaagcagcg cgugggccuu uuuuu 1451831037PRTParvibaculum
lavamentivorans 183Met Glu Arg Ile Phe Gly Phe Asp Ile Gly Thr Thr
Ser Ile Gly Phe 1 5 10 15 Ser Val Ile Asp Tyr Ser Ser Thr Gln Ser
Ala Gly Asn Ile Gln Arg 20 25 30 Leu Gly Val Arg Ile Phe Pro Glu
Ala Arg Asp Pro Asp Gly Thr Pro 35 40 45 Leu Asn Gln Gln Arg Arg
Gln Lys Arg Met Met Arg Arg Gln Leu Arg 50 55 60 Arg Arg Arg Ile
Arg Arg Lys Ala Leu Asn Glu Thr Leu His Glu Ala 65 70 75 80 Gly Phe
Leu Pro Ala Tyr Gly Ser Ala Asp Trp Pro Val Val Met Ala 85 90 95
Asp Glu Pro Tyr Glu Leu Arg Arg Arg Gly Leu Glu Glu Gly Leu Ser 100
105 110 Ala Tyr Glu Phe Gly Arg Ala Ile Tyr His Leu Ala Gln His Arg
His 115 120 125 Phe Lys Gly Arg Glu Leu Glu Glu Ser Asp Thr Pro Asp
Pro Asp Val 130 135 140 Asp Asp Glu Lys Glu Ala Ala Asn Glu Arg Ala
Ala Thr Leu Lys Ala 145 150 155 160 Leu Lys Asn Glu Gln Thr Thr Leu
Gly Ala Trp Leu Ala Arg Arg Pro 165 170 175 Pro Ser Asp Arg Lys Arg
Gly Ile His Ala His Arg Asn Val Val Ala 180 185 190 Glu Glu Phe Glu
Arg Leu Trp Glu Val Gln Ser Lys Phe His Pro Ala 195 200 205 Leu Lys
Ser Glu Glu Met Arg Ala Arg Ile Ser Asp Thr Ile Phe Ala 210 215 220
Gln Arg Pro Val Phe Trp Arg Lys Asn Thr Leu Gly Glu Cys Arg Phe 225
230 235 240 Met Pro Gly Glu Pro Leu Cys Pro Lys Gly Ser Trp Leu Ser
Gln Gln 245 250 255 Arg Arg Met Leu Glu Lys Leu Asn Asn Leu Ala Ile
Ala Gly Gly Asn 260 265 270 Ala Arg Pro Leu Asp Ala Glu Glu Arg Asp
Ala Ile Leu Ser Lys Leu 275 280 285 Gln Gln Gln Ala Ser Met Ser Trp
Pro Gly Val Arg Ser Ala Leu Lys 290 295 300 Ala Leu Tyr Lys Gln Arg
Gly Glu Pro Gly Ala Glu Lys Ser Leu Lys 305 310 315 320 Phe Asn Leu
Glu Leu Gly Gly Glu Ser Lys Leu Leu Gly Asn Ala Leu 325 330 335 Glu
Ala Lys Leu Ala Asp Met Phe Gly Pro Asp Trp Pro Ala His Pro 340 345
350 Arg Lys Gln Glu Ile Arg His Ala Val His Glu Arg Leu Trp Ala Ala
355 360 365 Asp Tyr Gly Glu Thr Pro Asp Lys Lys Arg Val Ile Ile Leu
Ser Glu 370 375 380 Lys Asp Arg Lys Ala His Arg Glu Ala Ala Ala Asn
Ser Phe Val Ala 385 390 395 400 Asp Phe Gly Ile Thr Gly Glu Gln Ala
Ala Gln Leu Gln Ala Leu Lys 405 410 415 Leu Pro Thr Gly Trp Glu Pro
Tyr Ser Ile Pro Ala Leu Asn Leu Phe 420 425 430 Leu Ala Glu Leu Glu
Lys Gly Glu Arg Phe Gly Ala Leu Val Asn Gly 435 440 445 Pro Asp Trp
Glu Gly Trp Arg Arg Thr Asn Phe Pro His Arg Asn Gln 450 455 460 Pro
Thr Gly Glu Ile Leu Asp Lys Leu Pro Ser Pro Ala Ser Lys Glu 465 470
475 480 Glu Arg Glu Arg Ile Ser Gln Leu Arg Asn Pro Thr Val Val Arg
Thr 485 490 495 Gln Asn Glu Leu Arg Lys Val Val Asn Asn Leu Ile Gly
Leu Tyr Gly 500 505 510 Lys Pro Asp Arg Ile Arg Ile Glu Val Gly Arg
Asp Val Gly Lys Ser 515 520 525 Lys Arg Glu Arg Glu Glu Ile Gln Ser
Gly Ile Arg Arg Asn Glu Lys 530 535 540 Gln Arg Lys Lys Ala Thr Glu
Asp Leu Ile Lys Asn Gly Ile Ala Asn 545 550 555 560 Pro Ser Arg Asp
Asp Val Glu Lys Trp Ile Leu Trp Lys Glu Gly Gln 565 570 575 Glu Arg
Cys Pro Tyr Thr Gly Asp Gln Ile Gly Phe Asn Ala
Leu Phe 580 585 590 Arg Glu Gly Arg Tyr Glu Val Glu His Ile Trp Pro
Arg Ser Arg Ser 595 600 605 Phe Asp Asn Ser Pro Arg Asn Lys Thr Leu
Cys Arg Lys Asp Val Asn 610 615 620 Ile Glu Lys Gly Asn Arg Met Pro
Phe Glu Ala Phe Gly His Asp Glu 625 630 635 640 Asp Arg Trp Ser Ala
Ile Gln Ile Arg Leu Gln Gly Met Val Ser Ala 645 650 655 Lys Gly Gly
Thr Gly Met Ser Pro Gly Lys Val Lys Arg Phe Leu Ala 660 665 670 Lys
Thr Met Pro Glu Asp Phe Ala Ala Arg Gln Leu Asn Asp Thr Arg 675 680
685 Tyr Ala Ala Lys Gln Ile Leu Ala Gln Leu Lys Arg Leu Trp Pro Asp
690 695 700 Met Gly Pro Glu Ala Pro Val Lys Val Glu Ala Val Thr Gly
Gln Val 705 710 715 720 Thr Ala Gln Leu Arg Lys Leu Trp Thr Leu Asn
Asn Ile Leu Ala Asp 725 730 735 Asp Gly Glu Lys Thr Arg Ala Asp His
Arg His His Ala Ile Asp Ala 740 745 750 Leu Thr Val Ala Cys Thr His
Pro Gly Met Thr Asn Lys Leu Ser Arg 755 760 765 Tyr Trp Gln Leu Arg
Asp Asp Pro Arg Ala Glu Lys Pro Ala Leu Thr 770 775 780 Pro Pro Trp
Asp Thr Ile Arg Ala Asp Ala Glu Lys Ala Val Ser Glu 785 790 795 800
Ile Val Val Ser His Arg Val Arg Lys Lys Val Ser Gly Pro Leu His 805
810 815 Lys Glu Thr Thr Tyr Gly Asp Thr Gly Thr Asp Ile Lys Thr Lys
Ser 820 825 830 Gly Thr Tyr Arg Gln Phe Val Thr Arg Lys Lys Ile Glu
Ser Leu Ser 835 840 845 Lys Gly Glu Leu Asp Glu Ile Arg Asp Pro Arg
Ile Lys Glu Ile Val 850 855 860 Ala Ala His Val Ala Gly Arg Gly Gly
Asp Pro Lys Lys Ala Phe Pro 865 870 875 880 Pro Tyr Pro Cys Val Ser
Pro Gly Gly Pro Glu Ile Arg Lys Val Arg 885 890 895 Leu Thr Ser Lys
Gln Gln Leu Asn Leu Met Ala Gln Thr Gly Asn Gly 900 905 910 Tyr Ala
Asp Leu Gly Ser Asn His His Ile Ala Ile Tyr Arg Leu Pro 915 920 925
Asp Gly Lys Ala Asp Phe Glu Ile Val Ser Leu Phe Asp Ala Ser Arg 930
935 940 Arg Leu Ala Gln Arg Asn Pro Ile Val Gln Arg Thr Arg Ala Asp
Gly 945 950 955 960 Ala Ser Phe Val Met Ser Leu Ala Ala Gly Glu Ala
Ile Met Ile Pro 965 970 975 Glu Gly Ser Lys Lys Gly Ile Trp Ile Val
Gln Gly Val Trp Ala Ser 980 985 990 Gly Gln Val Val Leu Glu Arg Asp
Thr Asp Ala Asp His Ser Thr Thr 995 1000 1005 Thr Arg Pro Met Pro
Asn Pro Ile Leu Lys Asp Asp Ala Lys Lys 1010 1015 1020 Val Ser Ile
Asp Pro Ile Gly Arg Val Arg Pro Ser Asn Asp 1025 1030 1035
1843195DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 184accggtgcca ccatgtaccc atacgatgtt
ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag cgtccatgga gaggattttc
ggctttgaca tcggcacaac aagtatcgga 120ttcagcgtga ttgattacag
tagcacccag tccgcaggca acatccagag gctgggcgtg 180cgcattttcc
ctgaggcaag ggacccagat gggacccccc tgaaccagca gcggagacag
240aaacgcatga tgaggcgcca gctgcgacgg agaaggattc gccgaaaggc
actgaatgag 300acactgcacg aagccggctt tctgccagct tacgggtctg
cagattggcc cgtggtcatg 360gccgacgagc cttatgaact gcggagaagg
ggactggagg aaggcctgag tgcttacgag 420ttcggacggg caatctatca
tctggcccag caccggcatt ttaaaggcag agaactggag 480gaatccgata
cacccgaccc tgatgtggac gatgagaagg aagccgctaa cgagagagca
540gccactctga aggccctgaa aaatgaacag accacactgg gagcatggct
ggcccgccga 600cccccttctg accgcaagcg aggaatccac gcccatagga
acgtggtcgc tgaggagttc 660gagcgcctgt gggaagtgca gtccaagttt
caccccgctc tgaaatctga ggaaatgcgg 720gcaagaatca gtgatacaat
tttcgcccag aggcctgtgt tttggcgcaa gaacactctg 780ggagagtgca
gattcatgcc tggcgaacca ctgtgtccca aggggtcctg gctgtctcag
840cagcggagaa tgctggagaa actgaacaat ctggctatcg caggcgggaa
tgctaggcca 900ctggatgcag aggaacgcga cgccattctg agtaagctgc
agcagcaggc cagcatgtcc 960tggccaggcg tgcggtcagc tctgaaggca
ctgtacaaac agagaggcga gcccggggct 1020gaaaagagcc tgaaattcaa
cctggagctg ggaggcgaat ccaagctgct gggaaatgcc 1080ctggaggcta
aactggcaga tatgtttggc cctgactggc cagctcaccc ccgaaagcag
1140gagatccggc acgcagtgca tgaacggctg tgggctgcag attacggcga
gacacccgac 1200aagaaaagag tcatcattct gtccgagaag gatcgaaaag
ctcatcggga agccgctgca 1260aactctttcg tggcagactt tggaattact
ggcgagcagg cagctcagct gcaggccctg 1320aagctgccaa ccggctggga
accttatagc atcccagcac tgaacctgtt cctggccgag 1380ctggaaaagg
gggagaggtt tggagccctg gtgaatggac ctgattggga aggctggagg
1440cgcacaaact tcccccaccg caatcagcct actggggaga tcctggacaa
gctgccaagt 1500cccgcctcaa aagaggaaag ggaacgcatt agccagctgc
gcaacccaac cgtggtccga 1560acacagaatg agctgagaaa ggtggtcaac
aatctgatcg ggctgtatgg aaaacccgat 1620cgaatccgga ttgaagtggg
ccgggacgtc gggaagtcca aaagagaaag ggaggaaatc 1680cagtctggca
ttcgacggaa cgagaagcag agaaagaaag ccactgaaga tctgatcaaa
1740aacggaattg ctaatcctag ccgggacgat gtggagaagt ggatcctgtg
gaaagagggc 1800caggaaagat gcccatacac cggcgaccag attggcttca
atgccctgtt tagagaaggc 1860agatatgagg tggaacacat ctggcctcgc
tctcgaagtt ttgataacag cccaaggaat 1920aagacactgt gtcgcaaaga
cgtgaacatc gagaagggaa ataggatgcc tttcgaggca 1980tttggccatg
acgaagatcg gtggagcgcc atccagatta gactgcaggg catggtgtca
2040gccaaagggg gaactgggat gagccccgga aaggtcaaac gcttcctggc
taagaccatg 2100cctgaggatt ttgcagcccg gcagctgaac gacacaagat
acgctgcaaa gcagatcctg 2160gcccagctga aaaggctgtg gccagacatg
ggacctgagg ctccagtgaa ggtcgaagca 2220gtgactggac aggtcaccgc
ccagctgcgc aaactgtgga ctctgaacaa tattctggct 2280gacgatgggg
agaaaaccag agcagatcac aggcaccatg ccatcgacgc tctgacagtg
2340gcctgcactc atcctggaat gaccaacaag ctgagcaggt attggcagct
gcgcgacgat 2400ccacgagcag agaagccagc tctgactcca ccctgggata
ccatccgcgc cgacgctgag 2460aaagccgtgt ctgaaattgt ggtcagtcac
cgggtgagaa agaaagtcag cggcccactg 2520cataaggaga ctacctacgg
cgatacaggg actgacatta agaccaaatc cggcacatat 2580agacagttcg
tgaccaggaa gaaaatcgag tcactgagca agggggagct ggatgaaatt
2640cgcgaccccc gaatcaaaga aattgtggca gctcacgtcg caggacgagg
aggcgacccc 2700aagaaggcct tccctccata cccctgtgtg tctcccggag
gccctgagat ccggaaggtc 2760agactgacca gtaaacagca gctgaacctg
atggcccaga cagggaatgg atacgctgac 2820ctgggctcca accaccatat
cgcaatctac cggctgcccg atgggaaggc cgacttcgag 2880attgtgtcac
tgtttgatgc tagcagaagg ctggcacaga gaaatccaat cgtgcagagg
2940acacgagcag acggagccag cttcgtcatg tccctggcag ccggagaggc
catcatgatt 3000cccgaaggct caaagaaagg gatctggatt gtgcagggag
tctgggcaag cggacaggtg 3060gtcctggaga gggacaccga tgctgaccac
tctacaacta cccgccctat gccaaacccc 3120atcctgaagg acgatgccaa
gaaagtgagt atcgatccta ttggccgagt ccggccatca 3180aatgactaag aattc
3195185103RNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 185nnnnnnnnnn nnnnnnnnnn guuuuaguac
ucuggaaaca gaaucuacua aaacaaggca 60aaaugccgug uuuaucucgu caacuuguug
gcgagauuuu uuu 1031861053PRTStaphylococcus aureus 186Met Lys Arg
Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 1 5 10 15 Gly
Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 20 25
30 Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg
35 40 45 Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His
Arg Ile 50 55 60 Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu
Leu Thr Asp His 65 70 75 80 Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu
Ala Arg Val Lys Gly Leu 85 90 95 Ser Gln Lys Leu Ser Glu Glu Glu
Phe Ser Ala Ala Leu Leu His Leu 100 105 110 Ala Lys Arg Arg Gly Val
His Asn Val Asn Glu Val Glu Glu Asp Thr 115 120 125 Gly Asn Glu Leu
Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 130 135 140 Leu Glu
Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 145 150 155
160 Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr
165 170 175 Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr
His Gln 180 185 190 Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu
Leu Glu Thr Arg 195 200 205 Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly
Ser Pro Phe Gly Trp Lys 210 215 220 Asp Ile Lys Glu Trp Tyr Glu Met
Leu Met Gly His Cys Thr Tyr Phe 225 230 235 240 Pro Glu Glu Leu Arg
Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 245 250 255 Asn Ala Leu
Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 260 265 270 Glu
Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 275 280
285 Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu
290 295 300 Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr
Gly Lys 305 310 315 320 Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp
Ile Lys Asp Ile Thr 325 330 335 Ala Arg Lys Glu Ile Ile Glu Asn Ala
Glu Leu Leu Asp Gln Ile Ala 340 345 350 Lys Ile Leu Thr Ile Tyr Gln
Ser Ser Glu Asp Ile Gln Glu Glu Leu 355 360 365 Thr Asn Leu Asn Ser
Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 370 375 380 Asn Leu Lys
Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 385 390 395 400
Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 405
410 415 Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser
Gln 420 425 430 Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile
Leu Ser Pro 435 440 445 Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys
Val Ile Asn Ala Ile 450 455 460 Ile Lys Lys Tyr Gly Leu Pro Asn Asp
Ile Ile Ile Glu Leu Ala Arg 465 470 475 480 Glu Lys Asn Ser Lys Asp
Ala Gln Lys Met Ile Asn Glu Met Gln Lys 485 490 495 Arg Asn Arg Gln
Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 500 505 510 Gly Lys
Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 515 520 525
Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 530
535 540 Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile
Pro 545 550 555 560 Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys
Val Leu Val Lys 565 570 575 Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg
Thr Pro Phe Gln Tyr Leu 580 585 590 Ser Ser Ser Asp Ser Lys Ile Ser
Tyr Glu Thr Phe Lys Lys His Ile 595 600 605 Leu Asn Leu Ala Lys Gly
Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 610 615 620 Tyr Leu Leu Glu
Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 625 630 635 640 Phe
Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 645 650
655 Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys
660 665 670 Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg
Lys Trp 675 680 685 Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His
His Ala Glu Asp 690 695 700 Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile
Phe Lys Glu Trp Lys Lys 705 710 715 720 Leu Asp Lys Ala Lys Lys Val
Met Glu Asn Gln Met Phe Glu Glu Lys 725 730 735 Gln Ala Glu Ser Met
Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 740 745 750 Ile Phe Ile
Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 755 760 765 Tyr
Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 770 775
780 Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu
785 790 795 800 Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn
Asp Lys Leu 805 810 815 Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu
Leu Met Tyr His His 820 825 830 Asp Pro Gln Thr Tyr Gln Lys Leu Lys
Leu Ile Met Glu Gln Tyr Gly 835 840 845 Asp Glu Lys Asn Pro Leu Tyr
Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 850 855 860 Leu Thr Lys Tyr Ser
Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 865 870 875 880 Lys Tyr
Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 885 890 895
Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 900
905 910 Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr
Val 915 920 925 Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu
Val Asn Ser 930 935 940 Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys
Ile Ser Asn Gln Ala 945 950 955 960 Glu Phe Ile Ala Ser Phe Tyr Asn
Asn Asp Leu Ile Lys Ile Asn Gly 965 970 975 Glu Leu Tyr Arg Val Ile
Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 980 985 990 Glu Val Asn Met
Ile Asp Ile Thr Tyr Arg Glu Tyr Leu Glu Asn Met 995 1000 1005 Asn
Asp Lys Arg Pro Pro Arg Ile Ile Lys Thr Ile Ala Ser Lys 1010 1015
1020 Thr Gln Ser Ile Lys Lys Tyr Ser Thr Asp Ile Leu Gly Asn Leu
1025 1030 1035 Tyr Glu Val Lys Ser Lys Lys His Pro Gln Ile Ile Lys
Lys Gly 1040 1045 1050 1873243DNAArtificial SequenceDescription of
Artificial Sequence Synthetic polynucleotide 187accggtgcca
ccatgtaccc atacgatgtt ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag
cgtccatgaa aaggaactac attctggggc tggacatcgg gattacaagc
120gtggggtatg ggattattga ctatgaaaca agggacgtga tcgacgcagg
cgtcagactg 180ttcaaggagg ccaacgtgga aaacaatgag ggacggagaa
gcaagagggg agccaggcgc 240ctgaaacgac ggagaaggca cagaatccag
agggtgaaga aactgctgtt cgattacaac 300ctgctgaccg accattctga
gctgagtgga attaatcctt atgaagccag ggtgaaaggc 360ctgagtcaga
agctgtcaga ggaagagttt tccgcagctc tgctgcacct ggctaagcgc
420cgaggagtgc ataacgtcaa tgaggtggaa gaggacaccg gcaacgagct
gtctacaaag 480gaacagatct cacgcaatag caaagctctg gaagagaagt
atgtcgcaga gctgcagctg 540gaacggctga agaaagatgg cgaggtgaga
gggtcaatta ataggttcaa gacaagcgac 600tacgtcaaag aagccaagca
gctgctgaaa gtgcagaagg cttaccacca gctggatcag 660agcttcatcg
atacttatat cgacctgctg gagactcgga gaacctacta tgagggacca
720ggagaaggga gccccttcgg atggaaagac atcaaggaat ggtacgagat
gctgatggga 780cattgcacct attttccaga agagctgaga agcgtcaagt
acgcttataa cgcagatctg 840tacaacgccc tgaatgacct gaacaacctg
gtcatcacca gggatgaaaa cgagaaactg 900gaatactatg agaagttcca
gatcatcgaa aacgtgttta agcagaagaa aaagcctaca 960ctgaaacaga
ttgctaagga gatcctggtc aacgaagagg acatcaaggg ctaccgggtg
1020acaagcactg gaaaaccaga gttcaccaat ctgaaagtgt atcacgatat
taaggacatc 1080acagcacgga aagaaatcat tgagaacgcc gaactgctgg
atcagattgc taagatcctg 1140actatctacc agagctccga ggacatccag
gaagagctga ctaacctgaa cagcgagctg 1200acccaggaag agatcgaaca
gattagtaat ctgaaggggt acaccggaac acacaacctg 1260tccctgaaag
ctatcaatct gattctggat gagctgtggc atacaaacga caatcagatt
1320gcaatcttta accggctgaa gctggtccca aaaaaggtgg acctgagtca
gcagaaagag 1380atcccaacca cactggtgga cgatttcatt ctgtcacccg
tggtcaagcg gagcttcatc 1440cagagcatca aagtgatcaa cgccatcatc
aagaagtacg gcctgcccaa tgatatcatt 1500atcgagctgg ctagggagaa
gaacagcaag gacgcacaga
agatgatcaa tgagatgcag 1560aaacgaaacc ggcagaccaa tgaacgcatt
gaagagatta tccgaactac cgggaaagag 1620aacgcaaagt acctgattga
aaaaatcaag ctgcacgata tgcaggaggg aaagtgtctg 1680tattctctgg
aggccatccc cctggaggac ctgctgaaca atccattcaa ctacgaggtc
1740gatcatatta tccccagaag cgtgtccttc gacaattcct ttaacaacaa
ggtgctggtc 1800aagcaggaag agaactctaa aaagggcaat aggactcctt
tccagtacct gtctagttca 1860gattccaaga tctcttacga aacctttaaa
aagcacattc tgaatctggc caaaggaaag 1920ggccgcatca gcaagaccaa
aaaggagtac ctgctggaag agcgggacat caacagattc 1980tccgtccaga
aggattttat taaccggaat ctggtggaca caagatacgc tactcgcggc
2040ctgatgaatc tgctgcgatc ctatttccgg gtgaacaatc tggatgtgaa
agtcaagtcc 2100atcaacggcg ggttcacatc ttttctgagg cgcaaatgga
agtttaaaaa ggagcgcaac 2160aaagggtaca agcaccatgc cgaagatgct
ctgattatcg caaatgccga cttcatcttt 2220aaggagtgga aaaagctgga
caaagccaag aaagtgatgg agaaccagat gttcgaagag 2280aagcaggccg
aatctatgcc cgaaatcgag acagaacagg agtacaagga gattttcatc
2340actcctcacc agatcaagca tatcaaggat ttcaaggact acaagtactc
tcaccgggtg 2400gataaaaagc ccaacagaga gctgatcaat gacaccctgt
atagtacaag aaaagacgat 2460aaggggaata ccctgattgt gaacaatctg
aacggactgt acgacaaaga taatgacaag 2520ctgaaaaagc tgatcaacaa
aagtcccgag aagctgctga tgtaccacca tgatcctcag 2580acatatcaga
aactgaagct gattatggag cagtacggcg acgagaagaa cccactgtat
2640aagtactatg aagagactgg gaactacctg accaagtata gcaaaaagga
taatggcccc 2700gtgatcaaga agatcaagta ctatgggaac aagctgaatg
cccatctgga catcacagac 2760gattacccta acagtcgcaa caaggtggtc
aagctgtcac tgaagccata cagattcgat 2820gtctatctgg acaacggcgt
gtataaattt gtgactgtca agaatctgga tgtcatcaaa 2880aaggagaact
actatgaagt gaatagcaag tgctacgaag aggctaaaaa gctgaaaaag
2940attagcaacc aggcagagtt catcgcctcc ttttacaaca acgacctgat
taagatcaat 3000ggcgaactgt atagggtcat cggggtgaac aatgatctgc
tgaaccgcat tgaagtgaat 3060atgattgaca tcacttaccg agagtatctg
gaaaacatga atgataagcg cccccctcga 3120attatcaaaa caattgcctc
taagactcag agtatcaaaa agtactcaac cgacattctg 3180ggaaacctgt
atgaggtgaa gagcaaaaag caccctcaga ttatcaaaaa gggctaagaa 3240ttc
3243188114RNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 188nnnnnnnnnn nnnnnnnnnn guuuuagcac
uguacaagaa auugucgugc uaaaauaagg 60cgcuguuaau gcagcugccg cauccgccag
agcauuuaug cucuggcuuu uuuu 1141891269PRTMycoplasma gallisepticum
189Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp
1 5 10 15 Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu
Thr Asn 20 25 30 Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gln
Ala Lys Thr Ala 35 40 45 Glu Asp Arg Arg Ser Phe Arg Gly Val Arg
Arg Leu Ile Arg Arg Arg 50 55 60 Lys Tyr Lys Leu Lys Arg Phe Val
Asn Leu Ile Trp Lys Tyr Asn Ser 65 70 75 80 Tyr Phe Gly Phe Lys Asn
Lys Glu Asp Ile Leu Asn Asn Tyr Gln Glu 85 90 95 Gln Gln Lys Leu
His Asn Thr Val Leu Asn Leu Lys Ser Glu Ala Leu 100 105 110 Asn Ala
Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 115 120 125
Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 130
135 140 Tyr Pro Thr Lys Glu Leu Ala Lys Tyr Phe Asp Lys Tyr Gly Tyr
Tyr 145 150 155 160 Lys Gly Ile Ile Asp Ser Lys Glu Asp Asn Asp Asn
Lys Leu Glu Glu 165 170 175 Glu Leu Thr Lys Tyr Lys Phe Ser Asn Lys
His Trp Leu Glu Glu Val 180 185 190 Lys Lys Val Leu Ser Asn Gln Thr
Gly Leu Pro Glu Lys Phe Lys Glu 195 200 205 Glu Tyr Glu Ser Leu Phe
Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 210 215 220 Gly Ser Ile Asn
Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 225 230 235 240 Lys
Glu Gly Lys Val Val Gln Lys Tyr Asn Asn Ile Trp Asp Lys Thr 245 250
255 Ile Gly Lys Cys Asn Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn
260 265 270 Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser
Thr Ile 275 280 285 Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile
Asn Gln Glu Phe 290 295 300 Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp
Leu Leu Ile Lys Thr Asn 305 310 315 320 Gly Glu Lys Pro Ile Asp Ala
Arg Gln Phe Lys Lys Leu Arg Glu Glu 325 330 335 Thr Ile Ala Glu Ser
Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Asn 340 345 350 Glu Glu Lys
Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 355 360 365 Lys
Leu Asn Thr Asn Gly Lys Ile Gln Tyr Asn Asp Leu Ser Ser Leu 370 375
380 Ala Lys Phe Val His Lys Leu Lys Gln His Leu Lys Leu Asp Phe Leu
385 390 395 400 Leu Glu Asp Gln Tyr Ala Thr Leu Asp Lys Ile Asn Phe
Leu Gln Ser 405 410 415 Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr
Ser Asn Arg Val Asp 420 425 430 Ser Ala Asn Leu Lys Glu Phe Ser Asp
Ser Asn Lys Leu Phe Glu Arg 435 440 445 Ile Leu Gln Lys Gln Lys Asp
Gly Leu Phe Lys Leu Phe Glu Gln Thr 450 455 460 Asp Lys Asp Asp Glu
Lys Ile Leu Ala Gln Thr His Ser Leu Ser Thr 465 470 475 480 Lys Ala
Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 485 490 495
Glu Asp Asn Gln Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 500
505 510 Lys Asn Phe Asp Gln Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn
Asn 515 520 525 Leu Ser Leu Lys Gln Asn Lys Arg Tyr Leu Asp Asp Arg
Phe Ile Asn 530 535 540 Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile
Leu Arg Glu Ala Thr 545 550 555 560 Lys Val Phe Asn Ala Ile Leu Lys
Gln Phe Ser Glu Glu Tyr Asp Val 565 570 575 Thr Lys Val Val Ile Glu
Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 580 585 590 Leu Glu Asn Thr
Lys Asn Tyr Lys Lys Leu Ile Lys Lys Asn Gly Asp 595 600 605 Lys Ile
Ser Glu Gly Leu Lys Ala Leu Gly Ile Ser Glu Asp Glu Ile 610 615 620
Lys Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Phe Leu Leu Trp 625
630 635 640 Leu Gln Gln Asp His Ile Asp Pro Tyr Ser Leu Lys Glu Ile
Ala Phe 645 650 655 Asp Asp Ile Phe Thr Lys Thr Glu Lys Phe Glu Ile
Asp His Ile Ile 660 665 670 Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser
Ser Asn Lys Leu Leu Val 675 680 685 Leu Ala Glu Ser Asn Gln Ala Lys
Ser Asn Gln Thr Pro Tyr Glu Phe 690 695 700 Ile Ser Ser Gly Asn Ala
Gly Ile Lys Trp Glu Asp Tyr Glu Ala Tyr 705 710 715 720 Cys Arg Lys
Phe Lys Asp Gly Asp Ser Ser Leu Leu Asp Ser Thr Gln 725 730 735 Arg
Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 740 745
750 Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala
755 760 765 Thr Ile Val Phe Arg Asp Ala Leu Glu Asp Tyr Ala Asn Asn
His Leu 770 775 780 Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile
Asn Gly Ser Val 785 790 795 800 Thr Ser Phe Leu Arg Lys Asn Phe Asp
Asp Ser Ser Tyr Ala Lys Lys 805 810 815 Asp Arg Asp Lys Asn Ile His
His Ala Val Asp Ala Ser Ile Ile Ser 820 825 830 Ile Phe Ser Asn Glu
Thr Lys Thr Leu Phe Asn Gln Leu Thr Gln Phe 835 840 845 Ala Asp Tyr
Lys Leu Phe Lys Asn Thr Asp Gly Ser Trp Lys Lys Ile 850 855 860 Asp
Pro Lys Thr Gly Val Val Thr Glu Val Thr Asp Glu Asn Trp Lys 865 870
875 880 Gln Ile Arg Val Arg Asn Gln Val Ser Glu Ile Ala Lys Val Ile
Glu 885 890 895 Lys Tyr Ile Gln Asp Ser Asn Ile Glu Arg Lys Ala Arg
Tyr Ser Arg 900 905 910 Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe
Asn Asp Thr Val Tyr 915 920 925 Ser Ala Lys Lys Val Gly Tyr Glu Asp
Gln Ile Lys Arg Lys Asn Leu 930 935 940 Lys Thr Leu Asp Ile His Glu
Ser Ala Lys Glu Asn Lys Asn Ser Lys 945 950 955 960 Val Lys Arg Gln
Phe Val Tyr Arg Lys Leu Val Asn Val Ser Leu Leu 965 970 975 Asn Asn
Asp Lys Leu Ala Asp Leu Phe Ala Glu Lys Glu Asp Ile Leu 980 985 990
Met Tyr Arg Ala Asn Pro Trp Val Ile Asn Leu Ala Glu Gln Ile Phe 995
1000 1005 Asn Glu Tyr Thr Glu Asn Lys Lys Ile Lys Ser Gln Asn Val
Phe 1010 1015 1020 Glu Lys Tyr Met Leu Asp Leu Thr Lys Glu Phe Pro
Glu Lys Phe 1025 1030 1035 Ser Glu Phe Leu Val Lys Ser Met Leu Arg
Asn Lys Thr Ala Ile 1040 1045 1050 Ile Tyr Asp Asp Lys Lys Asn Ile
Val His Arg Ile Lys Arg Leu 1055 1060 1065 Lys Met Leu Ser Ser Glu
Leu Lys Glu Asn Lys Leu Ser Asn Val 1070 1075 1080 Ile Ile Arg Ser
Lys Asn Gln Ser Gly Thr Lys Leu Ser Tyr Gln 1085 1090 1095 Asp Thr
Ile Asn Ser Leu Ala Leu Met Ile Met Arg Ser Ile Asp 1100 1105 1110
Pro Thr Ala Lys Lys Gln Tyr Ile Arg Val Pro Leu Asn Thr Leu 1115
1120 1125 Asn Leu His Leu Gly Asp His Asp Phe Asp Leu His Asn Met
Asp 1130 1135 1140 Ala Tyr Leu Lys Lys Pro Lys Phe Val Lys Tyr Leu
Lys Ala Asn 1145 1150 1155 Glu Ile Gly Asp Glu Tyr Lys Pro Trp Arg
Val Leu Thr Ser Gly 1160 1165 1170 Thr Leu Leu Ile His Lys Lys Asp
Lys Lys Leu Met Tyr Ile Ser 1175 1180 1185 Ser Phe Gln Asn Leu Asn
Asp Val Ile Glu Ile Lys Asn Leu Ile 1190 1195 1200 Glu Thr Glu Tyr
Lys Glu Asn Asp Asp Ser Asp Ser Lys Lys Lys 1205 1210 1215 Lys Lys
Ala Asn Arg Phe Leu Met Thr Leu Ser Thr Ile Leu Asn 1220 1225 1230
Asp Tyr Ile Leu Leu Asp Ala Lys Asp Asn Phe Asp Ile Leu Gly 1235
1240 1245 Leu Ser Lys Asn Arg Ile Asp Glu Ile Leu Asn Ser Lys Leu
Gly 1250 1255 1260 Leu Asp Lys Ile Val Lys 1265
1903891DNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 190accggtgcca ccatgtaccc atacgatgtt
ccagattacg cttcgccgaa gaaaaagcgc 60aaggtcgaag cgtccatgaa caatagcatc
aaatctaaac ctgaagtgac catcgggctg 120gacctgggag tgggaagcgt
ggggtgggca atcgtggata acgaaacaaa catcattcac 180catctgggct
ccaggctgtt ttctcaggcc aagactgctg aggatcggag atctttccgc
240ggggtgaggc gcctgatccg acggagaaaa tacaagctga aacgattcgt
caatctgatt 300tggaagtaca acagctattt cggcttcaag aacaaagagg
acatcctgaa caattatcag 360gagcagcaga agctgcacaa taccgtgctg
aacctgaaat cagaggcact gaatgccaag 420atcgatccta aagcactgag
ctggattctg cacgactacc tgaagaacag aggccatttt 480tatgaggaca
atagggattt caacgtgtac ccaacaaagg agctggccaa gtacttcgat
540aagtacgggt actacaaggg aatcattgac agcaaggagg acaatgataa
caaactggag 600gaagagctga caaagtacaa attctccaat aagcactggc
tggaagaggt gaagaaagtc 660ctgtctaacc agactggcct gccagaaaag
tttaaagaag agtatgagtc actgttcagc 720tacgtgagaa attattcaga
gggcccaggg agcatcaact ctgtcagtcc ctacgggatc 780taccatctgg
acgaaaaaga gggaaaggtg gtccagaagt acaacaacat ctgggataag
840acaatcggaa agtgcaacat cttccctgac gagtatagag ctcccaagaa
cagtcctatc 900gcaatgattt tcaatgaaat caacgagctg tccacaatca
ggtcatacag catctacctg 960actggctggt tcattaatca ggagttcaag
aaagcctacc tgaacaagct gctggatctg 1020ctgatcaaaa ccaacggaga
gaagccaatt gacgcaaggc agttcaagaa actgcgcgaa 1080gagacaatcg
ccgaaagcat tggcaaagag acactgaagg atgtggagaa tgaagagaaa
1140ctggaaaagg aggaccacaa gtggaaactg aagggactga agctgaatac
caacggcaaa 1200atccagtaca acgatctgag ctccctggct aagtttgtgc
acaaactgaa gcagcatctg 1260aaactggatt tcctgctgga ggaccagtat
gcaacactgg acaagatcaa tttcctgcag 1320tccctgtttg tgtacctggg
caagcacctg agatattcca atagggtcga ttctgccaac 1380ctgaaggaat
tttccgactc taacaaactg ttcgagcgca tcctgcagaa acagaaggat
1440gggctgttca agctgtttga acagactgac aaagacgatg agaagatcct
ggcccagaca 1500catagtctgt caactaaggc catgctgctg gctattaccc
ggatgacaaa tctggacaac 1560gatgaggaca accagaaaaa caatgacaag
ggctggaatt ttgaggccat caaaaacttc 1620gatcagaagt ttatcgacat
caccaagaaa aacaacaacc tgagcctgaa acagaataag 1680cgctacctgg
acgatcgatt catcaacgat gctattctgt cccctggggt gaagcgaatc
1740ctgcgggagg caaccaaggt ctttaatgcc attctgaaac agttctctga
agagtacgac 1800gtgacaaagg tggtcatcga actggctcgc gagctgagcg
aagagaagga actggagaac 1860acaaagaact acaagaaact gatcaagaaa
aacggcgaca agattagtga gggcctgaaa 1920gcactgggga tctcagaaga
tgagatcaaa gacattctga agagtcccac taaatcatac 1980aagtttctgc
tgtggctgca gcaggaccac atcgatcctt atagcctgaa ggagatcgcc
2040ttcgacgata tttttaccaa aacagaaaag ttcgagatcg accatatcat
tccctacagc 2100atttccttcg acgattctag ttcaaacaag ctgctggtgc
tggctgaaag taatcaggca 2160aagtcaaacc agactcctta tgagttcatc
agctccggaa acgcaggcat taagtgggaa 2220gattacgagg cctattgccg
caagttcaag gatggggact ctagtctgct ggacagcacc 2280cagcggtcca
agaaattcgc caaaatgatg aaaaccgata cctcaagcaa gtacgacatc
2340ggatttctgg ctcgaaatct gaacgatact cggtacgcaa ccattgtgtt
ccgggacgcc 2400ctggaggact atgctaataa ccacctggtc gaggacaaac
ccatgtttaa ggtggtctgt 2460atcaatgggt ccgtgacctc tttcctgcgg
aagaactttg acgattcctc ttacgccaag 2520aaagatagag acaagaatat
ccaccatgct gtggatgcaa gtatcatctc aattttcagc 2580aacgagacaa
agactctgtt caaccagctg actcagtttg ctgactataa actgttcaag
2640aacaccgatg gcagctggaa gaaaatcgac cctaagacag gggtggtcac
tgaagtgacc 2700gacgagaatt ggaagcagat tagggtgcgc aaccaggtga
gcgaaatcgc caaagtcatt 2760gagaagtaca tccaggatag caacatcgaa
agaaaggcta ggtattcccg caaaatcgag 2820aataagacta acatttccct
gtttaatgac accgtgtact ctgccaagaa agtcggctat 2880gaggatcaga
tcaaaagaaa gaacctgaaa accctggaca ttcacgaatc tgctaaagag
2940aataagaaca gtaaagtgaa gcggcagttt gtctacagaa agctggtgaa
tgtcagcctg 3000ctgaataacg ataagctggc agacctgttc gccgaaaaag
aggatatcct gatgtatagg 3060gccaatccat gggtcatcaa cctggctgag
cagattttca atgaatacac tgagaacaag 3120aaaatcaagt cccagaacgt
gtttgaaaaa tatatgctgg acctgaccaa agagttcccc 3180gagaagttca
gcgagtttct ggtgaagtcc atgctgagaa acaagaccgc catcatctac
3240gacgataaga aaaacattgt ccatcgaatc aaacggctga agatgctgag
ttcagaactg 3300aaagagaata agctgtctaa cgtgatcatt aggtctaaga
atcagagtgg gaccaaactg 3360tcataccagg atacaatcaa cagcctggcc
ctgatgatta tgcgcagcat cgaccctact 3420gctaagaaac agtatattcg
agtgccactg aataccctga acctgcacct gggagatcat 3480gactttgatc
tgcacaatat ggatgcttac ctgaagaaac caaaattcgt gaagtatctg
3540aaagcaaacg aaatcggcga cgagtacaag ccctggaggg tcctgacatc
tggcactctg 3600ctgatccata agaaggataa gaaactgatg tacatcagct
ccttccagaa tctgaacgac 3660gtgatcgaaa ttaagaatct gatcgaaacc
gagtataaag agaacgacga ttctgatagt 3720aagaaaaaga aaaaggcaaa
ccgctttctg atgaccctga gcacaatcct gaatgactac 3780attctgctgg
acgccaagga taacttcgac atcctggggc tgtctaaaaa tcggatcgat
3840gagattctga acagtaagct gggactggac aagattgtga aataagaatt c
3891191137RNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 191nnnnnnnnnn nnnnnnnnnn guuuuagucu
cugaaaagag acuaaaauaa gugguuuuug 60gucauccacg caggguuaca aucccuuuaa
aaccauuaaa auucaaauaa acuagguugu 120aucaacuuag uuuuuuu
1371921003PRTCampylobacter lari 192Met Arg Ile Leu Gly Phe Asp Ile
Gly Ile Asn Ser Ile Gly Trp Ala 1 5 10 15 Phe Val Glu Asn Asp Glu
Leu Lys Asp Cys Gly Val Arg Ile Phe Thr 20 25 30 Lys Ala Glu Asn
Pro Lys Asn Lys Glu Ser Leu Ala Leu Pro Arg Arg 35 40 45 Asn Ala
Arg Ser Ser Arg Arg Arg Leu Lys Arg Arg Lys Ala
Arg Leu 50 55 60 Ile Ala Ile Lys Arg Ile Leu Ala Lys Glu Leu Lys
Leu Asn Tyr Lys 65 70 75 80 Asp Tyr Val Ala Ala Asp Gly Glu Leu Pro
Lys Ala Tyr Glu Gly Ser 85 90 95 Leu Ala Ser Val Tyr Glu Leu Arg
Tyr Lys Ala Leu Thr Gln Asn Leu 100 105 110 Glu Thr Lys Asp Leu Ala
Arg Val Ile Leu His Ile Ala Lys His Arg 115 120 125 Gly Tyr Met Asn
Lys Asn Glu Lys Lys Ser Asn Asp Ala Lys Lys Gly 130 135 140 Lys Ile
Leu Ser Ala Leu Lys Asn Asn Ala Leu Lys Leu Glu Asn Tyr 145 150 155
160 Gln Ser Val Gly Glu Tyr Phe Tyr Lys Glu Phe Phe Gln Lys Tyr Lys
165 170 175 Lys Asn Thr Lys Asn Phe Ile Lys Ile Arg Asn Thr Lys Asp
Asn Tyr 180 185 190 Asn Asn Cys Val Leu Ser Ser Asp Leu Glu Lys Glu
Leu Lys Leu Ile 195 200 205 Leu Glu Lys Gln Lys Glu Phe Gly Tyr Asn
Tyr Ser Glu Asp Phe Ile 210 215 220 Asn Glu Ile Leu Lys Val Ala Phe
Phe Gln Arg Pro Leu Lys Asp Phe 225 230 235 240 Ser His Leu Val Gly
Ala Cys Thr Phe Phe Glu Glu Glu Lys Arg Ala 245 250 255 Cys Lys Asn
Ser Tyr Ser Ala Trp Glu Phe Val Ala Leu Thr Lys Ile 260 265 270 Ile
Asn Glu Ile Lys Ser Leu Glu Lys Ile Ser Gly Glu Ile Val Pro 275 280
285 Thr Gln Thr Ile Asn Glu Val Leu Asn Leu Ile Leu Asp Lys Gly Ser
290 295 300 Ile Thr Tyr Lys Lys Phe Arg Ser Cys Ile Asn Leu His Glu
Ser Ile 305 310 315 320 Ser Phe Lys Ser Leu Lys Tyr Asp Lys Glu Asn
Ala Glu Asn Ala Lys 325 330 335 Leu Ile Asp Phe Arg Lys Leu Val Glu
Phe Lys Lys Ala Leu Gly Val 340 345 350 His Ser Leu Ser Arg Gln Glu
Leu Asp Gln Ile Ser Thr His Ile Thr 355 360 365 Leu Ile Lys Asp Asn
Val Lys Leu Lys Thr Val Leu Glu Lys Tyr Asn 370 375 380 Leu Ser Asn
Glu Gln Ile Asn Asn Leu Leu Glu Ile Glu Phe Asn Asp 385 390 395 400
Tyr Ile Asn Leu Ser Phe Lys Ala Leu Gly Met Ile Leu Pro Leu Met 405
410 415 Arg Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Ile Ala Asn Leu
Lys 420 425 430 Pro Lys Thr Val Asp Glu Lys Lys Asp Phe Leu Pro Ala
Phe Cys Asp 435 440 445 Ser Ile Phe Ala His Glu Leu Ser Asn Pro Val
Val Asn Arg Ala Ile 450 455 460 Ser Glu Tyr Arg Lys Val Leu Asn Ala
Leu Leu Lys Lys Tyr Gly Lys 465 470 475 480 Val His Lys Ile His Leu
Glu Leu Ala Arg Asp Val Gly Leu Ser Lys 485 490 495 Lys Ala Arg Glu
Lys Ile Glu Lys Glu Gln Lys Glu Asn Gln Ala Val 500 505 510 Asn Ala
Trp Ala Leu Lys Glu Cys Glu Asn Ile Gly Leu Lys Ala Ser 515 520 525
Ala Lys Asn Ile Leu Lys Leu Lys Leu Trp Lys Glu Gln Lys Glu Ile 530
535 540 Cys Ile Tyr Ser Gly Asn Lys Ile Ser Ile Glu His Leu Lys Asp
Glu 545 550 555 560 Lys Ala Leu Glu Val Asp His Ile Tyr Pro Tyr Ser
Arg Ser Phe Asp 565 570 575 Asp Ser Phe Ile Asn Lys Val Leu Val Phe
Thr Lys Glu Asn Gln Glu 580 585 590 Lys Leu Asn Lys Thr Pro Phe Glu
Ala Phe Gly Lys Asn Ile Glu Lys 595 600 605 Trp Ser Lys Ile Gln Thr
Leu Ala Gln Asn Leu Pro Tyr Lys Lys Lys 610 615 620 Asn Lys Ile Leu
Asp Glu Asn Phe Lys Asp Lys Gln Gln Glu Asp Phe 625 630 635 640 Ile
Ser Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Thr Leu Ile Ala 645 650
655 Lys Tyr Thr Lys Glu Tyr Leu Asn Phe Leu Leu Leu Ser Glu Asn Glu
660 665 670 Asn Ala Asn Leu Lys Ser Gly Glu Lys Gly Ser Lys Ile His
Val Gln 675 680 685 Thr Ile Ser Gly Met Leu Thr Ser Val Leu Arg His
Thr Trp Gly Phe 690 695 700 Asp Lys Lys Asp Arg Asn Asn His Leu His
His Ala Leu Asp Ala Ile 705 710 715 720 Ile Val Ala Tyr Ser Thr Asn
Ser Ile Ile Lys Ala Phe Ser Asp Phe 725 730 735 Arg Lys Asn Gln Glu
Leu Leu Lys Ala Arg Phe Tyr Ala Lys Glu Leu 740 745 750 Thr Ser Asp
Asn Tyr Lys His Gln Val Lys Phe Phe Glu Pro Phe Lys 755 760 765 Ser
Phe Arg Glu Lys Ile Leu Ser Lys Ile Asp Glu Ile Phe Val Ser 770 775
780 Lys Pro Pro Arg Lys Arg Ala Arg Arg Ala Leu His Lys Asp Thr Phe
785 790 795 800 His Ser Glu Asn Lys Ile Ile Asp Lys Cys Ser Tyr Asn
Ser Lys Glu 805 810 815 Gly Leu Gln Ile Ala Leu Ser Cys Gly Arg Val
Arg Lys Ile Gly Thr 820 825 830 Lys Tyr Val Glu Asn Asp Thr Ile Val
Arg Val Asp Ile Phe Lys Lys 835 840 845 Gln Asn Lys Phe Tyr Ala Ile
Pro Ile Tyr Ala Met Asp Phe Ala Leu 850 855 860 Gly Ile Leu Pro Asn
Lys Ile Val Ile Thr Gly Lys Asp Lys Asn Asn 865 870 875 880 Asn Pro
Lys Gln Trp Gln Thr Ile Asp Glu Ser Tyr Glu Phe Cys Phe 885 890 895
Ser Leu Tyr Lys Asn Asp Leu Ile Leu Leu Gln Lys Lys Asn Met Gln 900
905 910 Glu Pro Glu Phe Ala Tyr Tyr Asn Asp Phe Ser Ile Ser Thr Ser
Ser 915 920 925 Ile Cys Val Glu Lys His Asp Asn Lys Phe Glu Asn Leu
Thr Ser Asn 930 935 940 Gln Lys Leu Leu Phe Ser Asn Ala Lys Glu Gly
Ser Val Lys Val Glu 945 950 955 960 Ser Leu Gly Ile Gln Asn Leu Lys
Val Phe Glu Lys Tyr Ile Ile Thr 965 970 975 Pro Leu Gly Asp Lys Ile
Lys Ala Asp Phe Gln Pro Arg Glu Asn Ile 980 985 990 Ser Leu Lys Thr
Ser Lys Lys Tyr Gly Leu Arg 995 1000 1933093DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
193accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtccatgag gattctgggg tttgacattg gcattaacag
catcgggtgg 120gcttttgtgg agaacgacga actgaaggac tgcggagtgc
ggatcttcac aaaggccgag 180aacccaaaaa ataaggaaag cctggcactg
ccccggagaa atgcacgcag ctccaggcgc 240cgactgaaac ggagaaaggc
ccggctgatc gctattaaga gaatcctggc caaagagctg 300aagctgaact
acaaggacta tgtcgcagct gatggagagc tgccaaaggc ctacgaagga
360tccctggcat ctgtgtacga gctgcggtat aaggccctga cacagaacct
ggaaactaaa 420gatctggcca gagtgatcct gcacattgct aagcataggg
ggtacatgaa caagaacgag 480aagaaatcaa acgacgctaa gaaaggaaag
atcctgagcg ctctgaaaaa caatgcactg 540aagctggaga actaccagag
cgtgggcgaa tacttctaca aggagttctt tcagaaatac 600aagaaaaaca
caaagaactt catcaagatc cgcaacacta aggataatta caacaattgc
660gtgctgtcta gtgacctgga aaaagagctg aagctgatcc tggaaaaaca
gaaggagttc 720ggctacaact actctgaaga tttcatcaac gagattctga
aggtcgcctt ctttcagcgg 780cccctgaagg acttcagtca cctggtgggg
gcctgcactt tctttgagga agagaaaagg 840gcctgtaaga acagctactc
tgcctgggag tttgtggctc tgaccaagat cattaacgag 900atcaagagcc
tggagaagat cagcggcgaa attgtgccaa cccagacaat caacgaggtc
960ctgaatctga tcctggacaa ggggtctatc acctacaaga aattcagaag
ttgtatcaat 1020ctgcatgaga gtatcagctt caagagcctg aagtatgata
aagaaaacgc cgagaatgct 1080aaactgatcg acttccgcaa gctggtggag
tttaagaaag ccctgggagt ccacagcctg 1140tcccggcagg aactggatca
gatctccact catatcaccc tgattaagga caacgtgaag 1200ctgaaaaccg
tcctggagaa atacaacctg agtaatgaac agatcaacaa tctgctggaa
1260attgagttca acgattatat caacctgagc ttcaaggccc tgggaatgat
tctgccactg 1320atgcgcgagg gcaaacgata cgacgaggcc tgcgagatcg
ccaatctgaa acctaagacc 1380gtggacgaga agaaagattt cctgccagca
ttttgtgatt ccattttcgc ccacgagctg 1440tctaaccccg tggtcaatag
ggctatcagc gaataccgca aggtgctgaa cgcactgctg 1500aagaaatatg
gaaaggtcca caaaattcat ctggagctgg ctcgcgacgt gggcctgtcc
1560aagaaagcac gagagaagat cgaaaaagag cagaaggaaa accaggccgt
gaatgcatgg 1620gccctgaagg aatgcgagaa tattggcctg aaggccagcg
caaagaacat cctgaaactg 1680aagctgtgga aagaacagaa ggagatctgt
atctactccg gaaataagat ctctattgag 1740cacctgaaag atgaaaaggc
cctggaggtg gaccatatct acccctattc taggagtttc 1800gacgattctt
ttatcaacaa agtgctggtg ttcaccaagg aaaatcagga gaaactgaac
1860aagacacctt tcgaggcctt tggcaagaat attgaaaaat ggagcaagat
ccagaccctg 1920gctcagaacc tgccatacaa gaaaaagaat aagattctgg
acgagaactt caaagataag 1980cagcaggagg actttatctc tcgaaatctg
aacgacaccc ggtatatcgc tacactgatt 2040gcaaaataca caaaggagta
tctgaacttc ctgctgctga gcgaaaatga gaacgccaat 2100ctgaagagtg
gcgaaaaagg gtcaaagatc cacgtgcaga ctattagcgg gatgctgacc
2160tccgtcctga ggcacacatg ggggtttgac aaaaaggatc gcaacaatca
tctgcaccat 2220gcactggatg ccatcattgt ggcctacagt acaaattcaa
tcattaaggc tttcagcgat 2280ttccggaaaa accaggagct gctgaaggcc
agattctacg ctaaagaact gacttccgat 2340aactataaac atcaggtcaa
gttctttgag cctttcaaga gttttagaga aaaaatcctg 2400tcaaagatcg
acgagatttt cgtgtccaaa ccacctcgaa agcgagctag gcgcgcactg
2460cacaaggata cctttcattc tgagaacaag atcattgaca agtgcagcta
caactccaag 2520gaaggcctgc agattgccct gagctgtgga agagtgagga
aaatcggcac taagtatgtc 2580gagaatgata ccatcgtgag ggtcgacatt
ttcaaaaagc agaacaagtt ttacgctatc 2640ccaatctacg caatggattt
tgccctgggg atcctgccca ataagatcgt gattactgga 2700aaagataaga
acaataaccc caaacagtgg cagaccattg acgaatcata cgagttctgc
2760tttagcctgt ataagaatga cctgatcctg ctgcagaaaa agaacatgca
ggaacctgag 2820ttcgcctact ataacgattt ttcaatcagc acatcaagca
tttgtgtgga gaaacacgac 2880aacaagttcg aaaatctgac tagcaaccag
aagctgctgt tttccaatgc aaaagagggc 2940tctgtgaagg tcgaaagtct
ggggatccag aacctgaaag tgttcgagaa gtacatcatt 3000acccccctgg
gagataaaat taaggctgac tttcagcctc gagaaaacat cagcctgaaa
3060accagtaaaa agtatggcct gaggtaagaa ttc 3093194103RNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
194nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau
aaggcuaguc 60cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu uuu
1031951368PRTStreptococcus pyogenes 195Met Asp Lys Lys Tyr Ser Ile
Gly Leu Asp Ile Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala Val Ile
Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu
Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly
Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55
60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys
65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp
Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu
Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile
Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr
His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp
Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys
Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp
Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 180 185
190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala
195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu
Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly
Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr
Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys
Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn
Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275 280 285 Leu Phe Leu
Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile
Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310
315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu
Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu
Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile
Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys
Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val
Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gln Arg Thr
Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 405 410 415 Gly Glu
Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 420 425 430
Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435
440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala
Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn
Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gln Ser
Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn
Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe
Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu
Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys
Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555
560 Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp
565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser
Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys
Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp
Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile
Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp
Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp
Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys
Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680
685 Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe
690 695 700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp
Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro
Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys Val Val Asp
Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile
Val Ile Glu Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr Gln Lys Gly
Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly
Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785 790 795 800
Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805
810 815 Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn
Arg 820 825 830
Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 835
840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn
Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys
Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys
Leu Ile Thr Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu
Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys
Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 915 920 925 Lys His Val Ala
Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn
Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945 950 955
960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg
965 970 975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn
Ala Val 980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu
Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp
Val Arg Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gln Glu Ile Gly
Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met
Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu
Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr
Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075
1080 Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr
1085 1090 1095 Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu
Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys
Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro
Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu
Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu
Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Phe Glu Lys
Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180 1185 Glu
Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 1190 1195
1200 Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly
1205 1210 1215 Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys
Tyr Val 1220 1225 1230 Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys
Leu Lys Gly Ser 1235 1240 1245 Pro Glu Asp Asn Glu Gln Lys Gln Leu
Phe Val Glu Gln His Lys 1250 1255 1260 His Tyr Leu Asp Glu Ile Ile
Glu Gln Ile Ser Glu Phe Ser Lys 1265 1270 1275 Arg Val Ile Leu Ala
Asp Ala Asn Leu Asp Lys Val Leu Ser Ala 1280 1285 1290 Tyr Asn Lys
His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 Ile
Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315
1320 Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser
1325 1330 1335 Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser
Ile Thr 1340 1345 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln
Leu Gly Gly Asp 1355 1360 1365 1964218DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
196accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtccgacaa gaagtacagc atcggcctgg acatcggcac
caactctgtg 120ggctgggccg tgatcaccga cgagtacaag gtgcccagca
agaaattcaa ggtgctgggc 180aacaccgacc ggcacagcat caagaagaac
ctgatcggag ccctgctgtt cgacagcggc 240gaaacagccg aggccacccg
gctgaagaga accgccagaa gaagatacac cagacggaag 300aaccggatct
gctatctgca agagatcttc agcaacgaga tggccaaggt ggacgacagc
360ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca
cgagcggcac 420cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg
agaagtaccc caccatctac 480cacctgagaa agaaactggt ggacagcacc
gacaaggccg acctgcggct gatctatctg 540gccctggccc acatgatcaa
gttccggggc cacttcctga tcgagggcga cctgaacccc 600gacaacagcg
acgtggacaa gctgttcatc cagctggtgc agacctacaa ccagctgttc
660gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc
tgccagactg 720agcaagagca gacggctgga aaatctgatc gcccagctgc
ccggcgagaa gaagaatggc 780ctgttcggca acctgattgc cctgagcctg
ggcctgaccc ccaacttcaa gagcaacttc 840gacctggccg aggatgccaa
actgcagctg agcaaggaca cctacgacga cgacctggac 900aacctgctgg
cccagatcgg cgaccagtac gccgacctgt ttctggccgc caagaacctg
960tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac
caaggccccc 1020ctgagcgcct ctatgatcaa gagatacgac gagcaccacc
aggacctgac cctgctgaaa 1080gctctcgtgc ggcagcagct gcctgagaag
tacaaagaga ttttcttcga ccagagcaag 1140aacggctacg ccggctacat
tgacggcgga gccagccagg aagagttcta caagttcatc 1200aagcccatcc
tggaaaagat ggacggcacc gaggaactgc tcgtgaagct gaacagagag
1260gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca
gatccacctg 1320ggagagctgc acgccattct gcggcggcag gaagattttt
acccattcct gaaggacaac 1380cgggaaaaga tcgagaagat cctgaccttc
cgcatcccct actacgtggg ccctctggcc 1440aggggaaaca gcagattcgc
ctggatgacc agaaagagcg aggaaaccat caccccctgg 1500aacttcgagg
aagtggtgga caagggcgct tccgcccaga gcttcatcga gcggatgacc
1560aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct
gctgtacgag 1620tacttcaccg tgtataacga gctgaccaaa gtgaaatacg
tgaccgaggg aatgagaaag 1680cccgccttcc tgagcggcga gcagaaaaag
gccatcgtgg acctgctgtt caagaccaac 1740cggaaagtga ccgtgaagca
gctgaaagag gactacttca agaaaatcga gtgcttcgac 1800tccgtggaaa
tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac ataccacgat
1860ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga
ggacattctg 1920gaagatatcg tgctgaccct gacactgttt gaggacagag
agatgatcga ggaacggctg 1980aaaacctatg cccacctgtt cgacgacaaa
gtgatgaagc agctgaagcg gcggagatac 2040accggctggg gcaggctgag
ccggaagctg atcaacggca tccgggacaa gcagtccggc 2100aagacaatcc
tggatttcct gaagtccgac ggcttcgcca acagaaactt catgcagctg
2160atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt
gtccggccag 2220ggcgatagcc tgcacgagca cattgccaat ctggccggca
gccccgccat taagaagggc 2280atcctgcaga cagtgaaggt ggtggacgag
ctcgtgaaag tgatgggccg gcacaagccc 2340gagaacatcg tgatcgaaat
ggccagagag aaccagacca cccagaaggg acagaagaac 2400agccgcgaga
gaatgaagcg gatcgaagag ggcatcaaag agctgggcag ccagatcctg
2460aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct
gtactacctg 2520cagaatgggc gggatatgta cgtggaccag gaactggaca
tcaaccggct gtccgactac 2580gatgtggacc atatcgtgcc tcagagcttt
ctgaaggacg actccatcga caacaaggtg 2640ctgaccagaa gcgacaagaa
ccggggcaag agcgacaacg tgccctccga agaggtcgtg 2700aagaagatga
agaactactg gcggcagctg ctgaacgcca agctgattac ccagagaaag
2760ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa
ggccggcttc 2820atcaagagac agctggtgga aacccggcag atcacaaagc
acgtggcaca gatcctggac 2880tcccggatga acactaagta cgacgagaat
gacaagctga tccgggaagt gaaagtgatc 2940accctgaagt ccaagctggt
gtccgatttc cggaaggatt tccagtttta caaagtgcgc 3000gagatcaaca
actaccacca cgcccacgac gcctacctga acgccgtcgt gggaaccgcc
3060ctgatcaaaa agtaccctaa gctggaaagc gagttcgtgt acggcgacta
caaggtgtac 3120gacgtgcgga agatgatcgc caagagcgag caggaaatcg
gcaaggctac cgccaagtac 3180ttcttctaca gcaacatcat gaactttttc
aagaccgaga ttaccctggc caacggcgag 3240atccggaagc ggcctctgat
cgagacaaac ggcgaaaccg gggagatcgt gtgggataag 3300ggccgggatt
ttgccaccgt gcggaaagtg ctgagcatgc cccaagtgaa tatcgtgaaa
3360aagaccgagg tgcagacagg cggcttcagc aaagagtcta tcctgcccaa
gaggaacagc 3420gataagctga tcgccagaaa gaaggactgg gaccctaaga
agtacggcgg cttcgacagc 3480cccaccgtgg cctattctgt gctggtggtg
gccaaagtgg aaaagggcaa gtccaagaaa 3540ctgaagagtg tgaaagagct
gctggggatc accatcatgg aaagaagcag cttcgagaag 3600aatcccatcg
actttctgga agccaagggc tacaaagaag tgaaaaagga cctgatcatc
3660aagctgccta agtactccct gttcgagctg gaaaacggcc ggaagagaat
gctggcctct 3720gccggcgaac tgcagaaggg aaacgaactg gccctgccct
ccaaatatgt gaacttcctg 3780tacctggcca gccactatga gaagctgaag
ggctcccccg aggataatga gcagaaacag 3840ctgtttgtgg aacagcacaa
gcactacctg gacgagatca tcgagcagat cagcgagttc 3900tccaagagag
tgatcctggc cgacgctaat ctggacaaag tgctgtccgc ctacaacaag
3960caccgggata agcccatcag agagcaggcc gagaatatca tccacctgtt
taccctgacc 4020aatctgggag cccctgccgc cttcaagtac tttgacacca
ccatcgaccg gaagaggtac 4080accagcacca aagaggtgct ggacgccacc
ctgatccacc agagcatcac cggcctgtac 4140gagacacgga tcgacctgtc
tcagctggga ggcgacagcc ccaagaagaa gagaaaggtg 4200gaggccagct aagaattc
4218197116RNAArtificial SequenceDescription of Artificial Sequence
Synthetic polynucleotide 197nnnnnnnnnn nnnnnnnnnn guuuuuguac
ucucaagauu uagaaacuug cagaagcuac 60aaagauaagg cuucaugccg aaaucaacac
ccugucauuu uauggcaggg uguuuu 1161981120PRTStreptococcus
thermophilus 198Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly
Ser Val Gly 1 5 10 15 Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile
Ile His Lys Asn Ser 20 25 30 Arg Ile Phe Pro Ala Ala Gln Ala Glu
Asn Asn Leu Val Arg Arg Thr 35 40 45 Asn Arg Gln Gly Arg Arg Leu
Ala Arg Arg Lys Lys His Arg Arg Val 50 55 60 Arg Leu Asn Arg Leu
Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 65 70 75 80 Lys Ile Ser
Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 85 90 95 Thr
Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 100 105
110 Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly
115 120 125 Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn
Ser Lys 130 135 140 Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu
Glu Arg Tyr Gln 145 150 155 160 Thr Tyr Gly Gln Leu Arg Gly Asp Phe
Thr Val Glu Lys Asp Gly Lys 165 170 175 Lys His Arg Leu Ile Asn Val
Phe Pro Thr Ser Ala Tyr Arg Ser Glu 180 185 190 Ala Leu Arg Ile Leu
Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 195 200 205 Asp Glu Phe
Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr
Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230
235 240 Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu
Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala
Lys Ala Ser 260 265 270 Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp
Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser
Lys Glu Gln Lys Asn Gln Ile 290 295 300 Ile Asn Tyr Val Lys Asn Glu
Lys Ala Met Gly Pro Ala Lys Leu Phe 305 310 315 320 Lys Tyr Ile Ala
Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 325 330 335 Tyr Arg
Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 340 345 350
Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 355
360 365 Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr
Glu 370 375 380 Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala
Asp Gly Ser 385 390 395 400 Phe Ser Gln Lys Gln Val Asp Glu Leu Val
Gln Phe Arg Lys Ala Asn 405 410 415 Ser Ser Ile Phe Gly Lys Gly Trp
His Asn Phe Ser Val Lys Leu Met 420 425 430 Met Glu Leu Ile Pro Glu
Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 435 440 445 Ile Leu Thr Arg
Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 450 455 460 Thr Lys
Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 465 470 475
480 Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala
485 490 495 Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met
Ala Arg 500 505 510 Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln
Lys Ile Gln Lys 515 520 525 Ala Asn Lys Asp Glu Lys Asp Ala Ala Met
Leu Lys Ala Ala Asn Gln 530 535 540 Tyr Asn Gly Lys Ala Glu Leu Pro
His Ser Val Phe His Gly His Lys 545 550 555 560 Gln Leu Ala Thr Lys
Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 565 570 575 Leu Tyr Thr
Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 580 585 590 Asn
Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 595 600
605 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu
610 615 620 Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp
Asp Ala 625 630 635 640 Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg
Glu Ser Lys Thr Leu 645 650 655 Ser Asn Lys Lys Lys Glu Tyr Leu Leu
Thr Glu Glu Asp Ile Ser Lys 660 665 670 Phe Asp Val Arg Lys Lys Phe
Ile Glu Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Ala Ser Arg Val
Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 690 695 700 His Lys Ile
Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 705 710 715 720
Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 725
730 735 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu
Asn 740 745 750 Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser
Glu Asp Gln 755 760 765 Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser
Asp Asp Glu Tyr Lys 770 775 780 Glu Ser Val Phe Lys Ala Pro Tyr Gln
His Phe Val Asp Thr Leu Lys 785 790 795 800 Ser Lys Glu Phe Glu Asp
Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 805 810 815 Lys Phe Asn Arg
Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 820 825 830 Ala Lys
Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 835 840 845
Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 850
855 860 Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro
Gln 865 870 875 880 Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn
Tyr Pro Asn Lys 885 890 895 Gln Ile Asn Glu Lys Gly Lys Glu Val Pro
Cys Asn Pro Phe Leu Lys 900 905 910 Tyr Lys Glu Glu His Gly Tyr Ile
Arg Lys Tyr Ser Lys Lys Gly Asn 915 920 925 Gly Pro Glu Ile Lys Ser
Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 930 935 940 His Ile Asp Ile
Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 945 950 955 960 Ser
Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 965 970
975 Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys
980 985 990 Gly Thr Gly Thr Tyr Lys Ile Ser Gln Glu Lys Tyr Asn Asp
Ile Lys 995 1000 1005 Lys Lys Glu Gly Val Asp Ser Asp Ser Glu Phe
Lys Phe Thr Leu 1010 1015 1020 Tyr Lys Asn Asp Leu Leu Leu Val Lys
Asp Thr Glu Thr Lys Glu 1025 1030 1035 Gln Gln Leu Phe Arg Phe Leu
Ser Arg Thr
Met Pro Lys Gln Lys 1040 1045 1050 His Tyr Val Glu Leu Lys Pro Tyr
Asp Lys Gln Lys Phe Glu Gly 1055 1060 1065 Gly Glu Ala Leu Ile Lys
Val Leu Gly Asn Val Ala Asn Ser Gly 1070 1075 1080 Gln Cys Lys Lys
Gly Leu Gly Lys Ser Asn Ile Ser Ile Tyr Lys 1085 1090 1095 Val Arg
Thr Asp Val Leu Gly Asn Gln His Ile Ile Lys Asn Glu 1100 1105 1110
Gly Asp Lys Pro Lys Leu Met 1115 1120 1993477DNAArtificial
SequenceDescription of Artificial Sequence Synthetic polynucleotide
199accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa
gaaaaagcgc 60aaggtcgaag cgtcctccga cctggtactt ggactggata ttggtatcgg
ttcggtggga 120gtcggaatcc tcaacaaggt cacgggggag atcattcaca
agaactcgcg gatcttcccc 180gcagctcagg ctgagaacaa cttggtgcgg
agaacgaata ggcagggcag gcgactggcg 240aggaggaaga aacacaggag
agtccgattg aaccggctgt tcgaggagtc cggtttgatc 300accgacttta
cgaaaatctc gattaacctt aatccctatc agcttcgggt gaaaggcctg
360acagacgaac tttcgaatga ggaacttttc atcgcgctga aaaacatggt
caagcacaga 420gggatttcct acctcgatga cgcctcggat gacggaaatt
cctcagtagg agattatgca 480cagatcgtga aagagaactc aaagcaactg
gaaacaaaga caccggggca gatccaactt 540gaaagatacc agacatacgg
acagctcaga ggagatttta cggtggagaa ggacggtaaa 600aagcacagac
tcattaacgt atttcccacg tcggcgtaca gatccgaagc gctccgcatc
660cttcagactc aacaggagtt caacccgcaa attactgatg agttcatcaa
ccgctatttg 720gaaatcttga ccggaaagcg caagtattat catgggccgg
gtaatgagaa atccagaaca 780gattacggcc gatacagaac ttcgggggaa
accttggata acatctttgg tattttgatt 840ggaaagtgca ccttttaccc
ggacgagttt cgagcggcca aggcgtcata cacagcacaa 900gagtttaatc
tcttgaatga tttgaacaac ttgacggtcc ccacggagac aaagaagctc
960tccaaagagc aaaagaacca aatcatcaac tacgtcaaga acgagaaggc
tatggggcca 1020gcgaagctgt tcaagtatat cgctaaactt ctcagctgtg
atgtggcgga catcaaaggg 1080taccgaatcg acaagtcggg aaaagcggaa
attcacacgt ttgaagcata tcgaaagatg 1140aaaacgttgg aaacactgga
cattgagcag atggaccggg aaacgctcga caaactggca 1200tacgtgctca
cgttgaatac tgaacgagag ggaatccaag aggcccttga acatgagttc
1260gccgatggat cgttcagcca gaagcaggtc gacgaacttg tgcaattccg
caaggcgaat 1320agctccatct tcgggaaggg atggcacaac ttttcggtca
aactcatgat ggagttgatc 1380ccagaacttt atgagacttc ggaggagcaa
atgacgatct tgacgcgctt ggggaaacag 1440aaaacgacaa gctcatcgaa
caaaactaag tacattgatg agaaattgct gacggaagaa 1500atctataatc
cggtagtagc gaaatcggta agacaagcga tcaaaatcgt gaacgcggcg
1560atcaaggaat atggtgactt tgataacatc gtaattgaaa tggctagaga
gacgaacgaa 1620gatgacgaga aaaaggcaat ccagaagatc cagaaggcca
acaaggatga aaaagatgca 1680gcgatgctta aagcggccaa ccaatacaat
ggaaaggcgg agctgcccca ttcagtgttt 1740cacggtcata aacagttggc
gaccaagatc cgactctggc atcagcaggg tgagcggtgt 1800ctctacaccg
gaaagactat ctccatccat gacttgatta acaattcgaa ccagtttgaa
1860gtggatcata ttctgcccct gtcaatcacc tttgacgact cgcttgcgaa
caaggtgctc 1920gtgtacgcaa cggcaaatca ggagaaaggc cagcggactc
cgtatcaggc gctcgactca 1980atggacgatg cgtggtcatt ccgggagctg
aaggcgttcg tacgcgagag caagacactg 2040agcaacaaaa agaaagagta
tctgctgaca gaggaggaca tctcgaaatt cgatgtcagg 2100aagaagttca
tcgagcggaa tcttgtcgac actcgctacg cttccagagt agtactgaac
2160gcgctccagg aacactttag agcgcacaaa attgacacga aggtgtcagt
ggtgagaggg 2220cagttcacat cccaactccg ccgacattgg ggcatcgaaa
agacgcggga cacatatcac 2280catcatgcgg tggacgcgct gattattgcc
gcttcgtccc agttgaatct ctggaaaaag 2340cagaagaaca cgctggtgtc
gtattcggag gatcagcttt tggacatcga aaccggggag 2400ctgatttccg
acgatgaata caaagaatcg gtgtttaagg caccatatca gcatttcgtg
2460gacacgctga agagcaaaga gtttgaggac agcatcctct tttcgtacca
agtggactcg 2520aagtttaatc gcaagatttc agacgccaca atctacgcga
cgaggcaggc gaaggtgggc 2580aaagataaag cagatgaaac ctacgtcctt
ggtaaaatca aggacatcta cactcaggac 2640gggtacgatg cgttcatgaa
aatctacaag aaggataagt cgaagtttct catgtaccgc 2700cacgatccac
agactttcga aaaagtcatt gagcctattt tggagaacta ccctaacaag
2760caaatcaacg agaaagggaa agaagtcccg tgcaacccct ttctgaagta
caaggaagag 2820cacggttata tccgcaaata ctcgaagaaa ggaaatgggc
ctgagattaa gtcgcttaag 2880tattacgact caaagttggg taaccacatc
gacattaccc cgaaagactc caacaacaaa 2940gtcgtgttgc agtccgtctc
gccctggcga gcagatgtgt attttaataa gacgaccggc 3000aaatatgaga
tccttggact caaatacgca gaccttcaat tcgaaaaggg gacgggcact
3060tataagattt cacaagagaa gtacaacgac atcaagaaaa aggaaggggt
cgattcagat 3120tcggagttca aattcaccct ctacaaaaac gacctcctgc
ttgtgaagga cacagaaacg 3180aaggagcagc agctctttcg gttcctctca
cgcacgatgc ccaaacaaaa acattacgtc 3240gaacttaaac cttacgataa
gcaaaagttt gaagggggag aggcactgat caaagtattg 3300ggtaacgtag
ccaatagcgg acagtgtaag aaagggctgg gaaagtccaa tatctcgatc
3360tataaagtac gaacagatgt attgggaaac cagcatatca tcaaaaatga
gggggataaa 3420cccaaactcg atttcagccc caagaagaag agaaaggtgg
aggccagcta agaattc 347720027DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 200gcccgggtgg
aactggtagc catgaat 2720126DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 201gttgaagatg
aagcccagag cggagt 2620227DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 202gcttccgacg
aggtggccat caaggat 2720327DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 203gcaccatctc
tccgtggtac cccgggt 2720426DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 204ggtggaactg
gtagccatga atgaga 2620527DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 205gccatgaatg
agaccgaccc aaagagc 2720627DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 206gcatcctcgt
gggcacttcc gacgagg 2720727DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 207gcagagcgga
gtgctgttct cccaagt 2720826DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 208ggtcggtctc
attcatggct accagt 2620926DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 209gcaataaaag
gtgctattgc tatagt 2621026DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 210gtactcaacc
aagtcattct gagaat 2621126DNAArtificial SequenceDescription of
Artificial Sequence Synthetic oligonucleotide 211nnnnnnngta
ctcaaccaag tcattc 262121121PRTStreptococcus thermophilus 212Met Ser
Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 1 5 10 15
Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 20
25 30 Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg
Thr 35 40 45 Asn Arg Gln Gly Arg Arg Leu Ala Arg Arg Lys Lys His
Arg Arg Val 50 55 60 Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu
Ile Thr Asp Phe Thr 65 70 75 80 Lys Ile Ser Ile Asn Leu Asn Pro Tyr
Gln Leu Arg Val Lys Gly Leu 85 90 95 Thr Asp Glu Leu Ser Asn Glu
Glu Leu Phe Ile Ala Leu Lys Asn Met 100 105 110 Val Lys His Arg Gly
Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 115 120 125 Asn Ser Ser
Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 130 135 140 Gln
Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 145 150
155 160 Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly
Lys 165 170 175 Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr
Arg Ser Glu 180 185 190 Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe
Asn Pro Gln Ile Thr 195 200 205 Asp Glu Phe Ile Asn Arg Tyr Leu Glu
Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn
Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230 235 240 Tyr Arg Thr Ser
Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 245 250 255 Gly Lys
Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 260 265 270
Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275
280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln
Ile 290 295 300 Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala
Lys Leu Phe 305 310 315 320 Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp
Val Ala Asp Ile Lys Gly 325 330 335 Tyr Arg Ile Asp Lys Ser Gly Lys
Ala Glu Ile His Thr Phe Glu Ala 340 345 350 Tyr Arg Lys Met Lys Thr
Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 355 360 365 Arg Glu Thr Leu
Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu
Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 385 390 395
400 Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn
405 410 415 Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys
Leu Met 420 425 430 Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu
Glu Gln Met Thr 435 440 445 Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr
Thr Ser Ser Ser Asn Lys 450 455 460 Thr Lys Tyr Ile Asp Glu Lys Leu
Leu Thr Glu Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ala Lys Ser
Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 485 490 495 Ile Lys Glu
Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 500 505 510 Glu
Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 515 520
525 Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln
530 535 540 Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly
His Lys 545 550 555 560 Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln
Gln Gly Glu Arg Cys 565 570 575 Leu Tyr Thr Gly Lys Thr Ile Ser Ile
His Asp Leu Ile Asn Asn Ser 580 585 590 Asn Gln Phe Glu Val Asp His
Ile Leu Pro Leu Ser Ile Thr Phe Asp 595 600 605 Asp Ser Leu Ala Asn
Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 610 615 620 Lys Gly Gln
Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 625 630 635 640
Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 645
650 655 Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser
Lys 660 665 670 Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val
Asp Thr Arg 675 680 685 Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln
Glu His Phe Arg Ala 690 695 700 His Lys Ile Asp Thr Lys Val Ser Val
Val Arg Gly Gln Phe Thr Ser 705 710 715 720 Gln Leu Arg Arg His Trp
Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 725 730 735 His His Ala Val
Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 740 745 750 Leu Trp
Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 755 760 765
Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 770
775 780 Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu
Lys 785 790 795 800 Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr
Gln Val Asp Ser 805 810 815 Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr
Ile Tyr Ala Thr Arg Gln 820 825 830 Ala Lys Val Gly Lys Asp Lys Ala
Asp Glu Thr Tyr Val Leu Gly Lys 835 840 845 Ile Lys Asp Ile Tyr Thr
Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 850 855 860 Tyr Lys Lys Asp
Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 865 870 875 880 Thr
Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 885 890
895 Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys
900 905 910 Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys
Gly Asn 915 920 925 Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser
Lys Leu Gly Asn 930 935 940 His Ile Asp Ile Thr Pro Lys Asp Ser Asn
Asn Lys Val Val Leu Gln 945 950 955 960 Ser Val Ser Pro Trp Arg Ala
Asp Val Tyr Phe Asn Lys Thr Thr Gly 965 970 975 Lys Tyr Glu Ile Leu
Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 980 985 990 Gly Thr Gly
Thr Tyr Lys Ile Ser Gln Glu Lys Tyr Asn Asp Ile Lys 995 1000 1005
Lys Lys Glu Gly Val Asp Ser Asp Ser Glu Phe Lys Phe Thr Leu 1010
1015 1020 Tyr Lys Asn Asp Leu Leu Leu Val Lys Asp Thr Glu Thr Lys
Glu 1025 1030 1035 Gln Gln Leu Phe Arg Phe Leu Ser Arg Thr Met Pro
Lys Gln Lys 1040 1045 1050 His Tyr Val Glu Leu Lys Pro Tyr Asp Lys
Gln Lys Phe Glu Gly 1055 1060 1065 Gly Glu Ala Leu Ile Lys Val Leu
Gly Asn Val Ala Asn Ser Gly 1070 1075 1080 Gln Cys Lys Lys Gly Leu
Gly Lys Ser Asn Ile Ser Ile Tyr Lys 1085 1090 1095 Val Arg Thr Asp
Val Leu Gly Asn Gln His Ile Ile Lys Asn Glu 1100 1105 1110 Gly Asp
Lys Pro Lys Leu Asp Phe 1115 1120 21320DNACorynebacter diphtheriae
213aaaagggaat aagggcgaca 2021427DNASutterella
wadsworthensismodified_base(1)..(1)a, c, t, g, unknown or other
214nggnnnncat tctgagaata gtgtatg 2721520DNASutterella
wadsworthensis 215gcgaccgagt tgctcttgcc 2021627DNALegionella
pneumophilamodified_base(1)..(1)a, c, t, g, unknown or other
216nggnnnncat tctgagaata gtgtatg 2721720DNALegionella pneumophila
217gcgaccgagt tgctcttgcc 2021827DNAFilifactor
alocismodified_base(1)..(3)a, c, t, g, unknown or other
218nnnaagcttg agtactcacc agtcaca 2721920DNAFilifactor alocis
219ctcttccttt ttcaatatta 2022027DNALactobacillus
johnsoniimodified_base(1)..(2)a, c, t, g, unknown or other
220nnaaanntaa atgcttcaat aatattg 2722120DNALactobacillus johnsonii
221aaagggaata agggcgacac 2022227DNAParvibaculum
lavamentivoransmodified_base(1)..(3)a, c, t, g, unknown or other
222nnncatnaaa ggaagagtat gagtatt 2722320DNAStaphylococcus aureus
223ctattctcag aatgacttgg 2022427DNAMycoplasma
gallisepticummodified_base(1)..(2)a, c, t, g, unknown or other
224nnganggagt cacagaaaag catctta 2722520DNAMycoplasma gallisepticum
225gtttctgggt gagcaaaaac 2022627DNACampylobacter
larimodified_base(1)..(2)a, c, t, g, unknown or other 226nngggnagaa
ggcaaaatgc cgcaaaa 2722720DNACampylobacter lari 227ggtattatcc
cgtattgacg 2022820DNAUnknownDescription of Unknown
SpCas9 oligonucleotide 228gggactcaac caagtcattc 20
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