U.S. patent application number 15/321650 was filed with the patent office on 2017-07-13 for multispecific nkp46 binding proteins. The applicant listed for this patent is INNATE PHARMA. Invention is credited to Nadia ANCERIZ, Laurent GAUTHIER, Ariane MOREL, Benjamin ROSSI.
Application Number | 20170198038 15/321650 |
Document ID | / |
Family ID | 53488321 |
Filed Date | 2017-07-13 |
United States Patent Application | 20170198038 |
Kind Code | A1 |
GAUTHIER; Laurent ; et al. | July 13, 2017 |
Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
Inventors: | GAUTHIER; Laurent; (Marseille, FR) ; ANCERIZ; Nadia; (Aubagne, FR) ; MOREL; Ariane; (Marseille, FR) ; ROSSI; Benjamin; (Marseille, FR) | ||||||||||
Applicant: |
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Family ID: | 53488321 | ||||||||||
Appl. No.: | 15/321650 | ||||||||||
Filed: | June 23, 2015 | ||||||||||
PCT Filed: | June 23, 2015 | ||||||||||
PCT NO: | PCT/EP2015/064063 | ||||||||||
371 Date: | December 22, 2016 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
62017886 | Jun 27, 2014 | |||
62108088 | Jan 27, 2015 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | C07K 16/2803 20130101; A61P 35/00 20180101; A61P 29/00 20180101; A61P 31/00 20180101; C07K 2319/30 20130101; C07K 2317/71 20130101; C07K 2317/92 20130101; C07K 16/2866 20130101; A61P 37/02 20180101; C07K 2317/31 20130101 |
International Class: | C07K 16/28 20060101 C07K016/28 |
Sequence CWU 1 SEQUENCE LISTING <160> NUMBER OF SEQ ID
NOS: 187 <210> SEQ ID NO 1 <211> LENGTH: 304
<212> TYPE: PRT <213> ORGANISM: homo sapiens
<400> SEQUENCE: 1 Met Ser Ser Thr Leu Pro Ala Leu Leu Cys Val
Gly Leu Cys Leu Ser 1 5 10 15 Gln Arg Ile Ser Ala Gln Gln Gln Thr
Leu Pro Lys Pro Phe Ile Trp 20 25 30 Ala Glu Pro His Phe Met Val
Pro Lys Glu Lys Gln Val Thr Ile Cys 35 40 45 Cys Gln Gly Asn Tyr
Gly Ala Val Glu Tyr Gln Leu His Phe Glu Gly 50 55 60 Ser Leu Phe
Ala Val Asp Arg Pro Lys Pro Pro Glu Arg Ile Asn Lys 65 70 75 80 Val
Lys Phe Tyr Ile Pro Asp Met Asn Ser Arg Met Ala Gly Gln Tyr 85 90
95 Ser Cys Ile Tyr Arg Val Gly Glu Leu Trp Ser Glu Pro Ser Asn Leu
100 105 110 Leu Asp Leu Val Val Thr Glu Met Tyr Asp Thr Pro Thr Leu
Ser Val 115 120 125 His Pro Gly Pro Glu Val Ile Ser Gly Glu Lys Val
Thr Phe Tyr Cys 130 135 140 Arg Leu Asp Thr Ala Thr Ser Met Phe Leu
Leu Leu Lys Glu Gly Arg 145 150 155 160 Ser Ser His Val Gln Arg Gly
Tyr Gly Lys Val Gln Ala Glu Phe Pro 165 170 175 Leu Gly Pro Val Thr
Thr Ala His Arg Gly Thr Tyr Arg Cys Phe Gly 180 185 190 Ser Tyr Asn
Asn His Ala Trp Ser Phe Pro Ser Glu Pro Val Lys Leu 195 200 205 Leu
Val Thr Gly Asp Ile Glu Asn Thr Ser Leu Ala Pro Glu Asp Pro 210 215
220 Thr Phe Pro Ala Asp Thr Trp Gly Thr Tyr Leu Leu Thr Thr Glu Thr
225 230 235 240 Gly Leu Gln Lys Asp His Ala Leu Trp Asp His Thr Ala
Gln Asn Leu 245 250 255 Leu Arg Met Gly Leu Ala Phe Leu Val Leu Val
Ala Leu Val Trp Phe 260 265 270 Leu Val Glu Asp Trp Leu Ser Arg Lys
Arg Thr Arg Glu Arg Ala Ser 275 280 285 Arg Ala Ser Thr Trp Glu Gly
Arg Arg Arg Leu Asn Thr Gln Thr Leu 290 295 300 <210> SEQ ID
NO 2 <211> LENGTH: 216 <212> TYPE: PRT <213>
ORGANISM: homo sapiens <400> SEQUENCE: 2 Ala Pro Glu Leu Leu
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40
45 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
50 55 60 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys 85 90 95 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg Glu Glu Met 115 120 125 Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170
175 Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
180 185 190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Pro Gly 210 215
<210> SEQ ID NO 3 <211> LENGTH: 120 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 3 Gln
Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 1 5 10
15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30 Val Ile Asn Trp Gly Lys Gln Arg Ser Gly Gln Gly Leu Glu
Trp Ile 35 40 45 Gly Glu Ile Tyr Pro Gly Ser Gly Thr Asn Tyr Tyr
Asn Glu Lys Phe 50 55 60 Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys
Ser Ser Asn Ile Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Ser
Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Arg Gly Arg Tyr
Gly Leu Tyr Ala Met Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Ser Val
Thr Val Ser Ser 115 120 <210> SEQ ID NO 4 <211> LENGTH:
107 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 4 Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala
Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys
Pro Asp Gly Thr Val Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg
Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser
Gly Thr Asp Tyr Ser Leu Thr Ile Asn Asn Leu Glu Gln 65 70 75 80 Glu
Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Arg Pro Trp 85 90
95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210>
SEQ ID NO 5 <211> LENGTH: 122 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 5 Glu Val
Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 20
25 30 Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu
Trp 35 40 45 Met Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn
Pro Ser Leu 50 55 60 Glu Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser
Thr Asn Gln Phe Phe 65 70 75 80 Leu Gln Leu Asn Ser Val Thr Thr Glu
Asp Thr Ala Thr Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Tyr Tyr Gly
Ser Ser Trp Gly Val Phe Ala Tyr Trp 100 105 110 Gly Gln Gly Thr Leu
Val Thr Val Ser Ala 115 120 <210> SEQ ID NO 6 <211>
LENGTH: 107 <212> TYPE: PRT <213> ORGANISM: Mus
musculus <400> SEQUENCE: 6 Asp Ile Gln Met Thr Gln Ser Pro
Ala Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Glu Thr Val Thr Ile Thr
Cys Arg Val Ser Glu Asn Ile Tyr Ser Tyr 20 25 30 Leu Ala Trp Tyr
Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 35 40 45 Tyr Asn
Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 65
70 75 80 Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr
Pro Trp 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100
105 <210> SEQ ID NO 7 <211> LENGTH: 116 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
7 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 1
5 10 15 Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu
Tyr 20 25 30 Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu
Glu Trp Ile 35 40 45 Gly Gly Ile Ser Pro Asn Ile Gly Gly Thr Ser
Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Val Asp
Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Thr
Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Arg Gly Gly
Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 100 105 110 Thr Val Ser
Ser 115 <210> SEQ ID NO 8 <211> LENGTH: 107 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
8 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 1
5 10 15 Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp
Tyr 20 25 30 Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg
Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro
Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ser Asp Phe Thr Leu
Ser Ile Asn Ser Val Glu Pro 65 70 75 80 Glu Asp Val Gly Val Tyr Tyr
Cys Gln Asn Gly His Ser Phe Pro Leu 85 90 95 Thr Phe Gly Ala Gly
Thr Lys Leu Glu Leu Lys 100 105 <210> SEQ ID NO 9 <211>
LENGTH: 117 <212> TYPE: PRT <213> ORGANISM: Mus
musculus <400> SEQUENCE: 9 Gln Val Gln Leu Gln Gln Ser Ala
Val Glu Leu Ala Arg Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 20 25 30 Thr Met His Trp
Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr
Ile Asn Pro Ser Ser Gly Tyr Thr Glu Tyr Asn Gln Lys Phe 50 55 60
Lys Asp Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 65
70 75 80 Met Gln Leu Asp Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr
Tyr Cys 85 90 95 Val Arg Gly Ser Ser Arg Gly Phe Asp Tyr Trp Gly
Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ala 115 <210> SEQ
ID NO 10 <211> LENGTH: 107 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 10 Asp Ile Gln Met Ile
Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 1 5 10 15 Glu Thr Val
Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 20 25 30 Leu
Ala Trp Phe Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 35 40
45 Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60 Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu
Gln Ser 65 70 75 80 Glu Asp Phe Gly Ile Tyr Tyr Cys Gln His Phe Trp
Gly Thr Pro Arg 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
Lys 100 105 <210> SEQ ID NO 11 <211> LENGTH: 115
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 11 Gln Val Gln Leu Gln Gln Pro Gly Ser Val
Leu Val Arg Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Ser 20 25 30 Trp Met His Trp Ala Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly His Ile His
Pro Asn Ser Gly Ile Ser Asn Tyr Asn Glu Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80
Val Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Gly Gly Arg Phe Asp Asp Trp Gly Ala Gly Thr Thr Val
Thr 100 105 110 Val Ser Ser 115 <210> SEQ ID NO 12
<211> LENGTH: 108 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 12 Asp Ile Val Met Thr Gln Ser
Pro Ala Thr Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu
Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp
Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys
Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55
60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro
65 70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe
Leu Met 85 90 95 Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 <210> SEQ ID NO 13 <211> LENGTH: 120
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 13 Asp Val Gln Leu Gln Glu Ser Gly Pro Gly
Leu Val Lys Pro Ser Gln 1 5 10 15 Ser Leu Ser Leu Thr Cys Thr Val
Thr Gly Tyr Ser Ile Thr Ser Asp 20 25 30 Tyr Ala Trp Asn Trp Ile
Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 35 40 45 Met Gly Tyr Ile
Thr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 50 55 60 Lys Ser
Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 65 70 75 80
Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 85
90 95 Ala Arg Cys Trp Asp Tyr Ala Leu Tyr Ala Met Asp Cys Trp Gly
Gln 100 105 110 Gly Thr Ser Val Thr Val Ser Ser 115 120 <210>
SEQ ID NO 14 <211> LENGTH: 107 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 14 Asp Ile
Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr 20
25 30 Leu Ala Trp Cys Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu
Val 35 40 45 Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg
Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr His Phe Ser Leu Lys Ile
Asn Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Gly Ile Tyr Tyr Cys Gln
His His Tyr Asp Thr Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys
Leu Glu Leu Lys 100 105 <210> SEQ ID NO 15 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 15 Asp Tyr Val Ile Asn 1 5 <210> SEQ ID
NO 16 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: mus musculus <400> SEQUENCE: 16 Gly Tyr Thr Phe Thr
Asp Tyr 1 5 <210> SEQ ID NO 17 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 17 Gly Tyr Thr Phe Thr Asp Tyr Val 1 5
<210> SEQ ID NO 18 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 18 Glu
Ile Tyr Pro Gly Ser Gly Thr Asn Tyr Tyr Asn Glu Lys Phe Lys 1 5 10
15 Ala <210> SEQ ID NO 19 <211> LENGTH: 4 <212>
TYPE: PRT <213> ORGANISM: mus musculus <400> SEQUENCE:
19 Pro Gly Ser Gly 1 <210> SEQ ID NO 20 <211> LENGTH:
16 <212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 20 Gly Tyr Thr Phe Thr Asp Tyr Val Ile Tyr
Pro Gly Ser Gly Thr Asn 1 5 10 15 <210> SEQ ID NO 21
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
mus musculus <400> SEQUENCE: 21 Arg Gly Arg Tyr Gly Leu Tyr
Ala Met Asp Tyr 1 5 10 <210> SEQ ID NO 22 <211> LENGTH:
9 <212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 22 Gly Arg Tyr Gly Leu Tyr Ala Met Asp 1 5
<210> SEQ ID NO 23 <211> LENGTH: 13 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 23 Ala
Arg Arg Gly Arg Tyr Gly Leu Tyr Ala Met Asp Tyr 1 5 10 <210>
SEQ ID NO 24 <211> LENGTH: 11 <212> TYPE: PRT
<213> ORGANISM: mus musculus <400> SEQUENCE: 24 Arg Ala
Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> SEQ ID NO 25
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 25 Ser Gln Asp Ile Ser Asn Tyr 1
5 <210> SEQ ID NO 26 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 26 Gln
Asp Ile Ser Asn Tyr 1 5 <210> SEQ ID NO 27 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 27 Tyr Thr Ser Arg Leu His Ser 1 5
<210> SEQ ID NO 28 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 28 Gln
Gln Gly Asn Thr Arg Pro Trp Thr 1 5 <210> SEQ ID NO 29
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 29 Tyr Thr Ser Gly Asn Thr Arg
Pro Trp 1 5 <210> SEQ ID NO 30 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 30 Tyr Thr Ser Gln Gln Gly Asn Thr Arg Pro
Trp Thr 1 5 10 <210> SEQ ID NO 31 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 31 Ser Asp Tyr Ala Trp Asn 1 5 <210>
SEQ ID NO 32 <211> LENGTH: 8 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 32 Gly Tyr
Ser Ile Thr Ser Asp Tyr 1 5 <210> SEQ ID NO 33 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 33 Gly Tyr Ser Ile Thr Ser Asp Tyr Ala 1 5
<210> SEQ ID NO 34 <211> LENGTH: 16 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 34 Tyr
Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Glu Ser 1 5 10
15 <210> SEQ ID NO 35 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 35 Ile
Thr Tyr Ser Gly Ser Thr 1 5 <210> SEQ ID NO 36 <211>
LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 36 Gly Gly Tyr Tyr Gly Ser Ser Trp Gly Val
Phe Ala Tyr 1 5 10 <210> SEQ ID NO 37 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 37 Gly Tyr Tyr Gly Ser Ser Trp Gly Val Phe
Ala 1 5 10 <210> SEQ ID NO 38 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 38 Ala Arg Gly Gly Tyr Tyr Gly Ser Ser Trp
Gly Val Phe Ala Tyr 1 5 10 15 <210> SEQ ID NO 39 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 39 Arg Val Ser Glu Asn Ile Tyr Ser Tyr Leu
Ala 1 5 10 <210> SEQ ID NO 40 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 40 Ser Glu Asn Ile Tyr Ser Tyr 1 5
<210> SEQ ID NO 41 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 41 Glu
Asn Ile Tyr Ser Tyr 1 5 <210> SEQ ID NO 42 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 42 Asn Ala Lys Thr Leu Ala Glu 1 5
<210> SEQ ID NO 43 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 43 Gln
His His Tyr Gly Thr Pro Trp Thr 1 5 <210> SEQ ID NO 44
<211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 44 His Tyr Gly Thr Pro Trp 1 5
<210> SEQ ID NO 45 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 45 Gln
His His Tyr Gly Thr Pro Trp Thr 1 5 <210> SEQ ID NO 46
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 46 Glu Tyr Thr Met His 1 5
<210> SEQ ID NO 47 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 47 Gly
Tyr Thr Phe Thr Glu Tyr 1 5 <210> SEQ ID NO 48 <211>
LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 48 Gly Tyr Thr Phe Thr Glu Tyr Thr 1 5
<210> SEQ ID NO 49 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 49 Gly
Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 1 5 10
15 Gly <210> SEQ ID NO 50 <211> LENGTH: 8 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
50 Ile Ser Pro Asn Ile Gly Gly Thr 1 5 <210> SEQ ID NO 51
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 51 Arg Gly Gly Ser Phe Asp Tyr 1
5 <210> SEQ ID NO 52 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 52 Gly
Gly Ser Phe Asp 1 5 <210> SEQ ID NO 53 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 53 Ala Arg Arg Gly Gly Ser Phe Asp Tyr 1 5
<210> SEQ ID NO 54 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 54 Arg
Ala Ser Gln Ser Ile Ser Asp Tyr Leu His 1 5 10 <210> SEQ ID
NO 55 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 55 Ser Gln Ser Ile Ser
Asp Tyr 1 5 <210> SEQ ID NO 56 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 56 Gln Ser Ile Ser Asp Tyr 1 5 <210>
SEQ ID NO 57 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 57 Tyr Ala
Ser Gln Ser Ile Ser 1 5 <210> SEQ ID NO 58 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 58 Gln Asn Gly His Ser Phe Pro Leu Thr 1 5
<210> SEQ ID NO 59 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 59 Gly
His Ser Phe Pro Leu 1 5 <210> SEQ ID NO 60 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 60 Ser Phe Thr Met His 1 5 <210> SEQ ID
NO 61 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 61 Gly Tyr Thr Phe Thr
Ser Phe 1 5 <210> SEQ ID NO 62 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 62 Gly Tyr Thr Phe Thr Ser Phe Thr 1 5
<210> SEQ ID NO 63 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 63 Tyr
Ile Asn Pro Ser Ser Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys 1 5 10
15 Asp <210> SEQ ID NO 64 <211> LENGTH: 8 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
64 Ile Asn Pro Ser Ser Gly Tyr Thr 1 5 <210> SEQ ID NO 65
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 65 Gly Ser Ser Arg Gly Phe Asp
Tyr 1 5 <210> SEQ ID NO 66 <211> LENGTH: 6 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
66 Ser Ser Arg Gly Phe Asp 1 5 <210> SEQ ID NO 67 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 67 Val Arg Gly Ser Ser Arg Gly Phe Asp Tyr 1
5 10 <210> SEQ ID NO 68 <211> LENGTH: 11 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
68 Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 1 5 10 <210>
SEQ ID NO 69 <211> LENGTH: 6 <212> TYPE: PRT
<213> ORGANISM: Mus musculur <400> SEQUENCE: 69 Glu Asn
Ile Tyr Ser Asn 1 5 <210> SEQ ID NO 70 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: mus musculur
<400> SEQUENCE: 70 Ala Ala Thr Asn Leu Ala Asp 1 5
<210> SEQ ID NO 71 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 71 Gln
His Phe Trp Gly Thr Pro Arg Thr 1 5 <210> SEQ ID NO 72
<211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 72 Phe Trp Gly Thr Pro Arg 1 5
<210> SEQ ID NO 73 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 73 Ser
Ser Trp Met His 1 5 <210> SEQ ID NO 74 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 74 Gly Tyr Thr Phe Thr Ser Ser 1 5
<210> SEQ ID NO 75 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 75 Gly
Tyr Thr Phe Thr Ser Ser Trp 1 5 <210> SEQ ID NO 76
<211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 76 His Ile His Pro Asn Ser Gly
Ile Ser Asn Tyr Asn Glu Lys Phe Lys 1 5 10 15 Gly <210> SEQ
ID NO 77 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 77 Ile His Pro Asn Ser
Gly Ile Ser 1 5 <210> SEQ ID NO 78 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 78 Gly Gly Arg Phe Asp Asp 1 5 <210>
SEQ ID NO 79 <211> LENGTH: 8 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 79 Ala Arg
Gly Gly Arg Phe Asp Asp 1 5 <210> SEQ ID NO 80 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 80 Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu
His 1 5 10 <210> SEQ ID NO 81 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 81 Gly Arg Phe Asp Ser Gln Ser Ile Ser Asp
Tyr 1 5 10 <210> SEQ ID NO 82 <211> LENGTH: 10
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 82 Gln Asn Gly His Ser Phe Leu Met Tyr Thr 1
5 10 <210> SEQ ID NO 83 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
83 Gly His Ser Phe Leu Met Tyr 1 5 <210> SEQ ID NO 84
<211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 84 Tyr Ala Ser Gln Asn Gly His
Ser Phe Leu Met Tyr Thr 1 5 10 <210> SEQ ID NO 85 <211>
LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 85 Ser Asp Tyr Ala Trp Asn 1 5 <210>
SEQ ID NO 86 <211> LENGTH: 8 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 86 Gly Tyr
Ser Ile Thr Ser Asp Tyr 1 5 <210> SEQ ID NO 87 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 87 Gly Tyr Ser Ile Thr Ser Asp Tyr Ala 1 5
<210> SEQ ID NO 88 <211> LENGTH: 16 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 88 Tyr
Ile Thr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10
15 <210> SEQ ID NO 89 <211> LENGTH: 11 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
89 Cys Trp Asp Tyr Ala Leu Tyr Ala Met Asp Cys 1 5 10 <210>
SEQ ID NO 90 <211> LENGTH: 9 <212> TYPE: PRT
<213> ORGANISM: mus musculus <400> SEQUENCE: 90 Trp Asp
Tyr Ala Leu Tyr Ala Met Asp 1 5 <210> SEQ ID NO 91
<211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 91 Ala Arg Cys Trp Asp Tyr Ala
Leu Tyr Ala Met Asp Cys 1 5 10 <210> SEQ ID NO 92 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 92 Arg Thr Ser Glu Asn Ile Tyr Ser Tyr Leu
Ala 1 5 10 <210> SEQ ID NO 93 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 93 Asn Ala Lys Thr Leu Ala Glu 1 5
<210> SEQ ID NO 94 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 94 Gln
His His Tyr Asp Thr Pro Leu Thr 1 5 <210> SEQ ID NO 95
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
mus musculus <400> SEQUENCE: 95 Asn Ala Lys His Tyr Asp Thr
Pro Leu 1 5 <210> SEQ ID NO 96 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 96 Gln His His Tyr Asp Thr Pro Leu Thr 1 5
<210> SEQ ID NO 97 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 97 Asn
Tyr Gly Met Asn 1 5 <210> SEQ ID NO 98 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 98 Gly Tyr Thr Phe Thr Asn Tyr 1 5
<210> SEQ ID NO 99 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 99 Gly
Tyr Thr Phe Thr Asn Tyr Gly 1 5 <210> SEQ ID NO 100
<211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM:
mus musculus <400> SEQUENCE: 100 Trp Ile Asn Thr Asn Thr Gly
Glu Pro Thr Tyr Ala Glu Glu Phe Lys 1 5 10 15 Gly <210> SEQ
ID NO 101 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 101 Ile Asn Thr Asn
Thr Gly Glu Pro 1 5 <210> SEQ ID NO 102 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 102 Asp Tyr Leu Tyr Tyr Phe Asp Tyr 1 5
<210> SEQ ID NO 103 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 103
Tyr Leu Tyr Tyr Phe Asp 1 5 <210> SEQ ID NO 104 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 104 Ala Arg Asp Tyr Leu Tyr Tyr Phe Asp Tyr 1
5 10 <210> SEQ ID NO 105 <211> LENGTH: 11 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
105 Lys Ala Ser Glu Asn Val Val Thr Tyr Val Ser 1 5 10 <210>
SEQ ID NO 106 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 106 Ser
Glu Asn Val Val Thr Tyr 1 5 <210> SEQ ID NO 107 <211>
LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 107 Glu Asn Val Val Thr Tyr 1 5 <210>
SEQ ID NO 108 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 108 Gly
Ala Ser Asn Arg Tyr Thr 1 5 <210> SEQ ID NO 109 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 109 Gly Gln Gly Tyr Ser Tyr Pro Tyr Thr 1 5
<210> SEQ ID NO 110 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 110
Gly Tyr Ser Tyr Pro Tyr 1 5 <210> SEQ ID NO 111 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 111 Gly Gln Gly Tyr Ser Tyr Pro Tyr Thr 1 5
<210> SEQ ID NO 112 <211> LENGTH: 227 <212> TYPE:
PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 112
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 1 5
10 15 Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
Phe 20 25 30 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu 35 40 45 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe 50 55 60 Phe Leu Tyr Ser Lys Leu Thr Val Asp
Lys Ser Arg Trp Gln Gln Gly 65 70 75 80 Asn Val Phe Ser Cys Ser Val
Met His Glu Ala Leu His Asn His Tyr 85 90 95 Thr Gln Lys Ser Leu
Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 100 105 110 Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gln Pro Arg Glu Pro Gln 115 120 125 Val
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 130 135
140 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
145 150 155 160 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
Thr Thr Pro 165 170 175 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
Tyr Ser Lys Leu Thr 180 185 190 Val Asp Lys Ser Arg Trp Gln Gln Gly
Asn Val Phe Ser Cys Ser Val 195 200 205 Met His Glu Ala Leu His Asn
His Tyr Thr Gln Lys Ser Leu Ser Leu 210 215 220 Ser Pro Gly 225
<210> SEQ ID NO 113 <211> LENGTH: 333 <212> TYPE:
DNA <213> ORGANISM: mus musculus <400> SEQUENCE: 113
gacattcagc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc
60 atctcctgca aggccagcca aagtgttgat tatgatggtg atagttattt
gaactggtac 120 caacagatac caggacagcc acccaaactc ctcatctatg
atgcatccaa tctagtatct 180 gggattccac ccaggtttag tggcagtggg
tctgggacag acttcaccct caacatccat 240 cctgtggaga aggtggatgc
tgcaacctat cactgtcagc aaagtactga ggacccttgg 300 acgttcggtg
gaggcaccaa gctggaaatc aaa 333 <210> SEQ ID NO 114 <211>
LENGTH: 111 <212> TYPE: PRT <213> ORGANISM: mus
musculus <400> SEQUENCE: 114 Asp Ile Gln Leu Thr Gln Ser Pro
Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser
Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr
Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu
Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65
70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln
Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
Glu Ile Lys 100 105 110 <210> SEQ ID NO 115 <211>
LENGTH: 372 <212> TYPE: DNA <213> ORGANISM: mus
musculus <400> SEQUENCE: 115 caggttcagc tgcagcagtc tggggctgag
ctggtgcggc ctgggtcctc agtgaagatt 60 tcctgcaaag catctggcta
cgcattcagt agctactgga tgaactgggt gaagcagagg 120 cctggacagg
gtcttgagtg gattggacag atttggcctg gagatggtga tactaactac 180
aacggaaagt tcaagggcaa ggccacactg actgcagacg aatcctccag cacagcctac
240 atgcagctca gcagcctggc ctctgaggac tctgcggtct atttctgtgc
aagacgagaa 300 acgaccactg tcgggcgtta ttactatgct atggactact
ggggtcaagg aaccacagtc 360 accgtctcct ca 372 <210> SEQ ID NO
116 <211> LENGTH: 124 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 116 Gln Val Gln Leu
Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val
Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35
40 45 Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys
Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser
Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser
Ala Val Tyr Phe Cys 85 90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly
Arg Tyr Tyr Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr
Val Thr Val Ser Ser 115 120 <210> SEQ ID NO 117 <211>
LENGTH: 648 <212> TYPE: DNA <213> ORGANISM: homo
sapiens <400> SEQUENCE: 117 gcacctgaac tcctgggggg accgtcagtc
ttcctcttcc ccccaaaacc caaggacacc 60 ctcatgatct cccggacccc
tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac 120 cctgaggtca
agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag 180
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac
240 caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc
cctcccagcc 300 cccatcgaga aaaccatctc caaagccaaa gggcagcccc
gagaaccaca ggtgtacacc 360 aagcccccat cccgggagga gatgaccaag
aaccaggtca gcctgtcctg cctggtcaaa 420 ggcttctatc ccagcgacat
cgccgtggag tgggagagca atgggcagcc ggagaacaac 480 tacaagacca
cggttcccgt gctggactcc gacggctcct tccgcctcgc tagctacctc 540
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag
600 gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggg 648
<210> SEQ ID NO 118 <211> LENGTH: 718 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 118 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val Lys Gln Arg
Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile Trp Pro Gly
Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185 190 Lys Ala
Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205
Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 210
215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr
Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly
Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val Ser His Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310 315 320 Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 325 330
335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg
Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Ser Cys Leu Val
Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr Thr Val Pro
Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala 420 425 430 Ser Tyr Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435 440 445 Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 450 455
460 Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Asp Ile Lys Leu Gln
465 470 475 480 Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val
Lys Met Ser 485 490 495 Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr
Thr Met His Trp Val 500 505 510 Lys Gln Arg Pro Gly Gln Gly Leu Glu
Trp Ile Gly Tyr Ile Asn Pro 515 520 525 Ser Arg Gly Tyr Thr Asn Tyr
Asn Gln Lys Phe Lys Asp Lys Ala Thr 530 535 540 Leu Thr Thr Asp Lys
Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 545 550 555 560 Leu Thr
Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp 565 570 575
Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 580
585 590 Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly
Ser 595 600 605 Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala
Ile Met Ser 610 615 620 Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys
Arg Ala Ser Ser Ser 625 630 635 640 Val Ser Tyr Met Asn Trp Tyr Gln
Gln Lys Ser Gly Thr Ser Pro Lys 645 650 655 Arg Trp Ile Tyr Asp Thr
Ser Lys Val Ala Ser Gly Val Pro Tyr Arg 660 665 670 Phe Ser Gly Ser
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser 675 680 685 Met Glu
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser 690 695 700
Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 705 710 715
<210> SEQ ID NO 119 <211> LENGTH: 249 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 119
Ser Thr Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 1 5
10 15 Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr
Thr 20 25 30 Phe Thr Asp Tyr Val Ile Asn Trp Gly Lys Gln Arg Ser
Gly Gln Gly 35 40 45 Leu Glu Trp Ile Gly Glu Ile Tyr Pro Gly Ser
Gly Thr Asn Tyr Tyr 50 55 60 Asn Glu Lys Phe Lys Ala Lys Ala Thr
Leu Thr Ala Asp Lys Ser Ser 65 70 75 80 Asn Ile Ala Tyr Met Gln Leu
Ser Ser Leu Thr Ser Glu Asp Ser Ala 85 90 95 Val Tyr Phe Cys Ala
Arg Arg Gly Arg Tyr Gly Leu Tyr Ala Met Asp 100 105 110 Tyr Trp Gly
Gln Gly Thr Ser Val Thr Val Ser Ser Val Glu Gly Gly 115 120 125 Ser
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile 130 135
140 Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg
145 150 155 160 Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn
Tyr Leu Asn 165 170 175 Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys
Leu Leu Ile Tyr Tyr 180 185 190 Thr Ser Arg Leu His Ser Gly Val Pro
Ser Arg Phe Ser Gly Ser Gly 195 200 205 Ser Gly Thr Asp Tyr Ser Leu
Thr Ile Asn Asn Leu Glu Gln Glu Asp 210 215 220 Ile Ala Thr Tyr Phe
Cys Gln Gln Gly Asn Thr Arg Pro Trp Thr Phe 225 230 235 240 Gly Gly
Gly Thr Lys Leu Glu Ile Lys 245 <210> SEQ ID NO 120
<211> LENGTH: 251 <212> TYPE: PRT <213> ORGANISM:
mus musculus <400> SEQUENCE: 120 Ser Thr Gly Ser Glu Val Gln
Leu Gln Glu Ser Gly Pro Gly Leu Val 1 5 10 15 Lys Pro Ser Gln Ser
Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser 20 25 30 Ile Thr Ser
Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn 35 40 45 Lys
Leu Glu Trp Met Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr 50 55
60 Asn Pro Ser Leu Glu Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Thr
65 70 75 80 Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp
Thr Ala 85 90 95 Thr Tyr Tyr Cys Ala Arg Gly Gly Tyr Tyr Gly Ser
Ser Trp Gly Val 100 105 110 Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val
Thr Val Ser Ala Val Glu 115 120 125 Gly Gly Ser Gly Gly Ser Gly Gly
Ser Gly Gly Ser Gly Gly Val Asp 130 135 140 Asp Ile Gln Met Thr Gln
Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 145 150 155 160 Glu Thr Val
Thr Ile Thr Cys Arg Val Ser Glu Asn Ile Tyr Ser Tyr 165 170 175 Leu
Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 180 185
190 Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
195 200 205 Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu
Gln Pro 210 215 220 Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr
Gly Thr Pro Trp 225 230 235 240 Thr Phe Gly Gly Gly Thr Lys Leu Glu
Ile Lys 245 250 <210> SEQ ID NO 121 <211> LENGTH: 245
<212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 121 Ser Thr Gly Ser Glu Val Gln Leu Gln Gln
Ser Gly Pro Glu Leu Val 1 5 10 15 Lys Pro Gly Ala Ser Val Lys Ile
Ser Cys Lys Thr Ser Gly Tyr Thr 20 25 30 Phe Thr Glu Tyr Thr Met
His Trp Val Lys Gln Ser His Gly Lys Ser 35 40 45 Leu Glu Trp Ile
Gly Gly Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr 50 55 60 Asn Gln
Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 65 70 75 80
Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 85
90 95 Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser Phe Asp Tyr Trp Gly
Gln 100 105 110 Gly Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser
Gly Gly Ser 115 120 125 Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp
Ile Val Met Thr Gln 130 135 140 Ser Pro Ala Thr Leu Ser Val Thr Pro
Gly Asp Arg Val Ser Leu Ser 145 150 155 160 Cys Arg Ala Ser Gln Ser
Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln 165 170 175 Lys Ser His Glu
Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser 180 185 190 Ile Ser
Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp 195 200 205
Phe Thr Leu Ser Ile Asn Ser Val Glu Pro Glu Asp Val Gly Val Tyr 210
215 220 Tyr Cys Gln Asn Gly His Ser Phe Pro Leu Thr Phe Gly Ala Gly
Thr 225 230 235 240 Lys Leu Glu Leu Lys 245 <210> SEQ ID NO
122 <211> LENGTH: 246 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 122 Ser Thr Gly Ser
Gln Val Gln Leu Gln Gln Ser Ala Val Glu Leu Ala 1 5 10 15 Arg Pro
Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 20 25 30
Phe Thr Ser Phe Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly 35
40 45 Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Glu
Tyr 50 55 60 Asn Gln Lys Phe Lys Asp Lys Thr Thr Leu Thr Ala Asp
Lys Ser Ser 65 70 75 80 Ser Thr Ala Tyr Met Gln Leu Asp Ser Leu Thr
Ser Asp Asp Ser Ala 85 90 95 Val Tyr Tyr Cys Val Arg Gly Ser Ser
Arg Gly Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val
Ser Ala Val Glu Gly Gly Ser Gly Gly 115 120 125 Ser Gly Gly Ser Gly
Gly Ser Gly Gly Val Asp Asp Ile Gln Met Ile 130 135 140 Gln Ser Pro
Ala Ser Leu Ser Val Ser Val Gly Glu Thr Val Thr Ile 145 150 155 160
Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Phe Gln 165
170 175 Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr Ala Ala Thr
Asn 180 185 190 Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
Ser Gly Thr 195 200 205 Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser
Glu Asp Phe Gly Ile 210 215 220 Tyr Tyr Cys Gln His Phe Trp Gly Thr
Pro Arg Thr Phe Gly Gly Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys
245 <210> SEQ ID NO 123 <211> LENGTH: 245 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
123 Ser Thr Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ser Val Leu Val
1 5 10 15 Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly
Tyr Thr 20 25 30 Phe Thr Ser Ser Trp Met His Trp Ala Lys Gln Arg
Pro Gly Gln Gly 35 40 45 Leu Glu Trp Ile Gly His Ile His Pro Asn
Ser Gly Ile Ser Asn Tyr 50 55 60 Asn Glu Lys Phe Lys Gly Lys Ala
Thr Leu Thr Val Asp Thr Ser Ser 65 70 75 80 Ser Thr Ala Tyr Val Asp
Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 85 90 95 Val Tyr Tyr Cys
Ala Arg Gly Gly Arg Phe Asp Asp Trp Gly Ala Gly 100 105 110 Thr Thr
Val Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 115 120 125
Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Val Met Thr Gln Ser 130
135 140 Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser
Cys 145 150 155 160 Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His Trp
Tyr Gln Gln Lys 165 170 175 Ser His Glu Ser Pro Arg Leu Leu Ile Lys
Tyr Ala Ser Gln Ser Ile 180 185 190 Ser Gly Ile Pro Ser Arg Phe Ser
Gly Ser Gly Ser Gly Ser Asp Phe 195 200 205 Thr Leu Ser Ile Asn Ser
Val Glu Pro Glu Asp Val Gly Val Tyr Tyr 210 215 220 Cys Gln Asn Gly
His Ser Phe Leu Met Tyr Thr Phe Gly Gly Gly Thr 225 230 235 240 Lys
Leu Glu Ile Lys 245 <210> SEQ ID NO 124 <211> LENGTH:
249 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 124 Ser Thr Gly Ser Asp Val Gln Leu Gln Glu
Ser Gly Pro Gly Leu Val 1 5 10 15 Lys Pro Ser Gln Ser Leu Ser Leu
Thr Cys Thr Val Thr Gly Tyr Ser 20 25 30 Ile Thr Ser Asp Tyr Ala
Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn 35 40 45 Lys Leu Glu Trp
Met Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Asn Tyr 50 55 60 Asn Pro
Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys 65 70 75 80
Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala 85
90 95 Thr Tyr Tyr Cys Ala Arg Cys Trp Asp Tyr Ala Leu Tyr Ala Met
Asp 100 105 110 Cys Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Val
Glu Gly Gly 115 120 125 Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly
Gly Val Asp Asp Ile 130 135 140 Gln Met Thr Gln Ser Pro Ala Ser Leu
Ser Ala Ser Val Gly Glu Thr 145 150 155 160 Val Thr Ile Thr Cys Arg
Thr Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 165 170 175 Trp Cys Gln Gln
Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr Asn 180 185 190 Ala Lys
Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 195 200 205
Ser Gly Thr His Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro Glu Asp 210
215 220 Phe Gly Ile Tyr Tyr Cys Gln His His Tyr Asp Thr Pro Leu Thr
Phe 225 230 235 240 Gly Ala Gly Thr Lys Leu Glu Leu Lys 245
<210> SEQ ID NO 125 <211> LENGTH: 246 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 125
Ser Thr Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Gln 1 5
10 15 Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Thr 20 25 30 Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro
Gly Lys Gly 35 40 45 Leu Lys Trp Met Gly Trp Ile Asn Thr Asn Thr
Gly Glu Pro Thr Tyr 50 55 60 Ala Glu Glu Phe Lys Gly Arg Phe Ala
Phe Ser Leu Glu Thr Ser Ala 65 70 75 80 Ser Thr Ala Tyr Leu Gln Ile
Asn Asn Leu Lys Asn Glu Asp Thr Ala 85 90 95 Thr Tyr Phe Cys Ala
Arg Asp Tyr Leu Tyr Tyr Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr
Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly 115 120 125 Ser
Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asn Ile Val Met Thr 130 135
140 Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly Glu Arg Val Thr Leu
145 150 155 160 Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr Val Ser
Trp Tyr Gln 165 170 175 Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile
Tyr Gly Ala Ser Asn 180 185 190 Arg Tyr Thr Gly Val Pro Asp Arg Phe
Thr Gly Ser Gly Ser Ala Thr 195 200 205 Asp Phe Thr Leu Thr Ile Ser
Ser Val Gln Ala Glu Asp Leu Ala Asp 210 215 220 Tyr His Cys Gly Gln
Gly Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly 225 230 235 240 Thr Lys
Leu Glu Ile Lys 245 <210> SEQ ID NO 126 <211> LENGTH:
751 <212> TYPE: DNA <213> ORGANISM: mus musculus
<400> SEQUENCE: 126 gtcgactgga agccaggtac agctgcagca
gtctggccct gaactcgtca aaccaggagc 60 ttccgtgaag atgtcctgca
aggcttcagg gtacacgttt accgactatg tgatcaattg 120 gggtaagcag
cgctctgggc aaggcttgga gtggattggc gagatctatc ctgggagtgg 180
gaccaactat tacaacgaga agttcaaggc caaagccact ttgactgcag acaagagctc
240 aaacattgcc tacatgcaac tgagctccct gacatcagag gattctgctg
tgtacttctg 300 tgcacgtaga ggtcggtacg gtctgtatgc catggactat
tggggccaag gcacttccgt 360 gacagtcagc tctgtggaag gaggaagtgg
cggttcagga ggtagcggag ggtccggagg 420 agtggatgac attcagatga
cacagaccac ttctagcctc tccgcatccc ttggggatag 480 ggtcaccatc
agttgtaggg ctagccagga catttccaat tacctgaact ggtatcagca 540
gaaacccgat ggcacagtta agcttctgat ctactacaca agcagactgc actcaggggt
600 tccatctcgg tttagtggaa gtggctctgg taccgactat tccctgacca
tcaacaatct 660 ggaacaggaa gatatcgcca cctacttctg ccaacagggc
aatactcgac cctggacatt 720 tggtggcggc acgaaactcg agataaaata a 751
<210> SEQ ID NO 127 <211> LENGTH: 757 <212> TYPE:
DNA <213> ORGANISM: Mus musculus <400> SEQUENCE: 127
gtcgactgga tccgaggtac agttgcagga gagtgggcct ggactggtca aaccctccca
60 atctctgagc ttgacatgca cagtcacagg ctacagcatc acctccgact
acgcttggaa 120 ttggattcga cagtttcccg gcaacaagct ggaatggatg
ggctacatca cctatagtgg 180 tagcacttcc tataatccct cacttgagag
ccggatttcc atcactaggg atacgagcac 240 caaccagttc ttcctgcagc
tgaatagcgt caccaccgaa gatactgcca cctattactg 300 cgcaagaggc
ggttactatg gcagttcatg gggtgtattc gcctattggg gacaggggac 360
acttgtgaca gtgtctgctg ttgaaggtgg atccggcgga tcaggaggga gtggtggcag
420 tggaggtgtt gacgacattc agatgaccca atcccctgct tctctctcag
cctctgtggg 480 agagactgtg accataacct gtcgtgttag cgagaacatc
tactcctatc tcgcctggta 540 tcagcagaaa caggggaaat ccccacaact
gctcgtgtac aatgccaaga ctctggcaga 600 aggagtgcca agccgctttt
ccgggtctgg gtctgggaca cagttctcac tgaagatcaa 660 ctctttgcaa
cctgaggatt ttggctctta ctactgtcag catcactatg gcacaccatg 720
gacgtttggt ggcggcacta agctggagat taagtaa 757 <210> SEQ ID NO
128 <211> LENGTH: 739 <212> TYPE: DNA <213>
ORGANISM: Mus musculus <400> SEQUENCE: 128 gtcgactggg
tccgaagtgc aactgcaaca gtctggccct gagctggtca aacccggtgc 60
ttcagtgaag atctcctgca agacatccgg ctacaccttc actgagtaca ccatgcactg
120 ggtcaaacag tctcacggta agagcctgga gtggataggc ggaatttcac
ccaacattgg 180 agggacctcc tataaccaga agttcaaggg caaagccacc
cttacagttg acaagagcag 240 ttcaactgcc tacatggaac tgcgctcatt
gacctccgag gattcagccg tgtattactg 300 cgctagaagg ggaggatcct
tcgattattg gggccaaggc actacgctta ccgtgagcag 360 cgttgaaggt
ggttctggcg gctctggtgg aagtggaggg agtggcgggg tagacgacat 420
cgtgatgact cagagtccag caactctgtc cgttacacct ggagatcgag tgtctctgag
480 ttgtcgtgca agccagtcta tctctgacta tctgcactgg tatcagcaga
agagccatga 540 gtcacctagg ctgttgatca agtacgcctc tcagtccatt
agcgggattc catcccggtt 600 tagtggctct ggctccggta gtgacttcac
actcagcatc aatagcgtcg aaccagagga 660 tgtaggggtg tactactgtc
agaatgggca ttcctttccc ctcacatttg gagctggtac 720 caaactcgag
ctgaaataa 739 <210> SEQ ID NO 129 <211> LENGTH: 742
<212> TYPE: DNA <213> ORGANISM: Mus musculus
<400> SEQUENCE: 129 gtcgactggc tcccaagtac agcttcagca
gtctgccgtc gaacttgctc gaccaggagc 60 ttcagtgaag atgagctgca
aagcctctgg ttacaccttc acgtccttta ccatgcattg 120 ggtgaagcag
cgtcctggcc aaggcctgga gtggattggc tacatcaatc cctccagcgg 180
gtataccgag tacaaccaga agttcaagga caaaacaacc ctgactgccg ataagtcaag
240 tagcacagcc tatatgcagc tggattccct gacatcagac gatagcgctg
tgtattactg 300 cgttaggggc tctagcagag ggttcgacta ttggggtcaa
ggcacactgg tcacggttag 360 tgccgttgaa ggaggctctg gaggcagtgg
aggttctgga gggtcaggcg gtgtggatga 420 cattcagatg attcagagtc
ccgctagctt gagtgtaagc gtcggtgaga cagtgaccat 480 cacttgtcgc
gcatccgaaa acatctactc caatctcgca tggttccagc agaaacaggg 540
caaatcaccc caattgctcg tgtatgccgc aactaatctg gctgatggtg tgccttccag
600 gtttagcggg tctggatctg ggactcagta ctccctgaag atcaactccc
tccagtctga 660 ggacttcggg atctattact gtcagcactt ttggggaact
ccacggacct ttggaggcgg 720 gaccaaactg gagataaagt aa 742 <210>
SEQ ID NO 130 <211> LENGTH: 696 <212> TYPE: DNA
<213> ORGANISM: Mus musculus <400> SEQUENCE: 130
ctggtgaggc caggtgcatc tgtgaagctg tcatgcaaag catccgggta cacgttcacc
60 tcttcatgga tgcattgggc caaacagcgt ccaggccagg gccttgagtg
gattggacac 120 attcacccca atagcggcat atccaactac aacgagaagt
tcaagggcaa agccacactg 180 acagtggata cttccagctc tacagcctat
gtggacctta gtagcttgac cagtgaggat 240 tctgccgtat actactgtgc
tagaggtggg cggtttgacg attggggtgc tgggaccaca 300 gtcaccgtga
gcagtgtcga aggtggatca ggtggatctg gaggctcagg cggttctggc 360
ggtgttgacg acatcgtgat gactcaaagc cctgctactc tctctgtcac acccggagat
420 agggtaagcc tcagttgtcg agcaagccag tcaatcagcg actatctgca
ctggtatcag 480 cagaagtccc atgaatcccc acgcttgctc atcaagtacg
ccagtcagtc catcagtggc 540 attccttccc ggttttctgg gtctggatcc
gggtcagact tcactctgag cattaactcc 600 gtcgaacccg aggatgttgg
cgtgtattat tgccagaatg gacattcctt cctgatgtac 660 acctttggcg
gagggaccaa actggagatc aagtaa 696 <210> SEQ ID NO 131
<211> LENGTH: 751 <212> TYPE: DNA <213> ORGANISM:
Mus musculus <400> SEQUENCE: 131 gtcgactggg tctgatgtgc
agttgcagga gtcaggacct gggcttgtca agccaagcca 60 gagcctcagt
ctcacttgca ctgtcacagg ctatagcatc acatccgact atgcttggaa 120
ttggattagg cagtttcctg gcaataagct ggaatggatg gggtacatca cctattccgg
180 cagtaccaac tacaatccca gcttgaaatc tcggatttcc ataacacgcg
atactagcaa 240 gaaccagttc ttccttcagc tgaactctgt gacaacagag
gataccgcta cgtactattg 300 cgccagatgc tgggattacg ccctgtatgc
catggactgt tggggtcaag gtaccagcgt 360 tactgtgtct agcgtcgaag
gcggaagtgg cggctcagga gggtcaggag gctcaggcgg 420 agtggatgac
attcagatga cccaatctcc cgcatccctg tccgcatcag taggggagac 480
agtgaccatt acctgtcgta cttccgagaa catctactcc tatcttgcct ggtgtcaaca
540 gaaacagggg aaaagtccac agctgctggt gtataacgcc aagaccttgg
cagaaggtgt 600 tcccagtcga ttctctggtt ccggatccgg tacacacttc
agcctgaaga tcaattctct 660 gcaaccagag gactttggaa tctactactg
ccagcatcac tacgacactc ctctgacgtt 720 tggcgctggt accaagctcg
aactgaaata a 751 <210> SEQ ID NO 132 <211> LENGTH: 742
<212> TYPE: DNA <213> ORGANISM: Mus musculus
<400> SEQUENCE: 132 gtcgactggt agccagatac agctggtaca
gtcaggacca gagctgcaga aacctggaga 60 gacagtgaag atcagctgca
aggctagcgg gtacaccttc acgaattacg ggatgaactg 120 ggtcaagcag
gctccaggca aagggctgaa gtggatgggc tggattaaca ccaatactgg 180
ggaaccaacc tatgccgagg aattcaaggg gagatttgcc ttttccctcg aaaccagcgc
240 ctcaaccgcc tatctccaga tcaacaacct gaagaatgag gataccgcta
cctacttctg 300 tgcaagggac tacctctact acttcgacta ttggggccaa
ggtacgactc ttacagtctc 360 tagtgttgag ggagggagtg gaggttctgg
aggctctggt ggctctggag gcgttgacaa 420 catcgtgatg actcagtctc
ccaaaagcat gagtatgagt gtgggtgaac gagttacctt 480 gacatgcaaa
gcctccgaga atgtcgtgac atacgtgtcc tggtatcagc agaaacccga 540
gcaatcccct aagctgctga tctatggcgc tagcaatcgc tatactggcg tacctgatcg
600 gttcacagga tcaggctcag ccactgactt tactcttacc atttcctccg
tgcaggcaga 660 agatttggca gattaccact gtgggcaagg ttactcttat
ccctatacat ttggaggcgg 720 cacaaagctg gagattaagt aa 742 <210>
SEQ ID NO 133 <211> LENGTH: 720 <212> TYPE: PRT
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 133 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val
Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln
Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln
Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala
Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu
Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu
Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 100 105
110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val
115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser
Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser
Ser Tyr Trp Met 145 150 155 160 Asn Trp Val Lys Gln Arg Pro Gly Gln
Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile Trp Pro Gly Asp Gly Asp
Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185 190 Lys Ala Thr Leu Thr
Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205 Leu Ser Ser
Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 210 215 220 Arg
Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp 225 230
235 240 Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Ser Ser
Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val 275 280 285 Val Asp Val Ser His Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp Gly Val Glu Val His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310 315 320 Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 325 330 335 Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 340 345 350
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 355
360 365 Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Glu Glu Met
Thr 370 375 380 Lys Asn Gln Val Ser Leu Ser Cys Leu Val Lys Gly Phe
Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr Thr Val Pro Val Leu Asp
Ser Asp Gly Ser Phe Arg Leu Ala 420 425 430 Ser Tyr Leu Thr Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435 440 445 Ser Cys Ser Val
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 450 455 460 Ser Leu
Ser Leu Ser Pro Gly Ser Thr Gly Ser Gln Val Gln Leu Gln 465 470 475
480 Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser
485 490 495 Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Val Ile Asn
Trp Gly 500 505 510 Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile Gly
Glu Ile Tyr Pro 515 520 525 Gly Ser Gly Thr Asn Tyr Tyr Asn Glu Lys
Phe Lys Ala Lys Ala Thr 530 535 540 Leu Thr Ala Asp Lys Ser Ser Asn
Ile Ala Tyr Met Gln Leu Ser Ser 545 550 555 560 Leu Thr Ser Glu Asp
Ser Ala Val Tyr Phe Cys Ala Arg Arg Gly Arg 565 570 575 Tyr Gly Leu
Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 580 585 590 Val
Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 595 600
605 Ser Gly Gly Val Asp Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
610 615 620 Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala
Ser Gln 625 630 635 640 Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln
Lys Pro Asp Gly Thr 645 650 655 Val Lys Leu Leu Ile Tyr Tyr Thr Ser
Arg Leu His Ser Gly Val Pro 660 665 670 Ser Arg Phe Ser Gly Ser Gly
Ser Gly Thr Asp Tyr Ser Leu Thr Ile 675 680 685 Asn Asn Leu Glu Gln
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 690 695 700 Asn Thr Arg
Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 705 710 715 720
<210> SEQ ID NO 134 <211> LENGTH: 722 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 134 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val Lys Gln Arg
Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile Trp Pro Gly
Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185 190 Lys Ala
Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205
Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 210
215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr
Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly
Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val Ser His Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310 315 320 Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 325 330
335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg
Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Ser Cys Leu Val
Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr Thr Val Pro
Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala 420 425 430 Ser Tyr Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435 440 445 Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 450 455
460 Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Glu Val Gln Leu Gln
465 470 475 480 Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser Leu
Ser Leu Thr 485 490 495 Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp
Tyr Ala Trp Asn Trp 500 505 510 Ile Arg Gln Phe Pro Gly Asn Lys Leu
Glu Trp Met Gly Tyr Ile Thr 515 520 525 Tyr Ser Gly Ser Thr Ser Tyr
Asn Pro Ser Leu Glu Ser Arg Ile Ser 530 535 540 Ile Thr Arg Asp Thr
Ser Thr Asn Gln Phe Phe Leu Gln Leu Asn Ser 545 550 555 560 Val Thr
Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Gly Gly Tyr 565 570 575
Tyr Gly Ser Ser Trp Gly Val Phe Ala Tyr Trp Gly Gln Gly Thr Leu 580
585 590 Val Thr Val Ser Ala Val Glu Gly Gly Ser Gly Gly Ser Gly Gly
Ser 595 600 605 Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Met Thr Gln
Ser Pro Ala 610 615 620 Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr
Ile Thr Cys Arg Val 625 630 635 640 Ser Glu Asn Ile Tyr Ser Tyr Leu
Ala Trp Tyr Gln Gln Lys Gln Gly 645 650 655 Lys Ser Pro Gln Leu Leu
Val Tyr Asn Ala Lys Thr Leu Ala Glu Gly 660 665 670 Val Pro Ser Arg
Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu 675 680 685 Lys Ile
Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 690 695 700
His His Tyr Gly Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 705
710 715 720 Ile Lys <210> SEQ ID NO 135 <211> LENGTH:
716 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 135 Asp Ile Gln Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala
Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly
Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40
45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro
50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn
Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys
Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly
Ala Glu Leu Val Arg Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys
Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn
Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170
175 Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly
180 185 190 Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr
Met Gln 195 200 205 Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr
Phe Cys Ala Arg 210 215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr
Tyr Ala Met Asp Tyr Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr
Val Ser Ser Gly Gly Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295
300 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
305 310 315 320 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
Leu His Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr
Lys Pro Pro Ser Arg Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser
Leu Ser Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415
Lys Thr Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala 420
425 430 Ser Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe 435 440 445 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr Gln Lys 450 455 460 Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser
Glu Val Gln Leu Gln 465 470 475 480 Gln Ser Gly Pro Glu Leu Val Lys
Pro Gly Ala Ser Val Lys Ile Ser 485 490 495 Cys Lys Thr Ser Gly Tyr
Thr Phe Thr Glu Tyr Thr Met His Trp Val 500 505 510 Lys Gln Ser His
Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro 515 520 525 Asn Ile
Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 530 535 540
Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 545
550 555 560 Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg
Gly Gly 565 570 575 Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr
Val Ser Ser Val 580 585 590 Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser
Gly Gly Ser Gly Gly Val 595 600 605 Asp Asp Ile Val Met Thr Gln Ser
Pro Ala Thr Leu Ser Val Thr Pro 610 615 620 Gly Asp Arg Val Ser Leu
Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp 625 630 635 640 Tyr Leu His
Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu 645 650 655 Ile
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser 660 665
670 Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu
675 680 685 Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser
Phe Pro 690 695 700 Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
705 710 715 <210> SEQ ID NO 136 <211> LENGTH: 717
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 136 Asp Ile Gln Leu Thr Gln Ser Pro
Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser
Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr
Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu
Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65
70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln
Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val
Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile
Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185
190 Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln
195 200 205 Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys
Ala Arg 210 215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala
Met Asp Tyr Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser
Ser Gly Gly Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310
315 320 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Lys Pro
Pro Ser Arg Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Ser
Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr
Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala 420 425 430
Ser Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435
440 445 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
Lys 450 455 460 Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Gln Val
Gln Leu Gln 465 470 475 480 Gln Ser Ala Val Glu Leu Ala Arg Pro Gly
Ala Ser Val Lys Met Ser 485 490 495 Cys Lys Ala Ser Gly Tyr Thr Phe
Thr Ser Phe Thr Met His Trp Val 500 505 510 Lys Gln Arg Pro Gly Gln
Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro 515 520 525 Ser Ser Gly Tyr
Thr Glu Tyr Asn Gln Lys Phe Lys Asp Lys Thr Thr 530 535 540 Leu Thr
Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Asp Ser 545 550 555
560 Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Val Arg Gly Ser Ser
565 570 575 Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
Ser Ala 580 585 590 Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly
Gly Ser Gly Gly 595 600 605 Val Asp Asp Ile Gln Met Ile Gln Ser Pro
Ala Ser Leu Ser Val Ser 610 615 620 Val Gly Glu Thr Val Thr Ile Thr
Cys Arg Ala Ser Glu Asn Ile Tyr 625 630 635 640 Ser Asn Leu Ala Trp
Phe Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu 645 650 655 Leu Val Tyr
Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe 660 665 670 Ser
Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu 675 680
685 Gln Ser Glu Asp Phe Gly Ile Tyr Tyr Cys Gln His Phe Trp Gly Thr
690 695 700 Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 705
710 715 <210> SEQ ID NO 137 <211> LENGTH: 716
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 137 Asp Ile Gln Leu Thr Gln Ser Pro
Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser
Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr
Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu
Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65
70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln
Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val
Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile
Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185
190 Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln
195 200 205 Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys
Ala Arg 210 215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala
Met Asp Tyr Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser
Ser Gly Gly Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310
315 320 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Lys Pro
Pro Ser Arg Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Ser
Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr
Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala 420 425 430
Ser Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435
440 445 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
Lys 450 455 460 Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Gln Val
Gln Leu Gln 465 470 475 480 Gln Pro Gly Ser Val Leu Val Arg Pro Gly
Ala Ser Val Lys Leu Ser 485 490 495 Cys Lys Ala Ser Gly Tyr Thr Phe
Thr Ser Ser Trp Met His Trp Ala 500 505 510 Lys Gln Arg Pro Gly Gln
Gly Leu Glu Trp Ile Gly His Ile His Pro 515 520 525 Asn Ser Gly Ile
Ser Asn Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr 530 535 540 Leu Thr
Val Asp Thr Ser Ser Ser Thr Ala Tyr Val Asp Leu Ser Ser 545 550 555
560 Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg
565 570 575 Phe Asp Asp Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
Val Glu 580 585 590 Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser
Gly Gly Val Asp 595 600 605 Asp Ile Val Met Thr Gln Ser Pro Ala Thr
Leu Ser Val Thr Pro Gly 610 615 620 Asp Arg Val Ser Leu Ser Cys Arg
Ala Ser Gln Ser Ile Ser Asp Tyr 625 630 635 640 Leu His Trp Tyr Gln
Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 645 650 655 Lys Tyr Ala
Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 660 665 670 Ser
Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 675 680
685 Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Leu Met
690 695 700 Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 705 710
715 <210> SEQ ID NO 138 <211> LENGTH: 720 <212>
TYPE: PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 138 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val Lys Gln Arg
Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile Trp Pro Gly
Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185 190 Lys Ala
Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205
Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 210
215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr
Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly
Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val Ser His Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310 315 320 Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 325 330
335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg
Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Ser Cys Leu Val
Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr Thr Val Pro
Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala 420 425 430 Ser Tyr Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435 440 445 Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 450 455
460 Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Asp Val Gln Leu Gln
465 470 475 480 Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser Leu
Ser Leu Thr 485 490 495 Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp
Tyr Ala Trp Asn Trp 500 505 510 Ile Arg Gln Phe Pro Gly Asn Lys Leu
Glu Trp Met Gly Tyr Ile Thr 515 520 525 Tyr Ser Gly Ser Thr Asn Tyr
Asn Pro Ser Leu Lys Ser Arg Ile Ser 530 535 540 Ile Thr Arg Asp Thr
Ser Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser 545 550 555 560 Val Thr
Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Cys Trp Asp 565 570 575
Tyr Ala Leu Tyr Ala Met Asp Cys Trp Gly Gln Gly Thr Ser Val Thr 580
585 590 Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly
Gly 595 600 605 Ser Gly Gly Val Asp Asp Ile Gln Met Thr Gln Ser Pro
Ala Ser Leu 610 615 620 Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr
Cys Arg Thr Ser Glu 625 630 635 640 Asn Ile Tyr Ser Tyr Leu Ala Trp
Cys Gln Gln Lys Gln Gly Lys Ser 645 650 655 Pro Gln Leu Leu Val Tyr
Asn Ala Lys Thr Leu Ala Glu Gly Val Pro 660 665 670 Ser Arg Phe Ser
Gly Ser Gly Ser Gly Thr His Phe Ser Leu Lys Ile 675 680 685 Asn Ser
Leu Gln Pro Glu Asp Phe Gly Ile Tyr Tyr Cys Gln His His 690 695 700
Tyr Asp Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 705
710 715 720 <210> SEQ ID NO 139 <211> LENGTH: 717
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 139 Asp Ile Gln Leu Thr Gln Ser Pro
Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser
Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr
Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu
Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65
70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln
Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val
Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile
Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185
190 Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln
195 200 205 Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys
Ala Arg 210 215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala
Met Asp Tyr Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser
Ser Gly Gly Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310
315 320 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Lys Pro
Pro Ser Arg Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Ser
Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr
Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala 420 425 430
Ser Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435
440 445 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
Lys 450 455 460 Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Gln Ile
Gln Leu Val 465 470 475 480 Gln Ser Gly Pro Glu Leu Gln Lys Pro Gly
Glu Thr Val Lys Ile Ser 485 490 495 Cys Lys Ala Ser Gly Tyr Thr Phe
Thr Asn Tyr Gly Met Asn Trp Val 500 505 510 Lys Gln Ala Pro Gly Lys
Gly Leu Lys Trp Met Gly Trp Ile Asn Thr 515 520 525 Asn Thr Gly Glu
Pro Thr Tyr Ala Glu Glu Phe Lys Gly Arg Phe Ala 530 535 540 Phe Ser
Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn 545 550 555
560 Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Tyr Leu
565 570 575 Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
Ser Ser 580 585 590 Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly
Gly Ser Gly Gly 595 600 605 Val Asp Asn Ile Val Met Thr Gln Ser Pro
Lys Ser Met Ser Met Ser 610 615 620 Val Gly Glu Arg Val Thr Leu Thr
Cys Lys Ala Ser Glu Asn Val Val 625 630 635 640 Thr Tyr Val Ser Trp
Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu 645 650 655 Leu Ile Tyr
Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe 660 665 670 Thr
Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 675 680
685 Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr
690 695 700 Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 705
710 715 <210> SEQ ID NO 140 <211> LENGTH: 698
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 140 Asp Ile Gln Leu Thr Gln Ser Pro
Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser
Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr
Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu
Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65
70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln
Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val
Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile
Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185
190 Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln
195 200 205 Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys
Ala Arg 210 215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala
Met Asp Tyr Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser
Ser Gly Gly Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310
315 320 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Lys Pro
Pro Ser Arg Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Ser
Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr
Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala 420 425 430
Ser Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435
440 445 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
Lys 450 455 460 Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Glu Val
Gln Leu Gln 465 470 475 480 Gln Ser Gly Pro Glu Leu Val Lys Pro Gly
Ala Ser Val Lys Ile Ser 485 490 495 Cys Lys Thr Ser Gly Tyr Thr Phe
Thr Glu Tyr Thr Met His Trp Val 500 505 510 Lys Gln Ser His Gly Lys
Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro 515 520 525 Asn Ile Gly Gly
Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 530 535 540 Leu Thr
Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 545 550 555
560 Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Gly Gly
565 570 575 Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser
Ser Ala 580 585 590 Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Ser Ser Lys Ser 595 600 605 Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe 610 615 620 Pro Glu Pro Val Thr Val Ser Trp
Asn Ser Gly Ala Leu Thr Ser Gly 625 630 635 640 Val His Thr Phe Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 645 650 655 Ser Ser Val
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 660 665 670 Ile
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 675 680
685 Val Glu Pro Lys Ser Cys Asp Lys Thr His 690 695 <210> SEQ
ID NO 141 <211> LENGTH: 214 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 141 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val
Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln
Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr Gln Gln Lys Ser His
Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Gln Ser Ile
Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ser
Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 65 70 75 80 Glu Asp Val
Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 85 90 95 Thr
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 100 105
110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys
Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys
Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr
His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg
Gly Glu Cys 210 <210> SEQ ID NO 142 <211> LENGTH: 837
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 142 Asp Ile Gln Leu Thr Gln Ser Pro
Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser
Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr
Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu
Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65
70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln
Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val
Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile
Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185
190 Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln
195 200 205 Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys
Ala Arg 210 215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala
Met Asp Tyr Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser
Ser Gly Gly Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310
315 320 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Leu Pro
Pro Ser Arg Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Thr
Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 420 425 430
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435
440 445 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
Lys 450 455 460 Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly
Gly Gly Gly 465 470 475 480 Ser Gly Gly Gly Gly Ser Gly Gln Pro Arg
Glu Pro Gln Val Tyr Thr 485 490 495 Leu Pro Pro Ser Arg Glu Glu Met
Thr Lys Asn Gln Val Ser Leu Thr 500 505 510 Cys Leu Val Lys Gly Phe
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 515 520 525 Ser Asn Gly Gln
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 530 535 540 Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 545 550 555
560 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
565 570 575 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly 580 585 590 Ser Thr Gly Ser Glu Val Gln Leu Gln Gln Ser Gly
Pro Glu Leu Val 595 600 605 Lys Pro Gly Ala Ser Val Lys Ile Ser Cys
Lys Thr Ser Gly Tyr Thr 610 615 620 Phe Thr Glu Tyr Thr Met His Trp
Val Lys Gln Ser His Gly Lys Ser 625 630 635 640 Leu Glu Trp Ile Gly
Gly Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr 645 650 655 Asn Gln Lys
Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 660 665 670 Ser
Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 675 680
685 Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln
690 695 700 Gly Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly
Gly Ser 705 710 715 720 Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp
Ile Val Met Thr Gln 725 730 735 Ser Pro Ala Thr Leu Ser Val Thr Pro
Gly Asp Arg Val Ser Leu Ser 740 745 750 Cys Arg Ala Ser Gln Ser Ile
Ser Asp Tyr Leu His Trp Tyr Gln Gln 755 760 765 Lys Ser His Glu Ser
Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser 770 775 780 Ile Ser Gly
Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp 785 790 795 800
Phe Thr Leu Ser Ile Asn Ser Val Glu Pro Glu Asp Val Gly Val Tyr 805
810 815 Tyr Cys Gln Asn Gly His Ser Phe Pro Leu Thr Phe Gly Ala Gly
Thr 820 825 830 Lys Leu Glu Leu Lys 835 <210> SEQ ID NO 143
<211> LENGTH: 837 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 143 Asp
Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10
15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp
20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln
Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser
Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala
Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe
Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu
Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val 130 135 140
Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 145
150 155 160 Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
Gly Gln 165 170 175 Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly
Lys Phe Lys Gly 180 185 190 Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser
Ser Thr Ala Tyr Met Gln 195 200 205 Leu Ser Ser Leu Ala Ser Glu Asp
Ser Ala Val Tyr Phe Cys Ala Arg 210 215 220 Arg Glu Thr Thr Thr Val
Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp 225 230 235 240 Gly Gln Gly
Thr Thr Val Thr Val Ser Ser Gly Gly Gly Ser Ser Ala 245 250 255 Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265
270 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
275 280 285 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
Tyr Val 290 295 300 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
Arg Glu Glu Gln 305 310 315 320 Tyr Ser Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu His Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val Ser Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 370 375 380 Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390
395 400 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
Tyr 405 410 415 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
Phe Leu Tyr 420 425 430 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln Gly Asn Val Phe 435 440 445 Ser Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr Thr Gln Lys 450 455 460 Ser Leu Ser Leu Ser Pro Gly
Gly Gly Gly Gly Ser Gly Gly Gly Gly 465 470 475 480 Ser Gly Gly Gly
Gly Ser Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 485 490 495 Leu Pro
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 500 505 510
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 515
520 525 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
Leu 530 535 540 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
Val Asp Lys 545 550 555 560 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
Cys Ser Val Met His Glu 565 570 575 Ala Leu His Asn His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly 580 585 590 Ser Thr Gly Ser Glu Val
Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 595 600 605 Lys Pro Gly Ala
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr 610 615 620 Phe Thr
Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser 625 630 635
640 Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr
645 650 655 Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys
Ser Ser 660 665 670 Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser
Glu Asp Ser Ala 675 680 685 Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser
Phe Asp Tyr Trp Gly Gln 690 695 700 Gly Thr Thr Leu Thr Val Ser Ser
Val Glu Gly Gly Ser Gly Gly Ser 705 710 715 720 Gly Gly Ser Gly Gly
Ser Gly Gly Val Asp Asp Ile Val Met Thr Gln 725 730 735 Ser Pro Ala
Thr Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser 740 745 750 Cys
Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln 755 760
765 Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser
770 775 780 Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
Ser Asp 785 790 795 800 Phe Thr Leu Ser Ile Asn Ser Val Glu Pro Glu
Asp Val Gly Val Tyr 805 810 815 Tyr Cys Gln Asn Gly His Ser Phe Pro
Leu Thr Phe Gly Ala Gly Thr 820 825 830 Lys Leu Glu Leu Lys 835
<210> SEQ ID NO 144 <211> LENGTH: 218 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 144 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys
Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> SEQ ID
NO 145 <211> LENGTH: 675 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 145 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys Gln Arg Pro
Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp Pro Gly Asp
Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly Lys Ala Thr
Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu
Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala
Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 100 105
110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys
115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys
Ser Cys Gly Gly Gly Ser Ser Ala Pro Glu Leu Leu Gly Gly Pro 225 230
235 240 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
Ser 245 250 255 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
His Glu Asp 260 265 270 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
Val Glu Val His Asn 275 280 285 Ala Lys Thr Lys Pro Arg Glu Glu Gln
Tyr Ser Ser Thr Tyr Arg Val 290 295 300 Val Ser Val Leu Thr Val Leu
His Gln Asp Trp Leu Asn Gly Lys Glu 305 310 315 320 Tyr Lys Cys Lys
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 325 330 335 Thr Ile
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 340 345 350
Lys Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 355
360 365 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
Glu 370 375 380 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Val
Pro Val Leu 385 390 395 400 Asp Ser Asp Gly Ser Phe Arg Leu Ala Ser
Tyr Leu Thr Val Asp Lys 405 410 415 Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser Cys Ser Val Met His Glu 420 425 430 Ala Leu His Asn His Tyr
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 Ser Thr Gly Ser
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 450 455 460 Lys Pro
Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr 465 470 475
480 Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser
485 490 495 Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn Ile Gly Gly Thr
Ser Tyr 500 505 510 Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val
Asp Lys Ser Ser 515 520 525 Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu
Thr Ser Glu Asp Ser Ala 530 535 540 Val Tyr Tyr Cys Ala Arg Arg Gly
Gly Ser Phe Asp Tyr Trp Gly Gln 545 550 555 560 Gly Thr Thr Leu Thr
Val Ser Ser Arg Thr Val Ala Ala Pro Ser Val 565 570 575 Phe Ile Phe
Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 580 585 590 Val
Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 595 600
605 Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val
610 615 620 Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
Thr Leu 625 630 635 640 Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
Val Tyr Ala Cys Glu 645 650 655 Val Thr His Gln Gly Leu Ser Ser Pro
Val Thr Lys Ser Phe Asn Arg 660 665 670 Gly Glu Cys 675 <210>
SEQ ID NO 146 <211> LENGTH: 214 <212> TYPE: PRT
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 146 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val
Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln
Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr Gln Gln Lys Ser His
Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Gln Ser Ile
Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ser
Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 65 70 75 80 Glu Asp Val
Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 85 90 95 Thr
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala Ser Thr Lys Gly 100 105
110 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
115 120 125 Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
Pro Val 130 135 140 Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
Val His Thr Phe 145 150 155 160 Pro Ala Val Leu Gln Ser Ser Gly Leu
Tyr Ser Leu Ser Ser Val Val 165 170 175 Thr Val Pro Ser Ser Ser Leu
Gly Thr Gln Thr Tyr Ile Cys Asn Val 180 185 190 Asn His Lys Pro Ser
Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 195 200 205 Ser Cys Asp
Lys Thr His 210 <210> SEQ ID NO 147 <211> LENGTH: 218
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 147 Asp Ile Gln Leu Thr Gln Ser Pro
Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser
Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr
Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu
Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65
70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln
Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe
Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val
Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185
190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215
<210> SEQ ID NO 148 <211> LENGTH: 801 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 148 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp
Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85
90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210
215 220 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330
335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser
Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 450 455
460 Gly Gly Gly Ser Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
465 470 475 480 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu 485 490 495 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn 500 505 510 Gly Gln Pro Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser 515 520 525 Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg 530 535 540 Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala Leu 545 550 555 560 His Asn
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Thr 565 570 575
Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 580
585 590 Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe
Thr 595 600 605 Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly Lys
Ser Leu Glu 610 615 620 Trp Ile Gly Gly Ile Ser Pro Asn Ile Gly Gly
Thr Ser Tyr Asn Gln 625 630 635 640 Lys Phe Lys Gly Lys Ala Thr Leu
Thr Val Asp Lys Ser Ser Ser Thr 645 650 655 Ala Tyr Met Glu Leu Arg
Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 660 665 670 Tyr Cys Ala Arg
Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 675 680 685 Thr Leu
Thr Val Ser Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile 690 695 700
Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 705
710 715 720 Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln
Trp Lys 725 730 735 Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
Ser Val Thr Glu 740 745 750 Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
Ser Ser Thr Leu Thr Leu 755 760 765 Ser Lys Ala Asp Tyr Glu Lys His
Lys Val Tyr Ala Cys Glu Val Thr 770 775 780 His Gln Gly Leu Ser Ser
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 785 790 795 800 Cys
<210> SEQ ID NO 149 <211> LENGTH: 214 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 149 Asp Ile Val Met Thr Gln Ser Pro Ala Thr
Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser Cys Arg
Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr Gln Gln
Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser
Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly
Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 65 70 75 80
Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 85
90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala Ser Thr Lys
Gly 100 105 110 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
Ser Gly Gly 115 120 125 Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro Glu Pro Val 130 135 140 Thr Val Ser Trp Asn Ser Gly Ala Leu
Thr Ser Gly Val His Thr Phe 145 150 155 160 Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 165 170 175 Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 180 185 190 Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 195 200 205
Ser Cys Asp Lys Thr His 210 <210> SEQ ID NO 150 <211>
LENGTH: 218 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 150 Asp Ile Gln Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala
Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly
Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40
45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro
50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn
Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys
Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe
Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170
175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215
<210> SEQ ID NO 151 <211> LENGTH: 801 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 151 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp
Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85
90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210
215 220 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330
335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser
Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 450 455
460 Gly Gly Gly Ser Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
465 470 475 480 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu 485 490 495 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn 500 505 510 Gly Gln Pro Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser 515 520 525 Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg 530 535 540 Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala Leu 545 550 555 560 His Asn
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Thr 565 570 575
Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 580
585 590 Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe
Thr 595 600 605 Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly Lys
Ser Leu Glu 610 615 620 Trp Ile Gly Gly Ile Ser Pro Asn Ile Gly Gly
Thr Ser Tyr Asn Gln 625 630 635 640 Lys Phe Lys Gly Lys Ala Thr Leu
Thr Val Asp Lys Ser Ser Ser Thr 645 650 655 Ala Tyr Met Glu Leu Arg
Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 660 665 670 Tyr Cys Ala Arg
Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 675 680 685 Thr Leu
Thr Val Ser Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile 690 695 700
Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 705
710 715 720 Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln
Trp Lys 725 730 735 Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
Ser Val Thr Glu 740 745 750 Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
Ser Ser Thr Leu Thr Leu 755 760 765 Ser Lys Ala Asp Tyr Glu Lys His
Lys Val Tyr Ala Cys Glu Val Thr 770 775 780 His Gln Gly Leu Ser Ser
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 785 790 795 800 Cys
<210> SEQ ID NO 152 <211> LENGTH: 214 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 152 Asp Ile Val Met Thr Gln Ser Pro Ala Thr
Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser Cys Arg
Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr Gln Gln
Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser
Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly
Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 65 70 75 80
Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 85
90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala Ser Thr Lys
Gly 100 105 110 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
Ser Gly Gly 115 120 125 Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro Glu Pro Val 130 135 140 Thr Val Ser Trp Asn Ser Gly Ala Leu
Thr Ser Gly Val His Thr Phe 145 150 155 160 Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 165 170 175 Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 180 185 190 Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 195 200 205
Ser Cys Asp Lys Thr His 210 <210> SEQ ID NO 153 <211>
LENGTH: 218 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 153 Asp Ile Gln Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala
Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly
Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40
45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro
50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn
Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys
Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe
Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170
175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215
<210> SEQ ID NO 154 <211> LENGTH: 796 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 154 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp
Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85
90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210
215 220 Lys Ser Cys Gly Gly Gly Ser Ser Ala Pro Glu Leu Leu Gly Gly
Pro 225 230 235 240 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser 245 250 255 Arg Thr Pro Glu Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp 260 265 270 Pro Glu Val Lys Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn 275 280 285 Ala Lys Thr Lys Pro Arg
Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val 290 295 300 Val Ser Val Leu
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 305 310 315 320 Tyr
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 325 330
335 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
340 345 350 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
Leu Thr 355 360 365 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu 370 375 380 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
Thr Thr Pro Pro Val Leu 385 390 395 400 Asp Ser Asp Gly Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys 405 410 415 Ser Arg Trp Gln Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu 420 425 430 Ala Leu His
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 450 455
460 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
465 470 475 480 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr 485 490 495 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
Gly Gln Pro Glu Asn 500 505 510 Asn Tyr Lys Thr Thr Pro Pro Val Leu
Asp Ser Asp Gly Ser Phe Phe 515 520 525 Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly Asn 530 535 540 Val Phe Ser Cys Ser
Val Met His Glu Ala Leu His Asn His Tyr Thr 545 550 555 560 Gln Lys
Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Glu Val Gln 565 570 575
Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys 580
585 590 Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met
His 595 600 605 Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
Gly Gly Ile 610 615 620 Ser Pro Asn Ile Gly Gly Thr Ser Tyr Asn Gln
Lys Phe Lys Gly Lys 625 630 635 640 Ala Thr Leu Thr Val Asp Lys Ser
Ser Ser Thr Ala Tyr Met Glu Leu 645 650 655 Arg Ser Leu Thr Ser Glu
Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg 660 665 670 Gly Gly Ser Phe
Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 675 680 685 Ser Arg
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 690 695 700
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 705
710 715 720 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
Ala Leu 725 730 735 Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln
Asp Ser Lys Asp 740 745 750 Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr
Leu Ser Lys Ala Asp Tyr 755 760 765 Glu Lys His Lys Val Tyr Ala Cys
Glu Val Thr His Gln Gly Leu Ser 770 775 780 Ser Pro Val Thr Lys Ser
Phe Asn Arg Gly Glu Cys 785 790 795 <210> SEQ ID NO 155
<211> LENGTH: 214 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 155 Asp
Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 1 5 10
15 Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
20 25 30 Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu
Leu Ile 35 40 45 Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser
Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser
Ile Asn Ser Val Glu Pro 65 70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys
Gln Asn Gly His Ser Phe Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys Ala Ser Thr Lys Gly 100 105 110 Pro Ser Val Phe
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 115 120 125 Thr Ala
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 130 135 140
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 145
150 155 160 Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
Val Val 165 170 175 Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
Ile Cys Asn Val 180 185 190 Asn His Lys Pro Ser Asn Thr Lys Val Asp
Lys Arg Val Glu Pro Lys 195 200 205 Ser Cys Asp Lys Thr His 210
<210> SEQ ID NO 156 <211> LENGTH: 218 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 156 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys
Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> SEQ ID
NO 157 <211> LENGTH: 819 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 157 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys Gln Arg Pro
Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp Pro Gly Asp
Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly Lys Ala Thr
Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu
Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala
Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 100 105
110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys
115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 225 230
235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330 335 Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 340 345 350
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 355
360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser Leu Ser Pro
Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 450 455 460 Gly Gly
Gly Ser Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 465 470 475
480 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
485 490 495 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn 500 505 510 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
Val Leu Asp Ser 515 520 525 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
Thr Val Asp Lys Ser Arg 530 535 540 Trp Gln Gln Gly Asn Val Phe Ser
Cys Ser Val Met His Glu Ala Leu 545 550 555 560 His Asn His Tyr Thr
Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Thr 565 570 575 Gly Ser Glu
Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 580 585 590 Gly
Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 595 600
605 Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu
610 615 620 Trp Ile Gly Gly Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr
Asn Gln 625 630 635 640 Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp
Lys Ser Ser Ser Thr 645 650 655 Ala Tyr Met Glu Leu Arg Ser Leu Thr
Ser Glu Asp Ser Ala Val Tyr 660 665 670 Tyr Cys Ala Arg Arg Gly Gly
Ser Phe Asp Tyr Trp Gly Gln Gly Thr 675 680 685 Thr Leu Thr Val Ser
Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly 690 695 700 Ser Gly Gly
Ser Gly Gly Val Asp Asp Ile Val Met Thr Gln Ser Pro 705 710 715 720
Ala Thr Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg 725
730 735 Ala Ser Gln Ser Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys
Ser 740 745 750 His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln
Ser Ile Ser 755 760 765 Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser
Gly Ser Asp Phe Thr 770 775 780 Leu Ser Ile Asn Ser Val Glu Pro Glu
Asp Val Gly Val Tyr Tyr Cys 785 790 795 800 Gln Asn Gly His Ser Phe
Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 805 810 815 Glu Leu Lys
<210> SEQ ID NO 158 <211> LENGTH: 218 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 158 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys
Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> SEQ ID
NO 159 <211> LENGTH: 819 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 159 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys Gln Arg Pro
Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp Pro Gly Asp
Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly Lys Ala Thr
Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu
Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala
Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 100 105
110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys
115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys
Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu 225 230
235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330 335 Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 340 345 350
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 355
360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser Leu Ser Pro
Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 450 455 460 Gly Gly
Gly Ser Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 465 470 475
480 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
485 490 495 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn 500 505 510 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
Val Leu Asp Ser 515 520 525 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
Thr Val Asp Lys Ser Arg 530 535 540 Trp Gln Gln Gly Asn Val Phe Ser
Cys Ser Val Met His Glu Ala Leu 545 550 555 560 His Asn His Tyr Thr
Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Thr 565 570 575 Gly Ser Glu
Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 580 585 590 Gly
Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 595 600
605 Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu
610 615 620 Trp Ile Gly Gly Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr
Asn Gln 625 630 635 640 Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp
Lys Ser Ser Ser Thr 645 650 655 Ala Tyr Met Glu Leu Arg Ser Leu Thr
Ser Glu Asp Ser Ala Val Tyr 660 665 670 Tyr Cys Ala Arg Arg Gly Gly
Ser Phe Asp Tyr Trp Gly Gln Gly Thr 675 680 685 Thr Leu Thr Val Ser
Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly 690 695 700 Ser Gly Gly
Ser Gly Gly Val Asp Asp Ile Val Met Thr Gln Ser Pro 705 710 715 720
Ala Thr Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg 725
730 735 Ala Ser Gln Ser Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys
Ser 740 745 750 His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln
Ser Ile Ser 755 760 765 Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser
Gly Ser Asp Phe Thr 770 775 780 Leu Ser Ile Asn Ser Val Glu Pro Glu
Asp Val Gly Val Tyr Tyr Cys 785 790 795 800 Gln Asn Gly His Ser Phe
Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 805 810 815 Glu Leu Lys
<210> SEQ ID NO 160 <211> LENGTH: 218 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 160 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys
Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> SEQ ID
NO 161 <211> LENGTH: 815 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 161 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys Gln Arg Pro
Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp Pro Gly Asp
Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly Lys Ala Thr
Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu
Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala
Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 100 105
110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys
115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys
Ser Cys Gly Gly Gly Ser Ser Pro Ala Pro Glu Leu Leu Gly Gly 225 230
235 240 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln Tyr Ser Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val
Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 325 330 335 Lys Thr
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 355
360 365 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 450 455 460 Gly Gln
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 465 470 475
480 Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
485 490 495 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
Pro Glu 500 505 510 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe 515 520 525 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
Ser Arg Trp Gln Gln Gly 530 535 540 Asn Val Phe Ser Cys Ser Val Met
His Glu Ala Leu His Asn His Tyr 545 550 555 560 Thr Gln Lys Ser Leu
Ser Leu Ser Pro Gly Ser Thr Gly Ser Glu Val 565 570 575 Gln Leu Gln
Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val 580 585 590 Lys
Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met 595 600
605 His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly
610 615 620 Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr Asn Gln Lys Phe
Lys Gly 625 630 635 640 Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser
Thr Ala Tyr Met Glu 645 650 655 Leu Arg Ser Leu Thr Ser Glu Asp Ser
Ala Val Tyr Tyr Cys Ala Arg 660 665 670 Arg Gly Gly Ser Phe Asp Tyr
Trp Gly Gln Gly Thr Thr Leu Thr Val 675 680 685 Ser Ser Val Glu Gly
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 690 695 700 Gly Gly Val
Asp Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 705 710 715 720
Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser 725
730 735 Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser
Pro 740 745 750 Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly
Ile Pro Ser 755 760 765 Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe
Thr Leu Ser Ile Asn 770 775 780 Ser Val Glu Pro Glu Asp Val Gly Val
Tyr Tyr Cys Gln Asn Gly His 785 790 795 800 Ser Phe Pro Leu Thr Phe
Gly Ala Gly Thr Lys Leu Glu Leu Lys 805 810 815 <210> SEQ ID
NO 162 <211> LENGTH: 819 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 162 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val
Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln
Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln
Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala
Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu
Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu
Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 100 105
110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val
115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser
Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser
Ser Tyr Trp Met 145 150 155 160 Asn Trp Val Lys Gln Arg Pro Gly Gln
Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile Trp Pro Gly Asp Gly Asp
Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185 190 Lys Ala Thr Leu Thr
Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205 Leu Ser Ser
Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 210 215 220 Arg
Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp 225 230
235 240 Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Ser Ser
Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val 275 280 285 Val Asp Val Ser His Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp Gly Val Glu Val His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310 315 320 Tyr Ser Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 325 330 335 Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 340 345 350
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 355
360 365 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
Thr 370 375 380 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly Ser Phe Phe Leu Tyr 420 425 430 Ser Lys Leu Thr Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435 440 445 Ser Cys Ser Val
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 450 455 460 Ser Leu
Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 465 470 475
480 Ser Gly Gly Gly Gly Ser Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
485 490 495 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
Leu Thr 500 505 510 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu 515 520 525 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
Thr Thr Pro Pro Val Leu 530 535 540 Asp Ser Asp Gly Ser Phe Phe Leu
Tyr Ser Lys Leu Thr Val Asp Lys 545 550 555 560 Ser Arg Trp Gln Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu 565 570 575 Ala Leu His
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 580 585 590 Ser
Thr Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 595 600
605 Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr
610 615 620 Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly
Lys Ser 625 630 635 640 Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn Ile
Gly Gly Thr Ser Tyr 645 650 655 Asn Gln Lys Phe Lys Gly Lys Ala Thr
Leu Thr Val Asp Lys Ser Ser 660 665 670 Ser Thr Ala Tyr Met Glu Leu
Arg Ser Leu Thr Ser Glu Asp Ser Ala 675 680 685 Val Tyr Tyr Cys Ala
Arg Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln 690 695 700 Gly Thr Thr
Leu Thr Val Ser Ser Arg Thr Val Ala Ala Pro Ser Val 705 710 715 720
Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 725
730 735 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
Gln 740 745 750 Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
Glu Ser Val 755 760 765 Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
Leu Ser Ser Thr Leu 770 775 780 Thr Leu Ser Lys Ala Asp Tyr Glu Lys
His Lys Val Tyr Ala Cys Glu 785 790 795 800 Val Thr His Gln Gly Leu
Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 805 810 815 Gly Glu Cys
<210> SEQ ID NO 163 <211> LENGTH: 214 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 163 Asp Ile Val Met Thr Gln Ser Pro Ala Thr
Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser Cys Arg
Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr Gln Gln
Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser
Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly
Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 65 70 75 80
Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 85
90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala Ser Thr Lys
Gly 100 105 110 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
Ser Gly Gly 115 120 125 Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro Glu Pro Val 130 135 140 Thr Val Ser Trp Asn Ser Gly Ala Leu
Thr Ser Gly Val His Thr Phe 145 150 155 160 Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 165 170 175 Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 180 185 190 Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 195 200 205
Ser Cys Asp Lys Thr His 210 <210> SEQ ID NO 164 <211>
LENGTH: 819 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 164 Asp Ile Gln Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala
Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly
Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40
45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro
50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn
Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys
Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly
Ala Glu Leu Val Arg Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys
Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn
Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170
175 Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly
180 185 190 Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr
Met Gln 195 200 205 Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr
Phe Cys Ala Arg 210 215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr
Tyr Ala Met Asp Tyr Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr
Val Ser Ser Gly Gly Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295
300 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
305 310 315 320 Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
Leu His Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 420
425 430 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe 435 440 445 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr Gln Lys 450 455 460 Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly
Ser Gly Gly Gly Gly 465 470 475 480 Ser Gly Gly Gly Gly Ser Gly Gln
Pro Arg Glu Pro Gln Val Tyr Thr 485 490 495 Leu Pro Pro Ser Arg Glu
Glu Met Thr Lys Asn Gln Val Ser Leu Thr 500 505 510 Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 515 520 525 Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 530 535 540
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 545
550 555 560 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
His Glu 565 570 575 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser Pro Gly 580 585 590 Ser Thr Gly Ser Glu Val Gln Leu Gln Gln
Ser Gly Pro Glu Leu Val 595 600 605 Lys Pro Gly Ala Ser Val Lys Ile
Ser Cys Lys Thr Ser Gly Tyr Thr 610 615 620 Phe Thr Glu Tyr Thr Met
His Trp Val Lys Gln Ser His Gly Lys Ser 625 630 635 640 Leu Glu Trp
Ile Gly Gly Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr 645 650 655 Asn
Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 660 665
670 Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala
675 680 685 Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser Phe Asp Tyr Trp
Gly Gln 690 695 700 Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys
Gly Pro Ser Val 705 710 715 720 Phe Pro Leu Ala Pro Ser Ser Lys Ser
Thr Ser Gly Gly Thr Ala Ala 725 730 735 Leu Gly Cys Leu Val Lys Asp
Tyr Phe Pro Glu Pro Val Thr Val Ser 740 745 750 Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 755 760 765 Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 770 775 780 Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 785 790
795 800 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys
Asp 805 810 815 Lys Thr His <210> SEQ ID NO 165 <211>
LENGTH: 214 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 165 Asp Ile Val Met Thr
Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val
Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu
His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40
45 Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val
Glu Pro 65 70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His
Ser Phe Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro
Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys
Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp
Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170
175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> SEQ ID
NO 166 <211> LENGTH: 218 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 166 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val
Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln
Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln
Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala
Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu
Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu
Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105
110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu
Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu
Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys 210 215 <210> SEQ ID NO 167
<211> LENGTH: 792 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 167 Gln
Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10
15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr
20 25 30 Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu
Trp Ile 35 40 45 Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr
Asn Gly Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu
Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Ala Ser
Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Arg Glu Thr Thr
Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 145
150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr
Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His Lys Pro Ser Asn Thr
Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys Ser Cys Asp Lys Thr
His Thr Ser Pro Pro Ser Pro Ala Pro Glu 225 230 235 240 Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 245 250 255 Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 260 265
270 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
275 280 285 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
Tyr Ser 290 295 300 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
His Gln Asp Trp 305 310 315 320 Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys Ala Leu Pro 325 330 335 Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly Gln Pro Arg Glu 340 345 350 Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 355 360 365 Gln Val Ser
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 370 375 380 Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 385 390
395 400 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
Lys 405 410 415 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser Cys 420 425 430 Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr Gln Lys Ser Leu 435 440 445 Ser Leu Ser Pro Gly Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly 450 455 460 Gly Gly Gly Ser Gly Gln Pro
Arg Glu Pro Gln Val Tyr Thr Leu Pro 465 470 475 480 Pro Ser Arg Glu
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 485 490 495 Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 500 505 510
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 515
520 525 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
Arg 530 535 540 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
Glu Ala Leu 545 550 555 560 His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser Pro Gly Ser Thr 565 570 575 Gly Ser Asp Ile Val Met Thr Gln
Ser Pro Ala Thr Leu Ser Val Thr 580 585 590 Pro Gly Asp Arg Val Ser
Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser 595 600 605 Asp Tyr Leu His
Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu 610 615 620 Leu Ile
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe 625 630 635
640 Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val
645 650 655 Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His
Ser Phe 660 665 670 Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Ala Ser Thr 675 680 685 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
Ser Ser Lys Ser Thr Ser 690 695 700 Gly Gly Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro Glu 705 710 715 720 Pro Val Thr Val Ser
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 725 730 735 Thr Phe Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 740 745 750 Val
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 755 760
765 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu
770 775 780 Pro Lys Ser Cys Asp Lys Thr His 785 790 <210> SEQ
ID NO 168 <211> LENGTH: 223 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 168 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys
Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr
Thr Phe Thr Glu Tyr 20 25 30 Thr Met His Trp Val Lys Gln Ser His
Gly Lys Ser Leu Glu Trp Ile 35 40 45 Gly Gly Ile Ser Pro Asn Ile
Gly Gly Thr Ser Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Thr
Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu
Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 100 105
110 Thr Val Ser Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro
115 120 125 Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val
Cys Leu 130 135 140 Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln
Trp Lys Val Asp 145 150 155 160 Asn Ala Leu Gln Ser Gly Asn Ser Gln
Glu Ser Val Thr Glu Gln Asp 165 170 175 Ser Lys Asp Ser Thr Tyr Ser
Leu Ser Ser Thr Leu Thr Leu Ser Lys 180 185 190 Ala Asp Tyr Glu Lys
His Lys Val Tyr Ala Cys Glu Val Thr His Gln 195 200 205 Gly Leu Ser
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 220
<210> SEQ ID NO 169 <211> LENGTH: 445 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 169 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys
Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys 210
215 220 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val Val Asp Val Ser His
Glu Asp Pro Glu Val Lys 260 265 270 Phe Asn Trp Tyr Val Asp Gly Val
Glu Val His Asn Ala Lys Thr Lys 275 280 285 Pro Arg Glu Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu 290 295 300 Thr Val Leu His
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 305 310 315 320 Val
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 325 330
335 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
340 345 350 Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
Val Lys 355 360 365 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln 370 375 380 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly 385 390 395 400 Ser Phe Phe Leu Tyr Ser Lys
Leu Thr Val Asp Lys Ser Arg Trp Gln 405 410 415 Gln Gly Asn Val Phe
Ser Cys Ser Val Met His Glu Ala Leu His Asn 420 425 430 His Tyr Thr
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> SEQ
ID NO 170 <211> LENGTH: 680 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 170 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys Gln Arg Pro
Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp Pro Gly Asp
Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly Lys Ala Thr
Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu
Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala
Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 100 105
110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys
115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 225 230
235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu Glu Gln Tyr Asn 290 295 300 Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330 335 Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 340 345 350
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 355
360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser Leu Ser Pro
Gly Ser Thr Gly Ser Glu Val Gln Leu Gln Gln Ser 450 455 460 Gly Pro
Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys 465 470 475
480 Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln
485 490 495 Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro
Asn Ile 500 505 510 Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys
Ala Thr Leu Thr 515 520 525 Val Asp Lys Ser Ser Ser Thr Ala Tyr Met
Glu Leu Arg Ser Leu Thr 530 535 540 Ser Glu Asp Ser Ala Val Tyr Tyr
Cys Ala Arg Arg Gly Gly Ser Phe 545 550 555 560 Asp Tyr Trp Gly Gln
Gly Thr Thr Leu Thr Val Ser Ser Arg Thr Val 565 570 575 Ala Ala Pro
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 580 585 590 Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 595 600
605 Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
610 615 620 Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
Tyr Ser 625 630 635 640 Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
Tyr Glu Lys His Lys 645 650 655 Val Tyr Ala Cys Glu Val Thr His Gln
Gly Leu Ser Ser Pro Val Thr 660 665 670 Lys Ser Phe Asn Arg Gly Glu
Cys 675 680 <210> SEQ ID NO 171 <211> LENGTH: 214
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 171 Asp Ile Val Met Thr Gln Ser Pro
Ala Thr Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser
Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr
Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr
Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 65
70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe
Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala
Ser Thr Lys Gly 100 105 110 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly Gly 115 120 125 Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro Val 130 135 140 Thr Val Ser Trp Asn Ser
Gly Ala Leu Thr Ser Gly Val His Thr Phe 145 150 155 160 Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 165 170 175 Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 180 185
190 Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys
195 200 205 Ser Cys Asp Lys Thr His 210 <210> SEQ ID NO 172
<211> LENGTH: 445 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 172 Asp
Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10
15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp
20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln
Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser
Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala
Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe
Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145
150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His
Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly
Glu Cys Asp Lys Thr His Thr Cys 210 215 220 Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 225 230 235 240 Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 245 250 255 Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 260 265
270 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
275 280 285 Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser
Val Leu 290 295 300 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys 305 310 315 320 Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys 325 330 335 Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser 340 345 350 Arg Glu Glu Met Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 355 360 365 Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 370 375 380 Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 385 390
395 400 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln 405 410 415 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn 420 425 430 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 435 440 445 <210> SEQ ID NO 173 <211> LENGTH:
680 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 173 Gln Val Gln Leu Gln
Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp
Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40
45 Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr
Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala
Val Tyr Phe Cys 85 90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg
Tyr Tyr Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val
Thr Val Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170
175 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
180 185 190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
Cys Asn 195 200 205 Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
Arg Val Glu Pro 210 215 220 Lys Ser Cys Asp Lys Thr His Thr Cys Pro
Pro Cys Pro Ala Pro Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 260 265 270 Val Ser His
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser 290 295
300 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305 310 315 320 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro 325 330 335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu 340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser
Arg Glu Glu Met Thr Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420
425 430 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
Leu 435 440 445 Ser Leu Ser Pro Gly Ser Thr Gly Ser Glu Val Gln Leu
Gln Gln Ser 450 455 460 Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val
Lys Ile Ser Cys Lys 465 470 475 480 Thr Ser Gly Tyr Thr Phe Thr Glu
Tyr Thr Met His Trp Val Lys Gln 485 490 495 Ser His Gly Lys Ser Leu
Glu Trp Ile Gly Gly Ile Ser Pro Asn Ile 500 505 510 Gly Gly Thr Ser
Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 515 520 525 Val Asp
Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr 530 535 540
Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser Phe 545
550 555 560 Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Arg
Thr Val 565 570 575 Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
Glu Gln Leu Lys 580 585 590 Ser Gly Thr Ala Ser Val Val Cys Leu Leu
Asn Asn Phe Tyr Pro Arg 595 600 605 Glu Ala Lys Val Gln Trp Lys Val
Asp Asn Ala Leu Gln Ser Gly Asn 610 615 620 Ser Gln Glu Ser Val Thr
Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 625 630 635 640 Leu Ser Ser
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 645 650 655 Val
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 660 665
670 Lys Ser Phe Asn Arg Gly Glu Cys 675 680 <210> SEQ ID NO
174 <211> LENGTH: 214 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 174 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val
Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln
Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr Gln Gln Lys Ser His
Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Gln Ser Ile
Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ser
Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 65 70 75 80 Glu Asp Val
Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 85 90 95 Thr
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala Ser Thr Lys Gly 100 105
110 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
115 120 125 Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
Pro Val 130 135 140 Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
Val His Thr Phe 145 150 155 160 Pro Ala Val Leu Gln Ser Ser Gly Leu
Tyr Ser Leu Ser Ser Val Val 165 170 175 Thr Val Pro Ser Ser Ser Leu
Gly Thr Gln Thr Tyr Ile Cys Asn Val 180 185 190 Asn His Lys Pro Ser
Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 195 200 205 Ser Cys Asp
Lys Thr His 210 <210> SEQ ID NO 175 <211> LENGTH: 445
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 175 Asp Ile Gln Leu Thr Gln Ser Pro
Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser
Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr
Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu
Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65
70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln
Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe
Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val
Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185
190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Ser Asp Lys Thr His
Thr Cys 210 215 220 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys 260 265 270 Phe Asn Trp Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 275 280 285 Pro Arg Glu
Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu 290 295 300 Thr
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 305 310
315 320 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
Lys 325 330 335 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
Pro Pro Ser 340 345 350 Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu Val Lys 355 360 365 Gly Phe Tyr Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln 370 375 380 Pro Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly 385 390 395 400 Ser Phe Phe Leu
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 405 410 415 Gln Gly
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 420 425 430
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445
<210> SEQ ID NO 176 <211> LENGTH: 680 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 176 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp
Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85
90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210
215 220 Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330
335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser
Leu Ser Pro Gly Ser Thr Gly Ser Glu Val Gln Leu Gln Gln Ser 450 455
460 Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
465 470 475 480 Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp
Val Lys Gln 485 490 495 Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly
Ile Ser Pro Asn Ile 500 505 510 Gly Gly Thr Ser Tyr Asn Gln Lys Phe
Lys Gly Lys Ala Thr Leu Thr 515 520 525 Val Asp Lys Ser Ser Ser Thr
Ala Tyr Met Glu Leu Arg Ser Leu Thr 530 535 540 Ser Glu Asp Ser Ala
Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser Phe 545 550 555 560 Asp Tyr
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Arg Thr Val 565 570 575
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 580
585 590 Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro
Arg 595 600 605 Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
Ser Gly Asn 610 615 620 Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys
Asp Ser Thr Tyr Ser 625 630 635 640 Leu Ser Ser Thr Leu Thr Leu Ser
Lys Ala Asp Tyr Glu Lys His Lys 645 650 655 Val Tyr Ala Cys Glu Val
Thr His Gln Gly Leu Ser Ser Pro Val Thr 660 665 670 Lys Ser Phe Asn
Arg Gly Glu Cys 675 680 <210> SEQ ID NO 177 <211>
LENGTH: 214 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 177 Asp Ile Val Met Thr
Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val
Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu
His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40
45 Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val
Glu Pro 65 70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His
Ser Phe Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Ala Ser Thr Lys Gly 100 105 110 Pro Ser Val Phe Pro Leu Ala Pro
Ser Ser Lys Ser Thr Ser Gly Gly 115 120 125 Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 130 135 140 Thr Val Ser Trp
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 145 150 155 160 Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 165 170
175 Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
180 185 190 Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu
Pro Lys 195 200 205 Ser Cys Asp Lys Thr His 210 <210> SEQ ID
NO 178 <211> LENGTH: 445 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 178 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val
Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln
Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln
Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala
Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu
Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu
Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105
110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu
Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu
Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys 210 215 220 Pro
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 225 230
235 240 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu 245 250 255 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys 260 265 270 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys 275 280 285 Pro Arg Glu Glu Gln Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu 290 295 300 Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys 305 310 315 320 Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 325 330 335 Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 340 345 350
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 355
360 365 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln 370 375 380 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly 385 390 395 400 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln 405 410 415 Gln Gly Asn Val Phe Ser Cys Ser
Val Met His Glu Ala Leu His Asn 420 425 430 His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> SEQ ID NO 179
<211> LENGTH: 698 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 179 Gln
Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10
15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr
20 25 30 Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu
Trp Ile 35 40 45 Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr
Asn Gly Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu
Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Ala Ser
Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Arg Glu Thr Thr
Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 145
150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr
Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His Lys Pro Ser Asn Thr
Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys Ser Cys Asp Lys Thr
His Thr Cys Pro Pro Cys Pro Ala Pro Glu 225 230 235 240 Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 245 250 255 Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 260 265
270 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
275 280 285 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
Tyr Asn 290 295 300 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
His Gln Asp Trp 305 310 315 320 Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys Ala Leu Pro 325 330 335 Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly Gln Pro Arg Glu 340 345 350 Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 355 360 365 Gln Val Ser
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 370 375 380 Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 385 390
395 400 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
Lys 405 410 415 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser Cys 420 425 430 Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr Gln Lys Ser Leu 435 440 445 Ser Leu Ser Pro Gly Ser Thr Gly Ser
Glu Val Gln Leu Gln Gln Ser 450 455 460 Gly Pro Glu Leu Val Lys Pro
Gly Ala Ser Val Lys Ile Ser Cys Lys 465 470 475 480 Thr Ser Gly Tyr
Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln 485 490 495 Ser His
Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn Ile 500 505 510
Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 515
520 525 Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu
Thr 530 535 540 Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Gly
Gly Ser Phe 545 550 555 560 Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr
Val Ser Ser Val Glu Gly 565 570 575 Gly Ser Gly Gly Ser Gly Gly Ser
Gly Gly Ser Gly Gly Val Asp Asp 580 585 590 Ile Val Met Thr Gln Ser
Pro Ala Thr Leu Ser Val Thr Pro Gly Asp 595 600 605 Arg Val Ser Leu
Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu 610 615 620 His Trp
Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys 625 630 635
640 Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser
645 650 655 Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu
Pro Glu 660 665 670 Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser
Phe Pro Leu Thr 675 680 685 Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
690 695 <210> SEQ ID NO 180 <211> LENGTH: 445
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 180 Asp Ile Gln Leu Thr Gln Ser Pro
Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser
Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr
Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu
Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65
70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln
Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe
Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val
Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185
190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His
Thr Cys 210 215 220 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys 260 265 270 Phe Asn Trp Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 275 280 285 Pro Arg Glu
Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu 290 295 300 Thr
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 305 310
315 320 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
Lys 325 330 335 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
Pro Pro Ser 340 345 350 Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu Val Lys 355 360 365 Gly Phe Tyr Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln 370 375 380 Pro Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly 385 390 395 400 Ser Phe Phe Leu
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 405 410 415 Gln Gly
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 420 425 430
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445
<210> SEQ ID NO 181 <211> LENGTH: 698 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 181 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp
Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85
90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210
215 220 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330
335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser
Leu Ser Pro Gly Ser Thr Gly Ser Glu Val Gln Leu Gln Gln Ser 450 455
460 Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
465 470 475 480 Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp
Val Lys Gln 485 490 495 Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly
Ile Ser Pro Asn Ile 500 505 510 Gly Gly Thr Ser Tyr Asn Gln Lys Phe
Lys Gly Lys Ala Thr Leu Thr 515 520 525 Val Asp Lys Ser Ser Ser Thr
Ala Tyr Met Glu Leu Arg Ser Leu Thr 530 535 540 Ser Glu Asp Ser Ala
Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser Phe 545 550 555 560 Asp Tyr
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val Glu Gly 565 570 575
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp 580
585 590 Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly
Asp 595 600 605 Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser
Asp Tyr Leu 610 615 620 His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro
Arg Leu Leu Ile Lys 625 630 635 640 Tyr Ala Ser Gln Ser Ile Ser Gly
Ile Pro Ser Arg Phe Ser Gly Ser 645 650 655 Gly Ser Gly Ser Asp Phe
Thr Leu Ser Ile Asn Ser Val Glu Pro Glu 660 665 670 Asp Val Gly Val
Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu Thr 675 680 685 Phe Gly
Ala Gly Thr Lys Leu Glu Leu Lys 690 695 <210> SEQ ID NO 182
<211> LENGTH: 454 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 182 Gln
Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10
15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr
20 25 30 Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu
Trp Ile 35 40 45 Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr
Asn Gly Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu
Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Ala Ser
Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Arg Glu Thr Thr
Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 145
150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr
Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His Lys Pro Ser Asn Thr
Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys Ser Cys Asp Lys Thr
His Thr Cys Pro Pro Cys Pro Ala Pro Glu 225 230 235 240 Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 245 250 255 Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 260 265
270 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
275 280 285 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
Tyr Ser 290 295 300 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
His Gln Asp Trp 305 310 315 320 Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys Ala Leu Pro 325 330 335 Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly Gln Pro Arg Glu 340 345 350 Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 355 360 365 Gln Val Ser
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 370 375 380 Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 385 390
395 400 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
Lys 405 410 415 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser Cys 420 425 430 Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr Gln Lys Ser Leu 435 440 445 Ser Leu Ser Pro Gly Lys 450
<210> SEQ ID NO 183 <211> LENGTH: 670 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 183 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys
Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys 210
215 220 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val Val Asp Val Ser His
Glu Asp Pro Glu Val Lys 260 265 270 Phe Asn Trp Tyr Val Asp Gly Val
Glu Val His Asn Ala Lys Thr Lys 275 280 285 Pro Arg Glu Glu Gln Ser
Ser Thr Tyr Arg Val Val Ser Val Leu Thr 290 295 300 Val Leu His Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 305 310 315 320 Ser
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 325 330
335 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
340 345 350 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly 355 360 365 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln Pro 370 375 380 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser 385 390 395 400 Phe Phe Leu Tyr Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln 405 410 415 Gly Asn Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn His 420 425 430 Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Glu 435 440 445 Val
Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 450 455
460 Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr
465 470 475 480 Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu
Trp Ile Gly 485 490 495 Gly Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr
Asn Gln Lys Phe Lys 500 505 510 Gly Lys Ala Thr Leu Thr Val Asp Lys
Ser Ser Ser Thr Ala Tyr Met 515 520 525 Glu Leu Arg Ser Leu Thr Ser
Glu Asp Ser Ala Val Tyr Tyr Cys Ala 530 535 540 Arg Arg Gly Gly Ser
Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 545 550 555 560 Val Ser
Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 565 570 575
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 580
585 590 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp
Asn 595 600 605 Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu
Gln Asp Ser 610 615 620 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu
Thr Leu Ser Lys Ala 625 630 635 640 Asp Tyr Glu Lys His Lys Val Tyr
Ala Cys Glu Val Thr His Gln Gly 645 650 655 Leu Ser Ser Pro Val Thr
Lys Ser Phe Asn Arg Gly Glu Cys 660 665 670 <210> SEQ ID NO
184 <211> LENGTH: 214 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 184 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val
Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln
Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr Gln Gln Lys Ser His
Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Gln Ser Ile
Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ser
Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 65 70 75 80 Glu Asp Val
Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 85 90 95 Thr
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala Ser Thr Lys Gly 100 105
110 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
115 120 125 Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
Pro Val 130 135 140 Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
Val His Thr Phe 145 150 155 160 Pro Ala Val Leu Gln Ser Ser Gly Leu
Tyr Ser Leu Ser Ser Val Val 165 170 175 Thr Val Pro Ser Ser Ser Leu
Gly Thr Gln Thr Tyr Ile Cys Asn Val 180 185 190 Asn His Lys Pro Ser
Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 195 200 205 Ser Cys Asp
Lys Thr His 210 <210> SEQ ID NO 185 <211> LENGTH: 445
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 185 Asp Ile Gln Leu Thr Gln Ser Pro
Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser
Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr
Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu
Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65
70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln
Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe
Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val
Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185
190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His
Thr Cys 210 215 220 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val Val Asp
Val Ser His Glu Asp Pro Glu Val Lys 260 265 270 Phe Asn Trp Tyr Val
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 275 280 285 Pro Arg Glu
Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu 290 295 300 Thr
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 305 310
315 320 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
Lys 325 330 335 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
Pro Pro Ser 340 345 350 Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu Val Lys 355 360 365 Gly Phe Tyr Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln 370 375 380 Pro Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser Asp Gly 385 390 395 400 Ser Phe Phe Leu
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 405 410 415 Gln Gly
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 420 425 430
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445
<210> SEQ ID NO 186 <211> LENGTH: 671 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 186 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp
Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85
90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210
215 220 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330
335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser
Leu Ser Pro Gly Ser Thr Gly Ser Asp Ile Val Met Thr Gln Ser 450 455
460 Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys
465 470 475 480 Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His Trp Tyr
Gln Gln Lys 485 490 495 Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr
Ala Ser Gln Ser Ile 500 505 510 Ser Gly Ile Pro Ser Arg Phe Ser Gly
Ser Gly Ser Gly Ser Asp Phe 515 520 525 Thr Leu Ser Ile Asn Ser Val
Glu Pro Glu Asp Val Gly Val Tyr Tyr 530 535 540 Cys Gln Asn Gly His
Ser Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys 545 550 555 560 Leu Glu
Leu Lys Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 565 570 575
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 580
585 590 Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
Gly 595 600 605 Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
Gln Ser Ser 610 615 620 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
Pro Ser Ser Ser Leu 625 630 635 640 Gly Thr Gln Thr Tyr Ile Cys Asn
Val Asn His Lys Pro Ser Asn Thr 645 650 655 Lys Val Asp Lys Arg Val
Glu Pro Lys Ser Cys Asp Lys Thr His 660 665 670 <210> SEQ ID
NO 187 <211> LENGTH: 223 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 187 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys
Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr
Thr Phe Thr Glu Tyr 20 25 30 Thr Met His Trp Val Lys Gln Ser His
Gly Lys Ser Leu Glu Trp Ile 35 40 45 Gly Gly Ile Ser Pro Asn Ile
Gly Gly Thr Ser Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Thr
Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu
Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala
Arg Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 100 105
110 Thr Val Ser Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro
115 120 125 Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val
Cys Leu 130 135 140 Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln
Trp Lys Val Asp 145 150 155 160 Asn Ala Leu Gln Ser Gly Asn Ser Gln
Glu Ser Val Thr Glu Gln Asp 165 170 175 Ser Lys Asp Ser Thr Tyr Ser
Leu Ser Ser Thr Leu Thr Leu Ser Lys 180 185 190 Ala Asp Tyr Glu Lys
His Lys Val Tyr Ala Cys Glu Val Thr His Gln 195 200 205 Gly Leu Ser
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 220
1 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 187
<210> SEQ ID NO 1 <211> LENGTH: 304 <212> TYPE:
PRT <213> ORGANISM: homo sapiens <400> SEQUENCE: 1 Met
Ser Ser Thr Leu Pro Ala Leu Leu Cys Val Gly Leu Cys Leu Ser 1 5 10
15 Gln Arg Ile Ser Ala Gln Gln Gln Thr Leu Pro Lys Pro Phe Ile Trp
20 25 30 Ala Glu Pro His Phe Met Val Pro Lys Glu Lys Gln Val Thr
Ile Cys 35 40 45 Cys Gln Gly Asn Tyr Gly Ala Val Glu Tyr Gln Leu
His Phe Glu Gly 50 55 60 Ser Leu Phe Ala Val Asp Arg Pro Lys Pro
Pro Glu Arg Ile Asn Lys 65 70 75 80 Val Lys Phe Tyr Ile Pro Asp Met
Asn Ser Arg Met Ala Gly Gln Tyr 85 90 95 Ser Cys Ile Tyr Arg Val
Gly Glu Leu Trp Ser Glu Pro Ser Asn Leu 100 105 110 Leu Asp Leu Val
Val Thr Glu Met Tyr Asp Thr Pro Thr Leu Ser Val 115 120 125 His Pro
Gly Pro Glu Val Ile Ser Gly Glu Lys Val Thr Phe Tyr Cys 130 135 140
Arg Leu Asp Thr Ala Thr Ser Met Phe Leu Leu Leu Lys Glu Gly Arg 145
150 155 160 Ser Ser His Val Gln Arg Gly Tyr Gly Lys Val Gln Ala Glu
Phe Pro 165 170 175 Leu Gly Pro Val Thr Thr Ala His Arg Gly Thr Tyr
Arg Cys Phe Gly 180 185 190 Ser Tyr Asn Asn His Ala Trp Ser Phe Pro
Ser Glu Pro Val Lys Leu 195 200 205 Leu Val Thr Gly Asp Ile Glu Asn
Thr Ser Leu Ala Pro Glu Asp Pro 210 215 220 Thr Phe Pro Ala Asp Thr
Trp Gly Thr Tyr Leu Leu Thr Thr Glu Thr 225 230 235 240 Gly Leu Gln
Lys Asp His Ala Leu Trp Asp His Thr Ala Gln Asn Leu 245 250 255 Leu
Arg Met Gly Leu Ala Phe Leu Val Leu Val Ala Leu Val Trp Phe 260 265
270 Leu Val Glu Asp Trp Leu Ser Arg Lys Arg Thr Arg Glu Arg Ala Ser
275 280 285 Arg Ala Ser Thr Trp Glu Gly Arg Arg Arg Leu Asn Thr Gln
Thr Leu 290 295 300 <210> SEQ ID NO 2 <211> LENGTH: 216
<212> TYPE: PRT <213> ORGANISM: homo sapiens
<400> SEQUENCE: 2 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Asp Val Ser His Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45 Val Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55 60 Gln Tyr Asn
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 65 70 75 80 Gln
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90
95 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
Glu Met 115 120 125 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Thr Ser Lys Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 180 185 190 Phe Ser Cys
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 195 200 205 Lys
Ser Leu Ser Leu Ser Pro Gly 210 215 <210> SEQ ID NO 3
<211> LENGTH: 120 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 3 Gln Val Gln Leu Gln Gln Ser
Gly Pro Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser
Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Val Ile Asn
Trp Gly Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly
Glu Ile Tyr Pro Gly Ser Gly Thr Asn Tyr Tyr Asn Glu Lys Phe 50 55
60 Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Ile Ala Tyr
65 70 75 80 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr
Phe Cys 85 90 95 Ala Arg Arg Gly Arg Tyr Gly Leu Tyr Ala Met Asp
Tyr Trp Gly Gln 100 105 110 Gly Thr Ser Val Thr Val Ser Ser 115 120
<210> SEQ ID NO 4 <211> LENGTH: 107 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 4 Asp
Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10
15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr
20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu
Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser
Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr
Ile Asn Asn Leu Glu Gln 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys
Gln Gln Gly Asn Thr Arg Pro Trp 85 90 95 Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile Lys 100 105 <210> SEQ ID NO 5 <211>
LENGTH: 122 <212> TYPE: PRT <213> ORGANISM: Mus
musculus <400> SEQUENCE: 5 Glu Val Gln Leu Gln Glu Ser Gly
Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Ser Leu Ser Leu Thr Cys
Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 20 25 30 Tyr Ala Trp Asn
Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 35 40 45 Met Gly
Tyr Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 50 55 60
Glu Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Thr Asn Gln Phe Phe 65
70 75 80 Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr
Tyr Cys 85 90 95 Ala Arg Gly Gly Tyr Tyr Gly Ser Ser Trp Gly Val
Phe Ala Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ala
115 120 <210> SEQ ID NO 6 <211> LENGTH: 107 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
6 Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 1
5 10 15 Glu Thr Val Thr Ile Thr Cys Arg Val Ser Glu Asn Ile Tyr Ser
Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln
Leu Leu Val 35 40 45 Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro
Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Gln Phe Ser Leu
Lys Ile Asn Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Gly Ser Tyr Tyr
Cys Gln His His Tyr Gly Thr Pro Trp 85 90 95 Thr Phe Gly Gly Gly
Thr Lys Leu Glu Ile Lys 100 105 <210> SEQ ID NO 7 <211>
LENGTH: 116 <212> TYPE: PRT <213> ORGANISM: Mus
musculus <400> SEQUENCE: 7 Glu Val Gln Leu Gln Gln Ser Gly
Pro Glu Leu Val Lys Pro Gly Ala 1 5 10 15
Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 20
25 30 Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp
Ile 35 40 45 Gly Gly Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr Asn
Gln Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser
Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Thr Ser Glu
Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Arg Gly Gly Ser Phe
Asp Tyr Trp Gly Gln Gly Thr Thr Leu 100 105 110 Thr Val Ser Ser 115
<210> SEQ ID NO 8 <211> LENGTH: 107 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 8 Asp
Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 1 5 10
15 Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
20 25 30 Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu
Leu Ile 35 40 45 Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser
Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser
Ile Asn Ser Val Glu Pro 65 70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys
Gln Asn Gly His Ser Phe Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys 100 105 <210> SEQ ID NO 9 <211>
LENGTH: 117 <212> TYPE: PRT <213> ORGANISM: Mus
musculus <400> SEQUENCE: 9 Gln Val Gln Leu Gln Gln Ser Ala
Val Glu Leu Ala Arg Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 20 25 30 Thr Met His Trp
Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr
Ile Asn Pro Ser Ser Gly Tyr Thr Glu Tyr Asn Gln Lys Phe 50 55 60
Lys Asp Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 65
70 75 80 Met Gln Leu Asp Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr
Tyr Cys 85 90 95 Val Arg Gly Ser Ser Arg Gly Phe Asp Tyr Trp Gly
Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ala 115 <210> SEQ
ID NO 10 <211> LENGTH: 107 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 10 Asp Ile Gln Met Ile
Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 1 5 10 15 Glu Thr Val
Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 20 25 30 Leu
Ala Trp Phe Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 35 40
45 Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60 Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu
Gln Ser 65 70 75 80 Glu Asp Phe Gly Ile Tyr Tyr Cys Gln His Phe Trp
Gly Thr Pro Arg 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
Lys 100 105 <210> SEQ ID NO 11 <211> LENGTH: 115
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 11 Gln Val Gln Leu Gln Gln Pro Gly Ser Val
Leu Val Arg Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala
Ser Gly Tyr Thr Phe Thr Ser Ser 20 25 30 Trp Met His Trp Ala Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly His Ile His
Pro Asn Ser Gly Ile Ser Asn Tyr Asn Glu Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80
Val Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Gly Gly Arg Phe Asp Asp Trp Gly Ala Gly Thr Thr Val
Thr 100 105 110 Val Ser Ser 115 <210> SEQ ID NO 12
<211> LENGTH: 108 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 12 Asp Ile Val Met Thr Gln Ser
Pro Ala Thr Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu
Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp
Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys
Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55
60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro
65 70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe
Leu Met 85 90 95 Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 <210> SEQ ID NO 13 <211> LENGTH: 120
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 13 Asp Val Gln Leu Gln Glu Ser Gly Pro Gly
Leu Val Lys Pro Ser Gln 1 5 10 15 Ser Leu Ser Leu Thr Cys Thr Val
Thr Gly Tyr Ser Ile Thr Ser Asp 20 25 30 Tyr Ala Trp Asn Trp Ile
Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 35 40 45 Met Gly Tyr Ile
Thr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 50 55 60 Lys Ser
Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 65 70 75 80
Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 85
90 95 Ala Arg Cys Trp Asp Tyr Ala Leu Tyr Ala Met Asp Cys Trp Gly
Gln 100 105 110 Gly Thr Ser Val Thr Val Ser Ser 115 120 <210>
SEQ ID NO 14 <211> LENGTH: 107 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 14 Asp Ile
Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 1 5 10 15
Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr 20
25 30 Leu Ala Trp Cys Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu
Val 35 40 45 Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg
Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr His Phe Ser Leu Lys Ile
Asn Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Gly Ile Tyr Tyr Cys Gln
His His Tyr Asp Thr Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys
Leu Glu Leu Lys 100 105 <210> SEQ ID NO 15 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 15 Asp Tyr Val Ile Asn 1 5 <210> SEQ ID
NO 16 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: mus musculus <400> SEQUENCE: 16
Gly Tyr Thr Phe Thr Asp Tyr 1 5 <210> SEQ ID NO 17
<211> LENGTH: 8 <212> TYPE: PRT <213> ORGANISM:
mus musculus <400> SEQUENCE: 17 Gly Tyr Thr Phe Thr Asp Tyr
Val 1 5 <210> SEQ ID NO 18 <211> LENGTH: 17 <212>
TYPE: PRT <213> ORGANISM: mus musculus <400> SEQUENCE:
18 Glu Ile Tyr Pro Gly Ser Gly Thr Asn Tyr Tyr Asn Glu Lys Phe Lys
1 5 10 15 Ala <210> SEQ ID NO 19 <211> LENGTH: 4
<212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 19 Pro Gly Ser Gly 1 <210> SEQ ID NO 20
<211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM:
mus musculus <400> SEQUENCE: 20 Gly Tyr Thr Phe Thr Asp Tyr
Val Ile Tyr Pro Gly Ser Gly Thr Asn 1 5 10 15 <210> SEQ ID NO
21 <211> LENGTH: 11 <212> TYPE: PRT <213>
ORGANISM: mus musculus <400> SEQUENCE: 21 Arg Gly Arg Tyr Gly
Leu Tyr Ala Met Asp Tyr 1 5 10 <210> SEQ ID NO 22 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 22 Gly Arg Tyr Gly Leu Tyr Ala Met Asp 1 5
<210> SEQ ID NO 23 <211> LENGTH: 13 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 23 Ala
Arg Arg Gly Arg Tyr Gly Leu Tyr Ala Met Asp Tyr 1 5 10 <210>
SEQ ID NO 24 <211> LENGTH: 11 <212> TYPE: PRT
<213> ORGANISM: mus musculus <400> SEQUENCE: 24 Arg Ala
Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> SEQ ID NO 25
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 25 Ser Gln Asp Ile Ser Asn Tyr 1
5 <210> SEQ ID NO 26 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 26 Gln
Asp Ile Ser Asn Tyr 1 5 <210> SEQ ID NO 27 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 27 Tyr Thr Ser Arg Leu His Ser 1 5
<210> SEQ ID NO 28 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 28 Gln
Gln Gly Asn Thr Arg Pro Trp Thr 1 5 <210> SEQ ID NO 29
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 29 Tyr Thr Ser Gly Asn Thr Arg
Pro Trp 1 5 <210> SEQ ID NO 30 <211> LENGTH: 12
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 30 Tyr Thr Ser Gln Gln Gly Asn Thr Arg Pro
Trp Thr 1 5 10 <210> SEQ ID NO 31 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 31 Ser Asp Tyr Ala Trp Asn 1 5 <210>
SEQ ID NO 32 <211> LENGTH: 8 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 32 Gly Tyr
Ser Ile Thr Ser Asp Tyr 1 5 <210> SEQ ID NO 33 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 33 Gly Tyr Ser Ile Thr Ser Asp Tyr Ala 1 5
<210> SEQ ID NO 34 <211> LENGTH: 16 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 34 Tyr
Ile Thr Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Glu Ser 1 5 10
15 <210> SEQ ID NO 35 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 35 Ile
Thr Tyr Ser Gly Ser Thr 1 5 <210> SEQ ID NO 36 <211>
LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 36 Gly Gly Tyr Tyr Gly Ser Ser Trp Gly Val
Phe Ala Tyr 1 5 10 <210> SEQ ID NO 37 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 37 Gly Tyr Tyr Gly Ser Ser Trp Gly Val Phe
Ala 1 5 10 <210> SEQ ID NO 38 <211> LENGTH: 15
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 38 Ala Arg Gly Gly Tyr Tyr Gly Ser Ser Trp
Gly Val Phe Ala Tyr 1 5 10 15 <210> SEQ ID NO 39 <211>
LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 39 Arg Val Ser Glu Asn Ile Tyr Ser Tyr Leu
Ala 1 5 10 <210> SEQ ID NO 40 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 40 Ser Glu Asn Ile Tyr Ser Tyr 1 5
<210> SEQ ID NO 41 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 41 Glu
Asn Ile Tyr Ser Tyr 1 5 <210> SEQ ID NO 42 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 42 Asn Ala Lys Thr Leu Ala Glu 1 5
<210> SEQ ID NO 43 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 43 Gln
His His Tyr Gly Thr Pro Trp Thr 1 5 <210> SEQ ID NO 44
<211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 44 His Tyr Gly Thr Pro Trp 1 5
<210> SEQ ID NO 45 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 45 Gln
His His Tyr Gly Thr Pro Trp Thr 1 5 <210> SEQ ID NO 46
<211> LENGTH: 5 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 46 Glu Tyr Thr Met His 1 5
<210> SEQ ID NO 47 <211> LENGTH: 7 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 47 Gly
Tyr Thr Phe Thr Glu Tyr 1 5 <210> SEQ ID NO 48 <211>
LENGTH: 8 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 48 Gly Tyr Thr Phe Thr Glu Tyr Thr 1 5
<210> SEQ ID NO 49 <211> LENGTH: 17 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 49 Gly
Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 1 5 10
15 Gly <210> SEQ ID NO 50 <211> LENGTH: 8 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
50 Ile Ser Pro Asn Ile Gly Gly Thr 1 5 <210> SEQ ID NO 51
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 51 Arg Gly Gly Ser Phe Asp Tyr 1
5 <210> SEQ ID NO 52 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 52 Gly
Gly Ser Phe Asp 1 5 <210> SEQ ID NO 53 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 53 Ala Arg Arg Gly Gly Ser Phe Asp Tyr 1 5
<210> SEQ ID NO 54 <211> LENGTH: 11 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 54 Arg
Ala Ser Gln Ser Ile Ser Asp Tyr Leu His 1 5 10 <210> SEQ ID
NO 55 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 55 Ser Gln Ser Ile Ser
Asp Tyr 1 5 <210> SEQ ID NO 56 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 56 Gln Ser Ile Ser Asp Tyr 1 5 <210>
SEQ ID NO 57 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 57 Tyr Ala
Ser Gln Ser Ile Ser 1 5 <210> SEQ ID NO 58 <211>
LENGTH: 9 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 58 Gln Asn Gly His Ser Phe Pro Leu Thr 1 5
<210> SEQ ID NO 59 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 59 Gly
His Ser Phe Pro Leu 1 5 <210> SEQ ID NO 60 <211>
LENGTH: 5 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 60 Ser Phe Thr Met His 1 5 <210> SEQ ID
NO 61 <211> LENGTH: 7 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 61 Gly Tyr Thr Phe Thr
Ser Phe 1 5
<210> SEQ ID NO 62 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 62 Gly
Tyr Thr Phe Thr Ser Phe Thr 1 5 <210> SEQ ID NO 63
<211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 63 Tyr Ile Asn Pro Ser Ser Gly
Tyr Thr Glu Tyr Asn Gln Lys Phe Lys 1 5 10 15 Asp <210> SEQ
ID NO 64 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 64 Ile Asn Pro Ser Ser
Gly Tyr Thr 1 5 <210> SEQ ID NO 65 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 65 Gly Ser Ser Arg Gly Phe Asp Tyr 1 5
<210> SEQ ID NO 66 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 66 Ser
Ser Arg Gly Phe Asp 1 5 <210> SEQ ID NO 67 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 67 Val Arg Gly Ser Ser Arg Gly Phe Asp Tyr 1
5 10 <210> SEQ ID NO 68 <211> LENGTH: 11 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
68 Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 1 5 10 <210>
SEQ ID NO 69 <211> LENGTH: 6 <212> TYPE: PRT
<213> ORGANISM: Mus musculur <400> SEQUENCE: 69 Glu Asn
Ile Tyr Ser Asn 1 5 <210> SEQ ID NO 70 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: mus musculur
<400> SEQUENCE: 70 Ala Ala Thr Asn Leu Ala Asp 1 5
<210> SEQ ID NO 71 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 71 Gln
His Phe Trp Gly Thr Pro Arg Thr 1 5 <210> SEQ ID NO 72
<211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 72 Phe Trp Gly Thr Pro Arg 1 5
<210> SEQ ID NO 73 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 73 Ser
Ser Trp Met His 1 5 <210> SEQ ID NO 74 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 74 Gly Tyr Thr Phe Thr Ser Ser 1 5
<210> SEQ ID NO 75 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 75 Gly
Tyr Thr Phe Thr Ser Ser Trp 1 5 <210> SEQ ID NO 76
<211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 76 His Ile His Pro Asn Ser Gly
Ile Ser Asn Tyr Asn Glu Lys Phe Lys 1 5 10 15 Gly <210> SEQ
ID NO 77 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 77 Ile His Pro Asn Ser
Gly Ile Ser 1 5 <210> SEQ ID NO 78 <211> LENGTH: 6
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 78 Gly Gly Arg Phe Asp Asp 1 5 <210>
SEQ ID NO 79 <211> LENGTH: 8 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 79 Ala Arg
Gly Gly Arg Phe Asp Asp 1 5 <210> SEQ ID NO 80 <211>
LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 80 Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu
His 1 5 10 <210> SEQ ID NO 81 <211> LENGTH: 11
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 81 Gly Arg Phe Asp Ser Gln Ser Ile Ser Asp
Tyr 1 5 10 <210> SEQ ID NO 82 <211> LENGTH: 10
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 82 Gln Asn Gly His Ser Phe Leu Met Tyr Thr 1
5 10 <210> SEQ ID NO 83 <211> LENGTH: 7 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
83 Gly His Ser Phe Leu Met Tyr 1 5 <210> SEQ ID NO 84
<211> LENGTH: 13 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 84 Tyr Ala
Ser Gln Asn Gly His Ser Phe Leu Met Tyr Thr 1 5 10 <210> SEQ
ID NO 85 <211> LENGTH: 6 <212> TYPE: PRT <213>
ORGANISM: mus musculus <400> SEQUENCE: 85 Ser Asp Tyr Ala Trp
Asn 1 5 <210> SEQ ID NO 86 <211> LENGTH: 8 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
86 Gly Tyr Ser Ile Thr Ser Asp Tyr 1 5 <210> SEQ ID NO 87
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 87 Gly Tyr Ser Ile Thr Ser Asp
Tyr Ala 1 5 <210> SEQ ID NO 88 <211> LENGTH: 16
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 88 Tyr Ile Thr Tyr Ser Gly Ser Thr Asn Tyr
Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> SEQ ID NO 89
<211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 89 Cys Trp Asp Tyr Ala Leu Tyr
Ala Met Asp Cys 1 5 10 <210> SEQ ID NO 90 <211> LENGTH:
9 <212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 90 Trp Asp Tyr Ala Leu Tyr Ala Met Asp 1 5
<210> SEQ ID NO 91 <211> LENGTH: 13 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 91 Ala
Arg Cys Trp Asp Tyr Ala Leu Tyr Ala Met Asp Cys 1 5 10 <210>
SEQ ID NO 92 <211> LENGTH: 11 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 92 Arg Thr
Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 1 5 10 <210> SEQ ID NO 93
<211> LENGTH: 7 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 93 Asn Ala Lys Thr Leu Ala Glu 1
5 <210> SEQ ID NO 94 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 94 Gln
His His Tyr Asp Thr Pro Leu Thr 1 5 <210> SEQ ID NO 95
<211> LENGTH: 9 <212> TYPE: PRT <213> ORGANISM:
mus musculus <400> SEQUENCE: 95 Asn Ala Lys His Tyr Asp Thr
Pro Leu 1 5 <210> SEQ ID NO 96 <211> LENGTH: 9
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 96 Gln His His Tyr Asp Thr Pro Leu Thr 1 5
<210> SEQ ID NO 97 <211> LENGTH: 5 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 97 Asn
Tyr Gly Met Asn 1 5 <210> SEQ ID NO 98 <211> LENGTH: 7
<212> TYPE: PRT <213> ORGANISM: mus musculus
<400> SEQUENCE: 98 Gly Tyr Thr Phe Thr Asn Tyr 1 5
<210> SEQ ID NO 99 <211> LENGTH: 8 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 99 Gly
Tyr Thr Phe Thr Asn Tyr Gly 1 5 <210> SEQ ID NO 100
<211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM:
mus musculus <400> SEQUENCE: 100 Trp Ile Asn Thr Asn Thr Gly
Glu Pro Thr Tyr Ala Glu Glu Phe Lys 1 5 10 15 Gly <210> SEQ
ID NO 101 <211> LENGTH: 8 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 101 Ile Asn Thr Asn
Thr Gly Glu Pro 1 5 <210> SEQ ID NO 102 <211> LENGTH: 8
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 102 Asp Tyr Leu Tyr Tyr Phe Asp Tyr 1 5
<210> SEQ ID NO 103 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 103
Tyr Leu Tyr Tyr Phe Asp 1 5 <210> SEQ ID NO 104 <211>
LENGTH: 10 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 104 Ala Arg Asp Tyr Leu Tyr Tyr Phe Asp Tyr 1
5 10 <210> SEQ ID NO 105 <211> LENGTH: 11 <212>
TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE:
105 Lys Ala Ser Glu Asn Val Val Thr Tyr Val Ser 1 5 10 <210>
SEQ ID NO 106 <211> LENGTH: 7 <212> TYPE: PRT
<213> ORGANISM: Mus musculus <400> SEQUENCE: 106 Ser
Glu Asn Val Val Thr Tyr 1 5
<210> SEQ ID NO 107 <211> LENGTH: 6 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 107
Glu Asn Val Val Thr Tyr 1 5 <210> SEQ ID NO 108 <211>
LENGTH: 7 <212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 108 Gly Ala Ser Asn Arg Tyr Thr 1 5
<210> SEQ ID NO 109 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 109
Gly Gln Gly Tyr Ser Tyr Pro Tyr Thr 1 5 <210> SEQ ID NO 110
<211> LENGTH: 6 <212> TYPE: PRT <213> ORGANISM:
mus musculus <400> SEQUENCE: 110 Gly Tyr Ser Tyr Pro Tyr 1 5
<210> SEQ ID NO 111 <211> LENGTH: 9 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 111
Gly Gln Gly Tyr Ser Tyr Pro Tyr Thr 1 5 <210> SEQ ID NO 112
<211> LENGTH: 227 <212> TYPE: PRT <213> ORGANISM:
homo sapiens <400> SEQUENCE: 112 Gly Gln Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg Glu 1 5 10 15 Glu Met Thr Lys Asn
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 20 25 30 Tyr Pro Ser
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 35 40 45 Asn
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 50 55
60 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65 70 75 80 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
His Tyr 85 90 95 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly
Gly Gly Ser Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gln Pro Arg Glu Pro Gln 115 120 125 Val Tyr Thr Leu Pro Pro Ser Arg
Glu Glu Met Thr Lys Asn Gln Val 130 135 140 Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 145 150 155 160 Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 165 170 175 Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 180 185
190 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
195 200 205 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
Ser Leu 210 215 220 Ser Pro Gly 225 <210> SEQ ID NO 113
<211> LENGTH: 333 <212> TYPE: DNA <213> ORGANISM:
mus musculus <400> SEQUENCE: 113 gacattcagc tgacccaatc
tccagcttct ttggctgtgt ctctagggca gagggccacc 60 atctcctgca
aggccagcca aagtgttgat tatgatggtg atagttattt gaactggtac 120
caacagatac caggacagcc acccaaactc ctcatctatg atgcatccaa tctagtatct
180 gggattccac ccaggtttag tggcagtggg tctgggacag acttcaccct
caacatccat 240 cctgtggaga aggtggatgc tgcaacctat cactgtcagc
aaagtactga ggacccttgg 300 acgttcggtg gaggcaccaa gctggaaatc aaa 333
<210> SEQ ID NO 114 <211> LENGTH: 111 <212> TYPE:
PRT <213> ORGANISM: mus musculus <400> SEQUENCE: 114
Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5
10 15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr
Asp 20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly
Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val
Ser Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala
Ala Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> SEQ
ID NO 115 <211> LENGTH: 372 <212> TYPE: DNA <213>
ORGANISM: mus musculus <400> SEQUENCE: 115 caggttcagc
tgcagcagtc tggggctgag ctggtgcggc ctgggtcctc agtgaagatt 60
tcctgcaaag catctggcta cgcattcagt agctactgga tgaactgggt gaagcagagg
120 cctggacagg gtcttgagtg gattggacag atttggcctg gagatggtga
tactaactac 180 aacggaaagt tcaagggcaa ggccacactg actgcagacg
aatcctccag cacagcctac 240 atgcagctca gcagcctggc ctctgaggac
tctgcggtct atttctgtgc aagacgagaa 300 acgaccactg tcgggcgtta
ttactatgct atggactact ggggtcaagg aaccacagtc 360 accgtctcct ca 372
<210> SEQ ID NO 116 <211> LENGTH: 124 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 116
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5
10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser
Tyr 20 25 30 Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu
Glu Trp Ile 35 40 45 Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn
Tyr Asn Gly Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp
Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Ala
Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Arg Glu Thr
Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 100 105 110 Tyr Trp Gly
Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> SEQ ID NO
117 <211> LENGTH: 648 <212> TYPE: DNA <213>
ORGANISM: homo sapiens <400> SEQUENCE: 117 gcacctgaac
tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc 60
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac
120 cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc
caagacaaag 180 ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca
gcgtcctcac cgtcctgcac 240 caggactggc tgaatggcaa ggagtacaag
tgcaaggtct ccaacaaagc cctcccagcc 300 cccatcgaga aaaccatctc
caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 360 aagcccccat
cccgggagga gatgaccaag aaccaggtca gcctgtcctg cctggtcaaa 420
ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac
480 tacaagacca cggttcccgt gctggactcc gacggctcct tccgcctcgc
tagctacctc 540 accgtggaca agagcaggtg gcagcagggg aacgtcttct
catgctccgt gatgcatgag 600 gctctgcaca accactacac gcagaagagc
ctctccctgt ccccgggg 648 <210> SEQ ID NO 118 <211>
LENGTH: 718 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 118
Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5
10 15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr
Asp 20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly
Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val
Ser Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr
Asp Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala
Ala Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 100 105 110 Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Gln
Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val 130 135
140 Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met
145 150 155 160 Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp
Ile Gly Gln 165 170 175 Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn
Gly Lys Phe Lys Gly 180 185 190 Lys Ala Thr Leu Thr Ala Asp Glu Ser
Ser Ser Thr Ala Tyr Met Gln 195 200 205 Leu Ser Ser Leu Ala Ser Glu
Asp Ser Ala Val Tyr Phe Cys Ala Arg 210 215 220 Arg Glu Thr Thr Thr
Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp 225 230 235 240 Gly Gln
Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Ser Ser Ala 245 250 255
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 260
265 270 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
Val 275 280 285 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
Trp Tyr Val 290 295 300 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu Glu Gln 305 310 315 320 Tyr Asn Ser Thr Tyr Arg Val Val
Ser Val Leu Thr Val Leu His Gln 325 330 335 Asp Trp Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 340 345 350 Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 355 360 365 Arg Glu
Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Glu Glu Met Thr 370 375 380
Lys Asn Gln Val Ser Leu Ser Cys Leu Val Lys Gly Phe Tyr Pro Ser 385
390 395 400 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
Asn Tyr 405 410 415 Lys Thr Thr Val Pro Val Leu Asp Ser Asp Gly Ser
Phe Arg Leu Ala 420 425 430 Ser Tyr Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val Phe 435 440 445 Ser Cys Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr Gln Lys 450 455 460 Ser Leu Ser Leu Ser Pro
Gly Ser Thr Gly Ser Asp Ile Lys Leu Gln 465 470 475 480 Gln Ser Gly
Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser 485 490 495 Cys
Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val 500 505
510 Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro
515 520 525 Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys
Ala Thr 530 535 540 Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met
Gln Leu Ser Ser 545 550 555 560 Leu Thr Ser Glu Asp Ser Ala Val Tyr
Tyr Cys Ala Arg Tyr Tyr Asp 565 570 575 Asp His Tyr Cys Leu Asp Tyr
Trp Gly Gln Gly Thr Thr Leu Thr Val 580 585 590 Ser Ser Val Glu Gly
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 595 600 605 Gly Gly Val
Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser 610 615 620 Ala
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 625 630
635 640 Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro
Lys 645 650 655 Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val
Pro Tyr Arg 660 665 670 Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser
Leu Thr Ile Ser Ser 675 680 685 Met Glu Ala Glu Asp Ala Ala Thr Tyr
Tyr Cys Gln Gln Trp Ser Ser 690 695 700 Asn Pro Leu Thr Phe Gly Ala
Gly Thr Lys Leu Glu Leu Lys 705 710 715 <210> SEQ ID NO 119
<211> LENGTH: 249 <212> TYPE: PRT <213> ORGANISM:
mus musculus <400> SEQUENCE: 119 Ser Thr Gly Ser Gln Val Gln
Leu Gln Gln Ser Gly Pro Glu Leu Val 1 5 10 15 Lys Pro Gly Ala Ser
Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 20 25 30 Phe Thr Asp
Tyr Val Ile Asn Trp Gly Lys Gln Arg Ser Gly Gln Gly 35 40 45 Leu
Glu Trp Ile Gly Glu Ile Tyr Pro Gly Ser Gly Thr Asn Tyr Tyr 50 55
60 Asn Glu Lys Phe Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser
65 70 75 80 Asn Ile Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp
Ser Ala 85 90 95 Val Tyr Phe Cys Ala Arg Arg Gly Arg Tyr Gly Leu
Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Ser Val Thr Val
Ser Ser Val Glu Gly Gly 115 120 125 Ser Gly Gly Ser Gly Gly Ser Gly
Gly Ser Gly Gly Val Asp Asp Ile 130 135 140 Gln Met Thr Gln Thr Thr
Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg 145 150 155 160 Val Thr Ile
Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 165 170 175 Trp
Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr 180 185
190 Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
195 200 205 Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asn Asn Leu Glu Gln
Glu Asp 210 215 220 Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Arg
Pro Trp Thr Phe 225 230 235 240 Gly Gly Gly Thr Lys Leu Glu Ile Lys
245 <210> SEQ ID NO 120 <211> LENGTH: 251 <212>
TYPE: PRT <213> ORGANISM: mus musculus <400> SEQUENCE:
120 Ser Thr Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val
1 5 10 15 Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly
Tyr Ser 20 25 30 Ile Thr Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln
Phe Pro Gly Asn 35 40 45 Lys Leu Glu Trp Met Gly Tyr Ile Thr Tyr
Ser Gly Ser Thr Ser Tyr 50 55 60 Asn Pro Ser Leu Glu Ser Arg Ile
Ser Ile Thr Arg Asp Thr Ser Thr 65 70 75 80 Asn Gln Phe Phe Leu Gln
Leu Asn Ser Val Thr Thr Glu Asp Thr Ala 85 90 95 Thr Tyr Tyr Cys
Ala Arg Gly Gly Tyr Tyr Gly Ser Ser Trp Gly Val 100 105 110 Phe Ala
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Val Glu 115 120 125
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp 130
135 140 Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val
Gly 145 150 155 160 Glu Thr Val Thr Ile Thr Cys Arg Val Ser Glu Asn
Ile Tyr Ser Tyr 165 170 175 Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys
Ser Pro Gln Leu Leu Val 180 185 190 Tyr Asn Ala Lys Thr Leu Ala Glu
Gly Val Pro Ser Arg Phe Ser Gly 195 200 205 Ser Gly Ser Gly Thr Gln
Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 210 215 220 Glu Asp Phe Gly
Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Trp 225 230 235 240 Thr
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 245 250 <210> SEQ ID
NO 121 <211> LENGTH: 245 <212> TYPE: PRT
<213> ORGANISM: mus musculus <400> SEQUENCE: 121 Ser
Thr Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 1 5 10
15 Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr
20 25 30 Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly
Lys Ser 35 40 45 Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn Ile Gly
Gly Thr Ser Tyr 50 55 60 Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu
Thr Val Asp Lys Ser Ser 65 70 75 80 Ser Thr Ala Tyr Met Glu Leu Arg
Ser Leu Thr Ser Glu Asp Ser Ala 85 90 95 Val Tyr Tyr Cys Ala Arg
Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Thr Leu
Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser 115 120 125 Gly Gly
Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Val Met Thr Gln 130 135 140
Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser 145
150 155 160 Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His Trp Tyr
Gln Gln 165 170 175 Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr
Ala Ser Gln Ser 180 185 190 Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
Ser Gly Ser Gly Ser Asp 195 200 205 Phe Thr Leu Ser Ile Asn Ser Val
Glu Pro Glu Asp Val Gly Val Tyr 210 215 220 Tyr Cys Gln Asn Gly His
Ser Phe Pro Leu Thr Phe Gly Ala Gly Thr 225 230 235 240 Lys Leu Glu
Leu Lys 245 <210> SEQ ID NO 122 <211> LENGTH: 246
<212> TYPE: PRT <213> ORGANISM: Mus musculus
<400> SEQUENCE: 122 Ser Thr Gly Ser Gln Val Gln Leu Gln Gln
Ser Ala Val Glu Leu Ala 1 5 10 15 Arg Pro Gly Ala Ser Val Lys Met
Ser Cys Lys Ala Ser Gly Tyr Thr 20 25 30 Phe Thr Ser Phe Thr Met
His Trp Val Lys Gln Arg Pro Gly Gln Gly 35 40 45 Leu Glu Trp Ile
Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Glu Tyr 50 55 60 Asn Gln
Lys Phe Lys Asp Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser 65 70 75 80
Ser Thr Ala Tyr Met Gln Leu Asp Ser Leu Thr Ser Asp Asp Ser Ala 85
90 95 Val Tyr Tyr Cys Val Arg Gly Ser Ser Arg Gly Phe Asp Tyr Trp
Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ala Val Glu Gly Gly
Ser Gly Gly 115 120 125 Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp
Asp Ile Gln Met Ile 130 135 140 Gln Ser Pro Ala Ser Leu Ser Val Ser
Val Gly Glu Thr Val Thr Ile 145 150 155 160 Thr Cys Arg Ala Ser Glu
Asn Ile Tyr Ser Asn Leu Ala Trp Phe Gln 165 170 175 Gln Lys Gln Gly
Lys Ser Pro Gln Leu Leu Val Tyr Ala Ala Thr Asn 180 185 190 Leu Ala
Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205
Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser Glu Asp Phe Gly Ile 210
215 220 Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Arg Thr Phe Gly Gly
Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> SEQ ID
NO 123 <211> LENGTH: 245 <212> TYPE: PRT <213>
ORGANISM: Mus musculus <400> SEQUENCE: 123 Ser Thr Gly Ser
Gln Val Gln Leu Gln Gln Pro Gly Ser Val Leu Val 1 5 10 15 Arg Pro
Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr 20 25 30
Phe Thr Ser Ser Trp Met His Trp Ala Lys Gln Arg Pro Gly Gln Gly 35
40 45 Leu Glu Trp Ile Gly His Ile His Pro Asn Ser Gly Ile Ser Asn
Tyr 50 55 60 Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp
Thr Ser Ser 65 70 75 80 Ser Thr Ala Tyr Val Asp Leu Ser Ser Leu Thr
Ser Glu Asp Ser Ala 85 90 95 Val Tyr Tyr Cys Ala Arg Gly Gly Arg
Phe Asp Asp Trp Gly Ala Gly 100 105 110 Thr Thr Val Thr Val Ser Ser
Val Glu Gly Gly Ser Gly Gly Ser Gly 115 120 125 Gly Ser Gly Gly Ser
Gly Gly Val Asp Asp Ile Val Met Thr Gln Ser 130 135 140 Pro Ala Thr
Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys 145 150 155 160
Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys 165
170 175 Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser
Ile 180 185 190 Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
Ser Asp Phe 195 200 205 Thr Leu Ser Ile Asn Ser Val Glu Pro Glu Asp
Val Gly Val Tyr Tyr 210 215 220 Cys Gln Asn Gly His Ser Phe Leu Met
Tyr Thr Phe Gly Gly Gly Thr 225 230 235 240 Lys Leu Glu Ile Lys 245
<210> SEQ ID NO 124 <211> LENGTH: 249 <212> TYPE:
PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 124
Ser Thr Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 1 5
10 15 Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr
Ser 20 25 30 Ile Thr Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe
Pro Gly Asn 35 40 45 Lys Leu Glu Trp Met Gly Tyr Ile Thr Tyr Ser
Gly Ser Thr Asn Tyr 50 55 60 Asn Pro Ser Leu Lys Ser Arg Ile Ser
Ile Thr Arg Asp Thr Ser Lys 65 70 75 80 Asn Gln Phe Phe Leu Gln Leu
Asn Ser Val Thr Thr Glu Asp Thr Ala 85 90 95 Thr Tyr Tyr Cys Ala
Arg Cys Trp Asp Tyr Ala Leu Tyr Ala Met Asp 100 105 110 Cys Trp Gly
Gln Gly Thr Ser Val Thr Val Ser Ser Val Glu Gly Gly 115 120 125 Ser
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile 130 135
140 Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr
145 150 155 160 Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser
Tyr Leu Ala 165 170 175 Trp Cys Gln Gln Lys Gln Gly Lys Ser Pro Gln
Leu Leu Val Tyr Asn 180 185 190 Ala Lys Thr Leu Ala Glu Gly Val Pro
Ser Arg Phe Ser Gly Ser Gly 195 200 205 Ser Gly Thr His Phe Ser Leu
Lys Ile Asn Ser Leu Gln Pro Glu Asp 210 215 220 Phe Gly Ile Tyr Tyr
Cys Gln His His Tyr Asp Thr Pro Leu Thr Phe 225 230 235 240 Gly Ala
Gly Thr Lys Leu Glu Leu Lys 245 <210> SEQ ID NO 125
<211> LENGTH: 246 <212> TYPE: PRT <213> ORGANISM:
Mus musculus <400> SEQUENCE: 125 Ser Thr Gly Ser Gln Ile Gln
Leu Val Gln Ser Gly Pro Glu Leu Gln 1 5 10 15 Lys Pro Gly Glu Thr
Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr 20 25 30 Phe Thr Asn
Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly 35 40 45 Leu
Lys Trp Met Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr 50 55
60 Ala Glu Glu Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala
65 70 75 80 Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp
Thr Ala 85 90 95 Thr Tyr Phe Cys Ala Arg Asp Tyr Leu Tyr Tyr Phe
Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Thr Leu Thr Val Ser Ser Val
Glu Gly Gly Ser Gly Gly 115 120 125
Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asn Ile Val Met Thr 130
135 140 Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly Glu Arg Val Thr
Leu 145 150 155 160 Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr Val
Ser Trp Tyr Gln 165 170 175 Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu
Ile Tyr Gly Ala Ser Asn 180 185 190 Arg Tyr Thr Gly Val Pro Asp Arg
Phe Thr Gly Ser Gly Ser Ala Thr 195 200 205 Asp Phe Thr Leu Thr Ile
Ser Ser Val Gln Ala Glu Asp Leu Ala Asp 210 215 220 Tyr His Cys Gly
Gln Gly Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly 225 230 235 240 Thr
Lys Leu Glu Ile Lys 245 <210> SEQ ID NO 126 <211>
LENGTH: 751 <212> TYPE: DNA <213> ORGANISM: mus
musculus <400> SEQUENCE: 126 gtcgactgga agccaggtac agctgcagca
gtctggccct gaactcgtca aaccaggagc 60 ttccgtgaag atgtcctgca
aggcttcagg gtacacgttt accgactatg tgatcaattg 120 gggtaagcag
cgctctgggc aaggcttgga gtggattggc gagatctatc ctgggagtgg 180
gaccaactat tacaacgaga agttcaaggc caaagccact ttgactgcag acaagagctc
240 aaacattgcc tacatgcaac tgagctccct gacatcagag gattctgctg
tgtacttctg 300 tgcacgtaga ggtcggtacg gtctgtatgc catggactat
tggggccaag gcacttccgt 360 gacagtcagc tctgtggaag gaggaagtgg
cggttcagga ggtagcggag ggtccggagg 420 agtggatgac attcagatga
cacagaccac ttctagcctc tccgcatccc ttggggatag 480 ggtcaccatc
agttgtaggg ctagccagga catttccaat tacctgaact ggtatcagca 540
gaaacccgat ggcacagtta agcttctgat ctactacaca agcagactgc actcaggggt
600 tccatctcgg tttagtggaa gtggctctgg taccgactat tccctgacca
tcaacaatct 660 ggaacaggaa gatatcgcca cctacttctg ccaacagggc
aatactcgac cctggacatt 720 tggtggcggc acgaaactcg agataaaata a 751
<210> SEQ ID NO 127 <211> LENGTH: 757 <212> TYPE:
DNA <213> ORGANISM: Mus musculus <400> SEQUENCE: 127
gtcgactgga tccgaggtac agttgcagga gagtgggcct ggactggtca aaccctccca
60 atctctgagc ttgacatgca cagtcacagg ctacagcatc acctccgact
acgcttggaa 120 ttggattcga cagtttcccg gcaacaagct ggaatggatg
ggctacatca cctatagtgg 180 tagcacttcc tataatccct cacttgagag
ccggatttcc atcactaggg atacgagcac 240 caaccagttc ttcctgcagc
tgaatagcgt caccaccgaa gatactgcca cctattactg 300 cgcaagaggc
ggttactatg gcagttcatg gggtgtattc gcctattggg gacaggggac 360
acttgtgaca gtgtctgctg ttgaaggtgg atccggcgga tcaggaggga gtggtggcag
420 tggaggtgtt gacgacattc agatgaccca atcccctgct tctctctcag
cctctgtggg 480 agagactgtg accataacct gtcgtgttag cgagaacatc
tactcctatc tcgcctggta 540 tcagcagaaa caggggaaat ccccacaact
gctcgtgtac aatgccaaga ctctggcaga 600 aggagtgcca agccgctttt
ccgggtctgg gtctgggaca cagttctcac tgaagatcaa 660 ctctttgcaa
cctgaggatt ttggctctta ctactgtcag catcactatg gcacaccatg 720
gacgtttggt ggcggcacta agctggagat taagtaa 757 <210> SEQ ID NO
128 <211> LENGTH: 739 <212> TYPE: DNA <213>
ORGANISM: Mus musculus <400> SEQUENCE: 128 gtcgactggg
tccgaagtgc aactgcaaca gtctggccct gagctggtca aacccggtgc 60
ttcagtgaag atctcctgca agacatccgg ctacaccttc actgagtaca ccatgcactg
120 ggtcaaacag tctcacggta agagcctgga gtggataggc ggaatttcac
ccaacattgg 180 agggacctcc tataaccaga agttcaaggg caaagccacc
cttacagttg acaagagcag 240 ttcaactgcc tacatggaac tgcgctcatt
gacctccgag gattcagccg tgtattactg 300 cgctagaagg ggaggatcct
tcgattattg gggccaaggc actacgctta ccgtgagcag 360 cgttgaaggt
ggttctggcg gctctggtgg aagtggaggg agtggcgggg tagacgacat 420
cgtgatgact cagagtccag caactctgtc cgttacacct ggagatcgag tgtctctgag
480 ttgtcgtgca agccagtcta tctctgacta tctgcactgg tatcagcaga
agagccatga 540 gtcacctagg ctgttgatca agtacgcctc tcagtccatt
agcgggattc catcccggtt 600 tagtggctct ggctccggta gtgacttcac
actcagcatc aatagcgtcg aaccagagga 660 tgtaggggtg tactactgtc
agaatgggca ttcctttccc ctcacatttg gagctggtac 720 caaactcgag
ctgaaataa 739 <210> SEQ ID NO 129 <211> LENGTH: 742
<212> TYPE: DNA <213> ORGANISM: Mus musculus
<400> SEQUENCE: 129 gtcgactggc tcccaagtac agcttcagca
gtctgccgtc gaacttgctc gaccaggagc 60 ttcagtgaag atgagctgca
aagcctctgg ttacaccttc acgtccttta ccatgcattg 120 ggtgaagcag
cgtcctggcc aaggcctgga gtggattggc tacatcaatc cctccagcgg 180
gtataccgag tacaaccaga agttcaagga caaaacaacc ctgactgccg ataagtcaag
240 tagcacagcc tatatgcagc tggattccct gacatcagac gatagcgctg
tgtattactg 300 cgttaggggc tctagcagag ggttcgacta ttggggtcaa
ggcacactgg tcacggttag 360 tgccgttgaa ggaggctctg gaggcagtgg
aggttctgga gggtcaggcg gtgtggatga 420 cattcagatg attcagagtc
ccgctagctt gagtgtaagc gtcggtgaga cagtgaccat 480 cacttgtcgc
gcatccgaaa acatctactc caatctcgca tggttccagc agaaacaggg 540
caaatcaccc caattgctcg tgtatgccgc aactaatctg gctgatggtg tgccttccag
600 gtttagcggg tctggatctg ggactcagta ctccctgaag atcaactccc
tccagtctga 660 ggacttcggg atctattact gtcagcactt ttggggaact
ccacggacct ttggaggcgg 720 gaccaaactg gagataaagt aa 742 <210>
SEQ ID NO 130 <211> LENGTH: 696 <212> TYPE: DNA
<213> ORGANISM: Mus musculus <400> SEQUENCE: 130
ctggtgaggc caggtgcatc tgtgaagctg tcatgcaaag catccgggta cacgttcacc
60 tcttcatgga tgcattgggc caaacagcgt ccaggccagg gccttgagtg
gattggacac 120 attcacccca atagcggcat atccaactac aacgagaagt
tcaagggcaa agccacactg 180 acagtggata cttccagctc tacagcctat
gtggacctta gtagcttgac cagtgaggat 240 tctgccgtat actactgtgc
tagaggtggg cggtttgacg attggggtgc tgggaccaca 300 gtcaccgtga
gcagtgtcga aggtggatca ggtggatctg gaggctcagg cggttctggc 360
ggtgttgacg acatcgtgat gactcaaagc cctgctactc tctctgtcac acccggagat
420 agggtaagcc tcagttgtcg agcaagccag tcaatcagcg actatctgca
ctggtatcag 480 cagaagtccc atgaatcccc acgcttgctc atcaagtacg
ccagtcagtc catcagtggc 540 attccttccc ggttttctgg gtctggatcc
gggtcagact tcactctgag cattaactcc 600 gtcgaacccg aggatgttgg
cgtgtattat tgccagaatg gacattcctt cctgatgtac 660 acctttggcg
gagggaccaa actggagatc aagtaa 696 <210> SEQ ID NO 131
<211> LENGTH: 751 <212> TYPE: DNA <213> ORGANISM:
Mus musculus <400> SEQUENCE: 131 gtcgactggg tctgatgtgc
agttgcagga gtcaggacct gggcttgtca agccaagcca 60 gagcctcagt
ctcacttgca ctgtcacagg ctatagcatc acatccgact atgcttggaa 120
ttggattagg cagtttcctg gcaataagct ggaatggatg gggtacatca cctattccgg
180 cagtaccaac tacaatccca gcttgaaatc tcggatttcc ataacacgcg
atactagcaa 240 gaaccagttc ttccttcagc tgaactctgt gacaacagag
gataccgcta cgtactattg 300 cgccagatgc tgggattacg ccctgtatgc
catggactgt tggggtcaag gtaccagcgt 360 tactgtgtct agcgtcgaag
gcggaagtgg cggctcagga gggtcaggag gctcaggcgg 420 agtggatgac
attcagatga cccaatctcc cgcatccctg tccgcatcag taggggagac 480
agtgaccatt acctgtcgta cttccgagaa catctactcc tatcttgcct ggtgtcaaca
540 gaaacagggg aaaagtccac agctgctggt gtataacgcc aagaccttgg
cagaaggtgt 600 tcccagtcga ttctctggtt ccggatccgg tacacacttc
agcctgaaga tcaattctct 660 gcaaccagag gactttggaa tctactactg
ccagcatcac tacgacactc ctctgacgtt 720 tggcgctggt accaagctcg
aactgaaata a 751 <210> SEQ ID NO 132 <211> LENGTH: 742
<212> TYPE: DNA <213> ORGANISM: Mus musculus
<400> SEQUENCE: 132 gtcgactggt agccagatac agctggtaca
gtcaggacca gagctgcaga aacctggaga 60 gacagtgaag atcagctgca
aggctagcgg gtacaccttc acgaattacg ggatgaactg 120 ggtcaagcag
gctccaggca aagggctgaa gtggatgggc tggattaaca ccaatactgg 180
ggaaccaacc tatgccgagg aattcaaggg gagatttgcc ttttccctcg aaaccagcgc
240 ctcaaccgcc tatctccaga tcaacaacct gaagaatgag gataccgcta
cctacttctg 300 tgcaagggac tacctctact acttcgacta ttggggccaa
ggtacgactc ttacagtctc 360 tagtgttgag ggagggagtg gaggttctgg
aggctctggt ggctctggag gcgttgacaa 420 catcgtgatg actcagtctc
ccaaaagcat gagtatgagt gtgggtgaac gagttacctt 480
gacatgcaaa gcctccgaga atgtcgtgac atacgtgtcc tggtatcagc agaaacccga
540 gcaatcccct aagctgctga tctatggcgc tagcaatcgc tatactggcg
tacctgatcg 600 gttcacagga tcaggctcag ccactgactt tactcttacc
atttcctccg tgcaggcaga 660 agatttggca gattaccact gtgggcaagg
ttactcttat ccctatacat ttggaggcgg 720 cacaaagctg gagattaagt aa 742
<210> SEQ ID NO 133 <211> LENGTH: 720 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 133 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val Lys Gln Arg
Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile Trp Pro Gly
Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185 190 Lys Ala
Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205
Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 210
215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr
Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly
Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val Ser His Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310 315 320 Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 325 330
335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg
Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Ser Cys Leu Val
Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr Thr Val Pro
Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala 420 425 430 Ser Tyr Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435 440 445 Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 450 455
460 Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Gln Val Gln Leu Gln
465 470 475 480 Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val
Lys Met Ser 485 490 495 Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
Val Ile Asn Trp Gly 500 505 510 Lys Gln Arg Ser Gly Gln Gly Leu Glu
Trp Ile Gly Glu Ile Tyr Pro 515 520 525 Gly Ser Gly Thr Asn Tyr Tyr
Asn Glu Lys Phe Lys Ala Lys Ala Thr 530 535 540 Leu Thr Ala Asp Lys
Ser Ser Asn Ile Ala Tyr Met Gln Leu Ser Ser 545 550 555 560 Leu Thr
Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg Gly Arg 565 570 575
Tyr Gly Leu Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 580
585 590 Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly
Gly 595 600 605 Ser Gly Gly Val Asp Asp Ile Gln Met Thr Gln Thr Thr
Ser Ser Leu 610 615 620 Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser
Cys Arg Ala Ser Gln 625 630 635 640 Asp Ile Ser Asn Tyr Leu Asn Trp
Tyr Gln Gln Lys Pro Asp Gly Thr 645 650 655 Val Lys Leu Leu Ile Tyr
Tyr Thr Ser Arg Leu His Ser Gly Val Pro 660 665 670 Ser Arg Phe Ser
Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 675 680 685 Asn Asn
Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 690 695 700
Asn Thr Arg Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 705
710 715 720 <210> SEQ ID NO 134 <211> LENGTH: 722
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 134 Asp Ile Gln Leu Thr Gln Ser Pro
Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser
Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr
Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu
Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65
70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln
Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val
Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile
Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185
190 Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln
195 200 205 Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys
Ala Arg 210 215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala
Met Asp Tyr Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser
Ser Gly Gly Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310
315 320 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Lys Pro
Pro Ser Arg Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Ser
Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr
Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala 420 425 430
Ser Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435
440 445 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
Lys 450 455 460
Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Glu Val Gln Leu Gln 465
470 475 480 Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser Leu Ser
Leu Thr 485 490 495 Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Tyr
Ala Trp Asn Trp 500 505 510 Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu
Trp Met Gly Tyr Ile Thr 515 520 525 Tyr Ser Gly Ser Thr Ser Tyr Asn
Pro Ser Leu Glu Ser Arg Ile Ser 530 535 540 Ile Thr Arg Asp Thr Ser
Thr Asn Gln Phe Phe Leu Gln Leu Asn Ser 545 550 555 560 Val Thr Thr
Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Gly Gly Tyr 565 570 575 Tyr
Gly Ser Ser Trp Gly Val Phe Ala Tyr Trp Gly Gln Gly Thr Leu 580 585
590 Val Thr Val Ser Ala Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser
595 600 605 Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Met Thr Gln Ser
Pro Ala 610 615 620 Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile
Thr Cys Arg Val 625 630 635 640 Ser Glu Asn Ile Tyr Ser Tyr Leu Ala
Trp Tyr Gln Gln Lys Gln Gly 645 650 655 Lys Ser Pro Gln Leu Leu Val
Tyr Asn Ala Lys Thr Leu Ala Glu Gly 660 665 670 Val Pro Ser Arg Phe
Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu 675 680 685 Lys Ile Asn
Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln 690 695 700 His
His Tyr Gly Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 705 710
715 720 Ile Lys <210> SEQ ID NO 135 <211> LENGTH: 716
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 135 Asp Ile Gln Leu Thr Gln Ser Pro
Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser
Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr
Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu
Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65
70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln
Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val
Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile
Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185
190 Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln
195 200 205 Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys
Ala Arg 210 215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala
Met Asp Tyr Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser
Ser Gly Gly Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro
Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310
315 320 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Lys Pro
Pro Ser Arg Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Ser
Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr
Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala 420 425 430
Ser Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435
440 445 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
Lys 450 455 460 Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Glu Val
Gln Leu Gln 465 470 475 480 Gln Ser Gly Pro Glu Leu Val Lys Pro Gly
Ala Ser Val Lys Ile Ser 485 490 495 Cys Lys Thr Ser Gly Tyr Thr Phe
Thr Glu Tyr Thr Met His Trp Val 500 505 510 Lys Gln Ser His Gly Lys
Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro 515 520 525 Asn Ile Gly Gly
Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 530 535 540 Leu Thr
Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 545 550 555
560 Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Gly Gly
565 570 575 Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser
Ser Val 580 585 590 Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly
Ser Gly Gly Val 595 600 605 Asp Asp Ile Val Met Thr Gln Ser Pro Ala
Thr Leu Ser Val Thr Pro 610 615 620 Gly Asp Arg Val Ser Leu Ser Cys
Arg Ala Ser Gln Ser Ile Ser Asp 625 630 635 640 Tyr Leu His Trp Tyr
Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu 645 650 655 Ile Lys Tyr
Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser 660 665 670 Gly
Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu 675 680
685 Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro
690 695 700 Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 705 710
715 <210> SEQ ID NO 136 <211> LENGTH: 717 <212>
TYPE: PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 136 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val Lys Gln Arg
Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile Trp Pro Gly
Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185 190 Lys Ala
Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205
Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 210
215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr
Trp 225 230 235 240
Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Ser Ser Ala 245
250 255 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
Pro 260 265 270 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
Cys Val Val 275 280 285 Val Asp Val Ser His Glu Asp Pro Glu Val Lys
Phe Asn Trp Tyr Val 290 295 300 Asp Gly Val Glu Val His Asn Ala Lys
Thr Lys Pro Arg Glu Glu Gln 305 310 315 320 Tyr Asn Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln 325 330 335 Asp Trp Leu Asn
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 340 345 350 Leu Pro
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 355 360 365
Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Glu Glu Met Thr 370
375 380 Lys Asn Gln Val Ser Leu Ser Cys Leu Val Lys Gly Phe Tyr Pro
Ser 385 390 395 400 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr 405 410 415 Lys Thr Thr Val Pro Val Leu Asp Ser Asp
Gly Ser Phe Arg Leu Ala 420 425 430 Ser Tyr Leu Thr Val Asp Lys Ser
Arg Trp Gln Gln Gly Asn Val Phe 435 440 445 Ser Cys Ser Val Met His
Glu Ala Leu His Asn His Tyr Thr Gln Lys 450 455 460 Ser Leu Ser Leu
Ser Pro Gly Ser Thr Gly Ser Gln Val Gln Leu Gln 465 470 475 480 Gln
Ser Ala Val Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser 485 490
495 Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe Thr Met His Trp Val
500 505 510 Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile
Asn Pro 515 520 525 Ser Ser Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys
Asp Lys Thr Thr 530 535 540 Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala
Tyr Met Gln Leu Asp Ser 545 550 555 560 Leu Thr Ser Asp Asp Ser Ala
Val Tyr Tyr Cys Val Arg Gly Ser Ser 565 570 575 Arg Gly Phe Asp Tyr
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 580 585 590 Val Glu Gly
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 595 600 605 Val
Asp Asp Ile Gln Met Ile Gln Ser Pro Ala Ser Leu Ser Val Ser 610 615
620 Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr
625 630 635 640 Ser Asn Leu Ala Trp Phe Gln Gln Lys Gln Gly Lys Ser
Pro Gln Leu 645 650 655 Leu Val Tyr Ala Ala Thr Asn Leu Ala Asp Gly
Val Pro Ser Arg Phe 660 665 670 Ser Gly Ser Gly Ser Gly Thr Gln Tyr
Ser Leu Lys Ile Asn Ser Leu 675 680 685 Gln Ser Glu Asp Phe Gly Ile
Tyr Tyr Cys Gln His Phe Trp Gly Thr 690 695 700 Pro Arg Thr Phe Gly
Gly Gly Thr Lys Leu Glu Ile Lys 705 710 715 <210> SEQ ID NO
137 <211> LENGTH: 716 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 137 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val
Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln
Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln
Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala
Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu
Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu
Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 100 105
110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val
115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser
Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser
Ser Tyr Trp Met 145 150 155 160 Asn Trp Val Lys Gln Arg Pro Gly Gln
Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile Trp Pro Gly Asp Gly Asp
Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185 190 Lys Ala Thr Leu Thr
Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205 Leu Ser Ser
Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 210 215 220 Arg
Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp 225 230
235 240 Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Ser Ser
Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
Val Thr Cys Val Val 275 280 285 Val Asp Val Ser His Glu Asp Pro Glu
Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp Gly Val Glu Val His Asn
Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310 315 320 Tyr Asn Ser Thr
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 325 330 335 Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 340 345 350
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 355
360 365 Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Glu Glu Met
Thr 370 375 380 Lys Asn Gln Val Ser Leu Ser Cys Leu Val Lys Gly Phe
Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr Thr Val Pro Val Leu Asp
Ser Asp Gly Ser Phe Arg Leu Ala 420 425 430 Ser Tyr Leu Thr Val Asp
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435 440 445 Ser Cys Ser Val
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 450 455 460 Ser Leu
Ser Leu Ser Pro Gly Ser Thr Gly Ser Gln Val Gln Leu Gln 465 470 475
480 Gln Pro Gly Ser Val Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser
485 490 495 Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser Trp Met His
Trp Ala 500 505 510 Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly
His Ile His Pro 515 520 525 Asn Ser Gly Ile Ser Asn Tyr Asn Glu Lys
Phe Lys Gly Lys Ala Thr 530 535 540 Leu Thr Val Asp Thr Ser Ser Ser
Thr Ala Tyr Val Asp Leu Ser Ser 545 550 555 560 Leu Thr Ser Glu Asp
Ser Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg 565 570 575 Phe Asp Asp
Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Val Glu 580 585 590 Gly
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp 595 600
605 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly
610 615 620 Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser
Asp Tyr 625 630 635 640 Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser
Pro Arg Leu Leu Ile 645 650 655 Lys Tyr Ala Ser Gln Ser Ile Ser Gly
Ile Pro Ser Arg Phe Ser Gly 660 665 670 Ser Gly Ser Gly Ser Asp Phe
Thr Leu Ser Ile Asn Ser Val Glu Pro 675 680 685 Glu Asp Val Gly Val
Tyr Tyr Cys Gln Asn Gly His Ser Phe Leu Met 690 695 700 Tyr Thr Phe
Gly Gly Gly Thr Lys Leu Glu Ile Lys 705 710 715 <210> SEQ ID
NO 138 <211> LENGTH: 720 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 138 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val
Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln
Ser Val Asp Tyr Asp 20 25 30
Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35
40 45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro
Pro 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
Asn Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His
Cys Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly
Thr Lys Leu Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser
Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser
Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 145 150 155 160
Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165
170 175 Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys
Gly 180 185 190 Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala
Tyr Met Gln 195 200 205 Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val
Tyr Phe Cys Ala Arg 210 215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr
Tyr Tyr Ala Met Asp Tyr Trp 225 230 235 240 Gly Gln Gly Thr Thr Val
Thr Val Ser Ser Gly Gly Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 275 280 285
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290
295 300 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
Gln 305 310 315 320 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
Val Leu His Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys Val Ser Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr
Thr Lys Pro Pro Ser Arg Glu Glu Met Thr 370 375 380 Lys Asn Gln Val
Ser Leu Ser Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410
415 Lys Thr Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala
420 425 430 Ser Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
Val Phe 435 440 445 Ser Cys Ser Val Met His Glu Ala Leu His Asn His
Tyr Thr Gln Lys 450 455 460 Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly
Ser Asp Val Gln Leu Gln 465 470 475 480 Glu Ser Gly Pro Gly Leu Val
Lys Pro Ser Gln Ser Leu Ser Leu Thr 485 490 495 Cys Thr Val Thr Gly
Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn Trp 500 505 510 Ile Arg Gln
Phe Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Thr 515 520 525 Tyr
Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser 530 535
540 Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser
545 550 555 560 Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg
Cys Trp Asp 565 570 575 Tyr Ala Leu Tyr Ala Met Asp Cys Trp Gly Gln
Gly Thr Ser Val Thr 580 585 590 Val Ser Ser Val Glu Gly Gly Ser Gly
Gly Ser Gly Gly Ser Gly Gly 595 600 605 Ser Gly Gly Val Asp Asp Ile
Gln Met Thr Gln Ser Pro Ala Ser Leu 610 615 620 Ser Ala Ser Val Gly
Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu 625 630 635 640 Asn Ile
Tyr Ser Tyr Leu Ala Trp Cys Gln Gln Lys Gln Gly Lys Ser 645 650 655
Pro Gln Leu Leu Val Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro 660
665 670 Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Ser Leu Lys
Ile 675 680 685 Asn Ser Leu Gln Pro Glu Asp Phe Gly Ile Tyr Tyr Cys
Gln His His 690 695 700 Tyr Asp Thr Pro Leu Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys 705 710 715 720 <210> SEQ ID NO 139
<211> LENGTH: 717 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 139 Asp
Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10
15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp
20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln
Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser
Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala
Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe
Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu
Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val 130 135 140
Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 145
150 155 160 Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
Gly Gln 165 170 175 Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly
Lys Phe Lys Gly 180 185 190 Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser
Ser Thr Ala Tyr Met Gln 195 200 205 Leu Ser Ser Leu Ala Ser Glu Asp
Ser Ala Val Tyr Phe Cys Ala Arg 210 215 220 Arg Glu Thr Thr Thr Val
Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp 225 230 235 240 Gly Gln Gly
Thr Thr Val Thr Val Ser Ser Gly Gly Gly Ser Ser Ala 245 250 255 Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265
270 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
275 280 285 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
Tyr Val 290 295 300 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
Arg Glu Glu Gln 305 310 315 320 Tyr Asn Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu His Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys Val Ser Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro
Gln Val Tyr Thr Lys Pro Pro Ser Arg Glu Glu Met Thr 370 375 380 Lys
Asn Gln Val Ser Leu Ser Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390
395 400 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
Tyr 405 410 415 Lys Thr Thr Val Pro Val Leu Asp Ser Asp Gly Ser Phe
Arg Leu Ala 420 425 430 Ser Tyr Leu Thr Val Asp Lys Ser Arg Trp Gln
Gln Gly Asn Val Phe 435 440 445 Ser Cys Ser Val Met His Glu Ala Leu
His Asn His Tyr Thr Gln Lys 450 455 460 Ser Leu Ser Leu Ser Pro Gly
Ser Thr Gly Ser Gln Ile Gln Leu Val 465 470 475 480 Gln Ser Gly Pro
Glu Leu Gln Lys Pro Gly Glu Thr Val Lys Ile Ser 485 490 495 Cys Lys
Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val 500 505 510
Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr 515
520 525 Asn Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe Lys Gly Arg Phe
Ala 530 535 540 Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln
Ile Asn Asn 545 550 555 560 Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe
Cys Ala Arg Asp Tyr Leu 565 570 575 Tyr Tyr Phe Asp Tyr Trp Gly Gln
Gly Thr Thr Leu Thr Val Ser Ser 580 585 590 Val Glu Gly Gly Ser Gly
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly
595 600 605 Val Asp Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser
Met Ser 610 615 620 Val Gly Glu Arg Val Thr Leu Thr Cys Lys Ala Ser
Glu Asn Val Val 625 630 635 640 Thr Tyr Val Ser Trp Tyr Gln Gln Lys
Pro Glu Gln Ser Pro Lys Leu 645 650 655 Leu Ile Tyr Gly Ala Ser Asn
Arg Tyr Thr Gly Val Pro Asp Arg Phe 660 665 670 Thr Gly Ser Gly Ser
Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 675 680 685 Gln Ala Glu
Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr 690 695 700 Pro
Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 705 710 715
<210> SEQ ID NO 140 <211> LENGTH: 698 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 140 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val Lys Gln Arg
Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile Trp Pro Gly
Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185 190 Lys Ala
Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205
Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 210
215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr
Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly
Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val Ser His Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310 315 320 Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 325 330
335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg
Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Ser Cys Leu Val
Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr Thr Val Pro
Val Leu Asp Ser Asp Gly Ser Phe Arg Leu Ala 420 425 430 Ser Tyr Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435 440 445 Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 450 455
460 Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Glu Val Gln Leu Gln
465 470 475 480 Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val
Lys Ile Ser 485 490 495 Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr
Thr Met His Trp Val 500 505 510 Lys Gln Ser His Gly Lys Ser Leu Glu
Trp Ile Gly Gly Ile Ser Pro 515 520 525 Asn Ile Gly Gly Thr Ser Tyr
Asn Gln Lys Phe Lys Gly Lys Ala Thr 530 535 540 Leu Thr Val Asp Lys
Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 545 550 555 560 Leu Thr
Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Gly Gly 565 570 575
Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala 580
585 590 Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
Ser 595 600 605 Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
Asp Tyr Phe 610 615 620 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
Ala Leu Thr Ser Gly 625 630 635 640 Val His Thr Phe Pro Ala Val Leu
Gln Ser Ser Gly Leu Tyr Ser Leu 645 650 655 Ser Ser Val Val Thr Val
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 660 665 670 Ile Cys Asn Val
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 675 680 685 Val Glu
Pro Lys Ser Cys Asp Lys Thr His 690 695 <210> SEQ ID NO 141
<211> LENGTH: 214 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 141 Asp
Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 1 5 10
15 Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
20 25 30 Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu
Leu Ile 35 40 45 Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser
Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser
Ile Asn Ser Val Glu Pro 65 70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys
Gln Asn Gly His Ser Phe Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe
Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145
150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser
Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210
<210> SEQ ID NO 142 <211> LENGTH: 837 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 142 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gln Val 115 120 125
Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val 130
135 140 Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp
Met 145 150 155 160 Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu
Trp Ile Gly Gln 165 170 175 Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr
Asn Gly Lys Phe Lys Gly 180 185 190 Lys Ala Thr Leu Thr Ala Asp Glu
Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205 Leu Ser Ser Leu Ala Ser
Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 210 215 220 Arg Glu Thr Thr
Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp 225 230 235 240 Gly
Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Ser Ser Ala 245 250
255 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
260 265 270 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
Val Val 275 280 285 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
Asn Trp Tyr Val 290 295 300 Asp Gly Val Glu Val His Asn Ala Lys Thr
Lys Pro Arg Glu Glu Gln 305 310 315 320 Tyr Asn Ser Thr Tyr Arg Val
Val Ser Val Leu Thr Val Leu His Gln 325 330 335 Asp Trp Leu Asn Gly
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 340 345 350 Leu Pro Ala
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 355 360 365 Arg
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 370 375
380 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
385 390 395 400 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
Asn Asn Tyr 405 410 415 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
Ser Phe Phe Leu Tyr 420 425 430 Ser Lys Leu Thr Val Asp Lys Ser Arg
Trp Gln Gln Gly Asn Val Phe 435 440 445 Ser Cys Ser Val Met His Glu
Ala Leu His Asn His Tyr Thr Gln Lys 450 455 460 Ser Leu Ser Leu Ser
Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 465 470 475 480 Ser Gly
Gly Gly Gly Ser Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 485 490 495
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 500
505 510 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
Glu 515 520 525 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
Pro Val Leu 530 535 540 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
Leu Thr Val Asp Lys 545 550 555 560 Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser Cys Ser Val Met His Glu 565 570 575 Ala Leu His Asn His Tyr
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 580 585 590 Ser Thr Gly Ser
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 595 600 605 Lys Pro
Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr 610 615 620
Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser 625
630 635 640 Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn Ile Gly Gly Thr
Ser Tyr 645 650 655 Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val
Asp Lys Ser Ser 660 665 670 Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu
Thr Ser Glu Asp Ser Ala 675 680 685 Val Tyr Tyr Cys Ala Arg Arg Gly
Gly Ser Phe Asp Tyr Trp Gly Gln 690 695 700 Gly Thr Thr Leu Thr Val
Ser Ser Val Glu Gly Gly Ser Gly Gly Ser 705 710 715 720 Gly Gly Ser
Gly Gly Ser Gly Gly Val Asp Asp Ile Val Met Thr Gln 725 730 735 Ser
Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser 740 745
750 Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln
755 760 765 Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser
Gln Ser 770 775 780 Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly
Ser Gly Ser Asp 785 790 795 800 Phe Thr Leu Ser Ile Asn Ser Val Glu
Pro Glu Asp Val Gly Val Tyr 805 810 815 Tyr Cys Gln Asn Gly His Ser
Phe Pro Leu Thr Phe Gly Ala Gly Thr 820 825 830 Lys Leu Glu Leu Lys
835 <210> SEQ ID NO 143 <211> LENGTH: 837 <212>
TYPE: PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 143 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp Val Lys Gln Arg
Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile Trp Pro Gly
Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185 190 Lys Ala
Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205
Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 210
215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr
Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly
Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met Ile Ser Arg
Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp Val Ser His Glu
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp Gly Val Glu
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310 315 320 Tyr
Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 325 330
335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr Thr Pro Pro
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 420 425 430 Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435 440 445 Ser
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 450 455
460 Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly
465 470 475 480 Ser Gly Gly Gly Gly Ser Gly Gln Pro Arg Glu Pro Gln
Val Tyr Thr 485 490 495 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
Gln Val Ser Leu Thr 500 505 510 Cys Leu Val Lys Gly Phe Tyr Pro Ser
Asp Ile Ala Val Glu Trp Glu 515 520 525 Ser Asn Gly Gln Pro Glu Asn
Asn Tyr Lys Thr Thr Pro Pro Val Leu 530 535 540 Asp Ser Asp Gly Ser
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 545 550 555 560 Ser Arg
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
565 570 575 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
Pro Gly 580 585 590 Ser Thr Gly Ser Glu Val Gln Leu Gln Gln Ser Gly
Pro Glu Leu Val 595 600 605 Lys Pro Gly Ala Ser Val Lys Ile Ser Cys
Lys Thr Ser Gly Tyr Thr 610 615 620 Phe Thr Glu Tyr Thr Met His Trp
Val Lys Gln Ser His Gly Lys Ser 625 630 635 640 Leu Glu Trp Ile Gly
Gly Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr 645 650 655 Asn Gln Lys
Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 660 665 670 Ser
Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 675 680
685 Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln
690 695 700 Gly Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly
Gly Ser 705 710 715 720 Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp
Ile Val Met Thr Gln 725 730 735 Ser Pro Ala Thr Leu Ser Val Thr Pro
Gly Asp Arg Val Ser Leu Ser 740 745 750 Cys Arg Ala Ser Gln Ser Ile
Ser Asp Tyr Leu His Trp Tyr Gln Gln 755 760 765 Lys Ser His Glu Ser
Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser 770 775 780 Ile Ser Gly
Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp 785 790 795 800
Phe Thr Leu Ser Ile Asn Ser Val Glu Pro Glu Asp Val Gly Val Tyr 805
810 815 Tyr Cys Gln Asn Gly His Ser Phe Pro Leu Thr Phe Gly Ala Gly
Thr 820 825 830 Lys Leu Glu Leu Lys 835 <210> SEQ ID NO 144
<211> LENGTH: 218 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 144 Asp
Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10
15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp
20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln
Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser
Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala
Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe
Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145
150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His
Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly
Glu Cys 210 215 <210> SEQ ID NO 145 <211> LENGTH: 675
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 145 Gln Val Gln Leu Gln Gln Ser Gly
Ala Glu Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys
Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp
Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln
Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65
70 75 80 Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr
Phe Cys 85 90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr
Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val
Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala
Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185
190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
195 200 205 Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val
Glu Pro 210 215 220 Lys Ser Cys Gly Gly Gly Ser Ser Ala Pro Glu Leu
Leu Gly Gly Pro 225 230 235 240 Ser Val Phe Leu Phe Pro Pro Lys Pro
Lys Asp Thr Leu Met Ile Ser 245 250 255 Arg Thr Pro Glu Val Thr Cys
Val Val Val Asp Val Ser His Glu Asp 260 265 270 Pro Glu Val Lys Phe
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 275 280 285 Ala Lys Thr
Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val 290 295 300 Val
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 305 310
315 320 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
Lys 325 330 335 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
Val Tyr Thr 340 345 350 Lys Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
Gln Val Ser Leu Ser 355 360 365 Cys Leu Val Lys Gly Phe Tyr Pro Ser
Asp Ile Ala Val Glu Trp Glu 370 375 380 Ser Asn Gly Gln Pro Glu Asn
Asn Tyr Lys Thr Thr Val Pro Val Leu 385 390 395 400 Asp Ser Asp Gly
Ser Phe Arg Leu Ala Ser Tyr Leu Thr Val Asp Lys 405 410 415 Ser Arg
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 420 425 430
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435
440 445 Ser Thr Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu
Val 450 455 460 Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser
Gly Tyr Thr 465 470 475 480 Phe Thr Glu Tyr Thr Met His Trp Val Lys
Gln Ser His Gly Lys Ser 485 490 495 Leu Glu Trp Ile Gly Gly Ile Ser
Pro Asn Ile Gly Gly Thr Ser Tyr 500 505 510 Asn Gln Lys Phe Lys Gly
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 515 520 525 Ser Thr Ala Tyr
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 530 535 540 Val Tyr
Tyr Cys Ala Arg Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln 545 550 555
560 Gly Thr Thr Leu Thr Val Ser Ser Arg Thr Val Ala Ala Pro Ser Val
565 570 575 Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
Ala Ser 580 585 590 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
Ala Lys Val Gln 595 600 605 Trp Lys Val Asp Asn Ala Leu Gln Ser Gly
Asn Ser Gln Glu Ser Val 610 615 620 Thr Glu Gln Asp Ser Lys Asp Ser
Thr Tyr Ser Leu Ser Ser Thr Leu 625 630 635 640 Thr Leu Ser Lys Ala
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 645 650 655 Val Thr His
Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 660 665 670 Gly
Glu Cys 675 <210> SEQ ID NO 146 <211> LENGTH: 214
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus
<400> SEQUENCE: 146 Asp Ile Val Met Thr Gln Ser Pro Ala Thr
Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser Cys Arg
Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr Gln Gln
Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser
Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly
Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 65 70 75 80
Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 85
90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala Ser Thr Lys
Gly 100 105 110 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
Ser Gly Gly 115 120 125 Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro Glu Pro Val 130 135 140 Thr Val Ser Trp Asn Ser Gly Ala Leu
Thr Ser Gly Val His Thr Phe 145 150 155 160 Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 165 170 175 Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 180 185 190 Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 195 200 205
Ser Cys Asp Lys Thr His 210 <210> SEQ ID NO 147 <211>
LENGTH: 218 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 147 Asp Ile Gln Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala
Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly
Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40
45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro
50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn
Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys
Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe
Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170
175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215
<210> SEQ ID NO 148 <211> LENGTH: 801 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 148 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp
Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85
90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210
215 220 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330
335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser
Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 450 455
460 Gly Gly Gly Ser Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
465 470 475 480 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
Thr Cys Leu 485 490 495 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
Glu Trp Glu Ser Asn 500 505 510 Gly Gln Pro Glu Asn Asn Tyr Lys Thr
Thr Pro Pro Val Leu Asp Ser 515 520 525 Asp Gly Ser Phe Phe Leu Tyr
Ser Lys Leu Thr Val Asp Lys Ser Arg 530 535 540 Trp Gln Gln Gly Asn
Val Phe Ser Cys Ser Val Met His Glu Ala Leu 545 550 555 560 His Asn
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Thr 565 570 575
Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 580
585 590 Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe
Thr 595 600 605 Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly Lys
Ser Leu Glu 610 615 620 Trp Ile Gly Gly Ile Ser Pro Asn Ile Gly Gly
Thr Ser Tyr Asn Gln 625 630 635 640 Lys Phe Lys Gly Lys Ala Thr Leu
Thr Val Asp Lys Ser Ser Ser Thr 645 650 655 Ala Tyr Met Glu Leu Arg
Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 660 665 670 Tyr Cys Ala Arg
Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 675 680 685 Thr Leu
Thr Val Ser Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile 690 695 700
Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 705
710 715 720 Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln
Trp Lys 725 730 735 Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
Ser Val Thr Glu 740 745 750 Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
Ser Ser Thr Leu Thr Leu 755 760 765
Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 770
775 780 His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly
Glu 785 790 795 800 Cys <210> SEQ ID NO 149 <211>
LENGTH: 214 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 149 Asp Ile Val Met Thr
Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val
Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu
His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40
45 Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val
Glu Pro 65 70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His
Ser Phe Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Ala Ser Thr Lys Gly 100 105 110 Pro Ser Val Phe Pro Leu Ala Pro
Ser Ser Lys Ser Thr Ser Gly Gly 115 120 125 Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 130 135 140 Thr Val Ser Trp
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 145 150 155 160 Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 165 170
175 Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
180 185 190 Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu
Pro Lys 195 200 205 Ser Cys Asp Lys Thr His 210 <210> SEQ ID
NO 150 <211> LENGTH: 218 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 150 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val
Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln
Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln
Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala
Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu
Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu
Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105
110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu
Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu
Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys 210 215 <210> SEQ ID NO 151
<211> LENGTH: 801 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 151 Gln
Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10
15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr
20 25 30 Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu
Trp Ile 35 40 45 Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr
Asn Gly Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu
Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Ala Ser
Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Arg Glu Thr Thr
Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 145
150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr
Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His Lys Pro Ser Asn Thr
Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys Ser Cys Asp Lys Thr
His Thr Cys Pro Pro Cys Pro Ala Pro Glu 225 230 235 240 Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 245 250 255 Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 260 265
270 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
275 280 285 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
Tyr Ser 290 295 300 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
His Gln Asp Trp 305 310 315 320 Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys Ala Leu Pro 325 330 335 Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly Gln Pro Arg Glu 340 345 350 Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 355 360 365 Gln Val Ser
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 370 375 380 Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 385 390
395 400 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
Lys 405 410 415 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser Cys 420 425 430 Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr Gln Lys Ser Leu 435 440 445 Ser Leu Ser Pro Gly Gly Gly Gly Gly
Ser Gly Gly Gly Gly Ser Gly 450 455 460 Gly Gly Gly Ser Gly Gln Pro
Arg Glu Pro Gln Val Tyr Thr Leu Pro 465 470 475 480 Pro Ser Arg Glu
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 485 490 495 Val Lys
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 500 505 510
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 515
520 525 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
Arg 530 535 540 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
Glu Ala Leu 545 550 555 560 His Asn His Tyr Thr Gln Lys Ser Leu Ser
Leu Ser Pro Gly Ser Thr 565 570 575 Gly Ser Glu Val Gln Leu Gln Gln
Ser Gly Pro Glu Leu Val Lys Pro 580 585 590 Gly Ala Ser Val Lys Ile
Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 595 600 605 Glu Tyr Thr Met
His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu 610 615 620 Trp Ile
Gly Gly Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr Asn Gln 625 630 635
640 Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr
645 650 655 Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala
Val Tyr 660 665 670 Tyr Cys Ala Arg Arg Gly Gly Ser Phe Asp Tyr Trp
Gly Gln Gly Thr 675 680 685 Thr Leu Thr Val Ser Ser Arg Thr Val Ala
Ala Pro Ser Val Phe Ile
690 695 700 Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
Val Val 705 710 715 720 Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
Lys Val Gln Trp Lys 725 730 735 Val Asp Asn Ala Leu Gln Ser Gly Asn
Ser Gln Glu Ser Val Thr Glu 740 745 750 Gln Asp Ser Lys Asp Ser Thr
Tyr Ser Leu Ser Ser Thr Leu Thr Leu 755 760 765 Ser Lys Ala Asp Tyr
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 770 775 780 His Gln Gly
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 785 790 795 800
Cys <210> SEQ ID NO 152 <211> LENGTH: 214 <212>
TYPE: PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 152 Asp Ile Val Met Thr Gln Ser Pro Ala Thr
Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser Cys Arg
Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr Gln Gln
Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser
Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly
Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 65 70 75 80
Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 85
90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala Ser Thr Lys
Gly 100 105 110 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
Ser Gly Gly 115 120 125 Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro Glu Pro Val 130 135 140 Thr Val Ser Trp Asn Ser Gly Ala Leu
Thr Ser Gly Val His Thr Phe 145 150 155 160 Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 165 170 175 Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 180 185 190 Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 195 200 205
Ser Cys Asp Lys Thr His 210 <210> SEQ ID NO 153 <211>
LENGTH: 218 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 153 Asp Ile Gln Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala
Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly
Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40
45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro
50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn
Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys
Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe
Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170
175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215
<210> SEQ ID NO 154 <211> LENGTH: 796 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 154 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp
Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85
90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210
215 220 Lys Ser Cys Gly Gly Gly Ser Ser Ala Pro Glu Leu Leu Gly Gly
Pro 225 230 235 240 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
Leu Met Ile Ser 245 250 255 Arg Thr Pro Glu Val Thr Cys Val Val Val
Asp Val Ser His Glu Asp 260 265 270 Pro Glu Val Lys Phe Asn Trp Tyr
Val Asp Gly Val Glu Val His Asn 275 280 285 Ala Lys Thr Lys Pro Arg
Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val 290 295 300 Val Ser Val Leu
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 305 310 315 320 Tyr
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 325 330
335 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
340 345 350 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
Leu Thr 355 360 365 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu 370 375 380 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
Thr Thr Pro Pro Val Leu 385 390 395 400 Asp Ser Asp Gly Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys 405 410 415 Ser Arg Trp Gln Gln
Gly Asn Val Phe Ser Cys Ser Val Met His Glu 420 425 430 Ala Leu His
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 Gly
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 450 455
460 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
465 470 475 480 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr 485 490 495 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
Gly Gln Pro Glu Asn 500 505 510 Asn Tyr Lys Thr Thr Pro Pro Val Leu
Asp Ser Asp Gly Ser Phe Phe 515 520 525 Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly Asn 530 535 540 Val Phe Ser Cys Ser
Val Met His Glu Ala Leu His Asn His Tyr Thr 545 550 555 560 Gln Lys
Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser Glu Val Gln 565 570 575
Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys 580
585 590 Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met
His 595 600 605 Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
Gly Gly Ile 610 615 620
Ser Pro Asn Ile Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys 625
630 635 640 Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met
Glu Leu 645 650 655 Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr
Cys Ala Arg Arg 660 665 670 Gly Gly Ser Phe Asp Tyr Trp Gly Gln Gly
Thr Thr Leu Thr Val Ser 675 680 685 Ser Arg Thr Val Ala Ala Pro Ser
Val Phe Ile Phe Pro Pro Ser Asp 690 695 700 Glu Gln Leu Lys Ser Gly
Thr Ala Ser Val Val Cys Leu Leu Asn Asn 705 710 715 720 Phe Tyr Pro
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 725 730 735 Gln
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 740 745
750 Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
755 760 765 Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
Leu Ser 770 775 780 Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
785 790 795 <210> SEQ ID NO 155 <211> LENGTH: 214
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 155 Asp Ile Val Met Thr Gln Ser Pro
Ala Thr Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser
Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr
Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr
Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 65
70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe
Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala
Ser Thr Lys Gly 100 105 110 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly Gly 115 120 125 Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro Val 130 135 140 Thr Val Ser Trp Asn Ser
Gly Ala Leu Thr Ser Gly Val His Thr Phe 145 150 155 160 Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 165 170 175 Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 180 185
190 Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys
195 200 205 Ser Cys Asp Lys Thr His 210 <210> SEQ ID NO 156
<211> LENGTH: 218 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 156 Asp
Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10
15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp
20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln
Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser
Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala
Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe
Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145
150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His
Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly
Glu Cys 210 215 <210> SEQ ID NO 157 <211> LENGTH: 819
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 157 Gln Val Gln Leu Gln Gln Ser Gly
Ala Glu Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys
Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp
Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln
Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65
70 75 80 Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr
Phe Cys 85 90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr
Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val
Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala
Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185
190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
195 200 205 Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val
Glu Pro 210 215 220 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
Pro Ala Pro Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310
315 320 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro 325 330 335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu 340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
Glu Met Thr Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435
440 445 Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly 450 455 460 Gly Gly Gly Ser Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro 465 470 475 480 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu 485 490 495 Val Lys Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn 500 505 510 Gly Gln Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 515 520 525 Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 530 535 540 Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
545 550 555 560 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Ser Thr 565 570 575 Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro
Glu Leu Val Lys Pro 580 585 590 Gly Ala Ser Val Lys Ile Ser Cys Lys
Thr Ser Gly Tyr Thr Phe Thr 595 600 605 Glu Tyr Thr Met His Trp Val
Lys Gln Ser His Gly Lys Ser Leu Glu 610 615 620 Trp Ile Gly Gly Ile
Ser Pro Asn Ile Gly Gly Thr Ser Tyr Asn Gln 625 630 635 640 Lys Phe
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 645 650 655
Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 660
665 670 Tyr Cys Ala Arg Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln Gly
Thr 675 680 685 Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly
Ser Gly Gly 690 695 700 Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Val
Met Thr Gln Ser Pro 705 710 715 720 Ala Thr Leu Ser Val Thr Pro Gly
Asp Arg Val Ser Leu Ser Cys Arg 725 730 735 Ala Ser Gln Ser Ile Ser
Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser 740 745 750 His Glu Ser Pro
Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser 755 760 765 Gly Ile
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr 770 775 780
Leu Ser Ile Asn Ser Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys 785
790 795 800 Gln Asn Gly His Ser Phe Pro Leu Thr Phe Gly Ala Gly Thr
Lys Leu 805 810 815 Glu Leu Lys <210> SEQ ID NO 158
<211> LENGTH: 218 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 158 Asp
Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10
15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp
20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln
Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser
Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala
Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe
Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145
150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His
Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly
Glu Cys 210 215 <210> SEQ ID NO 159 <211> LENGTH: 819
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 159 Gln Val Gln Leu Gln Gln Ser Gly
Ala Glu Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys
Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp
Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln
Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65
70 75 80 Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr
Phe Cys 85 90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr
Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val
Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala
Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185
190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
195 200 205 Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val
Glu Pro 210 215 220 Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser
Pro Ala Pro Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310
315 320 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro 325 330 335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu 340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
Glu Met Thr Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435
440 445 Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly 450 455 460 Gly Gly Gly Ser Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro 465 470 475 480 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu 485 490 495 Val Lys Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn 500 505 510 Gly Gln Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 515 520 525 Asp Gly Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 530 535 540 Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 545 550 555
560 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Thr
565 570 575 Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val
Lys Pro 580 585 590 Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly
Tyr Thr Phe Thr 595 600 605 Glu Tyr Thr Met His Trp Val Lys Gln Ser
His Gly Lys Ser Leu Glu 610 615 620 Trp Ile Gly Gly Ile Ser Pro Asn
Ile Gly Gly Thr Ser Tyr Asn Gln 625 630 635 640 Lys Phe Lys Gly Lys
Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 645 650 655 Ala Tyr Met
Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 660 665 670 Tyr
Cys Ala Arg Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 675 680
685 Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly
690 695 700 Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Val Met Thr Gln
Ser Pro 705 710 715 720 Ala Thr Leu Ser Val Thr Pro Gly Asp Arg Val
Ser Leu Ser Cys Arg 725 730 735
Ala Ser Gln Ser Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser 740
745 750 His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile
Ser 755 760 765 Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser
Asp Phe Thr 770 775 780 Leu Ser Ile Asn Ser Val Glu Pro Glu Asp Val
Gly Val Tyr Tyr Cys 785 790 795 800 Gln Asn Gly His Ser Phe Pro Leu
Thr Phe Gly Ala Gly Thr Lys Leu 805 810 815 Glu Leu Lys <210>
SEQ ID NO 160 <211> LENGTH: 218 <212> TYPE: PRT
<213> ORGANISM: Artificial <220> FEATURE: <223>
OTHER INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 160 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val
Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln
Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln
Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala
Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu
Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu
Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105
110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu
Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu
Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys 210 215 <210> SEQ ID NO 161
<211> LENGTH: 815 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 161 Gln
Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10
15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr
20 25 30 Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu
Trp Ile 35 40 45 Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr
Asn Gly Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu
Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Ala Ser
Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Arg Glu Thr Thr
Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 145
150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr
Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His Lys Pro Ser Asn Thr
Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys Ser Cys Gly Gly Gly
Ser Ser Pro Ala Pro Glu Leu Leu Gly Gly 225 230 235 240 Pro Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265
270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr
Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 355 360 365 Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390
395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro 435 440 445 Gly Gly Gly Gly Gly Ser Gly Gly Gly
Gly Ser Gly Gly Gly Gly Ser 450 455 460 Gly Gln Pro Arg Glu Pro Gln
Val Tyr Thr Leu Pro Pro Ser Arg Glu 465 470 475 480 Glu Met Thr Lys
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 485 490 495 Tyr Pro
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 500 505 510
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 515
520 525 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
Gly 530 535 540 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
Asn His Tyr 545 550 555 560 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
Ser Thr Gly Ser Glu Val 565 570 575 Gln Leu Gln Gln Ser Gly Pro Glu
Leu Val Lys Pro Gly Ala Ser Val 580 585 590 Lys Ile Ser Cys Lys Thr
Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met 595 600 605 His Trp Val Lys
Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly 610 615 620 Ile Ser
Pro Asn Ile Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly 625 630 635
640 Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu
645 650 655 Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
Ala Arg 660 665 670 Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr
Thr Leu Thr Val 675 680 685 Ser Ser Val Glu Gly Gly Ser Gly Gly Ser
Gly Gly Ser Gly Gly Ser 690 695 700 Gly Gly Val Asp Asp Ile Val Met
Thr Gln Ser Pro Ala Thr Leu Ser 705 710 715 720 Val Thr Pro Gly Asp
Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser 725 730 735 Ile Ser Asp
Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro 740 745 750 Arg
Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser 755 760
765 Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn
770 775 780 Ser Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn
Gly His 785 790 795 800 Ser Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys
Leu Glu Leu Lys 805 810 815 <210> SEQ ID NO 162 <211>
LENGTH: 819 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 162 Asp Ile Gln Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala
Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly
Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40
45
Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50
55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile
His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln
Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys
Leu Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser
Gly Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu Gln Gln Ser Gly Ala
Glu Leu Val Arg Pro Gly Ser Ser Val 130 135 140 Lys Ile Ser Cys Lys
Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 145 150 155 160 Asn Trp
Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 165 170 175
Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180
185 190 Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met
Gln 195 200 205 Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe
Cys Ala Arg 210 215 220 Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr
Ala Met Asp Tyr Trp 225 230 235 240 Gly Gln Gly Thr Thr Val Thr Val
Ser Ser Gly Gly Gly Ser Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 275 280 285 Val Asp
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 290 295 300
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305
310 315 320 Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
His Gln 325 330 335 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
Ser Asn Lys Ala 340 345 350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
Lys Ala Lys Gly Gln Pro 355 360 365 Arg Glu Pro Gln Val Tyr Thr Leu
Pro Pro Ser Arg Glu Glu Met Thr 370 375 380 Lys Asn Gln Val Ser Leu
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 420 425
430 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
435 440 445 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
Gln Lys 450 455 460 Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser
Gly Gly Gly Gly 465 470 475 480 Ser Gly Gly Gly Gly Ser Gly Gln Pro
Arg Glu Pro Gln Val Tyr Thr 485 490 495 Leu Pro Pro Ser Arg Glu Glu
Met Thr Lys Asn Gln Val Ser Leu Thr 500 505 510 Cys Leu Val Lys Gly
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 515 520 525 Ser Asn Gly
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 530 535 540 Asp
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 545 550
555 560 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
Glu 565 570 575 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
Ser Pro Gly 580 585 590 Ser Thr Gly Ser Glu Val Gln Leu Gln Gln Ser
Gly Pro Glu Leu Val 595 600 605 Lys Pro Gly Ala Ser Val Lys Ile Ser
Cys Lys Thr Ser Gly Tyr Thr 610 615 620 Phe Thr Glu Tyr Thr Met His
Trp Val Lys Gln Ser His Gly Lys Ser 625 630 635 640 Leu Glu Trp Ile
Gly Gly Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr 645 650 655 Asn Gln
Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 660 665 670
Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 675
680 685 Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser Phe Asp Tyr Trp Gly
Gln 690 695 700 Gly Thr Thr Leu Thr Val Ser Ser Arg Thr Val Ala Ala
Pro Ser Val 705 710 715 720 Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu
Lys Ser Gly Thr Ala Ser 725 730 735 Val Val Cys Leu Leu Asn Asn Phe
Tyr Pro Arg Glu Ala Lys Val Gln 740 745 750 Trp Lys Val Asp Asn Ala
Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 755 760 765 Thr Glu Gln Asp
Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 770 775 780 Thr Leu
Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 785 790 795
800 Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg
805 810 815 Gly Glu Cys <210> SEQ ID NO 163 <211>
LENGTH: 214 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 163 Asp Ile Val Met Thr
Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val
Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu
His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40
45 Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val
Glu Pro 65 70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His
Ser Phe Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
Lys Ala Ser Thr Lys Gly 100 105 110 Pro Ser Val Phe Pro Leu Ala Pro
Ser Ser Lys Ser Thr Ser Gly Gly 115 120 125 Thr Ala Ala Leu Gly Cys
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 130 135 140 Thr Val Ser Trp
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 145 150 155 160 Pro
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 165 170
175 Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
180 185 190 Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu
Pro Lys 195 200 205 Ser Cys Asp Lys Thr His 210 <210> SEQ ID
NO 164 <211> LENGTH: 819 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 164 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val
Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln
Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln
Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala
Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu
Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu
Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 100 105
110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val
115 120 125 Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser
Ser Val 130 135 140 Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser
Ser Tyr Trp Met 145 150 155 160 Asn Trp Val Lys Gln Arg Pro Gly Gln
Gly Leu Glu Trp Ile Gly Gln 165 170 175 Ile Trp Pro Gly Asp Gly Asp
Thr Asn Tyr Asn Gly Lys Phe Lys Gly 180 185 190 Lys Ala Thr Leu Thr
Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205 Leu Ser Ser
Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 210 215 220
Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp 225
230 235 240 Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Ser
Ser Ala 245 250 255 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
Pro Pro Lys Pro 260 265 270 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu Val Thr Cys Val Val 275 280 285 Val Asp Val Ser His Glu Asp Pro
Glu Val Lys Phe Asn Trp Tyr Val 290 295 300 Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 305 310 315 320 Tyr Ser Ser
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 325 330 335 Asp
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 340 345
350 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
355 360 365 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
Met Thr 370 375 380 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
Phe Tyr Pro Ser 385 390 395 400 Asp Ile Ala Val Glu Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr 405 410 415 Lys Thr Thr Pro Pro Val Leu
Asp Ser Asp Gly Ser Phe Phe Leu Tyr 420 425 430 Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 435 440 445 Ser Cys Ser
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 450 455 460 Ser
Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 465 470
475 480 Ser Gly Gly Gly Gly Ser Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr 485 490 495 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
Ser Leu Thr 500 505 510 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu 515 520 525 Ser Asn Gly Gln Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu 530 535 540 Asp Ser Asp Gly Ser Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys 545 550 555 560 Ser Arg Trp Gln
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 565 570 575 Ala Leu
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 580 585 590
Ser Thr Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 595
600 605 Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr
Thr 610 615 620 Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln Ser His
Gly Lys Ser 625 630 635 640 Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn
Ile Gly Gly Thr Ser Tyr 645 650 655 Asn Gln Lys Phe Lys Gly Lys Ala
Thr Leu Thr Val Asp Lys Ser Ser 660 665 670 Ser Thr Ala Tyr Met Glu
Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 675 680 685 Val Tyr Tyr Cys
Ala Arg Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln 690 695 700 Gly Thr
Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 705 710 715
720 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
725 730 735 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
Val Ser 740 745 750 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
Phe Pro Ala Val 755 760 765 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
Ser Val Val Thr Val Pro 770 775 780 Ser Ser Ser Leu Gly Thr Gln Thr
Tyr Ile Cys Asn Val Asn His Lys 785 790 795 800 Pro Ser Asn Thr Lys
Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 805 810 815 Lys Thr His
<210> SEQ ID NO 165 <211> LENGTH: 214 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 165 Asp Ile Val Met Thr Gln Ser Pro Ala Thr
Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser Cys Arg
Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr Gln Gln
Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser
Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly
Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 65 70 75 80
Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 85
90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala
Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu
Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala
Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln
Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr
Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys
Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205
Phe Asn Arg Gly Glu Cys 210 <210> SEQ ID NO 166 <211>
LENGTH: 218 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 166 Asp Ile Gln Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala
Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly
Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40
45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro
50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn
Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys
Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe
Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170
175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215
<210> SEQ ID NO 167 <211> LENGTH: 792 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 167 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp
Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85
90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
Ser Thr Lys 115 120 125
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 130
135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
Pro 145 150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
Gly Val His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu
Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser Ser Ser Leu
Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His Lys Pro Ser
Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys Ser Cys Asp
Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu 225 230 235 240 Leu
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 245 250
255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
260 265 270 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
Asp Gly 275 280 285 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
Glu Gln Tyr Ser 290 295 300 Ser Thr Tyr Arg Val Val Ser Val Leu Thr
Val Leu His Gln Asp Trp 305 310 315 320 Leu Asn Gly Lys Glu Tyr Lys
Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330 335 Ala Pro Ile Glu Lys
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 340 345 350 Pro Gln Val
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 355 360 365 Gln
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 370 375
380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
385 390 395 400 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
Asn Val Phe Ser Cys 420 425 430 Ser Val Met His Glu Ala Leu His Asn
His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser Leu Ser Pro Gly Gly Gly
Gly Gly Ser Gly Gly Gly Gly Ser Gly 450 455 460 Gly Gly Gly Ser Gly
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 465 470 475 480 Pro Ser
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 485 490 495
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 500
505 510 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser 515 520 525 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
Lys Ser Arg 530 535 540 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
Met His Glu Ala Leu 545 550 555 560 His Asn His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Ser Thr 565 570 575 Gly Ser Asp Ile Val Met
Thr Gln Ser Pro Ala Thr Leu Ser Val Thr 580 585 590 Pro Gly Asp Arg
Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser 595 600 605 Asp Tyr
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu 610 615 620
Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe 625
630 635 640 Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn
Ser Val 645 650 655 Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn
Gly His Ser Phe 660 665 670 Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys Ala Ser Thr 675 680 685 Lys Gly Pro Ser Val Phe Pro Leu
Ala Pro Ser Ser Lys Ser Thr Ser 690 695 700 Gly Gly Thr Ala Ala Leu
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 705 710 715 720 Pro Val Thr
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 725 730 735 Thr
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 740 745
750 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
755 760 765 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg
Val Glu 770 775 780 Pro Lys Ser Cys Asp Lys Thr His 785 790
<210> SEQ ID NO 168 <211> LENGTH: 223 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 168 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu
Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Thr
Ser Gly Tyr Thr Phe Thr Glu Tyr 20 25 30 Thr Met His Trp Val Lys
Gln Ser His Gly Lys Ser Leu Glu Trp Ile 35 40 45 Gly Gly Ile Ser
Pro Asn Ile Gly Gly Thr Ser Tyr Asn Gln Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85
90 95 Ala Arg Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr
Leu 100 105 110 Thr Val Ser Ser Arg Thr Val Ala Ala Pro Ser Val Phe
Ile Phe Pro 115 120 125 Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala
Ser Val Val Cys Leu 130 135 140 Leu Asn Asn Phe Tyr Pro Arg Glu Ala
Lys Val Gln Trp Lys Val Asp 145 150 155 160 Asn Ala Leu Gln Ser Gly
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 165 170 175 Ser Lys Asp Ser
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 180 185 190 Ala Asp
Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 195 200 205
Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215
220 <210> SEQ ID NO 169 <211> LENGTH: 445 <212>
TYPE: PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 169 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser
Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys
Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn
Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile
Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80
Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85
90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu
Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys
Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys 210
215 220 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val Val Asp Val Ser His
Glu Asp Pro Glu Val Lys 260 265 270 Phe Asn Trp Tyr Val Asp Gly Val
Glu Val His Asn Ala Lys Thr Lys 275 280 285 Pro Arg Glu Glu Gln Tyr
Asn Ser Thr Tyr Arg Val Val Ser Val Leu 290 295 300 Thr Val Leu His
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 305 310 315 320 Val
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 325 330
335
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 340
345 350 Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
Lys 355 360 365 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
Asn Gly Gln 370 375 380 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
Leu Asp Ser Asp Gly 385 390 395 400 Ser Phe Phe Leu Tyr Ser Lys Leu
Thr Val Asp Lys Ser Arg Trp Gln 405 410 415 Gln Gly Asn Val Phe Ser
Cys Ser Val Met His Glu Ala Leu His Asn 420 425 430 His Tyr Thr Gln
Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> SEQ ID
NO 170 <211> LENGTH: 680 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 170 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys Gln Arg Pro
Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp Pro Gly Asp
Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly Lys Ala Thr
Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu
Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala
Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 100 105
110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys
115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala
Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser
Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 225 230
235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala Lys Thr Lys
Pro Arg Glu Glu Gln Tyr Asn 290 295 300 Ser Thr Tyr Arg Val Val Ser
Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu Asn Gly Lys
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330 335 Ala Pro
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 340 345 350
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 355
360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys Ser Arg Trp
Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met His Glu Ala
Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser Leu Ser Pro
Gly Ser Thr Gly Ser Glu Val Gln Leu Gln Gln Ser 450 455 460 Gly Pro
Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys 465 470 475
480 Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys Gln
485 490 495 Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro
Asn Ile 500 505 510 Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys
Ala Thr Leu Thr 515 520 525 Val Asp Lys Ser Ser Ser Thr Ala Tyr Met
Glu Leu Arg Ser Leu Thr 530 535 540 Ser Glu Asp Ser Ala Val Tyr Tyr
Cys Ala Arg Arg Gly Gly Ser Phe 545 550 555 560 Asp Tyr Trp Gly Gln
Gly Thr Thr Leu Thr Val Ser Ser Arg Thr Val 565 570 575 Ala Ala Pro
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 580 585 590 Ser
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 595 600
605 Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
610 615 620 Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
Tyr Ser 625 630 635 640 Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
Tyr Glu Lys His Lys 645 650 655 Val Tyr Ala Cys Glu Val Thr His Gln
Gly Leu Ser Ser Pro Val Thr 660 665 670 Lys Ser Phe Asn Arg Gly Glu
Cys 675 680 <210> SEQ ID NO 171 <211> LENGTH: 214
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 171 Asp Ile Val Met Thr Gln Ser Pro
Ala Thr Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser
Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr
Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr
Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60
Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 65
70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe
Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala
Ser Thr Lys Gly 100 105 110 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly Gly 115 120 125 Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro Val 130 135 140 Thr Val Ser Trp Asn Ser
Gly Ala Leu Thr Ser Gly Val His Thr Phe 145 150 155 160 Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 165 170 175 Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 180 185
190 Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys
195 200 205 Ser Cys Asp Lys Thr His 210 <210> SEQ ID NO 172
<211> LENGTH: 445 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 172 Asp
Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10
15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp
20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln
Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser
Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala
Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe
Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145
150 155 160
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165
170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu
Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp
Lys Thr His Thr Cys 210 215 220 Pro Pro Cys Pro Ala Pro Glu Leu Leu
Gly Gly Pro Ser Val Phe Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 245 250 255 Val Thr Cys Val
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 260 265 270 Phe Asn
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 275 280 285
Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu 290
295 300 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
Lys 305 310 315 320 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
Thr Ile Ser Lys 325 330 335 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
Tyr Thr Leu Pro Pro Ser 340 345 350 Arg Glu Glu Met Thr Lys Asn Gln
Val Ser Leu Thr Cys Leu Val Lys 355 360 365 Gly Phe Tyr Pro Ser Asp
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 370 375 380 Pro Glu Asn Asn
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 385 390 395 400 Ser
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 405 410
415 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
420 425 430 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435
440 445 <210> SEQ ID NO 173 <211> LENGTH: 680
<212> TYPE: PRT <213> ORGANISM: Artificial <220>
FEATURE: <223> OTHER INFORMATION: Chimeric homo sapiens mus
musculus <400> SEQUENCE: 173 Gln Val Gln Leu Gln Gln Ser Gly
Ala Glu Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys
Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp
Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln
Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65
70 75 80 Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr
Phe Cys 85 90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr
Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val
Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala
Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185
190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
195 200 205 Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val
Glu Pro 210 215 220 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
Pro Ala Pro Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu
Phe Pro Pro Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr
Pro Glu Val Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310
315 320 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
Pro 325 330 335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
Pro Arg Glu 340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
Glu Met Thr Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys
Gly Phe Tyr Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn
Gly Gln Pro Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435
440 445 Ser Leu Ser Pro Gly Ser Thr Gly Ser Glu Val Gln Leu Gln Gln
Ser 450 455 460 Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile
Ser Cys Lys 465 470 475 480 Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr
Met His Trp Val Lys Gln 485 490 495 Ser His Gly Lys Ser Leu Glu Trp
Ile Gly Gly Ile Ser Pro Asn Ile 500 505 510 Gly Gly Thr Ser Tyr Asn
Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 515 520 525 Val Asp Lys Ser
Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr 530 535 540 Ser Glu
Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser Phe 545 550 555
560 Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Arg Thr Val
565 570 575 Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
Leu Lys 580 585 590 Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
Phe Tyr Pro Arg 595 600 605 Glu Ala Lys Val Gln Trp Lys Val Asp Asn
Ala Leu Gln Ser Gly Asn 610 615 620 Ser Gln Glu Ser Val Thr Glu Gln
Asp Ser Lys Asp Ser Thr Tyr Ser 625 630 635 640 Leu Ser Ser Thr Leu
Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 645 650 655 Val Tyr Ala
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 660 665 670 Lys
Ser Phe Asn Arg Gly Glu Cys 675 680 <210> SEQ ID NO 174
<211> LENGTH: 214 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 174 Asp
Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 1 5 10
15 Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
20 25 30 Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu
Leu Ile 35 40 45 Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser
Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser
Ile Asn Ser Val Glu Pro 65 70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys
Gln Asn Gly His Ser Phe Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr
Lys Leu Glu Leu Lys Ala Ser Thr Lys Gly 100 105 110 Pro Ser Val Phe
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 115 120 125 Thr Ala
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 130 135 140
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 145
150 155 160 Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
Val Val 165 170 175 Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
Ile Cys Asn Val 180 185 190 Asn His Lys Pro Ser Asn Thr Lys Val Asp
Lys Arg Val Glu Pro Lys 195 200 205 Ser Cys Asp Lys Thr His 210
<210> SEQ ID NO 175 <211> LENGTH: 445 <212> TYPE:
PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 175 Asp Ile Gln Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala
Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly
Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40
45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro
50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn
Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys
Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe
Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170
175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Ser Asp Lys
Thr His Thr Cys 210 215 220 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu Val Lys 260 265 270 Phe Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 275 280 285 Pro
Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu 290 295
300 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305 310 315 320 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys 325 330 335 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser 340 345 350 Arg Glu Glu Met Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu Val Lys 355 360 365 Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn Gly Gln 370 375 380 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 385 390 395 400 Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 405 410 415
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 420
425 430 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440
445 <210> SEQ ID NO 176 <211> LENGTH: 680 <212>
TYPE: PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 176 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp
Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85
90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210
215 220 Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330
335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser
Leu Ser Pro Gly Ser Thr Gly Ser Glu Val Gln Leu Gln Gln Ser 450 455
460 Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
465 470 475 480 Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp
Val Lys Gln 485 490 495 Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly
Ile Ser Pro Asn Ile 500 505 510 Gly Gly Thr Ser Tyr Asn Gln Lys Phe
Lys Gly Lys Ala Thr Leu Thr 515 520 525 Val Asp Lys Ser Ser Ser Thr
Ala Tyr Met Glu Leu Arg Ser Leu Thr 530 535 540 Ser Glu Asp Ser Ala
Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser Phe 545 550 555 560 Asp Tyr
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Arg Thr Val 565 570 575
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 580
585 590 Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro
Arg 595 600 605 Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
Ser Gly Asn 610 615 620 Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys
Asp Ser Thr Tyr Ser 625 630 635 640 Leu Ser Ser Thr Leu Thr Leu Ser
Lys Ala Asp Tyr Glu Lys His Lys 645 650 655 Val Tyr Ala Cys Glu Val
Thr His Gln Gly Leu Ser Ser Pro Val Thr 660 665 670 Lys Ser Phe Asn
Arg Gly Glu Cys 675 680 <210> SEQ ID NO 177 <211>
LENGTH: 214 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 177 Asp Ile Val Met Thr
Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val
Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu
His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40
45 Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val
Glu Pro
65 70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe
Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala
Ser Thr Lys Gly 100 105 110 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly Gly 115 120 125 Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro Val 130 135 140 Thr Val Ser Trp Asn Ser
Gly Ala Leu Thr Ser Gly Val His Thr Phe 145 150 155 160 Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 165 170 175 Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 180 185
190 Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys
195 200 205 Ser Cys Asp Lys Thr His 210 <210> SEQ ID NO 178
<211> LENGTH: 445 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 178 Asp
Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10
15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp
20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln
Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser
Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala
Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe
Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145
150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His
Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly
Glu Cys Asp Lys Thr His Thr Cys 210 215 220 Pro Pro Cys Pro Ala Pro
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 225 230 235 240 Phe Pro Pro
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 245 250 255 Val
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 260 265
270 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
275 280 285 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
Val Leu 290 295 300 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
Tyr Lys Cys Lys 305 310 315 320 Val Ser Asn Lys Ala Leu Pro Ala Pro
Ile Glu Lys Thr Ile Ser Lys 325 330 335 Ala Lys Gly Gln Pro Arg Glu
Pro Gln Val Tyr Thr Leu Pro Pro Ser 340 345 350 Arg Glu Glu Met Thr
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 355 360 365 Gly Phe Tyr
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 370 375 380 Pro
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 385 390
395 400 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
Gln 405 410 415 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
Leu His Asn 420 425 430 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
Gly Lys 435 440 445 <210> SEQ ID NO 179 <211> LENGTH:
698 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 179 Gln Val Gln Leu Gln
Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys
Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp
Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40
45 Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr
Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala
Val Tyr Phe Cys 85 90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg
Tyr Tyr Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val
Thr Val Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170
175 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
180 185 190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
Cys Asn 195 200 205 Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
Arg Val Glu Pro 210 215 220 Lys Ser Cys Asp Lys Thr His Thr Cys Pro
Pro Cys Pro Ala Pro Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val
Phe Leu Phe Pro Pro Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 260 265 270 Val Ser His
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 290 295
300 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305 310 315 320 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
Ala Leu Pro 325 330 335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
Gly Gln Pro Arg Glu 340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser
Arg Glu Glu Met Thr Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu
Val Lys Gly Phe Tyr Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420
425 430 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
Leu 435 440 445 Ser Leu Ser Pro Gly Ser Thr Gly Ser Glu Val Gln Leu
Gln Gln Ser 450 455 460 Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val
Lys Ile Ser Cys Lys 465 470 475 480 Thr Ser Gly Tyr Thr Phe Thr Glu
Tyr Thr Met His Trp Val Lys Gln 485 490 495 Ser His Gly Lys Ser Leu
Glu Trp Ile Gly Gly Ile Ser Pro Asn Ile 500 505 510 Gly Gly Thr Ser
Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 515 520 525 Val Asp
Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr 530 535 540
Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser Phe 545
550 555 560 Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val
Glu Gly 565 570 575 Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly
Gly Val Asp Asp 580 585 590 Ile Val Met Thr Gln Ser Pro Ala Thr Leu
Ser Val Thr Pro Gly Asp 595 600 605 Arg Val Ser Leu Ser Cys Arg Ala
Ser Gln Ser Ile Ser Asp Tyr Leu 610 615 620 His Trp Tyr Gln Gln Lys
Ser His Glu Ser Pro Arg Leu Leu Ile Lys
625 630 635 640 Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe
Ser Gly Ser 645 650 655 Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn
Ser Val Glu Pro Glu 660 665 670 Asp Val Gly Val Tyr Tyr Cys Gln Asn
Gly His Ser Phe Pro Leu Thr 675 680 685 Phe Gly Ala Gly Thr Lys Leu
Glu Leu Lys 690 695 <210> SEQ ID NO 180 <211> LENGTH:
445 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 180 Asp Ile Gln Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala
Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly
Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40
45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro
50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn
Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys
Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe
Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170
175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys
Thr His Thr Cys 210 215 220 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu Val Lys 260 265 270 Phe Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 275 280 285 Pro
Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu 290 295
300 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305 310 315 320 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
Ile Ser Lys 325 330 335 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
Thr Leu Pro Pro Ser 340 345 350 Arg Glu Glu Met Thr Lys Asn Gln Val
Ser Leu Thr Cys Leu Val Lys 355 360 365 Gly Phe Tyr Pro Ser Asp Ile
Ala Val Glu Trp Glu Ser Asn Gly Gln 370 375 380 Pro Glu Asn Asn Tyr
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 385 390 395 400 Ser Phe
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 405 410 415
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 420
425 430 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440
445 <210> SEQ ID NO 181 <211> LENGTH: 698 <212>
TYPE: PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 181 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp
Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85
90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210
215 220 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330
335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser
Leu Ser Pro Gly Ser Thr Gly Ser Glu Val Gln Leu Gln Gln Ser 450 455
460 Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
465 470 475 480 Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp
Val Lys Gln 485 490 495 Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly
Ile Ser Pro Asn Ile 500 505 510 Gly Gly Thr Ser Tyr Asn Gln Lys Phe
Lys Gly Lys Ala Thr Leu Thr 515 520 525 Val Asp Lys Ser Ser Ser Thr
Ala Tyr Met Glu Leu Arg Ser Leu Thr 530 535 540 Ser Glu Asp Ser Ala
Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser Phe 545 550 555 560 Asp Tyr
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val Glu Gly 565 570 575
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp 580
585 590 Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly
Asp 595 600 605 Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser
Asp Tyr Leu 610 615 620 His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro
Arg Leu Leu Ile Lys 625 630 635 640 Tyr Ala Ser Gln Ser Ile Ser Gly
Ile Pro Ser Arg Phe Ser Gly Ser 645 650 655 Gly Ser Gly Ser Asp Phe
Thr Leu Ser Ile Asn Ser Val Glu Pro Glu 660 665 670 Asp Val Gly Val
Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu Thr 675 680 685 Phe Gly
Ala Gly Thr Lys Leu Glu Leu Lys 690 695
<210> SEQ ID NO 182 <211> LENGTH: 454 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 182 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala
Ser Gly Tyr Ala Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Lys
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gln Ile Trp
Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 50 55 60 Lys Gly
Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 65 70 75 80
Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 85
90 95 Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met
Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val
Lys Asp Tyr Phe Pro Glu Pro 145 150 155 160 Val Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210
215 220 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val
Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val
Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser 290 295 300 Ser Thr Tyr Arg
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330
335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
Pro Ser Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser
Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser
Leu Ser Pro Gly Lys 450 <210> SEQ ID NO 183 <211>
LENGTH: 670 <212> TYPE: PRT <213> ORGANISM: Artificial
<220> FEATURE: <223> OTHER INFORMATION: Chimeric homo
sapiens mus musculus <400> SEQUENCE: 183 Asp Ile Gln Leu Thr
Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala
Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 20 25 30 Gly
Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 35 40
45 Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro
50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn
Ile His 65 70 75 80 Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys
Gln Gln Ser Thr 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr
Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe
Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170
175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys
Thr His Thr Cys 210 215 220 Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
Gly Pro Ser Val Phe Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp
Thr Leu Met Ile Ser Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val
Val Asp Val Ser His Glu Asp Pro Glu Val Lys 260 265 270 Phe Asn Trp
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 275 280 285 Pro
Arg Glu Glu Gln Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr 290 295
300 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
305 310 315 320 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala 325 330 335 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg 340 345 350 Glu Glu Met Thr Lys Asn Gln Val Ser
Leu Thr Cys Leu Val Lys Gly 355 360 365 Phe Tyr Pro Ser Asp Ile Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro 370 375 380 Glu Asn Asn Tyr Lys
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 385 390 395 400 Phe Phe
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 405 410 415
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 420
425 430 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Thr Gly Ser
Glu 435 440 445 Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro
Gly Ala Ser 450 455 460 Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr
Phe Thr Glu Tyr Thr 465 470 475 480 Met His Trp Val Lys Gln Ser His
Gly Lys Ser Leu Glu Trp Ile Gly 485 490 495 Gly Ile Ser Pro Asn Ile
Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 500 505 510 Gly Lys Ala Thr
Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 515 520 525 Glu Leu
Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 530 535 540
Arg Arg Gly Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 545
550 555 560 Val Ser Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe
Pro Pro 565 570 575 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val
Val Cys Leu Leu 580 585 590 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
Gln Trp Lys Val Asp Asn 595 600 605 Ala Leu Gln Ser Gly Asn Ser Gln
Glu Ser Val Thr Glu Gln Asp Ser 610 615 620 Lys Asp Ser Thr Tyr Ser
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 625 630 635 640 Asp Tyr Glu
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 645 650 655 Leu
Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 660 665 670
<210> SEQ ID NO 184 <211> LENGTH: 214 <212> TYPE:
PRT <213> ORGANISM: Artificial <220> FEATURE:
<223> OTHER INFORMATION: Chimeric homo sapiens mus musculus
<400> SEQUENCE: 184 Asp Ile Val Met Thr Gln Ser Pro Ala Thr
Leu Ser Val Thr Pro Gly 1 5 10 15 Asp Arg Val Ser Leu Ser Cys Arg
Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu His Trp Tyr Gln Gln
Lys Ser His Glu Ser Pro Arg Leu Leu Ile 35 40 45
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50
55 60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu
Pro 65 70 75 80 Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser
Phe Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
Ala Ser Thr Lys Gly 100 105 110 Pro Ser Val Phe Pro Leu Ala Pro Ser
Ser Lys Ser Thr Ser Gly Gly 115 120 125 Thr Ala Ala Leu Gly Cys Leu
Val Lys Asp Tyr Phe Pro Glu Pro Val 130 135 140 Thr Val Ser Trp Asn
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 145 150 155 160 Pro Ala
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 165 170 175
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 180
185 190 Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro
Lys 195 200 205 Ser Cys Asp Lys Thr His 210 <210> SEQ ID NO
185 <211> LENGTH: 445 <212> TYPE: PRT <213>
ORGANISM: Artificial <220> FEATURE: <223> OTHER
INFORMATION: Chimeric homo sapiens mus musculus <400>
SEQUENCE: 185 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val
Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln
Ser Val Asp Tyr Asp 20 25 30 Gly Asp Ser Tyr Leu Asn Trp Tyr Gln
Gln Ile Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Asp Ala
Ser Asn Leu Val Ser Gly Ile Pro Pro 50 55 60 Arg Phe Ser Gly Ser
Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu
Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 85 90 95 Glu
Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105
110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu
Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu
Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr Cys 210 215 220 Pro
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 225 230
235 240 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
Glu 245 250 255 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
Glu Val Lys 260 265 270 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
Asn Ala Lys Thr Lys 275 280 285 Pro Arg Glu Glu Gln Tyr Ser Ser Thr
Tyr Arg Val Val Ser Val Leu 290 295 300 Thr Val Leu His Gln Asp Trp
Leu Asn Gly Lys Glu Tyr Lys Cys Lys 305 310 315 320 Val Ser Asn Lys
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 325 330 335 Ala Lys
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 340 345 350
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 355
360 365 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
Gln 370 375 380 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
Ser Asp Gly 385 390 395 400 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
Asp Lys Ser Arg Trp Gln 405 410 415 Gln Gly Asn Val Phe Ser Cys Ser
Val Met His Glu Ala Leu His Asn 420 425 430 His Tyr Thr Gln Lys Ser
Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> SEQ ID NO 186
<211> LENGTH: 671 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 186 Gln
Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10
15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr
20 25 30 Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu
Trp Ile 35 40 45 Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr
Asn Gly Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu
Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Ala Ser
Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Arg Glu Thr Thr
Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 100 105 110 Tyr Trp Gly Gln
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 145
150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr
Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His Lys Pro Ser Asn Thr
Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys Ser Cys Asp Lys Thr
His Thr Cys Pro Pro Cys Pro Ala Pro Glu 225 230 235 240 Leu Leu Gly
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 245 250 255 Thr
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 260 265
270 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
275 280 285 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
Tyr Ser 290 295 300 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
His Gln Asp Trp 305 310 315 320 Leu Asn Gly Lys Glu Tyr Lys Cys Lys
Val Ser Asn Lys Ala Leu Pro 325 330 335 Ala Pro Ile Glu Lys Thr Ile
Ser Lys Ala Lys Gly Gln Pro Arg Glu 340 345 350 Pro Gln Val Tyr Thr
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 355 360 365 Gln Val Ser
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 370 375 380 Ala
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 385 390
395 400 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
Lys 405 410 415 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
Phe Ser Cys 420 425 430 Ser Val Met His Glu Ala Leu His Asn His Tyr
Thr Gln Lys Ser Leu 435 440 445 Ser Leu Ser Pro Gly Ser Thr Gly Ser
Asp Ile Val Met Thr Gln Ser 450 455 460 Pro Ala Thr Leu Ser Val Thr
Pro Gly Asp Arg Val Ser Leu Ser Cys 465 470 475 480 Arg Ala Ser Gln
Ser Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys 485 490 495 Ser His
Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile 500 505 510
Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe 515
520 525 Thr Leu Ser Ile Asn Ser Val Glu Pro Glu Asp Val Gly Val Tyr
Tyr 530 535 540 Cys Gln Asn Gly His Ser Phe Pro Leu Thr Phe Gly Ala
Gly Thr Lys 545 550 555 560 Leu Glu Leu Lys Ala Ser Thr Lys Gly Pro
Ser Val Phe Pro Leu Ala 565 570 575 Pro Ser Ser Lys Ser Thr Ser Gly
Gly Thr Ala Ala Leu Gly Cys Leu 580 585 590 Val Lys Asp Tyr Phe Pro
Glu Pro Val Thr Val Ser Trp Asn Ser Gly 595 600 605
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 610
615 620 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
Leu 625 630 635 640 Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
Pro Ser Asn Thr 645 650 655 Lys Val Asp Lys Arg Val Glu Pro Lys Ser
Cys Asp Lys Thr His 660 665 670 <210> SEQ ID NO 187
<211> LENGTH: 223 <212> TYPE: PRT <213> ORGANISM:
Artificial <220> FEATURE: <223> OTHER INFORMATION:
Chimeric homo sapiens mus musculus <400> SEQUENCE: 187 Glu
Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 1 5 10
15 Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr
20 25 30 Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu
Trp Ile 35 40 45 Gly Gly Ile Ser Pro Asn Ile Gly Gly Thr Ser Tyr
Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys
Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Thr Ser
Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Arg Gly Gly Ser
Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 100 105 110 Thr Val Ser Ser
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 115 120 125 Pro Ser
Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 130 135 140
Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 145
150 155 160 Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu
Gln Asp 165 170 175 Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu
Thr Leu Ser Lys 180 185 190 Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
Cys Glu Val Thr His Gln 195 200 205 Gly Leu Ser Ser Pro Val Thr Lys
Ser Phe Asn Arg Gly Glu Cys 210 215 220
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