U.S. patent application number 14/750420 was filed with the patent office on 2016-12-29 for sunscreen compositions having synergistic combination of uv filters.
The applicant listed for this patent is L'OREAL. Invention is credited to Anthony Diaz-Santana, Susan Halpern Chirch, Anil Shah.
Application Number | 20160374916 14/750420 |
Document ID | / |
Family ID | 57601334 |
Filed Date | 2016-12-29 |
United States Patent
Application |
20160374916 |
Kind Code |
A1 |
Halpern Chirch; Susan ; et
al. |
December 29, 2016 |
SUNSCREEN COMPOSITIONS HAVING SYNERGISTIC COMBINATION OF UV
FILTERS
Abstract
The disclosure relates to sunscreen compositions having a
synergistic combination of ultraviolet light (UV) filtering agents
that provide a high sun protection factor (SPF). Compositions
according to the disclosure have high SPF values without requiring
high total amounts of UV filtering agents. Furthermore, the
disclosure relates to methods of using the described compositions
for protecting keratinous substances such as skin and hair from UV
radiation.
Inventors: |
Halpern Chirch; Susan;
(Basking Ridge, NJ) ; Diaz-Santana; Anthony;
(Edison, NJ) ; Shah; Anil; (East Windsor,
NJ) |
|
Applicant: |
Name |
City |
State |
Country |
Type |
L'OREAL |
Paris |
|
FR |
|
|
Family ID: |
57601334 |
Appl. No.: |
14/750420 |
Filed: |
June 25, 2015 |
Current U.S.
Class: |
424/60 |
Current CPC
Class: |
A61K 8/4966 20130101;
A61K 2800/262 20130101; A61K 8/41 20130101; A61K 8/37 20130101;
A61Q 17/04 20130101; A61K 8/35 20130101; A61K 8/466 20130101; A61K
2800/592 20130101; A61K 8/585 20130101; A61K 8/40 20130101; A61K
2800/5922 20130101 |
International
Class: |
A61K 8/58 20060101
A61K008/58; A61K 8/49 20060101 A61K008/49; A61Q 17/04 20060101
A61Q017/04; A61K 8/41 20060101 A61K008/41; A61K 8/46 20060101
A61K008/46; A61K 8/35 20060101 A61K008/35; A61K 8/37 20060101
A61K008/37 |
Claims
1. A sunscreen composition comprising a combination of the
following UV filters: butyl methoxydibenzoylmethane, ethylhexyl
triazone, drometrizole trisiloxane, homosalate, ethylhexyl
salicylate, octocrylene, and terephthalylidene dicamphor sulfonic
acid, wherein the ratio of each UV filter relative to butyl
methoxydibenzoylmethane is as follows: the ratio of ethylhexyl
triazone to butyl methoxydibenzoylmethane is 0.67:1.0 to 1.14:1.0;
the ratio of drometrizole trisiloxane to butyl
methoxydibenzoylmethane is 0:1.0 to 0.57:1.0; The ratio of
homosalate to butyl methoxydibenzoylmethane is 0.33:1.0 to
0.71:1.0; the ratio of ethylhexyl salicylate to butyl
methoxydibenzoylmethane is 0.33:1.0 to 0.71:1.0; the ratio of
octocrylene to butyl methoxydibenzoylmethane is 0.89:1.0 to
1.43:1.0; and the ratio of terephthalylidene dicamphor sulfonic
acid to butyl methoxydibenzoylmethane is 0:1.0 to 0.086:1.0.
2. The sunscreen composition according to claim 1, wherein the
total amount of the combination of UV filters is at least 1 wt. %
but not more than 35 wt. %, based on the total weight of the
sunscreen composition.
3. The sunscreen composition according to claim 2, wherein none of
the individual UV filters of the combination are present in an
amount greater than 5 wt. %.
4. The sunscreen composition according to claim 1 comprising: not
more than 5 wt. % butyl methoxydibenzoylmethane; not more than 4
wt. % ethylhexyl triazone; not more than 2 wt. % drometrizole
trisiloxane; not more than 3 wt. % homosalate; not more than 3 wt.
% ethylhexyl salicylate; not more than 5 wt. % octocrylene; and not
more than 1 wt. % terephthalylidene dicamphor sulfonic acid.
5. The sunscreen composition according to claim 1, wherein the
ratio of each filter relative to butyl methoxydibenzoylmethane is
about 1.0:0.9:0.4:0.7:0.5:1.1:0.1 (butyl
methoxydibenzoylmethane:ethylhexyl triazone:drometrizole
trisiloxane:homosalate:ethylhexyl
salicylate:octocrylene:terephthalylidene dicamphor sulfonic
acid).
6. The sunscreen composition according to claim 1 having an in
vitro SPF of at least 15.
7. The sunscreen composition according to claim 1 having an in
vitro SPF of at least 30.
8. The sunscreen composition according to claim 1 having an in
vitro SPF of at least 50.
9. The sunscreen composition according to claim 1 having an in
vitro SPF of at least 75.
10. The sunscreen composition according to claim 1 having an in
vitro SPF of at least 100.
11. The sunscreen composition according to claim 1, further
comprising a booster.
12. A clear sunscreen composition according to claim 1.
13. A spray-on sunscreen composition according to claim 1.
14. A sunscreen composition comprising: 3.5 to 4.5 wt. % butyl
methoxydibenzoylmethane; 3.0 to 4.0 wt. % ethylhexyl triazone; 0 to
2.0 wt. % drometrizole trisiloxane; 1.5 to 2.5 wt. % homosalate;
1.5 to 2.5 wt. % ethylhexyl salicylate; 4.0 to 5.0 wt. %
octocrylene; and 0 to 0.6 wt. % terephthalylidene dicamphor
sulfonic acid, wherein the weight percent in each case is based on
the total weight of the sunscreen composition.
15. A sunscreen composition according to claim 14 comprising: about
3.8 wt. % butyl methoxydibenzoylmethane; about 3.4 wt. % ethylhexyl
triazone; about 1.4 wt. % drometrizole trisiloxane; about 2.5 wt. %
homosalate; about 1.8 wt. % ethylhexyl salicylate; about 4.2 wt. %
octocrylene; and about 0.3 wt. % terephthalylidene dicamphor
sulfonic acid.
16. A clear, spray-on sunscreen composition according to claim
14.
17. The sunscreen composition according to claim 14, wherein the in
vitro SPF of the composition is a value that is at least 20 times
the value of the total weight percent of all UV filters in the
sunscreen composition.
18. The sunscreen composition according to claim 14, further
comprising a booster.
19. A method of protecting a keratinous substrate from ultraviolet
radiation comprising applying a sunscreen composition according to
claim 1 to the keratinous substrate.
20. A method of protecting a keratinous substrate from ultraviolet
radiation comprising applying a sunscreen composition according to
claim 15 to the keratinous substrate.
Description
FIELD OF THE DISCLOSURE
[0001] The present disclosure relates to sunscreen compositions
comprising a synergistic combination of ultra violet ("UV")
filters, and to methods of using the combination of UV filters to
protect keratinous substrates such as skin and hair from UV
radiation.
BACKGROUND
[0002] The negative effects of exposure to ultraviolet ("UV") light
are well-known. Prolonged exposure to sunlight causes damage such
as sunburn to the skin and dries out hair making it brittle. When
skin is exposed to UV light having a wavelength of from about 290
nm to about 400 nm, long term damage can lead to serious conditions
such as skin cancer.
[0003] UV light also contributes to aging by causing free radicals
to form in the skin. Free radicals include, for example, singlet
oxygen, hydroxyl radical, the superoxide anion, nitric oxide and
hydrogen radicals. Free radicals attack DNA, membrane lipids and
proteins, generating carbon radicals. These in turn react with
oxygen to produce a peroxyl radical that can attack adjacent fatty
acids to generate new carbon radicals. This cascade leads to a
chain reaction producing lipid peroxidation products. Damage to the
cell membrane results in loss of cell permeability, increased
intercellular ionic concentration, and decreased ability to excrete
or detoxify waste products. The end result is a loss of skin
elasticity and the appearance of wrinkles. This process is commonly
referred to as photo-aging.
[0004] Sunscreens can be used to protect against UV damage and
delay the signs of aging. The degree of UV protection afforded by a
sunscreen composition is directly related to the amount and type of
UV filters contained therein. The higher the amount of UV filters,
the greater the degree of UV protection. Nevertheless, it is
desirable to achieve the best photo protection efficacy with the
lowest amount of UV filters. The inventors of the instant
disclosure discovered ways to attain SPFs that were not previously
attainable with such low amounts of overall UV filters.
SUMMARY OF THE INVENTION
[0005] The present disclosure relates to sunscreen compositions
that have low amounts of UV filters yet excellent Sun Protection
Factors (SPF). Typically, the more UV filters included in a
sunscreen composition the higher the SPF. The inventors discovered
that when certain UV filters are combined in particular ratios,
they interact synergistically to exhibit a surprisingly effective
SPF. This allows for use of less total amounts of UV filters while
achieving sufficient SPF.
[0006] The present disclosure relates to a sunscreen composition
comprising a combination of the UV filters set forth in the table
below:
TABLE-US-00001 TECHNICAL INCI AND/OR IUPAC NAME NAME Butyl
Methoxydibenzoylmethane (INCI) Avobenzone Ethylhexyl Triazone
(INCI) Uvinul T150 Drometrizole Trisiloxane Mexoryl XL Homosalate
(INCI) 3,3,5- Homosalate Trimethylcyclohexyl 2-hydroxybenzoate
(IUPAC) Ethylhexyl Salicylate (INCI) Octisalate Octocrylene (INCI)
Octocrylene Terephthalylidene Dicamphor Sulfonic acid (INCI)
Mexoryl SX* *Mexoryl SX is 33% terephthalylidene dicamphor sulfonic
acid.
[0007] The ratio of each filter relative to butyl
methoxydibenzoylmethane in the sunscreen compositions is typically
as follows: [0008] the ratio of ethylhexyl triazone to butyl
methoxydibenzoylmethane is 0.67:1.0 to 1.14:1.0; [0009] the ratio
of drometrizole trisiloxane to butyl methoxydibenzoylmethane is
0:1.0 to 0.57:1.0; [0010] The ratio of homosalate to butyl
methoxydibenzoylmethane is 0.33:1.0 to 0.71:1.0; [0011] the ratio
of ethylhexyl salicylate to butyl methoxydibenzoylmethane is
0.33:1.0 to 0.71:1.0; [0012] the ratio of octocrylene to butyl
methoxydibenzoylmethane is 0.89:1.0 to 1.43:1.0; and [0013] the
ratio of terephthalylidene dicamphor sulfonic acid to butyl
methoxydibenzoylmethane is 0:1.0 to 0.086:1.0.
[0014] In particular, the ratio of each filter relative to butyl
methoxydibenzoylmethane may be about 1.0:0.9:0.4:0.7:0.5:1.1:0.1
(butyl methoxydibenzoylmethane:ethylhexyl triazone:drometrizole
trisiloxane:homosalate: ethylhexyl salicylate:octocrylene:
terephthalylidene dicamphor sulfonic acid).
[0015] In one embodiment the UV filters can be separately, or in
addition to the ratios set forth above, present in the following
percentages by weight relative to the entire weight of the
sunscreen composition: [0016] 3.5 to 4.5 wt. % butyl
methoxydibenzoylmethane; [0017] 3.0 to 4.0 wt. % ethylhexyl
triazone; [0018] 0 to 2.0 wt. % drometrizole trisiloxane; [0019]
1.5 to 2.5 wt. % homosalate; [0020] 1.5 to 2.5 wt. % ethylhexyl
salicylate; [0021] 4.0 to 5.0 wt. % octocrylene; and [0022] 0 to
0.6 wt. % terephthalylidene dicamphor sulfonic acid.
[0023] In some instances, the UV filters are present in the
following percentages by weight relative to the entire weight of
the sunscreen composition: about 3.8 wt. % butyl
methoxydibenzoylmethane, about 3.4 wt. % ethylhexyl triazone, about
1.4 wt. % drometrizole trisiloxane, about 2.5 wt. % homosalate,
about 1.8 wt. % ethylhexyl salicylate, about 4.2 wt. % octocrylene,
and about 0.3 wt. % terephthalylidene dicamphor sulfonic acid.
[0024] The present disclosure is also directed to methods of
protecting a keratinous substrate from ultraviolet radiation,
methods of absorbing ultraviolet light, and method for preventing
sun damage and/or sun burn to a keratinous substrate such as skin
or hair. Such methods encompass applying a sunscreen composition to
a keratinous substrate (such as the skin or hair) and subjecting
the keratinous substrate to ultraviolet radiation.
DETAILED DESCRIPTION
[0025] Where the following terms are used in this specification,
they are used as defined below.
[0026] The terms "comprising," "having," and "including" are used
in their open, non-limiting sense.
[0027] The terms "a" and "the" are understood to encompass the
plural as well as the singular.
[0028] As used herein, the expression "at least one" means one or
more and thus includes individual components as well as
mixtures/combinations.
[0029] "Cosmetically acceptable" means that the item in question is
compatible with any keratinous substrate. For example,
"cosmetically acceptable carrier" means a carrier that is
compatible with any keratinous substrate.
[0030] A "physiologically acceptable medium" means a medium which
is not toxic and can be applied to the skin, lips, hair, scalp,
lashes, brows, nails or any other cutaneous region of the body. The
composition of the instant disclosure may especially constitute a
cosmetic or dermatological composition.
[0031] A "sunscreen composition" as used herein, is meant to
include a composition for topical application to sun-exposed areas
of the skin and/or hair of mammals, especially humans. Such a
composition may be generally classified as leave-on or rinse off,
and includes any product applied to a human body for also improving
appearance, cleansing, odor control or general aesthetics. The
composition of the present invention can be in the form of a
liquid, lotion, cream, foam, scrub, gel, soap bar or toner, or
applied with an implement or via a face mask, pad or patch.
Non-limiting examples of such sunscreen compositions include
leave-on skin lotions, creams, antiperspirants, deodorants,
lipsticks, foundations, mascara, sunless tanners and sunscreen
lotions and wash-off shampoos, conditioners, shower gels, toilet
bars. In some cases, the sunscreen composition is clear. Also, the
sunscreen composition may be a spray-on sunscreen composition.
[0032] The phrase "essentially free" refers to less than or equal
to 0.5, 0.1, 0.05 or 0.01 wt. %.
[0033] The phrase "stable emulsion" refers to a composition that
does not undergo phase separation up to a temperature of 45.degree.
C. for at least two weeks.
[0034] A "clear" composition refers to a composition that is
visually clear to the naked eye. For example, the compositions may
have a turbidity measurement of less than 30 NTU. Distilled water
has a turbidity of 1 NTU and whole milk diluted 1 part in 350 parts
of distilled water has a turbidity of 200 NTU.
[0035] As mentioned above, the present disclosure relates to a
sunscreen composition having a combination of the following UV
filters: butyl methoxydibenzoylmethane, ethylhexyl triazone,
drometrizole trisiloxane, homosalate, ethylhexyl salicylate,
octocrylene, and terephthalylidene dicamphor sulfonic acid, wherein
the ratio of each UV filter relative to butyl
methoxydibenzoylmethane is as follows:
[0036] The ratio of each filter relative to butyl
methoxydibenzoylmethane in the sunscreen compositions is typically
as follows: [0037] the ratio of ethylhexyl triazone to butyl
methoxydibenzoylmethane is 0.67:1.0 to 1.14:1.0; [0038] the ratio
of drometrizole trisiloxane to butyl methoxydibenzoylmethane is
0:1.0 to 0.57:1.0; [0039] The ratio of homosalate to butyl
methoxydibenzoylmethane is 0.33:1.0 to 0.71:1.0; [0040] the ratio
of ethylhexyl salicylate to butyl methoxydibenzoylmethane is
0.33:1.0 to 0.71:1.0; [0041] the ratio of octocrylene to butyl
methoxydibenzoylmethane is 0.89:1.0 to 1.43:1.0; and [0042] the
ratio of terephthalylidene dicamphor sulfonic acid to butyl
methoxydibenzoylmethane is 0:1.0 to 0.086:1.0.
[0043] As shown above the bottom range for the ratio of
drometrizole trisiloxane and terephthalylidene dicamphor sulfonic
acid to butyl methoxydibenzoylmethane is zero (indicating that the
UV filter is not present). In some cases one or both of these UV
filters may be present, and the bottom end for the ratios is
0.05:1.0 (drometrizole trisiloxane or terephthalylidene dicamphor
sulfonic acid:butyl methoxydibenzoylmethane).
[0044] Furthermore, the ratio of each filter relative to butyl
methoxydibenzoylmethane in the sunscreen compositions may be as
follows: [0045] the ratio of ethylhexyl triazone to butyl
methoxydibenzoylmethane is 0.67:1.0 to 1.14:1.0; [0046] the ratio
of drometrizole trisiloxane to butyl methoxydibenzoylmethane is
0.30:1.0 to 0.57:1.0; [0047] The ratio of homosalate to butyl
methoxydibenzoylmethane is 0.33:1.0 to 0.71:1.0; [0048] the ratio
of ethylhexyl salicylate to butyl methoxydibenzoylmethane is
0.33:1.0 to 0.71:1.0; [0049] the ratio of octocrylene to butyl
methoxydibenzoylmethane is 0.89:1.0 to 1.43:1.0; and [0050] the
ratio of terephthalylidene dicamphor sulfonic acid to butyl
methoxydibenzoylmethane is 0.050:1.0 to 0.086:1.0.
[0051] Moreover, the ratio of each filter relative to butyl
methoxydibenzoylmethane in the sunscreen compositions may be as
follows: [0052] the ratio of ethylhexyl triazone to butyl
methoxydibenzoylmethane is 0.85:1.0 to 0.94:1.0; [0053] the ratio
of drometrizole trisiloxane to butyl methoxydibenzoylmethane is
0.35:1.0 to 0.39:1.0; [0054] The ratio of homosalate to butyl
methoxydibenzoylmethane is 0.63:1.0 to 0.69:1.0; [0055] the ratio
of ethylhexyl salicylate to butyl methoxydibenzoylmethane is
0.45:1.0 to 0.50:1.0; [0056] the ratio of octocrylene to butyl
methoxydibenzoylmethane is 1.05:1.0 to 1.16:1.0; and [0057] the
ratio of terephthalylidene dicamphor sulfonic acid to butyl
methoxydibenzoylmethane is 0.075:1.0 to 0.083:1.0.
[0058] In particular, the ratio of each filter relative to butyl
methoxydibenzoylmethane may be about 1.0:0.9:0.4:0.7:0.5:1.1:0.1
(butyl methoxydibenzoylmethane:ethylhexyl triazone:drometrizole
trisiloxane:homosalate: ethylhexyl salicylate:octocrylene:
terephthalylidene dicamphor sulfonic acid).
[0059] In some instances, the total amount of the combination of UV
filters is at least 1 wt. % but not more than 40 wt. %, 35 wt. %,
30 wt. %, 25 wt. %, or 20 wt. % based on the total weight of the
sunscreen composition. Additionally, in some cases, none of the
individual UV filters of the combination are present in an amount
greater than 10 wt. %, 9 wt. %, 8 wt. %, 7 wt. %, 6 wt. %, or 5 wt.
%. For example, the sunscreen composition may comprise: [0060] not
more than 5 wt. % butyl methoxydibenzoylmethane; [0061] not more
than 4 wt. % ethylhexyl triazone; [0062] not more than 2 wt. %
drometrizole trisiloxane; [0063] not more than 3 wt. % homosalate;
[0064] not more than 3 wt. % ethylhexyl salicylate; [0065] not more
than 5 wt. % octocrylene; and [0066] not more than 1 wt. %
terephthalylidene dicamphor sulfonic acid.
[0067] In some instances, the UV filters can be separately, or in
addition to the ratios set forth above, present in the following
percentages by weight relative to the entire weight of the
sunscreen composition: [0068] 3.5 to 4.5 wt. % butyl
methoxydibenzoylmethane; [0069] 3.0 to 4.0 wt. % ethylhexyl
triazone; [0070] 0 to 2.0 wt. % drometrizole trisiloxane; [0071]
1.5 to 2.5 wt. % homosalate; [0072] 1.5 to 2.5 wt. % ethylhexyl
salicylate; [0073] 4.0 to 5.0 wt. % octocrylene; and [0074] 0 to
0.6 wt. % terephthalylidene dicamphor sulfonic acid.
[0075] As shown above, the drometrizole trisiloxane and the
terephthalylidene dicamphor sulfonic acid may not be present in the
sunscreen compositions. Alternatively, drometrizole trisiloxane may
be present in a positive amount, or from 1.0 wt. % to 2.0 wt. %.
Likewise, the terephthalylidene dicamphor sulfonic acid may be
present in a positive amount, or from 0.1 wt. % to 0.6 wt. %. In
some cases, the amount of terephthalylidene dicamphor sulfonic acid
is present in an amount of about 0.3 wt. %.
[0076] More specifically, the sunscreen composition may have the
following amounts of UV filters: [0077] about 3.5 to about 4.5 wt.
% butyl methoxydibenzoylmethane; [0078] about 3.0 to about 4.0 wt.
% ethylhexyl triazone; [0079] about 1.0 to about 2.0 wt. %
drometrizole trisiloxane; [0080] about 1.5 to about 2.5 wt. %
homosalate; [0081] about 1.5 to about 2.5 wt. % ethylhexyl
salicylate; [0082] about 4.0 to about 5.0 wt. % octocrylene; and
[0083] about 0.1 to about 0.5 wt. % terephthalylidene dicamphor
sulfonic acid.
[0084] In some cases, the terephthalylidene dicamphor sulfonic acid
is in an amount of about 0.3 wt. %.
[0085] The total amount of the combination of UV filters can vary
depending on the desired SPF and overall UV filtering strength of a
final sunscreen composition. In one aspect, the total amount of the
combination of UV filters in a sunscreen combination is about 50,
40, 30, 25, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6,
5, 4, 3, 2, or 1 wt. % or less, so long as a positive amount of the
combination of UV filters is present. In another aspect, the
sunscreen formulation has an SPF value that is at least about 5,
10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 times the total
weight percent of the combination of UV filters of the sunscreen
compositions. For example, as shown in the examples, it is possible
for a composition comprising about 17.4 wt. % of a total
combination of UV filters to exhibit an in vitro SPF of 358
(Example 1) (the SPF is about 20.6 times higher than the total
amount of the combination of UV filters used in the
composition).
[0086] The present disclosure makes it possible to achieve the
described SPFs in sunscreen compositions without the use of
boosters, or essentially free of boosters, e.g.,
sorbeth-2-hexaoleate. Although boosters may be included in the
sunscreen compositions of the instant disclosure, they are not
required. In some cases, a booster is included in the sunscreen
compositions to further raise the SPF beyond the amount achieved by
the synergistic combination of UV filters alone.
[0087] Sunscreen compositions according to the present disclosure
can be formulated to achieve a variety of different SPFs. For
example, the sunscreen formulations can have an in vitro or in vivo
SPF of at least 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65,
70, 75, 80, 85, 90, 95, 100, 105, 110, 115, 120, 125, 135, 150,
175, 200, 225, 250, 300. 325, 350, or higher (or in a range between
any of these values).
[0088] The present disclosure is also directed to methods for
protecting a keratinous substrate from ultraviolet radiation and to
methods of absorbing ultraviolet light. Such methods encompass
applying a sunscreen composition to a keratinous substrate and
subjecting the keratinous substrate to ultraviolet radiation.
Oils/Emollients
[0089] Examples of oils/emollients that may be included in the
sunscreen compositions include: hydrocarbon-based oils of plant
origin, such as liquid triglycerides of fatty acids containing from
4 to 10 carbon atoms, for instance heptanoic or octanoic acid
triglycerides, or alternatively, for example, sunflower oil, corn
oil, soybean oil, marrow oil, grapeseed oil, sesameseed oil,
hazelnut oil, apricot oil, macadamia oil, arara oil, coriander oil,
castor oil, avocado oil, caprylic/capric acid triglycerides, for
instance those sold by the company Stearineries Dubois or those
sold under the names Miglyol 810, 812 and 818 by the company
Dynamit Nobel, jojoba oil, shea butter oil and caprylyl glycol;
synthetic esters and ethers, especially of fatty acids, for
instance Purcellin oil, 2-octyldodecyl stearate, 2-octyldodecyl
erucate, isostearyl isostearate; hydroxylated esters, for instance
isostearyl lactate, octyl hydroxystearate, octyldodecyl
hydroxystearate, diisostearyl malate or triisocetyl citrate; fatty
alcohol heptanoates, octanoates or decanoates; polyol esters, for
instance propylene glycol dioctanoate, neopentyl glycol
diheptanoate and diethylene glycol diisononanoate; and
pentaerythritol esters, for instance pentaerythrityl
tetraisostearate, or isopropyl lauroyl sarcosinate, sold especially
under the trade name Eldew SL 205 by the company Ajinomoto; linear
or branched hydrocarbons, of mineral or synthetic origin, such as
volatile or non-volatile liquid paraffins, and derivatives thereof,
petroleum jelly, polydecenes, isohexadecane, isododecane,
hydrogenated polyisobutene such as Parleam oil, or the mixture of
n-undecane (C.sub.11) and of n-tridecane (C.sub.13) sold under the
reference Cetiol UT by the company Cognis; fluoro oils that are
partially hydrocarbon-based and/or silicone-based, for instance
those described in document JP-A-2 295 912; silicone oils, for
instance volatile or non-volatile polymethylsiloxanes (PDMS) with a
linear or cyclic silicone chain, which are liquid or pasty at room
temperature, in particular volatile silicone oils, especially
cyclopolydimethylsiloxanes (cyclomethicones) such as
cyclohexadimethylsiloxane and cyclopentadimethylsiloxane;
polydimethylsiloxanes comprising alkyl, alkoxy or phenyl groups,
which are pendent or at the end of a silicone chain, these groups
containing from 2 to 24 carbon atoms; phenyl silicones, for
instance phenyl trimethicones, phenyl dimethicones,
phenyltrimethylsiloxydiphenylsiloxanes, diphenyl dimethicones,
diphenylmethyldiphenyltrisiloxanes or 2-phenylethyl trimethylsiloxy
silicates, and polymethylphenylsiloxanes; mixtures thereof.
[0090] Additional examples include benzoic acid esters of
C.sub.9-C.sub.15 alcohols, isononyl iso-nonanoate,
C.sub.12-C.sub.15 alkyl benzoate, or any combinations thereof.
[0091] Specific examples of oils/emollients include cocoglyceride,
cyclomethicone, dimethicone, dicapryl maleate, caprylic/capric
triglyceride, isopropyl myristate, octyl stearate, isostearyl
linoleate, lanolin oil, coconut oil, cocoa butter, olive oil,
avocado oil, aloe extracts, jojoba oil, castor oil, fatty acid,
oleic acid, stearic acid, fatty alcohol, cetyl alcohol, hexadecyl
alcohol, diisopropyl adipate, hydroxybenzoate esters, benzoic acid
esters of C.sub.9-C.sub.15 alcohols, isononyl iso-nonanoate,
alkanes, mineral oil, silicone, dimethyl polysiloxane, ether,
polyoxypropylene butyl ether, polyoxypropylene cetyl ether,
C.sub.12-C.sub.15 alkyl benzoate, aryl alkyl benzoate, Isopropyl
Lauroyl sarcosinate, and any combinations thereof.
[0092] Examples of hydrophilic organic solvents that may be
included in the sunscreen compositions include: [0093] monohydric
C.sub.1-C.sub.8 alcohols such as ethanol, propanol, butanol,
isopropanol, isobutanol; [0094] Polyethylene glycols from 6 to 80
ethylene oxides such as propylene glycol, isoprene glycol, butylene
glycol, glycerol, sorbitol; [0095] mono or di-alkyl isosorbides
such as dimethyl isosorbide;
[0096] Examples of amphiphilic organic solvents include:
polypropylene glycol (PPG) like propylene glycol alkyl ester or
alkyl ether of PPG like PPG-23 oleyl ether and PPG-36 oleate.
[0097] The above lists are only examples and not limiting.
[0098] The total amount of oils/emollient present in the
compositions is typically about 0.1, 0.5, 1.0, or 2.5 wt. % to
about 5.0, 7.5, 10.0, 15.0, 20.0, or 30 wt. % of the total weight
of the composition.
[0099] Film Formers
[0100] Film-formers are often incorporated into sunscreen
compositions to ensure even coverage of the UV filters and can be
used to render the composition water resistant. The film former is
typically a hydrophobic material that imparts film forming and/or
waterproofing characteristics. One such agent is polyethylene,
which is available from New Phase Technologies as Performalene.RTM.
400, a polyethylene having a molecular weight of 400. Another
suitable film former is polyethylene 2000 (molecular weight of
2000), which is available from New Phase Technologies as
Performalene.RTM.. Yet, another suitable film former is synthetic
wax, also available from New Phase Technologies as Performa.RTM.
V-825. Other typical film-formers include acrylates/acrylamide
copolymer, acrylates copolymer, acrylates/C.sub.12-C.sub.22
alkylmethacrylate copolymer, polyethylene, waxes,
VP/dimethiconylacrylate/polycarbamylpolyglycol ester, butylated
PVP, PVP/hexadecene copolymer, octadecene/MA copolymer,
PVP/eicosene copolymer, tricontanyl PVP, Brassica
Campestris/Aleuritis Fordi Oil copolymer, decamethyl
cyclopentasiloxane (and) trimethylsiloxysilicate, and mixtures
thereof. In some cases, the film former is
acrylates/C.sub.12-C.sub.22 alkylmethacrylate copolymer sold under
the tradename Allianz OPT.RTM. by ISP.
[0101] Many of the common film-forming polymers included in
sunscreen compositions are not soluble in ethanol (such as
PVP/Eicosene copolymer). A common film-former employed in ethanol
based sunscreen products is Dermacryl LT or Dermacryl 79 marketed
by Akzo Nobel (INCI Name: acrylates/octylacrylamide copolymner).
Dermacryl LT (CAS Number: 80570-62-3) is a hydrophobic, high
molecular weight carboxylated acrylic copolymer. It functions as a
film-former in a broad range of cosmetic formulations, imparting
waterproofing, increased occlusivity and decreased rub-off of
actives.
[0102] The above lists are only examples and not limiting.
[0103] The total amount of film-formers present in the compositions
is typically in an amount of about 0.1, 0.5, 1.0, or 5 wt. % to
about 5, 10, 20, or 25 wt. %, based on the total weight of the
composition.
Emulsifiers
[0104] The sunscreen compositions typically include at least one
emulsifier such as an amphoteric, anionic, cationic or nonionic
emulsifier, used alone or as a mixture, and optionally a
co-emulsifier. The emulsifiers are chosen in an appropriate manner
according to the emulsion to be obtained (W/O or O/W). The
emulsifier and the co-emulsifier are generally present in the
composition in a proportion ranging from 0.3% to 30% by weight and
preferably from 0.5% to 20% by weight relative to the total weight
of the composition.
[0105] For W/O emulsions, examples of emulsifiers that may be
mentioned include dimethicone copolyols, such as the mixture of
cyclomethicone and dimethicone copolyol sold under the trade name
DC 5225 C by the company Dow Corning, and alkyl dimethicone
copolyols such as the lauryl dimethicone copolyol sold under the
name Dow Corning 5200 Formulation Aid by the company Dow Corning,
and the cetyl dimethicone copolyol sold under the name Abil EM
90.TM. by the company Goldschmidt. A crosslinked elastomeric solid
organopolysiloxane comprising at least one oxyalkylene group, such
as those obtained according to the procedure of Examples 3, 4 and 8
of U.S. Pat. No. 5,412,004 and of the examples of U.S. Pat. No.
5,811,487, especially the product of Example 3 (synthesis example)
of U.S. Pat. No. 5,412,004, such as the product sold under the
reference KSG 21 by the company Shin-Etsu, may also be used as
surfactants for W/O emulsions.
[0106] For O/W emulsions, examples of emulsifiers that may be
mentioned include nonionic emulsifiers such as oxyalkylenated (more
particularly polyoxyethylenated) fatty acid esters of glycerol;
oxyalkylenated fatty acid esters of sorbitan; oxyalkylenated
(oxyethylenated and/or oxypropylenated) fatty acid esters;
oxyalkylenated (oxyethylenated and/or oxypropylenated) fatty
alcohol ethers; sugar esters such as sucrose stearate; and mixtures
thereof.
[0107] The fatty acid esters of a sugar that can be used as
nonionic amphiphilic lipids can be chosen in particular from the
group comprising esters or mixtures of esters of a C.sub.8-C.sub.22
fatty acid and of sucrose, of maltose, of glucose or of fructose,
and esters or mixtures of esters of a C.sub.14-C.sub.22 fatty acid
and of methylglucose.
The C.sub.8-C.sub.22 or C.sub.14-C.sub.22 fatty acids forming the
fatty unit of the esters that can be used in the emulsion comprise
a saturated or unsaturated linear alkyl chain having, respectively,
from 8 to 22 or from 14 to 22 carbon atoms. The fatty unit of the
esters can be chosen in particular from stearates, behenates,
arachidonates, palmitates, myristates, laurates, caprates and
mixtures thereof.
[0108] By way of example of esters or of mixtures of esters of a
fatty acid and of sucrose, of maltose, of glucose or of fructose,
mention may be made of sucrose monostearte, sucrose distearate,
sucrose tristearate and mixtures thereof, such as the products sold
by the company Croda under the name Crodesta F50, F70, F110 and
F160 having, respectively, an HLB (Hydrophilic Lipophilic Balance)
of 5, 7, 11 and 16; and, by way of example of esters or of mixtures
of esters of a fatty acid and of methylglucose, mention may be made
of the disearate of methylglucose and of polyglycerol-3, sold by
the company Goldschmidt under the name Tego-care 450. Mention may
also be made of glucose monoesters or maltose monoesters, such as
methyl O-hexadecanoyl-6-D-glucoside and
O-hexadecanoyl-6-D-maltoside.
[0109] The fatty alcohol ethers of a sugar that can be used as
nonionic amphiphilic lipids can be chosen in particular form the
group comprising ethers or mixtures of ethers of a C.sub.8-C.sub.22
fatty alcohol and of glucose, of maltose, of sucrose or of
fructose, and ethers or mixtures of ethers of a C.sub.14-C.sub.22
fatty alcohol and of methylglucose. They are in particular
alkylpolyglucosides.
[0110] The C.sub.8-C.sub.22 or C.sub.14-C.sub.22 fatty alcohols
forming the fatty unit of the ethers that can be used in the
emulsion of the instant disclosure comprise a saturated or
unsaturated linear alkyl chain having, respectively, from 8 to 22
or from 14 to 22 carbon atoms. The fatty unit of the ethers can be
chosen in particular from decyl, cetyl, behenyl, arachidyl,
stearyl, palmityl, myristyl, lauryl, capryl and hexadecanoyl units,
and mixtures thereof such as cetearyl.
[0111] By way of example of fatty alcohol ethers of a sugar,
mention may be made of alkylpolyglucosides, such as decylglucoside
and laurylglucoside sold, for example, by the company Henkel under
the respective names Plantaren 2000 and Plantaren 1200,
cetostearylglucoside, optionally as a mixture with cetostearyl
alcohol, sold, for example, under the name Montanov 68 by the
company Seppic, under the name Tego-care CG90 by the company
Goldschmidt and under the name Emulgade KE3302 by the company
Henkel, and also arachidylglucoside, for example in the form of the
mixture of arachidyl and behenyl alcohols and of arachidylglucoside
sold under the name Montanov 202 by the company Seppic.
[0112] Use is more particularly made, as nonionic amphiphilic lipid
of this type, of sucrose monostearate, sucrose distearate, sucrose
tristearate and mixtures thereof, the distearate of methylglucose
and of polyglycerol-3, and alkylpolyglucosides.
[0113] The glycerol fatty esters that can be used as nonionic
amphiphilic lipids can be chosen in particular from the group
comprising the esters formed from at least one acid comprising a
saturated linear alkyl chain having from 16 to 22 carbon atoms, and
from 1 to 10 glycerol units. Use may be made of one or more of
these glycerol fatty esters in the emulsion of the instant
disclosure.
[0114] These esters may be chosen in particular from stearates,
behenates, arachidates, palmitates and mixtures thereof. Stearates
and palmitates are preferably used.
[0115] By way of example of a surfactant that can be used in the
emulsion of the instant disclosure, mention may be made of
decaglycerol monostearate, distearate, tristearate and
pentastearate (10 glycerol units) (CTFA names: polyglyceryl-10
stearate, polyglyceryl-10 distearate, polyglyceryl-10 tristearate,
polyglyceryl-10 pentastearate), such as the products sold under the
respective names Nikkol Decaglyn 1-S, 2-S, 3-S and 5-S by the
company Nikko, and diglyceryl monostearate (CTFA name:
polyglyceryl-2 stearate) such as the product sold by the company
Nikko under the name Nikkol DGMS.
[0116] The sorbitan fatty esters that can be used as nonionic
amphiphilic lipids chosen in particular from the group comprising
esters of a C.sub.16-C.sub.22 fatty acid and of sorbitan and
oxyethylenated esters of a C.sub.16C.sub.22 fatty acid and of
sorbitan. They are formed from at least one fatty acid comprising
at least one saturated linear alkyl chain, having, respectively,
from 16 to 22 carbon atoms, and from sorbitol or from ethoxylated
sorbitol. The oxyethylenated esters generally comprise from 1 to
100 ethylene oxide units, and preferably from 2 to 40 ethylene
oxide (EO) units.
[0117] These esters can be chosen in particular from stearates,
behenates, arachidates, palmitates and mixtures thereof. Stearates
and palmitates are preferably used.
[0118] By way of example of sorbitan fatty ester and of an
oxyethylenated sorbitan fatty ester, mention may be made of
sorbitan monostearate (CTFA name: sorbitan stearate) sold by the
company ICI under the name Span 60, sorbitan monopalmitate (CTFA
name: sorbitan palmitate) sold by the company ICI under the name
Span 40, or sorbitan 20 EO tristearate (CTFA name: polysorbate 65)
sold by the company ICI under the name Tween 65.
[0119] The ethoxylated fatty ethers are typically ethers made up of
1 to 100 ethylene oxide units and of at least one fatty alcohol
chain having from 16 to 22 carbon atoms. The fatty chain of the
ethers can be chosen in particular from behenyl, arachidyl, stearyl
and cetyl units, and mixtures thereof, such as cetearyl. By way of
example of ethoxylated fatty ethers, mention may be made of ethers
of behenyl alcohol comprising 5, 10, 20 and 30 ethylene oxide units
(CTFA names: beheneth-5, beheneth-10, beheneth-20 and beheneth-30),
such as the products sold under the names Nikkol BB5, BB10, BB20
and BB30 by the company Nikko, and the ether of stearyl alcohol
comprising 2 ethylene oxide units (CTFA name: steareth-2), such as
the product sold under the name Brij 72 by the company ICI.
[0120] The ethoxylated fatty esters that can be used as nonionic
amphiphilic lipids are esters made up of 1 to 100 ethylene oxide
units and of at least one fatty acid chain comprising from 16 to 22
carbon atoms. The fatty chain of the esters can be chosen in
particular from stearate, behenate, arachidate and palmitate units,
and mixtures thereof. By way of example of ethoxylated fatty
esters, mention may be made of the ester of stearic acid comprising
40 ethylene oxide units, such as the product sold under the name
Myrj 52 (CTFA name: PEG-40 stearate) by the company ICI, and the
ester of behenic acid comprising 8 ethylene oxide units (CTFA name:
PEG-8 behenate), such as the product sold under the name Compritol
HD5 ATO by the company Gattefosse.
[0121] The block copolymers of ethylene oxide and of propylene
oxide that can be used as nonionic amphiphilic can be chosen in
particular from poloxamers and in particular from Poloxamer 231,
such as the product sold by the company ICI under the name Pluronic
L81 of formula (V) with x=z=6, y=39 (HLB 2); Poloxamer 282, such as
the product sold by the company ICI under the name Pluronic L92 of
formula (V) with x=z=10, y=47 (HLB 6); and Poloxamer 124, such as
the product sold by the company ICI under the name Pluronic L44 of
formula (V) with x=z=11, y=21 (HLB 16).
[0122] As nonionic amphiphilic lipids, mention may also be made of
the mixtures of nonionic surfactants described in document
EP-A-705593, incorporated herein for reference.
[0123] Suitable hydrophobically-modified emulsifiers include, for
example, inulin lauryl carbamate, commercially available from Beneo
Orafti under the tradename Inutec SP1.
[0124] The above lists are only examples and not limiting.
[0125] The total amount of emulsifier present in the compositions
is typically in an amount of about 0.1, 0.2, or 0.5 wt. % to about
4.0, 5.0, 6.0, or 7.5 wt. %, based on the total weight of the
composition.
Gelling Agent
[0126] Gelling agents may also be included in the sunscreen
compositions. Examples of suitable hydrophilic gelling agents
include carboxyvinyl polymers such as the Carbopol products
(carbomers) and the Pemulen products
(acrylate/C10-C30-alkylacrylate copolymer); polyacrylamides, for
instance the crosslinked copolymers sold under the names Sepigel
305 (CTFA name: polyacrylamide/C13-14 isoparaffin/Laureth 7) or
Simulgel 600 (CTFA name: acrylamide/sodium acryloyldimethyltaurate
copolymer/isohexadecane/polysorbate 80) by the company SEPPIC;
2-acrylamido-2-methylpropanesulfonic acid polymers and copolymers,
which are optionally crosslinked and/or neutralized, for instance
the poly(2-acrylamido-2-methylpropanesulfonic acid) (CTFA name:
ammonium polyacryldimethyltauramide); cellulose-based derivatives
such as hydroxyethyl-cellulose; polysaccharides and especially gums
such as xanthan gum; and mixtures thereof.
[0127] Lipophilic gelling agents (thickeners) that may be mentioned
include modified clays such as hectorite and its derivatives, for
instance the products sold under the name bentone.
[0128] In some instances, the gelling agent is ammonium
acryloyldimethyltaurate/steareth-25 methacrylate crosspolymer,
commercially available from Clariant under the tradename Aristoflex
HMS.
[0129] The above lists are only examples and not limiting.
[0130] The gelling agent is typically used in an amount of about
0.05 to about 1.5% by weight, from about 0.08 to about 1.0% by
weight, or about 0.1 to about 0.5% by weight, based on the total
weight of the composition.
Additional Sunscreen Filters (Protective Agents)
[0131] The sunscreen compositions can include additional sunscreen
filters such as, for example, mineral UV filters. Examples of
mineral UV filters include pigments and nanopigments (mean size of
the primary particles is generally is from 5 nm to 100 nm or from
10 nm to 50 nm) of treated or untreated metal oxides such as, for
example, nanopigments of titanium oxide (amorphous or crystallized
in rutile and/or anatase form), of iron oxide, of zinc oxide, of
zirconium oxide or of cerium oxide. The treated nanopigments are
pigments that have undergone one or more surface treatments of
chemical, electronic, mechanochemical and/or mechanical nature with
compounds as described, for example, in Cosmetics & Toiletries,
February 1990, Vol. 105, pp. 53-64, such as amino acids, beeswax,
fatty acids, fatty alcohols, anionic surfactants, lecithins,
sodium, potassium, zinc, iron or aluminium salts of fatty acids,
metal (titanium or aluminium) alkoxides, polyethylene, silicones,
proteins (collagen or elastin), alkanolamines, silicon oxides,
metal oxides, sodium hexametaphosphate, alumina or glycerol. The
treated nanopigments may more particularly be titanium oxides
treated with: [0132] silica and alumina, such as the products
"Microtitanium Dioxide MT 500 SA" and "Microtitanium Dioxide MT 100
SA" from the company Tayca, and the products "Tioveil Fin",
"Tioveil OP", "Tioveil MOTG" and "Tioveil IPM" from the company
Tioxide; [0133] alumina and aluminium stearate, such as the product
"Microtitanium Dioxide MT 100 T" from the company Tayca; [0134]
alumina and aluminium laurate, such as the product "Microtitanium
Dioxide MT 100 S" from the company Tayca; [0135] iron oxides and
iron stearate, such as the product "Microtitanium Dioxide MT 100 F"
from the company Tayca; [0136] silica, alumina and silicone, such
as the products "Microtitanium Dioxide MT 100 SAS", "Microtitanium
Dioxide MT 600 SAS" and "Microtitanium Dioxide MT 500 SAS" from the
company Tayca; [0137] sodium hexametaphosphate, such as the product
"Microtitanium Dioxide MT 150 W" from the company Tayca; [0138]
octyltrimethoxysilane, such as the product "T-805" from the company
Degussa; [0139] alumina and stearic acid, such as the product
"UVT-M160" from the company Kemira; [0140] alumina and glycerol,
such as the product "UVT-M212" from the company Kemira; [0141]
alumina and silicone, such as the product "UVT-M262" from the
company Kemira.
[0142] Other titanium oxide nanopigments treated with a silicone
are TiO.sub.2 treated with octyltrimethylsilane and for which the
mean size of the elementary particles is between 25 and 40 nm, such
as the product sold under the trade name "T805" by the company
Degussa Silices, TiO.sub.2 treated with a polydimethylsiloxane and
for which the mean size of the elementary particles is 21 nm, such
as the product sold under the trade name "70250 Cardre UF TiO2SI3"
by the company Cardre, anatase/rutile TiO.sub.2 treated with a
polydimethylhydrogenosiloxane and for which the mean size of the
elementary particles is 25 nm, such as the product sold under the
trade name "Microtitanium Dioxide USP Grade Hydrophobic" by the
company Color Techniques.
[0143] Uncoated titanium oxide nanopigments are sold, for example,
by the company Tayca under the trade names "Microtitanium Dioxide
MT 500 B" or "Microtitanium Dioxide MT 600 B", by the company
Degussa under the name "P 25", by the company Wackher under the
name "Oxyde de titane transparent PW", by the company Myoshi Kasei
under the name "UFTR", by the company Tomen under the name "ITS"
and by the company Tioxide under the name "Tioveil AQ".
[0144] The uncoated zinc oxide nanopigments are, for example:
[0145] those sold under the name "Z-Cote" by the company Sunsmart;
[0146] those sold under the name "Nanox" by the company Elementis;
and [0147] those sold under the name "Nanogard WCD 2025" by the
company Nanophase Technologies.
[0148] The coated zinc oxide nanopigments are, for example: [0149]
those sold under the name "Zinc Oxide CS-5" by the company Toshibi
(ZnO coated with polymethylhydrogenosiloxane); [0150] those sold
under the name "Nanogard Zinc Oxide FN" by the company Nanophase
Technologies (as a 40% dispersion in Finsolv TN, C.sub.12-C.sub.15
alkyl benzoate); [0151] those sold under the name "Daitopersion
ZN-30" and "Daitopersion ZN-50" by the company Daito (dispersions
in cyclopolymethylsiloxane/oxyethylenated polydimethylsiloxane,
containing 30% or 50% of nanozinc oxides coated with silica and
polymethylhydrogenosiloxane); [0152] those sold under the name "NFD
Ultrafine ZNO" by the company Daikin (ZnO coated with
perfluoroalkyl phosphate and copolymer based on perfluoroalkylethyl
as a dispersion in cyclopentasiloxane); [0153] those sold under the
name "SPD-Z1" by the company Shin-Etsu (ZnO coated with
silicone-grafted acrylic polymer, dispersed in
cyclodimethylsiloxane); [0154] those sold under the name "Escalol
Z100" by the company ISP (alumina-treated ZnO dispersed in an
ethylhexyl methoxycinnamate/PVP-hexadecene/methicone copolymer
mixture); [0155] those sold under the name "Fuji ZNO-SMS-10" by the
company Fuji Pigment (ZnO coated with silica and
polymethylsilsesquioxane); and [0156] those sold under the name
"Nanox Gel TN" by the company Elementis (ZnO dispersed at a
concentration of 55% in C.sub.12-C.sub.15 alkyl benzoate with
hydroxystearic acid polycondensate).
[0157] The uncoated cerium oxide nanopigments are sold under the
name "Colloidal Cerium Oxide" by the company Rhone-Poulenc. The
uncoated iron oxide nanopigments are sold, for example, by the
company Arnaud under the names "Nanogard WCD 2002 (FE 45B)",
"Nanogard Iron FE 45 BL AQ", "Nanogard FE 45R AQ" and "Nanogard WCD
2006 (FE 45R)" or by the company Mitsubishi under the name
"TY-220". The coated iron oxide nanopigments are sold, for example,
by the company Arnaud under the names "Nanogard WCD 2008 (FE 45B
FN)", "Nanogard WCD 2009 (FE 45B 556)", "Nanogard FE 45 BL 345" and
"Nanogard FE 45 BL" or by the company BASF under the name
"Transparent Iron Oxide".
[0158] Mixtures of metal oxides may also be used, especially of
titanium dioxide and of cerium dioxide, including the silica-coated
equal-weight mixture of titanium dioxide and of cerium dioxide,
sold by the company Ikeda under the name "Sunveil A", and also the
alumina, silica and silicone-coated mixture of titanium dioxide and
of zinc dioxide, such as the product "M 261" sold by the company
Kemira, or the alumina, silica and glycerol-coated mixture of
titanium dioxide and of zinc dioxide, such as the product "M 211"
sold by the company Kemira.
[0159] The above lists are only examples and not limiting.
[0160] The compositions according to the instant disclosure may be
prepared according to techniques that are well known to those
skilled in the art, in particular those intended for the
preparation of emulsions of oil-in-water or water-in-oil type. They
may be in particular in the form of a simple or complex emulsion
(O/W, W/O, O/W/O or W/O/W emulsion) such as a cream or a milk, in
the form of a gel or a cream-gel, or in the form of a lotion.
[0161] The instant disclosure will be better understood from the
examples that follow, all of which are intended for illustrative
purposes only and are not meant to limit the scope of the instant
disclosure in any way.
Examples 1-5
[0162] Samples comprising different amounts of UV filters were
prepared by dissolving the UV filters in ethanol and solvent as
illustrated in the table below.
TABLE-US-00002 TABLE 1 Ingredient Range butyl
methoxydibenzoylmethane 1.4-3.8% (Avobenzone) ethylhexyl triazone
1.3-3.7% (Uvinul T150) drometrizole trisiloxane 1.4-5.0% (Mexoryl
XL) Homosalate 2.5-7.8% ethylhexyl salicylate 1.8-3.4% (Octisalate)
Octocrylene 1.8-5.0% terephthalylidene dicamphor sulfonic acid
about 0.3 (Mexoryl SX) (about 0.9%) TEA(Triethanolamine) 0-1.05%
Polysorbate 20 .sup. 5.50% Propylene Glycol .sup. 5% Eldew SL205
Solvent* .sup. 10.0% Dermacryl 79** .sup. 12.5% Ethanol Qs 100%
*Eldew SL 205 (Ajinomoto) is Isopropyl Lauroyl Sarcosinate
(emollient) **Dermacryl 79 (Akzo Nobel) is an
acrylate/octylacrylamide Copolymner (film-former)
[0163] Each sample was applied to a PMMA (polymethyl methacrylate)
plate with a draw down bar to control the thickness and the
homogeneity of the film. The in vitro SPF was measured using a
Labsphere 2000. Each measurement was made 6 times (6 times on each
plate) times on 3 plates for each composition. The amount of UV
filters included in each sample and the resulting in vitro SPF is
reported in the table below.
TABLE-US-00003 TABLE 2 ethylhexyl butyl methoxy triazone
drometrizole ethylhexyl terephthalylidene Total SPF
dibenzoylmethane (Uvinul trisiloxane salicylate dicamphor UV in No.
(Avobenzone) T150) (Mexoryl XL) Homosalate (Octisalate) Octocrylene
sulfonic acid Filters vitro 1 3.8 3.4 1.4 2.5 1.8 4.2 0.3 17.4 358
Comparisons 2 1.4 3.1 3.4 7.8 2.2 1.8 0.3 20.0 81 3 3.4 3.7 1.4 2.5
2.2 3.8 0.3 17.3 237 4 3.0 1.3 1.4 5.5 3.4 5.0 0.3 19.9 244 5 3.0
2.8 5.0 2.5 1.8 4.2 0.3 19.6 248
[0164] The following table corresponds to the table above (TABLE 2)
but lists each UV filter as a ratio relative to butyl
methoxydibenzoylmethane.
TABLE-US-00004 TABLE 3 ethylhexyl butyl methoxy triazone
drometrizole ethylhexyl terephthalylidene Total SPF
dibenzoylmethane (Uvinul trisiloxane salicylate dicamphor UV in No.
(Avobenzone) T150) (Mexoryl)XL Homosalate (Octisalat)e Octocrylene
sulfonic acid Filters vitro 1 1.00 0.90 0.37 0.66 0.47 1.11 0.08
17.4 358 Comparisons 2 1.00 2.21 2.43 5.54 1.57 1.29 0.21 20.0 81 3
1.00 1.09 0.41 0.74 0.65 1.12 0.09 17.3 237 4 1.00 0.43 0.47 1.83
1.13 1.67 0.10 19.9 244 5 1.00 0.93 1.67 0.83 0.60 1.40 0.10 19.6
248 *Note: the bolded numbers fall outside the claimed range.
[0165] As illustrated in the tables above, Example 1 has a ratio of
about 1.0:0.9:0.4:0.7:0.5:1.1:0.1 (butyl
methoxydibenzoylmethane:ethylhexyl triazone:drometrizole
trisiloxane:homosalate: ethylhexyl salicylate:octocrylene:
terephthalylidene dicamphor sulfonic acid).
Example 6
Comparative Formulation
[0166] The following oil-in-water emulsion was prepared and the in
vivo SPF measured.
TABLE-US-00005 FORMULA: Comparative Example Phase Ingredients %
wt/wt A-1 Water Q.S. EDTA 0.100 Glycerin 1.0-5.0 Preservative
0.1-2.0 Emulsifier 0.1 to 1.0 B butyl 3.000 methoxydibenzoylmethane
(Avobenzone) ethylhexyl triazone 1.500 (Uvinul T150) drometrizole
trisiloxane 4.000 (Mexoryl XL) Homosalate 10.000 ethylhexyl
salicylate 5.000 (Octisalate) Octocrylene 5.000 terephthalylidene
0.3300 dicamphor sulfonic acid (0.9) (Mexoryl SX) Emulsifiers 0.5
to 4.0 Emollients 1.0 to 8.0 Antioxident 0.05 to 0.15 SPF Booster
3.0-10.0 C Polymeric Emulsifier 0.05-0.30 D TEA 0.1-0.60 D
Silicones 1.0-10.0 E Film former 0.5 to 3.0 F Wetting agent 0.1 to
1.5 Total % UV filters 28.83 (29.4) SPF (in-vivo) 59.4
[0167] The components of the Lotion Sunscreen were combined as
outlined below. [0168] 1) Weigh Phase A and heat to 85.degree. C.
[0169] 2) Weigh Phase B ingredients in another beaker and heat to
85.degree. C. [0170] 3) Add Phase B into Phase A and homogenized
for 20 minutes. Maintain the temperature at 90.degree. C. [0171] 4)
Check emulsion quality. If emulsion quality is good then begin
cooling to room temperature. [0172] 5) Add Phase C into Phase A/B
and homogenize for 5 minutes. [0173] 6) Pass the emulsion through a
high pressure homogenizer two times at 500 bar. [0174] 7) Add phase
D at room temperature and mix for 5 minutes.
[0175] The above formulation is for a comparative sunscreen
formulation that is an oil-in-water emulsion. The UV filters of the
instant disclosure (in the described synergistic ratios) can be
used in the above formulation (or similar formulations) to derive a
sunscreen formulation with improved SPF.
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