U.S. patent application number 15/197877 was filed with the patent office on 2016-10-20 for increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis. The applicant listed for this patent is BUTAMAX ADVANCED BIOFUELS LLC. Invention is credited to Larry Cameron Anthony.
Application Number | 20160304909 15/197877 |
Document ID | / |
Family ID | 42196653 |
Filed Date | 2016-10-20 |
United States Patent Application | 20160304909 |
Kind Code | A1 |
Anthony; Larry Cameron | October 20, 2016 |
Yeast cells with reduced activity of certain enzymes involved in branched chain amino acid biosynthesis in yeast mitochondria are described. Target enzymes include threonine deaminase, isopropylmalate synthase, and optionally branched chain amino acid transaminase.
Inventors: | Anthony; Larry Cameron; (Aston, PA) | ||||||||||
Applicant: |
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Family ID: | 42196653 | ||||||||||
Appl. No.: | 15/197877 | ||||||||||
Filed: | June 30, 2016 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
14848792 | Sep 9, 2015 | 9404117 | ||
15197877 | ||||
14302097 | Jun 11, 2014 | 9163266 | ||
14848792 | ||||
13889999 | May 8, 2013 | 8785166 | ||
14302097 | ||||
12617039 | Nov 12, 2009 | 8465964 | ||
13889999 | ||||
61114072 | Nov 13, 2008 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | C12N 9/1029 20130101; C12Y 203/03013 20130101; Y02P 20/52 20151101; C12N 9/88 20130101; C12N 9/1025 20130101; Y02E 50/10 20130101; C12N 9/1096 20130101; C12Y 206/01042 20130101; C12N 15/81 20130101; C12Y 401/01001 20130101; C12Y 403/01019 20130101; C12P 7/16 20130101 |
International Class: | C12P 7/16 20060101 C12P007/16; C12N 9/88 20060101 C12N009/88; C12N 9/10 20060101 C12N009/10 |
Sequence CWU 1
1
12811731DNASaccharomyces cerevisiae 1atgtcagcta ctctactaaa
gcaaccatta tgtacggttg ttcggcaagg taaacagtcc 60aaagtgtctg gattgaacct
tttgagacta aaggctcatt tgcacagaca acacctgtca 120ccttccttga
taaaactaca ctctgaattg aaattggatg agctgcaaac tgataacacc
180cctgattacg tccgtttagt tttaaggtcc tctgtatacg atgttattaa
tgaatctcca 240atctctcaag gtgtaggttt gtcttcccgt ctaaacacga
atgtcatctt gaaaagagaa 300gatctattgc ctgttttctc tttcaagctt
cgtggtgcct ataacatgat tgccaagttg 360gacgattctc aaagaaacca
gggtgttatt gcctgttcag ctgggaatca tgcccaaggt 420gtggcctttg
ctgctaaaca cttgaaaata cctgctacta tcgttatgcc tgtttgtaca
480ccatctatta agtatcaaaa tgtctcgaga ttagggtctc aagtcgtcct
atatggtaac 540gattttgacg aggctaaggc tgaatgtgcc aaattggctg
aagagcgtgg cttgacgaac 600attcctcctt tcgatcatcc ttatgtcatt
gccggtcaag gtactgtagc tatggaaatc 660ctaagacaag tacgtaccgc
taataagatc ggtgctgtct ttgttcccgt cggcggtggt 720ggtttaattg
ctggtattgg tgcttatttg aaaagggttg ctcctcatat caaaatcatt
780ggtgttgaaa cttacgatgc ggccacttta cataattcct tgcaacgcaa
ccagagaact 840cctttacctg tggtgggtac ttttgccgat ggtacgtctg
tgcgtatgat tggtgaagaa 900acatttagag tcgcccaaca agtggttgat
gaagttgttc ttgttaacac tgacgaaatc 960tgtgctgcag taaaggatat
ttttgaagat actagaagta ttgtagaacc atctggtgcc 1020ctttcagtag
ccggtatgaa gaaatacatc tctaccgtac atccagaaat tgaccacact
1080aaaaacacct atgttcccat cctttctggt gctaacatga actttgatag
attaagattt 1140gtttccgaac gtgctgttct tggtgaagga aaggaagtct
tcatgttagt tactttaccc 1200gacgtccctg gtgcgttcaa gaaaatgcaa
aagatcatcc acccaagatc tgttactgaa 1260ttctcttacc gttacaatga
acatcgtcat gagtcctcta gtgaagtgcc caaggcttac 1320atttacactt
ctttcagcgt cgttgacaga gaaaaggaaa tcaagcaagt tatgcaacag
1380ttgaatgctt taggttttga agctgtggat atctccgata acgaattggc
taaatctcat 1440ggtagatact tggttggtgg tgcttctaag gttcctaatg
aaagaattat ttcatttgaa 1500ttccctgaaa gaccaggtgc cttgactagg
ttccttggag gcctaagcga ttcttggaat 1560cttactttat tccattatag
aaaccatggt gccgatatcg gtaaggtttt agctggtatt 1620tccgttcctc
caagggaaaa cttaaccttc caaaaattct tggaagattt aggctacact
1680tatcatgatg aaactgataa cactgtttat caaaaattct tgaaatatta a
17312576PRTSaccharomyces cerevisiae 2Met Ser Ala Thr Leu Leu Lys
Gln Pro Leu Cys Thr Val Val Arg Gln 1 5 10 15 Gly Lys Gln Ser Lys
Val Ser Gly Leu Asn Leu Leu Arg Leu Lys Ala 20 25 30 His Leu His
Arg Gln His Leu Ser Pro Ser Leu Ile Lys Leu His Ser 35 40 45 Glu
Leu Lys Leu Asp Glu Leu Gln Thr Asp Asn Thr Pro Asp Tyr Val 50 55
60 Arg Leu Val Leu Arg Ser Ser Val Tyr Asp Val Ile Asn Glu Ser Pro
65 70 75 80 Ile Ser Gln Gly Val Gly Leu Ser Ser Arg Leu Asn Thr Asn
Val Ile 85 90 95 Leu Lys Arg Glu Asp Leu Leu Pro Val Phe Ser Phe
Lys Leu Arg Gly 100 105 110 Ala Tyr Asn Met Ile Ala Lys Leu Asp Asp
Ser Gln Arg Asn Gln Gly 115 120 125 Val Ile Ala Cys Ser Ala Gly Asn
His Ala Gln Gly Val Ala Phe Ala 130 135 140 Ala Lys His Leu Lys Ile
Pro Ala Thr Ile Val Met Pro Val Cys Thr 145 150 155 160 Pro Ser Ile
Lys Tyr Gln Asn Val Ser Arg Leu Gly Ser Gln Val Val 165 170 175 Leu
Tyr Gly Asn Asp Phe Asp Glu Ala Lys Ala Glu Cys Ala Lys Leu 180 185
190 Ala Glu Glu Arg Gly Leu Thr Asn Ile Pro Pro Phe Asp His Pro Tyr
195 200 205 Val Ile Ala Gly Gln Gly Thr Val Ala Met Glu Ile Leu Arg
Gln Val 210 215 220 Arg Thr Ala Asn Lys Ile Gly Ala Val Phe Val Pro
Val Gly Gly Gly 225 230 235 240 Gly Leu Ile Ala Gly Ile Gly Ala Tyr
Leu Lys Arg Val Ala Pro His 245 250 255 Ile Lys Ile Ile Gly Val Glu
Thr Tyr Asp Ala Ala Thr Leu His Asn 260 265 270 Ser Leu Gln Arg Asn
Gln Arg Thr Pro Leu Pro Val Val Gly Thr Phe 275 280 285 Ala Asp Gly
Thr Ser Val Arg Met Ile Gly Glu Glu Thr Phe Arg Val 290 295 300 Ala
Gln Gln Val Val Asp Glu Val Val Leu Val Asn Thr Asp Glu Ile 305 310
315 320 Cys Ala Ala Val Lys Asp Ile Phe Glu Asp Thr Arg Ser Ile Val
Glu 325 330 335 Pro Ser Gly Ala Leu Ser Val Ala Gly Met Lys Lys Tyr
Ile Ser Thr 340 345 350 Val His Pro Glu Ile Asp His Thr Lys Asn Thr
Tyr Val Pro Ile Leu 355 360 365 Ser Gly Ala Asn Met Asn Phe Asp Arg
Leu Arg Phe Val Ser Glu Arg 370 375 380 Ala Val Leu Gly Glu Gly Lys
Glu Val Phe Met Leu Val Thr Leu Pro 385 390 395 400 Asp Val Pro Gly
Ala Phe Lys Lys Met Gln Lys Ile Ile His Pro Arg 405 410 415 Ser Val
Thr Glu Phe Ser Tyr Arg Tyr Asn Glu His Arg His Glu Ser 420 425 430
Ser Ser Glu Val Pro Lys Ala Tyr Ile Tyr Thr Ser Phe Ser Val Val 435
440 445 Asp Arg Glu Lys Glu Ile Lys Gln Val Met Gln Gln Leu Asn Ala
Leu 450 455 460 Gly Phe Glu Ala Val Asp Ile Ser Asp Asn Glu Leu Ala
Lys Ser His 465 470 475 480 Gly Arg Tyr Leu Val Gly Gly Ala Ser Lys
Val Pro Asn Glu Arg Ile 485 490 495 Ile Ser Phe Glu Phe Pro Glu Arg
Pro Gly Ala Leu Thr Arg Phe Leu 500 505 510 Gly Gly Leu Ser Asp Ser
Trp Asn Leu Thr Leu Phe His Tyr Arg Asn 515 520 525 His Gly Ala Asp
Ile Gly Lys Val Leu Ala Gly Ile Ser Val Pro Pro 530 535 540 Arg Glu
Asn Leu Thr Phe Gln Lys Phe Leu Glu Asp Leu Gly Tyr Thr 545 550 555
560 Tyr His Asp Glu Thr Asp Asn Thr Val Tyr Gln Lys Phe Leu Lys Tyr
565 570 575 31803DNASchizosaccharomyces pombe 3atgactggaa
cgagttttta cacttcggta ctcagattgg gacgattggc tcaacagggc 60ctaaaattcc
aatctgtaaa acatattcgt ccatcatgtt tttcatcttt tggattacaa
120gctaaacgtt ggaactctac tcaacaaaat gatagttcta ttgattgttt
agaacctaag 180ctgcaaggaa ttattgaaga caatatttct ccctcgacgg
cacaaaaaga aatatcagac 240atcaagttta atattccaaa ggaaatgctt
cttccagatg gaactcctga ttatttacgt 300ttgactctca cgtctaacgt
gtatgaagtt atcaaggaga ctcctcttac aaagggtgtt 360gtcatttctg
aaagtaccgg tgttccagtc tacttaaaac gtgaagatct cactcctgtg
420ttttcattta aaattcgagg ggctcataat aaaatggctt ctcttgataa
gcagtcattg 480aaaaatggag tcattgcttg ttccgctggc aatcacgccc
agggtgttgc ttactccgct 540aggactcttg gtgtaaaagc taccattgtt
atgcctcaga atactcctga aatcaaatgg 600aggaacgtta agagattggg
cgctaatgtt ctcttacatg gagctaattt tgacattgct 660aaagcagaat
gtgcacgttt ggctaaagag caaaatctcg aagttattca tccctttgac
720gatccttatg taattgctgg acaaggaacc attggacttg aaattcttca
tcaaatagat 780cttcgcaagc tggatgctat ttactgcgct gttggcggtg
gtggtttaat tgctggaata 840gctacttacg ttaagcgtat tgctccccat
gttaaggtca ttggtgtcga gacatttgac 900gctgatgctt taaaaaagtc
tttgaaggac aaaaagcggg taacccttaa ggaagttggc 960ttattcgctg
atggaactgc tgtgaaactt gttggagagg aaaccttccg tcttgtctcc
1020aagaatattg acgatgtagt tcttgttgac aaagatgaga tttgtgcagc
cattaaggat 1080gtttttttgg atacccgttc agtggtcgaa ccatcaggag
ctatggctgt tgctggtatg 1140aagcgttatg tcgctaaaca caagcctaaa
aatcccaatg ctgctcaggt ttgcatctta 1200agtggtgcca atatggactt
tgatcgcctt agatttattg ctgagcgtgc tgatcttggt 1260ttgaacaagg
aagtattctt gagtgtcact attcctgagc gccctggttc atttgaagcc
1320ctacacaaca ttattactcc acgtagtatt accgaatttt cttatcgtta
cgataatgat 1380gactatgcta acatttacac atcgtttgtg gtaaaggacc
gtgcaactga attgcctttg 1440attcttcaac aaatctctga gcaaaatatg
gttgcagaag atatcagcga taatgaactt 1500gctaaaactc atgcccgtta
tcttattgga ggaaaatcat ctgtttcaaa agagcgtttg 1560taccgattgg
atttccctga acgccctgga gctttatgta agtttttgag gagtataaag
1620gaagtttgca gcatttccct tttccattat cgtaattgtg gtggagatat
agctagtgtg 1680cttgctggcc ttagagtttt tgatggccaa gtggaaaaac
ttcattcagt tttggaagag 1740attggataca actgggtgga cgaaacaaat
aatcccgttt acttgcgcta tcttcgtaaa 1800tag
18034600PRTSchizosaccharomyces pombe 4Met Thr Gly Thr Ser Phe Tyr
Thr Ser Val Leu Arg Leu Gly Arg Leu 1 5 10 15 Ala Gln Gln Gly Leu
Lys Phe Gln Ser Val Lys His Ile Arg Pro Ser 20 25 30 Cys Phe Ser
Ser Phe Gly Leu Gln Ala Lys Arg Trp Asn Ser Thr Gln 35 40 45 Gln
Asn Asp Ser Ser Ile Asp Cys Leu Glu Pro Lys Leu Gln Gly Ile 50 55
60 Ile Glu Asp Asn Ile Ser Pro Ser Thr Ala Gln Lys Glu Ile Ser Asp
65 70 75 80 Ile Lys Phe Asn Ile Pro Lys Glu Met Leu Leu Pro Asp Gly
Thr Pro 85 90 95 Asp Tyr Leu Arg Leu Thr Leu Thr Ser Asn Val Tyr
Glu Val Ile Lys 100 105 110 Glu Thr Pro Leu Thr Lys Gly Val Val Ile
Ser Glu Ser Thr Gly Val 115 120 125 Pro Val Tyr Leu Lys Arg Glu Asp
Leu Thr Pro Val Phe Ser Phe Lys 130 135 140 Ile Arg Gly Ala His Asn
Lys Met Ala Ser Leu Asp Lys Gln Ser Leu 145 150 155 160 Lys Asn Gly
Val Ile Ala Cys Ser Ala Gly Asn His Ala Gln Gly Val 165 170 175 Ala
Tyr Ser Ala Arg Thr Leu Gly Val Lys Ala Thr Ile Val Met Pro 180 185
190 Gln Asn Thr Pro Glu Ile Lys Trp Arg Asn Val Lys Arg Leu Gly Ala
195 200 205 Asn Val Leu Leu His Gly Ala Asn Phe Asp Ile Ala Lys Ala
Glu Cys 210 215 220 Ala Arg Leu Ala Lys Glu Gln Asn Leu Glu Val Ile
His Pro Phe Asp 225 230 235 240 Asp Pro Tyr Val Ile Ala Gly Gln Gly
Thr Ile Gly Leu Glu Ile Leu 245 250 255 His Gln Ile Asp Leu Arg Lys
Leu Asp Ala Ile Tyr Cys Ala Val Gly 260 265 270 Gly Gly Gly Leu Ile
Ala Gly Ile Ala Thr Tyr Val Lys Arg Ile Ala 275 280 285 Pro His Val
Lys Val Ile Gly Val Glu Thr Phe Asp Ala Asp Ala Leu 290 295 300 Lys
Lys Ser Leu Lys Asp Lys Lys Arg Val Thr Leu Lys Glu Val Gly 305 310
315 320 Leu Phe Ala Asp Gly Thr Ala Val Lys Leu Val Gly Glu Glu Thr
Phe 325 330 335 Arg Leu Val Ser Lys Asn Ile Asp Asp Val Val Leu Val
Asp Lys Asp 340 345 350 Glu Ile Cys Ala Ala Ile Lys Asp Val Phe Leu
Asp Thr Arg Ser Val 355 360 365 Val Glu Pro Ser Gly Ala Met Ala Val
Ala Gly Met Lys Arg Tyr Val 370 375 380 Ala Lys His Lys Pro Lys Asn
Pro Asn Ala Ala Gln Val Cys Ile Leu 385 390 395 400 Ser Gly Ala Asn
Met Asp Phe Asp Arg Leu Arg Phe Ile Ala Glu Arg 405 410 415 Ala Asp
Leu Gly Leu Asn Lys Glu Val Phe Leu Ser Val Thr Ile Pro 420 425 430
Glu Arg Pro Gly Ser Phe Glu Ala Leu His Asn Ile Ile Thr Pro Arg 435
440 445 Ser Ile Thr Glu Phe Ser Tyr Arg Tyr Asp Asn Asp Asp Tyr Ala
Asn 450 455 460 Ile Tyr Thr Ser Phe Val Val Lys Asp Arg Ala Thr Glu
Leu Pro Leu 465 470 475 480 Ile Leu Gln Gln Ile Ser Glu Gln Asn Met
Val Ala Glu Asp Ile Ser 485 490 495 Asp Asn Glu Leu Ala Lys Thr His
Ala Arg Tyr Leu Ile Gly Gly Lys 500 505 510 Ser Ser Val Ser Lys Glu
Arg Leu Tyr Arg Leu Asp Phe Pro Glu Arg 515 520 525 Pro Gly Ala Leu
Cys Lys Phe Leu Arg Ser Ile Lys Glu Val Cys Ser 530 535 540 Ile Ser
Leu Phe His Tyr Arg Asn Cys Gly Gly Asp Ile Ala Ser Val 545 550 555
560 Leu Ala Gly Leu Arg Val Phe Asp Gly Gln Val Glu Lys Leu His Ser
565 570 575 Val Leu Glu Glu Ile Gly Tyr Asn Trp Val Asp Glu Thr Asn
Asn Pro 580 585 590 Val Tyr Leu Arg Tyr Leu Arg Lys 595 600 5
1710DNACandida albicans 5atgtcaatca ctcgactttc aagtgctaag
cttttattaa gtagcacgtc acgcaaacta 60caggtattaa ggttaaatag tacaacgacc
aaacccctta cccctagaca aaaatggccg 120gaacttttgg actctgattt
catagtgaat tctcaaggtg aaaaacaacc cgattatgtc 180aaattgatat
taacttcaag agtgtacgat gttgtggacg aagccggtac accattaacc
240aatgctatca atttatctca tagatgtggt gccaatatct atcttaaaag
agaggatttg 300ttaccagttt tttcgttcaa gttgagaggt gcatataata
tgattgccca tttgcattca 360aattccccac aacctatatc aggggttatt
gcttgttcgg caggaaacca tgcccaagga 420gttgcatttt cttcgagtaa
attaaatatc ccagccacaa ttgtcatgcc tactccaaca 480ccttctatca
agtacaccaa tgtttcaaga ttaggtgccc aagttgtatt gtatggagac
540gattttgatt cagcaaaaca agagtgtgaa aggttgagca cagagcaaaa
tttaatcaac 600attccacctt ttaaccatcc ttacgttatt gctggtcagg
gtacaattgc tttagagatt 660gctagacaat tgagattaga taaattgaat
gccatatttg ttcctgtagg aggaggtggc 720ttaattgcag gtgtggcagt
gtatttgaag catattgccc ctcacgtcaa aatcatagga 780gtagaaacgt
atgatgccga tgcattgaac cagtctttaa agaatagtcg cctggttact
840ttggaaaaag ttggtttgtt tgcagatggt actgccgtga aagttcttgg
agatgaaacc 900tggagattag caaaagaata tgtagatgaa gttgtgcttg
tcaacactga tgaattgtgt 960gctgctatta aggatatttt tgaagacaca
aggctgattg tcgaaccttc tggagcattg 1020tctgttgctg gattgaaaaa
gtacattgaa gaacacccag agattgacca cagagataag 1080acatatgttc
cagttttgtc tggtgctaat atgaattttg atagattaag gtttgttagt
1140gaaagagcag ttttgggtga aggaaaagaa gtctcattgg ctgttaccat
tcctgagaaa 1200cctggtgagt ttgccagatt gcaaaaagtt atcaatccac
gtgctatcac tgaattttca 1260tacaggtaca acggtgaaga aaacgccgat
atatttgtgt cctttaatgt agtggacaag 1320aaaaaagaaa agtcttcagt
tatagcagca atggaaaatt gtggatttga agttgttgat 1380atttcagaaa
acgaattggc aaaatctcat ggacgttatt tagttggtgg taagtcacaa
1440tctacaaaat cctcaaatga aaaaatctat caatttgaat tccctgaaaa
accaaatgct 1500ttgtttaact ttttacaagc attaaggagc gactggaata
tcagcttgtt taattataga 1560aatcatggac atgatgtcgg aaaaatcttg
tgtgcattta ctcttcctga aggatctgag 1620gaagacttcc aagaattttt
aaagaatgtt ggttacactt ttgttgatga atctgataac 1680atcttttaca
aaaaattctt gagaagctaa 17106569PRTCandida albicans 6Met Ser Ile Thr
Arg Leu Ser Ser Ala Lys Leu Leu Leu Ser Ser Thr 1 5 10 15 Ser Arg
Lys Leu Gln Val Leu Arg Leu Asn Ser Thr Thr Thr Lys Pro 20 25 30
Leu Thr Pro Arg Gln Lys Trp Pro Glu Leu Leu Asp Ser Asp Phe Ile 35
40 45 Val Asn Ser Gln Gly Glu Lys Gln Pro Asp Tyr Val Lys Leu Ile
Leu 50 55 60 Thr Ser Arg Val Tyr Asp Val Val Asp Glu Ala Gly Thr
Pro Leu Thr 65 70 75 80 Asn Ala Ile Asn Leu Ser His Arg Cys Gly Ala
Asn Ile Tyr Leu Lys 85 90 95 Arg Glu Asp Leu Leu Pro Val Phe Ser
Phe Lys Leu Arg Gly Ala Tyr 100 105 110 Asn Met Ile Ala His Leu His
Ser Asn Ser Pro Gln Pro Ile Ser Gly 115 120 125 Val Ile Ala Cys Ser
Ala Gly Asn His Ala Gln Gly Val Ala Phe Ser 130 135 140 Ser Ser Lys
Leu Asn Ile Pro Ala Thr Ile Val Met Pro Thr Pro Thr 145 150 155 160
Pro Ser Ile Lys Tyr Thr Asn Val Ser Arg Leu Gly Ala Gln Val Val 165
170 175 Leu Tyr Gly Asp Asp Phe Asp Ser Ala Lys Gln Glu Cys Glu Arg
Leu 180 185 190 Ser Thr Glu Gln Asn Leu Ile Asn Ile Pro Pro Phe Asn
His Pro Tyr 195 200 205 Val Ile Ala Gly Gln Gly Thr Ile Ala Leu Glu
Ile Ala Arg Gln Leu 210 215 220 Arg Leu Asp Lys Leu Asn Ala Ile Phe
Val Pro Val Gly Gly Gly Gly 225 230 235 240 Leu Ile Ala Gly Val Ala
Val Tyr Leu Lys His Ile Ala Pro His Val 245 250 255 Lys Ile Ile Gly
Val Glu Thr Tyr Asp Ala Asp Ala Leu Asn Gln Ser 260 265 270 Leu Lys
Asn Ser Arg Ser Val Thr Leu Glu Lys Val Gly Leu Phe Ala 275 280
285
Asp Gly Thr Ala Val Lys Val Leu Gly Asp Glu Thr Trp Arg Leu Ala 290
295 300 Lys Glu Tyr Val Asp Glu Val Val Leu Val Asn Thr Asp Glu Leu
Cys 305 310 315 320 Ala Ala Ile Lys Asp Ile Phe Glu Asp Thr Arg Ser
Ile Val Glu Pro 325 330 335 Ser Gly Ala Leu Ser Val Ala Gly Leu Lys
Lys Tyr Ile Glu Glu His 340 345 350 Pro Glu Ile Asp His Arg Asp Lys
Thr Tyr Val Pro Val Leu Ser Gly 355 360 365 Ala Asn Met Asn Phe Asp
Arg Leu Arg Phe Val Ser Glu Arg Ala Val 370 375 380 Leu Gly Glu Gly
Lys Glu Val Ser Leu Ala Val Thr Ile Pro Glu Lys 385 390 395 400 Pro
Gly Glu Phe Ala Arg Leu Gln Lys Val Ile Asn Pro Arg Ala Ile 405 410
415 Thr Glu Phe Ser Tyr Arg Tyr Asn Gly Glu Glu Asn Ala Asp Ile Phe
420 425 430 Val Ser Phe Asn Val Val Asp Lys Lys Lys Glu Lys Ser Ser
Val Ile 435 440 445 Ala Ala Met Glu Asn Cys Gly Phe Glu Val Val Asp
Ile Ser Glu Asn 450 455 460 Glu Leu Ala Lys Ser His Gly Arg Tyr Leu
Val Gly Gly Lys Ser Gln 465 470 475 480 Ser Thr Lys Ser Ser Asn Glu
Lys Ile Tyr Gln Phe Glu Phe Pro Glu 485 490 495 Lys Pro Asn Ala Leu
Phe Asn Phe Leu Gln Ala Leu Arg Ser Asp Trp 500 505 510 Asn Ile Ser
Leu Phe Asn Tyr Arg Asn His Gly His Asp Val Gly Lys 515 520 525 Ile
Leu Cys Ala Phe Thr Leu Pro Glu Gly Ser Glu Glu Asp Phe Gln 530 535
540 Glu Phe Leu Lys Asn Val Gly Tyr Thr Phe Val Asp Glu Ser Asp Asn
545 550 555 560 Ile Phe Tyr Lys Lys Phe Leu Arg Ser 565
71716DNACandida glabrata 7atgataccca agctgctgtg tggtaacaca
ctgttgagtg catctgttac aacaagtagg 60tctgtctatg gcttatctac cagatatttt
actcaggatc tcgcaccttc attggttaaa 120ctgcattccg agttaaagcc
tgatgagctt cttactgata acacaccaga ctatgtgcgt 180ttggtgctaa
gatcatcggt ctatgatgtt ataaaggaat cgccaatctc acatggtgtt
240ggtctatcgt ctagactaaa cacaaatgtc caactgaaaa gagaagattt
actaccagtg 300ttctctttca agctgcgtgg tgcatacaac atgatagcga
agttagacga tactcagaga 360aatcaaggtg tcatcgcatg ttccgcaggt
aatcatgcac aaggtgtagc atatgccgct 420agacatttgg atattccagc
aactattgtc atgcctgtgt ctactccatc tataaaatat 480caaaatgtgt
cgagactggg ttcacaagtt gttctatatg gtaatgattt tgacgaagct
540aaagctgaat gtactaaact ggcagaagag cgtggtttga ctaacatccc
tccatttgat 600catccatatg tcattgctgg tcaaggaaca gttgcgatgg
aaatcttgag acaggtctat 660aactcaaata agatcggtgc tgtctttgtt
ccagttggtg gtggtgggtt gattgccggt 720gttggtgcct atttgaagag
agtcactcca cacatcaaga ttataggtgt ggaaacacat 780gatgcagcaa
ctttacacac atctcttcaa agaaataaaa gaacaaatct agctagcgtt
840ggtacttttg ctgatggtac ttctgtgcgt attattggtg aagaaacctt
tagagttgcc 900agagaagttg tcgatgaaat tgtattggtc aatactgatg
aaatttgtgc tgcggttaag 960gatgtctttg aggataccag aagtattgtt
gaaccatctg gtgctcttgc ggttgctggt 1020atgaagaagt atattactca
acttcatcca gaaatagatc actctaagca aacatatgtc 1080ccaattttgt
caggtgctaa tatgaacttc gatagattaa gatttgtttc tgagcgtgct
1140gtattaggtg aaggtaagga agtttttatg ctggttacca ttcctgacgt
tccaggctct 1200ttcaaaaaaa tgcagaaggt tattcatcca agagctgtta
ctgagttctg ttaccgttat 1260aatgaacatc gtcatgaatc ttctagtgag
gttccaaagg cctatatcta tacatctttc 1320agtgtggtag accgcgaaaa
ggagattaaa caagtaatgc agcaactgaa caccctcggt 1380tttgaagccg
tcgatatttc tgacaatgaa ttagcaaaat cacatggtag atatttagtt
1440ggtggtgcgt caaaggtccc aaatgaaaga attatttcgt tcgaattccc
agaaagacct 1500ggggccttaa ccagattctt ggcaggttta agcgagtctt
ggaatttgac attgttccat 1560tacagaaacc atggtgctga tattggtaaa
gtattggctg gtatttctgt gccacctaga 1620gaaaatttaa ctttccaaaa
attcttggaa gatttaggct ataagtacca agatgaaaca 1680gaaaatatgg
tatatcaaag actactgaaa tattaa 17168571PRTCandida glabrata 8Met Ile
Pro Lys Leu Leu Cys Gly Asn Thr Leu Leu Ser Ala Ser Val 1 5 10 15
Thr Thr Ser Arg Ser Val Tyr Gly Leu Ser Thr Arg Tyr Phe Thr Gln 20
25 30 Asp Leu Ala Pro Ser Leu Val Lys Leu His Ser Glu Leu Lys Pro
Asp 35 40 45 Glu Leu Leu Thr Asp Asn Thr Pro Asp Tyr Val Arg Leu
Val Leu Arg 50 55 60 Ser Ser Val Tyr Asp Val Ile Lys Glu Ser Pro
Ile Ser His Gly Val 65 70 75 80 Gly Leu Ser Ser Arg Leu Asn Thr Asn
Val Gln Leu Lys Arg Glu Asp 85 90 95 Leu Leu Pro Val Phe Ser Phe
Lys Leu Arg Gly Ala Tyr Asn Met Ile 100 105 110 Ala Lys Leu Asp Asp
Thr Gln Arg Asn Gln Gly Val Ile Ala Cys Ser 115 120 125 Ala Gly Asn
His Ala Gln Gly Val Ala Tyr Ala Ala Arg His Leu Asp 130 135 140 Ile
Pro Ala Thr Ile Val Met Pro Val Ser Thr Pro Ser Ile Lys Tyr 145 150
155 160 Gln Asn Val Ser Arg Leu Gly Ser Gln Val Val Leu Tyr Gly Asn
Asp 165 170 175 Phe Asp Glu Ala Lys Ala Glu Cys Thr Lys Leu Ala Glu
Glu Arg Gly 180 185 190 Leu Thr Asn Ile Pro Pro Phe Asp His Pro Tyr
Val Ile Ala Gly Gln 195 200 205 Gly Thr Val Ala Met Glu Ile Leu Arg
Gln Val Tyr Asn Ser Asn Lys 210 215 220 Ile Gly Ala Val Phe Val Pro
Val Gly Gly Gly Gly Leu Ile Ala Gly 225 230 235 240 Val Gly Ala Tyr
Leu Lys Arg Val Thr Pro His Ile Lys Ile Ile Gly 245 250 255 Val Glu
Thr His Asp Ala Ala Thr Leu His Thr Ser Leu Gln Arg Asn 260 265 270
Lys Arg Thr Asn Leu Ala Ser Val Gly Thr Phe Ala Asp Gly Thr Ser 275
280 285 Val Arg Ile Ile Gly Glu Glu Thr Phe Arg Val Ala Arg Glu Val
Val 290 295 300 Asp Glu Ile Val Leu Val Asn Thr Asp Glu Ile Cys Ala
Ala Val Lys 305 310 315 320 Asp Val Phe Glu Asp Thr Arg Ser Ile Val
Glu Pro Ser Gly Ala Leu 325 330 335 Ala Val Ala Gly Met Lys Lys Tyr
Ile Thr Gln Leu His Pro Glu Ile 340 345 350 Asp His Ser Lys Gln Thr
Tyr Val Pro Ile Leu Ser Gly Ala Asn Met 355 360 365 Asn Phe Asp Arg
Leu Arg Phe Val Ser Glu Arg Ala Val Leu Gly Glu 370 375 380 Gly Lys
Glu Val Phe Met Leu Val Thr Ile Pro Asp Val Pro Gly Ser 385 390 395
400 Phe Lys Lys Met Gln Lys Val Ile His Pro Arg Ala Val Thr Glu Phe
405 410 415 Cys Tyr Arg Tyr Asn Glu His Arg His Glu Ser Ser Ser Glu
Val Pro 420 425 430 Lys Ala Tyr Ile Tyr Thr Ser Phe Ser Val Val Asp
Arg Glu Lys Glu 435 440 445 Ile Lys Gln Val Met Gln Gln Leu Asn Thr
Leu Gly Phe Glu Ala Val 450 455 460 Asp Ile Ser Asp Asn Glu Leu Ala
Lys Ser His Gly Arg Tyr Leu Val 465 470 475 480 Gly Gly Ala Ser Lys
Val Pro Asn Glu Arg Ile Ile Ser Phe Glu Phe 485 490 495 Pro Glu Arg
Pro Gly Ala Leu Thr Arg Phe Leu Ala Gly Leu Ser Glu 500 505 510 Ser
Trp Asn Leu Thr Leu Phe His Tyr Arg Asn His Gly Ala Asp Ile 515 520
525 Gly Lys Val Leu Ala Gly Ile Ser Val Pro Pro Arg Glu Asn Leu Thr
530 535 540 Phe Gln Lys Phe Leu Glu Asp Leu Gly Tyr Lys Tyr Gln Asp
Glu Thr 545 550 555 560 Glu Asn Met Val Tyr Gln Arg Leu Leu Lys Tyr
565 570 91704DNAKluyveromyces lactis 9atgctacaat ctatagtgag
aactcctaga gttcttcgtg cttcaaatgc attaaaactt 60tctgttcgct gtgttagcac
ggaccagttc tctgataatt tgcagaggat gtactcccat 120ttgaaggctg
acgaacgatt ggaagatgga tctccagact acgtgcgttt aattttaagg
180tcttctgttt atgaagtcat tgaagagacc cccatttcac gtgcggtgtc
attgtcctct 240agactaaaca ctaacgttaa attgaaaaga gaggatttgt
tgccagtgtt ttccttcaag 300ctgcgtggtg cttataacat gattgccaag
ctagacgaaa cacagaagaa tgctggtgtt 360attgcgtgct ctgctggtaa
tcacgcacaa ggtgttgcct tttcaagtaa tcatatgaac 420attccagcta
ccattgtgat gcctgtttca acaccatcaa tcaaatatca aaacgtgtcg
480agattaggtg cccaagtggt tctatacggt gacgacttcg atgaagccaa
attggaatgt 540gcgaggttag ctgaagaacg tggtatgaca gatattccac
catttgatca tccttacgtt 600atcgctggtc aaggtactat tgccatggag
attctaagac aagtacaaaa tgggtctaac 660atcggagcag tgttctgtgc
cgtaggtggt ggtggtttga tttcaggtat tggttcatac 720ttgaagagaa
tcgcacctca tatcaaggtt attggtgtgg aaacttacga tgccgctacg
780ttagatgttt cattaaagaa cggtaaacgt accccattgc caagtgttgg
aacgttcgct 840gatggtacct ctgtgaggtt aatcggtgaa gaaacattcc
gtgtttgtca agacgtagtc 900gatgaagtta tcttggtgaa caccgatgaa
atctgtgctg ccgttaaaga tgtgtttgag 960gacacaagat caattgtcga
accaagtggt gctcttgctg ttgccggttt gaaaaaatat 1020gtctctcaac
tacaccctga aatagaccat tctaagaaga catacgttcc aattctttcc
1080ggtgccaaca tgaatttcga ccgtttaaga ttcgtctcag aacgtgctgt
attgggtgaa 1140ggtaaagaag tgtttatgtt ggtcaccatt ccagatactc
caggttcttt caagaagcta 1200cagaatgtga tccatccaag agctgtcact
gaattctcat accgttataa cgagcattgt 1260cacgaaaatg actccgatgt
accaaccgct tgtatctaca catcttttaa cgtcgttgac 1320cgtgaaaagg
aaatcaagca agtggttcaa caattgcatg ctttaggttt cgaagccgta
1380gatatctctg acaacgaaat ggccaagtct cacggtagat atttggtcgg
tggtgcttct 1440aaaattgaaa atgagaaagt cattgcattc gaattcccag
agagaccagg tgcactaact 1500aaattcttat caggattgaa cgtttcctgg
aacttgactt tattccatta cagaaaccat 1560ggcgctgata ttgggaaaat
tttggctggt atcagtgtgc ctccacaaga caacgaaatc 1620ttccaaaagt
tcttggacga tctaggatat aaatatcaag atgaaactga caatatggtt
1680taccagaagt ttttgaagta ctag 170410567PRTKluyveromyces lactis
10Met Leu Gln Ser Ile Val Arg Thr Pro Arg Val Leu Arg Ala Ser Asn 1
5 10 15 Ala Leu Lys Leu Ser Val Arg Cys Val Ser Thr Asp Gln Phe Ser
Asp 20 25 30 Asn Leu Gln Arg Met Tyr Ser His Leu Lys Ala Asp Glu
Arg Leu Glu 35 40 45 Asp Gly Ser Pro Asp Tyr Val Arg Leu Ile Leu
Arg Ser Ser Val Tyr 50 55 60 Glu Val Ile Glu Glu Thr Pro Ile Ser
Arg Ala Val Ser Leu Ser Ser 65 70 75 80 Arg Leu Asn Thr Asn Val Lys
Leu Lys Arg Glu Asp Leu Leu Pro Val 85 90 95 Phe Ser Phe Lys Leu
Arg Gly Ala Tyr Asn Met Ile Ala Lys Leu Asp 100 105 110 Glu Thr Gln
Lys Asn Ala Gly Val Ile Ala Cys Ser Ala Gly Asn His 115 120 125 Ala
Gln Gly Val Ala Phe Ser Ser Asn His Met Asn Ile Pro Ala Thr 130 135
140 Ile Val Met Pro Val Ser Thr Pro Ser Ile Lys Tyr Gln Asn Val Ser
145 150 155 160 Arg Leu Gly Ala Gln Val Val Leu Tyr Gly Asp Asp Phe
Asp Glu Ala 165 170 175 Lys Leu Glu Cys Ala Arg Leu Ala Glu Glu Arg
Gly Met Thr Asp Ile 180 185 190 Pro Pro Phe Asp His Pro Tyr Val Ile
Ala Gly Gln Gly Thr Ile Ala 195 200 205 Met Glu Ile Leu Arg Gln Val
Gln Asn Gly Ser Asn Ile Gly Ala Val 210 215 220 Phe Cys Ala Val Gly
Gly Gly Gly Leu Ile Ser Gly Ile Gly Ser Tyr 225 230 235 240 Leu Lys
Arg Ile Ala Pro His Ile Lys Val Ile Gly Val Glu Thr Tyr 245 250 255
Asp Ala Ala Thr Leu Asp Val Ser Leu Lys Asn Gly Lys Arg Thr Pro 260
265 270 Leu Pro Ser Val Gly Thr Phe Ala Asp Gly Thr Ser Val Arg Leu
Ile 275 280 285 Gly Glu Glu Thr Phe Arg Val Cys Gln Asp Val Val Asp
Glu Val Ile 290 295 300 Leu Val Asn Thr Asp Glu Ile Cys Ala Ala Val
Lys Asp Val Phe Glu 305 310 315 320 Asp Thr Arg Ser Ile Val Glu Pro
Ser Gly Ala Leu Ala Val Ala Gly 325 330 335 Leu Lys Lys Tyr Val Ser
Gln Leu His Pro Glu Ile Asp His Ser Lys 340 345 350 Lys Thr Tyr Val
Pro Ile Leu Ser Gly Ala Asn Met Asn Phe Asp Arg 355 360 365 Leu Arg
Phe Val Ser Glu Arg Ala Val Leu Gly Glu Gly Lys Glu Val 370 375 380
Phe Met Leu Val Thr Ile Pro Asp Thr Pro Gly Ser Phe Lys Lys Leu 385
390 395 400 Gln Asn Val Ile His Pro Arg Ala Val Thr Glu Phe Ser Tyr
Arg Tyr 405 410 415 Asn Glu His Cys His Glu Asn Asp Ser Asp Val Pro
Thr Ala Cys Ile 420 425 430 Tyr Thr Ser Phe Asn Val Val Asp Arg Glu
Lys Glu Ile Lys Gln Val 435 440 445 Val Gln Gln Leu His Ala Leu Gly
Phe Glu Ala Val Asp Ile Ser Asp 450 455 460 Asn Glu Met Ala Lys Ser
His Gly Arg Tyr Leu Val Gly Gly Ala Ser 465 470 475 480 Lys Ile Glu
Asn Glu Lys Val Ile Ala Phe Glu Phe Pro Glu Arg Pro 485 490 495 Gly
Ala Leu Thr Lys Phe Leu Ser Gly Leu Asn Val Ser Trp Asn Leu 500 505
510 Thr Leu Phe His Tyr Arg Asn His Gly Ala Asp Ile Gly Lys Ile Leu
515 520 525 Ala Gly Ile Ser Val Pro Pro Gln Asp Asn Glu Ile Phe Gln
Lys Phe 530 535 540 Leu Asp Asp Leu Gly Tyr Lys Tyr Gln Asp Glu Thr
Asp Asn Met Val 545 550 555 560 Tyr Gln Lys Phe Leu Lys Tyr 565
111590DNAYarrowia lipolytica 11atgtccgaac ccgactatct gaagctcatc
ttgaagagcc gcgtctacga cgtgtgcaag 60gaaacacctg tgacatctgc tcatggtctg
agcgagaagc tgggctgcaa agtgctgctc 120aagcgggaag atcttcagcc
ggttttctcg ttcaagctgc gaggagccta caacatgatt 180tcgcagctga
gtgacgagga aaagtggaag ggagtgattg cgtgtagcgc cggtaaccat
240gcccaaggag tcgccttttc agccaactat ctcaacattc cagcgactat
tgtcatgccg 300ttggccactc cttccatcaa gcacagtaat gtttctagac
taggtggcaa ggtggttttg 360cacggagacg attttgattc ggccaaggcc
cactgcaagc agctgtgtga gaaatatgga 420ctcacagata tccctccctt
tgatcacccc cacgtgattg caggccaggg aactattggt 480atggagattc
ttcgtcaggc gtcggacaac ctgaaggccg tgtttatctg tgttggaggc
540ggcggtctga ttgccggagt aggcgcttac atcaagcgga tccagcccga
tgtcaaaatc 600attgccgtgg agacctatga tgcatgtgct ctgaaacaga
gtctcatcaa gggcgaacgg 660gtgactctgc ctgaagtcgg tctgtttgcc
gatggagctg ctgtcaagct gtgtggcgag 720gagactttcc gactctgtcg
caagtacgtt gatggagttg tgcttgtgaa cacggacgag 780atctgcgccg
ctatcaaaga tgtatttgag gccactagat cggtggtgga gcctgctggt
840gctctgtcgg tggctggtct caagaagtac tgctccgacc cctcggccat
ttggtggtca 900cctgagtccg attccgcaaa ggccaatggt atccccacta
acgttgccat ctcagaaacc 960gacgagtatc tgtcaattct ctctggagcc
aacatgaact ttgaccggct tcgattcgtg 1020gccgaacgag ctatgcttgg
agaaggaacc gaagtcttca tggtcgtcac catccccgat 1080attcccggag
cgtttgaaaa gctgcacgag atcattctcc ccagagctgt caccgagttc
1140tcctacagaa agaagtccac tgctgagaac gaagacgcta acatttttgt
gtctttttca 1200gtcaaaaacc gacaagagga aattgcagac gtgctggaaa
agctgcaagc tgccggtatg 1260agcggagtcg acgtttcaga caacgaactg
gcaaagaccc acgctagata tctcgtggga 1320ggccagccag acgtgcctaa
tgagagactg ttccggttcg agttccctga acgacccaac 1380gcgctcaaaa
acttcctcgg aggtgtccag acaaagtgga atatcaccct gttccactac
1440agaaacaacg gcagtgatat tggaaagatt ctgacagcct tggacgtgcc
ggaaagcgac 1500aatgaggcgc tcaaggagtt tcttgagaag ctcaagtacc
cctttgtgga ggagacagac 1560aatgtggtgt acaagcagtt tatgaagtaa
159012529PRTYarrowia lipolytica 12Met Ser Glu Pro Asp Tyr Leu Lys
Leu Ile Leu Lys Ser Arg Val Tyr 1 5 10 15 Asp Val Cys Lys Glu Thr
Pro Val Thr Ser Ala His Gly Leu Ser Glu 20 25 30 Lys Leu Gly Cys
Lys Val Leu Leu Lys Arg Glu Asp Leu Gln Pro Val 35 40 45 Phe Ser
Phe Lys Leu Arg Gly Ala Tyr Asn Met Ile Ser Gln Leu Ser 50 55 60
Asp Glu Glu Lys Trp Lys Gly Val Ile Ala Cys Ser Ala Gly Asn His 65
70 75
80 Ala Gln Gly Val Ala Phe Ser Ala Asn Tyr Leu Asn Ile Pro Ala Thr
85 90 95 Ile Val Met Pro Leu Ala Thr Pro Ser Ile Lys His Ser Asn
Val Ser 100 105 110 Arg Leu Gly Gly Lys Val Val Leu His Gly Asp Asp
Phe Asp Ser Ala 115 120 125 Lys Ala His Cys Lys Gln Leu Cys Glu Lys
Tyr Gly Leu Thr Asp Ile 130 135 140 Pro Pro Phe Asp His Pro His Val
Ile Ala Gly Gln Gly Thr Ile Gly 145 150 155 160 Met Glu Ile Leu Arg
Gln Ala Ser Asp Asn Leu Lys Ala Val Phe Ile 165 170 175 Cys Val Gly
Gly Gly Gly Leu Ile Ala Gly Val Gly Ala Tyr Ile Lys 180 185 190 Arg
Ile Gln Pro Asp Val Lys Ile Ile Ala Val Glu Thr Tyr Asp Ala 195 200
205 Cys Ala Leu Lys Gln Ser Leu Ile Lys Gly Glu Arg Val Thr Leu Pro
210 215 220 Glu Val Gly Leu Phe Ala Asp Gly Ala Ala Val Lys Leu Cys
Gly Glu 225 230 235 240 Glu Thr Phe Arg Leu Cys Arg Lys Tyr Val Asp
Gly Val Val Leu Val 245 250 255 Asn Thr Asp Glu Ile Cys Ala Ala Ile
Lys Asp Val Phe Glu Ala Thr 260 265 270 Arg Ser Val Val Glu Pro Ala
Gly Ala Leu Ser Val Ala Gly Leu Lys 275 280 285 Lys Tyr Cys Ser Asp
Pro Ser Ala Ile Trp Trp Ser Pro Glu Ser Asp 290 295 300 Ser Ala Lys
Ala Asn Gly Ile Pro Thr Asn Val Ala Ile Ser Glu Thr 305 310 315 320
Asp Glu Tyr Leu Ser Ile Leu Ser Gly Ala Asn Met Asn Phe Asp Arg 325
330 335 Leu Arg Phe Val Ala Glu Arg Ala Met Leu Gly Glu Gly Thr Glu
Val 340 345 350 Phe Met Val Val Thr Ile Pro Asp Ile Pro Gly Ala Phe
Glu Lys Leu 355 360 365 His Glu Ile Ile Leu Pro Arg Ala Val Thr Glu
Phe Ser Tyr Arg Lys 370 375 380 Lys Ser Thr Ala Glu Asn Glu Asp Ala
Asn Ile Phe Val Ser Phe Ser 385 390 395 400 Val Lys Asn Arg Gln Glu
Glu Ile Ala Asp Val Leu Glu Lys Leu Gln 405 410 415 Ala Ala Gly Met
Ser Gly Val Asp Val Ser Asp Asn Glu Leu Ala Lys 420 425 430 Thr His
Ala Arg Tyr Leu Val Gly Gly Gln Pro Asp Val Pro Asn Glu 435 440 445
Arg Leu Phe Arg Phe Glu Phe Pro Glu Arg Pro Asn Ala Leu Lys Asn 450
455 460 Phe Leu Gly Gly Val Gln Thr Lys Trp Asn Ile Thr Leu Phe His
Tyr 465 470 475 480 Arg Asn Asn Gly Ser Asp Ile Gly Lys Ile Leu Thr
Ala Leu Asp Val 485 490 495 Pro Glu Ser Asp Asn Glu Ala Leu Lys Glu
Phe Leu Glu Lys Leu Lys 500 505 510 Tyr Pro Phe Val Glu Glu Thr Asp
Asn Val Val Tyr Lys Gln Phe Met 515 520 525 Lys 131620DNAPichia
stipitis 13atgtttttca gtagatctgg agaagttgaa aaatttccaa accttctcga
cgccgatttc 60aacgaagatg gtgatccaga ctacatcaaa ttgatcttga cttcacgagt
gtatgatgtt 120gtggaaaggg caggaacccc tctcacacat gccatcaatt
tgtcccataa gtgcaattca 180aacatctact tgaagagaga ggatttgctt
cctgtattct ctttcaaatt gcgtggagca 240tataatatga tttcacattt
gcattctaac tcaaagatgc cactttcggg tgtaatagct 300tgttctgctg
gtaaccatgc tcaaggtgta gcttactctg ccaacagatt gaaaattcct
360tccactatag ttatgcctac ggctacacct tctatcaagt ataccaatgt
ttcgagactt 420ggatcgcaag ttgttttgta tggtgacgac tttgactcgg
ccaagcaaga atgtgcccgt 480ttgagttcat tgaacaactt gacggatgtg
cctcctttcg accatcccta tgtcatcgct 540ggccagggta ccatagcatt
ggagatcacg agacagttgc gcttggataa gttgaacgca 600ttgtttgtcc
ctgttggtgg tggtggtctt attgctggtg tcgctgtcta cttgaagaag
660attgctcccc atgtgaagat cattggtgta gaaacaaacg atgctgatgc
cttgtaccag 720tcgctcaagg ctaaaaagct ggtggtactt gaccaagttg
gtatgtttgc tgacggaact 780gctgtcaagg tcttaggtaa agaaacctgg
agactctgtg aaaacttagt agacgaagtc 840gttaaggttt ctactgatga
gttgtgtgca gcaatcaagg atatctttga agacacaaga 900ctgattactg
aaccatccgg agccttgtct gtagccggct tgaagaagta cattgaacaa
960aatccagaca ttgaccacag aaacaagttc tatgtgccca tcttgagtgg
tgccaatatg 1020aacttcgaca gattgagatt cgtcagcgag agagctgttc
tcggtgaagg taaagaagtt 1080tcgttggtgg ttactattcc tgaaaagcct
ggtgaattcg ccaagttgca aagtatcatc 1140aatcctagag ccattacaga
attctcgtac aggtgtaatg gtgctgatgc caacatcttt 1200gtttccttca
atgttattga caaaaagaag gaattaaccc caattattga agacatgaac
1260aacaatgaac atggatacga agtagttgat atctctgaca atgaattagc
caagacccat 1320ggtcgttatt tggtcggcgg taagtcctct gaagaagttg
ccaatgaaag attatacagt 1380ttcgaatttc cagaaaagcc tggagcctta
ttcaacttct tacaagcttt gaaggctgat 1440tggaacatta ctttgtttca
ttacagaaat cacgggcacg acatcggcaa ggttttgtgt 1500ggttttacgc
ttcctgaagg aacagatgac gcagatttcc agtccttctt gaatgaactt
1560ggatacaagt tcaatgttga aaatgacaac gttgtctata agaagttctt
gagaagctga 162014539PRTPichia stipitis 14Met Phe Phe Ser Arg Ser
Gly Glu Val Glu Lys Phe Pro Asn Leu Leu 1 5 10 15 Asp Ala Asp Phe
Asn Glu Asp Gly Asp Pro Asp Tyr Ile Lys Leu Ile 20 25 30 Leu Thr
Ser Arg Val Tyr Asp Val Val Glu Arg Ala Gly Thr Pro Leu 35 40 45
Thr His Ala Ile Asn Leu Ser His Lys Cys Asn Ser Asn Ile Tyr Leu 50
55 60 Lys Arg Glu Asp Leu Leu Pro Val Phe Ser Phe Lys Leu Arg Gly
Ala 65 70 75 80 Tyr Asn Met Ile Ser His Leu His Ser Asn Ser Lys Met
Pro Leu Ser 85 90 95 Gly Val Ile Ala Cys Ser Ala Gly Asn His Ala
Gln Gly Val Ala Tyr 100 105 110 Ser Ala Asn Arg Leu Lys Ile Pro Ser
Thr Ile Val Met Pro Thr Ala 115 120 125 Thr Pro Ser Ile Lys Tyr Thr
Asn Val Ser Arg Leu Gly Ser Gln Val 130 135 140 Val Leu Tyr Gly Asp
Asp Phe Asp Ser Ala Lys Gln Glu Cys Ala Arg 145 150 155 160 Leu Ser
Ser Leu Asn Asn Leu Thr Asp Val Pro Pro Phe Asp His Pro 165 170 175
Tyr Val Ile Ala Gly Gln Gly Thr Ile Ala Leu Glu Ile Thr Arg Gln 180
185 190 Leu Arg Leu Asp Lys Leu Asn Ala Leu Phe Val Pro Val Gly Gly
Gly 195 200 205 Gly Leu Ile Ala Gly Val Ala Val Tyr Leu Lys Lys Ile
Ala Pro His 210 215 220 Val Lys Ile Ile Gly Val Glu Thr Asn Asp Ala
Asp Ala Leu Tyr Gln 225 230 235 240 Ser Leu Lys Ala Lys Lys Ser Val
Val Leu Asp Gln Val Gly Met Phe 245 250 255 Ala Asp Gly Thr Ala Val
Lys Val Leu Gly Lys Glu Thr Trp Arg Leu 260 265 270 Cys Glu Asn Leu
Val Asp Glu Val Val Lys Val Ser Thr Asp Glu Leu 275 280 285 Cys Ala
Ala Ile Lys Asp Ile Phe Glu Asp Thr Arg Ser Ile Thr Glu 290 295 300
Pro Ser Gly Ala Leu Ser Val Ala Gly Leu Lys Lys Tyr Ile Glu Gln 305
310 315 320 Asn Pro Asp Ile Asp His Arg Asn Lys Phe Tyr Val Pro Ile
Leu Ser 325 330 335 Gly Ala Asn Met Asn Phe Asp Arg Leu Arg Phe Val
Ser Glu Arg Ala 340 345 350 Val Leu Gly Glu Gly Lys Glu Val Ser Leu
Val Val Thr Ile Pro Glu 355 360 365 Lys Pro Gly Glu Phe Ala Lys Leu
Gln Ser Ile Ile Asn Pro Arg Ala 370 375 380 Ile Thr Glu Phe Ser Tyr
Arg Cys Asn Gly Ala Asp Ala Asn Ile Phe 385 390 395 400 Val Ser Phe
Asn Val Ile Asp Lys Lys Lys Glu Leu Thr Pro Ile Ile 405 410 415 Glu
Asp Met Asn Asn Asn Glu His Gly Tyr Glu Val Val Asp Ile Ser 420 425
430 Asp Asn Glu Leu Ala Lys Thr His Gly Arg Tyr Leu Val Gly Gly Lys
435 440 445 Ser Ser Glu Glu Val Ala Asn Glu Arg Leu Tyr Ser Phe Glu
Phe Pro 450 455 460 Glu Lys Pro Gly Ala Leu Phe Asn Phe Leu Gln Ala
Leu Lys Ala Asp 465 470 475 480 Trp Asn Ile Thr Leu Phe His Tyr Arg
Asn His Gly His Asp Ile Gly 485 490 495 Lys Val Leu Cys Gly Phe Thr
Leu Pro Glu Gly Thr Asp Asp Ala Asp 500 505 510 Phe Gln Ser Phe Leu
Asn Glu Leu Gly Tyr Lys Phe Asn Val Glu Asn 515 520 525 Asp Asn Val
Val Tyr Lys Lys Phe Leu Arg Ser 530 535 151182DNASaccharomyces
cerevisiae 15atgttgcaga gacattcctt gaagttgggg aaattctcca tcagaacact
cgctactggt 60gccccattag atgcatccaa actaaaaatt actagaaacc caaatccatc
caagccaaga 120ccaaatgaag aattagtgtt cggccagaca ttcaccgatc
atatgttgac cattccttgg 180tcagccaaag aagggtgggg cactccacac
atcaagcctt acggtaatct ttctcttgac 240ccatctgctt gtgtattcca
ttatgcattt gaattatttg aaggtttgaa agcctacaga 300actcctcaaa
atactatcac catgttccgt ccggataaga acatggcccg tatgaacaag
360tctgccgcta gaatttgttt gccaactttc gaatctgaag aattgatcaa
acttaccggg 420aaattgatcg aacaagataa acacttggtt cctcaaggta
atggttactc attatacatc 480agaccaacaa tgattggtac atccaagggt
ttaggtgttg gcactccctc cgaggctctt 540ctttatgtta ttacttctcc
agtcggtcct tattataaga ctggtttcaa agccgtacgt 600cttgaagcaa
cagactatgc tacaagagct tggccaggtg gtgttggcga caaaaaattg
660ggtgctaact atgccccatg catcttacct caactacaag ctgccaaaag
agggtaccaa 720caaaatctat ggttgttcgg cccagaaaag aacatcactg
aggttggtac tatgaacgtg 780ttcttcgttt tcctcaacaa agtcactggc
aagaaggaat tggttaccgc tccattagat 840ggtaccattt tagaaggtgt
taccagagac tctgttttaa cattggctcg tgacaaacta 900gatcctcaag
aatgggacat caacgagcgt tattacacta ttactgaagt cgccactaga
960gcaaaacaag gtgaactatt agaagccttc ggttctggta ctgctgctgt
cgtttcacct 1020atcaaggaaa ttggctggaa caacgaagat attcatgttc
cactattgcc tggtgaacaa 1080tgtggtgcat tgaccaagca agttgctcaa
tggattgctg atatccaata cggtagagtc 1140aattatggta actggtcaaa
aactgttgcc gacttgaact aa 118216393PRTSaccharomyces cerevisiae 16Met
Leu Gln Arg His Ser Leu Lys Leu Gly Lys Phe Ser Ile Arg Thr 1 5 10
15 Leu Ala Thr Gly Ala Pro Leu Asp Ala Ser Lys Leu Lys Ile Thr Arg
20 25 30 Asn Pro Asn Pro Ser Lys Pro Arg Pro Asn Glu Glu Leu Val
Phe Gly 35 40 45 Gln Thr Phe Thr Asp His Met Leu Thr Ile Pro Trp
Ser Ala Lys Glu 50 55 60 Gly Trp Gly Thr Pro His Ile Lys Pro Tyr
Gly Asn Leu Ser Leu Asp 65 70 75 80 Pro Ser Ala Cys Val Phe His Tyr
Ala Phe Glu Leu Phe Glu Gly Leu 85 90 95 Lys Ala Tyr Arg Thr Pro
Gln Asn Thr Ile Thr Met Phe Arg Pro Asp 100 105 110 Lys Asn Met Ala
Arg Met Asn Lys Ser Ala Ala Arg Ile Cys Leu Pro 115 120 125 Thr Phe
Glu Ser Glu Glu Leu Ile Lys Leu Thr Gly Lys Leu Ile Glu 130 135 140
Gln Asp Lys His Leu Val Pro Gln Gly Asn Gly Tyr Ser Leu Tyr Ile 145
150 155 160 Arg Pro Thr Met Ile Gly Thr Ser Lys Gly Leu Gly Val Gly
Thr Pro 165 170 175 Ser Glu Ala Leu Leu Tyr Val Ile Thr Ser Pro Val
Gly Pro Tyr Tyr 180 185 190 Lys Thr Gly Phe Lys Ala Val Arg Leu Glu
Ala Thr Asp Tyr Ala Thr 195 200 205 Arg Ala Trp Pro Gly Gly Val Gly
Asp Lys Lys Leu Gly Ala Asn Tyr 210 215 220 Ala Pro Cys Ile Leu Pro
Gln Leu Gln Ala Ala Lys Arg Gly Tyr Gln 225 230 235 240 Gln Asn Leu
Trp Leu Phe Gly Pro Glu Lys Asn Ile Thr Glu Val Gly 245 250 255 Thr
Met Asn Val Phe Phe Val Phe Leu Asn Lys Val Thr Gly Lys Lys 260 265
270 Glu Leu Val Thr Ala Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr
275 280 285 Arg Asp Ser Val Leu Thr Leu Ala Arg Asp Lys Leu Asp Pro
Gln Glu 290 295 300 Trp Asp Ile Asn Glu Arg Tyr Tyr Thr Ile Thr Glu
Val Ala Thr Arg 305 310 315 320 Ala Lys Gln Gly Glu Leu Leu Glu Ala
Phe Gly Ser Gly Thr Ala Ala 325 330 335 Val Val Ser Pro Ile Lys Glu
Ile Gly Trp Asn Asn Glu Asp Ile His 340 345 350 Val Pro Leu Leu Pro
Gly Glu Gln Cys Gly Ala Leu Thr Lys Gln Val 355 360 365 Ala Gln Trp
Ile Ala Asp Ile Gln Tyr Gly Arg Val Asn Tyr Gly Asn 370 375 380 Trp
Ser Lys Thr Val Ala Asp Leu Asn 385 390
171143DNASchizosaccharomyces pombe 17atggttcaaa ctgctgctct
ccatggccca aagcccatgg atagctccca tataaaagtt 60actaatgtta aggagcttaa
acctttgccc gaatggaaga gtttgaagtt tggtgagaat 120tttactgatc
atatgcttat tatgaaatgg aacagagaaa agggttggag tactcctgag
180atcgttccat ttggtaaact ttgctttcac cctgcttcct ccgttttcca
ttatggtttt 240gagtgctttg aaggcatgaa agctttccgt gacgaaaagg
gtgtcccacg tcttttccgt 300cccatcaaga atgctgagcg tatgctttca
actggtactc gtatatctct tccttccttc 360gaccctgctg agcttgctga
aattatcaga aagttcgtcg ctcacgaaaa ccgttgggtc 420cctgatcagc
gtggttactc tttgtacatt cgtcctactt tcattggtac tgatgaagcc
480ttaggtgtcc accattgtga caacgctatg ctttatgtta ttgcctctcc
cgttggcccc 540tactacagct ctggtttcaa ggccgttaag ctttgttgct
ccgaagaatc cgttcgtgct 600tggcctggcg gtactggtca ctacaagctt
ggtggtaact atgctcctag tgttttgcct 660caaaaagagg ctgccaagaa
ggggtatgct cagattctct ggctttatgg agacgaggac 720tacattactg
aggttggtac tatgaactgc tttactgttt ggattaacaa gaatggcgaa
780aaagaaatca ttactgcccc tcttgacggt atgatcttac ctggtgtcac
tcgtgattct 840attttggaaa tttgccgtga acgtctcgca cctaaaggct
ggaagattac tgagggcaag 900tattccatga aagaggttgc tcaagcttct
aaggaaggtc gccttttgga agtctttgga 960gctggtactg ctgcccttgt
ttcccccgtc aaggctatta actacaaggg tactgagtat 1020gaaattccca
tgcctgaggg tcaggaagct ggtcccatca cttctgaaat cagcaaatgg
1080attttggata tccaatacgg caaggaacct aacaaccctt ggagcgttcc
tgctttgcct 1140taa 114318380PRTSchizosaccharomyces pombe 18Met Val
Gln Thr Ala Ala Leu His Gly Pro Lys Pro Met Asp Ser Ser 1 5 10 15
His Ile Lys Val Thr Asn Val Lys Glu Leu Lys Pro Leu Pro Glu Trp 20
25 30 Lys Ser Leu Lys Phe Gly Glu Asn Phe Thr Asp His Met Leu Ile
Met 35 40 45 Lys Trp Asn Arg Glu Lys Gly Trp Ser Thr Pro Glu Ile
Val Pro Phe 50 55 60 Gly Lys Leu Cys Phe His Pro Ala Ser Ser Val
Phe His Tyr Gly Phe 65 70 75 80 Glu Cys Phe Glu Gly Met Lys Ala Phe
Arg Asp Glu Lys Gly Val Pro 85 90 95 Arg Leu Phe Arg Pro Ile Lys
Asn Ala Glu Arg Met Leu Ser Thr Gly 100 105 110 Thr Arg Ile Ser Leu
Pro Ser Phe Asp Pro Ala Glu Leu Ala Glu Ile 115 120 125 Ile Arg Lys
Phe Val Ala His Glu Asn Arg Trp Val Pro Asp Gln Arg 130 135 140 Gly
Tyr Ser Leu Tyr Ile Arg Pro Thr Phe Ile Gly Thr Asp Glu Ala 145 150
155 160 Leu Gly Val His His Cys Asp Asn Ala Met Leu Tyr Val Ile Ala
Ser 165 170 175 Pro Val Gly Pro Tyr Tyr Ser Ser Gly Phe Lys Ala Val
Lys Leu Cys 180 185 190 Cys Ser Glu Glu Ser Val Arg Ala Trp Pro Gly
Gly Thr Gly His Tyr 195 200 205 Lys Leu Gly Gly Asn Tyr Ala Pro Ser
Val Leu Pro Gln Lys Glu Ala 210 215 220 Ala Lys Lys Gly Tyr Ala Gln
Ile Leu Trp Leu Tyr Gly Asp Glu Asp 225 230 235 240 Tyr Ile Thr Glu
Val Gly Thr Met Asn Cys Phe Thr Val Trp Ile Asn 245 250 255 Lys Asn
Gly Glu Lys Glu Ile Ile Thr Ala Pro Leu Asp Gly Met Ile 260 265 270
Leu Pro Gly Val Thr Arg Asp Ser Ile Leu Glu Ile Cys Arg Glu Arg 275
280
285 Leu Ala Pro Lys Gly Trp Lys Ile Thr Glu Gly Lys Tyr Ser Met Lys
290 295 300 Glu Val Ala Gln Ala Ser Lys Glu Gly Arg Leu Leu Glu Val
Phe Gly 305 310 315 320 Ala Gly Thr Ala Ala Leu Val Ser Pro Val Lys
Ala Ile Asn Tyr Lys 325 330 335 Gly Thr Glu Tyr Glu Ile Pro Met Pro
Glu Gly Gln Glu Ala Gly Pro 340 345 350 Ile Thr Ser Glu Ile Ser Lys
Trp Ile Leu Asp Ile Gln Tyr Gly Lys 355 360 365 Glu Pro Asn Asn Pro
Trp Ser Val Pro Ala Leu Pro 370 375 380 191110DNACandida albicans
19atgtcagctc cattagacgc cagtaaattg gaaatcacta aaactaccaa accaagtgaa
60ccattaccaa aagaagaatt ggttttcggt aaatcattca ctgaccatat cttagaagtt
120gaatggactg ctgaaaaagg atggggtgtt ccaactatta aaccatacca
caacttttcc 180cttgatccag ccacctgtgt tttacattat tcttttgagt
tatttgaagg tttaaaggca 240taccgtgata gcaatggtaa aatcagaact
tttagaccag acaaaaatat ggaaagaatg 300aatagatcag ctaaaagagc
tgcattacct acatttgatg gtgaagaatt tatcaaatta 360gttgatcaat
ttttgttgat tgaagaaaga tttgttccaa ctggttacgg atattcactt
420tacttgagac caactttaat tggtacttca attgggttag gtgtcagtgc
accaactaaa 480gcattattat atcttattgc ttcacctgtt ggtccatatt
tcagtggtgg tttcaaacca 540gtgtctttgg aagccacaga ttacgccgta
agagcttggc caaaaggtgt tggttcttat 600aaattgggtg caaactatgt
gtcttgtatt gaaccacaaa tggaagctgc caagagaggt 660cattcccaaa
atttgtggtt atttggtgaa gaaggttata ttactgaagt gggtgctatg
720aatgtttttt ttgcattcaa gaatgccgat ggcactaaag aattggtgac
tccgccattg 780gatggtatga tcttgccagg tgtcactcgt gattctactt
tagaattggc taaaagcaaa 840ttaccaagtg attggactgt caatgaaaga
aaattgacta ttcatgaagt taaagaaaga 900gctgctaaag gtgaattagt
tgaagctttc ggtactggta ccgctgctat tgtttcacca 960attgacaaca
ttgaattcca aggcgaacaa attaaggttc cagtttctgc tggtagttcc
1020ggagaaatag ctttgaagat caatgattgg ataaaggcta ttcaatatgg
tgatgaaagt 1080tttaaaaact ggtctagagt agcccaatag 111020369PRTCandida
albicans 20Met Ser Ala Pro Leu Asp Ala Ser Lys Leu Glu Ile Thr Lys
Thr Thr 1 5 10 15 Lys Pro Ser Glu Pro Leu Pro Lys Glu Glu Leu Val
Phe Gly Lys Ser 20 25 30 Phe Thr Asp His Ile Leu Glu Val Glu Trp
Thr Ala Glu Lys Gly Trp 35 40 45 Gly Val Pro Thr Ile Lys Pro Tyr
His Asn Phe Ser Leu Asp Pro Ala 50 55 60 Thr Cys Val Leu His Tyr
Ser Phe Glu Leu Phe Glu Gly Leu Lys Ala 65 70 75 80 Tyr Arg Asp Ser
Asn Gly Lys Ile Arg Thr Phe Arg Pro Asp Lys Asn 85 90 95 Met Glu
Arg Met Asn Arg Ser Ala Lys Arg Ala Ala Leu Pro Thr Phe 100 105 110
Asp Gly Glu Glu Phe Ile Lys Leu Val Asp Gln Phe Leu Leu Ile Glu 115
120 125 Glu Arg Phe Val Pro Thr Gly Tyr Gly Tyr Ser Leu Tyr Leu Arg
Pro 130 135 140 Thr Leu Ile Gly Thr Ser Ile Gly Leu Gly Val Ser Ala
Pro Thr Lys 145 150 155 160 Ala Leu Leu Tyr Leu Ile Ala Ser Pro Val
Gly Pro Tyr Phe Ser Gly 165 170 175 Gly Phe Lys Pro Val Ser Leu Glu
Ala Thr Asp Tyr Ala Val Arg Ala 180 185 190 Trp Pro Lys Gly Val Gly
Ser Tyr Lys Leu Gly Ala Asn Tyr Val Ser 195 200 205 Cys Ile Glu Pro
Gln Met Glu Ala Ala Lys Arg Gly His Ser Gln Asn 210 215 220 Leu Trp
Leu Phe Gly Glu Glu Gly Tyr Ile Thr Glu Val Gly Ala Met 225 230 235
240 Asn Val Phe Phe Ala Phe Lys Asn Ala Asp Gly Thr Lys Glu Leu Val
245 250 255 Thr Pro Pro Leu Asp Gly Met Ile Leu Pro Gly Val Thr Arg
Asp Ser 260 265 270 Thr Leu Glu Leu Ala Lys Ser Lys Leu Pro Ser Asp
Trp Thr Val Asn 275 280 285 Glu Arg Lys Leu Thr Ile His Glu Val Lys
Glu Arg Ala Ala Lys Gly 290 295 300 Glu Leu Val Glu Ala Phe Gly Thr
Gly Thr Ala Ala Ile Val Ser Pro 305 310 315 320 Ile Asp Asn Ile Glu
Phe Gln Gly Glu Gln Ile Lys Val Pro Val Ser 325 330 335 Ala Gly Ser
Ser Gly Glu Ile Ala Leu Lys Ile Asn Asp Trp Ile Lys 340 345 350 Ala
Ile Gln Tyr Gly Asp Glu Ser Phe Lys Asn Trp Ser Arg Val Ala 355 360
365 Gln 211224DNAKluyveromyces lactis 21atgaactaca ttggactacg
gaattgtgca agagctgttt ccagcagagt ttccattcca 60tcaagaggta ttaagagtca
tattttaaca agttatagag ccatgtcctt agacgcatcc 120aaggttaaaa
tcaccaaggt cgaaacccca tcgaagccac gtccaaacga tgagttggtt
180ttcggtcaaa ctttcactga ccatatgtta accatcgaat ggacagctga
aaacggttgg 240ggtgtcccag agattaaacc atacgggaac ttgtcgttag
atccatcctc gtgtgtgttc 300cactatgctt tcgaattgtt cgaaggtttg
aaggcgtaca gaaccccaga caacaagatc 360agcatgttcc gtgctgataa
gaatatggaa cgtatgaaca agtcagcagc cagaatctgt 420ttgccatctt
ttaattcgga tgagttgatc aagttgatcg gtaagttgat cgaacaagac
480aagcatttgg tgcctcaagg tcaaggttac tccttgtaca tcagacctac
aatgattggt 540actactaacg gattgggtgt tggtactcca gacagagctt
tgttgtatgt gatcacatct 600ccagtgggac catattacaa gactgggttc
aaagccgtga gattggaagc tacggattat 660gctactagag cttggccagg
tggtgttggt gacaagaagc ttggtgccaa ctacgcacca 720tgtatcttgc
ctcaattgca agctgctgaa cgtggttacc aacaaaactt gtggttgttc
780ggtccagaaa agaacatcac tgaagtcggt actatgaacg tcttcttcgt
gttcaaggac 840tccaagaccg gcaagaagga attggttact gctccattgg
acggtaccat tttggaaggt 900gtcactagag actctattct acaattggcc
agagaaaact tgaactctga cgagtggatc 960gtctctgaac gttactacac
tatcaccgaa gtggaagaaa gagctgccaa gggcgaattg 1020gtcgaagcgt
tcggttccgg taccgctgct gtcgtgtctc caatcaagga aatcggctgg
1080aacggtcacg atatccaagt gccattgttg cctggtgaac aatgtggtcc
attgaccaag 1140caagtggctg aatggattgc cgatatccaa tatggcagaa
aagaacacaa gggatggtcc 1200cgtatcgttg ctgacttgaa ctaa
122422407PRTKluyveromyces lactis 22Met Asn Tyr Ile Gly Leu Arg Asn
Cys Ala Arg Ala Val Ser Ser Arg 1 5 10 15 Val Ser Ile Pro Ser Arg
Gly Ile Lys Ser His Ile Leu Thr Ser Tyr 20 25 30 Arg Ala Met Ser
Leu Asp Ala Ser Lys Val Lys Ile Thr Lys Val Glu 35 40 45 Thr Pro
Ser Lys Pro Arg Pro Asn Asp Glu Leu Val Phe Gly Gln Thr 50 55 60
Phe Thr Asp His Met Leu Thr Ile Glu Trp Thr Ala Glu Asn Gly Trp 65
70 75 80 Gly Val Pro Glu Ile Lys Pro Tyr Gly Asn Leu Ser Leu Asp
Pro Ser 85 90 95 Ser Cys Val Phe His Tyr Ala Phe Glu Leu Phe Glu
Gly Leu Lys Ala 100 105 110 Tyr Arg Thr Pro Asp Asn Lys Ile Ser Met
Phe Arg Ala Asp Lys Asn 115 120 125 Met Glu Arg Met Asn Lys Ser Ala
Ala Arg Ile Cys Leu Pro Ser Phe 130 135 140 Asn Ser Asp Glu Leu Ile
Lys Leu Ile Gly Lys Leu Ile Glu Gln Asp 145 150 155 160 Lys His Leu
Val Pro Gln Gly Gln Gly Tyr Ser Leu Tyr Ile Arg Pro 165 170 175 Thr
Met Ile Gly Thr Thr Asn Gly Leu Gly Val Gly Thr Pro Asp Arg 180 185
190 Ala Leu Leu Tyr Val Ile Thr Ser Pro Val Gly Pro Tyr Tyr Lys Thr
195 200 205 Gly Phe Lys Ala Val Arg Leu Glu Ala Thr Asp Tyr Ala Thr
Arg Ala 210 215 220 Trp Pro Gly Gly Val Gly Asp Lys Lys Leu Gly Ala
Asn Tyr Ala Pro 225 230 235 240 Cys Ile Leu Pro Gln Leu Gln Ala Ala
Glu Arg Gly Tyr Gln Gln Asn 245 250 255 Leu Trp Leu Phe Gly Pro Glu
Lys Asn Ile Thr Glu Val Gly Thr Met 260 265 270 Asn Val Phe Phe Val
Phe Lys Asp Ser Lys Thr Gly Lys Lys Glu Leu 275 280 285 Val Thr Ala
Pro Leu Asp Gly Thr Ile Leu Glu Gly Val Thr Arg Asp 290 295 300 Ser
Ile Leu Gln Leu Ala Arg Glu Asn Leu Asn Ser Asp Glu Trp Ile 305 310
315 320 Val Ser Glu Arg Tyr Tyr Thr Ile Thr Glu Val Glu Glu Arg Ala
Ala 325 330 335 Lys Gly Glu Leu Val Glu Ala Phe Gly Ser Gly Thr Ala
Ala Val Val 340 345 350 Ser Pro Ile Lys Glu Ile Gly Trp Asn Gly His
Asp Ile Gln Val Pro 355 360 365 Leu Leu Pro Gly Glu Gln Cys Gly Pro
Leu Thr Lys Gln Val Ala Glu 370 375 380 Trp Ile Ala Asp Ile Gln Tyr
Gly Arg Lys Glu His Lys Gly Trp Ser 385 390 395 400 Arg Ile Val Ala
Asp Leu Asn 405 231167DNAYarrowia lipolytica 23atgcttcgaa
acaacttgag atcgctttcg cgggccttca gcacctcctc catgcgtctg 60ggcgccggaa
tggacgcctc caagctccag atcaccaaga ccaagtcccc caaggaaaag
120caggccccca aggatctcat tttcggccat accttcaccg accacatgct
gactgtcgag 180tggactgcca aggacggctg ggctgctccc cagatcaccc
cctacggtcc tcttgagctg 240gatccctccg ccgtcgtcct gcactatgcc
tttgagtgtt tcgagggcct caaggcttac 300aaggacgagt ctggaaacgt
gcgtctgttc cgagtcgaca agaacatgca ccgaatgaac 360acatcggccg
agcgaatctg cctgcccgag tttgatggcg ccgaggctgc caagctgatt
420ggccaattgg ccaagcttga ttccgcttgg atccccgagg gacgaggcta
ctccatgtac 480ctccgacctt ctctgattgg aaccaccgcc gctctcggcg
tcggaacccc cgataaggcg 540ctcttttacg tcattgcatc ccccgtcggc
ccctactacc ctaccggatt caaggccgtc 600aagctggagg ctactgacta
cgctgtccga gcctggcctg gaggagtcgg aaacaagaag 660ctgggagcca
actacgctcc ctgtatcaag cctcagcagc aggccgcttc tcgaggctac
720cagcagaacc tgtggctgtt tggcgacgag ggcaacatca ccgaggtcgg
taccatgaac 780gccttctttg tgtttgagcg aaacggcaag aaggagcttg
tcactgctcc tttggacggt 840actattctcg agggtgtcac tcgagactcc
attctggagc tggctcgaga acgattgcct 900tctgctgact ggatcgtttc
cgagcgatac tgcactatta aagaggtcgc ggaggctgcc 960gagaagggcg
agcttgttga ggcctttgga gctggtactg ccgctgttgt ctcgcctatc
1020aaggagattg gatggggaga gaagactatt aacattcctc tccagcctgg
caaggaggcc 1080ggtaagctga ctgagactgt taatgagtgg attggagata
tccagtacgg taaggatgaa 1140tacaagggat ggtctaaggt ggtctaa
116724388PRTYarrowia lipolytica 24Met Leu Arg Asn Asn Leu Arg Ser
Leu Ser Arg Ala Phe Ser Thr Ser 1 5 10 15 Ser Met Arg Leu Gly Ala
Gly Met Asp Ala Ser Lys Leu Gln Ile Thr 20 25 30 Lys Thr Lys Ser
Pro Lys Glu Lys Gln Ala Pro Lys Asp Leu Ile Phe 35 40 45 Gly His
Thr Phe Thr Asp His Met Leu Thr Val Glu Trp Thr Ala Lys 50 55 60
Asp Gly Trp Ala Ala Pro Gln Ile Thr Pro Tyr Gly Pro Leu Glu Leu 65
70 75 80 Asp Pro Ser Ala Val Val Leu His Tyr Ala Phe Glu Cys Phe
Glu Gly 85 90 95 Leu Lys Ala Tyr Lys Asp Glu Ser Gly Asn Val Arg
Leu Phe Arg Val 100 105 110 Asp Lys Asn Met His Arg Met Asn Thr Ser
Ala Glu Arg Ile Cys Leu 115 120 125 Pro Glu Phe Asp Gly Ala Glu Ala
Ala Lys Leu Ile Gly Gln Leu Ala 130 135 140 Lys Leu Asp Ser Ala Trp
Ile Pro Glu Gly Arg Gly Tyr Ser Met Tyr 145 150 155 160 Leu Arg Pro
Ser Leu Ile Gly Thr Thr Ala Ala Leu Gly Val Gly Thr 165 170 175 Pro
Asp Lys Ala Leu Phe Tyr Val Ile Ala Ser Pro Val Gly Pro Tyr 180 185
190 Tyr Pro Thr Gly Phe Lys Ala Val Lys Leu Glu Ala Thr Asp Tyr Ala
195 200 205 Val Arg Ala Trp Pro Gly Gly Val Gly Asn Lys Lys Leu Gly
Ala Asn 210 215 220 Tyr Ala Pro Cys Ile Lys Pro Gln Gln Gln Ala Ala
Ser Arg Gly Tyr 225 230 235 240 Gln Gln Asn Leu Trp Leu Phe Gly Asp
Glu Gly Asn Ile Thr Glu Val 245 250 255 Gly Thr Met Asn Ala Phe Phe
Val Phe Glu Arg Asn Gly Lys Lys Glu 260 265 270 Leu Val Thr Ala Pro
Leu Asp Gly Thr Ile Leu Glu Gly Val Thr Arg 275 280 285 Asp Ser Ile
Leu Glu Leu Ala Arg Glu Arg Leu Pro Ser Ala Asp Trp 290 295 300 Ile
Val Ser Glu Arg Tyr Cys Thr Ile Lys Glu Val Ala Glu Ala Ala 305 310
315 320 Glu Lys Gly Glu Leu Val Glu Ala Phe Gly Ala Gly Thr Ala Ala
Val 325 330 335 Val Ser Pro Ile Lys Glu Ile Gly Trp Gly Glu Lys Thr
Ile Asn Ile 340 345 350 Pro Leu Gln Pro Gly Lys Glu Ala Gly Lys Leu
Thr Glu Thr Val Asn 355 360 365 Glu Trp Ile Gly Asp Ile Gln Tyr Gly
Lys Asp Glu Tyr Lys Gly Trp 370 375 380 Ser Lys Val Val 385
251113DNAPichia stipitis 25atgtctgctc cattagatgc ctccaagctt
gtgatccaca agaccaccac ccccaaggaa 60aagttgccca acgataagtt ggtcttcggc
aagaccttca ccgaccacat gttggaaatc 120gaatggactg ctcaagccgg
ctggggcact cctaccattt ctccctacca caagttgtct 180ttggatcctt
ctactgtcgt attgcactac gcttttgagt tatttgaagg tatgaaagct
240tacagagaca ctgataacaa catcagaacc ttcagaggtg acaagaacat
ggacagaatg 300aacaagtccg ctgacagaat cgccttacca acctttgatg
gtgaagagtt gatgaagctc 360attgatcagt tcttgctcgt agacgaaagc
tttgttccac aaggtgctgg ctactccctt 420tatttaagac caactatgat
cggaaccacc gagtcattgg gtgtaggtac gccagataag 480gcactcttgt
atgttattgc atctcccgtt ggcccttact atggtactgg cttcaagcct
540gtttccttag aagccactga ctatgctgtt agagcctggc caggtggtgt
aggtaacaga 600aagttgggtg ccaactatgc tccttgtgtc agacctcagt
tagaggctgc taagagaggt 660taccaacaaa acttgtggtt attcggagag
gaaggctaca ttaccgaagt cggtaccatg 720aacgctttct ttgtattcaa
gaacgctgac ggcaccaagg agttggccac tgctcctttg 780gatggtacca
tcttggaagg tgtcaccaga gactcgatct tggaactcac cagagaaaga
840ttgccaaaga acgaatgggt agtgtccgaa cgtaagttca ccattggtga
agttgaagaa 900agagctgcca agggtgagtt gatcgaagca tttggtgctg
gtactgctgc tgttgtttct 960cctatcaagt ctattggctg gaagggcaag
gaaatcgaag ttcctttggc tgctggcgat 1020tccggcgaat tgaccgctca
agttgctgag tggatcagaa agatccaata cggtgaagaa 1080cagtacaaaa
actggtccag agttgctcaa tag 111326370PRTPichia stipitis 26Met Ser Ala
Pro Leu Asp Ala Ser Lys Leu Val Ile His Lys Thr Thr 1 5 10 15 Thr
Pro Lys Glu Lys Leu Pro Asn Asp Lys Leu Val Phe Gly Lys Thr 20 25
30 Phe Thr Asp His Met Leu Glu Ile Glu Trp Thr Ala Gln Ala Gly Trp
35 40 45 Gly Thr Pro Thr Ile Ser Pro Tyr His Lys Leu Ser Leu Asp
Pro Ser 50 55 60 Thr Val Val Leu His Tyr Ala Phe Glu Leu Phe Glu
Gly Met Lys Ala 65 70 75 80 Tyr Arg Asp Thr Asp Asn Asn Ile Arg Thr
Phe Arg Gly Asp Lys Asn 85 90 95 Met Asp Arg Met Asn Lys Ser Ala
Asp Arg Ile Ala Leu Pro Thr Phe 100 105 110 Asp Gly Glu Glu Leu Met
Lys Leu Ile Asp Gln Phe Leu Leu Val Asp 115 120 125 Glu Ser Phe Val
Pro Gln Gly Ala Gly Tyr Ser Leu Tyr Leu Arg Pro 130 135 140 Thr Met
Ile Gly Thr Thr Glu Ser Leu Gly Val Gly Thr Pro Asp Lys 145 150 155
160 Ala Leu Leu Tyr Val Ile Ala Ser Pro Val Gly Pro Tyr Tyr Gly Thr
165 170 175 Gly Phe Lys Pro Val Ser Leu Glu Ala Thr Asp Tyr Ala Val
Arg Ala 180 185 190 Trp Pro Gly Gly Val Gly Asn Arg Lys Leu Gly Ala
Asn Tyr Ala Pro 195 200 205 Cys Val Arg Pro Gln Leu Glu Ala Ala Lys
Arg Gly Tyr Gln Gln Asn 210 215 220 Leu Trp Leu Phe Gly Glu Glu Gly
Tyr Ile Thr Glu Val Gly Thr Met 225 230 235 240 Asn Ala Phe Phe Val
Phe Lys Asn Ala Asp Gly Thr Lys Glu Leu Ala 245 250 255 Thr Ala Pro
Leu Asp Gly Thr Ile Leu Glu Gly Val Thr Arg Asp Ser 260 265 270 Ile
Leu Glu Leu Thr Arg Glu Arg Leu Pro Lys Asn Glu Trp Val Val 275
280
285 Ser Glu Arg Lys Phe Thr Ile Gly Glu Val Glu Glu Arg Ala Ala Lys
290 295 300 Gly Glu Leu Ile Glu Ala Phe Gly Ala Gly Thr Ala Ala Val
Val Ser 305 310 315 320 Pro Ile Lys Ser Ile Gly Trp Lys Gly Lys Glu
Ile Glu Val Pro Leu 325 330 335 Ala Ala Gly Asp Ser Gly Glu Leu Thr
Ala Gln Val Ala Glu Trp Ile 340 345 350 Arg Lys Ile Gln Tyr Gly Glu
Glu Gln Tyr Lys Asn Trp Ser Arg Val 355 360 365 Ala Gln 370
271860DNASaccharomyces cerevisiae 27atggttaaag agagtattat
tgctcttgct gagcatgcgg cctccagagc ctcaagagtt 60attcctccag tgaagctagc
ctataaaaat atgcttaagg acccttcctc caagtacaag 120ccatttaacg
ctccaaagct atctaataga aagtggccgg ataaccggat cacgagggct
180cctcgttggt tatcaacaga tttgagagat ggtaaccaat ctctgccgga
tcccatgtca 240gtggaacaaa agaaagaata ctttcacaag ctggtcaata
ttgggttcaa agaaatcgag 300gtttccttcc cctctgcatc tcaaacagat
ttcgacttca ctagatatgc tgtagaaaac 360gccccagacg atgttagtat
tcaatgtctt gtccaatcta gagaacactt gattaagaga 420acggtggaag
cattaacagg tgctaaaaag gctactatac atacttactt ggcaacaagt
480gatatgttcc gtgaaattgt ttttaatatg tctagagagg aagctatttc
caaggcagta 540gaggccacca aactagttag gaaactaact aaggatgacc
cttcccaaca agccactcgt 600tggtcctatg agttttcccc cgaatgtttc
agtgatactc caggtgaatt tgctgtagaa 660atttgcgaag ctgttaagaa
ggcttgggaa cctaccgagg aaaatccaat cattttcaac 720ttacctgcta
ccgtagaagt tgcctctcca aatgtttatg ctgatcagat tgaatacttc
780gctacccata ttactgagcg tgagaaggtt tgcatctcta cacattgtca
caatgaccgt 840ggttgcggtg tcgccgccac agagttaggt atgcttgcag
gtgccgaccg tgtagaagga 900tgtctctttg gtaatggtga acgtacaggt
aatgtggact tggttactgt tgctatgaat 960atgtataccc aaggtgtttc
tcctaatttg gatttctctg acttgacctc tgtcctagat 1020gtggttgagc
gttgtaataa gatcccagta tcgcaaagag caccatacgg cggtgacttg
1080gtcgtttgtg ccttttccgg ttctcaccaa gacgccatta agaagggttt
caacttacaa 1140aacaagaagc gtgctcaagg tgaaactcaa tggagaatcc
catacttgcc attggatcca 1200aaggacattg gccgtgatta cgaagctgtc
atcagagtca actctcagtc tggtaaaggt 1260ggtgccgctt gggttatttt
gagatctttg ggtttggatc taccaagaaa catgcaaatc 1320gaattttcta
gcgccgttca agaccatgct gactccttgg gtagagaact aaaatcagat
1380gagatttcca agttattcaa agaggcttac aactacaatg acgaacagta
ccaagctatt 1440agtttagtca attataatgt tgaaaaattc ggcactgaac
gtagagtgtt cactggtcaa 1500gtcaaagtag gcgaccagat cgtcgatatt
gaaggtacag gtaatggtcc aatctcttct 1560ttggtcgacg ccctatcaaa
cttgttgaac gtgagatttg ccgtagcaaa ctacacagag 1620cattctctag
gttctggttc ttctacgcaa gctgcttctt acatccatct atcgtatagg
1680cgtaatgccg acaacgaaaa ggcctacaaa tggggtgtag gtgtctccga
agatgtcggt 1740gattcttcag tgagagccat ctttgccacc attaacaata
ttatccattc tggtgatgtg 1800tccattccat ctttggccga ggtcgaaggt
aagaatgctg cggcatctgg ctctgcataa 186028619PRTSaccharomyces
cerevisiae 28Met Val Lys Glu Ser Ile Ile Ala Leu Ala Glu His Ala
Ala Ser Arg 1 5 10 15 Ala Ser Arg Val Ile Pro Pro Val Lys Leu Ala
Tyr Lys Asn Met Leu 20 25 30 Lys Asp Pro Ser Ser Lys Tyr Lys Pro
Phe Asn Ala Pro Lys Leu Ser 35 40 45 Asn Arg Lys Trp Pro Asp Asn
Arg Ile Thr Arg Ala Pro Arg Trp Leu 50 55 60 Ser Thr Asp Leu Arg
Asp Gly Asn Gln Ser Leu Pro Asp Pro Met Ser 65 70 75 80 Val Glu Gln
Lys Lys Glu Tyr Phe His Lys Leu Val Asn Ile Gly Phe 85 90 95 Lys
Glu Ile Glu Val Ser Phe Pro Ser Ala Ser Gln Thr Asp Phe Asp 100 105
110 Phe Thr Arg Tyr Ala Val Glu Asn Ala Pro Asp Asp Val Ser Ile Gln
115 120 125 Cys Leu Val Gln Ser Arg Glu His Leu Ile Lys Arg Thr Val
Glu Ala 130 135 140 Leu Thr Gly Ala Lys Lys Ala Thr Ile His Thr Tyr
Leu Ala Thr Ser 145 150 155 160 Asp Met Phe Arg Glu Ile Val Phe Asn
Met Ser Arg Glu Glu Ala Ile 165 170 175 Ser Lys Ala Val Glu Ala Thr
Lys Leu Val Arg Lys Leu Thr Lys Asp 180 185 190 Asp Pro Ser Gln Gln
Ala Thr Arg Trp Ser Tyr Glu Phe Ser Pro Glu 195 200 205 Cys Phe Ser
Asp Thr Pro Gly Glu Phe Ala Val Glu Ile Cys Glu Ala 210 215 220 Val
Lys Lys Ala Trp Glu Pro Thr Glu Glu Asn Pro Ile Ile Phe Asn 225 230
235 240 Leu Pro Ala Thr Val Glu Val Ala Ser Pro Asn Val Tyr Ala Asp
Gln 245 250 255 Ile Glu Tyr Phe Ala Thr His Ile Thr Glu Arg Glu Lys
Val Cys Ile 260 265 270 Ser Thr His Cys His Asn Asp Arg Gly Cys Gly
Val Ala Ala Thr Glu 275 280 285 Leu Gly Met Leu Ala Gly Ala Asp Arg
Val Glu Gly Cys Leu Phe Gly 290 295 300 Asn Gly Glu Arg Thr Gly Asn
Val Asp Leu Val Thr Val Ala Met Asn 305 310 315 320 Met Tyr Thr Gln
Gly Val Ser Pro Asn Leu Asp Phe Ser Asp Leu Thr 325 330 335 Ser Val
Leu Asp Val Val Glu Arg Cys Asn Lys Ile Pro Val Ser Gln 340 345 350
Arg Ala Pro Tyr Gly Gly Asp Leu Val Val Cys Ala Phe Ser Gly Ser 355
360 365 His Gln Asp Ala Ile Lys Lys Gly Phe Asn Leu Gln Asn Lys Lys
Arg 370 375 380 Ala Gln Gly Glu Thr Gln Trp Arg Ile Pro Tyr Leu Pro
Leu Asp Pro 385 390 395 400 Lys Asp Ile Gly Arg Asp Tyr Glu Ala Val
Ile Arg Val Asn Ser Gln 405 410 415 Ser Gly Lys Gly Gly Ala Ala Trp
Val Ile Leu Arg Ser Leu Gly Leu 420 425 430 Asp Leu Pro Arg Asn Met
Gln Ile Glu Phe Ser Ser Ala Val Gln Asp 435 440 445 His Ala Asp Ser
Leu Gly Arg Glu Leu Lys Ser Asp Glu Ile Ser Lys 450 455 460 Leu Phe
Lys Glu Ala Tyr Asn Tyr Asn Asp Glu Gln Tyr Gln Ala Ile 465 470 475
480 Ser Leu Val Asn Tyr Asn Val Glu Lys Phe Gly Thr Glu Arg Arg Val
485 490 495 Phe Thr Gly Gln Val Lys Val Gly Asp Gln Ile Val Asp Ile
Glu Gly 500 505 510 Thr Gly Asn Gly Pro Ile Ser Ser Leu Val Asp Ala
Leu Ser Asn Leu 515 520 525 Leu Asn Val Arg Phe Ala Val Ala Asn Tyr
Thr Glu His Ser Leu Gly 530 535 540 Ser Gly Ser Ser Thr Gln Ala Ala
Ser Tyr Ile His Leu Ser Tyr Arg 545 550 555 560 Arg Asn Ala Asp Asn
Glu Lys Ala Tyr Lys Trp Gly Val Gly Val Ser 565 570 575 Glu Asp Val
Gly Asp Ser Ser Val Arg Ala Ile Phe Ala Thr Ile Asn 580 585 590 Asn
Ile Ile His Ser Gly Asp Val Ser Ile Pro Ser Leu Ala Glu Val 595 600
605 Glu Gly Lys Asn Ala Ala Ala Ser Gly Ser Ala 610 615
291755DNASchizosaccharomyces pombe 29atgaaatcta cttttgaggc
tgctggccgc gttgccaaag ggatgctcaa ggatccctcc 60aaaaagtata agccatttaa
aggaattcaa ctacccaacc gtcaatggcc aaacaaggtt 120ttgacgaaag
ctccacgctg gctttctacg gacttgcgtg atggtaatca ggctttaccc
180gatcctatga atgggcagga gaaattgaga tattttaaat tgctttgcag
tattggcttc 240aaagaaattg aggttggttt cccaagtgct tctcaaactg
attttgcatt tgttcgtcat 300ctgattgaaa cgccaggttt gattcctgac
gatgttacta tttctgccct tactccttct 360cgtgagcctt tgatcctacg
tacgattgag gctcttcgag gcgctaagaa tgccactgtt 420cacttgtata
atgcctgttc tcctcttttc cgtgaagttg tcttccgcaa cagtaagcaa
480gaaacattgg atttagccat caaaggctca aaaatcgtaa cagctgctac
gaaaaatgct 540cttgaatcga aggaaaccaa ctggggattt gaatattctc
ctgaaacttt ttcagacacc 600gaaccagact ttgctttgga agtttgtgaa
gctgtcaagg gtatgtggaa accttctgct 660gcccaaccta ttatcttcaa
tcttcctgcc actgtcgaaa tgtctacgcc caacacatat 720gctgacttaa
ttgagtactt ttccactaac attagtgaac gtgaaaaagt ctgtgtttct
780ctccatcccc ataacgaccg tggtactgct gtcgcagcag ctgaacttgg
tcaacttgcc 840ggaggtgacc gtattgaggg ctgtttgttt ggcaatggtg
aacgtactgg taatgtagac 900ttggttactt tggctttcaa cttgtatacc
caaggtgttt ctcctaacct cgatttctcc 960aagttggatg aaatcattcg
tattactgaa gactgtaaca agataaacgt tcatccccgt 1020catccttatg
ctggcaatct tgtctttacc gccttttctg gttctcatca agatgccatt
1080tctaagggtt tgaaggctta cgatgagcgt aaagctgtcg atcctgtttg
gaaagtccct 1140tacttgcctt tggatcccca tgatgtcaat tccgagtatg
ctgctattat ccgcgttaac 1200tctcaatctg gcaagggtgg tgtcgcatat
ctgttgaaga ccaactgtgg tctcgattta 1260cctcgtgctt tgcaagttga
atttggtagt attgttaagg attatagcga cacaaaagga 1320aaggagctta
gcattggtga gatcagcgac ctgttttata ccacatatta cctcgaattt
1380cccggccgtt tctctgtaaa cgactacact ctttctagca acggacctca
aagcaaatgt 1440attaaatgcg ttgttgacat caagggtgaa aagaaagata
ctccttcgcg ggttgtgatc 1500gagggtgttg gaaatggacc tttgtcggca
ttggttgatg ctttacgccg tcagttcaat 1560atttcatttg acattggtca
atactctgaa catgctattg gttctggtaa cggcgtcaaa 1620gctgcttctt
atgttgagat cattttcaat aacacttctt tctggggtgt tggtattgat
1680gctgacgtta cctctgccgg attaaaggct gtcatgtcag gcgttagtcg
tgcctcccgc 1740gcatttgcta agtaa 175530584PRTSchizosaccharomyces
pombe 30Met Lys Ser Thr Phe Glu Ala Ala Gly Arg Val Ala Lys Gly Met
Leu 1 5 10 15 Lys Asp Pro Ser Lys Lys Tyr Lys Pro Phe Lys Gly Ile
Gln Leu Pro 20 25 30 Asn Arg Gln Trp Pro Asn Lys Val Leu Thr Lys
Ala Pro Arg Trp Leu 35 40 45 Ser Thr Asp Leu Arg Asp Gly Asn Gln
Ala Leu Pro Asp Pro Met Asn 50 55 60 Gly Gln Glu Lys Leu Arg Tyr
Phe Lys Leu Leu Cys Ser Ile Gly Phe 65 70 75 80 Lys Glu Ile Glu Val
Gly Phe Pro Ser Ala Ser Gln Thr Asp Phe Ala 85 90 95 Phe Val Arg
His Leu Ile Glu Thr Pro Gly Leu Ile Pro Asp Asp Val 100 105 110 Thr
Ile Ser Ala Leu Thr Pro Ser Arg Glu Pro Leu Ile Leu Arg Thr 115 120
125 Ile Glu Ala Leu Arg Gly Ala Lys Asn Ala Thr Val His Leu Tyr Asn
130 135 140 Ala Cys Ser Pro Leu Phe Arg Glu Val Val Phe Arg Asn Ser
Lys Gln 145 150 155 160 Glu Thr Leu Asp Leu Ala Ile Lys Gly Ser Lys
Ile Val Thr Ala Ala 165 170 175 Thr Lys Asn Ala Leu Glu Ser Lys Glu
Thr Asn Trp Gly Phe Glu Tyr 180 185 190 Ser Pro Glu Thr Phe Ser Asp
Thr Glu Pro Asp Phe Ala Leu Glu Val 195 200 205 Cys Glu Ala Val Lys
Gly Met Trp Lys Pro Ser Ala Ala Gln Pro Ile 210 215 220 Ile Phe Asn
Leu Pro Ala Thr Val Glu Met Ser Thr Pro Asn Thr Tyr 225 230 235 240
Ala Asp Leu Ile Glu Tyr Phe Ser Thr Asn Ile Ser Glu Arg Glu Lys 245
250 255 Val Cys Val Ser Leu His Pro His Asn Asp Arg Gly Thr Ala Val
Ala 260 265 270 Ala Ala Glu Leu Gly Gln Leu Ala Gly Gly Asp Arg Ile
Glu Gly Cys 275 280 285 Leu Phe Gly Asn Gly Glu Arg Thr Gly Asn Val
Asp Leu Val Thr Leu 290 295 300 Ala Phe Asn Leu Tyr Thr Gln Gly Val
Ser Pro Asn Leu Asp Phe Ser 305 310 315 320 Lys Leu Asp Glu Ile Ile
Arg Ile Thr Glu Asp Cys Asn Lys Ile Asn 325 330 335 Val His Pro Arg
His Pro Tyr Ala Gly Asn Leu Val Phe Thr Ala Phe 340 345 350 Ser Gly
Ser His Gln Asp Ala Ile Ser Lys Gly Leu Lys Ala Tyr Asp 355 360 365
Glu Arg Lys Ala Val Asp Pro Val Trp Lys Val Pro Tyr Leu Pro Leu 370
375 380 Asp Pro His Asp Val Asn Ser Glu Tyr Ala Ala Ile Ile Arg Val
Asn 385 390 395 400 Ser Gln Ser Gly Lys Gly Gly Val Ala Tyr Leu Leu
Lys Thr Asn Cys 405 410 415 Gly Leu Asp Leu Pro Arg Ala Leu Gln Val
Glu Phe Gly Ser Ile Val 420 425 430 Lys Asp Tyr Ser Asp Thr Lys Gly
Lys Glu Leu Ser Ile Gly Glu Ile 435 440 445 Ser Asp Leu Phe Tyr Thr
Thr Tyr Tyr Leu Glu Phe Pro Gly Arg Phe 450 455 460 Ser Val Asn Asp
Tyr Thr Leu Ser Ser Asn Gly Pro Gln Ser Lys Cys 465 470 475 480 Ile
Lys Cys Val Val Asp Ile Lys Gly Glu Lys Lys Asp Thr Pro Ser 485 490
495 Arg Val Val Ile Glu Gly Val Gly Asn Gly Pro Leu Ser Ala Leu Val
500 505 510 Asp Ala Leu Arg Arg Gln Phe Asn Ile Ser Phe Asp Ile Gly
Gln Tyr 515 520 525 Ser Glu His Ala Ile Gly Ser Gly Asn Gly Val Lys
Ala Ala Ser Tyr 530 535 540 Val Glu Ile Ile Phe Asn Asn Thr Ser Phe
Trp Gly Val Gly Ile Asp 545 550 555 560 Ala Asp Val Thr Ser Ala Gly
Leu Lys Ala Val Met Ser Gly Val Ser 565 570 575 Arg Ala Ser Arg Ala
Phe Ala Lys 580 31 1257DNASchizosaccharomyces pombe 31atgtctgtgt
ccgaagctaa tggtactgag accatcaagc ctcctatgaa tggaaaccct 60tatggtccca
acccatctga ttttctttca cgtgtcaata acttttccat tattgagtct
120actcttcgtg aaggtgagca attcgcaaac gcttttttcg acaccgagaa
gaaaattcaa 180attgctaagg cattggacaa ctttggtgtc gattacattg
aattgacttc tcccgtggct 240tctgagcagt cccgccaaga ttgcgaagct
atttgcaaat tgggcttaaa gtgtaaaatt 300ttaactcata ttcgctgtca
tatggatgac gctcgtgtcg ctgttgagac tggagttgat 360ggtgttgatg
ttgttatcgg aacttctcaa tatcttcgca aatattccca tggaaaggac
420atgacttaca ttattgacag cgctaccgaa gttatcaact ttgtcaagag
caagggtatt 480gaagtccgct tttcatctga ggattctttc cgttctgatc
ttgtcgatct cctttctctc 540tacaaggctg tagacaagat tggcgtcaac
cgtgttggta ttgctgacac cgttggttgc 600gctactcctc gccaagtcta
cgatcttatt cgtaccttac gtggtgttgt ctcttgtgat 660attgaatgtc
attttcacaa tgacactggt atggctattg ctaatgccta ttgcgcattg
720gaagctggtg ctacccatat cgatacttcc attcttggta ttggtgagcg
taatggtatt 780actcctcttg gtgccttgtt ggctcgtatg tatgtcaccg
atagggaata cattacccac 840aaatacaagc ttaaccagtt acgtgagctt
gaaaaccttg tcgctgatgc cgttgaagtt 900caaattcctt tcaacaatta
cattaccgga atgtgtgctt ttacccataa ggctggtatc 960catgctaaag
ctattctcgc taacccttct acatatgaaa ttcttaagcc cgaggacttt
1020ggcatgagtc gttatgttca tgttggctct cgtttgactg gttggaatgc
catcaaatct 1080cgtgctgagc agcttaacct tcatcttact gatgcccaag
ccaaggaact taccgttcgc 1140atcaagaaat tggctgatgt ccgtacttta
gccatggatg atgttgatcg tgttctacgt 1200gaataccatg ctgacttgag
tgatgctgat agaatcacca aagaagcgtc tgcttaa
125732418PRTSchizosaccharomyces pombe 32Met Ser Val Ser Glu Ala Asn
Gly Thr Glu Thr Ile Lys Pro Pro Met 1 5 10 15 Asn Gly Asn Pro Tyr
Gly Pro Asn Pro Ser Asp Phe Leu Ser Arg Val 20 25 30 Asn Asn Phe
Ser Ile Ile Glu Ser Thr Leu Arg Glu Gly Glu Gln Phe 35 40 45 Ala
Asn Ala Phe Phe Asp Thr Glu Lys Lys Ile Gln Ile Ala Lys Ala 50 55
60 Leu Asp Asn Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser Pro Val Ala
65 70 75 80 Ser Glu Gln Ser Arg Gln Asp Cys Glu Ala Ile Cys Lys Leu
Gly Leu 85 90 95 Lys Cys Lys Ile Leu Thr His Ile Arg Cys His Met
Asp Asp Ala Arg 100 105 110 Val Ala Val Glu Thr Gly Val Asp Gly Val
Asp Val Val Ile Gly Thr 115 120 125 Ser Gln Tyr Leu Arg Lys Tyr Ser
His Gly Lys Asp Met Thr Tyr Ile 130 135 140 Ile Asp Ser Ala Thr Glu
Val Ile Asn Phe Val Lys Ser Lys Gly Ile 145 150 155 160 Glu Val Arg
Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp Leu Val Asp 165 170 175 Leu
Leu Ser Leu Tyr Lys Ala Val Asp Lys Ile Gly Val Asn Arg Val 180 185
190 Gly Ile Ala Asp Thr Val Gly Cys Ala Thr Pro Arg Gln Val Tyr Asp
195 200 205 Leu Ile Arg Thr Leu Arg Gly Val Val Ser Cys Asp Ile Glu
Cys His 210 215 220 Phe His Asn Asp Thr Gly Met Ala Ile Ala Asn Ala
Tyr Cys Ala Leu 225
230 235 240 Glu Ala Gly Ala Thr His Ile Asp Thr Ser Ile Leu Gly Ile
Gly Glu 245 250 255 Arg Asn Gly Ile Thr Pro Leu Gly Ala Leu Leu Ala
Arg Met Tyr Val 260 265 270 Thr Asp Arg Glu Tyr Ile Thr His Lys Tyr
Lys Leu Asn Gln Leu Arg 275 280 285 Glu Leu Glu Asn Leu Val Ala Asp
Ala Val Glu Val Gln Ile Pro Phe 290 295 300 Asn Asn Tyr Ile Thr Gly
Met Cys Ala Phe Thr His Lys Ala Gly Ile 305 310 315 320 His Ala Lys
Ala Ile Leu Ala Asn Pro Ser Thr Tyr Glu Ile Leu Lys 325 330 335 Pro
Glu Asp Phe Gly Met Ser Arg Tyr Val His Val Gly Ser Arg Leu 340 345
350 Thr Gly Trp Asn Ala Ile Lys Ser Arg Ala Glu Gln Leu Asn Leu His
355 360 365 Leu Thr Asp Ala Gln Ala Lys Glu Leu Thr Val Arg Ile Lys
Lys Leu 370 375 380 Ala Asp Val Arg Thr Leu Ala Met Asp Asp Val Asp
Arg Val Leu Arg 385 390 395 400 Glu Tyr His Ala Asp Leu Ser Asp Ala
Asp Arg Ile Thr Lys Glu Ala 405 410 415 Ser Ala 331740DNACandida
albicans 33atgcaaaagg ttttccaaag atgggtatct agaatacccc cagttaagct
ccaatataag 60aatatgctta gagacccttc caaaaaatac tctccaccaa aacagatcaa
cttgcccaat 120agaacttggc ccaccaaagt aatcactaaa gctccccgct
ggctttccac tgatttaaga 180gacggtaacc agtccttgcc agatccaatg
tcggttccag aaaaaaaaga atacttccat 240aaattaattg atattgggtt
taaagaaatc gaagtttcgt tcccctctgc ttcgcaaact 300gattttgatt
tcacccgata cgccgttgaa aatgcgccag atgatgtaac tattcaagtc
360ttgacccaat ctcgtgaacc attgatcaga agaacagtgg aatcggtaaa
aggggccaag 420cgtgctacca ttcatacata tttggcaacc tctgatgtat
tccgtgaagt tgttttcggt 480atgagcaaac aagacgctat agacaaggcc
attgaaacta caaaattagt gagatcatta 540actaaagatg accctaacat
gcaagacact gaatggaatt tggagttttc tccagagtgt 600ttctcagata
cgccagttga atttgccgtt gagatttgtg aagccgttaa aaaagcttgg
660gaaccaacag tggaaaaccc aatgatcttc aatttgcctg ccacagttga
agttgctggt 720cctaatgttt atgctgatca gattgaatac ttttgtcaaa
acataactga acgtgaaaag 780attattgtct ccacccatac tcataatgac
cgtggctgtg gtgtcgctgc taccgaattg 840ggtatgttgg ctggtgccga
tagagtggaa ggttgtgtgt ttggaaacgg tgaaagaacc 900ggtaatgttg
acttggtcac ggtggcattg aacttgtaca cccaaggtat tgcgccaaat
960ttggactttt ccgatatcga gagcattatt gaggttagtg aacgttgtaa
taaaatcccg 1020gtgcccgcaa gatcacctta cggtggctca cttgtggtgt
gtgccttcag tggatctcat 1080caagacgcca ttaaaaaggg ttttgctaaa
caaaagggag acaaatgggc tatcccatac 1140ttgccattag atccaaaaga
tattggcaga acttacgaag ccgtgattag agtcaactcc 1200caatcaggta
aaggtggtgc tgcctgggtc atccttagat ctttgggatt ggacttgcca
1260agacacttac aagttgcctt ttcaggattg gtgcaaaaca ctgctgacct
gttgggtaga 1320gaattgaagg ttgatgaaat tgtcaacttg ttcaacgaac
aatacttggt gagtgcccct 1380ttaagcattc aggattttga aatcaccaag
aataaaaacg atgaaagaga aattgttgct 1440caattaaatg atggcatcac
cattaaaggt caaggtaatg gtcctatctc tgcttttatt 1500gatgcaattt
ctaacaagtt cggtgttttg tttgaagttg taaactatca agaacattct
1560ttgggaggtg gttctagtag taaggcagca acttatatcg aattatcata
tgttaatgcc 1620aatggtgaaa aagttactag atggggttgt ggtatcaatc
acgatgtgtc acaagcctca 1680atcgaagcca ttcttagtgt tgtaaactct
ttgattaaaa agaatgaatt aactgtatag 174034579PRTCandida albicans 34Met
Gln Lys Val Phe Gln Arg Trp Val Ser Arg Ile Pro Pro Val Lys 1 5 10
15 Leu Gln Tyr Lys Asn Met Leu Arg Asp Pro Ser Lys Lys Tyr Ser Pro
20 25 30 Pro Lys Gln Ile Asn Leu Pro Asn Arg Thr Trp Pro Thr Lys
Val Ile 35 40 45 Thr Lys Ala Pro Arg Trp Leu Ser Thr Asp Leu Arg
Asp Gly Asn Gln 50 55 60 Ser Leu Pro Asp Pro Met Ser Val Pro Glu
Lys Lys Glu Tyr Phe His 65 70 75 80 Lys Leu Ile Asp Ile Gly Phe Lys
Glu Ile Glu Val Ser Phe Pro Ser 85 90 95 Ala Ser Gln Thr Asp Phe
Asp Phe Thr Arg Tyr Ala Val Glu Asn Ala 100 105 110 Pro Asp Asp Val
Thr Ile Gln Val Leu Thr Gln Ser Arg Glu Pro Leu 115 120 125 Ile Arg
Arg Thr Val Glu Ser Val Lys Gly Ala Lys Arg Ala Thr Ile 130 135 140
His Thr Tyr Leu Ala Thr Ser Asp Val Phe Arg Glu Val Val Phe Gly 145
150 155 160 Met Ser Lys Gln Asp Ala Ile Asp Lys Ala Ile Glu Thr Thr
Lys Leu 165 170 175 Val Arg Ser Leu Thr Lys Asp Asp Pro Asn Met Gln
Asp Thr Glu Trp 180 185 190 Asn Leu Glu Phe Ser Pro Glu Cys Phe Ser
Asp Thr Pro Val Glu Phe 195 200 205 Ala Val Glu Ile Cys Glu Ala Val
Lys Lys Ala Trp Glu Pro Thr Val 210 215 220 Glu Asn Pro Met Ile Phe
Asn Leu Pro Ala Thr Val Glu Val Ala Gly 225 230 235 240 Pro Asn Val
Tyr Ala Asp Gln Ile Glu Tyr Phe Cys Gln Asn Ile Thr 245 250 255 Glu
Arg Glu Lys Ile Ile Val Ser Thr His Thr His Asn Asp Arg Gly 260 265
270 Cys Gly Val Ala Ala Thr Glu Leu Gly Met Leu Ala Gly Ala Asp Arg
275 280 285 Val Glu Gly Cys Val Phe Gly Asn Gly Glu Arg Thr Gly Asn
Val Asp 290 295 300 Leu Val Thr Val Ala Leu Asn Leu Tyr Thr Gln Gly
Ile Ala Pro Asn 305 310 315 320 Leu Asp Phe Ser Asp Ile Glu Ser Ile
Ile Glu Val Ser Glu Arg Cys 325 330 335 Asn Lys Ile Pro Val Pro Ala
Arg Ser Pro Tyr Gly Gly Ser Leu Val 340 345 350 Val Cys Ala Phe Ser
Gly Ser His Gln Asp Ala Ile Lys Lys Gly Phe 355 360 365 Ala Lys Gln
Lys Gly Asp Lys Trp Ala Ile Pro Tyr Leu Pro Leu Asp 370 375 380 Pro
Lys Asp Ile Gly Arg Thr Tyr Glu Ala Val Ile Arg Val Asn Ser 385 390
395 400 Gln Ser Gly Lys Gly Gly Ala Ala Trp Val Ile Leu Arg Ser Leu
Gly 405 410 415 Leu Asp Leu Pro Arg His Leu Gln Val Ala Phe Ser Gly
Leu Val Gln 420 425 430 Asn Thr Ala Asp Ser Leu Gly Arg Glu Leu Lys
Val Asp Glu Ile Val 435 440 445 Asn Leu Phe Asn Glu Gln Tyr Leu Val
Ser Ala Pro Leu Ser Ile Gln 450 455 460 Asp Phe Glu Ile Thr Lys Asn
Lys Asn Asp Glu Arg Glu Ile Val Ala 465 470 475 480 Gln Leu Asn Asp
Gly Ile Thr Ile Lys Gly Gln Gly Asn Gly Pro Ile 485 490 495 Ser Ala
Phe Ile Asp Ala Ile Ser Asn Lys Phe Gly Val Leu Phe Glu 500 505 510
Val Val Asn Tyr Gln Glu His Ser Leu Gly Gly Gly Ser Ser Ser Lys 515
520 525 Ala Ala Thr Tyr Ile Glu Leu Ser Tyr Val Asn Ala Asn Gly Glu
Lys 530 535 540 Val Thr Arg Trp Gly Cys Gly Ile Asn His Asp Val Ser
Gln Ala Ser 545 550 555 560 Ile Glu Ala Ile Leu Ser Val Val Asn Ser
Leu Ile Lys Lys Asn Glu 565 570 575 Leu Thr Val 351722DNACandida
albicans 35atgcctatgt taaaagatcc ctcagtgaaa tataagaagt ttccaaatgt
caatttgcca 60aaccgtcaat ggccatcaag aagcttggat aaaccaccaa gatggttatc
tactgatttg 120agagatggta accaatcatt acctgatcca atgtcgatct
ctgaaaagaa agaatatttc 180aagaaattgg ttgatatagg attcaaagaa
atcgaagttg ccttcccctc agcctctcaa 240attgatttcg atttcactag
atttgccgtt gaaactgccc ctgaagatgt ttcgattcaa 300gttctttctc
catgtcgtcc cgaattgatt ggtagaactg ttgaatcttt gaaaggtgct
360aaaagagcaa ctgtccacat atatcttgcc acttctgatt gttttagaaa
tgttgtgttt 420ggactttcca aagaagaatc aaaggcctta gctgtgaaat
gtaccaaatt ggtgagacaa 480ttaactaaag atgatccttc aactgccggt
acagattggg attttgaatt ttctccagaa 540actttttctg acacagattt
ggattatgct gttgaagtat gtgaagcagt caaagaagcc 600tgggggccaa
cagaagataa accaattata tttaatttgc cagcaactgt tgaaatggcc
660actcctaaca tatatgctga tcaaattgaa tattttgcca ctcatattac
tgaccgtgaa 720acagtttgta tttcattgca tcctcacaat gatagagggt
gtagtgttgc tgctgccgaa 780ttaggtcaat tagctggtgc tgacagagtt
gaaggttgtc ttttcggtaa tggtgaaaga 840accggtaatg ttgatttagt
cactttagca ttgaacttgt atacccaggg ggtatcacca 900aaattggact
tttctgattt gaattcggtc attgatatag ttgaaaaatg caacaaaatt
960cctgttcatg ctagagctcc atacggaggg tctcttgttg tttgtgcctt
tagtggatct 1020catcaagatg ccatcaaaaa ggggttcctg gctcacgaaa
agaaaaaaga aaaagcggga 1080ggcaaagaag ttcattggca attaccttat
ttaccattgg atccagaaga tattggaaga 1140acatacgagg ctattattag
agtgaattct caatctggta aaggtggttc tgcttgggtg 1200atcttgagaa
atttggaatt agatttacct cgtggtttac aaattgcctt ctctaaagtg
1260gttcaagcac gtgctgaagt taaaggtcaa gaattaacta acgaagaatt
atgtgagtta 1320ttcaagcaag aatatttcat tgattatgat gatgaagccc
cagaacaata ctttaaatta 1380gtagattact cgatatcgac accaagcaaa
ggaatcaagg aaatccaagc tgatattgaa 1440gtcgatggta aagtcatttc
tatcaaaggt gaaggtaatg gtcaattatc tgcctttaat 1500aatgccattg
ctaaatattt gaatattgat attgacgtga aacattatca cgaacattcc
1560cttggtgaag attcaaaagc ccgtgccgcc acttatattg aagtcttggt
cgataaaaaa 1620gttgcaagat ggggtgtggg tattcatact gatgtttctc
aagcttcatt cttatctttg 1680atatctattt tgaatggttt gcataaaaat
aaaaacattt aa 172236573PRTCandida albicans 36Met Pro Met Leu Lys
Asp Pro Ser Val Lys Tyr Lys Lys Phe Pro Asn 1 5 10 15 Val Asn Leu
Pro Asn Arg Gln Trp Pro Ser Arg Ser Leu Asp Lys Pro 20 25 30 Pro
Arg Trp Leu Ser Thr Asp Leu Arg Asp Gly Asn Gln Ser Leu Pro 35 40
45 Asp Pro Met Ser Ile Ser Glu Lys Lys Glu Tyr Phe Lys Lys Leu Val
50 55 60 Asp Ile Gly Phe Lys Glu Ile Glu Val Ala Phe Pro Ser Ala
Ser Gln 65 70 75 80 Ile Asp Phe Asp Phe Thr Arg Phe Ala Val Glu Thr
Ala Pro Glu Asp 85 90 95 Val Ser Ile Gln Val Leu Ser Pro Cys Arg
Pro Glu Leu Ile Gly Arg 100 105 110 Thr Val Glu Ser Leu Lys Gly Ala
Lys Arg Ala Thr Val His Ile Tyr 115 120 125 Leu Ala Thr Ser Asp Cys
Phe Arg Asn Val Val Phe Gly Leu Ser Lys 130 135 140 Glu Glu Ser Lys
Ala Leu Ala Val Lys Cys Thr Lys Leu Val Arg Gln 145 150 155 160 Leu
Thr Lys Asp Asp Pro Ser Thr Ala Gly Thr Asp Trp Asp Phe Glu 165 170
175 Phe Ser Pro Glu Thr Phe Ser Asp Thr Asp Leu Asp Tyr Ala Val Glu
180 185 190 Val Cys Glu Ala Val Lys Glu Ala Trp Gly Pro Thr Glu Asp
Lys Pro 195 200 205 Ile Ile Phe Asn Leu Pro Ala Thr Val Glu Met Ala
Thr Pro Asn Ile 210 215 220 Tyr Ala Asp Gln Ile Glu Tyr Phe Ala Thr
His Ile Thr Asp Arg Glu 225 230 235 240 Thr Val Cys Ile Ser Leu His
Pro His Asn Asp Arg Gly Cys Ser Val 245 250 255 Ala Ala Ala Glu Leu
Gly Gln Leu Ala Gly Ala Asp Arg Val Glu Gly 260 265 270 Cys Leu Phe
Gly Asn Gly Glu Arg Thr Gly Asn Val Asp Leu Val Thr 275 280 285 Leu
Ala Leu Asn Leu Tyr Thr Gln Gly Val Ser Pro Lys Leu Asp Phe 290 295
300 Ser Asp Leu Asn Ser Val Ile Asp Ile Val Glu Lys Cys Asn Lys Ile
305 310 315 320 Pro Val His Ala Arg Ala Pro Tyr Gly Gly Ser Leu Val
Val Cys Ala 325 330 335 Phe Ser Gly Ser His Gln Asp Ala Ile Lys Lys
Gly Phe Ser Ala His 340 345 350 Glu Lys Lys Lys Glu Lys Ala Gly Gly
Lys Glu Val His Trp Gln Leu 355 360 365 Pro Tyr Leu Pro Leu Asp Pro
Glu Asp Ile Gly Arg Thr Tyr Glu Ala 370 375 380 Ile Ile Arg Val Asn
Ser Gln Ser Gly Lys Gly Gly Ser Ala Trp Val 385 390 395 400 Ile Leu
Arg Asn Leu Glu Leu Asp Leu Pro Arg Gly Leu Gln Ile Ala 405 410 415
Phe Ser Lys Val Val Gln Ala Arg Ala Glu Val Lys Gly Gln Glu Leu 420
425 430 Thr Asn Glu Glu Leu Cys Glu Leu Phe Lys Gln Glu Tyr Phe Ile
Asp 435 440 445 Tyr Asp Asp Glu Ala Pro Glu Gln Tyr Phe Lys Leu Val
Asp Tyr Ser 450 455 460 Ile Ser Thr Pro Ser Lys Gly Ile Lys Glu Ile
Gln Ala Asp Ile Glu 465 470 475 480 Val Asp Gly Lys Val Ile Ser Ile
Lys Gly Glu Gly Asn Gly Gln Leu 485 490 495 Ser Ala Phe Asn Asn Ala
Ile Ala Lys Tyr Leu Asn Ile Asp Ile Asp 500 505 510 Val Lys His Tyr
His Glu His Ser Leu Gly Glu Asp Ser Lys Ala Arg 515 520 525 Ala Ala
Thr Tyr Ile Glu Val Leu Val Asp Lys Lys Val Ala Arg Trp 530 535 540
Gly Val Gly Ile His Thr Asp Val Ser Gln Ala Ser Phe Leu Ser Leu 545
550 555 560 Ile Ser Ile Leu Asn Gly Leu His Lys Asn Lys Asn Ile 565
570 371254DNACandida albicans 37atgtctgttg cttctaatcc atatggtcca
aatccatctg atttcttatc taatgtgaat 60aaatttgaag tcattgaatc aactttaaga
gaaggtgaac aatttgccaa tgcctttttc 120accactgaaa aaaaaattga
aattgctaaa gctttagatg attttggggt tgattatatt 180gaattgactt
caccagtggc atctgaacaa tcaagaagag attgtgaagc catttgtaaa
240ttgggtttaa aagccaaaat attgacacat attagatgtc atatggatga
tgcccgtgtt 300gccgttgaaa ctggggttga tggggttgat gtggttattg
gaacttcaca atttttaaga 360caatattctc atggtaaaga tatgaattat
attgctcaaa gtgctattga agtcattgaa 420tttgttaaat ctaaaggtat
tgaaattcgt tttagttctg aagattcttt tagatcagat 480attgttgatt
tattaaacat ttatcgtact gttgataaaa tcggagtgaa tagagttggt
540attgccgata ctgttggttg tgctaaccca agacaagttt atgaattggt
taaaactttg 600aaatcggtgg tttcttgtga tattgaatgt catttccata
acgatactgg ttgtgccatt 660gctaatgctt atactgcctt ggaagccggt
gctaaattga ttgatgtttc tgtgttgggt 720attggtgaaa ggaatggtat
tactccattg ggggcattaa tggcaagaat gattactgct 780gatcgtgatt
atgtgttatc taaatataaa ttacacaaat tgagagattt agaaaatttg
840gttgctgatg ccgtacaaat taatattcca ttcaataatc caattactgg
attctgtgct 900tttactcata aagctggtat tcatgctaaa gccatcttgg
ccaatccatc aacatatgaa 960atcttgaatc caaatgattt cggtttaacc
agatatattc actttgctaa tagattgact 1020ggttggaatg ccattaaatc
aagagttgat caattgaatt tacatttgac tgatgatcaa 1080gttaaagaag
ttacaaataa aattaaaaaa ttgggtgatg ttagacaatt gaacattgat
1140gatgtcgatt caattattaa agatttccat gctgaacaaa gcactaccaa
tactcctctt 1200ttaaaaccag tagaggatga tgaaggtcca gaaattaaaa
aacaaaaagt atag 125438417PRTCandida albicans 38Met Ser Val Ala Ser
Asn Pro Tyr Gly Pro Asn Pro Ser Asp Phe Leu 1 5 10 15 Ser Asn Val
Asn Lys Phe Glu Val Ile Glu Ser Thr Leu Arg Glu Gly 20 25 30 Glu
Gln Phe Ala Asn Ala Phe Phe Thr Thr Glu Lys Lys Ile Glu Ile 35 40
45 Ala Lys Ala Leu Asp Asp Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser
50 55 60 Pro Val Ala Ser Glu Gln Ser Arg Arg Asp Cys Glu Ala Ile
Cys Lys 65 70 75 80 Leu Gly Leu Lys Ala Lys Ile Leu Thr His Ile Arg
Cys His Met Asp 85 90 95 Asp Ala Arg Val Ala Val Glu Thr Gly Val
Asp Gly Val Asp Val Val 100 105 110 Ile Gly Thr Ser Gln Phe Leu Arg
Gln Tyr Ser His Gly Lys Asp Met 115 120 125 Asn Tyr Ile Ala Gln Ser
Ala Ile Glu Val Ile Glu Phe Val Lys Ser 130 135 140 Lys Gly Ile Glu
Ile Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp 145 150 155 160 Ile
Val Asp Leu Leu Asn Ile Tyr Arg Thr Val Asp Lys Ile Gly Val 165 170
175 Asn Arg Val Gly Ile Ala Asp Thr Val Gly Cys Ala Asn Pro Arg Gln
180 185 190 Val Tyr Glu Leu Val Lys Thr Leu Lys Ser Val Val Ser Cys
Asp Ile 195 200 205 Glu Cys His Phe His Asn Asp Thr Gly Cys Ala Ile
Ala Asn Ala Tyr 210 215 220
Thr Ala Leu Glu Ala Gly Ala Lys Leu Ile Asp Val Ser Val Leu Gly 225
230 235 240 Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Ala Leu Met
Ala Arg 245 250 255 Met Ile Thr Ala Asp Arg Asp Tyr Val Leu Ser Lys
Tyr Lys Leu His 260 265 270 Lys Leu Arg Asp Leu Glu Asn Leu Val Ala
Asp Ala Val Gln Ile Asn 275 280 285 Ile Pro Phe Asn Asn Pro Ile Thr
Gly Phe Cys Ala Phe Thr His Lys 290 295 300 Ala Gly Ile His Ala Lys
Ala Ile Leu Ala Asn Pro Ser Thr Tyr Glu 305 310 315 320 Ile Leu Asn
Pro Asn Asp Phe Gly Leu Thr Arg Tyr Ile His Phe Ala 325 330 335 Asn
Arg Leu Thr Gly Trp Asn Ala Ile Lys Ser Arg Val Asp Gln Leu 340 345
350 Asn Leu His Leu Thr Asp Asp Gln Val Lys Glu Val Thr Asn Lys Ile
355 360 365 Lys Lys Leu Gly Asp Val Arg Gln Leu Asn Ile Asp Asp Val
Asp Ser 370 375 380 Ile Ile Lys Asp Phe His Ala Glu Gln Ser Thr Thr
Asn Thr Pro Leu 385 390 395 400 Leu Lys Pro Val Glu Asp Asp Glu Gly
Pro Glu Ile Lys Lys Gln Lys 405 410 415 Val 391287DNACandida
albicans 39atggttgacg gatataaaga agtatcagaa tcatttgatc gttccaaaat
ccaacataac 60ccttatggtc ctaatccagg tgattttctt tcgaatgttg gcaattttca
attgattgaa 120tcaactttga gagaaggtga acagtttgcc aatgcatttt
tcagcaccga aaccaaaatt 180gaaattgcta aagccttaga tgattttggg
gttgattata ttgaattgac ttcaccagtg 240gcatctgaac aatcaagaaa
agattgtgaa gccatttgta aattaggttt aaaagccaaa 300atattgactc
acattagatg tcatatggat gatgccagag ttgctgttga aactggggtc
360gatggagttg atgtggttat tggaacttcc caatttttaa gacaatactc
tcatggtaag 420gatatgaatt atattgcaca aagtgctatt gaagtcattg
aatttgtcaa atctaaaggt 480attgaaatcc gtttcagttc tgaagattct
tttagatcag atttggttga tttattaaac 540atttaccgta ctgttgataa
aattggggtt aacagagttg gtattgctga tactgttggt 600tgtgctaatc
caagacaagt ttatgaattg gtgagaacat tgaaatcagt agtcaagtgt
660gacattgaat gtcatttcca taatgatact ggctgtgcca ttgccaatgc
atacacagct 720ttggaaggtg gggccagatt gattgatgtt tccgtattgg
gtattggtga aagaaatggt 780attactccat tgggtgggtt aatggcgaga
atgattgctg ctgatcgtga atatgttttg 840tcaaaatata aagttcataa
attgagagat attgaaaatt tggttgctga ggcggttcaa 900gttaacattc
cattcaataa tccgatcact gggttctgtg ctttcactca taaagctggt
960atccatgcta aagctatctt ggccaatcca tctacttatg aaattttgag
tccaagtgat 1020ttcggtttaa ccagatatat tcactttgct aatagattga
ctggttggaa tgccatcaaa 1080tcaagagttg atcagttgaa cttgcattta
actgatgaac agtgtaaaga agtcactaac 1140aagattaaga aattgggtga
tgtcagacaa ttgaatatcg atgatgtgga ttcaatcatc 1200aaagatttcc
atgctgatat gtcaacacca cttttgaaat caaatggagc ggaagaagaa
1260ccagatgtaa aaaaacaaaa agtttaa 128740428PRTCandida albicans
40Met Val Asp Gly Tyr Lys Glu Val Ser Glu Ser Phe Asp Arg Ser Lys 1
5 10 15 Ile Gln His Asn Pro Tyr Gly Pro Asn Pro Gly Asp Phe Leu Ser
Asn 20 25 30 Val Gly Asn Phe Gln Leu Ile Glu Ser Thr Leu Arg Glu
Gly Glu Gln 35 40 45 Phe Ala Asn Ala Phe Phe Ser Thr Glu Thr Lys
Ile Glu Ile Ala Lys 50 55 60 Ala Leu Asp Asp Phe Gly Val Asp Tyr
Ile Glu Leu Thr Ser Pro Val 65 70 75 80 Ala Ser Glu Gln Ser Arg Lys
Asp Cys Glu Ala Ile Cys Lys Leu Gly 85 90 95 Leu Lys Ala Lys Ile
Leu Thr His Ile Arg Cys His Met Asp Asp Ala 100 105 110 Arg Val Ala
Val Glu Thr Gly Val Asp Gly Val Asp Val Val Ile Gly 115 120 125 Thr
Ser Gln Phe Leu Arg Gln Tyr Ser His Gly Lys Asp Met Asn Tyr 130 135
140 Ile Ala Gln Ser Ala Ile Glu Val Ile Glu Phe Val Lys Ser Lys Gly
145 150 155 160 Ile Glu Ile Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser
Asp Leu Val 165 170 175 Asp Leu Leu Asn Ile Tyr Arg Thr Val Asp Lys
Ile Gly Val Asn Arg 180 185 190 Val Gly Ile Ala Asp Thr Val Gly Cys
Ala Asn Pro Arg Gln Val Tyr 195 200 205 Glu Leu Val Arg Thr Leu Lys
Ser Val Val Lys Cys Asp Ile Glu Cys 210 215 220 His Phe His Asn Asp
Thr Gly Cys Ala Ile Ala Asn Ala Tyr Thr Ala 225 230 235 240 Leu Glu
Gly Gly Ala Arg Leu Ile Asp Val Ser Val Leu Gly Ile Gly 245 250 255
Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu Met Ala Arg Met Ile 260
265 270 Ala Ala Asp Arg Glu Tyr Val Leu Ser Lys Tyr Lys Val His Lys
Leu 275 280 285 Arg Asp Ile Glu Asn Leu Val Ala Glu Ala Val Gln Val
Asn Ile Pro 290 295 300 Phe Asn Asn Pro Ile Thr Gly Phe Cys Ala Phe
Thr His Lys Ala Gly 305 310 315 320 Ile His Ala Lys Ala Ile Leu Ala
Asn Pro Ser Thr Tyr Glu Ile Leu 325 330 335 Ser Pro Ser Asp Phe Gly
Leu Thr Arg Tyr Ile His Phe Ala Asn Arg 340 345 350 Leu Thr Gly Trp
Asn Ala Ile Lys Ser Arg Val Asp Gln Leu Asn Leu 355 360 365 His Leu
Thr Asp Glu Gln Cys Lys Glu Val Thr Asn Lys Ile Lys Lys 370 375 380
Leu Gly Asp Val Arg Gln Leu Asn Ile Asp Asp Val Asp Ser Ile Ile 385
390 395 400 Lys Asp Phe His Ala Asp Met Ser Thr Pro Leu Leu Lys Ser
Asn Gly 405 410 415 Ala Glu Glu Glu Pro Asp Val Lys Lys Gln Lys Val
420 425 41 1827DNACandida glabrata 41atgagagcta ccgttatcag
actctcgagg gctgcgaagt caattccgcc cgtgaaattg 60gcgtataaga acatgttgaa
agacccttcc atcaaataca aaccattctc cattgctcca 120aagcttactg
acaggaaatg gccagacaat accattacca aggcaccaag gtggttgtct
180acagacttga gagacggtaa ccagtctctc ccggacccga tgtccattga
gcagaagaaa 240gagtacttcc acaagctggt ggagattggc ttcaaagaga
tagaagtcag ttttccatct 300gcctcgcaga ccgacttcga tttcacaagg
tacgctgtgg agaatgctcc agatgatgtt 360accatacagt gtcttgtgca
atccagagaa cacttgatca gaagaactgt ggagtcgttg 420actggtgcca
agcgtgccac tatacatact tacttggcca ccagcgacat gttcagagag
480atagtcttca acatgtctaa ggaagacgct atcgccaaag ccgtcgaagc
cactaaactg 540gtcagaagct tgaccaagga cgacccttct cagcaggcta
cccgttggtc ctatgagttc 600tctccagaat gtttcagtga taccccagtc
gaatttgccg ttgaaatctg tgaagcagta 660aaagctgcct gggaaccaac
cgaggacaac cctatcatat ttaacctacc tgccacagtc 720gaggtcgcct
ctccaaacat ctacgctgac caaatcgaat atttctgcac acacatcacc
780gaaagagaga aggtgtgtgt ctctacgcat acccacaacg accgtggctg
cggtgttgcc 840gctaccgaac ttggtataat ggcaggcgct gatcgtgttg
aaggttgtgt cttcggaaat 900ggtgaacgta ctggtaacgt tgacttggta
accgtggcat tgaacatgta cacgcaaggt 960gtctctccta acttggactt
ctccgacata aggtctgtaa tcgaggttgt tgaacgttgt 1020aacaaattgc
ctgtcccagc cagagcacca tacggtggtg acttggtcgt atgtgcattc
1080tctggttctc accaggacgc catcaagaag ggtttctcgg ttcaacaaaa
gaagcgtgac 1140caaggcgaca ttcaatggag aatcccatat ttgccattgg
atccaaagga tatcggccgt 1200gactacgaag ctgtcatcag agtcaactct
caatctggta agggtggtgc tgcttgggtt 1260gtcctaagag ccttgggcct
agacatgcca agaaccatgc aaattgagtt ctccaccagt 1320gtacaagaac
acgctgactc tctaggtaga gaactaaagg ccgaagagat tgtcaacttg
1380tttaaggaat cttacaacta caacaacgaa atcttccaac atatctcttt
ggttgattac 1440aacgttgaga aattcggtgc tgagcgcaga attctaaatg
gtcaagttga aatcaatggt 1500gaagttgtcg acatcaaggg taccggtaac
ggtccaatct cttctttggt cgatgctttg 1560tccaacttat tgaacatcaa
acttggtgtc agcaactata gtgaacactc tttgggttca 1620ggttcatcca
ctcaagccgc ttctttcatc aacttaactt acagacgtga tgaagataat
1680gaaaaggctt accaatgggg tgtaggtgtg tctgaggatg ttggtgatgc
ttctgtcaag 1740gcaatctttg ccactttgaa ttctgtaatt caaaaaggtg
acattagtat cccaaagtct 1800aagaaggctg cctctggttc tgcttaa
182742608PRTCandida glabrata 42Met Arg Ala Thr Val Ile Arg Leu Ser
Arg Ala Ala Lys Ser Ile Pro 1 5 10 15 Pro Val Lys Leu Ala Tyr Lys
Asn Met Leu Lys Asp Pro Ser Ile Lys 20 25 30 Tyr Lys Pro Phe Ser
Ile Ala Pro Lys Leu Thr Asp Arg Lys Trp Pro 35 40 45 Asp Asn Thr
Ile Thr Lys Ala Pro Arg Trp Leu Ser Thr Asp Leu Arg 50 55 60 Asp
Gly Asn Gln Ser Leu Pro Asp Pro Met Ser Ile Glu Gln Lys Lys 65 70
75 80 Glu Tyr Phe His Lys Leu Val Glu Ile Gly Phe Lys Glu Ile Glu
Val 85 90 95 Ser Phe Pro Ser Ala Ser Gln Thr Asp Phe Asp Phe Thr
Arg Tyr Ala 100 105 110 Val Glu Asn Ala Pro Asp Asp Val Thr Ile Gln
Cys Leu Val Gln Ser 115 120 125 Arg Glu His Leu Ile Arg Arg Thr Val
Glu Ser Leu Thr Gly Ala Lys 130 135 140 Arg Ala Thr Ile His Thr Tyr
Leu Ala Thr Ser Asp Met Phe Arg Glu 145 150 155 160 Ile Val Phe Asn
Met Ser Lys Glu Asp Ala Ile Ala Lys Ala Val Glu 165 170 175 Ala Thr
Lys Leu Val Arg Ser Leu Thr Lys Asp Asp Pro Ser Gln Gln 180 185 190
Ala Thr Arg Trp Ser Tyr Glu Phe Ser Pro Glu Cys Phe Ser Asp Thr 195
200 205 Pro Val Glu Phe Ala Val Glu Ile Cys Glu Ala Val Lys Ala Ala
Trp 210 215 220 Glu Pro Thr Glu Asp Asn Pro Ile Ile Phe Asn Leu Pro
Ala Thr Val 225 230 235 240 Glu Val Ala Ser Pro Asn Ile Tyr Ala Asp
Gln Ile Glu Tyr Phe Cys 245 250 255 Thr His Ile Thr Glu Arg Glu Lys
Val Cys Val Ser Thr His Thr His 260 265 270 Asn Asp Arg Gly Cys Gly
Val Ala Ala Thr Glu Leu Gly Ile Met Ala 275 280 285 Gly Ala Asp Arg
Val Glu Gly Cys Val Phe Gly Asn Gly Glu Arg Thr 290 295 300 Gly Asn
Val Asp Leu Val Thr Val Ala Leu Asn Met Tyr Thr Gln Gly 305 310 315
320 Val Ser Pro Asn Leu Asp Phe Ser Asp Ile Arg Ser Val Ile Glu Val
325 330 335 Val Glu Arg Cys Asn Lys Leu Pro Val Pro Ala Arg Ala Pro
Tyr Gly 340 345 350 Gly Asp Leu Val Val Cys Ala Phe Ser Gly Ser His
Gln Asp Ala Ile 355 360 365 Lys Lys Gly Phe Ser Val Gln Gln Lys Lys
Arg Asp Gln Gly Asp Ile 370 375 380 Gln Trp Arg Ile Pro Tyr Leu Pro
Leu Asp Pro Lys Asp Ile Gly Arg 385 390 395 400 Asp Tyr Glu Ala Val
Ile Arg Val Asn Ser Gln Ser Gly Lys Gly Gly 405 410 415 Ala Ala Trp
Val Val Leu Arg Ala Leu Gly Leu Asp Met Pro Arg Thr 420 425 430 Met
Gln Ile Glu Phe Ser Thr Ser Val Gln Glu His Ala Asp Ser Leu 435 440
445 Gly Arg Glu Leu Lys Ala Glu Glu Ile Val Asn Leu Phe Lys Glu Ser
450 455 460 Tyr Asn Tyr Asn Asn Glu Ile Phe Gln His Ile Ser Leu Val
Asp Tyr 465 470 475 480 Asn Val Glu Lys Phe Gly Ala Glu Arg Arg Ile
Leu Asn Gly Gln Val 485 490 495 Glu Ile Asn Gly Glu Val Val Asp Ile
Lys Gly Thr Gly Asn Gly Pro 500 505 510 Ile Ser Ser Leu Val Asp Ala
Leu Ser Asn Leu Leu Asn Ile Lys Leu 515 520 525 Gly Val Ser Asn Tyr
Ser Glu His Ser Leu Gly Ser Gly Ser Ser Thr 530 535 540 Gln Ala Ala
Ser Phe Ile Asn Leu Thr Tyr Arg Arg Asp Glu Asp Asn 545 550 555 560
Glu Lys Ala Tyr Gln Trp Gly Val Gly Val Ser Glu Asp Val Gly Asp 565
570 575 Ala Ser Val Lys Ala Ile Phe Ala Thr Leu Asn Ser Val Ile Gln
Lys 580 585 590 Gly Asp Ile Ser Ile Pro Lys Ser Lys Lys Ala Ala Ser
Gly Ser Ala 595 600 605 43 1818DNACandida glabrata 43atgagacaaa
caattccaaa ttttgcagag catgtctctc gtgcagccaa gacaattgct 60ccagtcaaat
tgggtttcaa gaatatgctt gctaatccaa gtgtcaaata tagaccattt
120caaggcccaa aattgacaaa tagacaatgg cctaacaaga caattaagag
agctccaaga 180tggctttcta ccgatttgag agatggtaac caatctctcc
cggaccctat gtcagtagag 240caaaagaaag aatactttca caaacttgtt
gaaatcgggt ttaaagagat agaagtcagt 300tttccgtcag catcgcaaac
cgatttcgat ttcacaagat acgctgtaga aaacgcacca 360gacgatgttt
ctatccagtg tcttgtccaa tctagggagc atctgatcaa gaggacagtt
420gaagcattga ccggtgctaa gcgtgctacc atacatacat acttggccac
aagtgatatg 480ttccgtgaga ttgttttcaa tatgtctcaa gaagaagcca
ttgccaaagc tgtagaagca 540accaagctag tacggaaatt gaccaaggat
gatccatctc aaaaagcaac taggtggtct 600tacgaatttt ctccagaatg
ttttagtgat acaccagtag aatttgccgt tgaaatctgt 660gaggctgtga
aagctgcatg ggaaccaacg gttgataatc ctattatctt taacttacct
720gcaaccgttg aagtagcaac tccaaatgta tacgctgatc agatcgaata
cttctctact 780catattagcg aacgtgaaaa ggtttgtatc tccacccatg
ctcacaatga ccgtggctgt 840ggcgttgctg ctacagagtt gggtatcttg
gctggtgctg atcgagttga aggctgtata 900ttcgggaatg gtgaacgtac
aggtaatgtc gacctggtaa ccgtcgcctt aaacatgtat 960acccagggtg
tttctcccgg tcttgacttt tcagacatga gaagtgttat cgagatcgtt
1020gaacgttgta acaagattcc agtaccagct agagctccat atggtggtga
ccttgttgtt 1080tgcgcctttt caggctctca ccaagatgct attaaaaaag
gatttgcttt acaacaaaag 1140aagcgtgctc aaggtgaaac tttatggagg
attccatatt tgccattaga tccaaaggac 1200atcggccgtg actatgaagc
ggttatcagg gtcaactcac aatctggtaa gggtggtgct 1260gcttgggtta
ttttaaggtc tttgggtcta gacaccccaa gaaacatgca aatgcaattc
1320tctaccattg tgcaaaatga agctgacaca agaggcaagg aattatctgc
agaggagatt 1380actgcattat tcaagtctac ctataattac aacaacgaaa
cccatcaata cgtatctttg 1440ctcgactatg atgtgaagaa gattgacaac
gaccgtagaa tcctaacagg gcaagttgaa 1500attaacgaca agatcattcc
aattaagggt attggtaacg gtcctatttc ttctttagta 1560gatgccctat
caaacttatt caacgtcaaa tttggtgttg aaaactatac agaacatgct
1620ttaggttccg gttccaaaac ccaagccgcc tctttcattc acatctctta
cagagatgct 1680gctaccaatg aaaaggagta cagttggggt gtcggtgtct
ctgaagatgt tggtgaagca 1740tctgttaggg ccattttctc aaccattaac
agcattatcc attcaggtga agtcactctt 1800cctactgaaa acaattag
181844605PRTCandida glabrata 44Met Arg Gln Thr Ile Pro Asn Phe Ala
Glu His Val Ser Arg Ala Ala 1 5 10 15 Lys Thr Ile Ala Pro Val Lys
Leu Gly Phe Lys Asn Met Leu Ala Asn 20 25 30 Pro Ser Val Lys Tyr
Arg Pro Phe Gln Gly Pro Lys Leu Thr Asn Arg 35 40 45 Gln Trp Pro
Asn Lys Thr Ile Lys Arg Ala Pro Arg Trp Leu Ser Thr 50 55 60 Asp
Leu Arg Asp Gly Asn Gln Ser Leu Pro Asp Pro Met Ser Val Glu 65 70
75 80 Gln Lys Lys Glu Tyr Phe His Lys Leu Val Glu Ile Gly Phe Lys
Glu 85 90 95 Ile Glu Val Ser Phe Pro Ser Ala Ser Gln Thr Asp Phe
Asp Phe Thr 100 105 110 Arg Tyr Ala Val Glu Asn Ala Pro Asp Asp Val
Ser Ile Gln Cys Leu 115 120 125 Val Gln Ser Arg Glu His Leu Ile Lys
Arg Thr Val Glu Ala Leu Thr 130 135 140 Gly Ala Lys Arg Ala Thr Ile
His Thr Tyr Leu Ala Thr Ser Asp Met 145 150 155 160 Phe Arg Glu Ile
Val Phe Asn Met Ser Gln Glu Glu Ala Ile Ala Lys 165 170 175 Ala Val
Glu Ala Thr Lys Leu Val Arg Lys Leu Thr Lys Asp Asp Pro 180 185 190
Ser Gln Lys Ala Thr Arg Trp Ser Tyr Glu Phe Ser Pro Glu Cys Phe 195
200 205 Ser Asp Thr Pro Val Glu Phe Ala Val Glu Ile Cys Glu Ala Val
Lys 210 215 220 Ala Ala Trp Glu Pro Thr Val Asp Asn Pro Ile Ile Phe
Asn Leu Pro 225 230 235 240 Ala Thr Val Glu Val Ala Thr Pro Asn Val
Tyr Ala Asp Gln Ile Glu 245 250 255 Tyr Phe Ser Thr His Ile Ser Glu
Arg Glu Lys Val Cys Ile Ser Thr 260 265 270 His Ala His Asn Asp Arg
Gly Cys Gly Val Ala Ala Thr Glu Leu
Gly 275 280 285 Ile Leu Ala Gly Ala Asp Arg Val Glu Gly Cys Ile Phe
Gly Asn Gly 290 295 300 Glu Arg Thr Gly Asn Val Asp Leu Val Thr Val
Ala Leu Asn Met Tyr 305 310 315 320 Thr Gln Gly Val Ser Pro Gly Leu
Asp Phe Ser Asp Met Arg Ser Val 325 330 335 Ile Glu Ile Val Glu Arg
Cys Asn Lys Ile Pro Val Pro Ala Arg Ala 340 345 350 Pro Tyr Gly Gly
Asp Leu Val Val Cys Ala Phe Ser Gly Ser His Gln 355 360 365 Asp Ala
Ile Lys Lys Gly Phe Ala Leu Gln Gln Lys Lys Arg Ala Gln 370 375 380
Gly Glu Thr Leu Trp Arg Ile Pro Tyr Leu Pro Leu Asp Pro Lys Asp 385
390 395 400 Ile Gly Arg Asp Tyr Glu Ala Val Ile Arg Val Asn Ser Gln
Ser Gly 405 410 415 Lys Gly Gly Ala Ala Trp Val Ile Leu Arg Ser Leu
Gly Leu Asp Thr 420 425 430 Pro Arg Asn Met Gln Met Gln Phe Ser Thr
Ile Val Gln Asn Glu Ala 435 440 445 Asp Thr Arg Gly Lys Glu Leu Ser
Ala Glu Glu Ile Thr Ala Leu Phe 450 455 460 Lys Ser Thr Tyr Asn Tyr
Asn Asn Glu Thr His Gln Tyr Val Ser Leu 465 470 475 480 Leu Asp Tyr
Asp Val Lys Lys Ile Asp Asn Asp Arg Arg Ile Leu Thr 485 490 495 Gly
Gln Val Glu Ile Asn Asp Lys Ile Ile Pro Ile Lys Gly Ile Gly 500 505
510 Asn Gly Pro Ile Ser Ser Leu Val Asp Ala Leu Ser Asn Leu Phe Asn
515 520 525 Val Lys Phe Gly Val Glu Asn Tyr Thr Glu His Ala Leu Gly
Ser Gly 530 535 540 Ser Lys Thr Gln Ala Ala Ser Phe Ile His Ile Ser
Tyr Arg Asp Ala 545 550 555 560 Ala Thr Asn Glu Lys Glu Tyr Ser Trp
Gly Val Gly Val Ser Glu Asp 565 570 575 Val Gly Glu Ala Ser Val Arg
Ala Ile Phe Ser Thr Ile Asn Ser Ile 580 585 590 Ile His Ser Gly Glu
Val Thr Leu Pro Thr Glu Asn Asn 595 600 605 45 1752DNAKluyveromyces
lactis 45atgccattct acaaagatcc ttcagtgaag tataaaccat tcgttagcaa
cgtcaaatta 60caggacagga aatggcctag taaaaccctt aataaggctc caagatggtt
agctaccgat 120ttaagagatg ggaatcagtc tttacctgac ccgatgaatt
tggaagagaa gaaactgatg 180ctcgataagt tatgcgaatt gggtttcaaa
gagattgaag ttgctttccc tagtgcttct 240aatatcgatt tccaattcac
tcaatatgca gtgaaaaacg taccagaaga cgtttccatt 300caagttcttt
ctccatgtcg tgaacccttg atcgaacgta ccgttgaatc tttggtcggt
360gccaagagag ccattgtaca tatctatctc gcgacatcac catgtttcag
agaaatcgtt 420ttcaacaata tgtctcatga agaaagtatt gaaaaggctg
tgaaatgtgc caaacttgtt 480aggtccttga caaaagacca tccggataga
caagataccc attggtcatt tgagttttct 540ccagaaacgt tcagcgatag
tgaaccggat ttcgttctag agatttgtga agctgttaag 600gctgcttggg
gacccactga agataatcca atcattttca atttgccagc taccgtcgag
660atggctacac caaacgtgta cgctgaccaa atcgaatatt tcgctcaaag
tatctccgaa 720cgtgagaaag tatgtatctc tctccatcca cataacgatc
gtgggtgtgc tgtggcagct 780gcagaattag ctcaaatggc tggtgcagat
cgtgtcgagg gatgtctctt cggtaacggt 840gaacgtaccg gtaacgttga
tttggttacc ttggcattaa acctctacac acagggtgta 900tctccaaacc
tcgatttctc cgatatggct tctattattg aagtcgttga gaaatgtaat
960aagattcccg tgcatgctag agcaccctac ggaggacaac ttgtcgtttg
tgcattcagt 1020ggttctcatc aagatgccat caaaaagggt ttcgaaaaat
acgacaacaa ggttaaggct 1080ttacaagaaa aagagggtcc agatgcagtg
gtaccttgga aaatgccata tctccccttg 1140gatcctcagg atattggaag
aacgtatgag gctatcatca gagtcaactc gcaatcaggt 1200aaaggtggtt
cttcttgggt tatcctaaag aacttggagc tagatttacc aagagatcta
1260caaattgcat actctaagat cgttcaaaat gaaactgaga tagtcggtag
agagttgaag 1320agcgatgaac taatctcttt attcgagaaa tcgtatttcg
ttggatctca ttcaactact 1380ggtaaattca agtttatcga ctataaatat
gacaaatctc cggagaattt cactctttcg 1440gtgcagctat cagatggaac
tactcaatgg gatttggaag gtactggtaa cggtccaatc 1500tcttctttca
tcgatgctgt gaataaaaac ttcaaaacta atcttgatgt gaaaaactat
1560catgagcatt ccttgggtaa gagttccgat tcgagagctg ctacttatat
ctctgtctct 1620catgaaggat ttgttcaatg gggtgttggt attcatgagg
atactactct ggcttcattc 1680ttggcgttgt tatcttgtat aaacggtctt
gatagggcaa agaacttcac tgtcaattca 1740gctgccaatt ga
175246583PRTKluyveromyces lactis 46Met Pro Phe Tyr Lys Asp Pro Ser
Val Lys Tyr Lys Pro Phe Val Ser 1 5 10 15 Asn Val Lys Leu Gln Asp
Arg Lys Trp Pro Ser Lys Thr Leu Asn Lys 20 25 30 Ala Pro Arg Trp
Leu Ala Thr Asp Leu Arg Asp Gly Asn Gln Ser Leu 35 40 45 Pro Asp
Pro Met Asn Leu Glu Glu Lys Lys Leu Met Leu Asp Lys Leu 50 55 60
Cys Glu Leu Gly Phe Lys Glu Ile Glu Val Ala Phe Pro Ser Ala Ser 65
70 75 80 Asn Ile Asp Phe Gln Phe Thr Gln Tyr Ala Val Lys Asn Val
Pro Glu 85 90 95 Asp Val Ser Ile Gln Val Leu Ser Pro Cys Arg Glu
Pro Leu Ile Glu 100 105 110 Arg Thr Val Glu Ser Leu Val Gly Ala Lys
Arg Ala Ile Val His Ile 115 120 125 Tyr Leu Ala Thr Ser Pro Cys Phe
Arg Glu Ile Val Phe Asn Asn Met 130 135 140 Ser His Glu Glu Ser Ile
Glu Lys Ala Val Lys Cys Ala Lys Leu Val 145 150 155 160 Arg Ser Leu
Thr Lys Asp His Pro Asp Arg Gln Asp Thr His Trp Ser 165 170 175 Phe
Glu Phe Ser Pro Glu Thr Phe Ser Asp Ser Glu Pro Asp Phe Val 180 185
190 Leu Glu Ile Cys Glu Ala Val Lys Ala Ala Trp Gly Pro Thr Glu Asp
195 200 205 Asn Pro Ile Ile Phe Asn Leu Pro Ala Thr Val Glu Met Ala
Thr Pro 210 215 220 Asn Val Tyr Ala Asp Gln Ile Glu Tyr Phe Ala Gln
Ser Ile Ser Glu 225 230 235 240 Arg Glu Lys Val Cys Ile Ser Leu His
Pro His Asn Asp Arg Gly Cys 245 250 255 Ala Val Ala Ala Ala Glu Leu
Ala Gln Met Ala Gly Ala Asp Arg Val 260 265 270 Glu Gly Cys Leu Phe
Gly Asn Gly Glu Arg Thr Gly Asn Val Asp Leu 275 280 285 Val Thr Leu
Ala Leu Asn Leu Tyr Thr Gln Gly Val Ser Pro Asn Leu 290 295 300 Asp
Phe Ser Asp Met Ala Ser Ile Ile Glu Val Val Glu Lys Cys Asn 305 310
315 320 Lys Ile Pro Val His Ala Arg Ala Pro Tyr Gly Gly Gln Leu Val
Val 325 330 335 Cys Ala Phe Ser Gly Ser His Gln Asp Ala Ile Lys Lys
Gly Phe Glu 340 345 350 Lys Tyr Asp Asn Lys Val Lys Ala Leu Gln Glu
Lys Glu Gly Pro Asp 355 360 365 Ala Val Val Pro Trp Lys Met Pro Tyr
Leu Pro Leu Asp Pro Gln Asp 370 375 380 Ile Gly Arg Thr Tyr Glu Ala
Ile Ile Arg Val Asn Ser Gln Ser Gly 385 390 395 400 Lys Gly Gly Ser
Ser Trp Val Ile Leu Lys Asn Leu Glu Leu Asp Leu 405 410 415 Pro Arg
Asp Leu Gln Ile Ala Tyr Ser Lys Ile Val Gln Asn Glu Thr 420 425 430
Glu Ile Val Gly Arg Glu Leu Lys Ser Asp Glu Leu Ile Ser Leu Phe 435
440 445 Glu Lys Ser Tyr Phe Val Gly Ser His Ser Thr Thr Gly Lys Phe
Lys 450 455 460 Phe Ile Asp Tyr Lys Tyr Asp Lys Ser Pro Glu Asn Phe
Thr Leu Ser 465 470 475 480 Val Gln Leu Ser Asp Gly Thr Thr Gln Trp
Asp Leu Glu Gly Thr Gly 485 490 495 Asn Gly Pro Ile Ser Ser Phe Ile
Asp Ala Val Asn Lys Asn Phe Lys 500 505 510 Thr Asn Leu Asp Val Lys
Asn Tyr His Glu His Ser Leu Gly Lys Ser 515 520 525 Ser Asp Ser Arg
Ala Ala Thr Tyr Ile Ser Val Ser His Glu Gly Phe 530 535 540 Val Gln
Trp Gly Val Gly Ile His Glu Asp Thr Thr Leu Ala Ser Phe 545 550 555
560 Leu Ala Leu Leu Ser Cys Ile Asn Gly Leu Asp Arg Ala Lys Asn Phe
565 570 575 Thr Val Asn Ser Ala Ala Asn 580 47 1830DNAKluyveromyces
lactis 47atgatattca ggaacaccgt tgtgcgttta gcacaggctg ggaaaaaagc
tattcctcca 60gtgaaactag cgtacaagaa tatgctaaaa gatccatcga cgaaatatag
accataccca 120cagatcaact tggaaaatag acaatggcct tcgaagacca
tcaccaaggc tcctaggtgg 180ctttctaccg atctaagaga cgggaatcaa
tctttaccag atcctatgtc tgtcgagcag 240aagaaggaat atttccataa
gttgattgag attggtttca aagaaattga ggtctcattc 300ccatctgcgt
cgcaaacaga tttcgacttc acaagatacg ctgttgaaaa cgccccagaa
360gatgtttcca ttcaatgtct tgttcaatcg agagaacatt tgattagaag
aacagttgaa 420gctttgcatg gtgctaagaa agccaccatc catacgtatt
tggccacctc cgacatgttc 480cgtgacattg tgttcaacat gtcccaagaa
gaagctattg ctaaagctgt ggaagccacc 540aagttagtta ggaaattgac
caaggatgat ccttcgcaaa gtgctacaca atggacttac 600cagttctctc
cagaatgttt cagtgataca cctgtagaat ttgctgttga gatctgtgaa
660gccgtaaagg ctgcttggga accaactgag gaaaacccaa tcattttcaa
cctacctgct 720accgtcgaag tcgctactcc aaacatttac gctgatcaaa
ttgaatactt ttcaactcac 780atatctgaac gtgaaaaggt ctgtatctcc
acacatgcgc acaacgaccg tggctgtggt 840gttgctgctt ctgaactagg
tattttggct ggtgctgacc gtgtcgaagg ttgtttattc 900ggtaatggtg
aacgtactgg taacgttgac ttggttactg tcgcattgaa catgtacact
960caaggtgttt ctccagaatt agacttatct gatattaact cagtcattga
agtagtggaa 1020agatgtaaca agattgcagt ttcaccaaga gccccatatg
gtggtgactt ggtcgtttgt 1080gctttcagtg gttctcatca agatgctatc
aaaaagggtt tcaatcttca agaaaagaga 1140cgtagtcaag gtgatactct
atggaaaatt ccatacttgc cattggatcc aaaggatatc 1200ggtagagact
acgaagctgt catccgtgtc aactctcaat ctggtaaggg gggtgccgct
1260tgggttgtct tgagatcttt gggcctagat ttgccaagaa acttgcaaat
tgaattttcc 1320actcaagtgc aagaaaaggc tgatgctcta ggtaaggaac
taaaggcaaa cgaaattgtc 1380agcaccttca agtcgttata caacctcgat
ggaagcgcct ccaacatttc tttgttagaa 1440tacaatgttt ctaaagtaca
gggtgatcag aagagttttg ttggtcaagt ccagatcgac 1500aacgaagtcg
tcggcattga aggtctcgga aacggtccaa tttcctctct aatcgatgcg
1560ttgtcaaatt tgctcggtgt taaacttggt gttgccaact acaccgaaca
ttccttagga 1620tctggttctt caacaaaggc tgcttcttac gtgcatattg
cttacagaag agaaattgac 1680aacgaaaagg cctaccaatg gggtattggt
atgtctgaag atgttggaga ggcttctgcc 1740aaagccatcc tttctgctgt
taataacttg atcaaaaagg gcgaactaac aataccagct 1800catcgtgact
cagcctcagc atctgcatag 183048609PRTKluyveromyces lactis 48Met Ile
Phe Arg Asn Thr Val Val Arg Leu Ala Gln Ala Gly Lys Lys 1 5 10 15
Ala Ile Pro Pro Val Lys Leu Ala Tyr Lys Asn Met Leu Lys Asp Pro 20
25 30 Ser Thr Lys Tyr Arg Pro Tyr Pro Gln Ile Asn Leu Glu Asn Arg
Gln 35 40 45 Trp Pro Ser Lys Thr Ile Thr Lys Ala Pro Arg Trp Leu
Ser Thr Asp 50 55 60 Leu Arg Asp Gly Asn Gln Ser Leu Pro Asp Pro
Met Ser Val Glu Gln 65 70 75 80 Lys Lys Glu Tyr Phe His Lys Leu Ile
Glu Ile Gly Phe Lys Glu Ile 85 90 95 Glu Val Ser Phe Pro Ser Ala
Ser Gln Thr Asp Phe Asp Phe Thr Arg 100 105 110 Tyr Ala Val Glu Asn
Ala Pro Glu Asp Val Ser Ile Gln Cys Leu Val 115 120 125 Gln Ser Arg
Glu His Leu Ile Arg Arg Thr Val Glu Ala Leu His Gly 130 135 140 Ala
Lys Lys Ala Thr Ile His Thr Tyr Leu Ala Thr Ser Asp Met Phe 145 150
155 160 Arg Asp Ile Val Phe Asn Met Ser Gln Glu Glu Ala Ile Ala Lys
Ala 165 170 175 Val Glu Ala Thr Lys Leu Val Arg Lys Leu Thr Lys Asp
Asp Pro Ser 180 185 190 Gln Ser Ala Thr Gln Trp Thr Tyr Gln Phe Ser
Pro Glu Cys Phe Ser 195 200 205 Asp Thr Pro Val Glu Phe Ala Val Glu
Ile Cys Glu Ala Val Lys Ala 210 215 220 Ala Trp Glu Pro Thr Glu Glu
Asn Pro Ile Ile Phe Asn Leu Pro Ala 225 230 235 240 Thr Val Glu Val
Ala Thr Pro Asn Ile Tyr Ala Asp Gln Ile Glu Tyr 245 250 255 Phe Ser
Thr His Ile Ser Glu Arg Glu Lys Val Cys Ile Ser Thr His 260 265 270
Ala His Asn Asp Arg Gly Cys Gly Val Ala Ala Ser Glu Leu Gly Ile 275
280 285 Leu Ala Gly Ala Asp Arg Val Glu Gly Cys Leu Phe Gly Asn Gly
Glu 290 295 300 Arg Thr Gly Asn Val Asp Leu Val Thr Val Ala Leu Asn
Met Tyr Thr 305 310 315 320 Gln Gly Val Ser Pro Glu Leu Asp Leu Ser
Asp Ile Asn Ser Val Ile 325 330 335 Glu Val Val Glu Arg Cys Asn Lys
Ile Ala Val Ser Pro Arg Ala Pro 340 345 350 Tyr Gly Gly Asp Leu Val
Val Cys Ala Phe Ser Gly Ser His Gln Asp 355 360 365 Ala Ile Lys Lys
Gly Phe Asn Leu Gln Glu Lys Arg Arg Ser Gln Gly 370 375 380 Asp Thr
Leu Trp Lys Ile Pro Tyr Leu Pro Leu Asp Pro Lys Asp Ile 385 390 395
400 Gly Arg Asp Tyr Glu Ala Val Ile Arg Val Asn Ser Gln Ser Gly Lys
405 410 415 Gly Gly Ala Ala Trp Val Val Leu Arg Ser Leu Gly Leu Asp
Leu Pro 420 425 430 Arg Asn Leu Gln Ile Glu Phe Ser Thr Gln Val Gln
Glu Lys Ala Asp 435 440 445 Ala Leu Gly Lys Glu Leu Lys Ala Asn Glu
Ile Val Ser Thr Phe Lys 450 455 460 Ser Leu Tyr Asn Leu Asp Gly Ser
Ala Ser Asn Ile Ser Leu Leu Glu 465 470 475 480 Tyr Asn Val Ser Lys
Val Gln Gly Asp Gln Lys Ser Phe Val Gly Gln 485 490 495 Val Gln Ile
Asp Asn Glu Val Val Gly Ile Glu Gly Leu Gly Asn Gly 500 505 510 Pro
Ile Ser Ser Leu Ile Asp Ala Leu Ser Asn Leu Leu Gly Val Lys 515 520
525 Leu Gly Val Ala Asn Tyr Thr Glu His Ser Leu Gly Ser Gly Ser Ser
530 535 540 Thr Lys Ala Ala Ser Tyr Val His Ile Ala Tyr Arg Arg Glu
Ile Asp 545 550 555 560 Asn Glu Lys Ala Tyr Gln Trp Gly Ile Gly Met
Ser Glu Asp Val Gly 565 570 575 Glu Ala Ser Ala Lys Ala Ile Leu Ser
Ala Val Asn Asn Leu Ile Lys 580 585 590 Lys Gly Glu Leu Thr Ile Pro
Ala His Arg Asp Ser Ala Ser Ala Ser 595 600 605 Ala
491341DNAYarrowia lipolytica 49atgtgcgcaa cagataacgc ccccgccgct
aacgctgctc ctgagaagcc ctccaacgtt 60ggagtcgagg tcggtcacac cggcgagcag
actaatcctt acggagccaa ccccgccgat 120ttcctttcta acgtgtccaa
gttccagctc atcgagtcca ctctgcgaga gggagagcag 180tttgcctctg
ccttctttga caccgagacc aagatcgaga ttgccaaggc tctggacgac
240tttggtgtcg actacatcga gctgacctcc cccgcagcat cggagcagtc
gcggtccgat 300tgcgaggcca tctgcaagct cggtcttaag gccaagattc
tcactcacat ccgatgccac 360atggacgacg caagactcgc tgtctccacc
ggtgtcgatg gtgtcgatgt cgtcattggt 420acctcccagt tcctgcgaca
gtactcccac ggcaaggaca tgaactacat tgcacagtcc 480gctgtcgagg
tcattgagtt tgtcaagagc cacggcattg agatccgatt ctcctccgag
540gattctttcc gatccgacct ggtcgatctc ctcaacatct accgaactgt
cgacaagatt 600ggtgtcaacc gagtcggtat tgctgacact gttggatgcg
ccaacccccg acaggtctac 660gagcttgtcc gaaccctcaa gtccgttgtc
tcgtgcgaca ttgagtgcca tttccacaac 720gacaccggct gtgccattgc
caacgcctac accgccctcg aggctggtgc caacctcatc 780gatgtctccg
ttctcggtat cggtgagcga aacggtatca cctctctcgg tggtctgatg
840gctcgaatga ttgctgctga ccgagactac gttctctcca agtacaagct
gcacaagctg 900cgagacctcg agaacctcgt cgccgacgcc gtccaggtca
acatcccctt caacaacccc 960atcaccggtt tctgcgcctt cacccacaag
gccggtatcc acgccaaggc cattctcgcc 1020aacccctcca cttacgagat
tctcaacccc gccgatttcg gtctgacccg atacatccac 1080tttgccaacc
gtcttaccgg ctggaacgcc atcaagtcgc gagttgacca gctcaacctg
1140cacctgaccg acgcccagtg caaggatgtc actgccaaga tcaagaagct
tggtgacgtt 1200cgatctctca acattgacga tgttgactcc atcatccgag
agttccacgc cgatgtcacc 1260agcactccca ccgttgctgc caccgaggga
cctgccgttg aggacgagcc cgccgccaag 1320aaggccaaga ctgaagagta a
134150446PRTYarrowia lipolytica 50Met Cys Ala Thr Asp Asn Ala Pro
Ala Ala Asn Ala Ala Pro Glu Lys 1 5 10 15 Pro Ser Asn Val Gly Val
Glu Val Gly His Thr Gly Glu Gln Thr Asn 20 25 30 Pro Tyr Gly Ala
Asn Pro Ala Asp Phe Leu Ser Asn Val Ser Lys Phe 35 40 45 Gln Leu
Ile Glu Ser Thr Leu Arg Glu Gly Glu Gln Phe Ala Ser Ala 50 55 60
Phe Phe Asp Thr Glu Thr Lys Ile Glu Ile Ala Lys Ala Leu Asp Asp 65
70 75 80 Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser Pro Ala Ala Ser
Glu Gln 85 90 95 Ser Arg Ser Asp Cys Glu Ala Ile Cys Lys Leu Gly
Leu Lys Ala Lys 100 105 110 Ile Leu Thr His Ile Arg Cys His Met Asp
Asp Ala Arg Leu Ala Val 115 120 125 Ser Thr Gly Val Asp Gly Val Asp
Val Val Ile Gly Thr Ser Gln Phe 130 135 140 Leu Arg Gln Tyr Ser His
Gly Lys Asp Met Asn Tyr Ile Ala Gln Ser 145 150 155 160 Ala Val Glu
Val Ile Glu Phe Val Lys Ser His Gly Ile Glu Ile Arg 165 170 175 Phe
Ser Ser Glu Asp Ser Phe Arg Ser Asp Leu Val Asp Leu Leu Asn 180 185
190 Ile Tyr Arg Thr Val Asp Lys Ile Gly Val Asn Arg Val Gly Ile Ala
195 200 205 Asp Thr Val Gly Cys Ala Asn Pro Arg Gln Val Tyr Glu Leu
Val Arg 210 215 220 Thr Leu Lys Ser Val Val Ser Cys Asp Ile Glu Cys
His Phe His Asn 225 230 235 240 Asp Thr Gly Cys Ala Ile Ala Asn Ala
Tyr Thr Ala Leu Glu Ala Gly 245 250 255 Ala Asn Leu Ile Asp Val Ser
Val Leu Gly Ile Gly Glu Arg Asn Gly 260 265 270 Ile Thr Ser Leu Gly
Gly Leu Met Ala Arg Met Ile Ala Ala Asp Arg 275 280 285 Asp Tyr Val
Leu Ser Lys Tyr Lys Leu His Lys Leu Arg Asp Leu Glu 290 295 300 Asn
Leu Val Ala Asp Ala Val Gln Val Asn Ile Pro Phe Asn Asn Pro 305 310
315 320 Ile Thr Gly Phe Cys Ala Phe Thr His Lys Ala Gly Ile His Ala
Lys 325 330 335 Ala Ile Leu Ala Asn Pro Ser Thr Tyr Glu Ile Leu Asn
Pro Ala Asp 340 345 350 Phe Gly Leu Thr Arg Tyr Ile His Phe Ala Asn
Arg Leu Thr Gly Trp 355 360 365 Asn Ala Ile Lys Ser Arg Val Asp Gln
Leu Asn Leu His Leu Thr Asp 370 375 380 Ala Gln Cys Lys Asp Val Thr
Ala Lys Ile Lys Lys Leu Gly Asp Val 385 390 395 400 Arg Ser Leu Asn
Ile Asp Asp Val Asp Ser Ile Ile Arg Glu Phe His 405 410 415 Ala Asp
Val Thr Ser Thr Pro Thr Val Ala Ala Thr Glu Gly Pro Ala 420 425 430
Val Glu Asp Glu Pro Ala Ala Lys Lys Ala Lys Thr Glu Glu 435 440 445
51 1728DNAYarrowia lipolytica 51atgccctacc tggccgatcc ctccaccaaa
tacaagccgt tccccccgat caatctgccc 60aaccggcagt ggccgtcgaa aacgctgcag
aagcccccgc ggtggctgtc gacggacctg 120cgggacggca accagtcgct
gccggatccc atgaccatgg cggagaagaa ggagtacttc 180cagaagattg
tcgacattgg ctacaaggag atcgaggtgg cgttcccgtc cgcctcgcag
240gtggactttg acttcacccg ctttgcctgc gacaccgccc ccgaagacgt
gtggatccag 300gtgctggctc cgtgccgaga ggatctcatc acccgaaccg
tcgagtccgt caagggcgcc 360aacaaggcca tcatccacat ctacctcgcc
acctccaagt gcttccggga cattgtcttc 420aaccattcgc gagaagaggc
cctggccaag gccgtggcat gcgccaagca cgtgcgagcc 480ctgaccaagg
actcggacga ccccgagtgc aaaaagacca cctggggttt tgagttctcc
540cccgagacct tctccgacac cgacgtggac tacgccattg aggtctgtga
ggccgtgaag 600gccgcctggg gcccctccga ggagaacccc atcattttca
acctccccgc caccgtcgaa 660atggccaccc ccaacatcta cgccgaccag
attgagtact ttgccaccaa catttccgag 720cgggagaaga tttgcatttc
tctgcacccc cacaacgacc gaggttgtgc cgtggctgct 780gccgagctgg
gccagatggc cggagccgac cgagtcgagg gctgtctgtt tggcaacggc
840gagcgaaccg gaaacgtcga cctcgtcact ctgggtctga atttgtacac
ccagggcgtg 900catcccaaga ttgacttctc cgacatcacc tcgatcatcg
acattgtgga gcgatgcaac 960aagatccccg tgcacccccg agctccctac
ggcggccagc tggtggtgtg tgccttctcc 1020ggctctcacc aggacgccat
caagaagggc tttgctcgaa tcgaagacgt caaggatgag 1080gtggccgagg
gcaagcgaca gtggcagatc ccctacctgc ctcttgaccc caaggacatt
1140ggccgaacct acgaggcagt cattcgagtc aattcgcagt ccggcaaggg
aggagccgcc 1200tggatcattc tgcgatctct ggagctcgat ctgccccgag
gcctgcaggt tgccttctcc 1260aaggtggtcc agaaggaggc cgaggtggtt
ggacaggagc tgtctgccca gcagttggtg 1320gatctctttg agcgagagta
cggcgtgttt gaggagcagc agggcaagta ccagctggac 1380gactttgagg
tgaccaacaa gtccaaggag gagcgagagc tgaccggagc tctgaccgtc
1440gagggcaagc gagtcgagct caagggtacc ggtaacggtc ccatttcgtc
cttcctggat 1500gccatcaaga acgcctttgg ctacaacctc gaggttctca
actaccacga gcactccatt 1560ggtaagggtt ccaagaccaa ggctgctact
tacattgagc tggcctatga ggaggacggc 1620aagacttcca agcgatgggg
tgttggtatt gacgaggatg tttcccaggc ttctattcat 1680gctattctgt
ctgccatgaa cgccattagc gagtcctaca agaaataa 172852575PRTYarrowia
lipolytica 52Met Pro Tyr Leu Ala Asp Pro Ser Thr Lys Tyr Lys Pro
Phe Pro Pro 1 5 10 15 Ile Asn Leu Pro Asn Arg Gln Trp Pro Ser Lys
Thr Leu Gln Lys Pro 20 25 30 Pro Arg Trp Leu Ser Thr Asp Leu Arg
Asp Gly Asn Gln Ser Leu Pro 35 40 45 Asp Pro Met Thr Met Ala Glu
Lys Lys Glu Tyr Phe Gln Lys Ile Val 50 55 60 Asp Ile Gly Tyr Lys
Glu Ile Glu Val Ala Phe Pro Ser Ala Ser Gln 65 70 75 80 Val Asp Phe
Asp Phe Thr Arg Phe Ala Cys Asp Thr Ala Pro Glu Asp 85 90 95 Val
Trp Ile Gln Val Leu Ala Pro Cys Arg Glu Asp Leu Ile Thr Arg 100 105
110 Thr Val Glu Ser Val Lys Gly Ala Asn Lys Ala Ile Ile His Ile Tyr
115 120 125 Leu Ala Thr Ser Lys Cys Phe Arg Asp Ile Val Phe Asn His
Ser Arg 130 135 140 Glu Glu Ala Leu Ala Lys Ala Val Ala Cys Ala Lys
His Val Arg Ala 145 150 155 160 Leu Thr Lys Asp Ser Asp Asp Pro Glu
Cys Lys Lys Thr Thr Trp Gly 165 170 175 Phe Glu Phe Ser Pro Glu Thr
Phe Ser Asp Thr Asp Val Asp Tyr Ala 180 185 190 Ile Glu Val Cys Glu
Ala Val Lys Ala Ala Trp Gly Pro Ser Glu Glu 195 200 205 Asn Pro Ile
Ile Phe Asn Leu Pro Ala Thr Val Glu Met Ala Thr Pro 210 215 220 Asn
Ile Tyr Ala Asp Gln Ile Glu Tyr Phe Ala Thr Asn Ile Ser Glu 225 230
235 240 Arg Glu Lys Ile Cys Ile Ser Leu His Pro His Asn Asp Arg Gly
Cys 245 250 255 Ala Val Ala Ala Ala Glu Leu Gly Gln Met Ala Gly Ala
Asp Arg Val 260 265 270 Glu Gly Cys Leu Phe Gly Asn Gly Glu Arg Thr
Gly Asn Val Asp Leu 275 280 285 Val Thr Leu Gly Leu Asn Leu Tyr Thr
Gln Gly Val His Pro Lys Ile 290 295 300 Asp Phe Ser Asp Ile Thr Ser
Ile Ile Asp Ile Val Glu Arg Cys Asn 305 310 315 320 Lys Ile Pro Val
His Pro Arg Ala Pro Tyr Gly Gly Gln Leu Val Val 325 330 335 Cys Ala
Phe Ser Gly Ser His Gln Asp Ala Ile Lys Lys Gly Phe Ala 340 345 350
Arg Ile Glu Asp Val Lys Asp Glu Val Ala Glu Gly Lys Arg Gln Trp 355
360 365 Gln Ile Pro Tyr Leu Pro Leu Asp Pro Lys Asp Ile Gly Arg Thr
Tyr 370 375 380 Glu Ala Val Ile Arg Val Asn Ser Gln Ser Gly Lys Gly
Gly Ala Ala 385 390 395 400 Trp Ile Ile Leu Arg Ser Leu Glu Leu Asp
Leu Pro Arg Gly Leu Gln 405 410 415 Val Ala Phe Ser Lys Val Val Gln
Lys Glu Ala Glu Val Val Gly Gln 420 425 430 Glu Leu Ser Ala Gln Gln
Leu Val Asp Leu Phe Glu Arg Glu Tyr Gly 435 440 445 Val Phe Glu Glu
Gln Gln Gly Lys Tyr Gln Leu Asp Asp Phe Glu Val 450 455 460 Thr Asn
Lys Ser Lys Glu Glu Arg Glu Leu Thr Gly Ala Leu Thr Val 465 470 475
480 Glu Gly Lys Arg Val Glu Leu Lys Gly Thr Gly Asn Gly Pro Ile Ser
485 490 495 Ser Phe Leu Asp Ala Ile Lys Asn Ala Phe Gly Tyr Asn Leu
Glu Val 500 505 510 Leu Asn Tyr His Glu His Ser Ile Gly Lys Gly Ser
Lys Thr Lys Ala 515 520 525 Ala Thr Tyr Ile Glu Leu Ala Tyr Glu Glu
Asp Gly Lys Thr Ser Lys 530 535 540 Arg Trp Gly Val Gly Ile Asp Glu
Asp Val Ser Gln Ala Ser Ile His 545 550 555 560 Ala Ile Leu Ser Ala
Met Asn Ala Ile Ser Glu Ser Tyr Lys Lys 565 570 575 531716DNAPichia
stipitis 53atgttaaagg atccttccac caaatatgct gcctttaaag gagtcaagtt
ggacaagaga 60acctggccct caaagtctat caccaaggct cctaggtggt tatctactga
tttaagagat 120ggtaaccaag cgttgcctga tcccatgtct gtcgaagaga
agaaggagta ttttcacaag 180ctcttggaga tcggattcaa agaaatcgag
gtatctttcc cttctgcatc tcaaacagat 240tttgacttca ccagatatgc
tgtggagaac gcaccagatg atgtttcgat ccaagttttg 300actcagtcta
gagaaccttt gatcagaaga actgttgaat ccgtaaaggg tgctaagaag
360gctaccatac atacatactt ggctacttct gacgttttcc gtgatgttgt
tttcaacatg 420tcacaagaag atgcaattgc caaagccatt gaaactacca
agttggtcaa gtctttgaca 480aaggacgatc cagaaatgca ggaaaccgag
tggaccttgg aattctctcc tgaatgcttc 540tcagatactc ctaccgaatt
tgctgtgcaa atttgtgaag cagtcaagaa cgtctgggag 600ccaactgtag
agaatcctat cattttcaac ttgccagcta ccgttgaagt tgcttctcca
660aacgtctacg ctgaccagat cgaatacttt gctacccaca tttccgaacg
tgaaaaggtg 720tgtatttctc ttcatgctca caatgaccgt ggctgcggtg
ttgctgcctc ggaattaggt 780ttattggctg gcggagacag agtcgaaggt
tgtttgtttg gaaacggtga aagaaccggt 840aacgtagact tgatcactgt
tgctctcaac atgtacacca atggagttgc accggagttg 900gacttttcag
aaatcgaaaa gctcatcgag gtcagtgaaa gatgtaacaa aatcccagtt
960cacccaagag ctccatactc tggatccttg gtcgtttgtg ccttctctgg
ttctcaccaa 1020gatgctatca agaagggatt ctccaaggct gaagccagag
ctgctagggg tgacaccaaa 1080tgggccattc catacttgcc attagaccct
aaggatatcg gtagaaacta cgaggccgtt 1140atcagagtca actctcaatc
tggtaaggga ggtgctgcct gggtcatctt gagatctctc 1200ggcttggact
tgccaagaca cttgcaagtt gtcttttctg gtattgttca ggaaagagct
1260gactctttgg gtagagaatt gaagtctgaa gagattgccg ctttgttcaa
cgagcagtac 1320tgctctactt ccaacttgtc tgtcaaggac ttcgagataa
ctaagagaaa gaatgctcca 1380gagaacaagg accgtgagat ctttgctgtc
ttgcaggctg gatccaagac cgttgacgtc 1440agtggacaag gtaacggacc
tatttcggcc tttgtggatg ccatatccaa gaaatacggt 1500gtttcctttg
aagtcgtcaa ctacagtgaa cacagtttag gcagtggtac ccagagtaag
1560gctgctactt acattgagtt agcctacaac aactctaaca acgagcatgt
tacaaagtgg 1620ggatgcggca ttaacacaga tgtgtcgcag gcttcgatgg
aggccattct ttctgttgtg 1680aactcattga ttgatagcaa ggaaattaat ttgtag
171654571PRTPichia stipitis 54Met Leu Lys Asp Pro Ser Thr Lys Tyr
Ala Ala Phe Lys Gly Val Lys 1 5 10 15 Leu Asp Lys Arg Thr Trp Pro
Ser Lys Ser Ile Thr Lys Ala Pro Arg 20 25 30 Trp Leu Ser Thr Asp
Leu Arg Asp Gly Asn Gln Ala Leu Pro Asp Pro 35 40 45 Met Ser Val
Glu Glu Lys Lys Glu Tyr Phe His Lys Leu Leu Glu Ile 50 55 60 Gly
Phe Lys Glu Ile Glu Val Ser Phe Pro Ser Ala Ser Gln Thr Asp 65 70
75 80 Phe Asp Phe Thr Arg Tyr Ala Val Glu Asn Ala Pro Asp Asp Val
Ser 85 90 95 Ile Gln Val Leu Thr Gln Ser Arg Glu Pro Leu Ile Arg
Arg Thr Val 100 105 110 Glu Ser Val Lys Gly Ala Lys Lys Ala Thr Ile
His Thr Tyr Leu Ala 115 120 125 Thr Ser Asp Val Phe Arg Asp Val Val
Phe Asn Met Ser Gln Glu Asp 130 135 140 Ala Ile Ala Lys Ala Ile Glu
Thr Thr Lys Leu Val Lys Ser Leu Thr 145 150 155 160 Lys Asp Asp Pro
Glu Met Gln Glu Thr Glu Trp Thr Leu Glu Phe Ser 165 170 175 Pro Glu
Cys Phe Ser Asp Thr Pro Thr Glu Phe Ala Val Gln Ile Cys 180 185 190
Glu Ala Val Lys Asn Val Trp Glu Pro Thr Val Glu Asn Pro Ile Ile 195
200 205 Phe Asn Leu Pro Ala Thr Val Glu Val Ala Ser Pro Asn Val Tyr
Ala 210 215 220 Asp Gln Ile Glu Tyr Phe Ala Thr His Ile Ser Glu Arg
Glu Lys Val 225 230 235 240 Cys Ile Ser Leu His Ala His Asn Asp Arg
Gly Cys Gly Val Ala Ala 245 250 255 Ser Glu Leu Gly Leu Leu Ala Gly
Gly Asp Arg Val Glu Gly Cys Leu 260 265 270 Phe Gly Asn Gly Glu Arg
Thr Gly Asn Val Asp Leu Ile Thr Val Ala 275 280 285 Leu Asn Met Tyr
Thr Asn Gly Val Ala Pro Glu Leu Asp Phe Ser Glu 290 295 300 Ile Glu
Lys Leu Ile Glu Val Ser Glu Arg Cys Asn Lys Ile Pro Val 305 310 315
320 His Pro Arg Ala Pro Tyr Ser Gly Ser Leu Val Val Cys Ala Phe Ser
325 330 335 Gly Ser His Gln Asp Ala Ile Lys Lys Gly Phe Ser Lys Ala
Glu Ala 340 345 350 Arg Ala Ala Arg Gly Asp Thr Lys Trp Ala Ile Pro
Tyr Leu Pro Leu 355 360 365 Asp Pro Lys Asp Ile Gly Arg Asn Tyr Glu
Ala Val Ile Arg Val Asn 370 375 380 Ser Gln Ser Gly Lys Gly Gly Ala
Ala Trp Val Ile Leu Arg Ser Leu 385 390 395 400 Gly Leu Asp Leu Pro
Arg His Leu Gln Val Val Phe Ser Gly Ile Val 405 410 415 Gln Glu Arg
Ala Asp Ser Leu Gly Arg Glu Leu Lys Ser Glu Glu Ile 420 425 430 Ala
Ala Leu Phe Asn Glu Gln Tyr Cys Ser Thr Ser Asn Leu Ser Val 435 440
445 Lys Asp Phe Glu Ile Thr Lys Arg Lys Asn Ala Pro Glu Asn Lys Asp
450 455 460 Arg Glu Ile Phe Ala Val Leu Gln Ala Gly Ser Lys Thr Val
Asp Val 465 470 475 480 Ser Gly Gln Gly Asn Gly Pro Ile Ser Ala Phe
Val Asp Ala Ile Ser 485 490 495 Lys Lys Tyr Gly Val Ser Phe Glu Val
Val Asn Tyr Ser Glu His Ser 500 505 510 Leu Gly Ser Gly Thr Gln Ser
Lys Ala Ala Thr Tyr Ile Glu Leu Ala 515 520 525 Tyr Asn Asn Ser Asn
Asn Glu His Val Thr Lys Trp Gly Cys Gly Ile 530 535 540 Asn Thr Asp
Val Ser Gln Ala Ser Met Glu Ala Ile Leu Ser Val Val 545 550 555 560
Asn Ser Leu Ile Asp Ser Lys Glu Ile Asn Leu 565 570 551728DNAPichia
stipitis 55atgcctatgt tagctgatcc atcccaaaag tacaagcctt tccctcctgt
acatttaccc 60aatcgtcaat ggccatctcg tacgcttgaa aaaccaccta gatggctttc
caccgacttg 120agagatggaa accagtcctt accagatccc atgtcaattg
ctgaaaagaa ggagtacttc 180aagaagttgg tagatattgg tttcaaggaa
atcgaagtgg cctttccttc ggcatcgcag 240atcgactttg acttcaccag
attcgctgtg gaaacagctc cagcagacgt tgctgtccag 300gtcttgtctc
cctgtagaga ggacttgatc aagcgtactg tagagtcgtt gaccggagcc
360aaaaaggcta ttgtgcacat atacttggct acgtcggact gcttccgtaa
cgtagtcttt 420ggattaacca aggaagagtc gaaggctctt gccgtaaaat
gcgccaagtt ggtcagatct 480ttgactaaag atgaccccaa gcaacaagca
actgagtggg actttgagtt ctcgccagaa 540accttttcag acaccgatat
ggactacgct gtagaggtct gcgaagccgt caaggaggcc 600tggggcccta
ctgaagacag acctatcatc ttcaacttgc cagctaccgt ggaaatggct
660actccaaaca tatatgccga ccagatcgag tactttgcta ctcacatctc
ggaaagagaa 720aagatcgcaa tttcgttaca tccccacaac gacagaggat
gttctgttgc tgccgctgag 780ctcggccagt tagctggtgc tgacagagtt
gagggatgct tatttggaaa tggagaaaga 840acaggtaacg ttgacttggt
caccttggct ctcaacttgt atactcaggg tgtttcacct 900aagcttgact
tctccgatat caactctgtt atcgacgtag tagaaaagtg taacaagatt
960cctgttcatg caagagctcc ttatggaggt gcccttgtcg
tttgtgcctt cagtggatcg 1020caccaagacg ccatcaagaa aggtttcaat
gtgcacgaga agaaggtcga agctgctgca 1080ggaaaacatg tccactggca
gttaccctac ttgccattgg accctcagga tattggcaga 1140acttacgagg
ccatcatcag agtcaactcg cagtctggta agggtggttc cgcttgggtc
1200atcttgagaa acttggagct cgacttgccc agaggattgc aagtggcttt
ctccaaggtg 1260gttcaacagc gtgctgaagt caagggtcag gagttgacca
acgaagaatt gtgtgacttg 1320ttcaagcaag aatactacat tgactacgag
ggtgacaact tcaacgacca gacctacaag 1380ttgatcgact actccatcct
gactcctgcc aagggccaga aggaaattga agccgaaatc 1440cagatcgatg
acaagatcgt caagatcaag ggccagggta acggtcagct ttcggctttc
1500aatgctgccc tctccaaaca cctcaacatc gacttaaacg tcaagcacta
ccacgaacac 1560tcattgggtg tagactcgaa ttctcgtgca gccacctaca
tcgaagtctc actcaaaaac 1620gacaacgtca ccagatgggg tgtgggtatc
catgaagatg tctcgcaagc ttctttctta 1680tctctcatct ccatcttgaa
cggcttgcac agaaacaagg atatttag 172856575PRTPichia stipitis 56Met
Pro Met Leu Ala Asp Pro Ser Gln Lys Tyr Lys Pro Phe Pro Pro 1 5 10
15 Val His Leu Pro Asn Arg Gln Trp Pro Ser Arg Thr Leu Glu Lys Pro
20 25 30 Pro Arg Trp Leu Ser Thr Asp Leu Arg Asp Gly Asn Gln Ser
Leu Pro 35 40 45 Asp Pro Met Ser Ile Ala Glu Lys Lys Glu Tyr Phe
Lys Lys Leu Val 50 55 60 Asp Ile Gly Phe Lys Glu Ile Glu Val Ala
Phe Pro Ser Ala Ser Gln 65 70 75 80 Ile Asp Phe Asp Phe Thr Arg Phe
Ala Val Glu Thr Ala Pro Ala Asp 85 90 95 Val Ala Val Gln Val Leu
Ser Pro Cys Arg Glu Asp Leu Ile Lys Arg 100 105 110 Thr Val Glu Ser
Leu Thr Gly Ala Lys Lys Ala Ile Val His Ile Tyr 115 120 125 Leu Ala
Thr Ser Asp Cys Phe Arg Asn Val Val Phe Gly Leu Thr Lys 130 135 140
Glu Glu Ser Lys Ala Leu Ala Val Lys Cys Ala Lys Leu Val Arg Ser 145
150 155 160 Leu Thr Lys Asp Asp Pro Lys Gln Gln Ala Thr Glu Trp Asp
Phe Glu 165 170 175 Phe Ser Pro Glu Thr Phe Ser Asp Thr Asp Met Asp
Tyr Ala Val Glu 180 185 190 Val Cys Glu Ala Val Lys Glu Ala Trp Gly
Pro Thr Glu Asp Arg Pro 195 200 205 Ile Ile Phe Asn Leu Pro Ala Thr
Val Glu Met Ala Thr Pro Asn Ile 210 215 220 Tyr Ala Asp Gln Ile Glu
Tyr Phe Ala Thr His Ile Ser Glu Arg Glu 225 230 235 240 Lys Ile Ala
Ile Ser Leu His Pro His Asn Asp Arg Gly Cys Ser Val 245 250 255 Ala
Ala Ala Glu Leu Gly Gln Leu Ala Gly Ala Asp Arg Val Glu Gly 260 265
270 Cys Leu Phe Gly Asn Gly Glu Arg Thr Gly Asn Val Asp Leu Val Thr
275 280 285 Leu Ala Leu Asn Leu Tyr Thr Gln Gly Val Ser Pro Lys Leu
Asp Phe 290 295 300 Ser Asp Ile Asn Ser Val Ile Asp Val Val Glu Lys
Cys Asn Lys Ile 305 310 315 320 Pro Val His Ala Arg Ala Pro Tyr Gly
Gly Ala Leu Val Val Cys Ala 325 330 335 Phe Ser Gly Ser His Gln Asp
Ala Ile Lys Lys Gly Phe Asn Val His 340 345 350 Glu Lys Lys Val Glu
Ala Ala Ala Gly Lys His Val His Trp Gln Leu 355 360 365 Pro Tyr Leu
Pro Leu Asp Pro Gln Asp Ile Gly Arg Thr Tyr Glu Ala 370 375 380 Ile
Ile Arg Val Asn Ser Gln Ser Gly Lys Gly Gly Ser Ala Trp Val 385 390
395 400 Ile Leu Arg Asn Leu Glu Leu Asp Leu Pro Arg Gly Leu Gln Val
Ala 405 410 415 Phe Ser Lys Val Val Gln Gln Arg Ala Glu Val Lys Gly
Gln Glu Leu 420 425 430 Thr Asn Glu Glu Leu Cys Asp Leu Phe Lys Gln
Glu Tyr Tyr Ile Asp 435 440 445 Tyr Glu Gly Asp Asn Phe Asn Asp Gln
Thr Tyr Lys Leu Ile Asp Tyr 450 455 460 Ser Ile Ser Thr Pro Ala Lys
Gly Gln Lys Glu Ile Glu Ala Glu Ile 465 470 475 480 Gln Ile Asp Asp
Lys Ile Val Lys Ile Lys Gly Gln Gly Asn Gly Gln 485 490 495 Leu Ser
Ala Phe Asn Ala Ala Leu Ser Lys His Leu Asn Ile Asp Leu 500 505 510
Asn Val Lys His Tyr His Glu His Ser Leu Gly Val Asp Ser Asn Ser 515
520 525 Arg Ala Ala Thr Tyr Ile Glu Val Ser Leu Lys Asn Asp Asn Val
Thr 530 535 540 Arg Trp Gly Val Gly Ile His Glu Asp Val Ser Gln Ala
Ser Phe Leu 545 550 555 560 Ser Leu Ile Ser Ile Leu Asn Gly Leu His
Arg Asn Lys Asp Ile 565 570 575 571101DNASaccharomyces cerevisiae
57atgttttcca gactgccaac atcattggcc agaaatgttg cacgtcgtgc cccaacttct
60tttgtaagac cctctgcagc agcagcagca ttgagattct catcaacaaa gacgatgacc
120gtcagagagg ccttgaatag tgccatggcg gaagaattgg accgtgatga
tgatgtcttc 180cttattggtg aagaagttgc acaatataac ggggcttata
aggtgtcaaa gggtttattg 240gacaggttcg gtgaacgtcg tgtggttgac
acacctatta ccgaatacgg gttcacaggt 300ttggccgttg gtgccgcttt
gaagggtttg aagccaattg tagagtttat gtcgttcaat 360ttctctatgc
aagctatcga tcatgttgtc aattccgctg caaagactca ctacatgtct
420ggtggtactc aaaaatgtca aatggtcttc agaggtccta atggtgctgc
agtgggtgtt 480ggtgctcaac attcacagga cttttctcct tggtacggtt
ccattccagg gttaaaggtc 540cttgtccctt attctgctga agatgctagg
ggtttgttaa aggccgccat cagagatcca 600aaccctgttg tatttttaga
gaacgaattg ttgtacggtg aatcttttga aatctcagaa 660gaagctttat
cccctgagtt caccttgcca tacaaggcta agatcgaaag agaaggtacc
720gatatttcca ttgttacgta cacaagaaac gttcagtttt ctttggaagc
cgctgaaatt 780ctacaaaaga aatatggtgt ctctgcagaa gttatcaact
tgcgttctat tagaccttta 840gatactgaag ctatcatcaa aactgtcaag
aagacaaacc acttgattac tgttgaatcc 900actttcccat catttggtgt
tggtgctgaa attgtcgccc aagttatgga gtctgaagcc 960tttgattact
tggatgctcc aatccaaaga gttactggtg ccgatgttcc aacaccttac
1020gctaaagaat tagaagattt cgctttccct gatactccaa ccatcgttaa
agctgtcaaa 1080gaagtcttgt caattgaata a 110158366PRTSaccharomyces
cerevisiae 58Met Phe Ser Arg Leu Pro Thr Ser Leu Ala Arg Asn Val
Ala Arg Arg 1 5 10 15 Ala Pro Thr Ser Phe Val Arg Pro Ser Ala Ala
Ala Ala Ala Leu Arg 20 25 30 Phe Ser Ser Thr Lys Thr Met Thr Val
Arg Glu Ala Leu Asn Ser Ala 35 40 45 Met Ala Glu Glu Leu Asp Arg
Asp Asp Asp Val Phe Leu Ile Gly Glu 50 55 60 Glu Val Ala Gln Tyr
Asn Gly Ala Tyr Lys Val Ser Lys Gly Leu Leu 65 70 75 80 Asp Arg Phe
Gly Glu Arg Arg Val Val Asp Thr Pro Ile Thr Glu Tyr 85 90 95 Gly
Phe Thr Gly Leu Ala Val Gly Ala Ala Leu Lys Gly Leu Lys Pro 100 105
110 Ile Val Glu Phe Met Ser Phe Asn Phe Ser Met Gln Ala Ile Asp His
115 120 125 Val Val Asn Ser Ala Ala Lys Thr His Tyr Met Ser Gly Gly
Thr Gln 130 135 140 Lys Cys Gln Met Val Phe Arg Gly Pro Asn Gly Ala
Ala Val Gly Val 145 150 155 160 Gly Ala Gln His Ser Gln Asp Phe Ser
Pro Trp Tyr Gly Ser Ile Pro 165 170 175 Gly Leu Lys Val Leu Val Pro
Tyr Ser Ala Glu Asp Ala Arg Gly Leu 180 185 190 Leu Lys Ala Ala Ile
Arg Asp Pro Asn Pro Val Val Phe Leu Glu Asn 195 200 205 Glu Leu Leu
Tyr Gly Glu Ser Phe Glu Ile Ser Glu Glu Ala Leu Ser 210 215 220 Pro
Glu Phe Thr Leu Pro Tyr Lys Ala Lys Ile Glu Arg Glu Gly Thr 225 230
235 240 Asp Ile Ser Ile Val Thr Tyr Thr Arg Asn Val Gln Phe Ser Leu
Glu 245 250 255 Ala Ala Glu Ile Leu Gln Lys Lys Tyr Gly Val Ser Ala
Glu Val Ile 260 265 270 Asn Leu Arg Ser Ile Arg Pro Leu Asp Thr Glu
Ala Ile Ile Lys Thr 275 280 285 Val Lys Lys Thr Asn His Leu Ile Thr
Val Glu Ser Thr Phe Pro Ser 290 295 300 Phe Gly Val Gly Ala Glu Ile
Val Ala Gln Val Met Glu Ser Glu Ala 305 310 315 320 Phe Asp Tyr Leu
Asp Ala Pro Ile Gln Arg Val Thr Gly Ala Asp Val 325 330 335 Pro Thr
Pro Tyr Ala Lys Glu Leu Glu Asp Phe Ala Phe Pro Asp Thr 340 345 350
Pro Thr Ile Val Lys Ala Val Lys Glu Val Leu Ser Ile Glu 355 360 365
59 1101DNASchizosaccharomyces pombe 59atgattcgtc ttcaaaagtt
tggtgaaatt gttgggacca gtcgttcttg gaaacttctt 60agttcaacca tcgcaaagcg
ctattcttct tcttccaatg gagtgaagga aatgaccgtt 120cgtgatgctt
tgaacagtgc aatggaagaa gaaatgaaac gtgacgatcg tgtcttcttg
180attggcgaag aggttgcgca atacaatggt gcttataaga tatctagagg
tttattagac 240aagtttggtc ctaaacgtgt tatcgacact cccattactg
aaatgggttt tactggtttg 300gcaacaggtg ctgcttttgc tggtttacgt
cctatttgtg agtttatgac tttcaatttt 360tccatgcagg ctatcgatca
tatcgttaac tcggccgcca gaaccctgta catgtctggt 420ggtattcagg
cttgtcctat tgtcttccgt ggacctaatg ggcctgccgc tgcagttgct
480gctcagcatt ctcaacactt tgctccatgg tatggtagta tccctggtct
taaagtagtt 540tctccttact cagcagaaga tgctcgtggt ttgttgaagg
ctgctattcg tgatcctaat 600cccgttgttg tacttgaaaa cgaaattctt
tatggtaaaa cctttccaat ttcgaaagaa 660gcgttgagcg aggactttgt
gcttcccttt ggccttgcta aggtggagcg ccccggtaaa 720gatatcacca
tcgttggtga gtctatttct gttgttactg ctttagaagc agctgacaag
780ctcaaggctg actatggtgt tgaagctgaa gttataaact tgcgtagtat
tcgtccttta 840gacatcaata ctatcgcggc cagtgttaag aagacaaatc
gtattgtgac tgttgaccag 900gcatatagtc aacatggtat tggtagtgaa
attgctgctc aaattatgga gtctgacgca 960tttgattatc ttgatgctcc
tgttgaacgt gtaagtatgg cagatgttcc catgccttat 1020agtcatcctg
ttgaggctgc ttctgtccca aatgccgatg ttgttgttgc tgctgctaaa
1080aaatgcttgt atattaaata a 110160366PRTSchizosaccharomyces pombe
60Met Ile Arg Leu Gln Lys Phe Gly Glu Ile Val Gly Thr Ser Arg Ser 1
5 10 15 Trp Lys Leu Leu Ser Ser Thr Ile Ala Lys Arg Tyr Ser Ser Ser
Ser 20 25 30 Asn Gly Val Lys Glu Met Thr Val Arg Asp Ala Leu Asn
Ser Ala Met 35 40 45 Glu Glu Glu Met Lys Arg Asp Asp Arg Val Phe
Leu Ile Gly Glu Glu 50 55 60 Val Ala Gln Tyr Asn Gly Ala Tyr Lys
Ile Ser Arg Gly Leu Leu Asp 65 70 75 80 Lys Phe Gly Pro Lys Arg Val
Ile Asp Thr Pro Ile Thr Glu Met Gly 85 90 95 Phe Thr Gly Leu Ala
Thr Gly Ala Ala Phe Ala Gly Leu Arg Pro Ile 100 105 110 Cys Glu Phe
Met Thr Phe Asn Phe Ser Met Gln Ala Ile Asp His Ile 115 120 125 Val
Asn Ser Ala Ala Arg Thr Leu Tyr Met Ser Gly Gly Ile Gln Ala 130 135
140 Cys Pro Ile Val Phe Arg Gly Pro Asn Gly Pro Ala Ala Ala Val Ala
145 150 155 160 Ala Gln His Ser Gln His Phe Ala Pro Trp Tyr Gly Ser
Ile Pro Gly 165 170 175 Leu Lys Val Val Ser Pro Tyr Ser Ala Glu Asp
Ala Arg Gly Leu Leu 180 185 190 Lys Ala Ala Ile Arg Asp Pro Asn Pro
Val Val Val Leu Glu Asn Glu 195 200 205 Ile Leu Tyr Gly Lys Thr Phe
Pro Ile Ser Lys Glu Ala Leu Ser Glu 210 215 220 Asp Phe Val Leu Pro
Phe Gly Leu Ala Lys Val Glu Arg Pro Gly Lys 225 230 235 240 Asp Ile
Thr Ile Val Gly Glu Ser Ile Ser Val Val Thr Ala Leu Glu 245 250 255
Ala Ala Asp Lys Leu Lys Ala Asp Tyr Gly Val Glu Ala Glu Val Ile 260
265 270 Asn Leu Arg Ser Ile Arg Pro Leu Asp Ile Asn Thr Ile Ala Ala
Ser 275 280 285 Val Lys Lys Thr Asn Arg Ile Val Thr Val Asp Gln Ala
Tyr Ser Gln 290 295 300 His Gly Ile Gly Ser Glu Ile Ala Ala Gln Ile
Met Glu Ser Asp Ala 305 310 315 320 Phe Asp Tyr Leu Asp Ala Pro Val
Glu Arg Val Ser Met Ala Asp Val 325 330 335 Pro Met Pro Tyr Ser His
Pro Val Glu Ala Ala Ser Val Pro Asn Ala 340 345 350 Asp Val Val Val
Ala Ala Ala Lys Lys Cys Leu Tyr Ile Lys 355 360 365 61
1140DNACandida albicans 61atgtcatcat tatcatcagt caccaggagt
gctaaattag ccactcaatc tttgaaatac 60aacactagac catcattatc taaaattggt
caatttcaaa catcaaaaat cacttatcgt 120gccaattcca cacaatcaac
tcctgtcaaa gaaattactg tcagagatgc tcttaaccaa 180gctttatctg
aagaattaga cagagatgaa gatgttttcc ttatgggtga agaagttgcc
240caatacaatg gtgcctataa agtcagtaga ggattattgg acaaatttgg
tgaaaagaga 300gttattgaca ctccaattac tgaaatgggg ttcactggat
tagctgttgg tgctgcttta 360catggtctta aaccagtttt ggaatttatg
acttggaatt ttgctatgca aggtattgat 420catattttaa attctgctgc
taaaactctt tatatgtctg gtggtaaaca accatgtaat 480ataactttcc
gtggtcctaa tggtgctgct gctggtgttg ctgctcaaca ttctcagtgt
540tatgctgctt ggtatggttc aattcctggt ttaaaagttt tatctcctta
ttctgctgaa 600gattataagg gtttacttaa agctgccatt agagatccta
acccagttgt tttcttggaa 660aatgaaattg cttatggtga aacttttaaa
gtttctgaag aattttcatc tccagatttc 720attttaccaa ttggtaaagc
caaaattgaa aaagaaggta ctgatttaac cattgttggt 780catagtcgtg
cccttaaatt tgccgttgaa gccgctgaaa ttttggaaaa agatttcgga
840attaaagctg aagtgctcaa tttaagatca attaaaccat tggatgttcc
agctattgtt 900gattcagtta aaaagactaa tcatttggtt actgttgaaa
atggattccc aggttttggt 960gttggttcag aaatttgtgc tcaaattatg
gaaagtgaag cctttgatta tttggatgct 1020ccagttgaaa gagttactgg
ttgtgaagtt ccaactccat atgctaaaga attggaagat 1080tttgctttcc
cagacactga agttatcttg agagcttgta aaaaagtatt aagtttgtaa
114062379PRTCandida albicans 62Met Ser Ser Leu Ser Ser Val Thr Arg
Ser Ala Lys Leu Ala Thr Gln 1 5 10 15 Ser Leu Lys Tyr Asn Thr Arg
Pro Ser Leu Ser Lys Ile Gly Gln Phe 20 25 30 Gln Thr Ser Lys Ile
Thr Tyr Arg Ala Asn Ser Thr Gln Ser Thr Pro 35 40 45 Val Lys Glu
Ile Thr Val Arg Asp Ala Leu Asn Gln Ala Leu Ser Glu 50 55 60 Glu
Leu Asp Arg Asp Glu Asp Val Phe Leu Met Gly Glu Glu Val Ala 65 70
75 80 Gln Tyr Asn Gly Ala Tyr Lys Val Ser Arg Gly Leu Leu Asp Lys
Phe 85 90 95 Gly Glu Lys Arg Val Ile Asp Thr Pro Ile Thr Glu Met
Gly Phe Thr 100 105 110 Gly Leu Ala Val Gly Ala Ala Leu His Gly Leu
Lys Pro Val Leu Glu 115 120 125 Phe Met Thr Trp Asn Phe Ala Met Gln
Gly Ile Asp His Ile Leu Asn 130 135 140 Ser Ala Ala Lys Thr Leu Tyr
Met Ser Gly Gly Lys Gln Pro Cys Asn 145 150 155 160 Ile Thr Phe Arg
Gly Pro Asn Gly Ala Ala Ala Gly Val Ala Ala Gln 165 170 175 His Ser
Gln Cys Tyr Ala Ala Trp Tyr Gly Ser Ile Pro Gly Leu Lys 180 185 190
Val Leu Ser Pro Tyr Ser Ala Glu Asp Tyr Lys Gly Leu Leu Lys Ala 195
200 205 Ala Ile Arg Asp Pro Asn Pro Val Val Phe Leu Glu Asn Glu Ile
Ala 210 215 220 Tyr Gly Glu Thr Phe Lys Val Ser Glu Glu Phe Ser Ser
Pro Asp Phe 225 230 235 240 Ile Leu Pro Ile Gly Lys Ala Lys Ile Glu
Lys Glu Gly Thr Asp Leu 245 250 255 Thr Ile Val Gly His Ser Arg Ala
Leu Lys Phe Ala Val Glu Ala Ala 260 265 270 Glu Ile Leu Glu Lys Asp
Phe Gly Ile Lys Ala Glu Val Leu Asn Leu 275 280 285 Arg Ser Ile Lys
Pro Leu Asp Val Pro Ala Ile Val Asp Ser Val Lys 290 295 300 Lys Thr
Asn His Leu Val Thr Val Glu Asn Gly Phe Pro Gly Phe Gly 305 310 315
320 Val Gly Ser Glu Ile Cys Ala Gln Ile Met Glu Ser
Glu Ala Phe Asp 325 330 335 Tyr Leu Asp Ala Pro Val Glu Arg Val Thr
Gly Cys Glu Val Pro Thr 340 345 350 Pro Tyr Ala Lys Glu Leu Glu Asp
Phe Ala Phe Pro Asp Thr Glu Val 355 360 365 Ile Leu Arg Ala Cys Lys
Lys Val Leu Ser Leu 370 375 631065DNAKluyveromyces lactis
63atgatgatgc tttctaacac ttttaagagg gctgttcctt ctgtggttca atccatgaga
60tttgcttcta ccaagaccat gaccgtcaga gaagctttga attctgccat ggccgaagaa
120atggaccgtg atgatgatgt tttcatcatt ggtgaagaag ttgctcaata
taatggtgct 180tacaaggtta ccaagggttt attggaccgt ttcggtgaaa
gaagagttgt tgacactcca 240attaccgaaa tgggtttcac tggtttggct
gttggtgccg ctttgaaggg tttaaagcca 300attgttgaat tcatgtcttt
caacttctcc atgcaagcta tggatcaagt cattaactcc 360gctgctaaga
cttactatat gtccggtggt actcagaaat gtcaaatcgt tttcagaggt
420ccaaacggtt ctgctgtcgg tgttgctgct caacattccc aagattattc
tgcttggtac 480ggttctgttc caggtatgaa ggttttggtt ccatactctg
ctgaagatgc tagaggtttg 540ttgaaggctg ccattcgtga tccaaaccca
gttgttttct tggaaaacga attgttatac 600ggtcaatctt tcgaagtctc
tgaagaatct ctgtctactg atttcacttt gccatacaaa 660gcaaaggttg
aaagagaagg ttctgatatc tctatcatca gttacaccag aaatgttcaa
720ttctctttgg aagctgctga aattttgtct aagcaatacg gtgtttctgc
tgaagttatc 780aatttgagag ccattagacc tttggatgtt gaagctatca
tcaacactgt caagaagacc 840aaccacttga ttactgttga atctactttc
ccagctttcg gtgttggtgc tgaaattatc 900gctcaaatta tggaatctga
agccttcgat tatttggatg ctccaattca aagagttact 960ggtgctgaag
tcccaactcc ttatgctaag gaattagaag attttgcttt cccagaccct
1020gacaccattg tcagagctgc taaaagtgtt ttgtctattg aatga
106564354PRTKluyveromyces lactis 64Met Met Met Leu Ser Asn Thr Phe
Lys Arg Ala Val Pro Ser Val Val 1 5 10 15 Gln Ser Met Arg Phe Ala
Ser Thr Lys Thr Met Thr Val Arg Glu Ala 20 25 30 Leu Asn Ser Ala
Met Ala Glu Glu Met Asp Arg Asp Asp Asp Val Phe 35 40 45 Ile Ile
Gly Glu Glu Val Ala Gln Tyr Asn Gly Ala Tyr Lys Val Thr 50 55 60
Lys Gly Leu Leu Asp Arg Phe Gly Glu Arg Arg Val Val Asp Thr Pro 65
70 75 80 Ile Thr Glu Met Gly Phe Thr Gly Leu Ala Val Gly Ala Ala
Leu Lys 85 90 95 Gly Leu Lys Pro Ile Val Glu Phe Met Ser Phe Asn
Phe Ser Met Gln 100 105 110 Ala Met Asp Gln Val Ile Asn Ser Ala Ala
Lys Thr Tyr Tyr Met Ser 115 120 125 Gly Gly Thr Gln Lys Cys Gln Ile
Val Phe Arg Gly Pro Asn Gly Ser 130 135 140 Ala Val Gly Val Ala Ala
Gln His Ser Gln Asp Tyr Ser Ala Trp Tyr 145 150 155 160 Gly Ser Val
Pro Gly Met Lys Val Leu Val Pro Tyr Ser Ala Glu Asp 165 170 175 Ala
Arg Gly Leu Leu Lys Ala Ala Ile Arg Asp Pro Asn Pro Val Val 180 185
190 Phe Leu Glu Asn Glu Leu Leu Tyr Gly Gln Ser Phe Glu Val Ser Glu
195 200 205 Glu Ser Leu Ser Thr Asp Phe Thr Leu Pro Tyr Lys Ala Lys
Val Glu 210 215 220 Arg Glu Gly Ser Asp Ile Ser Ile Ile Ser Tyr Thr
Arg Asn Val Gln 225 230 235 240 Phe Ser Leu Glu Ala Ala Glu Ile Leu
Ser Lys Gln Tyr Gly Val Ser 245 250 255 Ala Glu Val Ile Asn Leu Arg
Ala Ile Arg Pro Leu Asp Val Glu Ala 260 265 270 Ile Ile Asn Thr Val
Lys Lys Thr Asn His Leu Ile Thr Val Glu Ser 275 280 285 Thr Phe Pro
Ala Phe Gly Val Gly Ala Glu Ile Ile Ala Gln Ile Met 290 295 300 Glu
Ser Glu Ala Phe Asp Tyr Leu Asp Ala Pro Ile Gln Arg Val Thr 305 310
315 320 Gly Ala Glu Val Pro Thr Pro Tyr Ala Lys Glu Leu Glu Asp Phe
Ala 325 330 335 Phe Pro Asp Pro Asp Thr Ile Val Arg Ala Ala Lys Ser
Val Leu Ser 340 345 350 Ile Glu 65993DNAYarrowia lipolytica
65atgactgtca gagacgccct caacaccgca ctgcgagagg agatggaccg aaacgataat
60gttttcatca tgggtgagga ggtcggccag tacaacggtg cctacaaggt caccaagggc
120cttctcgaca agttcggcga gaagcgagtg gttgacaccc ctatcaccga
gatgggtttc 180gccggtgttt gtgtcggtgc cgccctggcc ggtctcaccc
ccgtctgcga gttcatgacc 240tggaacttcg ccatgcaggc cattgatcag
atcatcaatt ccggtgccaa gacctactac 300atgtccggag gtacccagca
gtgcaatgtc accttccgag gtcctaacgg tgccgccgct 360ggtgttgctg
cccaacactc tcaggatttc accgggtggt acggccagat tcccggtctc
420aaggtcgtct ctccctacag ctctgaggat gccaagggtc tgctcaaggc
cgccatccga 480gaccccaacg tgactgtttt cctcgagaac gagatcatgt
acggagagtc tttccccatg 540tctgaggagg ccatgtcccc cgacttcgtt
ctgccccttg gaaaggccaa gattgagcga 600gagggtaagg atatcactct
tgtcggtcac tcccgaaacg tcgagaccgc cctcaaggcc 660gccgacctcc
tcaagaagca ccacaacgtc gatgccgagg tcattaacct gcgaactgtc
720aagcctctcg acactgagac cattttcaac tccatcaaga agactaaccg
acttgtctct 780gtcgaggctg gcttccccgc ctttggcatg ggctccgagc
tctgtggtgt cgtcaacgac 840tcctgggcct gggattacct tgatgccccc
atccagcgag ttaccggagc tgaggttccc 900actccttacg ccattgagct
tgagaacttc gccttcccca cacccgagat tgttgtcaag 960gctgccaagg
acgccctcta cattgaggag tag 99366330PRTYarrowia lipolytica 66Met Thr
Val Arg Asp Ala Leu Asn Thr Ala Leu Arg Glu Glu Met Asp 1 5 10 15
Arg Asn Asp Asn Val Phe Ile Met Gly Glu Glu Val Gly Gln Tyr Asn 20
25 30 Gly Ala Tyr Lys Val Thr Lys Gly Leu Leu Asp Lys Phe Gly Glu
Lys 35 40 45 Arg Val Val Asp Thr Pro Ile Thr Glu Met Gly Phe Ala
Gly Val Cys 50 55 60 Val Gly Ala Ala Leu Ala Gly Leu Thr Pro Val
Cys Glu Phe Met Thr 65 70 75 80 Trp Asn Phe Ala Met Gln Ala Ile Asp
Gln Ile Ile Asn Ser Gly Ala 85 90 95 Lys Thr Tyr Tyr Met Ser Gly
Gly Thr Gln Gln Cys Asn Val Thr Phe 100 105 110 Arg Gly Pro Asn Gly
Ala Ala Ala Gly Val Ala Ala Gln His Ser Gln 115 120 125 Asp Phe Thr
Gly Trp Tyr Gly Gln Ile Pro Gly Leu Lys Val Val Ser 130 135 140 Pro
Tyr Ser Ser Glu Asp Ala Lys Gly Leu Leu Lys Ala Ala Ile Arg 145 150
155 160 Asp Pro Asn Val Thr Val Phe Leu Glu Asn Glu Ile Met Tyr Gly
Glu 165 170 175 Ser Phe Pro Met Ser Glu Glu Ala Met Ser Pro Asp Phe
Val Leu Pro 180 185 190 Leu Gly Lys Ala Lys Ile Glu Arg Glu Gly Lys
Asp Ile Thr Leu Val 195 200 205 Gly His Ser Arg Asn Val Glu Thr Ala
Leu Lys Ala Ala Asp Leu Leu 210 215 220 Lys Lys His His Asn Val Asp
Ala Glu Val Ile Asn Leu Arg Thr Val 225 230 235 240 Lys Pro Leu Asp
Thr Glu Thr Ile Phe Asn Ser Ile Lys Lys Thr Asn 245 250 255 Arg Leu
Val Ser Val Glu Ala Gly Phe Pro Ala Phe Gly Met Gly Ser 260 265 270
Glu Leu Cys Gly Val Val Asn Asp Ser Trp Ala Trp Asp Tyr Leu Asp 275
280 285 Ala Pro Ile Gln Arg Val Thr Gly Ala Glu Val Pro Thr Pro Tyr
Ala 290 295 300 Ile Glu Leu Glu Asn Phe Ala Phe Pro Thr Pro Glu Ile
Val Val Lys 305 310 315 320 Ala Ala Lys Asp Ala Leu Tyr Ile Glu Glu
325 330 671170DNAPichia stipitis 67atggctccca agttatccca gatcgcccag
acggcccgct tggccgcttc ggccactaga 60gcccacaaca tcgccaatgt gactggaaac
actaccagat ccgtagccca agctggccag 120taccaggcat tgagaatgat
ggattcgcgt gccgcttcgt cgtcggctgt aggctcaaag 180accatcaccg
tcagagacgc ccttaatgcc gggcttgccg aggagttgga caaggacgac
240gatgtcttcc tcatgggtga agaagtggcc caatacaacg gtgcctacaa
ggtgtcacgt 300ggtttgttgg atcgttttgg tgaaagacgt gtgattgata
cccctatcac tgaaatgggt 360ttcactggtt tggctgttgg agctgccctt
catggtttga agcctgtgtt ggagttcatg 420accttcaact tcgctatgca
agctatcgat caaatcgtta actctgccgc taagacctat 480tacatgtccg
gaggtaaaca accgtgtaac atcaccttcc gtggtcccaa tggtgctgct
540gccggtgtcg gtgctcaaca ttcgcaatgt tacgctgcat ggtatggatc
tattcctggt 600ttgaaggttg tttcgcccta ctctgccgag gactacaagg
gtttgatcaa ggctgccatc 660agagacccta acccagttgt gtttttggaa
aacgaaatcg cctacggtga aaccttcgat 720atctccgagg aagctctctc
cacagacttt gttttgccta tcggcaaggc caatgtcgaa 780agagaaggaa
ctgacttgac atttgtatcg cattccagat ctgtcaagtt ctgtatggaa
840gccgctgaaa ccttggagaa ggaatacggc gtcaaggccg aagtcatcaa
cttgagatcc 900atcaagcctt tggatgttcc taccattgtt gagtcagtca
agaagactaa ccacttggtc 960actgttgaag ccggattccc agcctttggt
gttggttctg aaatctgtgc ccagatcatg 1020gaatccgagg cttttgatta
cttggatgct ccagtcgaaa gagtcactgg ttgcgaagtt 1080ccaactccat
atgctaagga attggaagac tttgctttcc cagacgaacc taccgtaatc
1140agagccgcca aaaaggtgtt atctttgtaa 117068389PRTPichia stipitis
68Met Ala Pro Lys Leu Ser Gln Ile Ala Gln Thr Ala Arg Leu Ala Ala 1
5 10 15 Ser Ala Thr Arg Ala His Asn Ile Ala Asn Val Thr Gly Asn Thr
Thr 20 25 30 Arg Ser Val Ala Gln Ala Gly Gln Tyr Gln Ala Leu Arg
Met Met Asp 35 40 45 Ser Arg Ala Ala Ser Ser Ser Ala Val Gly Ser
Lys Thr Ile Thr Val 50 55 60 Arg Asp Ala Leu Asn Ala Gly Leu Ala
Glu Glu Leu Asp Lys Asp Asp 65 70 75 80 Asp Val Phe Leu Met Gly Glu
Glu Val Ala Gln Tyr Asn Gly Ala Tyr 85 90 95 Lys Val Ser Arg Gly
Leu Leu Asp Arg Phe Gly Glu Arg Arg Val Ile 100 105 110 Asp Thr Pro
Ile Thr Glu Met Gly Phe Thr Gly Leu Ala Val Gly Ala 115 120 125 Ala
Leu His Gly Leu Lys Pro Val Leu Glu Phe Met Thr Phe Asn Phe 130 135
140 Ala Met Gln Ala Ile Asp Gln Ile Val Asn Ser Ala Ala Lys Thr Tyr
145 150 155 160 Tyr Met Ser Gly Gly Lys Gln Pro Cys Asn Ile Thr Phe
Arg Gly Pro 165 170 175 Asn Gly Ala Ala Ala Gly Val Gly Ala Gln His
Ser Gln Cys Tyr Ala 180 185 190 Ala Trp Tyr Gly Ser Ile Pro Gly Leu
Lys Val Val Ser Pro Tyr Ser 195 200 205 Ala Glu Asp Tyr Lys Gly Leu
Ile Lys Ala Ala Ile Arg Asp Pro Asn 210 215 220 Pro Val Val Phe Leu
Glu Asn Glu Ile Ala Tyr Gly Glu Thr Phe Asp 225 230 235 240 Ile Ser
Glu Glu Ala Leu Ser Thr Asp Phe Val Leu Pro Ile Gly Lys 245 250 255
Ala Asn Val Glu Arg Glu Gly Thr Asp Leu Thr Phe Val Ser His Ser 260
265 270 Arg Ser Val Lys Phe Cys Met Glu Ala Ala Glu Thr Leu Glu Lys
Glu 275 280 285 Tyr Gly Val Lys Ala Glu Val Ile Asn Leu Arg Ser Ile
Lys Pro Leu 290 295 300 Asp Val Pro Thr Ile Val Glu Ser Val Lys Lys
Thr Asn His Leu Val 305 310 315 320 Thr Val Glu Ala Gly Phe Pro Ala
Phe Gly Val Gly Ser Glu Ile Cys 325 330 335 Ala Gln Ile Met Glu Ser
Glu Ala Phe Asp Tyr Leu Asp Ala Pro Val 340 345 350 Glu Arg Val Thr
Gly Cys Glu Val Pro Thr Pro Tyr Ala Lys Glu Leu 355 360 365 Glu Asp
Phe Ala Phe Pro Asp Glu Pro Thr Val Ile Arg Ala Ala Lys 370 375 380
Lys Val Leu Ser Leu 385 691263DNASaccharomyces cerevisiae
69atgcttgctg cttcattcaa acgccaacca tcacaattgg tccgcgggtt aggagctgtt
60cttcgcactc ccaccaggat aggtcatgtt cgtaccatgg caactttaaa aacaactgat
120aagaaggccc ctgaggacat cgagggctcg gacacagtgc aaattgagtt
gcctgaatct 180tccttcgagt cgtatatgct agagcctcca gacttgtctt
atgagacttc gaaagccacc 240ttgttacaga tgtataaaga tatggtcatc
atcagaagaa tggagatggc ttgtgacgcc 300ttgtacaagg ccaagaaaat
cagaggtttt tgccatctat ctgttggtca ggaggccatt 360gctgtcggta
tcgagaatgc catcacaaaa ttggattcca tcatcacatc ttacagatgt
420cacggtttca cttttatgag aggtgcctca gtgaaagccg ttctggctga
attgatgggt 480agaagagccg gtgtctctta tggtaagggt ggttccatgc
acctttacgc tccaggcttc 540tatggtggta atggtatcgt gggtgcccag
gttcctttag gtgcaggttt agcttttgct 600caccaataca agaacgagga
cgcctgctct ttcactttgt atggtgatgg tgcctctaat 660caaggtcaag
tttttgaatc tttcaacatg gccaaattat ggaatttgcc cgtcgtgttt
720tgctgtgaga acaacaagta cggtatgggt accgccgctt caagatcctc
cgcgatgact 780gaatatttca agcgtggtca atatattcca ggtttaaaag
ttaacggtat ggatattcta 840gctgtctacc aagcatccaa gtttgctaag
gactggtgtc tatccggcaa aggtcctctc 900gttctagaat atgaaaccta
taggtacggt ggccattcta tgtctgatcc cggtactacc 960tacagaacta
gagacgagat tcagcatatg agatccaaga acgatccaat tgctggtctt
1020aagatgcatt tgattgatct aggtattgcc actgaagctg aagtcaaagc
ttacgacaag 1080tccgctagaa aatacgttga cgaacaagtt gaattagctg
atgctgctcc tcctccagaa 1140gccaaattat ccatcttgtt tgaagacgtc
tacgtgaaag gtacagaaac tccaacccta 1200agaggtagga tccctgaaga
tacttgggac ttcaaaaagc aaggttttgc ctctagggat 1260taa
126370420PRTSaccharomyces cerevisiae 70Met Leu Ala Ala Ser Phe Lys
Arg Gln Pro Ser Gln Leu Val Arg Gly 1 5 10 15 Leu Gly Ala Val Leu
Arg Thr Pro Thr Arg Ile Gly His Val Arg Thr 20 25 30 Met Ala Thr
Leu Lys Thr Thr Asp Lys Lys Ala Pro Glu Asp Ile Glu 35 40 45 Gly
Ser Asp Thr Val Gln Ile Glu Leu Pro Glu Ser Ser Phe Glu Ser 50 55
60 Tyr Met Leu Glu Pro Pro Asp Leu Ser Tyr Glu Thr Ser Lys Ala Thr
65 70 75 80 Leu Leu Gln Met Tyr Lys Asp Met Val Ile Ile Arg Arg Met
Glu Met 85 90 95 Ala Cys Asp Ala Leu Tyr Lys Ala Lys Lys Ile Arg
Gly Phe Cys His 100 105 110 Leu Ser Val Gly Gln Glu Ala Ile Ala Val
Gly Ile Glu Asn Ala Ile 115 120 125 Thr Lys Leu Asp Ser Ile Ile Thr
Ser Tyr Arg Cys His Gly Phe Thr 130 135 140 Phe Met Arg Gly Ala Ser
Val Lys Ala Val Leu Ala Glu Leu Met Gly 145 150 155 160 Arg Arg Ala
Gly Val Ser Tyr Gly Lys Gly Gly Ser Met His Leu Tyr 165 170 175 Ala
Pro Gly Phe Tyr Gly Gly Asn Gly Ile Val Gly Ala Gln Val Pro 180 185
190 Leu Gly Ala Gly Leu Ala Phe Ala His Gln Tyr Lys Asn Glu Asp Ala
195 200 205 Cys Ser Phe Thr Leu Tyr Gly Asp Gly Ala Ser Asn Gln Gly
Gln Val 210 215 220 Phe Glu Ser Phe Asn Met Ala Lys Leu Trp Asn Leu
Pro Val Val Phe 225 230 235 240 Cys Cys Glu Asn Asn Lys Tyr Gly Met
Gly Thr Ala Ala Ser Arg Ser 245 250 255 Ser Ala Met Thr Glu Tyr Phe
Lys Arg Gly Gln Tyr Ile Pro Gly Leu 260 265 270 Lys Val Asn Gly Met
Asp Ile Leu Ala Val Tyr Gln Ala Ser Lys Phe 275 280 285 Ala Lys Asp
Trp Cys Leu Ser Gly Lys Gly Pro Leu Val Leu Glu Tyr 290 295 300 Glu
Thr Tyr Arg Tyr Gly Gly His Ser Met Ser Asp Pro Gly Thr Thr 305 310
315 320 Tyr Arg Thr Arg Asp Glu Ile Gln His Met Arg Ser Lys Asn Asp
Pro 325 330 335 Ile Ala Gly Leu Lys Met His Leu Ile Asp Leu Gly Ile
Ala Thr Glu 340 345 350 Ala Glu Val Lys Ala Tyr Asp Lys Ser Ala Arg
Lys Tyr Val Asp Glu 355 360 365 Gln Val Glu Leu Ala Asp Ala Ala Pro
Pro Pro Glu Ala Lys Leu Ser 370 375 380 Ile Leu Phe Glu Asp Val Tyr
Val Lys Gly Thr Glu Thr Pro Thr Leu 385 390 395 400 Arg Gly Arg Ile
Pro Glu Asp Thr Trp Asp Phe Lys Lys Gln Gly Phe 405 410 415 Ala Ser
Arg Asp 420 711230DNASchizosaccharomyces pombe 71atgtttcgaa
cttgtacgaa gattggaaca gttcccaagg ttcttgtgaa ccaaaagggc
60ttgatcgatg
gccttcgtcg ggtcaccaca gacgcaacca cttctcgtgc caatccggct
120catgtgcctg aggaacatga caagccattt cctgttaaat tagatgatag
tgtattcgaa 180ggatacaaga tcgatgtccc ttctactgaa atcgaagtta
caaagggaga gttattgggt 240ttgtacgaga agatggtgac tattcgtcgt
ctagaacttg catgcgatgc cttgtataag 300gctaagaaga ttcgtggatt
ctgtcatctt agcattggcc aagaagctgt agctgcagga 360attgaaggtg
ctattacact tgacgacagt attatcacat cttatagatg ccacggtttt
420gcttataccc gtggtttgtc aattcgaagc attattggtg agctcatggg
acgtcaatgt 480ggtgcttcca agggcaaggg tggttctatg cacattttcg
ccaaaaactt ctatggtggt 540aatggtattg ttggtgctca aattcctttg
ggtgctggta ttggtttcgc acagaagtat 600cttgaaaaac ccactactac
ttttgctcta tatggtgatg gtgcatctaa ccaaggtcaa 660gctttcgagg
ccttcaacat ggccaaatta tggggtcttc ccgttatttt tgcttgtgaa
720aacaacaaat acggtatggg tactagtgct gaacgctctt ctgccatgac
tgagttctac 780aaacgtggac agtacattcc cggtcttttg gttaacggta
tggatgtttt ggctgttttg 840caggcttcaa agtttgctaa gaagtacact
gttgaaaact ctcaacctct gcttatggaa 900tttgtgactt atcgttatgg
tggtcactcc atgtccgatc ccggtactac ttatcgtagc 960cgtgaagaag
tgcaaaaagt acgtgctgct agagatccta ttgagggttt gaagaagcac
1020atcatggagt ggggcgtcgc taatgccaat gagcttaaaa acattgagaa
gagaatccgt 1080ggtatggttg atgaggaggt tcgtatcgct gaagaaagcc
ctttccccga tcctattgag 1140gagagtttgt tttcagatgt ttacgttgca
ggaactgaac ccgcttacgc ccgtggtaga 1200aattccctgg aatatcatca
atataagtaa 123072409PRTSchizosaccharomyces pombe 72Met Phe Arg Thr
Cys Thr Lys Ile Gly Thr Val Pro Lys Val Leu Val 1 5 10 15 Asn Gln
Lys Gly Leu Ile Asp Gly Leu Arg Arg Val Thr Thr Asp Ala 20 25 30
Thr Thr Ser Arg Ala Asn Pro Ala His Val Pro Glu Glu His Asp Lys 35
40 45 Pro Phe Pro Val Lys Leu Asp Asp Ser Val Phe Glu Gly Tyr Lys
Ile 50 55 60 Asp Val Pro Ser Thr Glu Ile Glu Val Thr Lys Gly Glu
Leu Leu Gly 65 70 75 80 Leu Tyr Glu Lys Met Val Thr Ile Arg Arg Leu
Glu Leu Ala Cys Asp 85 90 95 Ala Leu Tyr Lys Ala Lys Lys Ile Arg
Gly Phe Cys His Leu Ser Ile 100 105 110 Gly Gln Glu Ala Val Ala Ala
Gly Ile Glu Gly Ala Ile Thr Leu Asp 115 120 125 Asp Ser Ile Ile Thr
Ser Tyr Arg Cys His Gly Phe Ala Tyr Thr Arg 130 135 140 Gly Leu Ser
Ile Arg Ser Ile Ile Gly Glu Leu Met Gly Arg Gln Cys 145 150 155 160
Gly Ala Ser Lys Gly Lys Gly Gly Ser Met His Ile Phe Ala Lys Asn 165
170 175 Phe Tyr Gly Gly Asn Gly Ile Val Gly Ala Gln Ile Pro Leu Gly
Ala 180 185 190 Gly Ile Gly Phe Ala Gln Lys Tyr Leu Glu Lys Pro Thr
Thr Thr Phe 195 200 205 Ala Leu Tyr Gly Asp Gly Ala Ser Asn Gln Gly
Gln Ala Phe Glu Ala 210 215 220 Phe Asn Met Ala Lys Leu Trp Gly Leu
Pro Val Ile Phe Ala Cys Glu 225 230 235 240 Asn Asn Lys Tyr Gly Met
Gly Thr Ser Ala Glu Arg Ser Ser Ala Met 245 250 255 Thr Glu Phe Tyr
Lys Arg Gly Gln Tyr Ile Pro Gly Leu Leu Val Asn 260 265 270 Gly Met
Asp Val Leu Ala Val Leu Gln Ala Ser Lys Phe Ala Lys Lys 275 280 285
Tyr Thr Val Glu Asn Ser Gln Pro Leu Leu Met Glu Phe Val Thr Tyr 290
295 300 Arg Tyr Gly Gly His Ser Met Ser Asp Pro Gly Thr Thr Tyr Arg
Ser 305 310 315 320 Arg Glu Glu Val Gln Lys Val Arg Ala Ala Arg Asp
Pro Ile Glu Gly 325 330 335 Leu Lys Lys His Ile Met Glu Trp Gly Val
Ala Asn Ala Asn Glu Leu 340 345 350 Lys Asn Ile Glu Lys Arg Ile Arg
Gly Met Val Asp Glu Glu Val Arg 355 360 365 Ile Ala Glu Glu Ser Pro
Phe Pro Asp Pro Ile Glu Glu Ser Leu Phe 370 375 380 Ser Asp Val Tyr
Val Ala Gly Thr Glu Pro Ala Tyr Ala Arg Gly Arg 385 390 395 400 Asn
Ser Leu Glu Tyr His Gln Tyr Lys 405 731206DNACandida albicans
73atgtaccgtg caacagctac tagtcgccaa ttggtcggta ctaccgccaa tatacttgtc
60gccaaaagat caatggccaa agccgcctca gatttggtca ctatcgaatt accagccagc
120tcctacgaag gatacaattt ggaagttcca gctttgagtt ttgaaaccga
aaaagaaacc 180ttattgaaaa tgtacaaaga tatgattatc atcagaagaa
tggaaatggc agccgatgct 240ttatacaaga gtaaaaaaat tagaggtttc
tgtcacttgt ctgtcggtca agaagccatt 300gctgttggta ttgaaaatgc
cattacacca actgacactg tcattacctc ttatagatgt 360cacggttttg
cattcatgag aggtgcttct gtcaaatctg ttttggccga gttaatgggt
420agaagatctg gtattgccaa cggtaagggt ggatcaatgc atatgttcac
taacggattc 480tacggtggta acggtattgt tggtgcccaa gttccattgg
gtgctggatt ggctttctcc 540cacaagtaca agaacgacaa agctgtcact
tttgatttgt atggtgatgg tgcgtctaac 600caaggacaag ttttcgaagc
ttacaacatg gccaaattgt ggaacttacc agttattttc 660gcctgtgaaa
acaacaagta tggtatgggt acctctgctg ccagatcatc agctatgacc
720gaatactaca agagaggtca atatatccca ggtttgaaaa tcaacggtat
ggatgtgttg 780gccacctacc aagcctccaa attcgccaaa gactgggctt
ctcaaggcaa tggacctctt 840gttttagaat acgaaactta cagatatggt
ggtcactcca tgtctgatcc aggtaccact 900tacagaacca gagaagaagt
ccaacatatg agatctagaa acgatccaat tgctggattg 960aaagctgttt
tgttagaaaa agagattgct tctgaagacg aaatcaaatc ttacgacaaa
1020gccgctagaa aatacgttga tgaacaagtt gctgctgctg aagctgatgc
tccaccagaa 1080gctaaaatgg atattttatt cgaagacgtt tatgttccag
gtagtgagat tcctgttttg 1140agaggtagaa tctccgacga tagttgggat
ttcaaaaaca agactttttt gaacaaggtc 1200tattaa 120674401PRTCandida
albicans 74Met Tyr Arg Ala Thr Ala Thr Ser Arg Gln Leu Val Gly Thr
Thr Ala 1 5 10 15 Asn Ile Leu Val Ala Lys Arg Ser Met Ala Lys Ala
Ala Ser Asp Leu 20 25 30 Val Thr Ile Glu Leu Pro Ala Ser Ser Tyr
Glu Gly Tyr Asn Leu Glu 35 40 45 Val Pro Ala Leu Ser Phe Glu Thr
Glu Lys Glu Thr Leu Leu Lys Met 50 55 60 Tyr Lys Asp Met Ile Ile
Ile Arg Arg Met Glu Met Ala Ala Asp Ala 65 70 75 80 Leu Tyr Lys Ser
Lys Lys Ile Arg Gly Phe Cys His Leu Ser Val Gly 85 90 95 Gln Glu
Ala Ile Ala Val Gly Ile Glu Asn Ala Ile Thr Pro Thr Asp 100 105 110
Thr Val Ile Thr Ser Tyr Arg Cys His Gly Phe Ala Phe Met Arg Gly 115
120 125 Ala Ser Val Lys Ser Val Leu Ala Glu Leu Met Gly Arg Arg Ser
Gly 130 135 140 Ile Ala Asn Gly Lys Gly Gly Ser Met His Met Phe Thr
Asn Gly Phe 145 150 155 160 Tyr Gly Gly Asn Gly Ile Val Gly Ala Gln
Val Pro Leu Gly Ala Gly 165 170 175 Leu Ala Phe Ser His Lys Tyr Lys
Asn Asp Lys Ala Val Thr Phe Asp 180 185 190 Leu Tyr Gly Asp Gly Ala
Ser Asn Gln Gly Gln Val Phe Glu Ala Tyr 195 200 205 Asn Met Ala Lys
Leu Trp Asn Leu Pro Val Ile Phe Ala Cys Glu Asn 210 215 220 Asn Lys
Tyr Gly Met Gly Thr Ser Ala Ala Arg Ser Ser Ala Met Thr 225 230 235
240 Glu Tyr Tyr Lys Arg Gly Gln Tyr Ile Pro Gly Leu Lys Ile Asn Gly
245 250 255 Met Asp Val Leu Ala Thr Tyr Gln Ala Ser Lys Phe Ala Lys
Asp Trp 260 265 270 Ala Ser Gln Gly Asn Gly Pro Leu Val Leu Glu Tyr
Glu Thr Tyr Arg 275 280 285 Tyr Gly Gly His Ser Met Ser Asp Pro Gly
Thr Thr Tyr Arg Thr Arg 290 295 300 Glu Glu Val Gln His Met Arg Ser
Arg Asn Asp Pro Ile Ala Gly Leu 305 310 315 320 Lys Ala Val Leu Leu
Glu Lys Glu Ile Ala Ser Glu Asp Glu Ile Lys 325 330 335 Ser Tyr Asp
Lys Ala Ala Arg Lys Tyr Val Asp Glu Gln Val Ala Ala 340 345 350 Ala
Glu Ala Asp Ala Pro Pro Glu Ala Lys Met Asp Ile Leu Phe Glu 355 360
365 Asp Val Tyr Val Pro Gly Ser Glu Ile Pro Val Leu Arg Gly Arg Ile
370 375 380 Ser Asp Asp Ser Trp Asp Phe Lys Asn Lys Thr Phe Leu Asn
Lys Val 385 390 395 400 Tyr 751227DNAKluyveromyces lactis
75atgctatctt tgaaagctca atcctctgtg gttgggaagt ccagctcttt gagattggtt
60agaaactttt ctaaaaacgt ccgtgctttg tcccaggttg ctgatgaaac taagccaggt
120gatgatgacc tagttcaaat tgatttgcca gaaacctctt ttgaaggtta
tcttttggat 180gttcctgaat taagttatca aaccaccaag tccaatttgc
tacaaatgta caaggatatg 240attatcgtta gaagaatgga aatggcctgt
gacgctttgt acaaggctaa gaaaattaga 300ggtttctgtc actcctctgt
cggtcaagaa gccattgccg ttggtattga aaacgctatc 360actaagcgtg
ataccgtcat cacctcttac agatgtcatg gtttcaccta catgagaggt
420gctgctgttc aagctgtgtt ggctgaattg atgggtagaa gaactggtgt
gtccttcggt 480aagggtggtt ccatgcactt gtacgcccct ggtttctacg
gtggtaatgg tatcgttggt 540gcccaagtcc cattgggtgc tggtttggcc
ttcgctcatc aatacaaaca cgaagatgct 600tgttcttttg ccttgtacgg
tgatggtgcc tctaaccaag gtcaagtttt cgaatccttc 660aacatggcca
agttatggaa cttaccagcc gtcttctgtt gtgaaaacaa caagtacggt
720atgggtaccg ctgccgcaag atcttcagcc atgactgaat acttcaagcg
tggtcaatac 780attcctggtt tgaaggttaa cggtatggat atcttggctg
ttaccaagct taaggactgg 840actgtctccg gtaacggtcc aatcgttctt
gaatacgaaa cttacagata tggtggtcac 900tctatgtctg atccaggtac
tacttacaga accagagatg aaatccaaca catgagatct 960aagaacgatc
caattgcagg tttaaagatg cacttattgg aattgggtat cgccacggaa
1020gatgaaatta aggcttacga caaggctgct agaaagtacg tcgatgagca
agtcgaatta 1080gctgatgctg ccccagctcc agaagctaag atgtccatct
tgttcgagga tgtctacgtt 1140ccaggttctg aaactccaac cctaagaggt
agattgcaag aagatacttg ggattttgct 1200aagaagagct ttgctttcag agattag
122776408PRTKluyveromyces lactis 76Met Leu Ser Leu Lys Ala Gln Ser
Ser Val Val Gly Lys Ser Ser Ser 1 5 10 15 Leu Arg Leu Val Arg Asn
Phe Ser Lys Asn Val Arg Ala Leu Ser Gln 20 25 30 Val Ala Asp Glu
Thr Lys Pro Gly Asp Asp Asp Leu Val Gln Ile Asp 35 40 45 Leu Pro
Glu Thr Ser Phe Glu Gly Tyr Leu Leu Asp Val Pro Glu Leu 50 55 60
Ser Tyr Gln Thr Thr Lys Ser Asn Leu Leu Gln Met Tyr Lys Asp Met 65
70 75 80 Ile Ile Val Arg Arg Met Glu Met Ala Cys Asp Ala Leu Tyr
Lys Ala 85 90 95 Lys Lys Ile Arg Gly Phe Cys His Ser Ser Val Gly
Gln Glu Ala Ile 100 105 110 Ala Val Gly Ile Glu Asn Ala Ile Thr Lys
Arg Asp Thr Val Ile Thr 115 120 125 Ser Tyr Arg Cys His Gly Phe Thr
Tyr Met Arg Gly Ala Ala Val Gln 130 135 140 Ala Val Leu Ala Glu Leu
Met Gly Arg Arg Thr Gly Val Ser Phe Gly 145 150 155 160 Lys Gly Gly
Ser Met His Leu Tyr Ala Pro Gly Phe Tyr Gly Gly Asn 165 170 175 Gly
Ile Val Gly Ala Gln Val Pro Leu Gly Ala Gly Leu Ala Phe Ala 180 185
190 His Gln Tyr Lys His Glu Asp Ala Cys Ser Phe Ala Leu Tyr Gly Asp
195 200 205 Gly Ala Ser Asn Gln Gly Gln Val Phe Glu Ser Phe Asn Met
Ala Lys 210 215 220 Leu Trp Asn Leu Pro Ala Val Phe Cys Cys Glu Asn
Asn Lys Tyr Gly 225 230 235 240 Met Gly Thr Ala Ala Ala Arg Ser Ser
Ala Met Thr Glu Tyr Phe Lys 245 250 255 Arg Gly Gln Tyr Ile Pro Gly
Leu Lys Val Asn Gly Met Asp Ile Leu 260 265 270 Ala Val Thr Lys Leu
Lys Asp Trp Thr Val Ser Gly Asn Gly Pro Ile 275 280 285 Val Leu Glu
Tyr Glu Thr Tyr Arg Tyr Gly Gly His Ser Met Ser Asp 290 295 300 Pro
Gly Thr Thr Tyr Arg Thr Arg Asp Glu Ile Gln His Met Arg Ser 305 310
315 320 Lys Asn Asp Pro Ile Ala Gly Leu Lys Met His Leu Leu Glu Leu
Gly 325 330 335 Ile Ala Thr Glu Asp Glu Ile Lys Ala Tyr Asp Lys Ala
Ala Arg Lys 340 345 350 Tyr Val Asp Glu Gln Val Glu Leu Ala Asp Ala
Ala Pro Ala Pro Glu 355 360 365 Ala Lys Met Ser Ile Leu Phe Glu Asp
Val Tyr Val Pro Gly Ser Glu 370 375 380 Thr Pro Thr Leu Arg Gly Arg
Leu Gln Glu Asp Thr Trp Asp Phe Ala 385 390 395 400 Lys Lys Ser Phe
Ala Phe Arg Asp 405 771185DNAYarrowia lipolytica 77atgctcactg
ccgctcgacg atctacacgg ctcaccagcc gactcggcca ccaggtccga 60gcatactcca
tcgctgacga tgccgacaag aaatgcacaa tcacgctcaa ggaggattct
120tacaccacct acatgcttga ttctccccct cctctcgagt tcgagatgac
caagggtgag 180cttctgcaaa tgtacaagga catggtgacc gtccgacgac
tcgagatggc tgctgatgcc 240ctctacaagg ccaagaagat ccgaggtttc
tgccatctgt ctactggtca ggaggctgtt 300gccgtcggta tcgagaaggc
catcgaccac gacgattctg tcatcaccgc ctaccgatgc 360cacggtttcg
cctacatgcg aggtgcctct gtccgagcaa tcatcgccga gctgctcgga
420aagcgaaccg gtgtctccta cggtaagggt ggatccatgc acatgttcac
cgagggtttc 480tacggaggaa acggtattgt cggagcccag gtccccgtcg
gagctggtct cgccttcgcc 540cacaagtacc tcgagcagac cggaaaggcc
acctttgccc tgtacggtga cggtgcttcc 600aaccagggtc agatcttcga
ggcctacaac atggccaagc tctgggacct cccctgcatc 660tttgcatgcg
agaacaacaa gtacggaatg ggtaccgctg ctgctcgatc ctctgccctg
720acgcagtact acaagcgagg tcagtacatt cccggtctca aggttaacgg
aatggacatt 780ctgtccgtct accagggagc caagttcgcc aaggagtgga
ccacacacgg caagggtccc 840ctcgtcatgg agttcgagac ctaccgatac
ggtggtcact ccatgtccga tcccggaacc 900acctaccgaa cccgagagga
gatccagtac atgcgatccc acaacgatcc tatttctggt 960ctcaaggccc
acatcctgga gcttaatttc gccactgagg acgagcttaa gtctgtggac
1020aaggctgctc gagctatggt tgacaaggag gttgcccttg ctgagtccga
ccctgctcct 1080gaggctactg ccaaggttct gtttgaggat atctacgttc
ccggcaccga gcctcctgtg 1140atccgaggcc gaatcccttc cgaggactac
tactttaaga actaa 118578394PRTYarrowia lipolytica 78Met Leu Thr Ala
Ala Arg Arg Ser Thr Arg Leu Thr Ser Arg Leu Gly 1 5 10 15 His Gln
Val Arg Ala Tyr Ser Ile Ala Asp Asp Ala Asp Lys Lys Cys 20 25 30
Thr Ile Thr Leu Lys Glu Asp Ser Tyr Thr Thr Tyr Met Leu Asp Ser 35
40 45 Pro Pro Pro Leu Glu Phe Glu Met Thr Lys Gly Glu Leu Leu Gln
Met 50 55 60 Tyr Lys Asp Met Val Thr Val Arg Arg Leu Glu Met Ala
Ala Asp Ala 65 70 75 80 Leu Tyr Lys Ala Lys Lys Ile Arg Gly Phe Cys
His Leu Ser Thr Gly 85 90 95 Gln Glu Ala Val Ala Val Gly Ile Glu
Lys Ala Ile Asp His Asp Asp 100 105 110 Ser Val Ile Thr Ala Tyr Arg
Cys His Gly Phe Ala Tyr Met Arg Gly 115 120 125 Ala Ser Val Arg Ala
Ile Ile Ala Glu Leu Leu Gly Lys Arg Thr Gly 130 135 140 Val Ser Tyr
Gly Lys Gly Gly Ser Met His Met Phe Thr Glu Gly Phe 145 150 155 160
Tyr Gly Gly Asn Gly Ile Val Gly Ala Gln Val Pro Val Gly Ala Gly 165
170 175 Leu Ala Phe Ala His Lys Tyr Leu Glu Gln Thr Gly Lys Ala Thr
Phe 180 185 190 Ala Leu Tyr Gly Asp Gly Ala Ser Asn Gln Gly Gln Ile
Phe Glu Ala 195 200 205 Tyr Asn Met Ala Lys Leu Trp Asp Leu Pro Cys
Ile Phe Ala Cys Glu 210 215 220 Asn Asn Lys Tyr Gly Met Gly Thr Ala
Ala Ala Arg Ser Ser Ala Leu 225 230 235 240 Thr Gln Tyr Tyr Lys Arg
Gly Gln Tyr Ile Pro Gly Leu Lys Val Asn 245 250 255 Gly Met Asp Ile
Leu Ser Val Tyr Gln Gly Ala Lys Phe Ala Lys Glu 260 265 270 Trp Thr
Thr His Gly Lys Gly Pro Leu Val Met Glu Phe Glu Thr Tyr 275 280 285
Arg Tyr Gly Gly His Ser Met Ser Asp Pro Gly Thr Thr Tyr Arg Thr 290
295 300
Arg Glu Glu Ile Gln Tyr Met Arg Ser His Asn Asp Pro Ile Ser Gly 305
310 315 320 Leu Lys Ala His Ile Leu Glu Leu Asn Phe Ala Thr Glu Asp
Glu Leu 325 330 335 Lys Ser Val Asp Lys Ala Ala Arg Ala Met Val Asp
Lys Glu Val Ala 340 345 350 Leu Ala Glu Ser Asp Pro Ala Pro Glu Ala
Thr Ala Lys Val Leu Phe 355 360 365 Glu Asp Ile Tyr Val Pro Gly Thr
Glu Pro Pro Val Ile Arg Gly Arg 370 375 380 Ile Pro Ser Glu Asp Tyr
Tyr Phe Lys Asn 385 390 791191DNAPichia stipitis 79atgttacgta
ctgctgctgt tcgtcctctt aagggcggtg ttgtcatcgc cagaagagcc 60atggcctcgt
ccagcgactt ggtcagcatc gaattgcctg aatcgtcgtt tgaaggctac
120aacttggaga tccccgagtt gactttcgaa accgaaaagg aaaccttgtt
gaagatgtac 180aaggatatga tcatcatcag aagaatggaa atggcttcag
acgccttgta caaggccaag 240aagatcagag ggttctgcca cttgtctgtt
ggtcaagaag ccattgccgt tggaattgag 300aacgccatta ctcctgaaga
tactgtcatc acctcttaca gatgtcacgg ttttgctttc 360atgagaggtg
cttctgtcaa ggaagttctc ggagaattga tgggtaagag atctggtgtt
420tcttatggta aaggtggttc tatgcacatg tttgccccag gcttttacgg
aggaaacggt 480atcgttggag ctcaagttcc attgggtgct ggtttagctt
tctcccacaa gtacagggga 540cagaaggctg ctgccttcac tttgtacggt
gacggtgcct ccaaccaggg acaagttttc 600gaagcctaca acatggccaa
gttgtggaac ttgccttgta tctttgcctg tgaaaacaac 660aagtacggta
tgggtactgc tgctgccaga tcctctgcta ttactgagta ctacaagaga
720ggtcaataca ttcctggttt gaagatcaac ggtatggacg ttttggctac
ctaccaggct 780tccaagtttg ccaaggactg ggctgctcaa ggcaacggac
cattggtttt ggaatacgaa 840acctacagat acggtggtca ctccatgtct
gacccaggta ccacctacag aacaagagaa 900gaagtgcaac acatgagatc
cagaaacgat cctattgccg gcttaaaggc tactttgttg 960gacaagggca
ttgctaccga agaagaaatc aagtcctatg acaaggctgc cagaaagtac
1020gtcgacgaac aagtcgctgc tgctgaagct gacgctcctc ctgaagccaa
gatggacatc 1080ttattcgaag atgtatatgt cccaggatct gaaatcccag
tgttgagagg cagaatctcg 1140gacgactcgt gggacttcaa gaacaaaact
ttcttgaaca aggtctacta g 119180396PRTPichia stipitis 80Met Leu Arg
Thr Ala Ala Val Arg Pro Leu Lys Gly Gly Val Val Ile 1 5 10 15 Ala
Arg Arg Ala Met Ala Ser Ser Ser Asp Leu Val Ser Ile Glu Leu 20 25
30 Pro Glu Ser Ser Phe Glu Gly Tyr Asn Leu Glu Ile Pro Glu Leu Thr
35 40 45 Phe Glu Thr Glu Lys Glu Thr Leu Leu Lys Met Tyr Lys Asp
Met Ile 50 55 60 Ile Ile Arg Arg Met Glu Met Ala Ser Asp Ala Leu
Tyr Lys Ala Lys 65 70 75 80 Lys Ile Arg Gly Phe Cys His Leu Ser Val
Gly Gln Glu Ala Ile Ala 85 90 95 Val Gly Ile Glu Asn Ala Ile Thr
Pro Glu Asp Thr Val Ile Thr Ser 100 105 110 Tyr Arg Cys His Gly Phe
Ala Phe Met Arg Gly Ala Ser Val Lys Glu 115 120 125 Val Leu Gly Glu
Leu Met Gly Lys Arg Ser Gly Val Ser Tyr Gly Lys 130 135 140 Gly Gly
Ser Met His Met Phe Ala Pro Gly Phe Tyr Gly Gly Asn Gly 145 150 155
160 Ile Val Gly Ala Gln Val Pro Leu Gly Ala Gly Leu Ala Phe Ser His
165 170 175 Lys Tyr Arg Gly Gln Lys Ala Ala Ala Phe Thr Leu Tyr Gly
Asp Gly 180 185 190 Ala Ser Asn Gln Gly Gln Val Phe Glu Ala Tyr Asn
Met Ala Lys Leu 195 200 205 Trp Asn Leu Pro Cys Ile Phe Ala Cys Glu
Asn Asn Lys Tyr Gly Met 210 215 220 Gly Thr Ala Ala Ala Arg Ser Ser
Ala Ile Thr Glu Tyr Tyr Lys Arg 225 230 235 240 Gly Gln Tyr Ile Pro
Gly Leu Lys Ile Asn Gly Met Asp Val Leu Ala 245 250 255 Thr Tyr Gln
Ala Ser Lys Phe Ala Lys Asp Trp Ala Ala Gln Gly Asn 260 265 270 Gly
Pro Leu Val Leu Glu Tyr Glu Thr Tyr Arg Tyr Gly Gly His Ser 275 280
285 Met Ser Asp Pro Gly Thr Thr Tyr Arg Thr Arg Glu Glu Val Gln His
290 295 300 Met Arg Ser Arg Asn Asp Pro Ile Ala Gly Leu Lys Ala Thr
Leu Leu 305 310 315 320 Asp Lys Gly Ile Ala Thr Glu Glu Glu Ile Lys
Ser Tyr Asp Lys Ala 325 330 335 Ala Arg Lys Tyr Val Asp Glu Gln Val
Ala Ala Ala Glu Ala Asp Ala 340 345 350 Pro Pro Glu Ala Lys Met Asp
Ile Leu Phe Glu Asp Val Tyr Val Pro 355 360 365 Gly Ser Glu Ile Pro
Val Leu Arg Gly Arg Ile Ser Asp Asp Ser Trp 370 375 380 Asp Phe Lys
Asn Lys Thr Phe Leu Asn Lys Val Tyr 385 390 395 8176DNAartificial
sequenceprimer 81gtgagtgcta caagccacat ttaaactaag tcaattacac
aaagttagtg ggtcgcctga 60cgcatatacc tttttc 768276DNAartificial
sequenceprimer 82attttaccta acaagttgtt gcgtaaattt ataaagtaaa
ttgtcggttt ttttgtgtgg 60tgccctcctc cttgtc 768333DNAartificial
sequenceprimer 83gagtcatctc aaacatatgt ctgcagatac ttc
338431DNAartificial sequenceprimer 84gaaatagctt taagaacctt
aatggcttcg g 31854280DNAartificial sequencevector 85ggggatcctc
tagagtcgac ctgcaggcat gcaagcttgg cgtaatcatg gtcatagctg 60tttcctgtgt
gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata
120aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc
gttgcgctca 180ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc
attaatgaat cggccaacgc 240gcggggagag gcggtttgcg tattgggcgc
tcttccgctt cctcgctcac tgactcgctg 300cgctcggtcg ttcggctgcg
gcgagcggta tcagctcact caaaggcggt aatacggtta 360tccacagaat
caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc
420aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc
ccctgacgag 480catcacaaaa atcgacgctc aagtcagagg tggcgaaacc
cgacaggact ataaagatac 540caggcgtttc cccctggaag ctccctcgtg
cgctctcctg ttccgaccct gccgcttacc 600ggatacctgt ccgcctttct
cccttcggga agcgtggcgc tttctcatag ctcacgctgt 660aggtatctca
gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc
720gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa
cccggtaaga 780cacgacttat cgccactggc agcagccact ggtaacagga
ttagcagagc gaggtatgta 840ggcggtgcta cagagttctt gaagtggtgg
cctaactacg gctacactag aaggacagta 900tttggtatct gcgctctgct
gaagccagtt accttcggaa aaagagttgg tagctcttga 960tccggcaaac
aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg
1020cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc
tgacgctcag 1080tggaacgaaa actcacgtta agggattttg gtcatgagat
tatcaaaaag gatcttcacc 1140tagatccttt taaattaaaa atgaagtttt
aaatcaatct aaagtatata tgagtaaact 1200tggtctgaca gttaccaatg
cttaatcagt gaggcaccta tctcagcgat ctgtctattt 1260cgttcatcca
tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta
1320ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc
tccagattta 1380tcagcaataa accagccagc cggaagggcc gagcgcagaa
gtggtcctgc aactttatcc 1440gcctccatcc agtctattaa ttgttgccgg
gaagctagag taagtagttc gccagttaat 1500agtttgcgca acgttgttgc
cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt 1560atggcttcat
tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg
1620tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa
gttggccgca 1680gtgttatcac tcatggttat ggcagcactg cataattctc
ttactgtcat gccatccgta 1740agatgctttt ctgtgactgg tgagtactca
accaagtcat tctgagaata gtgtatgcgg 1800cgaccgagtt gctcttgccc
ggcgtcaata cgggataata ccgcgccaca tagcagaact 1860ttaaaagtgc
tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg
1920ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc
agcatctttt 1980actttcacca gcgtttctgg gtgagcaaaa acaggaaggc
aaaatgccgc aaaaaaggga 2040ataagggcga cacggaaatg ttgaatactc
atactcttcc tttttcaata ttattgaagc 2100atttatcagg gttattgtct
catgagcgga tacatatttg aatgtattta gaaaaataaa 2160caaatagggg
ttccgcgcac atttccccga aaagtgccac ctgacgtcta agaaaccatt
2220attatcatga cattaaccta taaaaatagg cgtatcacga ggccctttcg
tctcgcgcgt 2280ttcggtgatg acggtgaaaa cctctgacac atgcagctcc
cggagacggt cacagcttgt 2340ctgtaagcgg atgccgggag cagacaagcc
cgtcagggcg cgtcagcggg tgttggcggg 2400tgtcggggct ggcttaacta
tgcggcatca gagcagattg tactgagagt gcaccatatg 2460cggtgtgaaa
taccgcacag atgcgtaagg agaaaatacc gcatcaggcg ccattcgcca
2520ttcaggctgc gcaactgttg ggaagggcga tcggtgcggg cctcttcgct
attacgccag 2580ctggcgaaag ggggatgtgc tgcaaggcga ttaagttggg
taacgccagg gttttcccag 2640tcacgacgtt gtaaaacgac ggccagtgaa
ttcgagctcg gtacccccgg ctctgagaca 2700gtagtaggtt agtcatcgct
ctaccgacgc gcaggaaaag aaagaagcat tgcggattac 2760gtattctaat
gttcagcccg cggaacgcca gcaaatcacc acccatgcgc atgatactga
2820gtcttgtaca cgctgggctt ccagtgtact gagagtgcac cataccacag
cttttcaatt 2880caattcatca tttttttttt attctttttt ttgatttcgg
tttctttgaa atttttttga 2940ttcggtaatc tccgaacaga aggaagaacg
aaggaaggag cacagactta gattggtata 3000tatacgcata tgtagtgttg
aagaaacatg aaattgccca gtattcttaa cccaactgca 3060cagaacaaaa
acctgcagga aacgaagata aatcatgtcg aaagctacat ataaggaacg
3120tgctgctact catcctagtc ctgttgctgc caagctattt aatatcatgc
acgaaaagca 3180aacaaacttg tgtgcttcat tggatgttcg taccaccaag
gaattactgg agttagttga 3240agcattaggt cccaaaattt gtttactaaa
aacacatgtg gatatcttga ctgatttttc 3300catggagggc acagttaagc
cgctaaaggc attatccgcc aagtacaatt ttttactctt 3360cgaagacaga
aaatttgctg acattggtaa tacagtcaaa ttgcagtact ctgcgggtgt
3420atacagaata gcagaatggg cagacattac gaatgcacac ggtgtggtgg
gcccaggtat 3480tgttagcggt ttgaagcagg cggcagaaga agtaacaaag
gaacctagag gccttttgat 3540gttagcagaa ttgtcatgca agggctccct
atctactgga gaatatacta agggtactgt 3600tgacattgcg aagagcgaca
aagattttgt tatcggcttt attgctcaaa gagacatggg 3660tggaagagat
gaaggttacg attggttgat tatgacaccc ggtgtgggtt tagatgacaa
3720gggagacgca ttgggtcaac agtatagaac cgtggatgat gtggtctcta
caggatctga 3780cattattatt gttggaagag gactatttgc aaagggaagg
gatgctaagg tagagggtga 3840acgttacaga aaagcaggct gggaagcata
tttgagaaga tgcggccagc aaaactaaaa 3900aactgtatta taagtaaatg
catgtatact aaactcacaa attagagctt caatttaatt 3960atatcagtta
ttaccctatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc
4020gcatcaggaa attgtaaacg ttaatatttt gttaaaattc gcgttaaatt
tttgttaaat 4080cagctcattt tttaaccaat aggccgaaat cggcaaaatc
ttcagcccgc ggaacgccag 4140caaatcacca cccatgcgca tgatactgag
tcttgtacac gctgggcttc cagtgatgat 4200acaacgagtt agccaaggtg
agcacggatg tctaaattag aattacgttt taatatcttt 4260ttttccatat
ctagggctag 42808685DNAartificial sequenceprimer 86ccggctctga
gacagtagta ggttagtcat cgctctaccg acgcgcagga aaagaaagaa 60gcattgcgga
ttacgtattc taatg 858786DNAartificial sequenceprimer 87ctagccctag
atatggaaaa aaagatatta aaacgtaatt ctaatttaga catccgtgct 60caccttggct
aactcgttgt atcatc 868822DNAartificial sequenceprimer 88gagaagatgc
ggccagcaaa ac 228930DNAartificial sequenceprimer 89cgccaaacaa
gtttcgggtc accccacacg 309029DNAartificial sequenceprimer
90ctcaaaattc tattgtgttt gccggtacc 299185DNAartificial
sequenceprimer 91cattagaata cgtaatccgc aatgcttctt tcttttcctg
cgcgtcggta gagcgatcgg 60tgaatgtctg gccgaacact aattc
859287DNAartificial sequenceprimer 92gatgatacaa cgagttagcc
aaggtgagca cggatgtcta aattagaatt acgtttgtta 60ccgctccatt agatggtacc
attttag 879330DNAartificial sequenceprimer 93atagatcgtg gaaaactttc
actacaaagc 309461DNAartificial sequenceprimer 94gaattagtgt
tcggccagac attcaccgat cgctctaccg acgcgcagga aaagaaagaa 60g
619560DNAartificial sequenceprimer 95ctaaaatggt accatctaat
ggagcggtaa caaacgtaat tctaatttag acatccgtgc 609620DNAartificial
sequenceprimer 96cccttggggc cgctaattag 209730DNAartificial
sequenceprimer 97gcattgcgga ttacgtattc taatgttcag
309864DNAartificial sequenceprimer 98cgtcggaggg ctgtcgcccg
ctcggcggct tctaatcacc ttggctaact cgttgtatca 60tcac
64998459DNAartificial sequencevector 99ggtggagctc cagcttttgt
tccctttagt gagggttaat tgcgcgcttg gcgtaatcat 60ggtcatagct gtttcctgtg
tgaaattgtt atccgctcac aattccacac aacataggag 120ccggaagcat
aaagtgtaaa gcctggggtg cctaatgagt gaggtaactc acattaattg
180cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg
cattaatgaa 240tcggccaacg cgcggggaga ggcggtttgc gtattgggcg
ctcttccgct tcctcgctca 300ctgactcgct gcgctcggtc gttcggctgc
ggcgagcggt atcagctcac tcaaaggcgg 360taatacggtt atccacagaa
tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc 420agcaaaaggc
caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc
480cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac
ccgacaggac 540tataaagata ccaggcgttt ccccctggaa gctccctcgt
gcgctctcct gttccgaccc 600tgccgcttac cggatacctg tccgcctttc
tcccttcggg aagcgtggcg ctttctcata 660gctcacgctg taggtatctc
agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc 720acgaaccccc
cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca
780acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg
attagcagag 840cgaggtatgt aggcggtgct acagagttct tgaagtggtg
gcctaactac ggctacacta 900gaaggacagt atttggtatc tgcgctctgc
tgaagccagt taccttcgga aaaagagttg 960gtagctcttg atccggcaaa
caaaccaccg ctggtagcgg tggttttttt gtttgcaagc 1020agcagattac
gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt
1080ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga
ttatcaaaaa 1140ggatcttcac ctagatcctt ttaaattaaa aatgaagttt
taaatcaatc taaagtatat 1200atgagtaaac ttggtctgac agttaccaat
gcttaatcag tgaggcacct atctcagcga 1260tctgtctatt tcgttcatcc
atagttgcct gactccccgt cgtgtagata actacgatac 1320gggagggctt
accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg
1380ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga
agtggtcctg 1440caactttatc cgcctccatc cagtctatta attgttgccg
ggaagctaga gtaagtagtt 1500cgccagttaa tagtttgcgc aacgttgttg
ccattgctac aggcatcgtg gtgtcacgct 1560cgtcgtttgg tatggcttca
ttcagctccg gttcccaacg atcaaggcga gttacatgat 1620cccccatgtt
gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta
1680agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct
cttactgtca 1740tgccatccgt aagatgcttt tctgtgactg gtgagtactc
aaccaagtca ttctgagaat 1800agtgtatgcg gcgaccgagt tgctcttgcc
cggcgtcaat acgggataat accgcgccac 1860atagcagaac tttaaaagtg
ctcatcattg gaaaacgttc ttcggggcga aaactctcaa 1920ggatcttacc
gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt
1980cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg
caaaatgccg 2040caaaaaaggg aataagggcg acacggaaat gttgaatact
catactcttc ctttttcaat 2100attattgaag catttatcag ggttattgtc
tcatgagcgg atacatattt gaatgtattt 2160agaaaaataa acaaataggg
gttccgcgca catttccccg aaaagtgcca cctgaacgaa 2220gcatctgtgc
ttcattttgt agaacaaaaa tgcaacgcga gagcgctaat ttttcaaaca
2280aagaatctga gctgcatttt tacagaacag aaatgcaacg cgaaagcgct
attttaccaa 2340cgaagaatct gtgcttcatt tttgtaaaac aaaaatgcaa
cgcgagagcg ctaatttttc 2400aaacaaagaa tctgagctgc atttttacag
aacagaaatg caacgcgaga gcgctatttt 2460accaacaaag aatctatact
tcttttttgt tctacaaaaa tgcatcccga gagcgctatt 2520tttctaacaa
agcatcttag attacttttt ttctcctttg tgcgctctat aatgcagtct
2580cttgataact ttttgcactg taggtccgtt aaggttagaa gaaggctact
ttggtgtcta 2640ttttctcttc cataaaaaaa gcctgactcc acttcccgcg
tttactgatt actagcgaag 2700ctgcgggtgc attttttcaa gataaaggca
tccccgatta tattctatac cgatgtggat 2760tgcgcatact ttgtgaacag
aaagtgatag cgttgatgat tcttcattgg tcagaaaatt 2820atgaacggtt
tcttctattt tgtctctata tactacgtat aggaaatgtt tacattttcg
2880tattgttttc gattcactct atgaatagtt cttactacaa tttttttgtc
taaagagtaa 2940tactagagat aaacataaaa aatgtagagg tcgagtttag
atgcaagttc aaggagcgaa 3000aggtggatgg gtaggttata tagggatata
gcacagagat atatagcaaa gagatacttt 3060tgagcaatgt ttgtggaagc
ggtattcgca atattttagt agctcgttac agtccggtgc 3120gtttttggtt
ttttgaaagt gcgtcttcag agcgcttttg gttttcaaaa gcgctctgaa
3180gttcctatac tttctagaga ataggaactt cggaatagga acttcaaagc
gtttccgaaa 3240acgagcgctt ccgaaaatgc aacgcgagct gcgcacatac
agctcactgt tcacgtcgca 3300cctatatctg cgtgttgcct gtatatatat
atacatgaga agaacggcat agtgcgtgtt 3360tatgcttaaa tgcgtactta
tatgcgtcta tttatgtagg atgaaaggta gtctagtacc 3420tcctgtgata
ttatcccatt ccatgcgggg tatcgtatgc ttccttcagc actacccttt
3480agctgttcta tatgctgcca ctcctcaatt ggattagtct catccttcaa
tgctatcatt 3540tcctttgata ttggatcata ctaagaaacc attattatca
tgacattaac ctataaaaat 3600aggcgtatca cgaggccctt tcgtctcgcg
cgtttcggtg atgacggtga aaacctctga 3660cacatgcagc tcccggagac
ggtcacagct tgtctgtaag cggatgccgg gagcagacaa 3720gcccgtcagg
gcgcgtcagc gggtgttggc gggtgtcggg gctggcttaa ctatgcggca
3780tcagagcaga ttgtactgag agtgcaccat accacagctt ttcaattcaa
ttcatcattt 3840tttttttatt cttttttttg atttcggttt ctttgaaatt
tttttgattc ggtaatctcc 3900gaacagaagg aagaacgaag gaaggagcac
agacttagat tggtatatat acgcatatgt 3960agtgttgaag aaacatgaaa
ttgcccagta ttcttaaccc aactgcacag aacaaaaacc 4020tgcaggaaac
gaagataaat catgtcgaaa gctacatata aggaacgtgc tgctactcat
4080cctagtcctg ttgctgccaa gctatttaat atcatgcacg aaaagcaaac
aaacttgtgt 4140gcttcattgg atgttcgtac caccaaggaa ttactggagt
tagttgaagc attaggtccc 4200aaaatttgtt tactaaaaac acatgtggat
atcttgactg atttttccat
ggagggcaca 4260gttaagccgc taaaggcatt atccgccaag tacaattttt
tactcttcga agacagaaaa 4320tttgctgaca ttggtaatac agtcaaattg
cagtactctg cgggtgtata cagaatagca 4380gaatgggcag acattacgaa
tgcacacggt gtggtgggcc caggtattgt tagcggtttg 4440aagcaggcgg
cagaagaagt aacaaaggaa cctagaggcc ttttgatgtt agcagaattg
4500tcatgcaagg gctccctatc tactggagaa tatactaagg gtactgttga
cattgcgaag 4560agcgacaaag attttgttat cggctttatt gctcaaagag
acatgggtgg aagagatgaa 4620ggttacgatt ggttgattat gacacccggt
gtgggtttag atgacaaggg agacgcattg 4680ggtcaacagt atagaaccgt
ggatgatgtg gtctctacag gatctgacat tattattgtt 4740ggaagaggac
tatttgcaaa gggaagggat gctaaggtag agggtgaacg ttacagaaaa
4800gcaggctggg aagcatattt gagaagatgc ggccagcaaa actaaaaaac
tgtattataa 4860gtaaatgcat gtatactaaa ctcacaaatt agagcttcaa
tttaattata tcagttatta 4920ccctatgcgg tgtgaaatac cgcacagatg
cgtaaggaga aaataccgca tcaggaaatt 4980gtaaacgtta atattttgtt
aaaattcgcg ttaaattttt gttaaatcag ctcatttttt 5040aaccaatagg
ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg
5100ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga
ctccaacgtc 5160aaagggcgaa aaaccgtcta tcagggcgat ggcccactac
gtgaaccatc accctaatca 5220agttttttgg ggtcgaggtg ccgtaaagca
ctaaatcgga accctaaagg gagcccccga 5280tttagagctt gacggggaaa
gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa 5340ggagcgggcg
ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc
5400gccgcgctta atgcgccgct acagggcgcg tcgcgccatt cgccattcag
gctgcgcaac 5460tgttgggaag ggcgatcggt gcgggcctct tcgctattac
gccagctggc gaaaggggga 5520tgtgctgcaa ggcgattaag ttgggtaacg
ccagggtttt cccagtcacg acgttgtaaa 5580acgacggcca gtgagcgcgc
gtaatacgac tcactatagg gcgaattggg taccgggccc 5640cccctcgagg
tcgacggtat cgataagctt gatatcgaat tcctgcagcc cgggggatcc
5700gcatgcttgc atttagtcgt gcaatgtatg actttaagat ttgtgagcag
gaagaaaagg 5760gagaatcttc taacgataaa cccttgaaaa actgggtaga
ctacgctatg ttgagttgct 5820acgcaggctg cacaattaca cgagaatgct
cccgcctagg atttaaggct aagggacgtg 5880caatgcagac gacagatcta
aatgaccgtg tcggtgaagt gttcgccaaa cttttcggtt 5940aacacatgca
gtgatgcacg cgcgatggtg ctaagttaca tatatatata tatatatata
6000tatagccata gtgatgtcta agtaaccttt atggtatatt tcttaatgtg
gaaagatact 6060agcgcgcgca cccacacaca agcttcgtct tttcttgaag
aaaagaggaa gctcgctaaa 6120tgggattcca ctttccgttc cctgccagct
gatggaaaaa ggttagtgga acgatgaaga 6180ataaaaagag agatccactg
aggtgaaatt tcagctgaca gcgagtttca tgatcgtgat 6240gaacaatggt
aacgagttgt ggctgttgcc agggagggtg gttctcaact tttaatgtat
6300ggccaaatcg ctacttgggt ttgttatata acaaagaaga aataatgaac
tgattctctt 6360cctccttctt gtcctttctt aattctgttg taattacctt
cctttgtaat tttttttgta 6420attattcttc ttaataatcc aaacaaacac
acatattaca atagctgagg atgtatactg 6480tgggggatta cctgctggat
cgcctgcacg aactggggat tgaagaaatt ttcggtgtgc 6540caggcgatta
taacctgcag ttcctggacc agattatctc gcacaaagat atgaagtggg
6600tcggtaacgc caacgaactg aacgcgagct atatggcaga tggttatgcc
cgtaccaaaa 6660aagctgctgc gtttctgacg acctttggcg ttggcgaact
gagcgccgtc aacggactgg 6720caggaagcta cgccgagaac ctgccagttg
tcgaaattgt tgggtcgcct acttctaagg 6780ttcagaatga aggcaaattt
gtgcaccata ctctggctga tggggatttt aaacatttta 6840tgaaaatgca
tgaaccggtt actgcggccc gcacgctgct gacagcagag aatgctacgg
6900ttgagatcga ccgcgtcctg tctgcgctgc tgaaagagcg caagccggta
tatatcaatc 6960tgcctgtcga tgttgccgca gcgaaagccg aaaagccgtc
gctgccactg aaaaaagaaa 7020acagcacctc caatacatcg gaccaggaaa
ttctgaataa aatccaggaa tcactgaaga 7080atgcgaagaa accgatcgtc
atcaccggac atgagatcat ctcttttggc ctggaaaaaa 7140cggtcacgca
gttcatttct aagaccaaac tgcctatcac caccctgaac ttcggcaaat
7200ctagcgtcga tgaagcgctg ccgagttttc tgggtatcta taatggtacc
ctgtccgaac 7260cgaacctgaa agaattcgtc gaaagcgcgg actttatcct
gatgctgggc gtgaaactga 7320cggatagctc cacaggcgca tttacccacc
atctgaacga gaataaaatg atttccctga 7380atatcgacga aggcaaaatc
tttaacgagc gcatccagaa cttcgatttt gaatctctga 7440ttagttcgct
gctggatctg tccgaaattg agtataaagg taaatatatt gataaaaaac
7500aggaggattt tgtgccgtct aatgcgctgc tgagtcagga tcgtctgtgg
caagccgtag 7560aaaacctgac acagtctaat gaaacgattg ttgcggaaca
gggaacttca tttttcggcg 7620cctcatccat ttttctgaaa tccaaaagcc
atttcattgg ccaaccgctg tgggggagta 7680ttggttatac ctttccggcg
gcgctgggtt cacagattgc agataaggaa tcacgccatc 7740tgctgtttat
tggtgacggc agcctgcagc tgactgtcca ggaactgggg ctggcgatcc
7800gtgaaaaaat caatccgatt tgctttatca tcaataacga cggctacacc
gtcgaacgcg 7860aaattcatgg accgaatcaa agttacaatg acatcccgat
gtggaactat agcaaactgc 7920cggaatcctt tggcgcgaca gaggatcgcg
tggtgagtaa aattgtgcgt acggaaaacg 7980aatttgtgtc ggttatgaaa
gaagcgcagg ctgacccgaa tcgcatgtat tggattgaac 8040tgatcctggc
aaaagaaggc gcaccgaaag ttctgaaaaa gatggggaaa ctgtttgcgg
8100agcaaaataa aagctaatta attaagagta agcgaatttc ttatgattta
tgatttttat 8160tattaaataa gttataaaaa aaataagtgt atacaaattt
taaagtgact cttaggtttt 8220aaaacgaaaa ttcttattct tgagtaactc
tttcctgtag gtcaggttgc tttctcaggt 8280atagcatgag gtcgctctta
ttgaccacac ctctaccggc atgccgagca aatgcctgca 8340aatcgctccc
catttcaccc aattgtagat atgctaactc cagcaatgag ttgatgaatc
8400tcggtgtgta ttttatgtcc tcagaggaca acacctgtgg tactagttct
agagcggcc 845910064DNAartificial sequenceprimer 100gtgatgatac
aacgagttag ccaaggtgat tagaagccgc cgagcgggcg acagccctcc 60gacg
6410137DNAartificial sequenceprimer 101ttttctcctt gacgttaaag
tatagaggta tattaac 3710288DNAartificial sequenceprimer
102tgtacacacg taatcgcgcg tgtacatgtc tatatgtgtt acttgaacta
tactgttttg 60gcattgcgga ttacgtattc taatgttc 8810397DNAartificial
sequenceprimer 103aacagctcct aacccgcgga ccaattgtga tggttggcgt
ttgaatgaag cagcaagcat 60ttttctcctt gacgttaaag tatagaggta tattaac
9710430DNAartificial sequenceprimer 104gattcaggca actcaatttg
cactgtgtcc 301051449DNASaccharomyces cerevisiaeCDS(1)..(1449)
105atg tct gcc ttt gtc agg gtg gtt cca aga ata tcc aga agt tca gta
48Met Ser Ala Phe Val Arg Val Val Pro Arg Ile Ser Arg Ser Ser Val 1
5 10 15 ctc acc aga tca ttg aga ctg caa ttg aga tgc tac gca tcg tac
cca 96Leu Thr Arg Ser Leu Arg Leu Gln Leu Arg Cys Tyr Ala Ser Tyr
Pro 20 25 30 gag cac acc att att ggt atg ccg gca ctg tct cct acg
atg acg caa 144Glu His Thr Ile Ile Gly Met Pro Ala Leu Ser Pro Thr
Met Thr Gln 35 40 45 ggt aat ctt gct gct tgg act aag aag gaa ggt
gac caa ttg tct ccc 192Gly Asn Leu Ala Ala Trp Thr Lys Lys Glu Gly
Asp Gln Leu Ser Pro 50 55 60 ggt gaa gtt att gcc gaa ata gaa aca
gac aag gct caa atg gac ttt 240Gly Glu Val Ile Ala Glu Ile Glu Thr
Asp Lys Ala Gln Met Asp Phe 65 70 75 80 gag ttc caa gaa gat ggt tac
tta gcc aag att cta gtt cct gaa ggt 288Glu Phe Gln Glu Asp Gly Tyr
Leu Ala Lys Ile Leu Val Pro Glu Gly 85 90 95 aca aag gac att cct
gtc aac aag cct att gcc gtc tat gtg gag gac 336Thr Lys Asp Ile Pro
Val Asn Lys Pro Ile Ala Val Tyr Val Glu Asp 100 105 110 aaa gct gat
gtg cca gct ttt aag gac ttt aag ctg gag gat tca ggt 384Lys Ala Asp
Val Pro Ala Phe Lys Asp Phe Lys Leu Glu Asp Ser Gly 115 120 125 tct
gat tca aag acc agt acg aag gct cag cct gcc gaa cca cag gca 432Ser
Asp Ser Lys Thr Ser Thr Lys Ala Gln Pro Ala Glu Pro Gln Ala 130 135
140 gaa aag aaa caa gaa gcg cca gct gaa gag acc aag act tct gca cct
480Glu Lys Lys Gln Glu Ala Pro Ala Glu Glu Thr Lys Thr Ser Ala Pro
145 150 155 160 gaa gct aag aaa tct gac gtt gct gct cct caa ggt agg
att ttt gcc 528Glu Ala Lys Lys Ser Asp Val Ala Ala Pro Gln Gly Arg
Ile Phe Ala 165 170 175 tct cca ctt gcc aag act atc gcc ttg gaa aag
ggt att tct ttg aag 576Ser Pro Leu Ala Lys Thr Ile Ala Leu Glu Lys
Gly Ile Ser Leu Lys 180 185 190 gat gtt cac ggc act gga ccc cgc ggt
aga att acc aag gct gac att 624Asp Val His Gly Thr Gly Pro Arg Gly
Arg Ile Thr Lys Ala Asp Ile 195 200 205 gag tca tat cta gaa aag tcg
tct aag cag tct tct caa acc agt ggt 672Glu Ser Tyr Leu Glu Lys Ser
Ser Lys Gln Ser Ser Gln Thr Ser Gly 210 215 220 gct gcc gcc gcc act
cct gcc gcc gct acc tca agc act act gct ggc 720Ala Ala Ala Ala Thr
Pro Ala Ala Ala Thr Ser Ser Thr Thr Ala Gly 225 230 235 240 tct gct
cca tcg cct tct tct aca gca tca tat gag gat gtt cca att 768Ser Ala
Pro Ser Pro Ser Ser Thr Ala Ser Tyr Glu Asp Val Pro Ile 245 250 255
tca acc atg aga agc atc att gga gaa cgt tta ttg caa tct act caa
816Ser Thr Met Arg Ser Ile Ile Gly Glu Arg Leu Leu Gln Ser Thr Gln
260 265 270 ggc att cca tca tac atc gtt tcc tcc aag ata tcc atc tcc
aaa ctt 864Gly Ile Pro Ser Tyr Ile Val Ser Ser Lys Ile Ser Ile Ser
Lys Leu 275 280 285 ttg aaa ttg aga cag tcc ttg aac gct aca gca aac
gac aag tac aaa 912Leu Lys Leu Arg Gln Ser Leu Asn Ala Thr Ala Asn
Asp Lys Tyr Lys 290 295 300 ctg tcc att aat gac cta tta gta aaa gcc
atc act gtt gcg gct aag 960Leu Ser Ile Asn Asp Leu Leu Val Lys Ala
Ile Thr Val Ala Ala Lys 305 310 315 320 agg gtg cca gat gcc aat gcc
tac tgg tta cct aat gag aac gtt atc 1008Arg Val Pro Asp Ala Asn Ala
Tyr Trp Leu Pro Asn Glu Asn Val Ile 325 330 335 cgt aaa ttc aag aat
gtc gat gtc tca gtc gct gtt gcc aca cca aca 1056Arg Lys Phe Lys Asn
Val Asp Val Ser Val Ala Val Ala Thr Pro Thr 340 345 350 gga tta ttg
aca cca att gtc aag aat tgt gag gcc aag ggc ttg tcg 1104Gly Leu Leu
Thr Pro Ile Val Lys Asn Cys Glu Ala Lys Gly Leu Ser 355 360 365 caa
atc tct aac gaa atc aag gaa cta gtc aag cgt gcc aga ata aac 1152Gln
Ile Ser Asn Glu Ile Lys Glu Leu Val Lys Arg Ala Arg Ile Asn 370 375
380 aaa ttg gca cca gag gaa ttc caa ggt ggg acc att tgc ata tcc aat
1200Lys Leu Ala Pro Glu Glu Phe Gln Gly Gly Thr Ile Cys Ile Ser Asn
385 390 395 400 atg ggc atg aat aat gct gtt aac atg ttt act tcg att
atc aac cca 1248Met Gly Met Asn Asn Ala Val Asn Met Phe Thr Ser Ile
Ile Asn Pro 405 410 415 cca cag tct aca atc ttg gcc atc gct act gtt
gaa agg gtc gct gtg 1296Pro Gln Ser Thr Ile Leu Ala Ile Ala Thr Val
Glu Arg Val Ala Val 420 425 430 gaa gac gcc gct gct gag aac gga ttc
tcc ttt gat aac cag gtt acc 1344Glu Asp Ala Ala Ala Glu Asn Gly Phe
Ser Phe Asp Asn Gln Val Thr 435 440 445 ata aca ggg acc ttt gat cat
aga acc att gat ggc gcc aaa ggt gca 1392Ile Thr Gly Thr Phe Asp His
Arg Thr Ile Asp Gly Ala Lys Gly Ala 450 455 460 gaa ttc atg aag gaa
ttg aaa act gtt att gaa aat cct ttg gaa atg 1440Glu Phe Met Lys Glu
Leu Lys Thr Val Ile Glu Asn Pro Leu Glu Met 465 470 475 480 cta ttg
tga 1449Leu Leu 106482PRTSaccharomyces cerevisiae 106Met Ser Ala
Phe Val Arg Val Val Pro Arg Ile Ser Arg Ser Ser Val 1 5 10 15 Leu
Thr Arg Ser Leu Arg Leu Gln Leu Arg Cys Tyr Ala Ser Tyr Pro 20 25
30 Glu His Thr Ile Ile Gly Met Pro Ala Leu Ser Pro Thr Met Thr Gln
35 40 45 Gly Asn Leu Ala Ala Trp Thr Lys Lys Glu Gly Asp Gln Leu
Ser Pro 50 55 60 Gly Glu Val Ile Ala Glu Ile Glu Thr Asp Lys Ala
Gln Met Asp Phe 65 70 75 80 Glu Phe Gln Glu Asp Gly Tyr Leu Ala Lys
Ile Leu Val Pro Glu Gly 85 90 95 Thr Lys Asp Ile Pro Val Asn Lys
Pro Ile Ala Val Tyr Val Glu Asp 100 105 110 Lys Ala Asp Val Pro Ala
Phe Lys Asp Phe Lys Leu Glu Asp Ser Gly 115 120 125 Ser Asp Ser Lys
Thr Ser Thr Lys Ala Gln Pro Ala Glu Pro Gln Ala 130 135 140 Glu Lys
Lys Gln Glu Ala Pro Ala Glu Glu Thr Lys Thr Ser Ala Pro 145 150 155
160 Glu Ala Lys Lys Ser Asp Val Ala Ala Pro Gln Gly Arg Ile Phe Ala
165 170 175 Ser Pro Leu Ala Lys Thr Ile Ala Leu Glu Lys Gly Ile Ser
Leu Lys 180 185 190 Asp Val His Gly Thr Gly Pro Arg Gly Arg Ile Thr
Lys Ala Asp Ile 195 200 205 Glu Ser Tyr Leu Glu Lys Ser Ser Lys Gln
Ser Ser Gln Thr Ser Gly 210 215 220 Ala Ala Ala Ala Thr Pro Ala Ala
Ala Thr Ser Ser Thr Thr Ala Gly 225 230 235 240 Ser Ala Pro Ser Pro
Ser Ser Thr Ala Ser Tyr Glu Asp Val Pro Ile 245 250 255 Ser Thr Met
Arg Ser Ile Ile Gly Glu Arg Leu Leu Gln Ser Thr Gln 260 265 270 Gly
Ile Pro Ser Tyr Ile Val Ser Ser Lys Ile Ser Ile Ser Lys Leu 275 280
285 Leu Lys Leu Arg Gln Ser Leu Asn Ala Thr Ala Asn Asp Lys Tyr Lys
290 295 300 Leu Ser Ile Asn Asp Leu Leu Val Lys Ala Ile Thr Val Ala
Ala Lys 305 310 315 320 Arg Val Pro Asp Ala Asn Ala Tyr Trp Leu Pro
Asn Glu Asn Val Ile 325 330 335 Arg Lys Phe Lys Asn Val Asp Val Ser
Val Ala Val Ala Thr Pro Thr 340 345 350 Gly Leu Leu Thr Pro Ile Val
Lys Asn Cys Glu Ala Lys Gly Leu Ser 355 360 365 Gln Ile Ser Asn Glu
Ile Lys Glu Leu Val Lys Arg Ala Arg Ile Asn 370 375 380 Lys Leu Ala
Pro Glu Glu Phe Gln Gly Gly Thr Ile Cys Ile Ser Asn 385 390 395 400
Met Gly Met Asn Asn Ala Val Asn Met Phe Thr Ser Ile Ile Asn Pro 405
410 415 Pro Gln Ser Thr Ile Leu Ala Ile Ala Thr Val Glu Arg Val Ala
Val 420 425 430 Glu Asp Ala Ala Ala Glu Asn Gly Phe Ser Phe Asp Asn
Gln Val Thr 435 440 445 Ile Thr Gly Thr Phe Asp His Arg Thr Ile Asp
Gly Ala Lys Gly Ala 450 455 460 Glu Phe Met Lys Glu Leu Lys Thr Val
Ile Glu Asn Pro Leu Glu Met 465 470 475 480 Leu Leu
1071500DNASaccharomyces cerevisiaeCDS(1)..(1500) 107atg tta aga atc
aga tca ctc cta aat aat aag cgt gcc ttt tcg tcc 48Met Leu Arg Ile
Arg Ser Leu Leu Asn Asn Lys Arg Ala Phe Ser Ser 1 5 10 15 aca gtc
agg aca ttg acc att aac aag tca cat gat gta gtc atc atc 96Thr Val
Arg Thr Leu Thr Ile Asn Lys Ser His Asp Val Val Ile Ile 20 25 30
ggt ggt ggc cct gct ggt tac gtg gct gct atc aaa gct gct caa ttg
144Gly Gly Gly Pro Ala Gly Tyr Val Ala Ala Ile Lys Ala Ala Gln Leu
35 40 45 gga ttt aac act gca tgt gta gaa aaa aga ggc aaa tta ggc
ggt acc 192Gly Phe Asn Thr Ala Cys Val Glu Lys Arg Gly Lys Leu Gly
Gly Thr 50 55 60 tgt ctt aac gtt gga tgt atc ccc tcc aaa gca ctt
cta aat aat tct 240Cys Leu Asn Val Gly Cys Ile Pro Ser Lys Ala Leu
Leu Asn Asn Ser 65 70 75 80 cat tta ttc cac caa atg cat acg gaa gcg
caa aag aga ggt att gac 288His Leu Phe His Gln Met His Thr Glu Ala
Gln Lys Arg Gly Ile Asp 85 90 95 gtc aac ggt gat atc aaa att aac
gta gca aac ttc caa aag gct aag 336Val Asn Gly Asp Ile Lys Ile Asn
Val Ala Asn Phe Gln Lys Ala Lys 100 105 110 gat gac gct gtt aag caa
tta act gga ggt att gag ctt ctg ttc aag 384Asp Asp Ala Val Lys Gln
Leu Thr Gly Gly Ile Glu Leu Leu Phe Lys 115
120 125 aaa aat aag gtc acc tat tat aaa ggt aat ggt tca ttc gaa gac
gaa 432Lys Asn Lys Val Thr Tyr Tyr Lys Gly Asn Gly Ser Phe Glu Asp
Glu 130 135 140 acg aag atc aga gta act ccc gtt gat ggg ttg gaa ggc
act gtc aag 480Thr Lys Ile Arg Val Thr Pro Val Asp Gly Leu Glu Gly
Thr Val Lys 145 150 155 160 gaa gac cac ata cta gat gtt aag aac atc
ata gtc gcc acg ggc tct 528Glu Asp His Ile Leu Asp Val Lys Asn Ile
Ile Val Ala Thr Gly Ser 165 170 175 gaa gtt aca ccc ttc ccc ggt att
gaa ata gat gag gaa aaa att gtc 576Glu Val Thr Pro Phe Pro Gly Ile
Glu Ile Asp Glu Glu Lys Ile Val 180 185 190 tct tca aca ggt gct ctt
tcg tta aag gaa att ccc aaa aga tta acc 624Ser Ser Thr Gly Ala Leu
Ser Leu Lys Glu Ile Pro Lys Arg Leu Thr 195 200 205 atc att ggt gga
gga atc atc gga ttg gaa atg ggt tca gtt tac tct 672Ile Ile Gly Gly
Gly Ile Ile Gly Leu Glu Met Gly Ser Val Tyr Ser 210 215 220 aga tta
ggc tcc aag gtt act gta gta gaa ttt caa cct caa att ggt 720Arg Leu
Gly Ser Lys Val Thr Val Val Glu Phe Gln Pro Gln Ile Gly 225 230 235
240 gca tct atg gac ggc gag gtt gcc aaa gcc acc caa aag ttc ttg aaa
768Ala Ser Met Asp Gly Glu Val Ala Lys Ala Thr Gln Lys Phe Leu Lys
245 250 255 aag caa ggt ttg gac ttc aaa tta agc acc aaa gtt att tct
gca aag 816Lys Gln Gly Leu Asp Phe Lys Leu Ser Thr Lys Val Ile Ser
Ala Lys 260 265 270 aga aac gac gac aag aac gtc gtc gaa att gtt gta
gaa gat act aaa 864Arg Asn Asp Asp Lys Asn Val Val Glu Ile Val Val
Glu Asp Thr Lys 275 280 285 acg aat aag caa gaa aat ttg gaa gct gaa
gtt ttg ctg gtt gct gtt 912Thr Asn Lys Gln Glu Asn Leu Glu Ala Glu
Val Leu Leu Val Ala Val 290 295 300 ggt aga aga cct tac att gct ggc
tta ggg gct gaa aag att gga tta 960Gly Arg Arg Pro Tyr Ile Ala Gly
Leu Gly Ala Glu Lys Ile Gly Leu 305 310 315 320 gaa gta gac aaa agg
gga cgc cta gtc att gat gac caa ttt aat tcc 1008Glu Val Asp Lys Arg
Gly Arg Leu Val Ile Asp Asp Gln Phe Asn Ser 325 330 335 aag ttc cca
cac att aaa gtg gta gga gat gtt aca ttt ggt cca atg 1056Lys Phe Pro
His Ile Lys Val Val Gly Asp Val Thr Phe Gly Pro Met 340 345 350 ctg
gct cac aaa gcc gaa gag gaa ggt att gca gct gtc gaa atg ttg 1104Leu
Ala His Lys Ala Glu Glu Glu Gly Ile Ala Ala Val Glu Met Leu 355 360
365 aaa act ggt cac ggt cat gtc aac tat aac aac att cct tcg gtc atg
1152Lys Thr Gly His Gly His Val Asn Tyr Asn Asn Ile Pro Ser Val Met
370 375 380 tat tct cac cca gaa gta gca tgg gtt ggt aaa acc gaa gag
caa ttg 1200Tyr Ser His Pro Glu Val Ala Trp Val Gly Lys Thr Glu Glu
Gln Leu 385 390 395 400 aaa gaa gcc ggc att gac tat aaa att ggt aag
ttc ccc ttt gcg gcc 1248Lys Glu Ala Gly Ile Asp Tyr Lys Ile Gly Lys
Phe Pro Phe Ala Ala 405 410 415 aat tca aga gcc aag acc aac caa gac
act gaa ggt ttc gtg aag att 1296Asn Ser Arg Ala Lys Thr Asn Gln Asp
Thr Glu Gly Phe Val Lys Ile 420 425 430 ttg atc gat tcc aag acc gag
cgt att ttg ggg gct cac att atc ggt 1344Leu Ile Asp Ser Lys Thr Glu
Arg Ile Leu Gly Ala His Ile Ile Gly 435 440 445 cca aat gcc ggt gaa
atg att gct gaa gct ggc tta gcc tta gaa tat 1392Pro Asn Ala Gly Glu
Met Ile Ala Glu Ala Gly Leu Ala Leu Glu Tyr 450 455 460 ggc gct tcc
gca gaa gat gtt gct agg gtc tgc cat gct cat cct act 1440Gly Ala Ser
Ala Glu Asp Val Ala Arg Val Cys His Ala His Pro Thr 465 470 475 480
ttg tcc gaa gca ttt aag gaa gct aac atg gct gcc tat gat aaa gct
1488Leu Ser Glu Ala Phe Lys Glu Ala Asn Met Ala Ala Tyr Asp Lys Ala
485 490 495 att cat tgt tga 1500Ile His Cys 108499PRT Saccharomyces
cerevisiae 108 Met Leu Arg Ile Arg Ser Leu Leu Asn Asn Lys Arg Ala
Phe Ser Ser 1 5 10 15 Thr Val Arg Thr Leu Thr Ile Asn Lys Ser His
Asp Val Val Ile Ile 20 25 30 Gly Gly Gly Pro Ala Gly Tyr Val Ala
Ala Ile Lys Ala Ala Gln Leu 35 40 45 Gly Phe Asn Thr Ala Cys Val
Glu Lys Arg Gly Lys Leu Gly Gly Thr 50 55 60 Cys Leu Asn Val Gly
Cys Ile Pro Ser Lys Ala Leu Leu Asn Asn Ser 65 70 75 80 His Leu Phe
His Gln Met His Thr Glu Ala Gln Lys Arg Gly Ile Asp 85 90 95 Val
Asn Gly Asp Ile Lys Ile Asn Val Ala Asn Phe Gln Lys Ala Lys 100 105
110 Asp Asp Ala Val Lys Gln Leu Thr Gly Gly Ile Glu Leu Leu Phe Lys
115 120 125 Lys Asn Lys Val Thr Tyr Tyr Lys Gly Asn Gly Ser Phe Glu
Asp Glu 130 135 140 Thr Lys Ile Arg Val Thr Pro Val Asp Gly Leu Glu
Gly Thr Val Lys 145 150 155 160 Glu Asp His Ile Leu Asp Val Lys Asn
Ile Ile Val Ala Thr Gly Ser 165 170 175 Glu Val Thr Pro Phe Pro Gly
Ile Glu Ile Asp Glu Glu Lys Ile Val 180 185 190 Ser Ser Thr Gly Ala
Leu Ser Leu Lys Glu Ile Pro Lys Arg Leu Thr 195 200 205 Ile Ile Gly
Gly Gly Ile Ile Gly Leu Glu Met Gly Ser Val Tyr Ser 210 215 220 Arg
Leu Gly Ser Lys Val Thr Val Val Glu Phe Gln Pro Gln Ile Gly 225 230
235 240 Ala Ser Met Asp Gly Glu Val Ala Lys Ala Thr Gln Lys Phe Leu
Lys 245 250 255 Lys Gln Gly Leu Asp Phe Lys Leu Ser Thr Lys Val Ile
Ser Ala Lys 260 265 270 Arg Asn Asp Asp Lys Asn Val Val Glu Ile Val
Val Glu Asp Thr Lys 275 280 285 Thr Asn Lys Gln Glu Asn Leu Glu Ala
Glu Val Leu Leu Val Ala Val 290 295 300 Gly Arg Arg Pro Tyr Ile Ala
Gly Leu Gly Ala Glu Lys Ile Gly Leu 305 310 315 320 Glu Val Asp Lys
Arg Gly Arg Leu Val Ile Asp Asp Gln Phe Asn Ser 325 330 335 Lys Phe
Pro His Ile Lys Val Val Gly Asp Val Thr Phe Gly Pro Met 340 345 350
Leu Ala His Lys Ala Glu Glu Glu Gly Ile Ala Ala Val Glu Met Leu 355
360 365 Lys Thr Gly His Gly His Val Asn Tyr Asn Asn Ile Pro Ser Val
Met 370 375 380 Tyr Ser His Pro Glu Val Ala Trp Val Gly Lys Thr Glu
Glu Gln Leu 385 390 395 400 Lys Glu Ala Gly Ile Asp Tyr Lys Ile Gly
Lys Phe Pro Phe Ala Ala 405 410 415 Asn Ser Arg Ala Lys Thr Asn Gln
Asp Thr Glu Gly Phe Val Lys Ile 420 425 430 Leu Ile Asp Ser Lys Thr
Glu Arg Ile Leu Gly Ala His Ile Ile Gly 435 440 445 Pro Asn Ala Gly
Glu Met Ile Ala Glu Ala Gly Leu Ala Leu Glu Tyr 450 455 460 Gly Ala
Ser Ala Glu Asp Val Ala Arg Val Cys His Ala His Pro Thr 465 470 475
480 Leu Ser Glu Ala Phe Lys Glu Ala Asn Met Ala Ala Tyr Asp Lys Ala
485 490 495 Ile His Cys 1091233DNASaccharomyces
cerevisiaeCDS(1)..(1233) 109atg cta agt gca att tcc aaa gtc tcc act
tta aaa tca tgt aca aga 48Met Leu Ser Ala Ile Ser Lys Val Ser Thr
Leu Lys Ser Cys Thr Arg 1 5 10 15 tat tta acc aaa tgc aac tat cat
gca tca gct aaa tta ctt gct gta 96Tyr Leu Thr Lys Cys Asn Tyr His
Ala Ser Ala Lys Leu Leu Ala Val 20 25 30 aag aca ttt tca atg cct
gca atg tct cct act atg gag aaa ggg ggg 144Lys Thr Phe Ser Met Pro
Ala Met Ser Pro Thr Met Glu Lys Gly Gly 35 40 45 att gtg tct tgg
aaa tat aaa gtt ggc gaa cca ttc agc gcg ggc gat 192Ile Val Ser Trp
Lys Tyr Lys Val Gly Glu Pro Phe Ser Ala Gly Asp 50 55 60 gtg ata
tta gaa gtg gaa aca gat aaa tct caa att gat gtg gaa gca 240Val Ile
Leu Glu Val Glu Thr Asp Lys Ser Gln Ile Asp Val Glu Ala 65 70 75 80
ctg gac gat ggt aaa cta gct aag atc ctg aaa gat gaa ggc tct aaa
288Leu Asp Asp Gly Lys Leu Ala Lys Ile Leu Lys Asp Glu Gly Ser Lys
85 90 95 gat gtt gat gtt ggt gaa cct att gct tat att gct gat gtt
gat gat 336Asp Val Asp Val Gly Glu Pro Ile Ala Tyr Ile Ala Asp Val
Asp Asp 100 105 110 gat tta gct act ata aag tta ccc caa gag gcc aac
acc gca aat gcg 384Asp Leu Ala Thr Ile Lys Leu Pro Gln Glu Ala Asn
Thr Ala Asn Ala 115 120 125 aaa tct att gaa att aag aag cca tcc gca
gat agt act gaa gca aca 432Lys Ser Ile Glu Ile Lys Lys Pro Ser Ala
Asp Ser Thr Glu Ala Thr 130 135 140 caa caa cat tta aaa aaa gcc aca
gtt aca cca ata aaa acc gtt gac 480Gln Gln His Leu Lys Lys Ala Thr
Val Thr Pro Ile Lys Thr Val Asp 145 150 155 160 ggc agc caa gcc aat
ctt gaa cag acg cta tta cca tcc gtg tca tta 528Gly Ser Gln Ala Asn
Leu Glu Gln Thr Leu Leu Pro Ser Val Ser Leu 165 170 175 cta ctg gct
gag aac aat ata tcc aaa caa aag gct ttg aag gaa att 576Leu Leu Ala
Glu Asn Asn Ile Ser Lys Gln Lys Ala Leu Lys Glu Ile 180 185 190 gcg
cca tct ggt tcc aac ggt aga cta tta aag ggt gat gtg cta gca 624Ala
Pro Ser Gly Ser Asn Gly Arg Leu Leu Lys Gly Asp Val Leu Ala 195 200
205 tac cta ggg aaa ata cca caa gat tcg gtt aac aag gta aca gaa ttt
672Tyr Leu Gly Lys Ile Pro Gln Asp Ser Val Asn Lys Val Thr Glu Phe
210 215 220 atc aag aag aac gaa cgt ctc gat tta tcg aac att aaa cct
ata cag 720Ile Lys Lys Asn Glu Arg Leu Asp Leu Ser Asn Ile Lys Pro
Ile Gln 225 230 235 240 ctc aaa cca aaa ata gcc gag caa gct caa aca
aaa gct gcc gac aag 768Leu Lys Pro Lys Ile Ala Glu Gln Ala Gln Thr
Lys Ala Ala Asp Lys 245 250 255 cca aag att act cct gta gaa ttt gaa
gag caa tta gtg ttc cat gct 816Pro Lys Ile Thr Pro Val Glu Phe Glu
Glu Gln Leu Val Phe His Ala 260 265 270 ccc gcc tct att ccg ttt gac
aaa ctg agt gaa tca ttg aac tct ttc 864Pro Ala Ser Ile Pro Phe Asp
Lys Leu Ser Glu Ser Leu Asn Ser Phe 275 280 285 atg aaa gaa gct tac
cag ttc tca cac gga aca cca cta atg gac aca 912Met Lys Glu Ala Tyr
Gln Phe Ser His Gly Thr Pro Leu Met Asp Thr 290 295 300 aat tcg aaa
tac ttt gac cct att ttc gag gac ctt gtc acc ttg agc 960Asn Ser Lys
Tyr Phe Asp Pro Ile Phe Glu Asp Leu Val Thr Leu Ser 305 310 315 320
cca aga gag cca aga ttt aaa ttt tcc tat gac ttg atg caa att ccc
1008Pro Arg Glu Pro Arg Phe Lys Phe Ser Tyr Asp Leu Met Gln Ile Pro
325 330 335 aaa gct aat aac atg caa gac acg tac ggt caa gaa gac ata
ttt gac 1056Lys Ala Asn Asn Met Gln Asp Thr Tyr Gly Gln Glu Asp Ile
Phe Asp 340 345 350 ctc tta aca ggt tca gac gcg act gcc tca tca gta
aga ccc gtt gaa 1104Leu Leu Thr Gly Ser Asp Ala Thr Ala Ser Ser Val
Arg Pro Val Glu 355 360 365 aag aac tta cct gaa aaa aac gaa tat ata
cta gcg ttg aat gtt agc 1152Lys Asn Leu Pro Glu Lys Asn Glu Tyr Ile
Leu Ala Leu Asn Val Ser 370 375 380 gtc aac aac aag aag ttt aat gac
gcg gag gcc aag gca aaa aga ttc 1200Val Asn Asn Lys Lys Phe Asn Asp
Ala Glu Ala Lys Ala Lys Arg Phe 385 390 395 400 ctt gat tac gta agg
gag tta gaa tca ttt tga 1233Leu Asp Tyr Val Arg Glu Leu Glu Ser Phe
405 410 110410PRTSaccharomyces cerevisiae 110Met Leu Ser Ala Ile
Ser Lys Val Ser Thr Leu Lys Ser Cys Thr Arg 1 5 10 15 Tyr Leu Thr
Lys Cys Asn Tyr His Ala Ser Ala Lys Leu Leu Ala Val 20 25 30 Lys
Thr Phe Ser Met Pro Ala Met Ser Pro Thr Met Glu Lys Gly Gly 35 40
45 Ile Val Ser Trp Lys Tyr Lys Val Gly Glu Pro Phe Ser Ala Gly Asp
50 55 60 Val Ile Leu Glu Val Glu Thr Asp Lys Ser Gln Ile Asp Val
Glu Ala 65 70 75 80 Leu Asp Asp Gly Lys Leu Ala Lys Ile Leu Lys Asp
Glu Gly Ser Lys 85 90 95 Asp Val Asp Val Gly Glu Pro Ile Ala Tyr
Ile Ala Asp Val Asp Asp 100 105 110 Asp Leu Ala Thr Ile Lys Leu Pro
Gln Glu Ala Asn Thr Ala Asn Ala 115 120 125 Lys Ser Ile Glu Ile Lys
Lys Pro Ser Ala Asp Ser Thr Glu Ala Thr 130 135 140 Gln Gln His Leu
Lys Lys Ala Thr Val Thr Pro Ile Lys Thr Val Asp 145 150 155 160 Gly
Ser Gln Ala Asn Leu Glu Gln Thr Leu Leu Pro Ser Val Ser Leu 165 170
175 Leu Leu Ala Glu Asn Asn Ile Ser Lys Gln Lys Ala Leu Lys Glu Ile
180 185 190 Ala Pro Ser Gly Ser Asn Gly Arg Leu Leu Lys Gly Asp Val
Leu Ala 195 200 205 Tyr Leu Gly Lys Ile Pro Gln Asp Ser Val Asn Lys
Val Thr Glu Phe 210 215 220 Ile Lys Lys Asn Glu Arg Leu Asp Leu Ser
Asn Ile Lys Pro Ile Gln 225 230 235 240 Leu Lys Pro Lys Ile Ala Glu
Gln Ala Gln Thr Lys Ala Ala Asp Lys 245 250 255 Pro Lys Ile Thr Pro
Val Glu Phe Glu Glu Gln Leu Val Phe His Ala 260 265 270 Pro Ala Ser
Ile Pro Phe Asp Lys Leu Ser Glu Ser Leu Asn Ser Phe 275 280 285 Met
Lys Glu Ala Tyr Gln Phe Ser His Gly Thr Pro Leu Met Asp Thr 290 295
300 Asn Ser Lys Tyr Phe Asp Pro Ile Phe Glu Asp Leu Val Thr Leu Ser
305 310 315 320 Pro Arg Glu Pro Arg Phe Lys Phe Ser Tyr Asp Leu Met
Gln Ile Pro 325 330 335 Lys Ala Asn Asn Met Gln Asp Thr Tyr Gly Gln
Glu Asp Ile Phe Asp 340 345 350 Leu Leu Thr Gly Ser Asp Ala Thr Ala
Ser Ser Val Arg Pro Val Glu 355 360 365 Lys Asn Leu Pro Glu Lys Asn
Glu Tyr Ile Leu Ala Leu Asn Val Ser 370 375 380 Val Asn Asn Lys Lys
Phe Asn Asp Ala Glu Ala Lys Ala Lys Arg Phe 385 390 395 400 Leu Asp
Tyr Val Arg Glu Leu Glu Ser Phe 405 410 1111692DNASaccharomyces
cerevisiaeCDS(1)..(1692) 111atg tct gaa att act ttg ggt aaa tat ttg
ttc gaa aga tta aag caa 48Met Ser Glu Ile Thr Leu Gly Lys Tyr Leu
Phe Glu Arg Leu Lys Gln 1 5 10 15 gtc aac gtt aac acc gtt ttc ggt
ttg cca ggt gac ttc aac ttg tcc 96Val Asn Val Asn Thr Val Phe Gly
Leu Pro Gly Asp Phe Asn Leu Ser 20 25 30 ttg ttg gac aag atc tac
gaa gtt gaa ggt atg aga tgg gct ggt aac 144Leu Leu Asp Lys Ile Tyr
Glu Val Glu Gly Met Arg Trp Ala Gly Asn 35 40 45 gcc aac gaa ttg
aac gct gct tac gcc gct gat ggt tac gct cgt atc 192Ala Asn Glu Leu
Asn Ala Ala Tyr Ala Ala Asp Gly Tyr Ala Arg Ile 50 55 60 aag ggt
atg tct tgt atc atc acc acc ttc ggt gtc ggt gaa ttg tct 240Lys Gly
Met Ser Cys Ile Ile Thr Thr Phe Gly Val Gly Glu Leu Ser 65 70 75 80
gct ttg aac ggt att gcc ggt tct tac gct gaa cac gtc ggt gtt ttg
288Ala Leu Asn Gly Ile Ala Gly Ser Tyr Ala Glu His Val Gly Val Leu
85 90 95 cac gtt gtt ggt gtc cca tcc atc tct gct caa gct aag caa
ttg ttg 336His Val Val Gly Val Pro Ser Ile Ser Ala Gln Ala Lys Gln
Leu Leu 100 105 110 ttg cac cac acc ttg ggt aac ggt gac ttc act gtt
ttc cac aga atg 384Leu His His Thr Leu Gly Asn Gly Asp Phe Thr Val
Phe His Arg Met 115 120 125 tct gcc aac att tct gaa acc act gct atg
atc act gac att gct acc 432Ser Ala Asn Ile Ser Glu Thr Thr Ala Met
Ile Thr Asp Ile Ala Thr 130 135 140 gcc cca gct gaa att gac aga tgt
atc aga acc act tac gtc acc caa 480Ala Pro Ala Glu Ile Asp Arg Cys
Ile Arg Thr Thr Tyr Val Thr Gln 145 150 155 160 aga cca gtc tac tta
ggt ttg cca gct aac ttg gtc gac ttg aac gtc 528Arg Pro Val Tyr Leu
Gly Leu Pro Ala Asn Leu Val Asp Leu Asn Val 165 170 175 cca gct aag
ttg ttg caa act cca att gac atg tct ttg aag cca aac 576Pro Ala Lys
Leu Leu Gln Thr Pro Ile Asp Met Ser Leu Lys Pro Asn 180 185 190 gat
gct gaa tcc gaa aag gaa gtc att gac acc atc ttg gct ttg gtc 624Asp
Ala Glu Ser Glu Lys Glu Val Ile Asp Thr Ile Leu Ala Leu Val 195 200
205 aag gat gct aag aac cca gtt atc ttg gct gat gct tgt tgt tcc aga
672Lys Asp Ala Lys Asn Pro Val Ile Leu Ala Asp Ala Cys Cys Ser Arg
210 215 220 cac gac gtc aag gct gaa act aag aag ttg att gac ttg act
caa ttc 720His Asp Val Lys Ala Glu Thr Lys Lys Leu Ile Asp Leu Thr
Gln Phe 225 230 235 240 cca gct ttc gtc acc cca atg ggt aag ggt tcc
att gac gaa caa cac 768Pro Ala Phe Val Thr Pro Met Gly Lys Gly Ser
Ile Asp Glu Gln His 245 250 255 cca aga tac ggt ggt gtt tac gtc ggt
acc ttg tcc aag cca gaa gtt 816Pro Arg Tyr Gly Gly Val Tyr Val Gly
Thr Leu Ser Lys Pro Glu Val 260 265 270 aag gaa gcc gtt gaa tct gct
gac ttg att ttg tct gtc ggt gct ttg 864Lys Glu Ala Val Glu Ser Ala
Asp Leu Ile Leu Ser Val Gly Ala Leu 275 280 285 ttg tct gat ttc aac
acc ggt tct ttc tct tac tct tac aag acc aag 912Leu Ser Asp Phe Asn
Thr Gly Ser Phe Ser Tyr Ser Tyr Lys Thr Lys 290 295 300 aac att gtc
gaa ttc cac tcc gac cac atg aag atc aga aac gcc act 960Asn Ile Val
Glu Phe His Ser Asp His Met Lys Ile Arg Asn Ala Thr 305 310 315 320
ttc cca ggt gtc caa atg aaa ttc gtt ttg caa aag ttg ttg acc act
1008Phe Pro Gly Val Gln Met Lys Phe Val Leu Gln Lys Leu Leu Thr Thr
325 330 335 att gct gac gcc gct aag ggt tac aag cca gtt gct gtc cca
gct aga 1056Ile Ala Asp Ala Ala Lys Gly Tyr Lys Pro Val Ala Val Pro
Ala Arg 340 345 350 act cca gct aac gct gct gtc cca gct tct acc cca
ttg aag caa gaa 1104Thr Pro Ala Asn Ala Ala Val Pro Ala Ser Thr Pro
Leu Lys Gln Glu 355 360 365 tgg atg tgg aac caa ttg ggt aac ttc ttg
caa gaa ggt gat gtt gtc 1152Trp Met Trp Asn Gln Leu Gly Asn Phe Leu
Gln Glu Gly Asp Val Val 370 375 380 att gct gaa acc ggt acc tcc gct
ttc ggt atc aac caa acc act ttc 1200Ile Ala Glu Thr Gly Thr Ser Ala
Phe Gly Ile Asn Gln Thr Thr Phe 385 390 395 400 cca aac aac acc tac
ggt atc tct caa gtc tta tgg ggt tcc att ggt 1248Pro Asn Asn Thr Tyr
Gly Ile Ser Gln Val Leu Trp Gly Ser Ile Gly 405 410 415 ttc acc act
ggt gct acc ttg ggt gct gct ttc gct gct gaa gaa att 1296Phe Thr Thr
Gly Ala Thr Leu Gly Ala Ala Phe Ala Ala Glu Glu Ile 420 425 430 gat
cca aag aag aga gtt atc tta ttc att ggt gac ggt tct ttg caa 1344Asp
Pro Lys Lys Arg Val Ile Leu Phe Ile Gly Asp Gly Ser Leu Gln 435 440
445 ttg act gtt caa gaa atc tcc acc atg atc aga tgg ggc ttg aag cca
1392Leu Thr Val Gln Glu Ile Ser Thr Met Ile Arg Trp Gly Leu Lys Pro
450 455 460 tac ttg ttc gtc ttg aac aac gat ggt tac acc att gaa aag
ttg att 1440Tyr Leu Phe Val Leu Asn Asn Asp Gly Tyr Thr Ile Glu Lys
Leu Ile 465 470 475 480 cac ggt cca aag gct caa tac aac gaa att caa
ggt tgg gac cac cta 1488His Gly Pro Lys Ala Gln Tyr Asn Glu Ile Gln
Gly Trp Asp His Leu 485 490 495 tcc ttg ttg cca act ttc ggt gct aag
gac tat gaa acc cac aga gtc 1536Ser Leu Leu Pro Thr Phe Gly Ala Lys
Asp Tyr Glu Thr His Arg Val 500 505 510 gct acc acc ggt gaa tgg gac
aag ttg acc caa gac aag tct ttc aac 1584Ala Thr Thr Gly Glu Trp Asp
Lys Leu Thr Gln Asp Lys Ser Phe Asn 515 520 525 gac aac tct aag atc
aga atg att gaa atc atg ttg cca gtc ttc gat 1632Asp Asn Ser Lys Ile
Arg Met Ile Glu Ile Met Leu Pro Val Phe Asp 530 535 540 gct cca caa
aac ttg gtt gaa caa gct aag ttg act gct gct acc aac 1680Ala Pro Gln
Asn Leu Val Glu Gln Ala Lys Leu Thr Ala Ala Thr Asn 545 550 555 560
gct aag caa taa 1692Ala Lys Gln 112563PRTSaccharomyces cerevisiae
112Met Ser Glu Ile Thr Leu Gly Lys Tyr Leu Phe Glu Arg Leu Lys Gln
1 5 10 15 Val Asn Val Asn Thr Val Phe Gly Leu Pro Gly Asp Phe Asn
Leu Ser 20 25 30 Leu Leu Asp Lys Ile Tyr Glu Val Glu Gly Met Arg
Trp Ala Gly Asn 35 40 45 Ala Asn Glu Leu Asn Ala Ala Tyr Ala Ala
Asp Gly Tyr Ala Arg Ile 50 55 60 Lys Gly Met Ser Cys Ile Ile Thr
Thr Phe Gly Val Gly Glu Leu Ser 65 70 75 80 Ala Leu Asn Gly Ile Ala
Gly Ser Tyr Ala Glu His Val Gly Val Leu 85 90 95 His Val Val Gly
Val Pro Ser Ile Ser Ala Gln Ala Lys Gln Leu Leu 100 105 110 Leu His
His Thr Leu Gly Asn Gly Asp Phe Thr Val Phe His Arg Met 115 120 125
Ser Ala Asn Ile Ser Glu Thr Thr Ala Met Ile Thr Asp Ile Ala Thr 130
135 140 Ala Pro Ala Glu Ile Asp Arg Cys Ile Arg Thr Thr Tyr Val Thr
Gln 145 150 155 160 Arg Pro Val Tyr Leu Gly Leu Pro Ala Asn Leu Val
Asp Leu Asn Val 165 170 175 Pro Ala Lys Leu Leu Gln Thr Pro Ile Asp
Met Ser Leu Lys Pro Asn 180 185 190 Asp Ala Glu Ser Glu Lys Glu Val
Ile Asp Thr Ile Leu Ala Leu Val 195 200 205 Lys Asp Ala Lys Asn Pro
Val Ile Leu Ala Asp Ala Cys Cys Ser Arg 210 215 220 His Asp Val Lys
Ala Glu Thr Lys Lys Leu Ile Asp Leu Thr Gln Phe 225 230 235 240 Pro
Ala Phe Val Thr Pro Met Gly Lys Gly Ser Ile Asp Glu Gln His 245 250
255 Pro Arg Tyr Gly Gly Val Tyr Val Gly Thr Leu Ser Lys Pro Glu Val
260 265 270 Lys Glu Ala Val Glu Ser Ala Asp Leu Ile Leu Ser Val Gly
Ala Leu 275 280 285 Leu Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr Ser
Tyr Lys Thr Lys 290 295 300 Asn Ile Val Glu Phe His Ser Asp His Met
Lys Ile Arg Asn Ala Thr 305 310 315 320 Phe Pro Gly Val Gln Met Lys
Phe Val Leu Gln Lys Leu Leu Thr Thr 325 330 335 Ile Ala Asp Ala Ala
Lys Gly Tyr Lys Pro Val Ala Val Pro Ala Arg 340 345 350 Thr Pro Ala
Asn Ala Ala Val Pro Ala Ser Thr Pro Leu Lys Gln Glu 355 360 365 Trp
Met Trp Asn Gln Leu Gly Asn Phe Leu Gln Glu Gly Asp Val Val 370 375
380 Ile Ala Glu Thr Gly Thr Ser Ala Phe Gly Ile Asn Gln Thr Thr Phe
385 390 395 400 Pro Asn Asn Thr Tyr Gly Ile Ser Gln Val Leu Trp Gly
Ser Ile Gly 405 410 415 Phe Thr Thr Gly Ala Thr Leu Gly Ala Ala Phe
Ala Ala Glu Glu Ile 420 425 430 Asp Pro Lys Lys Arg Val Ile Leu Phe
Ile Gly Asp Gly Ser Leu Gln 435 440 445 Leu Thr Val Gln Glu Ile Ser
Thr Met Ile Arg Trp Gly Leu Lys Pro 450 455 460 Tyr Leu Phe Val Leu
Asn Asn Asp Gly Tyr Thr Ile Glu Lys Leu Ile 465 470 475 480 His Gly
Pro Lys Ala Gln Tyr Asn Glu Ile Gln Gly Trp Asp His Leu 485 490 495
Ser Leu Leu Pro Thr Phe Gly Ala Lys Asp Tyr Glu Thr His Arg Val 500
505 510 Ala Thr Thr Gly Glu Trp Asp Lys Leu Thr Gln Asp Lys Ser Phe
Asn 515 520 525 Asp Asn Ser Lys Ile Arg Met Ile Glu Ile Met Leu Pro
Val Phe Asp 530 535 540 Ala Pro Gln Asn Leu Val Glu Gln Ala Lys Leu
Thr Ala Ala Thr Asn 545 550 555 560 Ala Lys Gln
1131692DNASaccharomyces cerevisiaeeCDS(1)..(1692) 113atg tct gaa
ata acc tta ggt aaa tat tta ttt gaa aga ttg agc caa 48Met Ser Glu
Ile Thr Leu Gly Lys Tyr Leu Phe Glu Arg Leu Ser Gln 1 5 10 15 gtc
aac tgt aac acc gtc ttc ggt ttg cca ggt gac ttt aac ttg tct 96Val
Asn Cys Asn Thr Val Phe Gly Leu Pro Gly Asp Phe Asn Leu Ser 20 25
30 ctt ttg gat aag ctt tat gaa gtc aaa ggt atg aga tgg gct ggt aac
144Leu Leu Asp Lys Leu Tyr Glu Val Lys Gly Met Arg Trp Ala Gly Asn
35 40 45 gct aac gaa ttg aac gct gcc tat gct gct gat ggt tac gct
cgt atc 192Ala Asn Glu Leu Asn Ala Ala Tyr Ala Ala Asp Gly Tyr Ala
Arg Ile 50 55 60 aag ggt atg tcc tgt att att acc acc ttc ggt gtt
ggt gaa ttg tct 240Lys Gly Met Ser Cys Ile Ile Thr Thr Phe Gly Val
Gly Glu Leu Ser 65 70 75 80 gct ttg aat ggt att gcc ggt tct tac gct
gaa cat gtc ggt gtt ttg 288Ala Leu Asn Gly Ile Ala Gly Ser Tyr Ala
Glu His Val Gly Val Leu 85 90 95 cac gtt gtt ggt gtt cca tcc atc
tct tct caa gct aag caa ttg ttg 336His Val Val Gly Val Pro Ser Ile
Ser Ser Gln Ala Lys Gln Leu Leu 100 105 110 ttg cat cat acc ttg ggt
aac ggt gac ttc act gtt ttc cac aga atg 384Leu His His Thr Leu Gly
Asn Gly Asp Phe Thr Val Phe His Arg Met 115 120 125 tct gcc aac att
tct gaa acc act gcc atg atc act gat att gct aac 432Ser Ala Asn Ile
Ser Glu Thr Thr Ala Met Ile Thr Asp Ile Ala Asn 130 135 140 gct cca
gct gaa att gac aga tgt atc aga acc acc tac act acc caa 480Ala Pro
Ala Glu Ile Asp Arg Cys Ile Arg Thr Thr Tyr Thr Thr Gln 145 150 155
160 aga cca gtc tac ttg ggt ttg cca gct aac ttg gtt gac ttg aac gtc
528Arg Pro Val Tyr Leu Gly Leu Pro Ala Asn Leu Val Asp Leu Asn Val
165 170 175 cca gcc aag tta ttg gaa act cca att gac ttg tct ttg aag
cca aac 576Pro Ala Lys Leu Leu Glu Thr Pro Ile Asp Leu Ser Leu Lys
Pro Asn 180 185 190 gac gct gaa gct gaa gct gaa gtt gtt aga act gtt
gtt gaa ttg atc 624Asp Ala Glu Ala Glu Ala Glu Val Val Arg Thr Val
Val Glu Leu Ile 195 200 205 aag gat gct aag aac cca gtt atc ttg gct
gat gct tgt gct tct aga 672Lys Asp Ala Lys Asn Pro Val Ile Leu Ala
Asp Ala Cys Ala Ser Arg 210 215 220 cat gat gtc aag gct gaa act aag
aag ttg atg gac ttg act caa ttc 720His Asp Val Lys Ala Glu Thr Lys
Lys Leu Met Asp Leu Thr Gln Phe 225 230 235 240 cca gtt tac gtc acc
cca atg ggt aag ggt gct att gac gaa caa cac 768Pro Val Tyr Val Thr
Pro Met Gly Lys Gly Ala Ile Asp Glu Gln His 245 250 255 cca aga tac
ggt ggt gtt tac gtt ggt acc ttg tct aga cca gaa gtt 816Pro Arg Tyr
Gly Gly Val Tyr Val Gly Thr Leu Ser Arg Pro Glu Val 260 265 270 aag
aag gct gta gaa tct gct gat ttg ata ttg tct atc ggt gct ttg 864Lys
Lys Ala Val Glu Ser Ala Asp Leu Ile Leu Ser Ile Gly Ala Leu 275 280
285 ttg tct gat ttc aat acc ggt tct ttc tct tac tcc tac aag acc aaa
912Leu Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr Ser Tyr Lys Thr Lys
290 295 300 aat atc gtt gaa ttc cac tct gac cac atc aag atc aga aac
gcc acc 960Asn Ile Val Glu Phe His Ser Asp His Ile Lys Ile Arg Asn
Ala Thr 305 310 315 320 ttc cca ggt gtt caa atg aaa ttt gcc ttg caa
aaa ttg ttg gat gct 1008Phe Pro Gly Val Gln Met Lys Phe Ala Leu Gln
Lys Leu Leu Asp Ala 325 330 335 att cca gaa gtc gtc aag gac tac aaa
cct gtt gct gtc cca gct aga 1056Ile Pro Glu Val Val Lys Asp Tyr Lys
Pro Val Ala Val Pro Ala Arg 340 345 350 gtt cca att acc aag tct act
cca gct aac act cca atg aag caa gaa 1104Val Pro Ile Thr Lys Ser Thr
Pro Ala Asn Thr Pro Met Lys Gln Glu 355 360 365 tgg atg tgg aac cat
ttg ggt aac ttc ttg aga gaa ggt gat att gtt 1152Trp Met Trp Asn His
Leu Gly Asn Phe Leu Arg Glu Gly Asp Ile Val 370 375 380 att gct gaa
acc ggt act tcc gcc ttc ggt att aac caa act act ttc 1200Ile Ala Glu
Thr Gly Thr Ser Ala Phe Gly Ile Asn Gln Thr Thr Phe 385 390 395 400
cca aca gat gta tac gct atc gtc caa gtc ttg tgg ggt tcc att ggt
1248Pro Thr Asp Val Tyr Ala Ile Val Gln Val Leu Trp Gly Ser Ile Gly
405 410 415 ttc aca gtc ggc gct cta ttg ggt gct act atg gcc gct gaa
gaa ctt 1296Phe Thr Val Gly Ala Leu Leu Gly Ala Thr Met Ala Ala Glu
Glu Leu 420 425 430 gat cca aag aag aga
gtt att tta ttc att ggt gac ggt tct cta caa 1344Asp Pro Lys Lys Arg
Val Ile Leu Phe Ile Gly Asp Gly Ser Leu Gln 435 440 445 ttg act gtt
caa gaa atc tct acc atg att aga tgg ggt ttg aag cca 1392Leu Thr Val
Gln Glu Ile Ser Thr Met Ile Arg Trp Gly Leu Lys Pro 450 455 460 tac
att ttt gtc ttg aat aac aac ggt tac acc att gaa aaa ttg att 1440Tyr
Ile Phe Val Leu Asn Asn Asn Gly Tyr Thr Ile Glu Lys Leu Ile 465 470
475 480 cac ggt cct cat gcc gaa tat aat gaa att caa ggt tgg gac cac
ttg 1488His Gly Pro His Ala Glu Tyr Asn Glu Ile Gln Gly Trp Asp His
Leu 485 490 495 gcc tta ttg cca act ttt ggt gct aga aac tac gaa acc
cac aga gtt 1536Ala Leu Leu Pro Thr Phe Gly Ala Arg Asn Tyr Glu Thr
His Arg Val 500 505 510 gct acc act ggt gaa tgg gaa aag ttg act caa
gac aag gac ttc caa 1584Ala Thr Thr Gly Glu Trp Glu Lys Leu Thr Gln
Asp Lys Asp Phe Gln 515 520 525 gac aac tct aag att aga atg att gaa
gtt atg ttg cca gtc ttt gat 1632Asp Asn Ser Lys Ile Arg Met Ile Glu
Val Met Leu Pro Val Phe Asp 530 535 540 gct cca caa aac ttg gtt aaa
caa gct caa ttg act gcc gct act aac 1680Ala Pro Gln Asn Leu Val Lys
Gln Ala Gln Leu Thr Ala Ala Thr Asn 545 550 555 560 gct aaa caa taa
1692Ala Lys Gln 114563PRTSaccharomyces cerevisiaee 114Met Ser Glu
Ile Thr Leu Gly Lys Tyr Leu Phe Glu Arg Leu Ser Gln 1 5 10 15 Val
Asn Cys Asn Thr Val Phe Gly Leu Pro Gly Asp Phe Asn Leu Ser 20 25
30 Leu Leu Asp Lys Leu Tyr Glu Val Lys Gly Met Arg Trp Ala Gly Asn
35 40 45 Ala Asn Glu Leu Asn Ala Ala Tyr Ala Ala Asp Gly Tyr Ala
Arg Ile 50 55 60 Lys Gly Met Ser Cys Ile Ile Thr Thr Phe Gly Val
Gly Glu Leu Ser 65 70 75 80 Ala Leu Asn Gly Ile Ala Gly Ser Tyr Ala
Glu His Val Gly Val Leu 85 90 95 His Val Val Gly Val Pro Ser Ile
Ser Ser Gln Ala Lys Gln Leu Leu 100 105 110 Leu His His Thr Leu Gly
Asn Gly Asp Phe Thr Val Phe His Arg Met 115 120 125 Ser Ala Asn Ile
Ser Glu Thr Thr Ala Met Ile Thr Asp Ile Ala Asn 130 135 140 Ala Pro
Ala Glu Ile Asp Arg Cys Ile Arg Thr Thr Tyr Thr Thr Gln 145 150 155
160 Arg Pro Val Tyr Leu Gly Leu Pro Ala Asn Leu Val Asp Leu Asn Val
165 170 175 Pro Ala Lys Leu Leu Glu Thr Pro Ile Asp Leu Ser Leu Lys
Pro Asn 180 185 190 Asp Ala Glu Ala Glu Ala Glu Val Val Arg Thr Val
Val Glu Leu Ile 195 200 205 Lys Asp Ala Lys Asn Pro Val Ile Leu Ala
Asp Ala Cys Ala Ser Arg 210 215 220 His Asp Val Lys Ala Glu Thr Lys
Lys Leu Met Asp Leu Thr Gln Phe 225 230 235 240 Pro Val Tyr Val Thr
Pro Met Gly Lys Gly Ala Ile Asp Glu Gln His 245 250 255 Pro Arg Tyr
Gly Gly Val Tyr Val Gly Thr Leu Ser Arg Pro Glu Val 260 265 270 Lys
Lys Ala Val Glu Ser Ala Asp Leu Ile Leu Ser Ile Gly Ala Leu 275 280
285 Leu Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr Ser Tyr Lys Thr Lys
290 295 300 Asn Ile Val Glu Phe His Ser Asp His Ile Lys Ile Arg Asn
Ala Thr 305 310 315 320 Phe Pro Gly Val Gln Met Lys Phe Ala Leu Gln
Lys Leu Leu Asp Ala 325 330 335 Ile Pro Glu Val Val Lys Asp Tyr Lys
Pro Val Ala Val Pro Ala Arg 340 345 350 Val Pro Ile Thr Lys Ser Thr
Pro Ala Asn Thr Pro Met Lys Gln Glu 355 360 365 Trp Met Trp Asn His
Leu Gly Asn Phe Leu Arg Glu Gly Asp Ile Val 370 375 380 Ile Ala Glu
Thr Gly Thr Ser Ala Phe Gly Ile Asn Gln Thr Thr Phe 385 390 395 400
Pro Thr Asp Val Tyr Ala Ile Val Gln Val Leu Trp Gly Ser Ile Gly 405
410 415 Phe Thr Val Gly Ala Leu Leu Gly Ala Thr Met Ala Ala Glu Glu
Leu 420 425 430 Asp Pro Lys Lys Arg Val Ile Leu Phe Ile Gly Asp Gly
Ser Leu Gln 435 440 445 Leu Thr Val Gln Glu Ile Ser Thr Met Ile Arg
Trp Gly Leu Lys Pro 450 455 460 Tyr Ile Phe Val Leu Asn Asn Asn Gly
Tyr Thr Ile Glu Lys Leu Ile 465 470 475 480 His Gly Pro His Ala Glu
Tyr Asn Glu Ile Gln Gly Trp Asp His Leu 485 490 495 Ala Leu Leu Pro
Thr Phe Gly Ala Arg Asn Tyr Glu Thr His Arg Val 500 505 510 Ala Thr
Thr Gly Glu Trp Glu Lys Leu Thr Gln Asp Lys Asp Phe Gln 515 520 525
Asp Asn Ser Lys Ile Arg Met Ile Glu Val Met Leu Pro Val Phe Asp 530
535 540 Ala Pro Gln Asn Leu Val Lys Gln Ala Gln Leu Thr Ala Ala Thr
Asn 545 550 555 560 Ala Lys Gln 1151599DNASaccharomyces
cerevisiaeCDS(1)..(1599) 115atg tct gaa att act ctt gga aaa tac tta
ttt gaa aga ttg aag caa 48Met Ser Glu Ile Thr Leu Gly Lys Tyr Leu
Phe Glu Arg Leu Lys Gln 1 5 10 15 gtt aat gtt aac acc att ttt ggg
cta cca ggc gac ttc aac ttg tcc 96Val Asn Val Asn Thr Ile Phe Gly
Leu Pro Gly Asp Phe Asn Leu Ser 20 25 30 cta ttg gac aag att tac
gag gta gat gga ttg aga tgg gct ggt aat 144Leu Leu Asp Lys Ile Tyr
Glu Val Asp Gly Leu Arg Trp Ala Gly Asn 35 40 45 gca aat gag ctg
aac gcc gcc tat gcc gcc gat ggt tac gca cgc atc 192Ala Asn Glu Leu
Asn Ala Ala Tyr Ala Ala Asp Gly Tyr Ala Arg Ile 50 55 60 aag ggt
tta tct gtg ctg gta act act ttt ggc gta ggt gaa tta tcc 240Lys Gly
Leu Ser Val Leu Val Thr Thr Phe Gly Val Gly Glu Leu Ser 65 70 75 80
gcc ttg aat ggt att gca gga tcg tat gca gaa cac gtc ggt gta ctg
288Ala Leu Asn Gly Ile Ala Gly Ser Tyr Ala Glu His Val Gly Val Leu
85 90 95 cat gtt gtt ggt gtc ccc tct atc tcc gct cag gct aag caa
ttg ttg 336His Val Val Gly Val Pro Ser Ile Ser Ala Gln Ala Lys Gln
Leu Leu 100 105 110 ttg cat cat acc ttg ggt aac ggt gat ttt acc gtt
ttt cac aga atg 384Leu His His Thr Leu Gly Asn Gly Asp Phe Thr Val
Phe His Arg Met 115 120 125 tcc gcc aat atc tca gaa act aca tca atg
att aca gac att gct aca 432Ser Ala Asn Ile Ser Glu Thr Thr Ser Met
Ile Thr Asp Ile Ala Thr 130 135 140 gcc cct tca gaa atc gat agg ttg
atc agg aca aca ttt ata aca caa 480Ala Pro Ser Glu Ile Asp Arg Leu
Ile Arg Thr Thr Phe Ile Thr Gln 145 150 155 160 agg cct agc tac ttg
ggg ttg cca gcg aat ttg gta gat cta aag gtt 528Arg Pro Ser Tyr Leu
Gly Leu Pro Ala Asn Leu Val Asp Leu Lys Val 165 170 175 cct ggt tct
ctt ttg gaa aaa ccg att gat cta tca tta aaa cct aac 576Pro Gly Ser
Leu Leu Glu Lys Pro Ile Asp Leu Ser Leu Lys Pro Asn 180 185 190 gat
ccc gaa gct gaa aag gaa gtt att gat acc gta cta gaa ttg atc 624Asp
Pro Glu Ala Glu Lys Glu Val Ile Asp Thr Val Leu Glu Leu Ile 195 200
205 cag aat tcg aaa aac cct gtt ata cta tcg gat gcc tgt gct tct agg
672Gln Asn Ser Lys Asn Pro Val Ile Leu Ser Asp Ala Cys Ala Ser Arg
210 215 220 cac aac gtt aaa aaa gaa acc cag aag tta att gat ttg acg
caa ttc 720His Asn Val Lys Lys Glu Thr Gln Lys Leu Ile Asp Leu Thr
Gln Phe 225 230 235 240 cca gct ttt gtg aca cct cta ggt aaa ggg tca
ata gat gaa cag cat 768Pro Ala Phe Val Thr Pro Leu Gly Lys Gly Ser
Ile Asp Glu Gln His 245 250 255 ccc aga tat ggc ggt gtt tat gtg gga
acg ctg tcc aaa caa gac gtg 816Pro Arg Tyr Gly Gly Val Tyr Val Gly
Thr Leu Ser Lys Gln Asp Val 260 265 270 aaa cag gcc gtt gag tcg gct
gat ttg atc ctt tcg gtc ggt gct ttg 864Lys Gln Ala Val Glu Ser Ala
Asp Leu Ile Leu Ser Val Gly Ala Leu 275 280 285 ctc tct gat ttt aac
aca ggt tcg ttt tcc tac tcc tac aag act aaa 912Leu Ser Asp Phe Asn
Thr Gly Ser Phe Ser Tyr Ser Tyr Lys Thr Lys 290 295 300 aat gta gtg
gag ttt cat tcc gat tac gta aag gtg aag aac gct acg 960Asn Val Val
Glu Phe His Ser Asp Tyr Val Lys Val Lys Asn Ala Thr 305 310 315 320
ttc ctc ggt gta caa atg aaa ttt gca cta caa aac tta ctg aag gtt
1008Phe Leu Gly Val Gln Met Lys Phe Ala Leu Gln Asn Leu Leu Lys Val
325 330 335 att ccc gat gtt gtt aag ggc tac aag agc gtt ccc gta cca
acc aaa 1056Ile Pro Asp Val Val Lys Gly Tyr Lys Ser Val Pro Val Pro
Thr Lys 340 345 350 act ccc gca aac aaa ggt gta cct gct agc acg ccc
ttg aaa caa gag 1104Thr Pro Ala Asn Lys Gly Val Pro Ala Ser Thr Pro
Leu Lys Gln Glu 355 360 365 tgg ttg tgg aac gaa ttg tcc aaa ttc ttg
caa gaa ggt gat gtt atc 1152Trp Leu Trp Asn Glu Leu Ser Lys Phe Leu
Gln Glu Gly Asp Val Ile 370 375 380 att tcc gag acc ggc acg tct gcc
ttc ggt atc aat caa act atc ttt 1200Ile Ser Glu Thr Gly Thr Ser Ala
Phe Gly Ile Asn Gln Thr Ile Phe 385 390 395 400 cct aag gac gcc tac
ggt atc tcg cag gtg ttg tgg ggg tcc atc ggt 1248Pro Lys Asp Ala Tyr
Gly Ile Ser Gln Val Leu Trp Gly Ser Ile Gly 405 410 415 ttt aca aca
gga gca act tta ggt gct gcc ttt gcc gct gag gag att 1296Phe Thr Thr
Gly Ala Thr Leu Gly Ala Ala Phe Ala Ala Glu Glu Ile 420 425 430 gac
ccc aac aag aga gtc atc tta ttc ata ggt gac ggg tct ttg cag 1344Asp
Pro Asn Lys Arg Val Ile Leu Phe Ile Gly Asp Gly Ser Leu Gln 435 440
445 tta acc gtc caa gaa atc tcc acc atg atc aga tgg ggg tta aag ccg
1392Leu Thr Val Gln Glu Ile Ser Thr Met Ile Arg Trp Gly Leu Lys Pro
450 455 460 tat ctt ttt gtc ctt aac aac gac ggc tac act atc gaa aag
ctg att 1440Tyr Leu Phe Val Leu Asn Asn Asp Gly Tyr Thr Ile Glu Lys
Leu Ile 465 470 475 480 cat ggg cct cac gca gag tac aac gaa atc cag
acc tgg gat cac ctc 1488His Gly Pro His Ala Glu Tyr Asn Glu Ile Gln
Thr Trp Asp His Leu 485 490 495 gcc ctg ttg ccc gca ttt ggt gcg aaa
aag tac gaa aat cac aag atc 1536Ala Leu Leu Pro Ala Phe Gly Ala Lys
Lys Tyr Glu Asn His Lys Ile 500 505 510 gcc act acg ggt gag tgg gat
gcc tta acc act gat tca gag ttc cag 1584Ala Thr Thr Gly Glu Trp Asp
Ala Leu Thr Thr Asp Ser Glu Phe Gln 515 520 525 aaa aac tcg gtg atc
1599Lys Asn Ser Val Ile 530 116533PRTSaccharomyces cerevisiae
116Met Ser Glu Ile Thr Leu Gly Lys Tyr Leu Phe Glu Arg Leu Lys Gln
1 5 10 15 Val Asn Val Asn Thr Ile Phe Gly Leu Pro Gly Asp Phe Asn
Leu Ser 20 25 30 Leu Leu Asp Lys Ile Tyr Glu Val Asp Gly Leu Arg
Trp Ala Gly Asn 35 40 45 Ala Asn Glu Leu Asn Ala Ala Tyr Ala Ala
Asp Gly Tyr Ala Arg Ile 50 55 60 Lys Gly Leu Ser Val Leu Val Thr
Thr Phe Gly Val Gly Glu Leu Ser 65 70 75 80 Ala Leu Asn Gly Ile Ala
Gly Ser Tyr Ala Glu His Val Gly Val Leu 85 90 95 His Val Val Gly
Val Pro Ser Ile Ser Ala Gln Ala Lys Gln Leu Leu 100 105 110 Leu His
His Thr Leu Gly Asn Gly Asp Phe Thr Val Phe His Arg Met 115 120 125
Ser Ala Asn Ile Ser Glu Thr Thr Ser Met Ile Thr Asp Ile Ala Thr 130
135 140 Ala Pro Ser Glu Ile Asp Arg Leu Ile Arg Thr Thr Phe Ile Thr
Gln 145 150 155 160 Arg Pro Ser Tyr Leu Gly Leu Pro Ala Asn Leu Val
Asp Leu Lys Val 165 170 175 Pro Gly Ser Leu Leu Glu Lys Pro Ile Asp
Leu Ser Leu Lys Pro Asn 180 185 190 Asp Pro Glu Ala Glu Lys Glu Val
Ile Asp Thr Val Leu Glu Leu Ile 195 200 205 Gln Asn Ser Lys Asn Pro
Val Ile Leu Ser Asp Ala Cys Ala Ser Arg 210 215 220 His Asn Val Lys
Lys Glu Thr Gln Lys Leu Ile Asp Leu Thr Gln Phe 225 230 235 240 Pro
Ala Phe Val Thr Pro Leu Gly Lys Gly Ser Ile Asp Glu Gln His 245 250
255 Pro Arg Tyr Gly Gly Val Tyr Val Gly Thr Leu Ser Lys Gln Asp Val
260 265 270 Lys Gln Ala Val Glu Ser Ala Asp Leu Ile Leu Ser Val Gly
Ala Leu 275 280 285 Leu Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr Ser
Tyr Lys Thr Lys 290 295 300 Asn Val Val Glu Phe His Ser Asp Tyr Val
Lys Val Lys Asn Ala Thr 305 310 315 320 Phe Leu Gly Val Gln Met Lys
Phe Ala Leu Gln Asn Leu Leu Lys Val 325 330 335 Ile Pro Asp Val Val
Lys Gly Tyr Lys Ser Val Pro Val Pro Thr Lys 340 345 350 Thr Pro Ala
Asn Lys Gly Val Pro Ala Ser Thr Pro Leu Lys Gln Glu 355 360 365 Trp
Leu Trp Asn Glu Leu Ser Lys Phe Leu Gln Glu Gly Asp Val Ile 370 375
380 Ile Ser Glu Thr Gly Thr Ser Ala Phe Gly Ile Asn Gln Thr Ile Phe
385 390 395 400 Pro Lys Asp Ala Tyr Gly Ile Ser Gln Val Leu Trp Gly
Ser Ile Gly 405 410 415 Phe Thr Thr Gly Ala Thr Leu Gly Ala Ala Phe
Ala Ala Glu Glu Ile 420 425 430 Asp Pro Asn Lys Arg Val Ile Leu Phe
Ile Gly Asp Gly Ser Leu Gln 435 440 445 Leu Thr Val Gln Glu Ile Ser
Thr Met Ile Arg Trp Gly Leu Lys Pro 450 455 460 Tyr Leu Phe Val Leu
Asn Asn Asp Gly Tyr Thr Ile Glu Lys Leu Ile 465 470 475 480 His Gly
Pro His Ala Glu Tyr Asn Glu Ile Gln Thr Trp Asp His Leu 485 490 495
Ala Leu Leu Pro Ala Phe Gly Ala Lys Lys Tyr Glu Asn His Lys Ile 500
505 510 Ala Thr Thr Gly Glu Trp Asp Ala Leu Thr Thr Asp Ser Glu Phe
Gln 515 520 525 Lys Asn Ser Val Ile 530 1171695DNACandida
glabrataCDS(1)..(1695) 117atg tct gag att act ttg ggt aga tac ttg
ttc gag aga ttg aac caa 48Met Ser Glu Ile Thr Leu Gly
Arg Tyr Leu Phe Glu Arg Leu Asn Gln 1 5 10 15 gtc gac gtt aag acc
atc ttc ggt ttg cca ggt gac ttc aac ttg tcc 96Val Asp Val Lys Thr
Ile Phe Gly Leu Pro Gly Asp Phe Asn Leu Ser 20 25 30 cta ttg gac
aag atc tac gaa gtt gaa ggt atg aga tgg gct ggt aac 144Leu Leu Asp
Lys Ile Tyr Glu Val Glu Gly Met Arg Trp Ala Gly Asn 35 40 45 gct
aac gaa ttg aac gct gct tac gct gct gac ggt tac gct aga atc 192Ala
Asn Glu Leu Asn Ala Ala Tyr Ala Ala Asp Gly Tyr Ala Arg Ile 50 55
60 aag ggt atg tcc tgt atc atc acc acc ttc ggt gtc ggt gaa ttg tct
240Lys Gly Met Ser Cys Ile Ile Thr Thr Phe Gly Val Gly Glu Leu Ser
65 70 75 80 gcc ttg aac ggt att gcc ggt tct tac gct gaa cac gtc ggt
gtc ttg 288Ala Leu Asn Gly Ile Ala Gly Ser Tyr Ala Glu His Val Gly
Val Leu 85 90 95 cac gtc gtc ggt gtc cca tcc atc tcc tct caa gct
aag caa ttg ttg 336His Val Val Gly Val Pro Ser Ile Ser Ser Gln Ala
Lys Gln Leu Leu 100 105 110 ttg cac cac acc ttg ggt aac ggt gac ttc
act gtc ttc cac aga atg 384Leu His His Thr Leu Gly Asn Gly Asp Phe
Thr Val Phe His Arg Met 115 120 125 tcc gct aac atc tct gag acc acc
gct atg gtc act gac atc gct acc 432Ser Ala Asn Ile Ser Glu Thr Thr
Ala Met Val Thr Asp Ile Ala Thr 130 135 140 gct cca gct gag atc gac
aga tgt atc aga acc acc tac atc acc caa 480Ala Pro Ala Glu Ile Asp
Arg Cys Ile Arg Thr Thr Tyr Ile Thr Gln 145 150 155 160 aga cca gtc
tac ttg ggt cta cca gct aac ttg gtc gac cta aag gtc 528Arg Pro Val
Tyr Leu Gly Leu Pro Ala Asn Leu Val Asp Leu Lys Val 165 170 175 cca
gcc aag ctt ttg gaa acc cca att gac ttg tcc ttg aag cca aac 576Pro
Ala Lys Leu Leu Glu Thr Pro Ile Asp Leu Ser Leu Lys Pro Asn 180 185
190 gac cca gaa gcc gaa act gaa gtc gtt gac acc gtc ttg gaa ttg atc
624Asp Pro Glu Ala Glu Thr Glu Val Val Asp Thr Val Leu Glu Leu Ile
195 200 205 aag gct gct aag aac cca gtt atc ttg gct gat gct tgt gct
tcc aga 672Lys Ala Ala Lys Asn Pro Val Ile Leu Ala Asp Ala Cys Ala
Ser Arg 210 215 220 cac gac gtc aag gct gaa acc aag aag ttg att gac
gcc act caa ttc 720His Asp Val Lys Ala Glu Thr Lys Lys Leu Ile Asp
Ala Thr Gln Phe 225 230 235 240 cca tcc ttc gtt acc cca atg ggt aag
ggt tcc atc gac gaa caa cac 768Pro Ser Phe Val Thr Pro Met Gly Lys
Gly Ser Ile Asp Glu Gln His 245 250 255 cca aga ttc ggt ggt gtc tac
gtc ggt acc ttg tcc aga cca gaa gtt 816Pro Arg Phe Gly Gly Val Tyr
Val Gly Thr Leu Ser Arg Pro Glu Val 260 265 270 aag gaa gct gtt gaa
tcc gct gac ttg atc ttg tct gtc ggt gct ttg 864Lys Glu Ala Val Glu
Ser Ala Asp Leu Ile Leu Ser Val Gly Ala Leu 275 280 285 ttg tcc gat
ttc aac act ggt tct ttc tct tac tct tac aag acc aag 912Leu Ser Asp
Phe Asn Thr Gly Ser Phe Ser Tyr Ser Tyr Lys Thr Lys 290 295 300 aac
atc gtc gaa ttc cac tct gac tac atc aag atc aga aac gct acc 960Asn
Ile Val Glu Phe His Ser Asp Tyr Ile Lys Ile Arg Asn Ala Thr 305 310
315 320 ttc cca ggt gtc caa atg aag ttc gct ttg caa aag ttg ttg aac
gcc 1008Phe Pro Gly Val Gln Met Lys Phe Ala Leu Gln Lys Leu Leu Asn
Ala 325 330 335 gtc cca gaa gct atc aag ggt tac aag cca gtc cct gtc
cca gct aga 1056Val Pro Glu Ala Ile Lys Gly Tyr Lys Pro Val Pro Val
Pro Ala Arg 340 345 350 gtc cca gaa aac aag tcc tgt gac cca gct acc
cca ttg aag caa gaa 1104Val Pro Glu Asn Lys Ser Cys Asp Pro Ala Thr
Pro Leu Lys Gln Glu 355 360 365 tgg atg tgg aac caa gtt tcc aag ttc
ttg caa gaa ggt gat gtt gtt 1152Trp Met Trp Asn Gln Val Ser Lys Phe
Leu Gln Glu Gly Asp Val Val 370 375 380 atc act gaa acc ggt acc tcc
gct ttt ggt atc aac caa acc cca ttc 1200Ile Thr Glu Thr Gly Thr Ser
Ala Phe Gly Ile Asn Gln Thr Pro Phe 385 390 395 400 cca aac aac gct
tac ggt atc tcc caa gtt cta tgg ggt tcc atc ggt 1248Pro Asn Asn Ala
Tyr Gly Ile Ser Gln Val Leu Trp Gly Ser Ile Gly 405 410 415 ttc acc
acc ggt gct tgt ttg ggt gcc gct ttc gct gct gaa gaa atc 1296Phe Thr
Thr Gly Ala Cys Leu Gly Ala Ala Phe Ala Ala Glu Glu Ile 420 425 430
gac cca aag aag aga gtt atc ttg ttc att ggt gac ggt tct ttg caa
1344Asp Pro Lys Lys Arg Val Ile Leu Phe Ile Gly Asp Gly Ser Leu Gln
435 440 445 ttg act gtc caa gaa atc tcc acc atg atc aga tgg ggc ttg
aag cca 1392Leu Thr Val Gln Glu Ile Ser Thr Met Ile Arg Trp Gly Leu
Lys Pro 450 455 460 tac ttg ttc gtc ttg aac aac gac ggt tac acc atc
gaa aga ttg att 1440Tyr Leu Phe Val Leu Asn Asn Asp Gly Tyr Thr Ile
Glu Arg Leu Ile 465 470 475 480 cac ggt gaa aag gct ggt tac aac gac
atc caa aac tgg gac cac ttg 1488His Gly Glu Lys Ala Gly Tyr Asn Asp
Ile Gln Asn Trp Asp His Leu 485 490 495 gct cta ttg cca acc ttc ggt
gct aag gac tac gaa aac cac aga gtc 1536Ala Leu Leu Pro Thr Phe Gly
Ala Lys Asp Tyr Glu Asn His Arg Val 500 505 510 gcc acc acc ggt gaa
tgg gac aag ttg acc caa gac aag gaa ttc aac 1584Ala Thr Thr Gly Glu
Trp Asp Lys Leu Thr Gln Asp Lys Glu Phe Asn 515 520 525 aag aac tcc
aag atc aga atg atc gaa gtt atg ttg cca gtt atg gac 1632Lys Asn Ser
Lys Ile Arg Met Ile Glu Val Met Leu Pro Val Met Asp 530 535 540 gct
cca act tcc ttg att gaa caa gct aag ttg acc gct tcc atc aac 1680Ala
Pro Thr Ser Leu Ile Glu Gln Ala Lys Leu Thr Ala Ser Ile Asn 545 550
555 560 gct aag caa gaa taa 1695Ala Lys Gln Glu 118564PRTCandida
glabrata 118Met Ser Glu Ile Thr Leu Gly Arg Tyr Leu Phe Glu Arg Leu
Asn Gln 1 5 10 15 Val Asp Val Lys Thr Ile Phe Gly Leu Pro Gly Asp
Phe Asn Leu Ser 20 25 30 Leu Leu Asp Lys Ile Tyr Glu Val Glu Gly
Met Arg Trp Ala Gly Asn 35 40 45 Ala Asn Glu Leu Asn Ala Ala Tyr
Ala Ala Asp Gly Tyr Ala Arg Ile 50 55 60 Lys Gly Met Ser Cys Ile
Ile Thr Thr Phe Gly Val Gly Glu Leu Ser 65 70 75 80 Ala Leu Asn Gly
Ile Ala Gly Ser Tyr Ala Glu His Val Gly Val Leu 85 90 95 His Val
Val Gly Val Pro Ser Ile Ser Ser Gln Ala Lys Gln Leu Leu 100 105 110
Leu His His Thr Leu Gly Asn Gly Asp Phe Thr Val Phe His Arg Met 115
120 125 Ser Ala Asn Ile Ser Glu Thr Thr Ala Met Val Thr Asp Ile Ala
Thr 130 135 140 Ala Pro Ala Glu Ile Asp Arg Cys Ile Arg Thr Thr Tyr
Ile Thr Gln 145 150 155 160 Arg Pro Val Tyr Leu Gly Leu Pro Ala Asn
Leu Val Asp Leu Lys Val 165 170 175 Pro Ala Lys Leu Leu Glu Thr Pro
Ile Asp Leu Ser Leu Lys Pro Asn 180 185 190 Asp Pro Glu Ala Glu Thr
Glu Val Val Asp Thr Val Leu Glu Leu Ile 195 200 205 Lys Ala Ala Lys
Asn Pro Val Ile Leu Ala Asp Ala Cys Ala Ser Arg 210 215 220 His Asp
Val Lys Ala Glu Thr Lys Lys Leu Ile Asp Ala Thr Gln Phe 225 230 235
240 Pro Ser Phe Val Thr Pro Met Gly Lys Gly Ser Ile Asp Glu Gln His
245 250 255 Pro Arg Phe Gly Gly Val Tyr Val Gly Thr Leu Ser Arg Pro
Glu Val 260 265 270 Lys Glu Ala Val Glu Ser Ala Asp Leu Ile Leu Ser
Val Gly Ala Leu 275 280 285 Leu Ser Asp Phe Asn Thr Gly Ser Phe Ser
Tyr Ser Tyr Lys Thr Lys 290 295 300 Asn Ile Val Glu Phe His Ser Asp
Tyr Ile Lys Ile Arg Asn Ala Thr 305 310 315 320 Phe Pro Gly Val Gln
Met Lys Phe Ala Leu Gln Lys Leu Leu Asn Ala 325 330 335 Val Pro Glu
Ala Ile Lys Gly Tyr Lys Pro Val Pro Val Pro Ala Arg 340 345 350 Val
Pro Glu Asn Lys Ser Cys Asp Pro Ala Thr Pro Leu Lys Gln Glu 355 360
365 Trp Met Trp Asn Gln Val Ser Lys Phe Leu Gln Glu Gly Asp Val Val
370 375 380 Ile Thr Glu Thr Gly Thr Ser Ala Phe Gly Ile Asn Gln Thr
Pro Phe 385 390 395 400 Pro Asn Asn Ala Tyr Gly Ile Ser Gln Val Leu
Trp Gly Ser Ile Gly 405 410 415 Phe Thr Thr Gly Ala Cys Leu Gly Ala
Ala Phe Ala Ala Glu Glu Ile 420 425 430 Asp Pro Lys Lys Arg Val Ile
Leu Phe Ile Gly Asp Gly Ser Leu Gln 435 440 445 Leu Thr Val Gln Glu
Ile Ser Thr Met Ile Arg Trp Gly Leu Lys Pro 450 455 460 Tyr Leu Phe
Val Leu Asn Asn Asp Gly Tyr Thr Ile Glu Arg Leu Ile 465 470 475 480
His Gly Glu Lys Ala Gly Tyr Asn Asp Ile Gln Asn Trp Asp His Leu 485
490 495 Ala Leu Leu Pro Thr Phe Gly Ala Lys Asp Tyr Glu Asn His Arg
Val 500 505 510 Ala Thr Thr Gly Glu Trp Asp Lys Leu Thr Gln Asp Lys
Glu Phe Asn 515 520 525 Lys Asn Ser Lys Ile Arg Met Ile Glu Val Met
Leu Pro Val Met Asp 530 535 540 Ala Pro Thr Ser Leu Ile Glu Gln Ala
Lys Leu Thr Ala Ser Ile Asn 545 550 555 560 Ala Lys Gln Glu
1191791DNAPichia stipitisCDS(1)..(1791) 119atg gct gaa gtc tca tta
gga aga tat ctc ttc gag aga ttg tac caa 48Met Ala Glu Val Ser Leu
Gly Arg Tyr Leu Phe Glu Arg Leu Tyr Gln 1 5 10 15 ttg caa gtg cag
acc atc ttc ggt gtc cct ggt gat ttc aac ttg tcg 96Leu Gln Val Gln
Thr Ile Phe Gly Val Pro Gly Asp Phe Asn Leu Ser 20 25 30 ctt ttg
gac aag atc tac gaa gtg gaa gat gcc cat ggc aag aat tcg 144Leu Leu
Asp Lys Ile Tyr Glu Val Glu Asp Ala His Gly Lys Asn Ser 35 40 45
ttt aga tgg gct ggt aat gcc aac gaa ttg aat gca tcg tac gct gct
192Phe Arg Trp Ala Gly Asn Ala Asn Glu Leu Asn Ala Ser Tyr Ala Ala
50 55 60 gac ggt tac tcg aga gtc aag cgt tta ggg tgt ttg gtc act
acc ttt 240Asp Gly Tyr Ser Arg Val Lys Arg Leu Gly Cys Leu Val Thr
Thr Phe 65 70 75 80 ggt gtc ggt gaa ttg tct gct ttg aat ggt att gcc
ggt tct tat gcc 288Gly Val Gly Glu Leu Ser Ala Leu Asn Gly Ile Ala
Gly Ser Tyr Ala 85 90 95 gaa cat gtt ggt ttg ctt cat gtc gta ggt
gtt cca tcg att tcc tcg 336Glu His Val Gly Leu Leu His Val Val Gly
Val Pro Ser Ile Ser Ser 100 105 110 caa gct aag caa ttg tta ctt cac
cac act ttg ggt aat ggt gat ttc 384Gln Ala Lys Gln Leu Leu Leu His
His Thr Leu Gly Asn Gly Asp Phe 115 120 125 act gtt ttc cat aga atg
tcc aac aac att tct cag acc aca gcc ttt 432Thr Val Phe His Arg Met
Ser Asn Asn Ile Ser Gln Thr Thr Ala Phe 130 135 140 atc tcc gat atc
aac tcg gct cca gct gaa att gat aga tgt atc aga 480Ile Ser Asp Ile
Asn Ser Ala Pro Ala Glu Ile Asp Arg Cys Ile Arg 145 150 155 160 gag
gcc tac gtc aaa caa aga cca gtt tat atc ggg tta cca gct aac 528Glu
Ala Tyr Val Lys Gln Arg Pro Val Tyr Ile Gly Leu Pro Ala Asn 165 170
175 tta gtt gat ttg aat gtt ccg gcc tct ttg ctt gag tct cca atc aac
576Leu Val Asp Leu Asn Val Pro Ala Ser Leu Leu Glu Ser Pro Ile Asn
180 185 190 ttg tcg ttg gaa aag aac gac cca gag gct caa gat gaa gtc
att gac 624Leu Ser Leu Glu Lys Asn Asp Pro Glu Ala Gln Asp Glu Val
Ile Asp 195 200 205 tct gtc tta gac ttg atc aaa aag tcg ctg aac cca
atc atc ttg gtc 672Ser Val Leu Asp Leu Ile Lys Lys Ser Leu Asn Pro
Ile Ile Leu Val 210 215 220 gat gcc tgt gcc tcg aga cat gac tgt aag
gct gaa gtt act cag ttg 720Asp Ala Cys Ala Ser Arg His Asp Cys Lys
Ala Glu Val Thr Gln Leu 225 230 235 240 att gaa caa acc caa ttc cca
gta ttt gtc act cca atg ggt aaa ggt 768Ile Glu Gln Thr Gln Phe Pro
Val Phe Val Thr Pro Met Gly Lys Gly 245 250 255 acc gtt gat gag ggt
ggt gta gac gga gaa ttg tta gaa gat gat cct 816Thr Val Asp Glu Gly
Gly Val Asp Gly Glu Leu Leu Glu Asp Asp Pro 260 265 270 cat ttg att
gcc aag gtc gct gct agg ttg tct gct ggc aag aac gct 864His Leu Ile
Ala Lys Val Ala Ala Arg Leu Ser Ala Gly Lys Asn Ala 275 280 285 gcc
tct aga ttc gga ggt gtt tat gtc gga acc ttg tcg aag ccc gaa 912Ala
Ser Arg Phe Gly Gly Val Tyr Val Gly Thr Leu Ser Lys Pro Glu 290 295
300 gtc aag gac gct gta gag agt gca gat ttg att ttg tct gtc ggt gcc
960Val Lys Asp Ala Val Glu Ser Ala Asp Leu Ile Leu Ser Val Gly Ala
305 310 315 320 ctt ttg tct gat ttc aac act ggt tca ttt tcc tac tcc
tac aga acc 1008Leu Leu Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr Ser
Tyr Arg Thr 325 330 335 aag aac atc gtc gaa ttc cat tct gat tac act
aag att aga caa gcc 1056Lys Asn Ile Val Glu Phe His Ser Asp Tyr Thr
Lys Ile Arg Gln Ala 340 345 350 act ttc cca ggt gtg cag atg aag gaa
gcc ttg caa gaa ttg aac aag 1104Thr Phe Pro Gly Val Gln Met Lys Glu
Ala Leu Gln Glu Leu Asn Lys 355 360 365 aaa gtt tca tct gct gct agt
cac tat gaa gtc aag cct gtg ccc aag 1152Lys Val Ser Ser Ala Ala Ser
His Tyr Glu Val Lys Pro Val Pro Lys 370 375 380 atc aag ttg gcc aat
aca cca gcc acc aga gaa gtc aag tta act cag 1200Ile Lys Leu Ala Asn
Thr Pro Ala Thr Arg Glu Val Lys Leu Thr Gln 385 390 395 400 gaa tgg
ttg tgg acc aga gtg tct tcg tgg ttc aga gaa ggt gat att 1248Glu Trp
Leu Trp Thr Arg Val Ser Ser Trp Phe Arg Glu Gly Asp Ile 405 410 415
att atc acc gaa acc ggt aca tcc tcc ttc ggt ata gtt caa tcc aga
1296Ile Ile Thr Glu Thr Gly Thr Ser Ser Phe Gly Ile Val Gln Ser Arg
420 425 430 ttc cca aac aac acc atc ggt atc tcc caa gta ttg tgg ggt
tct att 1344Phe Pro Asn Asn Thr Ile Gly Ile Ser Gln Val Leu Trp Gly
Ser Ile 435
440 445 ggt ttc tct gtt ggt gcc act ttg ggt gct gcc atg gct gcc caa
gaa 1392Gly Phe Ser Val Gly Ala Thr Leu Gly Ala Ala Met Ala Ala Gln
Glu 450 455 460 ctc gac cct aac aag aga acc atc ttg ttt gtt gga gat
ggt tct ttg 1440Leu Asp Pro Asn Lys Arg Thr Ile Leu Phe Val Gly Asp
Gly Ser Leu 465 470 475 480 caa ttg acc gtt cag gaa atc tcc acc ata
atc aga tgg ggt acc aca 1488Gln Leu Thr Val Gln Glu Ile Ser Thr Ile
Ile Arg Trp Gly Thr Thr 485 490 495 cct tac ctt ttc gtg ttg aac aat
gac ggt tac acc atc gag cgt ttg 1536Pro Tyr Leu Phe Val Leu Asn Asn
Asp Gly Tyr Thr Ile Glu Arg Leu 500 505 510 atc cac ggt gta aat gcc
tca tat aat gac atc caa cca tgg caa aac 1584Ile His Gly Val Asn Ala
Ser Tyr Asn Asp Ile Gln Pro Trp Gln Asn 515 520 525 ttg gaa atc ttg
cct act ttc tcg gcc aag aac tac gac gct gtg aga 1632Leu Glu Ile Leu
Pro Thr Phe Ser Ala Lys Asn Tyr Asp Ala Val Arg 530 535 540 atc tcc
aac atc gga gaa gca gaa gat atc ttg aaa gac aag gaa ttc 1680Ile Ser
Asn Ile Gly Glu Ala Glu Asp Ile Leu Lys Asp Lys Glu Phe 545 550 555
560 gga aag aac tcc aag att aga ttg ata gaa gtc atg tta cca aga ttg
1728Gly Lys Asn Ser Lys Ile Arg Leu Ile Glu Val Met Leu Pro Arg Leu
565 570 575 gat gca cca tct aac ctt gcc aaa caa gct gcc att aca gct
gcc acc 1776Asp Ala Pro Ser Asn Leu Ala Lys Gln Ala Ala Ile Thr Ala
Ala Thr 580 585 590 aac gcc gaa gct tag 1791Asn Ala Glu Ala 595
120596PRTPichia stipitis 120Met Ala Glu Val Ser Leu Gly Arg Tyr Leu
Phe Glu Arg Leu Tyr Gln 1 5 10 15 Leu Gln Val Gln Thr Ile Phe Gly
Val Pro Gly Asp Phe Asn Leu Ser 20 25 30 Leu Leu Asp Lys Ile Tyr
Glu Val Glu Asp Ala His Gly Lys Asn Ser 35 40 45 Phe Arg Trp Ala
Gly Asn Ala Asn Glu Leu Asn Ala Ser Tyr Ala Ala 50 55 60 Asp Gly
Tyr Ser Arg Val Lys Arg Leu Gly Cys Leu Val Thr Thr Phe 65 70 75 80
Gly Val Gly Glu Leu Ser Ala Leu Asn Gly Ile Ala Gly Ser Tyr Ala 85
90 95 Glu His Val Gly Leu Leu His Val Val Gly Val Pro Ser Ile Ser
Ser 100 105 110 Gln Ala Lys Gln Leu Leu Leu His His Thr Leu Gly Asn
Gly Asp Phe 115 120 125 Thr Val Phe His Arg Met Ser Asn Asn Ile Ser
Gln Thr Thr Ala Phe 130 135 140 Ile Ser Asp Ile Asn Ser Ala Pro Ala
Glu Ile Asp Arg Cys Ile Arg 145 150 155 160 Glu Ala Tyr Val Lys Gln
Arg Pro Val Tyr Ile Gly Leu Pro Ala Asn 165 170 175 Leu Val Asp Leu
Asn Val Pro Ala Ser Leu Leu Glu Ser Pro Ile Asn 180 185 190 Leu Ser
Leu Glu Lys Asn Asp Pro Glu Ala Gln Asp Glu Val Ile Asp 195 200 205
Ser Val Leu Asp Leu Ile Lys Lys Ser Leu Asn Pro Ile Ile Leu Val 210
215 220 Asp Ala Cys Ala Ser Arg His Asp Cys Lys Ala Glu Val Thr Gln
Leu 225 230 235 240 Ile Glu Gln Thr Gln Phe Pro Val Phe Val Thr Pro
Met Gly Lys Gly 245 250 255 Thr Val Asp Glu Gly Gly Val Asp Gly Glu
Leu Leu Glu Asp Asp Pro 260 265 270 His Leu Ile Ala Lys Val Ala Ala
Arg Leu Ser Ala Gly Lys Asn Ala 275 280 285 Ala Ser Arg Phe Gly Gly
Val Tyr Val Gly Thr Leu Ser Lys Pro Glu 290 295 300 Val Lys Asp Ala
Val Glu Ser Ala Asp Leu Ile Leu Ser Val Gly Ala 305 310 315 320 Leu
Leu Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr Ser Tyr Arg Thr 325 330
335 Lys Asn Ile Val Glu Phe His Ser Asp Tyr Thr Lys Ile Arg Gln Ala
340 345 350 Thr Phe Pro Gly Val Gln Met Lys Glu Ala Leu Gln Glu Leu
Asn Lys 355 360 365 Lys Val Ser Ser Ala Ala Ser His Tyr Glu Val Lys
Pro Val Pro Lys 370 375 380 Ile Lys Leu Ala Asn Thr Pro Ala Thr Arg
Glu Val Lys Leu Thr Gln 385 390 395 400 Glu Trp Leu Trp Thr Arg Val
Ser Ser Trp Phe Arg Glu Gly Asp Ile 405 410 415 Ile Ile Thr Glu Thr
Gly Thr Ser Ser Phe Gly Ile Val Gln Ser Arg 420 425 430 Phe Pro Asn
Asn Thr Ile Gly Ile Ser Gln Val Leu Trp Gly Ser Ile 435 440 445 Gly
Phe Ser Val Gly Ala Thr Leu Gly Ala Ala Met Ala Ala Gln Glu 450 455
460 Leu Asp Pro Asn Lys Arg Thr Ile Leu Phe Val Gly Asp Gly Ser Leu
465 470 475 480 Gln Leu Thr Val Gln Glu Ile Ser Thr Ile Ile Arg Trp
Gly Thr Thr 485 490 495 Pro Tyr Leu Phe Val Leu Asn Asn Asp Gly Tyr
Thr Ile Glu Arg Leu 500 505 510 Ile His Gly Val Asn Ala Ser Tyr Asn
Asp Ile Gln Pro Trp Gln Asn 515 520 525 Leu Glu Ile Leu Pro Thr Phe
Ser Ala Lys Asn Tyr Asp Ala Val Arg 530 535 540 Ile Ser Asn Ile Gly
Glu Ala Glu Asp Ile Leu Lys Asp Lys Glu Phe 545 550 555 560 Gly Lys
Asn Ser Lys Ile Arg Leu Ile Glu Val Met Leu Pro Arg Leu 565 570 575
Asp Ala Pro Ser Asn Leu Ala Lys Gln Ala Ala Ile Thr Ala Ala Thr 580
585 590 Asn Ala Glu Ala 595 1211710DNAPichia stipitisCDS(1)..(1710)
121atg gta tca acc tac cca gaa tca gag gtt act cta gga agg tac ctc
48Met Val Ser Thr Tyr Pro Glu Ser Glu Val Thr Leu Gly Arg Tyr Leu 1
5 10 15 ttt gag cga ctc cac caa ttg aaa gtg gac acc att ttc ggc ttg
ccg 96Phe Glu Arg Leu His Gln Leu Lys Val Asp Thr Ile Phe Gly Leu
Pro 20 25 30 ggt gac ttc aac ctt tcc tta ttg gac aaa gtg tat gaa
gtt ccg gat 144Gly Asp Phe Asn Leu Ser Leu Leu Asp Lys Val Tyr Glu
Val Pro Asp 35 40 45 atg agg tgg gct gga aat gcc aac gaa ttg aat
gct gcc tat gct gcc 192Met Arg Trp Ala Gly Asn Ala Asn Glu Leu Asn
Ala Ala Tyr Ala Ala 50 55 60 gat ggt tac tcc aga ata aag gga ttg
tct tgc ttg gtc aca act ttt 240Asp Gly Tyr Ser Arg Ile Lys Gly Leu
Ser Cys Leu Val Thr Thr Phe 65 70 75 80 ggt gtt ggt gaa ttg tct gct
tta aac gga gtt ggt ggt gcc tat gct 288Gly Val Gly Glu Leu Ser Ala
Leu Asn Gly Val Gly Gly Ala Tyr Ala 85 90 95 gaa cac gta gga ctt
cta cat gtc gtt gga gtt cca tcc ata tcg tca 336Glu His Val Gly Leu
Leu His Val Val Gly Val Pro Ser Ile Ser Ser 100 105 110 cag gct aaa
cag ttg ttg ctc cac cat acc ttg ggt aat ggt gac ttc 384Gln Ala Lys
Gln Leu Leu Leu His His Thr Leu Gly Asn Gly Asp Phe 115 120 125 act
gtt ttt cac aga atg tcc aat agc att tct caa act aca gca ttt 432Thr
Val Phe His Arg Met Ser Asn Ser Ile Ser Gln Thr Thr Ala Phe 130 135
140 ctc tca gat atc tct att gca cca ggt caa ata gat aga tgc atc aga
480Leu Ser Asp Ile Ser Ile Ala Pro Gly Gln Ile Asp Arg Cys Ile Arg
145 150 155 160 gaa gca tat gtt cat cag aga cca gtt tat gtt ggt tta
ccg gca aat 528Glu Ala Tyr Val His Gln Arg Pro Val Tyr Val Gly Leu
Pro Ala Asn 165 170 175 atg gtt gat ctc aag gtt cct tct agt ctc tta
gaa act cca att gat 576Met Val Asp Leu Lys Val Pro Ser Ser Leu Leu
Glu Thr Pro Ile Asp 180 185 190 ttg aaa ttg aaa caa aat gat cct gaa
gct caa gaa gtt gtt gaa aca 624Leu Lys Leu Lys Gln Asn Asp Pro Glu
Ala Gln Glu Val Val Glu Thr 195 200 205 gtc ctg aag ttg gtg tcc caa
gct aca aac ccc att atc ttg gta gac 672Val Leu Lys Leu Val Ser Gln
Ala Thr Asn Pro Ile Ile Leu Val Asp 210 215 220 gct tgt gcc ctc aga
cac aat tgc aaa gag gaa gtc aaa caa ttg gtt 720Ala Cys Ala Leu Arg
His Asn Cys Lys Glu Glu Val Lys Gln Leu Val 225 230 235 240 gat gcc
act aat ttt caa gtc ttt aca act cca atg ggt aaa tct ggt 768Asp Ala
Thr Asn Phe Gln Val Phe Thr Thr Pro Met Gly Lys Ser Gly 245 250 255
atc tcc gaa tct cat cca aga ttg ggc ggt gtc tat gtc ggg aca atg
816Ile Ser Glu Ser His Pro Arg Leu Gly Gly Val Tyr Val Gly Thr Met
260 265 270 tcg agt cct caa gtc aaa aaa gcc gtt gaa aat gcc gat ctt
ata cta 864Ser Ser Pro Gln Val Lys Lys Ala Val Glu Asn Ala Asp Leu
Ile Leu 275 280 285 tct gtt ggt tcg ttg tta tcg gac ttc aat aca ggt
tca ttt tca tac 912Ser Val Gly Ser Leu Leu Ser Asp Phe Asn Thr Gly
Ser Phe Ser Tyr 290 295 300 tcc tac aag acg aag aat gtt gtt gaa ttc
cac tct gac tat atg aaa 960Ser Tyr Lys Thr Lys Asn Val Val Glu Phe
His Ser Asp Tyr Met Lys 305 310 315 320 atc aga cag gcc acc ttc cca
gga gtt caa atg aaa gaa gcc ttg caa 1008Ile Arg Gln Ala Thr Phe Pro
Gly Val Gln Met Lys Glu Ala Leu Gln 325 330 335 cag ttg ata aaa agg
gtc tct tct tac atc aat cca agc tac att cct 1056Gln Leu Ile Lys Arg
Val Ser Ser Tyr Ile Asn Pro Ser Tyr Ile Pro 340 345 350 act cga gtt
cct aaa agg aaa cag cca ttg aaa gct cca tca gaa gct 1104Thr Arg Val
Pro Lys Arg Lys Gln Pro Leu Lys Ala Pro Ser Glu Ala 355 360 365 cct
ttg acc caa gaa tat ttg tgg tct aaa gta tcc ggc tgg ttt aga 1152Pro
Leu Thr Gln Glu Tyr Leu Trp Ser Lys Val Ser Gly Trp Phe Arg 370 375
380 gag ggt gat att atc gta acc gaa act ggt aca tct gct ttc gga att
1200Glu Gly Asp Ile Ile Val Thr Glu Thr Gly Thr Ser Ala Phe Gly Ile
385 390 395 400 att caa tcc cat ttt ccc agc aac act atc ggt ata tcc
caa gtc ttg 1248Ile Gln Ser His Phe Pro Ser Asn Thr Ile Gly Ile Ser
Gln Val Leu 405 410 415 tgg ggc tca att ggt ttc aca gta ggt gca aca
gtt ggt gct gcc atg 1296Trp Gly Ser Ile Gly Phe Thr Val Gly Ala Thr
Val Gly Ala Ala Met 420 425 430 gca gcc cag gaa atc gac cct agc agg
aga gta att ttg ttc gtc ggt 1344Ala Ala Gln Glu Ile Asp Pro Ser Arg
Arg Val Ile Leu Phe Val Gly 435 440 445 gat ggt tca ttg cag ttg acg
gtt cag gaa atc tct acg ttg tgt aaa 1392Asp Gly Ser Leu Gln Leu Thr
Val Gln Glu Ile Ser Thr Leu Cys Lys 450 455 460 tgg gat tgt aac aat
act tat ctt tac gtg ttg aac aat gat ggt tac 1440Trp Asp Cys Asn Asn
Thr Tyr Leu Tyr Val Leu Asn Asn Asp Gly Tyr 465 470 475 480 act ata
gaa agg ttg atc cac ggc aaa agt gcc agc tac aac gat ata 1488Thr Ile
Glu Arg Leu Ile His Gly Lys Ser Ala Ser Tyr Asn Asp Ile 485 490 495
cag cct tgg aac cat tta tcc ttg ctt cgc tta ttc aat gct aag aaa
1536Gln Pro Trp Asn His Leu Ser Leu Leu Arg Leu Phe Asn Ala Lys Lys
500 505 510 tac caa aat gtc aga gta tcg act gct gga gaa ttg gac tct
ttg ttc 1584Tyr Gln Asn Val Arg Val Ser Thr Ala Gly Glu Leu Asp Ser
Leu Phe 515 520 525 tct gat aag aaa ttt gct tct cca gat agg ata aga
atg att gag gtg 1632Ser Asp Lys Lys Phe Ala Ser Pro Asp Arg Ile Arg
Met Ile Glu Val 530 535 540 atg tta tcg aga ttg gat gca cca gca aat
ctt gtt gct caa gca aag 1680Met Leu Ser Arg Leu Asp Ala Pro Ala Asn
Leu Val Ala Gln Ala Lys 545 550 555 560 ttg tct gaa cgg gta aac ctt
gaa aat tga 1710Leu Ser Glu Arg Val Asn Leu Glu Asn 565
122569PRTPichia stipitis 122Met Val Ser Thr Tyr Pro Glu Ser Glu Val
Thr Leu Gly Arg Tyr Leu 1 5 10 15 Phe Glu Arg Leu His Gln Leu Lys
Val Asp Thr Ile Phe Gly Leu Pro 20 25 30 Gly Asp Phe Asn Leu Ser
Leu Leu Asp Lys Val Tyr Glu Val Pro Asp 35 40 45 Met Arg Trp Ala
Gly Asn Ala Asn Glu Leu Asn Ala Ala Tyr Ala Ala 50 55 60 Asp Gly
Tyr Ser Arg Ile Lys Gly Leu Ser Cys Leu Val Thr Thr Phe 65 70 75 80
Gly Val Gly Glu Leu Ser Ala Leu Asn Gly Val Gly Gly Ala Tyr Ala 85
90 95 Glu His Val Gly Leu Leu His Val Val Gly Val Pro Ser Ile Ser
Ser 100 105 110 Gln Ala Lys Gln Leu Leu Leu His His Thr Leu Gly Asn
Gly Asp Phe 115 120 125 Thr Val Phe His Arg Met Ser Asn Ser Ile Ser
Gln Thr Thr Ala Phe 130 135 140 Leu Ser Asp Ile Ser Ile Ala Pro Gly
Gln Ile Asp Arg Cys Ile Arg 145 150 155 160 Glu Ala Tyr Val His Gln
Arg Pro Val Tyr Val Gly Leu Pro Ala Asn 165 170 175 Met Val Asp Leu
Lys Val Pro Ser Ser Leu Leu Glu Thr Pro Ile Asp 180 185 190 Leu Lys
Leu Lys Gln Asn Asp Pro Glu Ala Gln Glu Val Val Glu Thr 195 200 205
Val Leu Lys Leu Val Ser Gln Ala Thr Asn Pro Ile Ile Leu Val Asp 210
215 220 Ala Cys Ala Leu Arg His Asn Cys Lys Glu Glu Val Lys Gln Leu
Val 225 230 235 240 Asp Ala Thr Asn Phe Gln Val Phe Thr Thr Pro Met
Gly Lys Ser Gly 245 250 255 Ile Ser Glu Ser His Pro Arg Leu Gly Gly
Val Tyr Val Gly Thr Met 260 265 270 Ser Ser Pro Gln Val Lys Lys Ala
Val Glu Asn Ala Asp Leu Ile Leu 275 280 285 Ser Val Gly Ser Leu Leu
Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr 290 295 300 Ser Tyr Lys Thr
Lys Asn Val Val Glu Phe His Ser Asp Tyr Met Lys 305 310 315 320 Ile
Arg Gln Ala Thr Phe Pro Gly Val Gln Met Lys Glu Ala Leu Gln 325 330
335 Gln Leu Ile Lys Arg Val Ser Ser Tyr Ile Asn Pro Ser Tyr Ile Pro
340 345 350 Thr Arg Val Pro Lys Arg Lys Gln Pro Leu Lys Ala Pro Ser
Glu Ala 355 360 365 Pro Leu Thr Gln Glu Tyr Leu Trp Ser Lys Val Ser
Gly Trp Phe Arg 370 375 380 Glu Gly Asp Ile Ile Val Thr Glu Thr Gly
Thr Ser Ala Phe Gly Ile 385 390 395 400 Ile Gln Ser His Phe Pro Ser
Asn Thr Ile Gly Ile Ser Gln Val Leu 405 410 415 Trp Gly Ser Ile Gly
Phe Thr Val Gly Ala Thr Val Gly Ala Ala Met 420
425 430 Ala Ala Gln Glu Ile Asp Pro Ser Arg Arg Val Ile Leu Phe Val
Gly 435 440 445 Asp Gly Ser Leu Gln Leu Thr Val Gln Glu Ile Ser Thr
Leu Cys Lys 450 455 460 Trp Asp Cys Asn Asn Thr Tyr Leu Tyr Val Leu
Asn Asn Asp Gly Tyr 465 470 475 480 Thr Ile Glu Arg Leu Ile His Gly
Lys Ser Ala Ser Tyr Asn Asp Ile 485 490 495 Gln Pro Trp Asn His Leu
Ser Leu Leu Arg Leu Phe Asn Ala Lys Lys 500 505 510 Tyr Gln Asn Val
Arg Val Ser Thr Ala Gly Glu Leu Asp Ser Leu Phe 515 520 525 Ser Asp
Lys Lys Phe Ala Ser Pro Asp Arg Ile Arg Met Ile Glu Val 530 535 540
Met Leu Ser Arg Leu Asp Ala Pro Ala Asn Leu Val Ala Gln Ala Lys 545
550 555 560 Leu Ser Glu Arg Val Asn Leu Glu Asn 565
1231692DNAKluyveromyces lactisCDS(1)..(1692) 123atg tct gaa att aca
tta ggt cgt tac ttg ttc gaa aga tta aag caa 48Met Ser Glu Ile Thr
Leu Gly Arg Tyr Leu Phe Glu Arg Leu Lys Gln 1 5 10 15 gtc gaa gtt
caa acc atc ttt ggt cta cca ggt gat ttc aac ttg tcc 96Val Glu Val
Gln Thr Ile Phe Gly Leu Pro Gly Asp Phe Asn Leu Ser 20 25 30 cta
ttg gac aat atc tac gaa gtc cca ggt atg aga tgg gct ggt aat 144Leu
Leu Asp Asn Ile Tyr Glu Val Pro Gly Met Arg Trp Ala Gly Asn 35 40
45 gcc aac gaa ttg aac gct gct tac gct gct gat ggt tac gcc aga tta
192Ala Asn Glu Leu Asn Ala Ala Tyr Ala Ala Asp Gly Tyr Ala Arg Leu
50 55 60 aag ggt atg tcc tgt atc atc acc acc ttc ggt gtc ggt gaa
ttg tct 240Lys Gly Met Ser Cys Ile Ile Thr Thr Phe Gly Val Gly Glu
Leu Ser 65 70 75 80 gct ttg aac ggt att gcc ggt tct tac gct gaa cac
gtt ggt gtc ttg 288Ala Leu Asn Gly Ile Ala Gly Ser Tyr Ala Glu His
Val Gly Val Leu 85 90 95 cac gtt gtc ggt gtt cca tcc gtc tct tct
caa gct aag caa ttg ttg 336His Val Val Gly Val Pro Ser Val Ser Ser
Gln Ala Lys Gln Leu Leu 100 105 110 ttg cac cac acc ttg ggt aac ggt
gac ttc act gtt ttc cac aga atg 384Leu His His Thr Leu Gly Asn Gly
Asp Phe Thr Val Phe His Arg Met 115 120 125 tcc tcc aac att tct gaa
acc act gct atg atc acc gat atc aac act 432Ser Ser Asn Ile Ser Glu
Thr Thr Ala Met Ile Thr Asp Ile Asn Thr 130 135 140 gcc cca gct gaa
atc gac aga tgt atc aga acc act tac gtt tcc caa 480Ala Pro Ala Glu
Ile Asp Arg Cys Ile Arg Thr Thr Tyr Val Ser Gln 145 150 155 160 aga
cca gtc tac ttg ggt ttg cca gct aac ttg gtc gac ttg act gtc 528Arg
Pro Val Tyr Leu Gly Leu Pro Ala Asn Leu Val Asp Leu Thr Val 165 170
175 cca gct tct ttg ttg gac act cca att gat ttg agc ttg aag cca aat
576Pro Ala Ser Leu Leu Asp Thr Pro Ile Asp Leu Ser Leu Lys Pro Asn
180 185 190 gac cca gaa gcc gaa gaa gaa gtc atc gaa aac gtc ttg caa
ctg atc 624Asp Pro Glu Ala Glu Glu Glu Val Ile Glu Asn Val Leu Gln
Leu Ile 195 200 205 aag gaa gct aag aac cca gtt atc ttg gct gat gct
tgt tgt tcc aga 672Lys Glu Ala Lys Asn Pro Val Ile Leu Ala Asp Ala
Cys Cys Ser Arg 210 215 220 cac gat gcc aag gct gag acc aag aag ttg
atc gac ttg act caa ttc 720His Asp Ala Lys Ala Glu Thr Lys Lys Leu
Ile Asp Leu Thr Gln Phe 225 230 235 240 cca gcc ttc gtt acc cca atg
ggt aag ggt tcc att gac gaa aag cac 768Pro Ala Phe Val Thr Pro Met
Gly Lys Gly Ser Ile Asp Glu Lys His 245 250 255 cca aga ttc ggt ggt
gtc tac gtc ggt acc cta tct tct cca gct gtc 816Pro Arg Phe Gly Gly
Val Tyr Val Gly Thr Leu Ser Ser Pro Ala Val 260 265 270 aag gaa gcc
gtt gaa tct gct gac ttg gtt cta tcg gtc ggt gct cta 864Lys Glu Ala
Val Glu Ser Ala Asp Leu Val Leu Ser Val Gly Ala Leu 275 280 285 ttg
tcc gat ttc aac act ggt tct ttc tct tac tct tac aag acc aag 912Leu
Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr Ser Tyr Lys Thr Lys 290 295
300 aac att gtc gaa ttc cac tct gac tac acc aag atc aga agc gct acc
960Asn Ile Val Glu Phe His Ser Asp Tyr Thr Lys Ile Arg Ser Ala Thr
305 310 315 320 ttc cca ggt gtc caa atg aag ttc gct tta caa aaa ttg
ttg act aag 1008Phe Pro Gly Val Gln Met Lys Phe Ala Leu Gln Lys Leu
Leu Thr Lys 325 330 335 gtt gcc gat gct gct aag ggt tac aag cca gtt
cca gtt cca tct gaa 1056Val Ala Asp Ala Ala Lys Gly Tyr Lys Pro Val
Pro Val Pro Ser Glu 340 345 350 cca gaa cac aac gaa gct gtc gct gac
tcc act cca ttg aag caa gaa 1104Pro Glu His Asn Glu Ala Val Ala Asp
Ser Thr Pro Leu Lys Gln Glu 355 360 365 tgg gtc tgg act caa gtc ggt
gaa ttc ttg aga gaa ggt gat gtt gtt 1152Trp Val Trp Thr Gln Val Gly
Glu Phe Leu Arg Glu Gly Asp Val Val 370 375 380 atc act gaa acc ggt
acc tct gcc ttc ggt atc aac caa act cat ttc 1200Ile Thr Glu Thr Gly
Thr Ser Ala Phe Gly Ile Asn Gln Thr His Phe 385 390 395 400 cca aac
aac aca tac ggt atc tct caa gtt tta tgg ggt tcc att ggt 1248Pro Asn
Asn Thr Tyr Gly Ile Ser Gln Val Leu Trp Gly Ser Ile Gly 405 410 415
ttc acc act ggt gct acc ttg ggt gct gcc ttc gct gcc gaa gaa att
1296Phe Thr Thr Gly Ala Thr Leu Gly Ala Ala Phe Ala Ala Glu Glu Ile
420 425 430 gat cca aag aag aga gtt atc tta ttc att ggt gac ggt tct
ttg caa 1344Asp Pro Lys Lys Arg Val Ile Leu Phe Ile Gly Asp Gly Ser
Leu Gln 435 440 445 ttg act gtt caa gaa atc tcc acc atg atc aga tgg
ggc ttg aag cca 1392Leu Thr Val Gln Glu Ile Ser Thr Met Ile Arg Trp
Gly Leu Lys Pro 450 455 460 tac ttg ttc gta ttg aac aac gac ggt tac
acc att gaa aga ttg att 1440Tyr Leu Phe Val Leu Asn Asn Asp Gly Tyr
Thr Ile Glu Arg Leu Ile 465 470 475 480 cac ggt gaa acc gct caa tac
aac tgt atc caa aac tgg caa cac ttg 1488His Gly Glu Thr Ala Gln Tyr
Asn Cys Ile Gln Asn Trp Gln His Leu 485 490 495 gaa tta ttg cca act
ttc ggt gcc aag gac tac gaa gct gtc aga gtt 1536Glu Leu Leu Pro Thr
Phe Gly Ala Lys Asp Tyr Glu Ala Val Arg Val 500 505 510 tcc acc act
ggt gaa tgg aac aag ttg acc act gac gaa aag ttc caa 1584Ser Thr Thr
Gly Glu Trp Asn Lys Leu Thr Thr Asp Glu Lys Phe Gln 515 520 525 gac
aac acc aga atc aga ttg atc gaa gtt atg ttg cca act atg gat 1632Asp
Asn Thr Arg Ile Arg Leu Ile Glu Val Met Leu Pro Thr Met Asp 530 535
540 gct cca tct aac ttg gtt aag caa gct caa ttg act gct gct acc aac
1680Ala Pro Ser Asn Leu Val Lys Gln Ala Gln Leu Thr Ala Ala Thr Asn
545 550 555 560 gct aag aac taa 1692Ala Lys Asn
124563PRTKluyveromyces lactis 124Met Ser Glu Ile Thr Leu Gly Arg
Tyr Leu Phe Glu Arg Leu Lys Gln 1 5 10 15 Val Glu Val Gln Thr Ile
Phe Gly Leu Pro Gly Asp Phe Asn Leu Ser 20 25 30 Leu Leu Asp Asn
Ile Tyr Glu Val Pro Gly Met Arg Trp Ala Gly Asn 35 40 45 Ala Asn
Glu Leu Asn Ala Ala Tyr Ala Ala Asp Gly Tyr Ala Arg Leu 50 55 60
Lys Gly Met Ser Cys Ile Ile Thr Thr Phe Gly Val Gly Glu Leu Ser 65
70 75 80 Ala Leu Asn Gly Ile Ala Gly Ser Tyr Ala Glu His Val Gly
Val Leu 85 90 95 His Val Val Gly Val Pro Ser Val Ser Ser Gln Ala
Lys Gln Leu Leu 100 105 110 Leu His His Thr Leu Gly Asn Gly Asp Phe
Thr Val Phe His Arg Met 115 120 125 Ser Ser Asn Ile Ser Glu Thr Thr
Ala Met Ile Thr Asp Ile Asn Thr 130 135 140 Ala Pro Ala Glu Ile Asp
Arg Cys Ile Arg Thr Thr Tyr Val Ser Gln 145 150 155 160 Arg Pro Val
Tyr Leu Gly Leu Pro Ala Asn Leu Val Asp Leu Thr Val 165 170 175 Pro
Ala Ser Leu Leu Asp Thr Pro Ile Asp Leu Ser Leu Lys Pro Asn 180 185
190 Asp Pro Glu Ala Glu Glu Glu Val Ile Glu Asn Val Leu Gln Leu Ile
195 200 205 Lys Glu Ala Lys Asn Pro Val Ile Leu Ala Asp Ala Cys Cys
Ser Arg 210 215 220 His Asp Ala Lys Ala Glu Thr Lys Lys Leu Ile Asp
Leu Thr Gln Phe 225 230 235 240 Pro Ala Phe Val Thr Pro Met Gly Lys
Gly Ser Ile Asp Glu Lys His 245 250 255 Pro Arg Phe Gly Gly Val Tyr
Val Gly Thr Leu Ser Ser Pro Ala Val 260 265 270 Lys Glu Ala Val Glu
Ser Ala Asp Leu Val Leu Ser Val Gly Ala Leu 275 280 285 Leu Ser Asp
Phe Asn Thr Gly Ser Phe Ser Tyr Ser Tyr Lys Thr Lys 290 295 300 Asn
Ile Val Glu Phe His Ser Asp Tyr Thr Lys Ile Arg Ser Ala Thr 305 310
315 320 Phe Pro Gly Val Gln Met Lys Phe Ala Leu Gln Lys Leu Leu Thr
Lys 325 330 335 Val Ala Asp Ala Ala Lys Gly Tyr Lys Pro Val Pro Val
Pro Ser Glu 340 345 350 Pro Glu His Asn Glu Ala Val Ala Asp Ser Thr
Pro Leu Lys Gln Glu 355 360 365 Trp Val Trp Thr Gln Val Gly Glu Phe
Leu Arg Glu Gly Asp Val Val 370 375 380 Ile Thr Glu Thr Gly Thr Ser
Ala Phe Gly Ile Asn Gln Thr His Phe 385 390 395 400 Pro Asn Asn Thr
Tyr Gly Ile Ser Gln Val Leu Trp Gly Ser Ile Gly 405 410 415 Phe Thr
Thr Gly Ala Thr Leu Gly Ala Ala Phe Ala Ala Glu Glu Ile 420 425 430
Asp Pro Lys Lys Arg Val Ile Leu Phe Ile Gly Asp Gly Ser Leu Gln 435
440 445 Leu Thr Val Gln Glu Ile Ser Thr Met Ile Arg Trp Gly Leu Lys
Pro 450 455 460 Tyr Leu Phe Val Leu Asn Asn Asp Gly Tyr Thr Ile Glu
Arg Leu Ile 465 470 475 480 His Gly Glu Thr Ala Gln Tyr Asn Cys Ile
Gln Asn Trp Gln His Leu 485 490 495 Glu Leu Leu Pro Thr Phe Gly Ala
Lys Asp Tyr Glu Ala Val Arg Val 500 505 510 Ser Thr Thr Gly Glu Trp
Asn Lys Leu Thr Thr Asp Glu Lys Phe Gln 515 520 525 Asp Asn Thr Arg
Ile Arg Leu Ile Glu Val Met Leu Pro Thr Met Asp 530 535 540 Ala Pro
Ser Asn Leu Val Lys Gln Ala Gln Leu Thr Ala Ala Thr Asn 545 550 555
560 Ala Lys Asn 1251716DNAYarrowia lipolyticaCDS(1)..(1716) 125atg
agc gac tcc gaa ccc caa atg gtc gac ctg ggc gac tat ctc ttt 48Met
Ser Asp Ser Glu Pro Gln Met Val Asp Leu Gly Asp Tyr Leu Phe 1 5 10
15 gcc cga ttc aag cag cta ggc gtg gac tcc gtc ttt gga gtg ccc ggc
96Ala Arg Phe Lys Gln Leu Gly Val Asp Ser Val Phe Gly Val Pro Gly
20 25 30 gac ttc aac ctc acc ctg ttg gac cac gtg tac aat gtc gac
atg cgg 144Asp Phe Asn Leu Thr Leu Leu Asp His Val Tyr Asn Val Asp
Met Arg 35 40 45 tgg gtt ggg aac aca aac gag ctg aat gcc ggc tac
tcg gcc gac ggc 192Trp Val Gly Asn Thr Asn Glu Leu Asn Ala Gly Tyr
Ser Ala Asp Gly 50 55 60 tac tcc cgg gtc aag cgg ctg gca tgt ctt
gtc acc acc ttt ggc gtg 240Tyr Ser Arg Val Lys Arg Leu Ala Cys Leu
Val Thr Thr Phe Gly Val 65 70 75 80 gga gag ctg tct gcc gtg gct gct
gtg gca ggc tcg tac gcc gag cat 288Gly Glu Leu Ser Ala Val Ala Ala
Val Ala Gly Ser Tyr Ala Glu His 85 90 95 gtg ggc gtg gtg cat gtt
gtg ggc gtt ccc agc acc tct gct gag aac 336Val Gly Val Val His Val
Val Gly Val Pro Ser Thr Ser Ala Glu Asn 100 105 110 aag cat ctg ctg
ctg cac cac aca ctc ggt aac ggc gac ttc cgg gtc 384Lys His Leu Leu
Leu His His Thr Leu Gly Asn Gly Asp Phe Arg Val 115 120 125 ttt gcc
cag atg tcc aaa ctc atc tcc gag tac acc cac cat att gag 432Phe Ala
Gln Met Ser Lys Leu Ile Ser Glu Tyr Thr His His Ile Glu 130 135 140
gac ccc agc gag gct gcc gac gta atc gac acc gcc atc cga atc gcc
480Asp Pro Ser Glu Ala Ala Asp Val Ile Asp Thr Ala Ile Arg Ile Ala
145 150 155 160 tac acc cac cag cgg ccc gtt tac att gct gtg ccc tcc
aac ttc tcc 528Tyr Thr His Gln Arg Pro Val Tyr Ile Ala Val Pro Ser
Asn Phe Ser 165 170 175 gag gtc gat att gcc gac cag gct aga ctg gat
acc ccc ctg gac ctt 576Glu Val Asp Ile Ala Asp Gln Ala Arg Leu Asp
Thr Pro Leu Asp Leu 180 185 190 tcg ctg cag ccc aac gac ccc gag agc
cag tac gag gtg att gag gag 624Ser Leu Gln Pro Asn Asp Pro Glu Ser
Gln Tyr Glu Val Ile Glu Glu 195 200 205 att tgc tcg cgt atc aag gcc
gcc aag aag ccc gtg att ctc gtc gac 672Ile Cys Ser Arg Ile Lys Ala
Ala Lys Lys Pro Val Ile Leu Val Asp 210 215 220 gcc tgc gct tcg cga
tac aga tgt gtg gac gag acc aag gag ctg gcc 720Ala Cys Ala Ser Arg
Tyr Arg Cys Val Asp Glu Thr Lys Glu Leu Ala 225 230 235 240 aag atc
acc aac ttt gcc tac ttt gtc act ccc atg ggt aag ggt tct 768Lys Ile
Thr Asn Phe Ala Tyr Phe Val Thr Pro Met Gly Lys Gly Ser 245 250 255
gtg gac gag gat act gac cgg tac gga gga aca tac gtc gga tcg ctg
816Val Asp Glu Asp Thr Asp Arg Tyr Gly Gly Thr Tyr Val Gly Ser Leu
260 265 270 act gct cct gct act gcc gag gtg gtt gag aca gct gat ctc
atc atc 864Thr Ala Pro Ala Thr Ala Glu Val Val Glu Thr Ala Asp Leu
Ile Ile 275 280 285 tcc gta gga gct ctt ctg tcg gac ttc aac acc ggt
tcc ttc tcg tac 912Ser Val Gly Ala Leu Leu Ser Asp Phe Asn Thr Gly
Ser Phe Ser Tyr 290 295 300 tcc tac tcc acc aaa aac gtg gtg gaa ttg
cat tcg gac cac gtc aaa 960Ser Tyr Ser Thr Lys Asn Val Val Glu Leu
His Ser Asp His Val Lys 305 310 315 320 atc aag tcc gcc acc tac aac
aac gtc ggc atg aaa atg ctg ttc ccg 1008Ile Lys Ser Ala Thr Tyr Asn
Asn Val Gly Met Lys Met Leu Phe Pro 325 330 335 ccc ctg ctc gaa gcc
gtc aag aaa ctg gtt gcc gag acc cct gac ttt 1056Pro Leu Leu Glu Ala
Val Lys Lys Leu Val Ala Glu Thr Pro Asp Phe 340
345 350 gca tcc aag gct ctg gct gtt ccc gac acc act ccc aag atc ccc
gag 1104Ala Ser Lys Ala Leu Ala Val Pro Asp Thr Thr Pro Lys Ile Pro
Glu 355 360 365 gta ccc gat gat cac att acg acc cag gca tgg ctg tgg
cag cgt ctc 1152Val Pro Asp Asp His Ile Thr Thr Gln Ala Trp Leu Trp
Gln Arg Leu 370 375 380 agt tac ttt ctg agg ccc acc gac atc gtg gtc
acc gag acc gga acc 1200Ser Tyr Phe Leu Arg Pro Thr Asp Ile Val Val
Thr Glu Thr Gly Thr 385 390 395 400 tcg tcc ttt gga atc atc cag acc
aag ttc ccc cac aac gtc cga ggt 1248Ser Ser Phe Gly Ile Ile Gln Thr
Lys Phe Pro His Asn Val Arg Gly 405 410 415 atc tcg cag gtg ctg tgg
ggc tct att gga tac tcg gtg gga gca gcc 1296Ile Ser Gln Val Leu Trp
Gly Ser Ile Gly Tyr Ser Val Gly Ala Ala 420 425 430 tgt gga gcc tcc
att gct gca cag gag att gac ccc cag cag cga gtg 1344Cys Gly Ala Ser
Ile Ala Ala Gln Glu Ile Asp Pro Gln Gln Arg Val 435 440 445 att ctg
ttt gtg ggc gac ggc tct ctt cag ctg acg gtg acc gag atc 1392Ile Leu
Phe Val Gly Asp Gly Ser Leu Gln Leu Thr Val Thr Glu Ile 450 455 460
tcg tgc atg atc cgc aac aac gtc aag ccg tac att ttt gtg ctc aac
1440Ser Cys Met Ile Arg Asn Asn Val Lys Pro Tyr Ile Phe Val Leu Asn
465 470 475 480 aac gac ggc tac acc atc gag agg ctc att cac ggc gaa
aac gcc tcg 1488Asn Asp Gly Tyr Thr Ile Glu Arg Leu Ile His Gly Glu
Asn Ala Ser 485 490 495 tac aac gat gtg cac atg tgg aag tac tcc aag
att ctc gac acg ttc 1536Tyr Asn Asp Val His Met Trp Lys Tyr Ser Lys
Ile Leu Asp Thr Phe 500 505 510 aac gcc aag gcc cac gag tcg att gtg
gtc aac acc aag ggc gag atg 1584Asn Ala Lys Ala His Glu Ser Ile Val
Val Asn Thr Lys Gly Glu Met 515 520 525 gac gct ctg ttc gac aac gaa
gag ttt gcc aag ccc gac aag atc cgg 1632Asp Ala Leu Phe Asp Asn Glu
Glu Phe Ala Lys Pro Asp Lys Ile Arg 530 535 540 ctc att gag gtc atg
tgc gac aag atg gac gcg cct gcc tcg ttg atc 1680Leu Ile Glu Val Met
Cys Asp Lys Met Asp Ala Pro Ala Ser Leu Ile 545 550 555 560 aag cag
gct gag ctc tct gcc aag acc aac gtt tag 1716Lys Gln Ala Glu Leu Ser
Ala Lys Thr Asn Val 565 570 126571PRTYarrowia lipolytica 126Met Ser
Asp Ser Glu Pro Gln Met Val Asp Leu Gly Asp Tyr Leu Phe 1 5 10 15
Ala Arg Phe Lys Gln Leu Gly Val Asp Ser Val Phe Gly Val Pro Gly 20
25 30 Asp Phe Asn Leu Thr Leu Leu Asp His Val Tyr Asn Val Asp Met
Arg 35 40 45 Trp Val Gly Asn Thr Asn Glu Leu Asn Ala Gly Tyr Ser
Ala Asp Gly 50 55 60 Tyr Ser Arg Val Lys Arg Leu Ala Cys Leu Val
Thr Thr Phe Gly Val 65 70 75 80 Gly Glu Leu Ser Ala Val Ala Ala Val
Ala Gly Ser Tyr Ala Glu His 85 90 95 Val Gly Val Val His Val Val
Gly Val Pro Ser Thr Ser Ala Glu Asn 100 105 110 Lys His Leu Leu Leu
His His Thr Leu Gly Asn Gly Asp Phe Arg Val 115 120 125 Phe Ala Gln
Met Ser Lys Leu Ile Ser Glu Tyr Thr His His Ile Glu 130 135 140 Asp
Pro Ser Glu Ala Ala Asp Val Ile Asp Thr Ala Ile Arg Ile Ala 145 150
155 160 Tyr Thr His Gln Arg Pro Val Tyr Ile Ala Val Pro Ser Asn Phe
Ser 165 170 175 Glu Val Asp Ile Ala Asp Gln Ala Arg Leu Asp Thr Pro
Leu Asp Leu 180 185 190 Ser Leu Gln Pro Asn Asp Pro Glu Ser Gln Tyr
Glu Val Ile Glu Glu 195 200 205 Ile Cys Ser Arg Ile Lys Ala Ala Lys
Lys Pro Val Ile Leu Val Asp 210 215 220 Ala Cys Ala Ser Arg Tyr Arg
Cys Val Asp Glu Thr Lys Glu Leu Ala 225 230 235 240 Lys Ile Thr Asn
Phe Ala Tyr Phe Val Thr Pro Met Gly Lys Gly Ser 245 250 255 Val Asp
Glu Asp Thr Asp Arg Tyr Gly Gly Thr Tyr Val Gly Ser Leu 260 265 270
Thr Ala Pro Ala Thr Ala Glu Val Val Glu Thr Ala Asp Leu Ile Ile 275
280 285 Ser Val Gly Ala Leu Leu Ser Asp Phe Asn Thr Gly Ser Phe Ser
Tyr 290 295 300 Ser Tyr Ser Thr Lys Asn Val Val Glu Leu His Ser Asp
His Val Lys 305 310 315 320 Ile Lys Ser Ala Thr Tyr Asn Asn Val Gly
Met Lys Met Leu Phe Pro 325 330 335 Pro Leu Leu Glu Ala Val Lys Lys
Leu Val Ala Glu Thr Pro Asp Phe 340 345 350 Ala Ser Lys Ala Leu Ala
Val Pro Asp Thr Thr Pro Lys Ile Pro Glu 355 360 365 Val Pro Asp Asp
His Ile Thr Thr Gln Ala Trp Leu Trp Gln Arg Leu 370 375 380 Ser Tyr
Phe Leu Arg Pro Thr Asp Ile Val Val Thr Glu Thr Gly Thr 385 390 395
400 Ser Ser Phe Gly Ile Ile Gln Thr Lys Phe Pro His Asn Val Arg Gly
405 410 415 Ile Ser Gln Val Leu Trp Gly Ser Ile Gly Tyr Ser Val Gly
Ala Ala 420 425 430 Cys Gly Ala Ser Ile Ala Ala Gln Glu Ile Asp Pro
Gln Gln Arg Val 435 440 445 Ile Leu Phe Val Gly Asp Gly Ser Leu Gln
Leu Thr Val Thr Glu Ile 450 455 460 Ser Cys Met Ile Arg Asn Asn Val
Lys Pro Tyr Ile Phe Val Leu Asn 465 470 475 480 Asn Asp Gly Tyr Thr
Ile Glu Arg Leu Ile His Gly Glu Asn Ala Ser 485 490 495 Tyr Asn Asp
Val His Met Trp Lys Tyr Ser Lys Ile Leu Asp Thr Phe 500 505 510 Asn
Ala Lys Ala His Glu Ser Ile Val Val Asn Thr Lys Gly Glu Met 515 520
525 Asp Ala Leu Phe Asp Asn Glu Glu Phe Ala Lys Pro Asp Lys Ile Arg
530 535 540 Leu Ile Glu Val Met Cys Asp Lys Met Asp Ala Pro Ala Ser
Leu Ile 545 550 555 560 Lys Gln Ala Glu Leu Ser Ala Lys Thr Asn Val
565 570 1271716DNASchizosaccharomyces pombeCDS(1)..(1716) 127atg
agt ggg gat att tta gtc ggt gaa tat cta ttc aaa agg ctt gaa 48Met
Ser Gly Asp Ile Leu Val Gly Glu Tyr Leu Phe Lys Arg Leu Glu 1 5 10
15 caa tta ggg gtc aag tcc att ctt ggt gtt cca gga gat ttc aat tta
96Gln Leu Gly Val Lys Ser Ile Leu Gly Val Pro Gly Asp Phe Asn Leu
20 25 30 gct cta ctt gac tta att gag aaa gtt gga gat gag aaa ttt
cgt tgg 144Ala Leu Leu Asp Leu Ile Glu Lys Val Gly Asp Glu Lys Phe
Arg Trp 35 40 45 gtt ggc aat acc aat gag ttg aat ggt gct tat gcc
gct gat ggt tat 192Val Gly Asn Thr Asn Glu Leu Asn Gly Ala Tyr Ala
Ala Asp Gly Tyr 50 55 60 gct cgt gtt aat ggt ctt tca gcc att gtt
aca acg ttc ggc gtg gga 240Ala Arg Val Asn Gly Leu Ser Ala Ile Val
Thr Thr Phe Gly Val Gly 65 70 75 80 gag ctt tcc gct att aat gga gtg
gca ggt tct tat gcg gag cat gtc 288Glu Leu Ser Ala Ile Asn Gly Val
Ala Gly Ser Tyr Ala Glu His Val 85 90 95 cca gta gtt cat att gtt
gga atg cct tcc aca aag gtg caa gat act 336Pro Val Val His Ile Val
Gly Met Pro Ser Thr Lys Val Gln Asp Thr 100 105 110 gga gct ttg ctt
cat cat act tta gga gat gga gac ttt cgc act ttc 384Gly Ala Leu Leu
His His Thr Leu Gly Asp Gly Asp Phe Arg Thr Phe 115 120 125 atg gat
atg ttt aag aaa gtt tct gcc tac agt ata atg atc gat aac 432Met Asp
Met Phe Lys Lys Val Ser Ala Tyr Ser Ile Met Ile Asp Asn 130 135 140
gga aac gat gca gct gaa aag atc gat gaa gcc ttg tcg att tgt tat
480Gly Asn Asp Ala Ala Glu Lys Ile Asp Glu Ala Leu Ser Ile Cys Tyr
145 150 155 160 aaa aag gct agg cct gtt tac att ggt att cct tct gat
gct ggc tac 528Lys Lys Ala Arg Pro Val Tyr Ile Gly Ile Pro Ser Asp
Ala Gly Tyr 165 170 175 ttc aaa gca tct tca tca aat ctt ggg aaa aga
cta aag ctc gag gag 576Phe Lys Ala Ser Ser Ser Asn Leu Gly Lys Arg
Leu Lys Leu Glu Glu 180 185 190 gat act aac gat cca gca gtt gag caa
gaa gtc atc aat cat atc tcg 624Asp Thr Asn Asp Pro Ala Val Glu Gln
Glu Val Ile Asn His Ile Ser 195 200 205 gaa atg gtt gtc aat gca aag
aaa cca gtg att tta att gac gct tgt 672Glu Met Val Val Asn Ala Lys
Lys Pro Val Ile Leu Ile Asp Ala Cys 210 215 220 gct gta aga cat cgt
gtc gtt cca gaa gta cat gag ctg att aaa ttg 720Ala Val Arg His Arg
Val Val Pro Glu Val His Glu Leu Ile Lys Leu 225 230 235 240 acc cat
ttc cct aca tat gta act ccc atg ggt aaa tct gca att gac 768Thr His
Phe Pro Thr Tyr Val Thr Pro Met Gly Lys Ser Ala Ile Asp 245 250 255
gaa act tcg caa ttt ttt gac ggc gtt tat gtt ggt tca att tca gat
816Glu Thr Ser Gln Phe Phe Asp Gly Val Tyr Val Gly Ser Ile Ser Asp
260 265 270 cct gaa gtt aaa gac aga att gaa tcc act gat ctg ttg cta
tcc atc 864Pro Glu Val Lys Asp Arg Ile Glu Ser Thr Asp Leu Leu Leu
Ser Ile 275 280 285 ggt gct ctc aaa tca gac ttt aac acg ggt tcc ttc
tct tac cac ctc 912Gly Ala Leu Lys Ser Asp Phe Asn Thr Gly Ser Phe
Ser Tyr His Leu 290 295 300 agc caa aag aat gcc gtt gag ttt cat tca
gac cac atg cgc att cga 960Ser Gln Lys Asn Ala Val Glu Phe His Ser
Asp His Met Arg Ile Arg 305 310 315 320 tat gct ctt tat cca aat gta
gcc atg aag tat att ctt cgc aaa ctg 1008Tyr Ala Leu Tyr Pro Asn Val
Ala Met Lys Tyr Ile Leu Arg Lys Leu 325 330 335 ttg aaa gta ctt gat
gct tct atg tgt cat tcc aag gct gct cct acc 1056Leu Lys Val Leu Asp
Ala Ser Met Cys His Ser Lys Ala Ala Pro Thr 340 345 350 att ggc tac
aac atc aag cct aag cat gcg gaa gga tat tct tcc aac 1104Ile Gly Tyr
Asn Ile Lys Pro Lys His Ala Glu Gly Tyr Ser Ser Asn 355 360 365 gag
att act cat tgc tgg ttt tgg cct aaa ttt agt gaa ttt ttg aag 1152Glu
Ile Thr His Cys Trp Phe Trp Pro Lys Phe Ser Glu Phe Leu Lys 370 375
380 ccc cga gat gtt ttg atc acc gag act gga act gca aac ttt ggt gtc
1200Pro Arg Asp Val Leu Ile Thr Glu Thr Gly Thr Ala Asn Phe Gly Val
385 390 395 400 ctt gat tgc agg ttt cca aag gat gta aca gcc att tcc
cag gta tta 1248Leu Asp Cys Arg Phe Pro Lys Asp Val Thr Ala Ile Ser
Gln Val Leu 405 410 415 tgg gga tct att gga tac tcc gtt ggt gca atg
ttt ggt gct gtt ttg 1296Trp Gly Ser Ile Gly Tyr Ser Val Gly Ala Met
Phe Gly Ala Val Leu 420 425 430 gcc gtc cac gat tct aaa gag ccc gat
cgt cgt acc att ctt gta gta 1344Ala Val His Asp Ser Lys Glu Pro Asp
Arg Arg Thr Ile Leu Val Val 435 440 445 ggt gat gga tcc tta caa ctg
acg att aca gag att tca acc tgc att 1392Gly Asp Gly Ser Leu Gln Leu
Thr Ile Thr Glu Ile Ser Thr Cys Ile 450 455 460 cgc cat aac ctc aaa
cca att att ttc ata att aac aac gac ggt tac 1440Arg His Asn Leu Lys
Pro Ile Ile Phe Ile Ile Asn Asn Asp Gly Tyr 465 470 475 480 acc att
gag cgt tta att cat ggt ttg cat gct agc tat aac gaa att 1488Thr Ile
Glu Arg Leu Ile His Gly Leu His Ala Ser Tyr Asn Glu Ile 485 490 495
aac act aaa tgg ggc tac caa cag att ccc aag ttt ttc gga gct gct
1536Asn Thr Lys Trp Gly Tyr Gln Gln Ile Pro Lys Phe Phe Gly Ala Ala
500 505 510 gaa aac cac ttc cgc act tac tgt gtt aaa act cct act gac
gtt gaa 1584Glu Asn His Phe Arg Thr Tyr Cys Val Lys Thr Pro Thr Asp
Val Glu 515 520 525 aag ttg ttt agc gac aag gag ttt gca aat gca gat
gtc att caa gta 1632Lys Leu Phe Ser Asp Lys Glu Phe Ala Asn Ala Asp
Val Ile Gln Val 530 535 540 gtt gag ctt gta atg cct atg ttg gat gca
cct cgt gtc cta gtt gag 1680Val Glu Leu Val Met Pro Met Leu Asp Ala
Pro Arg Val Leu Val Glu 545 550 555 560 caa gcc aag ttg acg tct aag
atc aat aag caa tga 1716Gln Ala Lys Leu Thr Ser Lys Ile Asn Lys Gln
565 570 128571PRTSchizosaccharomyces pombe 128Met Ser Gly Asp Ile
Leu Val Gly Glu Tyr Leu Phe Lys Arg Leu Glu 1 5 10 15 Gln Leu Gly
Val Lys Ser Ile Leu Gly Val Pro Gly Asp Phe Asn Leu 20 25 30 Ala
Leu Leu Asp Leu Ile Glu Lys Val Gly Asp Glu Lys Phe Arg Trp 35 40
45 Val Gly Asn Thr Asn Glu Leu Asn Gly Ala Tyr Ala Ala Asp Gly Tyr
50 55 60 Ala Arg Val Asn Gly Leu Ser Ala Ile Val Thr Thr Phe Gly
Val Gly 65 70 75 80 Glu Leu Ser Ala Ile Asn Gly Val Ala Gly Ser Tyr
Ala Glu His Val 85 90 95 Pro Val Val His Ile Val Gly Met Pro Ser
Thr Lys Val Gln Asp Thr 100 105 110 Gly Ala Leu Leu His His Thr Leu
Gly Asp Gly Asp Phe Arg Thr Phe 115 120 125 Met Asp Met Phe Lys Lys
Val Ser Ala Tyr Ser Ile Met Ile Asp Asn 130 135 140 Gly Asn Asp Ala
Ala Glu Lys Ile Asp Glu Ala Leu Ser Ile Cys Tyr 145 150 155 160 Lys
Lys Ala Arg Pro Val Tyr Ile Gly Ile Pro Ser Asp Ala Gly Tyr 165 170
175 Phe Lys Ala Ser Ser Ser Asn Leu Gly Lys Arg Leu Lys Leu Glu Glu
180 185 190 Asp Thr Asn Asp Pro Ala Val Glu Gln Glu Val Ile Asn His
Ile Ser 195 200 205 Glu Met Val Val Asn Ala Lys Lys Pro Val Ile Leu
Ile Asp Ala Cys 210 215 220 Ala Val Arg His Arg Val Val Pro Glu Val
His Glu Leu Ile Lys Leu 225 230 235 240 Thr His Phe Pro Thr Tyr Val
Thr Pro Met Gly Lys Ser Ala Ile Asp 245 250 255 Glu Thr Ser Gln Phe
Phe Asp Gly Val Tyr Val Gly Ser Ile Ser Asp 260 265 270 Pro Glu Val
Lys Asp Arg Ile Glu Ser Thr Asp Leu Leu Leu Ser Ile 275 280 285 Gly
Ala Leu Lys Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr His Leu 290 295
300 Ser Gln Lys Asn Ala Val Glu Phe His Ser Asp His Met Arg Ile Arg
305 310 315 320 Tyr Ala Leu Tyr Pro Asn Val Ala Met Lys Tyr Ile Leu
Arg Lys Leu 325 330
335 Leu Lys Val Leu Asp Ala Ser Met Cys His Ser Lys Ala Ala Pro Thr
340 345 350 Ile Gly Tyr Asn Ile Lys Pro Lys His Ala Glu Gly Tyr Ser
Ser Asn 355 360 365 Glu Ile Thr His Cys Trp Phe Trp Pro Lys Phe Ser
Glu Phe Leu Lys 370 375 380 Pro Arg Asp Val Leu Ile Thr Glu Thr Gly
Thr Ala Asn Phe Gly Val 385 390 395 400 Leu Asp Cys Arg Phe Pro Lys
Asp Val Thr Ala Ile Ser Gln Val Leu 405 410 415 Trp Gly Ser Ile Gly
Tyr Ser Val Gly Ala Met Phe Gly Ala Val Leu 420 425 430 Ala Val His
Asp Ser Lys Glu Pro Asp Arg Arg Thr Ile Leu Val Val 435 440 445 Gly
Asp Gly Ser Leu Gln Leu Thr Ile Thr Glu Ile Ser Thr Cys Ile 450 455
460 Arg His Asn Leu Lys Pro Ile Ile Phe Ile Ile Asn Asn Asp Gly Tyr
465 470 475 480 Thr Ile Glu Arg Leu Ile His Gly Leu His Ala Ser Tyr
Asn Glu Ile 485 490 495 Asn Thr Lys Trp Gly Tyr Gln Gln Ile Pro Lys
Phe Phe Gly Ala Ala 500 505 510 Glu Asn His Phe Arg Thr Tyr Cys Val
Lys Thr Pro Thr Asp Val Glu 515 520 525 Lys Leu Phe Ser Asp Lys Glu
Phe Ala Asn Ala Asp Val Ile Gln Val 530 535 540 Val Glu Leu Val Met
Pro Met Leu Asp Ala Pro Arg Val Leu Val Glu 545 550 555 560 Gln Ala
Lys Leu Thr Ser Lys Ile Asn Lys Gln 565 570
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