U.S. patent application number 14/881966 was filed with the patent office on 2016-09-15 for gene for identifying individuals with familial dysautonomia. The applicant listed for this patent is The General Hospital Corporation. Invention is credited to James F. Gusella, Susan Slaugenhaupt.
Application Number | 20160265052 14/881966 |
Document ID | / |
Family ID | 22987684 |
Filed Date | 2016-09-15 |
United States Patent Application | 20160265052 |
Kind Code | A1 |
Slaugenhaupt; Susan ; et al. | September 15, 2016 |
This invention relates to methods and compositions useful for detecting mutations which cause Familial Dysautonomia. Familial dysautonomia (FD; Riley-Day syndrome), an Ashkenazi Jewish disorder, is the best known and most frequent of a group of congenital sensory neuropathies and is characterized by widespread sensory and variable autonomic dysfunction. Previously, we mapped the FD gene, DYS, to a 0.5 cM region of chromosome 9q31 and showed that the ethnic bias is due to a founder effect, with >99.5% of disease alleles sharing a common ancestral haplotype. To investigate the molecular basis of FD, we sequenced the minimal candidate region and cloned and characterized its 5 genes. One of these, IKBKAP, harbors two mutations that can cause FD. The major haplotype mutation is located in the donor splice site of intron 20. This mutation can result in skipping of exon 20 in the mRNA from FD patients, although they continue to express varying levels of wild-type message in a tissue-specific manner. RNA isolated from patient lymphoblasts is primarily wild-type, whereas only the deleted message is seen in RNA isolated from brain. The mutation associated with the minor haplotype in four patients is a missense (R696P) mutation in exon 19 that is predicted to disrupt a potential phosphorylation site. Our findings indicate that almost all cases of FD are caused by an unusual splice defect that displays tissue-specific expression; and they also provide the basis for rapid carrier screening in the Ashkenazi Jewish population.
Inventors: | Slaugenhaupt; Susan; (Quincy, MA) ; Gusella; James F.; (Framingham, MA) | ||||||||||
Applicant: |
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Family ID: | 22987684 | ||||||||||
Appl. No.: | 14/881966 | ||||||||||
Filed: | October 13, 2015 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
13449981 | Apr 18, 2012 | |||
14881966 | ||||
12172847 | Jul 14, 2008 | |||
13449981 | ||||
10041856 | Jan 7, 2002 | 7388093 | ||
12172847 | ||||
60260080 | Jan 6, 2001 | |||
Current U.S. Class: | 1/1 |
Current CPC Class: | A01K 2217/075 20130101; A01K 2267/0318 20130101; A01K 2267/0306 20130101; A01K 2227/105 20130101; A01K 2217/05 20130101; C12Q 2600/156 20130101; C12N 15/8509 20130101; C07K 14/47 20130101; C12Q 1/6883 20130101 |
International Class: | C12Q 1/68 20060101 C12Q001/68 |
Sequence CWU 1
1
89166479DNAHomo sapiens 1ccagtgctgc ggctgcctag ttgacgcacc
cattgagtcg ctggcttctt tgcagcgctt 60cagcgttttc ccctggaggg cgcctccatc
cttggaggcc tagtgccgtc ggagagagag 120cgggagccgc ggacagagac
gcgtgcgcaa ttcggagccg actctgggtg cggactgtgg 180gagctgactc
tgggtagccg gctgcgcgtg gctggggagg cgaggccgga cgcacctctg
240tttgggggtc ctcaggtaag cgatccatcc agggtagggg cacgggagtg
gacctctccg 300ccggcggtgt ccgggtgaag gagacccgga gcctcctctg
cctgctgcgg gccggggact 360ggagtgcggg ctgcaccacc tctttcctag
agccttaaat tctttttgca gccttgccac 420ctgctccatc gggggcgctg
ggaggcgcga cagcccaggg atgcctgctg cccctccagc 480cggacttaac
ccagcctctt gattgcttgc agggggttga taataacgct gaaagcgaga
540gtattaattc acgatggaag gcggcggtta atagaggctc gggtgctgtg
gtgcgggtcc 600tttctcgcgt gtgagacttt ttcgtggagg tggtgtcctc
tgtgcttctc catctaacgt 660ggtgttttac gtggctttct ctcccgttaa
cgatgatctc cgtggagaca gtggctgagt 720aatcttcaga tcccagtact
tagcaagtgc tcagtcggtg ttggatgtag gccacaaacc 780ggatcgtaaa
gaattcaact gtatattgac agccacggaa ctaatcaatg aatagatccg
840tatgaagagt aagcaaaaag gcagcaaaga cagtttttca gcttggggac
atagagtaga 900aatggtctgt ccccaaatag tgggaactgt catttggggg
aagaatagca agttctttgc 960tttccaggtc gcatttgatg tgcatgtgag
acatgcttgt gattctatca ggaggttgaa 1020aatgtgggtt tagtggtaag
tttgggctaa ttcagtcagg gctaggcatt taggcctaat 1080cagcgtattg
gtgatctacc tggtatatgt aatcatgcat gtgatgtcta gccaagaggt
1140ggatagtcga aggagcaagg gaagaaaatg aagcagttat caggaaatta
agagagaatc 1200cacgattgac ctttggtgtg gagggatctt tagcacattt
aagaactgcg aagagtttga 1260atcagtggag gcaggaaggt tggaggttgc
agatgtccaa gaaagagtac taataggcct 1320aggtcctgtg gcaatatgga
ggatattcct ttcctagcct ggaaagaagt ggagggaagt 1380cttcctccga
gaagataagg gaataaggct gatgggtgtg aaatttcaga gaaactagtt
1440ttgaggcgtt tttatgatgt ttaaagatga aaaacgagca ggcacggtgg
ctcaggcctg 1500taatcccagc actttgggag gcagaggcgg gtggatcact
tgaggttagg agttcaagaa 1560cagcctgggc aacatggtga aaccctgtct
ctactaaaaa tacaaaaatt aactgggcat 1620ggtgccgggc gcctgtaatc
ccagctactc cggaggctga ggcaggagaa tcgcttgaac 1680ccggaaggca
gatgttgcgg tgagccgaga tcgcgccatt gcaccccagc ctgggcaata
1740agagcgaaac tccgtctcaa aaaacaaaaa aacctgcatg atatgttaga
ggttcaagta 1800atttctagca gttcttgaat ataattgtca ccaaaactta
ctaaaatcat tgtcttcctc 1860acttccatca tatataaact tacctttctc
ttatcccaca ttatatatta tataattcct 1920atgacacttg acattatctt
ctgtgtacta ttaggattga ttcatcttta ttctttctat 1980gtcatacata
tgtggggtgc caagatgaga gaagtctcct tggattaaag tgacaataag
2040accggtgtgg tccttgtaat tgctacccct aacataagtt agggacttac
aatcataagc 2100cttaaaggga tctgaatata aataactagc acagtaacat
ttttttcccc tacttaggta 2160atgttatgca tttaagcaag cctgattttg
ccagaccaaa gtagatgtct tgtttagcac 2220tcttttctca cgttttatat
tgtcctggga aaagcctggc cagaagaaca aagttactgg 2280aagtagttat
gtcaggtcat cagggtcctt gaaatgttgg tcatcatttt gaagtaaatt
2340gttgtcatgt cccagtattt tctcttcccc tttagaacag taaatgcttt
tctatctttg 2400atttcagttt ttttatgaat gtataaaacc agtttataaa
tgaatagacc tggtgaatat 2460taaagtcatt tcagattctc ttcaactgcc
agtatataaa aatggatttt caaatagtgc 2520taatcagtgg gatacccttt
tgtttttcct catgatttta taaagatgtc ctaatatgca 2580aaaataaaat
gtttccccat tcatttgttc tttcaacttt cccaaaggaa taactgatat
2640tacatctttt ttgaagaaaa cattctaaag ttgagaatct tgcctctcct
aaaaagaaca 2700taaaataggt ttcagaattc ctaatttgta gaccataact
gtatagagtg ggtcaggttg 2760ctgctataat ccatacatgg gtgtgtactc
agagaggtaa gttttttctt ttcttggtta 2820ttctgattct gactaccact
tcttcacccc ctgaatcatt tcatttaaat aaatatggtc 2880atttatcact
attaagctat ttatttttct cttagagatt aatgattcat caagggatag
2940ttgtacttgt ctcgtgggaa tcacttcatc atgcgaaatc tgaaattatt
tcggaccctg 3000gagttcaggg atattcaagg tccagggaat cctcagtgct
tctctctccg aactgaacag 3060gggacggtgc tcattggttc agaacatggc
ctgatagaag tagaccctgt ctcaagagaa 3120gtaagttact gatgtagaat
gccagcatgt gggtatgacc cttgatttct cttcttccaa 3180atttctttcc
ccacatggtc tttctttata tcttattgaa tttatatcct cccaaataaa
3240catcttttgc ttcatatata tgccatgtta gacatagctt aaatcgtaat
ccttctttaa 3300ctctgctgct attttaacct aagtcagtag aactctgacc
ttactttttg agtgtgtgcc 3360gtacttttta ccctctttgt catgcaaatt
ctgtttataa gagtggtttt tttttttttt 3420tttttgagac ggagtctcgc
tctgtcaccc aggctggagt gcagtggtgt gatcgtggct 3480cactgcaagc
tccgcctccc cgggttcaca ccattctcct gcctcagcct cccgagaagc
3540tgggactaca ggcgcccgcc accgcgcccg gctaattttt tgtattttta
gtagatgtgc 3600ggtttcaccg tgttagccag gatggtcttg atctcctgac
ctcgtgatcc gcctgcctca 3660gcgcccggcc aagagtggtt tttaattggg
aatgaacacg aaagttgccc atggagcttt 3720ctaaaagttt gagcccacat
ctcatgtcaa ctaaatcaga atctttagtg ttggctccta 3780actatatgta
ctttaaaaac ctctgtgggt tggttttgat atggtccctt gattatgttc
3840ttctactaat acattttagg cagttacatc ctttagtgcc ttttccccat
actatagaaa 3900tcttagaaaa gcatagctat tagcatcata ttttagtgga
caattttaaa gagaccaggc 3960ttattgtttt tgtttttgtg tttgtttggc
aaaaaggtca cattacctat ttttcttgtt 4020agagatgaca gagtagtgat
atttctcaaa tgaaagtttg gattttcatc tagaaaaaat 4080atttttgaaa
gcttttatgt aataaaagaa gcattaaaaa gtatttctgg aaatgttatc
4140aattattctt gaaagtagac tgggttaatt tgcttgtgtt tactttggtg
aaaggtgaaa 4200aatgaagttt ctttggtggc agaaggcttt ctcccagagg
atggaagtgg ccgcattgtt 4260ggtgttcagg acttgctgga tcaggagtct
gtgtgtgtgg ccacagcctc tggagacgtc 4320atactctgca gtctcagcac
acaacaggta agtggaagac tccagtgagg ggggagtctc 4380aagcatcctc
aaataggtta cttgctattt gtggaagttt tcaaatcagt agccataata
4440gttacacttt tgctaattaa tttttgcatt atatatttct ttatttaaaa
aattgttaac 4500atggctttat ctatatgtta agattcttct aaaactgagt
tttgtctgct gcatctatta 4560atcagagtga tcagaatgtt ccaaatgaga
atatattttt ttaaaagtta aaactggcta 4620ttcttatgtg gtgtagatca
cctcttatca gaccctcatc ttgagttgca acctttgttt 4680ctcaatttag
gaagtctttg tttatctgac ttagattttc tgttatgaat gttgattggc
4740taaatttaga gtccctgaag tctaggcact aaagtaaata cattgtcatt
acctgcacat 4800gtgatgactg ccagtagagc tagacttcaa gcaattgctt
ctttctctac tttagtgtat 4860agttgagttt ctgatttcta tcctcacctt
cttaacagca agggtttcaa attacacttg 4920gctgattctt taaatcttct
tccattactt cattagttgt gatctcctta acattgatta 4980tgtcacagaa
gttagagtat tactaatagt aggataatga tagcagctta catttattaa
5040ctatcatgtg cctggcactt tttaaagtgc ttttcatgca aatttattta
atcttcacca 5100tgaccttatg cagtaggttg ttgtttccta ttcttcagaa
gaggcagtta aggcacagag 5160tgcttaagta attagaccag ggtcacacag
taatcaaatg gggtttgacc ctagcagtct 5220aaatctggca cctctgctct
taaccattcc atttagtaca atcataaacc tttacttgca 5280gttcatggtg
ggaaatatca aacttgtcat atacagcttg tttttttttc gtatttgaaa
5340gatagatgct tttactttcc aaacattttg tagcattgtt tcctggttac
tgagctcttc 5400cagtctattt atcttcattt aatggtgctg attctgccct
ttagtggctt ctcaattgtc 5460tgaaaggtag agcccactat tgtgccttat
aagccccttt cactatctgt tccccacatt 5520cctttttagc ctcatccccc
cattgttcct gtgtgtacgt aaaccttatg ttttagttgc 5580agctgatttt
taactgctct tttttctggc tttgtgcctc tacactgtgt tttcttcctg
5640gtctctcttt cctgtcctta ttaccactct ttgaaacacg tcagaaaaac
tttttctgga 5700ctttgggcca cttgtcattc cctgtgctga gacgcatttt
gctttccaga gatcttggtc 5760attgctgtta tcctctgtag ggtcttcttt
tatctccctc gtgagacagc tctgggaaga 5820aaaagatatt tatttctaat
ccctgtgcct aataacaggt ctattctctt gatatccatt 5880actgaagaaa
tgtttgttga gtaagttctt gttttaattt ttaaatataa atttttaatt
5940tttatgagta catagtaggt acatatattt atgggctaca tgagatgttc
tgatacaggc 6000atgcagtgca aaataaccac atcatggaga ataggatatc
catcccatca agcgtttatc 6060ctttgtgtta caaacaatcc aattacagtc
ttttagttat tttaaaatgt gcaattactg 6120ttgactgtag ttaccttgtt
gtgctatcaa atagcaggtc ttatttattc tatttttttt 6180tgtacctatt
aaccatccca acttccctca gcccctcact acccttccca gcctctggta
6240accatccttg tactctctgt gtccgtgagt tcaattgttt tgatttttag
atcgcacaaa 6300taagtgagaa catgtgatgt ttgtcttttt gtgtctggtt
tatttcactt aatgtaatca 6360tctccagttc catctatgtt gttgcagatg
acaggatctt attctttttt tatggctgaa 6420tagtactcca ttgtgtatag
taccacaatt tctttatcca gtcatccatt gatggacact 6480taggttgctt
ccaaatctta gctattgtga acagagctgc aacaaacatg agagtgcaga
6540tatctcttcc atatactgat gtcttttcgt tttgtttttt taattgtttt
gattgaagtt 6600gcagtcagtt tttactgaga tgctagtgtt tgaatctctc
ttttcaattt tctctgtctc 6660agctggagtg tgttgggagt gtagccagtg
gtatctctgt tatgagttgg agtcctgacc 6720aagagctggt gcttcttgcc
acaggtaagc ttgttactgg tgcctcactg gcttttttaa 6780aacattattc
cagatgtctt acaggcttca tcagctttag gctgcttgaa tttcaaaaaa
6840tttctttgaa ccagtataat accaattatg aaccagtata ataccaatta
tgtatgtgtg 6900tgtgtatata tatataaaac gtagagtgat ttttttttgg
tgactgaagt tttgcctctt 6960agtctatcat tataaaaagt tgtttcatgt
aactttttaa gtctttggga gtaagaaaca 7020aagtcataaa acttggggag
gctgctaagt ccccagttag agttaaaaat gtcagcaata 7080tgtattttaa
cttattctaa gagttgctgt atggacacat tctaaaagcc cttcttgggt
7140tctgttgctg tttttcccct ttaagtctca tcattccaga tgagtttagt
aaaccagctc 7200cactgatgac atttatattt agaggtatct tggggacaag
gagtgttgaa gttagtggag 7260gagggctttg tggactttta agttcaactg
tacacacatt aatagctgag cataagcacc 7320aggtgactta tctagggaaa
gctttttggg gttttttgtc attgttgttt ttttaagtca 7380aagcattttg
gatgaattct gtctgctctg ttcagactaa ctccagctcc ttagcttaca
7440gtgccatagg tacttaggaa tggcaaattt gttacatgaa aacaaaatca
tttttgtttg 7500tgtttctcta aggtcaacag accctgatta tgatgacaaa
agattttgag ccaatcctgg 7560agcagcagat ccatcaggat gattttggtg
aaagtaagta tagctttgtg caatattttg 7620tgacctacgt ttcttcccat
ttttgaccat ttccttgtgc actaatagcc atgtcattag 7680gccaaagaac
tgtgaaagtt aaacccccag ctattaaatg tctattagcc cagttccttc
7740agcccatccc aaatcttaaa aggcctactg atgcctctcc aggtctgagg
gtttaaggtc 7800acttagatag ttattaccca aaccctagga aagtcttagg
ctgggctttc agtgaaaggg 7860actgtacaag gtagtatttc tgggatacag
ttttagggag aagaaaagaa gaaagatgga 7920atagaaggct ggtttttgtt
actacgatta gatccaatct gcatttccat gggaacaatc 7980agattatttt
cttgctaaaa tctagccaag gtcatctggg cattaaggct gtgggggtat
8040tgaagggcag tgcaggagaa gagagacgct tattaagcat aagctttggc
catcttgaag 8100tcacaaagta gctggcctga ttgaagaggg atggggaaga
agatgttcca acttctgtta 8160tggtctaact tcctgccttc ttgctccatc
aactctgaga aatcatttag acaacttcta 8220cccatttatt tacaaataat
gtatttgttc agaaataatt ttggagggct gggcacagtg 8280gctcatgcct
gtaatcccag cacttttgga ggatgaggca ggaggattgc ttgagcccag
8340gagtttgata ctagcctagg caacgtaggg agacccagca tctacaaaga
atttaaaaat 8400tagctgggct tggtggtatc agcacagtaa tgacatgatg
tgcaggtact ggggtagcat 8460aagggaagga aacgagtaac tagagaggga
tgatttattt cccctaggag gccaacttga 8520gctgagtctc agctgaattg
gtgttgggta ggtgagggat aagggtgggg agtagtcagc 8580tgaattggta
ttgggcaggt gagggataag ggtttggagt agtcagctga attggtattg
8640ggtaggtgag ggataagggt ggggaacagt ccaagcaagt gaatgtgtcc
atttcaagtg 8700tccatttcaa gggagggtta tttcatagaa acattgtggg
ttactcaggg aactgtgagt 8760aattcagcat tgctgaagtg gcagaatgtg
agtgtagaat gaaataaatg gaacagattt 8820gattgagttt gtagtaggga
atatggacat tgagttatag ttgatcagcc attacaagtt 8880ttgatgataa
gaggtttaaa gagatttatt taatagaaag atggctcgtg atggcatatt
8940tttgttgttt ttgtgtgtgg agagggaaga gatgagaggc agggtgatca
ggtaggaggt 9000tgctacagga atccagatga aagataagga aggtttgtgt
ggggctagaa gcaggaatca 9060ttcaggaaaa aacttgattc acaatgagga
tgggagtaca ttttttagaa ttagctggga 9120aactttttta gaatatatgt
gcatgattcc ccttctgccc taggccagtt tgagaaatac 9180caatttagaa
agtgaaataa ataggctttg cgtatgtaag gtgaataaga aaaagttgag
9240caggactcca gccagaacct caggtgttgg gaataaagat gccagtaaca
gggaagatgg 9300agaagtgctg gtctgtaagg ggtgggtggt gagatctgtt
ttggatttgt tgaaggacca 9360tatgtgattg ccatgtggag tatgcaaata
taaggctgaa gctcaggaga ggccagagct 9420atggactgag agtagtgggt
atgtaggaaa ttctgacagt tttgggaaca gatggactgt 9480ctcagggagc
agatgctgta caggaagagt ctagaatcca gggtggaact ctggggcatc
9540cagctttgag gacagtcaga gagagagtaa cagcacacag tatactttgg
gatgggaaag 9600tgctctgggc ctggtgtttc ccactgactt tttcacacaa
atcctaatgc agtaaatcaa 9660aggaaatgta ggccaagtta agatcttagg
tctcagaaat gtgtttctca gtacaaaaaa 9720aaaaaaatca ttctatggag
tgatgaatat ttttcctcta tcctggggtc agtagacttg 9780ttctgaaaag
ggctaggtca tgaatatgtt cagctttgca ggctgtatga tctgtgttgc
9840agctgctcaa ttctaatgtt gaggtgtgaa agttatacat gatacataag
cacatctatg 9900ttccagtaaa cgtttgtttg taaaagcaga tgtaggctgt
agttttgcaa atccctgctg 9960taaccccatc atttcttgtc ttccattgga
aaagttctct ttcttcattc cttggtcctt 10020aatctttctg tggaaacttg
cagatagaag cctgggggtt tgcaccagga tagtcactac 10080catttgtacg
cagcagcaat tgaggtactg tagcacttgg atgtgagcag acaggaaatg
10140gtcatatgga cccataattt ataggaattg caaacagccc tgcttcatca
gaatcagaat 10200caatggcagg aggaaagtat tgggtcctgg attaggtgat
gttttcagga ccatctttat 10260tgtgcttctt gcaaatggat cctacctcca
ggaacagaag ggttgtgttg tttcagcaac 10320tctgcctaat agtttatata
agagaagtgt tacgatctag aaagaacccc agtcagcctg 10380gaaggcagaa
gacctgtgtt ctactttttg gctccaccat tagggagggt ctcaatctct
10440aagtctatgt gaggagctgt tttgtgacct gcagcccctc tatcaccagt
gagagcttgc 10500aatcagaatt ttattcccag ttctcatctt ggggttttat
gttccggaca tattttgtaa 10560actctttatg tttcattctt cttacttata
aggtgagggt gagatcgctg acttgtgtca 10620tcaaagaaac ttggaatatg
taagatggca gtaaaatgct ttccaaaata aggaagggca 10680tttcaaattc
ttcaaagtca ctgctgcata taatatgaaa tgggttttgt ttgtttgttt
10740tgagatgggg gtctcgctgt gttacccagg ctagagagtg cagtagtaca
atcagggctc 10800actgcagcct tgaactcctg ggttcaagtg atcctcctac
tttagtctct tgagtagctg 10860ggaccacagg tgtgtgccat catgtccagc
ttattttgta tactttttgt agagatgggt 10920gtctccctat gttgcccagg
ctggtctcga actcctggac tcaagtgatc ctcctgcctc 10980agcctcccaa
agtgttggga ctataggcat gagccaccat gcccagcctg aaacataggt
11040ttctcaaata ttgactgctg gtcaatttat tgagaggcgt tagaggacct
gagtaattgc 11100caatgactaa cttcatgaag aatagcagtg aaactgtttt
tgtttcattt catgtggctt 11160attagttgtc ttgccaattg ttctgtaggc
aagtttatca ctgttggatg gggtaggaag 11220gagacacagt tccatggatc
agaaggcaga caagcagctt ttcagatgca aatggtaagt 11280ttggtttgat
ggataaaaag ccttgactgg aacaaatgta agtttgccac ccaccaggaa
11340ctctttggtg tccacttaga tgccagtaat gaacagttct cttctgcttt
agtaaaactg 11400cctagaacct tcaggaaatg aatccctcta gaaagatcct
ttttttcctt gttattgcca 11460agttgctttg tgatttattt tcatagtagc
aaataattat aaccaatatt catcacccag 11520tttaaaaaat aaaacatcac
agacaaagga aaccccctgt gtatcccgtc ccgatgtccc 11580tccccttcct
ctccagagag agctgccatc cttcattcac atgcatgttc tcatactttt
11640cccatatatg tgtatattag atatttttct ttttctgttg gatgaaactc
tttgttttcc 11700ttacttctgg attggaaaat tctgaagacc atataatgat
gtcttgatga ctcaaggcag 11760gactttttaa tcttctaatg taggcggggc
ggcccctgaa ggcagaggtg tgtggacaca 11820agaagagtgc agactcttgg
ggcacctggg gaagtagtgt ccgtgtcaca ttaaattcat 11880ttaaactctt
atattttatt ttaatttata caatatgaat attttttaaa actatgaatt
11940gaaaagtatt acccttgagt aaaattaatg ccccaagaag atgtgccata
tttaccctct 12000ggcacactac caagtacccc caggggcatt acagatctct
gttagaaaag tacagattac 12060attatcctca taacatttag aagctatgag
accttggcag ggaagtttcc taatgtttct 12120gagcctcagt attctctgta
aagtggacaa cataatgtct ccttacaagg gttgagatgg 12180gcaggtaata
gcatatataa aacagctatc atagcatcag cacagtgtag gcactcaaat
12240ggtagttgct gcttttgttt tagtagacaa ataatttttg aaacttttta
aagcgtagtt 12300tttatttcaa aacaacttta ttgtgagtaa aatatgcata
gtgggtctaa tttaacattc 12360tgaaagctat tgacttatta gaacagtaaa
ggattattag agggcagaaa catggagtaa 12420gtactctgag acacaacctt
gcttctttgg gggtgatcca ctacaactgc ccagctttgg 12480acaagtggtt
ttcatgttcc cctgattttt aagtgatttt tttttttttt ggcaggactt
12540aaaaggtatc cttgactaaa caggaacttg accaagtaaa tagttggtgc
aatttgaata 12600ttctttcttg ctataagcaa caagtaaatt atggtacagc
tttctaagac catatctttt 12660cgatttaaaa atagcacttt actcatacat
gttatgacat gggtaaacct cataaagatt 12720atgctaagtg aaagaagcca
gtcataaaag atcacatata atatgatccc atttgtatga 12780agtgcccaga
aggggcaaat ccacagaggc agaaagtaga gtagtggttg ggtagggctg
12840tggggtgggg tggggaaggg gtgactgcta atggatatgg ggtttctttt
ggggatgatg 12900aaaatgctca aaatttagat tatggtgatg gctattcaac
tttgtaaata tactttaaaa 12960acattgattc ttaccactga gtttaaacaa
ccaaaaaaaa atcccaaggt gcattgaatt 13020gtgtacttca aatgggtgaa
ccttaataat atgtaaatta tatcccagta aaggtgttaa 13080aaaatagtac
tttaaaggaa tctatggtag ttttgaaaat aaggcagttt tccatacttt
13140gttaaactct ggagaagatg acactttact actggtacct gctagagtaa
gacttatcta 13200gtattaacaa aattagggtt tattaatggt ataggatgat
ccaggtaatg ggggaaaaaa 13260accgagcatc ctgttatcta atgtactatc
cagtaaacta ctctagcttt ttttcatgaa 13320ctttttctaa aggctttcta
gggcctcgtc ttggtttgaa agttcacagc tacccttcag 13380aaaagaaaac
aaaaatccat ggagtaggca gatacaagta ctcatgtgag cataatttac
13440tttgattttt taagttgtgt tattctagcc ctcagcctgt tccctgcctg
ggctctccta 13500gtgcccagta acactgattc aagaggttgc atttagctgg
gcacagtggc tgatgcctgc 13560aatcccagca ctttgggagg ccaagttggg
cagatcacct gaggtcagga gttcaagacc 13620agcatgtcca acatggtgaa
atcctatctc tactaaaaat acaaaaatta gccaggcatg 13680gtggcagatg
cctgtaatct cagctacttg agaagctaag gtagtagaat cacttgtacc
13740tgggaggcag aggttgcggt gagccaagat tgtgccactg cactccagcc
tgggccataa 13800agcaagactc cgtctcaaaa aaaaaaaaaa aaaaattggg
tgagagggag gaattgagga 13860ggataccaag ggttgggcct gaacaaatgg
aagcataatt atatgtagaa atttctatga 13920gctactcttc tagaatagat
gactcaataa taccctgctt gccatctacg ttttctgtcc 13980ttaattattt
ccagttctat ttcatataat gcctatttca ggccttaacc cttcagtaaa
14040ggaggtttgg tttctatacc ctaggacagt ttcattgaga ataaattttg
ttaggctacc 14100tatgtattcc ctactgtgca gactacagta cagtactagc
agaattctta ggctgttact 14160agaatatgat gatgaatgcc cgggtggtca
tctgtctccc acccggtaga gttggcttca 14220ggattgagat acacgtggcc
ctggaggaga cgtttcttcc cgtcatgctg cagaatgaga 14280acatttccat
gttttcgtca ttgtctgctg ctgcctttac cacctctgtg gctcctccct
14340attcaccttg ttcacatctt aactcatctg tgccctgttg tgaagcttac
acaatatgta 14400aacaaaactc taccctgttg gacaaatgga acacttgttt
ccttgttgta gttacctgat 14460aggttcctta gctcattata ttcaggatct
agatctgtag ctcttttcct cttttgctgt 14520tctcagaggc cacttttttt
ttttttaatg ccgaaaggag gattttgttt gttttacatt 14580tttttcttct
ttttgatgat ttctgcgttc taagaaccaa cccttggatg gtttctgatt
14640ctagaggcag gctttcaaag tagcttaaac ctcttaaaaa acatctgtat
ctagtggtct 14700gaggcttgtt tgattctggg atacttaagg tcccccagta
atattggtgt ttgttcccct 14760ttttagcatg agtctgcttt gccctgggat
gaccatagac cacaagttac ctggcggggg 14820gatggacagt tttttgctgt
gagtgttgtt tgcccagaaa caggtatgga aatatattgc 14880agttaaacaa
caataaaaaa tttttatctt attaaaatta aggaaaattt tctttctttt
14940gctttgagta gggtattaat tatacatatg aggcaaggat gtgctgcttt
aaatgtgaaa 15000tgaggttaga gttaagaatt agaagagtcc tttgaggcca
tttggtccat cctcctacct 15060ggtggacaca aatttgtaac aaaattaatc
taattggcta tgtaaaacca tggcagtttt 15120tatttgtaag gaaggtgttt
gaatagttct gaattgacaa cttttatcat aatgttttaa 15180gtgtgtatgt
gtgtttgact ccactcccgc acaggggctc ggaaggtcag agtgtggaac
15240cgagagtttg ctttgcagtc aaccagtgag cctgtggcag gactgggacc
agccctggct 15300tggaagtgag tgggagaaga aaccttagag aaattcttgg
aaccagagta gaggtggtgg 15360tacacatgga tacagatgat acagatgttt
gtgtaacaca aaaggatttt tacgtttctt 15420catttggtta taaggctgta
tctatctttg tttcttcttt tttttttttc ttattccctg 15480aagtctgaat
tcaactcgaa tagtagattt tacgcttctt cacagatttc attgttccaa
15540ggccgcatat attttgcatt cctaactctt aaaaggctgt ggttttaagg
cagggtatat 15600atgaagccat tgtacagagc agaaaatggt gtttagaagg
gaaggcccag tttgcaaggc 15660tctgtggggc aaatggtgct tttgtggaaa
ttagggaaag agcctccttc cttggcacaa 15720aattcctaca gcagaggatc
tgcttgccaa ggagcatgca ggctggattc agaccctgct 15780ctttccttcc
attctcctcc ttggcccagt acccttgtgc aggttacaat ttgcctgtca
15840tatgtggctg cctgatttta gatagaagat gtatctcctc tgtttcggtg
atatctgttg 15900tatgtagacc tcttgtttcc caccagtatc tgaatggtat
tatatgatag agcagaagag 15960aaatgtattt gaattaaaac cctagagaca
aatatgaata agatgaggca attaagatgt 16020tttcaacatt tggtgaagtc
ttaaaaaaga cctactggag catagaatat ttgctgaagt 16080tgtataatgg
aaggagaaat agattttgat ttttaggaca ttatacctgg aatggtttag
16140ataacttatt atttttaaag tcatccaaat gcaatgtaaa tatgtaaggt
tttgtgggca 16200aatggagcct ctgtgtaaaa caggaaaagg cactctttcc
tctgggcaag tacagtccca 16260cagtgggatg aaccgctcgc cgagagacaa
gggacacatg ggatttaaaa cttccttgga 16320taaagatatt cattaattcg
ttcattcatt cattcatgtt tgctggaaaa aaaactcttc 16380tggattttat
ctattcttta gttaggtgag ctttcgatat tgtaacactc tgagtttgct
16440ttaagaccct caggcagttt gattgcatct acacaagata aacccaacca
gcaggatatt 16500gtgttttttg agaaaaatgg actccttcat ggacacttta
cacttccctt ccttaaagat 16560gaggttaagg taagtgcctg agtttgtttc
accctcgaat gtagaggact ttccatagct 16620atagagggaa tttttttttt
ttttttttga gatggagttt cattcttgtt gcccaggttg 16680gagtgcgata
gtgcaatctc ggttcactgc aacctccgcc tcctaggttc aagtgattct
16740cctgcctcag cctcccgagt agctgggatt acaggcttgc gccaccacag
ccagctaatt 16800ttgtattttt agtagagacg gggtttctcc gtgttggtca
ggctggtctc aaacccctga 16860cctcaggtga tccacccgcc tctgcctccc
aaagtgctgg gattacaggc gtgagccacc 16920acgcctggcc tatagagggg
atttatattt gatatggata tataaatagt agctttagag 16980taaatagtaa
taaaaatggt ggcttcctag aactgatttt tatttaataa aatattgttt
17040ttccagtgat tttgcaaata atagcatttg tcccccacct tagataaaac
agaagtagga 17100aataaaaatg ctagttttta ttgtttattt tgacaaaagc
ataatttttc cagtaatgaa 17160gatgtttttc atttataaca tttaaatctt
aagtggtttg tataccatta agattcttgc 17220tgaagtgaga acacatcaaa
tggtatctct gtgtaaaatt ttaaacatcc taagttgaga 17280gacgagttta
atgaactccc atgtaactat tactcacttt cagtagatac caacattttg
17340caaaactatt ttcatcggtc cgcaactctt tggcctatac atatatatac
ttacatatat 17400ttttatttcc tggagtttta attctagaaa tcatattttc
aatatttatt tataacagtt 17460aaggacattt ttctttacat aaccataatt
ctattattac atcttatctc tgtgttgtct 17520aacacccagt ccatattcca
gtttctctga ttgtctaaaa atgtcacctt gtatttggtt 17580aagtttctta
agtctctttt aatctttaag cataatgtat ttcttttttt taagtcctct
17640acataataat gacatatttt acagatttgt ttaatgcctc tgtaggttag
tgatttacag 17700ctagggatga gctcaggtag tgggattatt tgatttgaga
gaggaaatac agctattata 17760aagatttgga agtaaatcca taactgaaag
ccaatgacag atcttttttc ccttctaggt 17820aaatgacttg ctctggaatg
cagattcctc tgtgcttgca gtctggctgg aagaccttca 17880gagagaagaa
agctccattc cgaaaacctg tggtaagaca gctgtagtac cccagccttc
17940tgccccataa aacgtagttg aaagtagaca ggtatgggat ttccttcatc
ccttctactt 18000agtcccttag tagaatcaaa gatgctgaag tgggtaggtg
gaaatggggg tggttaggtt 18060ttgattgatt gtggatttca gtcatgtatt
ggttggggtt ctctagagaa acaaataata 18120catatatata attcgtccct
cagtattctc gggggattag ttctaggatt gcccatggac 18180gccaaaatcc
acacatggtc aagtcctgca gtcaaccctg cagaacactc agatatgaaa
18240agtcagcctt ttgtatactt gggttttgca ttcctcaagt accatatttt
tgatgtgcgt 18300ttggttgcgg gtatagaatc cacaatatga agggccgact
gtattcattg aaaaaaatac 18360gaatataaat ggacctgtgt agttcaagcc
tgtgttgttc aagggtcagc tgtacttaca 18420tagagagacg gtgagagagg
gaatagggtg gggcgggagg gagagagagt aatagagtgt 18480ggatagattt
actttaaaag attagctaat gtaggggatg gcaagtttga aatttgtggg
18540ggcaggttgg caggctggaa attcaggtaa gaattgatgt tgctgtcttg
agtatgaaat 18600ctgtagggca ggctggaaac ttagggagga tttctgttac
agccttaagg cagaatttct 18660tcttttctgc gaagcctcag tttttgcttt
taaggtcttc agctgaatga atgggacctt 18720cccacattat ggggaataat
ctgctttcct tatagtcagc cgattataaa tattaatcac 18780atctacagaa
taccttcaca gcaacatctg gagtttagca gatagctggg tgccatagcc
18840tagccaactt gacacaataa aattaactgt tgtaagtcat cacgtgcttt
ccctagtgca 18900tggtattacc acagaaaaaa cactaaccaa aggaattctg
tggacgtgaa agaagattta 18960gattaagcgt aaaagtaaga atatttttat
agcttttaaa atgtataagt gtgtggtttt 19020aagtattaaa taatacttga
aaatgttaga aaataagatg agaaaaaaat ctcatagttc 19080taccacttcg
taataatcac tattcaaatt ttcttgtctt ctaggttttt catgtatata
19140tctcagtata gctatcatct tgtttttgtt aaaagtgtag taggtatggg
ccaggtgcgg 19200tggctcatgc actttggggg cccagcactt tgggaggccg
aggcgggcgg atcacgaggt 19260caggagatcg agaccgtcct ggctaacacg
gtgtaacccc atctctacta aaaatacaaa 19320aaattagctg ggcgtggtgg
caggcgcctg tagtcccagc tactcaggag gctgaggcag 19380gagaatggtg
tgaacctgga ggaggcggag cttgcagtga atggagatcg tgccactgca
19440ctccagcctt ggcgacagag tgagactgtc tcaaaacaaa acaaaaaaaa
gtgtaggtgt 19500gatacatctg catcatttta aattgctgta taatactcgt
ttattctcgt tcattaaatc 19560tcatgctgtt agacatttac agttttgtca
tttctcatta ttgtaaacag caatgcatgg 19620tacatttttg ttcataaatc
tttttacttg attattttct aagtagcttt caaactcttt 19680aatcagtaga
accccccccc tttttttttt tttttggaga cggagtctct ctctttcccc
19740caggctggag tgcagtggcc cgatctcggt cactgcaagc tctgcctccc
gggttcactc 19800cattttcctg cctcagcttc ccgagtagct gggtctacag
gcgcccgcca ccaagcctgg 19860ctaatttttt gtatttttgg tagaggcagg
gtttcaccgc gttagccagg atggtctcga 19920tctccatctc gtgatctgcc
cgtctcggcc tcccaaagtg ctgggattac aggcgtgagc 19980caccgtgccc
ggcctcagta gaaccctttt aactgcaatg ttaagaaact cattattcat
20040tcaacacaat agttcttaac cctggccaca cctttagaaa aaaaatgata
ttcaggcttc 20100atctaagagt tcagttcagt gtgttggaat ggagattata
cgtaagtatt taattaaaaa 20160ccaaaagccc ccaagtgatt ttaaacagcc
gcagttgaga accaccgatt aaccagtgtg 20220tcaagggatg gcactgtgat
atgctgagca taaaaatatt gcacaggatg aaaccctgtc 20280tctactaaaa
atgcaaaaat tagtccggcg tggtggtgcg cgcctgtagt cctagctact
20340cgggaggctg agacaaggga atcgcttgaa ctgggaggca gaggttgccg
tgagccgaga 20400ttgagccact gcactccagc atgggtgaca gagtgagact
ccatctcaaa aacatgtata 20460tatatatata cacacacaca cacattgcac
aagaacagcc acaacatctg tgctcacaga 20520acatcagcat gtggtctaac
ttcaaagtgt tgtaataatg cggtttgaga ctaggttatg 20580tttgctgtga
tcactaagtt aagcattagt gagcaaggag attgagaaaa tccttaatat
20640aaataatatt tcttaatata actataattc ctaatataac taaggtctta
atttatatgt 20700catctgttta gtaaaggttg gttttggcat gattaagtct
tgcttgctta atagatgttg 20760gaaggataat ttcatgctta tcttctttgg
acagctgaat caggattaat acccagatag 20820ccttgaacat aagtgcttgc
aaagcacctg aaagaaaata agcatcttaa gcccaataca 20880acacaatgat
gctagtctag atcttggatt aagtgtttta atacttttac tctaattgcc
20940aagttatctt cttcctaaat cttcatgaga aaacccacta aaagaatgct
ttttcctggt 21000agccttccat tgtgatcata aagtttggaa gtaaagttga
aaataaacat gtgggccagg 21060cacggtggct caggcctgta atctcagcac
tttgggaggc cgaggcaggc ggatcacaag 21120gtcaggagat caagaccatc
ctggctaaca cggtgaaacc atgtttctac taaaaataca 21180aaaaaaaaaa
attagccggg tgtggtggtg ggcgcctgta gtcctagcta ctcgagaggc
21240tgaggcagga gaatggcatg aacccgggag atggagcttg cagtgagccg
agattgcgcc 21300actgcactcc agcctggccg gcagagcgag actctgtgtc
aataaaaaaa aaaaaaaaac 21360gaaaataaac atatgaataa aagttaaaaa
tagaaaaaaa acaagaaaat aaacatatat 21420ttctgacctt attgattctt
gatattttat ctgcatggaa agctattttt tggcagttat 21480tattgttctt
attttagaga cgaggctgag caggaagggt cctttgaaaa agaaaagatt
21540gcccttgaac ccctctggca agtgggatga agtctgcttc ccagcctcta
acggccttct 21600tttcattttc ccttgcagtt cagctctgga ctgttggaaa
ctatcactgg tatctcaagc 21660aaagtttatc cttcagcacc tgtgggaaga
gcaagattgt gtctctgatg tgggaccctg 21720tgaccccata ccggctgcat
gttctctgtc agggctggca ttacctcgcc tatgattggc 21780actggacgac
tgaccggagc gtgggagata attcaagtga cttgtccaat gtggctgtca
21840ttgatggaag taagctcctg ggaagtgtgt ccatgagcct gcaaggggtc
ctgagcctag 21900ggcctgcaga tgtggtggtt tgactggaac agtggggaat
ctttatttgt tttggctgtt 21960tgggttactt gtttttttat tgaatgggat
ataaggtggg gtatgttctc tcctgagaac 22020cattgtcccc cctcccccac
cagtttcctg ttatactgca tctgtggcct tcacacgttt 22080acttgcctgg
cctttgaaga cactgaaaac tttgactcta ggtagagagg atgacaacag
22140tacagtcttg tgggattggg tgtgttagct ttatctgttt gccctgacac
agatttataa 22200ttgaccctta taccacccca cttgtgttgc tttgtttcct
gatacaaatg cttgctgata 22260tatacctctc cagtatgttc agttcatgca
taaacgtttg cctaatatga agattaggtt 22320tatattttat aatgaggtag
aaggtttttt tagggggtgg ggtgggaagg gcaagactga 22380agagtgaagt
agtcacctta atgaatagtt tcattgctga tatgaaaggg agcactggct
22440tctaagattg taatgtgagg tggatattaa ttcatattct gtgtaatatt
ctacataata 22500ctgattttat agtcatgtat tctatataga gaacttaatc
agatctgcgt tattaccaaa 22560tccacacata ggaaagtgct ttaaggattt
tgaaagtatt aattcccttg gtttagtgtg 22620gcttggttgc aggcccaggt
ttaaagctag aggtctgacc tcttggcctt tttgccttag 22680tccctggcac
ctgaaactcc aggtactgag atggactccc ctaggcctag aggtgacaat
22740agccaattat ggacagaacc catgacattt ccccatccca cactgttttt
agacttgttc 22800ctgagaaaaa cattgaaagt tatttttttg tgaattgcca
ttattgttta gatatactgt 22860gatgttcaga tggcttatct tacaaattga
atatccctag gtctaatcct cttctttctt 22920tttcactgca gacagggtgt
tggtgacagt cttccggcag actgtggttc cgcctcccat 22980gtgcacctac
caactgctgt tcccacaccc tgtgaatcaa gtcacattct tagcacaccc
23040tcaaaagagt aatgaccttg ctgttctaga tgccagtaac cagatttctg
tttataaatg 23100tggtatgtta taaaactttt gccaagatgt tctgaatcaa
gtcccttcta ctcctacata 23160aaagcaaatt atagtttggt gttgccatag
gtctagtgtt tctcaaaatt tttaagtctg 23220cagttgatat cattatcatt
atgatattta attgccttgg gtttttgttt tttttttttt 23280taatcctata
ctggtttgta cgagccattc cttttccctt actgacttga agagtcagtt
23340atttaagaat aacattggac tctggaaata acatagtatg ttatacattg
ttaacatgtt 23400ttactctttt catagccttt acacatattt tcagttgatc
tcatccctcc taggagctgt 23460gtcagagatg gggttttcct cttttgtaga
tgagggaaca cagtgtcaga ggttttgtaa 23520tttgtttgaa caagaatgga
caaggacctc aacacaggtg ttctagctcc taatccactt 23580gtcctgccac
agccccattg ctgtcagttc ttcattactt tcctgatgtg ctggagaatc
23640tgaaatttgt ttttacttgt gagttctgtg gttatgtcat aaattctgct
ggcatatggc 23700agtgttagcc ttgttttcaa atatcttttg aattctcaga
aaaagcctag atagttgcca 23760agagagaata atcaaaatta attaatttaa
atgggaagtc cttactttca tatcagcttt 23820tctgttaagt cagcagccca
ctgtgtacat ggatcctatc tggatgtatc accagtttct 23880ctgattatag
tttcagtgtg taaaatgctg ttacagtcct ccttaaactt ttcaaaatag
23940ctttaaaaaa aagtgcaaat atgttcattg tcaaggcaaa aagaatcaga
tgtaagcttt 24000tgtgggactt aactgtatga tgctaatgag tttatatgtc
actttatgat gtatggtatg 24060ttttgttctg cattcactta aaaaatagct
ttatatcatt catctattta aagtgtacaa 24120ttcaatggtt tatatgtgtg
tgtatgaata tatatacata tgtatatgta tatatatgta 24180tattcacaga
gttgtacagc catcaccacg atcaatttta ggacgttttt atctcctcag
24240aatgaaaccc tgtaccaccc tgcattcatt ttacttgaga gaaaactccc
tgtgatgaga 24300taggacaggt tgagagctcc acttttgaaa gattgttcgg
catcaatatg tggggttggc 24360cataggtcag gggcacctgg aggcagagat
tctagttagg agaagctgtt gtcaagtgtc 24420caggcaggag ctagcaagag
cttgagccag agcagtgttc atagaaatgg aaagaagaga 24480aagatcataa
caaatccatg aagtaaaaac cctgagaagt taaagaaccc actggggaga
24540gtttggatat aagagaatct ggaaaaagag atcttggact ggaacaggtc
agggctccgt 24600gcccaagtgg aagggaaatt aagaacttgg agtcaagtgg
tagacatttg agtggtgtgg 24660agacaagttc gttgccaaag ttttcaaaga
tggtgtttga tgcatcctga gtatcactcc 24720tttttccccc tcattgcttc
ttgattgttt attatatgcc aggctttttt ctagtacttg 24780gcttgttgta
ctagaaaact agttgtactt tgtctacaac ttgttgttct aggtgtagac
24840aaaagatatc aattaaatat gatctatcag atggcaagtg ctgtggagaa
aaattaagca 24900aaataagggg tagggagagc ttaaggataa gggtttacag
ggggaaggtg tctttcctat 24960ttagtgtgat cccaaaggcc tctctgtgaa
ggtgacattg aagcagagac ctggtgagaa 25020tcacagtggg agccacgcag
acatctgggg taagagcgtc ccaagcattc tatgcttgaa 25080ggcaaagaag
aaaaaagaaa gagcgttcca agcagagtaa aaagcaacca ccgaagtgcc
25140tgttgtgttt aggaaatagc caggaggcca gggtggctgc agcagagcaa
aggaggggaa 25200ggtggtgggt gagttcagag tggtgatggg aatctgctct
tgtagggcct tgcggctttt 25260actccgagtg agataggagc caccagaggg
cttagaacag aggagtgcag tgttctggct 25320gaatttttta aaggcttgca
ttggctgctg tgcagtgaat aaactggatg aagaatagaa 25380agaaaatgtc
ttttaagcag gtgcttagga ctttggagaa tttgaggata ttgagaggtg
25440gttgaagaca gtggaggaaa ttgtccacag cactgggctg agagggtagc
cccttcacct 25500ggtcttgctg agatgtggcc tttgtcaggg aagattatga
ctgatgtgtt cttaagagga 25560aagcagagat tttaaggagg ttgagatgtg
attattttct agattgctgt ttgccttcta 25620gaactcatta attgcagaca
ccatcccctt agtattaggt gaaatcttat aatttacgat 25680gataatattt
gcatttttgt tttccaggtg attgtccaag tgctgaccct acagtgaaac
25740tgggagctgt gggtggaagt ggatttaaag tttgccttag aactcctcat
ttggaaaaga 25800gatacaagta ggttcttaat tatcttgggc ttctgggaac
agaatcagcc agcatgcagt 25860cctaaattca gccatctgat aacagttcta
tgcctgttgc tgagtggaac aagaaataaa 25920gacaacaccc aggccctgac
tttcggatct gattggagaa gccagtcatg tagtttgtct 25980gaatgccata
taatttgata ggtagcagga gagcatgagt tgtaagccag cctaggacct
26040actcccaata gcgcttggtt ctccaggaaa aatcatgtgg gaaagatgga
gatgacaatg 26100ataaggcgga gctgcattct cttacataaa tggggatgta
tgggttgtta acatggatga 26160cctaatgcag cctctgtctt tgctccatcc
cagaatctag aacttctggg tgctgtgctt 26220tgaggctcct gggatggaaa
tcagaatgca ttcttccatt gaaacagtat tgtaaacaat 26280tggatgttat
tgaatacctc aggtacacta taggcatttg caaaatgacc tagaaaccaa
26340attataatgc cacatctgtg agagaacttt tttaaaaagt accacttatt
gagtacttac 26400agattaaaaa aacaaagtgt agaggttagg taacttaccc
aaggtcatgg acctggtaac 26460tagagaattt agggtttgat tctattctgt
ttgataagtc catgttcttc attactaaac 26520tactctgcct ccagggaaca
tttattgtta gattaataga aataattaac tgagtacaac 26580aaatagcaga
atttaataaa taatgtttct taaatatatg tgatatattt aataaataca
26640gcagaagtgt tcaacctctg tatgattttg aggctgcctg tataatgctt
agtagttttt 26700aaagagcatt tacatgcatt atttcacttc atagacttga
aaccactaga gtagagatag 26760aggacaaatt agaaagtatg aggcagttta
gaatatagtt tcatttaaaa aaaattgatg 26820gggataatgc caattcgtct
gagatttcac agaagacatg agtactcatc gtgatcttgg 26880ggaagggata
ggtttggggt tggcaaagaa ttgggaacat tgggtctggt ggggaagaaa
26940gtgtcagtga aaaccagagg tgggactgat cctccatggg atactctatg
tgaatgcaat 27000ggagagcctg agtccgggga gagatgtttg aggaggaaga
tcaggctagt gaccaacttc 27060ttcagtggga gctgcggatt tgccacctga
tctaaaaggc aggaagtagc cattgtcggt 27120tcctacgtga ggtgacaaga
acagtgcgct ggtcaggtgt ataaatgcta ccaaagaatg 27180cattagagac
atggagacca tctctcaagc tagtcagtca gtttaatgtg aggtgcttag
27240gaaaggaccc attctactgc aagtgacata cctgccagag cctggtttga
atgctggtaa 27300gtcatggcag tggaaaagct ctggggttca ttagtgtagg
gactagggct ggtaattttc 27360ttgtgtagtc agtttcctca agtgttctct
tcaaatttaa agatttcagg gtatgagaaa 27420tttagggaaa atataaaaac
gtattcttaa gccagacaaa gattaatttt agattttgta 27480gtatttggta
gtatctcagg ttttgtccct ccaaataatt aggagtggac tgtatacaag
27540atgcttcagt cttccttcat ccaggaacgt ctcagtggtt tttaagtttt
attcatgtct 27600tggatattct tcaatattta caatagaatc cagtttgaga
ataatgaaga tcaagatgta 27660aacccgctga aactaggcct tctcacttgg
attgaagaag acgtcttcct ggctgtaagc 27720cacagtgagt tcagcccccg
gtctgtcatt caccatttga ctgcagcttc ttctgagatg 27780gatgaagagc
atggacagct caatgtcagg tattgcagtt tttccctgta ctccacatgt
27840taagcaaatg gagttaggtt tttgtctttt atgagcatac aacttttgac
ttctattgat 27900caaggttgag gagcagtagc tttcttgtta gacacactta
acaagaaggt taagtctagt 27960tatgagccat gtcaaaataa cagaccaaaa
atatatcaaa aagtggtgaa aaataggata 28020aatattagta gatgaagcaa
ctttttaaag atatgttaaa tattttaatt tagcatctac 28080ccacattttt
ccagcgtgat tgttatatgt tataattgat tttaataact gtcaagcata
28140attagagtgg ctaattctca tgggctaatg tgatgggaag aaattttgta
taaatgcagt 28200catgcgcata tatgtgtgtg tgtgtgtgtg tgtgtgtgtg
tatacatacc ttttctatgt 28260ttagatacac aaatacttga catggtatta
caattgcctg tagtattctg taaagtaaca 28320tgctgtccag gtttgtagcc
tggtagcaat aggccatacc ccataggcta ggggtgtagt 28380aggctacacc
acctaggttt gtgtaagtac tctatgatgt ttgcacaatg atgaaatcac
28440ctaacaacac atttctcaga cgtatcccca tcgttaaatg atgcataatt
gcacatatat 28500gctttgtttt gatgtggtga cttcaaaatg cttcttccag
cctcctcttc tatatatcct 28560attttgtacc tgactacatt taccattaga
aagtctctat tcttctttgc tgaaatttca 28620ctgttctctg ggcctgagtt
ttgttttgat tcctgactat atcttcatta tgtaacaggt 28680ttcagttaat
gaatgctctt ctgtgtaatg taagccctgt tgtatagttg atagcatttt
28740ctagccagtt cccagaactc cttgtttcca gtgtcaatac ttggcacctt
tgtccactga 28800cactaatccc cagattaatt tgtaattaaa gccctactgg
tgagatttct gagaaacgtt 28860gttgcaaaat taggaacctt tcctttatat
atatacatta cataaattta tagacataaa 28920acattttaat gcagtcattt
gctgctactc tttgactcat agtctttcgt gatattttga 28980aaaagccttt
tgttaacatg tctaaatgca gaatatgttc tagaaatatg tagcacttaa
29040agtaagccat tagattacct tttgaaaagc ggagcaattt actaagtttc
tacttcttca 29100gatttgaaat tcttcatcat tagcttgtag aggcaaaagc
ttgatgcagt catctcattt 29160gctgtaaagg aaatgagaag tcatttacag
tatatttcta ctgctttgac ttttatttct 29220caaaaagact gttttgttca
tataaaatat taatgctttt gaggactaca aagtccctcg 29280atttagttta
catttacttt agcttatact ttgtaaaaaa tactcttcta aatgctttgt
29340ctgttttagc ttacttattt ctcataatac ctctgtaaag tatatgccat
ttgcaccatc 29400attttacaga tgagacaact aagacatgga gcagttaggt
aacttgcctg agatcatgca 29460ggtggagcca ggatcaaatc ccagcgagtc
tagctccaga gtttgttctc ttcttgacag 29520ataatttatc ctcacaaaat
ttgaagcatt tgtagaggaa ttccctattg ttataatgtt 29580tagttttttt
gtagattggt taaaaacttt gaattaaatg ttagcattaa catcatttgc
29640ttttatcact acttctttgt ctcttttttc tttttttaat cactacctct
tcctcctctt 29700ttgagaaatt ctgcttccgt ggctatggtc caagctactt
gagaaggtga ggtgggagga 29760tcacttgagc ctaggaggtt gagattgcgg
tgagctgtga ttgtgtcaac tgcatttcaa 29820cctgggcaac agagcaagac
actgtccaaa aaaaaaaaaa aaaatagtga aattttactt 29880cgctccattg
actcagggaa aaaatgtaat ggtgataaca aattcccttc atctcattag
29940tgaaaatcca caattttcca tcaatcgata tgatagtgat agagatattg
agtgtgctca 30000ttttcctaca gaccagctgc tttaactatt ttaagcagac
agaaatgata ttggtaccat 30060ccatgtctaa tgaaggcaat actttgtaat
aagttgcagt
aagttgtggc cagaagagga 30120atgatgactt cacagtgtaa acaactacct
tattgggttt gtggaaaatg gtgtcatgta 30180gcagatgtgg ctttatctgg
gctttggttt ggagtagttt tatctattca tctaaccgtc 30240tgtctctaag
tgtataagtg tgtgtgtgtg tgtgtgtata gtattgggtg tgtatatatg
30300tattttgtct acattgtatt gaagtaggta gtgcagcatc aaaaggaaat
tgttgatttt 30360caaaatcagt gaaatgtcac tatttttgag aaaaatggtc
tgtttacact cccttctcct 30420tttttttgtc agttcatctg cagcggtgga
tggggtcata atcagtctat gttgcaattc 30480caagaccaag tcagtagtat
tacagctggc tgatggccag atatttaagt acctttgggg 30540tgagtatcaa
ggtgttagga aagcatgtta tgacttacat agatgcttag ttcttaagaa
30600catgtacttg tatcttgtca gttcaatatt gattgtcagg tcttttaact
accctggaaa 30660accctaagct ttagagtgga attggcaagt gtattctact
cctgtttcct cttttaatga 30720actaacgtac tcttaaaaaa gtgattgatg
actatcgcag ggacaaaaaa cgaaacaccg 30780catgttctca ctcataggtg
ggaactgaac agtgagaaca cttggacaca ggaaggagaa 30840catcacacac
ttgggcctgt cgtggggtgg gggagggtgg agggatagca ttaggagata
30900tacctaatgt aaatgacaag ttaatgggtg cagcacacca acatggcaca
tgtatacata 30960tgtaacaaac ctgcacattg tgcacatgta ccctagaact
taaagtataa taaaaatata 31020tatataaata aataatgcca gcattagaga
aaaaaagtga ttgaaattgc atgttaagtg 31080ttttagcaaa tgttgatgtt
gatggttttt tgcaaagagc gcatcagcta tttgtgaact 31140agatctgtga
atcttgcaga gtcaccttct ctggctatta aaccatggaa gaactctggt
31200ggatttcctg ttcggtttcc ttatccatgc acccagaccg aattggccat
gattggagaa 31260gaggtaggtg aacacggagc aggaaattta cttaaagtag
ttacccaggg actgatggca 31320ttaagtagaa agagcgtggg ctttggaggt
ggacttgggt ctccactaaa tgcctagaca 31380atagtgggaa atgatctcac
tttcataagc cacaccttat tcatctataa aatgggaaaa 31440tcagtatctg
tctatcaggg ttcagaagac taaatgagat aatatatgtg attagcaacc
31500ttttatccct agttgtacaa atcattcaaa gttaatttta tttagtaggg
gaaacagaaa 31560tgtgatcttg agaatagttt tagtagattt ttattcaaca
catactagaa tgcctataat 31620tgtggtggat ggtagaatgc agtggctgga
aaacaaaacc gcttgactaa ttcctgctct 31680tctggaactt gtgatctatt
aatttcaatg taatgattcc ctttgttggg agtgtgatgg 31740aaatggacag
agtatactgg tagagaatac tgagatgttt gaggggtaat ttgaggatgg
31800tggctatgag aatgggagtc ctgcatctgg tggtccagga aggcctctcg
gaggcagtga 31860tgtgtgtgct gagatgtgaa gaaaaagaag gctctgtctc
caggcagaag gaacaacaaa 31920ctccttgagc ttagcaagag ctcatcttat
tcaagggact ggatggaagt attgtggctg 31980gagctcagtg acagtcatag
gagggaattt gggttcttta attgaacaaa gattagaaac 32040ttcttgtgat
ttttaataac agagtaatgt gttctgcttc atggtttgga cagtgattct
32100ggctgcccag aagagacttg attggagagt gacgagactg gaatatggga
tcaacaccgg 32160ttgagtggag ttagtgaggg gaaaaaggag atgggtttga
gatatgtgta ggagatggag 32220atgtcagggc tcactgatgg attggatggc
ttcacattcc gttttgcact ggaccagcca 32280cgtcttaggt atctatcttt
agtcctgatt acaggaactt aggtgtgaaa tcatagggtg 32340gtagaactat
gtgatagaaa aggtaggttt aactgatttg agatagaatt gcttgtgatt
32400tcagttttat ttctttgcag gaatgtgtcc ttggtctgac tgacaggtgt
cgctttttca 32460tcaatgacat tgaggtatca aggcttggtt tggtgttgga
tccttttcac agtgttagct 32520ccgagtaatc tagctagctt tcacccatgc
ctctctggcc ttctcttgca ggttgcgtca 32580aatatcacgt catttgcagt
atatgatgag tttttattgt tgacaaccca ttcccatacc 32640tgccagtgtt
tttgcctgag ggatgcttca tttaaaagta agttttcaat gtataaaaca
32700gaaatggtcc cttctccaat gtcttttgga gtcttgatga ctttttgaat
tcttcattta 32760ttttggcttt ttatcaagga gtcctaggct ggagaaaatc
tttagagtta ttttacttag 32820accctaatct caacataata tctcagttaa
atcattctgc actttagtaa agacatccaa 32880ggaagggagt tccttcctta
agcagcacat tctaaagtta aaaacttttc aggaaatttt 32940attatgtaac
tgatctaata ttttatttgg aattactatg tagatcccca atgttttacc
33000ttctgtgtag tcttttccca ctgtgcccac cctccactgt acatctgcgc
tccatctagt 33060ggtttgtagg atattggctg cattttgtct tctgttccat
gccctatcta tctctgtgtg 33120tgtggcgtgt atgtgtgtgt ggcgtgtatg
tgtgtgtggc gtgtatgtgt gtgtggcgtg 33180tatgtgtgtg tggcgtgtat
gtgtgtgtgg cgtgtatgtg tgtgtggcgt gtatgtgtgt 33240gtggcgtgta
tgtgtgtgtg tgttccttat tctaaaaagc caacttattt tctttgcttc
33300caacttggaa atagggaatc tttctttcat tgatatgatt atagtacact
gataatgcta 33360agaaatagag aagttgcccc aattcttaac tgtgtttctc
cacatcattt gagaagctgt 33420gtatgtgaat gtgcatgagg gctctgtaag
agagagggca agttccaggg atgagcgtgt 33480tcatcagcag ggctgatagt
cttgaggttc agtgggagag ctaaggcaca tggttgttat 33540ttgttctctt
ctatttcaca taatgtgtgc ggtttcaatt gcagttaatg gagagtggct
33600tgttgtgata attaaggctt attagttaat ggtgtgttta gcattacagg
ccggcctgag 33660cagcaatcat gtgtcccatg gggaagttct gcggaaagtg
gagaggggtt cacggattgt 33720cactgttgtg ccccaggaca caaagcttgt
attacaggta agctggtttt tcagacaaga 33780tagatagtct gattgtcatt
cagccaagta ccaagcataa ttcttgcagg ttgtatttta 33840ggctttctta
ttctttgtat cgtttattgt aaacctttcc ttgatagttt tctgttagct
33900ttattcaaag gagtgttgat acaggctgtg accataaggc tcaaagcgaa
acttttcttg 33960aaagtcaaga taaatataga gaacaacaag attctgctaa
aagtgtgctg attttagaga 34020gttgtggtaa ttctctgtga agagttaggt
aaaatggtgt atcctggcta tttaaatgtt 34080ttctacttaa ttaaaaatgt
tactgcttta atttatttaa gatgccaagg ggaaacttag 34140aagttgttca
tcatcgagcc ctggttttag ctcagattcg gaagtggttg gacaagtaag
34200tgccattgta ctgtttgcga ctagttagct tgtgatttat gtgtgaagac
aataagtatt 34260ttattacaat ttcgagaact taaaattatg aaaagccctc
attacctata tcatcaatca 34320gattcttaga ggctcttttt ttttttttta
acttttttac tttaatgcag tattttgtag 34380tggagattcc tagcagaaag
aatcgtgaca ctcatcatat aaaggagggc ttctcttaac 34440ctgagggaac
acatgtgggt tttaggtggc ctgtgaaccc agggagattg tacacaccaa
34500accttgtctt tgtgtattta ttcaagtaga aagcccacag ctttcaatag
atttacagcg 34560gggcctatga cccagaaaag cctgagctac tcttgtgaag
gaaatgactg attttctgaa 34620cctatttgga ggaaactttg tattggaaag
atctatacta atgttttgtt taaaaagtag 34680acctgaattc catgatgatt
ttctttgttt tttttttgag acagagtctt gctctgtcac 34740ccaggctgga
gtacagtggc gcaatctcgg cttactgcaa cctctgcctt ctgggttcaa
34800gcaatcctcc cacttcagcc tcccgcatag ctaggattac aggtgtgcac
cacgcctggc 34860taattttttt ttttgtattt tcagtagaga cagggtttca
ccatgttggc caggctggtc 34920tcaaactcct gacctcaagt gttctgccca
cctcggcctc ccaaagtgct aggattacag 34980gtgtgaacca ccgtgcccgg
gcttctgtaa tgattttctg ttgtatgtat gtgaagatgt 35040agttctcaga
cagtcatgat gactaaatta caccttttaa gaaggtaaat gaatgtggta
35100cctgattttt ttattctgta atttcagagt agaaatccag tgatagtagc
ttggcattgg 35160ggctgtaatc tgattataac tggtttgtat cataatgaaa
atatgctggg cccatggagc 35220tcagtttttg tgaatatctt ttctattctt
tctctgtctt ctcacagact tatgtttaaa 35280gaggcatttg aatgcatgag
aaagctgaga atcaatctca atctgattta tgatcataac 35340cctaaggtaa
ctttctaagc tgtcatttac tctagcttac tttgtactta aactaatatg
35400atctgaacga agatgttttg tccttttttt ggtaggtgtt tcttggaaat
gtggaaacct 35460tcattaaaca gatagattct gtgaatcata ttaacttgtt
ttttacagaa ttgaagtaag 35520tattttgaat aattcatgtg tatcttttcc
atagttttct ctcttcttgt taaggaaatc 35580aagcataaat agctagagaa
gaaaaattcc ttactgttca tttttaaaaa ttgctataac 35640tcttagatgc
cagttggttt tttgctcttt tccgttcttt ttaaaacagc ctgtttaaaa
35700ctatgtcctt aaaacatgtc attcagaatt attatttcac ttgattttta
ggtatacata 35760taaaactact tgtttttcct aggagactga aatcaaatgg
catctttctc tctgatgatc 35820tttcccctca actttttaat gaaacacttt
caaaatagag aaaagttgag agaattgtcc 35880agtaagcaac ctatatatac
cccacctgga ttcgccagtt tatatttttc tgtatacaca 35940ttctcattct
ctataatctg tccatccatc attcatcttg tttgtagaca aattgctaag
36000tgagttgtag acatcagtcc actctaccac ctgtacttct ccttgtatat
cattaactag 36060agggcattct ttgtgtatgg gttggttttg ttgtgttttt
tcaggtcata tttatctaca 36120gtgaaatgtc caaatcttaa gtgtgccact
tagtgagttt tggcaaatgt acacttcatg 36180taacctgaac ctctgtcaag
ttagagggca tttactcctt ttcagaaagc tgcttcagat 36240tcctttcaat
cagtccctgt cccattcccc aggcaactac tcttctgaat tttttaccat
36300aaatcagttt tgcctgttca agaacttcac ctaaatggaa gcatacagta
ttactcttct 36360gcataaagct gttttcattc agcatattgt cttgagattc
atctgtgttt ttatatgtat 36420cactagttca ttcttttttt attggtcagt
agtatgccgt tgtgtaaata caccactatt 36480tgcttattca ttcccctgtt
gctggacatg tggattgtac taccctgttt ggggctaatg 36540tgactaaaac
atctacaaac atttgtataa gtcttttgtg gacatgtttt atttctcaat
36600atttttataa ttcaactctt ttccaaaagt catttttatt tatcatcatc
agcatgccag 36660gtgtatgtta gtaatttgat cgctgggcta catgttctgt
tgatgaccat tccatacaca 36720cctgttctta gagaagaaga tgtcacgaag
accatgtacc ctgcaccagt taccagcagt 36780gtctacctgt ccagggatcc
tgacgggaat aaaatagacc ttgtctgcga tgctatgaga 36840gcagtcatgg
agagcataaa tcctcataag tatgtatgct gtcaccaggt ggcatccttt
36900gaaaaaccga agtgtgtagt tgtccttgtc cagcctactt acctttctca
ttctggtgtt 36960cttcacttat tacctcagat actgcctatc catacttaca
tctcatgtaa agaagacaac 37020cccagaactg gaaattgtac tgcaaaaagt
acacgagctt caaggtagag atccgctcac 37080agagaaagtg cttaaggtgg
ccgtgactgc tactagtctt ctgcaggtga caatcaccat 37140gtcattgcca
caccacagat ttaacatgtg actttttagt tgccatttta agacccttgt
37200cagttttttt cagtgctgcc ctctaaagca tatataaaag tatcagaagt
atatattctt 37260ctgatgtcca gttctattga gaaaaattta ttgtcttttt
ggttatgttg ttaggtctgt 37320ggattttttc cccaaatgat tgtgttctgt
tttgttttct aaacactgtt aggaaatgct 37380ccctctgatc ctgatgctgt
gagtgctgaa gaggccttga aatatttgct gcatctggta 37440gatgttaatg
aattatatga tcattctctt ggcacctatg actttgattt ggtcctcatg
37500gtagctgaga agtcacagaa ggtatgtgga gttcttactt ttatgccatt
tggttcttgt 37560ttatataatg atagtgtgaa accctgcttc tggtagtgca
gtagcttttc tgctatcact 37620ctgtgagtgc agggctggag acagatctgt
gagtttctag ggcccacatt cctaagcccc 37680tgtgcttatg aaagtgtttt
gattgtgagg ttgaagaagt gaagtaaaat tgcatggctt 37740ttttttgttt
cttttttttt gagacggagt ctcactcagt cgcccaggct ggagtgcagt
37800ggtgcgatct cggcttactg caagttccac ctcccgtgtt cacgccattc
tcctgcctca 37860gcctctctag tagctgggac tacaggtgcc catcaccacg
cccggctaat tttttgtatt 37920tttagtagag acagggtttc actgtgttag
ccaggatggt ctccatctcc tgacctcgtg 37980atccgcctac ctcagtctcc
caaagtgctg gaattacagg tgtgggccac catgtgcggc 38040ctaaaattac
atggttattt ttaagatgat gggcatatgt gtgagctaat ttcttctctt
38100ataaaggaaa tgtaacaagt ggttcatgtt ccactccggt tctttctcac
atggctcttt 38160tttctagtgg agggtgggca catggagcac agaaggctca
tggcctcctt tcctatgttg 38220gtacatttgc tatgatcaaa aactttgaac
accactggta tgcatatttt ttatttattt 38280ttttgcagcc tcagtctctt
ccccatgacc tctccaaaaa tgaaaatcgg atccttcatc 38340tctctgctta
aaatacttca tgagctccca ttgttccgag gatataattc agaagccata
38400atactgctta aaaacccttc cttgacctgg cctctgtgta tctttccatt
ctcacttctt 38460ggtattgtct ttttttcctc tgcccatgga ggaaagacaa
tgcttttgtc ccccttccct 38520tgcccctcac caccacatgc cttggtgggc
agcattactt ctgccatcca tgggctttga 38580ctgcttccac cctcaccatt
cccctggcta attctcacta atctaggtta aaggatgcca 38640aggtggcctc
ttcccagtaa gccattcatg cttccctcca gggactgggt gaggtgaccc
38700tcctatatgc ttctgttgca cacagtgcct acccctgcag actacagtgt
gtctttatct 38760agagtgcggt atttatttat ttatttttga gacaaggtcg
ggctctatca cccgggctgg 38820agtgcagtgg caccatcttg gctcactgca
acctacgcct cctaggctca agcaatctca 38880cctcagctta caggcgtgca
ccaccatgcc tggctaagtt ttgaattttt tttgttgaga 38940cggggtttcg
ccatgttgcc caggctggtc tcaaacttgt gagctgaagc aatccatctg
39000cctcggcctc ccagagtgct gggaatgagc acttaattat ttgttgtctt
gggttttctt 39060cctatgttgt tcttacatgt atttatcctg tcagcccagg
gaaattgcat taaaaacagg 39120aaacacctct ccattaggaa gaaaaacaat
ttgcttacag ggcatggcat agagctggag 39180atgatagtgc caataaatac
taggttggca gggtctcaga gttttgtgtc caactcagta 39240taattttatg
tttgttttaa tgtgatcatt tcaggagagc atggaatgtc atgaaaacag
39300caccaagagc aatgtcttag acttttagga gaaacttaga tgcatttgtt
gaatatcttc 39360tagactgaaa ccttatttcc cttattagcc tatgaaataa
atgatactgt gagacttagt 39420taaggaagtt actattattc caagtgtaac
ttattaatat ccgtatgtga aagcattttt 39480gccaaagctt gtttgatgtt
cagctgaccc ttgcacaacg tgagtttcaa ctgtgcgagt 39540ttgaactgtg
tgggtttatc taaatgtgga tctctctcaa acacagttgg ccctttgtgt
39600ccacggcttc tgcatccaca atcagtgtgg atcaaaagta caatatttgc
aggatttgaa 39660acttgcagat acagagggcc aacattttgt gtatccaggc
tccatggggt caaatgtagg 39720actggggtat gcttggattt tggtatcctt
ggggtgtcct ggaaccaatt ccccatagat 39780actgggggac aactgtagtt
tgattttata tattatataa tatgcagtta atatataata 39840cacatttaaa
aattatgtag ctttgggttt attgctatat gtaaatgcta gtttctattc
39900ctatatatga atatcacaag taataaagtt ctcattaatc atttttttag
gatcccaaag 39960aatatcttcc atttcttaat acacttaaga aaatggaaac
taattatcag cggtttacta 40020tagacaaata cttgaaacga tatgaaaaag
ccattggcca cctcagcaaa tgtggtaagt 40080gtggggatta gtatgtttat
ctctacttca gatcttcttt ggaactaggc aaggtataaa 40140ttaaactgtt
agtttagaca gtgactgatt tcacttccca ctcctgaaaa ctctaacaat
40200tatgtatgct cacgttattt tgtcctgtgt tctgaaaagc tgaaggtaat
cacttttaat 40260gaactggagg agctccctag gtaagaacgt caagtagatc
cttttttggt taagaatgag 40320cacctgtgaa gttaacttca gtgtctcaga
atcaaaattg gttgacagtt cttccttctc 40380atgctgtttg cagacatgtc
agggaaactc tgcttgtctg gagagagtga tgaggccacc 40440tccccgtgcc
ctgcaagacg cagttttaat tgacagtgat ggggtgccag ttgttcttcc
40500catgctggaa cagttgtgat tctttactga ggactgatgg gggaaaggaa
gaatcacctg 40560gggtgcatgt taagccttca gctgctggca tccttggaga
atctgattca ggtggtctgg 40620gataggactg aggcgtgcat gtgtctaata
agcttcccag gtgatgtctt ttcaaggagg 40680ctgagaaaac actgggctgg
aaagctggga ctcttaagta ggatgctgat cccaatcagt 40740gctgctcttg
cctcagaatc tgcagtggtg ctcattaaaa attcaaattc caggatccca
40800ttcttcagat tctctgatta tttaggtctt aaaaagttcc tcatttattt
tgtttggtga 40860ccattggtat aaatgaagtc cattatgctt cccatgtctt
aagcctgtct ttgtgtgaat 40920ctttttcctg caggacctga gtacttccca
gaatgcttaa acttgataaa agataaaaac 40980ttgtataacg aagctctgaa
gttatattca ccaagctcac aacagtacca ggtatgtggt 41040atgtgaaaat
gaggctctcc tggttttgct ttttgcttta gtaggaaagg agtgaggatc
41100ctaagttcat aacaccatcc ttggcttcaa aatttatctt aaaactaatt
agcctcaatt 41160tgaacttctt atctgggaga atggtcctga cctgttctct
gattcctcat ctggaatacc 41220acagcacctt cctcgtgggg ttccctgctt
ctttcccacc cctcctctag cccaacctta 41280ctgctgtaag tctgattatc
ctaacaagta cagatctttc ccatatattt cagcataaag 41340ggaaattttt
gtttgcttga aaaagcatcc ctttagcttt ttttatatac cacacacttt
41400gcttctaagt taaatgtgtt atatgatcct cttaacagcc tcatagggtg
ctgtacacaa 41460tttgtagatg aggaagcaac ttgcctgagg atccagagct
acaaagtgct ggacctggga 41520tacagagccc aggctgcctg accaccctgc
ccatgccatt aaccaccact ctaccatgcc 41580accagcatca ccattttcag
tttgtcctca gacaatatac acatctttct ttgatcaagc 41640ccctgccagc
ttctttagca ccagcttctg ccactgtcca cattcccagt tacttgtagg
41700tagttctaca gatgtcacat cgtgtgattc ctctgtcatt tctctaccca
ccagccttcc 41760tttagcccca tttgtccatc agaacccttg ggttactcct
gaatgccatt cctggaccag 41820gcgccaaaca ctgagccccc agagcagcct
gccctcgcct tggtgattgc atttgtcaaa 41880ctgctgatta gctggtttgt
cacctccacc aggctgtggg ctccttaagg gcagggactc 41940catgttgtat
tcctctctga atctctggct aacatccagc ctggagaatc gaggatttgg
42000ccagtggata cctctttgcc cttgttttct gttctcttcc acactctctc
tgctctagtc 42060acactggccg tcctgttact cctcagacct gctatacaca
ttcctgctgc atggccatgg 42120tgccttctgt gccctctgcc tggtgccccc
tatctcatca cgtggtttat tctcctgaca 42180gccattagag ctcacactcc
ctgagagctg caaggagact gtcctctgtc cctttactca 42240cgtttgccat
tatgctatag actatatttt gtccctaagt ccatcctctg ttactataag
42300agcagcaact tggtggtggt tcttatatgg tttttcattt gtttggtttt
attttttgcc 42360ttgctgtagt atccatactg cccagaatgg tgcatatgta
gttaagagta attatttgtt 42420gagtgaataa atggcacatc ctcagtaagg
ttttgaatga aaaaatgact gtactaactg 42480atcaactgta agattttccc
aggtaattct ttcaagggag ttccaagtat aggaactaag 42540gcagctacac
tggagcttta gagaaatgat tgtcatattt cctcctcagt cctaaatctc
42600ctcttgtcac aggatatcag cattgcttat ggggagcacc tgatgcagga
gcacatgtat 42660gagccagcgg ggctcatgtt tgcccgttgc ggtgcccacg
agaaagctct ctcagccttt 42720ctgacatgtg gcaactggaa gcaagccctc
tgtgtggcag cccagcttaa ctttaccaaa 42780gaccagctgg tgggcctcgg
cagaactctg gcaggtaagt acaatcattt atatgtttac 42840atctacaaag
gttttaaaaa atttatttct tttgtttggt aattttgcaa ataaatttag
42900ggcagaatac tctgagacag tcttgttctc actgataaaa attaatttag
aatgctttaa 42960aggataagct actacagcaa gagtcccaga atgcagtggc
ccaatatgga aagaagttta 43020tttctctctc ccatagggat ttataggccc
ttccgttgtg tggctctgca accttttagg 43080cagatggttg tagctgggtt
atctccacag ctgtggggaa ggaaggagag tggggagaag 43140ttagaatcat
ggtaaaacat ttacctttaa gttggaaatg acctggatgg aagttaaact
43200atcaccttct attccatctc ggccacgcca tgtagctgga tgggctgtgc
cctgtaagaa 43260ggtaaagatg aatttttgga tgggtccatt ctgttataga
cagtaggttg ttggaatagc 43320caggaatgag gtggggaaaa taaaaggcca
aatgtcgaag cattctgaaa gcaaaggcag 43380tttagctgcg tcagggacaa
gggttgcccg aaccagaggc gaggctggta ccaggggctc 43440tagtaccaga
gtggaggaaa gggtaaggac acctatgaaa agagatgagc agaagctctg
43500gtcatctcag cagtgcttga agtaaagcaa tgactggtat atttttttcc
ctaacttgta 43560aatattgttg agatctcaaa gaaaaaaata aaaagcagtc
ctaaaaaaat tccaaactct 43620atcctgttaa attttgttaa atttatgtac
cagtccttct ttgtcatttg cagtattctt 43680tttttcttgg gattatacca
gtgtatggga ttatcacttt tctttttctg gttattagcc 43740tttcccaaat
ccctccgttt ccatgctggc ctctttttac aaatgtcgag aattccttat
43800ttcaggcctt ttagttattc gttcggtctc cattgttcct ttctgcttta
gaaatttatg 43860atattggttg tttatacctt ctatctctgt tcttggatct
cttctattct ttacagctct 43920tagcttgcta tttcccatgt cttatgaggg
agtatttcta gtttttctca gatgtttagc 43980aaaagtaggt ggggagggca
gtggtcaaag atgtttgaga aatgttacac actggagtca 44040ctctgtgtgt
acatttaacg taggcagttt acacaagaga gcaaaagaaa ggtaactatt
44100taaatagtgg aggtgatttt acctactttt tttagtgata tatgcactgg
agtgagcatg 44160caatgagaga ccggaatcta ccagctcctt cgaaagcctt
gggttctctg tgcctctcat 44220tgtggtttat ctcaattggg ctgagagtga
ttctaggatc taaagacact gcatgactca 44280aacataagtc agctacctcc
atctagtgct caaccaaaga aatagtggtc tcttactgtt 44340aagggacgaa
gtggtttagt gagagatacc aggtcatttt cccatataca tgctttggaa
44400gcatctttca aggctaattt tggctgtata tgattttcaa ttcctgtgct
aaatttagat 44460tctagctgcc atttaagata ggactctgtg gtgtatatac
ctattccctc acagaaattc 44520agaaagtaca tagtttcata cataataaag
acatattaaa gaagcacttg agctaaagta 44580tctgtttaac tttgtagtca
actgctgctt attgtctcta caggaaagct ggttgagcag 44640aggaagcaca
ttgatgcggc catggttttg gaagagtgtg cccaggtaaa ctcaattcct
44700cccttctaaa ccccccagtc agcaagaaag gtcttctcaa ttgtatctta
gtgatcatga 44760aagttaaagg aactgtgcat aattgttaag tccagagata
gtgtttgccc cagaggtctt 44820atcttgctgg cttgacttgg aaatctaaat
ttagtacatc tctaagtttg gtgaggtaga 44880atatgaaggt gctctacttt
aacataccac tggtttgacc ttggtagaaa gtacttaatt 44940acatctcaag
gtagctgtgc tttttaaaat tgagtttgcc aaagtagaaa caatgagaaa
45000ggaccattat aaaacaggat cattgaaggc tacatactct tggcttttac
tctcattctc 45060cctattggaa atgtctcttt tacctcaggg acctggaggt
acagcagatt ataaggataa 45120gtacccatat gagcatttgg tagtattata
ggatttatta
tgaaaataat aaaactgcag 45180taacactggc cacagactaa cagtacacag
gtgcacagtt gacaccaggg attattgcct 45240tgtagagttt tgacctttga
tgagagagtg ttttttacag ttgttactga tagcacattt 45300atgtaactta
attgtgcttt aaaaatattt aattgtctct tgtgtaataa cagtaagtga
45360aagacgataa ctaaaatttt atataattag atcctggaga gaatatttgt
tgggtgattg 45420aattgaaaat accagtgaat gaaacatacc taaaagggta
gataggttgg gttggaaaga 45480tataccacat cgagggttaa ttaaatggat
aagatgtcat tatctttttt tctttgtaaa 45540ggaagattaa tgcataaaat
tattttgtgt aatttacata caataaaatt atgtgttgta 45600cagttgtata
atttacatat aataaagcta attcaccaat tttagatgaa gaattcagta
45660catttggaca tatgtttgta gctgtgtaac caccattgca ctcatgatct
agaacatttc 45720taacaccccc aaaagttccc tacttcccct tttgcagtca
gccttctccc tccactgcca 45780gcctttggca aactgatcag tcagtaaagt
ttcacattat ctagaatttc atataaacag 45840aaccatatgg tatgtagtct
ttttaatctg gctcctttca ctcacatagt gcattggaga 45900tgcatccatg
ttgtagttta ttcctttgta ttgctgaata gtatcccatt atatgtatat
45960gtcagaattt gttgatttac cagttgatgt acatttggat tgttttcagt
ttggggttat 46020tatgaataac gcagccatga acattctagt gcaggtcttt
atggggacag gagtaggaat 46080gccacatccc gtggtaagtg gatgtttaac
tttttaggaa gctgcagaac taatctgcag 46140tggccgtatc attttgcatt
cccctcagtg atatgtgaga gtgcttcagt gactcctata 46200ctcaccaaca
ctgggtgtat tactgtgaca ctagatgtat tatctattgc tacgtaacaa
46260cttaccttaa aagctggcag cttaaaacaa cagaccctat tatcccactt
tttcaatggg 46320ccaagaatct tggctgggct tagctggggc ctctggctca
gggtccttta caaggctgca 46380attaaggtat tggccagggc tagagtcatc
tcaaggcttg actagttttt aatttcattt 46440tctaatgttt tattactagt
atatagaaat atagctgaag tgttttgcag ggaggctgta 46500taattgacct
tgtatcctgc aaccttgcta aactcattta ttagttctag aagctcttgg
46560gtgtattctc taggattttc tacatcaaca aacatggttt ctataaatat
agttttatgt 46620ctttcttaca atcaatactt ttttctatct gtattgcatt
ttctagggct tccagtgtgg 46680tgttgaatag aagtgttaag agtgaacatc
cttgcctttt tcctgatatt ggagaaaatt 46740cacttgtctt ttagcattaa
gtgtcatgtt tgctttttta aaattttatt ctatattatt 46800ttatttttga
gacagagtct tgctctgtca cccaggctgg agtgcagtgg tgtgatctca
46860gctcactaca accttgacct cctaggctca agcgatcctc ccacctcagc
ctcctgagta 46920gctgggactg caggaacatg ccaccatgcc tggctaattt
ttgtattttt tgtagggatg 46980gggttttgcc atgttgccca ggctggtctt
gaactgttgg attcaagcaa ttcgcctgtc 47040tcagcctccc aaagtgctgg
gattacaggc atgagcctcc gtgcctggcc tgatatttgc 47100tttttttttt
ttttttaatg ctctctattg cagagttggc aaactacaac ctgtgacaaa
47160tccagcatgc cacctgtttt tgtaaataaa gctttattgg agcatagcca
tgctcattag 47220tttacatctt gtgtatggct gctttaacac tacagcagca
gagttagagt tgtgacacag 47280atagtttggc ccataaggcc tatatttact
gtctaatctt ttacaggaaa aatttgccaa 47340ttcctgccct cttggtttga
ggaaattccc ttctgttcct tgttctgaga gtttgtatca 47400tgaatgggtg
ttaaattttg tcaaatgcat tttcaactat gaagggtttt gtttttagac
47460gagtgatatg ggggactagg tgattgattt tctactgtta aaccaacctt
gcatctctgg 47520gttcaacccc acttggtatt atagatttat tacccttttt
ctcttgtggc agattagatc 47580tactaaaatt ttcttgagga tttttgtgtt
tgtgttcatg agggatattg tagttttttc 47640gtgtctttgc catgttttgg
gtatcaggat aatgctgctg tcattgaggg gtgacaaaaa 47700tgaggggtgg
tgtcctttac acttctgttt tctggaggat ttcatgtaga attggtatga
47760gagtctagct tatggttaaa aacctatgtg tgatgtttca gacctgacca
taaacaatta 47820cagactttac ctaggaggcc acatggggaa aagctgccct
ccctacacca gacttggcgt 47880actgccaatg cattacagtt tctaaaggga
gttgcagtca aggactcagg gccccctgtt 47940agtcatgctc ttgtaacagt
atttgcattg agagtcctgg cactttcatt cttaggtctc 48000tctatctgag
gacatgggcc aaggtcttct tcaggcacct ctgccaaggc ctgtttatgc
48060aagaaggagt ggaaaaacct tgacattttt ttccactgtg actcactacc
cagtactttt 48120ccacccttag cccccttcct ttgcacccat acccccaaga
tccatcaaac tgctaaagcc 48180tttttttcca agctccttca acagtgaacc
aaccctcatg tctgtgtgga tccagctgac 48240tcttgactag tgagttgttc
cttgggaaaa aatggaacag agagagttgg tgctttccct 48300ggttttagcc
tcttgcttat accaatgcaa tgcctgaagg cttaattcat ttttgacttg
48360ttgctttgat cagctactcc aacacctgac agctcagctc tttctcccag
ctcttgggag 48420atattttttt ctttaaatgt ttagtagaat ataccagtaa
ggccatctcg gccaggagtt 48480ttctttaatg aaagtttttc actattagtt
cagttacttt agtagacatt aacctattca 48540agtttatctg tgtcttctgg
aatgagcatt ggtagtttat gtctttcaag taatttgttc 48600atttcatcta
aattgtcaga tttattggta tgaagtgttt atagtattct cttattttac
48660tgtccgtagg gtctatggtg atgtcctgtc tttcattgta gatattgatg
tgtcttcttt 48720tttctgatta ttctggccag aggtttatca attttattga
tcttattaaa gaatgaactg 48780tttcattgtt tttctctatg atttttctgt
attctatatc attctttttt tattatttta 48840ttattttatt tgctctttat
ttttctagtt tcttaaggtg atggcttact tttatttttt 48900tcttattttt
ttcttttgtt gttgttgttt ttttaaagaa acagggtccc actcttgctc
48960aggctggagt gcagtggcac gatcatggtt cactgcagtc tcaaactcct
acattcaagc 49020tgtcctcccc cctcagcctc cagagtagtt gggattacag
gtgcatgcca ccatgcctgg 49080ctaattttta attttttttg tagagatggg
gtgttactag ttgcccacgc tggtctgaaa 49140ctcctggcct caagtgatcc
ctccacctct gcctcccaaa gtgctgggat tccatgtgta 49200agccactgtg
cctggccaag gtgatggctt aaagctattg atttgagatg attccttact
49260ttatagttta agcatataat gccataattt tcctcaagca ccgttttagt
tacgttatac 49320aaattttgaa atgttttgtt ttcatttcct aatttccctt
gtgatttctt tattgaacct 49380tggcttattt agaagtatgt ttaacttgca
gatattggag atttgccagc catctttttg 49440ttattaattt ctactttaat
tttgttgtga ttagagaaca tacattttat taatttaaat 49500ttataattta
ttttaattta taatatggtc tgttttacag aatgttgtgt gtgtatttga
49560aaataatatg aaagctacta ttattggatg gagtgttcta taaatgtcag
ttagattagg 49620ttgatcatgc tgttctagct ttttatatcc ttattgattt
cctcactact tgctctatca 49680atgactggga aagtgttgaa gtctcccagt
atttgtctat ttctcctttg attctaccag 49740tgtttgctta atgtattttg
aagctctgtt ataggtgcat acatgtttat gagtatgtta 49800tagatgtatt
cattttgata tccttctttc tctgttacta ttcctaattc tgaatttgac
49860tttaatgtta ttaatataat tcttccagcc ttctcttggt tagtcttttc
attgcatatc 49920tttttctatc cttttacttt taatctagct gaatgtagtc
tttattttga aagtgcgttc 49980cttgttgata gcattattgg ttcttttttt
tttttaaatc taatttgaca atctctgtct 50040tttaattgga gggtttagac
atttgcattg aatgtgatta ccaatatagt tagatttaaa 50100cctacagtct
tgctgtttgc tttttgtttg tttcattgat cctttgtttc ttgttttttt
50160ctttttttgc tttcctttgg atttagtatt tttcataatt ccattttacc
tccactgttg 50220gcttattagc tatacttctt catttcagta ttttagtggt
tgctgtagga tttataataa 50280atatcattaa ctgaccatat cttcagataa
tcgtatacta cttcatatat agtgtaaaaa 50340ccttacaaga gtattcactc
cataatactt tgttattgct tttgctttaa gtgatcaatg 50400attgtttaag
gaaatttttt aatgaccttt catgtttatt cttttttttt tttttccaaa
50460agattcagta ttttccgagt tttcaaaaac tgctggccac tcaaagtgga
tcaacaaaaa 50520tttaagagct aaaactgtaa aactcttgaa ggctgggcac
agaggttcat gcctgtgatt 50580ccagcacttt gagaagctga ggtgggacaa
tcacttgagc ccaggggttt gagaccagcc 50640tgggtaacat agaaagacct
tgtttctaca aaaaataaaa acacaattag ccaggcatgg 50700cggtgtgcac
ctgtagtccc aacttcttgg gaggccaagg tggcaggatt tcctgagcct
50760gtaagtttga gactgcagtg agctgagttc acgccactgc acttcagcct
ggacaacaga 50820acaagaccct gtctcaaaac cagaacgaaa ctataaaact
cttagaagaa aacagggcta 50880aatcttcatg actttggatt tggcaatgga
tggttagaat taataccaaa aacacaatca 50940ataaattgat aaattggatt
taataaaaat taagaacttt tgtgtatcaa ggacattgtc 51000aagaatgtga
aaagacagca tatagaatgg aagaagatat ttgcaaatcc tatatctgat
51060aaaggtttaa tatccagaat atgtaaggaa ctcctgcagc tcaacaacag
aaagccagtt 51120aaatcaattt tgaaatgagc aaacgcctgt aaacccagct
gcttggcaga ttgagacagg 51180aggattgctt gaggctagga gttcaagacc
aacctggaca acatagtgag accctgtcta 51240aaaacatttt tttaattagc
tgggtgtggt ggcatattcc tgtagtccca gctacatggg 51300agaccgaggc
aggaggatca cttggggcca ggcagtcaag gctgccgtga gctgtgatta
51360tgccactgca tcccagcctg ggcgacagag tgagaccctg tctgagaaaa
aaaaaaaaaa 51420aagaacaaaa aaaaatttag aagattgcta ttctagtcta
ctattttttc aaagggtggt 51480cttgttaaca attctggagc ccacctaaac
ctgctaaatc aaacttggta gtaaagctgg 51540ggagatgggc atgtctaaca
gacgtttctg gtggttttga tgtccaggcg tgcagagaga 51600tgatgcttac
cttgtgtttt gtcattattt tcaggattta caccccttcc ttgtcttttg
51660tatcaatatt tatggagtca tgaactctag gataggcatg atgttgagaa
ctaggagttc 51720tcccctggcc agggagatag aggcaggtct gtggttagtt
ttgtagttgg ctgtgatgac 51780atctgacatg ctctcttcac ttgttgtctt
cttcctgttc ccttgtcagg attatgaaga 51840agctgtgctc ttgctgttag
aaggagctgc ctgggaagaa gctttgaggc tggtaagaat 51900cttgtaaatc
ctctggatgt tgggtgctaa gcagagagag caagcaaggg attccaggtc
51960agttggaatc tcttgtcttc tgaggttcat gaaataagta gaaataggtc
aggttcctgg 52020cttaaggaaa agcggtgtta ctaaaatcat ttttatcatt
cttgataata atttgaaata 52080ttactgtctt ttactgaaat gaattgaatt
tccttggctg ccttgtagga ggcctgtttt 52140tcaggaaaat attctgatta
cctctgaaag taatccatgt ctttctaagt atcttaactc 52200tccagtgact
agaagttttc cttcctaaaa tatcgtgttt ttccttctag gtatgcaaat
52260ataacagact ggatattata gaaaccaacg taaagccttc cattttagaa
ggtgagggtt 52320ccattttaga tagaattcct catttggaag aaggtgagga
gagagagatg agagagtctc 52380ctcctattta ctgtgttttc ttaataatat
gtcatgtaga ctcaatcaaa attaccacct 52440ggatataata tttaattctc
actagaattt ttaaatatgc tgaactatta aatggtaaca 52500aaatatttaa
atgttagaaa cctgtgatca aatatgatta agaatctttg tatttggaaa
52560tagtaaactt gaatatgaac tatattagat aataatataa cactgataaa
tttctggcat 52620ttaataatca tgttgtggtt atataagata atatcctatt
attctcaaga gataaatgct 52680gaaatattta ggaatgaagg atcatatctc
tgccttactc ttaaaaggtt ccacaaaagt 52740attaatgaat gtgtgtatgc
atgcagagaa acaggaagca aaaaaatgtc aaaatgttag 52800taattggtaa
atcaaagtga agggtatatg tgtgttcatt gaactcttac aacttttatg
52860taggtttcaa cgtttcaaag tattttttaa aagttacctt ttcaaatgaa
gtttgtggtt 52920cttagagaac atatgaatat taccagttct agaatactca
gatggtcact gtgacctctt 52980aaaagcaaag tggagaagga catcagtttg
acttatagaa accttaggga gtggttgatt 53040ttaagttctg catttttatg
cacatctacc ctgtaagtaa cgtctggcct ttctgacatt 53100tacatgtatg
cacattctta ccttgtctgc acccccttcc tccatcctaa ttaaaacgtt
53160gctggggtac tttttatgtc attcacttta ggtacctcta actgggtact
gaaaacatca 53220ttcctcatct ataataatct aaccagctct tacttagatt
ttcaccacta atgagaacct 53280ttcttagata aatgccgata attcatctac
ataggcccaa aacctattaa taaaatgcat 53340ccttggatag tagtattttg
cttttttaaa atgtattcta ctagtgttat ttttctcttg 53400tgtatttttc
cattggacaa tatttattag atacattttt tccacatcca tgggcatttt
53460gatggatgtt tagccagaaa catttaggta attttcttct tatttttgtt
aactgagctc 53520ccctccccta cccccccttt ttttgtttgt ttgttttgtt
tgtttgtttg ttttgccaat 53580cctcccttgc tttaggtatc aagtcttcgt
tcaggtgatt ttacaagttc agtggtagcg 53640catattctgg gataatgttg
atgaactcta agatctggaa tctcagtctc taatttgtta 53700atgcttatta
aggaaaaaga gctcgcttgg aaaacctagt aacctctttc tttttgctga
53760attttaaccc tccttcactg ctccccgcct ttagtttttt ctctttgctt
aaacctcatg 53820ctcaaactat tttccattct gcatctccag cccagaaaaa
ttatatggca tttctggact 53880ctcagacagc cacattcagt cgccacaaga
aacgtttatt ggtagttcga gagctcaagg 53940agcaagccca gcaggcaggt
ctgggtgagt atctgcgtga aggccatcga cgtgcggggg 54000cagtggggtt
gggtaacgcc acacattgtc tagattgctt ggtgatccgc ctgcaatctg
54060attactgtgc catgggcaag tgtgaggctt ctgtggagcc ccttcagggc
cctctgtgtc 54120tgtgtttgtg tgttggtgaa gggcaggacc aagcatgaat
ggggagagct ctgccagaca 54180ttcccaccta cccccattca cccagagcag
ctgaccactt ccgtgtctaa caaaatgagt 54240ttcctcattt ccagaaaaaa
gttcaggaaa ctactgattt acattagtaa ttactgtatt 54300taatattatc
tcattcattt tgagatcaac tttgcaatca ttttcatcca tcctttgata
54360tgcaccagtt gactctagtt agttcattta ccgccctgaa agtaaaccca
cacattagca 54420ggcagtgttt tcatcggctt ctggttcttc ttttctagat
gatgaggtac cccacgggca 54480agagtcagac ctcttctctg aaactagcag
tgtcgtgagt ggcagtgaga tgagtggcaa 54540atactcccat agtaactcca
ggatatcagc gtacgtatca cattgattca gcacattgac 54600tatatcctgg
gcatataggg aaagtggaag caaatagatt ggttttctac tgggacggtg
54660tagtgggagt ggggagaata ttcttcagcg ctgtgtggaa gttgttcaga
cactttccca 54720gcatatctga gacattaaac ttggcattgg aaggttttct
tcctcagctt tgtggcttgt 54780gtgttttccc attccccacg aggcagttcc
tcccctgaat gctcagttta tattaacatc 54840tgattttatt ttttgaacaa
atgttgtgac taaattatag gcactgaaaa aatgaaaaga 54900taagcttctt
caattcaaaa tcaggattgg aagagaccat aaatgtaaaa taagtcataa
54960cacttttacc aaatatagta atttgtcaga aatatttatt cagcactcat
atggtaggtg 55020cagtagatgt taccaaaaac ttataaggag atatgagtta
taagagttta tagtcttgct 55080tgggatgtgt aaagcaatgc aagattatat
attcaaactg aattttgctt taggaattta 55140aaatggagat ctgtgaagtt
gtgtggggtc atcagcaact gcaagaaagt agccaggcaa 55200ggtagcacat
gcctgtagtc ctagctactc aggaggctta aaaatatctg tgtaatttct
55260aacaggagat catccaagaa tcgccgaaaa gcggagcgga agaagcacag
cctcaaagaa 55320ggcagtccgc tggaggacct ggccctcctg gaggcactga
gtgaagtggt gcagaacact 55380gaaaacctga aaggtatatt ctcagtcctg
atgatgattc ctgaccacaa acaatagtga 55440ataggcagta cagacaggca
gagttcagta ggtgattaag ctaccatttt cccaatttga 55500ggaaagatga
gaacttttag caggaagggt catgtctgca cacattcctg aagcagccct
55560tcttagctgg taactgagaa gccttcctcc atttggcatc cccctaactg
aactgggaga 55620gatgcttaag ccaggataaa gaattgtggg acactgcttt
ctgcgtaggc cccccagcgt 55680gcttgatttt ctttttgtag tacatgtgtt
taattattcc agcatttggg aagaaaaaag 55740ataatgtggg agaaaggacc
tgcagtggga tcatagaaat ttttggcttt ggatagaagc 55800tatgtatgat
tctgtcaatg gagctgggaa tataacttac cactctttca aatttcttct
55860ctctagatga agtataccat attttaaagg tactctttct ctttgagttt
gatgaacaag 55920gaagggaatt acagaaggcc tttgaagata cgctgcagtt
gatggaaagg tcacttccag 55980aaatttggac tcttacttac cagcagaatt
cagctacccc ggtaagtttt ctcagagacg 56040gtgtgcattt ttttcatcat
tttcatgggt tattgtattc acacaatctc caagtcaaaa 56100agttttcctg
ttcttaaaac ataagatgcc atagttaaat tatcttagca tttatgtgta
56160agctgtcagt aagatttgat atttgcctgt agagtgacta gtataccttg
gcataggtta 56220aatggactgt cattttcctt tctggatgaa gtagctgtca
tggagaaaat gggaaagtca 56280catgattgct cctggccttc aatgaggttg
gagtggggag agatggggga agatggggtc 56340agagacggcc tctcactttc
ctttcagaac tcagggatgg gatcaggctt taaagggacc 56400ccaggcaatt
gcttttcctt ttgttttatg aaaaatttga cttgtcactt ctatgttgtt
56460atgatggact ttgcgggttg tgtttaaggc tgaatcagct ttgtatcgca
gaattctagt 56520atattgtcat ctgtttatta tttatacctc tgttcactct
cttatacttc aagtctattg 56580ttaagagttt ttatttggat tcaaaaaggc
tggtgtatca gtcaagatct agaaaggaaa 56640acaaaagcct atctattatt
ttatcacaga atttaatata tggatttgtt aaataagtat 56700tagaggacta
aacaaggcaa aagggaaata cagaggaagg acattgagat agtaactgta
56760ggaagcagct ttaccctcta gctgagggaa caggaggagt tgttgggaat
tattagaatt 56820tagaagcctg gaagtggggc cctgtagagc tggctcttga
acctctgaga ggagggtgcc 56880agccagctaa tcctggcatt tctgagggag
ctggttccaa gcgtacagaa gtaaatggaa 56940actggaagga acagctgctg
ctgggggaaa agccagccgg tcgggccagg tgtggtggtg 57000gctcacgcct
gtaatcccag cactttggga ggccaaggca ggcggatcac ctgaagtcag
57060gagttcgtga ctaatgtggc caacatggag aagccccgtc tctactaaaa
atacaaaatt 57120acccgggcat ggtggcgcat gcctgtaatc ccagctactc
aggaggctga ggcaagagaa 57180tcgcttgaac ctgggagaca gaggttgtga
tgagccaaga tcgtgccatt gtactccaac 57240ctgggcagca agagcgaatc
tccgtttaaa aaaaaaaaaa aaaaagccag ccaatcacgg 57300aagaaatcta
gaaatctttt gttcatcctc cagctttgta ctccccctct ggtgttcact
57360gtaggcagga catgatggga agccagcagc aaggaagaat atctttcagg
tgcccagccc 57420cagcaccaca agcagtggat agaagggtgg gttggagctg
agagattaca aatcagctca 57480gtgtttagaa acacatacgc ttatcatgtc
ttgatttcct catttagaaa tgggcataag 57540acttctctgt gtgcttcaat
agaatgcttt gaaggttaaa taagagggtg tgtgtaaaag 57600cactttacaa
accgttgaaa taaaagcaac taggaatcag ggccccagaa cttcttgaat
57660ttattataat aggtatttct tagaagaaat gtgatcatca tcttcaaaac
tgtagtactt 57720ttgaagataa ttgtttttgt tttttgagac agggtctcac
tctgttgctc aggctggagt 57780gcagtgatca ccgctcactg cagcatccac
cgccccgggc tcaggtgatc ctcccacctc 57840agcctcttga gtagctggga
ctacaggcgc atgccacaac acctggttaa ttttcaaatt 57900ttctgtagag
acagggtgtc accaagttgt ccccgctggt cttgaacaac tcctgggctc
57960aagtggtctg cccacctcac ctctccaaag tgctgggact ataggcatca
gccaccatgc 58020ccggcttgaa gataataatt tataatacca ctcccatgag
tgatcttctc ttctgatcac 58080atattcacat taaggtctat tttattttat
ttttttcttg ctctgtcacc caggctagag 58140tgcagtgaca gtatgatcaa
tcatggcttg gtgcagcctc gaatgcctgg gctaaagcag 58200tcctcccacc
gcagtctcct gagtaattgg gaccacaggt gcacaccacc atgcccagct
58260aattttaaaa ttttttccta gacatgggga gagggagtct tgctgtgttg
cccaagctgg 58320tcttgaactc ctggcctcaa gtgatcctcc tgccttggcc
tcccaaagtg ctgagattac 58380aggtgtaagc caccatgcct cccacattaa
gttctaagac atcaatttta tgattgtggt 58440tttgattggt gaagtatggt
tgtggtatgt gcaggatacc gtgagtgact tctcatggca 58500ttgctcttga
gagtgtgcca ccaagggtct gcactaacca ggggtgtgcc cagaggctcg
58560ctgcaggctt gaaattcctg cggagtcttg tgttttacct ggagcacatg
tgcacagttt 58620ccattctgct ccatagtatg cacatgtttg tatttatttc
aacctaaaaa tgtttgtttc 58680ccataactct ttgcgtataa ttgatactct
acgtatttgt agcctctttt actcttttcc 58740ctttcctcag ggagtggttt
gctcatttag aaaaggccaa gatatatcac tgtagagttt 58800cgtttctttt
cttttcctcc accccccatc tttaccttgt tctgggagaa aggagaatta
58860gaagtctgag ttgcagctgg agaaactggc aaattaaaat cacattggga
aagagaatta 58920ctgtgtttca caccatacca gtagaaatga caggctgttt
tctgctggta gggatttggc 58980ctttggtatt ggcagtcttg agaagtatta
gataatcttt gctgatacag tctattttct 59040cctcaggttc taggtcccaa
ttctactgca aatagtatca tggcatctta tcagcaacag 59100aagacttcgg
ttcctgttct tggttagtat tttttctcat ttaatattac aatactaagc
59160agaaggacta tctttctgta agtattgaga agatcagcag tataaggaga
gattggatac 59220aatttttcac tacaaaaaat tgactacaat tcttcctcaa
ttctaagacc gcatctttag 59280tatgatcagt ttcatgcttc tagcggtggg
ggacctggtg caggaaaatc cagcatgacc 59340attgtatgtg taatttttaa
aaatatttat gtggcatatg cttgttcata aaggcacacc 59400acagttccag
tttcagtcta aactgtctac atttacatat acatcaaaag attcttctga
59460agcatcatta ctggctattg gcagttatgc tttgcatctt gggggcattt
tcataaacct 59520tgcttatgag tgggaccttt ttattatgtt taggattgac
aatataattt gaaggcaaat 59580ccaaagaata ttagcatttt atacatattt
cctgtttagt tatgcatgaa gtgttttatt 59640tgttgagggg agatgattct
caattagatt acttatttcc ctaaaaatta aaaaccctaa 59700gcgctttctt
ttgaaagttg gttagaaaca tttgatgagt cagcttggga ctttcagtat
59760ttgcccttac ttatagttgg atcaatgaag catcttagct ttgaaaagtg
aatgatagtt 59820tctaaaataa ttggcagttt taactgctat tatttgcatt
tctagcatgt gacaagcaac 59880tttctgaaat tttttttcac cgaagtgcta
cactgtaata gcattttgat gacatttgaa 59940gtagcctgtg gggattcaaa
ttaagtttga ctttaacagc ttatgttgct accaggaaga 60000acagctacct
tccatcccag ctaaactcat acatccagac tgtaactact gtattcctag
60060ctcctcttct gtctagagaa tggcaaggtt cttttggtat gcagtttcga
catatccact 60120tattcctttt tttttcttaa gttttttcat ttagaaaaaa
aaacagatgg ggtcttaata 60180tgttgcccag gctggtctca gcctcctggt
ctcaagtgat
cctcctgcct cggcctccca 60240aagtgctggg attacaggcg tctgcccctg
tgcccagccc acttatttcc cagatgctag 60300gaacttacat tagacctgag
gccatttggt cattgtttat tttgtgctgt agtccaatcc 60360agttgtgatt
tctgcctcct gtgttcctcg ttgctggcct gatgctgacc ttcaggttag
60420gtcagtccca tcattcccca gggtattcta gatggctttc ccacttcaaa
gagcactttc 60480ttgttttcca gctgagcctt aaagacactc tgtaatattt
gagagcccct cattatctga 60540gtgtttatta tcattaccct tgtggtttca
aggatgtata ggaaaaggta agttcctata 60600attcaaaaat tgccactgat
gaactaatca caaaattagt gccactcaaa tattactcag 60660ctgcccctcc
ccagctaaca atagttaagt atattggcac atccccacaa gtgaaatcaa
60720tgacttgatg ggtcatttct gattgtttcc tgctttgatg caatacaata
tcatgcagat 60780caattgcaag tcttgcaaaa atttagtatt acataaaata
gattaaaatg atattggaaa 60840agtacttgaa tcacagctgg gttggacttg
ttgcaattga tgacaaaata agtgcttcaa 60900atgattttga ctatcaaagg
attgagagag gtccttagaa aaattgaaaa gccctcaagt 60960tatttttata
aaaatggcct tttttgtgtg ctgtgaaatc cacatatgga aatgtgaaat
61020atgtcatgtc ctgctgtcat ataatttgtc agaataatta ctttcttgcc
caaaagtctg 61080tactttgtgt ttatttcaag ttaagtctag aatcaaatat
agttgtagtt atgcctaatt 61140ttaaaaaatg agatagagca cattattttt
gtaactagtt tttttttttt tttttcagac 61200agagtcttgc tctgtggccc
aggcgggagt gcagtggcgc aatctcggct cactgcaagc 61260tccgcctccc
gggttcacgc cattctcctg cctcaccctc ctgagtagct gggactacag
61320gcgcccgcca tcacgcccgg ctaatttttt tgtattttta gtagagacgg
ggtttcaccg 61380tgttagccag gatggtctcg atctcctgac ctcgtgatcc
acccgcctcg gcctcccaaa 61440gtgctgggat tacaagcgtg agccaccgcg
cccggcctgt aaatagtttt tttaagataa 61500agtcttattc caactttaat
tggaatttat gaaatacctt gttgatagtg aatttattta 61560agtagccttt
tttcagtatt gatattctta tatctttatg gcaccattta gtggagagaa
61620atgtaaacaa acataaagat gtagtattaa atcataactg cataaaatta
actgtagtat 61680gtactgcact actgtaataa ttttgtagct acctcctgtt
gctattgtgg tgagtgagct 61740caagtgttac caatatctgc ttaaaatgcc
atgtgccgct aaccatctcc acatgagcag 61800cacatgagag tctccattaa
ttgcatatgg cagcgaaaag tgatctcttg cattgtcgtg 61860tattttttat
cacgtttaat gtaatatcgt aaaccttaaa taacaccatg agacctatag
61920gaagtaccac aagtgttgct cccaggaagc agagaaaagt cataacatta
caagaaaaag 61980ttgacttgct cgatatgtac tatagattga ggtctgcagc
tgtagttgcc caccacttca 62040agataaatga acccagtgca aggactatta
taaaagaaaa ggaaatttat gaagctgtca 62100ctgcagttat gccagcaggc
atgaaaacct tgtacttttt gcaaaatacc tttttatgtt 62160gtattgaaga
tgcagctttt atgtgggtgc aggattgcta tgagaaaggc atacctatac
62220aactattatg atttgagaaa aagcacagtc attgtatgag aacttaaagc
aaaaagatga 62280aggatcaaag ctggagaatt taatgccagc aaaggatggt
ttgataattt tagaaagagg 62340tttggctttg taaatgtctg gataatagga
aaagcagctc ctgccatcca ggaggcagca 62400gcaaaggcag tcaggtttat
gatcaggact gcccttatct gtaaagctgc taacccccga 62460gcctggaagg
gaaaagatta acaccagctg ccaggctttt ggttgtacca tacaacaaga
62520aggcttggac aaggagaaca ctttttctgg attggttcca ttgtcgattt
gtccctgaag 62580ttaagtagta tcttgccagt aaggggactg ccttttaaag
ttcttttgat actggagaat 62640gcccgaggcc accccaaact ccatgagttc
aacaccgaag acattgaagt gatctacttg 62700cccccaaaca cacatctcta
attcagcctc tagatcaggg tgtcataagg acctttaagg 62760ctcgttacaa
acagtactct atagaaagga ttgtcaaatg tatggaaaag aaccttgaca
62820gaacatgaaa gtctgaaaga attacaccat caatgatgcc atcattgtta
tagaaaaagc 62880tgtgaaagcc atcaagccca ggacaataaa ttcctgctag
agaaaactgt gtccagatgt 62940gcatgacttc acaggcttta cgacagccaa
tcaaggaaat catgaaaaag attgtggatc 63000tggcacaaaa aaaaaaaaaa
aaaaaaaaaa tggtgcatga aggatttcaa gataggaatc 63060ttggagaaat
tcaagaggtg atagacatca caccggagga attaacagaa gatgacttga
63120tggagatgag tacttccaaa ccagcgccag acaatgagga agattacata
aaagaagcag 63180tgccagaaaa taaattgaca tttgttccaa aggttccaat
tattcaagac tgcctttggc 63240ttcttttaca acatggatga ttctatgtta
tgggcactga aactaaaaga aactgtggaa 63300ggattggtac cttagagaaa
tgaaaaagca aaaacatcag aaattatggt gtatttctgt 63360aaagttagtg
acactgagtg tgcccacctc tcttgcctcc tctttaacct cccctacctg
63420tttcatctct accacccctg agacagcaag accaacccct ccacttcctc
ctctacttca 63480gcctactcaa cgtggagatg acaaagatga agacctttat
gatgatccac ttccatttaa 63540tgaatagtaa atattgtttt ctttatgatt
ttcttaatat tttcttttct ctagcttact 63600ttattgtagg aatgtagtat
ataatacata taacatacaa aacatttgtt aactgacttt 63660ttatgctgcc
aatacactgc cgaacaacag taagctattg gtacttgagt tttggagatt
63720cagaagttaa acatggggcc aggtgtggtg gctcacacct gtaatcccag
cactttggga 63780ggctgaggtg ggtggaacga gaccaggagt tttgagagta
gcctgggcag catggtgaaa 63840ccttgtctct acagaaatta gccaggtatg
gtggtgtaca cttgtagtcc cagctacttg 63900ggaggctgag gcaggagaat
cgcttgaacc cagggggtcg aggctgcagt gagtcatgat 63960cgtgccactg
cactccaacc tgggcaacaa aatgagaccc tgtctcaaaa aaagaaaaaa
64020aaaaggtata tgcagatttt tgactgtgca ggggggtccg cacccataac
cctacattca 64080aggatcaact gtaatttttc atgcctgcat ggctcatatg
tacagattta ctgctggaag 64140tttatcataa ataatgctga aaaagaaaat
ccttatatat acatattttc tcctatctct 64200gcttgcagta tatgattcct
ggttagaaaa gaaacttaac aaatctaagt gaaagagtgc 64260ctgggagttt
taggttacaa tgacagaatc ttttcctaac cctctctctc cattcacttt
64320ttttaaagca ggggcatctt tattgatcaa catgtttgtc gaagtttcat
cataaagtag 64380ttcctgtcca ttaacttcac ttactgaata tgtgctatca
cattttgcta ttccttaaaa 64440attgagctag actttacata tagtgaaatg
cagagatttc aggtgtacaa tttgatgagt 64500tttaataaat gtatacagcc
atgtgactgc tgccaccacc cctcccacca gtttgaaata 64560cagaacattc
ttccactttg aatcactggg tgagcatgcc tgaggttgaa atgcagtccc
64620tcctctcagg gcggggcctc caggttgtgt ttgctctgac ctggaggttg
caggggtagc 64680agacacatga actctggctc tgatggtctt attgctgcaa
actccacctg cctagtttgt 64740ttagtttaga gttactgcct cagcgccctc
caacaagagt atgtctgtca caatttccct 64800tcctttcttg cttttagatg
ctgagctttt tataccacca aagatcaaca gaagaaccca 64860gtggaagctg
agcctgctag actgagtgac tgcagttagg agggatccga cagagaagac
64920catttccact cattcctgtt gtcctaccac cccttgctct ttgagggctg
gctattgaga 64980actggaaaga gtaaaatgat aacttacctt agcattgcca
agaacttcag cagacaacaa 65040gcaattctat ttattttatg ttgtgtatac
atcttgatca ttagcaagac attaagcttt 65100aaccattatg gcaccatttt
gtgagaatga ttgttctttc acttgggctg tttgagagca 65160taattatggt
aatcatgaga ttaatgtttc atgatttcta cctccaaagt gtgaagacaa
65220gtaaaacaat gtttctaaat tgtcttattt tgttggcgga gaagattaca
atggctatta 65280gtgctacatt tggtcaaatg taatcactta aatagcttct
tgtcacctta aactaaagca 65340gaataaaaag tatcctttga aattataagc
cctcctttgc tgacagctat tattttgtaa 65400catcttacca ggtcatgtgc
tttcagttat aactgggctg agcctcctat aattacaatg 65460tctataggga
ctgttttact gcctgtgtat tttctgctag agagttagca atgttagagc
65520tagaacagat tagaatttct aaacagtatc atgcacagtt ggtgtgagtg
atcagtgtgc 65580attgtatggc atgcatggtt gtgaattatt ctctgttctc
caaatactgt ttctttaact 65640cagatatttt tgttagtgtc taggccactt
catttatttt tcgtcatggt actttactga 65700cttctcttta ttcaattctc
cacgccctca ccaaaaaaaa ctgtctcaaa atgagaatat 65760tttattttca
tggtgagtct agaaaacgcc cacttcattc tgattaaaaa ttcttccatg
65820ttttaaatat cagaaccaga cctttcttac tgtgtatctt agcccatttg
tgtctctata 65880acaacaacca gctttcaaag gaactaatag agtgaaaact
cactcattac cacgaggatg 65940gcacaagcga ttcacgtagg atctgcccct
gtgaccaaaa cacctcccat tgggccccac 66000ttccaacact ggtgatcaca
tttcaacatg aggtttaggg aaacaaatgc ctaaactaca 66060gcactgtaca
taaactaaca ggaaatgctg cttttgatcc tcaaagaagt gatatagcca
66120aaattgtaat ttaagaagcc tttcccagta tagcaagatg ttaactatag
aatcaatcta 66180ggagtattca ctgtaaaatt caacttttct gtatgtttga
acattttcac aatctcatag 66240gagtttttaa aaagaagaga aagaagatat
actttgcttt ggagaaatct actttttgac 66300ttacatgggt ttgctgtaat
taagtgccca atattgaaag gctgcaagta ctttgtaatc 66360actctttggc
atgggtaaat aagcatggta acttatattg aaatatagtg ctcttgcttt
66420ggataactgt aaagggaccc atgctgatag actggaaata gaagtaaatg
tgtttattg 6647925924DNAHomo sapiens 2ccagtgctgg ggctgcctag
ttgacgcacc cattgagtcg ctggcttctt tgcagcgctt 60cagcgttttc ccctggaggg
cgcctccatc cttggaggcc tagtgccgtc ggagagagag 120cgggagccgc
ggacagagac gcgtgcgcaa ttcggagccg actctgggtg cggactgtgg
180gagctgactc tgggtagccg gctgcgcgtg gctggggagg cgaggccgga
cgcacctctg 240tttgggggtc ctcagagatt aatgattcat caagggatag
ttgtactgtt ctcgtgggaa 300tcacttcatc atgcgaaatc tgaaattatt
tcggaccctg gagttcaggg atattcaagg 360tccagggaat cctcagtgct
tctctctccg aactgaacag gggacggtgc tcattggttc 420agaacatggc
ctgatagaag tagaccctgt ctcaagagaa gtgaaaaatg aagtttcttt
480ggtggcagaa ggctttctcc cagaggatgg aagtggccgc attgttggtg
ttcaggactt 540gctggatcag gagtctgtgt gtgtggccac agcctctgga
gacgtcatac tctgcagtct 600cagcacacaa cagctggagt gtgttgggag
tgtagccagt ggtatctctg ttatgagttg 660gagtcctgac caagagctgg
tgcttcttgc cacaggtcaa cagaccctga ttatgatgac 720aaaagatttt
gagccaatcc tggagcagca gatccatcag gatgattttg gtgaaagcaa
780gtttatcact gttggatggg gtaggaagga gacacagttc catggatcag
aaggcagaca 840agcagctttt cagatgcaaa tgcatgagtc tgctttgccc
tgggatgacc atagaccaca 900agttacctgg cggggggatg gacagttttt
tgctgtgagt gttgtttgcc cagaaacagg 960ggctcggaag gtcagagtgt
ggaaccgaga gtttgctttg cagtcaacca gtgagcctgt 1020ggcaggactg
ggaccagccc tggcttggaa accctcaggc agtttgattg catctacaca
1080agataaaccc aaccagcagg atattgtgtt ttttgagaaa aatggactcc
ttcatggaca 1140ctttacactt cccttcctta aagatgaggt taaggtaaat
gacttgctct ggaatgcaga 1200ttcctctgtg cttgcagtct ggctggaaga
ccttcagaga gaagaaagct ccattccgaa 1260aacctgtgtt cagctctgga
ctgttggaaa ctatcactgg tatctcaagc aaagtttatc 1320cttcagcacc
tgtgggaaga gcaagattgt gtctctgatg tgggaccctg tgaccccata
1380ccggctgcat gttctctgtc agggctggca ttacctcgcc tatgattggc
actggacgac 1440tgaccggagc gtgggagata attcaagtga cttgtccaat
gtggctgtca ttgatggaaa 1500cagggtgttg gtgacagtct tccggcagac
tgtggttccg cctcccatgt gcacctacca 1560actgctgttc ccacaccctg
tgaatcaagt cacattctta gcacaccctc aaaagagtaa 1620tgaccttgct
gttctagatg ccagtaacca gatttctgtt tataaatgtg gtgattgtcc
1680aagtgctgac cctacagtga aactgggagc tgtgggtgga agtggattta
aagtttgcct 1740tagaactcct catttggaaa agagatacaa aatccagttt
gagaataatg aagatcaaga 1800tgtaaacccg ctgaaactag gccttctcac
ttggattgaa gaagacgtct tcctggctgt 1860aagccacagt gagttcagcc
cccggtctgt cattcaccat ttgactgcag cttcttctga 1920gatggatgaa
gagcatggac agctcaatgt cagttcatct gcagcggtgg atggggtcat
1980aatcagtcta tgttgcaatt ccaagaccaa gtcagtagta ttacagctgg
ctgatggcca 2040gatatttaag tacctttggg agtcaccttc tctggctatt
aaaccatgga agaactctgg 2100tggatttcct gttcggtttc cttatccatg
cacccagacc gaattggcca tgattggaga 2160agaggaatgt gtccttggtc
tgactgacag gtgtcgcttt ttcatcaatg acattgaggt 2220tgcgtcaaat
atcacgtcat ttgcagtata tgatgagttt ttattgttga caacccattc
2280ccatacctgc cagtgttttt gcctgaggga tgcttcattt aaaacattac
aggccggcct 2340gagcagcaat catgtgtccc atggggaagt tctgcggaaa
gtggagaggg gttcacggat 2400tgtcactgtt gtgccccagg acacaaagct
tgtattacag atgccaaggg gaaacttaga 2460agttgttcat catcgagccc
tggttttagc tcagattcgg aagtggttgg acaaacttat 2520gtttaaagag
gcatttgaat gcatgagaaa gctgagaatc aatctcaatc tgatttatga
2580tcataaccct aaggtgtttc ttggaaatgt ggaaaccttc attaaacaga
tagattctgt 2640gaatcatatt aacttgtttt ttacagaatt gaaagaagaa
gatgtcacga agaccatgta 2700ccctgcacca gttaccagca gtgtctacct
gtccagggat cctgacggga ataaaataga 2760ccttgtctgc gatgctatga
gagcagtcat ggagagcata aatcctcata aatactgcct 2820atccatactt
acatctcatg taaagaagac aaccccagaa ctggaaattg tactgcaaaa
2880agtacacgag cttcaaggaa atgctccctc tgatcctgat gctgtgagtg
ctgaagaggc 2940cttgaaatat ttgctgcatc tggtagatgt taatgaatta
tatgatcatt ctcttggcac 3000ctatgacttt gatttggtcc tcatggtagc
tgagaagtca cagaaggatc ccaaagaata 3060tcttccattt cttaatacac
ttaagaaaat ggaaactaat tatcagcggt ttactataga 3120caaatacttg
aaacgatatg aaaaagccat tggccacctc agcaaatgtg gacctgagta
3180cttcccagaa tgcttaaact tgataaaaga taaaaacttg tataacgaag
ctctgaagtt 3240atattcacca agctcacaac agtaccagga tatcagcatt
gcttatgggg agcacctgat 3300gcaggagcac atgtatgagc cagcggggct
catgtttgcc cgttgcggtg cccacgagaa 3360agctctctca gcctttctca
catgtggcaa ctggaagcaa gccctctgtg tggcagccca 3420gcttaacttt
accaaagacc agctggtggg cctcggcaga actctggcag gaaagctggt
3480tgagcagagg aagcacattg atgcggccat ggttttggaa gagagtgccc
aggattatga 3540agaagctgtg ctcttgctgt tagaaggagc tgcctgggaa
gaagctttga ggctggtata 3600caaatataac agactggata ttatagaaac
caacgtaaag ccttccattt tagaagccca 3660gaaaaattat atggcatttc
tggactctca gacagccaca ttcagtcgcc acaagaaacg 3720tttattggta
gttcgagagc tcaaggagca agcccagcag gcaggtctgg atgatgaggt
3780accccacggg caagagtcag acctcttctc tgaaactagc agtgtcgtga
gtggcagtga 3840gatgagtggc aaatactccc atagtaactc caggatatca
gcgagatcat ccaagaatcg 3900ccgaaaagcg gagcggaaga agcacagcct
caaagaaggc agtccgctgg aggacctggc 3960cctcctggag gcactgagtg
aagtggtgca gaacactgaa aacctgaaag atgaagtata 4020ccatatttta
aaggtactct ttctctttga gtttgatgaa caaggaaggg aattacagaa
4080ggcctttgaa gatacgctgc agttgatgga aaggtcactt ccagaaattt
ggactcttac 4140ttaccagcag aattcagcta ccccggttct aggtcccaat
tctactgcaa atagtatcat 4200ggcatcttat cagcaacaga agacttcggt
tcctgttctt gatgctgagc tttttatacc 4260accaaagatc aacagaagaa
cccagtggaa gctgagcctg ctagactgag tgactgcagt 4320taggagggat
ccgacagaga agaccatttc cactcattcc tgttgtccta ccaccccttg
4380ctctttgagg gctggctatt gagaactgga aagagtaaaa tgataactta
ccttagcatt 4440gccaagaact tcagcagaca acaagcaatt ctatttattt
tatgttgtgt atacatcttg 4500atcattagca agacattaag ctttaaccat
tatggcacca ttttgtgaga atgattgttc 4560tttcacttgg gctgtttgag
agcataatta tggtaatcat gagattaatg tttcatgatt 4620tctacctcca
aagtgtgaag acaagtaaaa caatgtttct aaattgtctt attttgttgg
4680cggagaagat tacaatggct attagtgcta catttggtca aatgtaatca
cttaaatagc 4740ttcttgtcac cttaaactaa agcagaataa aaagtatcct
ttgaaattat aagccctcct 4800ttgctgacag ctattatttt gtaacatctt
accaggtcat gtgctttcag ttataactgg 4860gctgagcctc ctataattac
aatgtctata gggactgttt tactgcctgt gtattttctg 4920ctagagagtt
agcaatgtta gagctagaac agattagaat ttctaaacag tatcatgcac
4980agttggtgtg agtgatcagt gtgcattgta tggcatgcat ggttgtgaat
tattctctgt 5040tctccaaata ctgtttcttt aactcagata tttttgttag
tgtctaggcc acttcattta 5100tttttcgtca tggtacttta ctgacttctc
tttattcaat tctccacgcc ctcaccaaaa 5160aaaactgtct caaaatgaga
atatttttat tcttcatggt gagtctagaa aacgccccac 5220ttcattctga
ttaaaaaatt cttccatgtt tttaaatatc agaaccagac ctttcttact
5280gtgtatctta gcccatttgt gtctctataa caacaaccag ctttcaaagg
aactaataga 5340gtgaaaactc actcattacc acgaggatgg cacaagcgat
tcacgtagga tctgcccctg 5400tgaccaaaac acctcccatt gggccccact
tccaacactg gtgatcacat ttcaacatga 5460ggtttaggga aacaaatgcc
taaactacag cactgtacat aaactaacag gaaatgctgc 5520ttttgatcct
caaagaagtg atatagccaa aattgtaatt taagaagcct ttgtcagtat
5580agcaagatgt taactataga atcaatctag gagtattcac tgtaaaattc
aacttttctg 5640tatgtttgaa cattttcaca atctcatagg agtttttaaa
aagaagagaa agaagatata 5700ctttgctttg gagaaatcta ctttttgact
tacatgggtt tgctgtaatt aagtgcccaa 5760tattgaaagg ctgcaagtac
tttgtaatca ctctttggca tgggtaaata agcatggtaa 5820cttatattga
aatatagtgc tcttgctttg gataactgta aagggaccca tgctgataga
5880ctggaaatag aagtaaatgt gtttattgaa aaaaaaaaaa aaaa
592431332PRTHomo sapiens 3Met Arg Asn Leu Lys Leu Phe Arg Thr Leu
Glu Phe Arg Asp Ile Gln 1 5 10 15 Gly Pro Gly Asn Pro Gln Cys Phe
Ser Leu Arg Thr Glu Gln Gly Thr 20 25 30 Val Leu Ile Gly Ser Glu
His Gly Leu Ile Glu Val Asp Pro Val Ser 35 40 45 Arg Glu Val Lys
Asn Glu Val Ser Leu Val Ala Glu Gly Phe Leu Pro 50 55 60 Glu Asp
Gly Ser Gly Arg Ile Val Gly Val Gln Asp Leu Leu Asp Gln 65 70 75
80Glu Ser Val Cys Val Ala Thr Ala Ser Gly Asp Val Ile Leu Cys Ser
85 90 95 Leu Ser Thr Gln Gln Leu Glu Cys Val Gly Ser Val Ala Ser
Gly Ile 100 105 110 Ser Val Met Ser Trp Ser Pro Asp Gln Glu Leu Val
Leu Leu Ala Thr 115 120 125 Gly Gln Gln Thr Leu Ile Met Met Thr Lys
Asp Phe Glu Pro Ile Leu 130 135 140 Glu Gln Gln Ile His Gln Asp Asp
Phe Gly Glu Ser Lys Phe Ile Thr 145 150 155 160Val Gly Trp Gly Arg
Lys Glu Thr Gln Phe His Gly Ser Glu Gly Arg 165 170 175 Gln Ala Ala
Phe Gln Met Gln Met His Glu Ser Ala Leu Pro Trp Asp 180 185 190 Asp
His Arg Pro Gln Val Thr Trp Arg Gly Asp Gly Gln Phe Phe Ala 195 200
205 Val Ser Val Val Cys Pro Glu Thr Gly Ala Arg Lys Val Arg Val Trp
210 215 220 Asn Arg Glu Phe Ala Leu Gln Ser Thr Ser Glu Pro Val Ala
Gly Leu 225 230 235 240Gly Pro Ala Leu Ala Trp Lys Pro Ser Gly Ser
Leu Ile Ala Ser Thr 245 250 255 Gln Asp Lys Pro Asn Gln Gln Asp Ile
Val Phe Phe Glu Lys Asn Gly 260 265 270 Leu Leu His Gly His Phe Thr
Leu Pro Phe Leu Lys Asp Glu Val Lys 275 280 285 Val Asn Asp Leu Leu
Trp Asn Ala Asp Ser Ser Val Leu Ala Val Arg 290 295 300 Leu Glu Asp
Leu Gln Arg Glu Lys Ser Ser Ile Pro Lys Thr Cys Val 305 310 315
320Gln Leu Trp Thr Val Gly Asn Tyr His Trp Tyr Leu Lys Gln Ser Leu
325 330 335 Ser Phe Ser Thr Cys Gly Lys Ser Lys Ile Val Ser Leu Met
Trp Asp 340 345 350 Pro Val Thr Pro Tyr Arg Leu His Val Leu Cys Gln
Gly Trp His Tyr 355 360 365 Leu Ala Tyr Asp Trp His Trp Thr Thr Asp
Arg Ser Val Gly Asp Asn 370 375 380 Ser Ser Asp Leu Ser Asn Val Ala
Val Ile Asp Gly Asn Arg Val Leu 385 390 395 400Val Thr Val Phe Arg
Gln Thr Val Val Pro Pro Pro Met Cys Thr Tyr 405 410 415 Gln Leu Leu
Phe Pro His Pro Val Asn Gln Val Thr Phe Leu Ala His 420 425 430
Pro
Gln Lys Ser Asn Asp Leu Ala Val Leu Asp Ala Ser Asn Gln Ile 435 440
445 Ser Val Tyr Lys Cys Gly Asp Cys Pro Ser Ala Asp Pro Thr Val Lys
450 455 460 Leu Gly Ala Val Gly Gly Ser Gly Phe Lys Val Cys Leu Arg
Thr Pro 465 470 475 480His Leu Glu Lys Arg Tyr Lys Ile Gln Phe Glu
Asn Asn Glu Asp Gln 485 490 495 Asp Val Asn Pro Leu Lys Leu Gly Leu
Leu Thr Trp Ile Glu Glu Asp 500 505 510 Val Phe Leu Ala Val Ser His
Ser Glu Phe Ser Pro Arg Ser Val Ile 515 520 525 His His Leu Thr Ala
Ala Ser Ser Glu Met Asp Glu Glu His Gly Gln 530 535 540 Leu Asn Val
Ser Ser Ser Ala Ala Val Asp Gly Val Ile Ile Ser Leu 545 550 555
560Cys Cys Asn Ser Lys Thr Lys Ser Val Val Leu Gln Leu Ala Asp Gly
565 570 575 Gln Ile Phe Lys Tyr Leu Trp Glu Ser Pro Ser Leu Ala Ile
Lys Pro 580 585 590 Trp Lys Asn Ser Gly Gly Phe Pro Val Arg Phe Pro
Tyr Pro Cys Thr 595 600 605 Gln Thr Glu Leu Ala Met Ile Gly Glu Glu
Glu Cys Val Leu Gly Leu 610 615 620 Thr Asp Arg Cys Arg Phe Phe Ile
Asn Asp Ile Glu Val Ala Ser Asn 625 630 635 640Ile Thr Ser Phe Ala
Val Tyr Asp Glu Phe Leu Leu Leu Thr Thr His 645 650 655 Ser His Thr
Cys Gln Cys Phe Cys Leu Arg Asp Ala Ser Phe Lys Thr 660 665 670 Leu
Gln Ala Gly Leu Ser Ser Asn His Val Ser His Gly Glu Val Leu 675 680
685 Arg Lys Val Glu Arg Gly Ser Arg Ile Val Thr Val Val Pro Gln Asp
690 695 700 Thr Lys Leu Val Leu Gln Met Pro Arg Gly Asn Leu Glu Val
Val His 705 710 715 720His Arg Ala Leu Val Leu Ala Gln Ile Arg Lys
Trp Leu Asp Lys Leu 725 730 735 Met Phe Lys Glu Ala Phe Glu Cys Met
Arg Lys Leu Arg Ile Asn Leu 740 745 750 Asn Pro Ile Tyr Asp His Asn
Pro Lys Val Phe Leu Gly Asn Val Glu 755 760 765 Thr Phe Ile Lys Gln
Ile Asp Ser Val Asn His Ile Asn Leu Phe Phe 770 775 780 Thr Glu Leu
Lys Glu Glu Asp Val Thr Lys Thr Met Tyr Pro Ala Pro 785 790 795
800Val Thr Ser Ser Val Tyr Leu Ser Arg Asp Pro Asp Gly Asn Lys Ile
805 810 815 Asp Leu Val Cys Asp Ala Met Arg Ala Val Met Glu Ser Ile
Asn Pro 820 825 830 His Lys Tyr Cys Leu Ser Ile Leu Thr Ser His Val
Lys Lys Thr Thr 835 840 845 Pro Glu Leu Glu Ile Val Leu Gln Lys Val
His Glu Leu Gln Gly Asn 850 855 860 Ala Pro Ser Asp Pro Asp Ala Val
Ser Ala Glu Glu Ala Leu Lys Tyr 865 870 875 880Leu Leu His Leu Val
Asp Val Asn Glu Leu Tyr Asp His Ser Leu Gly 885 890 895 Thr Tyr Asp
Phe Asp Leu Val Leu Met Val Ala Glu Lys Ser Gln Lys 900 905 910 Asp
Pro Lys Glu Tyr Leu Pro Phe Leu Asn Thr Leu Lys Lys Met Glu 915 920
925 Thr Asn Tyr Gln Arg Phe Thr Ile Asp Lys Tyr Leu Lys Arg Tyr Glu
930 935 940 Lys Ala Ile Gly His Leu Ser Lys Cys Gly Pro Glu Tyr Phe
Pro Glu 945 950 955 960Cys Leu Asn Leu Ile Lys Asp Lys Asn Leu Tyr
Asn Glu Ala Leu Lys 965 970 975 Leu Tyr Ser Pro Ser Ser Gln Gln Tyr
Gln Asp Ile Ser Ile Ala Tyr 980 985 990 Gly Glu His Leu Met Gln Glu
His Met Tyr Glu Pro Ala Gly Leu Met 995 1000 1005 Phe Ala Arg Cys
Gly Ala His Glu Lys Ala Leu Ser Ala Phe Leu Thr 1010 1015 1020 Cys
Gly Asn Trp Lys Gln Ala Leu Cys Val Ala Ala Gln Leu Asn Phe 1025
1030 1035 1040Thr Lys Asp Gln Leu Val Gly Leu Gly Arg Thr Leu Ala
Gly Lys Leu 1045 1050 1055 Val Glu Gln Arg Lys His Ile Asp Ala Ala
Met Val Leu Glu Glu Ser 1060 1065 1070 Ala Gln Asp Tyr Glu Glu Ala
Val Leu Leu Leu Leu Glu Gly Ala Ala 1075 1080 1085 Trp Glu Glu Ala
Leu Arg Leu Val Tyr Lys Tyr Asn Arg Leu Asp Ile 1090 1095 1100 Ile
Glu Thr Asn Val Lys Pro Ser Ile Leu Glu Ala Gln Lys Asn Tyr 1105
1110 1115 1120Met Ala Phe Leu Asp Ser Gln Thr Ala Thr Phe Ser Arg
His Lys Lys 1125 1130 1135 Arg Leu Leu Val Val Arg Glu Leu Lys Glu
Gln Ala Gln Gln Ala Gly 1140 1145 1150 Leu Asp Asp Glu Val Pro His
Gly Gln Glu Ser Asp Leu Phe Ser Glu 1155 1160 1165 Thr Ser Ser Val
Val Ser Gly Ser Glu Met Ser Gly Lys Tyr Ser His 1170 1175 1180 Ser
Asn Ser Arg Ile Ser Ala Arg Ser Ser Lys Asn Arg Arg Lys Ala 1185
1190 1195 1200Glu Arg Lys Lys His Ser Leu Lys Glu Gly Ser Pro Leu
Glu Asp Leu 1205 1210 1215 Ala Leu Leu Glu Ala Leu Ser Glu Val Val
Gln Asn Thr Glu Asn Leu 1220 1225 1230 Lys Asp Glu Val Tyr His Ile
Leu Lys Val Leu Phe Leu Phe Glu Phe 1235 1240 1245 Asp Glu Gln Gly
Arg Glu Leu Gln Lys Ala Phe Glu Asp Thr Leu Gln 1250 1255 1260 Leu
Met Glu Arg Ser Leu Pro Glu Ile Trp Thr Leu Thr Tyr Gln Gln 1265
1270 1275 1280Asn Ser Ala Thr Pro Val Leu Gly Pro Asn Ser Thr Ala
Asn Ser Ile 1285 1290 1295 Met Ala Ser Tyr Gln Gln Gln Lys Thr Ser
Val Pro Val Leu Asp Ala 1300 1305 1310 Glu Leu Phe Ile Pro Pro Lys
Ile Asn Arg Arg Thr Gln Trp Lys Leu 1315 1320 1325 Ser Leu Leu Asp
1330 41332PRTMus musculus 4Met Arg Asn Leu Lys Leu His Arg Thr Leu
Glu Phe Arg Asp Ile Gln 1 5 10 15 Ala Pro Gly Lys Pro Gln Cys Phe
Cys Leu Arg Ala Glu Gln Gly Thr 20 25 30 Val Leu Ile Gly Ser Glu
Arg Gly Leu Thr Glu Val Asp Pro Val Arg 35 40 45 Arg Glu Val Lys
Thr Glu Ile Ser Leu Val Ala Glu Gly Phe Leu Pro 50 55 60 Glu Asp
Gly Ser Gly Cys Ile Val Gly Ile Gln Asp Leu Leu Asp Gln 65 70 75
80Glu Ser Val Cys Val Ala Thr Ala Ser Gly Asp Val Ile Val Cys Asn
85 90 95 Leu Ser Thr Gln Gln Leu Glu Cys Val Gly Ser Val Ala Ser
Gly Ile 100 105 110 Ser Val Met Ser Trp Ser Pro Asp Gln Glu Leu Leu
Leu Leu Ala Thr 115 120 125 Ala Gln Gln Thr Leu Ile Met Met Thr Lys
Asp Phe Glu Val Ile Ala 130 135 140 Glu Glu Gln Ile His Gln Asp Asp
Phe Gly Glu Gly Lys Phe Val Thr 145 150 155 160Val Gly Trp Gly Ser
Lys Gln Thr Gln Phe His Gly Ser Glu Gly Arg 165 170 175 Pro Thr Ala
Phe Pro Val Gln Leu Pro Glu Asn Ala Leu Pro Trp Asp 180 185 190 Asp
Arg Arg Pro His Ile Thr Trp Arg Gly Asp Gly Gln Tyr Phe Ala 195 200
205 Val Ser Val Val Cys Arg Gln Thr Glu Ala Arg Lys Ile Arg Val Trp
210 215 220 Asn Arg Glu Phe Ala Leu Gln Ser Thr Ser Glu Ser Val Pro
Gly Leu 225 230 235 240Gly Pro Ala Leu Ala Trp Lys Pro Ser Gly Ser
Leu Ile Ala Ser Thr 245 250 255 Gln Asp Lys Pro Asn Gln Gln Asp Val
Val Phe Phe Glu Lys Asn Gly 260 265 270 Leu Leu His Gly His Phe Thr
Leu Pro Phe Leu Lys Asp Glu Val Lys 275 280 285 Val Asn Asp Leu Leu
Trp Asn Ala Asp Ser Ser Val Leu Ala Ile Trp 290 295 300 Leu Glu Asp
Leu Pro Lys Glu Asp Ser Ser Thr Leu Lys Ser Tyr Val 305 310 315
320Gln Leu Trp Thr Val Gly Asn Tyr His Trp Tyr Leu Lys Gln Ser Leu
325 330 335 Pro Phe Ser Thr Thr Gly Lys Asn Gln Ile Val Ser Leu Leu
Trp Asp 340 345 350 Pro Val Thr Pro Cys Arg Leu His Val Leu Cys Thr
Gly Trp Arg Tyr 355 360 365 Leu Cys Cys Asp Trp His Trp Thr Thr Asp
Arg Ser Ser Gly Asn Ser 370 375 380 Ala Asn Asp Leu Ala Asn Val Ala
Val Ile Asp Gly Asn Arg Val Leu 385 390 395 400Val Thr Val Phe Arg
Gln Thr Val Val Pro Pro Pro Met Cys Thr Tyr 405 410 415 Arg Leu Leu
Ile Pro His Pro Val Asn Gln Val Ile Phe Ser Ala His 420 425 430 Leu
Gly Asn Asp Leu Ala Val Leu Asp Ala Ser Asn Gln Ile Ser Val 435 440
445 Tyr Lys Cys Gly Asp Lys Pro Asn Met Asp Ser Thr Val Lys Leu Gly
450 455 460 Ala Val Gly Gly Asn Gly Phe Lys Val Pro Leu Thr Thr Pro
His Leu 465 470 475 480Glu Lys Arg Tyr Ser Ile Gln Phe Gly Asn Asn
Glu Glu Glu Glu Glu 485 490 495 Glu Asp Phe Ala Leu Gln Leu Ser Phe
Leu Thr Trp Val Glu Asp Asp 500 505 510 Thr Phe Leu Ala Ile Ser Tyr
Ser His Ser Ser Ser Gln Ser Ile Ile 515 520 525 His His Leu Thr Val
Thr His Ser Glu Val Asp Glu Glu Gln Gly Gln 530 535 540 Leu Asp Val
Ser Ser Ser Val Thr Val Asp Gly Val Val Ile Gly Leu 545 550 555
560Cys Cys Cys Ser Lys Thr Lys Ser Leu Ala Val Gln Leu Ala Asp Gly
565 570 575 Gln Val Leu Lys Ile Leu Trp Glu Ser Pro Ser Leu Ala Val
Glu Pro 580 585 590 Trp Lys Asn Ser Glu Gly Ile Pro Val Arg Phe Val
His Pro Cys Thr 595 600 605 Gln Met Glu Val Ala Thr Ile Gly Gly Glu
Glu Cys Val Leu Gly Leu 610 615 620 Thr Asp Arg Cys Arg Phe Phe Ile
Leu Val Thr Glu Val Ala Ser Asn 625 630 635 640Ile Thr Ser Phe Ala
Val Cys Asp Asp Phe Leu Leu Val Thr Thr His 645 650 655 Ser His Thr
Cys Gln Gly Phe Ser Leu Ser Gly Ala Ser Leu Lys Met 660 665 670 Leu
Gln Ala Ala Leu Ser Gly Ser His Glu Ala Ser Gly Glu Ile Leu 675 680
685 Arg Lys Val Val Trp Gly Ser Arg Ile Val Thr Val Val Pro Gln Asp
690 695 700 Thr Lys Leu Ile Leu Gln Met Pro Arg Gly Asn Leu Glu Val
Val His 705 710 715 720His Arg Ala Leu Val Leu Ala Gln Ile Arg Lys
Trp Leu Asp Lys Leu 725 730 735 Met Phe Lys Glu Ala Phe Glu Cys Met
Arg Lys Leu Arg Ile Asn Leu 740 745 750 Asn Leu Ile His Asp His Asn
Pro Lys Val Phe Leu Glu Asn Val Glu 755 760 765 Thr Phe Val Phe Gln
Ile Asp Ser Val Asn His Ile Asn Leu Phe Phe 770 775 780 Thr Glu Leu
Arg Glu Glu Asp Val Thr Lys Thr Met Tyr Pro Pro Pro 785 790 795
800Ile Thr Lys Ser Val Gln Val Ser Thr His Pro Asp Gly Lys Lys Leu
805 810 815 Asp Leu Ile Cys Asp Ala Met Arg Ala Ala Met Glu Ala Ile
Asn Pro 820 825 830 Arg Lys Phe Cys Leu Ser Ile Leu Thr Ser His Val
Lys Lys Thr Thr 835 840 845 Pro Glu Leu Glu Ile Val Leu Gln Lys Val
Gln Glu Leu Gln Gly Asn 850 855 860 Leu Pro Phe Asp Pro Glu Ser Val
Ser Val Glu Glu Ala Leu Lys Tyr 865 870 875 880Leu Leu Leu Leu Val
Asp Val Asn Glu Leu Phe Asn His Ser Leu Gly 885 890 895 Thr Tyr Asp
Phe Asn Leu Val Leu Met Val Ala Glu Lys Ser Gln Lys 900 905 910 Asp
Pro Lys Glu Tyr Leu Pro Phe Leu Asn Thr Leu Lys Lys Met Glu 915 920
925 Thr Asn Tyr Gln Arg Phe Thr Ile Asp Lys Tyr Leu Lys Arg Tyr Glu
930 935 940 Lys Ala Leu Gly His Leu Ser Lys Cys Gly Pro Glu Tyr Phe
Thr Glu 945 950 955 960Cys Leu Asn Leu Ile Lys Asp Lys Asn Leu Tyr
Lys Glu Ala Leu Lys 965 970 975 Leu Tyr Arg Pro Asp Ser Pro Gln Tyr
Gln Ala Val Ser Met Ala Tyr 980 985 990 Gly Glu His Leu Met Gln Glu
His Leu Tyr Glu Pro Ala Gly Leu Val 995 1000 1005 Phe Ala Arg Cys
Gly Ala Gln Glu Lys Ala Leu Glu Ala Phe Leu Ala 1010 1015 1020 Cys
Gly Ser Trp Gln Gln Ala Leu Cys Val Ala Ala Gln Leu Gln Met 1025
1030 1035 1040Ser Lys Asp Lys Val Ala Gly Leu Ala Arg Thr Leu Ala
Gly Lys Leu 1045 1050 1055 Val Glu Gln Arg Lys His Ser Glu Ala Ala
Thr Val Leu Glu Gln Tyr 1060 1065 1070 Ala Gln Asp Tyr Glu Glu Ala
Val Leu Leu Leu Leu Glu Gly Ser Ala 1075 1080 1085 Trp Glu Glu Ala
Leu Arg Leu Val Tyr Lys Tyr Asp Arg Val Asp Ile 1090 1095 1100 Ile
Glu Thr Ser Ile Lys Pro Ser Ile Leu Glu Ala Gln Lys Asn Tyr 1105
1110 1115 1120Met Asp Phe Leu Asp Ser Glu Thr Ala Thr Phe Ile Arg
His Lys Asn 1125 1130 1135 Arg Leu Gln Val Val Arg Ala Leu Arg Arg
Gln Ala Pro Gln Val His 1140 1145 1150 Val Asp His Glu Val Ala His
Gly Pro Glu Ser Asp Leu Phe Ser Glu 1155 1160 1165 Thr Ser Ser Ile
Met Ser Gly Ser Glu Met Ser Gly Arg Tyr Ser His 1170 1175 1180 Ser
Asn Ser Arg Ile Ser Ala Arg Ser Ser Lys Asn Arg Arg Lys Ala 1185
1190 1195 1200Glu Arg Lys Lys His Ser Leu Lys Glu Gly Ser Pro Leu
Glu Gly Leu 1205 1210 1215 Ala Leu Leu Glu Ala Leu Ser Glu Val Val
Gln Ser Val Glu Lys Leu 1220 1225 1230 Lys Asp Glu Val Arg Ala Ile
Leu Lys Val Leu Phe Leu Phe Glu Phe 1235 1240 1245 Glu Glu Gln Ala
Lys Glu Leu Gln Arg Ala Phe Glu Ser Thr Leu Gln 1250 1255 1260 Leu
Met Glu Arg Ala Val Pro Glu Ile Trp Thr Pro Ala Gly Gln Gln 1265
1270 1275 1280Ser Ser Thr Thr Pro Val Leu Gly Pro Ser Ser Thr Ala
Asn Ser Ile 1285 1290 1295 Thr Ala Ser Tyr Gln Gln Gln Lys Thr Cys
Val Pro Ala Leu Asp Ala 1300 1305 1310 Gly Val Tyr Met Pro Pro Lys
Met Asp Pro Arg Ser Gln Trp Lys Leu 1315 1320 1325 Ser Leu Leu Glu
1330 51332PRTHomo sapiens 5Met Arg Asn Leu Lys Leu Phe Arg Thr Leu
Glu Phe Arg Asp Ile Gln 1 5 10 15 Gly Pro Gly Asn Pro Gln Cys Phe
Ser Leu Arg Thr Glu Gln Gly Thr 20 25 30 Val Leu Ile Gly Ser Glu
His Gly Leu Ile Glu Val Asp Pro Val Ser 35
40 45 Arg Glu Val Lys Asn Glu Val Ser Leu Val Ala Glu Gly Phe Leu
Pro 50 55 60 Glu Asp Gly Ser Gly Arg Ile Val Gly Val Gln Asp Leu
Leu Asp Gln 65 70 75 80Glu Ser Val Cys Val Ala Thr Ala Ser Gly Asp
Val Ile Leu Cys Ser 85 90 95 Leu Ser Thr Gln Gln Leu Glu Cys Val
Gly Ser Val Ala Ser Gly Ile 100 105 110 Ser Val Met Ser Trp Ser Pro
Asp Gln Glu Leu Val Leu Leu Ala Thr 115 120 125 Gly Gln Gln Thr Leu
Ile Met Met Thr Lys Asp Phe Glu Pro Ile Leu 130 135 140 Glu Gln Gln
Ile His Gln Asp Asp Phe Gly Glu Ser Lys Phe Ile Thr 145 150 155
160Val Gly Trp Gly Arg Lys Glu Thr Gln Phe His Gly Ser Glu Gly Arg
165 170 175 Gln Ala Ala Phe Gln Met Gln Met His Glu Ser Ala Leu Pro
Trp Asp 180 185 190 Asp His Arg Pro Gln Val Thr Trp Arg Gly Asp Gly
Gln Phe Phe Ala 195 200 205 Val Ser Val Val Cys Pro Glu Thr Gly Ala
Arg Lys Val Arg Val Trp 210 215 220 Asn Arg Glu Phe Ala Leu Gln Ser
Thr Ser Glu Pro Val Ala Gly Leu 225 230 235 240Gly Pro Ala Leu Ala
Trp Lys Pro Ser Gly Ser Leu Ile Ala Ser Thr 245 250 255 Gln Asp Lys
Pro Asn Gln Gln Asp Ile Val Phe Phe Glu Lys Asn Gly 260 265 270 Leu
Leu His Gly His Phe Thr Leu Pro Phe Leu Lys Asp Glu Val Lys 275 280
285 Val Asn Asp Leu Leu Trp Asn Ala Asp Ser Ser Val Leu Ala Val Trp
290 295 300 Leu Glu Asp Leu Gln Arg Glu Glu Ser Ser Ile Pro Lys Thr
Cys Val 305 310 315 320Gln Leu Trp Thr Val Gly Asn Tyr His Trp Tyr
Leu Lys Gln Ser Leu 325 330 335 Ser Phe Ser Thr Cys Gly Lys Ser Lys
Ile Val Ser Leu Met Trp Asp 340 345 350 Pro Val Thr Pro Tyr Arg Leu
His Val Leu Cys Gln Gly Trp His Tyr 355 360 365 Leu Ala Tyr Asp Trp
His Trp Thr Thr Asp Arg Ser Val Gly Asp Asn 370 375 380 Ser Ser Asp
Leu Ser Asn Val Ala Val Ile Asp Gly Asn Arg Val Leu 385 390 395
400Val Thr Val Phe Arg Gln Thr Val Val Pro Pro Pro Met Cys Thr Tyr
405 410 415 Gln Leu Leu Phe Pro His Pro Val Asn Gln Val Thr Phe Leu
Ala His 420 425 430 Pro Gln Lys Ser Asn Asp Leu Ala Val Leu Asp Ala
Ser Asn Gln Ile 435 440 445 Ser Val Tyr Lys Cys Gly Asp Cys Pro Ser
Ala Asp Pro Thr Val Lys 450 455 460 Leu Gly Ala Val Gly Gly Ser Gly
Phe Lys Val Cys Leu Arg Thr Pro 465 470 475 480His Leu Glu Lys Arg
Tyr Lys Ile Gln Phe Glu Asn Asn Glu Asp Gln 485 490 495 Asp Val Asn
Pro Leu Lys Leu Gly Leu Leu Thr Trp Ile Glu Glu Asp 500 505 510 Val
Phe Leu Ala Val Ser His Ser Glu Phe Ser Pro Arg Ser Val Ile 515 520
525 His His Leu Thr Ala Ala Ser Ser Glu Met Asp Glu Glu His Gly Gln
530 535 540 Leu Asn Val Ser Ser Ser Ala Ala Val Asp Gly Val Ile Ile
Ser Leu 545 550 555 560Cys Cys Asn Ser Lys Thr Lys Ser Val Val Leu
Gln Leu Ala Asp Gly 565 570 575 Gln Ile Phe Lys Tyr Leu Trp Glu Ser
Pro Ser Leu Ala Ile Lys Pro 580 585 590 Trp Lys Asn Ser Gly Gly Phe
Pro Val Arg Phe Pro Tyr Pro Cys Thr 595 600 605 Gln Thr Glu Leu Ala
Met Ile Gly Glu Glu Glu Cys Val Leu Gly Leu 610 615 620 Thr Asp Arg
Cys Arg Phe Phe Ile Asn Asp Ile Glu Val Ala Ser Asn 625 630 635
640Ile Thr Ser Phe Ala Val Tyr Asp Glu Phe Leu Leu Leu Thr Thr His
645 650 655 Ser His Thr Cys Gln Cys Phe Cys Leu Arg Asp Ala Ser Phe
Lys Thr 660 665 670 Leu Gln Ala Gly Leu Ser Ser Asn His Val Ser His
Gly Glu Val Leu 675 680 685 Arg Lys Val Glu Arg Gly Ser Arg Ile Val
Thr Val Val Pro Gln Asp 690 695 700 Thr Lys Leu Val Leu Gln Met Pro
Arg Gly Asn Leu Glu Val Val His 705 710 715 720His Arg Ala Leu Val
Leu Ala Gln Ile Arg Lys Trp Leu Asp Lys Leu 725 730 735 Met Phe Lys
Glu Ala Phe Glu Cys Met Arg Lys Leu Arg Ile Asn Leu 740 745 750 Asn
Leu Ile Tyr Asp His Asn Pro Lys Val Phe Leu Gly Asn Val Glu 755 760
765 Thr Phe Ile Lys Gln Ile Asp Ser Val Asn His Ile Asn Leu Phe Phe
770 775 780 Thr Glu Leu Lys Glu Glu Asp Val Thr Lys Thr Met Tyr Pro
Ala Pro 785 790 795 800Val Thr Ser Ser Val Tyr Leu Ser Arg Asp Pro
Asp Gly Asn Lys Ile 805 810 815 Asp Leu Val Cys Asp Ala Met Arg Ala
Val Met Glu Ser Ile Asn Pro 820 825 830 His Lys Tyr Cys Leu Ser Ile
Leu Thr Ser His Val Lys Lys Thr Thr 835 840 845 Pro Glu Leu Glu Ile
Val Leu Gln Lys Val His Glu Leu Gln Gly Asn 850 855 860 Ala Pro Ser
Asp Pro Asp Ala Val Ser Ala Glu Glu Ala Leu Lys Tyr 865 870 875
880Leu Leu His Leu Val Asp Val Asn Glu Leu Tyr Asp His Ser Leu Gly
885 890 895 Thr Tyr Asp Phe Asp Leu Val Leu Met Val Ala Glu Lys Ser
Gln Lys 900 905 910 Asp Pro Lys Glu Tyr Leu Pro Phe Leu Asn Thr Leu
Lys Lys Met Glu 915 920 925 Thr Asn Tyr Gln Arg Phe Thr Ile Asp Lys
Tyr Leu Lys Arg Tyr Glu 930 935 940 Lys Ala Ile Gly His Leu Ser Lys
Cys Gly Pro Glu Tyr Phe Pro Glu 945 950 955 960Cys Leu Asn Leu Ile
Lys Asp Lys Asn Leu Tyr Asn Glu Ala Leu Lys 965 970 975 Leu Tyr Ser
Pro Ser Ser Gln Gln Tyr Gln Asp Ile Ser Ile Ala Tyr 980 985 990 Gly
Glu His Leu Met Gln Glu His Met Tyr Glu Pro Ala Gly Leu Met 995
1000 1005 Phe Ala Arg Cys Gly Ala His Glu Lys Ala Leu Ser Ala Phe
Leu Thr 1010 1015 1020 Cys Gly Asn Trp Lys Gln Ala Leu Cys Val Ala
Ala Gln Leu Asn Phe 1025 1030 1035 1040Thr Lys Asp Gln Leu Val Gly
Leu Gly Arg Thr Leu Ala Gly Lys Leu 1045 1050 1055 Val Glu Gln Arg
Lys His Ile Asp Ala Ala Met Val Leu Glu Glu Ser 1060 1065 1070 Ala
Gln Asp Tyr Glu Glu Ala Val Leu Leu Leu Leu Glu Gly Ala Ala 1075
1080 1085 Trp Glu Glu Ala Leu Arg Leu Val Tyr Lys Tyr Asn Arg Leu
Asp Ile 1090 1095 1100 Ile Glu Thr Asn Val Lys Pro Ser Ile Leu Glu
Ala Gln Lys Asn Tyr 1105 1110 1115 1120Met Ala Phe Leu Asp Ser Gln
Thr Ala Thr Phe Ser Arg His Lys Lys 1125 1130 1135 Arg Leu Leu Val
Val Arg Glu Leu Lys Glu Gln Ala Gln Gln Ala Gly 1140 1145 1150 Leu
Asp Asp Glu Val Pro His Gly Gln Glu Ser Asp Leu Phe Ser Glu 1155
1160 1165 Thr Ser Ser Val Val Ser Gly Ser Glu Met Ser Gly Lys Tyr
Ser His 1170 1175 1180 Ser Asn Ser Arg Ile Ser Ala Arg Ser Ser Lys
Asn Arg Arg Lys Ala 1185 1190 1195 1200Glu Arg Lys Lys His Ser Leu
Lys Glu Gly Ser Pro Leu Glu Asp Leu 1205 1210 1215 Ala Leu Leu Glu
Ala Leu Ser Glu Val Val Gln Asn Thr Glu Asn Leu 1220 1225 1230 Lys
Asp Glu Val Tyr His Ile Leu Lys Val Leu Phe Leu Phe Glu Phe 1235
1240 1245 Asp Glu Gln Gly Arg Glu Leu Gln Lys Ala Phe Glu Asp Thr
Leu Gln 1250 1255 1260 Leu Met Glu Arg Ser Leu Pro Glu Ile Trp Thr
Leu Thr Tyr Gln Gln 1265 1270 1275 1280Asn Ser Ala Thr Pro Val Leu
Gly Pro Asn Ser Thr Ala Asn Ser Ile 1285 1290 1295 Met Ala Ser Tyr
Gln Gln Gln Lys Thr Ser Val Pro Val Leu Asp Ala 1300 1305 1310 Glu
Leu Phe Ile Pro Pro Lys Ile Asn Arg Arg Thr Gln Trp Lys Leu 1315
1320 1325 Ser Leu Leu Asp 1330 61213PRTDrosophila melanogaster 6Met
Arg Asn Leu Lys Leu Arg Tyr Cys Lys Glu Leu Asn Ala Val Ala 1 5 10
15 His Pro Gln His Leu Leu Leu Gln Pro Glu Leu Asn Gly Gly Ala Ser
20 25 30 Asp Ile Tyr Phe Val Val Ala Asp Asn Lys Thr Tyr Ala Val
Gln Glu 35 40 45 Ser Gly Asp Val Arg Leu Lys Val Ile Ala Asp Leu
Pro Asp Ile Val 50 55 60 Gly Val Glu Phe Leu Gln Leu Asp Asn Ala
Ile Cys Val Ala Ser Gly 65 70 75 80Ala Gly Glu Val Ile Leu Val Asp
Pro Gln Thr Gly Ala Thr Ser Glu 85 90 95 Gly Thr Phe Cys Asp Val
Gly Ile Glu Ser Met Ala Trp Ser Pro Asn 100 105 110 Gln Glu Val Val
Ala Phe Val Thr Arg Thr His Asn Val Val Leu Met 115 120 125 Thr Ser
Thr Phe Asp Val Ile Ala Glu Gln Pro Leu Asp Ala Glu Leu 130 135 140
Asp Pro Asp Gln Gln Phe Val Asn Val Gly Trp Gly Lys Lys Glu Thr 145
150 155 160Gln Phe His Gly Ser Glu Gly Lys Gln Ala Ala Lys Gln Lys
Glu Ser 165 170 175 Asp Ser Thr Phe Thr Arg Asp Glu Gln Glu Leu Asn
Gln Asp Val Ser 180 185 190 Ile Ser Trp Arg Gly Asp Gly Glu Phe Phe
Val Val Ser Tyr Val Ala 195 200 205 Ala Gln Leu Gly Arg Thr Phe Lys
Val Tyr Asp Ser Glu Gly Lys Leu 210 215 220 Asn His Thr Ala Glu Lys
Ser Ala Asn Leu Lys Asp Ser Val Val Trp 225 230 235 240Arg Pro Thr
Gly Asn Trp Ile Ala Val Pro Gln Gln Phe Pro Asn Lys 245 250 255 Ser
Thr Ile Ala Leu Phe Glu Lys Asn Gly Leu Arg His Arg Glu Leu 260 265
270 Val Leu Pro Phe Asp Leu Gln Glu Glu Pro Val Val Gln Leu Arg Trp
275 280 285 Ser Glu Asp Ser Asp Ile Leu Ala Ile Arg Thr Cys Ala Lys
Glu Glu 290 295 300 Gln Arg Val Tyr Leu Tyr Thr Ile Gly Asn Tyr His
Trp Tyr Leu Lys 305 310 315 320Gln Val Leu Ile Phe Glu Gln Ala Asp
Pro Leu Ala Leu Leu His Trp 325 330 335 Asp Thr Arg Cys Gly Ala Glu
His Thr Leu His Val Leu Lys Glu Ser 340 345 350 Gly Lys His Leu Val
Tyr Arg Trp Ala Phe Ala Val Asp Arg Asn Asn 355 360 365 Ser Ile Val
Gly Val Ile Asp Gly Lys Arg Leu Leu Leu Thr Asp Phe 370 375 380 Asp
Glu Ala Ile Val Pro Pro Pro Met Ser Lys Glu Leu Gln Lys Pro 385 390
395 400Ile Met Leu Met Pro Asp Ala Glu Leu Ser Gly Leu His Leu Ala
Asn 405 410 415 Leu Thr His Phe Ser Pro His Tyr Leu Leu Ala Thr His
Ser Ser Ala 420 425 430 Gly Ser Thr Arg Leu Leu Leu Leu Ser Tyr Lys
Asp Asn Asp Asn Lys 435 440 445 Pro Gly Glu Trp Phe Tyr Arg Val His
Ser Ser Val Arg Ile Asn Gly 450 455 460 Leu Val Asn Ala Val Ala Val
Ala Pro Tyr Ala Met Asn Glu Phe Tyr 465 470 475 480Val Gln Thr Val
Asn Asn Gly His Thr Tyr Glu Val Ser Leu Lys Ala 485 490 495 Asp Lys
Thr Leu Lys Val Glu Arg Ser Tyr Val Gln Leu His Glu Pro 500 505 510
Ala Asp Gln Ile Asp Trp Val Ile Val Lys Gly Cys Ile Trp Asp Gly 515
520 525 Tyr Thr Gly Ala Leu Val Thr Leu Arg Asn Gln His Leu Leu His
Ile 530 535 540 Asp Gly Tyr Arg Ile Gly Glu Asp Val Thr Ser Phe Cys
Val Val Thr 545 550 555 560Asn Tyr Leu Val Tyr Thr Gln Leu Asn Ala
Met His Phe Val Gln Leu 565 570 575 Asp Asp Arg Arg Gln Val Ala Ser
Arg Asn Ile Glu Arg Gly Ala Lys 580 585 590 Ile Val Thr Ala Val Ala
Arg Lys Ala Arg Val Val Leu Gln Leu Pro 595 600 605 Arg Gly Asn Leu
Glu Ala Ile Cys Pro Arg Val Leu Val Leu Glu Leu 610 615 620 Val Gly
Asp Leu Leu Glu Arg Gly Lys Tyr Gln Lys Ala Ile Glu Met 625 630 635
640Ser Arg Lys Gln Arg Ile Asn Leu Asn Ile Ile Phe Asp His Asp Val
645 650 655 Lys Arg Phe Val Ser Ser Val Gly Ala Phe Leu Asn Asp Ile
Asn Glu 660 665 670 Pro Gln Trp Leu Cys Leu Phe Leu Ser Glu Leu Gln
Asn Glu Asp Phe 675 680 685 Thr Lys Gly Met Tyr Ser Ser Asn Tyr Asp
Ala Ser Lys Gln Thr Tyr 690 695 700 Pro Ser Asp Tyr Arg Val Asp Gln
Lys Val Phe Tyr Val Cys Arg Leu 705 710 715 720Leu Glu Gln Gln Met
Asn Arg Phe Val Ser Arg Phe Arg Leu Pro Leu 725 730 735 Ile Thr Ala
Tyr Val Lys Leu Gly Cys Leu Glu Met Ala Leu Gln Val 740 745 750 Ile
Trp Lys Glu Gln Gln Glu Asp Ala Ser Leu Ala Asp Gln Leu Leu 755 760
765 Gln His Leu Leu Tyr Leu Val Asp Val Asn Asp Leu Tyr Asn Val Ala
770 775 780 Leu Gly Thr Tyr Asp Phe Gly Leu Val Leu Phe Val Ala Gln
Lys Ser 785 790 795 800Gln Lys Asp Pro Lys Glu Phe Leu Pro Tyr Leu
Asn Asp Leu Lys Ala 805 810 815 Leu Pro Ile Asp Tyr Arg Lys Phe Arg
Ile Asp Asp His Leu Lys Arg 820 825 830 Tyr Thr Ser Ala Leu Ser His
Leu Ala Ala Cys Gly Glu Gln His Tyr 835 840 845 Glu Glu Ala Leu Glu
Tyr Ile Arg Lys His Gly Leu Tyr Thr Asp Gly 850 855 860 Leu Ala Phe
Tyr Arg Glu His Ile Glu Phe Gln Lys Asn Ile Tyr Val 865 870 875
880Ala Tyr Ala Asp His Leu Arg Ala Ile Ala Lys Leu Asp Asn Ala Ser
885 890 895 Leu Met Tyr Glu Arg Gly Gly Gln Leu Gln Gln Ala Leu Leu
Ser Ala 900 905 910 Lys His Thr Leu Asp Trp Gln Arg Val Leu Val Leu
Ala Lys Lys Leu 915 920 925 Ser Glu Pro Leu Asp Gln Val Ala Gln Ser
Leu Val Gly Pro Leu Gln 930 935 940 Gln Gln Gly Arg His Met Glu Ala
Tyr Glu Leu Val Lys Glu His Cys 945 950 955 960Gln Asp Arg Lys Arg
Gln Phe Asp Val Leu Leu Glu Gly His Leu Tyr 965 970 975 Ser Arg Ala
Ile Tyr Glu Ala Gly Leu Glu Asp Asp Asp Val Ser Glu 980 985 990 Lys
Ile Ala Pro Ala Leu Leu Ala Tyr Gly Val Gln Leu Glu
Ser Ser 995 1000 1005 Leu Gln Ala Asp Leu Gln Leu Phe Leu Asp Tyr
Lys Gln Arg Leu Leu 1010 1015 1020 Asp Ile Arg Arg Asn Gln Ala Lys
Ser Gly Glu Gly Tyr Ile Asp Thr 1025 1030 1035 1040Asp Val Asn Leu
Lys Glu Val Asp Leu Leu Ser Asp Thr Thr Ser Leu 1045 1050 1055 His
Ser Ser Gln Tyr Ser Gly Thr Ser Arg Arg Thr Gly Lys Thr Phe 1060
1065 1070 Arg Ser Ser Lys Asn Arg Arg Lys His Glu Arg Lys Leu Phe
Ser Leu 1075 1080 1085 Lys Pro Gly Asn Pro Phe Glu Asp Ile Ala Leu
Ile Asp Ala Leu His 1090 1095 1100 Asn His Val Thr Lys Ile Ala Gln
Gln Gln Gln Pro Val Arg Asp Thr 1105 1110 1115 1120Cys Lys Ala Leu
Leu Gln Leu Ala Asn Ala Ala Asp Ala Asp Pro Leu 1125 1130 1135 Ala
Ala Ala Leu Gln Arg Glu Phe Lys Thr Leu Leu Gln Ala Val Asp 1140
1145 1150 Ala Ala Leu Asp Glu Ile Trp Thr Pro Glu Leu Arg Gly Asn
Gly Leu 1155 1160 1165 Met Ala Asp His Leu Thr Gly Pro Asn Val Asp
Tyr Leu Ala Leu Gln 1170 1175 1180 Lys Glu Gln Arg Tyr Ala Leu Leu
Ser Pro Leu Lys Arg Phe Lys Pro 1185 1190 1195 1200Gln Leu Ile Met
Met Asp Trp Gln His Glu Ile Leu Gln 1205 1210 71349PRTSaccharomyces
cerevisiae 7Met Val Glu His Asp Lys Ser Gly Ser Lys Arg Gln Glu Leu
Arg Ser 1 5 10 15 Asn Met Arg Asn Leu Ile Thr Leu Asn Lys Gly Lys
Phe Lys Pro Thr 20 25 30 Ala Ser Thr Ala Glu Gly Asp Glu Asp Asp
Leu Ser Phe Thr Leu Leu 35 40 45 Asp Ser Val Phe Asp Thr Leu Ser
Asp Ser Ile Thr Cys Val Leu Gly 50 55 60 Ser Thr Asp Ile Gly Ala
Ile Glu Val Gln Gln Phe Met Lys Asp Gly 65 70 75 80Ser Arg Asn Val
Leu Ala Ser Phe Asn Ile Gln Thr Phe Asp Asp Lys 85 90 95 Leu Leu
Ser Phe Val His Phe Ala Asp Ile Asn Gln Leu Val Phe Val 100 105 110
Phe Glu Gln Gly Asp Ile Ile Thr Ala Thr Tyr Asp Pro Val Ser Leu 115
120 125 Asp Pro Ala Glu Thr Leu Ile Glu Ile Met Gly Thr Ile Asp Asn
Gly 130 135 140 Ile Ala Ala Ala Gln Trp Ser Tyr Asp Glu Glu Thr Leu
Ala Met Val 145 150 155 160Thr Lys Asp Arg Asn Val Val Val Leu Ser
Lys Leu Phe Glu Pro Ile 165 170 175 Ser Glu Tyr His Leu Glu Val Asp
Asp Leu Lys Ile Ser Lys His Val 180 185 190 Thr Val Gly Trp Gly Lys
Lys Glu Thr Gln Phe Arg Gly Lys Gly Ala 195 200 205 Arg Ala Met Glu
Arg Glu Ala Leu Ala Ser Leu Lys Ala Ser Gly Leu 210 215 220 Val Gly
Asn Gln Leu Arg Asp Pro Thr Met Pro Tyr Met Val Asp Thr 225 230 235
240Gly Asp Val Thr Ala Leu Asp Ser His Glu Ile Thr Ile Ser Trp Arg
245 250 255 Gly Asp Cys Asp Tyr Phe Ala Val Ser Ser Val Glu Glu Val
Pro Asp 260 265 270 Glu Asp Asp Glu Thr Lys Ser Ile Lys Arg Arg Ala
Phe Arg Val Phe 275 280 285 Ser Arg Glu Gly Gln Leu Asp Ser Ala Ser
Glu Pro Val Thr Gly Met 290 295 300 Glu His Gln Leu Ser Trp Lys Pro
Gln Gly Ser Leu Ile Ala Ser Ile 305 310 315 320Gln Arg Lys Thr Asp
Leu Gly Glu Glu Asp Ser Val Asp Val Ile Phe 325 330 335 Phe Glu Arg
Asn Gly Leu Arg His Gly Glu Phe Asp Thr Arg Leu Pro 340 345 350 Leu
Asp Glu Lys Val Glu Ser Val Cys Trp Asn Ser Asn Ser Glu Ala 355 360
365 Leu Ala Val Val Leu Ala Asn Arg Ile Gln Leu Trp Thr Ser Lys Asn
370 375 380 Tyr His Trp Tyr Leu Lys Gln Glu Leu Tyr Ala Ser Asp Ile
Ser Tyr 385 390 395 400Val Lys Trp His Pro Glu Lys Asp Phe Thr Leu
Met Phe Ser Asp Ala 405 410 415 Gly Phe Ile Asn Ile Val Asp Phe Ala
Tyr Lys Met Ala Gln Gly Pro 420 425 430 Thr Leu Glu Pro Phe Asp Asn
Gly Thr Ser Leu Val Val Asp Gly Arg 435 440 445 Thr Val Asn Ile Thr
Pro Leu Ala Leu Ala Asn Val Pro Pro Pro Met 450 455 460 Tyr Tyr Arg
Asp Phe Glu Thr Pro Gly Asn Val Leu Asp Val Ala Cys 465 470 475
480Ser Phe Ser Asn Glu Ile Tyr Ala Ala Ile Asn Lys Asp Val Leu Ile
485 490 495 Phe Ala Ala Val Pro Ser Ile Glu Glu Met Lys Lys Gly Lys
His Pro 500 505 510 Ser Ile Val Cys Glu Phe Pro Lys Ser Glu Phe Thr
Ser Glu Val Asp 515 520 525 Ser Leu Arg Gln Val Ala Phe Ile Asn Asp
Ser Ile Val Gly Val Leu 530 535 540 Leu Asp Thr Asp Asn Leu Ser Arg
Ile Ala Leu Leu Asp Ile Gln Asp 545 550 555 560Ile Thr Gln Pro Thr
Leu Ile Thr Ile Val Glu Val Tyr Asp Lys Ile 565 570 575 Val Leu Leu
Ser Ser Asp Phe Asp Tyr Asn His Leu Val Tyr Glu Thr 580 585 590 Arg
Asp Gly Thr Val Cys Gln Leu Asp Ala Glu Gly Gln Leu Met Glu 595 600
605 Ile Thr Lys Phe Pro Gln Leu Val Arg Asp Phe Arg Val Lys Arg Val
610 615 620 His Asn Thr Ser Ala Glu Asp Asp Asp Asn Trp Ser Ala Glu
Ser Ser 625 630 635 640Glu Leu Val Ala Phe Gly Ile Thr Asn Asn Gly
Lys Leu Phe Ala Asn 645 650 655 Gln Val Leu Leu Ala Ser Ala Val Thr
Ser Leu Glu Ile Thr Asp Ser 660 665 670 Phe Leu Leu Phe Thr Thr Ala
Gln His Asn Leu Gln Phe Val His Leu 675 680 685 Asn Ser Thr Asp Phe
Lys Pro Leu Pro Leu Val Glu Glu Gly Val Glu 690 695 700 Asp Glu Arg
Val Arg Ala Ile Glu Arg Gly Ser Ile Leu Val Ser Val 705 710 715
720Ile Pro Ser Lys Arg Ser Val Val Leu Gln Ala Thr Arg Gly Asn Leu
725 730 735 Glu Thr Ile Tyr Pro Arg Ile Met Val Leu Ala Glu Val Arg
Lys Asn 740 745 750 Ile Met Ala Lys Arg Tyr Lys Glu Ala Phe Ile Val
Cys Arg Thr His 755 760 765 Arg Ile Asn Leu Asp Ile Leu His Asp Tyr
Ala Pro Glu Leu Phe Ile 770 775 780 Glu Asn Leu Glu Val Phe Ile Asn
Gln Ile Gly Arg Val Asp Tyr Leu 785 790 795 800Asn Leu Phe Ile Ser
Cys Leu Ser Glu Asp Asp Val Thr Lys Thr Lys 805 810 815 Tyr Lys Glu
Thr Leu Tyr Ser Gly Ile Ser Lys Ser Phe Gly Met Glu 820 825 830 Pro
Ala Pro Leu Thr Glu Met Gln Ile Tyr Met Lys Lys Lys Met Phe 835 840
845 Asp Pro Lys Thr Ser Lys Val Asn Lys Ile Cys Asp Ala Val Leu Asn
850 855 860 Val Leu Leu Ser Asn Pro Glu Tyr Lys Lys Lys Tyr Leu Gln
Thr Ile 865 870 875 880Ile Thr Ala Tyr Ala Ser Gln Asn Pro Gln Asn
Leu Ser Ala Ala Leu 885 890 895 Lys Leu Ile Ser Glu Leu Glu Asn Ser
Glu Glu Lys Asp Ser Cys Val 900 905 910 Thr Tyr Leu Cys Phe Leu Gln
Asp Val Asn Val Val Tyr Lys Ser Ala 915 920 925 Leu Ser Leu Tyr Asp
Val Ser Leu Ala Leu Leu Val Ala Gln Lys Ser 930 935 940 Gln Met Asp
Pro Arg Glu Tyr Leu Pro Phe Leu Gln Glu Leu Gln Asp 945 950 955
960Asn Glu Pro Leu Arg Arg Lys Phe Leu Ile Asp Asp Tyr Leu Gly Asn
965 970 975 Tyr Glu Lys Ala Leu Glu His Leu Ser Glu Ile Asp Lys Asp
Gly Asn 980 985 990 Val Ser Glu Glu Val Ile Asp Tyr Val Glu Ser His
Asp Leu Tyr Lys 995 1000 1005 His Gly Leu Ala Leu Tyr Arg Tyr Asp
Ser Glu Lys Gln Asn Val Ile 1010 1015 1020 Tyr Asn Ile Tyr Ala Lys
His Leu Ser Ser Asn Gln Met Tyr Thr Asp 1025 1030 1035 1040Ala Ala
Val Ala Tyr Glu Met Leu Gly Lys Leu Lys Glu Ala Met Gly 1045 1050
1055 Ala Tyr Gln Ser Ala Lys Arg Trp Arg Glu Ala Met Ser Ile Ala
Val 1060 1065 1070 Gln Lys Phe Pro Glu Glu Val Glu Ser Val Ala Glu
Glu Leu Ile Ser 1075 1080 1085 Ser Leu Thr Phe Glu His Arg Tyr Val
Asp Ala Ala Asp Ile Gln Leu 1090 1095 1100 Glu Tyr Leu Asp Asn Val
Lys Glu Ala Val Ala Leu Tyr Cys Lys Ala 1105 1110 1115 1120Tyr Arg
Tyr Asp Ile Ala Ser Leu Val Ala Ile Lys Ala Lys Lys Asp 1125 1130
1135 Glu Leu Leu Glu Glu Val Val Asp Pro Gly Leu Gly Glu Gly Phe
Gly 1140 1145 1150 Ile Ile Ala Glu Leu Leu Ala Asp Cys Lys Gly Gln
Ile Asn Ser Gln 1155 1160 1165 Leu Arg Arg Leu Arg Glu Leu Arg Ala
Lys Lys Glu Glu Asn Pro Tyr 1170 1175 1180 Ala Phe Tyr Gly Gln Glu
Thr Glu Gln Ala Asp Asp Val Ser Val Ala 1185 1190 1195 1200Pro Ser
Glu Thr Ser Thr Gln Glu Ser Phe Phe Thr Arg Tyr Thr Gly 1205 1210
1215 Lys Thr Gly Gly Thr Ala Lys Thr Gly Ala Ser Arg Arg Thr Ala
Lys 1220 1225 1230 Asn Lys Arg Arg Glu Glu Arg Lys Arg Ala Arg Gly
Lys Lys Gly Thr 1235 1240 1245 Ile Tyr Glu Glu Glu Tyr Leu Val Gln
Ser Val Gly Arg Leu Ile Glu 1250 1255 1260 Arg Leu Asn Gln Thr Lys
Pro Asp Ala Val Arg Val Val Glu Gly Leu 1265 1270 1275 1280Cys Arg
Arg Asn Met Arg Glu Gln Ala His Gln Ile Gln Lys Asn Phe 1285 1290
1295 Val Glu Val Leu Asp Leu Leu Lys Ala Asn Val Lys Glu Ile Tyr
Ser 1300 1305 1310 Ile Ser Glu Lys Asp Arg Glu Arg Val Asn Glu Asn
Gly Glu Val Tyr 1315 1320 1325 Tyr Ile Pro Glu Ile Pro Val Pro Glu
Ile His Asp Phe Pro Lys Ser 1330 1335 1340 His Ile Val Asp Phe 1345
81319PRTArabidopsis thaliana 8Met Lys Asn Leu Lys Leu Phe Ser Glu
Val Pro Gln Asn Ile Gln Leu 1 5 10 15 His Ser Thr Glu Glu Val Val
Gln Phe Ala Ala Thr Asp Ile Asp Gln 20 25 30 Ser Arg Leu Phe Phe
Ala Ser Ser Ala Asn Phe Val Tyr Ala Leu Gln 35 40 45 Leu Ser Ser
Phe Gln Asn Glu Ser Ala Gly Ala Lys Ser Ala Met Pro 50 55 60 Val
Glu Val Cys Ser Ile Asp Ile Glu Pro Gly Asp Phe Ile Thr Ala 65 70
75 80Phe Asp Tyr Leu Ala Glu Lys Glu Ser Leu Leu Ile Gly Thr Ser
His 85 90 95 Gly Leu Leu Leu Val His Asn Val Glu Ser Asp Val Thr
Glu Leu Val 100 105 110 Gly Asn Ile Glu Gly Gly Val Lys Cys Ile Ser
Pro Asn Pro Thr Gly 115 120 125 Asp Leu Leu Gly Leu Ile Thr Gly Leu
Gly Gln Leu Ile Val Met Thr 130 135 140 Tyr Asp Trp Ala Leu Met Tyr
Glu Lys Ala Leu Gly Glu Val Pro Glu 145 150 155 160Gly Gly Tyr Val
Arg Glu Thr Asn Asp Leu Ser Val Asn Cys Gly Gly 165 170 175 Ile Ser
Ile Ser Trp Arg Gly Asp Gly Lys Tyr Phe Ala Thr Met Gly 180 185 190
Glu Val Tyr Glu Ser Gly Cys Met Ser Lys Lys Ile Lys Ile Trp Glu 195
200 205 Ser Asp Ser Gly Ala Leu Gln Ser Ser Ser Glu Thr Lys Glu Phe
Thr 210 215 220 Gln Gly Ile Leu Glu Trp Met Pro Ser Gly Ala Lys Ile
Ala Ala Val 225 230 235 240Tyr Lys Arg Lys Ser Asp Asp Ser Ser Pro
Ser Ile Ala Phe Phe Glu 245 250 255 Arg Asn Gly Leu Glu Arg Ser Ser
Phe Arg Ile Gly Glu Pro Glu Asp 260 265 270 Ala Thr Glu Ser Cys Glu
Asn Leu Lys Trp Asn Ser Ala Ser Asp Leu 275 280 285 Leu Ala Gly Val
Val Ser Cys Lys Thr Tyr Asp Ala Ile Arg Val Trp 290 295 300 Phe Phe
Ser Asn Asn His Trp Tyr Leu Lys Gln Glu Ile Arg Tyr Pro 305 310 315
320Arg Glu Ala Gly Val Thr Val Met Trp Asp Pro Thr Lys Pro Leu Gln
325 330 335 Leu Ile Cys Trp Thr Leu Ser Gly Gln Val Ser Val Arg His
Phe Met 340 345 350 Trp Val Thr Ala Val Met Glu Asp Ser Thr Ala Phe
Val Ile Asp Asn 355 360 365 Ser Lys Ile Leu Val Thr Pro Leu Ser Leu
Ser Leu Met Pro Pro Pro 370 375 380 Met Tyr Leu Phe Ser Leu Ser Phe
Ser Ser Ala Val Arg Asp Ile Ala 385 390 395 400Tyr Tyr Ser Arg Asn
Ser Lys Asn Cys Leu Ala Val Phe Leu Ser Asp 405 410 415 Gly Asn Leu
Ser Phe Val Glu Phe Pro Ala Pro Asn Thr Trp Glu Asp 420 425 430 Leu
Glu Gly Lys Asp Phe Ser Val Glu Ile Ser Asp Cys Lys Thr Ala 435 440
445 Leu Gly Ser Phe Val His Leu Leu Trp Leu Asp Val His Ser Leu Leu
450 455 460 Cys Val Ser Ala Tyr Gly Ser Ser His Asn Lys Cys Leu Ser
Ser Gly 465 470 475 480Gly Tyr Asp Thr Glu Leu His Gly Ser Tyr Leu
Gln Glu Val Glu Val 485 490 495 Val Cys His Glu Asp His Val Pro Asp
Gln Val Thr Cys Ser Gly Phe 500 505 510 Lys Ala Ser Ile Thr Phe Gln
Thr Leu Leu Glu Ser Pro Val Leu Ala 515 520 525 Leu Ala Trp Asn Pro
Ser Lys Arg Asp Ser Ala Phe Val Glu Phe Glu 530 535 540 Gly Gly Lys
Val Leu Gly Tyr Ala Ser Arg Ser Glu Ile Met Glu Thr 545 550 555
560Arg Ser Ser Asp Asp Ser Val Cys Phe Pro Ser Thr Cys Pro Trp Val
565 570 575 Arg Val Ala Gln Val Asp Ala Ser Gly Val His Lys Pro Leu
Ile Cys 580 585 590 Gly Leu Asp Asp Met Gly Arg Leu Ser Ile Asn Gly
Lys Asn Leu Cys 595 600 605 Asn Asn Cys Ser Ser Phe Ser Phe Tyr Ser
Glu Leu Ala Asn Glu Val 610 615 620 Val Thr His Leu Ile Ile Leu Thr
Lys Gln Asp Phe Leu Phe Ile Val 625 630 635 640Asp Thr Lys Asp Val
Leu Asn Gly Asp Val Ala Leu Gly Asn Val Phe 645 650 655 Phe Val Ile
Asp Gly Arg Arg Arg Asp Glu Glu Asn Met Ser Tyr Val 660 665 670 Asn
Ile Trp Glu Arg Gly Ala Lys Val Ile Gly Val Leu Asn Gly Asp 675 680
685 Glu Ala Ala Val Ile Leu Gln Thr Met Arg Gly Asn Leu Glu Cys Ile
690 695 700 Tyr Pro Arg Lys Leu Val Leu Ser Ser Ile Thr Asn Ala Leu
Ala Gln 705 710
715 720Gln Arg Phe Lys Asp Ala Phe Asn Leu Val Arg Arg His Arg Ile
Asp 725 730 735 Phe Asn Val Ile Val Asp Leu Tyr Gly Trp Gln Ala Phe
Leu Gln Ser 740 745 750 Ala Val Ala Phe Val Glu Gln Val Asn Asn Leu
Asn His Val Thr Glu 755 760 765 Phe Val Cys Ala Met Lys Asn Glu Asp
Val Thr Glu Thr Leu Tyr Lys 770 775 780 Lys Phe Ser Phe Ser Lys Lys
Gly Asp Glu Val Phe Arg Val Lys Asp 785 790 795 800Ser Cys Ser Asn
Lys Val Ser Ser Val Leu Gln Ala Ile Arg Lys Ala 805 810 815 Leu Glu
Glu His Ile Pro Glu Ser Pro Ser Arg Glu Leu Cys Ile Leu 820 825 830
Thr Thr Leu Ala Arg Ser Asp Pro Pro Ala Ile Glu Glu Ser Leu Leu 835
840 845 Arg Ile Lys Ser Val Arg Glu Met Glu Leu Leu Asn Ser Ser Asp
Asp 850 855 860 Ile Arg Lys Lys Ser Cys Pro Ser Ala Glu Glu Ala Leu
Lys His Leu 865 870 875 880Leu Trp Leu Leu Asp Ser Glu Ala Val Phe
Glu Ala Ala Leu Gly Leu 885 890 895 Tyr Asp Leu Asn Leu Ala Ala Ile
Val Ala Leu Asn Ser Gln Arg Asp 900 905 910 Pro Lys Glu Phe Leu Pro
Tyr Leu Gln Glu Leu Glu Lys Met Pro Glu 915 920 925 Ser Leu Met His
Phe Lys Ile Asp Ile Lys Leu Gln Arg Phe Asp Ser 930 935 940 Ala Leu
Arg Asn Ile Val Ser Ala Gly Val Gly Tyr Phe Pro Asp Cys 945 950 955
960Met Asn Leu Ile Lys Lys Asn Pro Gln Leu Phe Pro Leu Gly Leu Leu
965 970 975 Leu Ile Thr Asp Pro Glu Lys Lys Leu Val Val Leu Glu Ala
Trp Ala 980 985 990 Asp His Leu Ile Asp Glu Lys Arg Phe Glu Asp Ala
Ala Thr Thr Tyr 995 1000 1005 Leu Cys Cys Cys Lys Leu Glu Lys Ala
Ser Lys Ala Tyr Arg Glu Cys 1010 1015 1020 Gly Asp Trp Ser Gly Val
Leu Arg Val Gly Ala Leu Met Lys Leu Gly 1025 1030 1035 1040Lys Asp
Glu Ile Leu Lys Leu Ala Tyr Glu Leu Cys Glu Glu Val Asn 1045 1050
1055 Ala Leu Gly Lys Pro Ala Glu Ala Ala Lys Ile Ala Leu Glu Tyr
Cys 1060 1065 1070 Ser Asp Ile Ser Gly Gly Ile Ser Leu Leu Ile Asn
Ala Arg Glu Trp 1075 1080 1085 Glu Glu Ala Leu Arg Val Ala Phe Leu
His Thr Ala Asp Asp Arg Ile 1090 1095 1100 Ser Val Val Lys Ser Ser
Ala Leu Glu Cys Ala Ser Gly Leu Val Ser 1105 1110 1115 1120Glu Phe
Lys Glu Ser Ile Glu Lys Val Gly Lys Tyr Leu Thr Arg Tyr 1125 1130
1135 Leu Ala Val Arg Gln Arg Arg Leu Leu Leu Ala Ala Lys Leu Lys
Ser 1140 1145 1150 Glu Glu Arg Ser Val Val Asp Leu Asp Asp Asp Thr
Ala Ser Glu Ala 1155 1160 1165 Ser Ser Asn Leu Ser Gly Met Ser Ala
Tyr Thr Leu Gly Thr Arg Arg 1170 1175 1180 Gly Ser Ala Ala Ser Val
Ser Ser Ser Asn Ala Thr Ser Arg Ala Arg 1185 1190 1195 1200Asp Leu
Arg Arg Gln Arg Lys Ser Gly Lys Ile Arg Ala Gly Ser Ala 1205 1210
1215 Gly Glu Glu Met Ala Leu Val Asp His Leu Lys Gly Met Arg Met
Thr 1220 1225 1230 Asp Gly Gly Lys Arg Glu Leu Lys Ser Leu Leu Ile
Cys Leu Val Thr 1235 1240 1245 Leu Gly Glu Met Glu Ser Ala Gln Lys
Leu Gln Gln Thr Ala Glu Asn 1250 1255 1260 Phe Gln Val Ser Gln Val
Ala Ala Val Glu Leu Ala His Asp Thr Val 1265 1270 1275 1280Ser Ser
Glu Ser Val Asp Glu Glu Val Tyr Cys Phe Glu Arg Tyr Ala 1285 1290
1295 Gln Lys Thr Arg Ser Thr Ala Arg Asp Ser Asp Ala Phe Ser Trp
Met 1300 1305 1310 Leu Lys Val Phe Ile Ser Pro 1315
91178PRTCaenorhabditis elegans 9Met Lys Asn Leu Gln Ile Gly Ser Val
Lys Thr Phe Glu Asn Pro Glu 1 5 10 15 Ile Ala Gly Ala Asp Asp Phe
Ala Val His Pro Ile Leu Gln Thr Ile 20 25 30 Ala Val Ser Thr Lys
Asn Glu Leu Leu Leu Leu Glu Asn Asn Leu Ile 35 40 45 Ser Ser Thr
Ile Lys Trp Ala Glu Gln Arg Arg Glu Leu Glu Val Ile 50 55 60 Ser
Leu Ser Phe Arg Thr Asp Gly Asn Gln Ile Val Val Ile Leu Ala 65 70
75 80Asp Gly Arg Ala Leu Ile Val Glu Asp Gly Glu Val Met Asp Leu
Glu 85 90 95 Ile Ala Glu Leu Thr Asp Thr Thr Val Ser Ala Ala Glu
Trp Thr Ala 100 105 110 Asp Glu Gln Thr Leu Ala Leu Ala Asp Asn Gln
Thr Leu Tyr Leu Ala 115 120 125 Asp Ser Ser Leu Val Pro Phe Ala Glu
Arg Pro Leu Ile Phe Ser Glu 130 135 140 Asn Glu Arg Lys Ser Ala Pro
Val Asn Val Gly Trp Gly Ser Glu Ser 145 150 155 160Thr Gln Phe Arg
Gly Ser Ala Gly Lys Leu Lys Pro Gly Glu Lys Ile 165 170 175 Glu Lys
Glu Lys Glu Gln Ile Glu Gln His Ser Arg Lys Thr Ser Val 180 185 190
His Trp Arg Trp Asp Gly Glu Ile Val Ala Val Ser Phe Tyr Ser Ser 195
200 205 Gln Asn Asp Thr Arg Asn Leu Thr Val Phe Asp Arg Asn Gly Glu
Ile 210 215 220 Leu Asn Asn Met Asn Ile Arg Asn Ile Tyr Leu Ser His
Cys Phe Ala 225 230 235 240His Lys Pro Asn Ala Asn Leu Leu Cys Ser
Ala Ile Gln Glu Asn Gly 245 250 255 Ser Asp Asp Arg Ile Val Ile Tyr
Glu Arg Asn Gly Glu Thr Arg Asn 260 265 270 Ser Tyr Val Val Lys Trp
Pro Ala Asn Gln Ile Glu Asp Arg Arg Ile 275 280 285 Ile Glu Lys Ile
Glu Trp Asn Ser Thr Gly Thr Ile Leu Ser Met Gln 290 295 300 Thr Ser
Leu Gly Lys Lys His Gln Leu Glu Phe Trp His Leu Ser Asn 305 310 315
320Tyr Glu Phe Thr Arg Lys Cys Tyr Trp Lys Phe Ser Glu Ser Ile Ile
325 330 335 Trp Lys Trp Ser Thr Val Glu Cys Gln Asn Ile Glu Val Leu
Leu Glu 340 345 350 Ser Gly Gln Phe Phe Ser Val His Ile Thr Pro Thr
Ala Ser Phe Ser 355 360 365 Asp Val Ile Ser Gln Asn Val Val Val Ala
Thr Asp Glu Leu Arg Met 370 375 380 Tyr Ser Leu Cys Arg Arg Val Val
Pro Pro Pro Met Cys Asp Tyr Ser 385 390 395 400Ile Gln Cys Leu Ser
Asp Ile Val Ala Tyr Thr Thr Ser Thr His His 405 410 415 Val His Val
Ile Thr Ser Asp Trp Lys Ile Ile Ser Cys Met Leu Phe 420 425 430 Phe
Lys Lys Lys Lys Arg Asn Tyr Ser Asn Pro Phe Phe Arg Lys Lys 435 440
445 Tyr Ile Leu Glu Ile Leu Lys Val Pro Ser His Lys Thr Tyr Phe Ala
450 455 460 Cys Phe Ala Val Ser Gln Asp Thr Asp Gly Tyr Lys Phe Asn
Ser Asp 465 470 475 480Arg Ala Ser Ile Asp Glu Val Leu His Thr Glu
Val Thr Glu Gly Ile 485 490 495 Ile Cys Gly Phe Val Tyr Asp Glu Pro
Ser Glu Ser Tyr Ile Ile Trp 500 505 510 Asn Val Ser His Gly Lys His
Gln Ile Ser Arg Val Gly Ala Asn Pro 515 520 525 Glu Lys Ile Phe Glu
Gly Glu Asn Ile Gly Trp Ile Gly Val Asn Pro 530 535 540 Ser Asn Lys
His Val Glu Ile Ala Ser Asn Asp Gly Lys Phe Ile Asp 545 550 555
560Leu Asn Thr Lys Glu Glu Leu Phe Lys Ile Asp Lys Phe Glu Ser Thr
565 570 575 Glu Val His Phe Ile Gln Val Cys His Gly Ile Leu Asn His
His Val 580 585 590 Ile Gln Val Asp Asn Ser Met Leu Phe Leu Asp Ser
Glu Arg Val Ser 595 600 605 Gln Asp Ala Ile Ser Ile Leu Thr Arg Gly
Ser Asp Ile Leu Leu Ile 610 615 620 Asp Phe Asp Asn Lys Leu Arg Phe
Ile Asp Ala Glu Ser Gly Lys Thr 625 630 635 640Leu Glu Asp Val Arg
Asn Val Glu Ala Gly Cys Glu Leu Val Ala Cys 645 650 655 Asp Ser Gln
Ser Ala Asn Val Ile Leu Gln Ala Ala Arg Gly Asn Leu 660 665 670 Glu
Thr Ile Gln Pro Arg Arg Tyr Val Met Ala His Thr Arg Asp Leu 675 680
685 Leu Asp Arg Lys Glu Tyr Ile Ala Ser Phe Lys Trp Met Lys Lys His
690 695 700 Arg Val Asp Met Ser Phe Ala Met Lys Tyr Lys Gly Asp Asp
Leu Glu 705 710 715 720Asp Asp Ile Pro Ile Trp Leu Lys Thr Ser Asn
Asp Ser Gln Phe Leu 725 730 735 Glu Gln Leu Leu Ile Ser Cys Thr Glu
Val Phe Glu Asp Ala Gly Ser 740 745 750 Ser Leu Cys Met Thr Val Ala
Arg Tyr Val Arg Asp Leu Ser Asp Ala 755 760 765 Glu Lys Thr Lys Met
Phe Pro Leu Leu Leu Thr Ala Leu Leu Ser Ala 770 775 780 Arg Ser Lys
Pro Ser Lys Val Asn Asp Cys Leu Lys Glu Val Gln Glu 785 790 795
800His Val Glu Lys Ile Ala Asp Arg Lys Asp Val Phe Thr Arg Asn Ser
805 810 815 Leu His His Ile Ser Phe Phe Val Pro Ala Lys Glu Leu Phe
Asn Cys 820 825 830 Ala Leu Ser Thr Tyr Asp Leu Lys Leu Ala Gln Gln
Val Ala Glu Ala 835 840 845 Ser Asn Tyr Asp Pro Lys Glu Tyr Leu Pro
Val Leu Asn Lys Leu Asn 850 855 860 Arg Val Met Cys Thr Leu Glu Arg
Gln Tyr Arg Ile Asn Val Val Arg 865 870 875 880Glu Ala Trp Ile Asp
Ala Val Ser Ser Leu Phe Leu Leu Asp Ser Ser 885 890 895 Lys Glu Arg
Gly Ser Glu Glu Thr Trp Trp Asn Asp Ile Glu Asp Ile 900 905 910 Ile
Ile Gln Arg Glu Lys Leu Tyr Gln Asp Ala Leu Thr Leu Val Lys 915 920
925 Pro Gly Asp Arg Arg Tyr Lys Gln Cys Cys Glu Leu Tyr Ala Glu Leu
930 935 940 Glu Arg Lys Val His Trp Arg Glu Ala Ala Leu Phe Tyr Glu
Leu Ser 945 950 955 960Gly Asn Ser Glu Lys Thr Leu Lys Cys Trp Glu
Met Ser Arg Asp Val 965 970 975 Asp Gly Leu Ala Ala Ser Ala Arg Arg
Leu Ala Val Asp Ala Gly Lys 980 985 990 Leu Lys Ile His Ala Ile Lys
Met Ser Thr Thr Leu Arg Glu Ala Arg 995 1000 1005 Gln Pro Lys Glu
Leu Ala Lys Ala Leu Lys Leu Ala Gly Ser Ser Ser 1010 1015 1020 Thr
Gln Ile Val His Val Leu Cys Asp Ala Phe Glu Trp Leu Asp Ala 1025
1030 1035 1040Ser Arg Glu Val Glu Val Gly Lys Glu Glu Ala Leu Lys
Lys Ala Ala 1045 1050 1055 Leu Ser Arg Asn Asp Gln Val Leu Met Asp
Leu Glu Arg Arg Lys Thr 1060 1065 1070 Glu Phe Glu Asn Tyr Lys Lys
Arg Leu Ala Val Val Arg Glu Asn Lys 1075 1080 1085 Leu Lys Arg Val
Glu Gln Phe Ala Ala Gly Glu Val Asp Asp Leu Arg 1090 1095 1100 Asp
Asp Ile Ser Val Ile Ser Ser Ile Ser Ser Arg Ser Gly Ser Ser 1105
1110 1115 1120Lys Val Ser Met Ala Ser Thr Val Arg Arg Lys Gln Ile
Glu Lys Lys 1125 1130 1135 Lys Ser Ser Leu Lys Glu Gly Gly Glu Tyr
Glu Asp Ser Ala Leu Leu 1140 1145 1150 Asn Val Leu Ser Glu Asn Tyr
Arg Trp Leu Glu Asn Ile Gly Ser Glu 1155 1160 1165 Phe Cys Phe Pro
Trp Asn Phe Asn Ile Leu 1170 1175 1017DNAMus sp. 10ttttttttcc
ctcagaa 171117DNAMus sp. 11tatgctttgt gaaaggt 171217DNAMus sp.
12ttttctctga tgcagct 171317DNAMus sp. 13acatgaactc ctaagct
171417DNAMus sp. 14cttgaaaaac tgtaggc 171517DNAMus sp. 15ggtgtctctc
ttcagcc 171617DNAMus sp. 16ctacctcctt tgcag ag 171717DNAMus sp.
17aggttctgct ttcagac 171817DNAMus sp. 18ttttgtccct accaggt
171917DNAMus sp. 19tccctccaca cacagtc 172017DNAMus sp. 20cttttcattg
tgtagac 172117DNAMus sp. 21ttttttgttt tctaggt 172217DNAMus sp.
22ctaatatttg aacagga 172317DNAMus sp. 23ttttttttgc tttagtt
172417DNAMus sp. 24ttaatcttac aacagag 172517DNAMus sp. 25ttcatttctt
tgcagga 172617DNAMus sp. 26tcttgcctgt tgcaggt 172717DNAMus sp.
27cactggtatt tttagtg 172817DNAMus sp. 28gggttttatt ttgagat
172917DNAMus sp. 29ttcctgtcct cacagac 173017DNAMus sp. 30tactttcttt
gataggt 173117DNAMus sp. 31tactgtggtt cttaggg 173217DNAMus sp.
32cacttactac ctcaggt 173317DNAMus sp. 33cttaaactcc aacagga
173417DNAMus sp. 34aacttttttc ctaggga 173517DNAMus sp. 35tttttttttt
ttcagga 173617DNAMus sp. 36cgtctcttgt cacaggc 173717DNAMus sp.
37ttgctgtctt ttcagga 173817DNAMus sp. 38ctcttccctt gtcagga
173917DNAMus sp. 39tttcttccct cttaggt 174017DNAMus sp. 40attatgcatc
ctcagcc 174117DNAMus sp. 41gttcatcttc tctagat 174217DNAMus sp.
42tgtaatttct gacagga 174317DNAMus sp. 43ccatttcttc tctagat
174417DNAMus sp. 44ctgttttctg cttaggt 174517DNAMus sp. 45cattcttgct
tccagat 174617DNAMus sp. 46aggtgagcat tcgcccg 174717DNAMus sp.
47aagtaggtca ctgatgc 174817DNAMus sp. 48aggtaggtgt aaggcct
174917DNAMus sp. 49aggtaagctt tgcactg 175017DNAMus sp. 50aggtaagcgt
ttcttgg 175117DNAMus sp. 51tggtaaggcg ggatgat 175217DNAMus sp.
52tggtgtctct cttcagc 175317DNAMus sp. 53aagtgagtga gcataaa
175417DNAMus sp.
54aggtaggggt cagagtt 175517DNAMus sp. 55tggtatgaca gcttgtg
175617DNAMus sp. 56aagtaagttg ctgcgaa 175717DNAMus sp. 57tggtaagtgg
aagcagg 175817DNAMus sp. 58tcgtaagttc ctaaata 175917DNAMus sp.
59aggtatcatg gttcatc 176017DNAMus sp. 60gggtgaggat cagagtt
176117DNAMus sp. 61aggtgaatag acacggc 176217DNAMus sp. 62aggtatgtag
gcttggt 176317DNAMus sp. 63aagtaagctc tcctata 176417DNAMus sp.
64aggtaagctg actcttc 176517DNAMus sp. 65aagtaagtat ttattct
176617DNAMus sp. 66aggtacactt tgcgtct 176717DNAMus sp. 67aggtaagtat
tttgata 176817DNAMus sp. 68aagtgggtgc tgtgtgt 176917DNAMus sp.
69aggtagagac ctgcgcg 177017DNAMus sp. 70aggtatgtgg agttgag
177117DNAMus sp. 71tggtaagggt ttttttt 177217DNAMus sp. 72aggtatgtgg
tgggtta 177317DNAMus sp. 73aggtaagcag ggccatt 177417DNAMus sp.
74aggtgagctc ctccccg 177517DNAMus sp. 75tggtaaggaa gctctga
177617DNAMus sp. 76aggtgaggat tacattt 177717DNAMus sp. 77gggtgagtgc
ctccaaa 177817DNAMus sp. 78gcgtacgtac gagacct 177917DNAMus sp.
79aggtatggct tcagtgc 178017DNAMus sp. 80cggtaagctt cctcaga
178117DNAMus sp. 81cggtgtactg ctcgttc 178219DNAArtificial
SequenceDescription of Artificial Sequence Primer 82gccagtgttt
ttgcctgag 198319DNAArtificial SequenceDescription of Artificial
Sequence Primer 83cggattgtca ctgttgtgc 198420DNAArtificial
SequenceDescription of Artificial Sequence Primer 84gactgctctc
atagcatcgc 208515DNAArtificial SequenceDescription of Artificial
Sequence Primer 85aagtaagygc cattg 158615DNAArtificial
SequenceDescription of Artificial Sequence Primer 86ggttcacsga
ttgtc 158717DNAArtificial SequenceDescription of Artificial
Sequence Primer 87ggcgtcgtag aaattgc 178820DNAArtificial
SequenceDescription of Artificial Sequence Primer 88gtggtgctga
aggggcaggc 208910DNAArtificial SequenceDescription of Artificial
Sequence Primer 89tacagactta 10
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