Methods and compositions of nucleic acid ligands for detection of foodborne and waterborne pathogens

Abstract

Specific DNA sequences for binding various foodborne and waterborne pathogens and biotoxins are described. Each of these sequences can function in varying assay and sensor formats with varying degrees of success.

Description

PRIORITY INFORMATION

[0001] This application is based upon and claims priority from U.S. Provisional application Ser. No. 61/372,649 filed on Aug. 11, 2010, which is incorporated herein by reference.

BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] The present invention pertains to the field of aptamer- and nucleic acid ligand (DNA and RNA ligand)-based diagnostics. More particularly, it relates to single-stranded Deoxyribonucleic acid ("DNA") and Ribonucleic acid ("RNA") ligand sequences, whether individual or linked together to form longer multiple binding site "receptors," that specifically target and bind to foodborne and waterborne pathogenic bacteria or parasites such as Campylobacter jejuni, pathogenic Escherichia coli, Listeria monocytogenes, Salmonella enterica serovar Typhimurium (formerly S. typhimurium), molds or other pathogenic fungi, Cryptosporidium and Giardia parasites and related toxins produced by some bacteria (e.g., Shiga or Vero toxins) and other virulence factors (intimins, adhesions, capsules, etc.) indicating the presence of the pathogens.

[0004] These individual or linked DNA ligand (aptamer) sequences represent valuable target analyte-responsive components of diagnostic devices or biosensors. A biosensor can be defined as any device that employs a biologically-derived molecule as the sensing component and transduces a target analyte binding event into a detectable physical signal (including, but not limited to, changes in light intensity, absorbance, emission, wavelength, color, electrical conduction, electrical resistance, or other electrical properties, etc). Once bonded with the target, these DNA ligand sequences can be used to qualitatively determine the presence of target analyte, as well as to quantify the target analyte amount, in a sample using a broad variety of assay types and diagnostic or sensor platforms including, but not limited to, affinity-based lateral flow test strips, membrane blotting, surface plasmon resonance ("SPR"), magnetic bead ("MB")-based capture, plastic-adherent sandwich assays ("PASA"), chemiluminescence ("CL"), electrochemiluminescence ("ECL"), radioisotopic, fluorescence intensity, including quantum dot ("QD") or other fluorescent nanoparticle ("FNP") of dye-based, fluorescence lifetime, and fluorescence polarization ("FP") assays or enzyme-linked (ELISA-like) microplate assays. ELISA-like assays refer to microwell or microplate assays similar to traditional "Enzyme-Linked Immunosorbent Assays" or "ELISA" in which an aptamer or nucleic acid ligand is substituted for the antibody component or components, but the other components such as peroxidase or alkaline phosphatase enzymes and color-producing substrates remain the same.

[0005] In addition, these DNA ligand sequences are valuable in competitive displacement assays which are not solely dependent on high affinity (strong attractive forces between a receptor and its ligand) or high avidity (high tensile or physical strength of receptor-ligand bonds) to produce sensitive detection (sub-nanoMolar or sub-nanogram levels), because the equilibrium constant (generally K.sub.a=10.sup.6 to 10.sup.8 to enable competition) must allow reasonable displacement of previously bound target materials to detect a change at or below nanogram or nanoMolar levels. In a competitive displacement assay, labeled DNA ligand plus labeled analyte complexes compete with unlabeled analyte to bind with the labeled DNA. After allowing the labeled and unlabeled analytes to come to equilibrium with the labeled DNA, the unlabeled target analyte may be quantitatively assayed by fluorescence intensity or other methods. Such assays would include competitive displacement fluorescence resonance energy transfer ("FRET") assays or DNA ligand "beacon" FRET assays. Each of these types of assays and detection platforms has different applications in either central laboratories or as portable detectors to identify tainted foods and water either in the field (e.g. on farms or in water supplies) or in the food processing chain progressing toward the human or animal consumer.

[0006] 2. Background Information

[0007] The DNA ligand sequences listed in Table 1 herein were derived by iterative cycles of affinity-based selection, washing, heated elution, and polymerase chain reaction ("PCR") amplification of bound DNA ligands from a randomized library using immobilized target analytes for affinity selection and PCR amplification followed by cloning and Sanger dideoxynucleotide DNA sequencing. Sanger dideoxynucleotide sequencing refers to DNA chain termination due to lack of a 3'-OH to link incoming bases with during DNA synthesis followed by automated fluorescence reading of the DNA sequence from an electrophoresis gel containing all of the terminated DNA fragments. DNA sequencing may be accomplished by PCR doped with dideoxynucleotides lacking hydroxyl groups at the 2' and 3' sugar ring positions and thereby disallowing chain formation. PCR refers to the enzymatic amplification or copying of DNA molecules with a thermo-stable DNA polymerase such as Thermus aquaticus polymerase ("Taq") with known "primer" regions or short oligonucleotides of known sequence that can hybridize to a longer target DNA sequence to enable priming of the chain reaction (exponential doubling of the DNA target copy number with each round of amplification). A randomized library can be chemically synthesized by linking together the four deoxynucleotide triphosphate bases (adenine; A, cytosine; C, guanine; G, and thymine; T) in equal amounts (25% each), so that a combinatorial oligonucleotide arises with sequence diversity equal to 4 raised to the nth power (4.sup.n) where n is the desired length of the randomized region in bases. In other words, if position 1 in an oligonucleotide is allowed to consist of A, C, G, or T (diversity=4) by equal availability of all 4 bases and these 4 possibilities are multiplied by each base linking to 4 more possible bases at position 2, then this process yields 16 possible 2-base oligonucleotides (i.e., AA, AC, AG, AT, CA, CC, CG, CT, GA, GC, GG, GT, TA, TC, TG, TT) and so on for the entire chosen length (n) of the randomized region. This combinatorial progression displays immense diversity as a function of oligonucleotide chain length. For example, an oligonucleotide decamer of 10 base length could be expected to contain 4.sup.n=4.sup.10 or 1,048,576 unique DNA sequences from which to chose or select by affinity one or more sequences that bind a given immobilized target analyte. The randomized oligonucleotide or DNA is designed to be flanked on either side by short primer regions of known and fixed sequences to enable PCR amplification (exponential copying) of the rare sequences that are selected from the random library by binding to the target after the non-binding members of the random library are washed away (not selected).

[0008] Additional assays, such as ELISA-like plate assays or fluorescence (intensity and FRET) assays, may be used to screen or verify the value of particular DNA and RNA ligands or aptamer sequences for detection of a given target analyte in a given assay format or type of biosensor. Some of the sequences operate (bind and transduce the binding signal) more effectively in affinity-based (ELISA-like or fluorescence intensity) assays, while other DNA ligand sequences against the same targets function better in competitive or other assays, thereby leading to more sensitive detection with lower limits of detection (sub-nanoMolar or sub-nanogram) and less cross-reactivity or more specificity for the target analyte. Specificity means the ability to selectively exclude molecules similar in structure to the true target analyte that may interfere with the assay and give false readings. All of the listed DNA ligand nucleotide sequences have potential applications in some type of assay format, because they have survived at least 5 rounds of affinity-based selection and enrichment (by PCR amplification), although some of the sequences will undoubtedly perform better in certain assay formats or configurations (in tubes, square cuvettes, membranes, or on biochips) than others.

[0009] Combinations of the DNA ligands whether in whole or in part (i.e., their binding sites of 5-10 or more nucleotides or bases) could be linked together in a linear or 2-dimensional or 3-dimensional fashion similar to dendrimers to bind multiple epitopes or binding sites on a complex target analyte (Ag or antigen). The advantage of linking aptamers or their shorter binding pockets, loops or binding sites is that the nascent linear, 2-D or 3-D aptamer construct will likely have improved affinity or "avidity" (tensile binding strength) making it more difficult to remove or dissociate from the target antigen. The linked aptamer complex will be likely to gain specificity as well since the probability of binding to multiple epitopes with any degree of success is multiplicative. Thus, the ability to bind to epitopes A, B and C equals the product of the probability of binding to A with high affinity times the probability of binding to B with high affinity times the probability of binding to C with high affinity and that probability is clearly much less than binding to only A, B, or C or any combination of the two epitopes therein. In this way, the specificity of aptamers or DNA ligands can be increased. This approach to binding site linkage emulates that of nature in that antibodies demonstrate linkage of their "hypervariable" (HV) regions on the antigen combining sites of the immunoglobulin light and heavy chains. In the HV regions, the variability of the 20 amino acid types is quite high and essentially represents a selection of one combination from a large combinatorial library in the protein realm. The trait of HV region linkage contributes to antibody affinity, avidity and specificity. Similarly, linking aptamers or aptamer binding sites for various epitopes in one, two or three dimensions will enhance larger aptamer or DNA ligand construct affinity, avidity, and selectivity or specificity.

[0010] All of the listed DNA ligand nucleotide sequences have potential utility in some assay format, although some of the candidate sequences will perform better in certain assay formats or configurations (in tubes, cuvettes, membranes, or on biochips) than others. Assays such as ELISA-like plate assays or fluorescence (intensity and FRET) assays, may be used to verify the utility of the DNA ligand sequences. Some of the sequences function more effectively in affinity-based (ELISA-like or fluorescence intensity) assays, while other DNA ligand sequences against the same bacterial targets or analytes function better in competitive FRET assays.

SUMMARY OF THE INVENTION

[0011] The present invention provides specific DNA sequence information as shown in Table 1 for nucleic acid ligands selected from randomized pools to bind targeted foodborne and waterborne pathogenic bacteria and toxins, which can be put into a composition useful in a variety of assay formats and sensor or diagnostic platforms to detect or quantify the targeted bacteria or toxin. While all of the candidate sequences have been shown to bind their cognate targets, some are shown to function more effectively in affinity-based assays versus fluorescence resonance energy transfer (FRET) or other assay formats that rely more on physical parameters other than affinity such as fluorophore-quencher proximity (i.e., the Forster distance). Therefore, all of the sequences are potentially valuable for detection or quantitative assays, but some may function better than others in particular assay formats.

BRIEF DESCRIPTION OF THE DRAWINGS

[0012] FIG. 1 is a graph and table comparing the FRET responses of specific DNA ligands.

[0013] FIG. 2 shows the secondary structures of two DNA ligands which both bind E. coli strain ATCC 8739, but only one loop structure in the EcO 4R DNA ligand (SEQ ID No. 88) yielded competitive FRET as illustrated by the fluorescence spectra.

[0014] FIG. 3 is a graph plotting relative fluorescence intensity against the concentration of Campylobacter jejuni bacteria detected in chicken juice by plastic-adherent DNA sandwich assay.

[0015] FIG. 4 shows graphs demonstrating detection of Salmonella enterica ATCC strain 13311 by plastic-adherent DNA sandwich assay.

[0016] FIG. 5 shows graphs demonstrating detection of Shiga toxin type 1 by plastic-adherent DNA sandwich assay.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0017] There is no single preferred embodiment for use of the DNA aptamer ligand sequences or linked aptamer constructs identified herein. Rather, the sequences are useful to varying extents in a variety of assay formats and sensors or diagnostic devices chosen from at least the following list: lateral flow test strips, ELISA-like or enzyme-linked microplate assays, magnetic bead-based capture assays, ECL or other chemiluminescence assays, radioisotopic assays and a variety of fluorescence assays including, but not limited to, fluorescence intensity, fluorescence lifetime, FP assays, and FRET assays (both beacon and competitive FRET in round tubes, square or flat cuvettes, or immobilized on magnetic beads, other types of microbeads, or flat surfaces such as nitrocellulose, nylon, or other membranes or on glass or plastic DNA microarrays or "biochips."

[0018] While there may appear to be considerable variability among sequences that bind the same clinical analyte targets, "epitopes" or binding sites are usually quite small (e.g., 5-10 bases) and a single target may contain numerous individual binding sites or epitopes for multiple aptamer binding. In addition, however, there is often a common or consensus sequence or common segments of 5-10 or more nucleotides in a row within otherwise different aptamer sequences that can bind a specific target epitope that may dominate the other binding sites by being more physically accessible or having stronger electrostatic, hydrogen bonding, or other attractive forces (summation of van der Waals or other weak forces). Variations in nucleotide sequences around these consensus segments or common binding sequence segments may serve to modulate the binding segment's affinity or specificity or may have no effect at all.

DNA Ligand (Aptamer) Selection and Generation

[0019] General methods for developing DNA ligands or aptamers to the immobilized proteins, peptides, or small molecules (defined as less than 1,000 Daltons) are as follows. The protein, peptide or an amino-derivative of the small molecule (such as glucosamine in the case of D-glucose or dextrose) is then added to 2.times.10.sup.9 tosyl-coated magnetic beads (MBs; e.g., Dynal brand from Invitrogen Corp. Carlsbad, Calif., 2.8 micron size) for 2 hours at 37.degree. C. The tosyl group is a "leaving" group that allows the formation of a very stable covalent bond between primary amine groups in the target protein, peptide or amino-derivatized small molecule and therefore immobilizes the target on the surfaces of the MBs so that they can be used to probe the randomized DNA library for DNA ligands. Target molecule-conjugated MBs (or target-MBs) are collected for 2 minutes in a magnetic collection device using an external magnet and the supernate is carefully withdrawn with a pipette tip. Target-MBs are then resuspended by vortexing briefly in 1.times. Binding Buffer (1XBB; 0.5M NaCl, 10 mM Tris-HCl, and 1 mM MgCl.sub.2, pH 7.5-7.6) and washed by agitation for 5 minutes. MBs are collected and washed three times in this manner and then resuspended in 1 ml of 1XBB.

[0020] MB-based DNA ligand or aptamer development is then performed using a template library sequence such as: 5'-ATCCGTCACACCTGCTCT-N.sub.36-TGGTGTTGGCTCCCGTAT-3', where N.sub.36 represents the randomized 36-base region of the DNA library (maximal sequence diversity=4.sup.36 in theory). Primer sequences are: 5'-ATACGGGAGCCAACACCA-3' (designated forward) and 5'-ATCCGTCACACCTGCTCT-3' (designated reverse) to prime the template and nascent strands for PCR, respectively. The random library is reconstituted in 500 .mu.l of sterile nuclease-free water and heated to 95.degree. C. for 5 minutes to ensure that the DNA library is completely single-stranded and linear. The hot DNA library solution is added to 100 .mu.l of target-MBs (2.times.10.sup.8 beads) with 600 .mu.l of sterile 2.times. Binding Buffer (2XBB). The DNA library and target-MB suspension (1.2 ml) is mixed at room temperature (RT, approximately 25.degree. C.) for 1 hour. Target-MBs with any bound DNA (round 1 aptamers) are magnetically collected. The DNA-target-MB complexes are washed three times in 400 .mu.l of sterile 1 XBB. Following the third wash, the DNA-target-MB pellet (about 75 .mu.l) is used in a PCR reaction to amplify the bound DNA as follows. The MB pellet is split into 15 .mu.l aliquots and added to five pre-made PCR tubes which contain most of the nonperishable ingredients of a PCR reaction beneath a wax seal. A total of 3 .mu.l of 1:10 primer mix (10% forward primer plus 10% reverse primer) in nuclease-free deionized water or .about.20 nanomoles of each primer per ml plus 1 .mu.l (5 U) of Taq DNA polymerase and 5 .mu.l of 2 mM MgCl.sub.2 are added to each of the five tubes. PCR reactions are supplemented with 0.5 .mu.l of E. coli single-strand binding protein (SSBP, Stratagene Inc., La Jolla, Calif.) to inhibit high molecular weight concatamer (end to end aggregates of the DNA ligands) formation. PCR is carried out as follows: an initial 95.degree. C. phase for 5 minutes, followed by 20 cycles of 1 minute at 95.degree. C., 1 minute at 53.degree. C., and 1 minute at 72.degree. C. followed by a 72.degree. C. completion stage for 7 minute, and refrigeration at 4.degree. C. This constitutes the first of multiple rounds of MB-atpamer development. Iterations of the MB-aptamer development process are repeated until the desired affinity or assay sensitivity and specificity are achieved. Typically, 5-10 rounds of the MB-aptamer development process are required to achieve low ng/ml detection of target analytes. To begin the second round and all subsequent rounds, 4 complete tubes of the 5 original PCR tubes are heated to 95.degree. C. for 5 minutes to release bound DNA from the target-MBs. The fifth tube is always retained and refrigerated as a back-up for that round of the aptamer generation process. All available DNA (25 .mu.l per tube) is siphoned out of the hot tubes without removing the target-MBs before the tubes cool significantly and the DNA is pooled. The 100 .mu.l of hot DNA is added to 100 .mu.l of fresh target-MBs in 200 .mu.l of 2XBB and allowed to mix for 1 hr at RT. Thereafter, the selection and amplification process are repeated for 3-8 more rounds with checking for 72 bp aptamer PCR products by ethidium bromide-stained 2% agarose electrophoresis after each round. Following the last round of aptamer development, aptamers are cloned into chemically competent E. coli and are sequenced.

Screening of Aptamers for Highest Affinity, Lowest Cross-Reactivity and to Determine Lower Limit of Detection by Target Titration in ELISA-like Plate Assay ("ELASA")

[0021] To evaluate, screen, and rank aptamers based on affinity against clinically relevant targets, an enzyme-linked plate assay is conducted by first immobilizing 100 .mu.l of 1:10 diluted target (about 0.1 mg of total protein, peptide or small molecule) in 0.1M NaHCO.sub.3 (pH 8.5) overnight at 4.degree. C. in a covered polystyrene 96-well plate. The plate is decanted and washed three times in 250 .mu.l of 1XBB. Each of the different 5'-biotinylated aptamers raised against the target is dissolved in 1XBB at 1.00 nmoles to 4.50 nmoles per 100 microliters and applied to their corresponding plate wells for 1 hour at room temperature (RT; .about.25.degree. C.) with gentle mixing on an orbital shaker. The plate is decanted and washed three times in 250 .mu.l of 1XBB for at least 5 minutes per wash with gentle mixing. One hundred .mu.l of a 1:2,000 dilution of streptavidin-peroxidase from a 5 mg/ml stock solution in 1XBB is added per well for 30 minutes at RT with gentle mixing. The plate is decanted and washed three times with 250 .mu.l of 1XBB per well as before. One hundred .mu.l of ABTS (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) substrate with stabilized hydrogen peroxide is added per well for 10 minute at room temperature. Finally absorbance is quantified using a microplate reader with 405 nm optical filter.

Aptamer Beacons and Competitive FRET-Aptamer Assays

[0022] Once key aptamers have been identified by the commonality of their sequences or their secondary stem-loop structures, the assay developer decides upon secondary structure loops (potential binding pockets) to label with an F or Q. Secondary stem-loop structures are generated by Gibbs free energy minimization with common software. At this point, one can assess aptamer "beacon" potential in FRET analyte titration experiments. The suspected short aptamer beacon loop is synthesized again with a fluorophore (F) such as TYE 665 attached to the 5' end and quencher (Q) such as Iowa Black attached to the 3' end (or vice versa), purified by HPLC or other form of chromatography and assessed for fluorescence output or intensity as a function of different levels of the target analyte.

[0023] Alternatively, one may label the suspected binding loops internally and place an F or a Q somewhere in the mid-section of the suspected loop other than the 3' or 5' end (i.e., intrachain FRET). Attachment of F or Q is usually accomplished via succinimide linkage of F- or Q-succinimides added to amino-modified aptamers at specifically chosen locations in the binding pockets. Primary amine linker moieties, such as UniLink.TM., can be added internally at the time of chemical synthesis of aptamers. Typically 1 mg or more of an aptamer sequence is synthesized with a primary amine linker moiety located at the approximate center of each loop structure (suspected binding pockets). Each of these internally amine-labeled aptamers is then labeled with 100 .mu.l (0.1 mg) of F-succinimide (or alternatively Q-succinimide) for 2 hours in a 37.degree. C. incubator, followed by purification through a 1XBB-equilibrated PD-10 (Sephadex G-25; GE Healthcare) column. In the meantime, an equal molar amount of amino-modified target molecule is labeled with 0.1 mg of spectrally matched Q-succinimide (to accept photons from F) at 37.degree. C. for 2 hours and then washed three times by centrifugation at 14,000 rpm for 10 minutes per wash and resuspension in 1 ml of 1XBB. "Spectrally matched" means that most of the wavelengths of light emitted by F can be effectively absorbed by Q because its absorbance spectrum largely overlaps the emission spectrum of F. Naturally, if the aptamer is labeled with a Q-succinimide in the alternate form of the assay, the amino-target must be labeled with an appropriately matched F-succinimide to be quenched when bound to the Q-labeled aptamer. Pooled one ml fractions of purified F-labeled DNA aptamers are mixed with an equimolar amount of Q-labeled-amino-target analyte (or vice versa in the alternate embodiment) for 30 minutes at RT with mixing in 1 XBB and then purified through an appropriate size-exclusion chromatography column (according to molecular weight of the combined F-aptamer plus Q-target complex) to produce a "FRET complex" consisting of bound F-aptamer plus Q-labeled target.

[0024] Generally, the aptamer beacons or FRET-aptamer complexes are then diluted to a final concentration of 1-5 .mu.g/ml in 1XBB and equally dispensed to polystyrene or methacrylate cuvettes in which 1 ml of unlabeled target at various concentrations in 1 XBB or diluted blood, plama, serum, saliva, aspirate or urine has been added already. Cuvettes are gently mixed for 15 to 20 minutes at RT prior to reading their fluorescence in the homogeneous beacon or competitive-displacement FRET assay formats using a spectrofluorometer having gratings to vary the excitation wavelength and emission scanning ability or handheld or otherwise portable fluorometer having a more restricted or fixed excitation and emission optical filter set with a range of wavelengths for excitation and emission.

Aptamer or Aptamer Binding Site Linkage in One or More Dimensions

[0025] The linkage of binding sites is beneficial in terms of enhancing receptor affinity, avidity (tensile binding strength), and selectivity versus complex targets with two or more distinct epitopes. This linkage can be sequential and linear (one-dimensional as in antibody heavy and light chain linkage of HV regions) or could be expanded into two or three dimensions much like DNA dendrimers or other more complex structures known to those skilled in the art. Linear linkage by chemical synthesis is quite facile, if one knows that aptamer DNA sequences or shorter (5-10 base) binding site sequences to be linked. One long sequence can be designed to incorporate the desired aptamers or binding sites with repetitive poly-adenine, poly-cytosine, poly-guanine, poly-thymine, poly-uridine, or other intervening sequences that are unlikely to bind the target. The length of the composite aptamer construct will be limited to about 200 bases by current chemical synthesis technology. However, biosynthesis or enzymatic synthesis by PCR or asymmetric PCR (producing predominately single-stranded DNA from a template) would not be so limited and should produce aptamer constructs up to 2,000 bases before the Taq polymerase falls off the template. In this way, very lengthy 2 kilobase aptamer constructs could be made from complementary DNA templates that would enable binding of different epitopes that are distal on the surface of relatively large objects such as whole bacterial or eukaryotic cells. Again, poly-A, C, G, T, or U or other linker nucleotide segments could be designed into the cDNA template and the resultant nascent strand to ligate aptamers or aptamer binding sites together into one contiguous linear chain.

[0026] For 2-D or 3-D linked aptamer structures a variety of linker chemistries are available, but the preferred embodiment is probably addition of a primary amine group somewhere in the mid-section of a larger multi-aptamer construct followed by covalent linkage of two or more such mulit-aptamer constructs by means of bifunctional linkers such as low levels (.ltoreq.1%) glutaraldehyde, carbodiimides, sulfo-EGS, sulfo-SMCC or other such bifunctional linkers familiar to those skilled in conjugate chemistry.

[0027] Referring to the figures, FIG. 1 is a comparison of ELISA-like affinity-based and competitive FRET assays using the same DNA ligands. It provides a graphical comparison of the same selected family of DNA ligands that bind E. coli OMPs in an ELISA-like affinity-based plate assay (data table in FIG. 1) with competitive FRET response spectra for the same population of DNA ligand sequences. It further is an illustration of how anti-E. coli OMP DNA ligands are useful in an ELISA-like assay format (tabled absorbance values) and how some candidate DNA ligand sequences show greater affinity than others (i.e., have higher absorbance values approaching 1.9) for the Crook's strain (ATCC 8739) of E. coli. The figure also demonstrates that some DNA ligand sequences with generally lower affinities (some of the shaded boxes in FIG. 1) from the same population yield a greater competitive FRET response to E. coli 8739 (i.e., are more useful in a FRET assay format, but not as useful for affinity-based assays like ELISA). The boxed values in the table of FIG. 1 show all of the highest affinity DNA ligand sequences or wells with absorbance values greater than 1.5. The shaded values indicate wells with the greatest competitive FRET responses (wells A8, A10, B2, B8, C12, and D6). It is clear from FIG. 1 that only two of the highest affinity DNA ligands in wells D6 and C12 also gave strong FRET responses, thereby illustrating the varied utility of different members of the same general DNA ligand family that binds E. coli OMPs.

[0028] FIG. 2 shows the secondary structures of two DNA ligands (as determined by Vienna RNA free energy minimization software using DNA mathematical parameters at room temperature (25.degree. C.)) shown to bind the OMPs of E. coli strain ATCC 8739 with moderate to high affinity by ELISA-like assay. However, only the loop or binding pocket of the DNA ligand designated EcO 4R (SEQ ID No. 88) was useful for competitive FRET as illustrated by the fluorescence spectra at the bottom of the figure when AlexaFluor 647-succinimide is used to label the putative binding pocket via a UniLink.TM. amine linker between bases 42 and 43 (numbered from the 5' end) and the fluorophore-labeled EcO 4R DNA molecules is bound to Black Hole Quencher (BHQ)-3-succinimide labeled E. coli ATCC 8739 and competed against decreasing levels or concentrations of unlabeled E. coli ATCC 8739 in neat buffer. None of the other loop structures in EcO 4R or EcO 5R (SEQ ID No. 90) DNA ligands were capable of producing a FRET response in this competitive FRET format.

[0029] FIG. 3 graphically illustrates an ultrasensitive detection of Campylobacter jejuni by a plastic-adherent sandwich assay. The graph plots relative fluorescence intensity against the concentration of the targeted, Campylobacter jejuni, bacteria detected in chicken juice down to a level of approximately 10 bacterial cells using a one-step plastic-adherent DNA ligand-MB/DNA ligand red QD (Q-dot 655 nm) sandwich assay. Five independent readings were taken per data point with the green (Rhodamine) channel of a fluorometer. The DNA ligand sequences may be used to detect as few as 2 live or dead C. jejuni bacterial cells (a well-known foodborne pathogen) in neat buffer and various food matrices including diluted whole milk and poultry rinsate.

[0030] In this assay, two different C. jejuni sequences (C2 and C3) from the SEQ ID NO's 1-6 were 5'-amine modified upon synthesis and attached to either 1,000 tosyl-M280 (2.8 micron diameter) Dynal (Invitrogen, Inc.) MB's or 0.24 picoliters of Q-dot 655 ITK reagent (Invitrogen, Inc.) per test. The C2 DNA ligand was used for capture on the surface of tosyl-MB's and the C3 DNA ligand was used as the reporter reagent after attachment to the Q-dot 655 ITK reagent via BS3 (bis-suberate bifunctional linker from Pierce Chemical Co.). The reagents were purified, mixed together and lyophilized in plastic cuvettes. The powered assays were later back-flushed with nitrogen and capped. Upon rehydration, the adherent one-step sandwich assays were used to detect live or dead C. jejuni cells with the very sensitive results depicted in FIG. 2 in chicken juice.

[0031] FIG. 4 demonstrates sensitive detection of the targeted Salmonella species by plastic-adherent sandwich assay in the range of 10 to 1,000 bacteria per mL. The graphs show the detection of Salmonella enterica ATCC strain 13311 in two separate trials using specific DNA ligands in a plastic-adherent DNA ligand-MB plus DNA ligand-QD dot sandwich assay format in neat buffer The particular high affinity DNA ligand sequence used for MB conjugate formation and capture was Sal 4/14R and the DNA ligand used for QD coupling and reporting was designated Sal 19F and selected from SEQ ID NO's 81-218. However, other DNA ligands from the same family give similar affinity-based results and may be useful for detection of different species or strains of Salmonella.

[0032] FIG. 5 demonstrates the ultrasensitive detection of E. coli Shiga toxins by plastic-adherent sandwich assay. The graphs show the detection of Shiga toxin type 1. from two separate trials using specific DNA ligands in a plastic-adherent DNA ligand-magnetic bead plus DNA ligand quantum dot sandwich assay format. Using the plastic-adherent aptamer-MB plus aptamer-QD conjugate sandwich assay described in FIGS. 3 and 4, similar ultrasensitive detection of Shiga or Shiga-like toxin 1 to a level of 10 ng per mL was achieved in neat buffer as shown in FIG. 5. The particular high affinity DNA ligand sequence used for MB conjugate formation and capture was Shiga 8/21F in one trial and 16F in the other and the DNA ligand used for QD coupling and reporting was designated Shiga 16F in both cases. All three of these DNA ligand sequences were selected from SEQ ID NO's 544-574. However, other DNA ligands from the same family give similar results and may be useful for detection of different species or strains of Shiga-like or Vero toxins.

[0033] Although the invention and DNA ligand sequences have been described with reference to specific embodiments, this description is not meant to be construed in a limited sense. Various modifications of the disclosed embodiments, as well as alternative embodiments of the inventions will become apparent to persons skilled in the art upon the reference to the description of the invention. It is, therefore, contemplated that the appended claims will cover such modifications that fall within the scope of the invention.

TABLE-US-00001 TABLE 1 DNA ligand Sequence ID Nos. Campylobacter jejuni OMPs - Fresh bacteria SEQ ID NO. 1 (C1) - CATCCGTCACACCTGCTCTGGGGAGGGTGGCGCCCGTCTCGGT GGTGTTGGCTCCCGTATCA SEQ ID NO. 2 (C2) - CATCCGTCACACCTGCTCTGGGATAGGGTCTCGTGCTAGATGTG GTGTTGGCTCCCGTATCA SEQ ID NO. 3 (C3) - CATCCGTCACACCTGCTCTGGACCGGCGCTTATTCCTGCTTGTG GTGTTGGCTCCCGTATCA SEQ ID NO. 4 (C4) - CATCCGTCACACCTGCTCTGGAGCTGATATTGGATGGTCCGGTG GTGTTGGCTCCCGTATCA SEQ ID NO. 5 (C5) - CATCCGTCACACCTGCTCTGCCCAGAGCAGGTGTGACGGATGTG GTGTTGGCTCCCGTATCA SEQ ID NO. 6 (C6) - CATCCGTCACACCTGCTCTGCCGGACCATCCAATATCAGCTGTG GTGTTGGCTCCCGTATCA Aged Campylobacter jejuni (ACj; Greater than one month at 4.degree. C.) SEQ ID NO. 7 (ACj-1 For) - ATACGGGAGCCAACACCAGGACCAAAATAAATAATCAC AATAAAAATGCTTCCTAGAGCAGGTGTGACGGAT SEQ ID NO. 8 (ACj-1 Rev) - ATCCGTCACACCTGCTCTAGGAAGCATTTTTATTGTGAT TATTTATTTTGGTCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 9 (ACj-2 For) - ATACGGGAGCCAACACCACGCCGGGCCATAGGCGTGTG GTAGCATACTCGTACTAGAGCAGGTGTGACGGAT SEQ ID NO. 10 (ACj-2 Rev) - ATCCGTCACACCTGCTCTAGTACGAGTATGCTACCACA CGCCTATGGCCCGGCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 11 (ACj-3 For) - ATACGGGAGCCAACACCATAGTATAAAGACCCAATTG ACAGACTATCCTAGGCTAGAGCAGGTGTGACGGAT SEQ ID NO. 12 (ACj-3 Rev) - ATCCGTCACACCTGCTCTAGCCTAGGATAGTCTGTCAA TTGGGTCTTTATACTATGGTGTTGGCTCCCGTAT SEQ ID NO. 13 (ACj-4 For) - ATACGGGAGCCAACACCAAGAGGGGACAGAGGGTATA AGACAACTATTCTCCCCAGAGCAGGTGTGACGGAT SEQ ID NO. 14 (ACj-4 Rev) - ATCCGTCACACCTGCTCTGGGGAGAATAGTTGTCTTAT ACCCTCTGTCCCCTCTTGGTGTTGGCTCCCGTAT SEQ ID NO. 15 (ACj-7 For) - ATACGGGAGCCAACACCAGGCGGCCGCAACTTGGTCC CCTCTTCATCCTCGGATAGAGCAGGTGTGACGGAT SEQ ID NO. 16 (ACj-7 Rev) - ATCCGTCACACCTGCTCTATCCGAGGATGAAGAGGGG ACCAAGTTGCGGCCGCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 17 (ACj-8 For (69)) - ATACGGGAGCCAACACCATAGTGTTGGACCAA TACGGTAACGTGTCCTTGGAGAGCAGGTGTGACGGAT SEQ ID NO. 18 (ACj-8 Rev (69)) - ATCCGTCACACCTGCTCTCCAAGGACACGTTA CCGTATTGGTCCAACACTATGGTGTTGGCTCCCGTAT SEQ ID NO. 19 (ACj-9 For) - ATACGGGAGCCAACACCACGCGATACAATGTGCTAAA AAAGTTCGTGCCCCTGCAGAGCAGGTGTGACGGAT SEQ ID NO. 20 (ACj-9 Rev) - ATCCGTCACACCTGCTCTGCAGGGGCACGAACTTTTTT AGCACATTGTATCGCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 21 (ACj-10 For) - ATACGGGAGCCAACACCACGCCGAATAGTGTTCGTAT GCCACCCGCACGTGTCTAGAGCAGGTGTGACGGAT SEQ ID NO. 22 (ACj-10 Rev) - ATCCGTCACACCTGCTCTAGACACGTGCGGGTGGCAT ACGAACACTATTCGGCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 23 (ACj-11 For) - ATACGGGAGCCAACACCAGGCATGACTAAAAAGGAT AACCTAATCTCTTGTTCCAGAGCAGGTGTGACGGAT SEQ ID NO. 24 (ACj-11 Rev) - ATCCGTCACACCTGCTCTGGAACAAGAGATTAGGTTA TCCTTTTTAGTCATGCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 25 (ACj-15 For) - ATACGGGAGCCAACACCATACAGTCCACCGTATACTA GTGGTACCCAGGCGTCGAGAGCAGGTGTGACGGAT SEQ ID NO. 26 (ACj-15 Rev) - ATCCGTCACACCTGCTCTCGACGCCTGGGTACCACTA GTATACGGTGGACTGTATGGTGTTGGCTCCCGTAT SEQ ID NO. 27 (ACj-16 For) - ATACGGGAGCCAACACCAGGGGGCGAACAGTTACCC TTGGTCTGGACCACTGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 28 (ACj-16 Rev) - ATCCGTCACACCTGCTCTGGCAGTGGTCCAGACCAAG GGTAACTGTTCGCCCCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 29 (ACj-17 For) - ATACGGGAGCCAACACCAGGGGCGTCGGGCCAGGCG ACGGCCGCCGTTTCCGGCAGAGCAGGTGTGACGGAT SEQ ID NO. 30 (ACj-17 Rev) - ATCCGTCACACCTGCTCTGCCGGAAACGGCGGCCGTC GCCTGGCCCGACGCCCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 31 (ACj-18 For) - ATACGGGAGCCAACACCACGGGCCGTCCCTGGCCCG GGGGGGCGAAACGCGCTGAGAGCAGGTGTGACGGAT SEQ ID NO. 32 (ACj-18 Rev) - ATCCGTCACACCTGCTCTCAGCGCGTTTCGCCCCCCC GGGCCAGGGACGGCCCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 33 (ACj-19 For) - ATACGGGAGCCAACACCAGGCGATTACTAAGGGAAA AAAGTGTAAAACCTACCCAGAGCAGGTGTGACGGAT SEQ ID NO. 34 (ACj-19 Rev) - ATCCGTCACACCTGCTCTGGGTAGGTTTTACACTTTT TTCCCTTAGTAATCGCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 35 (ACj-24 For) - ATACGGGAGCCAACACCACCACCCACTGGCCCGGTC CGCGGCCGCGCGCGCCCCAGAGCAGGTGTGACGGAT SEQ ID NO. 36 (ACj-24 Rev) - ATCCGTCACACCTGCTCTGGGGCGCGCGCGGCCGCG GACCGGGCCAGTGGGTGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 37 (ACj-25 For) - ATACGGGAGCCAACACCAACGATATCCCTGACCAAA GACGTTAAATGCTTCCATAGAGCAGGTGTGACGGAT SEQ ID NO. 38 (ACj-25 Rev) - ATCCGTCACACCTGCTCTATGGAAGCATTTAACGTCT TTGGTCAGGGATATCGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 39 (ACj-26 For) - ATACGGGAGCCAACACCAGGGCGGGGGGTTGGCGAG CAGGAATCGAGAGAGGTGAGAGCAGGTGTGACGGAT SEQ ID NO. 40 (ACj-26 Rev) - ATCCGTCACACCTGCTCTCACCTCTCTCGATTCCTG CTCGCCAACCCCCCGCCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 41 (ACj-27 For) - ATACGGGAGCCAACACCAGATGCGCTTCCTGTAATGA ACAGATCATATTTATGTAGAGCAGGTGTGACGGAT SEQ ID NO. 42 (ACj-27 Rev) - ATCCGTCACACCTGCTCTACATAAATATGATCTGTTC ATTACAGGAAGCGCATCTGGTGTTGGCTCCCGTAT SEQ ID NO. 43 (ACj-28 For) - ATACGGGAGCCAACACCAAGGTAGGTTGCCGCAGGT TGGCGACAAACCAGGTTGAGAGCAGGTGTGACGGAT SEQ ID NO. 44 (ACj-28 Rev) - ATCCGTCACACCTGCTCTCAACCTGGTTTGTCGCCAA CCTGCGGCAACCTACCTTGGTGTTGGCTCCCGTAT SEQ ID NO. 45 (ACj-30 For (69)) - ATACGGGAGCCAACACCATAGTGTTGGACCA ATACGGTAACGTGTCCTTGGAGAGCAGGTGTGACGGAT SEQ ID NO. 46 (ACj-30 Rev (69)) - ATCCGTCACACCTGCTCTCCAAGGACACGTT ACCGTATTGGTCCAACACTATGGTGTTGGCTCCCGTAT SEQ ID NO. 47 (ACj-33 For) - ATACGGGAGCCAACACCACCCGGGTGGCGGGGTGGG TGTGGGTCGACGTTCTGGAGAGCAGGTGTGACGGAT SEQ ID NO. 48 (ACj-33 Rev) - ATCCGTCACACCTGCTCTCCAGAACGTCGACCCACAC CCACCCCGCCACCCGGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 49 (ACj-34 For) - ATACGGGAGCCAACACCAGGGGGGGGTGGCCGCAGG AAATATGCAGTCCACTATAGAGCAGGTGTGACGGAT SEQ ID NO. 50 (ACj-34 Rev) - ATCCGTCACACCTGCTCTATAGTGGACTGCATATTTC CTGCGGCCACCCCCCCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 51 (ACj-35 For) - ATACGGGAGCCAACACCACACACCGGGCCCGCCCCC AGCGCCCCCCTACGCACAAGAGCAGGTGTGACGGAT SEQ ID NO. 52 (ACj-35 Rev) - ATCCGTCACACCTGCTCTTGTGCGTAGGGGGGCGCTG GGGGCGGGCCCGGTGTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 53 (ACj-38 For) - ATACGGGAGCCAACACCATGAAGGAAACCTTGATAG CAGGAATAGTCCATTCCCAGAGCAGGTGTGACGGAT SEQ ID NO. 54 (ACj-38 Rev) - ATCCGTCACACCTGCTCTGGGAATGGACTATTCCTGC TATCAAGGTTTCCTTCATGGTGTTGGCTCCCGTAT SEQ ID NO. 55 (ACj-39 For) - ATACGGGAGCCAACACCACCCGGGTGGCGGGGTGGG TGTGGGTCGACGTTCTGGAGAGCAGGTGTGACGGAT SEQ ID NO. 56 (ACj-39 Rev) - ATCCGTCACACCTGCTCTCCAGAACGTCGACCCACA CCCACCCCGCCACCCGGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 57 (ACj-40 For) - ATACGGGAGCCAACACCACGCCCGCCGGCGACTCGC TCCACTCCGTCCCGCTCCAGAGCAGGTGTGACGGAT SEQ ID NO. 58 (ACj-40 Rev) - ATCCGTCACACCTGCTCTGGAGCGGGACGGAGTGGA GCGAGTCGCCGGCGGGCGTGGTGTTGGCTCCCGTAT Enterococcus faecalis Teichoic Acid (TA) DNA ligands SEQ ID NO. 59 (TA5F) - CATTCACCACACCTCTGCTGGCTTGGCTAGCCTTGATGCTA AACGACCCATAGTGTGGTGTCGTCCCGTATC SEQ ID NO. 60 (TA5R) - GATACGGGACGACACCACACTATGGGTCGTTTAGCATCAA GGCTAGCCAAGCCAGCAGAGGTGTGGTGAATG SEQ ID NO. 61 (TA6F) - CATTCACCACACCTCTGCTGGAGGAGGAAGTGGTCTGGAG TTACTTGACATAGTGTGGTGTCGTCCCGTATC SEQ ID NO. 62 (TA6R) - GATACGGGACGACACCACACTATGTCAAGTAACTCCAGAC CACTTCCTCCTCCAGCAGAGGTGTGGTGAATG SEQ ID NO. 63 (TA7F) - CATTCACCACACCTCTGCTGGACGGAAACAATCCCCGGGTA CGAGAATCAGGGTGTGGTGTCGTCCCGTATC SEQ ID NO. 64 (TA7R) - GATACGGGACGACACCACACCCTGATTCTCGTACCCGGGGA TTGTTTCCGTCCAGCAGAGGTGTGGTGAATG SEQ ID NO. 65 (TA9F) - CATTCACCACACCTCTGCTGGAAACCTACCATTAATGAGAC ATGATGCGGTGGTGTGGTGTCGTCCCGTATC SEQ ID NO. 66 (TA9R) - GATACGGGACGACACCACACCACCGCATCATGTCTCATTAA TGGTAGGTTTCCAGCAGAGGTGTGGTGAATG E. coli O157 Lipopolysaccharide (LPS) DNA ligands SEQ ID NO. 67 (E-5F) - ATCCGTCACACCTGCTCTGGTGGAATGGACTAAGCTAGCTAG CGTTTTAAAAGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 68 (E-11F) - ATCCGTCACACCTGCTCTGTAAGGGGGGGGAATCGCTTTCG TCTTAAGATGACATGGTGTTGGCTCCCGTAT SEQ ID NO. 69 (E-12F) - ATCCGTCACACCTGCTCTGCCGGACCATCCAATATCAGCTG TGGTGTTGGCTCCCGTAT SEQ ID NO. 70 (E-16F) - ATCCGTCACACCTGCTCTATCCGTCACGCCTGCTCTATCCG TCACACCTGCTCTGGTGTTGGCTCCCGTAT SEQ ID NO. 71 (E-17F) - ATCCGTCACACCTGCTCTATCAAATGTGCAGATATCAAGA CGATTTGTACAAGATGGTGTTGGCTCCCGTAT SEQ ID NO. 72 (E-18F) - ATCCGTCACACCTGCTCTGTAGATGGCAAGGCATAAGCGT CCGGAACGATAGAATGGTGTTGGCTCCCGTAT SEQ ID NO. 73 (E-19F) - ATCCGTCACACCTGCTCTGTAGATGGCAAGGCATAAGCGTC CGGAACGATAGAATGGTGTTGGCTCCCGTAT SEQ ID NO. 74 (E-5R) - ATACGGGAGCCAACACCACCTTTTAAAACGCTAGCTAGCTT AGTCCATTCCACCAGAGCAGGTGTGACGGAT SEQ ID NO. 75 (E-11R) - ATACGGGAGCCAACACCATGTCATCTTAAGACGAAAGCGA TTCCCCCCCCTTACAGAGCAGGTGTGACGGAT SEQ ID NO. 76 (E-12R) - ATACGGGAGCCAACACCACAGCTGATATTGGATGGTCCGG CAGAGCAGGTGTGACGGAT SEQ ID NO. 77 (E-16R) - ATACGGGAGCCAACACCAGAGCAGGTGTGACGGATAGAGC AGGCGTGACGGATAGAGCAGGTGTGACGGAT SEQ ID NO. 78 (E-17R) - ATACGGGAGCCAACACCATCTTGTACAAATCGTCTTGATAT CTGCACATTTGATAGAGCAGGTGTGACGGAT SEQ ID NO. 79 (E-18R) - ATACGGGAGCCAACACCATTCTATCGTTCCGGACGCTTATG CCTTGCCATCTACAGAGCAGGTGTGACGGAT SEQ ID NO. 80 (E-19R) - ATACGGGAGCCAACACCATTCTATCGTTCCGGACGCTTAT GCCTTGCCATCTACAGAGCAGGTGTGACGGAT E. coli Outer Membrane Proteins (OMPs) - Fresh Bacteria

SEQ ID NO. 81 (EcO-1F) - ATACGGGAGCCAACACCATGGTACAAGCAAACCAATAT TAGGGCCCAGACATCGAGAGCAGGTGTGACGGAT SEQ ID NO. 82 (EcO-1R) - ATCCGTCACACCTGCTCTCGATGTCTGGGCCCTAATATT GGTTTGCTTGTACCATGGTGTTGGCTCCCGTAT SEQ ID NO. 83 (EcO-2F) - ATACGGGAGCCAACACCATGATACCCTAAGGTAGGGGA GGCCTAAGCGCCACGTAGAGCAGGTGTGACGGAT SEQ ID NO. 84 (EcO-2R) - ATCCGTCACACCTGCTCTACGTGGCGCTTAGGCCTCCCC TACCTTAGGGTATCATGGTGTTGGCTCCCGTAT SEQ ID NO. 85 (EcO-3F) - ATACGGGAGCCAACACCACGCATCCCCCGCCGGGCCC GCGCCCCGCTCGCAGACAGAGCAGGTGTGACGGAT SEQ ID NO. 86 (EcO-3R) - ATCCGTCACACCTGCTCTGTCTGCGAGCGGGGCGCGGGC CCGGCGGGGGATGCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 87 (EcO-4F (73)) - ATACGGGAGCCAACACCATAATATGCCGTAAGGAG AGGCCTGTTGGGAGCGCCGTAGAGCAGGTGTGACGGAT SEQ ID NO. 88 (EcO-4R (73)) - ATCCGTCACACCTGCTCTACGGCGCTCCCAACAGGC CTCTCCTTACGGCATATTATGGTGTTGGCTCCCGTAT SEQ ID NO. 89 (EcO-5F) - ATACGGGAGCCAACACCAGGAAAAAAAGAGCCTGTGAA GATTGTAATATCAGTTAGAGCAGGTGTGACGGAT SEQ ID NO. 90 (EcO-5R) - ATCCGTCACACCTGCTCTAACTGATATTACAATCTTCAC AGGCTCTTTTTTTCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 91 (EcO-7Fa) - ATCCGTCACACCTGCTCTCGGAGGTAGACTAGGATTGC GGCGGGGGGTCAGGTATGGTGTTGGCTCCCGTAT SEQ ID NO. 92 (EcO-7Fb) - ATACGGGAGCCAACACCACAAAAGCCTTACCTAACTGC CAACAATGAATAGCAAGAGCAGGTGTGACGGAT SEQ ID NO. 93 (EcO-7Ra) - ATCCGTCACACCTGCTCTTGCTATTCATTGTTGGCAGTT AGGTAAGGCTTTTGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 94 (EcO-7Rb) - ATACGGGAGCCAACACCATACCTGACCCCCCGCCGCAA TCCTAGTCTACCTCCGAGAGCAGGTGTGACGGAT SEQ ID NO. 95 (EcO-8F) - ATACGGGAGCCAACACCACGACTAACACGACCGTTGGG GGGGGCTCGCGCGGGCAGAGCAGGTGTGACGGAT SEQ ID NO. 96 (EcO-8R) - ATCCGTCACACCTGCTCTGCCCGCGCGAGCCCCCCCCAA CGGTCGTGTTAGTCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 97 (EcO-9F) - ATACGGGAGCCAACACCAGTCCCCGCCCAGCCGTGAGC CGTACCCCCGCACACCAGAGCAGGTGTGACGGAT SEQ ID NO. 98 (EcO-9R) - ATCCGTCACACCTGCTCTGGTGTGCGGGGGTACGGCTCA CGGCTGGGCGGGGACTGGTGTTGGCTCCCGTAT SEQ ID NO. 99 (EcO-10F) - ATCCGTCACACCTGCTCTCAAGGTTGGGCCTGCAAGAG CAAAAACGGGGCGGGATGGTGTTGGCTCCCGTAT SEQ ID NO. 100 (EcO-10R) - ATACGGGAGCCAACACCATCCCGCCCCGTTTTTGCTCT TGCAGGCCCAACCTTGAGAGCAGGTGTGACGGAT SEQ ID NO. 101 (EcO-11F) - ATCCGTCACACCTGCTCTACTTGGCTTGCGACTATTAT TCACAGGGCCAAAGACTGGTGTTGGCTCCCGTAT SEQ ID NO. 102 (EcO-11R) - ATACGGGAGCCAACACCAGTCTTTGGCCCTGTGAATA ATAGTCGCAAGCCAAGTAGAGCAGGTGTGACGGAT SEQ ID NO. 103 (EcO-12/37/60F (69)) - ATACGGGAGCCAACACCATAGTGTTGGA CCAATACGGTAACGTGTCCTTGGAGAGCAGGTGTGACGGAT SEQ ID NO. 104 (EcO-12/37/60R (69)) - ATCCGTCACACCTGCTCTCCAAGGACAC GTTACCGTATTGGTCCAACACTATGGTGTTGGCTCCCGTAT SEQ ID NO. 105 (EcO-17F) - ATCCGTCACACCTGCTCTTGGAATGTCGGTGTTTTTCC AATTCCTTGGGTCGTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 106 (EcO-17R) - ATACGGGAGCCAACACCACACGACCCAAGGAATTGG AAAAACACCGACATTCCAAGAGCAGGTGTGACGGAT SEQ ID NO. 107 (EcO-18F) - ATCCGTCACACCTGCTCTGCGACGGCGACGCGGTCCG GGCGGGGGTGGAGGACGTGGTGTTGGCTCCCGTAT SEQ ID NO. 108 (EcO-18R) - ATACGGGAGCCAACACCACGTCCTCCACCCCCGCCCG GACCGCGTCGCCGTCGCAGAGCAGGTGTGACGGAT SEQ ID NO. 109 (EcO-19Fa) - ATACGGGAGCCAACACCAGAGGGTTCTAGGGTCACT TCCATGAGAATGGCTCACAGAGCAGGTGTGACGGAT SEQ ID NO. 110 (EcO-19Fb) - ATCCGTCACACCTGCTCTGGCCTGGGGACGCGAGGG AGGCGGGGGGAGTCGTGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 111 (EcO-19Ra) - ATACGGGAGCCAACACCACCACGACTCCCCCCGCCT CCCTCGCGTCCCCAGGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 112 (EcO-19Rb) - ATCCGTCACACCTGCTCTGTGAGCCATTCTCATGGAA GTGACCCTAGAACCCTCTGGTGTTGGCTCCCGTAT SEQ ID NO. 113 (EcO-20F)ATCCGTCACACCTGCTCTCACAGGGCCTCTTACTATACA GTTCTCCAGCGCTGCTGGTGTTGGCTCCCGTAT SEQ ID NO. 114 (EcO-20R) - ATACGGGAGCCAACACCAGCAGCGCTGGAGAACTGTA TAGTAAGAGGCCCTGTG GAGCAGGTGTGACGGAT SEQ ID NO. 115 (EcO-21F) - ATCCGTCACACCTGCTCTGCACGGGCTCAGTTTGGCTT TGTATCCTAAGAGAGATGGTGTTGGCTCCCGTAT SEQ ID NO. 116 (EcO-21R) - ATACGGGAGCCAACACCATCTCTCTTAGGATACAAAG CCAAACTGAGCCCGTGCAGAGCAGGTGTGACGGAT SEQ ID NO. 117 (EcO-22F) - ATACGGGAGCCAACACCAGGGGTGGCGAACATGGTAT AACTTGATAAGTGTGAAGAGCAGGTGTGACGGAT SEQ ID NO. 118 (EcO-22R) - ATCCGTCACACCTGCTCTTCACACTTATCAAGTTATAC CATGTTCGCCACCCCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 119 (EcO-23F) - ATACGGGAGCCAACACCACTCCGACACCGGCCGCCGG CACCACCCACTCCCCCTAGAGCAGGTGTGACGGAT SEQ ID NO. 120 (EcO-23R) - ATCCGTCACACCTGCTCTAGGGGGAGTGGGTGGTGCC GGCGGCCGGTGTCGGAGTGGTGTTGGCTCCCGTAT SEQ ID NO. 121 (EcO-24F) - ATACGGGAGCCAACACCATCCGGCGCGCCCTCCTCCC CCACTGCTCCCCGCCCGAGAGCAGGTGTGACGGAT SEQ ID NO. 122 (EcO-24R) - ATCCGTCACACCTGCTCTCGGGCGGGGAGCAGTGGGG GAGGAGGGCGCGCCGGATGGTGTTGGCTCCCGTAT SEQ ID NO. 123 (EcO-25F) - ATACGGGAGCCAACACCATACGCAGAGGTCCCCTACC CAGGCCAGCCGGATGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 124 (EcO-25R) - ATCCGTCACACCTGCTCTGGCATCCGGCTGGCCTGGG TAGGGGACCTCTGCGTATGGTGTTGGCTCCCGTAT SEQ ID NO. 125 EcO-26 F - ATACGGGAGCCAACACCACGAGGATTACAACTTTATGC GTGCAACCAGACACCAAGAGCAGGTGTGACGGAT SEQ ID NO. 126 EcO-26 R - ATCCGTCACACCTGCTCTTGGTGTCTGGTTGCACGCATA AAGTTGTAATCCTCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 127 EcO-27 F - ATACGGGAGCCAACACCATATAAACGAGGAAATAAAA CTGCAGAACACTTCCTCAGAGCAGGTGTGACGGAT SEQ ID NO. 128 EcO-27 R - ATCCGTCACACCTGCTCTGAGGAAGTGTTCTGCAGTTTT ATTTCCTCGTTTATATGGTGTTGGCTCCCGTAT SEQ ID NO. 129 EcO-28 F(71) - ATACGGGAGCCAACACCATCACGGCAATGTCCCGA TAATGTCTTGCTTCAGCGAGAGCAGGTGTGACGGAT SEQ ID NO. 130 EcO-28 R(71) - ATCCGTCACACCTGCTCTCGCTGAAGCAAGACATTA TCGGGACATTGCCGTGATGGTGTTGGCTCCCGTAT SEQ ID NO. 131 EcO-29 F - ATACGGGAGCCAACACCAAGCAATCAGTATACCCACCC GTCAAAAACATCATGCAGAGCAGGTGTGACGGAT SEQ ID NO. 132 EcO-29 R - ATCCGTCACACCTGCTCTGCATGATGTTTTTGACGGGTG GGTATACTGATTGCTTGGTGTTGGCTCCCGTAT SEQ ID NO. 133 EcO-30 F - ATACGGGAGCCAACACCACGGCTTCTTGCGCCCCCCCG CGCCCGCGCCCCCCCCAGAGCAGGTGTGACGGAT SEQ ID NO. 134 EcO-30 R - ATCCGTCACACCTGCTCTGGGGGGGGCGCGGGCGCGG GGGGGCGCAAGAAGCCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 135 EcO-31 F - ATACGGGAGCCAACACCAACGGAGGATGAAGAGATAA AGTAAATATCCGGGGGCAGAGCAGGTGTGACGGAT SEQ ID NO. 136 EcO-31 R - ATCCGTCACACCTGCTCTGCCCCCGGATATTTACTTTAT CTCTTCATCCTCCGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 137 EcO-32 F - ATACGGGAGCCAACACCACCCGTGGCCTTCACCCAGCC AGGGGCCCCGTCTCTGAGAGCAGGTGTGACGGAT SEQ ID NO. 138 EcO-32 R - ATCCGTCACACCTGCTCTCAGAGACGGGGCCCCTGGCT GGGTGAAGGCCACGGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 139 EcO-33 F - ATACGGGAGCCAACACCACACTACCGTCCCACCCCCTC CCAGCTCCTCCGGCCGAGAGCAGGTGTGACGGAT SEQ ID NO. 140 EcO-33 R - ATCCGTCACACCTGCTCTCGGCCGGAGGAGCTGGGAG GGGGTGGGACGGTAGTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 141 EcO-34 F - ATACGGGAGCCAACACCAATCCCCCGCCTGCGACCGAT GCACTCCCATATGTCGAGAGCAGGTGTGACGGAT SEQ ID NO. 142 EcO-34 R - ATCCGTCACACCTGCTCTCGACATATGGGAGTGCATCG G TCGCAGGCGGGGGATTGGTGTTGGCTCCCGTAT SEQ ID NO. 143 EcO-35 F - ATACGGGAGCCAACACCATACATGCCCAAGGTTTCGGG TGAGGCTACCGTGAGTAGAGCAGGTGTGACGGAT SEQ ID NO. 144 EcO-35 R - ATCCGTCACACCTGCTCTACTCACGGTAGCCTCACCCG AAACCTTGGGCATGTATGGTGTTGGCTCCCGTAT SEQ ID NO. 145 EcO-36 F - ATACGGGAGCCAACACCATTTATGTTTCATACTTTAAAC TTGGTCGTTTGCGATAGAGCAGGTGTGACGGAT SEQ ID NO. 146 EcO-36 R - ATCCGTCACACCTGCTCTATCGCAAACGACCAAGTTTA AAGTATGAAACATAAATGGTGTTGGCTCCCGTAT SEQ ID NO. 147 EcO-38 F - ATACGGGAGCCAACACCAGGCGTTTAATAATCGGAGCG ACAAATTCTACGCTGTAGAGCAGGTGTGACGGAT SEQ ID NO. 148 EcO-38 R - ATCCGTCACACCTGCTCTACAGCGTAGAATTTGTCGCT CCGATTATTAAACGCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 149 EcO-40/41B F - ATACGGGAGCCAACACCACGGCAACTTCAAACCCA AGACTAAGAAAAGCTCGTGAGAGCAGGTGTGACGGAT SEQ ID NO. 150 EcO-40/41B R - ATCCGTCACACCTGCTCTCACGAGCTTTTCTTAGTC TTGGGTTTGAAGTTGCCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 151 EcO-41A F - ATACGGGAGCCAACACCATTGTAGGCGGATATTAGAC AAGACCGAATTCCATGGAGAGCAGGTGTGACGGAT SEQ ID NO. 152 EcO-41A R - ATCCGTCACACCTGCTCTCCATGGAATTCGGTCTTGTC TAATATCCGCCTACAATGGTGTTGGCTCCCGTAT SEQ ID NO. 153 EcO-42/43A F - ATACGGGAGCCAACACCAGTAGGCTAAAGTGAGG TTAATTATGTCGACAAGGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 154 EcO-42/43A R - ATCCGTCACACCTGCTCTGGCCTTGTCGACATAATT AACCTCACTTTAGCCTACTGGTGTTGGCTCCCGTAT SEQ ID NO. 155 EcO-43B F - ATACGGGAGCCAACACCACCTCGCCCAGACGCCGGG CCCTCCCCGCCCCACCCCAGAGCAGGTGTGACGGAT SEQ ID NO. 156 EcO-43B R - ATCCGTCACACCTGCTCTGGGGTGGGGCGGGGAGGG CCCGGCGTCTGGGCGAGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 157 EcO-44 F - ATACGGGAGCCAACACCAGGTATTGGAGCTATACACGT TAACCACCGCTATTGCAGAGCAGGTGTGACGGAT SEQ ID NO. 158 EcO-44 R - ATCCGTCACACCTGCTCTGCAATAGCGGTGGTTAACGT GTATAGCTCCAATACCTGGTGTTGGCTCCCGTAT SEQ ID NO. 159 EcO-45 F - ATACGGGAGCCAACACCACGCGGGGCGGGGGGGCTGG TCGCGCGGGCCTGGCGGAGAGCAGGTGTGACGGAT SEQ ID NO. 160 EcO-45 F - ATCCGTCACACCTGCTCTCCGCCAGGCCCGCGCGACCA GCCCCCCCGCCCCGCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 161 EcO-46 F - ATACGGGAGCCAACACCAAACATTGGAACAACAAACG CTAATACACGATCGCATAGAGCAGGTGTGACGGAT SEQ ID NO. 162 EcO-46 R - ATCCGTCACACCTGCTCTATGCGATCGTGTATTAGCGTT TGTTGTTCCAATGTTTGGTGTTGGCTCCCGTAT SEQ ID NO. 163 EcO-47 F - ATACGGGAGCCAACACCAATAGATGGATAAGGGGGA A ACTGCCATTCGGTTAGTAGAGCAGGTGTGACGGAT SEQ ID NO. 164 EcO-47 R - ATCCGTCACACCTGCTCTACTAACCGAATGGCAGTTTC CCCCTTATCCATCTATTGGTGTTGGCTCCCGTAT

SEQ ID NO. 165 EcO-48 F - ATACGGGAGCCAACACCAACCAACGAAGAAGGGTCAG ACAAAAAGGAGTTCTCGAGAGCAGGTGTGACGGAT SEQ ID NO. 166 EcO-48 R - ATCCGTCACACCTGCTCTCGAGAACTCCTTTTTGTCTGA CCCTTCTTCGTTGGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 167 EcO-49 F - ATACGGGAGCCAACACCACAACAGTCAGATTGCAACT GAGTAGTACATACGTTAAGAGCAGGTGTGACGGAT SEQ ID NO. 168 EcO-49 R - ATCCGTCACACCTGCTCTTAACGTATGTACTACTCAGTT GCAATCTGACTGTTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 169 EcO-50 F - ATACGGGAGCCAACACCATAAACCAAGGGTGTAACAG AAATGATGTGACCAGGCAGAGCAGGTGTGACGGAT SEQ ID NO. 170 EcO-50 R - ATCCGTCACACCTGCTCTGCCTGGTCACATCATTTCTGT TACACCCTTGGTTTATGGTGTTGGCTCCCGTAT SEQ ID NO. 171 EcO-51 F - ATACGGGAGCCAACACCATCATTGCGACATTGAATTCA GAAGGAGGAGTGGTGTAGAGCAGGTGTGACGGAT SEQ ID NO. 172 EcO-51 R - ATCCGTCACACCTGCTCTACACCACTCCTCCTTCTGAAT TCAATGTCGCAATGATGGTGTTGGCTCCCGTAT SEQ ID NO. 173 EcO-52 F (71) - ATACGGGAGCCAACACCAGAGAATTACAACAGGTT AAGTAGTGTGACGATCATAGAGCAGGTGTGACGGAT SEQ ID NO. 174 EcO-52 R (71) - ATCCGTCACACCTGCTCTATGATCGTCACACTACT TAACCTGTTGTAATTCTCTGGTGTTGGCTCCCGTAT SEQ ID NO. 175 EcO-53 F - ATACGGGAGCCAACACCACGGCGGAACACATGGAACA CCGAATAATGTGGCTTAAGAGCAGGTGTGACGGAT SEQ ID NO. 176 EcO-53 R - ATCCGTCACACCTGCTCTTAAGCCACATTATTCGGTGTT CCATGTGTTCCGCCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 177 EcO-54 F - ATACGGGAGCCAACACCAGCGTGGTGGACGTATAACAA GACAGAAGTAACCCGTAGAGCAGGTGTGACGGAT SEQ ID NO. 178 EcO-54 R - ATCCGTCACACCTGCTCTACGGGTTACTTCTGTCTTGTT ATACGTCCACCACGCTGGTGTTGGCTCCCGTAT SEQ ID NO. 179 EcO-55 R (71) - ATACGGGAGCCAACACCATGACAAACATCAATGCA GCAAAGACTAGCAACGTGAGAGCAGGTGTGACGGAT SEQ ID NO. 180 EcO-55 F (71) - ATCCGTCACACCTGCTCTCACGTTGCTAGTCTTTG CTGCATTGATGTTTGTCATGGTGTTGGCTCCCGTAT SEQ ID NO. 181 EcO-56 F (71) - ATACGGGAGCCAACACCAGCCGGCAATGGCTGAG AGAGAATAGAGCGTGGTATAGAGCAGGTGTGACGGAT SEQ ID NO. 182 EcO-56 R (71) - ATCCGTCACACCTGCTCTATACCACGCTCTATTCT CTCTCAGCCATTGCCGGCTGGTGTTGGCTCCCGTAT SEQ ID NO. 183 EcO-57 F - ATACGGGAGCCAACACCAAGGGGGCGGCGAGTCGTAG CGTCGATAATACTGGACAGAGCAGGTGTGACGGAT SEQ ID NO. 184 EcO-57 R - ATCCGTCACACCTGCTCTGTCCAGTATTATCGACGCTA CGACTCGCCGCCCCCTTGGTGTTGGCTCCCGTAT SEQ ID NO. 185 EcO-58 F - ATACGGGAGCCAACACCAGCCCGGAGCCCTTCGTCTGC CCGCAGTCCAGTGTATAGAGCAGGTGTGACGGAT SEQ ID NO. 186 EcO-58 R - ATCCGTCACACCTGCTCTATACACTGGACTGCGGGCAG ACGAAGGGCTCCGGGCTGGTGTTGGCTCCCGTAT SEQ ID NO. 187 EcO-59 F - ATACGGGAGCCAACACCATCCGCGCCCCCGCGGCATCC GCTCACGCGTCCCGGCAGAGCAGGTGTGACGGAT SEQ ID NO. 188 EcO-59 R - ATCCGTCACACCTGCTCTGCCGGGACGCGTGAGCGGAT GCCGCGGGGGCGCGGATGGTGTTGGCTCCCGTAT SEQ ID NO. 189 EcO-60B F - ATACGGGAGCCAACACCATGCAGGACAAAGCGATGA GATACGATCTACCGCTCGAGAGCAGGTGTGACGGAT SEQ ID NO. 190 EcO-60B R - ATCCGTCACACCTGCTCTCGAGCGGTAGATCGTATCT CATCGCTTTGTCCTGCATGGTGTTGGCTCCCGTAT SEQ ID NO. 191 EcO-62 F - ATACGGGAGCCAACACCATGGAGAGGAAGACGGAAA GTATGGAGTGGATGAAGGAGAGCAGGTGTGACGGAT SEQ ID NO. 192 EcO-62 R - ATCCGTCACACCTGCTCTCCTTCATCCACTCCATACTTT CCGTCTTCCTCTCCATGGTGTTGGCTCCCGTAT SEQ ID NO. 193 EcO-63 F - ATACGGGAGCCAACACCACGAAGGAGTAAAGCATGCT GTCCCTATGAGCTGGGAAGAGCAGGTGTGACGGAT SEQ ID NO. 194 EcO-63 R - ATCCGTCACACCTGCTCTTCCCAGCTCATAGGGACAGC ATGCTTTACTCCTTCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 195 EcO-64 F - ATACGGGAGCCAACACCACCCTGAGACATACCTAGTCA AGTGGAACAGACAGGTAGAGCAGGTGTGACGGAT SEQ ID NO. 196 EcO-64 R - ATCCGTCACACCTGCTCTACCTGTCTGTTCCACTTGACT AGGTATGTCTCAGGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 197 EcO-65 F - ATACGGGAGCCAACACCAGTAGGGAGAAGTTCGAATG AAAATACGCTACGAACAAGAGCAGGTGTGACGGAT SEQ ID NO. 198 EcO-65 R - ATCCGTCACACCTGCTCTTGTTCGTAGCGTATTTTCATT CGAACTTCTCCCTACTGGTGTTGGCTCCCGTAT SEQ ID NO. 199 EcO-66 F - ATACGGGAGCCAACACCACTCCCTACCGGCTCTGCGGG AAATATGTTTTGACCCAGAGCAGGTGTGACGGAT SEQ ID NO. 200 EcO-66 R - ATCCGTCACACCTGCTCTGGGTCAAAACATATTTCCCG CAGAGCCGGTAGGGAGTGGTGTTGGCTCCCGTAT SEQ ID NO. 201 EcO-67 F - ATACGGGAGCCAACACCACCCGTGGCCTTCACCCAGCC AGGGGCCCCGTCTCTGAGAGCAGGTGTGACGGAT SEQ ID NO. 202 EcO-67 R - ATCCGTCACACCTGCTCTCAGAGACGGGGCCCCTGGCT GGGTGAAGGCCACGGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 203 EcO-68 F - ATACGGGAGCCAACACCACAAAGTCCTCCCCCCTGGGC GCCTTCACCCCACTGCAGAGCAGGTGTGACGGAT SEQ ID NO. 204 EcO-68 R - ATCCGTCACACCTGCTCTGCGGTGGGGTGAAGGCGCCC AGGGGGGAGGACTTTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 205 EcO-69 R - ATACGGGAGCCAACACCATGGTAGACAGCGTCGCCCT GCCATCACTCCGGCCCCAGAGCAGGTGTGACGGAT SEQ ID NO. 206 EcO-69 F - ATCCGTCACACCTGCTCTGGGGCCGGAGTGATGGCAGG GCGACGCTGTCTACCATGGTGTTGGCTCCCGTAT SEQ ID NO. 207 EcO-70 F - ATACGGGAGCCAACACCACGATCCCGGCGCGACGGAT GTAAAATAAGTGTGCTCAGAGCAGGTGTGACGGAT SEQ ID NO. 208 EcO-70 R - ATCCGTCACACCTGCTCTGAGCACACTTATTTTACATCC GTCGCGCCGGGATCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 209 EcO-71 F - ATACGGGAGCCAACACCAGGGAAGATATGCAACAGAT GGTGGACCGTAGTATGGAGAGCAGGTGTGACGGAT SEQ ID NO. 210 EcO-71 R - ATCCGTCACACCTGCTCTCCATACTACGGTCCACCATCT GTTGCATATCTTCCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 211 EcO-72 F - ATACGGGAGCCAACACCACAGCAGGGTACTGTAGTGG TGGGGGGCCGGTCCGGGAGAGCAGGTGTGACGGAT SEQ ID NO. 212 EcO-72 R - ATCCGTCACACCTGCTCTCCCGGACCGGCCCCCCACCA CTACAGTACCCTGCTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 213 EcO-73 F - ATACGGGAGCCAACACCAAGACGGACAGGGGACGTCG GTGAAGCGACGGATTGGAGAGCAGGTGTGACGGAT SEQ ID NO. 214 EcO-73 R - ATCCGTCACACCTGCTCTCCAATCCGTCGCTTCACCGA CGTCCCCTGTCCGTCTTGGTGTTGGCTCCCGTAT SEQ ID NO. 215 EcO-74 F - ATACGGGAGCCAACACCACACGAGCCAGGTAAAAGTA AGCCACACAAAGTGCTCAGAGCAGGTGTGACGGAT SEQ ID NO. 216 EcO-74 R - ATCCGTCACACCTGCTCTGAGCACTTTGTGTGGCTTACT TTTACCTGGCTCGTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 217 EcO-75 F - ATACGGGAGCCAACACCACCACGCGACACCCCCTCCT GTCCCCCGCCCGCTTCCAGAGCAGGTGTGACGGAT SEQ ID NO. 218 EcO-75 R - ATCCGTCACACCTGCTCTGGAAGCGGGCGGGGGACAG GAGGGGGTGTCGCGTGGTGGTGTTGGCTCCCGTAT Aged E. coli (AEc; Greater than one month at 4.degree. C.) SEQ ID NO. 219 AEc-47F - ATACGGGAGCCAACACCATCGAGAAGCATTGATAACAA AATTTAAACCCCTGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 220 AEc-47R - ATCCGTCACACCTGCTCTGGCAGGGGTTTAAATTTTGTT ATCAATGCTTCTCGATGGTGTTGGCTCCCGTAT SEQ ID NO. 221 AEc-48 F - ATACGGGAGCCAACACCATCGAGAAGCATTGATAACA AAATTTAAACCCCTGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 222 AEc-48R - ATCCGTCACACCTGCTCTGGCAGGGGTTTAAATTTTGTT ATCAATGCTTCTCGATGGTGTTGGCTCCCGTAT SEQ ID NO. 223 AEc-49 F - ATACGGGAGCCAACACCAGGATCCGTAGAATGATTTA AATAAACACGAACACATAGAGCAGGTGTGACGGAT SEQ ID NO. 224 AEc-49R - ATCCGTCACACCTGCTCTATGTGTTCGTGTTTATTTAAA TCATTCTACGGATCCTGGTGTTGGCTCCCGTAT LPS Core Antigen DNA ligands SEQ ID NO. 225 (Glucosamine(G)1F) - ATCCGTCACACCTGCTCTAATTAGGATACG GGGCAACAGAACGAGAGGGGGGAATGGTGTTGGCTCCCGTAT SEQ ID NO. 226 (G2F) - ATCCGTCACACCTGCTCTCGGACCAGGTCAGACAAGCACAT CGGATATCCGGCTGGTGTTGGCTCCCGTAT SEQ ID NO. 227 (G5F) - ATCCGTCACACCTGCTCTTGAGTCAAAGAGTTTAGGGAGGA GCTAACATAACAGTGGTGTTGGCTCCCGTAT SEQ ID NO. 228 (G7F) - ATCCGTCACACCTGCTCTAACAACAATGCATCAGCGGGCTG GGAACGCATGCGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 229 (G8F) - ATCCGTCACACCTGCTCTGAACAGGTTATAAGCAGGAGTGA TAGTTTCAGGATCTGGTGTTGGCTCCCGTAT SEQ ID NO. 230 (G9F) - ATCCGTCACACCTGCTCTCGGCGGCTCGCAAACCGAGTGGT CAGCACCCGGGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 231 (G10F) - ATCCGTCACACCTGCTCTGCGCAAGACGTAATCCACAAGA CCGTGAAAACATAGTGGTGTTGGCTCCCGTAT SEQ ID NO. 232 (G1R) - ATACGGGAGCCAACACCATTCCCCCCTCTCGTTCTGTTGCC CCGTATCCTAATTAGAGCAGGTGTGACGGAT SEQ ID NO. 233 (G2R) - ATACGGGAGCCAACACCAGCCGGATATCCGATGTGCTTGTC TGACCTGGTCCGAGAGCAGGTGTGACGGAT SEQ ID NO. 234 (G5R) - ATACGGGAGCCAACACCACTGTTATGTTAGCTCCTCCCTAA ACTCTTTGACTCAAGAGCAGGTGTGACGGAT SEQ ID NO. 235 (G7R) - ATACGGGAGCCAACACCACCGCATGCGTTCCCAGCCCGCTG ATGCATTGTTGTTAGAGCAGGTGTGACGGAT SEQ ID NO. 236 (G8R) - ATACGGGAGCCAACACCAGATCCTGAAACTATCACTCCTG CTTATAACCTGTTCAGAGCAGGTGTGACGGAT SEQ ID NO. 237 (G9R) - ATACGGGAGCCAACACCAACCCGGGTGCTGACCACTCGGT TTGCGAGCCGCCGAGAGCAGGTGTGACGGAT SEQ ID NO. 238 (G10R) - ATACGGGAGCCAACACCACTATGTTTTCACGGTCTTGTGG ATTACGTCTTGCGCAGAGCAGGTGTGACGGAT SEQ ID NO. 239 (KDO (K) Antigen 2F) - ATCCGTCACACCTGCTCTAGGCGTAGTG ACTAAGTCGCGCGAAAATCACAGCATTGGTGTTGGCTCCCGTAT SEQ ID NO. 240 (K5F) - ATCCGTCACACCTGCTCTCAGCGGCAGCTATACAGTGAGAA CGGACTAGTGCGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 241 (K7F) - ATCCGTCACACCTGCTCTGGCAAATAATACTAGCGATGATG GATCTGGATAGACTGGTGTTGGCTCCCGTAT SEQ ID NO. 242 (K8F) - ATCCGTCACACCTGCTCTGGGGGTGCGACTTAGGGTAAGTG GGAAAGACGATGCTGGTGTTGGCTCCCGTAT SEQ ID NO. 243 (K9F) - ATCCGTCACACCTGCTCTCAAGAGGAGATGAACCAATCTTA GTCCGACAGGCGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 244 (K10F) - ATCCGTCACACCTGCTCTGGCCCGGAATTGTCATGACGTC ACCTACACCTCCTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 245 (K2R) - ATACGGGAGCCAACACCAATGCTGTGATTTTCGCGCGACTT AGTCACTACGCCTAGAGCAGGTGTGACGGAT SEQ ID NO. 246 (K5R) - ATACGGGAGCCAACACCAACGCACTAGTCCGTTCTCACTGT ATAGCTGCCGCTGAGAGCAGGTGTGACGGAT SEQ ID NO. 247 (K7R) - ATACGGGAGCCAACACCAGTCTATCCAGATCCATCATCGC TAGTATTATTTGCCAGAGCAGGTGTGACGGAT

SEQ ID NO. 248 (K8R) - ATACGGGAGCCAACACCAGCATCGTCTTTCCCACTTACCCT AAGTCGCACCCCCAGAGCAGGTGTGACGGAT SEQ ID NO. 249 (K9R) - ATACGGGAGCCAACACCACCGCCTGTCGGACTAAGATTGG TTCATCTCCTCTTGAGAGCAGGTGTGACGGAT SEQ ID NO. 250 (K10R) - ATACGGGAGCCAACACCACAGGAGGTGTAGGTGACGTCA TGACAATTCCGGGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 251 (Whole LPS from E. coli O111:B4 (L)1F) - ATCCGTCAC CCCTGCTCTCGTCGCTATGAAGTAACAAAGATAGGAGCAATCGGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 252 (L3F) - ATCCGTCACACCTGCTCTAACGAAGACTGAAACCAAAGCAG TGACAGTGCTGAATGGTGTTGGCTCCCGTAT SEQ ID NO. 253 (L4F) - ATCCGTCACACCTGCTCTCGGTGACAATAGCTCGATCAGCC C AAAGTCGTCAGATGGTGTTGGCTCCCGTAT SEQ ID NO. 254 (L6F) - ATCCGTCACACCTGCTCTAACGAAATAGACCACAAATCGAT ACTTTATGTTATTGGTGTTGGCTCCCGTAT (71) SEQ ID NO. 255 (L7F) - ATCCGTCACACCTGCTCTGTCGAATGCTCTGCCTGGAAGAG TTGTTAGCAGGGATGGTGTTGGCTCCCGTAT SEQ ID NO. 256 (L8F) - ATCCGTCACACCTGCTCTTAAGCCGAGGGGTAAATCTAGGA CAGGGGTCCATGATGGTGTTGGCTCCCGTAT SEQ ID NO. 256 (L9F) - ATCCGTCACACCTGCTCTACTGGCCGGCTCAGCATGACTAA GAAGGAAGTTATGTGGTGTTGGCTCCCGTAT SEQ ID NO. 258 (L10F) - ATCCGTCACACCTGCTCTGGTACGAATCACAGGGGATGCT GGAAGCTTGGCTCTTGGTGTTGGCTCCCGTAT SEQ ID NO. 259 (L1R) - ATACGGGAGCCAACACCACCCGATTGCTCCTATCTTTGTTA CTTCATAGCGACGAGAGCAGGGGTGACGGAT SEQ ID NO. 260 (L3R) - ATACGGGAGCCAACACCATTCAGCACTGTCACTGCTTTGGT TTCAGTCTTCGTTAGAGCAGGTGTGACGGAT SEQ ID NO. 261 (L4R) - ATACGGGAGCCAACACCATCTGACGACTTTGGGCTGATCGA GCTATTGTCACCGAGAGCAGGTGTGACGGAT SEQ ID NO. 262 (L6R) - ATACGGGAGCCAACACCAATAACATAAAGTATCGATTTGTG GTCTATTTCGTTAGAGCAGGTGTGACGGAT SEQ ID NO. 263 (L7R) - ATACGGGAGCCAACACCATCCCTGCTAACAACTCTTCCAGG CAGAGCATTCGACAGAGCAGGTGTGACGGAT SEQ ID NO. 264 (L8R) - ATACGGGAGCCAACACCATCATGGACCCCTGTCCTAGATTT ACCCCTCGGCTTAAGAGCAGGTGTGACGGAT SEQ ID NO. 265 (L9R) - ATACGGGAGCCAACACCACATAACTTCCTTCTTAGTCATGC TGAGCCGGCCAGTAGAGCAGGTGTGACGGAT SEQ ID NO. 266 (L10R) - ATACGGGAGCCAACACCAAGAGCCAAGCTTCCAGCATCCC CTGTGATTCGTACCAGAGCAGGTGTGACGGAT SEQ ID NO. 267 (Rough (Ra or R) Core LPS Antigens R1F) - ATCCGTC ACACCTGCTCTCCGCACGTAGGACCACTTTGGTACACGCTCCCGTAGTGGTGTTGGCTCCCGTAT SEQ ID NO. 268 (R5F) - ATCCGTCACACCTGCTCTACGGATGAACGAAGATTTTAAAG TCAAGCTAATGCATGGTGTTGGCTCCCGTAT SEQ ID NO. 269 (R6F) - ATCCGTCACACCTGCTCTGTAGTGAAGAGTCCGCAGTCCAC GCTGTTCAACTCATGGTGTTGGCTCCCGTAT SEQ ID NO. 270 (R7F) - ATCCGTCACACCTGCTCTACCGGCTGGCACGGTTATGTGTGA CGGGCGAAGATATGGTGTTGGCTCCCGTAT SEQ ID NO. 271 (R9F) - ATCCGTCACACCTGCTCTGCGTGTGGAGCGCCTAGGTGAGT GGTGTTGGCTCCCGTAT SEQ ID NO. 272 (R10F) - ATCCGTCACACCTGCTCTGATGTCCCTTTGAAGAGTTCCAT GACGCTGGCTCCTTGGTGTTGGCTCCCGTAT SEQ ID NO. 273 (R1R) - ATACGGGAGCCAACACCACTACGGGAGCGTGTACCAAAGT GGTCCTACGTGCGGAGAGCAGGTGTGACGGAT SEQ ID NO. 274 (R5R) - ATACGGGAGCCAACACCATGCATTAGCTTGACTTTAAAATC TTCGTTCATCCGTAGAGCAGGTGTGACGGAT SEQ ID NO. 275 (R6R) - ATACGGGAGCCAACACCATGAGTTGAACAGCGTGGACTGC GGACTCTTCACTACAGAGCAGGTGTGACGGAT SEQ ID NO. 276 (R7R) - ATACGGGAGCCAACACCATATCTTCGCCCGTCACACATAAC CGTGCCAGCCGGTAGAGCAGGTGTGACGGAT SEQ ID NO. 277 (R9R) - ATACGGGAGCCAACACCACTCACCTAGGCGCTCCACACGC AGAGCAGGTGTGACGGAT SEQ ID NO. 278 (R10R) - ATACGGGAGCCAACACCAAGGAGCCAGCGTCATGGAACTC TTCAAAGGGACATCAGAGCAGGTGTGACGGAT Listeriolysin (A surface protein on Listeria monocytogenes) DNA ligands SEQ ID NO. 279 (LO-10F) - ATCCGTCACACCTGCTCTGCCGGACCATCCAATATCAGC TGTGGTGTTGGCTCCCGTAT SEQ ID NO. 280 (LO-11F) - ATCCGTCACACCTGCTCTGGTGGAATGGACTAAGCTAGC TAGCGTTTTAAAAGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 281 (LO-13F) - ATCCGTCACACCTGCTCTTAAAGTAGAGGCTGTTCTCCA GACGTCGCAGGAGGATGGTGTTGGCTCCCGTAT SEQ ID NO. 282 (LO-15F) - ATCCGTCACACCTGCTCTGTAGATGGCAAGGCATAAGCG TCCGGAACGATAGAATGGTGTTGGCTCCCGTAT SEQ ID NO. 283 (LO-16F) - ATCCGTCACACCTGCTCTGTAGATGGCAAGGCATAAGCG TCCGGAACGATAGAATGGTGTTGGCTCCCGTAT SEQ ID NO. 284 (LO-17F) - ATACGGGAGCCAACACCACAGCTGATATTGGATGGTCC GGCAGAGCAGGTGTGACGGAT SEQ ID NO. 285 (LO-19F) - ATCCGTCACACCTGCTCTTGGGCAGGAGCGAGAGACTCT AATGGTAAGCAAGAATGGTGTTGGCTCCCGTAT SEQ ID NO. 286 (LO-20F) - ATCCGTCACACCTGCTCTCCAACAAGGCGACCGACCGCA TGCAGATAGCCAGGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 287 (LO-10R) - ATACGGGAGCCAACACCACAGCTGATATTGGATGGTCC GGCAGAGCAGGTGTGACGGAT SEQ ID NO. 288 (LO-11R) - ATACGGGAGCCAACACCACCTTTTAAAACGCTAGCTAG CTTAGTCCATTCCACCAGAGCAGGTGTGACGGAT SEQ ID NO. 289 (LO-13R) - ATACGGGAGCCAACACCATCCTCCTGCGACGTCTGGAGA ACAGCCTCTACTTTAAGAGCAGGTGTGACGGAT SEQ ID NO. 290 (LO-15R) - ATACGGGAGCCAACACCATTCTATCGTTCCGGACGCTTA TGCCTTGCCATCTACAGAGCAGGTGTGACGGAT SEQ ID NO. 291 (LO-16R) - ATACGGGAGCCAACACCATTCTATCGTTCCGGACGCTTA TGCCTTGCCATCTACAGAGCAGGTGTGACGGAT SEQ ID NO. 292 (LO-17R) - ATCCGTCACACCTGCTCTGCCGGACCATCCAATATCAGC TGTGGTGTTGGCTCCCGTAT SEQ ID NO. 293 (LO-19R) - ATACGGGAGCCAACACCATTCTTGCTTACCATTAGAGTC TCTCGCTCCTGCCCAAGAGCAGGTGTGACGGAT SEQ ID NO. 294 (LO-20R) - ATACGGGAGCCAACACCAACCTGGCTATCTGCATGCGGT CGGTCGCCTTGTTGGAGAGCAGGTGTGACGGAT Listeriolysin (Alternate form of Listeria surface protein designated "Pest-Free") DNA ligands SEQ ID NO. 295 (LP-3F) - ATCCGTCACACCTGCTCTGTAGATGGCAAGGCATAAGCGT CCGGAACGATAGAATGGTGTTGGCTCCCGTAT SEQ ID NO. 296 (LP-11F) - ATCCGTCACACCTGCTCTAACCAAAAGGGTAGGAGACCA AGCTAGCGATTTGGATGGTGTTGGCTCCCGTAT SEQ ID NO. 297 (LP-13F) - ATCCGTCACACCTGCTCTGCCGGACCATCCAATATCAGCT GTGGTGTTGGCTCCCGTAT SEQ ID NO. 298 (LP-14F) - ATCCGTCACACCTGCTCTGAAGCCTAACGGAGAAGATGG CCCTACTGCCGTAGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 299 (LP-15F) - ATCCGTCACACCTGCTCTACTAAACAAGGGCAAACTGTA AACACAGTAGGGGCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 300 (LP-17F) - ATCCGTCACACCTGCTCTGGTGTTGGCTCCCGTATAGCTT GGCTCCCGTATGGTGTTGGCTCCCGTAT SEQ ID NO. 301 (LP-18F) - TCCGTCACACCTGCTCTGTCGCGATGATGAGCAGCAGCG CAGGAGGGAGGGGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 302 (LP-20F) - ATCCGTCACACCTGCTCTGATCAGGGAAGACGCCAACAC TGGTGTTGGCTCCCGTAT SEQ ID NO. 303 (LP-3R) - ATACGGGAGCCAACACCATTCTATCGTTCCGGACGCTTA TGCCTTGCCATCTACAGAGCAGGTGTGACGGAT SEQ ID NO. 304 (LP-11R) - ATACGGGAGCCAACACCATCCAAATCGCTAGCTTGGTC TCCTACCCTTTTGGTTAGAGCAGGTGTGACGGAT SEQ ID NO. 305 (LP-13R) - ATACGGGAGCCAACACCACAGCTGATATTGGATGGTCCG GCAGAGCAGGTGTGACGGAT SEQ ID NO. 306 (LP-14R) - ATACGGGAGCCAACACCACCTACGGCAGTAGGGCCATC TTCTCCGTTAGGCTTCAGAGCAGGTGTGACGGAT SEQ ID NO. 307 (LP-15R) - ATACGGGAGCCAACACCACGCCCCTACTGTGTTTACAG TTTGCCCTTGTTTAGTAGAGCAGGTGTGACGGAT SEQ ID NO. 308 (LP-17R) - ATACGGGAGCCAACACCATACGGGAGCCAAGCTATACG GGAGCCAACACCAGAGCAGGTGTGACGGAT SEQ ID NO. 309 (LP-18R) - ATACGGGAGCCAACACCACCCCCTCCCTCCTGCGCTGCT GCTCATCATCGCGACAGAGCAGGTGTGACGGAT SEQ ID NO. 310 (LP-20R) - ATACGGGAGCCAACACCAGTGTTGGCGTCTTCCCTGATC AGAGCAGGTGTGACGGAT Listeria monocytogenes Whole Cell (LmW) SEQ ID NO. 311 LmW-2 F - ATACGGGAGCCAACACCAATACCTGTAAAAGTCTGAG AAGTGGAGTAACCTAGAGAGCAGGTGTGACGGAT (71) SEQ ID NO. 312 LmW-2 R - ATCCGTCACACCTGCTCTCTAGGTTACTCCACTTCTCA GACTTTTACAGGTATTGGTGTTGGCTCCCGTAT (71) SEQ ID NO. 313 LmW-3 F - ATACGGGAGCCAACACCACCGACCAACAGTAATAGCC TAAAAGAGTTATGCGCTAGAGCAGGTGTGACGGAT SEQ ID NO. 314 LmW-3 R - ATCCGTCACACCTGCTCTAGCGCATAACTCTTTTAGGCT ATTACTGTTGGTCGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 315 LmW-5 F - ATACGGGAGCCAACACCAGGTGGACTATATATGAAGTT AGTGAGCTTTAACAGGAGAGCAGGTGTGACGGAT SEQ ID NO. 316 LmW-5 R - ATCCGTCACACCTGCTCTCCTGTTAAAGCTCACTAACT TCATATATAGTCCACCTGGTGTTGGCTCCCGTAT SEQ ID NO. 317 LmW-8 F - ATACGGGAGCCAACACCACAGGAGAGGCAGTAAAAG GGTTGGCTGCCTGGGTAGAGAGCAGGTGTGACGGAT SEQ ID NO. 318 LmW-8 R - ATCCGTCACACCTGCTCTCTACCCAGGCAGCCAACCCT TTTACTGCCTCTCCTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 319 LmW-9 F - ATACGGGAGCCAACACCATTAGCAAGGTAAGAACAGT TTTAATACATGCCTTCCAGAGCAGGTGTGACGGAT SEQ ID NO. 320 LmW-9 R - ATCCGTCACACCTGCTCTGGAAGGCATGTATTAAAACT GTTCTTACCTTGCTAATGGTGTTGGCTCCCGTAT SEQ ID NO. 321 LmW-10 F - ATACGGGAGCCAACACCATAACAAATAACCACCCTC AATGCTAGATAGTGGCTTAGAGCAGGTGTGACGGAT SEQ ID NO. 322 LmW-10 R - ATCCGTCACACCTGCTCTAAGCCACTATCTAGCATTGA GGGTGGTTATTTGTTATGGTGTTGGCTCCCGTAT SEQ ID NO. 323 LmW-11 F - ATACGGGAGCCAACACCAGGAACATGATAAGTGAGA AGTGCGACGTTAGCTTATAGAGCAGGTGTGACGGAT SEQ ID NO. 324 LmW-11 R - ATCCGTCACACCTGCTCTATAAGCTAACGTCGCACTTC TCACTTATCATGTTCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 325 LmW-12 F - ATACGGGAGCCAACACCAAAAGGGTGTTCATACGGA ATGTAGATCGCCTAAGTGAGAGCAGGTGTGACGGAT SEQ ID NO. 326 LmW-12 R - ATCCGTCACACCTGCTCTCACTTAGGCGATCTACATTC CGTATGAACACCCTTTTGGTGTTGGCTCCCGTAT SEQ ID NO. 327 LmW-13 F - ATACGGGAGCCAACACCATGAGCACCGGCAAACGCG TAGGTTAAGCTACATGACAGAGCAGGTGTGACGGAT SEQ ID NO. 328 LmW-13 R - ATCCGTCACACCTGCTCTGTCATGTAGCTTAACCTACG CGTTTGCCGGTGCTCATGGTGTTGGCTCCCGTAT SEQ ID NO. 329 LmW-14 F - ATACGGGAGCCAACACCATGATTAGATACTGCCTAGC TGTGTGCTCGTTGGGGGAGAGCAGGTGTGACGGAT

SEQ ID NO. 330 LmW-14 R - ATCCGTCACACCTGCTCTCCCCCAACGAGCACACAGC TAGGCAGTATCTAATCATGGTGTTGGCTCCCGTAT SEQ ID NO. 331 LmW-19 F - ATACGGGAGCCAACACCAGGAGGAAGGTCAGCGTTC TTCACGTGGCTAGGGGGCAGAGCAGGTGTGACGGAT SEQ ID NO. 332 LmW-19 R - ATCCGTCACACCTGCTCTGCCCCCTAGCCACGTGAAG AACGCTGACCTTCCTCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 333 LmW-22 F - ATACGGGAGCCAACACCAACTGAGCTATATCTAGATC GACTTACACATACACGTAGAGCAGGTGTGACGGAT SEQ ID NO. 334 LmW-22 R - ATCCGTCACACCTGCTCTACGTGTATGTGTAAGTCGAT CTAGATATAGCTCAGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 335 LmW-23 F - ATACGGGAGCCAACACCAGAGACGTGTGAAGTCCAG G CAGGGTGCCTTCTGTCGAGAGCAGGTGTGACGGAT SEQ ID NO. 336 LmW-23 R - ATCCGTCACACCTGCTCTCGACAGAAGGCACCCTGCC TGGACTTCACACGTCTCTGGTGTTGGCTCCCGTAT SEQ ID NO. 337 LmW-24 F - ATACGGGAGCCAACACCATCAAGTGGTGAGCGCCTCG TCGGGAACTGCCGTGCGAGAGCAGGTGTGACGGAT SEQ ID NO. 338 LmW-24 R - ATCCGTCACACCTGCTCTCGCACGGCAGTTCCCGACG AGGCGCTCACCACTTGATGGTGTTGGCTCCCGTAT SEQ ID NO. 339 LmW-25 F - ATACGGGAGCCAACACCACCGCTGAAACCTCTCCGCC GTCCCGCCCTCCTCCCCAGAGCAGGTGTGACGGAT SEQ ID NO. 340 LmW-25 R - ATCCGTCACACCTGCTCTGGGGAGGAGGGCGGGACGG CGGAGAGGTTTCAGCGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 341 LmW-27 F - ATACGGGAGCCAACACCAGGAGATGGTAGCACTAAA ATACGACGTATGCTGTGTAGAGCAGGTGTGACGGAT SEQ ID NO. 342 LmW-27 R - ATCCGTCACACCTGCTCTACACAGCATACGTCGTATTT TAGTGCTACCATCTCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 343 LmW-28 F - ATACGGGAGCCAACACCAAATCGACCGGACTAATCCT GTGACTCCCCTATGTCTAGAGCAGGTGTGACGGAT SEQ ID NO. 344 LmW-28 R - ATCCGTCACACCTGCTCTAGACATAGGGGAGTCACAG G ATTAGTCCGGTCGATTTGGTGTTGGCTCCCGTAT SEQ ID NO. 345 LmW-30 F - ATACGGGAGCCAACACCAAATTCAATTGCGCACGTAA GAATAGATAGGCTGACCAGAGCAGGTGTGACGGAT SEQ ID NO. 346 LmW-30 R - ATCCGTCACACCTGCTCTGGTCAGCCTATCTATTCTTA CGTGCGCAATTGAATTTGGTGTTGGCTCCCGTAT SEQ ID NO. 347 LmW-31 F - ATACGGGAGCCAACACCACACACAGAGCGCCATGGA CTCAGTCAGATGTGATGTAGAGCAGGTGTGACGGAT SEQ ID NO. 348 LmW-31 R - ATCCGTCACACCTGCTCTACATCACATCTGACTGAGT CCATGGCGCTCTGTGTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 349 LmW-32 F - ATACGGGAGCCAACACCATCCAATGAGGCCATGGACC GGTAAACTCGGACGCGCAGAGCAGGTGTGACGGAT SEQ ID NO. 350 LmW-32 R - ATCCGTCACACCTGCTCTGCGCGTCCGAGTTTACCGGT CCATGGCCTCATTGGATGGTGTTGGCTCCCGTAT SEQ ID NO. 351 LmW-33 F - ATACGGGAGCCAACACCAACCCCGGTACCATCCGAC ACCACGAGCACCCGGACGAGAGCAGGTGTGACGGAT SEQ ID NO. 352 LmW-33 R - ATCCGTCACACCTGCTCTCGTCCGGGTGCTCGTGGTGT CGGATGGTACCGGGGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 353 LmW-34 F - ATACGGGAGCCAACACCAAGGCGAAACTATTCACAG AGACTGATCCAGCAAGGTAGAGCAGGTGTGACGGAT SEQ ID NO. 354 LmW-34 R - ATCCGTCACACCTGCTCTACCTTGCTGGATCAGTCTCT GTGAATAGTTTCGCCTTGGTGTTGGCTCCCGTAT SEQ ID NO. 355 LmW-35 F - ATACGGGAGCCAACACCAAACACATAGTCGTGGCAG AACGAATACTTAGCGCGGAGAGCAGGTGTGACGGAT SEQ ID NO. 356 LmW-35 R - ATCCGTCACACCTGCTCTCCGCGCTAAGTATTCGTTCT GCCACGACTATGTGTTTGGTGTTGGCTCCCGTAT SEQ ID NO. 357 LmW-36 F - ATACGGGAGCCAACACCAACACGATCGACGGCGCTT GGTCCCTTACAACCCTGCAGAGCAGGTGTGACGGAT SEQ ID NO. 358 LmW-36 R - ATCCGTCACACCTGCTCTGCAGGGTTGTAAGGGACCA AGCGCCGTCGATCGTGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 359 LmW-37 F - ATACGGGAGCCAACACCAAACCAGGACTCTGTCGCTC TAAACATGACCATCGATAGAGCAGGTGTGACGGAT SEQ ID NO. 360 LmW-37 R - ATCCGTCACACCTGCTCTATCGATGGTCATGTTTAGA GCGACAGAGTCCTGGTTTGGTGTTGGCTCCCGTAT SEQ ID NO. 361 LmW-39 F - ATACGGGAGCCAACACCACAACCACTGTAGGCTCAT GTAACTACCCGTTGTTGAGAGCAGGTGTGACGGAT (71) SEQ ID NO. 362 LmW-39 R - ATCCGTCACACCTGCTCTCAACAACGGGTAGTTACAT GAGCCTACAGTGGTTGTGGTGTTGGCTCCCGTAT (71) SEQ ID NO. 363 LmW-40 F - ATACGGGAGCCAACACCAGGGGACAAGCAGAACCGA ACAGATTGCAACGTATCCAGAGCAGGTGTGACGGAT SEQ ID NO. 364 LmW-40 R - ATCCGTCACACCTGCTCTGGATACGTTGCAATCTGTTC GGTTCTGCTTGTCCCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 365 LmW-41 F - ATACGGGAGCCAACACCAGCGCTTGAACAACATAAT GCCGCCCAAGACCTTGACAGAGCAGGTGTGACGGAT SEQ ID NO. 366 LmW-41 R - ATCCGTCACACCTGCTCTGTCAAGGTCTTGGGCGGCA TTATGTTGTTCAAGCGCTGGTGTTGGCTCCCGTAT SEQ ID NO. 367 LmW-42 F - ATACGGGAGCCAACACCACAGTGCCTAGACTTTTACA ATGAACCAATTGCTGGAAGAGCAGGTGTGACGGAT SEQ ID NO. 368 LmW-42 R - ATCCGTCACACCTGCTCTTCCAGCAATTGGTTCATTGT AAAAGTCTAGGCACTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 369 LmW-43 F - ATACGGGAGCCAACACCACCCACTCTCCCCCCGCTCC CGCTCCCCCGCTCCGCGAGAGCAGGTGTGACGGAT SEQ ID NO. 370 LmW-43 R - ATCCGTCACACCTGCTCTCGCGGAGCGGGGGAGCGGG AGCGGGGGGAGAGTGGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 371 LmW-44 F - ATACGGGAGCCAACACCATCTAACAATCATACACTTG GAAGGTGACTGTCCTGGAGAGCAGGTGTGACGGAT SEQ ID NO. 372 LmW-44 R - ATCCGTCACACCTGCTCTCCAGGACAGTCACCTTCCA AGTGTATGATTGTTAGATGGTGTTGGCTCCCGTAT SEQ ID NO. 373 LmW-46 F - ATACGGGAGCCAACACCATGTCAGGACCTCCATCGCC CGGGCCCGCCGCCGCTGAGAGCAGGTGTGACGGAT SEQ ID NO. 374 LmW-46 R - ATCCGTCACACCTGCTCTCAGCGGCGGCGGGCCCGGG CGATGGAGGTCCTGACATGGTGTTGGCTCCCGTAT SEQ ID NO. 375 LmW-47 F - ATACGGGAGCCAACACCAGGCGACAGCCTGTGCGAGT AAGATTGAATGGTAGGTAGAGCAGGTGTGACGGAT SEQ ID NO. 376 LmW-47 R - ATCCGTCACACCTGCTCTACCTACCATTCAATCTTACT CGCACAGGCTGTCGCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 377 LmW-49 F - ATACGGGAGCCAACACCATCTGTGTCAGTCTGGCCTG TTTTTTATTCTCCGCGGAGAGCAGGTGTGACGGAT SEQ ID NO. 378 LmW-49 R - ATCCGTCACACCTGCTCTCCGCGGAGAATAAAAAACA GGCCAGACTGACACAGATGGTGTTGGCTCCCGTAT SEQ ID NO. 379 LmW-50 F - ATACGGGAGCCAACACCAGCCAGGAAAACTATGAGG CAAAAACACGATCCGGGTAGAGCAGGTGTGACGGAT SEQ ID NO. 380 LmW-50 R - ATCCGTCACACCTGCTCTACCCGGATCGTGTTTTTGCC TCATAGTTTTCCTGGCTGGTGTTGGCTCCCGTAT N-acetyl-glucosamine (NAG) Component of Bacterial Peptidoglycan and Fungal Chitin SEQ ID NO. 381 NAG 13F - ATACGGGAGCCAACACCATAGAAGTATGTTGTTATTCTA TGGAAATAAAACGACAGAGCAGGTGTGACGGAT SEQ ID NO. 382 NAG 13R - ATCCGTCACACCTGCTCTGTCGTTTTATTTCCATAGAATA ACAACATACTTCTATGGTGTTGGCTCCCGTAT SEQ ID NO. 383 NAG 14F - ATACGGGAGCCAACACCATCCCGTTGTGATCAGAGAGC ATGAAATGATGTTTTGAGAGCAGGTGTGACGGAT SEQ ID NO. 384 NAG 14R - ATCCGTCACACCTGCTCTCAAAACATCATTTCATGCTCT CTGATCACAACGGGATGGTGTTGGCTCCCGTAT SEQ ID NO. 385 NAG 18F - ATACGGGAGCCAACACCATGCATGGGACCTGTTATCCTA ACAAGCTGTCAAGGCAGAGCAGGTGTGACGGAT SEQ ID NO. 386 NAG 18R - ATCCGTCACACCTGCTCTGCCTTGACAGCTTGTTAGGAT AACAGGTCCCATGCATGGTGTTGGCTCCCGTAT SEQ ID NO. 387 NAG 20F - ATACGGGAGCCAACACCACAAAACGTTCCGAGGGAGTA AGCACTTAATAATGTAGAGCAGGTGTGACGGAT (71) SEQ ID NO. 388 NAG 20R - ATCCGTCACACCTGCTCTACATTATTAAGTGCTTACTCCC TCGGAACGTTTTGTGGTGTTGGCTCCCGTAT (71) SEQ ID NO. 389 NAG 21F - ATACGGGAGCCAACACCACGTCTTATAGATGTCTGTATT GTTTATCGCTCGCCCAGAGCAGGTGTGACGGAT SEQ ID NO. 390 NAG 21R - ATCCGTCACACCTGCTCTGGGCGAGCGATAAACAATACA GACATCTATAAGACGTGGTGTTGGCTCCCGTAT SEQ ID NO. 391 NAG 22F - ATACGGGAGCCAACACCACCATCTCTGGTGATAACCAGT GATCTTAACTATAGCAGAGCAGGTGTGACGGAT SEQ ID NO. 392 NAG 22R - ATCCGTCACACCTGCTCTGCTATAGTTAAGATCACTGGT TATCACCAGAGATGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 393 NAG 23F - ATACGGGAGCCAACACCACCACCTCACTACAGTGATCTT TTGCTCTGAATAGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 394 NAG 23R - ATCCGTCACACCTGCTCTGGCTATTCAGAGCAAAAGATC ACTGTAGTGAGGTGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 395 NAG 25F - ATACGGGAGCCAACACCATGTCTCTTAGGATACAAAGCC AAACTGAGCCCGTGCAGAGCAGGTGTGACGGAT SEQ ID NO. 396 NAG 25R - ATCCGTCACACCTGCTCTGCACGGGCTCAGTTTGGCTTT GTATCCTAAGAGACATGGTGTTGGCTCCCGTAT SEQ ID NO. 397 NAG 26F - ATACGGGAGCCAACACCACCTCCAATAGCCAAAAGAAA TCGCCAACTAACGGCAAGAGCAGGTGTGACGGAT SEQ ID NO. 398 NAG 26R - ATCCGTCACACCTGCTCTTGCCGTTAGTTGGCGATTTCTT TTGGCTATTGGAGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 399 NAG 30F - ATACGGGAGCCAACACCATCACTACTTTTATAATTTCATT CTTCTGGCGTCCCTAGAGCAGGTGTGACGGAT SEQ ID NO. 400 NAG 30R - ATCCGTCACACCTGCTCTAGGGACGCCAGAAGAATGAA ATTATAAAAGTAGTGATGGTGTTGGCTCCCGTAT N-acetyl-muramic acid (NAM) Component of Bacterial Peptidoglycan SEQ ID NO. 401 NAM 23F - ATACGGGAGCCAACACCAACTGCCCACGCCGCGACCCC GCGGCGCACCCAACCAAGAGCAGGTGTGACGGAT SEQ ID NO. 402 NAM 23R - ATCCGTCACACCTGCTCTTGGTTGGGTGCGCCGCGGGG TCGCGGCGTGGGCAGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 403 NAM 31F - ATACGGGAGCCAACACCAACGGTTACCAGGCGTGTTAA GGATATATGCTGAACCAGAGCAGGTGTGACGGAT SEQ ID NO. 404 NAM 31R - ATCCGTCACACCTGCTCTGGTTCAGCATATATCCTTAAC ACGCCTGGTAACCGTTGGTGTTGGCTCCCGTAT Salmonella typhimurium lipopolysaccharide (LPS) DNA ligands SEQ ID NO. 405 (St-7F) - ATCCGTCACACCTGCTCTGTCCAAAGGCTACGCGTTAACGT GGTGTTGGCTCCCGTAT SEQ ID NO. 406 (St-10F) - ATCCGTCACACCTGCTCTGGAGCAATATGGTGGAGAAACG TGGTGTTGGCTCCCGTAT SEQ ID NO. 407 (St-11F) - ATCCGTCACACCTGCTCTGCCGGACCATCCAATATCAGCT GTGGTGTTGGCTCCCGTAT SEQ ID NO. 408 (St-15F) - ATCCGTCACACCTGCTCTGAACAGGATAGGGATTAGCGAG TCAACTAAGCAGCATGGTGTTGGCTCCCGTAT SEQ ID NO. 409 (St-16F) - ATCCGTCACACCTGCTCTGGCGGACAGGAAATAAGAATG AACGCAAAATTTATCTGGTGTTGGCTCCCGTAT SEQ ID NO. 410 (St-18F) - ATCCGTCACACCTGCTCTACGCAACGCGACAGGAACATTC ATTATAGAATGTGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 411 (St-19F) - ATCCGTCACACCTGCTCTCGGCTGCAATGCGGGAGAGTAG GGGGGAACCAAACCTGGTGTTGGCTCCCGTAT

SEQ ID NO. 412 (St-20F) - ATCCGTCACACCTGCTCTATGACTGGAACACGGGTATCGA TGATTAGATGTCCTTGGTGTTGGCTCCCGTAT SEQ ID NO. 413 (St-7R) - ATACGGGAGCCAACACCACGTTAACGCGTAGCCTTTGGAC AGAGCAGGTGTGACGGAT SEQ ID NO. 414 (St-10R) - ATACGGGAGCCAACACCACGTTTCTCCACCATATTGCTCC AGAGCAGGTGTGACGGAT SEQ ID NO. 415 (St-11R) - ATACGGGAGCCAACACCACAGCTGATATTGGATGGTCCG GCAGAGCAGGTGTGACGGAT SEQ ID NO. 416 (St-15R) - ATACGGGAGCCAACACCATGCTGCTTAGTTGACTCGCTAA TCCCTATCCTGTTCAGAGCAGGTGTGACGGAT SEQ ID NO. 417 (St-16R) - ATACGGGAGCCAACACCAGATAAATTTTGCGTTCATTCTT ATTTCCTGTCCGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 418 (St-18R) - ATACGGGAGCCAACACCAACACATTCTATAATGAATGTT CCTGTCGCGTTGCGTAGAGCAGGTGTGACGGAT SEQ ID NO. 419 (St-19R) - ATACGGGAGCCAACACCAGGTTTGGTTCCCCCCTACTCTC CCGCATTGCAGCCGAGAGCAGGTGTGACGGAT SEQ ID NO. 420 (St-20R) - ATACGGGAGCCAACACCAAGGACATCTAATCATCGATAC CCGTGTTCCAGTCATAGAGCAGGTGTGACGGAT S. typhimurium (S. enterica serovar Typhimurium type 13311) OMPs - Fresh Bacteria SEQ ID NO. 421 (StO-2F) - ATACGGGAGCCAACACCAGATAAATTTTGCGTTCATTCT TATTTCCTGTCCGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 422 (StO-2R) - ATCCGTCACACCTGCTCTGGCGGACAGGAAATAAGAAT GAACGCAAAATTTATCTGGTGTTGGCTCCCGTAT SEQ ID NO. 423 (StO-4F) - ATACGGGAGCCAACACCAGATAAATTTTGGTTCATTCTT ATTTCCTGTCCGCCAGAGCAGGTGTGACGGAT (71) SEQ ID NO. 424 (StO-4R) - ATCCGTCACACCTGCTCTGGCGGACAGGAAATAAGAAT GAACCAAAATTTATCTGGTGTTGGCTCCCGTAT (71) SEQ ID NO. 425 (StO-5F) - ATACGGGAGCCAACACCACGGGGCTACCAGCACCGTCA CCCCTCATTCTGCCACAGAGCAGGTGTGACGGAT SEQ ID NO. 426 (StO-5R) - ATCCGTCACACCTGCTCTGTGGCAGAATGAGGGGTGAC GGTGCTGGTAGCCCCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 427 (StO-6F) - ATACGGGAGCCAACACCAAAAGATGGAAAACACTGGAA GGAAAATGCGGTCAGAGCAGGTGTGACGGAT (69) SEQ ID NO. 429 (StO-6R) - ATCCGTCACACCTGCTCTGACCGCATTTTCCTTCCAGTGT TTTCCATCTTTTGGTGTTGGCTCCCGTAT (69) SEQ ID NO. 429 (StO-7F) - ATACGGGAGCCAACACCACCGGGCCGATGGGCACCAGG AACTCTCGGACGAGTGAGAGCAGGTGTGACGGAT SEQ ID NO. 430 (StO-7R) - ATCCGTCACACCTGCTCTCACTCGTCCGAGAGTTCCTGG TGCCCATCGGCCCGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 431 (StO-8F) - ATACGGGAGCCAACACCACAGCTGATATTGGATGGTCC GGCAGAGCAGGTGTGACGGAT (59) SEQ ID NO. 432 (StO-8R) - ATCCGTCACACCTGCTCTGCCGGACCATCCAATATCAGC TGTGGTGTTGGCTCCCGTAT (59) SEQ ID NO. 433 (StO-9F) - ATACGGGAGCCAACACCAGTCGAAAGGCGGCCGTCCAG TCGAGTGATTTGACCTAGAGCAGGTGTGACGGAT SEQ ID NO. 434 (StO-9R) - ATCCGTCACACCTGCTCTAGGTCAAATCACTCGACTGGA CGGCCGCCTTTCGACTGGTGTTGGCTCCCGTAT SEQ ID NO. 435 (StO-10F) - ATACGGGAGCCAACACCACGGGGCGTGCCGTCAAAAG ACCGAGATGTGGCTGCGAGAGCAGGTGTGACGGAT SEQ ID NO. 436 (StO-10R) - ATCCGTCACACCTGCTCTCGCAGCCACATCTCGGTCTT TTGACGGCACGCCCCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 437 (StO-11/13F) - ATACGGGAGCCAACACCACTAACTTGTTGCTGATCT TATCCAGAGCAGGTGTGACGGAT (59) SEQ ID NO. 438 (StO-11/13R) - ATCCGTCACACCTGCTCTGGATAAGATCAGCAACAA GTTAGTGGTGTTGGCTCCCGTAT (59) SEQ ID NO. 439 (StO-12F) - ATACGGGAGCCAACACCATTTAGCGTAGGGCTCGCTTA T CATTTCTCATTCCCTAGAGCAGGTGTGACGGAT SEQ ID NO. 440 (StO-12R) - ATCCGTCACACCTGCTCTAGGGAATGAGAAATGATAAG CGAGCCCTACGCTAAATGGTGTTGGCTCCCGTAT SEQ ID NO. 441 (StO-14F) - ATACGGGAGCCAACACCACCGCAACCCAAATCTCTACA CGGATTATCGTCGAGCAGAGCAGGTGTGACGGAT SEQ ID NO. 442 (StO-14R) - ATCCGTCACACCTGCTCTGCTCGACGATAATCCGTGTA GAGATTTGGGTTGCGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 443 (StO-16F) - ATACGGGAGCCAACACCAACACATTCTATAATGAATGT TCCTGTCGCGTTGCGTAGAGCAGGTGTGACGGAT SEQ ID NO. 444 (StO-16R) - ATCCGTCACACCTGCTCTACGCAACGCGACAGGAACAT TCATTATAGAATGTGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 445 (StO-17F) - ATACGGGAGCCAACACCAGCCTACCCCCCCTGTACGAG GGCCGCAACCACGTAGAGAGCAGGTGTGACGGAT SEQ ID NO. 446 (StO-17R) - ATCCGTCACACCTGCTCTCTACGTGGTTGCGGCCCTCGT ACAGGGGGGGTAGGCTGGTGTTGGCTCCCGTAT SEQ ID NO. 447 (StO-18F) - ATACGGGAGCCAACACCACATCTAGCACGAGACCCTAT CCCAGAGCAGGTGTGACGGAT (59) SEQ ID NO. 448 (StO-18R) - ATCCGTCACACCTGCTCTGGGATAGGGTCTCGTGCTAG ATGTGGTGTTGGCTCCCGTAT (59) SEQ ID NO. 449 (StO-19F) - ATACGGGAGCCAACACCAACAGCGACTCGAGTCTGAC GACTCGCGGGGCAAATGAGAGCAGGTGTGACGGAT SEQ ID NO. 450 (StO-19R) - ATCCGTCACACCTGCTCTCATTTGCCCCGCGAGTCGTC AGACTCGAGTCGCTGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 451 (StO-20/24F) - ATACGGGAGCCAACACCATAGTGTTGGGCCAATACG GTAACGTGTCCTTGGAGAGCAGGTGTGACGGAT (69) SEQ ID NO. 452 (StO-20/24R) - ATCCGTCACACCTGCTCTCCAAGGACACGTTACCGT ATTGGCCCAACACTATGGTGTTGGCTCCCGTAT (69) SEQ ID NO. 453 (StO-21F) - ATACGGGAGCCAACACCACTAAGGAGAGGTCGCGACA GACTCTTCTGGTCAAGGAGAGCAGGTGTGACGGAT SEQ ID NO. 454 (StO-21R) - ATCCGTCACACCTGCTCTCCTTGACCAGAAGAGTCTGT CGCGACCTCTCCTTAGTGGTGTTGGCTCCCGTATG SEQ ID NO. 455 (StO-22F) - ATACGGGAGCCAACACCAACTTCGACTCAAAGAAGTCC ACGTGAGACTGGTGGAAGAGCAGGTGTGACGGAT SEQ ID NO. 456 (StO-22R) - ATCCGTCACACCTGCTCTTCCACCAGTCTCACGTGGAC TTCTTTGAGTCGAAGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 457 (StO-23F) - ATACGGGAGCCAACACCACCCGGGGAGACCCGCACGG GCGCACAATCCTTGTCGAGAGCAGGTGTGACGGAT SEQ ID NO. 458 (StO-23R) - ATCCGTCACACCTGCTCTCGACAAGGATTGTGCGCCCG TGCGGGTCTCCCCGGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 459 (StO-25F) - ATACGGGAGCCAACACCAGCTGGACCAAACTACGCCC ATTGTGGGGGTCCCCGGAGAGCAGGTGTGACGGAT SEQ ID NO. 460 (StO-25R) - ATCCGTCACACCTGCTCTCCGGGGACCCCCACAATGGG CGTAGTTTGGTCCAGCTGGTGTTGGCTCCCGTAT S. typhimurium (S. enterica serovar Typhimurium type 13311) Whole Cell DNA Ligands SEQ ID NO. 461 StW-4/14/24/26/39/72 F - ATACGGGAGCCAACACCATAGTGTT GGGCCAATACGGTAACGTGTCCTTGGAGAGCAGGTGTGACGGAT (69) SEQ ID NO. 462 StW-4/14/24/26/39/72 R - ATCCGTCACACCTGCTCTCCAAGGAC ACGTTACCGTATTGGCCCAACACTATGGTGTTGGCTCCCGTAT (69) SEQ ID NO. 463 StW-7 F - ATACGGGAGCCAACACCAGTGGGACCTACGGCCTTTGG CCCGCTGTTACAACGTAGAGCAGGTGTGACGGAT SEQ ID NO. 464 StW-7 R - ATCCGTCACACCTGCTCTACGTTGTAACAGCGGGCCAAA GGCCGTAGGTCCCACTGGTGTTGGCTCCCGTAT SEQ ID NO. 465 StW-9 F - ATACGGGAGCCAACACCACTTACGCATCAGCCACTCGA GAGACGGCGTTATGGCAGAGCAGGTGTGACGGAT SEQ ID NO. 466 StW-9 R - ATCCGTCACACCTGCTCTGCCATAACGCCGTCTCTCGAG TGGCTGATGCGTAAGTGGTGTTGGCTCCCGTAT SEQ ID NO. 467 StW-11 F - ATACGGGAGCCAACACCACTATAGGGTGTAGCTGATC CGCTCCCTTCTCCCAGGAGAGCAGGTGTGACGGAT SEQ ID NO. 468 StW-11 R - ATCCGTCACACCTGCTCTCCTGGGAGAAGGGAGCGGAT CAGCTACACCCTATAGTGGTGTTGGCTCCCGTAT SEQ ID NO. 469 StW-12 F - ATACGGGAGCCAACACCAGAACACCTAGAGACTAGTT CGTGTCGGCCCAGCGTGAGAGCAGGTGTGACGGAT SEQ ID NO. 470 StW-12 R - ATCCGTCACACCTGCTCTCACGCTGGGCCGACACGAAC TAGTCTCTAGGTGTTCTGGTGTTGGCTCCCGTAT SEQ ID NO. 471 StW-16 F - ATACGGGAGCCAACACCATAAGAACCACCATTCCGCGT TCGCCTCCCGAGGTGTAGAGCAGGTGTGACGGAT SEQ ID NO. 472 StW-16 R - ATCCGTCACACCTGCTCTACACCTCGGGAGGCGAACGC GGAATGGTGGTTCTTATGGTGTTGGCTCCCGTAT SEQ ID NO. 473 StW-19 F - ATACGGGAGCCAACACCAGGCCATAGGCAATTTCATAT AGCAACTGGTGAGCGTAGAGCAGGTGTGACGGAT SEQ ID NO. 474 StW-19 R - ATCCGTCACACCTGCTCTACGCTCACCAGTTGCTATAT GAAATTGCCTATGGCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 475 StW-20 F - ATACGGGAGCCAACACCAACAGAAGTCGACCCTGGTA ATCATGCTCTCTCACGGAGAGCAGGTGTGACGGAT SEQ ID NO. 476 StW-20 R - ATCCGTCACACCTGCTCTCCGTGAGAGAGCATGATTAC CAGGGTCGACTTCTGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 477 StW-22 F - ATACGGGAGCCAACACCACCAACACCTGGAGAACTTG AAACGCAGATGGTCCCCAGAGCAGGTGTGACGGAT SEQ ID NO. 478 StW-22 R - ATCCGTCACACCTGCTCTGGGGACCATCTGCGTTTCAA GTTCTCCAGGTGTTGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 479 StW-23 F - ATACGGGAGCCAACACCAGGTAGCGACATGACAGTAC CACTTACAGGACGTGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 480 StW-23 R - ATCCGTCACACCTGCTCTGGCACGTCCTGTAAGTGGTA CTGTCATGTCGCTACCTGGTGTTGGCTCCCGTAT SEQ ID NO. 481 StW-25 F - ATACGGGAGCCAACACCAATGACGTAAACACAAACGG CGGACCCAATCGTGTTCAGAGCAGGTGTGACGGAT SEQ ID NO. 482 StW-25 R - ATCCGTCACACCTGCTCTGAACACGATTGGGTCCGCCG TTTGTGTTTACGTCATTGGTGTTGGCTCCCGTAT SEQ ID NO. 483 StW-27 F - ATACGGGAGCCAACACCATGCTCCAGCATATTGATTAA TGCCAAGAGTTGGAACAGAGCAGGTGTGACGGAT SEQ ID NO. 484 StW-27 R - ATCCGTCACACCTGCTCTGTTCCAACTCTTGGCATTAAT CAATATGCTGGAGCATGGTGTTGGCTCCCGTAT SEQ ID NO. 485 StW-29 F - ATACGGGAGCCAACACCATGTGGTTCAGATGCGCCATA TCTAGACGGTCTCTGTAGAGCAGGTGTGACGGAT SEQ ID NO. 486 StW-29 R - ATCCGTCACACCTGCTCTACAGAGACCGTCTAGATATG GCGCATCTGAACCACATGGTGTTGGCTCCCGTAT SEQ ID NO. 487 StW-30 F - ATACGGGAGCCAACACCAAACCCCATTCTGTCACAGCG CCACCCAACGAGTGTTAGAGCAGGTGTGACGGAT SEQ ID NO. 488 StW-30 R - ATCCGTCACACCTGCTCTAACACTCGTTGGGTGGCGCT GTGACAGAATGGGGTTTGGTGTTGGCTCCCGTAT SEQ ID NO. 489 StW-34 F - ATACGGGAGCCAACACCAGCCGGTATCGGTGCTGAGGG CCTTGGCTTGGCTCTGAGAGCAGGTGTGACGGAT SEQ ID NO. 489 StW-34 R - ATCCGTCACACCTGCTCTCAGAGCCAAGCCAAGGCCCT CAGCACCGATACCGGCTGGTGTTGGCTCCCGTAT SEQ ID NO. 490 StW-36 F - ATACGGGAGCCAACACCATGGCGACCTAATCAGCCGGA CAGTGCTCCTCAACGTAGAGCAGGTGTGACGGAT SEQ ID NO. 491 StW-36 R - ATCCGTCACACCTGCTCTACGTTGAGGAGCACTGTCCG GCTGATTAGGTCGCCATGGTGTTGGCTCCCGTAT SEQ ID NO. 492 StW-38 F - ATACGGGAGCCAACACCATGGAGACAGGGGGAACGAC AGCGGCGGTTGCGGGGCAGAGCAGGTGTGACGGA SEQ ID NO. 493 StW-38 R - ATCCGTCACACCTGCTCTGCCCCGCAACCGCCGCTGTC

GTTCCCCCTGTCTCCATGGTGTTGGCTCCCGTAT SEQ ID NO. 494 StW-40 F - ATACGGGAGCCAACACCAATAGCCGGCCGAAATCCCTT TGGGATGGTCATACCGAGAGCAGGTGTGACGGAT SEQ ID NO. 495 StW-40 R - ATCCGTCACACCTGCTCTCGGTATGACCATCCCAAAGG GATTTCGGCCGGCTATTGGTGTTGGCTCCCGTAT SEQ ID NO. 496 StW-42 F - ATACGGGAGCCAACACCACCGAATGTGCTGCAAGACT AATCTGGATGGCCATGCAGAGCAGGTGTGACGGAT SEQ ID NO. 497 StW-42 R - ATCCGTCACACCTGCTCTGCATGGCCATCCAGATTAGTC TTGCAGCACATTCGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 498 StW-43 F - ATACGGGAGCCAACACCAAATCGAGTTCGTGACAGTTG GGCAGATACCGAGTCCAGAGCAGGTGTGACGGAT SEQ ID NO. 499 StW-43 R - ATCCGTCACACCTGCTCTGGACTCGGTATCTGCCCAAC TGTCACGAACTCGATTTGGTGTTGGCTCCCGTAT SEQ ID NO. 500 StW-45 F - ATACGGGAGCCAACACCAGGGTCCACGCTACACGGATC AAGTCTAGCTGGTTGTAGAGCAGGTGTGACGGAT SEQ ID NO. 501 StW-45 R - ATCCGTCACACCTGCTCTACAACCAGCTAGACTTGATC CGTGTAGCGTGGACCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 502 StW-47 F - ATACGGGAGCCAACACCATCCCACAAGGCTCGTGTTAG GCCTCCAATGCTCTCGAGAGCAGGTGTGACGGAT SEQ ID NO. 503 StW-47 R - ATCCGTCACACCTGCTCTCGAGAGCATTGGAGGCCTAA CACGAGCCTTGTGGGATGGTGTTGGCTCCCGTAT SEQ ID NO. 504 StW-48 F - ATACGGGAGCCAACACCAGGCCCCGAGAAATTATCGAT AGTGGTTTCTCGCCCTAGAGCAGGTGTGACGGAT SEQ ID NO. 505 StW-48 R - ATCCGTCACACCTGCTCTAGGGCGAGAAACCACTATCG ATAATTTCTCGGGGCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 506 StW-49 F - ATACGGGAGCCAACACCACACCCGGATGCGATTAAGAA GTTACTGCCTTGCGGGAGAGCAGGTGTGACGGAT SEQ ID NO. 507 StW-49 R - ATCCGTCACACCTGCTCTCCCGCAAGGCAGTAACTTCTT AATCGCATCCGGGTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 508 StW-50 F - ATACGGGAGCCAACACCATGCCATGCACTTGGTTCCGA ACGTTCGCGTCATTGCAGAGCAGGTGTGACGGAT SEQ ID NO. 509 StW-50 R - ATCCGTCACACCTGCTCTGCAATGACGCGAACGTTCGG AACCAAGTGCATGGCATGGTGTTGGCTCCCGTAT SEQ ID NO. 510 StW-56 F - ATACGGGAGCCAACACCACCAAAAAAAGCTGTGACCG GAAGGTGCTGCTGACGTAGAGCAGGTGTGACGGAT SEQ ID NO. 511 StW-56 R - ATCCGTCACACCTGCTCTACGTCAGCAGCACCTTCCGGT CACAGCTTTTTTTGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 512 StW-58 F - ATACGGGAGCCAACACCAAGCTACCATCCACCTAACAG GACTACGCGAATTGCAAGAGCAGGTGTGACGGAT SEQ ID NO. 513 StW-58 R - ATCCGTCACACCTGCTCTTGCAATTCGCGTAGTCCTGTT AGGTGGATGGTAGCTTGGTGTTGGCTCCCGTAT SEQ ID NO. 514 StW-61 F - ATACGGGAGCCAACACCACAAGCAGGAATAAGCGCCG GTCCAGAGCAGGTGTGACGGAT (59) SEQ ID NO. 515 StW-61 R - ATCCGTCACACCTGCTCTGGACCGGCGCTTATTCCTGCT TGTGGTGTTGGCTCCCGTAT (59) SEQ ID NO. 516 StW-62 F - ATACGGGAGCCAACACCACATGGACCGGCAACCTCAG AAGTAGCAAACCACCATAGAGCAGGTGTGACGGAT SEQ ID NO. 517 StW-62 R - ATCCGTCACACCTGCTCTATGGTGGTTTGCTACTTCTGA GGTTGCCGGTCCATGTGGTGTTGGCTCCCGTAT SEQ ID NO. 518 StW-65 F - ATACGGGAGCCAACACCATGTCCAAACCATTCTCGGAC CTCCCTCAGTGGCGGCAGAGCAGGTGTGACGGAT SEQ ID NO. 519 StW-65 R - ATCCGTCACACCTGCTCTGCCGCCACTGAGGGAGGTCC GAGAATGGTTTGGACATGGTGTTGGCTCCCGTAT SEQ ID NO. 520 StW-66 F - ATACGGGAGCCAACACCAGTCCGTTATGACATGTCCGG ACCCGTACGCGTGTCAAGAGCAGGTGTGACGGAT SEQ ID NO. 521 StW-66 R - ATCCGTCACACCTGCTCTTGACACGCGTACGGGTCCGG ACATGTCATAACGGACTGGTGTTGGCTCCCGTAT SEQ ID NO. 522 StW-67 F - ATACGGGAGCCAACACCATCCGCTCACATGATGCTGTA CGATGGCCGCGTGCAAAGAGCAGGTGTGACGGAT SEQ ID NO. 523 StW-67 R - ATCCGTCACACCTGCTCTTTGCACGCGGCCATCGTACA GCATCATGTGAGCGGATGGTGTTGGCTCCCGTAT SEQ ID NO. 524 StW-68 F - ATACGGGAGCCAACACCACGTCGCATATACCCCGAGAA GGTAGATCGTGGACTAGAGCAGGTGTGACGGAT (71) SEQ ID NO. 525 StW-68 R - ATCCGTCACACCTGCTCTAGTCCACGATCTACCTTCTCG GGGTATATGCGACGTGGTGTTGGCTCCCGTAT (71) SEQ ID NO. 526 StW-69 F - ATACGGGAGCCAACACCACGAGGACCTAGACTTGTCCG ACATCACAGTGTGCGAGAGCAGGTGTGACGGAT (71) SEQ ID NO. 527 StW-69 R - ATCCGTCACACCTGCTCTCGCACACTGTGATGTCGGAC AAGTCTAGGTCCTCGTGGTGTTGGCTCCCGTAT (71) SEQ ID NO. 528 StW-70 F - ATACGGGAGCCAACACCACAGCTGATATTGGATGGTCC GGCAGAGCAGGTGTGACGGAT (59) SEQ ID NO. 529 StW-70 R - ATCCGTCACACCTGCTCTGCCGGACCATCCAATATCAG CTGTGGTGTTGGCTCCCGTAT (59) SEQ ID NO. 530 StW-71 F - ATACGGGAGCCAACACCACGGGACCATCAGCCTCAACT TCCTACAAGGCCTACTAGAGCAGGTGTGACGGAT SEQ ID NO. 531 StW-71 R - ATCCGTCACACCTGCTCTAGTAGGCCTTGTAGGAAGTT GAGGCTGATGGTCCCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 532 StW-73 F - ATACGGGAGCCAACACCAATGGACAAAGGCAATAGCG TCAATTGAAGTCAGACCAGAGCAGGTGTGACGGAT SEQ ID NO. 533 StW-73 R - ATCCGTCACACCTGCTCTGGTCTGACTTCAATTGACGCT ATTGCCTTTGTCCATTGGTGTTGGCTCCCGTAT SEQ ID NO. 534 StW-74 F - ATACGGGAGCCAACACCAACTGAACTCATGAAGCACG ATTGTTGCCCCACGTGCAGAGCAGGTGTGACGGAT SEQ ID NO. 535 StW-74 R - ATCCGTCACACCTGCTCTGCACGTGGGGCAACAATCGT GCTTCATGAGTTCAGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 536 StW-76 F - ATACGGGAGCCAACACCAATCCCTAGCAAGTAAGCTGG TGGAGCTAGTACACGTAGAGCAGGTGTGACGGAT SEQ ID NO. 537 StW-76 R - ATCCGTCACACCTGCTCTACGTGTACTAGCTCCACCAGC TTACTTGCTAGGGATTGGTGTTGGCTCCCGTAT SEQ ID NO. 538 StW-78 F - ATACGGGAGCCAACACCACACCGAAAGCCGGAACGAT AGGGTACAGCTGGGTGTAGAGCAGGTGTGACGGAT SEQ ID NO. 539 StW-78 R - ATCCGTCACACCTGCTCTACACCCAGCTGTACCCTATC GTTCCGGCTTTCGGTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 540 StW-79 F - ATACGGGAGCCAACACCAAGGGCGAACTAGCATCACC TCGGTCGCTCATAGGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 541 StW-79 R - ATCCGTCACACCTGCTCTGGCCTATGAGCGACCGAGGT GATGCTAGTTCGCCCTTGGTGTTGGCTCCCGTAT SEQ ID NO. 542 StW-80 F - ATACGGGAGCCAACACCACAGGGCGACGTAAGCTCCG TCCAGAGGATGTCAGTAGAGCAGGTGTGACGGAT (71) SEQ ID NO. 543 StW-80 R - ATCCGTCACACCTGCTCTACTGACATCCTCTGGACGGA GCTTACGTCGCCCTGTGGTGTTGGCTCCCGTAT (71) Shiga-like Toxin type 1; Stx-1 SEQ ID NO. 544 (SH-2F) - ATCCGTCACACCTGCTCTGGAGACATTAAAAACCGGAG TTTATTTATACCTTTCTGGTGTTGGCTCCCGTAT SEQ ID NO. 545 (SH-2R) - ATACGGGAGCCAACACCAGAAAGGTATAAATAAACTCC GGTTTTTAATGTCTCCAGAGCAGGTGTGACGGAT SEQ ID NO. 546 (SH-3F (59)) - ATACGGGAGCCAACACCACTAACTTGTTGCTGATCT TATCCAGAGCAGGTGTGACGGAT SEQ ID NO. 547 (SH-3R (59)) - ATCCGTCACACCTGCTCTGGATAAGATCAGCAACAA GTTAGTGGTGTTGGCTCCCGTAT SEQ ID NO. 548 (SH-4F (58)) - ATCCGTCACACCTGCTCTGCATGGAGAGTTTTTTGGT CAGTGGTGTTGGCTCCCGTAT SEQ ID NO. 549 (SH-4R (58)) - ATACGGGAGCCAACACCACTGACCAAAAAACTCTC CATGCAGAGCAGGTGTGACGGAT SEQ ID NO. 550 (SH-6F (58)) - ATACGGGAGCCAACACCACGTTAACGCGTAGCCTTT GGACAGAGCAGGTGTGACGGAT SEQ ID NO. 551 (SH-6R (58)) - ATCCGTCACACCTGCTCTGTCCAAAGGCTACGCGTT AACGTGGTGTTGGCTCCCGTAT SEQ ID NO. 552 (SH-8/21/23/24/25F (59)) - ATCCGTCACACCTGCTCTGCCGG ACCATCCAATATCAGCTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 553 (SH-8/21/23/24/25 Rev (59)) - ATACGGGAGCCAACACCACA GCTGATATTGGATGGTCCGGCAGAGCAGGTGTGACGGAT SEQ ID NO. 554 (SH-9F) - ATCCGTCACACCTGCTCTCGTCCGTCATTAAGTTCGGAG GCTGGCGGGTTGCGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 555 (SH-9R) - ATACGGGAGCCAACACCAACGCAACCCGCCAGCCTCCG AACTTAATGACGGACGAGAGCAGGTGTGACGGAT SEQ ID NO. 556 (SH-10F) - ATACGGGAGCCAACACCATTCTATCGTTCCGGACGCTT ATGCCTTGCCATCTACAGAGCAGGTGTGACGGAT SEQ ID NO. 557 (SH-10R) - ATCCGTCACACCTGCTCTGTAGATGGCAAGGCATAAGC GTCCGGAACGATAGAATGGTGTTGGCTCCCGTAT SEQ ID NO. 558 (SH-11F) - TCCGTCACACCTGCTCTAACTCTTACTACTTTGTTGCTA TCACATTCAACTGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 559 (SH-11R) - ATACGGGAGCCAACACCAACAGTTGAATGTGATAGCA ACAAAGTAGTAAGAGTTAGAGCAGGTGTGACGGAT SEQ ID NO. 560 (SH-12 F(58)) - ATCCGTCACACCTGCTCTGGCCTTTCACCAAGCG TCCTTGTGGTGTTGGCTCCCGTAT SEQ ID NO. 561 (SH-12R (58)) - ATACGGGAGCCAACACCACAAGGACGCTTGGTGAA AGGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 562 (SH-16F (58)) - ATCCGTCACACCTGCTCTGGCACCGAGCACGGGAA CCCAGTGGTGTTGGCTCCCGTAT SEQ ID NO. 563 (SH-16R (58)) - ATACGGGAGCCAACACCACTGGGTTCCCGTGCTCG GTGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 564 (SH-17F (69)) - ATACGGGAGCCAACACCATAGTGTTGGGCCAATAC GGTAACGTGTCCTTGGAGAGCAGGTGTGACGGAT SEQ ID NO. 565 (SH-17R (69)) - ATCCGTCACACCTGCTCTCCAAGGACACGTTACCG TATTGGCCCAACACTATGGTGTTGGCTCCCGTAT SEQ ID NO. 567 (SH-18F) - ATCCGTCACACCTGCTCTACCCGATGCCGCCCCGGGATT GTTGTATGACCATCTTGGTGTTGGCTCCCGTAT SEQ ID NO. 568 (SH-18R) - ATACGGGAGCCAACACCAAGATGGTCATACAACAATC CCGGGGCGGCATCGGGTAGAGCAGGTGTGACGGAT SEQ ID NO. 569 (SH-19F) - ATACGGGAGCCAACACCACCCCATGAGTACACGTGAAC GGACACAGCCTCCGGCAGAGCAGGTGTGACGGAT SEQ ID NO. 570 (SH-19R) - ATCCGTCACACCTGCTCTGCCGGAGGCTGTGTCCGTTC ACGTGTACTCATGGGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 571 (SH-20F) - ATCCGTCACACCTGCTCTTAACCATTCATTTCTTTTGTG GTATGACCGTTCGCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 572 (SH-20R) - ATACGGGAGCCAACACCAGGCGAACGGTCATACCACA AAAGAAATGAATGGTTAAGAGCAGGTGTGACGGAT SEQ ID NO. 573 (SH-22F (58)) - ATCCGTCACACCTGCTCTGGGGCTCTTTTCGTTA ACCAGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 574 (SH-22R (58)) - ATACGGGAGCCAACACCACCTGGTTAACGAAAAGA GCCCCAGAGCAGGTGTGACGGAT Shiga-like toxin 2; Stx-2 SEQ ID NO. 575 S2-1 F - ATACGGGAGCCAACACCAGGCGACCAAGTTTGAATCACC ACAATCGTGACGGTGAGAGCAGGTGTGACGGAT SEQ ID NO. 576 S2-1 R - ATCCGTCACACCTGCTCTCACCGTCACGATTGTGGTGATTC AAACTTGGTCGCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 577 S2-2 F - ATACGGGAGCCAACACCACCATCACATCTTGGCCCGGTAC

CCTGGATACTAGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 578 S2-2 R - ATCCGTCACACCTGCTCTGGCTAGTATCCAGGGTACCGGG CCAAGATGTGATGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 579 S2-3 F - ATACGGGAGCCAACACCAGCACTAGCTCGGGTAACGGGG ACATTAGAGTTTGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 580 S2-3 R - ATCCGTCACACCTGCTCTGGCAAACTCTAATGTCCCCGTT ACCCGAGCTAGTGCTGGTGTTGGCTCCCGTAT SEQ ID NO. 581 S2-4 F - ATACGGGAGCCAACACCAAAGCCCACCGCGCCCAGATCT ACAAGACTTCCAACTAGAGCAGGTGTGACGGAT SEQ ID NO. 582 S2-4 R - ATCCGTCACACCTGCTCTAGTTGGAAGTCTTGTAGATCTG GGCGCGGTGGGCTTTGGTGTTGGCTCCCGTAT SEQ ID NO. 583 S2-5 F - ATACGGGAGCCAACACCATCTTTGTCACTCTGGATTAGGT TAATCCACTGAAACAGAGCAGGTGTGACGGAT SEQ ID NO. 584 S2-5 R - ATCCGTCACACCTGCTCTGTTTCAGTGGATTAACCTAATC CAGAGTGACAAAGATGGTGTTGGCTCCCGTAT SEQ ID NO. 585 S2-7 F - ATACGGGAGCCAACACCACGAACCCGGGATTCTAGCAATT GTCCCCCTCGAGCGAGAGCAGGTGTGACGGAT SEQ ID NO. 586 S2-7 R - ATCCGTCACACCTGCTCTCGCTCGAGGGGGACAATTGCTA GAATCCCGGGTTCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 587 S2-8 F - ATACGGGAGCCAACACCAATGATTAATAGAACCCCCTAT GACCTGGCCGCTGGGAGAGCAGGTGTGACGGAT SEQ ID NO. 588 S2-8 R - ATCCGTCACACCTGCTCTCCCAGCGGCCAGGTCATAGGGG GTTCTATTAATCATTGGTGTTGGCTCCCGTAT SEQ ID NO. 589 S2-9 F - ATACGGGAGCCAACACCATGGTCGGATAGCATGTCCATG TTGTCGGGTTTAACAAGAGCAGGTGTGACGGAT SEQ ID NO. 590 S2-9 R - ATCCGTCACACCTGCTCTTGTTAAACCCGACAACATGGAC ATGCTATCCGACCATGGTGTTGGCTCCCGTAT SEQ ID NO. 591 S2-10 F - ATACGGGAGCCAACACCAGGGGAATCTTGCTTGCGTAGC GACGCATAATGACGTAGAGCAGGTGTGACGGAT SEQ ID NO. 592 S2-10 R - ATCCGTCACACCTGCTCTACGTCATTATGCGTCGCTACG CAAGCAAGATTCCCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 593 S2-12 F - ATACGGGAGCCAACACCATGAAGTGGACAAATGTGCGTT CCCCTGACGTACCGGAGAGCAGGTGTGACGGAT SEQ ID NO. 594 S2-12 R - ATCCGTCACACCTGCTCTCCGGTACGTCAGGGGAACGCA CATTTGTCCACTTCATGGTGTTGGCTCCCGTA SEQ ID NO. 595 S2-13 F - ATACGGGAGCCAACACCACCATTTAGTGTTAGACTAAGT GATATCGAGTCGAGGAGAGCAGGTGTGACGGAT SEQ ID NO. 596 S2-13 R - ATCCGTCACACCTGCTCTCCTCGACTCGATATCACTTAGT CTAACACTAAATGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 597 S2-14 F - ATACGGGAGCCAACACCACTTCCACTTTTTCGCCTAATT GCCTGTTGCATGGTAAGAGCAGGTGTGACGGAT SEQ ID NO. 598 S2-14 R - ATCCGTCACACCTGCTCTTACCATGCAACAGGCAATTAG GCGAAAAAGTGGAAGTGGTGTTGGCTCCCGTAT SEQ ID NO. 599 S2-14.1 F - ATACGGGAGCCAACACCAGGCGATGTCCTAAAGTCTTT AAGGCGAATATAGTTGAGAGCAGGTGTGACGGAT SEQ ID NO. 600 S2-14.1 R - ATCCGTCACACCTGCTCTCAACTATATTCGCCTTAAAGA CTTTAGGACATCGCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 601 S2-15 F - ATACGGGAGCCAACACCACCCCCCCCTCCGTGGGCCGCT CCCCTCGGCCGGGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 602 S2-15 R - ATCCGTCACACCTGCTCTGGCCCGGCCGAGGGGAGCGGC CCACGGAGGGGGGGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 603 S2-16 F - ATACGGGAGCCAACACCATCCCGTGAAGCAACGACAATA CAAGACGAGCGAAGGAGAGCAGGTGTGACGGAT SEQ ID NO. 604 S2-16 R - ATCCGTCACACCTGCTCTCCTTCGCTCGTCTTGTATTGTC GTTGCTTCACGGGATGGTGTTGGCTCCCGTAT SEQ ID NO. 605 S2-17 F - ATACGGGAGCCAACACCACGCGACTTCTTCAACAGATAC AGAGCGCTTGGGGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 606 S2-17 R - ATCCGTCACACCTGCTCTGGCCCCAAGCGCTCTGTATCT GTTGAAGAAGTCGCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 607 S2-18 F - ATACGGGAGCCAACACCAGGAAATGGTACCTAAGAAAT GAGAACTTTGACGCACAGAGCAGGTGTGACGGAT SEQ ID NO. 607 S2-18 R - ATCCGTCACACCTGCTCTGTGCGTCAAAGTTCTCATTTCT TAGGTACCATTTCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 609 S2-19 F - ATACGGGAGCCAACACCATTAAAGTTAATCTTACACGTT TCCGACTTCCATTTGAGAGCAGGTGTGACGGAT SEQ ID NO. 610 S2-19 R - ATCCGTCACACCTGCTCTCAAATGGAAGTCGGAAACGTG TAAGATTAACTTTAATGGTGTTGGCTCCCGTAT SEQ ID NO. 611 S2-20 F - ATACGGGAGCCAACACCAAGGAGTCCGTCTACGTTTTAC GAGCTAAGGCCTTTGAGAGCAGGTGTGACGGAT SEQ ID NO. 612 S2-20 R - ATCCGTCACACCTGCTCTCAAAGGCCTTAGCTCGTAAAA CGTAGACGGACTCCTTGGTGTTGGCTCCCGTAT Cryptosporidium parvum oocysts (CP) SEQ ID NO. 613 CP 12F - ATACGGGAGCCAACACCATAATGAAGCGATGTAGCGAGTT TTTGAAAGGGACACAGAGCAGGTGTGACGGAT SEQ ID NO. 614 CP12R - ATCCGTCACACCTGCTCTGTGTCCCTTTCAAAAACTCGCTA CATCGCTTCATTATGGTGTTGGCTCCCGTAT SEQ ID NO. 615 CP 13F - ATACGGGAGCCAACACCATTTAGTCCATAGCTTCAGCGCT TCCACCTCCTTAACAGAGCAGGTGTGACGGAT SEQ ID NO. 616 CP 13R - ATCCGTCACACCTGCTCTGTTAAGGAGGTGGAAGCGCTGA AGCTATGGACTAAATGGTGTTGGCTCCCGTAT SEQ ID NO. 617 CP 15F - ATACGGGAGCCAACACCACCCGTTTTTGATCTAATGAGGA TACAATATTCGTCTAGAGCAGGTGTGACGGAT SEQ ID NO. 618 CP 15R - ATCCGTCACACCTGCTCTAGACGAATATTGTATCCTCATTA GATCAAAAACGGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 619 CP 16F - ATACGGGAGCCAACACCACCGGGTCCCCGTGATCTAGGAC AACACGGCGGTTGGAGAGCAGGTGTGACGGAT SEQ ID NO. 620 CP 16R - ATCCGTCACACCTGCTCTCCAACCGCCGTGTTGTCCTAGAT CACGGGGACCCGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 621 CP 17F - ATACGGGAGCCAACACCAGTTCAGGCATACATGATGTGGG TTCTTATTCCGTGCAGAGCAGGTGTGACGGAT SEQ ID NO. 622 CP 17R - ATCCGTCACACCTGCTCTGCACGGAATAAGAACCCACATC ATGTATGCCTGAACTGGTGTTGGCTCCCGTAT SEQ ID NO. 623 CP18F - ATACGGGAGCCAACACCAGGCAGCCCGGTCCCGGACTAAC AACCGCGGTACCCAAGAGCAGGTGTGACGGAT SEQ ID NO. 624 CP18R - ATCCGTCACACCTGCTCTTGGGTACCGCGGTTGTTAGTCCG GGACCGGGCTGCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 625 CP20F - ATACGGGAGCCAACACCATTCAGGGCTTTTGTGTATGCAC TCCAGCTATCAGACAGAGCAGGTGTGACGGAT SEQ ID NO. 626 CP20R - ATCCGTCACACCTGCTCTGTCTGATAGCTGGAGTGCATACA CAAAAGCCCTGAATGGTGTTGGCTCCCGTAT SEQ ID NO. 627 CP 21F - ATACGGGAGCCAACACCAAGGGACGGCAGGTTCGCAGCT GCGTCATCTTTCTTCAGAGCAGGTGTGACGGAT SEQ ID NO. 628 CP 21R - ATCCGTCACACCTGCTCTGAAGAAAGATGACGCAGCTGCG AACCTGCCGTCCCTTGGTGTTGGCTCCCGTAT SEQ ID NO. 629 CP 22F (71) - ATACGGGAGCCAACACCACGAGGACTTAGACTTGTCC GACATCACAGTGTGCGAGAGCAGGTGTGACGGAT SEQ ID NO. 630 CP 22R (71) - ATCCGTCACACCTGCTCTCGCACACTGTGATGTCGG ACAAGTCTAAGTCCTCGTGGTGTTGGCTCCCGTAT SEQ ID NO. 631 CP 23F - ATACGGGAGCCAACACCACTTCCCTGTCCTTCCCTCAGTG AGGCCTGTCTCCTCAGAGCAGGTGTGACGGAT SEQ ID NO. 632 CP 23R - ATCCGTCACACCTGCTCTGAGGAGACAGGCCTCACTGAGG GAAGGACAGGGAAGTGGTGTTGGCTCCCGTAT SEQ ID NO. 633 CP 24F - ATACGGGAGCCAACACCAGGAGATGTTCGTGTAATAGGGG GTTACACCCGGTCGAGAGCAGGTGTGACGGAT SEQ ID NO. 634 CP 24R - ATCCGTCACACCTGCTCTCGACCGGGTGTAACCCCCTATTA CACGAACATCTCCTGGTGTTGGCTCCCGTAT SEQ ID NO. 635 CP 25F - ATACGGGAGCCAACACCATCGCTCAAGTTCTTCATTACTCC TATCGCTTCCGCTAGAGCAGGTGTGACGGAT SEQ ID NO. 636 CP 25R - ATCCGTCACACCTGCTCTAGCGGAAGCGATAGGAGTAATG AAGAACTTGAGCGATGGTGTTGGCTCCCGTAT Giardia (UDP-N-acetylgalactosamine Surface Antigen; Gi) SEQ ID NO. 637 Gi 22F - ATACGGGAGCCAACACCATTCTACTCCCAGGTATGTCTCTG GGCCCCCCCGGCCAGAGCAGGTGTGACGGAT SEQ ID NO. 638 Gi 22R - ATCCGTCACACCTGCTCTGGCCGGGGGGGCCCAGAGACAT ACCTGGGAGTAGAATGGTGTTGGCTCCCGTAT SEQ ID NO. 639 Gi 25F - ATACGGGAGCCAACACCAACAACATAGCCCTGGCACGAC AGTGGCATACCAGGCAGAGCAGGTGTGACGGAT SEQ ID NO. 640 Gi 25R - ATCCGTCACACCTGCTCTGCCTGGTATGCCACTGTCGTGCC AGGGCTATGTTGTTGGTGTTGGCTCCCGTAT SEQ ID NO. 641 Gi 30F - ATACGGGAGCCAACACCACGTAATGATGTGCACCTCTCTC CGACTGTTTCTCGTAGAGCAGGTGTGACGGAT SEQ ID NO. 642 Gi 30R - ATCCGTCACACCTGCTCTACGAGAAACAGTCGGAGAGAGG TGCACATCATTACGTGGTGTTGGCTCCCGTAT SEQ ID NO. 643 Gi-33F - ATACGGGAGCCAACACCACATCTTATTCGTCCCCAGTCCT TTGGTCTCCTGCTCAGAGCAGGTGTGACGGAT SEQ ID NO. 644 Gi-33R - TCCGTCACACCTGCTCTGAGCAGGAGACCAAAGGACTG GGGACGAATAAGATGTGGTGTTGGCTCCCGTAT SEQ ID NO. 645 Gi-37F - ATACGGGAGCCAACACCACCTGCTGATTTCCTATAATCC GGCCCATACCTTAGGAGAGCAGGTGTGACGGAT SEQ ID NO. 646 Gi-37R - ATCCGTCACACCTGCTCTCCTAAGGTATGGGCCGGATTA TAGGAAATCAGCAGGTGGTGTTGGCTCCCGTAT SEQ ID NO. 647 Gi-38F - ATACGGGAGCCAACACCATAAGAGTCCTCTAAGGTCGCT TATTTTTAACCCCTAAGAGCAGGTGTGACGGAT SEQ ID NO. 648 Gi-38R - ATCCGTCACACCTGCTCTTAGGGGTTAAAAATAAGCGAC CTTAGAGGACTCTTATGGTGTTGGCTCCCGTAT SEQ ID NO. 649 Gi-40F - ATACGGGAGCCAACACCATCCCCACACCCTCGTTCCGACC GCTAGAATCCCCGAAGAGCAGGTGTGACGGAT SEQ ID NO. 650 Gi-40R - ATCCGTCACACCTGCTCTTCGGGGATTCTAGCGGTCGGAA CGAGGGTGTGGGGATGGTGTTGGCTCCCGTAT

Sequence CWU 1

1

12081136DNAArtificial Sequencechemically synthesized 1catccgtcac acctgctctg gggagggtgg cgcccgtctc ggtggtgttg gctcccgtat 60casdncdnaa rtcacatccg tcacacctgc tctgggatag ggtctcgtgc tagatgtggt 120gttggctccc gtatca 136262DNAArtificial Sequencechemically synthesized 2catccgtcac acctgctctg gaccggcgct tattcctgct tgtggtgttg gctcccgtat 60ca 62362DNAArtificial Sequencechemically synthesized 3catccgtcac acctgctctg gagctgatat tggatggtcc ggtggtgttg gctcccgtat 60ca 62462DNAArtificial Sequencechemically synthesized 4catccgtcac acctgctctg cccagagcag gtgtgacgga tgtggtgttg gctcccgtat 60ca 62562DNAArtificial Sequencechemically synthesized 5catccgtcac acctgctctg ccggaccatc caatatcagc tgtggtgttg gctcccgtat 60ca 62672DNAArtificial Sequencechemically synthesized 6atacgggagc caacaccagg accaaaataa ataatcacaa taaaaatgct tcctagagca 60ggtgtgacgg at 72772DNAArtificial Sequencechemically synthesized 7atccgtcaca cctgctctag gaagcatttt tattgtgatt atttattttg gtcctggtgt 60tggctcccgt at 72872DNAArtificial Sequencechemically synthesized 8atacgggagc caacaccacg ccgggccata ggcgtgtggt agcatactcg tactagagca 60ggtgtgacgg at 72972DNAArtificial Sequencechemically synthesized 9atccgtcaca cctgctctag tacgagtatg ctaccacacg cctatggccc ggcgtggtgt 60tggctcccgt at 721072DNAArtificial Sequencechemically synthesized 10atacgggagc caacaccata gtataaagac ccaattgaca gactatccta ggctagagca 60ggtgtgacgg at 721172DNAArtificial Sequencechemically synthesized 11atccgtcaca cctgctctag cctaggatag tctgtcaatt gggtctttat actatggtgt 60tggctcccgt at 721272DNAArtificial Sequencechemically synthesized 12atacgggagc caacaccaag aggggacaga gggtataaga caactattct ccccagagca 60ggtgtgacgg at 721372DNAArtificial Sequencechemically synthesized 13atccgtcaca cctgctctgg ggagaatagt tgtcttatac cctctgtccc ctcttggtgt 60tggctcccgt at 721472DNAArtificial Sequencechemically synthesized 14atacgggagc caacaccagg cggccgcaac ttggtcccct cttcatcctc ggatagagca 60ggtgtgacgg at 721572DNAArtificial Sequencechemically synthesized 15atccgtcaca cctgctctat ccgaggatga agaggggacc aagttgcggc cgcctggtgt 60tggctcccgt at 721669DNAArtificial Sequencechemically synthesized 16atacgggagc caacaccata gtgttggacc aatacggtaa cgtgtccttg gagagcaggt 60gtgacggat 691769DNAArtificial Sequencechemically synthesized 17atccgtcaca cctgctctcc aaggacacgt taccgtattg gtccaacact atggtgttgg 60ctcccgtat 691872DNAArtificial Sequencechemically synthesized 18atacgggagc caacaccacg cgatacaatg tgctaaaaaa gttcgtgccc ctgcagagca 60ggtgtgacgg at 721972DNAArtificial Sequencechemically synthesized 19atccgtcaca cctgctctgc aggggcacga acttttttag cacattgtat cgcgtggtgt 60tggctcccgt at 722072DNAArtificial Sequencechemically synthesized 20atacgggagc caacaccacg ccgaatagtg ttcgtatgcc acccgcacgt gtctagagca 60ggtgtgacgg at 722172DNAArtificial Sequencechemically synthesized 21atccgtcaca cctgctctag acacgtgcgg gtggcatacg aacactattc ggcgtggtgt 60tggctcccgt at 722272DNAArtificial Sequencechemically synthesized 22atacgggagc caacaccagg catgactaaa aaggataacc taatctcttg ttccagagca 60ggtgtgacgg at 722372DNAArtificial Sequencechemically synthesized 23atccgtcaca cctgctctgg aacaagagat taggttatcc tttttagtca tgcctggtgt 60tggctcccgt at 722472DNAArtificial Sequencechemically synthesized 24atacgggagc caacaccata cagtccaccg tatactagtg gtacccaggc gtcgagagca 60ggtgtgacgg at 722572DNAArtificial Sequencechemically synthesized 25atccgtcaca cctgctctcg acgcctgggt accactagta tacggtggac tgtatggtgt 60tggctcccgt at 722672DNAArtificial Sequencechemically synthesized 26atacgggagc caacaccagg gggcgaacag ttacccttgg tctggaccac tgccagagca 60ggtgtgacgg at 722772DNAArtificial Sequencechemically synthesized 27atccgtcaca cctgctctgg cagtggtcca gaccaagggt aactgttcgc cccctggtgt 60tggctcccgt at 722872DNAArtificial Sequencechemically synthesized 28atacgggagc caacaccagg ggcgtcgggc caggcgacgg ccgccgtttc cggcagagca 60ggtgtgacgg at 722972DNAArtificial Sequencechemically synthesized 29atccgtcaca cctgctctgc cggaaacggc ggccgtcgcc tggcccgacg cccctggtgt 60tggctcccgt at 723072DNAArtificial Sequencechemically synthesized 30atacgggagc caacaccacg ggccgtccct ggcccggggg ggcgaaacgc gctgagagca 60ggtgtgacgg at 723172DNAArtificial Sequencechemically synthesized 31atccgtcaca cctgctctca gcgcgtttcg cccccccggg ccagggacgg cccgtggtgt 60tggctcccgt at 723272DNAArtificial Sequencechemically synthesized 32atacgggagc caacaccagg cgattactaa gggaaaaaag tgtaaaacct acccagagca 60ggtgtgacgg at 723372DNAArtificial Sequencechemically synthesized 33atccgtcaca cctgctctgg gtaggtttta cacttttttc ccttagtaat cgcctggtgt 60tggctcccgt at 723472DNAArtificial Sequencechemically synthesized 34atacgggagc caacaccacc acccactggc ccggtccgcg gccgcgcgcg ccccagagca 60ggtgtgacgg at 723572DNAArtificial Sequencechemically synthesized 35atccgtcaca cctgctctgg ggcgcgcgcg gccgcggacc gggccagtgg gtggtggtgt 60tggctcccgt at 723672DNAArtificial Sequencechemically synthesized 36atacgggagc caacaccaac gatatccctg accaaagacg ttaaatgctt ccatagagca 60ggtgtgacgg at 723772DNAArtificial Sequencechemically synthesized 37atccgtcaca cctgctctat ggaagcattt aacgtctttg gtcagggata tcgttggtgt 60tggctcccgt at 723872DNAArtificial Sequencechemically synthesized 38atacgggagc caacaccagg gcggggggtt ggcgagcagg aatcgagaga ggtgagagca 60ggtgtgacgg at 723972DNAArtificial Sequencechemically synthesized 39atccgtcaca cctgctctca cctctctcga ttcctgctcg ccaacccccc gccctggtgt 60tggctcccgt at 724072DNAArtificial Sequencechemically synthesized 40atacgggagc caacaccaga tgcgcttcct gtaatgaaca gatcatattt atgtagagca 60ggtgtgacgg at 724172DNAArtificial Sequencechemically synthesized 41atccgtcaca cctgctctac ataaatatga tctgttcatt acaggaagcg catctggtgt 60tggctcccgt at 724272DNAArtificial Sequencechemically synthesized 42atacgggagc caacaccaag gtaggttgcc gcaggttggc gacaaaccag gttgagagca 60ggtgtgacgg at 724372DNAArtificial Sequencechemically synthesized 43atccgtcaca cctgctctca acctggtttg tcgccaacct gcggcaacct accttggtgt 60tggctcccgt at 724469DNAArtificial Sequencechemically synthesized 44atacgggagc caacaccata gtgttggacc aatacggtaa cgtgtccttg gagagcaggt 60gtgacggat 694569DNAArtificial Sequencechemically synthesized 45atccgtcaca cctgctctcc aaggacacgt taccgtattg gtccaacact atggtgttgg 60ctcccgtat 694672DNAArtificial Sequencechemically synthesized 46atacgggagc caacaccacc cgggtggcgg ggtgggtgtg ggtcgacgtt ctggagagca 60ggtgtgacgg at 724772DNAArtificial Sequencechemically synthesized 47atccgtcaca cctgctctcc agaacgtcga cccacaccca ccccgccacc cgggtggtgt 60tggctcccgt at 724872DNAArtificial Sequencechemically synthesized 48atacgggagc caacaccagg ggggggtggc cgcaggaaat atgcagtcca ctatagagca 60ggtgtgacgg at 724972DNAArtificial Sequencechemically synthesized 49atccgtcaca cctgctctat agtggactgc atatttcctg cggccacccc cccctggtgt 60tggctcccgt at 725072DNAArtificial Sequencechemically synthesized 50atacgggagc caacaccaca caccgggccc gcccccagcg cccccctacg cacaagagca 60ggtgtgacgg at 725172DNAArtificial Sequencechemically synthesized 51atccgtcaca cctgctcttg tgcgtagggg ggcgctgggg gcgggcccgg tgtgtggtgt 60tggctcccgt at 725272DNAArtificial Sequencechemically synthesized 52atacgggagc caacaccatg aaggaaacct tgatagcagg aatagtccat tcccagagca 60ggtgtgacgg at 725372DNAArtificial Sequencechemically synthesized 53atccgtcaca cctgctctgg gaatggacta ttcctgctat caaggtttcc ttcatggtgt 60tggctcccgt at 725472DNAArtificial Sequencechemically synthesized 54atacgggagc caacaccacc cgggtggcgg ggtgggtgtg ggtcgacgtt ctggagagca 60ggtgtgacgg at 725572DNAArtificial Sequencechemically synthesized 55atccgtcaca cctgctctcc agaacgtcga cccacaccca ccccgccacc cgggtggtgt 60tggctcccgt at 725672DNAArtificial Sequencechemically synthesized 56atacgggagc caacaccacg cccgccggcg actcgctcca ctccgtcccg ctccagagca 60ggtgtgacgg at 725772DNAArtificial Sequencechemically synthesized 57atccgtcaca cctgctctgg agcgggacgg agtggagcga gtcgccggcg ggcgtggtgt 60tggctcccgt at 725872DNAArtificial Sequencechemically synthesized 58cattcaccac acctctgctg gcttggctag ccttgatgct aaacgaccca tagtgtggtg 60tcgtcccgta tc 725972DNAArtificial Sequencechemically synthesized 59gatacgggac gacaccacac tatgggtcgt ttagcatcaa ggctagccaa gccagcagag 60gtgtggtgaa tg 726072DNAArtificial Sequencechemically synthesized 60cattcaccac acctctgctg gaggaggaag tggtctggag ttacttgaca tagtgtggtg 60tcgtcccgta tc 726172DNAArtificial Sequencechemically synthesized 61gatacgggac gacaccacac tatgtcaagt aactccagac cacttcctcc tccagcagag 60gtgtggtgaa tg 726272DNAArtificial Sequencechemically synthesized 62cattcaccac acctctgctg gacggaaaca atccccgggt acgagaatca gggtgtggtg 60tcgtcccgta tc 726372DNAArtificial Sequencechemically synthesized 63gatacgggac gacaccacac cctgattctc gtacccgggg attgtttccg tccagcagag 60gtgtggtgaa tg 726472DNAArtificial Sequencechemically synthesized 64cattcaccac acctctgctg gaaacctacc attaatgaga catgatgcgg tggtgtggtg 60tcgtcccgta tc 726572DNAArtificial Sequencechemically synthesized 65gatacgggac gacaccacac caccgcatca tgtctcatta atggtaggtt tccagcagag 60gtgtggtgaa tg 726672DNAArtificial Sequencechemically synthesized 66atccgtcaca cctgctctgg tggaatggac taagctagct agcgttttaa aaggtggtgt 60tggctcccgt at 726772DNAArtificial Sequencechemically synthesized 67atccgtcaca cctgctctgt aagggggggg aatcgctttc gtcttaagat gacatggtgt 60tggctcccgt at 726859DNAArtificial Sequencechemically synthesized 68atccgtcaca cctgctctgc cggaccatcc aatatcagct gtggtgttgg ctcccgtat 596971DNAArtificial Sequencechemically synthesized 69atccgtcaca cctgctctat ccgtcacgcc tgctctatcc gtcacacctg ctctggtgtt 60ggctcccgta t 717072DNAArtificial Sequencechemically synthesized 70atccgtcaca cctgctctat caaatgtgca gatatcaaga cgatttgtac aagatggtgt 60tggctcccgt at 727172DNAArtificial Sequencechemically synthesized 71atccgtcaca cctgctctgt agatggcaag gcataagcgt ccggaacgat agaatggtgt 60tggctcccgt at 727272DNAArtificial Sequencechemically synthesized 72atccgtcaca cctgctctgt agatggcaag gcataagcgt ccggaacgat agaatggtgt 60tggctcccgt at 727372DNAArtificial Sequencechemically synthesized 73atacgggagc caacaccacc ttttaaaacg ctagctagct tagtccattc caccagagca 60ggtgtgacgg at 727472DNAArtificial Sequencechemically synthesized 74atacgggagc caacaccatg tcatcttaag acgaaagcga ttcccccccc ttacagagca 60ggtgtgacgg at 727559DNAArtificial Sequencechemically synthesized 75atacgggagc caacaccaca gctgatattg gatggtccgg cagagcaggt gtgacggat 597671DNAArtificial Sequencechemically synthesized 76atacgggagc caacaccaga gcaggtgtga cggatagagc aggcgtgacg gatagagcag 60gtgtgacgga t 717772DNAArtificial Sequencechemically synthesized 77atacgggagc caacaccatc ttgtacaaat cgtcttgata tctgcacatt tgatagagca 60ggtgtgacgg at 727872DNAArtificial Sequencechemically synthesized 78atacgggagc caacaccatt ctatcgttcc ggacgcttat gccttgccat ctacagagca 60ggtgtgacgg at 727972DNAArtificial Sequencechemically synthesized 79atacgggagc caacaccatt ctatcgttcc ggacgcttat gccttgccat ctacagagca 60ggtgtgacgg at 728072DNAArtificial Sequencechemically synthesized 80atacgggagc caacaccatg gtacaagcaa accaatatta gggcccagac atcgagagca 60ggtgtgacgg at 728172DNAArtificial Sequencechemically synthesized 81atccgtcaca cctgctctcg atgtctgggc cctaatattg gtttgcttgt accatggtgt 60tggctcccgt at 728272DNAArtificial Sequencechemically synthesized 82atacgggagc caacaccatg ataccctaag gtaggggagg cctaagcgcc acgtagagca 60ggtgtgacgg at 728372DNAArtificial Sequencechemically synthesized 83atccgtcaca cctgctctac gtggcgctta ggcctcccct accttagggt atcatggtgt 60tggctcccgt at 728472DNAArtificial Sequencechemically synthesized 84atacgggagc caacaccacg catcccccgc cgggcccgcg ccccgctcgc agacagagca 60ggtgtgacgg at 728572DNAArtificial Sequencechemically synthesized 85atccgtcaca cctgctctgt ctgcgagcgg ggcgcgggcc cggcggggga tgcgtggtgt 60tggctcccgt

at 728673DNAArtificial Sequencechemically synthesized 86atacgggagc caacaccata atatgccgta aggagaggcc tgttgggagc gccgtagagc 60aggtgtgacg gat 738773DNAArtificial Sequencechemically synthesized 87atccgtcaca cctgctctac ggcgctccca acaggcctct ccttacggca tattatggtg 60ttggctcccg tat 738872DNAArtificial Sequencechemically synthesized 88atacgggagc caacaccagg aaaaaaagag cctgtgaaga ttgtaatatc agttagagca 60ggtgtgacgg at 728971DNAArtificial Sequencechemically synthesized 89atccgtcaca cctgctctaa ctgatattac aatcttcaca ggctcttttt ttcctggtgt 60ggctcccgta t 719072DNAArtificial Sequencechemically synthesized 90atccgtcaca cctgctctcg gaggtagact aggattgcgg cggggggtca ggtatggtgt 60tggctcccgt at 729171DNAArtificial Sequencechemically synthesized 91atacgggagc caacaccaca aaagccttac ctaactgcca acaatgaata gcaagagcag 60gtgtgacgga t 719272DNAArtificial Sequencechemically synthesized 92atccgtcaca cctgctcttg ctattcattg ttggcagtta ggtaaggctt ttgttggtgt 60tggctcccgt at 729372DNAArtificial Sequencechemically synthesized 93atacgggagc caacaccata cctgaccccc cgccgcaatc ctagtctacc tccgagagca 60ggtgtgacgg at 729472DNAArtificial Sequencechemically synthesized 94atacgggagc caacaccacg actaacacga ccgttggggg gggctcgcgc gggcagagca 60ggtgtgacgg at 729572DNAArtificial Sequencechemically synthesized 95atccgtcaca cctgctctgc ccgcgcgagc cccccccaac ggtcgtgtta gtcgtggtgt 60tggctcccgt at 729672DNAArtificial Sequencechemically synthesized 96atacgggagc caacaccagt ccccgcccag ccgtgagccg tacccccgca caccagagca 60ggtgtgacgg at 729772DNAArtificial Sequencechemically synthesized 97atccgtcaca cctgctctgg tgtgcggggg tacggctcac ggctgggcgg ggactggtgt 60tggctcccgt at 729872DNAArtificial Sequencechemically synthesized 98atccgtcaca cctgctctca aggttgggcc tgcaagagca aaaacggggc gggatggtgt 60tggctcccgt at 729972DNAArtificial Sequencechemically synthesized 99atacgggagc caacaccatc ccgccccgtt tttgctcttg caggcccaac cttgagagca 60ggtgtgacgg at 7210072DNAArtificial Sequencechemically synthesized 100atccgtcaca cctgctctac ttggcttgcg actattattc acagggccaa agactggtgt 60tggctcccgt at 7210172DNAArtificial Sequencechemically synthesized 101atacgggagc caacaccagt ctttggccct gtgaataata gtcgcaagcc aagtagagca 60ggtgtgacgg at 7210269DNAArtificial Sequencechemically synthesized 102atacgggagc caacaccata gtgttggacc aatacggtaa cgtgtccttg gagagcaggt 60gtgacggat 6910369DNAArtificial Sequencechemically synthesized 103atccgtcaca cctgctctcc aaggacacgt taccgtattg gtccaacact atggtgttgg 60ctcccgtat 6910472DNAArtificial Sequencechemically synthesized 104atccgtcaca cctgctcttg gaatgtcggt gtttttccaa ttccttgggt cgtgtggtgt 60tggctcccgt at 7210572DNAArtificial Sequencechemically synthesized 105atacgggagc caacaccaca cgacccaagg aattggaaaa acaccgacat tccaagagca 60ggtgtgacgg at 7210672DNAArtificial Sequencechemically synthesized 106atccgtcaca cctgctctgc gacggcgacg cggtccgggc gggggtggag gacgtggtgt 60tggctcccgt at 7210772DNAArtificial Sequencechemically synthesized 107atacgggagc caacaccacg tcctccaccc ccgcccggac cgcgtcgccg tcgcagagca 60ggtgtgacgg at 7210872DNAArtificial Sequencechemically synthesized 108atacgggagc caacaccaga gggttctagg gtcacttcca tgagaatggc tcacagagca 60ggtgtgacgg at 7210972DNAArtificial Sequencechemically synthesized 109atccgtcaca cctgctctgg cctggggacg cgagggaggc ggggggagtc gtggtggtgt 60tggctcccgt at 7211072DNAArtificial Sequencechemically synthesized 110atacgggagc caacaccacc acgactcccc ccgcctccct cgcgtcccca ggccagagca 60ggtgtgacgg at 7211172DNAArtificial Sequencechemically synthesized 111atccgtcaca cctgctctgt gagccattct catggaagtg accctagaac cctctggtgt 60tggctcccgt at 7211272DNAArtificial Sequencechemically synthesized 112atccgtcaca cctgctctca cagggcctct tactatacag ttctccagcg ctgctggtgt 60tggctcccgt at 7211372DNAArtificial Sequencechemically synthesized 113atacgggagc caacaccagc agcgctggag aactgtatag taagaggccc tgtgagagca 60ggtgtgacgg at 7211472DNAArtificial Sequencechemically synthesized 114atccgtcaca cctgctctgc acgggctcag tttggctttg tatcctaaga gagatggtgt 60tggctcccgt at 7211572DNAArtificial Sequencechemically synthesized 115atacgggagc caacaccatc tctcttagga tacaaagcca aactgagccc gtgcagagca 60ggtgtgacgg at 7211671DNAArtificial Sequencechemically synthesized 116atacgggagc caacaccagg ggtggcgaac atggtataac ttgataagtg tgaagagcag 60gtgtgacgga t 7111772DNAArtificial Sequencechemically synthesized 117atccgtcaca cctgctcttc acacttatca agttatacca tgttcgccac cccctggtgt 60tggctcccgt at 7211872DNAArtificial Sequencechemically synthesized 118atacgggagc caacaccact ccgacaccgg ccgccggcac cacccactcc ccctagagca 60ggtgtgacgg at 7211972DNAArtificial Sequencechemically synthesized 119atccgtcaca cctgctctag ggggagtggg tggtgccggc ggccggtgtc ggagtggtgt 60tggctcccgt at 7212072DNAArtificial Sequencechemically synthesized 120atacgggagc caacaccatc cggcgcgccc tcctccccca ctgctccccg cccgagagca 60ggtgtgacgg at 7212172DNAArtificial Sequencechemically synthesized 121atccgtcaca cctgctctcg ggcggggagc agtgggggag gagggcgcgc cggatggtgt 60tggctcccgt at 7212272DNAArtificial Sequencechemically synthesized 122atacgggagc caacaccata cgcagaggtc ccctacccag gccagccgga tgccagagca 60ggtgtgacgg at 7212372DNAArtificial Sequencechemically synthesized 123atccgtcaca cctgctctgg catccggctg gcctgggtag gggacctctg cgtatggtgt 60tggctcccgt at 7212472DNAArtificial Sequencechemically synthesized 124atacgggagc caacaccacg aggattacaa ctttatgcgt gcaaccagac accaagagca 60ggtgtgacgg at 7212572DNAArtificial Sequencechemically synthesized 125atccgtcaca cctgctcttg gtgtctggtt gcacgcataa agttgtaatc ctcgtggtgt 60tggctcccgt at 7212672DNAArtificial Sequencechemically synthesized 126atacgggagc caacaccata taaacgagga aataaaactg cagaacactt cctcagagca 60ggtgtgacgg at 7212772DNAArtificial Sequencechemically synthesized 127atccgtcaca cctgctctga ggaagtgttc tgcagtttta tttcctcgtt tatatggtgt 60tggctcccgt at 7212871DNAArtificial Sequencechemically synthesized 128atacgggagc caacaccatc acggcaatgt cccgataatg tcttgcttca gcgagagcag 60gtgtgacgga t 7112971DNAArtificial Sequencechemically synthesized 129atccgtcaca cctgctctcg ctgaagcaag acattatcgg gacattgccg tgatggtgtt 60ggctcccgta t 7113072DNAArtificial Sequencechemically synthesized 130atacgggagc caacaccaag caatcagtat acccacccgt caaaaacatc atgcagagca 60ggtgtgacgg at 7213172DNAArtificial Sequencechemically synthesized 131atccgtcaca cctgctctgc atgatgtttt tgacgggtgg gtatactgat tgcttggtgt 60tggctcccgt at 7213272DNAArtificial Sequencechemically synthesized 132atacgggagc caacaccacg gcttcttgcg cccccccgcg cccgcgcccc ccccagagca 60ggtgtgacgg at 7213372DNAArtificial Sequencechemically synthesized 133atccgtcaca cctgctctgg ggggggcgcg ggcgcggggg ggcgcaagaa gccgtggtgt 60tggctcccgt at 7213472DNAArtificial Sequencechemically synthesized 134atacgggagc caacaccaac ggaggatgaa gagataaagt aaatatccgg gggcagagca 60ggtgtgacgg at 7213572DNAArtificial Sequencechemically synthesized 135atccgtcaca cctgctctgc ccccggatat ttactttatc tcttcatcct ccgttggtgt 60tggctcccgt at 7213672DNAArtificial Sequencechemically synthesized 136atacgggagc caacaccacc cgtggccttc acccagccag gggccccgtc tctgagagca 60ggtgtgacgg at 7213772DNAArtificial Sequencechemically synthesized 137atccgtcaca cctgctctca gagacggggc ccctggctgg gtgaaggcca cgggtggtgt 60tggctcccgt at 7213872DNAArtificial Sequencechemically synthesized 138atacgggagc caacaccaca ctaccgtccc accccctccc agctcctccg gccgagagca 60ggtgtgacgg at 7213972DNAArtificial Sequencechemically synthesized 139atccgtcaca cctgctctcg gccggaggag ctgggagggg gtgggacggt agtgtggtgt 60tggctcccgt at 7214072DNAArtificial Sequencechemically synthesized 140atacgggagc caacaccaat cccccgcctg cgaccgatgc actcccatat gtcgagagca 60ggtgtgacgg at 7214172DNAArtificial Sequencechemically synthesized 141atccgtcaca cctgctctcg acatatggga gtgcatcggt cgcaggcggg ggattggtgt 60tggctcccgt at 7214272DNAArtificial Sequencechemically synthesized 142atacgggagc caacaccata catgcccaag gtttcgggtg aggctaccgt gagtagagca 60ggtgtgacgg at 7214372DNAArtificial Sequencechemically synthesized 143atccgtcaca cctgctctac tcacggtagc ctcacccgaa accttgggca tgtatggtgt 60tggctcccgt at 7214472DNAArtificial Sequencechemically synthesized 144atacgggagc caacaccatt tatgtttcat actttaaact tggtcgtttg cgatagagca 60ggtgtgacgg at 7214572DNAArtificial Sequencechemically synthesized 145atccgtcaca cctgctctat cgcaaacgac caagtttaaa gtatgaaaca taaatggtgt 60tggctcccgt at 7214672DNAArtificial Sequencechemically synthesized 146atacgggagc caacaccagg cgtttaataa tcggagcgac aaattctacg ctgtagagca 60ggtgtgacgg at 7214772DNAArtificial Sequencechemically synthesized 147atccgtcaca cctgctctac agcgtagaat ttgtcgctcc gattattaaa cgcctggtgt 60tggctcccgt at 7214872DNAArtificial Sequencechemically synthesized 148atacgggagc caacaccacg gcaacttcaa acccaagact aagaaaagct cgtgagagca 60ggtgtgacgg at 7214972DNAArtificial Sequencechemically synthesized 149atccgtcaca cctgctctca cgagcttttc ttagtcttgg gtttgaagtt gccgtggtgt 60tggctcccgt at 7215072DNAArtificial Sequencechemically synthesized 150atacgggagc caacaccatt gtaggcggat attagacaag accgaattcc atggagagca 60ggtgtgacgg at 7215172DNAArtificial Sequencechemically synthesized 151atccgtcaca cctgctctcc atggaattcg gtcttgtcta atatccgcct acaatggtgt 60tggctcccgt at 7215272DNAArtificial Sequencechemically synthesized 152atacgggagc caacaccagt aggctaaagt gaggttaatt atgtcgacaa ggccagagca 60ggtgtgacgg at 7215372DNAArtificial Sequencechemically synthesized 153atccgtcaca cctgctctgg ccttgtcgac ataattaacc tcactttagc ctactggtgt 60tggctcccgt at 7215472DNAArtificial Sequencechemically synthesized 154atacgggagc caacaccacc tcgcccagac gccgggccct ccccgcccca ccccagagca 60ggtgtgacgg at 7215572DNAArtificial Sequencechemically synthesized 155atccgtcaca cctgctctgg ggtggggcgg ggagggcccg gcgtctgggc gaggtggtgt 60tggctcccgt at 7215672DNAArtificial Sequencechemically synthesized 156atacgggagc caacaccagg tattggagct atacacgtta accaccgcta ttgcagagca 60ggtgtgacgg at 7215772DNAArtificial Sequencechemically synthesized 157atccgtcaca cctgctctgc aatagcggtg gttaacgtgt atagctccaa tacctggtgt 60tggctcccgt at 7215872DNAArtificial Sequencechemically synthesized 158atacgggagc caacaccacg cggggcgggg gggctggtcg cgcgggcctg gcggagagca 60ggtgtgacgg at 7215972DNAArtificial Sequencechemically synthesized 159atccgtcaca cctgctctcc gccaggcccg cgcgaccagc ccccccgccc cgcgtggtgt 60tggctcccgt at 7216072DNAArtificial Sequencechemically synthesized 160atacgggagc caacaccaaa cattggaaca acaaacgcta atacacgatc gcatagagca 60ggtgtgacgg at 7216172DNAArtificial Sequencechemically synthesized 161atccgtcaca cctgctctat gcgatcgtgt attagcgttt gttgttccaa tgtttggtgt 60tggctcccgt at 7216272DNAArtificial Sequencechemically synthesized 162atacgggagc caacaccaat agatggataa gggggaaact gccattcggt tagtagagca 60ggtgtgacgg at 7216372DNAArtificial Sequencechemically synthesized 163atccgtcaca cctgctctac taaccgaatg gcagtttccc ccttatccat ctattggtgt 60tggctcccgt at 7216472DNAArtificial Sequencechemically synthesized 164atacgggagc caacaccaac caacgaagaa gggtcagaca aaaaggagtt ctcgagagca 60ggtgtgacgg at 7216572DNAArtificial Sequencechemically synthesized 165atccgtcaca cctgctctcg agaactcctt tttgtctgac ccttcttcgt tggttggtgt 60tggctcccgt at 7216672DNAArtificial Sequencechemically synthesized 166atacgggagc caacaccaca acagtcagat tgcaactgag tagtacatac gttaagagca 60ggtgtgacgg at 7216772DNAArtificial Sequencechemically synthesized 167atccgtcaca cctgctctta acgtatgtac tactcagttg caatctgact gttgtggtgt 60tggctcccgt at 7216872DNAArtificial Sequencechemically synthesized 168atacgggagc caacaccata aaccaagggt gtaacagaaa tgatgtgacc aggcagagca 60ggtgtgacgg at 7216972DNAArtificial Sequencechemically synthesized 169atccgtcaca

cctgctctgc ctggtcacat catttctgtt acacccttgg tttatggtgt 60tggctcccgt at 7217072DNAArtificial Sequencechemically synthesized 170atacgggagc caacaccatc attgcgacat tgaattcaga aggaggagtg gtgtagagca 60ggtgtgacgg at 7217172DNAArtificial Sequencechemically synthesized 171atccgtcaca cctgctctac accactcctc cttctgaatt caatgtcgca atgatggtgt 60tggctcccgt at 7217271DNAArtificial Sequencechemically synthesized 172atacgggagc caacaccaga gaattacaac aggttaagta gtgtgacgat catagagcag 60gtgtgacgga t 7117371DNAArtificial Sequencechemically synthesized 173atccgtcaca cctgctctat gatcgtcaca ctacttaacc tgttgtaatt ctctggtgtt 60ggctcccgta t 7117472DNAArtificial Sequencechemically synthesized 174atacgggagc caacaccacg gcggaacaca tggaacaccg aataatgtgg cttaagagca 60ggtgtgacgg at 7217572DNAArtificial Sequencechemically synthesized 175atccgtcaca cctgctctta agccacatta ttcggtgttc catgtgttcc gccgtggtgt 60tggctcccgt at 7217672DNAArtificial Sequencechemically synthesized 176atacgggagc caacaccagc gtggtggacg tataacaaga cagaagtaac ccgtagagca 60ggtgtgacgg at 7217772DNAArtificial Sequencechemically synthesized 177atccgtcaca cctgctctac gggttacttc tgtcttgtta tacgtccacc acgctggtgt 60tggctcccgt at 7217871DNAArtificial Sequencechemically synthesized 178atacgggagc caacaccatg acaaacatca atgcagcaaa gactagcaac gtgagagcag 60gtgtgacgga t 7117971DNAArtificial Sequencechemically synthesized 179atccgtcaca cctgctctca cgttgctagt ctttgctgca ttgatgtttg tcatggtgtt 60ggctcccgta t 7118071DNAArtificial Sequencechemically synthesized 180atacgggagc caacaccagc cggcaatggc tgagagagaa tagagcgtgg tatagagcag 60gtgtgacgga t 7118171DNAArtificial Sequencechemically synthesized 181atccgtcaca cctgctctat accacgctct attctctctc agccattgcc ggctggtgtt 60ggctcccgta t 7118272DNAArtificial Sequencechemically synthesized 182atacgggagc caacaccaag ggggcggcga gtcgtagcgt cgataatact ggacagagca 60ggtgtgacgg at 7218372DNAArtificial Sequencechemically synthesized 183atccgtcaca cctgctctgt ccagtattat cgacgctacg actcgccgcc cccttggtgt 60tggctcccgt at 7218472DNAArtificial Sequencechemically synthesized 184atacgggagc caacaccagc ccggagccct tcgtctgccc gcagtccagt gtatagagca 60ggtgtgacgg at 7218572DNAArtificial Sequencechemically synthesized 185atccgtcaca cctgctctat acactggact gcgggcagac gaagggctcc gggctggtgt 60tggctcccgt at 7218672DNAArtificial Sequencechemically synthesized 186atacgggagc caacaccatc cgcgcccccg cggcatccgc tcacgcgtcc cggcagagca 60ggtgtgacgg at 7218772DNAArtificial Sequencechemically synthesized 187atccgtcaca cctgctctgc cgggacgcgt gagcggatgc cgcgggggcg cggatggtgt 60tggctcccgt at 7218872DNAArtificial Sequencechemically synthesized 188atacgggagc caacaccatg caggacaaag cgatgagata cgatctaccg ctcgagagca 60ggtgtgacgg at 7218972DNAArtificial Sequencechemically synthesized 189atccgtcaca cctgctctcg agcggtagat cgtatctcat cgctttgtcc tgcatggtgt 60tggctcccgt at 7219072DNAArtificial Sequencechemically synthesized 190atacgggagc caacaccatg gagaggaaga cggaaagtat ggagtggatg aaggagagca 60ggtgtgacgg at 7219172DNAArtificial Sequencechemically synthesized 191atccgtcaca cctgctctcc ttcatccact ccatactttc cgtcttcctc tccatggtgt 60tggctcccgt at 7219272DNAArtificial Sequencechemically synthesized 192atacgggagc caacaccacg aaggagtaaa gcatgctgtc cctatgagct gggaagagca 60ggtgtgacgg at 7219372DNAArtificial Sequencechemically synthesized 193atccgtcaca cctgctcttc ccagctcata gggacagcat gctttactcc ttcgtggtgt 60tggctcccgt at 7219472DNAArtificial Sequencechemically synthesized 194atacgggagc caacaccacc ctgagacata cctagtcaag tggaacagac aggtagagca 60ggtgtgacgg at 7219572DNAArtificial Sequencechemically synthesized 195atccgtcaca cctgctctac ctgtctgttc cacttgacta ggtatgtctc agggtggtgt 60tggctcccgt at 7219672DNAArtificial Sequencechemically synthesized 196atacgggagc caacaccagt agggagaagt tcgaatgaaa atacgctacg aacaagagca 60ggtgtgacgg at 7219772DNAArtificial Sequencechemically synthesized 197atccgtcaca cctgctcttg ttcgtagcgt attttcattc gaacttctcc ctactggtgt 60tggctcccgt at 7219872DNAArtificial Sequencechemically synthesized 198atacgggagc caacaccact ccctaccggc tctgcgggaa atatgttttg acccagagca 60ggtgtgacgg at 7219972DNAArtificial Sequencechemically synthesized 199atccgtcaca cctgctctgg gtcaaaacat atttcccgca gagccggtag ggagtggtgt 60tggctcccgt at 7220072DNAArtificial Sequencechemically synthesized 200atacgggagc caacaccacc cgtggccttc acccagccag gggccccgtc tctgagagca 60ggtgtgacgg at 7220172DNAArtificial Sequencechemically synthesized 201atccgtcaca cctgctctca gagacggggc ccctggctgg gtgaaggcca cgggtggtgt 60tggctcccgt at 7220272DNAArtificial Sequencechemically synthesized 202atacgggagc caacaccaca aagtcctccc ccctgggcgc cttcacccca ctgcagagca 60ggtgtgacgg at 7220372DNAArtificial Sequencechemically synthesized 203atccgtcaca cctgctctgc ggtggggtga aggcgcccag gggggaggac tttgtggtgt 60tggctcccgt at 7220472DNAArtificial Sequencechemically synthesized 204atacgggagc caacaccatg gtagacagcg tcgccctgcc atcactccgg ccccagagca 60ggtgtgacgg at 7220572DNAArtificial Sequencechemically synthesized 205atccgtcaca cctgctctgg ggccggagtg atggcagggc gacgctgtct accatggtgt 60tggctcccgt at 7220672DNAArtificial Sequencechemically synthesized 206atacgggagc caacaccacg atcccggcgc gacggatgta aaataagtgt gctcagagca 60ggtgtgacgg at 7220772DNAArtificial Sequencechemically synthesized 207atccgtcaca cctgctctga gcacacttat tttacatccg tcgcgccggg atcgtggtgt 60tggctcccgt at 7220872DNAArtificial Sequencechemically synthesized 208atacgggagc caacaccagg gaagatatgc aacagatggt ggaccgtagt atggagagca 60ggtgtgacgg at 7220972DNAArtificial Sequencechemically synthesized 209atccgtcaca cctgctctcc atactacggt ccaccatctg ttgcatatct tccctggtgt 60tggctcccgt at 7221072DNAArtificial Sequencechemically synthesized 210atacgggagc caacaccaca gcagggtact gtagtggtgg ggggccggtc cgggagagca 60ggtgtgacgg at 7221172DNAArtificial Sequencechemically synthesized 211atccgtcaca cctgctctcc cggaccggcc ccccaccact acagtaccct gctgtggtgt 60tggctcccgt at 7221272DNAArtificial Sequencechemically synthesized 212atacgggagc caacaccaag acggacaggg gacgtcggtg aagcgacgga ttggagagca 60ggtgtgacgg at 7221372DNAArtificial Sequencechemically synthesized 213atccgtcaca cctgctctcc aatccgtcgc ttcaccgacg tcccctgtcc gtcttggtgt 60tggctcccgt at 7221472DNAArtificial Sequencechemically synthesized 214atacgggagc caacaccaca cgagccaggt aaaagtaagc cacacaaagt gctcagagca 60ggtgtgacgg at 7221572DNAArtificial Sequencechemically synthesized 215atccgtcaca cctgctctga gcactttgtg tggcttactt ttacctggct cgtgtggtgt 60tggctcccgt at 7221672DNAArtificial Sequencechemically synthesized 216atacgggagc caacaccacc acgcgacacc ccctcctgtc ccccgcccgc ttccagagca 60ggtgtgacgg at 7221772DNAArtificial Sequencechemically synthesized 217atccgtcaca cctgctctgg aagcgggcgg gggacaggag ggggtgtcgc gtggtggtgt 60tggctcccgt at 7221872DNAArtificial Sequencechemically synthesized 218atacgggagc caacaccatc gagaagcatt gataacaaaa tttaaacccc tgccagagca 60ggtgtgacgg at 7221972DNAArtificial Sequencechemically synthesized 219atccgtcaca cctgctctgg caggggttta aattttgtta tcaatgcttc tcgatggtgt 60tggctcccgt at 7222072DNAArtificial Sequencechemically synthesized 220atacgggagc caacaccatc gagaagcatt gataacaaaa tttaaacccc tgccagagca 60ggtgtgacgg at 7222172DNAArtificial Sequencechemically synthesized 221atccgtcaca cctgctctgg caggggttta aattttgtta tcaatgcttc tcgatggtgt 60tggctcccgt at 7222272DNAArtificial Sequencechemically synthesized 222atacgggagc caacaccagg atccgtagaa tgatttaaat aaacacgaac acatagagca 60ggtgtgacgg at 7222372DNAArtificial Sequencechemically synthesized 223atccgtcaca cctgctctat gtgttcgtgt ttatttaaat cattctacgg atcctggtgt 60tggctcccgt at 7222472DNAArtificial Sequencechemically synthesized 224atccgtcaca cctgctctaa ttaggatacg gggcaacaga acgagagggg ggaatggtgt 60tggctcccgt at 7222571DNAArtificial Sequencechemically synthesized 225atccgtcaca cctgctctcg gaccaggtca gacaagcaca tcggatatcc ggctggtgtt 60ggctcccgta t 7122672DNAArtificial Sequencechemically synthesized 226atccgtcaca cctgctcttg agtcaaagag tttagggagg agctaacata acagtggtgt 60tggctcccgt at 7222772DNAArtificial Sequencechemically synthesized 227atccgtcaca cctgctctaa caacaatgca tcagcgggct gggaacgcat gcggtggtgt 60tggctcccgt at 7222872DNAArtificial Sequencechemically synthesized 228atccgtcaca cctgctctga acaggttata agcaggagtg atagtttcag gatctggtgt 60tggctcccgt at 7222971DNAArtificial Sequencechemically synthesized 229atccgtcaca cctgctctcg gcggctcgca aaccgagtgg tcagcacccg ggttggtgtt 60ggctcccgta t 7123072DNAArtificial Sequencechemically synthesized 230atccgtcaca cctgctctgc gcaagacgta atccacaaga ccgtgaaaac atagtggtgt 60tggctcccgt at 7223172DNAArtificial Sequencechemically synthesized 231atacgggagc caacaccatt cccccctctc gttctgttgc cccgtatcct aattagagca 60ggtgtgacgg at 7223271DNAArtificial Sequencechemically synthesized 232atacgggagc caacaccagc cggatatccg atgtgcttgt ctgacctggt ccgagagcag 60gtgtgacgga t 7123372DNAArtificial Sequencechemically synthesized 233atacgggagc caacaccact gttatgttag ctcctcccta aactctttga ctcaagagca 60ggtgtgacgg at 7223472DNAArtificial Sequencechemically synthesized 234atacgggagc caacaccacc gcatgcgttc ccagcccgct gatgcattgt tgttagagca 60ggtgtgacgg at 7223572DNAArtificial Sequencechemically synthesized 235atacgggagc caacaccaga tcctgaaact atcactcctg cttataacct gttcagagca 60ggtgtgacgg at 7223671DNAArtificial Sequencechemically synthesized 236atacgggagc caacaccaac ccgggtgctg accactcggt ttgcgagccg ccgagagcag 60gtgtgacgga t 7123772DNAArtificial Sequencechemically synthesized 237atacgggagc caacaccact atgttttcac ggtcttgtgg attacgtctt gcgcagagca 60ggtgtgacgg at 7223872DNAArtificial Sequencechemically synthesized 238atccgtcaca cctgctctag gcgtagtgac taagtcgcgc gaaaatcaca gcattggtgt 60tggctcccgt at 7223972DNAArtificial Sequencechemically synthesized 239atccgtcaca cctgctctca gcggcagcta tacagtgaga acggactagt gcgttggtgt 60tggctcccgt at 7224072DNAArtificial Sequencechemically synthesized 240atccgtcaca cctgctctgg caaataatac tagcgatgat ggatctggat agactggtgt 60tggctcccgt at 7224172DNAArtificial Sequencechemically synthesized 241atccgtcaca cctgctctgg gggtgcgact tagggtaagt gggaaagacg atgctggtgt 60tggctcccgt at 7224272DNAArtificial Sequencechemically synthesized 242atccgtcaca cctgctctca agaggagatg aaccaatctt agtccgacag gcggtggtgt 60tggctcccgt at 7224372DNAArtificial Sequencechemically synthesized 243atccgtcaca cctgctctgg cccggaattg tcatgacgtc acctacacct cctgtggtgt 60tggctcccgt at 7224472DNAArtificial Sequencechemically synthesized 244atacgggagc caacaccaat gctgtgattt tcgcgcgact tagtcactac gcctagagca 60ggtgtgacgg at 7224572DNAArtificial Sequencechemically synthesized 245atacgggagc caacaccaac gcactagtcc gttctcactg tatagctgcc gctgagagca 60ggtgtgacgg at 7224672DNAArtificial Sequencechemically synthesized 246atacgggagc caacaccagt ctatccagat ccatcatcgc tagtattatt tgccagagca 60ggtgtgacgg at 7224772DNAArtificial Sequencechemically synthesized 247atacgggagc caacaccagc atcgtctttc ccacttaccc taagtcgcac ccccagagca 60ggtgtgacgg at 7224872DNAArtificial Sequencechemically synthesized 248atacgggagc caacaccacc gcctgtcgga ctaagattgg ttcatctcct cttgagagca 60ggtgtgacgg at 7224972DNAArtificial Sequencechemically synthesized 249atacgggagc caacaccaca ggaggtgtag gtgacgtcat gacaattccg ggccagagca 60ggtgtgacgg at 7225072DNAArtificial Sequencechemically synthesized 250atccgtcacc cctgctctcg tcgctatgaa gtaacaaaga taggagcaat cgggtggtgt 60tggctcccgt at 7225172DNAArtificial Sequencechemically synthesized 251atccgtcaca cctgctctaa cgaagactga aaccaaagca gtgacagtgc tgaatggtgt 60tggctcccgt at 7225272DNAArtificial Sequencechemically synthesized 252atccgtcaca cctgctctcg gtgacaatag ctcgatcagc ccaaagtcgt cagatggtgt 60tggctcccgt at

7225371DNAArtificial Sequencechemically synthesized 253atccgtcaca cctgctctaa cgaaatagac cacaaatcga tactttatgt tattggtgtt 60ggctcccgta t 7125472DNAArtificial Sequencechemically synthesized 254atccgtcaca cctgctctgt cgaatgctct gcctggaaga gttgttagca gggatggtgt 60tggctcccgt at 7225572DNAArtificial Sequencechemically synthesized 255atccgtcaca cctgctctta agccgagggg taaatctagg acaggggtcc atgatggtgt 60tggctcccgt at 7225672DNAArtificial Sequencechemically synthesized 256atccgtcaca cctgctctac tggccggctc agcatgacta agaaggaagt tatgtggtgt 60tggctcccgt at 7225772DNAArtificial Sequencechemically synthesized 257atccgtcaca cctgctctgg tacgaatcac aggggatgct ggaagcttgg ctcttggtgt 60tggctcccgt at 7225872DNAArtificial Sequencechemically synthesized 258atacgggagc caacaccacc cgattgctcc tatctttgtt acttcatagc gacgagagca 60ggggtgacgg at 7225972DNAArtificial Sequencechemically synthesized 259atacgggagc caacaccatt cagcactgtc actgctttgg tttcagtctt cgttagagca 60ggtgtgacgg at 7226072DNAArtificial Sequencechemically synthesized 260atacgggagc caacaccatc tgacgacttt gggctgatcg agctattgtc accgagagca 60ggtgtgacgg at 7226171DNAArtificial Sequencechemically synthesized 261atacgggagc caacaccaat aacataaagt atcgatttgt ggtctatttc gttagagcag 60gtgtgacgga t 7126272DNAArtificial Sequencechemically synthesized 262atacgggagc caacaccatc cctgctaaca actcttccag gcagagcatt cgacagagca 60ggtgtgacgg at 7226372DNAArtificial Sequencechemically synthesized 263atacgggagc caacaccatc atggacccct gtcctagatt tacccctcgg cttaagagca 60ggtgtgacgg at 7226472DNAArtificial Sequencechemically synthesized 264atacgggagc caacaccaca taacttcctt cttagtcatg ctgagccggc cagtagagca 60ggtgtgacgg at 7226572DNAArtificial Sequencechemically synthesized 265atacgggagc caacaccaag agccaagctt ccagcatccc ctgtgattcg taccagagca 60ggtgtgacgg at 7226672DNAArtificial Sequencechemically synthesized 266atccgtcaca cctgctctcc gcacgtagga ccactttggt acacgctccc gtagtggtgt 60tggctcccgt at 7226772DNAArtificial Sequencechemically synthesized 267atccgtcaca cctgctctac ggatgaacga agattttaaa gtcaagctaa tgcatggtgt 60tggctcccgt at 7226872DNAArtificial Sequencechemically synthesized 268atccgtcaca cctgctctgt agtgaagagt ccgcagtcca cgctgttcaa ctcatggtgt 60tggctcccgt at 7226972DNAArtificial Sequencechemically synthesized 269atccgtcaca cctgctctac cggctggcac ggttatgtgt gacgggcgaa gatatggtgt 60tggctcccgt at 7227058DNAArtificial Sequencechemically synthesized 270atccgtcaca cctgctctgc gtgtggagcg cctaggtgag tggtgttggc tcccgtat 5827172DNAArtificial Sequencechemically synthesized 271atccgtcaca cctgctctga tgtccctttg aagagttcca tgacgctggc tccttggtgt 60tggctcccgt at 7227272DNAArtificial Sequencechemically synthesized 272atacgggagc caacaccact acgggagcgt gtaccaaagt ggtcctacgt gcggagagca 60ggtgtgacgg at 7227372DNAArtificial Sequencechemically synthesized 273atacgggagc caacaccatg cattagcttg actttaaaat cttcgttcat ccgtagagca 60ggtgtgacgg at 7227472DNAArtificial Sequencechemically synthesized 274atacgggagc caacaccatg agttgaacag cgtggactgc ggactcttca ctacagagca 60ggtgtgacgg at 7227572DNAArtificial Sequencechemically synthesized 275atacgggagc caacaccata tcttcgcccg tcacacataa ccgtgccagc cggtagagca 60ggtgtgacgg at 7227658DNAArtificial Sequencechemically synthesized 276atacgggagc caacaccact cacctaggcg ctccacacgc agagcaggtg tgacggat 5827772DNAArtificial Sequencechemically synthesized 277atacgggagc caacaccaag gagccagcgt catggaactc ttcaaaggga catcagagca 60ggtgtgacgg at 7227859DNAArtificial Sequencechemically synthesized 278atccgtcaca cctgctctgc cggaccatcc aatatcagct gtggtgttgg ctcccgtat 5927972DNAArtificial Sequencechemically synthesized 279atccgtcaca cctgctctgg tggaatggac taagctagct agcgttttaa aaggtggtgt 60tggctcccgt at 7228072DNAArtificial Sequencechemically synthesized 280atccgtcaca cctgctctta aagtagaggc tgttctccag acgtcgcagg aggatggtgt 60tggctcccgt at 7228172DNAArtificial Sequencechemically synthesized 281atccgtcaca cctgctctgt agatggcaag gcataagcgt ccggaacgat agaatggtgt 60tggctcccgt at 7228272DNAArtificial Sequencechemically synthesized 282atccgtcaca cctgctctgt agatggcaag gcataagcgt ccggaacgat agaatggtgt 60tggctcccgt at 7228359DNAArtificial Sequencechemically synthesized 283atacgggagc caacaccaca gctgatattg gatggtccgg cagagcaggt gtgacggat 5928472DNAArtificial Sequencechemically synthesized 284atccgtcaca cctgctcttg ggcaggagcg agagactcta atggtaagca agaatggtgt 60tggctcccgt at 7228572DNAArtificial Sequencechemically synthesized 285atccgtcaca cctgctctcc aacaaggcga ccgaccgcat gcagatagcc aggttggtgt 60tggctcccgt at 7228659DNAArtificial Sequencechemically synthesized 286atacgggagc caacaccaca gctgatattg gatggtccgg cagagcaggt gtgacggat 5928772DNAArtificial Sequencechemically synthesized 287atacgggagc caacaccacc ttttaaaacg ctagctagct tagtccattc caccagagca 60ggtgtgacgg at 7228872DNAArtificial Sequencechemically synthesized 288atacgggagc caacaccatc ctcctgcgac gtctggagaa cagcctctac tttaagagca 60ggtgtgacgg at 7228972DNAArtificial Sequencechemically synthesized 289atacgggagc caacaccatt ctatcgttcc ggacgcttat gccttgccat ctacagagca 60ggtgtgacgg at 7229072DNAArtificial Sequencechemically synthesized 290atacgggagc caacaccatt ctatcgttcc ggacgcttat gccttgccat ctacagagca 60ggtgtgacgg at 7229159DNAArtificial Sequencechemically synthesized 291atccgtcaca cctgctctgc cggaccatcc aatatcagct gtggtgttgg ctcccgtat 5929272DNAArtificial Sequencechemically synthesized 292atacgggagc caacaccatt cttgcttacc attagagtct ctcgctcctg cccaagagca 60ggtgtgacgg at 7229372DNAArtificial Sequencechemically synthesized 293atacgggagc caacaccaac ctggctatct gcatgcggtc ggtcgccttg ttggagagca 60ggtgtgacgg at 7229472DNAArtificial Sequencechemically synthesized 294atccgtcaca cctgctctgt agatggcaag gcataagcgt ccggaacgat agaatggtgt 60tggctcccgt at 7229572DNAArtificial Sequencechemically synthesized 295atccgtcaca cctgctctaa ccaaaagggt aggagaccaa gctagcgatt tggatggtgt 60tggctcccgt at 7229659DNAArtificial Sequencechemically synthesized 296atccgtcaca cctgctctgc cggaccatcc aatatcagct gtggtgttgg ctcccgtat 5929772DNAArtificial Sequencechemically synthesized 297atccgtcaca cctgctctga agcctaacgg agaagatggc cctactgccg taggtggtgt 60tggctcccgt at 7229872DNAArtificial Sequencechemically synthesized 298atccgtcaca cctgctctac taaacaaggg caaactgtaa acacagtagg ggcgtggtgt 60tggctcccgt at 7229968DNAArtificial Sequencechemically synthesized 299atccgtcaca cctgctctgg tgttggctcc cgtatagctt ggctcccgta tggtgttggc 60tcccgtat 6830072DNAArtificial Sequencechemically synthesized 300atccgtcaca cctgctctgt cgcgatgatg agcagcagcg caggagggag ggggtggtgt 60tggctcccgt at 7230157DNAArtificial Sequencechemically synthesized 301atccgtcaca cctgctctga tcagggaaga cgccaacact ggtgttggct cccgtat 5730272DNAArtificial Sequencechemically synthesized 302atacgggagc caacaccatt ctatcgttcc ggacgcttat gccttgccat ctacagagca 60ggtgtgacgg at 7230372DNAArtificial Sequencechemically synthesized 303atacgggagc caacaccatc caaatcgcta gcttggtctc ctaccctttt ggttagagca 60ggtgtgacgg at 7230459DNAArtificial Sequencechemically synthesized 304atacgggagc caacaccaca gctgatattg gatggtccgg cagagcaggt gtgacggat 5930572DNAArtificial Sequencechemically synthesized 305atacgggagc caacaccacc tacggcagta gggccatctt ctccgttagg cttcagagca 60ggtgtgacgg at 7230672DNAArtificial Sequencechemically synthesized 306atacgggagc caacaccacg cccctactgt gtttacagtt tgcccttgtt tagtagagca 60ggtgtgacgg at 7230768DNAArtificial Sequencechemically synthesized 307atacgggagc caacaccata cgggagccaa gctatacggg agccaacacc agagcaggtg 60tgacggat 6830872DNAArtificial Sequencechemically synthesized 308atacgggagc caacaccacc ccctccctcc tgcgctgctg ctcatcatcg cgacagagca 60ggtgtgacgg at 7230957DNAArtificial Sequencechemically synthesized 309atacgggagc caacaccagt gttggcgtct tccctgatca gagcaggtgt gacggat 5731071DNAArtificial Sequencechemically synthesized 310atacgggagc caacaccaat acctgtaaaa gtctgagaag tggagtaacc tagagagcag 60gtgtgacgga t 7131171DNAArtificial Sequencechemically synthesized 311atccgtcaca cctgctctct aggttactcc acttctcaga cttttacagg tattggtgtt 60ggctcccgta t 7131272DNAArtificial Sequencechemically synthesized 312atacgggagc caacaccacc gaccaacagt aatagcctaa aagagttatg cgctagagca 60ggtgtgacgg at 7231372DNAArtificial Sequencechemically synthesized 313atccgtcaca cctgctctag cgcataactc ttttaggcta ttactgttgg tcggtggtgt 60tggctcccgt at 7231472DNAArtificial Sequencechemically synthesized 314atacgggagc caacaccagg tggactatat atgaagttag tgagctttaa caggagagca 60ggtgtgacgg at 7231572DNAArtificial Sequencechemically synthesized 315atccgtcaca cctgctctcc tgttaaagct cactaacttc atatatagtc cacctggtgt 60tggctcccgt at 7231672DNAArtificial Sequencechemically synthesized 316atacgggagc caacaccaca ggagaggcag taaaagggtt ggctgcctgg gtagagagca 60ggtgtgacgg at 7231772DNAArtificial Sequencechemically synthesized 317atccgtcaca cctgctctct acccaggcag ccaacccttt tactgcctct cctgtggtgt 60tggctcccgt at 7231872DNAArtificial Sequencechemically synthesized 318atacgggagc caacaccatt agcaaggtaa gaacagtttt aatacatgcc ttccagagca 60ggtgtgacgg at 7231972DNAArtificial Sequencechemically synthesized 319atccgtcaca cctgctctgg aaggcatgta ttaaaactgt tcttaccttg ctaatggtgt 60tggctcccgt at 7232072DNAArtificial Sequencechemically synthesized 320atacgggagc caacaccata acaaataacc accctcaatg ctagatagtg gcttagagca 60ggtgtgacgg at 7232172DNAArtificial Sequencechemically synthesized 321atccgtcaca cctgctctaa gccactatct agcattgagg gtggttattt gttatggtgt 60tggctcccgt at 7232272DNAArtificial Sequencechemically synthesized 322atacgggagc caacaccagg aacatgataa gtgagaagtg cgacgttagc ttatagagca 60ggtgtgacgg at 7232372DNAArtificial Sequencechemically synthesized 323atccgtcaca cctgctctat aagctaacgt cgcacttctc acttatcatg ttcctggtgt 60tggctcccgt at 7232472DNAArtificial Sequencechemically synthesized 324atacgggagc caacaccaaa agggtgttca tacggaatgt agatcgccta agtgagagca 60ggtgtgacgg at 7232572DNAArtificial Sequencechemically synthesized 325atccgtcaca cctgctctca cttaggcgat ctacattccg tatgaacacc cttttggtgt 60tggctcccgt at 7232672DNAArtificial Sequencechemically synthesized 326atacgggagc caacaccatg agcaccggca aacgcgtagg ttaagctaca tgacagagca 60ggtgtgacgg at 7232772DNAArtificial Sequencechemically synthesized 327atccgtcaca cctgctctgt catgtagctt aacctacgcg tttgccggtg ctcatggtgt 60tggctcccgt at 7232872DNAArtificial Sequencechemically synthesized 328atacgggagc caacaccatg attagatact gcctagctgt gtgctcgttg ggggagagca 60ggtgtgacgg at 7232972DNAArtificial Sequencechemically synthesized 329atccgtcaca cctgctctcc cccaacgagc acacagctag gcagtatcta atcatggtgt 60tggctcccgt at 72330158DNAArtificial Sequencechemically synthesized 330atacgggagc caacaccagg aggaaggtca gcgttcttca cgtggctagg gggcagagca 60ggtgtgacgg atsdnmwrdn aartcaatcc gtcacacctg ctctgccccc tagccacgtg 120aagaacgctg accttcctcc tggtgttggc tcccgtat 15833172DNAArtificial Sequencechemically synthesized 331atacgggagc caacaccaac tgagctatat ctagatcgac ttacacatac acgtagagca 60ggtgtgacgg at 7233272DNAArtificial Sequencechemically synthesized 332atccgtcaca cctgctctac gtgtatgtgt aagtcgatct agatatagct cagttggtgt 60tggctcccgt at 7233372DNAArtificial Sequencechemically synthesized 333atacgggagc caacaccaga gacgtgtgaa gtccaggcag ggtgccttct gtcgagagca 60ggtgtgacgg at 7233472DNAArtificial Sequencechemically synthesized 334atccgtcaca cctgctctcg acagaaggca ccctgcctgg acttcacacg tctctggtgt 60tggctcccgt at 7233572DNAArtificial Sequencechemically synthesized 335atacgggagc caacaccatc aagtggtgag cgcctcgtcg ggaactgccg tgcgagagca 60ggtgtgacgg at 7233672DNAArtificial Sequencechemically synthesized 336atccgtcaca cctgctctcg cacggcagtt cccgacgagg cgctcaccac ttgatggtgt 60tggctcccgt at 7233772DNAArtificial Sequencechemically synthesized 337atacgggagc caacaccacc gctgaaacct ctccgccgtc ccgccctcct ccccagagca 60ggtgtgacgg at 7233872DNAArtificial Sequencechemically synthesized 338atccgtcaca cctgctctgg ggaggagggc gggacggcgg agaggtttca gcggtggtgt 60tggctcccgt at 7233972DNAArtificial Sequencechemically synthesized 339atacgggagc caacaccagg agatggtagc actaaaatac gacgtatgct gtgtagagca 60ggtgtgacgg

at 7234072DNAArtificial Sequencechemically synthesized 340atccgtcaca cctgctctac acagcatacg tcgtatttta gtgctaccat ctcctggtgt 60tggctcccgt at 7234172DNAArtificial Sequencechemically synthesized 341atacgggagc caacaccaaa tcgaccggac taatcctgtg actcccctat gtctagagca 60ggtgtgacgg at 7234272DNAArtificial Sequencechemically synthesized 342atccgtcaca cctgctctag acatagggga gtcacaggat tagtccggtc gatttggtgt 60tggctcccgt at 7234372DNAArtificial Sequencechemically synthesized 343atacgggagc caacaccaaa ttcaattgcg cacgtaagaa tagataggct gaccagagca 60ggtgtgacgg at 7234472DNAArtificial Sequencechemically synthesized 344atccgtcaca cctgctctgg tcagcctatc tattcttacg tgcgcaattg aatttggtgt 60tggctcccgt at 7234572DNAArtificial Sequencechemically synthesized 345atacgggagc caacaccaca cacagagcgc catggactca gtcagatgtg atgtagagca 60ggtgtgacgg at 7234672DNAArtificial Sequencechemically synthesized 346atccgtcaca cctgctctac atcacatctg actgagtcca tggcgctctg tgtgtggtgt 60tggctcccgt at 7234772DNAArtificial Sequencechemically synthesized 347atacgggagc caacaccatc caatgaggcc atggaccggt aaactcggac gcgcagagca 60ggtgtgacgg at 7234872DNAArtificial Sequencechemically synthesized 348atccgtcaca cctgctctgc gcgtccgagt ttaccggtcc atggcctcat tggatggtgt 60tggctcccgt at 7234972DNAArtificial Sequencechemically synthesized 349atacgggagc caacaccaac cccggtacca tccgacacca cgagcacccg gacgagagca 60ggtgtgacgg at 7235072DNAArtificial Sequencechemically synthesized 350atccgtcaca cctgctctcg tccgggtgct cgtggtgtcg gatggtaccg gggttggtgt 60tggctcccgt at 7235172DNAArtificial Sequencechemically synthesized 351atacgggagc caacaccaag gcgaaactat tcacagagac tgatccagca aggtagagca 60ggtgtgacgg at 7235272DNAArtificial Sequencechemically synthesized 352atccgtcaca cctgctctac cttgctggat cagtctctgt gaatagtttc gccttggtgt 60tggctcccgt at 7235372DNAArtificial Sequencechemically synthesized 353atacgggagc caacaccaaa cacatagtcg tggcagaacg aatacttagc gcggagagca 60ggtgtgacgg at 7235472DNAArtificial Sequencechemically synthesized 354atccgtcaca cctgctctcc gcgctaagta ttcgttctgc cacgactatg tgtttggtgt 60tggctcccgt at 7235572DNAArtificial Sequencechemically synthesized 355atacgggagc caacaccaac acgatcgacg gcgcttggtc ccttacaacc ctgcagagca 60ggtgtgacgg at 7235672DNAArtificial Sequencechemically synthesized 356atccgtcaca cctgctctgc agggttgtaa gggaccaagc gccgtcgatc gtgttggtgt 60tggctcccgt at 7235772DNAArtificial Sequencechemically synthesized 357atacgggagc caacaccaaa ccaggactct gtcgctctaa acatgaccat cgatagagca 60ggtgtgacgg at 7235872DNAArtificial Sequencechemically synthesized 358atccgtcaca cctgctctat cgatggtcat gtttagagcg acagagtcct ggtttggtgt 60tggctcccgt at 7235971DNAArtificial Sequencechemically synthesized 359atacgggagc caacaccaca accactgtag gctcatgtaa ctacccgttg ttgagagcag 60gtgtgacgga t 7136071DNAArtificial Sequencechemically synthesized 360atccgtcaca cctgctctca acaacgggta gttacatgag cctacagtgg ttgtggtgtt 60ggctcccgta t 7136172DNAArtificial Sequencechemically synthesized 361atacgggagc caacaccagg ggacaagcag aaccgaacag attgcaacgt atccagagca 60ggtgtgacgg at 7236272DNAArtificial Sequencechemically synthesized 362atccgtcaca cctgctctgg atacgttgca atctgttcgg ttctgcttgt cccctggtgt 60tggctcccgt at 7236372DNAArtificial Sequencechemically synthesized 363atacgggagc caacaccagc gcttgaacaa cataatgccg cccaagacct tgacagagca 60ggtgtgacgg at 7236472DNAArtificial Sequencechemically synthesized 364atccgtcaca cctgctctgt caaggtcttg ggcggcatta tgttgttcaa gcgctggtgt 60tggctcccgt at 7236572DNAArtificial Sequencechemically synthesized 365atacgggagc caacaccaca gtgcctagac ttttacaatg aaccaattgc tggaagagca 60ggtgtgacgg at 7236672DNAArtificial Sequencechemically synthesized 366atccgtcaca cctgctcttc cagcaattgg ttcattgtaa aagtctaggc actgtggtgt 60tggctcccgt at 7236772DNAArtificial Sequencechemically synthesized 367atacgggagc caacaccacc cactctcccc ccgctcccgc tcccccgctc cgcgagagca 60ggtgtgacgg at 7236872DNAArtificial Sequencechemically synthesized 368atccgtcaca cctgctctcg cggagcgggg gagcgggagc ggggggagag tgggtggtgt 60tggctcccgt at 7236972DNAArtificial Sequencechemically synthesized 369atacgggagc caacaccatc taacaatcat acacttggaa ggtgactgtc ctggagagca 60ggtgtgacgg at 7237072DNAArtificial Sequencechemically synthesized 370atccgtcaca cctgctctcc aggacagtca ccttccaagt gtatgattgt tagatggtgt 60tggctcccgt at 7237172DNAArtificial Sequencechemically synthesized 371atacgggagc caacaccatg tcaggacctc catcgcccgg gcccgccgcc gctgagagca 60ggtgtgacgg at 7237272DNAArtificial Sequencechemically synthesized 372atccgtcaca cctgctctca gcggcggcgg gcccgggcga tggaggtcct gacatggtgt 60tggctcccgt at 7237372DNAArtificial Sequencechemically synthesized 373atacgggagc caacaccagg cgacagcctg tgcgagtaag attgaatggt aggtagagca 60ggtgtgacgg at 7237472DNAArtificial Sequencechemically synthesized 374atccgtcaca cctgctctac ctaccattca atcttactcg cacaggctgt cgcctggtgt 60tggctcccgt at 7237572DNAArtificial Sequencechemically synthesized 375atacgggagc caacaccatc tgtgtcagtc tggcctgttt tttattctcc gcggagagca 60ggtgtgacgg at 7237672DNAArtificial Sequencechemically synthesized 376atccgtcaca cctgctctcc gcggagaata aaaaacaggc cagactgaca cagatggtgt 60tggctcccgt at 7237772DNAArtificial Sequencechemically synthesized 377atacgggagc caacaccagc caggaaaact atgaggcaaa aacacgatcc gggtagagca 60ggtgtgacgg at 7237872DNAArtificial Sequencechemically synthesized 378atccgtcaca cctgctctac ccggatcgtg tttttgcctc atagttttcc tggctggtgt 60tggctcccgt at 7237972DNAArtificial Sequencechemically synthesized 379atacgggagc caacaccata gaagtatgtt gttattctat ggaaataaaa cgacagagca 60ggtgtgacgg at 7238072DNAArtificial Sequencechemically synthesized 380atccgtcaca cctgctctgt cgttttattt ccatagaata acaacatact tctatggtgt 60tggctcccgt at 7238172DNAArtificial Sequencechemically synthesized 381atacgggagc caacaccatc ccgttgtgat cagagagcat gaaatgatgt tttgagagca 60ggtgtgacgg at 7238272DNAArtificial Sequencechemically synthesized 382atccgtcaca cctgctctca aaacatcatt tcatgctctc tgatcacaac gggatggtgt 60tggctcccgt at 7238372DNAArtificial Sequencechemically synthesized 383atacgggagc caacaccatg catgggacct gttatcctaa caagctgtca aggcagagca 60ggtgtgacgg at 7238472DNAArtificial Sequencechemically synthesized 384atccgtcaca cctgctctgc cttgacagct tgttaggata acaggtccca tgcatggtgt 60tggctcccgt at 7238571DNAArtificial Sequencechemically synthesized 385atacgggagc caacaccaca aaacgttccg agggagtaag cacttaataa tgtagagcag 60gtgtgacgga t 7138671DNAArtificial Sequencechemically synthesized 386atccgtcaca cctgctctac attattaagt gcttactccc tcggaacgtt ttgtggtgtt 60ggctcccgta t 7138772DNAArtificial Sequencechemically synthesized 387atacgggagc caacaccacg tcttatagat gtctgtattg tttatcgctc gcccagagca 60ggtgtgacgg at 7238872DNAArtificial Sequencechemically synthesized 388atccgtcaca cctgctctgg gcgagcgata aacaatacag acatctataa gacgtggtgt 60tggctcccgt at 7238972DNAArtificial Sequencechemically synthesized 389atacgggagc caacaccacc atctctggtg ataaccagtg atcttaacta tagcagagca 60ggtgtgacgg at 7239072DNAArtificial Sequencechemically synthesized 390atccgtcaca cctgctctgc tatagttaag atcactggtt atcaccagag atggtggtgt 60tggctcccgt at 7239172DNAArtificial Sequencechemically synthesized 391atacgggagc caacaccacc acctcactac agtgatcttt tgctctgaat agccagagca 60ggtgtgacgg at 7239272DNAArtificial Sequencechemically synthesized 392atccgtcaca cctgctctgg ctattcagag caaaagatca ctgtagtgag gtggtggtgt 60tggctcccgt at 7239372DNAArtificial Sequencechemically synthesized 393atacgggagc caacaccatg tctcttagga tacaaagcca aactgagccc gtgcagagca 60ggtgtgacgg at 7239472DNAArtificial Sequencechemically synthesized 394atccgtcaca cctgctctgc acgggctcag tttggctttg tatcctaaga gacatggtgt 60tggctcccgt at 7239572DNAArtificial Sequencechemically synthesized 395atacgggagc caacaccacc tccaatagcc aaaagaaatc gccaactaac ggcaagagca 60ggtgtgacgg at 7239672DNAArtificial Sequencechemically synthesized 396atccgtcaca cctgctcttg ccgttagttg gcgatttctt ttggctattg gaggtggtgt 60tggctcccgt at 7239772DNAArtificial Sequencechemically synthesized 397atacgggagc caacaccatc actactttta taatttcatt cttctggcgt ccctagagca 60ggtgtgacgg at 7239872DNAArtificial Sequencechemically synthesized 398atccgtcaca cctgctctag ggacgccaga agaatgaaat tataaaagta gtgatggtgt 60tggctcccgt at 7239972DNAArtificial Sequencechemically synthesized 399atacgggagc caacaccaac tgcccacgcc gcgaccccgc ggcgcaccca accaagagca 60ggtgtgacgg at 7240072DNAArtificial Sequencechemically synthesized 400atccgtcaca cctgctcttg gttgggtgcg ccgcggggtc gcggcgtggg cagttggtgt 60tggctcccgt at 7240172DNAArtificial Sequencechemically synthesized 401atacgggagc caacaccaac ggttaccagg cgtgttaagg atatatgctg aaccagagca 60ggtgtgacgg at 7240272DNAArtificial Sequencechemically synthesized 402atccgtcaca cctgctctgg ttcagcatat atccttaaca cgcctggtaa ccgttggtgt 60tggctcccgt at 7240358DNAArtificial Sequencechemically synthesized 403atccgtcaca cctgctctgt ccaaaggcta cgcgttaacg tggtgttggc tcccgtat 5840458DNAArtificial Sequencechemically synthesized 404atccgtcaca cctgctctgg agcaatatgg tggagaaacg tggtgttggc tcccgtat 5840559DNAArtificial Sequencechemically synthesized 405atccgtcaca cctgctctgc cggaccatcc aatatcagct gtggtgttgg ctcccgtat 5940672DNAArtificial Sequencechemically synthesized 406atccgtcaca cctgctctga acaggatagg gattagcgag tcaactaagc agcatggtgt 60tggctcccgt at 7240772DNAArtificial Sequencechemically synthesized 407atccgtcaca cctgctctgg cggacaggaa ataagaatga acgcaaaatt tatctggtgt 60tggctcccgt at 7240872DNAArtificial Sequencechemically synthesized 408atccgtcaca cctgctctac gcaacgcgac aggaacattc attatagaat gtgttggtgt 60tggctcccgt at 7240972DNAArtificial Sequencechemically synthesized 409atccgtcaca cctgctctcg gctgcaatgc gggagagtag gggggaacca aacctggtgt 60tggctcccgt at 7241072DNAArtificial Sequencechemically synthesized 410atccgtcaca cctgctctat gactggaaca cgggtatcga tgattagatg tccttggtgt 60tggctcccgt at 7241158DNAArtificial Sequencechemically synthesized 411atacgggagc caacaccacg ttaacgcgta gcctttggac agagcaggtg tgacggat 5841258DNAArtificial Sequencechemically synthesized 412atacgggagc caacaccacg tttctccacc atattgctcc agagcaggtg tgacggat 5841359DNAArtificial Sequencechemically synthesized 413atacgggagc caacaccaca gctgatattg gatggtccgg cagagcaggt gtgacggat 5941472DNAArtificial Sequencechemically synthesized 414atacgggagc caacaccatg ctgcttagtt gactcgctaa tccctatcct gttcagagca 60ggtgtgacgg at 7241572DNAArtificial Sequencechemically synthesized 415atacgggagc caacaccaga taaattttgc gttcattctt atttcctgtc cgccagagca 60ggtgtgacgg at 7241672DNAArtificial Sequencechemically synthesized 416atacgggagc caacaccaac acattctata atgaatgttc ctgtcgcgtt gcgtagagca 60ggtgtgacgg at 7241772DNAArtificial Sequencechemically synthesized 417atacgggagc caacaccagg tttggttccc ccctactctc ccgcattgca gccgagagca 60ggtgtgacgg at 7241872DNAArtificial Sequencechemically synthesized 418atacgggagc caacaccaag gacatctaat catcgatacc cgtgttccag tcatagagca 60ggtgtgacgg at 7241972DNAArtificial Sequencechemically synthesized 419atacgggagc caacaccaga taaattttgc gttcattctt atttcctgtc cgccagagca 60ggtgtgacgg at 7242072DNAArtificial Sequencechemically synthesized 420atccgtcaca cctgctctgg cggacaggaa ataagaatga acgcaaaatt tatctggtgt 60tggctcccgt at 7242171DNAArtificial Sequencechemically synthesized 421atacgggagc caacaccaga taaattttgg ttcattctta tttcctgtcc gccagagcag 60gtgtgacgga t 7142271DNAArtificial Sequencechemically synthesized 422atccgtcaca cctgctctgg cggacaggaa ataagaatga accaaaattt atctggtgtt 60ggctcccgta t 7142372DNAArtificial Sequencechemically synthesized 423atacgggagc caacaccacg gggctaccag caccgtcacc cctcattctg ccacagagca 60ggtgtgacgg at 7242472DNAArtificial Sequencechemically synthesized 424atccgtcaca cctgctctgt ggcagaatga ggggtgacgg tgctggtagc cccgtggtgt 60tggctcccgt at 7242569DNAArtificial Sequencechemically synthesized 425atacgggagc

caacaccaaa agatggaaaa cactggaagg aaaatgcggt cagagcaggt 60gtgacggat 6942669DNAArtificial Sequencechemically synthesized 426atccgtcaca cctgctctga ccgcattttc cttccagtgt tttccatctt ttggtgttgg 60ctcccgtat 6942772DNAArtificial Sequencechemically synthesized 427atacgggagc caacaccacc gggccgatgg gcaccaggaa ctctcggacg agtgagagca 60ggtgtgacgg at 7242872DNAArtificial Sequencechemically synthesized 428atccgtcaca cctgctctca ctcgtccgag agttcctggt gcccatcggc ccggtggtgt 60tggctcccgt at 7242959DNAArtificial Sequencechemically synthesized 429atacgggagc caacaccaca gctgatattg gatggtccgg cagagcaggt gtgacggat 5943059DNAArtificial Sequencechemically synthesized 430atccgtcaca cctgctctgc cggaccatcc aatatcagct gtggtgttgg ctcccgtat 5943172DNAArtificial Sequencechemically synthesized 431atacgggagc caacaccagt cgaaaggcgg ccgtccagtc gagtgatttg acctagagca 60ggtgtgacgg at 7243272DNAArtificial Sequencechemically synthesized 432atccgtcaca cctgctctag gtcaaatcac tcgactggac ggccgccttt cgactggtgt 60tggctcccgt at 7243372DNAArtificial Sequencechemically synthesized 433atacgggagc caacaccacg gggcgtgccg tcaaaagacc gagatgtggc tgcgagagca 60ggtgtgacgg at 7243472DNAArtificial Sequencechemically synthesized 434atccgtcaca cctgctctcg cagccacatc tcggtctttt gacggcacgc cccgtggtgt 60tggctcccgt at 7243559DNAArtificial Sequencechemically synthesized 435atacgggagc caacaccact aacttgttgc tgatcttatc cagagcaggt gtgacggat 5943659DNAArtificial Sequencechemically synthesized 436atccgtcaca cctgctctgg ataagatcag caacaagtta gtggtgttgg ctcccgtat 5943772DNAArtificial Sequencechemically synthesized 437atacgggagc caacaccatt tagcgtaggg ctcgcttatc atttctcatt ccctagagca 60ggtgtgacgg at 7243872DNAArtificial Sequencechemically synthesized 438atccgtcaca cctgctctag ggaatgagaa atgataagcg agccctacgc taaatggtgt 60tggctcccgt at 7243972DNAArtificial Sequencechemically synthesized 439atacgggagc caacaccacc gcaacccaaa tctctacacg gattatcgtc gagcagagca 60ggtgtgacgg at 7244072DNAArtificial Sequencechemically synthesized 440atccgtcaca cctgctctgc tcgacgataa tccgtgtaga gatttgggtt gcggtggtgt 60tggctcccgt at 7244172DNAArtificial Sequencechemically synthesized 441atacgggagc caacaccaac acattctata atgaatgttc ctgtcgcgtt gcgtagagca 60ggtgtgacgg at 7244272DNAArtificial Sequencechemically synthesized 442atccgtcaca cctgctctac gcaacgcgac aggaacattc attatagaat gtgttggtgt 60tggctcccgt at 7244372DNAArtificial Sequencechemically synthesized 443atacgggagc caacaccagc ctaccccccc tgtacgaggg ccgcaaccac gtagagagca 60ggtgtgacgg at 7244472DNAArtificial Sequencechemically synthesized 444atccgtcaca cctgctctct acgtggttgc ggccctcgta cagggggggt aggctggtgt 60tggctcccgt at 7244559DNAArtificial Sequencechemically synthesized 445atacgggagc caacaccaca tctagcacga gaccctatcc cagagcaggt gtgacggat 5944659DNAArtificial Sequencechemically synthesized 446atccgtcaca cctgctctgg gatagggtct cgtgctagat gtggtgttgg ctcccgtat 5944772DNAArtificial Sequencechemically synthesized 447atacgggagc caacaccaac agcgactcga gtctgacgac tcgcggggca aatgagagca 60ggtgtgacgg at 7244872DNAArtificial Sequencechemically synthesized 448atccgtcaca cctgctctca tttgccccgc gagtcgtcag actcgagtcg ctgttggtgt 60tggctcccgt at 7244969DNAArtificial Sequencechemically synthesized 449atacgggagc caacaccata gtgttgggcc aatacggtaa cgtgtccttg gagagcaggt 60gtgacggat 6945069DNAArtificial Sequencechemically synthesized 450atccgtcaca cctgctctcc aaggacacgt taccgtattg gcccaacact atggtgttgg 60ctcccgtat 6945172DNAArtificial Sequencechemically synthesized 451atacgggagc caacaccact aaggagaggt cgcgacagac tcttctggtc aaggagagca 60ggtgtgacgg at 7245273DNAArtificial Sequencechemically synthesized 452atccgtcaca cctgctctcc ttgaccagaa gagtctgtcg cgacctctcc ttagtggtgt 60tggctcccgt atg 7345372DNAArtificial Sequencechemically synthesized 453atacgggagc caacaccaac ttcgactcaa agaagtccac gtgagactgg tggaagagca 60ggtgtgacgg at 7245472DNAArtificial Sequencechemically synthesized 454atccgtcaca cctgctcttc caccagtctc acgtggactt ctttgagtcg aagttggtgt 60tggctcccgt at 7245572DNAArtificial Sequencechemically synthesized 455atacgggagc caacaccacc cggggagacc cgcacgggcg cacaatcctt gtcgagagca 60ggtgtgacgg at 7245672DNAArtificial Sequencechemically synthesized 456atccgtcaca cctgctctcg acaaggattg tgcgcccgtg cgggtctccc cgggtggtgt 60tggctcccgt at 7245772DNAArtificial Sequencechemically synthesized 457atacgggagc caacaccagc tggaccaaac tacgcccatt gtgggggtcc ccggagagca 60ggtgtgacgg at 7245872DNAArtificial Sequencechemically synthesized 458atccgtcaca cctgctctcc ggggaccccc acaatgggcg tagtttggtc cagctggtgt 60tggctcccgt at 7245969DNAArtificial Sequencechemically synthesized 459atacgggagc caacaccata gtgttgggcc aatacggtaa cgtgtccttg gagagcaggt 60gtgacggat 6946069DNAArtificial Sequencechemically synthesized 460atccgtcaca cctgctctcc aaggacacgt taccgtattg gcccaacact atggtgttgg 60ctcccgtat 6946172DNAArtificial Sequencechemically synthesized 461atacgggagc caacaccagt gggacctacg gcctttggcc cgctgttaca acgtagagca 60ggtgtgacgg at 7246272DNAArtificial Sequencechemically synthesized 462atccgtcaca cctgctctac gttgtaacag cgggccaaag gccgtaggtc ccactggtgt 60tggctcccgt at 7246372DNAArtificial Sequencechemically synthesized 463atacgggagc caacaccact tacgcatcag ccactcgaga gacggcgtta tggcagagca 60ggtgtgacgg at 7246472DNAArtificial Sequencechemically synthesized 464atccgtcaca cctgctctgc cataacgccg tctctcgagt ggctgatgcg taagtggtgt 60tggctcccgt at 7246572DNAArtificial Sequencechemically synthesized 465atacgggagc caacaccact atagggtgta gctgatccgc tcccttctcc caggagagca 60ggtgtgacgg at 7246672DNAArtificial Sequencechemically synthesized 466atccgtcaca cctgctctcc tgggagaagg gagcggatca gctacaccct atagtggtgt 60tggctcccgt at 7246772DNAArtificial Sequencechemically synthesized 467atacgggagc caacaccaga acacctagag actagttcgt gtcggcccag cgtgagagca 60ggtgtgacgg at 7246872DNAArtificial Sequencechemically synthesized 468atccgtcaca cctgctctca cgctgggccg acacgaacta gtctctaggt gttctggtgt 60tggctcccgt at 7246972DNAArtificial Sequencechemically synthesized 469atacgggagc caacaccata agaaccacca ttccgcgttc gcctcccgag gtgtagagca 60ggtgtgacgg at 7247072DNAArtificial Sequencechemically synthesized 470atccgtcaca cctgctctac acctcgggag gcgaacgcgg aatggtggtt cttatggtgt 60tggctcccgt at 7247172DNAArtificial Sequencechemically synthesized 471atacgggagc caacaccagg ccataggcaa tttcatatag caactggtga gcgtagagca 60ggtgtgacgg at 7247272DNAArtificial Sequencechemically synthesized 472atccgtcaca cctgctctac gctcaccagt tgctatatga aattgcctat ggcctggtgt 60tggctcccgt at 7247372DNAArtificial Sequencechemically synthesized 473atacgggagc caacaccaac agaagtcgac cctggtaatc atgctctctc acggagagca 60ggtgtgacgg at 7247472DNAArtificial Sequencechemically synthesized 474atccgtcaca cctgctctcc gtgagagagc atgattacca gggtcgactt ctgttggtgt 60tggctcccgt at 7247572DNAArtificial Sequencechemically synthesized 475atacgggagc caacaccacc aacacctgga gaacttgaaa cgcagatggt ccccagagca 60ggtgtgacgg at 7247672DNAArtificial Sequencechemically synthesized 476atccgtcaca cctgctctgg ggaccatctg cgtttcaagt tctccaggtg ttggtggtgt 60tggctcccgt at 7247772DNAArtificial Sequencechemically synthesized 477atacgggagc caacaccagg tagcgacatg acagtaccac ttacaggacg tgccagagca 60ggtgtgacgg at 7247872DNAArtificial Sequencechemically synthesized 478atccgtcaca cctgctctgg cacgtcctgt aagtggtact gtcatgtcgc tacctggtgt 60tggctcccgt at 7247972DNAArtificial Sequencechemically synthesized 479atacgggagc caacaccaat gacgtaaaca caaacggcgg acccaatcgt gttcagagca 60ggtgtgacgg at 7248072DNAArtificial Sequencechemically synthesized 480atccgtcaca cctgctctga acacgattgg gtccgccgtt tgtgtttacg tcattggtgt 60tggctcccgt at 7248172DNAArtificial Sequencechemically synthesized 481atacgggagc caacaccatg ctccagcata ttgattaatg ccaagagttg gaacagagca 60ggtgtgacgg at 7248272DNAArtificial Sequencechemically synthesized 482atccgtcaca cctgctctgt tccaactctt ggcattaatc aatatgctgg agcatggtgt 60tggctcccgt at 7248372DNAArtificial Sequencechemically synthesized 483atacgggagc caacaccatg tggttcagat gcgccatatc tagacggtct ctgtagagca 60ggtgtgacgg at 7248472DNAArtificial Sequencechemically synthesized 484atccgtcaca cctgctctac agagaccgtc tagatatggc gcatctgaac cacatggtgt 60tggctcccgt at 7248572DNAArtificial Sequencechemically synthesized 485atacgggagc caacaccaaa ccccattctg tcacagcgcc acccaacgag tgttagagca 60ggtgtgacgg at 7248672DNAArtificial Sequencechemically synthesized 486atccgtcaca cctgctctaa cactcgttgg gtggcgctgt gacagaatgg ggtttggtgt 60tggctcccgt at 7248772DNAArtificial Sequencechemically synthesized 487atacgggagc caacaccagc cggtatcggt gctgagggcc ttggcttggc tctgagagca 60ggtgtgacgg at 7248872DNAArtificial Sequencechemically synthesized 488atccgtcaca cctgctctca gagccaagcc aaggccctca gcaccgatac cggctggtgt 60tggctcccgt at 7248972DNAArtificial Sequencechemically synthesized 489atacgggagc caacaccatg gcgacctaat cagccggaca gtgctcctca acgtagagca 60ggtgtgacgg at 7249072DNAArtificial Sequencechemically synthesized 490atccgtcaca cctgctctac gttgaggagc actgtccggc tgattaggtc gccatggtgt 60tggctcccgt at 7249171DNAArtificial Sequencechemically synthesized 491atacgggagc caacaccatg gagacagggg gaacgacagc ggcggttgcg gggcagagca 60ggtgtgacgg a 7149272DNAArtificial Sequencechemically synthesized 492atccgtcaca cctgctctgc cccgcaaccg ccgctgtcgt tccccctgtc tccatggtgt 60tggctcccgt at 7249372DNAArtificial Sequencechemically synthesized 493atacgggagc caacaccaat agccggccga aatccctttg ggatggtcat accgagagca 60ggtgtgacgg at 7249472DNAArtificial Sequencechemically synthesized 494atccgtcaca cctgctctcg gtatgaccat cccaaaggga tttcggccgg ctattggtgt 60tggctcccgt at 7249572DNAArtificial Sequencechemically synthesized 495atacgggagc caacaccacc gaatgtgctg caagactaat ctggatggcc atgcagagca 60ggtgtgacgg at 7249672DNAArtificial Sequencechemically synthesized 496atccgtcaca cctgctctgc atggccatcc agattagtct tgcagcacat tcggtggtgt 60tggctcccgt at 7249772DNAArtificial Sequencechemically synthesized 497atacgggagc caacaccaaa tcgagttcgt gacagttggg cagataccga gtccagagca 60ggtgtgacgg at 7249872DNAArtificial Sequencechemically synthesized 498atccgtcaca cctgctctgg actcggtatc tgcccaactg tcacgaactc gatttggtgt 60tggctcccgt at 7249972DNAArtificial Sequencechemically synthesized 499atacgggagc caacaccagg gtccacgcta cacggatcaa gtctagctgg ttgtagagca 60ggtgtgacgg at 7250072DNAArtificial Sequencechemically synthesized 500atccgtcaca cctgctctac aaccagctag acttgatccg tgtagcgtgg accctggtgt 60tggctcccgt at 7250172DNAArtificial Sequencechemically synthesized 501atacgggagc caacaccatc ccacaaggct cgtgttaggc ctccaatgct ctcgagagca 60ggtgtgacgg at 7250272DNAArtificial Sequencechemically synthesized 502atccgtcaca cctgctctcg agagcattgg aggcctaaca cgagccttgt gggatggtgt 60tggctcccgt at 7250372DNAArtificial Sequencechemically synthesized 503atacgggagc caacaccagg ccccgagaaa ttatcgatag tggtttctcg ccctagagca 60ggtgtgacgg at 7250472DNAArtificial Sequencechemically synthesized 504atccgtcaca cctgctctag ggcgagaaac cactatcgat aatttctcgg ggcctggtgt 60tggctcccgt at 7250572DNAArtificial Sequencechemically synthesized 505atacgggagc caacaccaca cccggatgcg attaagaagt tactgccttg cgggagagca 60ggtgtgacgg at 7250672DNAArtificial Sequencechemically synthesized 506atccgtcaca cctgctctcc cgcaaggcag taacttctta atcgcatccg ggtgtggtgt 60tggctcccgt at 7250772DNAArtificial Sequencechemically synthesized 507atacgggagc caacaccatg ccatgcactt ggttccgaac gttcgcgtca ttgcagagca 60ggtgtgacgg at 7250872DNAArtificial Sequencechemically synthesized 508atccgtcaca cctgctctgc aatgacgcga acgttcggaa ccaagtgcat ggcatggtgt 60tggctcccgt at 7250972DNAArtificial Sequencechemically synthesized 509atacgggagc caacaccacc aaaaaaagct gtgaccggaa ggtgctgctg acgtagagca 60ggtgtgacgg at 7251072DNAArtificial Sequencechemically synthesized 510atccgtcaca cctgctctac gtcagcagca ccttccggtc acagcttttt ttggtggtgt 60tggctcccgt at

7251172DNAArtificial Sequencechemically synthesized 511atacgggagc caacaccaag ctaccatcca cctaacagga ctacgcgaat tgcaagagca 60ggtgtgacgg at 7251272DNAArtificial Sequencechemically synthesized 512atccgtcaca cctgctcttg caattcgcgt agtcctgtta ggtggatggt agcttggtgt 60tggctcccgt at 7251359DNAArtificial Sequencechemically synthesized 513atacgggagc caacaccaca agcaggaata agcgccggtc cagagcaggt gtgacggat 5951459DNAArtificial Sequencechemically synthesized 514atccgtcaca cctgctctgg accggcgctt attcctgctt gtggtgttgg ctcccgtat 5951572DNAArtificial Sequencechemically synthesized 515atacgggagc caacaccaca tggaccggca acctcagaag tagcaaacca ccatagagca 60ggtgtgacgg at 7251672DNAArtificial Sequencechemically synthesized 516atccgtcaca cctgctctat ggtggtttgc tacttctgag gttgccggtc catgtggtgt 60tggctcccgt at 7251772DNAArtificial Sequencechemically synthesized 517atacgggagc caacaccatg tccaaaccat tctcggacct ccctcagtgg cggcagagca 60ggtgtgacgg at 7251872DNAArtificial Sequencechemically synthesized 518atccgtcaca cctgctctgc cgccactgag ggaggtccga gaatggtttg gacatggtgt 60tggctcccgt at 7251972DNAArtificial Sequencechemically synthesized 519atacgggagc caacaccagt ccgttatgac atgtccggac ccgtacgcgt gtcaagagca 60ggtgtgacgg at 7252072DNAArtificial Sequencechemically synthesized 520atccgtcaca cctgctcttg acacgcgtac gggtccggac atgtcataac ggactggtgt 60tggctcccgt at 7252172DNAArtificial Sequencechemically synthesized 521atacgggagc caacaccatc cgctcacatg atgctgtacg atggccgcgt gcaaagagca 60ggtgtgacgg at 7252272DNAArtificial Sequencechemically synthesized 522atccgtcaca cctgctcttt gcacgcggcc atcgtacagc atcatgtgag cggatggtgt 60tggctcccgt at 7252371DNAArtificial Sequencechemically synthesized 523atacgggagc caacaccacg tcgcatatac cccgagaagg tagatcgtgg actagagcag 60gtgtgacgga t 7152471DNAArtificial Sequencechemically synthesized 524atccgtcaca cctgctctag tccacgatct accttctcgg ggtatatgcg acgtggtgtt 60ggctcccgta t 7152571DNAArtificial Sequencechemically synthesized 525atacgggagc caacaccacg aggacctaga cttgtccgac atcacagtgt gcgagagcag 60gtgtgacgga t 7152671DNAArtificial Sequencechemically synthesized 526atccgtcaca cctgctctcg cacactgtga tgtcggacaa gtctaggtcc tcgtggtgtt 60ggctcccgta t 7152759DNAArtificial Sequencechemically synthesized 527atacgggagc caacaccaca gctgatattg gatggtccgg cagagcaggt gtgacggat 5952859DNAArtificial Sequencechemically synthesized 528atccgtcaca cctgctctgc cggaccatcc aatatcagct gtggtgttgg ctcccgtat 5952972DNAArtificial Sequencechemically synthesized 529atacgggagc caacaccacg ggaccatcag cctcaacttc ctacaaggcc tactagagca 60ggtgtgacgg at 7253072DNAArtificial Sequencechemically synthesized 530atccgtcaca cctgctctag taggccttgt aggaagttga ggctgatggt cccgtggtgt 60tggctcccgt at 7253172DNAArtificial Sequencechemically synthesized 531atacgggagc caacaccaat ggacaaaggc aatagcgtca attgaagtca gaccagagca 60ggtgtgacgg at 7253272DNAArtificial Sequencechemically synthesized 532atccgtcaca cctgctctgg tctgacttca attgacgcta ttgcctttgt ccattggtgt 60tggctcccgt at 7253372DNAArtificial Sequencechemically synthesized 533atacgggagc caacaccaac tgaactcatg aagcacgatt gttgccccac gtgcagagca 60ggtgtgacgg at 7253472DNAArtificial Sequencechemically synthesized 534atccgtcaca cctgctctgc acgtggggca acaatcgtgc ttcatgagtt cagttggtgt 60tggctcccgt at 7253572DNAArtificial Sequencechemically synthesized 535atacgggagc caacaccaat ccctagcaag taagctggtg gagctagtac acgtagagca 60ggtgtgacgg at 7253672DNAArtificial Sequencechemically synthesized 536atccgtcaca cctgctctac gtgtactagc tccaccagct tacttgctag ggattggtgt 60tggctcccgt at 7253772DNAArtificial Sequencechemically synthesized 537atacgggagc caacaccaca ccgaaagccg gaacgatagg gtacagctgg gtgtagagca 60ggtgtgacgg at 7253872DNAArtificial Sequencechemically synthesized 538atccgtcaca cctgctctac acccagctgt accctatcgt tccggctttc ggtgtggtgt 60tggctcccgt at 7253972DNAArtificial Sequencechemically synthesized 539atacgggagc caacaccaag ggcgaactag catcacctcg gtcgctcata ggccagagca 60ggtgtgacgg at 7254072DNAArtificial Sequencechemically synthesized 540atccgtcaca cctgctctgg cctatgagcg accgaggtga tgctagttcg cccttggtgt 60tggctcccgt at 7254171DNAArtificial Sequencechemically synthesized 541atacgggagc caacaccaca gggcgacgta agctccgtcc agaggatgtc agtagagcag 60gtgtgacgga t 7154271DNAArtificial Sequencechemically synthesized 542atccgtcaca cctgctctac tgacatcctc tggacggagc ttacgtcgcc ctgtggtgtt 60ggctcccgta t 7154372DNAArtificial Sequencechemically synthesized 543atccgtcaca cctgctctgg agacattaaa aaccggagtt tatttatacc tttctggtgt 60tggctcccgt at 7254472DNAArtificial Sequencechemically synthesized 544atacgggagc caacaccaga aaggtataaa taaactccgg tttttaatgt ctccagagca 60ggtgtgacgg at 7254559DNAArtificial Sequencechemically synthesized 545atacgggagc caacaccact aacttgttgc tgatcttatc cagagcaggt gtgacggat 5954659DNAArtificial Sequencechemically synthesized 546atccgtcaca cctgctctgg ataagatcag caacaagtta gtggtgttgg ctcccgtat 5954758DNAArtificial Sequencechemically synthesized 547atccgtcaca cctgctctgc atggagagtt ttttggtcag tggtgttggc tcccgtat 5854858DNAArtificial Sequencechemically synthesized 548atacgggagc caacaccact gaccaaaaaa ctctccatgc agagcaggtg tgacggat 5854958DNAArtificial Sequencechemically synthesized 549atacgggagc caacaccacg ttaacgcgta gcctttggac agagcaggtg tgacggat 5855058DNAArtificial Sequencechemically synthesized 550atccgtcaca cctgctctgt ccaaaggcta cgcgttaacg tggtgttggc tcccgtat 5855159DNAArtificial Sequencechemically synthesized 551atccgtcaca cctgctctgc cggaccatcc aatatcagct gtggtgttgg ctcccgtat 5955259DNAArtificial Sequencechemically synthesized 552atacgggagc caacaccaca gctgatattg gatggtccgg cagagcaggt gtgacggat 5955372DNAArtificial Sequencechemically synthesized 553atccgtcaca cctgctctcg tccgtcatta agttcggagg ctggcgggtt gcgttggtgt 60tggctcccgt at 7255472DNAArtificial Sequencechemically synthesized 554atacgggagc caacaccaac gcaacccgcc agcctccgaa cttaatgacg gacgagagca 60ggtgtgacgg at 7255572DNAArtificial Sequencechemically synthesized 555atacgggagc caacaccatt ctatcgttcc ggacgcttat gccttgccat ctacagagca 60ggtgtgacgg at 7255672DNAArtificial Sequencechemically synthesized 556atccgtcaca cctgctctgt agatggcaag gcataagcgt ccggaacgat agaatggtgt 60tggctcccgt at 7255772DNAArtificial Sequencechemically synthesized 557atccgtcaca cctgctctaa ctcttactac tttgttgcta tcacattcaa ctgttggtgt 60tggctcccgt at 7255872DNAArtificial Sequencechemically synthesized 558atacgggagc caacaccaac agttgaatgt gatagcaaca aagtagtaag agttagagca 60ggtgtgacgg at 7255958DNAArtificial Sequencechemically synthesized 559atccgtcaca cctgctctgg cctttcacca agcgtccttg tggtgttggc tcccgtat 5856058DNAArtificial Sequencechemically synthesized 560atacgggagc caacaccaca aggacgcttg gtgaaaggcc agagcaggtg tgacggat 5856158DNAArtificial Sequencechemically synthesized 561atccgtcaca cctgctctgg caccgagcac gggaacccag tggtgttggc tcccgtat 5856258DNAArtificial Sequencechemically synthesized 562atacgggagc caacaccact gggttcccgt gctcggtgcc agagcaggtg tgacggat 5856369DNAArtificial Sequencechemically synthesized 563atacgggagc caacaccata gtgttgggcc aatacggtaa cgtgtccttg gagagcaggt 60gtgacggat 6956469DNAArtificial Sequencechemically synthesized 564atccgtcaca cctgctctcc aaggacacgt taccgtattg gcccaacact atggtgttgg 60ctcccgtat 6956572DNAArtificial Sequencechemically synthesized 565atccgtcaca cctgctctac ccgatgccgc cccgggattg ttgtatgacc atcttggtgt 60tggctcccgt at 7256672DNAArtificial Sequencechemically synthesized 566atacgggagc caacaccaag atggtcatac aacaatcccg gggcggcatc gggtagagca 60ggtgtgacgg at 7256772DNAArtificial Sequencechemically synthesized 567atacgggagc caacaccacc ccatgagtac acgtgaacgg acacagcctc cggcagagca 60ggtgtgacgg at 7256872DNAArtificial Sequencechemically synthesized 568atccgtcaca cctgctctgc cggaggctgt gtccgttcac gtgtactcat ggggtggtgt 60tggctcccgt at 7256972DNAArtificial Sequencechemically synthesized 569atccgtcaca cctgctctta accattcatt tcttttgtgg tatgaccgtt cgcctggtgt 60tggctcccgt at 7257072DNAArtificial Sequencechemically synthesized 570atacgggagc caacaccagg cgaacggtca taccacaaaa gaaatgaatg gttaagagca 60ggtgtgacgg at 7257158DNAArtificial Sequencechemically synthesized 571atccgtcaca cctgctctgg ggctcttttc gttaaccagg tggtgttggc tcccgtat 5857258DNAArtificial Sequencechemically synthesized 572atacgggagc caacaccacc tggttaacga aaagagcccc agagcaggtg tgacggat 5857372DNAArtificial Sequencechemically synthesized 573atacgggagc caacaccagg cgaccaagtt tgaatcacca caatcgtgac ggtgagagca 60ggtgtgacgg at 7257472DNAArtificial Sequencechemically synthesized 574atccgtcaca cctgctctca ccgtcacgat tgtggtgatt caaacttggt cgcctggtgt 60tggctcccgt at 7257572DNAArtificial Sequencechemically synthesized 575atacgggagc caacaccacc atcacatctt ggcccggtac cctggatact agccagagca 60ggtgtgacgg at 7257672DNAArtificial Sequencechemically synthesized 576atccgtcaca cctgctctgg ctagtatcca gggtaccggg ccaagatgtg atggtggtgt 60tggctcccgt at 7257772DNAArtificial Sequencechemically synthesized 577atacgggagc caacaccagc actagctcgg gtaacgggga cattagagtt tgccagagca 60ggtgtgacgg at 7257872DNAArtificial Sequencechemically synthesized 578atccgtcaca cctgctctgg caaactctaa tgtccccgtt acccgagcta gtgctggtgt 60tggctcccgt at 7257972DNAArtificial Sequencechemically synthesized 579atacgggagc caacaccaaa gcccaccgcg cccagatcta caagacttcc aactagagca 60ggtgtgacgg at 7258072DNAArtificial Sequencechemically synthesized 580atccgtcaca cctgctctag ttggaagtct tgtagatctg ggcgcggtgg gctttggtgt 60tggctcccgt at 7258172DNAArtificial Sequencechemically synthesized 581atacgggagc caacaccatc tttgtcactc tggattaggt taatccactg aaacagagca 60ggtgtgacgg at 7258272DNAArtificial Sequencechemically synthesized 582atccgtcaca cctgctctgt ttcagtggat taacctaatc cagagtgaca aagatggtgt 60tggctcccgt at 7258372DNAArtificial Sequencechemically synthesized 583atacgggagc caacaccacg aacccgggat tctagcaatt gtccccctcg agcgagagca 60ggtgtgacgg at 7258472DNAArtificial Sequencechemically synthesized 584atccgtcaca cctgctctcg ctcgaggggg acaattgcta gaatcccggg ttcgtggtgt 60tggctcccgt at 7258572DNAArtificial Sequencechemically synthesized 585atacgggagc caacaccaat gattaataga accccctatg acctggccgc tgggagagca 60ggtgtgacgg at 7258672DNAArtificial Sequencechemically synthesized 586atccgtcaca cctgctctcc cagcggccag gtcatagggg gttctattaa tcattggtgt 60tggctcccgt at 7258772DNAArtificial Sequencechemically synthesized 587atacgggagc caacaccatg gtcggatagc atgtccatgt tgtcgggttt aacaagagca 60ggtgtgacgg at 7258872DNAArtificial Sequencechemically synthesized 588atccgtcaca cctgctcttg ttaaacccga caacatggac atgctatccg accatggtgt 60tggctcccgt at 7258972DNAArtificial Sequencechemically synthesized 589atacgggagc caacaccagg ggaatcttgc ttgcgtagcg acgcataatg acgtagagca 60ggtgtgacgg at 7259072DNAArtificial Sequencechemically synthesized 590atccgtcaca cctgctctac gtcattatgc gtcgctacgc aagcaagatt cccctggtgt 60tggctcccgt at 7259172DNAArtificial Sequencechemically synthesized 591atacgggagc caacaccatg aagtggacaa atgtgcgttc ccctgacgta ccggagagca 60ggtgtgacgg at 7259271DNAArtificial Sequencechemically synthesized 592atccgtcaca cctgctctcc ggtacgtcag gggaacgcac atttgtccac ttcatggtgt 60tggctcccgt a 7159372DNAArtificial Sequencechemically synthesized 593atacgggagc caacaccacc atttagtgtt agactaagtg atatcgagtc gaggagagca 60ggtgtgacgg at 7259472DNAArtificial Sequencechemically synthesized 594atccgtcaca cctgctctcc tcgactcgat atcacttagt ctaacactaa atggtggtgt 60tggctcccgt at 7259572DNAArtificial Sequencechemically synthesized 595atacgggagc caacaccact tccacttttt cgcctaattg cctgttgcat ggtaagagca 60ggtgtgacgg at 7259672DNAArtificial Sequencechemically synthesized 596atccgtcaca cctgctctta ccatgcaaca ggcaattagg cgaaaaagtg gaagtggtgt 60tggctcccgt at 7259772DNAArtificial Sequencechemically synthesized 597atacgggagc caacaccagg cgatgtccta aagtctttaa ggcgaatata gttgagagca 60ggtgtgacgg at 7259872DNAArtificial Sequencechemically synthesized 598atccgtcaca cctgctctca actatattcg ccttaaagac tttaggacat cgcctggtgt 60tggctcccgt at 7259972DNAArtificial Sequencechemically synthesized 599atacgggagc caacaccacc cccccctccg tgggccgctc ccctcggccg ggccagagca 60ggtgtgacgg at 7260072DNAArtificial Sequencechemically synthesized 600atccgtcaca cctgctctgg cccggccgag gggagcggcc cacggagggg ggggtggtgt 60tggctcccgt

at 7260172DNAArtificial Sequencechemically synthesized 601atacgggagc caacaccatc ccgtgaagca acgacaatac aagacgagcg aaggagagca 60ggtgtgacgg at 7260272DNAArtificial Sequencechemically synthesized 602atccgtcaca cctgctctcc ttcgctcgtc ttgtattgtc gttgcttcac gggatggtgt 60tggctcccgt at 7260372DNAArtificial Sequencechemically synthesized 603atacgggagc caacaccacg cgacttcttc aacagataca gagcgcttgg ggccagagca 60ggtgtgacgg at 7260472DNAArtificial Sequencechemically synthesized 604atccgtcaca cctgctctgg ccccaagcgc tctgtatctg ttgaagaagt cgcgtggtgt 60tggctcccgt at 7260572DNAArtificial Sequencechemically synthesized 605atacgggagc caacaccagg aaatggtacc taagaaatga gaactttgac gcacagagca 60ggtgtgacgg at 7260672DNAArtificial Sequencechemically synthesized 606atccgtcaca cctgctctgt gcgtcaaagt tctcatttct taggtaccat ttcctggtgt 60tggctcccgt at 7260772DNAArtificial Sequencechemically synthesized 607atacgggagc caacaccatt aaagttaatc ttacacgttt ccgacttcca tttgagagca 60ggtgtgacgg at 7260872DNAArtificial Sequencechemically synthesized 608atccgtcaca cctgctctca aatggaagtc ggaaacgtgt aagattaact ttaatggtgt 60tggctcccgt at 7260972DNAArtificial Sequencechemically synthesized 609atacgggagc caacaccaag gagtccgtct acgttttacg agctaaggcc tttgagagca 60ggtgtgacgg at 7261072DNAArtificial Sequencechemically synthesized 610atccgtcaca cctgctctca aaggccttag ctcgtaaaac gtagacggac tccttggtgt 60tggctcccgt at 7261172DNAArtificial Sequencechemically synthesized 611atacgggagc caacaccata atgaagcgat gtagcgagtt tttgaaaggg acacagagca 60ggtgtgacgg at 7261272DNAArtificial Sequencechemically synthesized 612atccgtcaca cctgctctgt gtccctttca aaaactcgct acatcgcttc attatggtgt 60tggctcccgt at 7261372DNAArtificial Sequencechemically synthesized 613atacgggagc caacaccatt tagtccatag cttcagcgct tccacctcct taacagagca 60ggtgtgacgg at 7261472DNAArtificial Sequencechemically synthesized 614atccgtcaca cctgctctgt taaggaggtg gaagcgctga agctatggac taaatggtgt 60tggctcccgt at 7261572DNAArtificial Sequencechemically synthesized 615atacgggagc caacaccacc cgtttttgat ctaatgagga tacaatattc gtctagagca 60ggtgtgacgg at 7261672DNAArtificial Sequencechemically synthesized 616atccgtcaca cctgctctag acgaatattg tatcctcatt agatcaaaaa cgggtggtgt 60tggctcccgt at 7261772DNAArtificial Sequencechemically synthesized 617atacgggagc caacaccacc gggtccccgt gatctaggac aacacggcgg ttggagagca 60ggtgtgacgg at 7261872DNAArtificial Sequencechemically synthesized 618atccgtcaca cctgctctcc aaccgccgtg ttgtcctaga tcacggggac ccggtggtgt 60tggctcccgt at 7261972DNAArtificial Sequencechemically synthesized 619atacgggagc caacaccagt tcaggcatac atgatgtggg ttcttattcc gtgcagagca 60ggtgtgacgg at 7262072DNAArtificial Sequencechemically synthesized 620atccgtcaca cctgctctgc acggaataag aacccacatc atgtatgcct gaactggtgt 60tggctcccgt at 7262172DNAArtificial Sequencechemically synthesized 621atacgggagc caacaccagg cagcccggtc ccggactaac aaccgcggta cccaagagca 60ggtgtgacgg at 7262272DNAArtificial Sequencechemically synthesized 622atccgtcaca cctgctcttg ggtaccgcgg ttgttagtcc gggaccgggc tgcctggtgt 60tggctcccgt at 7262372DNAArtificial Sequencechemically synthesized 623atacgggagc caacaccatt cagggctttt gtgtatgcac tccagctatc agacagagca 60ggtgtgacgg at 7262472DNAArtificial Sequencechemically synthesized 624atccgtcaca cctgctctgt ctgatagctg gagtgcatac acaaaagccc tgaatggtgt 60tggctcccgt at 7262572DNAArtificial Sequencechemically synthesized 625atacgggagc caacaccaag ggacggcagg ttcgcagctg cgtcatcttt cttcagagca 60ggtgtgacgg at 7262672DNAArtificial Sequencechemically synthesized 626atccgtcaca cctgctctga agaaagatga cgcagctgcg aacctgccgt cccttggtgt 60tggctcccgt at 7262771DNAArtificial Sequencechemically synthesized 627atacgggagc caacaccacg aggacttaga cttgtccgac atcacagtgt gcgagagcag 60gtgtgacgga t 7162871DNAArtificial Sequencechemically synthesized 628atccgtcaca cctgctctcg cacactgtga tgtcggacaa gtctaagtcc tcgtggtgtt 60ggctcccgta t 7162972DNAArtificial Sequencechemically synthesized 629atacgggagc caacaccact tccctgtcct tccctcagtg aggcctgtct cctcagagca 60ggtgtgacgg at 7263072DNAArtificial Sequencechemically synthesized 630atccgtcaca cctgctctga ggagacaggc ctcactgagg gaaggacagg gaagtggtgt 60tggctcccgt at 7263172DNAArtificial Sequencechemically synthesized 631atacgggagc caacaccagg agatgttcgt gtaatagggg gttacacccg gtcgagagca 60ggtgtgacgg at 7263272DNAArtificial Sequencechemically synthesized 632atccgtcaca cctgctctcg accgggtgta accccctatt acacgaacat ctcctggtgt 60tggctcccgt at 7263372DNAArtificial Sequencechemically synthesized 633atacgggagc caacaccatc gctcaagttc ttcattactc ctatcgcttc cgctagagca 60ggtgtgacgg at 7263472DNAArtificial Sequencechemically synthesized 634atccgtcaca cctgctctag cggaagcgat aggagtaatg aagaacttga gcgatggtgt 60tggctcccgt at 7263572DNAArtificial Sequencechemically synthesized 635atacgggagc caacaccatt ctactcccag gtatgtctct gggccccccc ggccagagca 60ggtgtgacgg at 7263672DNAArtificial Sequencechemically synthesized 636atccgtcaca cctgctctgg ccgggggggc ccagagacat acctgggagt agaatggtgt 60tggctcccgt at 7263772DNAArtificial Sequencechemically synthesized 637atacgggagc caacaccaac aacatagccc tggcacgaca gtggcatacc aggcagagca 60ggtgtgacgg at 7263872DNAArtificial Sequencechemically synthesized 638atccgtcaca cctgctctgc ctggtatgcc actgtcgtgc cagggctatg ttgttggtgt 60tggctcccgt at 7263972DNAArtificial Sequencechemically synthesized 639atacgggagc caacaccacg taatgatgtg cacctctctc cgactgtttc tcgtagagca 60ggtgtgacgg at 7264072DNAArtificial Sequencechemically synthesized 640atccgtcaca cctgctctac gagaaacagt cggagagagg tgcacatcat tacgtggtgt 60tggctcccgt at 7264172DNAArtificial Sequencechemically synthesized 641atacgggagc caacaccaca tcttattcgt ccccagtcct ttggtctcct gctcagagca 60ggtgtgacgg at 7264272DNAArtificial Sequencechemically synthesized 642atccgtcaca cctgctctga gcaggagacc aaaggactgg ggacgaataa gatgtggtgt 60tggctcccgt at 7264372DNAArtificial Sequencechemically synthesized 643atacgggagc caacaccacc tgctgatttc ctataatccg gcccatacct taggagagca 60ggtgtgacgg at 7264472DNAArtificial Sequencechemically synthesized 644atccgtcaca cctgctctcc taaggtatgg gccggattat aggaaatcag caggtggtgt 60tggctcccgt at 7264572DNAArtificial Sequencechemically synthesized 645atacgggagc caacaccata agagtcctct aaggtcgctt atttttaacc cctaagagca 60ggtgtgacgg at 7264672DNAArtificial Sequencechemically synthesized 646atccgtcaca cctgctctta ggggttaaaa ataagcgacc ttagaggact cttatggtgt 60tggctcccgt at 7264772DNAArtificial Sequencechemically synthesized 647atacgggagc caacaccatc cccacaccct cgttccgacc gctagaatcc ccgaagagca 60ggtgtgacgg at 7264872DNAArtificial Sequencechemically synthesized 648atccgtcaca cctgctcttc ggggattcta gcggtcggaa cgagggtgtg gggatggtgt 60tggctcccgt at 7264972DNAArtificial Sequencechemically synthesized 649atacgggagc caacaccaca ggataatgcg tgaaattagg actaaaatgt ttgcagagca 60ggtgtgacgg at 7265072DNAArtificial Sequencechemically synthesized 650atccgtcaca cctgctctgc aaacatttta gtcctaattt cacgcattat cctgtggtgt 60tggctcccgt at 7265172DNAArtificial Sequencechemically synthesized 651atacgggagc caacaccatc tctcttagga tacaaagcca aactgagccc gtgcagagca 60ggtgtgacgg at 7265272DNAArtificial Sequencechemically synthesized 652atccgtcaca cctgctctgc acgggctcag tttggctttg tatcctaaga gagatggtgt 60tggctcccgt at 7265372DNAArtificial Sequencechemically synthesized 653atacgggagc caacaccact atctagctaa cagacttgag ataaagctac tggcagagca 60ggtgtgacgg at 7265472DNAArtificial Sequencechemically synthesized 654atccgtcaca cctgctctgc cagtagcttt atctcaagtc tgttagctag atagtggtgt 60tggctcccgt at 7265572DNAArtificial Sequencechemically synthesized 655atacgggagc caacaccaca attctacgca cataaacgca tagttctcat taccagagca 60ggtgtgacgg at 7265672DNAArtificial Sequencechemically synthesized 656atccgtcaca cctgctctgg taatgagaac tatgcgttta tgtgcgtaga attgtggtgt 60tggctcccgt at 7265772DNAArtificial Sequencechemically synthesized 657atacgggagc caacaccata aggccatgga aagtaacatc aaacaggtgg gggtagagca 60ggtgtgacgg at 7265872DNAArtificial Sequencechemically synthesized 658atccgtcaca cctgctctac ccccacctgt ttgatgttac tttccatggc cttatggtgt 60tggctcccgt at 7265972DNAArtificial Sequencechemically synthesized 659atacgggagc caacaccact acatcggcca actatgtcca cctataccat atccagagca 60ggtgtgacgg at 7266072DNAArtificial Sequencechemically synthesized 660atccgtcaca cctgctctgg atatggtata ggtggacata gttggccgat gtagtggtgt 60tggctcccgt at 7266172DNAArtificial Sequencechemically synthesized 661atacgggagc caacaccaca gaacagcccc agcgcgtgag acgattttac ctccagagca 60ggtgtgacgg at 7266272DNAArtificial Sequencechemically synthesized 662atccgtcaca cctgctctgg aggtaaaatc gtctcacgcg ctggggctgt tctgtggtgt 60tggctcccgt at 7266372DNAArtificial Sequencechemically synthesized 663atacgggagc caacaccata tcatacgatc cttgggcggg gtgagccgct gtgcagagca 60ggtgtgacgg at 7266472DNAArtificial Sequencechemically synthesized 664atccgtcaca cctgctctgc acagcggctc accccgccca aggatcgtat gatatggtgt 60tggctcccgt at 7266572DNAArtificial Sequencechemically synthesized 665atacgggagc caacaccatg agcactgcac ttccggtccc ccccctgtcc acccagagca 60ggtgtgacgg at 7266672DNAArtificial Sequencechemically synthesized 666atccgtcaca cctgctctgg gtggacaggg gggggaccgg aagtgcagtg ctcatggtgt 60tggctcccgt at 7266772DNAArtificial Sequencechemically synthesized 667atacgggagc caacaccaag tatggcggag tgcgcggacg attaaactca gtgtagagca 60ggtgtgacgg at 7266872DNAArtificial Sequencechemically synthesized 668atccgtcaca cctgctctac actgagttta atcgtccgcg cactccgcca tacttggtgt 60tggctcccgt at 7266972DNAArtificial Sequencechemically synthesized 669atacgggagc caacaccagg agagcacata tagttgacac gaaaacatac aggtagagca 60ggtgtgacgg at 7267072DNAArtificial Sequencechemically synthesized 670atccgtcaca cctgctctac ctgtatgttt tcgtgtcaac tatatgtgct ctcctggtgt 60tggctcccgt at 7267172DNAArtificial Sequencechemically synthesized 671atacgggagc caacaccata acacacgggg ccagcccatc ctctacagca taccagagca 60ggtgtgacgg at 7267272DNAArtificial Sequencechemically synthesized 672atccgtcaca cctgctctgg tatgctgtag aggatgggct ggccccgtgt gttatggtgt 60tggctcccgt at 7267372DNAArtificial Sequencechemically synthesized 673atacgggagc caacaccata gggaagcttc aacaaggttg caaacgtagg gtccagagca 60ggtgtgacgg at 7267472DNAArtificial Sequencechemically synthesized 674atccgtcaca cctgctctgg accctacgtt tgcaaccttg ttgaagcttc cctatggtgt 60tggctcccgt at 7267572DNAArtificial Sequencechemically synthesized 675atacgggagc caacaccact accaacataa tccggtccca accccgcgca ccccagagca 60ggtgtgacgg at 7267672DNAArtificial Sequencechemically synthesized 676atccgtcaca cctgctctgg ggtgcgcggg gttgggaccg gattatgttg gtagtggtgt 60tggctcccgt at 7267772DNAArtificial Sequencechemically synthesized 677atacgggagc caacaccact aagcgttaaa tgattaagca gcccgttttg ctgtagagca 60ggtgtgacgg at 7267872DNAArtificial Sequencechemically synthesized 678atccgtcaca cctgctctac agcaaaacgg gctgcttaat catttaacgc ttagtggtgt 60tggctcccgt at 7267972DNAArtificial Sequencechemically synthesized 679atacgggagc caacaccaca tagcccgaaa tattagcacc tctagggggg ggccagagca 60ggtgtgacgg at 7268072DNAArtificial Sequencechemically synthesized 680atccgtcaca cctgctctgg ccccccccta gaggtgctaa tatttcgggc tatgtggtgt 60tggctcccgt at 7268172DNAArtificial Sequencechemically synthesized 681atacgggagc caacaccacg aaaaaacgat taatatcaca agccatatgc aggtagagca 60ggtgtgacgg at 7268272DNAArtificial Sequencechemically synthesized 682atccgtcaca cctgctctac ctgcatatgg cttgtgatat taatcgtttt ttcgtggtgt 60tggctcccgt at 7268372DNAArtificial Sequencechemically synthesized 683atacgggagc caacaccagg ggacgtggag actatacaaa tgcaacttgt gggcagagca 60ggtgtgacgg at 7268472DNAArtificial Sequencechemically synthesized 684atccgtcaca

cctgctctgc ccacaagttg catttgtata gtctccacgt cccctggtgt 60tggctcccgt at 7268572DNAArtificial Sequencechemically synthesized 685atacgggagc caacaccaca cactcctttt aataactgct tagataccgg tgccagagca 60ggtgtgacgg at 7268672DNAArtificial Sequencechemically synthesized 686atccgtcaca cctgctctgg caccggtatc taagcagtta ttaaaaggag tgtgtggtgt 60tggctcccgt at 7268772DNAArtificial Sequencechemically synthesized 687atacgggagc caacaccaag agacatccag atcgaattag gtttatgaca gtgcagagca 60ggtgtgacgg at 7268872DNAArtificial Sequencechemically synthesized 688atccgtcaca cctgctctgc actgtcataa acctaattcg atctggatgt ctcttggtgt 60tggctcccgt at 7268972DNAArtificial Sequencechemically synthesized 689atacgggagc caacaccagg taaaacaatt agtacaacct gtaatcgacg tggcagagca 60ggtgtgacgg at 7269072DNAArtificial Sequencechemically synthesized 690atccgtcaca cctgctctgc cacgtcgatt acaggttgta ctaattgttt tacctggtgt 60tggctcccgt at 7269172DNAArtificial Sequencechemically synthesized 691atacgggagc caacaccacg gtccttaccc cacactcccg gttatgttgc ccccagagca 60ggtgtgacgg at 7269272DNAArtificial Sequencechemically synthesized 692atccgtcaca cctgctctgg gggcaacata accgggagtg tggggtaagg accgtggtgt 60tggctcccgt at 7269372DNAArtificial Sequencechemically synthesized 693atacgggagc caacaccatg ccggacttcg cgaaaacaca atctttgcac acccagagca 60ggtgtgacgg at 7269472DNAArtificial Sequencechemically synthesized 694atccgtcaca cctgctctgg gtgtgcaaag attgtgtttt cgcgaagtcc ggcatggtgt 60tggctcccgt at 7269572DNAArtificial Sequencechemically synthesized 695atacgggagc caacaccact ccacgcgact tgcccgaacc atgtaccctc gtccagagca 60ggtgtgacgg at 7269672DNAArtificial Sequencechemically synthesized 696atccgtcaca cctgctctgg acgagggtac atggttcggg caagtcgcgt ggagtggtgt 60tggctcccgt at 7269772DNAArtificial Sequencechemically synthesized 697atacgggagc caacaccact taaatataca gcgtagcagt gaacaaacat tgccagagca 60ggtgtgacgg at 7269872DNAArtificial Sequencechemically synthesized 698atccgtcaca cctgctctgg caatgtttgt tcactgctac gctgtatatt taagtggtgt 60tggctcccgt at 7269972DNAArtificial Sequencechemically synthesized 699atacgggagc caacaccacc tctacacccc gaactttgcg tttgctacga tcccagagca 60ggtgtgacgg at 7270072DNAArtificial Sequencechemically synthesized 700atccgtcaca cctgctctgg gatcgtagca aacgcaaagt tcggggtgta gaggtggtgt 60tggctcccgt at 7270172DNAArtificial Sequencechemically synthesized 701atacgggagc caacaccata cgcgcacgcg gattgaaagg taacgactac atagagagca 60ggtgtgacgg at 7270272DNAArtificial Sequencechemically synthesized 702atccgtcaca cctgctctct atgtagtcgt tacctttcaa tccgcgtgcg cgtatggtgt 60tggctcccgt at 7270372DNAArtificial Sequencechemically synthesized 703atacgggagc caacaccaga caacctatga agccgcttct gtcattgatt atgcagagca 60ggtgtgacgg at 7270472DNAArtificial Sequencechemically synthesized 704atccgtcaca cctgctctgc ataatcaatg acagaagcgg cttcataggt tgtctggtgt 60tggctcccgt at 7270572DNAArtificial Sequencechemically synthesized 705atacgggagc caacaccata atcaataagg gatgcaaagg gatgatagcc acgcagagca 60ggtgtgacgg at 7270672DNAArtificial Sequencechemically synthesized 706atccgtcaca cctgctctgc gtggctatca tccctttgca tcccttattg attatggtgt 60tggctcccgt at 7270772DNAArtificial Sequencechemically synthesized 707atacgggagc caacaccagg accaaccaat agagtcaaga tgacagcgac gccgagagca 60ggtgtgacgg at 7270872DNAArtificial Sequencechemically synthesized 708atccgtcaca cctgctctcg gcgtcgctgt catcttgact ctattggttg gtcctggtgt 60tggctcccgt at 7270972DNAArtificial Sequencechemically synthesized 709atacgggagc caacaccata gataattata tcactggaag agcaatcgtg gtccagagca 60ggtgtgacgg at 7271072DNAArtificial Sequencechemically synthesized 710atccgtcaca cctgctctgg accacgattg ctcttccagt gatataatta tctatggtgt 60tggctcccgt at 7271172DNAArtificial Sequencechemically synthesized 711atacgggagc caacaccacg acactagtac gactacccac gcacgtgcgc ccccagagca 60ggtgtgacgg at 7271272DNAArtificial Sequencechemically synthesized 712atccgtcaca cctgctctgg gggcgcacgt gcgtgggtag tcgtactagt gtcgtggtgt 60tggctcccgt at 7271372DNAArtificial Sequencechemically synthesized 713atacgggagc caacaccagg ccaaaaccta attttagtgg cgaagatcta tgggagagca 60ggtgtgacgg at 7271472DNAArtificial Sequencechemically synthesized 714atccgtcaca cctgctctcc catagatctt cgccactaaa attaggtttt ggcctggtgt 60tggctcccgt at 7271572DNAArtificial Sequencechemically synthesized 715atacgggagc caacaccagc gccaaacgcc ctcaccccgc accaacttcc gcccagagca 60ggtgtgacgg at 7271672DNAArtificial Sequencechemically synthesized 716atccgtcaca cctgctctgg gcggaagttg gtgcggggtg agggcgtttg gcgctggtgt 60tggctcccgt at 7271772DNAArtificial Sequencechemically synthesized 717atacgggagc caacaccata cacagccata agctgccatt cgatatagtg ccccagagca 60ggtgtgacgg at 7271872DNAArtificial Sequencechemically synthesized 718atccgtcaca cctgctctgg ggcactatat cgaatggcag cttatggctg tgtatggtgt 60tggctcccgt at 7271972DNAArtificial Sequencechemically synthesized 719atacgggagc caacaccaca acagcaaaat gattgtatgg acttgctaat caccagagca 60ggtgtgacgg at 7272072DNAArtificial Sequencechemically synthesized 720atccgtcaca cctgctctgg tgattagcaa gtccatacaa tcattttgct gttgtggtgt 60tggctcccgt at 7272172DNAArtificial Sequencechemically synthesized 721atacgggagc caacaccacc actttttgaa aataaattca atctgctaga tgggagagca 60ggtgtgacgg at 7272272DNAArtificial Sequencechemically synthesized 722atccgtcaca cctgctctcc catctagcag attgaattta ttttcaaaaa gtggtggtgt 60tggctcccgt at 7272372DNAArtificial Sequencechemically synthesized 723atacgggagc caacaccata cgcctaatat tttaaatgcg cacgtacagg ttcgagagca 60ggtgtgacgg at 7272472DNAArtificial Sequencechemically synthesized 724atccgtcaca cctgctctcg aacctgtacg tgcgcattta aaatattagg cgtatggtgt 60tggctcccgt at 7272570DNAArtificial Sequencechemically synthesized 725atacgggagc caaccccagc cagaaactct gtgaactgcc cccccccccg ccagagcagg 60tgtgacggat 7072670DNAArtificial Sequencechemically synthesized 726atccgtcaca cctgctctgg cggggggggg ggcagttcac agagtttctg gctggggttg 60gctcccgtat 7072772DNAArtificial Sequencechemically synthesized 727atacgggagc caacaccaca tcctagccac taacagaaac tatatcccct ttgcagagca 60ggtgtgacgg at 7272872DNAArtificial Sequencechemically synthesized 728atccgtcaca cctgctctgc aaaggggata tagtttctgt tagtggctag gatgtggtgt 60tggctcccgt at 7272972DNAArtificial Sequencechemically synthesized 729atacgggagc caacaccatc acatactatg cctgaaccca ttaagtttgt cgcgagagca 60ggtgtgacgg at 7273072DNAArtificial Sequencechemically synthesized 730atccgtcaca cctgctctcg cgacaaactt aatgggttca ggcatagtat gtgatggtgt 60tggctcccgt at 7273172DNAArtificial Sequencechemically synthesized 731atacgggagc caacaccatg aaatttatct agttgtcatt atatgaggga tcccagagca 60ggtgtgacgg at 7273272DNAArtificial Sequencechemically synthesized 732atccgtcaca cctgctctgg gatccctcat ataatgacaa ctagataaat ttcatggtgt 60tggctcccgt at 7273372DNAArtificial Sequencechemically synthesized 733atacgggagc caacaccagg ccggccccgc ggggcgactt gtactgtaaa gcttagagca 60ggtgtgacgg at 7273472DNAArtificial Sequencechemically synthesized 734atccgtcaca cctgctctaa gctttacagt acaagtcgcc ccgcggggcc ggcctggtgt 60tggctcccgt at 7273572DNAArtificial Sequencechemically synthesized 735atacgggagc caacaccacc ccttgccata ttggctgcgg ctccacggcg gtcgagagca 60ggtgtgacgg at 7273672DNAArtificial Sequencechemically synthesized 736atccgtcaca cctgctctcg accgccgtgg agccgcagcc aatatggcaa ggggtggtgt 60tggctcccgt at 7273771DNAArtificial Sequencechemically synthesized 737atacgggagc caacaccagc ccactcacaa ccctcctctt tcatttgcct accagagcag 60gtgtgacgga t 7173871DNAArtificial Sequencechemically synthesized 738atccgtcaca cctgctctgg taggcaaatg aaagaggagg gttgtgagtg ggctggtgtt 60ggctcccgta t 7173972DNAArtificial Sequencechemically synthesized 739atacgggagc caacaccacg ctacggggcg gctaaaggcc gacgaataaa ctctagagca 60ggtgtgacgg at 7274072DNAArtificial Sequencechemically synthesized 740atccgtcaca cctgctctag agtttattcg tcggccttta gccgccccgt agcgtggtgt 60tggctcccgt at 7274172DNAArtificial Sequencechemically synthesized 741atacgggagc caacaccatc atagaccgta ataattgaat ctaagaaacc gtgtagagca 60ggtgtgacgg at 7274272DNAArtificial Sequencechemically synthesized 742atccgtcaca cctgctctac acggtttctt agattcaatt attacggtct atgatggtgt 60tggctcccgt at 7274372DNAArtificial Sequencechemically synthesized 743atacgggagc caacaccata cctataaatg gaaaatatgg gatcctagta acgcagagca 60ggtgtgacgg at 7274472DNAArtificial Sequencechemically synthesized 744atccgtcaca cctgctctgc gttactagga tcccatattt tccatttata ggtatggtgt 60tggctcccgt at 7274572DNAArtificial Sequencechemically synthesized 745atacgggagc caacaccacc cactctcccc ccgctcccgc tcccccgctc cgcgagagca 60ggtgtgacgg at 7274672DNAArtificial Sequencechemically synthesized 746atccgtcaca cctgctctcg cggagcgggg gagcgggagc ggggggagag tgggtggtgt 60tggctcccgt at 7274772DNAArtificial Sequencechemically synthesized 747atacgggagc caacaccata cctgaccccc cgccgcaatc ctagtctacc tccgagagca 60ggtgtgacgg at 7274872DNAArtificial Sequencechemically synthesized 748atccgtcaca cctgctctcg gaggtagact aggattgcgg cggggggtca ggtatggtgt 60tggctcccgt at 7274972DNAArtificial Sequencechemically synthesized 749atacgggagc caacaccacc cgtggccttc acccagccag ggaccccgtc tctgagagca 60ggtgtgacgg at 7275072DNAArtificial Sequencechemically synthesized 750atccgtcaca cctgctctca gagacggggt ccctggctgg gtgaaggcca cgggtggtgt 60tggctcccgt at 7275172DNAArtificial Sequencechemically synthesized 751atacgggagc caacaccaca cacagagcgc catggactca gtcagatgtg atgtagagca 60ggtgtgacgg at 7275272DNAArtificial Sequencechemically synthesized 752atccgtcaca cctgctctac atcacatctg actgagtcca tggcgctctg tgtgtggtgt 60tggctcccgt at 7275372DNAArtificial Sequencechemically synthesized 753atacgggagc caacaccatc cctcttagga tacaaagcca aactgagccc gtgcagagca 60ggtgtgacgg at 7275472DNAArtificial Sequencechemically synthesized 754atccgtcaca cctgctctgc acgggctcag tttggctttg tatcctaaga gggatggtgt 60tggctcccgt at 7275572DNAArtificial Sequencechemically synthesized 755atacgggagc caacaccatc agcagctctg cttacaggcg cccgtaatcc ggacagagca 60ggtgtgacgg at 7275672DNAArtificial Sequencechemically synthesized 756atccgtcaca cctgctctgt ccggattacg ggcgcctgta agcagagctg ctgatggtgt 60tggctcccgt at 7275773DNAArtificial Sequencechemically synthesized 757atacgggagc caacaccatg tgccaggtag agcccgataa tccttacagt acgctagagc 60aggtgtgacg gat 7375873DNAArtificial Sequencechemically synthesized 758atccgtcaca cctgctctag cgtactgtaa ggattatcgg gctctacctg gcacatggtg 60ttggctcccg tat 7375972DNAArtificial Sequencechemically synthesized 759atacgggagc caacaccacg tacataccct ccatctaacc gccgtcccca gtcaagagca 60ggtgtgacgg at 7276072DNAArtificial Sequencechemically synthesized 760atccgtcaca cctgctcttg actggggacg gcggttagat ggagggtatg tacgtggtgt 60tggctcccgt at 7276171DNAArtificial Sequencechemically synthesized 761atacgggagc caacaccacg aggacctaga cttgtccgac atcacagtgt gcgagagcag 60gtgtgacgga t 7176271DNAArtificial Sequencechemically synthesized 762atccgtcaca cctgctctcg cacactgtga tgtcggacaa gtctaggtcc tcgtggtgtt 60ggctcccgta t 7176372DNAArtificial Sequencechemically synthesized 763atacgggagc caacaccacg tattgcgcga tccgttgcca actcttatcg ggccagagca 60ggtgtgacgg at 7276472DNAArtificial Sequencechemically synthesized 764atccgtcaca cctgctctgg cccgataaga gttggcaacg gatcgcgcaa tacgtggtgt 60tggctcccgt at 7276572DNAArtificial Sequencechemically synthesized 765atacgggagc caacaccacc cgcaccctga tcccttccac ccgtcccctc ccgcagagca 60ggtgtgacgg at 7276672DNAArtificial Sequencechemically synthesized 766atccgtcaca cctgctctgc gggaggggac gggtggaagg gatcagggtg cgggtggtgt 60tggctcccgt at 7276772DNAArtificial Sequencechemically synthesized 767atacgggagc caacaccatg aaatggtccg atgctgtatt atccctccgc agcgagagca 60ggtgtgacgg at

7276872DNAArtificial Sequencechemically synthesized 768atccgtcaca cctgctctcg ctgcggaggg ataatacagc atcggaccat ttcatggtgt 60tggctcccgt at 7276972DNAArtificial Sequencechemically synthesized 769atacgggagc caacaccata cgggatagcg ggtaggatcc cgtgccatca cgtcagagca 60ggtgtgacgg at 7277072DNAArtificial Sequencechemically synthesized 770atccgtcaca cctgctctga cgtgatggca cgggatccta cccgctatcc cgtatggtgt 60tggctcccgt at 7277172DNAArtificial Sequencechemically synthesized 771atacgggagc caacaccagg ttgacatctg taaagttccg tactggtggc taggagagca 60ggtgtgacgg at 7277272DNAArtificial Sequencechemically synthesized 772atccgtcaca cctgctctcc tagccaccag tacggaactt tacagatgtc aacctggtgt 60tggctcccgt at 7277372DNAArtificial Sequencechemically synthesized 773atacgggagc caacaccacc cccataccgt acactgtcca tcccgccttt ctccagagca 60ggtgtgacgg at 7277472DNAArtificial Sequencechemically synthesized 774atccgtcaca cctgctctgg agaaaggcgg gatggacagt gtacggtatg ggggtggtgt 60tggctcccgt at 7277572DNAArtificial Sequencechemically synthesized 775atacgggagc caacaccacg gagtgcccag tgcaagttta cgccagatgt gcgcagagca 60ggtgtgacgg at 7277672DNAArtificial Sequencechemically synthesized 776atccgtcaca cctgctctgc gcacatctgg cgtaaacttg cactgggcac tccgtggtgt 60tggctcccgt at 7277772DNAArtificial Sequencechemically synthesized 777atacgggagc caacaccacc tgtcatccat gctccgcttc tcccggtacc gtccagagca 60ggtgtgacgg at 7277872DNAArtificial Sequencechemically synthesized 778atccgtcaca cctgctctgg acggtaccgg gagaagcgga gcatggatga caggtggtgt 60tggctcccgt at 7277972DNAArtificial Sequencechemically synthesized 779atacgggagc caacaccacc cgtggccttc acccagccag gggccccgtc tctgagagca 60ggtgtgacgg at 7278072DNAArtificial Sequencechemically synthesized 780atccgtcaca cctgctctca gagacggggc ccctggctgg gtgaaggcca cgggtggtgt 60tggctcccgt at 7278172DNAArtificial Sequencechemically synthesized 781atacgggagc caacaccagg agcgtccccc gtcccccgca cccaacggcg agccagagca 60ggtgtgacgg at 7278272DNAArtificial Sequencechemically synthesized 782atccgtcaca cctgctctgg ctcgccgttg ggtgcggggg acgggggacg ctcctggtgt 60tggctcccgt at 7278372DNAArtificial Sequencechemically synthesized 783atacgggagc caacaccaat agagcgtcta cccgtatccc gccttggatt ccacagagca 60ggtgtgacgg at 7278472DNAArtificial Sequencechemically synthesized 784atccgtcaca cctgctctgt ggaatccaag gcgggatacg ggtagacgct ctattggtgt 60tggctcccgt at 7278572DNAArtificial Sequencechemically synthesized 785atacgggagc caacaccact gtctacgtgg gtctcacagt ccgtgctatt tgccagagca 60ggtgtgacgg at 7278672DNAArtificial Sequencechemically synthesized 786atccgtcaca cctgctctgg caaatagcac ggactgtgag acccacgtag acagtggtgt 60tggctcccgt at 7278772DNAArtificial Sequencechemically synthesized 787atacgggagc caacaccata caccacagca cacaagattc aggctagaga cgggagagca 60ggtgtgacgg at 7278872DNAArtificial Sequencechemically synthesized 788atccgtcaca cctgctctcc cgtctctagc ctgaatcttg tgtgctgtgg tgtatggtgt 60tggctcccgt at 7278972DNAArtificial Sequencechemically synthesized 789atacgggagc caacaccaca tgcgcacctt tccctcctcc aactcgaatc cgccagagca 60ggtgtgacgg at 7279072DNAArtificial Sequencechemically synthesized 790atccgtcaca cctgctctgg cggattcgag ttggaggagg gaaaggtgcg catgtggtgt 60tggctcccgt at 7279172DNAArtificial Sequencechemically synthesized 791atacgggagc caacaccatg gggggtacgg agagtgatac ttggaggttg ggccagagca 60ggtgtgacgg at 7279272DNAArtificial Sequencechemically synthesized 792atccgtcaca cctgctctgg cccaacctcc aagtatcact ctccgtaccc cccatggtgt 60tggctcccgt at 7279372DNAArtificial Sequencechemically synthesized 793atacgggagc caacaccact ggaattcaaa aatactacac tatattgctg tggcagagca 60ggtgtgacgg at 7279472DNAArtificial Sequencechemically synthesized 794atccgtcaca cctgctctgc cacagcaata tagtgtagta tttttgaatt ccagtggtgt 60tggctcccgt at 7279572DNAArtificial Sequencechemically synthesized 795atacgggagc caacaccagg ccagggtaac ttaaaacagc attatctatt gtacagagca 60ggtgtgacgg at 7279672DNAArtificial Sequencechemically synthesized 796atccgtcaca cctgctctgt acaatagata atgctgtttt aagttaccct ggcctggtgt 60tggctcccgt at 7279772DNAArtificial Sequencechemically synthesized 797atacgggagc caacaccacc acattccggc cgaacgactt ataagtaaca attcagagca 60ggtgtgacgg at 7279872DNAArtificial Sequencechemically synthesized 798atccgtcaca cctgctctga attgttactt ataagtcgtt cggccggaat gtggtggtgt 60tggctcccgt at 7279972DNAArtificial Sequencechemically synthesized 799atacgggagc caacaccaca caaagaagta gaatgtatgg gaatgaattg acatagagca 60ggtgtgacgg at 7280071DNAArtificial Sequencechemically synthesized 800atccgtcaca cctgctctat gtcaattcat tcccatacat tctacttctt tgtgtggtgt 60tggctcccgt a 7180172DNAArtificial Sequencechemically synthesized 801atacgggagc caacaccact gggacacttc aacctgtaac atactcattc ggtgagagca 60ggtgtgacgg at 7280272DNAArtificial Sequencechemically synthesized 802atccgtcaca cctgctctca ccgaatgagt atgttacagg ttgaagtgtc ccagtggtgt 60tggctcccgt at 7280372DNAArtificial Sequencechemically synthesized 803atacgggagc caacaccacc cctctctcgt acgccgcccg gggtccacct acccagagca 60ggtgtgacgg at 7280472DNAArtificial Sequencechemically synthesized 804atccgtcaca cctgctctgg gtaggtggac cccgggcggc gtacgagaga ggggtggtgt 60tggctcccgt at 7280572DNAArtificial Sequencechemically synthesized 805atacgggagc caacaccatg ggggatgtga tgatgagcag gctatggtct ctccagagca 60ggtgtgacgg at 7280672DNAArtificial Sequencechemically synthesized 806atccgtcaca cctgctctgg agagaccata gcctgctcat catcacatcc cccatggtgt 60tggctcccgt at 7280772DNAArtificial Sequencechemically synthesized 807atacgggagc caacaccacg gcatgcaact atttaataac attgttgctt gggtagagca 60ggtgtgacgg at 7280872DNAArtificial Sequencechemically synthesized 808atccgtcaca cctgctctac ccaagcaaca atgttattaa atagttgcat gccgtggtgt 60tggctcccgt at 7280972DNAArtificial Sequencechemically synthesized 809atacgggagc caacaccatt agaaacatca gtagacaaac taaggtttta cgggagagca 60ggtgtgacgg at 7281072DNAArtificial Sequencechemically synthesized 810atccgtcaca cctgctctcc cgtaaaacct tagtttgtct actgatgttt ctaatggtgt 60tggctcccgt at 7281172DNAArtificial Sequencechemically synthesized 811atacgggagc caacaccata cctatattgt taactagaag tggggtcagg ggagagagca 60ggtgtgacgg at 7281272DNAArtificial Sequencechemically synthesized 812atccgtcaca cctgctctct cccctgaccc cacttctagt taacaatata ggtatggtgt 60tggctcccgt at 7281372DNAArtificial Sequencechemically synthesized 813atacgggagc caacaccatg gtcgaccctc cttgaggact aatctctaca ctcgagagca 60ggtgtgacgg at 7281472DNAArtificial Sequencechemically synthesized 814atccgtcaca cctgctctcg agtgtagaga ttagtcctca aggagggtcg accatggtgt 60tggctcccgt at 7281572DNAArtificial Sequencechemically synthesized 815atacgggagc caacaccata cgaagaccgt taggatgcca cccaagttaa ttacagagca 60ggtgtgacgg at 7281672DNAArtificial Sequencechemically synthesized 816atccgtcaca cctgctctgt aattaacttg ggtggcatcc taacggtctt cgtatggtgt 60tggctcccgt at 7281772DNAArtificial Sequencechemically synthesized 817atacgggagc caacaccatg ctaatataaa catctatcca tattaaccat gtccagagca 60ggtgtgacgg at 7281872DNAArtificial Sequencechemically synthesized 818atccgtcaca cctgctctgg acatggttaa tatggataga tgtttatatt agcatggtgt 60tggctcccgt at 7281972DNAArtificial Sequencechemically synthesized 819atacgggagc caacaccaga gtgaataaag acccttcggc gaccagccgc ccccagagca 60ggtgtgacgg at 7282072DNAArtificial Sequencechemically synthesized 820atccgtcaca cctgctctgg gggcggctgg tcgccgaagg gtctttattc actctggtgt 60tggctcccgt at 7282172DNAArtificial Sequencechemically synthesized 821atacgggagc caacaccatg agaccgcgcc cgtgacatag aatccccttc ccgtagagca 60ggtgtgacgg at 7282272DNAArtificial Sequencechemically synthesized 822atccgtcaca cctgctctac gggaagggga ttctatgtca cgggcgcggt ctcatggtgt 60tggctcccgt at 7282372DNAArtificial Sequencechemically synthesized 823atacgggagc caacaccaac aggatgttaa gaggtgagag ggcaggcgag gtccagagca 60ggtgtgacgg at 7282472DNAArtificial Sequencechemically synthesized 824atccgtcaca cctgctctgg acctcgcctg ccctctcacc tcttaacatc ctgttggtgt 60tggctcccgt at 7282572DNAArtificial Sequencechemically synthesized 825atacgggagc caacaccagc catcgttcag tacattacga acccatctta ccccagagca 60ggtgtgacgg at 7282672DNAArtificial Sequencechemically synthesized 826atccgtcaca cctgctctgg ggtaagatgg gttcgtaatg tactgaacga tggctggtgt 60tggctcccgt at 7282776DNAArtificial Sequencechemically synthesized 827atacgggagc caacaccaca gcaggtgtga cggatgaggt cgaattccag cacactggcg 60gccgttacta atggat 7682876DNAArtificial Sequencechemically synthesized 828atccattagt aacggccgcc agtgtgctgg aattcgacct catccgtcac acctgctgtg 60gtgttggctc ccgtat 7682972DNAArtificial Sequencechemically synthesized 829atacgggagc caacaccatg ataagccaag atgttcaata tttataagtc tcccagagca 60ggtgtgacgg at 7283072DNAArtificial Sequencechemically synthesized 830atccgtcaca cctgctctgg gagacttata aatattgaac atcttggctt atcatggtgt 60tggctcccgt at 7283172DNAArtificial Sequencechemically synthesized 831atacgggagc caacaccagc actacccgct tattgaaatg tggtgtatta ttggagagca 60ggtgtgacgg at 7283272DNAArtificial Sequencechemically synthesized 832atccgtcaca cctgctctcc aataatacac cacatttcaa taagcgggta gtgctggtgt 60tggctcccgt at 7283372DNAArtificial Sequencechemically synthesized 833atacgggagc caacaccaag acgcgcaaaa aaaacacgga aagattactc ggacagagca 60ggtgtgacgg at 7283472DNAArtificial Sequencechemically synthesized 834atccgtcaca cctgctctgt ccgagtaatc tttccgtgtt ttttttgcgc gtcttggtgt 60tggctcccgt at 7283572DNAArtificial Sequencechemically synthesized 835atacgggagc caacaccaca ttgtactcca ccctaccgaa aagcccattt cagcagagca 60ggtgtgacgg at 7283672DNAArtificial Sequencechemically synthesized 836atccgtcaca cctgctctgc tgaaatgggc ttttcggtag ggtggagtac aatgtggtgt 60tggctcccgt at 7283772DNAArtificial Sequencechemically synthesized 837atacgggagc caacaccaga aacaaggtgg cccaaataca agcactagct ttagagagca 60ggtgtgacgg at 7283872DNAArtificial Sequencechemically synthesized 838atccgtcaca cctgctctct aaagctagtg cttgtatttg ggccaccttg tttctggtgt 60tggctcccgt at 7283972DNAArtificial Sequencechemically synthesized 839atacgggagc caacaccaaa ggctgtaggg gggaggaaat attgggatcc tggcagagca 60ggtgtgacgg at 7284072DNAArtificial Sequencechemically synthesized 840atccgtcaca cctgctctgc caggatccca atatttcctc ccccctacag cctttggtgt 60tggctcccgt at 7284172DNAArtificial Sequencechemically synthesized 841atacgggagc caacaccaca ggatatcaac gcactaaaaa tctaggatct ttggagagca 60ggtgtgacgg at 7284272DNAArtificial Sequencechemically synthesized 842atccgtcaca cctgctctcc aaagatccta gatttttagt gcgttgatat cctgtggtgt 60tggctcccgt at 7284372DNAArtificial Sequencechemically synthesized 843atacgggagc caacaccagt gagtcgatag accgacatgt gtctggtaat ctgtagagca 60ggtgtgacgg at 7284472DNAArtificial Sequencechemically synthesized 844atccgtcaca cctgctctac agattaccag acacatgtcg gtctatcgac tcactggtgt 60tggctcccgt at 7284572DNAArtificial Sequencechemically synthesized 845atacgggagc caacaccaat aggttccagg gcgtagctat tagcgctaac cagaagagca 60ggtgtgacgg at 7284672DNAArtificial Sequencechemically synthesized 846atccgtcaca cctgctcttc tggttagcgc taatagctac gccctggaac ctattggtgt 60tggctcccgt at 7284772DNAArtificial Sequencechemically synthesized 847atacgggagc caacaccagc gcctctaccg ccgcccaccg catccacgca catcagagca 60ggtgtgacgg at 7284872DNAArtificial Sequencechemically synthesized 848atccgtcaca cctgctctga tgtgcgtgga tgcggtgggc ggcggtagag gcgctggtgt 60tggctcccgt at 7284972DNAArtificial Sequencechemically synthesized 849atacgggagc caacaccact ttatagaaac atgcaccgat ctattgttgt gaggagagca 60ggtgtgacgg at 7285072DNAArtificial Sequencechemically synthesized 850atccgtcaca cctgctctcc tcacaacaat agatcggtgc atgtttctat aaagtggtgt 60tggctcccgt at 7285172DNAArtificial Sequencechemically synthesized 851atacgggagc caacaccaaa aactgacgag gtgagtatta tatttaaggc atatagagca 60ggtgtgacgg

at 7285272DNAArtificial Sequencechemically synthesized 852atccgtcaca cctgctctat atgccttaaa tataatactc acctcgtcag tttttggtgt 60tggctcccgt at 7285372DNAArtificial Sequencechemically synthesized 853atacgggagc caacaccagc agtgtgatct ggttacactg tggatacgat acggagagca 60ggtgtgacgg at 7285472DNAArtificial Sequencechemically synthesized 854atccgtcaca cctgctctcc gtatcgtatc cacagtgtaa ccagatcaca ctgctggtgt 60tggctcccgt at 7285572DNAArtificial Sequencechemically synthesized 855atacgggagc caacaccaca cgataatcgg tagaaactta aatactaccc gtccagagca 60ggtgtgacgg at 7285672DNAArtificial Sequencechemically synthesized 856atccgtcaca cctgctctgg acgggtagta tttaagtttc taccgattat cgtgtggtgt 60tggctcccgt at 7285772DNAArtificial Sequencechemically synthesized 857atacgggagc caacaccata tgtcagagaa agaagtctca tcctttagac ccccagagca 60ggtgtgacgg at 7285872DNAArtificial Sequencechemically synthesized 858atccgtcaca cctgctctgg gggtctaaag gatgagactt ctttctctga catatggtgt 60tggctcccgt at 7285972DNAArtificial Sequencechemically synthesized 859atacgggagc caacaccacc taaccatccg atgccttctg tcatgaaagc atctagagca 60ggtgtgacgg at 7286072DNAArtificial Sequencechemically synthesized 860atccgtcaca cctgctctag atgctttcat gacagaaggc atcggatggt taggtggtgt 60tggctcccgt at 7286172DNAArtificial Sequencechemically synthesized 861atacgggagc caacaccagc ccaagtaggc agaaagtgaa caatgcttct gaccagagca 60ggtgtgacgg at 7286272DNAArtificial Sequencechemically synthesized 862atccgtcaca cctgctctgg tcagaagcat tgttcacttt ctgcctactt gggctggtgt 60tggctcccgt at 7286372DNAArtificial Sequencechemically synthesized 863atacgggagc caacaccaag gcacgcgcac cagctggaaa gcccatggta cctcagagca 60ggtgtgacgg at 7286472DNAArtificial Sequencechemically synthesized 864atccgtcaca cctgctctga ggtaccatgg gctttccagc tggtgcgcgt gccttggtgt 60tggctcccgt at 7286572DNAArtificial Sequencechemically synthesized 865atacgggagc caacaccaca accttttctc tcaagcccct ctgcccccac tcagagagca 60ggtgtgacgg at 7286672DNAArtificial Sequencechemically synthesized 866atccgtcaca cctgctctct gagtgggggc agaggggctt gagagaaaag gttgtggtgt 60tggctcccgt at 7286772DNAArtificial Sequencechemically synthesized 867atacgggagc caacaccaca caataaaacg aacaccaaca gacaatacat tcacagagca 60ggtgtgacgg at 7286872DNAArtificial Sequencechemically synthesized 868atccgtcaca cctgctctgt gaatgtattg tctgttggtg ttcgttttat tgtgtggtgt 60tggctcccgt at 7286972DNAArtificial Sequencechemically synthesized 869atacgggagc caacaccagt gcctggccaa gccctctcac ttggcaatga tggcagagca 60ggtgtgacgg at 7287072DNAArtificial Sequencechemically synthesized 870atccgtcaca cctgctctgc catcattgcc aagtgagagg gcttggccag gcactggtgt 60tggctcccgt at 7287171DNAArtificial Sequencechemically synthesized 871atacgggagc caacaccaag caactaagaa caagttataa ctatattacg gggagagcag 60gtgtgacgga t 7187271DNAArtificial Sequencechemically synthesized 872atccgtcaca cctgctctcc ccgtaatata gttataactt gttcttagtt gcttggtgtt 60ggctcccgta t 7187372DNAArtificial Sequencechemically synthesized 873atacgggagc caacaccaat gaaacatgcc gattgcttaa cagtgtattc tgatagagca 60ggtgtgacgg at 7287472DNAArtificial Sequencechemically synthesized 874atccgtcaca cctgctctat cagaatacac tgttaagcaa tcggcatgtt tcattggtgt 60tggctcccgt at 7287572DNAArtificial Sequencechemically synthesized 875atacgggagc caacaccata caccaactac tgagattcga gttaccgaaa tcgtagagca 60ggtgtgacgg at 7287672DNAArtificial Sequencechemically synthesized 876atccgtcaca cctgctctac gatttcggta actcgaatct cagtagttgg tgtatggtgt 60tggctcccgt at 7287772DNAArtificial Sequencechemically synthesized 877atacgggagc caacaccaat gatgcgccaa gggttgccgg cggctcgatt tgcgagagca 60ggtgtgacgg at 7287872DNAArtificial Sequencechemically synthesized 878atccgtcaca cctgctctcg caaatcgagc cgccggcaac ccttggcgca tcattggtgt 60tggctcccgt at 7287971DNAArtificial Sequencechemically synthesized 879atacgggagc caacaccagc cggtgtatag aatgatggag atgtagtttt ggaagagcag 60gtgtgacgga t 7188071DNAArtificial Sequencechemically synthesized 880atccgtcaca cctgctcttc caaaactaca tctccatcat tctatacacc ggctggtgtt 60ggctcccgta t 7188172DNAArtificial Sequencechemically synthesized 881atacgggagc caacaccaag cggaggtaac acaataatgt gagagactgg tgaaagagca 60ggtgtgacgg at 7288272DNAArtificial Sequencechemically synthesized 882atccgtcaca cctgctcttt caccagtctc tcacattatt gtgttacctc cgcttggtgt 60tggctcccgt at 7288372DNAArtificial Sequencechemically synthesized 883atacgggagc caacaccatt cacatctatc cctcacagcg cctgagctgt cacgagagca 60ggtgtgacgg at 7288472DNAArtificial Sequencechemically synthesized 884atccgtcaca cctgctctcg tgacagctca ggcgctgtga gggatagatg tgaatggtgt 60tggctcccgt at 7288572DNAArtificial Sequencechemically synthesized 885atacgggagc caacaccagg tcccgcctgc ttaagttcgt ctatcttgcc ttcaagagca 60ggtgtgacgg at 7288672DNAArtificial Sequencechemically synthesized 886atccgtcaca cctgctcttg aaggcaagat agacgaactt aagcaggcgg gacctggtgt 60tggctcccgt at 7288772DNAArtificial Sequencechemically synthesized 887atacgggagc caacaccagc tcctgttaac gaatctttaa gccatgctgt gcggagagca 60ggtgtgacgg at 7288872DNAArtificial Sequencechemically synthesized 888atccgtcaca cctgctctcc gcacagcatg gcttaaagat tcgttaacag gagctggtgt 60tggctcccgt at 7288972DNAArtificial Sequencechemically synthesized 889atacgggagc caacaccagt aaccgataca tagacgaaaa gttggctacg aatgagagca 60ggtgtgacgg at 7289072DNAArtificial Sequencechemically synthesized 890atccgtcaca cctgctctca ttcgtagcca acttttcgtc tatgtatcgg ttactggtgt 60tggctcccgt at 7289172DNAArtificial Sequencechemically synthesized 891atacgggagc caacaccagc ttgcggcggg atcggagtaa acttaatgtc gtggagagca 60ggtgtgacgg at 7289272DNAArtificial Sequencechemically synthesized 892atccgtcaca cctgctctcc acgacattaa gtttactccg atcccgccgc aagctggtgt 60tggctcccgt at 7289372DNAArtificial Sequencechemically synthesized 893atacgggagc caacaccaga caattttgat gtgagcgaaa aacaggtccc gcccagagca 60ggtgtgacgg at 7289472DNAArtificial Sequencechemically synthesized 894atccgtcaca cctgctctgg gcgggacctg tttttcgctc acatcaaaat tgtctggtgt 60tggctcccgt at 7289572DNAArtificial Sequencechemically synthesized 895atacgggagc caacaccacg agtgggttca atgagactgc ataatgacac ccgtagagca 60ggtgtgacgg at 7289672DNAArtificial Sequencechemically synthesized 896atccgtcaca cctgctctac gggtgtcatt atgcagtctc attgaaccca ctcgtggtgt 60tggctcccgt at 7289772DNAArtificial Sequencechemically synthesized 897atacgggagc caacaccata gtcctgaaac gatcagatga aaataaatag ttgtagagca 60ggtgtgacgg at 7289872DNAArtificial Sequencechemically synthesized 898atccgtcaca cctgctctac aactatttat tttcatctga tcgtttcagg actatggtgt 60tggctcccgt at 7289972DNAArtificial Sequencechemically synthesized 899atacgggagc caacaccatg gtacacaagg tatggtctgg atgttcgagc ctaaagagca 60ggtgtgacgg at 7290072DNAArtificial Sequencechemically synthesized 900atccgtcaca cctgctcttt aggctcgaac atccagacca taccttgtgt accatggtgt 60tggctcccgt at 7290172DNAArtificial Sequencechemically synthesized 901atacgggagc caacaccagg gctgaccaat taacctgtta acataaatcc ctcaagagca 60ggtgtgacgg at 7290272DNAArtificial Sequencechemically synthesized 902atccgtcaca cctgctcttg agggatttat gttaacaggt taattggtca gccctggtgt 60tggctcccgt at 7290372DNAArtificial Sequencechemically synthesized 903atacgggagc caacaccata ggcaaaacca gaataagatg cagtgttggg aagtagagca 60ggtgtgacgg at 7290472DNAArtificial Sequencechemically synthesized 904atccgtcaca cctgctctac ttcccaacac tgcatcttat tctggttttg cctatggtgt 60tggctcccgt at 7290572DNAArtificial Sequencechemically synthesized 905atacgggagc caacaccata tttagggggt aaaatgtatg ggatgtttct ttacagagca 60ggtgtgacgg at 7290672DNAArtificial Sequencechemically synthesized 906atccgtcaca cctgctctgt aaagaaacat cccatacatt ttacccccta aatatggtgt 60tggctcccgt at 7290772DNAArtificial Sequencechemically synthesized 907atacgggagc caacaccagg gccggatccg ctctaatagc taacatgttg gatcagagca 60ggtgtgacgg at 7290872DNAArtificial Sequencechemically synthesized 908atccgtcaca cctgctctga tccaacatgt tagctattag agcggatccg gccctggtgt 60tggctcccgt at 7290972DNAArtificial Sequencechemically synthesized 909atacgggagc caacaccacc accctcgagc cgaacatctc cccgccgatt cttcagagca 60ggtgtgacgg at 7291072DNAArtificial Sequencechemically synthesized 910atccgtcaca cctgctctga agaatcggcg gggagatgtt cggctcgagg gtggtggtgt 60tggctcccgt at 7291172DNAArtificial Sequencechemically synthesized 911atacgggagc caacaccatc caatgaggcc atggaccggt aaactcggac gcgcagagca 60ggtgtgacgg at 7291272DNAArtificial Sequencechemically synthesized 912atccgtcaca cctgctctgc gcgtccgagt ttaccggtcc atggcctcat tggatggtgt 60tggctcccgt at 7291373DNAArtificial Sequencechemically synthesized 913atacgggagc caacaccact atgaccgtgc cccgtttgga tcatcgagct ggctcagagc 60aggtgtgacg gat 7391473DNAArtificial Sequencechemically synthesized 914atccgtcaca cctgctctga gccagctcga tgatccaaac ggggcacggt catagtggtg 60ttggctcccg tat 7391572DNAArtificial Sequencechemically synthesized 915atacgggagc caacaccact atcccccgat tcagcgcatt ctcagcatat ccccagagca 60ggtgtgacgg at 7291672DNAArtificial Sequencechemically synthesized 916atccgtcaca cctgctctgg ggatatgctg agaatgcgct gaatcggggg atagtggtgt 60tggctcccgt at 7291772DNAArtificial Sequencechemically synthesized 917atacgggagc caacaccata gaagagagag agaatgacag tcaggtgtag caccagagca 60ggtgtgacgg at 7291872DNAArtificial Sequencechemically synthesized 918atccgtcaca cctgctctgg tgctacacct gactgtcatt ctctctctct tctatggtgt 60tggctcccgt at 7291972DNAArtificial Sequencechemically synthesized 919atacgggagc caacaccaaa cattacaacg atgtgggtga atattccgcg ttccagagca 60ggtgtgacgg at 7292072DNAArtificial Sequencechemically synthesized 920atccgtcaca cctgctctgg aacgcggaat attcacccac atcgttgtaa tgtttggtgt 60tggctcccgt at 7292172DNAArtificial Sequencechemically synthesized 921atacgggagc caacaccagc gaatcttata aaacaacacc actaacctta tgacagagca 60ggtgtgacgg at 7292272DNAArtificial Sequencechemically synthesized 922atccgtcaca cctgctctgt cataaggtta gtggtgttgt tttataagat tcgctggtgt 60tggctcccgt at 7292372DNAArtificial Sequencechemically synthesized 923atacgggagc caacaccacc gaatgtgctg caagactaat ctggatggcc atgcagagca 60ggtgtgacgg at 7292472DNAArtificial Sequencechemically synthesized 924atccgtcaca cctgctctgc atggccatcc agattagtct tgcagcacat tcggtggtgt 60tggctcccgt at 7292572DNAArtificial Sequencechemically synthesized 925atacgggagc caacaccacc gcgcacatgg gcggagccgc tactctcccc cgctagagca 60ggtgtgacgg at 7292672DNAArtificial Sequencechemically synthesized 926atccgtcaca cctgctctag cgggggagag tagcggctcc gcccatgtgc gcggtggtgt 60tggctcccgt at 7292772DNAArtificial Sequencechemically synthesized 927atacgggagc caacaccacg ataagtgcga cttctctaca tccttaaccc ccccagagca 60ggtgtgacgg at 7292872DNAArtificial Sequencechemically synthesized 928atccgtcaca cctgctctgg gggggttaag gatgtagaga agtcgcactt atcgtggtgt 60tggctcccgt at 7292971DNAArtificial Sequencechemically synthesized 929atacgggagc caacaccaga atagttgtgc tgataaggaa atcattcggg gccaaaacaa 60gggtgacgga t 7193071DNAArtificial Sequencechemically synthesized 930atccgtcacc cttgttttgg ccccgaatga tttccttatc agcacaacta ttctggtgtt 60ggctcccgta t 7193172DNAArtificial Sequencechemically synthesized 931atacgggagc caacaccatt tcgactctgg tccgaatgct tatcgatgtg cctgagagca 60ggtgtgacgg at 7293272DNAArtificial Sequencechemically synthesized 932atccgtcaca cctgctctca ggcacatcga taagcattcg gaccagagtc gaaatggtgt 60tggctcccgt at 7293372DNAArtificial Sequencechemically synthesized 933atacgggagc caacaccatc tagtctgatt accggtgata agtgatcgaa gcggagagca 60ggtgtgacgg at 7293472DNAArtificial Sequencechemically synthesized 934atccgtcaca cctgctctcc gcttcgatca cttatcaccg gtaatcagac tagatggtgt 60tggctcccgt at 7293572DNAArtificial Sequencechemically synthesized 935atacgggagc

caacaccact cgagccaatg ctcatgagta agcgatctat ctccagagca 60ggtgtgacgg at 7293672DNAArtificial Sequencechemically synthesized 936atccgtcaca cctgctctgg agatagatcg cttactcatg agcattggct cgagtggtgt 60tggctcccgt at 7293772DNAArtificial Sequencechemically synthesized 937atacgggagc caacaccatt tcttcggtgt cctactgcac aattcccttc tttaagagca 60ggtgtgacgg at 7293872DNAArtificial Sequencechemically synthesized 938atccgtcaca cctgctctta aagaagggaa ttgtgcagta ggacaccgaa gaaatggtgt 60tggctcccgt at 7293972DNAArtificial Sequencechemically synthesized 939atacgggagc caacaccagg gtgtgagaga tagggtaaat ggtgtggcag ttagagagca 60ggtgtgacgg at 7294072DNAArtificial Sequencechemically synthesized 940atccgtcaca cctgctctct aactgccaca ccatttaccc tatctctcac accctggtgt 60tggctcccgt at 7294172DNAArtificial Sequencechemically synthesized 941atacgggagc caacaccaca catttgacgg ttttctctct gagattggca ttacagagca 60ggtgtgacgg at 7294272DNAArtificial Sequencechemically synthesized 942atccgtcaca cctgctctgt aatgccaatc tcagagagaa aaccgtcaaa tgtgtggtgt 60tggctcccgt at 7294371DNAArtificial Sequencechemically synthesized 943atacgggagc caacaccact acatgtctgt cacgtcccaa acgtgattgc gcaagagcag 60gtgtgacgga t 7194471DNAArtificial Sequencechemically synthesized 944atccgtcaca cctgctcttg cgcaatcacg tttgggacgt gacagacatg tagtggtgtt 60ggctcccgta t 7194572DNAArtificial Sequencechemically synthesized 945atacgggagc caacaccaac aggcagagtg gtgtagtgaa aatataattt gagtagagca 60ggtgtgacgg at 7294672DNAArtificial Sequencechemically synthesized 946atccgtcaca cctgctctac tcaaattata ttttcactac accactctgc ctgttggtgt 60tggctcccgt at 7294772DNAArtificial Sequencechemically synthesized 947atacgggagc caacaccagt tctaggcagt cgtcgctagt gagaaaaata cttcagagca 60ggtgtgacgg at 7294872DNAArtificial Sequencechemically synthesized 948atccgtcaca cctgctctga agtatttttc tcactagcga cgactgccta gaactggtgt 60tggctcccgt at 7294972DNAArtificial Sequencechemically synthesized 949atacgggagc caacaccatc cacaacgaac ttacatactc ccatcatact ctacagagca 60ggtgtgacgg at 7295072DNAArtificial Sequencechemically synthesized 950atccgtcaca cctgctctgt agagtatgat gggagtatgt aagttcgttg tggatggtgt 60tggctcccgt at 7295172DNAArtificial Sequencechemically synthesized 951atacgggagc caacaccatg tttaataatt tgcattgtac gacaggacgg agacagagca 60ggtgtgacgg at 7295272DNAArtificial Sequencechemically synthesized 952atccgtcaca cctgctctgt ctccgtcctg tcgtacaatg caaattatta aacatggtgt 60tggctcccgt at 7295371DNAArtificial Sequencechemically synthesized 953atacgggagc caacaccaca tggtttttgt aggataagga atagcttctt tccagagcag 60gtgtgacgga t 7195471DNAArtificial Sequencechemically synthesized 954atccgtcaca cctgctctgg aaagaagcta ttccttatcc tacaaaaacc atgtggtgtt 60ggctcccgta t 7195571DNAArtificial Sequencechemically synthesized 955atacgggagc caacaccagc aaccatcacc cacacgcacc cccctccacc tacagagcag 60gtgtgacgga t 7195671DNAArtificial Sequencechemically synthesized 956atccgtcaca cctgctctgt aggtggaggg gggtgcgtgt gggtgatggt tgctggtgtt 60ggctcccgta t 7195772DNAArtificial Sequencechemically synthesized 957atacgggagc caacaccaag tcaaacaacc ggaatgatca aataagtgtt atccagagca 60ggtgtgacgg at 7295872DNAArtificial Sequencechemically synthesized 958atccgtcaca cctgctctgg ataacactta tttgatcatt ccggttgttt gacttggtgt 60tggctcccgt at 7295972DNAArtificial Sequencechemically synthesized 959atacgggagc caacaccacc gttcattgat cataagagtg agaccgtata catgagagca 60ggtgtgacgg at 7296072DNAArtificial Sequencechemically synthesized 960atccgtcaca cctgctctca tgtatacggt ctcactctta tgatcaatga acggtggtgt 60tggctcccgt at 7296172DNAArtificial Sequencechemically synthesized 961atacgggagc caacaccaag agattagagg acacaaagga ggctatgtca aggtagagca 60ggtgtgacgg at 7296272DNAArtificial Sequencechemically synthesized 962atccgtcaca cctgctctac cttgacatag cctcctttgt gtcctctaat ctcttggtgt 60tggctcccgt at 7296372DNAArtificial Sequencechemically synthesized 963atacgggagc caacaccaca ctgcctacgt cgcccgcctt tccagccatc ctccagagca 60ggtgtgacgg at 7296472DNAArtificial Sequencechemically synthesized 964atccgtcaca cctgctctgg aggatggctg gaaaggcggg cgacgtaggc agtgtggtgt 60tggctcccgt at 7296572DNAArtificial Sequencechemically synthesized 965atacgggagc caacaccatg gagaatgggc caatcttgtt atacatgcat gagcagagca 60ggtgtgacgg at 7296672DNAArtificial Sequencechemically synthesized 966atccgtcaca cctgctctgc tcatgcatgt ataacaagat tggcccattc tccatggtgt 60tggctcccgt at 7296772DNAArtificial Sequencechemically synthesized 967atacgggagc caacaccata ttgtgacaat atatatatat ttagatagcg acgcagagca 60ggtgtgacgg at 7296872DNAArtificial Sequencechemically synthesized 968atccgtcaca cctgctctgc gtcgctatct aaatatatat atattgtcac aatatggtgt 60tggctcccgt at 7296972DNAArtificial Sequencechemically synthesized 969atacgggagc caacaccatg ggcaattgtt atttagaagg atgataataa ctggagagca 60ggtgtgacgg at 7297072DNAArtificial Sequencechemically synthesized 970atccgtcaca cctgctctcc agttattatc atccttctaa ataacaattg cccatggtgt 60tggctcccgt at 7297172DNAArtificial Sequencechemically synthesized 971atacgggagc caacaccacc cttgggacac aaattgttta ctgtaaaagt ccggagagca 60ggtgtgacgg at 7297272DNAArtificial Sequencechemically synthesized 972atccgtcaca cctgctctcc ggacttttac agtaaacaat ttgtgtccca agggtggtgt 60tggctcccgt at 7297371DNAArtificial Sequencechemically synthesized 973atacgggagc caacaccaca accgaacccc atgacccggc ccccataccc ggtgagagca 60ggtgtgacgg a 7197472DNAArtificial Sequencechemically synthesized 974atccgtcaca cctgctctca ccgggtatgg gggccgggtc atggggttcg gttgtggtgt 60tggctcccgt at 7297572DNAArtificial Sequencechemically synthesized 975atacgggagc caacaccagc aaacgaagat gttgattctc gagtgatagg aaggagagca 60ggtgtgacgg at 7297672DNAArtificial Sequencechemically synthesized 976atccgtcaca cctgctctcc ttcctatcac tcgagaatca acatcttcgt ttgctggtgt 60tggctcccgt at 7297772DNAArtificial Sequencechemically synthesized 977atacgggagc caacaccact tattgattag ttttcttata ataatacgag ggctagagca 60ggtgtgacgg at 7297872DNAArtificial Sequencechemically synthesized 978atccgtcaca cctgctctag ccctcgtatt attataagaa aactaatcaa taagtggtgt 60tggctcccgt at 7297972DNAArtificial Sequencechemically synthesized 979atacgggagc caacaccagg gaaggcaagt tgtgaaaata ttggtaggta tggcagagca 60ggtgtgacgg at 7298072DNAArtificial Sequencechemically synthesized 980atccgtcaca cctgctctgc catacctacc aatattttca caacttgcct tccctggtgt 60tggctcccgt at 7298172DNAArtificial Sequencechemically synthesized 981atacgggagc caacaccata gtggacggaa tgacaagtcg acggggggtg tgtgagagca 60ggtgtgacgg at 7298272DNAArtificial Sequencechemically synthesized 982atccgtcaca cctgctctca cacacccccc gtcgacttgt cattccgtcc actatggtgt 60tggctcccgt at 7298372DNAArtificial Sequencechemically synthesized 983atacgggagc caacaccaac agagttacaa agaaaaacgg taccaaccag ccccagagca 60ggtgtgacgg at 7298472DNAArtificial Sequencechemically synthesized 984atccgtcaca cctgctctgg ggctggttgg taccgttttt ctttgtaact ctgttggtgt 60tggctcccgt at 7298572DNAArtificial Sequencechemically synthesized 985atacgggagc caacaccatc ccggccctac agactgacta aagactgata atacagagca 60ggtgtgacgg at 7298672DNAArtificial Sequencechemically synthesized 986atccgtcaca cctgctctgt attatcagtc tttagtcagt ctgtagggcc gggatggtgt 60tggctcccgt at 7298772DNAArtificial Sequencechemically synthesized 987atacgggagc caacaccact ccatgaataa ctatgactcg ccctcaaccc tgtaagagca 60ggtgtgacgg at 7298872DNAArtificial Sequencechemically synthesized 988atccgtcaca cctgctctta cagggttgag ggcgagtcat agttattcat ggagtggtgt 60tggctcccgt at 7298972DNAArtificial Sequencechemically synthesized 989atacgggagc caacaccaaa caagattaaa gaattcatcg ccaacgtatc atgtagagca 60ggtgtgacgg at 7299072DNAArtificial Sequencechemically synthesized 990atccgtcaca cctgctctac atgatacgtt ggcgatgaat tctttaatct tgtttggtgt 60tggctcccgt at 7299172DNAArtificial Sequencechemically synthesized 991atacgggagc caacaccaca tagttatgaa acagaagcag taaccgggaa caatagagca 60ggtgtgacgg at 7299272DNAArtificial Sequencechemically synthesized 992atccgtcaca cctgctctat tgttcccggt tactgcttct gtttcataac tatgtggtgt 60tggctcccgt at 7299372DNAArtificial Sequencechemically synthesized 993atacgggagc caacaccaac acgctcactc ttcctacaca aactacaaca ccctagagca 60ggtgtgacgg at 7299472DNAArtificial Sequencechemically synthesized 994atccgtcaca cctgctctag ggtgttgtag tttgtgtagg aagagtgagc gtgttggtgt 60tggctcccgt at 7299572DNAArtificial Sequencechemically synthesized 995atacgggagc caacaccaag agctaagatt acacagcagt ctcaccacca ttacagagca 60ggtgtgacgg at 7299672DNAArtificial Sequencechemically synthesized 996atccgtcaca cctgctctcg ccccgatctc tagaatatta gtttcgagat aagatggtgt 60tggctcccgt at 7299772DNAArtificial Sequencechemically synthesized 997atacgggagc caacaccagg acaatagtgt tcaggaagga acggtccata cacgagagca 60ggtgtgacgg at 7299872DNAArtificial Sequencechemically synthesized 998atccgtcaca cctgctctcg tgtatggacc gttccttcct gaacactatt gtcctggtgt 60tggctcccgt at 7299971DNAArtificial Sequencechemically synthesized 999atacgggagc caacaccaca cagcacaacg gcttaaccac atctccgtac atgagagcag 60gtgtgacgga t 71100071DNAArtificial Sequencechemically synthesized 1000atccgtcaca cctgctctca tgtacggaga tgtggttaag ccgttgtgct gtgtggtgtt 60ggctcccgta t 71100172DNAArtificial Sequencechemically synthesized 1001atacgggagc caacaccaag acagaggtaa ttggtgaaat aaactaaatc atggagagca 60ggtgtgacgg at 72100272DNAArtificial Sequencechemically synthesized 1002atccgtcaca cctgctctcc atgatttagt ttatttcacc aattacctct gtcttggtgt 60tggctcccgt at 72100372DNAArtificial Sequencechemically synthesized 1003atacgggagc caacaccata gtctctactc gaattgcacc caacatgtct cagtagagca 60ggtgtgacgg at 72100472DNAArtificial Sequencechemically synthesized 1004atccgtcaca cctgctctac tgagacatgt tgggtgcaat tcgagtagag actatggtgt 60tggctcccgt at 72100572DNAArtificial Sequencechemically synthesized 1005atacgggagc caacaccatg ggataaacca taaagtctct gtgtaaactg cgcaagagca 60ggtgtgacgg at 72100672DNAArtificial Sequencechemically synthesized 1006atccgtcaca cctgctcttg cgcagtttac acagagactt tatggtttat cccatggtgt 60tggctcccgt at 72100772DNAArtificial Sequencechemically synthesized 1007atacgggagc caacaccact agttaggtct actgggtctg aaaaggtggt agtgagagca 60ggtgtgacgg at 72100872DNAArtificial Sequencechemically synthesized 1008atccgtcaca cctgctctca ctaccacctt ttcagaccca gtagacctaa ctagtggtgt 60tggctcccgt at 72100972DNAArtificial Sequencechemically synthesized 1009atacgggagc caacaccact aaactatact cagtgataaa gtcagaatgt gccgagagca 60ggtgtgacgg at 72101072DNAArtificial Sequencechemically synthesized 1010atccgtcaca cctgctctcg gcacattctg actttatcac tgagtatagt ttagtggtgt 60tggctcccgt at 72101172DNAArtificial Sequencechemically synthesized 1011atacgggagc caacaccacc acggactagt acattagaaa tcgcatacaa cagcagagca 60ggtgtgacgg at 72101272DNAArtificial Sequencechemically synthesized 1012atccgtcaca cctgctctgc tgttgtatgc gatttctaat gtactagtcc gtggtggtgt 60tggctcccgt at 72101372DNAArtificial Sequencechemically synthesized 1013atacgggagc caacaccaaa aaatctgagg ggaaaatttg accaagctga ctagagagca 60ggtgtgacgg at 72101472DNAArtificial Sequencechemically synthesized 1014atccgtcaca cctgctctct agtcagcttg gtcaaatttt cccctcagat tttttggtgt 60tggctcccgt at 72101571DNAArtificial Sequencechemically synthesized 1015atacgggagc caacaccacg tatgtggaag tcgaatcaaa aggcgacgac ctcagagcag 60gtgtgacgga t 71101671DNAArtificial Sequencechemically synthesized 1016atccgtcaca cctgctctga ggtcgtcgcc ttttgattcg acttccacat acgtggtgtt 60ggctcccgta t 71101772DNAArtificial Sequencechemically synthesized 1017atacgggagc caacaccagg gacatagtag ataggattga aaagtcgacc gttgagagca 60ggtgtgacgg at 72101872DNAArtificial Sequencechemically synthesized 1018atccgtcaca cctgctctca acggtcgact tttcaatcct atctactatg tccctggtgt 60tggctcccgt at

72101972DNAArtificial Sequencechemically synthesized 1019atacgggagc caacaccaat cccggacttc tcaacagaga tccctatctt accgagagca 60ggtgtgacgg at 72102072DNAArtificial Sequencechemically synthesized 1020atccgtcaca cctgctctcg gtaagatagg gatctctgtt gagaagtccg ggattggtgt 60tggctcccgt at 72102172DNAArtificial Sequencechemically synthesized 1021atacgggagc caacaccact gacggacccc cgggatggga caacctcatc taccagagca 60ggtgtgacgg at 72102272DNAArtificial Sequencechemically synthesized 1022atccgtcaca cctgctctgg tagatgaggt tgtcccatcc cgggggtccg tcagtggtgt 60tggctcccgt at 72102372DNAArtificial Sequencechemically synthesized 1023atacgggagc caacaccacg tcctgtgaaa ttgcgcggct atactagtgt ggtcagagca 60ggtgtgacgg at 72102472DNAArtificial Sequencechemically synthesized 1024atccgtcaca cctgctctga ccacactagt atagccgcgc aatttcacag gacgtggtgt 60tggctcccgt at 72102572DNAArtificial Sequencechemically synthesized 1025atacgggagc caacaccaca atggcgacac tcctgacctg ttgagtggtt ttatagagca 60ggtgtgacgg at 72102672DNAArtificial Sequencechemically synthesized 1026atccgtcaca cctgctctat aaaaccactc aacaggtcag gagtgtcgcc attgtggtgt 60tggctcccgt at 72102772DNAArtificial Sequencechemically synthesized 1027atacgggagc caacaccaac cataaaacca caaaatataa attccaaacc ccagagagca 60ggtgtgacgg at 72102872DNAArtificial Sequencechemically synthesized 1028atccgtcaca cctgctctct ggggtttgga atttatattt tgtggtttta tggttggtgt 60tggctcccgt at 72102972DNAArtificial Sequencechemically synthesized 1029atacgggagc caacaccatc tctcttagga tacaaagcca aactgagccc gtgcagagca 60ggtgtgacgg at 72103072DNAArtificial Sequencechemically synthesized 1030atccgtcaca cctgctctgc acgggctcag tttggctttg tatcctaaga gagatggtgt 60tggctcccgt at 72103172DNAArtificial Sequencechemically synthesized 1031atacgggagc caacaccact taagcggtgt actataactg agataggagt gagcagagca 60ggtgtgacgg at 72103272DNAArtificial Sequencechemically synthesized 1032atccgtcaca cctgctctgc tcactcctat ctcagttata gtacaccgct taagtggtgt 60tggctcccgt at 72103372DNAArtificial Sequencechemically synthesized 1033atacgggagc caacaccaac tctcccttcc ttcttcccac cctccctctc gtccagagca 60ggtgtgacgg at 72103472DNAArtificial Sequencechemically synthesized 1034atccgtcaca cctgctctgg acgagaggga gggtgggaag aaggaaggga gagttggtgt 60tggctcccgt at 72103572DNAArtificial Sequencechemically synthesized 1035atacgggagc caacaccact tgaacgatgc cgcggccttt ggatctgtgg tgggagagca 60ggtgtgacgg at 72103672DNAArtificial Sequencechemically synthesized 1036atccgtcaca cctgctctcc caccacagat ccaaaggccg cggcatcgtt caagtggtgt 60tggctcccgt at 72103772DNAArtificial Sequencechemically synthesized 1037atacgggagc caacaccact aacggctaca ctattcctta gacctcccct ctgtagagca 60ggtgtgacgg at 72103872DNAArtificial Sequencechemically synthesized 1038atccgtcaca cctgctctac agaggggagg tctaaggaat agtgtagccg ttagtggtgt 60tggctcccgt at 72103972DNAArtificial Sequencechemically synthesized 1039atacgggagc caacaccaac tagtaacggt tctgattcct aaatattttt ccacagagca 60ggtgtgacgg at 72104072DNAArtificial Sequencechemically synthesized 1040atccgtcaca cctgctctgt ggaaaaatat ttaggaatca gaaccgttac tagttggtgt 60tggctcccgt at 72104172DNAArtificial Sequencechemically synthesized 1041atacgggagc caacaccata tagtgttata taaacaaagg aatagaaatt ggtgagagca 60ggtgtgacgg at 72104272DNAArtificial Sequencechemically synthesized 1042atccgtcaca cctgctctca ccaatttcta ttcctttgtt tatataacac tatatggtgt 60tggctcccgt at 72104372DNAArtificial Sequencechemically synthesized 1043atacgggagc caacaccacc atatatcaac attcaaccgc tttttctacg acccagagca 60ggtgtgacgg at 72104472DNAArtificial Sequencechemically synthesized 1044atccgtcaca cctgctctgg gtcgtagaaa aagcggttga atgttgatat atggtggtgt 60tggctcccgt at 72104572DNAArtificial Sequencechemically synthesized 1045atacgggagc caacaccata tttatagtac aagaaaaaca ccatggacgt gtacagagca 60ggtgtgacgg at 72104672DNAArtificial Sequencechemically synthesized 1046atccgtcaca cctgctctgt acacgtccat ggtgtttttc ttgtactata aatatggtgt 60tggctcccgt at 72104772DNAArtificial Sequencechemically synthesized 1047atacgggagc caacaccatt gttactatta acatatcagt ggcggatgtt cacgagagca 60ggtgtgacgg at 72104872DNAArtificial Sequencechemically synthesized 1048atccgtcaca cctgctctcg tgaacatccg ccactgatat gttaatagta acaatggtgt 60tggctcccgt at 72104972DNAArtificial Sequencechemically synthesized 1049atacgggagc caacaccaga atgaatttat gaataaggaa ggctggagag ccctagagca 60ggtgtgacgg at 72105072DNAArtificial Sequencechemically synthesized 1050atccgtcaca cctgctctag ggctctccag ccttccttat tcataaattc attctggtgt 60tggctcccgt at 72105172DNAArtificial Sequencechemically synthesized 1051atacgggagc caacaccata agataaaggt agacgtaata tagtaactat atacagagca 60ggtgtgacgg at 72105272DNAArtificial Sequencechemically synthesized 1052atccgtcaca cctgctctgt atatagttac tatattacgt ctacctttat cttatggtgt 60tggctcccgt at 72105372DNAArtificial Sequencechemically synthesized 1053atacgggagc caacaccata cgtgtttata attacactga atgaataaga tagtagagca 60ggtgtgacgg at 72105472DNAArtificial Sequencechemically synthesized 1054atccgtcaca cctgctctac tatcttattc attcagtgta attataaaca cgtatggtgt 60tggctcccgt at 72105571DNAArtificial Sequencechemically synthesized 1055atacgggagc caacaccaca tcaaaattat tattgtcctg tatggagtta gacagagcag 60gtgtgacgga t 71105671DNAArtificial Sequencechemically synthesized 1056atccgtcaca cctgctctgt ctaactccat acaggacaat aataattttg atgtggtgtt 60ggctcccgta t 71105772DNAArtificial Sequencechemically synthesized 1057atacgggagc caacaccata acccaaaagg gcgggggatg tattacttag caccagagca 60ggtgtgacgg at 72105872DNAArtificial Sequencechemically synthesized 1058atccgtcaca cctgctctgg tgctaagtaa tacatccccc gcccttttgg gttatggtgt 60tggctcccgt at 72105972DNAArtificial Sequencechemically synthesized 1059atacgggagc caacaccata tgatttacta ctttacagag gaagctcgtg ttgcagagca 60ggtgtgacgg at 72106072DNAArtificial Sequencechemically synthesized 1060atccgtcaca cctgctctgc aacacgagct tcctctgtaa agtagtaaat catatggtgt 60tggctcccgt at 72106172DNAArtificial Sequencechemically synthesized 1061atacgggagc caacaccacc acctatcgac ttttgcactg gaccctagct ccccagagca 60ggtgtgacgg at 72106272DNAArtificial Sequencechemically synthesized 1062atccgtcaca cctgctctgg ggagctaggg tccagtgcaa aagtcgatag gtggtggtgt 60tggctcccgt at 72106372DNAArtificial Sequencechemically synthesized 1063atacgggagc caacaccact aatcaaatct taggacgttc aaggtaagat cggcagagca 60ggtgtgacgg at 72106472DNAArtificial Sequencechemically synthesized 1064atccgtcaca cctgctctgc cgatcttacc ttgaacgtcc taagatttga ttagtggtgt 60tggctcccgt at 72106568DNAArtificial Sequencechemically synthesized 1065atacgggagc caacaccatc tagaaaaagg aacgagcctt ccacatgtcc agagcaggtg 60tgacggat 68106668DNAArtificial Sequencechemically synthesized 1066atccgtcaca cctgctctgg acatgtggaa ggctcgttcc tttttctaga tggtgttggc 60tcccgtat 68106771DNAArtificial Sequencechemically synthesized 1067atacgggagc caacaccact actctcccgc gccccgttgc ccccccataa ccaagagcag 60gtgtgacgga t 71106871DNAArtificial Sequencechemically synthesized 1068atccgtcaca cctgctcttg gttatggggg ggcaacgggg cgcgggagag tagtggtgtt 60ggctcccgta t 71106972DNAArtificial Sequencechemically synthesized 1069atacgggagc caacaccatt tgtatagaat aacagcaatt acattccaca acccagagca 60ggtgtgacgg at 72107072DNAArtificial Sequencechemically synthesized 1070atccgtcaca cctgctctgg gttgtggaat gtaattgctg ttattctata caaatggtgt 60tggctcccgt at 72107172DNAArtificial Sequencechemically synthesized 1071atacgggagc caacaccagc ataaattgta tatagtggta cccttttttc atggagagca 60ggtgtgacgg at 72107272DNAArtificial Sequencechemically synthesized 1072atccgtcaca cctgctctcc atgaaaaaag ggtaccacta tatacaattt atgctggtgt 60tggctcccgt at 72107372DNAArtificial Sequencechemically synthesized 1073atacgggagc caacaccaca tcttctcgcc ctccccccgc cgccccggaa cccgagagca 60ggtgtgacgg at 72107472DNAArtificial Sequencechemically synthesized 1074atccgtcaca cctgctctcg ggttccgggg cggcgggggg agggcgagaa gatgtggtgt 60tggctcccgt at 72107572DNAArtificial Sequencechemically synthesized 1075atacgggagc caacaccaga cgaacatata taacaattcg ttaatggatg cgtcagagca 60ggtgtgacgg at 72107672DNAArtificial Sequencechemically synthesized 1076atccgtcaca cctgctctga cgcatccatt aacgaattgt tatatatgtt cgtctggtgt 60tggctcccgt at 72107772DNAArtificial Sequencechemically synthesized 1077atacgggagc caacaccacg actgccaccg aattacttaa actcatttag agcgagagca 60ggtgtgacgg at 72107872DNAArtificial Sequencechemically synthesized 1078atccgtcaca cctgctctcg ctctaaatga gtttaagtaa ttcggtggca gtcgtggtgt 60tggctcccgt at 72107972DNAArtificial Sequencechemically synthesized 1079atacgggagc caacaccacc caacaaacta ctcacccatc ctaatcaacc ttcgagagca 60ggtgtgacgg at 72108072DNAArtificial Sequencechemically synthesized 1080atccgtcaca cctgctctcg aaggttgatt aggatgggtg agtagtttgt tgggtggtgt 60tggctcccgt at 72108172DNAArtificial Sequencechemically synthesized 1081atacgggagc caacaccagg gagagagaac gtacccgaac tttttcttac tgagagagca 60ggtgtgacgg at 72108272DNAArtificial Sequencechemically synthesized 1082atccgtcaca cctgctctct cagtaagaaa aagttcgggt acgttctctc tccctggtgt 60tggctcccgt at 72108372DNAArtificial Sequencechemically synthesized 1083atacgggagc caacaccacg cacacttcac caatacgatc cagcccggaa tgatagagca 60ggtgtgacgg at 72108472DNAArtificial Sequencechemically synthesized 1084atccgtcaca cctgctctat cattccgggc tggatcgtat tggtgaagtg tgcgtggtgt 60tggctcccgt at 72108572DNAArtificial Sequencechemically synthesized 1085atacgggagc caacaccatc gcagcaatct attcttagat ctcctatttc gtcaagagca 60ggtgtgacgg at 72108672DNAArtificial Sequencechemically synthesized 1086atccgtcaca cctgctcttg acgaaatagg agatctaaga atagattgct gcgatggtgt 60tggctcccgt at 72108772DNAArtificial Sequencechemically synthesized 1087atacgggagc caacaccagt aaatatcaaa tccctatcct cctccttcga taggagagca 60ggtgtgacgg at 72108872DNAArtificial Sequencechemically synthesized 1088atccgtcaca cctgctctcc tatcgaagga ggaggatagg gatttgatat ttactggtgt 60tggctcccgt at 72108972DNAArtificial Sequencechemically synthesized 1089atacgggagc caacaccacc ccaggtttgc ccgcctatat cgcattcgtc ctctagagca 60ggtgtgacgg at 72109072DNAArtificial Sequencechemically synthesized 1090atccgtcaca cctgctctag aggacgaatg cgatataggc gggcaaacct ggggtggtgt 60tggctcccgt at 72109172DNAArtificial Sequencechemically synthesized 1091atacgggagc caacaccatc gtgtactatt cctgtgggtg gacactacag ggccagagca 60ggtgtgacgg at 72109272DNAArtificial Sequencechemically synthesized 1092atccgtcaca cctgctctgg ccctgtagtg tccacccaca ggaatagtac acgatggtgt 60tggctcccgt at 72109372DNAArtificial Sequencechemically synthesized 1093atacgggagc caacaccacc tctcccacac cagcccagcc cccgcgccat tccaagagca 60ggtgtgacgg at 72109472DNAArtificial Sequencechemically synthesized 1094atccgtcaca cctgctcttg gaatggcgcg ggggctgggc tggtgtggga gaggtggtgt 60tggctcccgt at 72109572DNAArtificial Sequencechemically synthesized 1095atacgggagc caacaccagt gtaagtgttg attgtctttt ttgtgaatta gcggagagca 60ggtgtgacgg at 72109672DNAArtificial Sequencechemically synthesized 1096atccgtcaca cctgctctcc gctaattcac aaaaaagaca atcaacactt acactggtgt 60tggctcccgt at 72109772DNAArtificial Sequencechemically synthesized 1097atacgggagc caacaccacg tgacaattat ccatacgccg cgcaatccgc tgttagagca 60ggtgtgacgg at 72109872DNAArtificial Sequencechemically synthesized 1098atccgtcaca cctgctctaa cagcggattg cgcggcgtat ggataattgt cacgtggtgt 60tggctcccgt at 72109972DNAArtificial Sequencechemically synthesized 1099atacgggagc caacaccacc cctaagttcg ttgcaacata ccccaggcac tcttagagca 60ggtgtgacgg at 72110072DNAArtificial Sequencechemically synthesized 1100atccgtcaca cctgctctaa gagtgcctgg ggtatgttgc aacgaactta ggggtggtgt 60tggctcccgt at 72110172DNAArtificial Sequencechemically synthesized 1101atacgggagc caacaccagc cagcgacgag gtgtatagag gtgaggttac tttgagagca 60ggtgtgacgg at 72110272DNAArtificial Sequencechemically synthesized 1102atccgtcaca cctgctctca aagtaacctc acctctatac acctcgtcgc tggctggtgt 60tggctcccgt

at 72110372DNAArtificial Sequencechemically synthesized 1103atacgggagc caacaccaat cgttagttat aacagcacga cgactggata gtggagagca 60ggtgtgacgg at 72110472DNAArtificial Sequencechemically synthesized 1104atccgtcaca cctgctctcc actatccagt cgtcgtgctg ttataactaa cgattggtgt 60tggctcccgt at 72110572DNAArtificial Sequencechemically synthesized 1105atacgggagc caacaccagt ccgttatgac atgtccggac ccgtacgcgt gtcaagagca 60ggtgtgacgg at 72110672DNAArtificial Sequencechemically synthesized 1106atccgtcaca cctgctcttg acacgcgtac gggtccggac atgtcataac ggactggtgt 60tggctcccgt at 72110772DNAArtificial Sequencechemically synthesized 1107atacgggagc caacaccata acgagatagg tgagcctgaa atagtgggtt atgcagagca 60ggtgtgacgg at 72110872DNAArtificial Sequencechemically synthesized 1108atccgtcaca cctgctctgc ataacccact atttcaggct cacctatctc gttatggtgt 60tggctcccgt at 72110972DNAArtificial Sequencechemically synthesized 1109atacgggagc caacaccagg ttactggtca cgatcaaagc tggtaattaa tgtgagagca 60ggtgtgacgg at 72111072DNAArtificial Sequencechemically synthesized 1110atccgtcaca cctgctctca cattaattac cagctttgat cgtgaccagt aacctggtgt 60tggctcccgt at 72111172DNAArtificial Sequencechemically synthesized 1111atacgggagc caacaccagc gagataaata gccagcccaa aaccggcgaa gtacagagca 60ggtgtgacgg at 72111272DNAArtificial Sequencechemically synthesized 1112atccgtcaca cctgctctgt acttcgccgg ttttgggctg gctatttatc tcgctggtgt 60tggctcccgt at 72111372DNAArtificial Sequencechemically synthesized 1113atacgggagc caacaccatg gacaccagcc tttccggcat gatatccacc ctcaagagca 60ggtgtgacgg at 72111472DNAArtificial Sequencechemically synthesized 1114atccgtcaca cctgctcttg agggtggata tcatgccgga aaggctggtg tccatggtgt 60tggctcccgt at 72111572DNAArtificial Sequencechemically synthesized 1115atacgggagc caacaccaca tatgtctggg cagacgatga agagagacaa caagagagca 60ggtgtgacgg at 72111672DNAArtificial Sequencechemically synthesized 1116atccgtcaca cctgctctct tgttgtctct cttcatcgtc tgcccagaca tatgtggtgt 60tggctcccgt at 72111772DNAArtificial Sequencechemically synthesized 1117atacgggagc caacaccacg ttaagtaacg acaggcaaat atgacactaa tgctagagca 60ggtgtgacgg at 72111872DNAArtificial Sequencechemically synthesized 1118atccgtcaca cctgctctag cattagtgtc atatttgcct gtcgttactt aacgtggtgt 60tggctcccgt at 72111972DNAArtificial Sequencechemically synthesized 1119atacgggagc caacaccatc gatgtatgca tccaccccgg acatcccgct cacgagagca 60ggtgtgacgg at 72112072DNAArtificial Sequencechemically synthesized 1120atccgtcaca cctgctctcg tgagcgggat gtccggggtg gatgcataca tcgatggtgt 60tggctcccgt at 72112172DNAArtificial Sequencechemically synthesized 1121atacgggagc caacaccagg atggaacgaa catacagatc gagttgtatt taccagagca 60ggtgtgacgg at 72112272DNAArtificial Sequencechemically synthesized 1122atccgtcaca cctgctctgg taaatacaac tcgatctgta tgttcgttcc atcctggtgt 60tggctcccgt at 72112372DNAArtificial Sequencechemically synthesized 1123atacgggagc caacaccacc ctgcccggca ccccagtggg ccgtcgaccc aacgagagca 60ggtgtgacgg at 72112472DNAArtificial Sequencechemically synthesized 1124atccgtcaca cctgctctcg ttgggtcgac ggcccactgg ggtgccgggc agggtggtgt 60tggctcccgt at 72112572DNAArtificial Sequencechemically synthesized 1125atacgggagc caacaccata tatgaataac tcgcctaagt aacgcaagca gtatagagca 60ggtgtgacgg at 72112672DNAArtificial Sequencechemically synthesized 1126atccgtcaca cctgctctat actgcttgcg ttacttaggc gagttattca tatatggtgt 60tggctcccgt at 72112768DNAArtificial Sequencechemically synthesized 1127atacgggagc caacaccaat tcaaatcttc acatcatcaa cgttgtgcac agagcaggtg 60tgacggat 68112868DNAArtificial Sequencechemically synthesized 1128atccgtcaca cctgctctgt gcacaacgtt gatgatgtga agatttgaat tggtgttggc 60tcccgtat 68112958DNAArtificial Sequencechemically synthesized 1129atacgggagc caacaccaca tgactgcgcc ctacacttgc agagcaggtg tgacggat 58113058DNAArtificial Sequencechemically synthesized 1130atccgtcaca cctgctctgc aagtgtaggg cgcagtcatg tggtgttggc tcccgtat 58113172DNAArtificial Sequencechemically synthesized 1131atacgggagc caacaccaac cactactcgt tttaggaagc gttccaaacg gagcagagca 60ggtgtgacgg at 72113272DNAArtificial Sequencechemically synthesized 1132atccgtcaca cctgctctgc tccgtttgga acgcttccta aaacgagtag tggttggtgt 60tggctcccgt at 72113372DNAArtificial Sequencechemically synthesized 1133atacgggagc caacaccagt ccgttatgac atgtccggac ccgtacgcgt gtcaagagca 60ggtgtgacgg at 72113472DNAArtificial Sequencechemically synthesized 1134atccgtcaca cctgctcttg acacgcgtac gggtccggac atgtcataac ggactggtgt 60tggctcccgt at 72113572DNAArtificial Sequencechemically synthesized 1135atacgggagc caacaccaca agacccaaag acgggtcgtg accccgattt gctgagagca 60ggtgtgacgg at 72113672DNAArtificial Sequencechemically synthesized 1136atccgtcaca cctgctctca gcaaatcggg gtcacgaccc gtctttgggt cttgtggtgt 60tggctcccgt at 72113772DNAArtificial Sequencechemically synthesized 1137atacgggagc caacaccatg cattacagac ctaaaaagaa aagatcgccg aaaaagagca 60ggtgtgacgg at 72113872DNAArtificial Sequencechemically synthesized 1138atccgtcaca cctgctcttt ttcggcgatc ttttcttttt aggtctgtaa tgcatggtgt 60tggctcccgt at 72113971DNAArtificial Sequencechemically synthesized 1139atacgggagc caacaccagt ccgttatgac atgtcggacc cgtacgcgtg tcaagagcag 60gtgtgacgga t 71114071DNAArtificial Sequencechemically synthesized 1140atccgtcaca cctgctcttg acacgcgtac gggtccgaca tgtcataacg gactggtgtt 60ggctcccgta t 71114172DNAArtificial Sequencechemically synthesized 1141atacgggagc caacaccagg tgacattcat ctaggaaact tgaatgtgag atatagagca 60ggtgtgacgg at 72114272DNAArtificial Sequencechemically synthesized 1142atccgtcaca cctgctctat atctcacatt caagtttcct agatgaatgt cacctggtgt 60tggctcccgt at 72114372DNAArtificial Sequencechemically synthesized 1143atacgggagc caacaccaaa gcgtgttgct ggacagattc agacatagga acttagagca 60ggtgtgacgg at 72114472DNAArtificial Sequencechemically synthesized 1144atccgtcaca cctgctctaa gttcctatgt ctgaatctgt ccagcaacac gctttggtgt 60tggctcccgt at 72114572DNAArtificial Sequencechemically synthesized 1145atacgggagc caacaccatt aacaaatgat aagttaggat tctgaacact tggcagagca 60ggtgtgacgg at 72114672DNAArtificial Sequencechemically synthesized 1146atccgtcaca cctgctctgc caagtgttca gaatcctaac ttatcatttg ttaatggtgt 60tggctcccgt at 72114772DNAArtificial Sequencechemically synthesized 1147atacgggagc caacaccacg ggtgagttaa taaatgtggg tcactccgtc caacagagca 60ggtgtgacgg at 72114872DNAArtificial Sequencechemically synthesized 1148atccgtcaca cctgctctgt tggacggagt gacccacatt tattaactca cccgtggtgt 60tggctcccgt at 72114972DNAArtificial Sequencechemically synthesized 1149atacgggagc caacaccatg aatgcaatgt attagagcga tgaaatcatt atttagagca 60ggtgtgacgg at 72115072DNAArtificial Sequencechemically synthesized 1150atccgtcaca cctgctctaa ataatgattt catcgctcta atacattgca ttcatggtgt 60tggctcccgt at 72115172DNAArtificial Sequencechemically synthesized 1151atacgggagc caacaccaat agggttaaac gaactggaca aggcggtgct atcgagagca 60ggtgtgacgg at 72115272DNAArtificial Sequencechemically synthesized 1152atccgtcaca cctgctctcg atagcaccgc cttgtccagt tcgtttaacc ctattggtgt 60tggctcccgt at 72115372DNAArtificial Sequencechemically synthesized 1153atacgggagc caacaccaat atcgttagaa gtttgtaaag tatccttcga tataagagca 60ggtgtgacgg at 72115472DNAArtificial Sequencechemically synthesized 1154atccgtcaca cctgctctta tatcgaagga tactttacaa acttctaacg atattggtgt 60tggctcccgt at 72115572DNAArtificial Sequencechemically synthesized 1155atacgggagc caacaccata taagtaccac cataacgaag tgagtggaat gaacagagca 60ggtgtgacgg at 72115672DNAArtificial Sequencechemically synthesized 1156atccgtcaca cctgctctgt tcattccact cacttcgtta tggtggtact tatatggtgt 60tggctcccgt at 72115772DNAArtificial Sequencechemically synthesized 1157atacgggagc caacaccacc tcctaccccc aaccccggtc cccgtaaatg tactagagca 60ggtgtgacgg at 72115872DNAArtificial Sequencechemically synthesized 1158atccgtcaca cctgctctag tacatttacg gggaccgggg ttgggggtag gaggtggtgt 60tggctcccgt at 72115972DNAArtificial Sequencechemically synthesized 1159atacgggagc caacaccatg attgaatagg tggaattagg taagtaaccg acctagagca 60ggtgtgacgg at 72116072DNAArtificial Sequencechemically synthesized 1160atccgtcaca cctgctctag gtcggttact tacctaattc cacctattca atcatggtgt 60tggctcccgt at 72116172DNAArtificial Sequencechemically synthesized 1161atacgggagc caacaccagc caagcccagc cctcccttct cctctctctc cctcagagca 60ggtgtgacgg at 72116272DNAArtificial Sequencechemically synthesized 1162atccgtcaca cctgctctga gggagagaga ggagaaggga gggctgggct tggctggtgt 60tggctcccgt at 72116372DNAArtificial Sequencechemically synthesized 1163atacgggagc caacaccatc tagcaagacg tacgtagata aggttattcc cacaagagca 60ggtgtgacgg at 72116472DNAArtificial Sequencechemically synthesized 1164atccgtcaca cctgctcttg tgggaataac cttatctacg tacgtcttgc tagatggtgt 60tggctcccgt at 72116572DNAArtificial Sequencechemically synthesized 1165atacgggagc caacaccaga cgatatgacc gtagttcggc gacactctat ggggagagca 60ggtgtgacgg at 72116672DNAArtificial Sequencechemically synthesized 1166atccgtcaca cctgctctcc ccatagagtg tcgccgaact acggtcatat cgtctggtgt 60tggctcccgt at 72116772DNAArtificial Sequencechemically synthesized 1167atacgggagc caacaccaca gaccccctca tcccgccggc agcccccttt gccgagagca 60ggtgtgacgg at 72116872DNAArtificial Sequencechemically synthesized 1168atccgtcaca cctgctctcg gcaaaggggg ctgccggcgg gatgaggggg tctgtggtgt 60tggctcccgt at 72116972DNAArtificial Sequencechemically synthesized 1169atacgggagc caacaccaac cccactaagt cccctatcat ttaagatgcc ctaaagagca 60ggtgtgacgg at 72117072DNAArtificial Sequencechemically synthesized 1170atccgtcaca cctgctcttt agggcatctt aaatgatagg ggacttagtg gggttggtgt 60tggctcccgt at 72117172DNAArtificial Sequencechemically synthesized 1171atacgggagc caacaccaga caacccttct acccctcaag tcgccaataa cggtagagca 60ggtgtgacgg at 72117272DNAArtificial Sequencechemically synthesized 1172atccgtcaca cctgctctac cgttattggc gacttgaggg gtagaagggt tgtctggtgt 60tggctcccgt at 72117372DNAArtificial Sequencechemically synthesized 1173atacgggagc caacaccagg tttaaagatt cattcgcagc tcaaatatct ttggagagca 60ggtgtgacgg at 72117472DNAArtificial Sequencechemically synthesized 1174atccgtcaca cctgctctcc aaagatattt gagctgcgaa tgaatcttta aacctggtgt 60tggctcccgt at 72117572DNAArtificial Sequencechemically synthesized 1175atacgtgagc caacaccata aatagaaagc caagagaggt tagggttaat gagtagagca 60ggtgtgacgg at 72117672DNAArtificial Sequencechemically synthesized 1176atccgtcaca cctgctctac tcattaaccc taacctctct tggctttcta tttatggtgt 60tggctcacgt at 72117772DNAArtificial Sequencechemically synthesized 1177atacgggagc caacaccacc caccttccct cttcatacgc cacctcacac atccagagca 60ggtgtgacgg at 72117872DNAArtificial Sequencechemically synthesized 1178atccgtcaca cctgctctgg atgtgtgagg tggcgtatga agagggaagg tgggtggtgt 60tggctcccgt at 72117972DNAArtificial Sequencechemically synthesized 1179atacgggagc caacaccaag tccgaaagaa cttataacgc aatggaatcc tgggagagca 60ggtgtgacgg at 72118072DNAArtificial Sequencechemically synthesized 1180atccgtcaca cctgctctcc caggattcca ttgcgttata agttctttcg gacttggtgt 60tggctcccgt at 72118172DNAArtificial Sequencechemically synthesized 1181atacgggagc caacaccaga attacactct ggtggggtgg gggaagaggg atgtagagca 60ggtgtgacgg at 72118272DNAArtificial Sequencechemically synthesized 1182atccgtcaca cctgctctac atccctcttc ccccacccca ccagagtgta attctggtgt 60tggctcccgt at 72118372DNAArtificial Sequencechemically synthesized 1183atacgggagc caacaccaaa acaacacaat acgccctata gcgaaagaca acgtagagca 60ggtgtgacgg at 72118472DNAArtificial Sequencechemically synthesized 1184atccgtcaca cctgctctac gttgtctttc gctatagggc gtattgtgtt gttttggtgt 60tggctcccgt at 72118572DNAArtificial Sequencechemically synthesized 1185atacgggagc caacaccatc tttcttagga tacaaagcca aactgagccc gtgcagagca 60ggtgtgacgg at 72118672DNAArtificial Sequencechemically synthesized 1186atccgtcaca cctgctctgc acgggctcag tttggctttg tatcctaaga aagatggtgt 60tggctcccgt at

72118772DNAArtificial Sequencechemically synthesized 1187atacgggagc caacaccacg acattattat tgtatcatgt acggtagcct tttgagagca 60ggtgtgacgg at 72118872DNAArtificial Sequencechemically synthesized 1188atccgtcaca cctgctctca aaaggctacc gtacatgata caataataat gtcgtggtgt 60tggctcccgt at 72118972DNAArtificial Sequencechemically synthesized 1189atacgggagc caacaccaac gttccagctc aaagactctt ttctaaaacg gtgtagagca 60ggtgtgacgg at 72119072DNAArtificial Sequencechemically synthesized 1190atccgtcaca cctgctctac accgttttag aaaagagtct ttgagctgga acgttggtgt 60tggctcccgt at 72119172DNAArtificial Sequencechemically synthesized 1191atacgggagc caacaccacc aaaaacccct accccacacc agacttcccc cgccagagca 60ggtgtgacgg at 72119272DNAArtificial Sequencechemically synthesized 1192atccgtcaca cctgctctgg cgggggaagt ctggtgtggg gtaggggttt ttggtggtgt 60tggctcccgt at 72119372DNAArtificial Sequencechemically synthesized 1193atacgggagc caacaccaat aattaaaaat aagatagaaa gaacatgtca gtctagagca 60ggtgtgacgg at 72119472DNAArtificial Sequencechemically synthesized 1194atccgtcaca cctgctctag actgacatgt tctttctatc ttatttttaa ttattggtgt 60tggctcccgt at 72119569DNAArtificial Sequencechemically synthesized 1195atacgggagc caacaccaga gcaggtgtga cggagagcag gtgtgacggg tagagcaggt 60gtgacggat 69119669DNAArtificial Sequencechemically synthesized 1196atccgtcaca cctgctctac ccgtcacacc tgctctccgt cacacctgct ctggtgttgg 60ctcccgtat 69119772DNAArtificial Sequencechemically synthesized 1197atacgggagc caacaccata ctgtttaggc gagttcgcta ttttcctcca tgatagagca 60ggtgtgacgg at 72119872DNAArtificial Sequencechemically synthesized 1198atccgtcaca cctgctctat catggaggaa aatagcgaac tcgcctaaac agtatggtgt 60tggctcccgt at 72119972DNAArtificial Sequencechemically synthesized 1199atacgggagc caacaccacg tccgtctatt cccggtcttc ctcctccctt gaccagagca 60ggtgtgacgg at 72120072DNAArtificial Sequencechemically synthesized 1200atccgtcaca cctgctctgg tcaagggagg aggaagaccg ggaatagacg gacgtggtgt 60tggctcccgt at 72120172DNAArtificial Sequencechemically synthesized 1201atacgggagc caacaccatg ggggaaatgg ggatgcagta aattacatga gtgcagagca 60ggtgtgacgg at 72120272DNAArtificial Sequencechemically synthesized 1202atccgtcaca cctgctctgc actcatgtaa tttactgcat ccccatttcc cccatggtgt 60tggctcccgt at 72120372DNAArtificial Sequencechemically synthesized 1203atacgggagc caacaccatc tctcttagga tacaaagcca aactgagccc gtgcagagca 60ggtgtgacgg at 72120472DNAArtificial Sequencechemically synthesized 1204atccgtcaca cctgctctgc acgggctcag tttggctttg tatcctaaga gagatggtgt 60tggctcccgt at 72120572DNAArtificial Sequencechemically synthesized 1205atacgggagc caacaccacg tcaactaagc gagaattcag aaagctgttt gaccagagca 60ggtgtgacgg at 72120672DNAArtificial Sequencechemically synthesized 1206atccgtcaca cctgctctgg tcaaacagct ttctgaattc tcgcttagtt gacgtggtgt 60tggctcccgt at 72120772DNAArtificial Sequencechemically synthesized 1207atacgggagc caacaccacc ccctccgctt tactctccca cactgcccta tcacagagca 60ggtgtgacgg at 72120872DNAArtificial Sequencechemically synthesized 1208atccgtcaca cctgctctgt gatagggcag tgtgggagag taaagcggag ggggtggtgt 60tggctcccgt at 72

Claims

1. A DNA ligand sequence consisting of a nucleic acid sequence selected from SEQ ID NOS: 1-650.

2. A composition comprising the DNA ligand sequence of claim 1.

3. The composition of claim 2, wherein said aptamer is capable of binding to a targeted waterborne or foodborne pathogenic bacteria.

4. The composition of claim 2, wherein said aptamer is capable of binding to a targeted waterborne or foodborne pathogenic toxin.

5. The composition of claim 3, being capable of use for detecting said targeted bacteria, wherein said targeted bacteria is present in a sample with at least 10 bacteria per mL.

6. The composition of claim 3, being capable of use for quantifying the number of said targeted bacteria in a sample.

7. The DNA ligand sequence of claim 1, capable of being used for at least one of the assay types: ELISA-like, lateral flow test strip, chemiluminescence, electrochemiluminescence, fluorescence (intensity, lifetime, FP, FRET beacons or competitive FRET), magnetic bead capture, membrane blotting (including dot or slot blotting and the DNA ligand-based analog to "Western" blotting), surface plasmon resonance, plastic-adherent, or radioisotopic detection in food and water samples in tubes, cuvettes or on flat surfaces such as membranes or plastic or glass biochips.

8. The DNA ligand sequence of claim 9 wherein the target is Campylobacter jejuni or a closely related species such as C. coli or C. lari and the DNA ligand sequences are selected from SEQ ID NO's. 1-58.

9. The DNA ligand sequence of claim 9 wherein the target is a pathogenic strain of Escherichia coli and the DNA ligand sequences are selected from SEQ ID NO's. 67-224.

10. The DNA ligand sequence of claim 9 wherein the target is a strain of Listeria monocytogenes or a related species and the DNA ligand sequences are selected from SEQ ID NO's. 279-380.

11. The DNA ligand sequence of claim 9 wherein the target is a strain of Salmonella enterica serovar Typhimurium (formerly Salmonella typhimurium) or a related species and the DNA ligand sequences are selected from SEQ ID NO's. 405-543.

12. The DNA ligand sequence of claim 9 wherein the target is Shiga-like toxin 1 or 2 (or Vero toxins) and the DNA ligand sequences are selected from SEQ ID NO's. 544-612.

13. The DNA ligand sequence of claim 9 wherein the target is a strain of Enterococcus faecalis or a closely related Gram positive organism and the DNA ligand sequences are selected from SEQ ID NO's. 59-66.

14. The DNA ligand sequence of claim 9 wherein the target is Cryptosporidium parvum (or a closely related species) and the DNA ligand sequences are selected from SEQ ID NO's. 613-636.

15. The DNA ligand sequence of claim 9 wherein the target is a species of Giardia parasite and the DNA ligand sequences are selected from SEQ ID NO's. 637-650.

16. The DNA ligand sequence of claim 9 wherein the target is a general Gram negative bacterial pathogen as detected by its lipopolysaccharide (LPS endotoxin) or common core component of LPS and the DNA ligand sequences are selected from SEQ ID NO's. 225-278.

17. The DNA ligand sequence of claim 9 wherein the target is a general Gram positive bacterial pathogen or a pathogenic or nonpathogenic mold or fungus as detected by its peptidoglycan or chitin or common components such as N-acetyl-glucosamine (NAG) and N-acetylmuramic acid (NAM) and the DNA ligand sequences are selected from SEQ ID NO's. 381-404.

18. The DNA ligand sequence of claim 1, wherein said nucleic acid sequence is produced by chemical synthesis, wherein said nucleic acid sequence is linear, wherein said nucleic acid sequence has two- or three-dimensional linked multiple aptamers or aptamer binding sites in which said aptamer binding sites have two or more single-stranded segments of 5-10 bases, and wherein intervening nucleotide sequences between said aptamer binding sites do not bind the target.

19. The DNA ligand sequence of claim 1, wherein said nucleic acid sequence is produced biosynthetically (enzymatically) by polymerase chain reaction ("PCR"), asymmetric PCR, or other DNA polymerase-based reaction using a complementary template DNA into which aptamers or their binding sites are linked with intervening nucleotide sequences that do not bind the target.